PMO
type: Ontology
creator: Institute of Medical Information, Chinese Academy of Medical Sciences/Peking Union Medical College
description: PMO is an open, extensible ontology aimed to integrate the terms in field of precision medicine.

Definition
type: AnnotationProperty
Definition: The definition of the resource.

Example
type: AnnotationProperty
Definition: The example of the relationship appearing in biomedical text.

MCID
type: AnnotationProperty
Definition: The ID of the corresponding concept of the resource in PMV（Precision Medicine Vocabulary）.

MRID
type: AnnotationProperty
Definition: The unique identifier of the relationship in PMO.

PMOID
type: AnnotationProperty
Definition: The unique identifier of the class in PMO.

Source of Example
type: AnnotationProperty
Definition: The source of the example, usually PubMed.

Subclass_of
type: AnnotationProperty
Definition: The superclass of the resource.

Synonym
type: AnnotationProperty
Definition: The synonym of the resource in other databases.

Tree Number
type: AnnotationProperty
Definition: The hierarchy of the resource in PMO tree.

database_cross_reference
type: AnnotationProperty
Definition: The ID of the resource in other databases.

is biomarker of
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025066
range: PMO:00025114
Definition: A gene influences or predicts the incidence of outcome or disease.
MRID: R00000001
Subclass_of: owl:topObjectProperty
Tree Number: T1

is biomarker-efficacy of
type: ObjectProperty
sub property of: is biomarker of
domain: PMO:00025066
range: PMO:00025114
Definition: A gene can be used to measure the efficacy of drugs or therapeutic methods in the treatment of a disease.
Example: Human TP53 protein has been used as a biomarker for measuring the efficacy of iloprost in the treatment of lung neoplasm.
MRID: R00000002
Source of Example: Source: GVK Biosciences-NCT00084409
Subclass_of: is biomarker of
Tree Number: T1.1

is biomarker-diagnosis of
type: ObjectProperty
sub property of: is biomarker of
domain: PMO:00025066
range: PMO:00025114
Definition: A gene can be used to diagnose a disease.
Example: Human TP53 gene has been used as a biomarker for diagnosis of chronic lymphocytic leukemia.
MRID: R00000003
Source of Example: Source: GVK Biosciences-NCT00923507
Subclass_of: is biomarker of
Tree Number: T1.2

is biomarker-prognosis of
type: ObjectProperty
sub property of: is biomarker of
domain: PMO:00025066
range: PMO:00025114
Definition: A gene can be used to predict the probable course or outcome of a disease.
Example: Human TP53 protein has been used as a biomarker for prognosis of breast cancer.
MRID: R00000004
Source of Example: Source: GVK Biosciences-NCT00646555
Subclass_of: is biomarker of
Tree Number: T1.3

is biomarker-response to therapy of
type: ObjectProperty
sub property of: is biomarker of
domain: PMO:00025066
range: PMO:00025114
Definition: A gene can be used for measuring the response of a disease to particular therapies.
Example: Human TP53 gene has been used as a biomarker for response to therapy belinostat/MK 1775 in the treatment of acute myeloid leukemia.
MRID: R00000005
Source of Example: Source: GVK Biosciences-NCT02381548
Subclass_of: is biomarker of
Tree Number: T1.4

is biomarker-unspecified application of
type: ObjectProperty
sub property of: is biomarker of
domain: PMO:00025066
range: PMO:00025114
Definition: A gene is a potential biomarker of a disease-that is, the gene (when mutated or aberrant expressed) is associated with a disease, but the precise function is unclear.
Example: Upregulation of human P53 [TP53] protein in nuclei from cells malignant tumor of prostate is associated with prostate cancer in human (Biomarker status: potential biomarker).
MRID: R00000006
Source of Example: PMID: 17145880
Subclass_of: is biomarker of
Tree Number: T1.5

is biomarker-disease progression of
type: ObjectProperty
sub property of: is biomarker of
domain: PMO:00025066
range: PMO:00025114
Definition: A gene is linked to the development of a disease.
Example: Human TP53 protein has been used as a biomarker for progression of endometrial carcinoma.
MRID: R00000007
Source of Example: Source: GVK Biosciences-NCT00598845
Subclass_of: is biomarker of
Tree Number: T1.6

is associated with
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025066
range: PMO:00025114
Definition: A gene (when mutant or aberrant expressed) influences (increases or decreases) the frequency of a disease.
Example: Mutant human TP53 gene (unspecified DNA mutation) is associated with myeloproliferative neoplasm blast phase in human.
MRID: R00000008
Source of Example: PMID:24478400
Subclass_of: owl:topObjectProperty
Tree Number: T2

is not associated with
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025066
range: PMO:00025114
Definition: A gene is not related to a disease.
MRID: R00000009
Subclass_of: owl:topObjectProperty
Tree Number: T3

play functional roles in
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025066
range: PMO:00025114
Definition: A gene (or the protein encoded by the gene) has some effects on, or can influence a disease.
MRID: R00000010
Subclass_of: owl:topObjectProperty
Tree Number: T4

play functional roles-organismal processes in
type: ObjectProperty
sub property of: play functional roles in
domain: PMO:00025066
range: PMO:00025114
Definition: A gene functions in the organisms.
MRID: R00000011
Subclass_of: play functional roles in
Tree Number: T4.1

play functional roles-organismal processes-quantity of in
type: ObjectProperty
sub property of: play functional roles-organismal processes in
domain: PMO:00025066
range: PMO:00025114
Definition: The mutant of a gene can increase the incidence of a disease.
Example: In human, mutant human TP53 gene (substitution c.535C>A [somatic] (rs587780070)) probably increases quantity of carcinoma of gallbladder.
MRID: R00000012
Source of Example: Source: ClinVar-RCV000435925.1
Subclass_of: play functional roles-organismal processes in
Tree Number: T4.1.1

play functional roles-organismal processes-growth of in
type: ObjectProperty
sub property of: play functional roles-organismal processes in
domain: PMO:00025066
range: PMO:00025114
Definition: A gene influences (increases or decreases) the growth of a disease.
Example: Human p53 [TP53] protein decreases growth of Saccharomyces pombe.
MRID: R00000013
Source of Example: PMID:11264458
Subclass_of: play functional roles-organismal processes in
Tree Number: T4.1.2

play functional roles-organismal processes-formation of in
type: ObjectProperty
sub property of: play functional roles-organismal processes in
domain: PMO:00025066
range: PMO:00025114
Definition: The mutant of a gene is associated with occurence of a diease.
Example: Transgenic mutant human p53 [TP53] protein (substitution p.R273H) in mouse lung increases formation to adenocarcinoma in lung from 4 month-old mouse.
MRID: R00000014
Source of Example: PMID:12420220
Subclass_of: play functional roles-organismal processes in
Tree Number: T4.1.3

play functional roles-organismal processes-remission in
type: ObjectProperty
sub property of: play functional roles-organismal processes in
domain: PMO:00025066
range: PMO:00025114
Definition: A gene is related with the remission of a disease.
Example: Mutant human p53 [TP53] protein (unspecified protein mutation) decreases remission in human not expressing human Estrogen Receptor protein(s) and exhibiting breast cancer that is increased by tamoxifen.
MRID: R00000015
Source of Example: PMID:10786679
Subclass_of: play functional roles-organismal processes in
Tree Number: T4.1.4

play functional roles in
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025066
range: Cell Line
Definition: A gene (or the protein encoded by the gene) has some effects on cellular process.
MRID: R00000016
Subclass_of: owl:topObjectProperty
Tree Number: T5

play functional roles-cellular processes in
type: ObjectProperty
sub property of: play functional roles in
domain: PMO:00025066
range: Cell Line
Definition: A gene has activities (binding activities, transcription, expression, etc.) on another gene at the cellular level.
MRID: R00000017
Subclass_of: play functional roles in
Tree Number: T5.1

play functional roles-cellular processes in-expression in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene involves the gene expression regulation in a cell line.
Example: Interference of human p53 [TP53] mRNA by shRNA increases expression of human RGS13 protein in HS Sultan cells
MRID: R00000018
Source of Example: PMID:21531726
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.1

play functional roles-cellular processes in-apoptosis of in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene regulates(increases and decreases)cell apoptosis.
Example: Nicotinamide [niacinamide] increases apoptosis of human CLL B cells in cell culture that is dependent on human P53 [TP53] protein.
MRID: R00000019
Source of Example: PMID:21565980
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.2

play functional roles-cellular processes in-growth of in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene regulates(increases and decreases)cell growth in a cell line.
Example: Human P53 [TP53] protein decreases growth of MCF7 cells in cell culture that is increased by Hbxip [LAMTOR5] protein.
MRID: R00000020
Source of Example: PMID:12082628
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.3

play functional roles-cellular processes in-cell death of in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene regulates (increases and decreases) cell death.
Example: Human p53 [TP53] protein decreases death of human breast cancer cell lines that is increased by down-regulation of human TERT protein.
MRID: R00000021
Source of Example: PMID:19214186
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.4

play functional roles-cellular processes in-proliferation of in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene involves in the cell proliferation, that is, increase or decrease the cell proliferation.
Example: Human P53 [TP53] protein decreases proliferation of Daoy cells in cell culture that is increased by human GLI1 protein.
MRID: R00000022
Source of Example: PMID:26229109
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.5

play functional roles-cellular processes in-cell cycle progression of in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene mediates (decreases or increases) the arrest in cell cycle progression.
Example: In cell culture, human P53 [TP53] protein decreases cell cycle progression of exponentially growing T98G cells.
MRID: R00000023
Source of Example: PMID:2143581
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.6

play functional roles-cellular processes in-survival of in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene mediates (decreases or increases) the survival of celles.
Example: P33ING1 [ING1] protein and human p53 [TP53] protein decrease survival of T.Tn cells.
MRID: R00000024
Source of Example: PMID:11850840
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.7

play functional roles-cellular processes in-morphology of in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene affects the morphology of cells in a cell line.
Example: In 3-D culture, depletion of mutant human p53 [TP53] protein (substitution p.R280K) affects morphology of MDA-231 cells.
MRID: R00000025
Source of Example: PMID:22265415
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.8

play functional roles-cellular processes in-differentiation of in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene regulates (increases and decreases) the rate of differentiation of cells.
Example: Human p53 [TP53] protein increases monocytic differentiation of transformed 32D cells that involves V-SRC [SRC] protein.
MRID: R00000026
Source of Example: PMID:8552075
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.9

play functional roles-cellular processes in-mitosis of in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene influences the mitosis stage of cells.
Example: In Hct 116 cells, null mutant human p53 [TP53] gene (unspecified DNA mutation) decreases the arrest in mitosis stage of Hct 116 cells that is increased by human Survivin [BIRC5] antisense.
MRID: R00000027
Source of Example: PMID:14581472
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.10

play functional roles-cellular processes in-colony formation by in
type: ObjectProperty
sub property of: play functional roles-cellular processes in
domain: PMO:00025066
range: Cell Line
Definition: A gene involves in the colony formation in cell.
Example: Human TP53 protein is involved in colony formation in cell culture by fibroblasts from mutant 13.5 day-old embryonic mouse with a homozygous null knockout of mouse p53 [Trp53] gene.
MRID: R00000028
Source of Example: PMID:23612969
Subclass_of: play functional roles-cellular processes in
Tree Number: T5.1.11

play functional roles in
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025066
range: PMO:00025066
Definition: A gene has some effects on, or can influence another gene.
MRID: R00000029
Subclass_of: owl:topObjectProperty
Tree Number: T6

play functional roles-molecular processes in
type: ObjectProperty
sub property of: play functional roles in
domain: PMO:00025066
range: PMO:00025066
Definition: A gene has activities (binding activities, transcription, expression, etc.) on another gene at the molecular level.
MRID: R00000030
Subclass_of: play functional roles in
Tree Number: T6.1

play functional roles-molecular processes-expression of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025066
range: PMO:00025066
Definition: A gene regulates (increases or decreases) the expression of another gene.
Example: Mutant human p53 [TP53] protein (substitution p.D281G) increases expression of human MDR1 [ABCB1] protein.
MRID: R00000031
Source of Example: PMID:11483599
Subclass_of: play functional roles-molecular processes in
Tree Number: T6.1.1

play functional roles-molecular processes-transcription of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025066
range: PMO:00025066
Definition: A gene regulates (increase or decrease) the transcription of another gene .
Example: In H1299 cells, c-Myc [MYC] protein increases transcription of human SURVIVIN [BIRC5] gene that is decreased by human P53 [TP53] protein.
MRID: R00000032
Source of Example: PMID:12748190
Subclass_of: play functional roles-molecular processes in
Tree Number: T6.1.2

play functional roles-molecular processes-transactivation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025066
range: PMO:00025066
Definition: A gene has an effect on (increase, decrease or mediate) the transactivation of another gene.
Example: Mutant human p53 [TP53] protein (substitution p.R281G) increases transactivation of DNA endogenous promoter from human MDR1 [ABCB1] gene.
MRID: R00000033
Source of Example: PMID:11803461
Subclass_of: play functional roles-molecular processes in
Tree Number: T6.1.3

play functional roles-molecular processes-activation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025066
range: PMO:00025066
Definition: A gene influences (causes, causes little, is necessary for or has no influence on ) the activation of another gene.
Example: Interference of human p53 [TP53] mRNA in NT2/D1 cells by siRNA decreases activation of human ANXA1 gene in NT2/D1 cells that is mediated by cisplatin in culture medium.
MRID: R00000034
Source of Example: PMID:15940259
Subclass_of: play functional roles-molecular processes in
Tree Number: T6.1.4

play functional roles-molecular processes-activity of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025066
range: PMO:00025066
Definition: A gene is related to the activity of another gene.
Example: Human p53 [TP53] protein increases excision repair activity of Ape [APEX1] protein.
MRID: R00000035
Source of Example: PMID:15342409
Subclass_of: play functional roles-molecular processes in
Tree Number: T6.1.5

play functional roles-molecular processes-binding of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025066
range: PMO:00025066
Definition: A gene encodes a protein that can bind to the promoter of another gene.
Example: Human p53 [TP53] protein causes little or no change in binding of promoter fragment from human Apob gene consisting of HNF4 binding site and rat Hnf4a protein.
MRID: R00000036
Source of Example: PMID:11818510
Subclass_of: play functional roles-molecular processes in
Tree Number: T6.1.6

play functional roles-molecular processes-methylation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025066
range: PMO:00025066
Definition: A gene is related to the methylation of another gene.
Example: Loss of human p53 [TP53] protein decreases methylation of human TROP1 [EPCAM] gene.
MRID: R00000037
Source of Example: PMID:12642870
Subclass_of: play functional roles-molecular processes in
Tree Number: T6.1.7

has mutation
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025066
range: PMO:00025101
Definition: A mutation occurs in or near a gene, usually at a given position.
MRID: R00000038
Subclass_of: owl:topObjectProperty
Tree Number: T7

has mutation-somatic
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has a somatic mutation.
Example: Mutant human TP53 gene (substitution c.374C>T translating to p.T125M [somatic missense]) is observed with natural killer cell lymphoma in lymphoid tissue from human paranasal sinus (COSMIC: observed in 4 of 100 samples).
MRID: R00000039
Source of Example: PMID:15643509
Subclass_of: has mutation
Tree Number: T7.1

has mutation-missense
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A missense mutant gene is observed.
Example: Missense mutant human p53 [TP53] protein (substitution p.C176S) in human is associated with B-cell prolymphocytic leukemia in human.
MRID: R00000040
Source of Example: PMID:9058723
Subclass_of: has mutation
Tree Number: T7.2

has mutation-germline
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A germline mutant gene is observed.
Example: Author-stated loss-of-function germline mutant human TP53 gene (unspecified DNA mutation) is associated with primary peritoneal cancer in human
MRID: R00000041
Source of Example: PMID:22006311
Subclass_of: has mutation
Tree Number: T7.3

has mutation-nonsense
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A nonsense mutation is observed in a gene.
Example: Mutant human TP53 gene (substitution c.295C>T translating to p.Q99* [somatic homozygous nonsense]) is observed with serous adenocarcinoma in human ovary (COSMIC: observed in 2 of 332 samples).
MRID: R00000042
Source of Example: PMID:21720365
Subclass_of: has mutation
Tree Number: T7.4

has mutation-null
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has a null mutation, that is ,unspecified DNA mutation.
Example: In cells, null homozygous mutant human p53 [TP53] gene (unspecified DNA mutation) increases apoptosis of cells that is decreased by human ATF3 protein.
MRID: R00000043
Source of Example: PMID:12161427
Subclass_of: has mutation
Tree Number: T7.5

has mutatin-heterozygous
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has a heterozygous mutation.
Example: Mutant human TP53 gene (substitution c.733G>T translating to p.G245C [somatic heterozygous missense]) is observed with adenocarcinoma in human lung (COSMIC: observed in 2 of 185 samples).
MRID: R00000044
Source of Example: PMID:18948947
Subclass_of: has mutation
Tree Number: T7.6

has mutation-C-terminal truncation
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A C-terminal truncation mutation is observed in a gene.
Example: Mutant human p53 [TP53] protein (C-terminal truncation p.X213* or 213-End) is associated with sporadic Burkitt's lymphoma in human.
MRID: R00000045
Source of Example: PMID:2052620
Subclass_of: has mutation
Tree Number: T7.7

has mutation-N-terminal truncation
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A N-terminal truncation mutation is observed in a gene.
Example: Mutant human p53 [TP53] protein (N-terminal truncation 1-63) causes little or no change in apoptosis of cell lines.
MRID: R00000046
Source of Example: PMID:9582339
Subclass_of: has mutation
Tree Number: T7.8

has mutation-frameshift-causing
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has a frameshift-causing mutation.
Example: Frameshift mutant human p53 [TP53] protein (insertion) in human is associated with B-cell prolymphocytic leukemia in human.
MRID: R00000047
Source of Example: PMID:9058723
Subclass_of: has mutation
Tree Number: T7.9

has mutation-silent
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has a silent mutation, that is, the mutation does not alter the phenotype of the organism where it ouucrs.
Example: Mutant human TP53 gene (substitution c.669T>C translating to p.P223P [silent]) is observed with sezary syndrome in lymphoid tissue from human skin (COSMIC: observed in 2 of 11 samples).
MRID: R00000048
Source of Example: PMID:17107393
Subclass_of: has mutation
Tree Number: T7.10

has mutation-DNA deletion
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has a DNA sequence deletion.
Example: Mutant human P53 [TP53] gene (gene deletion) is associated with ALK-negative anaplastic large cell lymphoma in human.
MRID: R00000049
Source of Example: PMID:24004669
Subclass_of: has mutation
Tree Number: T7.11

has mutation-in frame
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has an in frame mutation.
Example: Mutant human TP53 gene (indel c.534_535delCCinsTT translating to p.H179Y [somatic in frame missense]) is observed with basal-cell carcinoma in human skin (COSMIC: observed in 2 of 32 samples).
MRID: R00000050
Source of Example: PMID:11981662
Subclass_of: has mutation
Tree Number: T7.12

has mutation-splice-site mutation
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has a mutation in its DNA bindin domain.
Example: Splice-site mutant human P53 [TP53] gene (substitution g.?G>A) is associated with breast cancer in human.
MRID: R00000051
Source of Example: PMID:8577720
Subclass_of: has mutation
Tree Number: T7.13

has mutation-DNA insertion
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has a DNA sequence insertion.
Example: Mutant human p53 [TP53] gene (insertion) is associated with hairy-cell leukemia in human.
MRID: R00000052
Source of Example: PMID:2052620
Subclass_of: has mutation
Tree Number: T7.14

has mutation-DNA SNP substitution mutation
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has a SNP mutation.
Example: Mutant human TP53 gene (SNP substitution (rs1042522)) causes little or no change in the risk of recurrent breast cancer in human exhibiting invasive breast cancer that involves cyclophosphamide/5-fluorouracil/methotrexate (used here to treat invasive breast cancer).
MRID: R00000053
Source of Example: PMID:17558308
Subclass_of: has mutation
Tree Number: T7.15

has mutation-loss of heterozygosity
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has loss of heterozygosity mutant, that is, with the whole gene deletion.
Example: In human breast carcinoma, loss of heterozygosity mutant human P53 [TP53] gene (whole gene deletion) increases expression of human SURVIVIN delta EX3 [product of BIRC5] mRNA in human breast carcinoma.
MRID: R00000054
Source of Example: PMID:16847456
Subclass_of: has mutation
Tree Number: T7.16

has mutation-loss of heterozygosity
type: ObjectProperty
sub property of: has mutation
domain: PMO:00025066
range: PMO:00025101
Definition: A gene has an intertion or deletion of bases.
Example: Mutant human TP53 gene (indel c.214_215delCCinsTG (rs730882014)) is observed with Li-Fraumeni syndrome 1 in human.
MRID: R00000055
Source of Example: Source: ClinVar-RCV000410841.1
Subclass_of: has mutation
Tree Number: T7.17

play functional roles in
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025081
range: PMO:00025066
Definition: There're functional relationships between a protein and a gene.
MRID: R00000056
Subclass_of: owl:topObjectProperty
Tree Number: T8

play functional roles-molecular processes in
type: ObjectProperty
sub property of: play functional roles in
domain: PMO:00025081
range: PMO:00025066
Definition: A protein is related to a gene at the molecular level.
MRID: R00000057
Subclass_of: play functional roles in
Tree Number: T8.1

play functional roles-molecular processes-phosphorylation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025066
range: PMO:00025081
Definition: A gene regulates (increases or decreases) the phosphorylation of a protein.
Example: Human p53 [TP53] protein decreases inhibitory phosphorylation of human CDC2 [CDK1] protein to phosphorylated (T14;Y15) human CDC2 [CDK1] protein that is increased by gamma radiation.
MRID: R00000058
Source of Example: PMID:9715268
Subclass_of: play functional roles-molecular processes in
Tree Number: T8.1.1

play functional roles-molecular processes-binding of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025066
Definition: A protein modulates the expression of another gene by regulating the binding of another protein to this gene, or a protein can bind to the promoter of another gene.
Example: Heterozygous mutant human P53 [TP53] gene (unspecified DNA mutation) increases binding of human AHA1 [AHSA1] protein and human Hsp90 protein(s) in cultured epithelial cells from human exhibiting Li-Fraumeni syndrome.
MRID: R00000059
Source of Example: PMID:24451373
Subclass_of: play functional roles-molecular processes in
Tree Number: T8.1.2

play functional roles-molecular processes-repression of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025066
range: PMO:00025081
Definition: A protein regulates (increases or decreases) the repression of a gene(potential target).
Example: In Pc 3 cells, human P53 [TP53] protein increases repression of human STK6 [AURKA] gene.
MRID: R00000060
Source of Example: PMID:16798743
Subclass_of: play functional roles-molecular processes in
Tree Number: T8.1.3

play functional roles-molecular processes-indction of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025066
Definition: A protein is necessary for the induction of a gene.
Example: In H1299 cells, human p53 [TP53] protein increases induction of human Acta2 mRNA.
MRID: R00000061
Source of Example: PMID:12213815
Subclass_of: play functional roles-molecular processes in
Tree Number: T8.1.4

play functional roles-molecular processes-downregulation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025066
Definition: A protein represses a gene, for instance, by binding to the gene promoter which can be transactivating element.
Example: Human P53 [TP53] protein is necessary for downregulation of human BCL2 protein in Hct 116 cells that is increased by LL37 [product of CAMP] protein.
MRID: R00000062
Source of Example: PMID:23100468
Subclass_of: play functional roles-molecular processes in
Tree Number: T8.1.5

play functional roles-molecular processes-splicing of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025066
Definition: A protein regulates the splicing of a gene, that is, increases or decreases the splicing of the gene.
Example: Human P53 [TP53] protein increases splicing of human NOXA [PMAIP1] mRNA to human Noxa [product of PMAIP1] mRNA in H1299 cells.
MRID: R00000063
Source of Example: PMID:18630524
Subclass_of: play functional roles-molecular processes in
Tree Number: T8.1.6

play functional roles-molecular processes-transrepression of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025066
Definition: A protein induces transcriptional repression of a gene.
Example: Poly(ADP-ribosyl)ation of human P53 [TP53] protein is necessary for transrepression of human MTA1 gene in HepG2 cells that is mediated by human P53 [TP53] protein.
MRID: R00000064
Source of Example: PMID:22286760
Subclass_of: play functional roles-molecular processes in
Tree Number: T8.1.7

play functional roles in
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025081
range: PMO:00025081
Definition: There're functional relationships between to proteins.
MRID: R00000065
Subclass_of: owl:topObjectProperty
Tree Number: T9

play functional roles-molecular processes in
type: ObjectProperty
sub property of: play functional roles in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein is related to another protein at the molecular level.
MRID: R00000066
Subclass_of: play functional roles in
Tree Number: T9.1

play functional roles-molecular processes-activity of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein regulates (increases or decreases) the activity of another protein.
Example: Human p53 [TP53] protein increases excision repair activity of Ape [APEX1] protein.
MRID: R00000067
Source of Example: PMID:15342409
Subclass_of: play functional roles-molecular processes in
Tree Number: T9.1.1

play functional roles-molecular processes-degradation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein involves in (increases or decreases) the degradation of another protein.
Example: In vascular smooth muscle cells from human blood vessels, human p53 [TP53] protein is involved in degradation of human CYCLIN D1 [CCND1] protein that is decreased by restenosis of blood vessels from human.
MRID: R00000068
Source of Example: PMID:11884368
Subclass_of: play functional roles-molecular processes in
Tree Number: T9.1.2

play functional roles-molecular processes-downregulation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein is necessary for the downregulation of another protein.
Example: Human P53 [TP53] protein is necessary for downregulation of human BCL2 protein in Hct 116 cells that is increased by LL37 [product of CAMP] protein.
MRID: R00000069
Source of Example: PMID:23100468
Subclass_of: play functional roles-molecular processes in
Tree Number: T9.1.3

play functional roles-molecular processes-ubiquitination of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein regulates (increases or decreases) the ubiquitination of another protein.
Example: Interaction of human CA11 protein and human TP53 protein increases ubiquitination of human CA11 protein.
MRID: R00000070
Source of Example: PMID:17121812
Subclass_of: play functional roles-molecular processes in
Tree Number: T9.1.4

play functional roles-molecular processes-recruitment of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein ifluences the recruitment of another protein.
Example: Human p53 [TP53] protein increases recruitment of human RBBP5 protein to p53 response element from human SHP [NR0B2] gene in HepG2 cells.
MRID: R00000071
Source of Example: PMID:22034226
Subclass_of: play functional roles-molecular processes in
Tree Number: T9.1.5

play functional roles-molecular processes-upregulation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein is necessary for the upregulation of another protein.
Example: Human P53 [TP53] protein is necessary for upregulation of human Bak [BAK1] protein in Hct 116 cells that is increased by LL37 [product of CAMP] protein.
MRID: R00000072
Source of Example: PMID:23100468
Subclass_of: play functional roles-molecular processes in
Tree Number: T9.1.6

play functional roles-molecular processes-acetylation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein involves in (increases or decreases) the acetylation of another protein.
Example: Interaction of human EP300 protein and human TP53 protein increases acetylation of human TP53 protein.
MRID: R00000073
Source of Example: PMID:9744860
Subclass_of: play functional roles-molecular processes in
Tree Number: T9.1.7

play functional roles-molecular processes-inhibition of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein inhibites the activity of another protein.
Example: Interaction of human MDM2 protein and human TP53 protein increases inhibition of active human MDM2 protein.
MRID: R00000074
Source of Example: PMID:12068014
Subclass_of: play functional roles-molecular processes in
Tree Number: T9.1.8

play functional roles-molecular processes-phosphorylation of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025081
Definition: A protein involves in (increases, decreases, is necessay for) the phosphorylation of another protein.
Example: Human P53 [TP53] protein decreases phosphorylation of human 4E-BP1 [EIF4EBP1] protein in Ht 1080 cells.
MRID: R00000075
Source of Example: PMID:20457898
Subclass_of: play functional roles-molecular processes in
Tree Number: T9.1.9

play functional roles in
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025081
range: PMO:00025085
Definition: There're functional relationships between a protein and a miRNA.
MRID: R00000076
Subclass_of: owl:topObjectProperty
Tree Number: T10

play functional roles-molecular processes in
type: ObjectProperty
sub property of: play functional roles in
domain: PMO:00025081
range: PMO:00025085
Definition: A protein is related to a miRNA at the molecular level.
MRID: R00000077
Subclass_of: play functional roles in
Tree Number: T10.1

play functional roles-molecular processes-repression of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025085
Definition: A protein represses a miRNA.
Example: Human p53 [TP53] protein increases repression of human MIR32 mature microRNA in U87 cells.
MRID: R00000078
Source of Example: PMID:22431589
Subclass_of: play functional roles-molecular processes in
Tree Number: T10.1.1

play functional roles-molecular processes-expression of in
type: ObjectProperty
sub property of: play functional roles-molecular processes in
domain: PMO:00025081
range: PMO:00025085
Definition: A protein regulates (increases or decreases) the expression of a miRNA.
Example: Human p53 [TP53] protein increases expression of human hsa-miR-190 [product of MIR190A] mature microRNA in H1299 cells.
MRID: R00000079
Source of Example: PMID:17554199
Subclass_of: play functional roles-molecular processes in
Tree Number: T10.1.2

regulation
type: ObjectProperty
sub property of: topObjectProperty
domain: Chemical and Drug
range: PMO:00025081
Definition: A chemical or a drug regulates the function of a protein.
MRID: R00000080
Subclass_of: owl:topObjectProperty
Tree Number: T11

binding regulation
type: ObjectProperty
sub property of: regulation
domain: Chemical and Drug
range: PMO:00025081
Definition: A drug influences (increases or decreases) the binding of a protein.
Example: Sodium orthovanadate decreases binding of human BCL2 protein and human P53 [TP53] protein in mitochondria from Molt 4 cells that is increased by apoptosis of Molt 4 cells.
MRID: R00000081
Source of Example: PMID:20048077
Subclass_of: regulation
Tree Number: T11.1

activation regulation
type: ObjectProperty
sub property of: regulation
domain: Chemical and Drug
range: PMO:00025081
Definition: A drug influences (increases or decreases) the activation of a protein.
Example: Stigmatellin increases activation of human P53 [TP53] protein in RKO cells.
MRID: R00000082
Source of Example: PMID:20566882
Subclass_of: regulation
Tree Number: T11.2

degradation regulation
type: ObjectProperty
sub property of: regulation
domain: Chemical and Drug
range: PMO:00025081
Definition: A chemical regulates (increases or decreases) the degradation of a protein.
Example: Geldanamycin increases degradation of human p53 [TP53] protein.
MRID: R00000083
Source of Example: PMID:11867746
Subclass_of: regulation
Tree Number: T11.3

stabilization regulation
type: ObjectProperty
sub property of: regulation
domain: Chemical and Drug
range: PMO:00025081
Definition: A chemical regulates (increases or decreases) the stabilization of a protein.
Example: Sulforaphane [sulforafan] increases stabilization of human p53 [TP53] protein in primary keratinocytes from human epidermis foreskin.
MRID: R00000084
Source of Example: PMID:22427654
Subclass_of: regulation
Tree Number: T11.4

ubiquitination regulation
type: ObjectProperty
sub property of: regulation
domain: Chemical and Drug
range: PMO:00025081
Definition: A chemical regulates (increases or decreases) the ubiquitination of a protein.
Example: Dicoumarol [dicumarol] in cell culture causes little or no change in ubiquitination of human p53 [TP53] protein in 293 cells.
MRID: R00000085
Source of Example: PMID:12232053
Subclass_of: regulation
Tree Number: T11.5

acetylation regulation
type: ObjectProperty
sub property of: regulation
domain: Chemical and Drug
range: PMO:00025081
Definition: A chemical regulates (increases or decreases) the acetylatio of a protein.
Example: In A549 cells, depsipeptide [romidepsin] increases acetylation of human P53 [TP53] protein.
MRID: R00000086
Source of Example: PMID:16537920
Subclass_of: regulation
Tree Number: T11.6

localization regulation
type: ObjectProperty
sub property of: regulation
domain: Chemical and Drug
range: PMO:00025081
Definition: A chemical influences(increases or decreases)the nuclear localization of a protein.
Example: Cisplatin increases localization of human p53 [TP53] protein to nuclei.
MRID: R00000087
Source of Example: PMID:11175336
Subclass_of: regulation
Tree Number: T11.7

translocation regulation
type: ObjectProperty
sub property of: regulation
domain: Chemical and Drug
range: PMO:00025081
Definition: A chemical influences(cause no/little effect, increases or decreases)the nuclear localization of a protein.
Example: Camptothecin increases translocation of human p53 [TP53] protein to mitochondria from Hct 116 cells.
MRID: R00000088
Source of Example: PMID:16148012
Subclass_of: regulation
Tree Number: T11.8

mutation regulation
type: ObjectProperty
sub property of: topObjectProperty
domain: Chemical and Drug
range: PMO:00025066
Definition: A chemical influences (increases or decreases) the frequency of mutation of a gene.
Example: Aristolochic acid [aristolochic acid I] increases mutation of human p53 [TP53] protein to mutant human p53 [TP53] protein (substitution p.R158G with its DNA binding domain mutated).
MRID: R00000089
Source of Example: PMID:14976251
Subclass_of: owl:topObjectProperty
Tree Number: T12

target of
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025066
range: PMO:00025085
Definition: A gene is a target of a miRNA.
Example: Targeting of human p53 [TP53] mRNA in HEK 293 T cells by MIR25 mature microRNA occurs.
MRID: R00000090
Source of Example: PMID:20935678
Subclass_of: owl:topObjectProperty
Tree Number: T13

is associated with
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025081
range: PMO:00025114
Definition: A protein is related to a disease - that is, a protein (the aberrant expression, including upregulation or downregulation) is linked to, or cause a disease.
Example: Missense mutant human p53 [TP53] protein (substitution p.C176S) in human is associated with B-cell prolymphocytic leukemia in human
MRID: R00000091
Source of Example: PMID:9058723
Subclass_of: owl:topObjectProperty
Tree Number: T14

is associated with
type: ObjectProperty
sub property of: topObjectProperty
domain: PMO:00025101
range: PMO:00025114
Definition: A mutation is linked to the development of disease.
Example: Mutant human p53 [TP53] gene (deletion 393-395) is associated with large-cell follicular lymphoma in human and small cleaved-cell follicular lymphoma in human.
MRID: R00000092
Source of Example: PMID:9354678
Subclass_of: owl:topObjectProperty
Tree Number: T15

impact of
type: ObjectProperty
sub property of: topObjectProperty
domain: Chemical and Drug
range: PMO:00025066
Definition: A drug influences (increases or decreases) the expression of a gene.
Example: In human granulosa cells, forskolin is involved in expression of human TP53 mRNA.
MRID: R00000093
Source of Example: PMID:15026540
Subclass_of: owl:topObjectProperty
Tree Number: T16

Anatomical Structure
type: Class
subclass of: Thing
MCID: MC00231834
PMOID: PMO:00000001
Subclass_of: owl:Thing
Synonym: Anatomic structures
Synonym: Anatomical structure
Synonym: Anatomical structure (body structure)
Synonym: Anatomy
Synonym: Biological structure
Synonym: anatomic structure
Synonym: anatomical structure
Synonym: anatomical structures
Synonym: anatomy
Synonym: biological structure
Tree Number: T1
database_cross_reference: AOD:0000001708
database_cross_reference: AOD:0000017024
database_cross_reference: CHV:0000042886
database_cross_reference: CHV:0000044715
database_cross_reference: CSP:4000-0131
database_cross_reference: FMA:305751
database_cross_reference: FMA:67135
database_cross_reference: MEDLINEPLUS:138
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:T-D0005
database_cross_reference: SNOMEDCT_US:91723000
database_cross_reference: UWDA:67135

Embryonic Structures
type: Class
subclass of: Anatomical Structure
MCID: MC00004377
PMOID: PMO:00000002
Subclass_of: Anatomical Structure
Synonym: EMBRYONIC STRUCTURES
Synonym: Embryologic Structure
Synonym: Embryological structure
Synonym: Embryonic Structure
Synonym: Embryonic structure
Synonym: Embryonic structure (body structure)
Synonym: Embryonic structure, NOS
Synonym: F6-F7 EMBRYONIC STRUCTURES
Synonym: Structure, Embryonic
Synonym: Structures, Embryonic
Tree Number: T1.1
database_cross_reference: FMA:69067
database_cross_reference: MSH:D004628
database_cross_reference: NCI:C13229
database_cross_reference: RCD:Xa1Ia
database_cross_reference: SNMI:T-F6000
database_cross_reference: SNOMEDCT_US:667009

Gubernaculum
type: Class
subclass of: Embryonic Structures
MCID: MC01054834
PMOID: PMO:00000003
Subclass_of: Embryonic Structures
Synonym: Gubernacula
Tree Number: T1.1.1
database_cross_reference: MSH:D000071477

Blastomeres
type: Class
subclass of: Embryonic Structures
subclass of: Embryonic Stem Cells
MCID: MC00001795
PMOID: PMO:00000004
Subclass_of: Embryonic Stem Cells
Subclass_of: Embryonic Structures
Synonym: Blastomere
Synonym: Embryo stage 2
Synonym: Structure of blastomere
Synonym: Structure of blastomere (body structure)
Synonym: Structure of embryo stage 2
Synonym: Structure of embryo stage 2 (body structure)
Synonym: blastomere
Synonym: blastomeres
Tree Number: T1.1.2
Tree Number: T2.34.7.1.4
database_cross_reference: CHV:0000001962
database_cross_reference: CHV:0000057128
database_cross_reference: FMA:72551
database_cross_reference: MSH:D001757
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12518
database_cross_reference: SNOMEDCT_US:14938003
database_cross_reference: SNOMEDCT_US:296383004
database_cross_reference: SNOMEDCT_US:367618007
database_cross_reference: UWDA:72551

Branchial Region
type: Class
subclass of: Embryonic Structures
MCID: MC00001924
PMOID: PMO:00000005
Subclass_of: Embryonic Structures
Synonym: Branchial Regions
Synonym: Region, Branchial
Synonym: Regions, Branchial
Tree Number: T1.1.3
database_cross_reference: MSH:D001934

Cleavage Stage, Ovum
type: Class
subclass of: Embryonic Structures
MCID: MC00002946
PMOID: PMO:00000006
Subclass_of: Embryonic Structures
Synonym: Cleavage Stages, Ovum
Synonym: Embryo stage 1
Synonym: Embryo stage 1 structure
Synonym: Embryo stage 1 structure (body structure)
Synonym: Ovum Cleavage Stage
Synonym: Ovum Cleavage Stages
Synonym: Ovum Segmentation Stage
Synonym: Ovum Segmentation Stages
Synonym: Segmentation Stage, Ovum
Synonym: Segmentation Stages, Ovum
Tree Number: T1.1.4
database_cross_reference: CSP:1016-6956
database_cross_reference: MSH:D002970
database_cross_reference: SNMI:T-F5101
database_cross_reference: SNOMEDCT_US:9156001

Cloaca
type: Class
subclass of: Embryonic Structures
MCID: MC00002956
PMOID: PMO:00000007
Subclass_of: Embryonic Structures
Synonym: CLOACA
Synonym: Cloaca Chamber
Synonym: Cloaca NOS
Synonym: Cloaca structure
Synonym: Cloaca structure (body structure)
Synonym: Cloacas
Synonym: cloaca
Tree Number: T1.1.5
database_cross_reference: CHV:0000003048
database_cross_reference: ICD10CM:Q43.7
database_cross_reference: MSH:D002988
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34127
database_cross_reference: NCI_CDISC:C34127
database_cross_reference: SNM:T-89430
database_cross_reference: SNMI:T-F6630
database_cross_reference: SNOMEDCT_US:64582000

Embryo, Mammalian
type: Class
subclass of: Embryonic Structures
MCID: MC00629046
PMOID: PMO:00000008
Subclass_of: Embryonic Structures
Synonym: Embryos, Mammalian
Synonym: Mammalian Embryo
Synonym: Mammalian Embryos
Tree Number: T1.1.6
database_cross_reference: MSH:D004622

Blastocyst
type: Class
subclass of: Embryo, Mammalian
MCID: MC00432618
PMOID: PMO:00000009
Subclass_of: Embryo, Mammalian
Synonym: Blastocyst structure
Synonym: Blastocyst structure (body structure)
Synonym: Blastocysts
Synonym: Blastosphere
Synonym: Blastula
Synonym: Embryo, Preimplantation
Synonym: Embryos, Preimplantation
Synonym: Preimplantation Embryo
Synonym: Preimplantation Embryos
Synonym: blastocyst
Tree Number: T1.1.6.1
database_cross_reference: AOD:0000002019
database_cross_reference: AOD:0000021711
database_cross_reference: AOD:0000021712
database_cross_reference: CHV:0000001960
database_cross_reference: CHV:0000057130
database_cross_reference: CSP:1016-6956
database_cross_reference: FMA:83041
database_cross_reference: LCH:U000602
database_cross_reference: LCH_NW:sh85014801
database_cross_reference: MSH:D001755
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13739
database_cross_reference: SNOMEDCT_US:308765000

Trophoblasts
type: Class
subclass of: Blastocyst
subclass of: Placenta
subclass of: Endocrine Cells
MCID: MC00013150
PMOID: PMO:00000010
Subclass_of: Blastocyst
Subclass_of: Endocrine Cells
Subclass_of: Placenta
Synonym: Trophoblast
Synonym: Trophoblast structure
Synonym: Trophoblast structure (body structure)
Synonym: Trophoblast, NOS
Synonym: trophoblast
Synonym: trophoblasts
Tree Number: T1.1.17.3
Tree Number: T1.1.6.1.1
Tree Number: T2.11.6
database_cross_reference: CHV:0000012594
database_cross_reference: CSP:2404-5986
database_cross_reference: FMA:83029
database_cross_reference: LCH:U004791
database_cross_reference: LCH_NW:sh85138048
database_cross_reference: LNC:LP65556-0
database_cross_reference: LNC:MTHU026848
database_cross_reference: MSH:D014327
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C93292
database_cross_reference: NCI_NCI-GLOSS:CDR0000446120
database_cross_reference: SNM:T-88110
database_cross_reference: SNMI:T-F1110
database_cross_reference: SNOMEDCT_US:25149004

Blastocyst Inner Cell Mass
type: Class
subclass of: Blastocyst
MCID: MC00583200
PMOID: PMO:00000011
Subclass_of: Blastocyst
Synonym: Inner Cell Mass of Blastocyst
Synonym: Inner Cell Mass, Blastocyst
Tree Number: T1.1.6.1.2
database_cross_reference: MSH:D053624

Extraembryonic Membranes
type: Class
subclass of: Embryo, Mammalian
subclass of: Membranes
MCID: MC00433269
PMOID: PMO:00000012
Subclass_of: Embryo, Mammalian
Subclass_of: Membranes
Synonym: Extra Embryonic Membranes
Synonym: Extra-Embryonic Membrane
Synonym: Extra-Embryonic Membranes
Synonym: Extra-embryonic membrane
Synonym: Extraembryonic Membrane
Synonym: Extraembryonic membranes
Synonym: Extraembryonic membranes (body structure)
Synonym: Extraembryonic membranes structure
Synonym: Extraembryonic membranes structure (body structure)
Synonym: Foetal membranes
Tree Number: T1.1.6.2
Tree Number: T1.3.8.2
database_cross_reference: FMA:305915
database_cross_reference: MSH:D005321
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:326483006
database_cross_reference: SNOMEDCT_US:54134001

Allantois
type: Class
subclass of: Extraembryonic Membranes
MCID: MC00000573
PMOID: PMO:00000013
Subclass_of: Extraembryonic Membranes
Synonym: Allantoic Membrane
Synonym: Membrane, Allantoic
Synonym: Structure of allantois
Synonym: Structure of allantois (body structure)
Tree Number: T1.1.6.2.1
Tree Number: T1.3.8.2.1
database_cross_reference: MSH:D000482
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34101
database_cross_reference: SNM:T-88840
database_cross_reference: SNMI:T-F1840
database_cross_reference: SNOMEDCT_US:83575002

Amnion
type: Class
subclass of: Extraembryonic Membranes
MCID: MC00000800
PMOID: PMO:00000014
Subclass_of: Extraembryonic Membranes
Synonym: Amnions
Synonym: Amniotic
Synonym: Amniotic Membrane
Synonym: Amniotic Membranes
Synonym: Amniotic sac
Synonym: Membrane, Amniotic
Synonym: Membranes, Amniotic
Synonym: Structure of amnion
Synonym: Structure of amnion (body structure)
Synonym: amnion
Tree Number: T1.1.6.2.2
Tree Number: T1.3.8.2.2
database_cross_reference: AOD:0000017038
database_cross_reference: CHV:0000001037
database_cross_reference: CSP:2404-5654
database_cross_reference: FMA:80223
database_cross_reference: LCH:U000208
database_cross_reference: LCH_NW:sh85004562
database_cross_reference: MSH:D000650
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12365
database_cross_reference: SNM:T-88300
database_cross_reference: SNMI:T-F1300
database_cross_reference: SNOMEDCT_US:70847004

Chorion
type: Class
subclass of: Extraembryonic Membranes
MCID: MC00002783
PMOID: PMO:00000015
Subclass_of: Extraembryonic Membranes
Synonym: Chorion, NOS
Synonym: Chorionic
Synonym: Chorionic structure
Synonym: Chorionic structure (body structure)
Synonym: Chorions
Synonym: chorion
Synonym: chorions
Tree Number: T1.1.6.2.3
Tree Number: T1.3.8.2.3
database_cross_reference: CHV:0000002911
database_cross_reference: CSP:2404-5873
database_cross_reference: FMA:80224
database_cross_reference: LCH:U001000
database_cross_reference: LCH_NW:sh85024748
database_cross_reference: MSH:D002823
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34122
database_cross_reference: SNM:T-88210
database_cross_reference: SNMI:T-F1210
database_cross_reference: SNOMEDCT_US:74439004

Chorionic Villi
type: Class
subclass of: Placenta
MCID: MC00002784
PMOID: PMO:00000016
Subclass_of: Placenta
Synonym: Chorionic Villus
Synonym: Chorionic villi
Synonym: Chorionic villi structure
Synonym: Chorionic villi structure (body structure)
Synonym: Chorionic villi, NOS
Synonym: Chorionic villus
Synonym: Placental Villi
Synonym: Placental Villus
Synonym: Villi, Chorionic
Synonym: Villi, Placental
Tree Number: T1.1.17.1
database_cross_reference: CHV:0000002912
database_cross_reference: LCH:U001001
database_cross_reference: LCH_NW:sh85024752
database_cross_reference: LNC:LP208150-5
database_cross_reference: MSH:D002824
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34125
database_cross_reference: SNM:T-88220
database_cross_reference: SNMI:T-F1220
database_cross_reference: SNOMEDCT_US:2049008

Yolk Sac
type: Class
subclass of: Extraembryonic Membranes
subclass of: Embryo, Nonmammalian
MCID: MC00013788
PMOID: PMO:00000017
Subclass_of: Embryo, Nonmammalian
Subclass_of: Extraembryonic Membranes
Synonym: Embryo Vitelline Sac
Synonym: Embryo Vitelline Sacs
Synonym: SAC, YOLK
Synonym: Sac, Yolk
Synonym: Sacs, Yolk
Synonym: Umbilical vesicle
Synonym: Vitelline Sac of Embryo
Synonym: Yolk Sacs
Synonym: Yolk sac
Synonym: Yolk sac structure
Tree Number: T1.1.6.2.4
Tree Number: T1.1.7.3
Tree Number: T1.3.8.2.4
database_cross_reference: CHV:0000013264
database_cross_reference: CSP:5004-0085
database_cross_reference: FMA:87180
database_cross_reference: LCH:U005078
database_cross_reference: LCH_NW:sh85149208
database_cross_reference: LNC:LP7737-2
database_cross_reference: LNC:MTHU002919
database_cross_reference: MSH:D015017
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C14128
database_cross_reference: NCI_CDISC:C14128
database_cross_reference: SNM:T-88400
database_cross_reference: SNMI:T-F1400
database_cross_reference: SNOMEDCT_US:26190007

Embryo, Nonmammalian
type: Class
subclass of: Embryonic Structures
MCID: MC00004374
PMOID: PMO:00000018
Subclass_of: Embryonic Structures
Synonym: Embryo, Non Mammalian
Synonym: Embryo, Non-Mammalian
Synonym: Embryos, Non-Mammalian
Synonym: Embryos, Nonmammalian
Synonym: Non-Mammalian Embryo
Synonym: Non-Mammalian Embryos
Synonym: Nonmammalian Embryo
Synonym: Nonmammalian Embryos
Tree Number: T1.1.7
database_cross_reference: MSH:D004625

Blastoderm
type: Class
subclass of: Embryo, Nonmammalian
MCID: MC00001794
PMOID: PMO:00000019
Subclass_of: Embryo, Nonmammalian
Synonym: Blastoderms
Tree Number: T1.1.7.1
database_cross_reference: LCH:U000603
database_cross_reference: LCH_NW:sh85014802
database_cross_reference: MSH:D001756

Chick Embryo
type: Class
subclass of: Embryo, Nonmammalian
MCID: MC00002613
PMOID: PMO:00000020
Subclass_of: Embryo, Nonmammalian
Synonym: Chick Embryos
Synonym: Chick embryo
Synonym: Embryo, Chick
Synonym: Embryos, Chick
Synonym: chick embryo
Synonym: chick embryos
Tree Number: T1.1.7.2
database_cross_reference: AOD:0000016551
database_cross_reference: CHV:0000002760
database_cross_reference: CSP:0182-1050
database_cross_reference: LCH:U000944
database_cross_reference: MSH:D002642

Blastula
type: Class
subclass of: Embryo, Nonmammalian
MCID: MC00377804
PMOID: PMO:00000021
Subclass_of: Embryo, Nonmammalian
Synonym: Blastulae
Synonym: Non - mammalian blastula
Tree Number: T1.1.7.4
database_cross_reference: LCH_NW:sh94004613
database_cross_reference: MSH:D036703
database_cross_reference: MTH:NOCODE

Chorioallantoic Membrane
type: Class
subclass of: Extraembryonic Membranes
subclass of: Embryo, Nonmammalian
MCID: MC00066665
PMOID: PMO:00000022
Subclass_of: Embryo, Nonmammalian
Subclass_of: Extraembryonic Membranes
Synonym: CAM
Synonym: Chorioallantoic Membranes
Synonym: Membrane, Chorioallantoic
Synonym: Membranes, Chorioallantoic
Synonym: chorioallantoic membrane
Tree Number: T1.1.7.5
Tree Number: T1.3.8.2.5
database_cross_reference: CHV:0000018317
database_cross_reference: CSP:2404-5873
database_cross_reference: MSH:D049033
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C28216
database_cross_reference: NCI_NCI-GLOSS:CDR0000044193

Blastodisc
type: Class
subclass of: Embryo, Nonmammalian
MCID: MC00628696
PMOID: PMO:00000023
Subclass_of: Embryo, Nonmammalian
Synonym: Area, Germinal
Synonym: Areas, Germinal
Synonym: Blastodiscs
Synonym: Disc, Germinal
Synonym: Discs, Germinal
Synonym: Germinal Area
Synonym: Germinal Areas
Synonym: Germinal Disc
Synonym: Germinal Discs
Synonym: Structure of blastodisc
Tree Number: T1.1.7.6
database_cross_reference: MSH:D054239
database_cross_reference: SNOMEDCT_VET:41961000009100

Fetus
type: Class
subclass of: Embryonic Structures
MCID: MC00005086
PMOID: PMO:00000024
Subclass_of: Embryonic Structures
Synonym: FETUS
Synonym: Fetal
Synonym: Fetus (person)
Synonym: Fetuses
Synonym: ^Fetus
Synonym: fetus
Synonym: fetuses
Tree Number: T1.1.8
database_cross_reference: AOD:0000014678
database_cross_reference: CHV:0000005009
database_cross_reference: FMA:63919
database_cross_reference: LCH:U001775
database_cross_reference: LCH_NW:sh85047965
database_cross_reference: LNC:LP104995-8
database_cross_reference: LNC:LP207308-0
database_cross_reference: LNC:LP36106-0
database_cross_reference: LNC:LP6982-5
database_cross_reference: LNC:MTHU002972
database_cross_reference: MSH:D005333
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13235
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13235
database_cross_reference: NCI_NCI-GLOSS:CDR0000046400
database_cross_reference: NCI_NICHD:C13235
database_cross_reference: PSY:19650
database_cross_reference: RCD:7N612
database_cross_reference: SNM:T-89000
database_cross_reference: SNOMEDCT_US:393497002
database_cross_reference: SNOMEDCT_US:394447009

Amniotic Fluid
type: Class
subclass of: Fetus
MCID: MC00000803
PMOID: PMO:00000025
Subclass_of: Fetus
Synonym: AF - Amniotic fluid
Synonym: AMNIOTIC FLUID
Synonym: Amniotic Fluids
Synonym: Amniotic fluid
Synonym: Amniotic fluid (substance)
Synonym: Aqua Amnii
Synonym: FLUID, AMNIOTIC
Synonym: Fluid, Amniotic
Synonym: Fluids, Amniotic
Synonym: Liquor
Tree Number: T1.1.8.1
database_cross_reference: AOD:0000017039
database_cross_reference: CHV:0000001040
database_cross_reference: CSP:2404-0111
database_cross_reference: FMA:305905
database_cross_reference: LNC:LP208080-4
database_cross_reference: LNC:LP20977-2
database_cross_reference: LNC:MTHU001056
database_cross_reference: MSH:D000653
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13188
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13188
database_cross_reference: NCI_CDISC:SDTM-SPECTYPE
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: OMIM:MTHU001616
database_cross_reference: PSY:02130
database_cross_reference: RCD:X79bU
database_cross_reference: SNM:T-8Y300
database_cross_reference: SNMI:T-F1320
database_cross_reference: SNOMEDCT_US:256863002
database_cross_reference: SNOMEDCT_US:77012006

Fetal Blood
type: Class
subclass of: Fetus
MCID: MC00005066
PMOID: PMO:00000026
Subclass_of: Fetus
Synonym: Blood, Fetal
Synonym: Bloods, Fetal
Synonym: Fetal Bloods
Synonym: Fetal blood
Synonym: fetal blood
Tree Number: T1.1.8.2
database_cross_reference: CHV:0000004987
database_cross_reference: CSP:5000-0024
database_cross_reference: LCH:U001770
database_cross_reference: LCH_NW:sh85047943
database_cross_reference: LNC:LP62758-5
database_cross_reference: LNC:MTHU025654
database_cross_reference: MSH:D005312
database_cross_reference: MTH:NOCODE

Fetal Heart
type: Class
subclass of: Fetus
MCID: MC00005074
PMOID: PMO:00000027
Subclass_of: Fetus
Synonym: Fetal Hearts
Synonym: Fetal heart
Synonym: Heart, Fetal
Synonym: Hearts, Fetal
Synonym: fetal heart
Synonym: heart fetal
Tree Number: T1.1.8.3
database_cross_reference: CHV:0000004993
database_cross_reference: FMA:63931
database_cross_reference: LCH_NW:sh85047946
database_cross_reference: MSH:D005318
database_cross_reference: NCI:C34167

Ductus Arteriosus
type: Class
subclass of: Fetal Heart
MCID: MC00004201
PMOID: PMO:00000028
Subclass_of: Fetal Heart
Synonym: Arterial canal
Synonym: Arterial duct
Synonym: Arteriosus, Ductus
Synonym: Botallo's duct
Synonym: Ductus arteriosus
Synonym: Pulmoaortic canal
Synonym: Structure of ductus arteriosus
Synonym: Structure of ductus arteriosus (body structure)
Synonym: arterial canal
Synonym: arterial duct
Tree Number: T1.1.8.3.1
database_cross_reference: CHV:0000004171
database_cross_reference: CSP:0581-0789
database_cross_reference: CSP:2401-7877
database_cross_reference: FMA:79871
database_cross_reference: LCH:U001474
database_cross_reference: LCH_NW:sh85039885
database_cross_reference: LNC:LP7185-4
database_cross_reference: LNC:MTHU001509
database_cross_reference: MSH:D004373
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C52854
database_cross_reference: OMIM:MTHU002344
database_cross_reference: RCD:X781R
database_cross_reference: SNM:T-89645
database_cross_reference: SNMI:T-F6845
database_cross_reference: SNOMEDCT_US:4432005
database_cross_reference: UWDA:13421

Truncus Arteriosus
type: Class
subclass of: Fetal Heart
MCID: MC00013162
PMOID: PMO:00000029
Subclass_of: Fetal Heart
Synonym: Arteriosus, Truncus
Synonym: Common arterial trunk
Synonym: Structure of truncus arteriosus of fetus
Synonym: Structure of truncus arteriosus of fetus (body structure)
Synonym: Structure of truncus arteriosus of foetus
Synonym: TA - Truncus arteriosus
Synonym: TRUNCUS ARTERIOSUS
Synonym: Truncus arteriosus
Synonym: Truncus arteriosus of fetus
Synonym: Truncus arteriosus of foetus
Tree Number: T1.1.8.3.2
database_cross_reference: CHV:0000012603
database_cross_reference: FMA:70301
database_cross_reference: HPO:HP:0001660
database_cross_reference: LCH:U004795
database_cross_reference: LCH_NW:sh85138253
database_cross_reference: MSH:D014338
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:600584
database_cross_reference: OMIM:MTHU001442
database_cross_reference: RCD:XaBcz
database_cross_reference: SNM:T-89630
database_cross_reference: SNMI:T-F6830
database_cross_reference: SNOMEDCT_US:58140002

Endocardial Cushions
type: Class
subclass of: Fetal Heart
MCID: MC00077846
PMOID: PMO:00000030
Subclass_of: Fetal Heart
Synonym: Atrioventricular Canal Cushion
Synonym: Atrioventricular Canal Cushions
Synonym: Atrioventricular canal cushion
Synonym: Endocardial Cushion
Synonym: Endocardial cushion
Synonym: Structure of atrioventricular canal cushion
Synonym: Structure of atrioventricular canal cushion (body structure)
Synonym: endocardial cushion
Tree Number: T1.1.8.3.3
database_cross_reference: CHV:0000022598
database_cross_reference: FMA:70302
database_cross_reference: MSH:D054089
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-89650
database_cross_reference: SNMI:T-F6850
database_cross_reference: SNOMEDCT_US:68696006

Meconium
type: Class
subclass of: Fetus
MCID: MC00007953
PMOID: PMO:00000031
Subclass_of: Fetus
Synonym: Meconium (substance)
Synonym: Meconium stool
Synonym: Meconium stool (substance)
Synonym: Meconiums
Synonym: meconium
Synonym: meconium stool
Tree Number: T1.1.8.4
database_cross_reference: AOD:0000016844
database_cross_reference: CHV:0000007830
database_cross_reference: CSP:1248-7608
database_cross_reference: LCH:U002851
database_cross_reference: LCH_NW:sh85082793
database_cross_reference: LNC:LP19409-9
database_cross_reference: LNC:LP7413-0
database_cross_reference: LNC:MTHU001001
database_cross_reference: LNC:MTHU051573
database_cross_reference: MSH:D008470
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X79bf
database_cross_reference: SNM:T-8Y420
database_cross_reference: SNMI:T-F6B25
database_cross_reference: SNOMEDCT_US:256869003
database_cross_reference: SNOMEDCT_US:28112009

Umbilical Cord
type: Class
subclass of: Fetus
MCID: MC00013290
PMOID: PMO:00000032
Subclass_of: Fetus
Synonym: Cord, Umbilical
Synonym: Cords, Umbilical
Synonym: F18 UMBILICAL CORD
Synonym: UMBILICAL CORD
Synonym: Umbilical Cords
Synonym: Umbilical cord
Synonym: Umbilical cord structure
Synonym: Umbilical cord structure (body structure)
Synonym: Umbilical cord, NOS
Synonym: umbilical cord
Tree Number: T1.1.8.5
database_cross_reference: AOD:0000017036
database_cross_reference: CHV:0000012711
database_cross_reference: CSP:2403-6526
database_cross_reference: FMA:85541
database_cross_reference: LCH:U004843
database_cross_reference: LCH_NW:sh85139520
database_cross_reference: LNC:LP208557-1
database_cross_reference: LNC:LP7676-2
database_cross_reference: LNC:MTHU003060
database_cross_reference: MSH:D014470
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34320
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C34320
database_cross_reference: NCI_NICHD:C34320
database_cross_reference: RCD:Xa1UZ
database_cross_reference: SNM:T-88800
database_cross_reference: SNMI:T-F1800
database_cross_reference: SNOMEDCT_US:29870000

Umbilical Arteries
type: Class
subclass of: Umbilical Cord
MCID: MC00013289
PMOID: PMO:00000033
Subclass_of: Umbilical Cord
Synonym: Arteria umbilicalis
Synonym: Arteries, Umbilical
Synonym: Artery, Umbilical
Synonym: Structure of umbilical artery
Synonym: Structure of umbilical artery (body structure)
Synonym: Umbilical Artery
Synonym: Umbilical artery
Synonym: umbilical arteries
Synonym: umbilical artery
Tree Number: T1.1.8.5.1
database_cross_reference: CHV:0000012710
database_cross_reference: FMA:18820
database_cross_reference: LNC:LP208556-3
database_cross_reference: LNC:LP7671-3
database_cross_reference: LNC:MTHU024461
database_cross_reference: MSH:D014469
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33827
database_cross_reference: RCD:X90K9
database_cross_reference: SNM:T-88810
database_cross_reference: SNMI:T-F1810
database_cross_reference: SNOMEDCT_US:50536004
database_cross_reference: UWDA:18820

Umbilical Veins
type: Class
subclass of: Umbilical Cord
MCID: MC00013293
PMOID: PMO:00000034
Subclass_of: Umbilical Cord
Synonym: Structure of umbilical vein
Synonym: Structure of umbilical vein (body structure)
Synonym: Umbilical Vein
Synonym: Umbilical vein
Synonym: Umbilical vein (body structure)
Synonym: Umbilical vein, fetal
Synonym: Vein, Umbilical
Synonym: Veins, Umbilical
Synonym: Vena umbilicalis
Synonym: umbilical vein
Tree Number: T1.1.8.5.2
database_cross_reference: CHV:0000012713
database_cross_reference: CHV:0000022583
database_cross_reference: FMA:70317
database_cross_reference: LNC:LP7677-0
database_cross_reference: LNC:MTHU002917
database_cross_reference: MSH:D014471
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33830
database_cross_reference: RCD:X74hG
database_cross_reference: SNM:T-88820
database_cross_reference: SNM:T-89695
database_cross_reference: SNMI:T-F1820
database_cross_reference: SNOMEDCT_US:367567000

Vernix Caseosa
type: Class
subclass of: Fetus
MCID: MC00013534
PMOID: PMO:00000035
Subclass_of: Fetus
Synonym: Caseosa, Vernix
Synonym: Caseosas, Vernix
Synonym: Vernix
Synonym: Vernix Caseosa (substance)
Synonym: Vernix Caseosas
Synonym: Vernix caseosa
Synonym: Vernix caseosa (body structure)
Synonym: Vernix caseosa (substance)
Synonym: vernix caseosa
Tree Number: T1.1.8.6
database_cross_reference: CHV:0000012962
database_cross_reference: MSH:D014708
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34328
database_cross_reference: SNOMEDCT_US:416814000
database_cross_reference: SNOMEDCT_US:58480003

Aborted Fetus
type: Class
subclass of: Fetus
MCID: MC00000132
PMOID: PMO:00000036
Subclass_of: Fetus
Synonym: Aborted Embryo
Synonym: Aborted Embryos
Synonym: Aborted Fetus (structure)
Synonym: Aborted Fetuses
Synonym: Abortus
Synonym: Embryo, Aborted
Synonym: Embryos, Aborted
Synonym: Fetus under 500gms
Synonym: Fetus, Aborted
Synonym: Fetuses, Aborted
Tree Number: T1.1.8.7
database_cross_reference: CHV:0000000544
database_cross_reference: CHV:0000000559
database_cross_reference: MSH:D037881
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C73436
database_cross_reference: SNM:M-28000
database_cross_reference: SNMI:T-F5202
database_cross_reference: SNOMEDCT_US:28677006

Gastrula
type: Class
subclass of: Embryonic Structures
MCID: MC00005472
PMOID: PMO:00000037
Subclass_of: Embryonic Structures
Synonym: Gastrulas
Synonym: gastrula
Synonym: invaginate planula
Tree Number: T1.1.9
database_cross_reference: AOD:0000002025
database_cross_reference: AOD:0000021726
database_cross_reference: CSP:1016-6956
database_cross_reference: FMA:293108
database_cross_reference: MSH:D005775
database_cross_reference: NCI:C34057

Germ Layers
type: Class
subclass of: Embryonic Structures
MCID: MC00005580
PMOID: PMO:00000038
Subclass_of: Embryonic Structures
Synonym: Germ Layer
Synonym: Germ layer
Synonym: Layer, Germ
Synonym: Layers, Germ
Synonym: germ layer
Tree Number: T1.1.10
database_cross_reference: CSP:1016-7268
database_cross_reference: FMA:293071
database_cross_reference: MSH:D005855
database_cross_reference: MTH:NOCODE

Ectoderm
type: Class
subclass of: Germ Layers
MCID: MC00004293
PMOID: PMO:00000039
Subclass_of: Germ Layers
Synonym: Ectoderm structure
Synonym: Ectoderm structure (body structure)
Synonym: Ectoderm, NOS
Synonym: Ectodermal
Synonym: Ectoderms
Synonym: ectoderm
Tree Number: T1.1.10.1
database_cross_reference: CHV:0000004263
database_cross_reference: CSP:1016-7297
database_cross_reference: FMA:69070
database_cross_reference: MSH:D004475
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12703
database_cross_reference: SNM:T-89100
database_cross_reference: SNMI:T-F6100
database_cross_reference: SNOMEDCT_US:63206006

Endoderm
type: Class
subclass of: Germ Layers
MCID: MC00004447
PMOID: PMO:00000040
Subclass_of: Germ Layers
Synonym: Endoderm structure
Synonym: Endoderm structure (body structure)
Synonym: Endoderm, NOS
Synonym: Endoderms
Synonym: endoderm
Tree Number: T1.1.10.2
database_cross_reference: CHV:0000004454
database_cross_reference: CSP:1016-7373
database_cross_reference: FMA:69071
database_cross_reference: MSH:D004707
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12706
database_cross_reference: SNM:T-89400
database_cross_reference: SNMI:T-F6600
database_cross_reference: SNOMEDCT_US:55259008

Mesoderm
type: Class
subclass of: Germ Layers
MCID: MC00008107
PMOID: PMO:00000041
Subclass_of: Germ Layers
Synonym: Mesoderm structure
Synonym: Mesoderm structure (body structure)
Synonym: Mesoderm, NOS
Synonym: mesoderm
Tree Number: T1.1.10.3
database_cross_reference: CHV:0000007989
database_cross_reference: CSP:1016-7414
database_cross_reference: FMA:69072
database_cross_reference: LCH:U002920
database_cross_reference: LCH_NW:sh85083937
database_cross_reference: MSH:D008648
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12750
database_cross_reference: SNM:T-89200
database_cross_reference: SNMI:T-F6300
database_cross_reference: SNOMEDCT_US:64927000

Somites
type: Class
subclass of: Mesoderm
MCID: MC00133342
PMOID: PMO:00000042
Subclass_of: Mesoderm
Synonym: Somite
Synonym: somite
Synonym: somites
Tree Number: T1.1.10.3.1
database_cross_reference: CHV:0000031779
database_cross_reference: FMA:85522
database_cross_reference: LCH_NW:sh85124799
database_cross_reference: MSH:D019170
database_cross_reference: NCI:C34302

Pericytes
type: Class
subclass of: Mesoderm
subclass of: Endothelium
subclass of: Cell
MCID: MC00183701
PMOID: PMO:00000043
Subclass_of: Cell
Subclass_of: Endothelium
Subclass_of: Mesoderm
Synonym: Adventitial Cell
Synonym: Adventitial cell
Synonym: Cell of Rouget
Synonym: Cells, Rouget
Synonym: Pericapillary Cell
Synonym: Pericyte
Synonym: Pericyte of Rouget
Synonym: Pericyte of Rouget (cell)
Synonym: Perivascular Cell
Synonym: Rouget Cell
Tree Number: T1.1.10.3.2
Tree Number: T1.3.5.2.4
Tree Number: T2.26
database_cross_reference: AOD:0000017511
database_cross_reference: CHV:0000041942
database_cross_reference: CSP:0432-6461
database_cross_reference: FMA:63174
database_cross_reference: FMA:84639
database_cross_reference: MSH:D020286
database_cross_reference: NCI:C12656
database_cross_reference: SNM:T-1X320
database_cross_reference: SNMI:T-1A520
database_cross_reference: SNOMEDCT_US:34773004
database_cross_reference: UWDA:63174

Mesonephros
type: Class
subclass of: Embryonic Structures
MCID: MC00008109
PMOID: PMO:00000044
Subclass_of: Embryonic Structures
Synonym: Body, Wolffian
Synonym: Mesonephric structure
Synonym: Mesonephric structure (body structure)
Synonym: Mesonephroi
Synonym: Wolffian Body
Synonym: Wolffian body
Tree Number: T1.1.11
database_cross_reference: FMA:72171
database_cross_reference: LCH_NW:sh85147231
database_cross_reference: MSH:D008650
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26467
database_cross_reference: SNM:T-89350
database_cross_reference: SNMI:T-F6450
database_cross_reference: SNOMEDCT_US:21241002

Morula
type: Class
subclass of: Embryonic Structures
MCID: MC00008419
PMOID: PMO:00000045
Subclass_of: Embryonic Structures
Synonym: Morula (Embryonic Structure)
Synonym: Morula (body structure)
Synonym: Morulas
Synonym: morula
Tree Number: T1.1.12
database_cross_reference: CHV:0000008259
database_cross_reference: FMA:292334
database_cross_reference: MSH:D009028
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34212
database_cross_reference: SNOMEDCT_US:361474003

Mullerian Ducts
type: Class
subclass of: Embryonic Structures
MCID: MC00008465
PMOID: PMO:00000046
Subclass_of: Embryonic Structures
Synonym: Ducts, Mullerian
Synonym: Mullerian Duct
Synonym: Mullerian duct
Synonym: Müllerian Duct
Synonym: Paramesonephric Duct
Synonym: Paramesonephric duct
Synonym: Structure of paramesonephric duct
Synonym: Structure of paramesonephric duct (body structure)
Synonym: mullerian duct
Synonym: mullerian ducts
Tree Number: T1.1.13
database_cross_reference: CHV:0000008320
database_cross_reference: MSH:D009095
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13260
database_cross_reference: SNM:T-89390
database_cross_reference: SNMI:T-F6490
database_cross_reference: SNOMEDCT_US:26896004

Neural Crest
type: Class
subclass of: Embryonic Structures
MCID: MC00008802
PMOID: PMO:00000047
Subclass_of: Embryonic Structures
Synonym: Crest, Neural
Synonym: Crests, Neural
Synonym: Neural Crests
Synonym: Neural crest
Synonym: Neural crest (body structure)
Synonym: crest neural
Synonym: neural crest
Tree Number: T1.1.14
database_cross_reference: AOD:0000017031
database_cross_reference: CHV:0000008614
database_cross_reference: CSP:1016-7322
database_cross_reference: FMA:86666
database_cross_reference: LCH:U003175
database_cross_reference: LCH_NW:sh85091092
database_cross_reference: MSH:D009432
database_cross_reference: NCI:C34222
database_cross_reference: NEU:1366
database_cross_reference: SNOMEDCT_US:361462002

Notochord
type: Class
subclass of: Embryonic Structures
MCID: MC00009025
PMOID: PMO:00000048
Subclass_of: Embryonic Structures
Synonym: Chorda dorsalis
Synonym: Chordamesoderm
Synonym: Notochords
Synonym: Structure of notochord
Synonym: Structure of notochord (body structure)
Synonym: notochord
Tree Number: T1.1.15
database_cross_reference: CHV:0000008790
database_cross_reference: FMA:85521
database_cross_reference: LCH:U003269
database_cross_reference: LCH_NW:sh85092813
database_cross_reference: MSH:D009672
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12463
database_cross_reference: SNM:T-89310
database_cross_reference: SNMI:T-F6410
database_cross_reference: SNOMEDCT_US:37222002

Ovum
type: Class
subclass of: Embryonic Structures
subclass of: Germ Cells
MCID: MC00009543
PMOID: PMO:00000049
Subclass_of: Embryonic Structures
Subclass_of: Germ Cells
Synonym: Egg
Synonym: Egg (cell)
Synonym: Egg, NOS
Synonym: Egg, Unfertilized
Synonym: Eggs, Unfertilized
Synonym: Female gamete
Synonym: Fertilized oocyte
Synonym: Human egg
Synonym: Mature ovum
Synonym: Oocytes
Tree Number: T1.1.16
Tree Number: T2.15.2
database_cross_reference: AOD:0000017390
database_cross_reference: CHV:0000009132
database_cross_reference: CSP:1138-3157
database_cross_reference: DRUGBANK:DB10529
database_cross_reference: FMA:67343
database_cross_reference: LCH:U003418
database_cross_reference: LCH_NW:sh85096271
database_cross_reference: LNC:LP14834-3
database_cross_reference: LNC:LP30698-2
database_cross_reference: LNC:LP7192-0
database_cross_reference: LNC:MTHU009318
database_cross_reference: MSH:D010063
database_cross_reference: MTH:U002129
database_cross_reference: NCI:C12598
database_cross_reference: RCD:XC0AT
database_cross_reference: SNM:T-87500
database_cross_reference: SNMI:T-87500
database_cross_reference: SNMI:T-87501
database_cross_reference: SNOMEDCT_US:263828003
database_cross_reference: SNOMEDCT_US:308796009
database_cross_reference: SNOMEDCT_US:60080006
database_cross_reference: SNOMEDCT_US:73153001
database_cross_reference: UWDA:67343

Egg Yolk
type: Class
subclass of: Ovum
MCID: MC01077131
PMOID: PMO:00000050
Subclass_of: Ovum
Synonym: Egg yolk
Synonym: Food - Animal Products and Poultry Products, Egg, Yolk Gallus sp.
Tree Number: T1.1.16.1
database_cross_reference: DRUGBANK:DB10530

Vitelline Membrane
type: Class
subclass of: Ovum
MCID: MC00013642
PMOID: PMO:00000051
Subclass_of: Ovum
Synonym: Membrane, Vitelline
Synonym: Membranes, Vitelline
Synonym: Vitelline Membranes
Synonym: vitelline membrane
Tree Number: T1.1.16.2
database_cross_reference: CSP:2404-6229
database_cross_reference: GO:GO:0035805
database_cross_reference: MSH:D014817

Zona Pellucida
type: Class
subclass of: Ovum
subclass of: Extracellular Matrix
MCID: MC00013832
PMOID: PMO:00000052
Subclass_of: Extracellular Matrix
Subclass_of: Ovum
Synonym: Zona pellucida
Synonym: zona pellucida
Tree Number: T1.1.16.3
Tree Number: T1.4.5.2.1
Tree Number: T2.15.2.3
Tree Number: T2.8.5.2.1
database_cross_reference: CHV:0000013283
database_cross_reference: CSP:1138-3157
database_cross_reference: FMA:18674
database_cross_reference: GO:GO:0035805
database_cross_reference: LCH_NW:sh88007451
database_cross_reference: MSH:D015044
database_cross_reference: NCI:C33896
database_cross_reference: UWDA:18674

Placenta
type: Class
subclass of: Embryonic Structures
MCID: MC00010271
PMOID: PMO:00000053
Subclass_of: Embryonic Structures
Synonym: PLACENTA
Synonym: Placent
Synonym: Placenta, NOS
Synonym: Placental
Synonym: Placental structure
Synonym: Placental structure (body structure)
Synonym: Placentas
Synonym: Placentoma, Normal
Synonym: Placentome
Synonym: Placentomes
Tree Number: T1.1.17
database_cross_reference: AOD:0000017034
database_cross_reference: CHV:0000009778
database_cross_reference: CSP:2402-4971
database_cross_reference: CST:ENDO/PLAC
database_cross_reference: FMA:63934
database_cross_reference: LCH:U003693
database_cross_reference: LCH_NW:sh85102565
database_cross_reference: LNC:LP200062-0
database_cross_reference: LNC:LP20772-7
database_cross_reference: LNC:LP208379-0
database_cross_reference: LNC:LP7477-5
database_cross_reference: LNC:LP7484-1
database_cross_reference: LNC:MTHU002985
database_cross_reference: MSH:D010920
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13272
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13272
database_cross_reference: NCI_NCI-GLOSS:CDR0000045017
database_cross_reference: PSY:39040
database_cross_reference: RCD:7N613
database_cross_reference: SNM:T-88100
database_cross_reference: SNMI:T-F1100
database_cross_reference: SNMI:T-F1550
database_cross_reference: SNOMEDCT_US:62669004
database_cross_reference: SNOMEDCT_US:78067005
database_cross_reference: SNOMEDCT_VET:345231000009100

Decidua
type: Class
subclass of: Placenta
MCID: MC00003564
PMOID: PMO:00000054
Subclass_of: Placenta
Synonym: Decidous membrane
Synonym: Decidua Graviditas
Synonym: Decidua structure
Synonym: Decidua structure (body structure)
Synonym: Decidua, NOS
Synonym: Decidual
Synonym: Deciduas
Synonym: Deciduum
Synonym: Endometrial decidua
Synonym: Endometrial decidua (body structure)
Tree Number: T1.1.17.2
database_cross_reference: CHV:0000003643
database_cross_reference: CSP:4001-0037
database_cross_reference: FMA:85538
database_cross_reference: LCH:U001282
database_cross_reference: LCH_NW:sh86005483
database_cross_reference: MSH:D003656
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32425
database_cross_reference: SNM:T-84500
database_cross_reference: SNM:T-88205
database_cross_reference: SNMI:T-83480
database_cross_reference: SNMI:T-F1205
database_cross_reference: SNOMEDCT_US:34863009
database_cross_reference: SNOMEDCT_US:72649005

Deciduoma
type: Class
subclass of: Decidua
MCID: MC00163837
PMOID: PMO:00000055
Subclass_of: Decidua
Synonym: Deciduomas
Synonym: Neoplasm of Placenta
Synonym: Neoplasm of placenta
Synonym: Neoplasm of placenta (disorder)
Synonym: Neoplasm of the Placenta
Synonym: Placenta Neoplasm
Synonym: Placenta Neoplasms
Synonym: Placenta Tumor
Synonym: Placenta Tumors
Synonym: Placental Neoplasm
Tree Number: T1.1.17.2.1
database_cross_reference: CSP:2403-0590
database_cross_reference: MDR:10035140
database_cross_reference: MDR:10035141
database_cross_reference: MDR:10061349
database_cross_reference: MEDCIN:97460
database_cross_reference: MSH:D033301
database_cross_reference: NCI:C4858
database_cross_reference: SNOMEDCT_US:126920004

Urachus
type: Class
subclass of: Embryonic Structures
MCID: MC00013332
PMOID: PMO:00000056
Subclass_of: Embryonic Structures
Synonym: Structure of urachus
Synonym: Structure of urachus (body structure)
Synonym: median umbilical ligament
Synonym: urachus
Tree Number: T1.1.18
database_cross_reference: CHV:0000012746
database_cross_reference: FMA:70343
database_cross_reference: LCH:U004846
database_cross_reference: LCH_NW:sh85141256
database_cross_reference: MSH:D014497
database_cross_reference: MTH:U002335
database_cross_reference: NCI:C12338
database_cross_reference: NCI_NCI-GLOSS:CDR0000044354
database_cross_reference: NCI_NCI-GLOSS:CDR0000520556
database_cross_reference: RCD:Xa0EV
database_cross_reference: SNM:T-74120
database_cross_reference: SNMI:T-F6625
database_cross_reference: SNOMEDCT_US:14105008
database_cross_reference: UWDA:70343

Vitelline Duct
type: Class
subclass of: Embryonic Structures
MCID: MC00013641
PMOID: PMO:00000057
Subclass_of: Embryonic Structures
Synonym: Duct, Omphalomesenteric
Synonym: Duct, Vitelline
Synonym: Ducts, Omphalomesenteric
Synonym: Ducts, Vitelline
Synonym: Omphalomesenteric Duct
Synonym: Omphalomesenteric Ducts
Synonym: Omphalomesenteric duct
Synonym: Structure of yolk stalk
Synonym: Structure of yolk stalk (body structure)
Synonym: Vitelline Ducts
Tree Number: T1.1.19
database_cross_reference: CHV:0000013063
database_cross_reference: MSH:D014816
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-88450
database_cross_reference: SNM:T-88850
database_cross_reference: SNMI:T-F1450
database_cross_reference: SNOMEDCT_US:41629008

Wolffian Ducts
type: Class
subclass of: Embryonic Structures
MCID: MC00013732
PMOID: PMO:00000058
Subclass_of: Embryonic Structures
Synonym: Duct, Mesonephric
Synonym: Duct, Wolffian
Synonym: Ducts, Mesonephric
Synonym: Ducts, Wolffian
Synonym: Mesonephric Duct
Synonym: Mesonephric Ducts
Synonym: Mesonephric duct
Synonym: Structure of mesonephric duct
Synonym: Structure of mesonephric duct (body structure)
Synonym: Wolffian Duct
Tree Number: T1.1.20
database_cross_reference: CHV:0000013177
database_cross_reference: MSH:D014928
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26469
database_cross_reference: SNM:T-89360
database_cross_reference: SNMI:T-F6460
database_cross_reference: SNOMEDCT_US:49222007

Zygote
type: Class
subclass of: Embryonic Structures
subclass of: Ovum
MCID: MC00013838
PMOID: PMO:00000059
Subclass_of: Embryonic Structures
Subclass_of: Ovum
Synonym: Egg, Fertilized
Synonym: Eggs, Fertilized
Synonym: Fertilised ovum
Synonym: Fertilized Egg
Synonym: Fertilized Eggs
Synonym: Fertilized Ovum
Synonym: Fertilized Ovums
Synonym: Fertilized ovum
Synonym: Ovum, Fertilized
Synonym: Structure of zygote
Tree Number: T1.1.21
Tree Number: T2.15.2.4
database_cross_reference: AOD:0000002008
database_cross_reference: AOD:0000021684
database_cross_reference: AOD:0000021685
database_cross_reference: CHV:0000013291
database_cross_reference: FMA:72395
database_cross_reference: LCH:U005093
database_cross_reference: LCH_NW:sh85150089
database_cross_reference: MSH:D015053
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12601
database_cross_reference: SNM:T-88150
database_cross_reference: SNM:T-89005
database_cross_reference: SNMI:T-F5106
database_cross_reference: SNOMEDCT_US:57323001
database_cross_reference: UWDA:72395

Limb Buds
type: Class
subclass of: Embryonic Structures
MCID: MC00098958
PMOID: PMO:00000060
Subclass_of: Embryonic Structures
Synonym: Bud, Limb
Synonym: Buds, Limb
Synonym: Limb Bud
Synonym: Limb bud
Synonym: limb bud
Tree Number: T1.1.22
database_cross_reference: CHV:0000027618
database_cross_reference: FMA:296780
database_cross_reference: MSH:D018878
database_cross_reference: NCI:C34203

Organizers, Embryonic
type: Class
subclass of: Embryonic Structures
MCID: MC00259302
PMOID: PMO:00000061
Subclass_of: Embryonic Structures
Synonym: Embryo Organizer
Synonym: Embryo Organizers
Synonym: Embryonic Organizer
Synonym: Embryonic Organizers
Synonym: Organizer, Embryo
Synonym: Organizer, Embryonic
Synonym: Organizers, Embryo
Tree Number: T1.1.23
database_cross_reference: MSH:D020897

Primitive Streak
type: Class
subclass of: Embryonic Structures
MCID: MC00010626
PMOID: PMO:00000062
Subclass_of: Embryonic Structures
Synonym: Primitive Streaks
Synonym: Primitive streak
Synonym: Primitive streak (body structure)
Synonym: Streak, Primitive
Synonym: Streaks, Primitive
Tree Number: T1.1.24
database_cross_reference: FMA:293110
database_cross_reference: MSH:D054240
database_cross_reference: NCI:C28402
database_cross_reference: SNOMEDCT_US:361438007

Neural Plate
type: Class
subclass of: Embryonic Structures
MCID: MC00323283
PMOID: PMO:00000063
Subclass_of: Embryonic Structures
Synonym: Neural Plates
Synonym: Neural plate
Synonym: Plate, Neural
Synonym: Plates, Neural
Synonym: neural plate
Tree Number: T1.1.25
database_cross_reference: CHV:0000052618
database_cross_reference: CSP:1016-7347
database_cross_reference: FMA:293879
database_cross_reference: MSH:D054258
database_cross_reference: NCI:C34225
database_cross_reference: NEU:1362

Neural Tube
type: Class
subclass of: Embryonic Structures
MCID: MC00077793
PMOID: PMO:00000064
Subclass_of: Embryonic Structures
Synonym: Embryonic neuraxis
Synonym: Neural Tubes
Synonym: Neural tube
Synonym: Neural tube structure
Synonym: Neural tube structure (body structure)
Synonym: Tube, Neural
Synonym: Tubes, Neural
Synonym: medullary tube
Synonym: neural tube
Synonym: neural tubes
Tree Number: T1.1.26
database_cross_reference: AOD:0000017027
database_cross_reference: AOD:0000027665
database_cross_reference: CHV:0000022591
database_cross_reference: CSP:1016-7347
database_cross_reference: FMA:293882
database_cross_reference: LCH_NW:sh85091098
database_cross_reference: MSH:D054259
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34226
database_cross_reference: NEU:1365
database_cross_reference: SNM:T-89110
database_cross_reference: SNMI:T-F6110
database_cross_reference: SNOMEDCT_US:60271003

Gestational Sac
type: Class
subclass of: Embryonic Structures
MCID: MC00173307
PMOID: PMO:00000065
Subclass_of: Embryonic Structures
Synonym: Gestation Sac
Synonym: Gestation Sacs
Synonym: Gestational Sacs
Synonym: Gestational sac
Synonym: Sac, Gestation
Synonym: Sac, Gestational
Synonym: Sacs, Gestation
Synonym: Sacs, Gestational
Synonym: gestational sac
Synonym: sac gestational
Tree Number: T1.1.27
database_cross_reference: CHV:0000039073
database_cross_reference: LNC:LP7273-8
database_cross_reference: LNC:MTHU002950
database_cross_reference: MSH:D058746
database_cross_reference: NCI:C82951

Pronephros
type: Class
subclass of: Embryonic Structures
MCID: MC00077817
PMOID: PMO:00000066
Subclass_of: Embryonic Structures
Synonym: Pronephric structure
Synonym: Pronephric structure (body structure)
Synonym: Pronephroi
Tree Number: T1.1.28
database_cross_reference: FMA:72170
database_cross_reference: MSH:D060910
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34280
database_cross_reference: SNM:T-89340
database_cross_reference: SNMI:T-F6440
database_cross_reference: SNOMEDCT_US:16421008

Head Kidney
type: Class
subclass of: Pronephros
MCID: MC00831060
PMOID: PMO:00000067
Subclass_of: Pronephros
Synonym: Anterior Kidney
Synonym: Anterior Kidneys
Synonym: Head Kidneys
Synonym: Kidney, Anterior
Synonym: Kidney, Head
Synonym: Kidneys, Anterior
Synonym: Kidneys, Head
Tree Number: T1.1.28.1
database_cross_reference: MSH:D060226

Body Regions
type: Class
subclass of: Anatomical Structure
PMOID: PMO:00000068
Subclass_of: Anatomical Structure
Tree Number: T1.2

Breast
type: Class
subclass of: Body Regions
MCID: MC00001927
PMOID: PMO:00000069
Subclass_of: Body Regions
Synonym: 04 BREASTS
Synonym: BREAST
Synonym: BREASTS
Synonym: Breast anatomy
Synonym: Breast anatomy (body structure)
Synonym: Breast structure
Synonym: Breast structure (body structure)
Synonym: Breast, NOS
Synonym: Breasts
Synonym: Mamma
Tree Number: T1.2.1
database_cross_reference: AOD:0000001800
database_cross_reference: CCPSS:0003968
database_cross_reference: CHV:0000002151
database_cross_reference: CSP:2587-3889
database_cross_reference: FMA:9601
database_cross_reference: LCH:U000673
database_cross_reference: LCH_NW:sh85016677
database_cross_reference: LNC:LA4255-1
database_cross_reference: LNC:LP199961-6
database_cross_reference: LNC:LP29849-4
database_cross_reference: LNC:LP7086-4
database_cross_reference: LNC:MTHU001046
database_cross_reference: LNC:MTHU011382
database_cross_reference: MSH:D001940
database_cross_reference: MTH:U001764
database_cross_reference: NCI:C12971
database_cross_reference: NCI:C43595
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12971
database_cross_reference: NCI_NCI-GLOSS:CDR0000044560
database_cross_reference: NCI_NCI-GLOSS:CDR0000304766
database_cross_reference: NCI_NICHD:C12971
database_cross_reference: OMIM:MTHU001433
database_cross_reference: PSY:06920
database_cross_reference: RCD:7N12.
database_cross_reference: RCD:XM0QG
database_cross_reference: SNM:T-04000
database_cross_reference: SNM:U000415
database_cross_reference: SNMI:T-04000
database_cross_reference: SNOMEDCT_US:272669003
database_cross_reference: SNOMEDCT_US:361079003
database_cross_reference: SNOMEDCT_US:76752008
database_cross_reference: UWDA:9601

Nipples
type: Class
subclass of: Breast
MCID: MC00008911
PMOID: PMO:00000070
Subclass_of: Breast
Synonym: NIPPLE
Synonym: Nipple
Synonym: Nipple (Anatomy)
Synonym: Nipple (body structure)
Synonym: Nipple anatomy
Synonym: Nipple anatomy (body structure)
Synonym: Nipple structure
Synonym: Nipple structure (body structure)
Synonym: Papilla mammaria
Synonym: Papillary part of breast
Tree Number: T1.2.1.1
database_cross_reference: AOD:0000017152
database_cross_reference: CHV:0000008725
database_cross_reference: FMA:67771
database_cross_reference: LCH_NW:sh2009007031
database_cross_reference: MSH:D009558
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12299
database_cross_reference: NCI_CDISC:C12299
database_cross_reference: NCI_NCI-GLOSS:CDR0000304735
database_cross_reference: NCI_NICHD:C12299
database_cross_reference: RCD:XE0Jw
database_cross_reference: RCD:Xa0wF
database_cross_reference: SNM:T-04100
database_cross_reference: SNMI:T-04100
database_cross_reference: SNOMEDCT_US:24142002
database_cross_reference: SNOMEDCT_US:279007000
database_cross_reference: SNOMEDCT_US:361080000
database_cross_reference: SNOMEDCT_US:367340005
database_cross_reference: UMD:33-768
database_cross_reference: UWDA:67771

Mammary Glands, Human
type: Class
subclass of: Breast
subclass of: Exocrine Glands
MCID: MC00329926
PMOID: PMO:00000071
Subclass_of: Breast
Subclass_of: Exocrine Glands
Synonym: Gland, Human Mammary
Synonym: Gland, Mammary
Synonym: Glands, Human Mammary
Synonym: Glands, Mammary
Synonym: Glandula mammaria
Synonym: Human Mammary Gland
Synonym: Human Mammary Glands
Synonym: MAMMARY GLAND
Synonym: Mammary
Synonym: Mammary Gland
Tree Number: T1.2.1.2
Tree Number: T1.3.6.9
database_cross_reference: AOD:0000027713
database_cross_reference: CHV:0000052712
database_cross_reference: CSP:2587-3889
database_cross_reference: FMA:286452
database_cross_reference: FMA:57983
database_cross_reference: LCH_NW:sh85080275
database_cross_reference: MSH:D042361
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12367
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12367
database_cross_reference: NCI_NCI-GLOSS:CDR0000415575
database_cross_reference: NCI_NICHD:C12367
database_cross_reference: PSY:29320
database_cross_reference: RCD:7N12.
database_cross_reference: SNM:T-04000
database_cross_reference: SNMI:T-04000
database_cross_reference: SNOMEDCT_US:76752008
database_cross_reference: SNOMEDCT_VET:277791000009109
database_cross_reference: UWDA:57983

Extremities
type: Class
subclass of: Body Regions
MCID: MC00004890
PMOID: PMO:00000072
Subclass_of: Body Regions
Synonym: Extremities (Anatomy)
Synonym: Extremity
Synonym: Extremity (body structure)
Synonym: Extremity -RETIRED-
Synonym: Extremity, NOS
Synonym: LIMB
Synonym: Limb
Synonym: Limb structure
Synonym: Limb structure (body structure)
Synonym: Limb, NOS
Tree Number: T1.2.2
database_cross_reference: AOD:0000004703
database_cross_reference: AOD:0000017103
database_cross_reference: CHV:0000004807
database_cross_reference: CSP:2715-5305
database_cross_reference: FMA:7182
database_cross_reference: LCH:U006431
database_cross_reference: LCH_NW:sh85046619
database_cross_reference: LNC:LA3977-1
database_cross_reference: LNC:LP121777-9
database_cross_reference: LNC:LP199969-9
database_cross_reference: LNC:LP29945-0
database_cross_reference: LNC:LP7216-7
database_cross_reference: LNC:LP7395-9
database_cross_reference: LNC:MTHU001429
database_cross_reference: LNC:MTHU002838
database_cross_reference: LNC:MTHU011975
database_cross_reference: MSH:D005121
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12429
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12429
database_cross_reference: NCI_NICHD:C12429
database_cross_reference: OMIM:MTHU000040
database_cross_reference: RCD:X74Yt
database_cross_reference: RCD:Xa1Z8
database_cross_reference: SNM:T-Y1800
database_cross_reference: SNMI:T-D0300
database_cross_reference: SNOMEDCT_US:123169005
database_cross_reference: SNOMEDCT_US:66019005
database_cross_reference: UWDA:7182

Amputation Stumps
type: Class
subclass of: Extremities
MCID: MC00000821
PMOID: PMO:00000073
Subclass_of: Extremities
Synonym: Amputation Stump
Synonym: Amputation stump
Synonym: Amputation stump (body structure)
Synonym: Amputation stump (morphologic abnormality)
Synonym: Amputation stumps
Synonym: Stump
Synonym: Stump, Amputation
Synonym: Stumps, Amputation
Synonym: amputation stump
Synonym: stump
Tree Number: T1.2.2.1
database_cross_reference: AOD:0000008176
database_cross_reference: CHV:0000001056
database_cross_reference: LCH:U000215
database_cross_reference: MSH:D000672
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C96294
database_cross_reference: RCD:Xa9LR
database_cross_reference: SNM:M-14850
database_cross_reference: SNMI:M-17080
database_cross_reference: SNOMEDCT_US:38033009

Upper Extremity
type: Class
subclass of: Extremities
MCID: MC00380499
PMOID: PMO:00000074
Subclass_of: Extremities
Synonym: Arm
Synonym: D8 UPPER EXTREMITIES
Synonym: Extremities, Upper
Synonym: Extremity, Upper
Synonym: Extremity-upper
Synonym: FORELIMB
Synonym: Fore limb
Synonym: Forelimb
Synonym: Forelimb, NOS
Synonym: LIMB, UPPER
Tree Number: T1.2.2.2
database_cross_reference: AOD:0000027657
database_cross_reference: AOD:0000027658
database_cross_reference: CHV:0000055073
database_cross_reference: CSP:2715-5391
database_cross_reference: CST:BODY/UE
database_cross_reference: FMA:7183
database_cross_reference: LCH:U006433
database_cross_reference: LNC:LA18113-3
database_cross_reference: LNC:LP200031-5
database_cross_reference: LNC:LP207499-7
database_cross_reference: LNC:LP29957-5
database_cross_reference: LNC:MTHU011974
database_cross_reference: MSH:D034941
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12671
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12671
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C12671
database_cross_reference: RCD:Xa1ZA
database_cross_reference: SNM:T-Y8000
database_cross_reference: SNM:U000523
database_cross_reference: SNMI:T-D8000
database_cross_reference: SNOMEDCT_US:53120007
database_cross_reference: UWDA:7183

Arm
type: Class
subclass of: Upper Extremity
MCID: MC00380499
PMOID: PMO:00000075
Subclass_of: Upper Extremity
Synonym: D8 UPPER EXTREMITIES
Synonym: Extremities, Upper
Synonym: Extremity, Upper
Synonym: Extremity-upper
Synonym: FORELIMB
Synonym: Fore limb
Synonym: Forelimb
Synonym: Forelimb, NOS
Synonym: LIMB, UPPER
Synonym: Limb, Upper
Tree Number: T1.2.2.2.1
database_cross_reference: AOD:0000027657
database_cross_reference: AOD:0000027658
database_cross_reference: CHV:0000055073
database_cross_reference: CSP:2715-5391
database_cross_reference: CST:BODY/UE
database_cross_reference: FMA:7183
database_cross_reference: LCH:U006433
database_cross_reference: LNC:LA18113-3
database_cross_reference: LNC:LP200031-5
database_cross_reference: LNC:LP207499-7
database_cross_reference: LNC:LP29957-5
database_cross_reference: LNC:MTHU011974
database_cross_reference: MSH:D034941
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12671
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12671
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C12671
database_cross_reference: RCD:Xa1ZA
database_cross_reference: SNM:T-Y8000
database_cross_reference: SNM:U000523
database_cross_reference: SNMI:T-D8000
database_cross_reference: SNOMEDCT_US:53120007
database_cross_reference: UWDA:7183

Axilla
type: Class
subclass of: Upper Extremity
MCID: MC00430668
PMOID: PMO:00000076
Subclass_of: Upper Extremity
Synonym: Entire axilla
Synonym: Entire axilla (body structure)
Tree Number: T1.2.2.2.2
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:182333009

Elbow
type: Class
subclass of: Upper Extremity
MCID: MC00441598
PMOID: PMO:00000077
Subclass_of: Upper Extremity
Synonym: Elbow, NOS
Synonym: Entire elbow
Synonym: Entire elbow region
Synonym: Entire elbow region (body structure)
Tree Number: T1.2.2.2.3
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:T-D8300
database_cross_reference: SNOMEDCT_US:76248009

Forearm
type: Class
subclass of: Upper Extremity
MCID: MC00005257
PMOID: PMO:00000078
Subclass_of: Upper Extremity
Synonym: Antebrachial region
Synonym: Antebrachium
Synonym: Antebrachiums
Synonym: FOREARM
Synonym: Forearm structure
Synonym: Forearm structure (body structure)
Synonym: Forearm, NOS
Synonym: Forearms
Synonym: Intermediate segment of free upper limb
Synonym: Pair of forearm
Tree Number: T1.2.2.2.4
database_cross_reference: AOD:0000017007
database_cross_reference: CCPSS:0025868
database_cross_reference: CHV:0000005202
database_cross_reference: FMA:268887
database_cross_reference: FMA:9663
database_cross_reference: LCH:U001855
database_cross_reference: LCH_NW:sh85050484
database_cross_reference: LNC:LP199974-9
database_cross_reference: LNC:LP207500-2
database_cross_reference: LNC:LP7249-8
database_cross_reference: LNC:MTHU002680
database_cross_reference: MSH:D005542
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32628
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C32628
database_cross_reference: NCI_NICHD:C32628
database_cross_reference: RCD:Xa8Ss
database_cross_reference: SNM:T-Y8500
database_cross_reference: SNMI:T-D8500
database_cross_reference: SNOMEDCT_US:14975008
database_cross_reference: SNOMEDCT_VET:14975008
database_cross_reference: UWDA:9663

Hand
type: Class
subclass of: Upper Extremity
MCID: MC00005936
PMOID: PMO:00000079
Subclass_of: Upper Extremity
Synonym: HAND
Synonym: Hand (Anatomy)
Synonym: Hand, NOS
Synonym: Hands
Synonym: Manus
Synonym: Terminal segment of free upper limb
Synonym: hand
Synonym: hand structure
Synonym: hands
Synonym: manus
Tree Number: T1.2.2.2.5
database_cross_reference: AOD:0000002469
database_cross_reference: CHV:0000005789
database_cross_reference: CSP:2715-5520
database_cross_reference: DRUGBANK:DB00898
database_cross_reference: DRUGBANK:DB08604
database_cross_reference: FMA:9712
database_cross_reference: LCH:U002075
database_cross_reference: LCH_NW:sh85058615
database_cross_reference: LNC:LA16719-9
database_cross_reference: LNC:LP207503-6
database_cross_reference: LNC:LP221491-6
database_cross_reference: LNC:LP7279-5
database_cross_reference: LNC:MTHU002685
database_cross_reference: MSH:D006225
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32712
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C32712
database_cross_reference: NCI_NICHD:C32712
database_cross_reference: OMIM:MTHU000072
database_cross_reference: PSY:22200
database_cross_reference: RCD:Xa8St
database_cross_reference: SNM:T-Y8700
database_cross_reference: SNMI:T-D8700
database_cross_reference: SNOMEDCT_US:85562004
database_cross_reference: UWDA:9712

Shoulder
type: Class
subclass of: Upper Extremity
PMOID: PMO:00000084
Subclass_of: Upper Extremity
Tree Number: T1.2.2.2.6

Lower Extremity
type: Class
subclass of: Extremities
MCID: MC00007421
PMOID: PMO:00000085
Subclass_of: Extremities
Synonym: D9 LOWER EXTREMITIES
Synonym: Extremities, Lower
Synonym: Extremity, Lower
Synonym: Extremity-lower
Synonym: HINDLIMB
Synonym: Hind Limb
Synonym: Hind limb
Synonym: Hindlimb
Synonym: Hindlimb, NOS
Synonym: Hindquarter
Tree Number: T1.2.2.3
database_cross_reference: AOD:0000027660
database_cross_reference: AOD:0000027661
database_cross_reference: CCPSS:1001127
database_cross_reference: CHV:0000007269
database_cross_reference: CST:BODY/LE
database_cross_reference: FMA:7184
database_cross_reference: LCH:U006432
database_cross_reference: LNC:LA18112-5
database_cross_reference: LNC:LP199985-5
database_cross_reference: LNC:LP207495-5
database_cross_reference: LNC:LP29948-4
database_cross_reference: LNC:MTHU011970
database_cross_reference: MSH:D035002
database_cross_reference: MTH:U003308
database_cross_reference: NCI:C12742
database_cross_reference: NCI:C77625
database_cross_reference: NCI_CDISC:C12742
database_cross_reference: NCI_CDISC:C77625
database_cross_reference: NCI_NICHD:C12742
database_cross_reference: RCD:7NB1.
database_cross_reference: RCD:Xa1Z9
database_cross_reference: SNM:T-Y9000
database_cross_reference: SNM:U000524
database_cross_reference: SNMI:T-D9000
database_cross_reference: SNOMEDCT_US:61685007
database_cross_reference: SNOMEDCT_VET:116013008
database_cross_reference: SNOMEDCT_VET:61685007
database_cross_reference: UWDA:7184

Buttocks
type: Class
subclass of: Lower Extremity
PMOID: PMO:00000086
Subclass_of: Lower Extremity
Tree Number: T1.2.2.3.1

Foot
type: Class
subclass of: Lower Extremity
MCID: MC00005244
PMOID: PMO:00000087
Subclass_of: Lower Extremity
Synonym: FEET
Synonym: FOOT
Synonym: Feet
Synonym: Feet (Anatomy)
Synonym: Foot structure
Synonym: Foot structure (body structure)
Synonym: Foot, NOS
Synonym: Pedal
Synonym: Pes
Synonym: Terminal segment of free lower limb
Tree Number: T1.2.2.3.2
database_cross_reference: AOD:0000005175
database_cross_reference: CCPSS:1006709
database_cross_reference: CHV:0000005187
database_cross_reference: CSP:2715-5477
database_cross_reference: FMA:9664
database_cross_reference: LCH:U001850
database_cross_reference: LCH_NW:sh85050352
database_cross_reference: LNC:LP207497-1
database_cross_reference: LNC:LP221475-9
database_cross_reference: LNC:LP7245-6
database_cross_reference: LNC:MTHU002679
database_cross_reference: MSH:D005528
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32622
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C32622
database_cross_reference: NCI_NICHD:C32622
database_cross_reference: OMIM:MTHU000075
database_cross_reference: PSY:19500
database_cross_reference: RCD:Xa1fX
database_cross_reference: RCD:Xa8Sz
database_cross_reference: SNM:T-Y9700
database_cross_reference: SNMI:T-D9700
database_cross_reference: SNOMEDCT_US:56459004
database_cross_reference: UWDA:9664

Hip
type: Class
subclass of: Lower Extremity
MCID: MC00006270
PMOID: PMO:00000094
Subclass_of: Lower Extremity
Synonym: Bone structure of hip
Synonym: Bone structure of hip (body structure)
Synonym: Coxa
Synonym: Coxas
Synonym: D25 HIPS
Synonym: HIP
Synonym: HIPS
Synonym: Hip region
Synonym: Hip region structure
Synonym: Hip region structure (body structure)
Tree Number: T1.2.2.3.3
database_cross_reference: AOD:0000004701
database_cross_reference: CCPSS:1017313
database_cross_reference: CHV:0000006140
database_cross_reference: CSP:2715-4488
database_cross_reference: FMA:24964
database_cross_reference: LNC:LA3973-0
database_cross_reference: LNC:LP199979-8
database_cross_reference: LNC:LP207492-2
database_cross_reference: LNC:LP7348-8
database_cross_reference: LNC:MTHU002686
database_cross_reference: MSH:D006615
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C64193
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C64193
database_cross_reference: NCI_NICHD:C64193
database_cross_reference: PSY:23020
database_cross_reference: RCD:Xa1qf
database_cross_reference: RCD:Xa8Sx
database_cross_reference: RCD:XaABt
database_cross_reference: SNM:T-Y1500
database_cross_reference: SNMI:T-D2500
database_cross_reference: SNOMEDCT_US:24136001
database_cross_reference: SNOMEDCT_US:29836001
database_cross_reference: SNOMEDCT_US:304907005
database_cross_reference: UWDA:24964

Knee
type: Class
subclass of: Lower Extremity
MCID: MC00007278
PMOID: PMO:00000095
Subclass_of: Lower Extremity
Synonym: Bone structure of knee
Synonym: Bone structure of knee (body structure)
Synonym: Genu
Synonym: KNEE
Synonym: Knee, NOS
Synonym: genu
Synonym: knee
Synonym: knee s
Synonym: knee's
Synonym: knee(s)
Tree Number: T1.2.2.3.4
database_cross_reference: AOD:0000008182
database_cross_reference: CCPSS:1005647
database_cross_reference: CHV:0000007124
database_cross_reference: CHV:0000021456
database_cross_reference: CSP:2715-4875
database_cross_reference: FMA:24974
database_cross_reference: LCH:U002590
database_cross_reference: LCH_NW:sh85072671
database_cross_reference: LNC:LA22232-5
database_cross_reference: LNC:LP199984-8
database_cross_reference: LNC:LP207494-8
database_cross_reference: LNC:LP7381-9
database_cross_reference: LNC:MTHU002687
database_cross_reference: MSH:D007717
database_cross_reference: MTH:NOCODE
database_cross_reference: PSY:27440
database_cross_reference: SNM:T-Y9200
database_cross_reference: SNMI:T-D9200
database_cross_reference: SNOMEDCT_US:304679005
database_cross_reference: SNOMEDCT_VET:304679005
database_cross_reference: UWDA:24974

Leg
type: Class
subclass of: Lower Extremity
MCID: MC00007421
PMOID: PMO:00000096
Subclass_of: Lower Extremity
Synonym: D9 LOWER EXTREMITIES
Synonym: Extremities, Lower
Synonym: Extremity, Lower
Synonym: Extremity-lower
Synonym: HINDLIMB
Synonym: Hind Limb
Synonym: Hind limb
Synonym: Hindlimb
Synonym: Hindlimb, NOS
Synonym: Hindquarter
Tree Number: T1.2.2.3.5
database_cross_reference: AOD:0000027660
database_cross_reference: AOD:0000027661
database_cross_reference: CCPSS:1001127
database_cross_reference: CHV:0000007269
database_cross_reference: CST:BODY/LE
database_cross_reference: FMA:7184
database_cross_reference: LCH:U006432
database_cross_reference: LNC:LA18112-5
database_cross_reference: LNC:LP199985-5
database_cross_reference: LNC:LP207495-5
database_cross_reference: LNC:LP29948-4
database_cross_reference: LNC:MTHU011970
database_cross_reference: MSH:D035002
database_cross_reference: MTH:U003308
database_cross_reference: NCI:C12742
database_cross_reference: NCI:C77625
database_cross_reference: NCI_CDISC:C12742
database_cross_reference: NCI_CDISC:C77625
database_cross_reference: NCI_NICHD:C12742
database_cross_reference: RCD:7NB1.
database_cross_reference: RCD:Xa1Z9
database_cross_reference: SNM:T-Y9000
database_cross_reference: SNM:U000524
database_cross_reference: SNMI:T-D9000
database_cross_reference: SNOMEDCT_US:61685007
database_cross_reference: SNOMEDCT_VET:116013008
database_cross_reference: SNOMEDCT_VET:61685007
database_cross_reference: UWDA:7184

Thigh
type: Class
subclass of: Lower Extremity
MCID: MC00432489
PMOID: PMO:00000097
Subclass_of: Lower Extremity
Synonym: Entire thigh
Synonym: Entire thigh (body structure)
Tree Number: T1.2.2.3.6
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:302544002

Head
type: Class
subclass of: Body Regions
MCID: MC00058498
PMOID: PMO:00000098
Subclass_of: Body Regions
Synonym: Caput (caudatus)
Synonym: Caput nuclei caudati
Synonym: Caudate nuclear head
Synonym: HCd
Synonym: Head of caudate nucleus
Synonym: Structure of head of caudate nucleus
Synonym: Structure of head of caudate nucleus (body structure)
Synonym: head
Synonym: head of caudate nucleus
Synonym: head of the caudate nucleus
Tree Number: T1.2.3
database_cross_reference: FMA:61852
database_cross_reference: MTH:NOCODE
database_cross_reference: NEU:227
database_cross_reference: RCD:Xa12g
database_cross_reference: SNM:T-X3210
database_cross_reference: SNMI:T-A3210
database_cross_reference: SNOMEDCT_US:88017005

Ear
type: Class
subclass of: Head
MCID: MC00004261
PMOID: PMO:00000099
Subclass_of: Head
Synonym: Apparatus, Vestibulocochlear
Synonym: Auris
Synonym: EAR
Synonym: Ear (Anatomy)
Synonym: Ear and related structures
Synonym: Ear structure
Synonym: Ear structure (body structure)
Synonym: Ear-related structure
Synonym: Ears
Synonym: Organum vestibulocochleare
Tree Number: T1.2.3.1
database_cross_reference: AOD:0000004413
database_cross_reference: AOD:0000027965
database_cross_reference: CCPSS:0031468
database_cross_reference: CHV:0000004225
database_cross_reference: CHV:0000035664
database_cross_reference: CSP:0973-2108
database_cross_reference: FMA:52780
database_cross_reference: FMA:77739
database_cross_reference: LCH:U001490
database_cross_reference: LCH_NW:sh85040383
database_cross_reference: LNC:LA21929-7
database_cross_reference: LNC:LA22163-2
database_cross_reference: LNC:LP7188-8
database_cross_reference: LNC:MTHU001407
database_cross_reference: MSH:D004423
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12394
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12394
database_cross_reference: NCI_NICHD:C12394
database_cross_reference: OMIM:MTHU000052
database_cross_reference: PSY:15720
database_cross_reference: RCD:Xa05g
database_cross_reference: SNM:T-XY000
database_cross_reference: SNM:T-XY700
database_cross_reference: SNM:U000515
database_cross_reference: SNMI:T-AB000
database_cross_reference: SNOMEDCT_US:117590005
database_cross_reference: SNOMEDCT_VET:117590005
database_cross_reference: UWDA:52780
database_cross_reference: UWDA:77739

Face
type: Class
subclass of: Head
MCID: MC00432494
PMOID: PMO:00000100
Subclass_of: Head
Synonym: Entire face
Synonym: Entire face (body structure)
Tree Number: T1.2.3.2
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:302549007

Superficial Musculoaponeurotic System
type: Class
subclass of: Face
subclass of: Neck
PMOID: PMO:00000101
Subclass_of: Face
Subclass_of: Neck
Tree Number: T1.2.3.2.1
Tree Number: T1.2.4.1

Cheek
type: Class
subclass of: Face
MCID: MC00430667
PMOID: PMO:00000102
Subclass_of: Face
Synonym: Entire buccal region of face
Synonym: Entire cheek
Synonym: Entire cheek (body structure)
Tree Number: T1.2.3.2.2
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:182325008

Chin
type: Class
subclass of: Face
PMOID: PMO:00000103
Subclass_of: Face
Tree Number: T1.2.3.2.3

Eye
type: Class
subclass of: Face
MCID: MC00004894
PMOID: PMO:00000104
Subclass_of: Face
Synonym: ?Eye
Synonym: Bulbus oculi
Synonym: EYE
Synonym: Eye (Anatomy)
Synonym: Eye (body structure)
Synonym: Eye structure
Synonym: Eye structure (body structure)
Synonym: Eye, NOS
Synonym: Eyeball
Synonym: Eyeball structure
Tree Number: T1.2.3.2.4
database_cross_reference: AOD:0000002468
database_cross_reference: AOD:0000017567
database_cross_reference: CCPSS:0057369
database_cross_reference: CHV:0000004810
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1107-6922
database_cross_reference: FMA:12513
database_cross_reference: FMA:54448
database_cross_reference: LCH:U001714
database_cross_reference: LCH_NW:sh85046642
database_cross_reference: LNC:LA14722-5
database_cross_reference: LNC:LP117007-7
database_cross_reference: LNC:LP207778-4
database_cross_reference: LNC:LP7218-3
database_cross_reference: LNC:LP7222-5
database_cross_reference: LNC:LP7797-6
database_cross_reference: LNC:MTHU000064
database_cross_reference: LNC:MTHU001409
database_cross_reference: LNC:MTHU001430
database_cross_reference: LNC:MTHU038905
database_cross_reference: MSH:D005123
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U003284
database_cross_reference: NCI:C12401
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12401
database_cross_reference: NCI_NCI-GLOSS:CDR0000350235
database_cross_reference: NCI_NICHD:C12401
database_cross_reference: OMIM:MTHU000020
database_cross_reference: PSY:18890
database_cross_reference: RCD:X74in
database_cross_reference: RCD:Xa05O
database_cross_reference: RCD:Xa0Gs
database_cross_reference: RCD:Xa1S4
database_cross_reference: SNM:T-XX000
database_cross_reference: SNMI:T-AA000
database_cross_reference: SNOMEDCT_US:276432009
database_cross_reference: SNOMEDCT_US:367568005
database_cross_reference: SNOMEDCT_US:371398005
database_cross_reference: SNOMEDCT_US:81745001
database_cross_reference: SNOMEDCT_VET:81745001
database_cross_reference: UWDA:12513
database_cross_reference: UWDA:54448

Forehead
type: Class
subclass of: Face
PMOID: PMO:00000108
Subclass_of: Face
Tree Number: T1.2.3.2.5

Mouth
type: Class
subclass of: Face
PMOID: PMO:00000109
Subclass_of: Face
Tree Number: T1.2.3.2.6

Nose
type: Class
subclass of: Face
MCID: MC00009020
PMOID: PMO:00000111
Subclass_of: Face
Synonym: 21 NOSE
Synonym: JAMU Sexty
Synonym: Letomint
Synonym: NASAL
Synonym: NOSE
Synonym: Nasal
Synonym: Nasal (qualifier value)
Synonym: Nasal structure
Synonym: Nasal structure (body structure)
Synonym: Naso-
Tree Number: T1.2.3.2.7
database_cross_reference: AOD:0000017227
database_cross_reference: CHV:0000008786
database_cross_reference: CSP:1996-0769
database_cross_reference: DRUGBANK:DB00388
database_cross_reference: DRUGBANK:DB00588
database_cross_reference: DRUGBANK:DB00935
database_cross_reference: DRUGBANK:DB10672
database_cross_reference: FMA:46472
database_cross_reference: LCH:U003268
database_cross_reference: LCH_NW:sh85092748
database_cross_reference: LNC:LA22156-6
database_cross_reference: LNC:LP7443-7
database_cross_reference: MSH:D009666
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12756
database_cross_reference: NCI:C27958
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12756
database_cross_reference: NCI_CDISC:C27958
database_cross_reference: NCI_NCI-GLOSS:CDR0000044061
database_cross_reference: NCI_NICHD:C12756
database_cross_reference: NCI_NICHD:C27958
database_cross_reference: OMIM:MTHU000119
database_cross_reference: PSY:34510
database_cross_reference: RCD:7N20.
database_cross_reference: RCD:X810j
database_cross_reference: RCD:Xa06M
database_cross_reference: SNM:T-21000
database_cross_reference: SNM:U000428
database_cross_reference: SNMI:T-21000
database_cross_reference: SNOMEDCT_US:260540009
database_cross_reference: SNOMEDCT_US:45206002
database_cross_reference: UWDA:46472

Parotid Region
type: Class
subclass of: Face
PMOID: PMO:00000112
Subclass_of: Face
Tree Number: T1.2.3.2.8

Nasolabial Fold
type: Class
subclass of: Face
PMOID: PMO:00000113
Subclass_of: Face
Tree Number: T1.2.3.2.9

Scalp
type: Class
subclass of: Head
MCID: MC00011620
PMOID: PMO:00000114
Subclass_of: Head
Synonym: SCALP
Synonym: Scalp (Anatomy)
Synonym: Scalp structure
Synonym: Scalp structure (body structure)
Synonym: Scalp, NOS
Synonym: Scalps
Synonym: scalp
Synonym: scalp anatomy
Synonym: scalping
Synonym: scalps
Tree Number: T1.2.3.3
database_cross_reference: AOD:0000016960
database_cross_reference: CHV:0000011066
database_cross_reference: CSP:2716-1466
database_cross_reference: FMA:46494
database_cross_reference: LCH:U004219
database_cross_reference: LCH_NW:sh85117928
database_cross_reference: LNC:LA18815-3
database_cross_reference: LNC:LP30549-7
database_cross_reference: LNC:MTHU015066
database_cross_reference: MSH:D012535
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C89807
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C89807
database_cross_reference: NCI_NICHD:C89807
database_cross_reference: PSY:45370
database_cross_reference: RCD:7N710
database_cross_reference: SNM:T-Y0160
database_cross_reference: SNMI:T-D1160
database_cross_reference: SNOMEDCT_US:41695006
database_cross_reference: UWDA:46494

Skull Base
type: Class
subclass of: Head
PMOID: PMO:00000115
Subclass_of: Head
Tree Number: T1.2.3.4

Cranial Fossa, Posterior
type: Class
subclass of: Skull Base
PMOID: PMO:00000116
Subclass_of: Skull Base
Tree Number: T1.2.3.4.1

Cranial Fossa, Anterior
type: Class
subclass of: Skull Base
PMOID: PMO:00000117
Subclass_of: Skull Base
Tree Number: T1.2.3.4.2

Cranial Fossa, Middle
type: Class
subclass of: Skull Base
PMOID: PMO:00000118
Subclass_of: Skull Base
Tree Number: T1.2.3.4.3

Neck
type: Class
subclass of: Body Regions
MCID: MC00432495
PMOID: PMO:00000119
Subclass_of: Body Regions
Synonym: Entire neck
Synonym: Entire neck (body structure)
Tree Number: T1.2.4
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:302550007

Perineum
type: Class
subclass of: Body Regions
PMOID: PMO:00000120
Subclass_of: Body Regions
Tree Number: T1.2.5

Viscera
type: Class
subclass of: Body Regions
MCID: MC00013607
PMOID: PMO:00000121
Subclass_of: Body Regions
Synonym: Set of viscera
Synonym: Set of viscus organs
Synonym: Viscera set
Synonym: Viscera, NOS
Synonym: Viscus
Synonym: viscera
Synonym: viscus
Tree Number: T1.2.6
database_cross_reference: AOD:0000017019
database_cross_reference: CHV:0000013025
database_cross_reference: CSP:2935-4508
database_cross_reference: FMA:55564
database_cross_reference: FMA:7085
database_cross_reference: LCH:U004963
database_cross_reference: LCH_NW:sh85143850
database_cross_reference: MSH:D014781
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C28287
database_cross_reference: NCI_NCI-GLOSS:CDR0000044633
database_cross_reference: SNM:T-Y5000
database_cross_reference: SNMI:T-D4030
database_cross_reference: SNOMEDCT_US:19203006
database_cross_reference: UWDA:55564
database_cross_reference: UWDA:7085

Transplants
type: Class
subclass of: Body Regions
MCID: MC00115950
PMOID: PMO:00000122
Subclass_of: Body Regions
Synonym: 155 TRANSPLANTS
Synonym: GRAFT
Synonym: Graft
Synonym: Graft, NOS
Synonym: Grafts
Synonym: TRANSPLANTS
Synonym: Transplant
Synonym: Transplant (body structure)
Synonym: Transplant, NOS
Synonym: Transplanted organ
Tree Number: T1.2.7
database_cross_reference: CHV:0000029559
database_cross_reference: LNC:LP134079-5
database_cross_reference: LNC:MTHU041680
database_cross_reference: MSH:D019737
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12981
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C45416
database_cross_reference: NCI_FDA:290
database_cross_reference: NCI_FDA:C45416
database_cross_reference: NCI_NCI-GLOSS:CDR0000046373
database_cross_reference: NCI_NCPDP:C45416
database_cross_reference: SNMI:M-15500
database_cross_reference: SNOMEDCT_US:24486003

Allografts
type: Class
subclass of: Transplants
MCID: MC00150367
PMOID: PMO:00000123
Subclass_of: Transplants
Synonym: Allogeneic graft
Synonym: Allograft
Synonym: Allograft (substance)
Synonym: Allograft -RETIRED-
Synonym: Allograft surgical material
Synonym: Homograft
Synonym: Homografts
Synonym: Homologous Transplant
Synonym: Homologous Transplants
Synonym: Homologous graft
Tree Number: T1.2.7.1
database_cross_reference: CHV:0000035932
database_cross_reference: LCH_NW:sh85061768
database_cross_reference: MSH:D064591
database_cross_reference: MTH:U000914
database_cross_reference: NCI:C60701
database_cross_reference: RCD:X90J6
database_cross_reference: SNMI:G-D830
database_cross_reference: SNOMEDCT_US:123194006
database_cross_reference: SNOMEDCT_US:261221006
database_cross_reference: SNOMEDCT_US:7970006
database_cross_reference: UMD:17-165

Autografts
type: Class
subclass of: Transplants
MCID: MC00174005
PMOID: PMO:00000124
Subclass_of: Transplants
Synonym: Autochthonous graft
Synonym: Autochtonous graft
Synonym: Autogenous graft
Synonym: Autograft
Synonym: Autograft (substance)
Synonym: Autograft -RETIRED-
Synonym: Autograft Material
Synonym: Autologous Graft
Synonym: Autologous Transplant
Synonym: Autologous Transplants
Tree Number: T1.2.7.2
database_cross_reference: CHV:0000039572
database_cross_reference: CHV:0000045092
database_cross_reference: LCH_NW:sh85010065
database_cross_reference: MSH:D064592
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75339
database_cross_reference: RCD:Xa4fP
database_cross_reference: SNMI:G-D810
database_cross_reference: SNOMEDCT_US:123146007
database_cross_reference: SNOMEDCT_US:15879007

Heterografts
type: Class
subclass of: Transplants
MCID: MC00163750
PMOID: PMO:00000125
Subclass_of: Transplants
Synonym: Heterograft
Synonym: Heterologous graft
Synonym: Heteroplastic graft
Synonym: Xenograft
Synonym: Xenograft (substance)
Synonym: Xenograft -RETIRED-
Synonym: Xenograft type of graft
Synonym: Xenografts
Synonym: Xenotransplant
Synonym: Xenotransplantation
Tree Number: T1.2.7.3
database_cross_reference: CHV:0000038160
database_cross_reference: LCH_NW:sh85148789
database_cross_reference: MSH:D064593
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12932
database_cross_reference: NCI:GTEx
database_cross_reference: NCI_NCI-GLOSS:CDR0000044095
database_cross_reference: RCD:X90Jk
database_cross_reference: SNMI:G-D840
database_cross_reference: SNOMEDCT_US:123147003
database_cross_reference: SNOMEDCT_US:67650000

Bone-Patellar Tendon-Bone Grafts
type: Class
subclass of: Transplants
MCID: MC00943929
PMOID: PMO:00000126
Subclass_of: Transplants
Synonym: Bone Patellar Tendon Bone Grafts
Synonym: Bone-Patellar Tendon-Bone Graft
Tree Number: T1.2.7.4
database_cross_reference: MSH:D064594

Composite Tissue Allografts
type: Class
subclass of: Transplants
MCID: MC00943872
PMOID: PMO:00000127
Subclass_of: Transplants
Synonym: Composite Tissue Allograft
Synonym: Vascularized Composite Allograft
Synonym: Vascularized Composite Allografts
Tree Number: T1.2.7.5
database_cross_reference: MSH:D064595

Isografts
type: Class
subclass of: Transplants
MCID: MC00139448
PMOID: PMO:00000128
Subclass_of: Transplants
Synonym: Homograft, Isogeneic
Synonym: Homograft, Syngeneic
Synonym: Homografts, Isogeneic
Synonym: Homografts, Syngeneic
Synonym: Isogeneic Homograft
Synonym: Isogeneic Homografts
Synonym: Isogeneic graft
Synonym: Isogeneic graft (substance)
Synonym: Isogeneic graft -RETIRED-
Synonym: Isograft
Tree Number: T1.2.7.6
database_cross_reference: CSP:2935-6726
database_cross_reference: MSH:D064596
database_cross_reference: MTH:U000298
database_cross_reference: NCI:C122939
database_cross_reference: RCD:XaDw8
database_cross_reference: SNMI:G-D820
database_cross_reference: SNOMEDCT_US:123195007
database_cross_reference: SNOMEDCT_US:67194007

Organs at Risk
type: Class
subclass of: Body Regions
PMOID: PMO:00000129
Subclass_of: Body Regions
Tree Number: T1.2.8

Anatomic Landmarks
type: Class
subclass of: Body Regions
PMOID: PMO:00000130
Subclass_of: Body Regions
Tree Number: T1.2.9

Transplant Donor Site
type: Class
subclass of: Body Regions
PMOID: PMO:00000131
Subclass_of: Body Regions
Tree Number: T1.2.10

Torso
type: Class
subclass of: Body Regions
PMOID: PMO:00000132
Subclass_of: Body Regions
Tree Number: T1.2.11

Abdomen
type: Class
subclass of: Torso
MCID: MC00059478
PMOID: PMO:00000133
Subclass_of: Torso
Synonym: ABDOMEN CANCER
Synonym: Abdomen--Cancer
Synonym: Malig neo abdomen
Synonym: Malignant neoplasm of abdomen
Synonym: Malignant neoplasm of abdomen (disorder)
Synonym: Malignant tumor of abdomen
Synonym: Malignant tumor of abdomen (disorder)
Synonym: Malignant tumour of abdomen
Synonym: abdomen cancer
Synonym: abdomen neoplasm
Tree Number: T1.2.11.1
database_cross_reference: CCPSS:0034377
database_cross_reference: CHV:0000017367
database_cross_reference: CSP:2005-4146
database_cross_reference: DO:DOID:122
database_cross_reference: DO:DOID:284
database_cross_reference: ICD10:C76.2
database_cross_reference: ICD10AM:C76.2
database_cross_reference: ICD10CM:C76.2
database_cross_reference: ICD9CM:195.2
database_cross_reference: LCH_NW:sh85000095
database_cross_reference: MDR:10025692
database_cross_reference: MEDCIN:98324
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:B552.
database_cross_reference: RCDAE:B552.
database_cross_reference: SNOMEDCT_US:188366002

Groin
type: Class
subclass of: Abdomen
PMOID: PMO:00000134
Subclass_of: Abdomen
Tree Number: T1.2.11.1.1

Inguinal Canal
type: Class
subclass of: Abdomen
MCID: MC00431301
PMOID: PMO:00000135
Subclass_of: Abdomen
Synonym: Entire inguinal canal
Synonym: Entire inguinal canal (body structure)
Synonym: Inguinal canal
Tree Number: T1.2.11.1.2
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:243966008

Umbilicus
type: Class
subclass of: Abdomen
MCID: MC00431837
PMOID: PMO:00000136
Subclass_of: Abdomen
Synonym: Entire umbilicus
Synonym: Entire umbilicus (body structure)
Tree Number: T1.2.11.1.3
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:265800007

Abdominal Cavity
type: Class
subclass of: Abdomen
PMOID: PMO:00000137
Subclass_of: Abdomen
Tree Number: T1.2.11.1.4

Peritoneum
type: Class
subclass of: Serous Membrane
MCID: MC00009943
PMOID: PMO:00000138
Subclass_of: Serous Membrane
Synonym: D44-D46 PERITONEUM
Synonym: PERITONEUM
Synonym: Peritoneum (serous membrane) structure
Synonym: Peritoneum (serous membrane) structure (body structure)
Synonym: Peritoneum, NOS
Synonym: Serous membrane of abdomen
Synonym: Serous membrane of abdomen, NOS
Synonym: Wall of peritoneal sac
Synonym: peritoneum
Tree Number: T1.3.8.4.2
database_cross_reference: AOD:0000016978
database_cross_reference: CHV:0000009529
database_cross_reference: CSP:0461-6710
database_cross_reference: FMA:9584
database_cross_reference: LCH:U003570
database_cross_reference: LCH_NW:sh85099958
database_cross_reference: LNC:LA4689-1
database_cross_reference: LNC:LP30178-5
database_cross_reference: LNC:MTHU014433
database_cross_reference: MSH:D010537
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12770
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12770
database_cross_reference: NCI_NCI-GLOSS:CDR0000045829
database_cross_reference: NCI_NICHD:C12770
database_cross_reference: RCD:7N812
database_cross_reference: SNM:T-Y4400
database_cross_reference: SNMI:T-D4400
database_cross_reference: SNOMEDCT_US:15425007
database_cross_reference: UWDA:9584

Peritoneal Stomata
type: Class
subclass of: Tissues
PMOID: PMO:00000144
Subclass_of: Tissues
Tree Number: T1.3.13

Abdominal Wall
type: Class
subclass of: Abdomen
MCID: MC00292556
PMOID: PMO:00000146
Subclass_of: Abdomen
Synonym: ABDOMINAL WALL
Synonym: AW - Abdominal wall
Synonym: Abdomen>Abdominal wall
Synonym: Abdominal wall
Synonym: Abdominal wall proper
Synonym: Abdominal wall structure
Synonym: Abdominal wall structure (body structure)
Synonym: Abdominal wall, NOS
Synonym: Wall of abdomen
Synonym: Wall of abdomen proper
Tree Number: T1.2.11.1.5
database_cross_reference: AOD:0000027656
database_cross_reference: CHV:0000049454
database_cross_reference: FMA:10429
database_cross_reference: FMA:299989
database_cross_reference: LCH:U000004
database_cross_reference: LCH_NW:sh85000113
database_cross_reference: LNC:LP208113-3
database_cross_reference: LNC:LP208114-1
database_cross_reference: LNC:LP6993-2
database_cross_reference: LNC:MTHU003020
database_cross_reference: LNC:MTHU052056
database_cross_reference: MSH:D034861
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C77608
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C77608
database_cross_reference: NCI_NICHD:C77608
database_cross_reference: PSY:00020
database_cross_reference: RCD:7N81.
database_cross_reference: RCD:Xa1SY
database_cross_reference: SNM:T-Y4300
database_cross_reference: SNMI:T-D4300
database_cross_reference: SNOMEDCT_US:83908009
database_cross_reference: UWDA:10429

Back
type: Class
subclass of: Torso
PMOID: PMO:00000147
Subclass_of: Torso
Tree Number: T1.2.11.2

Lumbosacral Region
type: Class
subclass of: Back
PMOID: PMO:00000148
Subclass_of: Back
Tree Number: T1.2.11.2.1

Sacrococcygeal Region
type: Class
subclass of: Back
PMOID: PMO:00000149
Subclass_of: Back
Tree Number: T1.2.11.2.2

Pelvis
type: Class
subclass of: Torso
MCID: MC00009795
PMOID: PMO:00000150
Subclass_of: Torso
Synonym: BODY CAVITY, PELVIC
Synonym: D6 PELVIS
Synonym: PELVIC
Synonym: PELVIS
Synonym: Pelvic
Synonym: Pelvic (qualifier value)
Synonym: Pelvic Cavity
Synonym: Pelvic Region
Synonym: Pelvic region
Synonym: Pelvic structure
Tree Number: T1.2.11.3
database_cross_reference: AOD:0000016996
database_cross_reference: CCPSS:0024053
database_cross_reference: CCPSS:1009911
database_cross_reference: CHV:0000009406
database_cross_reference: CSP:0468-6889
database_cross_reference: CST:BODY/PELV
database_cross_reference: LCH_NW:sh85099317
database_cross_reference: LNC:LA16744-7
database_cross_reference: LNC:LA4690-9
database_cross_reference: LNC:LP199998-8
database_cross_reference: LNC:LP7467-6
database_cross_reference: LNC:MTHU001438
database_cross_reference: MEDLINEPLUS:287
database_cross_reference: MSH:D010388
database_cross_reference: MTH:U002149
database_cross_reference: NCI:C12767
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12767
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NCI-GLOSS:CDR0000045087
database_cross_reference: NCI_NCI-GLOSS:CDR0000046246
database_cross_reference: NCI_NICHD:C12767
database_cross_reference: OMIM:MTHU000037
database_cross_reference: RCD:Ub1cR
database_cross_reference: RCD:Xa0JM
database_cross_reference: RCD:Xa1gg
database_cross_reference: SNM:T-Y6000
database_cross_reference: SNM:U000521
database_cross_reference: SNMI:T-D6000
database_cross_reference: SNOMEDCT_US:12921003
database_cross_reference: SNOMEDCT_US:277113001

Pelvic Floor
type: Class
subclass of: Pelvis
MCID: MC00067351
PMOID: PMO:00000151
Subclass_of: Pelvis
Synonym: Diaphragm, Pelvic
Synonym: Diaphragma pelvis
Synonym: Diaphragms, Pelvic
Synonym: Floor, Pelvic
Synonym: Muscle of pelvic diaphragm
Synonym: Pelvic Diaphragm
Synonym: Pelvic Diaphragms
Synonym: Pelvic diaphragm
Synonym: Pelvic floor
Synonym: Pelvic floor structure
Tree Number: T1.2.11.3.1
database_cross_reference: CHV:0000020880
database_cross_reference: CSP:0468-6889
database_cross_reference: FMA:19726
database_cross_reference: LCH_NW:sh95007753
database_cross_reference: MSH:D017773
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X74x4
database_cross_reference: RCD:Xa1vL
database_cross_reference: SNM:T-Y6261
database_cross_reference: SNMI:T-14303
database_cross_reference: SNMI:T-D6236
database_cross_reference: SNOMEDCT_US:12461007
database_cross_reference: SNOMEDCT_US:87770006
database_cross_reference: UWDA:19726
database_cross_reference: UWDA:24229

Lesser Pelvis
type: Class
subclass of: Pelvis
MCID: MC00077284
PMOID: PMO:00000152
Subclass_of: Pelvis
Synonym: Lesser pelvis
Synonym: Minor pelvis
Synonym: Minor pelvis structure
Synonym: Minor pelvis structure (body structure)
Synonym: Minor, Pelvis
Synonym: Pelvis Minor
Synonym: Pelvis vera
Synonym: Pelvis, Lesser
Synonym: Pelvis, True
Synonym: Small pelvis
Tree Number: T1.2.11.3.2
database_cross_reference: CHV:0000022510
database_cross_reference: MSH:D057892
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-11383
database_cross_reference: SNM:T-Y6220
database_cross_reference: SNMI:T-D6220
database_cross_reference: SNOMEDCT_US:80266002
database_cross_reference: UWDA:75420

Thorax
type: Class
subclass of: Torso
MCID: MC00059477
PMOID: PMO:00000153
Subclass_of: Torso
Synonym: Malig neop thorax NOS
Synonym: Malign neopl thorax
Synonym: Malignant Neoplasm of Thorax
Synonym: Malignant Neoplasm of the Thorax
Synonym: Malignant Thoracic Neoplasm
Synonym: Malignant Thoracic Tumor
Synonym: Malignant Tumor of Thorax
Synonym: Malignant Tumor of the Thorax
Synonym: Malignant neoplasm of thorax
Synonym: Malignant neoplasm of thorax (disorder)
Tree Number: T1.2.11.4
database_cross_reference: CHV:0000051572
database_cross_reference: CSP:2005-5041
database_cross_reference: ICD10:C76.1
database_cross_reference: ICD10AM:C76.1
database_cross_reference: ICD10CM:C76.1
database_cross_reference: ICD9CM:195.1
database_cross_reference: MDR:10026532
database_cross_reference: MEDCIN:98323
database_cross_reference: MTH:U000736
database_cross_reference: NCI:C3576
database_cross_reference: RCD:B551.
database_cross_reference: RCD:B551z
database_cross_reference: RCDAE:B551.
database_cross_reference: SNOMEDCT_US:188361007
database_cross_reference: SNOMEDCT_US:188365003

Thoracic Cavity
type: Class
subclass of: Thorax
PMOID: PMO:00000154
Subclass_of: Thorax
Tree Number: T1.2.11.4.1

Thoracic Wall
type: Class
subclass of: Thorax
MCID: MC00067062
PMOID: PMO:00000157
Subclass_of: Thorax
Synonym: CHEST WALL
Synonym: Chest Wall
Synonym: Chest wall
Synonym: Chest wall structure
Synonym: Chest wall structure (body structure)
Synonym: Chest wall, NOS
Synonym: THORACIC WALL
Synonym: Thoracic wall
Synonym: Wall of thorax
Synonym: Wall, Chest
Tree Number: T1.2.11.4.2
database_cross_reference: AOD:0000016971
database_cross_reference: CHV:0000020287
database_cross_reference: FMA:10428
database_cross_reference: FMA:50060
database_cross_reference: LNC:LA4178-5
database_cross_reference: LNC:LP208118-2
database_cross_reference: LNC:LP7140-9
database_cross_reference: LNC:MTHU002672
database_cross_reference: MSH:D035441
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C62484
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C62484
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NCI-GLOSS:CDR0000044996
database_cross_reference: NCI_NICHD:C62484
database_cross_reference: RCD:7N80.
database_cross_reference: RCD:Xa1SZ
database_cross_reference: SNM:T-Y2150
database_cross_reference: SNMI:T-D3050
database_cross_reference: SNOMEDCT_US:78904004
database_cross_reference: UWDA:10428
database_cross_reference: UWDA:50060

Trigger Points
type: Class
subclass of: Body Regions
PMOID: PMO:00000158
Subclass_of: Body Regions
Tree Number: T1.2.12

Tissues
type: Class
subclass of: Anatomical Structure
MCID: MC00012886
PMOID: PMO:00000159
Subclass_of: Anatomical Structure
Synonym: Body Tissues
Synonym: Body tissue
Synonym: Body tissue structure
Synonym: Body tissue structure (body structure)
Synonym: Body tissue, NOS
Synonym: Normal Tissue
Synonym: Portion of tissue
Synonym: TISSUE
Synonym: Textus
Synonym: Tiss
Tree Number: T1.3
database_cross_reference: AOD:0000001777
database_cross_reference: CCPSS:0019045
database_cross_reference: CHV:0000012321
database_cross_reference: CSP:2935-3962
database_cross_reference: FMA:9637
database_cross_reference: LCH:U006631
database_cross_reference: LCH_NW:sh85135594
database_cross_reference: LNC:LP200029-9
database_cross_reference: LNC:LP200064-6
database_cross_reference: LNC:LP61649-7
database_cross_reference: LNC:LP7641-6
database_cross_reference: LNC:MTHU049889
database_cross_reference: MSH:D014024
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12801
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12801
database_cross_reference: NCI_NCI-GLOSS:CDR0000046683
database_cross_reference: PSY:53300
database_cross_reference: SNM:T-00050
database_cross_reference: SNMI:T-D0050
database_cross_reference: SNOMEDCT_US:85756007
database_cross_reference: UWDA:9637

Parenchymal Tissue
type: Class
subclass of: Tissues
MCID: MC01054884
PMOID: PMO:00000160
Subclass_of: Tissues
Synonym: Parenchymal Tissues
Synonym: Tissue, Parenchymal
Synonym: Tissues, Parenchymal
Tree Number: T1.3.1
database_cross_reference: MSH:D000072356

Margins of Excision
type: Class
subclass of: Tissues
MCID: MC00077217
PMOID: PMO:00000161
Subclass_of: Tissues
Synonym: Excision Margin
Synonym: Excision Margins
Synonym: Margin, Resection
Synonym: Margin, Surgical
Synonym: Margins of Excision [Disease/Finding]
Synonym: Margins of excision
Synonym: Margins, Resection
Synonym: Margins, Surgical
Synonym: Resection Margin
Synonym: Resection Margins
Tree Number: T1.3.2
database_cross_reference: CHV:0000022434
database_cross_reference: MSH:D000072662
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C41227
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044531
database_cross_reference: NDFRT:N0000192881
database_cross_reference: SNM:T-00100
database_cross_reference: SNMI:T-D0100
database_cross_reference: SNOMEDCT_US:82868003

Body Fluid Compartments
type: Class
subclass of: Tissues
PMOID: PMO:00000162
Subclass_of: Tissues
Tree Number: T1.3.3

Extracellular Space
type: Class
subclass of: Body Fluid Compartments
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000163
Subclass_of: Body Fluid Compartments
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Tree Number: T1.3.3.1
Tree Number: T1.4.5
Tree Number: T2.8.5

Intracellular Space
type: Class
subclass of: Body Fluid Compartments
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000164
Subclass_of: Body Fluid Compartments
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Tree Number: T1.3.3.2
Tree Number: T1.4.8
Tree Number: T2.8.8

Connective Tissue
type: Class
subclass of: Tissues
MCID: MC00003209
PMOID: PMO:00000165
Subclass_of: Tissues
Synonym: CONNECTIVE TISSUE
Synonym: Connective Tissues
Synonym: Connective tissue
Synonym: Connective tissue (substance)
Synonym: Connective tissue structure
Synonym: Connective tissue structure (body structure)
Synonym: Connective tissue, NOS
Synonym: Connective tissues
Synonym: Portion of connective tissue
Synonym: Textus connectivus
Tree Number: T1.3.4
database_cross_reference: AOD:0000016845
database_cross_reference: CHV:0000003293
database_cross_reference: CSP:0729-5335
database_cross_reference: FMA:9640
database_cross_reference: LCH:U001138
database_cross_reference: LCH_NW:sh85031183
database_cross_reference: MSH:D003238
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12374
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12374
database_cross_reference: NCI_NCI-GLOSS:CDR0000044013
database_cross_reference: NCI_NICHD:C12374
database_cross_reference: PSY:11330
database_cross_reference: RCD:7N8A3
database_cross_reference: SNM:T-1X200
database_cross_reference: SNMI:T-1A200
database_cross_reference: SNOMEDCT_US:181769001
database_cross_reference: SNOMEDCT_US:21793004
database_cross_reference: UWDA:9640

Adipose Tissue
type: Class
subclass of: Connective Tissue
MCID: MC00000394
PMOID: PMO:00000166
Subclass_of: Connective Tissue
Synonym: ADIPOSE TISSUE
Synonym: Adipocytus unigutturalis
Synonym: Adipose tissue
Synonym: Adipose tissue (body structure)
Synonym: Adipose tissues
Synonym: Body Fat
Synonym: Fat Tissue
Synonym: Fatty Tissue
Synonym: Fatty tissue
Synonym: Textus adiposus albus
Tree Number: T1.3.4.1
database_cross_reference: AOD:0000016854
database_cross_reference: AOD:0000027611
database_cross_reference: CHV:0000000740
database_cross_reference: CHV:0000021877
database_cross_reference: CSP:0729-5444
database_cross_reference: CSP:0729-5627
database_cross_reference: FMA:20110
database_cross_reference: LCH:U000075
database_cross_reference: LCH_NW:sh85000877
database_cross_reference: LNC:LP7226-6
database_cross_reference: MSH:D000273
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12472
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12472
database_cross_reference: NCI_CDISC:SDTM-SPECTYPE
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: RCD:XaBo1
database_cross_reference: SNM:T-1X010
database_cross_reference: SNM:T-1X020
database_cross_reference: SNMI:T-1A010
database_cross_reference: SNMI:T-1A020
database_cross_reference: SNOMEDCT_US:38888009
database_cross_reference: SNOMEDCT_US:55603005
database_cross_reference: UWDA:20110
database_cross_reference: UWDA:20117

Adipose Tissue, Beige
type: Class
subclass of: Adipose Tissue
MCID: MC01054877
PMOID: PMO:00000167
Subclass_of: Adipose Tissue
Synonym: Adipose Tissue, Brite
Synonym: Adipose Tissues, Beige
Synonym: Adipose Tissues, Brite
Synonym: Beige Adipose Tissue
Synonym: Beige Adipose Tissues
Synonym: Beige Brite Adipose Tissue
Synonym: Beige Brite Fat
Synonym: Beige Brite Fats
Synonym: Beige Fat
Synonym: Brite Adipose Tissue
Tree Number: T1.3.4.1.1
database_cross_reference: MSH:D000069796

Adipose Tissue, Brown
type: Class
subclass of: Adipose Tissue
MCID: MC00001989
PMOID: PMO:00000168
Subclass_of: Adipose Tissue
Synonym: ADIPOSE TISSUE, BROWN
Synonym: Adipocytus multigutturalis
Synonym: BAT
Synonym: Bat
Synonym: Brown Adipose Tissue
Synonym: Brown Fat
Synonym: Brown adipose tissue
Synonym: Brown fat
Synonym: Brown fat (body structure)
Synonym: Fat, Brown
Tree Number: T1.3.4.1.2
database_cross_reference: AOD:0000016856
database_cross_reference: CHV:0000002198
database_cross_reference: CSP:0729-5553
database_cross_reference: DRUGBANK:DB13897
database_cross_reference: DRUGBANK:DB13898
database_cross_reference: DRUGBANK:DB13899
database_cross_reference: DRUGBANK:DB13900
database_cross_reference: DRUGBANK:DB13901
database_cross_reference: DRUGBANK:DB13902
database_cross_reference: DRUGBANK:DB13903
database_cross_reference: FMA:20118
database_cross_reference: LCH_NW:sh85017245
database_cross_reference: MSH:D002001
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32235
database_cross_reference: NCI_CDISC:C32235
database_cross_reference: SNM:T-1X040
database_cross_reference: SNMI:T-1A040
database_cross_reference: SNOMEDCT_US:15965003
database_cross_reference: UWDA:20118

Adipose Tissue, White
type: Class
subclass of: Adipose Tissue
MCID: MC00577175
PMOID: PMO:00000169
Subclass_of: Adipose Tissue
Synonym: ADIPOSE TISSUE, WHITE
Synonym: Adipocytus unigutturalis
Synonym: Fat, White
Synonym: Textus adiposus albus
Synonym: Tissue, White Adipose
Synonym: Unilocular adipose tissue
Synonym: White Adipose Tissue
Synonym: White Fat
Synonym: White adipose tissue
Synonym: White fat
Tree Number: T1.3.4.1.3
database_cross_reference: CHV:0000021877
database_cross_reference: CSP:0729-5444
database_cross_reference: FMA:20117
database_cross_reference: MSH:D052436
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33889
database_cross_reference: NCI_CDISC:C33889
database_cross_reference: UWDA:20117

Bone and Bones
type: Class
subclass of: Connective Tissue
MCID: MC00001858
PMOID: PMO:00000174
Subclass_of: Connective Tissue
Synonym: BONE BONES
Synonym: BONES BONE
Synonym: Bones and Bone
Synonym: Bones and Bone Tissue
Synonym: bone and bones
Synonym: bone bone
Tree Number: T1.3.4.2
database_cross_reference: CHV:0000002059
database_cross_reference: MSH:D001842

Bone-Implant Interface
type: Class
subclass of: Bone and Bones
PMOID: PMO:00000175
Subclass_of: Bone and Bones
Tree Number: T1.3.4.2.1

Cortical Bone
type: Class
subclass of: Bone and Bones
MCID: MC00071627
PMOID: PMO:00000176
Subclass_of: Bone and Bones
Synonym: Bone Cortex
Synonym: Compact Bone
Synonym: Compact Bone Tissue
Synonym: Compact Bones
Synonym: Compact bone
Synonym: Compact bone (tissue)
Synonym: Compact bone structure
Synonym: Compact bone structure (body structure)
Synonym: Compact bone tissue
Synonym: Cortex of Bone
Tree Number: T1.3.4.2.2
database_cross_reference: AOD:0000016873
database_cross_reference: AOD:0000027620
database_cross_reference: AOD:0000027623
database_cross_reference: AOD:0000027624
database_cross_reference: CHV:0000021607
database_cross_reference: FMA:24018
database_cross_reference: MSH:D000071538
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C52714
database_cross_reference: SNM:T-1X542
database_cross_reference: SNMI:T-11031
database_cross_reference: SNOMEDCT_US:32217005
database_cross_reference: UWDA:24018
database_cross_reference: UWDA:66766

Cancellous Bone
type: Class
subclass of: Bone and Bones
MCID: MC00071626
PMOID: PMO:00000178
Subclass_of: Bone and Bones
Synonym: Bone, Cancellous
Synonym: Bone, Spongy
Synonym: Bone, Trabecular
Synonym: Bones, Cancellous
Synonym: Bones, Spongy
Synonym: Bones, Trabecular
Synonym: Cancellous Bones
Synonym: Cancellous bone
Synonym: Cancellous bone (substance)
Synonym: Spongy Bone
Tree Number: T1.3.4.2.3
database_cross_reference: AOD:0000016875
database_cross_reference: AOD:0000027626
database_cross_reference: AOD:0000027628
database_cross_reference: AOD:0000027630
database_cross_reference: AOD:0000027632
database_cross_reference: CHV:0000021606
database_cross_reference: CSP:4007-0118
database_cross_reference: FMA:24019
database_cross_reference: FMA:85273
database_cross_reference: MSH:D000071556
database_cross_reference: RCD:X90Dy
database_cross_reference: SNM:T-1X540
database_cross_reference: SNM:T-1X541
database_cross_reference: SNMI:T-11030
database_cross_reference: SNOMEDCT_US:20870005
database_cross_reference: SNOMEDCT_US:261229008
database_cross_reference: UWDA:24019
database_cross_reference: UWDA:66767

Bone Matrix
type: Class
subclass of: Bone and Bones
MCID: MC00001872
PMOID: PMO:00000179
Subclass_of: Bone and Bones
Synonym: Bone Matrices
Synonym: Bone matrix
Synonym: Bone matrix (substance)
Synonym: Matrices, Bone
Synonym: Matrix, Bone
Synonym: bone matrix
Tree Number: T1.3.4.2.4
database_cross_reference: AOD:0000016878
database_cross_reference: CHV:0000002078
database_cross_reference: FMA:66830
database_cross_reference: MSH:D001857
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32222
database_cross_reference: SNMI:T-11034
database_cross_reference: SNOMEDCT_US:45001002

Bony Callus
type: Class
subclass of: Bone and Bones
MCID: MC00002151
PMOID: PMO:00000180
Subclass_of: Bone and Bones
Synonym: Bone callus
Synonym: Bony callus
Synonym: Bony callus (morphologic abnormality)
Synonym: CALLUS
Synonym: Callus
Synonym: Callus of bone
Synonym: Callus of bone (finding)
Synonym: Callus, Bony
Synonym: bone callus
Synonym: bony callus
Tree Number: T1.3.4.2.5
database_cross_reference: CHV:0000002318
database_cross_reference: COSTAR:132
database_cross_reference: MSH:D002146
database_cross_reference: MTH:U001777
database_cross_reference: SNM:M-49920
database_cross_reference: SNMI:M-78870
database_cross_reference: SNOMEDCT_US:27881006
database_cross_reference: SNOMEDCT_US:443092002

Periosteum
type: Class
subclass of: Bone and Bones
MCID: MC00009928
PMOID: PMO:00000181
Subclass_of: Bone and Bones
Synonym: Periosteum (body structure)
Synonym: periosteum
Tree Number: T1.3.4.2.6
database_cross_reference: AOD:0000016889
database_cross_reference: CHV:0000009513
database_cross_reference: CSP:2715-3800
database_cross_reference: FMA:24041
database_cross_reference: LCH:U003564
database_cross_reference: LCH_NW:sh85099929
database_cross_reference: MSH:D010521
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13184
database_cross_reference: SNM:T-1X510
database_cross_reference: SNMI:T-11020
database_cross_reference: SNOMEDCT_US:33840008
database_cross_reference: UWDA:24041

Cartilage
type: Class
subclass of: Connective Tissue
MCID: MC00002355
PMOID: PMO:00000182
Subclass_of: Connective Tissue
Synonym: 1A7 CARTILAGINOUS TISSUES
Synonym: CARTILAGE
Synonym: CARTILAGINOUS TISSUES
Synonym: Cartilage (tissue)
Synonym: Cartilage tissue
Synonym: Cartilage tissue (body structure)
Synonym: Cartilage, NOS
Synonym: Cartilagenous
Synonym: Cartilages
Synonym: Cartilages set
Tree Number: T1.3.4.3
database_cross_reference: AOD:0000016859
database_cross_reference: CHV:0000002496
database_cross_reference: CHV:0000057131
database_cross_reference: CSP:2715-4273
database_cross_reference: FMA:37377
database_cross_reference: FMA:71500
database_cross_reference: LCH:U000824
database_cross_reference: LCH_NW:sh85020509
database_cross_reference: MSH:D002356
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12373
database_cross_reference: NCI:C32268
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C32268
database_cross_reference: NCI_NCI-GLOSS:CDR0000044190
database_cross_reference: NDDF:005578
database_cross_reference: RCD:X79Xk
database_cross_reference: SNM:T-1X700
database_cross_reference: SNM:U000425
database_cross_reference: SNMI:T-1A700
database_cross_reference: SNOMEDCT_US:309312004
database_cross_reference: SNOMEDCT_US:61496007
database_cross_reference: UWDA:37377
database_cross_reference: UWDA:71500

Fibrocartilage
type: Class
subclass of: Cartilage
MCID: MC00224398
PMOID: PMO:00000183
Subclass_of: Cartilage
Synonym: Fibrocartilage (body structure)
Synonym: Fibrocartilage, NOS
Synonym: fibrocartilage
Synonym: fibrous cartilage
Tree Number: T1.3.4.3.1
database_cross_reference: AOD:0000016867
database_cross_reference: AOD:0000027614
database_cross_reference: CHV:0000043931
database_cross_reference: FMA:64784
database_cross_reference: MSH:D051445
database_cross_reference: NCI:C32599
database_cross_reference: SNMI:T-1A715
database_cross_reference: SNOMEDCT_US:91685003
database_cross_reference: UWDA:64784

Hyaline Cartilage
type: Class
subclass of: Cartilage
MCID: MC00073670
PMOID: PMO:00000192
Subclass_of: Cartilage
Synonym: Cartilage, Hyaline
Synonym: Cartilages, Hyaline
Synonym: Hyaline Cartilages
Synonym: Hyaline cartilage
Synonym: Hyaline cartilage (body structure)
Synonym: hyaline cartilage
Tree Number: T1.3.4.3.2
database_cross_reference: AOD:0000016861
database_cross_reference: CHV:0000021901
database_cross_reference: FMA:64783
database_cross_reference: MSH:D051457
database_cross_reference: NCI:C32746
database_cross_reference: SNM:T-1X710
database_cross_reference: SNMI:T-1A710
database_cross_reference: SNOMEDCT_US:39298000
database_cross_reference: UWDA:64783

Elastic Cartilage
type: Class
subclass of: Cartilage
MCID: MC00223832
PMOID: PMO:00000193
Subclass_of: Cartilage
Synonym: Cartilage, Elastic
Synonym: Cartilages, Elastic
Synonym: Elastic Cartilages
Synonym: Elastic cartilage
Synonym: elastic cartilage
Synonym: reticular cartilage
Synonym: yellow cartilage
Tree Number: T1.3.4.3.3
database_cross_reference: AOD:0000016868
database_cross_reference: AOD:0000027615
database_cross_reference: AOD:0000027616
database_cross_reference: CHV:0000043640
database_cross_reference: FMA:64785
database_cross_reference: MSH:D051472
database_cross_reference: NCI:C32494
database_cross_reference: UWDA:64785

Elastic Tissue
type: Class
subclass of: Connective Tissue
MCID: MC00004340
PMOID: PMO:00000194
Subclass_of: Connective Tissue
Synonym: Elastic Tissues
Synonym: Elastic connective tissue
Synonym: Elastic tissue
Synonym: Elastic tissue (body structure)
Synonym: Elastic tissue, NOS
Synonym: Textus connectivus elasticus
Synonym: Tissue, Elastic
Synonym: Tissues, Elastic
Synonym: elastic tissue
Tree Number: T1.3.4.4
database_cross_reference: CHV:0000004312
database_cross_reference: CSP:0729-5662
database_cross_reference: FMA:20113
database_cross_reference: LCH:U001517
database_cross_reference: LCH_NW:sh85041513
database_cross_reference: MSH:D004547
database_cross_reference: SNM:T-1X240
database_cross_reference: SNMI:T-1A240
database_cross_reference: SNOMEDCT_US:27197004
database_cross_reference: UWDA:20113

Fascia
type: Class
subclass of: Connective Tissue
MCID: MC00004966
PMOID: PMO:00000195
Subclass_of: Connective Tissue
Synonym: 186-189 FASCIAS/APONEUROSES
Synonym: FASCIA
Synonym: FASCIAS/APONEUROSES
Synonym: Fascia (body structure)
Synonym: Fascia (cluster)
Synonym: Fascia (organ)
Synonym: Fascia cluster
Synonym: Fascia organ
Synonym: Fascia organ component
Synonym: Fascia, NOS
Tree Number: T1.3.4.5
database_cross_reference: AOD:0000016919
database_cross_reference: CHV:0000004898
database_cross_reference: CSP:0729-5335
database_cross_reference: FMA:20185
database_cross_reference: FMA:30318
database_cross_reference: FMA:321912
database_cross_reference: FMA:5023
database_cross_reference: MSH:D005205
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13108
database_cross_reference: NCI_CDISC:C13108
database_cross_reference: NCI_NICHD:C13108
database_cross_reference: RCD:7N8B.
database_cross_reference: RCD:X909X
database_cross_reference: RCD:XaAqD
database_cross_reference: SNM:T-18600
database_cross_reference: SNM:U000422
database_cross_reference: SNMI:T-18600
database_cross_reference: SNOMEDCT_US:181766008
database_cross_reference: SNOMEDCT_US:261078007
database_cross_reference: SNOMEDCT_US:84820005
database_cross_reference: UWDA:20185
database_cross_reference: UWDA:30318
database_cross_reference: UWDA:5023

Fascia Lata
type: Class
subclass of: Fascia
MCID: MC00004967
PMOID: PMO:00000196
Subclass_of: Fascia
Synonym: Fascia Latas
Synonym: Fascia lata
Synonym: Fascia lata structure
Synonym: Fascia lata structure (body structure)
Synonym: Lata, Fascia
Synonym: Latas, Fascia
Synonym: fascia lata
Tree Number: T1.3.4.5.1
database_cross_reference: CHV:0000004899
database_cross_reference: FMA:13902
database_cross_reference: MSH:D005206
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32585
database_cross_reference: SNM:T-18910
database_cross_reference: SNMI:T-18910
database_cross_reference: SNOMEDCT_US:85695001
database_cross_reference: UWDA:13902

Tenon Capsule
type: Class
subclass of: Fascia
MCID: MC00724949
PMOID: PMO:00000197
Subclass_of: Fascia
Synonym: Capsule of Tenon
Synonym: Capsule, Tenon
Synonym: Capsule, Tenon's
Synonym: Eyeball, sheath
Synonym: Fascia bulbi
Synonym: Fascial sheath of eyeball
Synonym: Sheath of eyeball
Synonym: Structure of fascial sheath of eyeball
Synonym: Structure of fascial sheath of eyeball (body structure)
Synonym: Substantia Propria
Tree Number: T1.3.4.5.2
database_cross_reference: CHV:0000036863
database_cross_reference: FMA:58734
database_cross_reference: MSH:D058475
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33652
database_cross_reference: RCD:Xa1ST
database_cross_reference: RCD:Xa1TF
database_cross_reference: SNM:T-XX009
database_cross_reference: SNM:T-XX801
database_cross_reference: SNMI:T-AA009
database_cross_reference: SNOMEDCT_US:77011004

Granulation Tissue
type: Class
subclass of: Connective Tissue
MCID: MC00005832
PMOID: PMO:00000198
Subclass_of: Connective Tissue
Synonym: Granulation Tissues
Synonym: Granulation of tissue
Synonym: Granulation of tissue (finding)
Synonym: Granulation tissue
Synonym: Granulation tissue (morphologic abnormality)
Synonym: Granulation tissue, NOS
Synonym: Tissue granulation
Synonym: Tissue, Granulation
Synonym: Tissues, Granulation
Synonym: granulation of tissue
Tree Number: T1.3.4.6
database_cross_reference: AOD:0000001778
database_cross_reference: CHV:0000005682
database_cross_reference: CHV:0000044130
database_cross_reference: LCH:U002034
database_cross_reference: LCH_NW:sh85056439
database_cross_reference: MDR:10018675
database_cross_reference: MSH:D006097
database_cross_reference: NCI:C34652
database_cross_reference: RCD:Ua1bK
database_cross_reference: SNM:M-45020
database_cross_reference: SNMI:M-45020
database_cross_reference: SNOMEDCT_US:225541009
database_cross_reference: SNOMEDCT_US:61363009

Cicatrix
type: Class
subclass of: Granulation Tissue
MCID: MC00651743
PMOID: PMO:00000199
Subclass_of: Granulation Tissue
Synonym: Cicatrices
Synonym: Cicatrix [Disease/Finding]
Synonym: Fibrous scar
Synonym: Healing scar
Synonym: Healing scar (morphologic abnormality)
Synonym: SCAR
Synonym: Scar
Synonym: Scar (disorder)
Synonym: Scar (morphologic abnormality)
Synonym: Scar NOS
Tree Number: T1.3.4.6.1
database_cross_reference: CCPSS:0037723
database_cross_reference: COSTAR:U000604
database_cross_reference: CSP:1583-6215
database_cross_reference: ICD10CM:L90.5
database_cross_reference: ICPC2P:S99020
database_cross_reference: LCH:U001021
database_cross_reference: LCH_NW:sh85025918
database_cross_reference: LNC:LA24887-4
database_cross_reference: MDR:10039580
database_cross_reference: MDR:10039589
database_cross_reference: MEDCIN:34402
database_cross_reference: MEDCIN:6138
database_cross_reference: MEDLINEPLUS:3195
database_cross_reference: MSH:D002921
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:709.2
database_cross_reference: NCI:C34483
database_cross_reference: NCI_CDISC:C34483
database_cross_reference: NCI_FDA:2061
database_cross_reference: NCI_NICHD:C34483
database_cross_reference: NDFRT:N0000000790
database_cross_reference: OMIM:MTHU010020
database_cross_reference: RCD:XE1BX
database_cross_reference: RCD:XM1NO
database_cross_reference: SNM:M-49060
database_cross_reference: SNMI:M-78060
database_cross_reference: SNOMEDCT_US:123121007
database_cross_reference: SNOMEDCT_US:12402003
database_cross_reference: SNOMEDCT_US:156442008
database_cross_reference: SNOMEDCT_US:156443003
database_cross_reference: SNOMEDCT_US:201312003
database_cross_reference: SNOMEDCT_US:255450007
database_cross_reference: SNOMEDCT_US:267822001
database_cross_reference: SNOMEDCT_US:267872004
database_cross_reference: SNOMEDCT_US:275322007
database_cross_reference: SNOMEDCT_US:48677004

Ligaments
type: Class
subclass of: Connective Tissue
MCID: MC00007567
PMOID: PMO:00000203
Subclass_of: Connective Tissue
Synonym: 180-185 LIGAMENTS
Synonym: LIGAMENT
Synonym: LIGAMENTS
Synonym: Ligament
Synonym: Ligament (body structure)
Synonym: Ligament, NOS
Synonym: Ligamenta
Synonym: Ligaments set
Synonym: Set of ligaments
Synonym: Structure of ligament
Tree Number: T1.3.4.7
database_cross_reference: CHV:0000007416
database_cross_reference: CSP:2715-5176
database_cross_reference: FMA:30319
database_cross_reference: FMA:70773
database_cross_reference: LCH:U002692
database_cross_reference: LCH_NW:sh85076865
database_cross_reference: MSH:D008022
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13046
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13046
database_cross_reference: NCI_NICHD:C13046
database_cross_reference: SNM:T-18010
database_cross_reference: SNM:U000421
database_cross_reference: SNMI:T-18000
database_cross_reference: SNMI:T-18010
database_cross_reference: SNOMEDCT_US:256660002
database_cross_reference: SNOMEDCT_US:52082005
database_cross_reference: UWDA:30319
database_cross_reference: UWDA:70773

Round Ligaments
type: Class
subclass of: Ligaments
MCID: MC00011500
PMOID: PMO:00000204
Subclass_of: Ligaments
Synonym: Hunter's ligament
Synonym: Ligamentum Teres Uteri
Synonym: Ligamentum Teres Uterus
Synonym: Ligamentum teres uteri
Synonym: Round Ligament of Uterus
Synonym: Round Ligament of the Uterus
Synonym: Round ligament
Synonym: Round ligament of uterus
Synonym: Structure of round ligament of uterus
Synonym: Structure of round ligament of uterus (body structure)
Tree Number: T1.3.4.7.1
database_cross_reference: CHV:0000010955
database_cross_reference: FMA:20420
database_cross_reference: MSH:D012404
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34009
database_cross_reference: RCD:X756q
database_cross_reference: SNM:T-86700
database_cross_reference: SNMI:T-D6507
database_cross_reference: SNOMEDCT_US:50840003
database_cross_reference: UWDA:20420

Broad Ligament
type: Class
subclass of: Ligaments
MCID: MC00001946
PMOID: PMO:00000208
Subclass_of: Ligaments
Synonym: Broad Ligaments
Synonym: Broad ligament
Synonym: Broad ligament of uterus
Synonym: Broad ligament structure
Synonym: Broad ligament structure (body structure)
Synonym: Broad ligament, NOS
Synonym: Broad uterine ligament
Synonym: Lateral Ligament
Synonym: Ligament, Broad
Synonym: Ligaments, Broad
Tree Number: T1.3.4.7.2
database_cross_reference: CHV:0000002166
database_cross_reference: FMA:16516
database_cross_reference: MSH:D001956
database_cross_reference: MTH:U001765
database_cross_reference: NCI:C12318
database_cross_reference: NCI:TCGA
database_cross_reference: SNM:T-86300
database_cross_reference: SNMI:T-D6500
database_cross_reference: SNOMEDCT_US:34411009
database_cross_reference: UWDA:16516

Ligaments, Articular
type: Class
subclass of: Ligaments
MCID: MC00007568
PMOID: PMO:00000209
Subclass_of: Ligaments
Synonym: Articular Ligament
Synonym: Articular Ligaments
Synonym: Articular ligaments
Synonym: Ligament
Synonym: Ligament of joint
Synonym: Ligament of joint (body structure)
Synonym: Ligament of joint, unspec
Synonym: Ligament of joint, unspecified
Synonym: Ligament of joint, unspecified (body structure)
Synonym: Ligament, Articular
Tree Number: T1.3.4.7.3
database_cross_reference: AOD:0000017066
database_cross_reference: CHV:0000007417
database_cross_reference: CSP:2715-5219
database_cross_reference: MSH:D008023
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:7NAK1
database_cross_reference: RCD:7NC..
database_cross_reference: RCDSY:7NAK1
database_cross_reference: RCDSY:7NC..
database_cross_reference: SNOMEDCT_US:123859001
database_cross_reference: SNOMEDCT_US:182237007

Subcutaneous Tissue
type: Class
subclass of: Connective Tissue
MCID: MC00071317
PMOID: PMO:00000219
Subclass_of: Connective Tissue
Synonym: Adipose Tissue, Subcutaneous
Synonym: Fat, Subcutaneous
Synonym: Fats, Subcutaneous
Synonym: Fatty layer of subcutaneous tissue
Synonym: Fatty layer of superficial fascia
Synonym: Paniculus adiposus
Synonym: Panniculus adiposus
Synonym: Panniculus adiposus (Tela subcutanea)
Synonym: Panniculus adiposus telae subcutaneae
Synonym: SUBCUTIS
Tree Number: T1.3.4.8
database_cross_reference: CHV:0000021586
database_cross_reference: FMA:74315
database_cross_reference: MSH:D050151
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33645
database_cross_reference: NCI_CDISC:C33645
database_cross_reference: NCI_NICHD:C33645
database_cross_reference: SNM:T-1X030
database_cross_reference: SNMI:T-03020
database_cross_reference: SNOMEDCT_US:67769002
database_cross_reference: UWDA:74315
database_cross_reference: UWDA:78251

Wharton Jelly
type: Class
subclass of: Connective Tissue
MCID: MC00077764
PMOID: PMO:00000220
Subclass_of: Connective Tissue
Synonym: Jelly, Wharton
Synonym: Jelly, Wharton's
Synonym: Structure of Wharton jelly
Synonym: Structure of Wharton's jelly
Synonym: Structure of Wharton's jelly (body structure)
Synonym: Umbilical mucous connective tissue
Synonym: Wharton's Jelly
Synonym: Wharton's jelly
Synonym: Whartons Jelly
Synonym: wharton's jelly
Tree Number: T1.3.4.9
database_cross_reference: CHV:0000022584
database_cross_reference: MSH:D059631
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34213
database_cross_reference: SNM:T-88830
database_cross_reference: SNMI:T-F1830
database_cross_reference: SNOMEDCT_US:53455001

Adventitia
type: Class
subclass of: Connective Tissue
MCID: MC00073655
PMOID: PMO:00000221
Subclass_of: Connective Tissue
Synonym: Adventitia, Tunica
Synonym: Tunica Adventitia
Synonym: Tunica Externa
Synonym: Tunica adventitia
Synonym: Tunica adventitia (body structure)
Synonym: Tunica adventitia, NOS
Synonym: Tunica externa
Synonym: adventitia
Synonym: tunica adventitia
Tree Number: T1.3.4.10
database_cross_reference: AOD:0000016914
database_cross_reference: AOD:0000027647
database_cross_reference: CHV:0000021891
database_cross_reference: FMA:45635
database_cross_reference: MSH:D063194
database_cross_reference: NCI:C33818
database_cross_reference: SNMI:T-1A190
database_cross_reference: SNOMEDCT_US:30180000
database_cross_reference: UWDA:45635
database_cross_reference: UWDA:76726

Epithelium
type: Class
subclass of: Tissues
MCID: MC00004628
PMOID: PMO:00000222
Subclass_of: Tissues
Synonym: Epithelial Tissue
Synonym: Epithelial Tissues
Synonym: Epithelial tissue
Synonym: Epithelial tissue, NOS
Synonym: Epithelium (body structure)
Synonym: Epithelium, NOS
Synonym: Portion of epithelium
Synonym: Textus epithelialis
Synonym: Tissue, Epithelial
Synonym: Tissues, Epithelial
Tree Number: T1.3.5
database_cross_reference: AOD:0000016922
database_cross_reference: AOD:0000027649
database_cross_reference: CHV:0000004580
database_cross_reference: CSP:2935-4235
database_cross_reference: FMA:9639
database_cross_reference: LCH:U001633
database_cross_reference: LCH_NW:sh85044466
database_cross_reference: LNC:LP34857-0
database_cross_reference: MSH:D004848
database_cross_reference: NCI:C12710
database_cross_reference: NCI:C45714
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046423
database_cross_reference: PSY:17730
database_cross_reference: SNM:T-00250
database_cross_reference: SNMI:T-00250
database_cross_reference: SNOMEDCT_US:31610004
database_cross_reference: UWDA:9639

Basement Membrane
type: Class
subclass of: Epithelium
subclass of: Membranes
MCID: MC00001513
PMOID: PMO:00000223
Subclass_of: Epithelium
Subclass_of: Membranes
Synonym: Basement Membranes
Synonym: Basement membrane
Synonym: Basement membrane (body structure)
Synonym: Basement membrane of connective tissue
Synonym: Basement membrane, NOS
Synonym: Membrana basalis
Synonym: Membrane, Basement
Synonym: Membranes, Basement
Synonym: basement membrane
Synonym: basement membranes
Tree Number: T1.3.5.1
Tree Number: T1.3.8.1
database_cross_reference: CHV:0000001722
database_cross_reference: CSP:1831-6535
database_cross_reference: FMA:63872
database_cross_reference: GO:GO:0005604
database_cross_reference: LCH_NW:sh85083467
database_cross_reference: LNC:LP14903-6
database_cross_reference: MSH:D001485
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13191
database_cross_reference: SNM:T-01210
database_cross_reference: SNMI:T-1A160
database_cross_reference: SNOMEDCT_US:123226008
database_cross_reference: SNOMEDCT_US:68989006
database_cross_reference: UWDA:63872

Bruch Membrane
type: Class
subclass of: Basement Membrane
MCID: MC00043176
PMOID: PMO:00000224
Subclass_of: Basement Membrane
Synonym: Basal lamina of choroid
Synonym: Bruch's Membrane
Synonym: Bruch's basal membrane
Synonym: Bruch's membrane
Synonym: Bruchs Membrane
Synonym: Lamina Basalis Choroideae
Synonym: Lamina basalis (Choroid)
Synonym: Lamina choroideae basalis
Synonym: Membrane, Bruch
Synonym: Membrane, Bruch's
Tree Number: T1.3.5.1.1
Tree Number: T1.3.8.1.3
database_cross_reference: FMA:58438
database_cross_reference: MSH:D016570
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-XX350
database_cross_reference: SNMI:T-AA350
database_cross_reference: SNOMEDCT_US:23127007
database_cross_reference: UWDA:58438

Endothelium
type: Class
subclass of: Epithelium
MCID: MC00004516
PMOID: PMO:00000225
Subclass_of: Epithelium
Synonym: Endothelial
Synonym: Endothelial tissue
Synonym: Endothelial tissue, NOS
Synonym: Endothelium (body structure)
Synonym: Endothelium, NOS
Synonym: Endotheliums
Synonym: endothelial tissue
Synonym: endothelium
Tree Number: T1.3.5.2
database_cross_reference: AOD:0000016935
database_cross_reference: CHV:0000004476
database_cross_reference: FMA:63916
database_cross_reference: LCH:U001591
database_cross_reference: LCH_NW:sh85043102
database_cross_reference: MSH:D004727
database_cross_reference: NCI:C12481
database_cross_reference: NCI:TCGA
database_cross_reference: SNM:T-1X160
database_cross_reference: SNMI:T-1A130
database_cross_reference: SNOMEDCT_US:27168002
database_cross_reference: UWDA:63916

Endothelium, Corneal
type: Class
subclass of: Endothelium
MCID: MC00004518
PMOID: PMO:00000226
Subclass_of: Endothelium
Synonym: Corneal Endothelium
Synonym: Corneal endothelium
Synonym: Endothelium of cornea
Synonym: Structure of corneal endothelium
Synonym: Structure of corneal endothelium (body structure)
Synonym: corneal endothelium
Tree Number: T1.3.5.2.1
database_cross_reference: CHV:0000004477
database_cross_reference: CSP:1109-4715
database_cross_reference: FMA:312267
database_cross_reference: MSH:D004728
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12707
database_cross_reference: SNOMEDCT_US:65431007
database_cross_reference: UWDA:63882

Endothelium, Lymphatic
type: Class
subclass of: Endothelium
MCID: MC00004519
PMOID: PMO:00000227
Subclass_of: Endothelium
Synonym: Endotheliums, Lymphatic
Synonym: Lymphatic Endothelium
Synonym: Lymphatic Endotheliums
Tree Number: T1.3.5.2.2
database_cross_reference: MSH:D004729

Endothelium, Vascular
type: Class
subclass of: Endothelium
MCID: MC00004520
PMOID: PMO:00000228
Subclass_of: Endothelium
Synonym: Endotheliums, Vascular
Synonym: Vascular Endothelium
Synonym: Vascular Endotheliums
Synonym: Vascular endothelium
Synonym: vascular endothelium
Tree Number: T1.3.5.2.3
database_cross_reference: CSP:0581-5523
database_cross_reference: LCH_NW:sh88005427
database_cross_reference: MSH:D004730
database_cross_reference: NCI:C13053

Epidermis
type: Class
subclass of: Epithelium
MCID: MC00004589
PMOID: PMO:00000229
Subclass_of: Epithelium
Synonym: EPIDERMAL TISSUE
Synonym: Entire portion of epidermis
Synonym: Epidermal
Synonym: Epidermis structure
Synonym: Epidermis structure (body structure)
Synonym: epidermis
Tree Number: T1.3.5.3
database_cross_reference: AOD:0000017124
database_cross_reference: CHV:0000004546
database_cross_reference: CSP:2716-0373
database_cross_reference: FMA:70596
database_cross_reference: LCH:U001626
database_cross_reference: LCH_NW:sh85044375
database_cross_reference: LNC:LP14303-9
database_cross_reference: MSH:D004817
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12708
database_cross_reference: NCI_CDISC:C12708
database_cross_reference: NCI_NCI-GLOSS:CDR0000046418
database_cross_reference: SNM:T-01100
database_cross_reference: SNMI:T-01100
database_cross_reference: SNOMEDCT_US:55988001
database_cross_reference: UWDA:70596

Hair Follicle
type: Class
subclass of: Epidermis
MCID: MC00070991
PMOID: PMO:00000230
Subclass_of: Epidermis
Synonym: Follicle, Hair
Synonym: Follicles
Synonym: Follicles, Hair
Synonym: Folliculus pili
Synonym: HAIR FOLLICLE
Synonym: Hair Follicles
Synonym: Hair follicle
Synonym: Hair follicle structure
Synonym: Hair follicle structure (body structure)
Synonym: Hair follicles
Tree Number: T1.3.5.3.1
database_cross_reference: AOD:0000017163
database_cross_reference: CHV:0000021522
database_cross_reference: CSP:2716-0997
database_cross_reference: FMA:70660
database_cross_reference: LCH_NW:sh85058320
database_cross_reference: MSH:D018859
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13317
database_cross_reference: NCI_CDISC:C13317
database_cross_reference: NCI_NCI-GLOSS:CDR0000046379
database_cross_reference: NCI_NICHD:C13317
database_cross_reference: RCD:Xa1Xu
database_cross_reference: SNM:T-01414
database_cross_reference: SNMI:T-01414
database_cross_reference: SNOMEDCT_US:67290009
database_cross_reference: UWDA:70660

Pigment Epithelium of Eye
type: Class
subclass of: Epithelium
MCID: MC00010212
PMOID: PMO:00000231
Subclass_of: Epithelium
Synonym: Eye Pigment Epithelium
Tree Number: T1.3.5.4
database_cross_reference: MSH:D010857

Seminiferous Epithelium
type: Class
subclass of: Epithelium
MCID: MC00011731
PMOID: PMO:00000232
Subclass_of: Epithelium
Synonym: Epithelium, Seminiferous
Synonym: Epitheliums, Seminiferous
Synonym: Seminiferous Epitheliums
Synonym: Spermatogenic epithelium
Synonym: Structure of spermatogenic epithelium
Synonym: Structure of spermatogenic epithelium (body structure)
Tree Number: T1.3.5.5
database_cross_reference: MSH:D012670
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C49296
database_cross_reference: SNM:T-78120
database_cross_reference: SNMI:T-94120
database_cross_reference: SNOMEDCT_US:53472008

Urothelium
type: Class
subclass of: Epithelium
MCID: MC00075358
PMOID: PMO:00000233
Subclass_of: Epithelium
Synonym: Epithelium, Urinary Tract
Synonym: Transitional Epithelium of the Urinary Tract
Synonym: Urinary Tract Epithelium
Synonym: Urinary tract transitional epithelium
Synonym: Uroepithelium
Synonym: Urothelium (body structure)
Synonym: Urothelium, NOS
Synonym: urothelium
Tree Number: T1.3.5.6
database_cross_reference: CSP:3045-6697
database_cross_reference: FMA:67695
database_cross_reference: MSH:D019459
database_cross_reference: NCI:C12884
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044975
database_cross_reference: SNM:T-70130
database_cross_reference: SNMI:T-70030
database_cross_reference: SNOMEDCT_US:57789003
database_cross_reference: UWDA:67695

Epithelium, Corneal
type: Class
subclass of: Epithelium
MCID: MC00152062
PMOID: PMO:00000234
Subclass_of: Epithelium
Synonym: Anterior Corneal Epithelium
Synonym: Anterior corneal epithelium
Synonym: Cornea, external epithelium
Synonym: Corneal Epithelium
Synonym: Corneal Epithelium, Anterior
Synonym: Corneal epithelium
Synonym: Epithelium anterius (Cornea)
Synonym: Epithelium anterius corneae
Synonym: Epithelium of cornea
Synonym: Epithelium, Anterior Corneal
Tree Number: T1.3.5.7
database_cross_reference: CHV:0000036892
database_cross_reference: CSP:1109-5183
database_cross_reference: FMA:58263
database_cross_reference: MSH:D019573
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12928
database_cross_reference: SNM:T-XX220
database_cross_reference: SNMI:T-AA220
database_cross_reference: SNOMEDCT_US:15775008
database_cross_reference: UWDA:58263

Exocrine Glands
type: Class
subclass of: Tissues
MCID: MC00004859
PMOID: PMO:00000235
Subclass_of: Tissues
Synonym: Apocrine
Synonym: Apocrine Gland
Synonym: Ducted gland
Synonym: Exocrine Gland
Synonym: Exocrine gland
Synonym: Exocrine gland structure
Synonym: Exocrine gland structure (body structure)
Synonym: Exocrine glands
Synonym: Gland, Exocrine
Synonym: Glands, Exocrine
Tree Number: T1.3.6
database_cross_reference: AOD:0000016940
database_cross_reference: CHV:0000004770
database_cross_reference: CSP:2935-4372
database_cross_reference: FMA:9596
database_cross_reference: LCH:U001704
database_cross_reference: LCH_NW:sh85046385
database_cross_reference: MSH:D005088
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12712
database_cross_reference: NCI_NCI-GLOSS:CDR0000335062
database_cross_reference: SNOMEDCT_US:362938003
database_cross_reference: UWDA:9596

Bartholin's Glands
type: Class
subclass of: Exocrine Glands
MCID: MC00001502
PMOID: PMO:00000236
Subclass_of: Exocrine Glands
Synonym: BARTHOLIN GLAND
Synonym: Bartholin Gland
Synonym: Bartholin Glands
Synonym: Bartholin gland
Synonym: Bartholin gland structure
Synonym: Bartholin's Gland
Synonym: Bartholin's gland
Synonym: Bartholin's gland structure
Synonym: Bartholin's gland structure (body structure)
Synonym: Bartholins Glands
Tree Number: T1.3.6.1
database_cross_reference: AOD:0000017422
database_cross_reference: CCPSS:0061348
database_cross_reference: CHV:0000001710
database_cross_reference: FMA:9598
database_cross_reference: LCH:U000502
database_cross_reference: LCH_NW:sh85011986
database_cross_reference: MSH:D001472
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12675
database_cross_reference: SNM:T-80500
database_cross_reference: SNMI:T-81510
database_cross_reference: SNOMEDCT_US:181443008
database_cross_reference: SNOMEDCT_US:87176006
database_cross_reference: UWDA:9598

Bulbourethral Glands
type: Class
subclass of: Exocrine Glands
MCID: MC00002007
PMOID: PMO:00000237
Subclass_of: Exocrine Glands
Synonym: Bulbo-urethral gland
Synonym: Bulbourethral Gland
Synonym: Bulbourethral gland
Synonym: Bulbourethral gland structure
Synonym: Bulbourethral gland structure (body structure)
Synonym: Cowper Gland
Synonym: Cowper Glands
Synonym: Cowper gland
Synonym: Cowper's Gland
Synonym: Cowper's Glands
Tree Number: T1.3.6.2
database_cross_reference: AOD:0000017431
database_cross_reference: AOD:0000017433
database_cross_reference: CHV:0000002215
database_cross_reference: FMA:9599
database_cross_reference: LCH_NW:sh85033663
database_cross_reference: MSH:D002030
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32395
database_cross_reference: NCI_CDISC:C32395
database_cross_reference: RCD:Xa0tm
database_cross_reference: RCD:Xa188
database_cross_reference: SNM:T-75170
database_cross_reference: SNMI:T-75170
database_cross_reference: SNOMEDCT_US:66997005
database_cross_reference: UWDA:9599

Lacrimal Apparatus
type: Class
subclass of: Exocrine Glands
MCID: MC00007319
PMOID: PMO:00000238
Subclass_of: Exocrine Glands
Synonym: Apparatus lacrimalis
Synonym: Apparatus, Lacrimal
Synonym: Lacrimal apparatus
Synonym: Lacrimal apparatus structure
Synonym: Lacrimal apparatus structure (body structure)
Synonym: Lacrimal system
Synonym: lacrimal apparatus
Synonym: lacrimal system
Tree Number: T1.3.6.3
database_cross_reference: CHV:0000007174
database_cross_reference: CSP:1110-5953
database_cross_reference: FMA:55605
database_cross_reference: LCH_NW:sh85073848
database_cross_reference: LNC:LP30525-7
database_cross_reference: LNC:MTHU015047
database_cross_reference: MSH:D007765
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32905
database_cross_reference: RCD:7N136
database_cross_reference: SNM:T-XX900
database_cross_reference: SNMI:T-AA900
database_cross_reference: SNOMEDCT_US:27760002
database_cross_reference: UWDA:55605

Mammary Glands, Animal
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000239
Subclass_of: Exocrine Glands
Tree Number: T1.3.6.4

Prostate
type: Class
subclass of: Exocrine Glands
MCID: MC00010757
PMOID: PMO:00000240
Subclass_of: Exocrine Glands
Synonym: 92 PROSTATE
Synonym: Genital System, Male, Prostate
Synonym: PROSTATE
Synonym: PROSTATE GLAND
Synonym: PROSTATIC
Synonym: Prostata
Synonym: Prostata (Glandula prostatica)
Synonym: Prostate Gland
Synonym: Prostate gland
Synonym: Prostate, NOS
Tree Number: T1.3.6.5
database_cross_reference: AOD:0000017436
database_cross_reference: CCPSS:0022563
database_cross_reference: CCPSS:0023098
database_cross_reference: CHV:0000010223
database_cross_reference: CSP:2587-5599
database_cross_reference: FMA:9600
database_cross_reference: LCH:U006564
database_cross_reference: LCH_NW:sh85107605
database_cross_reference: LNC:LP200001-8
database_cross_reference: LNC:LP7501-2
database_cross_reference: LNC:MTHU004957
database_cross_reference: MSH:D011467
database_cross_reference: MTH:U002195
database_cross_reference: NCI:C12410
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12410
database_cross_reference: NCI_NCI-GLOSS:CDR0000046539
database_cross_reference: NCI_NICHD:C12410
database_cross_reference: PSY:41140
database_cross_reference: RCD:7N511
database_cross_reference: RCD:XC0B1
database_cross_reference: RCD:XM0Q4
database_cross_reference: SNM:T-77100
database_cross_reference: SNMI:T-92000
database_cross_reference: SNOMEDCT_US:263847000
database_cross_reference: SNOMEDCT_US:279689003
database_cross_reference: SNOMEDCT_US:41216001
database_cross_reference: SNOMEDCT_VET:279689003
database_cross_reference: UWDA:9600

Salivary Glands
type: Class
subclass of: Exocrine Glands
MCID: MC00011564
PMOID: PMO:00000241
Subclass_of: Exocrine Glands
Synonym: 5-20 DISEASES OF THE SALIVARY GLANDS
Synonym: DISEASES OF THE SALIVARY GLANDS
Synonym: Disease of salivary gland
Synonym: Disease of salivary gland (disorder)
Synonym: Disease of salivary gland, NOS
Synonym: Disease of salivary gland, unspecified
Synonym: Disease of salivary glands
Synonym: Disease, Salivary Gland
Synonym: Diseases of salivary glands
Synonym: Diseases of the salivary glands
Tree Number: T1.3.6.6
database_cross_reference: CCPSS:0037756
database_cross_reference: CHV:0000011008
database_cross_reference: CSP:2139-2285
database_cross_reference: CST:DIG/SAL
database_cross_reference: HPO:HP:0010286
database_cross_reference: ICD10:K11
database_cross_reference: ICD10:K11.9
database_cross_reference: ICD10AM:K11
database_cross_reference: ICD10AM:K11.9
database_cross_reference: ICD10CM:K11
database_cross_reference: ICD10CM:K11.9
database_cross_reference: ICD9CM:527
database_cross_reference: ICD9CM:527.9
database_cross_reference: LCH_NW:sh85116808
database_cross_reference: MDR:10013136
database_cross_reference: MDR:10039405
database_cross_reference: MDR:10045759
database_cross_reference: MDR:10061935
database_cross_reference: MEDCIN:210394
database_cross_reference: MEDLINEPLUS:388
database_cross_reference: MSH:D012466
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26879
database_cross_reference: NDFRT:N0000002662
database_cross_reference: RCD:J07..
database_cross_reference: RCD:J07z.
database_cross_reference: SNM:D-6120
database_cross_reference: SNMI:D5-20000
database_cross_reference: SNOMEDCT_US:10890000
database_cross_reference: SNOMEDCT_US:155654009
database_cross_reference: SNOMEDCT_US:155658007
database_cross_reference: SNOMEDCT_US:196526006

Parotid Gland
type: Class
subclass of: Salivary Glands
MCID: MC00009753
PMOID: PMO:00000242
Subclass_of: Salivary Glands
Synonym: 611 PAROTID GLANDS
Synonym: GLAND, SALIVARY, PAROTID
Synonym: Gland, Parotid
Synonym: Glands, Parotid
Synonym: Glandula parotidea
Synonym: Neck>Parotid gland
Synonym: PAROTID GLAND
Synonym: PAROTID GLANDS
Synonym: Parotid
Synonym: Parotid Glands
Tree Number: T1.3.6.6.1
database_cross_reference: AOD:0000017249
database_cross_reference: CHV:0000009324
database_cross_reference: CSP:2139-1813
database_cross_reference: FMA:59790
database_cross_reference: LCH:U003489
database_cross_reference: LCH_NW:sh85098268
database_cross_reference: LNC:LA4653-7
database_cross_reference: LNC:LP207335-3
database_cross_reference: LNC:LP33682-3
database_cross_reference: LNC:MTHU051972
database_cross_reference: MSH:D010306
database_cross_reference: MTH:U002146
database_cross_reference: NCI:C12427
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12427
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C12427
database_cross_reference: RCD:7N240
database_cross_reference: SNM:T-55100
database_cross_reference: SNM:U000463
database_cross_reference: SNMI:T-61100
database_cross_reference: SNOMEDCT_US:45289007
database_cross_reference: UWDA:59790

Salivary Glands, Minor
type: Class
subclass of: Salivary Glands
MCID: MC00011568
PMOID: PMO:00000243
Subclass_of: Salivary Glands
Synonym: 614 MINOR SALIVARY GLANDS
Synonym: Gland, Minor Salivary
Synonym: Glands, Minor Salivary
Synonym: Glandulae salivariae minores
Synonym: MINOR SALIVARY GLANDS
Synonym: Minor Salivary Gland
Synonym: Minor Salivary Glands
Synonym: Minor salivary gland
Synonym: Minor salivary gland structure
Synonym: Minor salivary gland structure (body structure)
Tree Number: T1.3.6.6.2
database_cross_reference: CHV:0000011012
database_cross_reference: FMA:59789
database_cross_reference: FMA:71612
database_cross_reference: MSH:D012470
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33129
database_cross_reference: SNM:T-55400
database_cross_reference: SNM:U000465
database_cross_reference: SNMI:T-61400
database_cross_reference: SNOMEDCT_US:87626005
database_cross_reference: UWDA:59789
database_cross_reference: UWDA:71612

Sublingual Gland
type: Class
subclass of: Salivary Glands
MCID: MC00012312
PMOID: PMO:00000244
Subclass_of: Salivary Glands
Synonym: 612 SUBLINGUAL GLANDS
Synonym: Ductus sublingualis
Synonym: GLAND, SALIVARY, SUBLINGUAL
Synonym: Gland, Sublingual
Synonym: Glands, Sublingual
Synonym: Glandula sublingualis
Synonym: Rivinus' gland
Synonym: SUBLINGUAL GLANDS
Synonym: Sublingual Glands
Synonym: Sublingual Salivary Gland
Tree Number: T1.3.6.6.3
database_cross_reference: AOD:0000017250
database_cross_reference: CHV:0000011814
database_cross_reference: CSP:2139-1872
database_cross_reference: FMA:59791
database_cross_reference: LCH:U004515
database_cross_reference: LCH_NW:sh85129479
database_cross_reference: MSH:D013361
database_cross_reference: MTH:U002271
database_cross_reference: NCI:C12234
database_cross_reference: NCI_CDISC:C12234
database_cross_reference: SNM:T-55200
database_cross_reference: SNM:U000464
database_cross_reference: SNMI:T-61200
database_cross_reference: SNOMEDCT_US:88481005
database_cross_reference: UWDA:59791

Submandibular Gland
type: Class
subclass of: Salivary Glands
MCID: MC00012314
PMOID: PMO:00000245
Subclass_of: Salivary Glands
Synonym: 613 SUBMAXILLARY GLANDS
Synonym: GLAND, SALIVARY, SUBMANDIBULAR
Synonym: Gland, Salivary, Mandibular
Synonym: Gland, Submandibular
Synonym: Gland, Submaxillary
Synonym: Glands, Submandibular
Synonym: Glands, Submaxillary
Synonym: Glandula submandibularis
Synonym: SMG - Submandibular gland
Synonym: SUBMAXILLARY GLANDS
Tree Number: T1.3.6.6.4
database_cross_reference: AOD:0000017252
database_cross_reference: CHV:0000011815
database_cross_reference: CSP:2139-1931
database_cross_reference: FMA:55093
database_cross_reference: LCH:U004516
database_cross_reference: LCH_NW:sh85129482
database_cross_reference: LNC:LP34302-7
database_cross_reference: LNC:MTHU017267
database_cross_reference: MSH:D013363
database_cross_reference: MTH:U002272
database_cross_reference: NCI:C12233
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12233
database_cross_reference: RCD:7N241
database_cross_reference: RCD:Xa3XV
database_cross_reference: SNM:NOCODE
database_cross_reference: SNM:T-55300
database_cross_reference: SNMI:T-61300
database_cross_reference: SNOMEDCT_US:385296007
database_cross_reference: SNOMEDCT_US:54019009
database_cross_reference: UWDA:55093

Salivary Ducts
type: Class
subclass of: Salivary Glands
MCID: MC00099006
PMOID: PMO:00000246
Subclass_of: Salivary Glands
Synonym: Duct of salivary gland
Synonym: Duct, Salivary
Synonym: Ducts, Salivary
Synonym: Salivary Duct
Synonym: Salivary duct
Synonym: Salivary duct structure
Synonym: Salivary duct structure (body structure)
Synonym: Salivary duct, NOS
Synonym: Salivary gland duct
Synonym: Salivary gland duct, NOS
Tree Number: T1.3.6.6.5
database_cross_reference: CHV:0000027656
database_cross_reference: FMA:59908
database_cross_reference: MSH:D018987
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:7N245
database_cross_reference: RCD:XaCxG
database_cross_reference: SNM:T-55080
database_cross_reference: SNMI:T-61080
database_cross_reference: SNOMEDCT_US:181232003
database_cross_reference: SNOMEDCT_US:86961006
database_cross_reference: UWDA:59908

von Ebner Glands
type: Class
subclass of: Salivary Glands
MCID: MC00628830
PMOID: PMO:00000247
Subclass_of: Salivary Glands
Synonym: Ebner Glands, von
Synonym: Gland of von Ebner
Synonym: Gland, von Ebner's
Synonym: Glands, von Ebner
Synonym: Glands, von Ebner's
Synonym: Posterior lingual gland
Synonym: von Ebner Gland
Synonym: von Ebner's Gland
Synonym: von Ebner's Glands
Synonym: von Ebners Gland
Tree Number: T1.3.6.6.6
database_cross_reference: FMA:293448
database_cross_reference: MSH:D054838

Sebaceous Glands
type: Class
subclass of: Exocrine Glands
MCID: MC00011690
PMOID: PMO:00000248
Subclass_of: Exocrine Glands
Synonym: GLAND, SEBACEOUS
Synonym: Gland, Sebaceous
Synonym: Glands of Zeis
Synonym: Glands, Sebaceous
Synonym: Glandula sebacea
Synonym: Glandulae sebaceae
Synonym: SEBACEOUS GLAND
Synonym: Sebaceous Gland
Synonym: Sebaceous gland
Synonym: Sebaceous gland structure
Tree Number: T1.3.6.7
database_cross_reference: AOD:0000017148
database_cross_reference: CHV:0000011147
database_cross_reference: CSP:2716-1621
database_cross_reference: FMA:59160
database_cross_reference: FMA:71874
database_cross_reference: LCH:U004250
database_cross_reference: LCH_NW:sh85119389
database_cross_reference: MSH:D012627
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33519
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C33519
database_cross_reference: SNM:T-01310
database_cross_reference: SNMI:T-01310
database_cross_reference: SNOMEDCT_US:1028005
database_cross_reference: UWDA:59160
database_cross_reference: UWDA:71874

Meibomian Glands
type: Class
subclass of: Sebaceous Glands
MCID: MC00007986
PMOID: PMO:00000249
Subclass_of: Sebaceous Glands
Synonym: GLAND, MEIBOMIAN
Synonym: Gland of Meibom
Synonym: Gland, Meibomian
Synonym: Gland, Tarsal
Synonym: Glands, Meibomian
Synonym: Glands, Tarsal
Synonym: Glandulae tarsales
Synonym: Meibomian Gland
Synonym: Meibomian gland
Synonym: Meibomian glands
Tree Number: T1.3.6.7.1
database_cross_reference: CHV:0000007887
database_cross_reference: FMA:59104
database_cross_reference: FMA:71872
database_cross_reference: LCH:U002884
database_cross_reference: LCH_NW:sh85083334
database_cross_reference: MSH:D008537
database_cross_reference: MTH:474
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33075
database_cross_reference: NCI_CDISC:C33075
database_cross_reference: RCD:Xa1TO
database_cross_reference: SNM:T-XX850
database_cross_reference: SNMI:T-AA850
database_cross_reference: SNOMEDCT_US:1110006
database_cross_reference: UWDA:59104
database_cross_reference: UWDA:71872

Sweat Glands
type: Class
subclass of: Exocrine Glands
MCID: MC00012467
PMOID: PMO:00000250
Subclass_of: Exocrine Glands
Synonym: Gland, Sweat
Synonym: Glands, Sweat
Synonym: Glandula sudorifera
Synonym: SUDORIFEROUS GLAND
Synonym: Sudoriferous Gland
Synonym: Sudoriferous gland
Synonym: Sudoriferous gland, NOS
Synonym: Sweat Gland
Synonym: Sweat gland
Synonym: Sweat gland structure
Tree Number: T1.3.6.8
database_cross_reference: AOD:0000017142
database_cross_reference: AOD:0000027708
database_cross_reference: CHV:0000011951
database_cross_reference: CSP:2716-1933
database_cross_reference: FMA:59152
database_cross_reference: LCH:U004547
database_cross_reference: LCH_NW:sh85131026
database_cross_reference: MSH:D013545
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33712
database_cross_reference: NCI_CDISC:C33712
database_cross_reference: NCI_NICHD:C33712
database_cross_reference: SNMI:T-01380
database_cross_reference: SNOMEDCT_US:10410005
database_cross_reference: UWDA:59152

Apocrine Glands
type: Class
subclass of: Sweat Glands
MCID: MC00001161
PMOID: PMO:00000251
Subclass_of: Sweat Glands
Synonym: Apocrine Gland
Synonym: Apocrine gland
Synonym: Apocrine gland structure
Synonym: Apocrine gland structure (body structure)
Synonym: Apocrine gland, NOS
Synonym: Apocrine glands
Synonym: Gland, Apocrine
Synonym: Glands, Apocrine
Synonym: apocrine gland
Synonym: apocrine glands
Tree Number: T1.3.6.8.1
database_cross_reference: CHV:0000001379
database_cross_reference: LCH:U000330
database_cross_reference: LCH_NW:sh85006004
database_cross_reference: MSH:D001050
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-01320
database_cross_reference: SNMI:T-01320
database_cross_reference: SNOMEDCT_US:2789006

Eccrine Glands
type: Class
subclass of: Sweat Glands
MCID: MC00004278
PMOID: PMO:00000252
Subclass_of: Sweat Glands
Synonym: Eccrine Gland
Synonym: Eccrine Sweat Gland
Synonym: Eccrine gland
Synonym: Eccrine gland structure
Synonym: Eccrine gland structure (body structure)
Synonym: Eccrine gland, NOS
Synonym: Eccrine sweat gland
Synonym: Gland, Eccrine
Synonym: Glands, Eccrine
Synonym: eccrine gland
Tree Number: T1.3.6.8.2
database_cross_reference: CHV:0000004241
database_cross_reference: FMA:59154
database_cross_reference: MSH:D004439
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32490
database_cross_reference: NCI_NCI-GLOSS:CDR0000393531
database_cross_reference: SNM:T-01330
database_cross_reference: SNMI:T-01330
database_cross_reference: SNOMEDCT_US:2759004
database_cross_reference: UWDA:59154

Pancreas, Exocrine
type: Class
subclass of: Exocrine Glands
MCID: MC00173369
PMOID: PMO:00000253
Subclass_of: Exocrine Glands
Synonym: Exocrine Pancreas
Synonym: Exocrine pancreas
Synonym: Exocrine pancreas, NOS
Synonym: PANCREAS, EXOCRINE
Synonym: Pars exocrina pancreatis
Synonym: Structure of exocrine pancreas
Synonym: Structure of exocrine pancreas (body structure)
Synonym: exocrine pancreas
Tree Number: T1.3.6.10
database_cross_reference: AOD:0000017308
database_cross_reference: CSP:2201-8988
database_cross_reference: CSP:4000-0104
database_cross_reference: FMA:16017
database_cross_reference: LNC:LP31813-6
database_cross_reference: MSH:D046790
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32546
database_cross_reference: NCI_CDISC:C32546
database_cross_reference: NCI_NICHD:C32546
database_cross_reference: SNM:T-59005
database_cross_reference: SNMI:T-65005
database_cross_reference: SNOMEDCT_US:20023005
database_cross_reference: UWDA:16017

Lymphoid Tissue
type: Class
subclass of: Tissues
MCID: MC00007754
PMOID: PMO:00000254
Subclass_of: Tissues
Synonym: Lymphatic Tissue
Synonym: Lymphatic Tissues
Synonym: Lymphatic tissue
Synonym: Lymphatic tissue (body structure)
Synonym: Lymphocytic tissue
Synonym: Lymphocytic tissue structure
Synonym: Lymphocytic tissue structure (body structure)
Synonym: Lymphoid Tissues
Synonym: Lymphoid tissue
Synonym: Tissue, Lymphatic
Tree Number: T1.3.7
database_cross_reference: AOD:0000027945
database_cross_reference: AOD:0000027946
database_cross_reference: CHV:0000007615
database_cross_reference: CSP:0432-5082
database_cross_reference: FMA:55220
database_cross_reference: LCH:U002764
database_cross_reference: LCH_NW:sh85079152
database_cross_reference: MSH:D008221
database_cross_reference: NCI:C13049
database_cross_reference: RCD:7N8A2
database_cross_reference: SNM:T-05200
database_cross_reference: SNMI:T-C0200
database_cross_reference: SNOMEDCT_US:181768009
database_cross_reference: SNOMEDCT_US:6969002
database_cross_reference: UWDA:55220

Tertiary Lymphoid Structures
type: Class
subclass of: Lymphoid Tissue
MCID: MC01054786
PMOID: PMO:00000255
Subclass_of: Lymphoid Tissue
Synonym: Ectopic Lymph Node
Synonym: Ectopic Lymph Nodes
Synonym: Ectopic Lymphoid Follicle
Synonym: Ectopic Lymphoid Follicles
Synonym: Ectopic Lymphoid Formation
Synonym: Ectopic Lymphoid Formations
Synonym: Ectopic Lymphoid Like Structures
Synonym: Ectopic Lymphoid Organ
Synonym: Ectopic Lymphoid Organs
Synonym: Ectopic Lymphoid Tissue
Tree Number: T1.3.7.1
database_cross_reference: MSH:D000072717
database_cross_reference: NDFRT:N0000192935

Adenoids
type: Class
subclass of: Lymphoid Tissue
MCID: MC00000347
PMOID: PMO:00000256
Subclass_of: Lymphoid Tissue
Synonym: Adenoid
Synonym: Adenoid, NOS
Synonym: Adenoidal
Synonym: Adenoidal structure
Synonym: Adenoidal structure (body structure)
Synonym: Nasopharyngeal tonsil
Synonym: PHARYNGEAL TONSIL
Synonym: Pharyngeal Tonsil
Synonym: Pharyngeal Tonsils
Synonym: Pharyngeal tonsil
Tree Number: T1.3.7.2
database_cross_reference: CHV:0000000714
database_cross_reference: CSP:0432-5082
database_cross_reference: FMA:54970
database_cross_reference: LCH:U000065
database_cross_reference: LCH_NW:sh85000840
database_cross_reference: MEDLINEPLUS:1515
database_cross_reference: MSH:D000234
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33318
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C33318
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C33318
database_cross_reference: RCD:7N204
database_cross_reference: RCD:Xa1e0
database_cross_reference: SNM:T-61300
database_cross_reference: SNMI:T-C5300
database_cross_reference: SNOMEDCT_US:55940004
database_cross_reference: UWDA:54970

Bursa of Fabricius
type: Class
subclass of: Lymphoid Tissue
MCID: MC00002032
PMOID: PMO:00000257
Subclass_of: Lymphoid Tissue
Synonym: BURSA OF FABRICIUS
Synonym: Bursa Fabricii
Synonym: Bursa Of Fabricius
Synonym: Bursa of Fabricius (body structure)
Synonym: Bursa of Fabricius structure
Synonym: Bursa of Fabricius structure (body structure)
Synonym: Fabricius Bursa
Synonym: bursa fabricius
Synonym: bursa of Fabricius
Synonym: bursa of fabricius
Tree Number: T1.3.7.3
database_cross_reference: CHV:0000002239
database_cross_reference: CSP:0432-5279
database_cross_reference: LCH_NW:sh85018202
database_cross_reference: LNC:LP7094-8
database_cross_reference: LNC:MTHU011078
database_cross_reference: MSH:D002060
database_cross_reference: NCI:C111141
database_cross_reference: NCI_CDISC:C111141
database_cross_reference: SNMI:T-C9010
database_cross_reference: SNOMEDCT_US:86689007
database_cross_reference: SNOMEDCT_VET:349371000009108

Lymph Nodes
type: Class
subclass of: Lymphoid Tissue
MCID: MC00007731
PMOID: PMO:00000258
Subclass_of: Lymphoid Tissue
Synonym: C4 LYMPH NODES
Synonym: LN - Lymph node
Synonym: LYMPH NODE
Synonym: LYMPH NODES
Synonym: Lymph Gland
Synonym: Lymph Node
Synonym: Lymph Node Structures
Synonym: Lymph gland
Synonym: Lymph gland, NOS
Synonym: Lymph node
Tree Number: T1.3.7.4
database_cross_reference: AOD:0000017506
database_cross_reference: CHV:0000007593
database_cross_reference: CSP:0432-5673
database_cross_reference: FMA:5034
database_cross_reference: ICD10AM:U000976
database_cross_reference: LCH:U002755
database_cross_reference: LCH_NW:sh85079126
database_cross_reference: LNC:LP199987-1
database_cross_reference: LNC:LP238883-5
database_cross_reference: LNC:LP72888-8
database_cross_reference: LNC:MTHU015050
database_cross_reference: LNC:MTHU055419
database_cross_reference: MEDLINEPLUS:591
database_cross_reference: MSH:D008198
database_cross_reference: MTH:U002055
database_cross_reference: NCI:C12745
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12745
database_cross_reference: NCI_NCI-GLOSS:CDR0000044489
database_cross_reference: NCI_NCI-GLOSS:CDR0000045762
database_cross_reference: NCI_NICHD:C12745
database_cross_reference: RCD:7N89.
database_cross_reference: RCD:Xa16Q
database_cross_reference: SNM:NOCODE
database_cross_reference: SNM:T-08000
database_cross_reference: SNM:U000418
database_cross_reference: SNMI:T-C4000
database_cross_reference: SNOMEDCT_US:59441001
database_cross_reference: UWDA:5034

Sentinel Lymph Node
type: Class
subclass of: Lymph Nodes
MCID: MC00529158
PMOID: PMO:00000259
Subclass_of: Lymph Nodes
Synonym: Lymph Node, Sentinel
Synonym: Lymph Nodes, Sentinel
Synonym: Node, Sentinal
Synonym: Nodes, Sentinal
Synonym: SLN
Synonym: Sentinal Node
Synonym: Sentinal Nodes
Synonym: Sentinel Lymph Nodes
Synonym: Sentinel Node
Synonym: sentinel lymph node
Tree Number: T1.3.7.4.1
database_cross_reference: MSH:D000071036
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12947
database_cross_reference: NCI_NCI-GLOSS:CDR0000045876

Germinal Center
type: Class
subclass of: Lymph Nodes
MCID: MC00098953
PMOID: PMO:00000260
Subclass_of: Lymph Nodes
Synonym: Center, Germinal
Synonym: Centers, Germinal
Synonym: Germinal Centers
Synonym: Germinal center
Synonym: Germinal center of lymph node
Synonym: Germinal centre of lymph node
Synonym: Lymph Node Germinal Center
Synonym: Lymph node germinal center
Synonym: Peripheral lymphoid tissue
Synonym: Secondary lymphoid nodule
Tree Number: T1.3.7.4.2
database_cross_reference: CHV:0000027610
database_cross_reference: FMA:55224
database_cross_reference: MSH:D018858
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13337
database_cross_reference: NCI:C49757
database_cross_reference: SNM:T-08060
database_cross_reference: SNMI:T-C4060
database_cross_reference: SNOMEDCT_US:16733004
database_cross_reference: UWDA:55224

Dendritic Cells, Follicular
type: Class
subclass of: Antigen-Presenting Cells
MCID: MC00081581
PMOID: PMO:00000261
Subclass_of: Antigen-Presenting Cells
Synonym: Dendritic Cell, Follicular
Synonym: Dendritic Reticulum Cells, Follicular
Synonym: Dendritic reticulum cell
Synonym: Follicular Dendritic Cell
Synonym: Follicular Dendritic Cells
Synonym: Follicular dendritic cell
Synonym: Follicular dendritic cell (body structure)
Synonym: Follicular dendritic cell (cell)
Synonym: Reticulum cell, dendritic
Synonym: follicular dendritic cell
Tree Number: T2.3.2
database_cross_reference: CHV:0000024750
database_cross_reference: FMA:83037
database_cross_reference: MSH:D020566
database_cross_reference: NCI:C12622
database_cross_reference: SNM:T-05111
database_cross_reference: SNMI:T-C0111
database_cross_reference: SNOMEDCT_US:56685008

Peyer's Patches
type: Class
subclass of: Lymphoid Tissue
MCID: MC00009973
PMOID: PMO:00000262
Subclass_of: Lymphoid Tissue
Synonym: Aggregated lymphoid follicle of small intestine
Synonym: Aggregated lymphoid nodules of small intestine
Synonym: Lymphoid aggregate
Synonym: Lymphoid aggregate (body structure)
Synonym: Lymphoid aggregate [dup] (body structure)
Synonym: Noduli lymphoidei aggregati intestini tenuis
Synonym: PEYER'S PATCH
Synonym: Patches, Peyer's
Synonym: Peyer Patch
Synonym: Peyer Patches
Tree Number: T1.3.7.5
database_cross_reference: AOD:0000017290
database_cross_reference: AOD:0000027779
database_cross_reference: CHV:0000009564
database_cross_reference: CSP:0432-5931
database_cross_reference: FMA:15054
database_cross_reference: FMA:76466
database_cross_reference: MSH:D010581
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12771
database_cross_reference: NCI_CDISC:C12771
database_cross_reference: SNM:T-64080
database_cross_reference: SNM:T-64082
database_cross_reference: SNMI:T-58082
database_cross_reference: SNOMEDCT_US:267190001
database_cross_reference: SNOMEDCT_US:304496003
database_cross_reference: SNOMEDCT_US:305467006
database_cross_reference: SNOMEDCT_US:57253005
database_cross_reference: UWDA:15054
database_cross_reference: UWDA:76466

Spleen
type: Class
subclass of: Lymphoid Tissue
MCID: MC00012150
PMOID: PMO:00000263
Subclass_of: Lymphoid Tissue
Synonym: C3 SPLEEN
Synonym: Lien
Synonym: Lienal
Synonym: Lieno-
Synonym: Reticuloendothelial System, Spleen
Synonym: SPLEEN
Synonym: Spleen, NOS
Synonym: Splen
Synonym: Splenic
Synonym: Splenic structure
Tree Number: T1.3.7.6
database_cross_reference: AOD:0000004631
database_cross_reference: CHV:0000011640
database_cross_reference: CSP:0432-8431
database_cross_reference: FMA:7196
database_cross_reference: LCH:U004439
database_cross_reference: LCH_NW:sh85126812
database_cross_reference: LNC:LA26010-1
database_cross_reference: LNC:LP199947-5
database_cross_reference: LNC:LP30311-2
database_cross_reference: LNC:MTHU012104
database_cross_reference: MSH:D013154
database_cross_reference: MTH:U002266
database_cross_reference: NCI:C12432
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12432
database_cross_reference: NCI_NCI-GLOSS:CDR0000046593
database_cross_reference: NCI_NCI-GLOSS:CDR0000467863
database_cross_reference: NCI_NICHD:C12432
database_cross_reference: OMIM:MTHU000222
database_cross_reference: PSY:49320
database_cross_reference: RCD:7N342
database_cross_reference: RCD:Xa0am
database_cross_reference: SNM:T-07000
database_cross_reference: SNM:U000417
database_cross_reference: SNMI:T-C3000
database_cross_reference: SNOMEDCT_US:78961009
database_cross_reference: UWDA:7196

Thymus Gland
type: Class
subclass of: Lymphoid Tissue
MCID: MC00012820
PMOID: PMO:00000264
Subclass_of: Lymphoid Tissue
Synonym: Extract, Thymus
Synonym: Extracts, Thymus
Synonym: HUMAN THYMUS
Synonym: THYMUS
Synonym: Thymus Extract
Synonym: Thymus Extracts
Synonym: Thymus Extracts [Chemical/Ingredient]
Synonym: Thymus extract
Synonym: Thymus gland
Synonym: gland thymus
Tree Number: T1.3.7.7
database_cross_reference: AOD:0000018972
database_cross_reference: CHV:0000012250
database_cross_reference: LCH:U004681
database_cross_reference: LCH_NW:sh85135146
database_cross_reference: LNC:LP36529-3
database_cross_reference: MSH:D013949
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9CC998Z1E1
database_cross_reference: NDDF:007062
database_cross_reference: NDFRT:N0000022939
database_cross_reference: NDFRT:N0000170927
database_cross_reference: RXNORM:10562
database_cross_reference: VANDF:4020844

Palatine Tonsil
type: Class
subclass of: Lymphoid Tissue
MCID: MC00012915
PMOID: PMO:00000265
Subclass_of: Lymphoid Tissue
Synonym: Faucial tonsil
Synonym: Palatine Tonsils
Synonym: Palatine tonsil
Synonym: TONSIL
Synonym: TONSIL, PALATINE
Synonym: Tonsil
Synonym: Tonsil, NOS
Synonym: Tonsil, Palatine
Synonym: Tonsilla palatina
Synonym: Tonsillar
Tree Number: T1.3.7.8
database_cross_reference: CCPSS:0035921
database_cross_reference: CHV:0000012359
database_cross_reference: CSP:2139-1223
database_cross_reference: CSP:4000-0195
database_cross_reference: FMA:9610
database_cross_reference: LCH:U004722
database_cross_reference: LCH_NW:sh85136024
database_cross_reference: MSH:D014066
database_cross_reference: MTH:U002313
database_cross_reference: NCI:C33250
database_cross_reference: NCI_CDISC:C33250
database_cross_reference: RCD:XE0K3
database_cross_reference: RCD:Xa1e2
database_cross_reference: SNM:T-61100
database_cross_reference: SNMI:T-C5100
database_cross_reference: SNOMEDCT_US:181228009
database_cross_reference: SNOMEDCT_US:75573002
database_cross_reference: UWDA:9610

Membranes
type: Class
subclass of: Tissues
MCID: MC00008023
PMOID: PMO:00000266
Subclass_of: Tissues
Synonym: Membrane
Synonym: Membrane Tissue
Synonym: Membrane Tissues
Synonym: Membranous
Synonym: Tissue membrane
Synonym: Tissue, Membrane
Synonym: Tissues, Membrane
Synonym: membrane
Synonym: membranes
Tree Number: T1.3.8
database_cross_reference: CHV:0000007915
database_cross_reference: FMA:30322
database_cross_reference: MSH:D008566
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12749
database_cross_reference: NCI_NCI-GLOSS:CDR0000046294
database_cross_reference: PSY:30560
database_cross_reference: UWDA:30322

Basilar Membrane
type: Class
subclass of: Basement Membrane
MCID: MC00001518
PMOID: PMO:00000267
Subclass_of: Basement Membrane
Synonym: BM - Basilar membrane
Synonym: Basilar Membranes
Synonym: Basilar membrane
Synonym: Basilar membrane of cochlea
Synonym: Cochlea, basilar membrane
Synonym: Membrane, Basilar
Synonym: Membranes, Basilar
Synonym: Structure of basilar membrane of cochlea
Synonym: Structure of basilar membrane of cochlea (body structure)
Tree Number: T1.3.8.1.1
database_cross_reference: FMA:75706
database_cross_reference: LCH:U000509
database_cross_reference: LCH_NW:sh85012090
database_cross_reference: MSH:D001489
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13179
database_cross_reference: RCD:Xa1DG
database_cross_reference: SNM:T-XY802
database_cross_reference: SNMI:T-AB802
database_cross_reference: SNOMEDCT_US:50862003
database_cross_reference: UWDA:75706

Descemet Membrane
type: Class
subclass of: Basement Membrane
MCID: MC00003739
PMOID: PMO:00000268
Subclass_of: Basement Membrane
Synonym: Descemet Membranes
Synonym: Descemet's Membrane
Synonym: Descemet's membrane
Synonym: Descemet's posterior elastic lamina
Synonym: Descemets Membrane
Synonym: Elastica Posterior, Lamina
Synonym: Elastica Posteriors, Lamina
Synonym: Lamina Elastica Posterior
Synonym: Lamina Elastica Posteriors
Synonym: Lamina limitans posterior
Tree Number: T1.3.8.1.2
database_cross_reference: FMA:58309
database_cross_reference: MSH:D003886
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32454
database_cross_reference: SNM:T-XX250
database_cross_reference: SNMI:T-AA250
database_cross_reference: SNOMEDCT_US:42983006
database_cross_reference: UWDA:58309

Glomerular Basement Membrane
type: Class
subclass of: Basement Membrane
subclass of: Extracellular Matrix
MCID: MC00183907
PMOID: PMO:00000269
Subclass_of: Basement Membrane
Subclass_of: Extracellular Matrix
Synonym: Basement Membrane, Glomerular
Synonym: Basement Membranes, Glomerular
Synonym: GBM
Synonym: Glomerular Basement Membranes
Synonym: Glomerular basement membrane
Synonym: Membrane, Glomerular Basement
Synonym: Membranes, Glomerular Basement
Synonym: basement glomerular membranes
Synonym: glomerular basement membrane
Tree Number: T1.3.8.1.4
Tree Number: T1.4.5.2.3
Tree Number: T2.8.5.2.3
database_cross_reference: CHV:0000042002
database_cross_reference: CSP:1680-0810
database_cross_reference: CSP:1831-6535
database_cross_reference: FMA:74274
database_cross_reference: LNC:LP68423-0
database_cross_reference: MSH:D050533
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32683
database_cross_reference: UWDA:74274

Mucous Membrane
type: Class
subclass of: Membranes
MCID: MC00008462
PMOID: PMO:00000270
Subclass_of: Membranes
Synonym: MM - Mucous membrane
Synonym: MUCOSA
Synonym: Membrane, Mucous
Synonym: Membranes, Mucous
Synonym: Mucosa
Synonym: Mucosa of organ
Synonym: Mucosal
Synonym: Mucosal (qualifier value)
Synonym: Mucosal Tissue
Synonym: Mucosal Tissues
Tree Number: T1.3.8.3
database_cross_reference: AOD:0000016909
database_cross_reference: AOD:0000017268
database_cross_reference: AOD:0000027642
database_cross_reference: CSP:1831-7474
database_cross_reference: DRUGBANK:DB00874
database_cross_reference: FMA:85355
database_cross_reference: LCH:U003051
database_cross_reference: LCH_NW:sh85088237
database_cross_reference: LNC:LP30530-7
database_cross_reference: LNC:MTHU015053
database_cross_reference: MSH:D009092
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13166
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13166
database_cross_reference: NCI_NCI-GLOSS:CDR0000257212
database_cross_reference: NCI_NCI-GLOSS:CDR0000257213
database_cross_reference: NCI_NICHD:C13166
database_cross_reference: RCD:X79YP
database_cross_reference: RCD:XaEGv
database_cross_reference: SNMI:T-00400
database_cross_reference: SNOMEDCT_US:313268005
database_cross_reference: SNOMEDCT_US:414781009
database_cross_reference: SNOMEDCT_US:74301006
database_cross_reference: UWDA:45630

Esophageal Mucosa
type: Class
subclass of: Mucous Membrane
MCID: MC00075077
PMOID: PMO:00000271
Subclass_of: Mucous Membrane
Synonym: Esophageal mucosa
Synonym: Esophageal mucous membrane
Synonym: Esophageal mucous membrane structure
Synonym: Esophageal mucous membrane structure (body structure)
Synonym: Esophageal mucous membranes
Synonym: Esophagus - mucosa
Synonym: Esophagus Mucosa
Synonym: Esophagus mucosa
Synonym: Lamina muscularis mucosae oesophageae
Synonym: Mucosa of esophagus
Tree Number: T1.3.8.3.1
database_cross_reference: CHV:0000022092
database_cross_reference: CSP:2139-1486
database_cross_reference: FMA:62996
database_cross_reference: MSH:D000071041
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32538
database_cross_reference: NCI:GTEx
database_cross_reference: SNM:T-62010
database_cross_reference: SNMI:T-56010
database_cross_reference: SNOMEDCT_US:82082004
database_cross_reference: UWDA:62996

Gastric Mucosa
type: Class
subclass of: Mucous Membrane
MCID: MC00005454
PMOID: PMO:00000272
Subclass_of: Mucous Membrane
Synonym: Gastric Mucosas
Synonym: Gastric mucosa
Synonym: Gastric mucous membrane
Synonym: Gastric mucous membrane structure
Synonym: Gastric mucous membrane structure (body structure)
Synonym: Mucosa of stomach
Synonym: Mucosa, Gastric
Synonym: Mucosas, Gastric
Synonym: Mucous membrane of stomach
Synonym: Tunica mucosa (Gaster)
Tree Number: T1.3.8.3.2
database_cross_reference: AOD:0000017269
database_cross_reference: CHV:0000005372
database_cross_reference: CSP:1250-9110
database_cross_reference: FMA:14907
database_cross_reference: LCH:U001924
database_cross_reference: LCH_NW:sh85053463
database_cross_reference: MSH:D005753
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32656
database_cross_reference: SNM:T-63010
database_cross_reference: SNMI:T-57010
database_cross_reference: SNOMEDCT_US:78653002
database_cross_reference: UWDA:14907

Enterochromaffin Cells
type: Class
subclass of: Enteroendocrine Cells
MCID: MC00004539
PMOID: PMO:00000273
Subclass_of: Enteroendocrine Cells
Synonym: 5 HT Containing Enterochromaffin Cells
Synonym: 5-HT-Containing Enterochromaffin Cell
Synonym: 5-HT-Containing Enterochromaffin Cells
Synonym: Argentaffin Cell
Synonym: Argentaffin Cells
Synonym: Argentaffin cell
Synonym: Argentaffin cells
Synonym: Argentaffin cells, NOS
Synonym: Cell, Enterochromaffin
Synonym: Cells, Enterochromaffin
Tree Number: T2.11.7.1
Tree Number: T2.12.21.1
database_cross_reference: CHV:0000004500
database_cross_reference: CSP:0605-5566
database_cross_reference: FMA:83132
database_cross_reference: MSH:D004759
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12575
database_cross_reference: NCI:C32140
database_cross_reference: SNM:T-64140
database_cross_reference: SNMI:T-58140
database_cross_reference: SNOMEDCT_US:3789000

Parietal Cells, Gastric
type: Class
subclass of: Epithelial Cells
MCID: MC00009745
PMOID: PMO:00000274
Subclass_of: Epithelial Cells
Synonym: Cell, Gastric Parietal
Synonym: Cell, Oxyntic
Synonym: Cells, Gastric Parietal
Synonym: Cells, Oxyntic
Synonym: Gastric Parietal Cell
Synonym: Gastric Parietal Cells
Synonym: Gastric parietal cell
Synonym: Gastric parietal cell (body structure)
Synonym: Gastric parietal cell (cell)
Synonym: Oxyntic Cell
Tree Number: T2.12.12
database_cross_reference: CHV:0000009315
database_cross_reference: FMA:62901
database_cross_reference: LNC:LP16734-3
database_cross_reference: MSH:D010295
database_cross_reference: NCI:C12594
database_cross_reference: SNM:T-63080
database_cross_reference: SNMI:T-57080
database_cross_reference: SNOMEDCT_US:57041003
database_cross_reference: UWDA:62901

Gastrin-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
MCID: MC00163985
PMOID: PMO:00000275
Subclass_of: Enteroendocrine Cells
Synonym: Cell, Gastrin-Secreting
Synonym: Cells, Gastrin-Secreting
Synonym: G Cell
Synonym: G Cells
Synonym: G cell
Synonym: G-Cell
Synonym: Gastrin Cell
Synonym: Gastrin Cells
Synonym: Gastrin Secreting Cell
Synonym: Gastrin Secreting Cells
Tree Number: T2.11.7.3
Tree Number: T2.12.21.3
database_cross_reference: CHV:0000038380
database_cross_reference: FMA:67609
database_cross_reference: MSH:D019863
database_cross_reference: NCI:C12577

Somatostatin-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
MCID: MC00163986
PMOID: PMO:00000276
Subclass_of: Enteroendocrine Cells
Synonym: D Cell
Synonym: D Cells
Synonym: Delta Cell
Synonym: Delta cell
Synonym: Somatostatin Cell
Synonym: Somatostatin Cells
Synonym: Somatostatin Secreting Cell
Synonym: Somatostatin Secreting Cells
Synonym: Somatostatin-Secreting Cell
Synonym: cell d
Tree Number: T2.11.7.4
Tree Number: T2.12.21.4
database_cross_reference: CHV:0000038381
database_cross_reference: FMA:86572
database_cross_reference: MSH:D019864
database_cross_reference: NCI:C12574

Chief Cells, Gastric
type: Class
subclass of: Epithelial Cells
MCID: MC00163989
PMOID: PMO:00000277
Subclass_of: Epithelial Cells
Synonym: Cell, Gastric Zymogenic
Synonym: Cells, Gastric Zymogenic
Synonym: Chief Cell of the Stomach
Synonym: Chief Cell, Gastric
Synonym: Chief cell of stomach
Synonym: Gastric Chief Cell
Synonym: Gastric Chief Cells
Synonym: Gastric Zymogenic Cell
Synonym: Gastric Zymogenic Cells
Synonym: Gastric chief cell
Tree Number: T2.12.22
database_cross_reference: AOD:0000017267
database_cross_reference: FMA:62902
database_cross_reference: MSH:D019872
database_cross_reference: NCI:C32305
database_cross_reference: SNM:T-63070
database_cross_reference: SNMI:T-57070
database_cross_reference: SNOMEDCT_US:70935009
database_cross_reference: UWDA:62902

Hymen
type: Class
subclass of: Mucous Membrane
MCID: MC00006523
PMOID: PMO:00000278
Subclass_of: Mucous Membrane
Synonym: Hymen of vagina
Synonym: Hymen vaginae
Synonym: Structure of hymen
Synonym: Structure of hymen (body structure)
Synonym: Vaginal hymen
Synonym: hymen
Synonym: hymen of vagina
Synonym: hymens
Tree Number: T1.3.8.3.3
database_cross_reference: CHV:0000006395
database_cross_reference: FMA:20005
database_cross_reference: MSH:D006924
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32750
database_cross_reference: RCD:X756P
database_cross_reference: SNM:T-81400
database_cross_reference: SNMI:T-82400
database_cross_reference: SNOMEDCT_US:27907006
database_cross_reference: UWDA:20005

Intestinal Mucosa
type: Class
subclass of: Mucous Membrane
MCID: MC00006955
PMOID: PMO:00000279
Subclass_of: Mucous Membrane
Synonym: Intestinal mucosa
Synonym: Intestinal mucosa, NOS
Synonym: Intestinal mucous membrane
Synonym: Intestinal mucous membrane structure
Synonym: Intestinal mucous membrane structure (body structure)
Synonym: Intestinal mucous membrane, NOS
Synonym: Mucosa of intestine
Synonym: Mucosa, Intestinal
Synonym: intestinal membrane mucous
Synonym: intestinal mucosa
Tree Number: T1.3.8.3.4
database_cross_reference: AOD:0000017275
database_cross_reference: CHV:0000006857
database_cross_reference: CSP:1250-5140
database_cross_reference: FMA:15695
database_cross_reference: LCH_NW:sh88005282
database_cross_reference: MSH:D007413
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C49241
database_cross_reference: SNM:T-50130
database_cross_reference: SNMI:T-50510
database_cross_reference: SNOMEDCT_US:68534000
database_cross_reference: UWDA:15695

Paneth Cells
type: Class
subclass of: Epithelial Cells
MCID: MC00075146
PMOID: PMO:00000280
Subclass_of: Epithelial Cells
Synonym: Cells, Paneth
Synonym: Paneth Cell
Synonym: Paneth cell
Synonym: Paneth cell (body structure)
Synonym: Paneth cell (cell)
Synonym: paneth cell
Synonym: paneth cells
Tree Number: T2.12.23
database_cross_reference: CHV:0000022104
database_cross_reference: FMA:62897
database_cross_reference: MSH:D019879
database_cross_reference: NCI:C12593
database_cross_reference: SNM:T-64130
database_cross_reference: SNMI:T-58130
database_cross_reference: SNOMEDCT_US:84907006
database_cross_reference: UWDA:62897

Goblet Cells
type: Class
subclass of: Epithelial Cells
MCID: MC00162084
PMOID: PMO:00000281
Subclass_of: Epithelial Cells
Synonym: Cell, Goblet
Synonym: Cells, Goblet
Synonym: Goblet Cell
Synonym: Goblet cell
Synonym: Mucous cell
Synonym: cell goblets
Synonym: cells goblet
Synonym: goblet cell
Synonym: goblet cells
Synonym: mucous cell
Tree Number: T2.12.24
database_cross_reference: CHV:0000037527
database_cross_reference: CSP:4005-0023
database_cross_reference: FMA:13148
database_cross_reference: MSH:D020397
database_cross_reference: NCI:C12586
database_cross_reference: NCI:TCGA
database_cross_reference: UWDA:13148

Enterocytes
type: Class
subclass of: Epithelial Cells
MCID: MC00223866
PMOID: PMO:00000282
Subclass_of: Epithelial Cells
Synonym: Enterocyte
Synonym: enterocyte
Synonym: enterocytes
Tree Number: T2.12.25
database_cross_reference: AOD:0000017274
database_cross_reference: CHV:0000043655
database_cross_reference: FMA:62122
database_cross_reference: LNC:LP135744-3
database_cross_reference: MSH:D020895
database_cross_reference: NCI:C12585
database_cross_reference: UWDA:62122

Mouth Mucosa
type: Class
subclass of: Mucous Membrane
MCID: MC00008434
PMOID: PMO:00000283
Subclass_of: Mucous Membrane
Synonym: MUCOSA, ORAL
Synonym: Mouth mucosa
Synonym: Mucosa of mouth
Synonym: Mucosa of the mouth
Synonym: Mucosa, Mouth
Synonym: Mucosa, Oral
Synonym: Mucous membrane of mouth
Synonym: ORAL MUCOSA
Synonym: Oral Mucosa
Synonym: Oral mucosa
Tree Number: T1.3.8.3.5
database_cross_reference: CHV:0000008287
database_cross_reference: CHV:0000052722
database_cross_reference: CSP:2139-1486
database_cross_reference: FMA:59660
database_cross_reference: LCH:U005801
database_cross_reference: LCH_NW:sh85095245
database_cross_reference: MSH:D009061
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C77637
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C77637
database_cross_reference: RCD:X75DA
database_cross_reference: SNM:T-51030
database_cross_reference: SNMI:T-51300
database_cross_reference: SNOMEDCT_US:113277000
database_cross_reference: SNOMEDCT_US:409874000
database_cross_reference: UWDA:59660

Respiratory Mucosa
type: Class
subclass of: Mucous Membrane
MCID: MC00259143
PMOID: PMO:00000284
Subclass_of: Mucous Membrane
Synonym: Mucosa, Respiratory
Synonym: RESP MUCOSA
Synonym: Respiratory mucosa
Tree Number: T1.3.8.3.6
database_cross_reference: LCH_NW:sh88004529
database_cross_reference: MSH:D020545

Serous Membrane
type: Class
subclass of: Membranes
MCID: MC00011777
PMOID: PMO:00000289
Subclass_of: Membranes
Synonym: Membrane, Serous
Synonym: Membranes, Serous
Synonym: Serosa
Synonym: Serous Membranes
Synonym: Serous membrane
Synonym: Serous membrane structure
Synonym: Serous membrane structure (body structure)
Synonym: Serous membrane, NOS
Synonym: Tunica serosa
Synonym: Wall of serous sac
Tree Number: T1.3.8.4
database_cross_reference: AOD:0000016910
database_cross_reference: AOD:0000027643
database_cross_reference: AOD:0000027644
database_cross_reference: CHV:0000011224
database_cross_reference: CSP:0461-0833
database_cross_reference: FMA:45637
database_cross_reference: FMA:9581
database_cross_reference: MSH:D012704
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13169
database_cross_reference: NCI_NCI-GLOSS:CDR0000454933
database_cross_reference: NCI_NCI-GLOSS:CDR0000454934
database_cross_reference: SNM:T-1X120
database_cross_reference: SNMI:T-1A110
database_cross_reference: SNOMEDCT_US:75858005
database_cross_reference: UWDA:45637
database_cross_reference: UWDA:9581

Pericardium
type: Class
subclass of: Serous Membrane
MCID: MC00009911
PMOID: PMO:00000290
Subclass_of: Serous Membrane
Synonym: 39 PERICARDIUM
Synonym: PERICARDIUM
Synonym: Pericardial
Synonym: Pericardial sac
Synonym: Pericardial sac structure
Synonym: Pericardial sac structure (body structure)
Synonym: Pericardial structure
Synonym: Pericardial structure (body structure)
Synonym: Pericardium, NOS
Synonym: pericardial sac
Tree Number: T1.3.8.4.1
database_cross_reference: AOD:0000017167
database_cross_reference: CHV:0000009491
database_cross_reference: CSP:1390-3467
database_cross_reference: FMA:9868
database_cross_reference: FMA:9869
database_cross_reference: LCH:U003549
database_cross_reference: LCH_NW:sh85099851
database_cross_reference: MSH:D010496
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13005
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13005
database_cross_reference: NCI_NICHD:C13005
database_cross_reference: RCD:7N414
database_cross_reference: RCD:Xa0eS
database_cross_reference: SNM:T-31000
database_cross_reference: SNM:U000437
database_cross_reference: SNMI:T-39000
database_cross_reference: SNOMEDCT_US:24949005
database_cross_reference: SNOMEDCT_US:76848001
database_cross_reference: UWDA:9868
database_cross_reference: UWDA:9869

Pleura
type: Class
subclass of: Serous Membrane
MCID: MC00010327
PMOID: PMO:00000292
Subclass_of: Serous Membrane
Synonym: 29 PLEURA
Synonym: PLEURA
Synonym: Pleura, NOS
Synonym: Pleural
Synonym: Pleural Tissue
Synonym: Pleural membrane structure
Synonym: Pleural membrane structure (body structure)
Synonym: Pleural structure
Synonym: Pleuro-
Synonym: Wall of pleural sac
Tree Number: T1.3.8.4.3
database_cross_reference: AOD:0000017241
database_cross_reference: CHV:0000009849
database_cross_reference: CST:RES/PLRA
database_cross_reference: FMA:9583
database_cross_reference: LCH:U003722
database_cross_reference: LCH_NW:sh85103493
database_cross_reference: LNC:LA4680-0
database_cross_reference: LNC:LP124831-1
database_cross_reference: LNC:LP199939-2
database_cross_reference: LNC:MTHU040199
database_cross_reference: MSH:D010994
database_cross_reference: MTH:U002174
database_cross_reference: NCI:C12469
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12469
database_cross_reference: NCI_NCI-GLOSS:CDR0000045842
database_cross_reference: NCI_NICHD:C12469
database_cross_reference: RCD:7N800
database_cross_reference: RCD:XC0KX
database_cross_reference: RCD:Xa0cX
database_cross_reference: SNM:T-29000
database_cross_reference: SNM:U000435
database_cross_reference: SNMI:T-29000
database_cross_reference: SNOMEDCT_US:3120008
database_cross_reference: UWDA:9583

Muscles
type: Class
subclass of: Tissues
MCID: MC00008495
PMOID: PMO:00000293
Subclass_of: Tissues
Synonym: MUSCLE
Synonym: Muscle
Synonym: Muscle (organ)
Synonym: Muscle Tissue
Synonym: Muscle Tissues
Synonym: Muscle organ
Synonym: Muscle tissue
Synonym: Muscle tissue (body structure)
Synonym: Muscle, NOS
Synonym: Muscles, NOS
Tree Number: T1.3.9
database_cross_reference: AOD:0000002457
database_cross_reference: AOD:0000027635
database_cross_reference: CHV:0000008358
database_cross_reference: CHV:0000037494
database_cross_reference: CSP:1979-3864
database_cross_reference: DRUGBANK:DB00825
database_cross_reference: DRUGBANK:DB01744
database_cross_reference: DRUGBANK:DB09543
database_cross_reference: FMA:30316
database_cross_reference: FMA:5022
database_cross_reference: LCH:U003065
database_cross_reference: LCH:U006531
database_cross_reference: LCH_NW:sh85088687
database_cross_reference: LNC:LP199993-9
database_cross_reference: LNC:LP20705-7
database_cross_reference: LNC:LP32940-6
database_cross_reference: LNC:LP33444-8
database_cross_reference: LNC:MTHU016812
database_cross_reference: MSH:D009132
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12435
database_cross_reference: NCI:C13056
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13056
database_cross_reference: NCI_NICHD:C13056
database_cross_reference: OMIM:MTHU023760
database_cross_reference: PSY:32580
database_cross_reference: RCD:X74sw
database_cross_reference: SNM:T-13001
database_cross_reference: SNMI:T-13000
database_cross_reference: SNMI:T-13001
database_cross_reference: SNMI:T-13009
database_cross_reference: SNOMEDCT_US:71616004
database_cross_reference: SNOMEDCT_US:79984008
database_cross_reference: SNOMEDCT_US:91727004
database_cross_reference: SNOMEDCT_VET:91727004
database_cross_reference: UWDA:30316
database_cross_reference: UWDA:5022

Muscle, Smooth
type: Class
subclass of: Muscles
MCID: MC00426039
PMOID: PMO:00000294
Subclass_of: Muscles
Synonym: 1A5 SMOOTH MUSCLE
Synonym: Involuntary Muscle
Synonym: Involuntary Muscles
Synonym: Involuntary muscle
Synonym: MUSCLE, SMOOTH
Synonym: Muscle, Involuntary
Synonym: Muscles, Involuntary
Synonym: Muscles, Smooth
Synonym: Non-striated muscle
Synonym: Portion of smooth muscle tissue
Tree Number: T1.3.9.1
database_cross_reference: AOD:0000016905
database_cross_reference: AOD:0000027640
database_cross_reference: CHV:0000008357
database_cross_reference: CHV:0000056700
database_cross_reference: CSP:1982-1959
database_cross_reference: FMA:14070
database_cross_reference: LCH_NW:sh85123706
database_cross_reference: LNC:LP16762-4
database_cross_reference: MSH:D009130
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12437
database_cross_reference: NCI_CDISC:SDTM-SPECTYPE
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: SNM:T-1X300
database_cross_reference: SNM:U000423
database_cross_reference: SNMI:T-1A500
database_cross_reference: SNOMEDCT_US:122447002
database_cross_reference: SNOMEDCT_US:39822001
database_cross_reference: UWDA:14070

Muscle, Smooth, Vascular
type: Class
subclass of: Muscle, Smooth
MCID: MC00008494
PMOID: PMO:00000295
Subclass_of: Muscle, Smooth
Synonym: Muscle, Vascular Smooth
Synonym: Muscles, Vascular Smooth
Synonym: Smooth Muscle, Vascular
Synonym: Smooth Muscles, Vascular
Synonym: Vascular Smooth Muscle
Synonym: Vascular Smooth Muscles
Synonym: Vascular smooth muscle
Synonym: vascular smooth muscle
Tree Number: T1.3.9.1.1
database_cross_reference: CSP:0581-4865
database_cross_reference: LCH:U004900
database_cross_reference: LCH_NW:sh85142361
database_cross_reference: MSH:D009131

Myometrium
type: Class
subclass of: Muscle, Smooth
MCID: MC00008572
PMOID: PMO:00000296
Subclass_of: Muscle, Smooth
Synonym: 836 MYOMETRIUM
Synonym: MYOMETRIUM
Synonym: Muscle, Uterine
Synonym: Muscles, Uterine
Synonym: Myometrial structure
Synonym: Myometrial structure (body structure)
Synonym: Myometrium, NOS
Synonym: Tunica muscularis (Myometrium)
Synonym: Tunica muscularis uteri
Synonym: Uterine Muscle
Tree Number: T1.3.9.1.2
database_cross_reference: AOD:0000017406
database_cross_reference: CHV:0000008436
database_cross_reference: CSP:2587-5224
database_cross_reference: FMA:17743
database_cross_reference: LCH:U003100
database_cross_reference: LCH_NW:sh85089265
database_cross_reference: MSH:D009215
database_cross_reference: MTH:U002096
database_cross_reference: NCI:C12314
database_cross_reference: NCI_CDISC:C12314
database_cross_reference: NCI_NCI-GLOSS:CDR0000046280
database_cross_reference: NCI_NICHD:C12314
database_cross_reference: RCD:Xa1E5
database_cross_reference: SNM:T-85000
database_cross_reference: SNM:U000485
database_cross_reference: SNMI:T-83600
database_cross_reference: SNOMEDCT_US:27232003
database_cross_reference: UWDA:17743

Muscle, Striated
type: Class
subclass of: Muscles
MCID: MC00454351
PMOID: PMO:00000297
Subclass_of: Muscles
Synonym: MUSCLE STRIATED
Synonym: Muscles, Striated
Synonym: STRIATED MUSCLE TISSUE
Synonym: Striated Muscle
Synonym: Striated Muscle Tissue
Synonym: Striated Muscles
Synonym: Striated muscle
Synonym: Striated muscle (tissue)
Synonym: Striated muscle (tissue) (body structure)
Synonym: Striated muscle system
Tree Number: T1.3.9.2
database_cross_reference: AOD:0000016904
database_cross_reference: CSP:1982-2542
database_cross_reference: FMA:67905
database_cross_reference: LCH_NW:sh85128719
database_cross_reference: LNC:LP16768-1
database_cross_reference: MSH:D054792
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12436
database_cross_reference: NCI_CDISC:C12436
database_cross_reference: SNMI:T-13000
database_cross_reference: SNMI:T-13001
database_cross_reference: SNOMEDCT_US:118252003
database_cross_reference: SNOMEDCT_US:127954009
database_cross_reference: SNOMEDCT_US:71616004
database_cross_reference: SNOMEDCT_US:79984008
database_cross_reference: UWDA:67905

Myocardium
type: Class
subclass of: Muscle, Striated
MCID: MC00008564
PMOID: PMO:00000298
Subclass_of: Muscle, Striated
Synonym: CARDIAC MUSCLE TISSUE
Synonym: Cardiac Muscle
Synonym: Cardiac Muscles
Synonym: Cardiac muscle
Synonym: Cardiac muscle (tissue)
Synonym: Cardiac muscle (tissue) (body structure)
Synonym: Cardiac muscle tissue
Synonym: Heart Muscle
Synonym: Heart Muscles
Synonym: Heart muscle
Tree Number: T1.3.9.2.1
database_cross_reference: AOD:0000017170
database_cross_reference: AOD:0000027719
database_cross_reference: CHV:0000008426
database_cross_reference: CHV:0000056701
database_cross_reference: CSP:1390-2774
database_cross_reference: FMA:14068
database_cross_reference: FMA:9462
database_cross_reference: LCH_NW:sh85059694
database_cross_reference: LNC:LP101987-8
database_cross_reference: LNC:LP16727-7
database_cross_reference: LNC:MTHU050170
database_cross_reference: MSH:D009206
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12371
database_cross_reference: NCI_CDISC:C12371
database_cross_reference: PSY:32830
database_cross_reference: RCD:XC0Is
database_cross_reference: SNM:T-33010
database_cross_reference: SNMI:T-32020
database_cross_reference: SNOMEDCT_US:122448007
database_cross_reference: SNOMEDCT_US:74281007
database_cross_reference: UWDA:14068
database_cross_reference: UWDA:9462

Myocytes, Cardiac
type: Class
subclass of: Muscle Cells
MCID: MC00073976
PMOID: PMO:00000299
Subclass_of: Muscle Cells
Synonym: Cardiac Muscle Cell
Synonym: Cardiac Muscle Cells
Synonym: Cardiac Myocyte
Synonym: Cardiac Myocytes
Synonym: Cardiac muscle cell
Synonym: Cardiac muscle fiber
Synonym: Cardiac myocyte
Synonym: Cardiac myocyte (cell)
Synonym: Cardiac myocyte, NOS
Synonym: Cardiac myofiber
Tree Number: T2.19.2
database_cross_reference: AOD:0000017168
database_cross_reference: CHV:0000021955
database_cross_reference: CSP:4009-0006
database_cross_reference: FMA:14067
database_cross_reference: FMA:260659
database_cross_reference: MSH:D032383
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13002
database_cross_reference: SNMI:T-32030
database_cross_reference: SNOMEDCT_US:86441007
database_cross_reference: SNOMEDCT_VET:86441007
database_cross_reference: UWDA:14067

Myoblasts, Cardiac
type: Class
subclass of: Myoblasts
MCID: MC00377759
PMOID: PMO:00000300
Subclass_of: Myoblasts
Synonym: Cardiac Myoblast
Synonym: Cardiac Myoblasts
Synonym: Cardiac myoblast
Synonym: Myoblast, Cardiac
Synonym: cardiac myoblast
Synonym: cardiac myoblasts
Tree Number: T2.34.4.1
database_cross_reference: CHV:0000054911
database_cross_reference: FMA:84797
database_cross_reference: MSH:D032386

Myofibrils
type: Class
subclass of: Muscle, Striated
subclass of: Myocytes, Cardiac
subclass of: Muscle Fibers, Skeletal
MCID: MC00008569
PMOID: PMO:00000301
Subclass_of: Muscle Fibers, Skeletal
Subclass_of: Muscle, Striated
Subclass_of: Myocytes, Cardiac
Synonym: Myofibril
Synonym: Myofibril (substance)
Synonym: Myofibril, NOS
Synonym: Myofibrilla
Synonym: fibers muscle striated
Synonym: myofibril
Synonym: striated muscle fiber
Synonym: striated muscle fibre
Tree Number: T1.3.9.2.2
Tree Number: T2.19.1.1
Tree Number: T2.19.2.1
database_cross_reference: AOD:0000016900
database_cross_reference: CHV:0000008431
database_cross_reference: CSP:1980-8848
database_cross_reference: FMA:67718
database_cross_reference: GO:GO:0030016
database_cross_reference: MSH:D009210
database_cross_reference: SNMI:T-13020
database_cross_reference: SNOMEDCT_US:105583006
database_cross_reference: UWDA:67718

Sarcomeres
type: Class
subclass of: Myofibrils
MCID: MC00011607
PMOID: PMO:00000302
Subclass_of: Myofibrils
Synonym: Sarcomere
Synonym: sarcomere
Synonym: sarcomeres
Tree Number: T2.19.1.1.1
Tree Number: T2.19.2.1.1
database_cross_reference: AOD:0000016902
database_cross_reference: CHV:0000011050
database_cross_reference: CSP:1975-6437
database_cross_reference: FMA:67895
database_cross_reference: GO:GO:0030017
database_cross_reference: MSH:D012518
database_cross_reference: NCI:C87821
database_cross_reference: UWDA:67895

Muscle, Skeletal
type: Class
subclass of: Muscle, Striated
MCID: MC00081732
PMOID: PMO:00000303
Subclass_of: Muscle, Striated
Synonym: MUSCLE SKELETAL
Synonym: MUSCLE VOLUNTARY
Synonym: MUSCLE, SKELETAL
Synonym: Muscle, Voluntary
Synonym: Muscles, Skeletal
Synonym: Muscles, Voluntary
Synonym: SKELETAL MUSCLE TISSUE
Synonym: Skeletal Muscle
Synonym: Skeletal Muscle Tissue
Synonym: Skeletal Muscles
Tree Number: T1.3.9.2.3
database_cross_reference: AOD:0000017042
database_cross_reference: AOD:0000027668
database_cross_reference: CHV:0000024926
database_cross_reference: CSP:1982-2542
database_cross_reference: FMA:14069
database_cross_reference: MSH:D018482
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13050
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13050
database_cross_reference: NCI_CDISC:SDTM-SPECTYPE
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: RCD:X74sw
database_cross_reference: RCD:Xa1Pu
database_cross_reference: SNM:T-13000
database_cross_reference: SNMI:T-13000
database_cross_reference: SNOMEDCT_US:127954009
database_cross_reference: SNOMEDCT_US:79984008
database_cross_reference: UWDA:14069

Muscle Fibers, Skeletal
type: Class
subclass of: Muscle Cells
MCID: MC00577228
PMOID: PMO:00000306
Subclass_of: Muscle Cells
Synonym: Fiber, Skeletal Muscle
Synonym: Fibers, Skeletal Muscle
Synonym: Muscle Fiber, Skeletal
Synonym: Myocyte, Skeletal
Synonym: Myocytes, Skeletal
Synonym: Myocytus striatus
Synonym: Myotube
Synonym: Myotubes
Synonym: Rhabdomyocyte
Synonym: Skeletal Fiber
Tree Number: T2.19.1
database_cross_reference: CHV:0000021683
database_cross_reference: FMA:9727
database_cross_reference: MSH:D018485
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13000
database_cross_reference: NCI:C33558
database_cross_reference: NCI:C48687
database_cross_reference: SNM:T-13010
database_cross_reference: SNMI:T-13010
database_cross_reference: SNOMEDCT_US:80985008
database_cross_reference: UWDA:9727

Muscle Fibers, Fast-Twitch
type: Class
subclass of: Muscle Fibers, Skeletal
MCID: MC00081776
PMOID: PMO:00000308
Subclass_of: Muscle Fibers, Skeletal
Synonym: Fast-Twitch Muscle Fiber
Synonym: Fast-Twitch Muscle Fibers
Synonym: Fast-twitch muscle fiber
Synonym: Fiber, Fast-Twitch Muscle
Synonym: Fibers, Fast-Twitch Muscle
Synonym: Muscle Fiber, Fast-Twitch
Synonym: Muscle Fibers, Fast Twitch
Synonym: Muscle Fibers, Type II
Synonym: Skeletal muscle fiber, type II
Synonym: Skeletal muscle fiber, type II (cell structure)
Tree Number: T2.19.1.2
database_cross_reference: FMA:84414
database_cross_reference: MSH:D018656
database_cross_reference: NCI:C12613
database_cross_reference: SNM:T-13012
database_cross_reference: SNMI:T-13012
database_cross_reference: SNOMEDCT_US:87812003

Muscle Fibers, Slow-Twitch
type: Class
subclass of: Muscle Fibers, Skeletal
MCID: MC00081777
PMOID: PMO:00000309
Subclass_of: Muscle Fibers, Skeletal
Synonym: Fiber, Slow-Twitch Muscle
Synonym: Fibers, Slow-Twitch Muscle
Synonym: Muscle Fiber, Slow-Twitch
Synonym: Muscle Fibers, Slow Twitch
Synonym: Muscle Fibers, Type I
Synonym: Skeletal muscle fiber, type I
Synonym: Skeletal muscle fiber, type I (cell structure)
Synonym: Skeletal muscle fiber, type I (cell)
Synonym: Slow-Twitch Muscle Fiber
Synonym: Slow-Twitch Muscle Fibers
Tree Number: T2.19.1.3
database_cross_reference: CHV:0000025014
database_cross_reference: FMA:84413
database_cross_reference: MSH:D018657
database_cross_reference: NCI:C12614
database_cross_reference: SNM:T-13011
database_cross_reference: SNMI:T-13011
database_cross_reference: SNOMEDCT_US:36499009

Nerve Tissue
type: Class
subclass of: Tissues
MCID: MC00008789
PMOID: PMO:00000310
Subclass_of: Tissues
Synonym: A02-A03 NEURONS, TRACTS AND FIBERS
Synonym: NERVE
Synonym: NEURONS, TRACTS AND FIBERS
Synonym: Nerve Tissues
Synonym: Nerve tissue
Synonym: Nervous Tissue
Synonym: Nervous Tissues
Synonym: Nervous tissue
Synonym: Nervous tissue (body structure)
Synonym: Neural tissue
Tree Number: T1.3.10
database_cross_reference: AOD:0000017763
database_cross_reference: CHV:0000008603
database_cross_reference: FMA:9642
database_cross_reference: LCH:U003163
database_cross_reference: LCH_NW:sh85090897
database_cross_reference: MSH:D009417
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13052
database_cross_reference: NCI_CDISC:C13052
database_cross_reference: PSY:33460
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:T-A0200
database_cross_reference: SNMI:T-A0305
database_cross_reference: SNOMEDCT_US:110657001
database_cross_reference: SNOMEDCT_US:91728009
database_cross_reference: UWDA:9642

Ependyma
type: Class
subclass of: Nerve Tissue
MCID: MC00004574
PMOID: PMO:00000311
Subclass_of: Nerve Tissue
Synonym: Ependyma (body structure)
Synonym: Ependyma of neuraxis
Synonym: Ependyma, NOS
Synonym: Ependymal Tissue
Synonym: Ependymas
Synonym: Lamina epithelialis
Synonym: ependyma
Tree Number: T1.3.10.1
database_cross_reference: CHV:0000004533
database_cross_reference: CSP:0476-6742
database_cross_reference: FMA:242791
database_cross_reference: LCH:U001622
database_cross_reference: LCH_NW:sh85044249
database_cross_reference: MSH:D004805
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13078
database_cross_reference: NCI_NCI-GLOSS:CDR0000540759
database_cross_reference: NEU:1856
database_cross_reference: PSY:17650
database_cross_reference: SNM:T-X1610
database_cross_reference: SNMI:T-A1610
database_cross_reference: SNOMEDCT_US:12766003

Myelin Sheath
type: Class
subclass of: Nerve Tissue
subclass of: Cell Membrane Structures
subclass of: Oligodendroglia
subclass of: Schwann Cells
subclass of: Nerve Fibers, Myelinated
MCID: MC00008535
PMOID: PMO:00000312
Subclass_of: Cell Membrane Structures
Subclass_of: Nerve Fibers, Myelinated
Subclass_of: Nerve Tissue
Subclass_of: Oligodendroglia
Subclass_of: Schwann Cells
Synonym: Myelin
Synonym: Myelin Sheaths
Synonym: Myelin sheath
Synonym: Myelin sheath structure
Synonym: Myelin sheath structure (body structure)
Synonym: Myelin sheath structure (cell structure)
Synonym: Myelin sheath, NOS
Synonym: Myelinated
Synonym: Sheath, Myelin
Synonym: Sheaths, Myelin
Tree Number: T1.3.10.2
Tree Number: T1.4.1.6.3
Tree Number: T2.22.3.1
Tree Number: T2.22.4.1
Tree Number: T2.23.6.5.1
Tree Number: T2.23.7.1
Tree Number: T2.8.1.6.3
database_cross_reference: AOD:0000017766
database_cross_reference: AOD:0000028042
database_cross_reference: CHV:0000008403
database_cross_reference: FMA:62983
database_cross_reference: GO:GO:0043209
database_cross_reference: LCH:U003087
database_cross_reference: LCH_NW:sh85089215
database_cross_reference: MSH:D009186
database_cross_reference: MTH:U002094
database_cross_reference: NCI:C13261
database_cross_reference: NCI_NCI-GLOSS:CDR0000046276
database_cross_reference: PSY:32780
database_cross_reference: SNM:T-X0360
database_cross_reference: SNMI:T-A0360
database_cross_reference: SNOMEDCT_US:23879005
database_cross_reference: UWDA:62983

Neurilemma
type: Class
subclass of: Myelin Sheath
MCID: MC00008813
PMOID: PMO:00000313
Subclass_of: Myelin Sheath
Synonym: Neurilemma (body structure)
Synonym: Neurilemma (cell structure)
Synonym: Neurolemma
Synonym: Schwann Sheath
Synonym: Schwann sheath
Synonym: Schwann's membrane
Synonym: Sheath of Schwann
Synonym: Sheath, Schwann
Synonym: neurilemma
Synonym: neurolemma
Tree Number: T1.3.10.2.1
Tree Number: T2.22.4.1.1
database_cross_reference: AOD:0000017767
database_cross_reference: AOD:0000028043
database_cross_reference: AOD:0000028044
database_cross_reference: AOD:0000028045
database_cross_reference: CHV:0000008623
database_cross_reference: CSP:2047-3242
database_cross_reference: FMA:62976
database_cross_reference: MSH:D009441
database_cross_reference: NCI:C33544
database_cross_reference: SNM:T-X0530
database_cross_reference: SNMI:T-A0530
database_cross_reference: SNOMEDCT_US:71481009
database_cross_reference: UWDA:62976

Ranvier's Nodes
type: Class
subclass of: Myelin Sheath
subclass of: Cell Membrane Structures
PMOID: PMO:00000314
Subclass_of: Cell Membrane Structures
Subclass_of: Myelin Sheath
Tree Number: T1.3.10.2.2
Tree Number: T1.4.1.6.5
Tree Number: T2.22.4.1.2
Tree Number: T2.23.7.1.1
Tree Number: T2.8.1.6.5

Organoids
type: Class
subclass of: Tissues
MCID: MC00009230
PMOID: PMO:00000315
Subclass_of: Tissues
Synonym: Organoid
Synonym: organoid
Synonym: organoids
Tree Number: T1.3.11
database_cross_reference: CHV:0000009027
database_cross_reference: MSH:D009940

Surgically-Created Structures
type: Class
subclass of: Tissues
MCID: MC00163948
PMOID: PMO:00000316
Subclass_of: Tissues
Synonym: STRUCTURE SURG CREATED
Synonym: STRUCTURES SURG CREATED
Synonym: SURG CREATED STRUCTURE
Synonym: SURG CREATED STRUCTURES
Synonym: Structure, Surgically Created
Synonym: Structure, Surgically-Created
Synonym: Structures, Surgically Created
Synonym: Structures, Surgically-Created
Synonym: Surgically Created Structure
Synonym: Surgically Created Structures
Tree Number: T1.3.12
database_cross_reference: MSH:D019738
database_cross_reference: NCI:C25761

Surgical Flaps
type: Class
subclass of: Surgically-Created Structures
MCID: MC00012457
PMOID: PMO:00000317
Subclass_of: Surgically-Created Structures
Synonym: FLAP SURG
Synonym: FLAPS SURG
Synonym: Flap
Synonym: Flap (attribute)
Synonym: Flap (substance)
Synonym: Flap Graft
Synonym: Flap Transplant
Synonym: Flap, Surgical
Synonym: Flaps
Synonym: Flaps (substance)
Tree Number: T1.3.12.1
database_cross_reference: AOD:0000008149
database_cross_reference: CHV:0000011926
database_cross_reference: MSH:D013524
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C127814
database_cross_reference: RCD:X75U0
database_cross_reference: RCD:X79YU
database_cross_reference: RCD:Zw050
database_cross_reference: RCDSY:Zw050
database_cross_reference: SNOMEDCT_US:246343008
database_cross_reference: SNOMEDCT_US:256683004
database_cross_reference: SNOMEDCT_US:316918004

Free Tissue Flaps
type: Class
subclass of: Surgical Flaps
MCID: MC00147596
PMOID: PMO:00000318
Subclass_of: Surgical Flaps
Synonym: Flap, Free
Synonym: Flap, Free Tissue
Synonym: Flap, Microsurgical Free
Synonym: Flaps, Free
Synonym: Flaps, Free Tissue
Synonym: Flaps, Microsurgical Free
Synonym: Free Flap
Synonym: Free Flap, Microsurgical
Synonym: Free Flaps
Synonym: Free Flaps, Microsurgical
Tree Number: T1.3.12.1.1
database_cross_reference: CHV:0000034769
database_cross_reference: MSH:D058752
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X90EK
database_cross_reference: SNOMEDCT_US:261238005

Perforator Flap
type: Class
subclass of: Surgical Flaps
MCID: MC00909496
PMOID: PMO:00000319
Subclass_of: Surgical Flaps
Synonym: Flap, Perforator
Synonym: Flaps, Perforator
Synonym: Perforator Flaps
Tree Number: T1.3.12.1.2
database_cross_reference: MSH:D061525

Myocutaneous Flap
type: Class
subclass of: Surgical Flaps
MCID: MC00150363
PMOID: PMO:00000320
Subclass_of: Surgical Flaps
Synonym: Flap, Musculocutaneous
Synonym: Flap, Myocutaneous
Synonym: Flaps, Musculocutaneous
Synonym: Flaps, Myocutaneous
Synonym: Musculocutaneous Flap
Synonym: Musculocutaneous Flaps
Synonym: Myocutaneous
Synonym: Myocutaneous Flaps
Synonym: Myocutaneous flap
Synonym: Myocutaneous flap (substance)
Tree Number: T1.3.12.1.3
database_cross_reference: CHV:0000035930
database_cross_reference: MSH:D064827
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X90B9
database_cross_reference: SNOMEDCT_US:261138003

Urinary Reservoirs, Continent
type: Class
subclass of: Surgically-Created Structures
MCID: MC00043151
PMOID: PMO:00000321
Subclass_of: Surgically-Created Structures
Synonym: Colonic Urinary Reservoir
Synonym: Colonic Urinary Reservoirs
Synonym: Continent Urinary Reservoir
Synonym: Continent Urinary Reservoirs
Synonym: Reservoir, Colonic Urinary
Synonym: Reservoir, Continent Urinary
Synonym: Reservoirs, Colonic Urinary
Synonym: Reservoirs, Continent Urinary
Synonym: Urinary Reservoir, Colonic
Synonym: Urinary Reservoir, Continent
Tree Number: T1.3.12.2
database_cross_reference: MSH:D016476
database_cross_reference: MTH:NOCODE

Skeletal Muscle Ventricle
type: Class
subclass of: Surgically-Created Structures
PMOID: PMO:00000322
Subclass_of: Surgically-Created Structures
Tree Number: T1.3.12.3

Colonic Pouches
type: Class
subclass of: Surgically-Created Structures
MCID: MC00043803
PMOID: PMO:00000323
Subclass_of: Surgically-Created Structures
Synonym: Colonic Pouche
Synonym: Pelvic Pouches
Synonym: Pouche, Colonic
Synonym: Pouches, Colonic
Synonym: Pouches, Pelvic
Tree Number: T1.3.12.4
database_cross_reference: MSH:D039021

Surgical Stomas
type: Class
subclass of: Surgically-Created Structures
MCID: MC00628685
PMOID: PMO:00000324
Subclass_of: Surgically-Created Structures
Synonym: Stoma
Synonym: Stoma (body structure)
Synonym: Stoma (morphologic abnormality)
Synonym: Stoma site
Synonym: Stoma site (morphologic abnormality)
Synonym: Stoma site, NOS
Synonym: Stoma, NOS
Synonym: Stoma, Surgical
Synonym: Stomas
Synonym: Stomas, Surgical
Tree Number: T1.3.12.5
database_cross_reference: CHV:0000029568
database_cross_reference: LCH_NW:sh85128277
database_cross_reference: MEDLINEPLUS:3038
database_cross_reference: MSH:D054047
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13345
database_cross_reference: NCI_NCI-GLOSS:CDR0000045104
database_cross_reference: RCD:X75Io
database_cross_reference: SNM:M-18800
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:M-18800
database_cross_reference: SNOMEDCT_US:245857005
database_cross_reference: SNOMEDCT_US:91241007

Cell Component
type: Class
subclass of: Anatomical Structure
MCID: MC00081885
PMOID: PMO:00000325
Subclass_of: Anatomical Structure
Synonym: Cell Components
Synonym: Cell Structure
Synonym: Cell component
Synonym: Cellular AND/OR subcellular structure
Synonym: Cellular AND/OR subcellular structure (body structure)
Synonym: Cellular Structure
Synonym: Cellular Structures
Synonym: Cellular structure
Synonym: Cellular structures
Synonym: Component, Cell
Tree Number: T1.4
database_cross_reference: AOD:0000016720
database_cross_reference: CHV:0000025102
database_cross_reference: CSP:0592-6172
database_cross_reference: FMA:86454
database_cross_reference: MSH:D022082
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C14135
database_cross_reference: RCD:Xa0bB
database_cross_reference: SNOMEDCT_US:108351002

Cell Membrane
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
MCID: MC00002445
PMOID: PMO:00000326
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Cell Membranes
Synonym: Cell membrane
Synonym: Cell membrane (body structure)
Synonym: Cell membrane (cell structure)
Synonym: Cell membrane, NOS
Synonym: Cell membranes
Synonym: Cellular membrane
Synonym: Cytoplasmic Membrane
Synonym: Cytoplasmic Membranes
Synonym: Cytoplasmic membrane
Tree Number: T1.4.1
Tree Number: T2.8.1
database_cross_reference: AOD:0000016761
database_cross_reference: AOD:0000027601
database_cross_reference: AOD:0000027603
database_cross_reference: CHV:0000002592
database_cross_reference: CSP:0592-9918
database_cross_reference: FMA:63841
database_cross_reference: GO:GO:0005886
database_cross_reference: GO:GO:0009280
database_cross_reference: LCH:U000871
database_cross_reference: LCH_NW:sh85021654
database_cross_reference: MSH:D002462
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13735
database_cross_reference: NCI_NCI-GLOSS:CDR0000044615
database_cross_reference: SNMI:T-E0200
database_cross_reference: SNOMEDCT_US:53982002
database_cross_reference: UWDA:63841

Erythrocyte Membrane
type: Class
subclass of: Cell Membrane
subclass of: Erythrocytes
MCID: MC00004682
PMOID: PMO:00000327
Subclass_of: Cell Membrane
Subclass_of: Erythrocytes
Synonym: Cytoskeleton, Erythrocyte
Synonym: Cytoskeletons, Erythrocyte
Synonym: Erythrocyte Cytoskeleton
Synonym: Erythrocyte Cytoskeletons
Synonym: Erythrocyte Membranes
Synonym: Erythrocyte membranes
Synonym: Membrane, Erythrocyte
Synonym: Membranes, Erythrocyte
Synonym: erythrocyte membrane
Synonym: erythrocytes membrane
Tree Number: T1.4.1.1
Tree Number: T2.4.2.1
Tree Number: T2.8.1.1
database_cross_reference: CHV:0000004626
database_cross_reference: CSP:1831-7116
database_cross_reference: LCH_NW:sh89006625
database_cross_reference: MSH:D004910

Intracellular Membranes
type: Class
subclass of: Cell Membrane
subclass of: Subcellular Fractions
MCID: MC00006968
PMOID: PMO:00000328
Subclass_of: Cell Membrane
Subclass_of: Subcellular Fractions
Synonym: Intracellular Membrane
Synonym: Intracellular membrane
Synonym: Membrane, Intracellular
Synonym: Membranes, Intracellular
Synonym: Organelle wall
Synonym: Wall of organelle
Synonym: intracellular membrane
Tree Number: T1.4.1.2
Tree Number: T1.4.6.3
Tree Number: T2.8.1.2
Tree Number: T2.8.6.3
database_cross_reference: CSP:0596-3632
database_cross_reference: FMA:85548
database_cross_reference: GO:GO:0031090
database_cross_reference: MSH:D007425
database_cross_reference: NCI:C32876

Nuclear Envelope
type: Class
subclass of: Intracellular Membranes
subclass of: Cell Membrane Structures
MCID: MC00009042
PMOID: PMO:00000329
Subclass_of: Cell Membrane Structures
Subclass_of: Intracellular Membranes
Synonym: Envelope, Nuclear
Synonym: Envelopes, Nuclear
Synonym: Karyotheca
Synonym: Membrane, Nuclear
Synonym: Membranes, Nuclear
Synonym: Nuclear Envelopes
Synonym: Nuclear Membrane
Synonym: Nuclear Membranes
Synonym: Nuclear envelope
Synonym: Nuclear envelope (body structure)
Tree Number: T1.4.1.2.1
Tree Number: T1.4.1.6.4
Tree Number: T1.4.6.3.1
Tree Number: T2.8.1.2.1
Tree Number: T2.8.1.6.4
Tree Number: T2.8.6.3.1
database_cross_reference: AOD:0000016772
database_cross_reference: AOD:0000027605
database_cross_reference: CSP:0597-2997
database_cross_reference: FMA:63888
database_cross_reference: GO:GO:0005635
database_cross_reference: GO:GO:0031965
database_cross_reference: LCH:U003277
database_cross_reference: LCH_NW:sh85093016
database_cross_reference: MSH:D009685
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13265
database_cross_reference: SNM:T-YX050
database_cross_reference: SNMI:T-E0110
database_cross_reference: SNOMEDCT_US:49842008
database_cross_reference: UWDA:63888

Mitochondrial Membranes
type: Class
subclass of: Intracellular Membranes
MCID: MC00182847
PMOID: PMO:00000330
Subclass_of: Intracellular Membranes
Synonym: Membrana mitochondrialis
Synonym: Membrane of mitochondrion
Synonym: Membrane, Mitochondrial
Synonym: Membranes, Mitochondrial
Synonym: Mitochondrial Membrane
Synonym: Mitochondrial membrane
Synonym: Mitochondrial membrane (body structure)
Synonym: Mitochondrial membrane (cell structure)
Synonym: Mitochondrial membranes
Synonym: Mitochondrion membrane
Tree Number: T1.4.1.2.2
Tree Number: T1.4.6.3.2
Tree Number: T2.8.1.2.2
Tree Number: T2.8.6.3.2
database_cross_reference: CSP:0597-1124
database_cross_reference: FMA:66861
database_cross_reference: GO:GO:0031966
database_cross_reference: LCH_NW:sh85086281
database_cross_reference: MSH:D051336
database_cross_reference: NCI:C25937
database_cross_reference: SNOMEDCT_US:312240004
database_cross_reference: UWDA:66861

Sarcolemma
type: Class
subclass of: Cell Membrane
MCID: MC00011596
PMOID: PMO:00000331
Subclass_of: Cell Membrane
Synonym: Plasma membrane of muscle cell
Synonym: Sarcolemma structure
Synonym: Sarcolemma structure (body structure)
Synonym: Sarcolemma structure (cell structure)
Synonym: Sarcolemmas
Synonym: sarcolemma
Tree Number: T1.4.1.3
Tree Number: T2.8.1.3
database_cross_reference: AOD:0000016898
database_cross_reference: CSP:1981-5012
database_cross_reference: FMA:62025
database_cross_reference: GO:GO:0042383
database_cross_reference: LCH:U004212
database_cross_reference: LCH_NW:sh85117503
database_cross_reference: MSH:D012508
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33512
database_cross_reference: SNMI:T-13008
database_cross_reference: SNOMEDCT_US:91740009
database_cross_reference: UWDA:62025

Synaptic Membranes
type: Class
subclass of: Cell Membrane
MCID: MC00012480
PMOID: PMO:00000332
Subclass_of: Cell Membrane
Synonym: Membrane, Synaptic
Synonym: Membranes, Synaptic
Synonym: Synaptic Membrane
Synonym: Synaptic membrane
Synonym: Synaptic membrane (body structure)
Synonym: Synaptic membrane (cell structure)
Synonym: synaptic membrane
Tree Number: T1.4.1.4
Tree Number: T2.8.1.4
database_cross_reference: GO:GO:0097060
database_cross_reference: MSH:D013570
database_cross_reference: SNMI:T-A0382
database_cross_reference: SNOMEDCT_US:81881007

Purple Membrane
type: Class
subclass of: Cell Membrane
MCID: MC00010936
PMOID: PMO:00000333
Subclass_of: Cell Membrane
Synonym: Membrane, Purple
Synonym: Membranes, Purple
Synonym: Purple Membranes
Synonym: bacterial purple membrane
Tree Number: T1.4.1.5
Tree Number: T2.8.1.5
database_cross_reference: CSP:2328-3889
database_cross_reference: MSH:D018717

Cell Membrane Structures
type: Class
subclass of: Cell Membrane
MCID: MC00309995
PMOID: PMO:00000334
Subclass_of: Cell Membrane
Synonym: Cell Membrane Structure
Synonym: Cell membrane structure
Synonym: Cell membrane structure (body structure)
Synonym: Cell membrane structure (cell structure)
Synonym: Membrane Structure, Cell
Synonym: Membrane Structures, Cell
Synonym: Structure, Cell Membrane
Synonym: Structures, Cell Membrane
Synonym: cell membrane structure
Synonym: cell membrane structures
Tree Number: T1.4.1.6
Tree Number: T2.8.1.6
database_cross_reference: CHV:0000052266
database_cross_reference: MSH:D021961
database_cross_reference: SNOMEDCT_US:312241000

Coated Pits, Cell-Membrane
type: Class
subclass of: Cell Membrane Structures
MCID: MC00183420
PMOID: PMO:00000335
Subclass_of: Cell Membrane Structures
Synonym: Bristle Coated Pits
Synonym: Bristle-Coated Pit
Synonym: Bristle-Coated Pits
Synonym: COATED PITS
Synonym: Cell Membrane Coated Pits
Synonym: Cell-Membrane Coated Pit
Synonym: Cell-Membrane Coated Pits
Synonym: Coated Pit
Synonym: Coated Pit, Cell-Membrane
Synonym: Coated Pits, Cell Membrane
Tree Number: T1.4.1.6.1
Tree Number: T2.8.1.6.1
database_cross_reference: CSP:2446-7000
database_cross_reference: CSP:4000-0175
database_cross_reference: MSH:D003034
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13366

Intercellular Junctions
type: Class
subclass of: Cell Membrane Structures
PMOID: PMO:00000337
Subclass_of: Cell Membrane Structures
Tree Number: T1.4.1.6.2
Tree Number: T2.8.1.6.2

Presynaptic Terminals
type: Class
subclass of: Axons
MCID: MC00067332
PMOID: PMO:00000344
Subclass_of: Axons
Synonym: Axon Terminal
Synonym: Axon Terminals
Synonym: Axon terminal
Synonym: Bouton terminal
Synonym: Bouton terminaux
Synonym: Bouton, Synaptic
Synonym: Boutons, Synaptic
Synonym: Ending, Presynaptic Nerve
Synonym: Endings, Presynaptic Nerve
Synonym: Nerve Ending, Presynaptic
Tree Number: T2.23.3.2
Tree Number: T2.23.6.3.3
database_cross_reference: CHV:0000020846
database_cross_reference: FMA:61813
database_cross_reference: GO:GO:0043195
database_cross_reference: MSH:D017729
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33398
database_cross_reference: UWDA:61813

Glycocalyx
type: Class
subclass of: Cell Membrane Structures
MCID: MC00027827
PMOID: PMO:00000352
Subclass_of: Cell Membrane Structures
Synonym: Cell Coat
Synonym: Cell Coats
Synonym: Cell coat
Synonym: Coat, Cell
Synonym: Coats, Cell
Synonym: Fuzzy coat
Synonym: Fuzzy coat of cell
Synonym: Glycocalix
Synonym: Glycocalyx (body structure)
Synonym: Glycocalyx (cell structure)
Tree Number: T1.4.1.6.6
Tree Number: T2.8.1.6.6
database_cross_reference: CHV:0000014114
database_cross_reference: FMA:66838
database_cross_reference: GO:GO:0030112
database_cross_reference: MSH:D019276
database_cross_reference: NCI:C32689
database_cross_reference: SNMI:T-E0280
database_cross_reference: SNOMEDCT_US:19052001
database_cross_reference: UWDA:66838

Membrane Microdomains
type: Class
subclass of: Cell Membrane Structures
MCID: MC00309996
PMOID: PMO:00000353
Subclass_of: Cell Membrane Structures
Synonym: Lipid Rafts, Cell Membrane
Synonym: Membrane Microdomain
Synonym: Microdomain, Membrane
Synonym: Microdomain, Sphingolipid
Synonym: Microdomains, Membrane
Synonym: Microdomains, Sphingolipid
Synonym: Sphingolipid Cholesterol Rafts
Synonym: Sphingolipid Microdomain
Synonym: Sphingolipid Microdomains
Synonym: Sphingolipid-Cholesterol Raft
Tree Number: T1.4.1.6.7
Tree Number: T2.8.1.6.7
database_cross_reference: GO:GO:0098857
database_cross_reference: MSH:D021962

Cell-Matrix Junctions
type: Class
subclass of: Cell Membrane Structures
MCID: MC00309997
PMOID: PMO:00000354
Subclass_of: Cell Membrane Structures
Synonym: Adhesions, Cell-Matrix
Synonym: Cell Attachment
Synonym: Cell Matrix Adhesions
Synonym: Cell Matrix Junctions
Synonym: Cell-Matrix Adhesion Process
Synonym: Cell-Matrix Adhesions
Synonym: Cell-Matrix Junction
Synonym: Cell-matrix adhesions
Synonym: Junction, Cell-Matrix
Synonym: Junctions, Cell-Matrix
Tree Number: T1.4.1.6.8
Tree Number: T2.8.1.6.8
database_cross_reference: GO:GO:0007160
database_cross_reference: GO:GO:0030055
database_cross_reference: LCH_NW:sh2011005720
database_cross_reference: MSH:D021982
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C20191

Phycobilisomes
type: Class
subclass of: Cell Membrane Structures
MCID: MC00054538
PMOID: PMO:00000358
Subclass_of: Cell Membrane Structures
Synonym: Phycobilisome
Synonym: Phycobilisomes [Chemical/Ingredient]
Synonym: phycobilisome
Tree Number: T1.4.1.6.9
Tree Number: T2.8.1.6.9
database_cross_reference: GO:GO:0030089
database_cross_reference: LCH_NW:sh2004010855
database_cross_reference: MSH:D045524
database_cross_reference: NDFRT:N0000167473

Cell Wall
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
MCID: MC00002454
PMOID: PMO:00000359
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Cell Walls
Synonym: Wall, Cell
Synonym: Walls, Cell
Synonym: cell wall
Synonym: cell walls
Tree Number: T1.4.2
Tree Number: T2.8.2
database_cross_reference: CHV:0000002601
database_cross_reference: CSP:0594-1156
database_cross_reference: GO:GO:0005618
database_cross_reference: MSH:D002473

Cell Wall Skeleton
type: Class
subclass of: Cell Wall
subclass of: PMO:00021903
MCID: MC00022573
PMOID: PMO:00000360
Subclass_of: Bacterial Proteins
Subclass_of: Cell Wall
Synonym: Cell Wall Skeleton [Chemical/Ingredient]
Synonym: cell wall skeleton
Tree Number: T1.4.2.1
Tree Number: T2.8.2.1
Tree Number: T6.10.3.10.15
database_cross_reference: MSH:D017358
database_cross_reference: NDDF:009111
database_cross_reference: NDFRT:N0000169173

Inclusion Bodies
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
MCID: MC00002461
PMOID: PMO:00000361
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Bodies, Inclusion
Synonym: Body, Inclusion
Synonym: Cellular Inclusion
Synonym: Cellular Inclusions
Synonym: INCLUSION
Synonym: Inclusion Body
Synonym: Inclusion, Cellular
Synonym: Inclusions
Synonym: Inclusions, Cellular
Synonym: body inclusion
Tree Number: T1.4.3
Tree Number: T2.8.3
database_cross_reference: CHV:0000002605
database_cross_reference: CSP:0602-4404
database_cross_reference: GO:GO:0016234
database_cross_reference: MSH:D002479
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C120945
database_cross_reference: NCI_CDISC:C120945

Erythrocyte Inclusions
type: Class
subclass of: Inclusion Bodies
subclass of: Erythrocytes, Abnormal
MCID: MC00004681
PMOID: PMO:00000362
Subclass_of: Erythrocytes, Abnormal
Subclass_of: Inclusion Bodies
Synonym: Erythrocyte Inclusion
Synonym: Erythrocyte inclusion
Synonym: Erythrocyte inclusion (morphologic abnormality)
Synonym: Inclusion, Erythrocyte
Synonym: Inclusions, Erythrocyte
Tree Number: T1.4.3.1
Tree Number: T2.4.2.2.2
Tree Number: T2.8.3.1
database_cross_reference: MSH:D004908
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:397060004

Heinz Bodies
type: Class
subclass of: Erythrocyte Inclusions
MCID: MC00006003
PMOID: PMO:00000363
Subclass_of: Erythrocyte Inclusions
Synonym: Bodies, Heinz
Synonym: HEINZ BODIES
Synonym: Heinz Body
Synonym: Heinz bodies
Synonym: Heinz body
Synonym: Heinz body (morphologic abnormality)
Synonym: Heinz-Ehrlich body
Synonym: heinz bodies
Synonym: heinz body
Tree Number: T1.4.3.1.1
Tree Number: T2.8.3.1.1
database_cross_reference: CHV:0000005918
database_cross_reference: CST:HEINZ BODIES
database_cross_reference: DXP:U001924
database_cross_reference: LCH:U002118
database_cross_reference: LCH_NW:sh85059964
database_cross_reference: LNC:LP17332-5
database_cross_reference: LNC:MTHU023292
database_cross_reference: MDR:10019372
database_cross_reference: MSH:D006366
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34672
database_cross_reference: SNM:M-78460
database_cross_reference: SNMI:M-63420
database_cross_reference: SNOMEDCT_US:42222008

Inclusion Bodies, Viral
type: Class
subclass of: Inclusion Bodies
MCID: MC00006786
PMOID: PMO:00000364
Subclass_of: Inclusion Bodies
Synonym: Bodies, Viral Inclusion
Synonym: Body, Viral Inclusion
Synonym: Inclusion Body, Viral
Synonym: Viral Inclusion Bodies
Synonym: Viral Inclusion Body
Synonym: Viral inclusion bodies
Synonym: Viral inclusion body
Synonym: Viral inclusion body (morphologic abnormality)
Synonym: Viral inclusion body, NOS
Tree Number: T1.4.3.2
Tree Number: T2.8.3.2
database_cross_reference: LNC:LP15190-9
database_cross_reference: LNC:MTHU002585
database_cross_reference: MSH:D007181
database_cross_reference: SNMI:M-62800
database_cross_reference: SNOMEDCT_US:53012008

Lewy Bodies
type: Class
subclass of: Inclusion Bodies
subclass of: Neurons
MCID: MC00043203
PMOID: PMO:00000365
Subclass_of: Inclusion Bodies
Subclass_of: Neurons
Synonym: Bodies, Lewy
Synonym: Body, Lewy
Synonym: Lewy Body
Synonym: Lewy bodies
Synonym: Lewy bodies (morphologic abnormality)
Synonym: Lewy body
Synonym: bodies lewi
Synonym: bodies lewis
Synonym: bodies lewy
Synonym: body lewi
Tree Number: T1.4.3.3
Tree Number: T2.23.14
Tree Number: T2.8.3.3
database_cross_reference: CHV:0000015490
database_cross_reference: CSP:4006-0057
database_cross_reference: GO:GO:0097413
database_cross_reference: HPO:HP:0100315
database_cross_reference: MSH:D016631
database_cross_reference: OMIM:MTHU035458
database_cross_reference: SNM:M-66700
database_cross_reference: SNMI:M-62678
database_cross_reference: SNOMEDCT_US:43127003

Intranuclear Inclusion Bodies
type: Class
subclass of: Inclusion Bodies
MCID: MC00466773
PMOID: PMO:00000366
Subclass_of: Inclusion Bodies
Synonym: Inclusion Bodies, Intranuclear
Synonym: Inclusion Bodies, Nuclear
Synonym: Inclusion Body, Intranuclear
Synonym: Inclusion Body, Nuclear
Synonym: Inclusion, Intranuclear
Synonym: Inclusion, Nuclear
Synonym: Inclusions, Intranuclear
Synonym: Inclusions, Nuclear
Synonym: Intranuclear Inclusion
Synonym: Intranuclear Inclusion Body
Tree Number: T1.4.3.4
Tree Number: T2.8.3.4
database_cross_reference: FMA:67221
database_cross_reference: GO:GO:0042405
database_cross_reference: MSH:D045586
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C36017
database_cross_reference: SNM:M-65500
database_cross_reference: SNMI:T-E0180
database_cross_reference: SNOMEDCT_US:13698008
database_cross_reference: SNOMEDCT_VET:312791000009106
database_cross_reference: UWDA:67221

Mallory Bodies
type: Class
subclass of: Inclusion Bodies
PMOID: PMO:00000367
Subclass_of: Inclusion Bodies
Tree Number: T1.4.3.5
Tree Number: T2.8.3.5

Chromosomes
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
MCID: MC00002831
PMOID: PMO:00000368
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: CHROMOSOME
Synonym: Chromosomal
Synonym: Chromosome
Synonym: Chromosome (body structure)
Synonym: Chromosome (cell structure)
Synonym: Chromosome, NOS
Synonym: chromosome
Synonym: chromosomes
Tree Number: T1.4.4
Tree Number: T2.8.4
database_cross_reference: AOD:0000002907
database_cross_reference: CCPSS:0059984
database_cross_reference: CHV:0000002946
database_cross_reference: CSP:1255-7932
database_cross_reference: FMA:67093
database_cross_reference: GO:GO:0005694
database_cross_reference: LCH:U001014
database_cross_reference: LCH_NW:sh85025391
database_cross_reference: LNC:LP20948-3
database_cross_reference: LNC:LP32750-9
database_cross_reference: LNC:MTHU047638
database_cross_reference: MSH:D002875
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13202
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046470
database_cross_reference: PSY:09170
database_cross_reference: RCD:Xa0dt
database_cross_reference: SNM:T-YX100
database_cross_reference: SNM:U000526
database_cross_reference: SNMI:T-E0130
database_cross_reference: SNOMEDCT_US:91272006
database_cross_reference: UWDA:67093

Chromosomes, Bacterial
type: Class
subclass of: Chromosomes
MCID: MC00002832
PMOID: PMO:00000369
Subclass_of: Chromosomes
Synonym: BACT CHROMOSOME
Synonym: BACT CHROMOSOMES
Synonym: Bacterial Chromosome
Synonym: Bacterial Chromosomes
Synonym: Bacterial chromosomes
Synonym: CHROMOSOME BACT
Synonym: CHROMOSOMES BACT
Synonym: Chromosome, Bacterial
Tree Number: T1.4.4.1
Tree Number: T2.8.4.1
database_cross_reference: LCH_NW:sh89006409
database_cross_reference: MSH:D002876

Chromosomes, Artificial, Bacterial
type: Class
subclass of: Chromosomes, Bacterial
subclass of: Chromosomes, Artificial
PMOID: PMO:00000370
Subclass_of: Chromosomes, Artificial
Subclass_of: Chromosomes, Bacterial
Tree Number: T1.4.4.1.1
Tree Number: T1.4.4.7.2
Tree Number: T2.8.4.1.1
Tree Number: T2.8.4.7.2

Ring Chromosomes
type: Class
subclass of: Chromosomes
MCID: MC00011418
PMOID: PMO:00000371
Subclass_of: Chromosomes
Synonym: Chromosome, Ring
Synonym: Chromosomes, Ring
Synonym: Ring Chromosome
Synonym: Ring Chromosomes [Disease/Finding]
Synonym: Ring chromosome
Synonym: Ring chromosome (morphologic abnormality)
Synonym: Supernumerary Circular Chromosome
Synonym: chromosome ring
Synonym: r
Synonym: ring chromosome
Tree Number: T1.4.4.2
Tree Number: T2.8.4.2
database_cross_reference: CHV:0000010907
database_cross_reference: MSH:D012303
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3360
database_cross_reference: NDFRT:N0000002649
database_cross_reference: SNM:M-63330
database_cross_reference: SNMI:M-61280
database_cross_reference: SNOMEDCT_US:23345003

Sex Chromosomes
type: Class
subclass of: Chromosomes
MCID: MC00011798
PMOID: PMO:00000372
Subclass_of: Chromosomes
Synonym: Chromosome, Sex
Synonym: Chromosomes, Sex
Synonym: Gonosome
Synonym: Gonosomes
Synonym: Sex Chromosome
Synonym: Sex chromosome
Synonym: Sex chromosome (body structure)
Synonym: Sex chromosome (cell structure)
Synonym: Sex chromosome structure
Synonym: Sex chromosome structure (body structure)
Tree Number: T1.4.4.3
Tree Number: T2.8.4.3
database_cross_reference: CHV:0000011264
database_cross_reference: CSP:1256-1296
database_cross_reference: FMA:74407
database_cross_reference: GO:GO:0000803
database_cross_reference: LCH:U004282
database_cross_reference: LCH_NW:sh85120570
database_cross_reference: MSH:D012730
database_cross_reference: NCI:C33542
database_cross_reference: PSY:46840
database_cross_reference: SNM:T-YX123
database_cross_reference: SNMI:T-E0159
database_cross_reference: SNOMEDCT_US:312238009
database_cross_reference: SNOMEDCT_US:32247007
database_cross_reference: UWDA:74407

Pseudoautosomal Regions
type: Class
subclass of: Sex Chromosomes
MCID: MC00525043
PMOID: PMO:00000373
Subclass_of: Sex Chromosomes
Synonym: Pseudoautosomal Region
Tree Number: T1.4.4.3.1
Tree Number: T2.8.4.3.1
database_cross_reference: MSH:D000071439
database_cross_reference: NCI:C42296

Sex Chromatin
type: Class
subclass of: Sex Chromosomes
MCID: MC00011796
PMOID: PMO:00000374
Subclass_of: Sex Chromosomes
Synonym: Barr Bodies
Synonym: Barr Body
Synonym: Barr bodies
Synonym: Barr body
Synonym: Barr chromatin body
Synonym: Bodies, Barr
Synonym: Chromatin, Sex
Synonym: Chromatins, Sex
Synonym: Sex Chromatins
Synonym: Sex chromatin
Tree Number: T1.4.4.3.2
Tree Number: T2.8.4.3.2
database_cross_reference: CHV:0000011262
database_cross_reference: FMA:84718
database_cross_reference: GO:GO:0001739
database_cross_reference: GO:GO:0001740
database_cross_reference: LCH:U004280
database_cross_reference: LCH_NW:sh85120567
database_cross_reference: LNC:LA11179-1
database_cross_reference: LNC:LP18339-9
database_cross_reference: LNC:MTHU004078
database_cross_reference: MSH:D012728
database_cross_reference: NCI:C32182
database_cross_reference: SNM:T-YX074
database_cross_reference: SNMI:T-E0126
database_cross_reference: SNOMEDCT_US:58348001

X Chromosome
type: Class
subclass of: Sex Chromosomes
MCID: MC00013743
PMOID: PMO:00000375
Subclass_of: Sex Chromosomes
Synonym: Chromosome X
Synonym: Chromosome, X
Synonym: Chromosomes, X
Synonym: Female sex chromosome
Synonym: Sex chromosome X
Synonym: Sex chromosome X (body structure)
Synonym: Sex chromosome X (cell structure)
Synonym: X Chromosomes
Synonym: X chromosome
Synonym: chromosome x
Tree Number: T1.4.4.3.3
Tree Number: T2.8.4.3.3
database_cross_reference: CHV:0000013214
database_cross_reference: CSP:1256-1296
database_cross_reference: FMA:84055
database_cross_reference: GO:GO:0000805
database_cross_reference: LCH:U005052
database_cross_reference: LCH_NW:sh85148724
database_cross_reference: LNC:LA21276-3
database_cross_reference: MSH:D014960
database_cross_reference: NCI:C13285
database_cross_reference: SNM:T-YX12X
database_cross_reference: SNMI:T-E015A
database_cross_reference: SNOMEDCT_US:72837006

Y Chromosome
type: Class
subclass of: Sex Chromosomes
MCID: MC00013778
PMOID: PMO:00000377
Subclass_of: Sex Chromosomes
Synonym: Chromosome Y
Synonym: Chromosome, Y
Synonym: Chromosomes, Y
Synonym: Male sex chromosome
Synonym: Sex chromosome Y
Synonym: Sex chromosome Y (body structure)
Synonym: Sex chromosome Y (cell structure)
Synonym: Y Chromosomes
Synonym: Y chromosome
Synonym: chromosome male sex
Tree Number: T1.4.4.3.4
Tree Number: T2.8.4.3.4
database_cross_reference: CHV:0000013245
database_cross_reference: CSP:1256-1296
database_cross_reference: FMA:84056
database_cross_reference: GO:GO:0000806
database_cross_reference: LCH:U005067
database_cross_reference: LCH_NW:sh85148874
database_cross_reference: LNC:LA21277-1
database_cross_reference: LNC:LP33230-1
database_cross_reference: LNC:MTHU048884
database_cross_reference: MSH:D014998
database_cross_reference: NCI:C13286
database_cross_reference: SNM:T-YX12Y
database_cross_reference: SNMI:T-E015B
database_cross_reference: SNOMEDCT_US:5421003

Chromosomes, Fungal
type: Class
subclass of: Chromosomes
MCID: MC00002833
PMOID: PMO:00000379
Subclass_of: Chromosomes
Synonym: Chromosome, Fungal
Synonym: Fungal Chromosome
Synonym: Fungal Chromosomes
Tree Number: T1.4.4.4
Tree Number: T2.8.4.4
database_cross_reference: MSH:D015825

Chromosomes, Artificial, Yeast
type: Class
subclass of: Chromosomes, Fungal
subclass of: Chromosomes, Artificial
PMOID: PMO:00000380
Subclass_of: Chromosomes, Artificial
Subclass_of: Chromosomes, Fungal
Tree Number: T1.4.4.4.1
Tree Number: T1.4.4.7.1
Tree Number: T2.8.4.4.1
Tree Number: T2.8.4.7.1

Isochromosomes
type: Class
subclass of: Chromosomes
MCID: MC00081710
PMOID: PMO:00000381
Subclass_of: Chromosomes
Synonym: Isochromosome
Synonym: Isochromosomes [Disease/Finding]
Synonym: isochromosome
Tree Number: T1.4.4.5
Tree Number: T2.8.4.5
database_cross_reference: CHV:0000024890
database_cross_reference: MSH:D018404
database_cross_reference: NCI:C3897
database_cross_reference: NDFRT:N0000003810

Chromosomes, Archaeal
type: Class
subclass of: Chromosomes
MCID: MC00163977
PMOID: PMO:00000382
Subclass_of: Chromosomes
Synonym: Archaeal Chromosome
Synonym: Archaeal Chromosomes
Synonym: Chromosome, Archaeal
Tree Number: T1.4.4.6
Tree Number: T2.8.4.6
database_cross_reference: MSH:D019847

Chromosomes, Artificial
type: Class
subclass of: Chromosomes
PMOID: PMO:00000383
Subclass_of: Chromosomes
Tree Number: T1.4.4.7
Tree Number: T2.8.4.7

Chromosomes, Artificial, Mammalian
type: Class
subclass of: Chromosomes, Artificial
subclass of: Chromosomes, Mammalian
PMOID: PMO:00000384
Subclass_of: Chromosomes, Artificial
Subclass_of: Chromosomes, Mammalian
Tree Number: T1.4.4.7.3
Tree Number: T1.4.4.9.2
Tree Number: T2.8.4.7.3
Tree Number: T2.8.4.9.2

Chromosomes, Artificial, P1 Bacteriophage
type: Class
subclass of: Chromosomes, Artificial
PMOID: PMO:00000386
Subclass_of: Chromosomes, Artificial
Tree Number: T1.4.4.7.4
Tree Number: T2.8.4.7.4

Chromosomes, Plant
type: Class
subclass of: Chromosomes
PMOID: PMO:00000387
Subclass_of: Chromosomes
Tree Number: T1.4.4.8
Tree Number: T2.8.4.8

Chromosomes, Mammalian
type: Class
subclass of: Chromosomes
MCID: MC00377771
PMOID: PMO:00000388
Subclass_of: Chromosomes
Synonym: Chromosome, Mammalian
Synonym: Mammalian Chromosome
Synonym: Mammalian Chromosomes
Tree Number: T1.4.4.9
Tree Number: T2.8.4.9
database_cross_reference: MSH:D033481

Chromosomes, Human
type: Class
subclass of: Chromosomes, Mammalian
MCID: MC00002834
PMOID: PMO:00000389
Subclass_of: Chromosomes, Mammalian
Synonym: Chromosome, Human
Synonym: Human Chromosome
Synonym: Human Chromosomes
Synonym: Human chromosomes
Synonym: human chromosome
Synonym: human chromosomes
Tree Number: T1.4.4.9.1
Tree Number: T2.8.4.9.1
database_cross_reference: CHV:0000002947
database_cross_reference: LCH_NW:sh85062851
database_cross_reference: MSH:D002877
database_cross_reference: NCI:C13203

Chromosomes, Insect
type: Class
subclass of: Chromosomes
PMOID: PMO:00000420
Subclass_of: Chromosomes
Tree Number: T1.4.4.10
Tree Number: T2.8.4.10

Polytene Chromosomes
type: Class
subclass of: Chromosomes, Insect
MCID: MC00394745
PMOID: PMO:00000421
Subclass_of: Chromosomes, Insect
Synonym: Chromosome, Polytene
Synonym: Chromosomes, Polytene
Synonym: Polytene Chromosome
Synonym: polytene chromosome
Tree Number: T1.4.4.10.1
Tree Number: T2.8.4.10.1
database_cross_reference: GO:GO:0005700
database_cross_reference: MSH:D059007

Extracellular Vesicles
type: Class
subclass of: Extracellular Space
MCID: MC00993538
PMOID: PMO:00000422
Subclass_of: Extracellular Space
Synonym: Extracellular Vesicle
Synonym: Vesicle, Extracellular
Synonym: Vesicles, Extracellular
Synonym: extracellular vesicle
Tree Number: T1.4.5.1
Tree Number: T2.8.5.1
database_cross_reference: GO:GO:1903561
database_cross_reference: MSH:D000067128

Cell-Derived Microparticles
type: Class
subclass of: Extracellular Vesicles
MCID: MC00715385
PMOID: PMO:00000423
Subclass_of: Extracellular Vesicles
Synonym: Cell Derived Microparticles
Synonym: Cell Membrane Microparticle
Synonym: Cell Membrane Microparticles
Synonym: Cell-Derived Microparticle
Synonym: Circulating Microparticle
Synonym: Circulating Microvesicle
Synonym: Ectosome
Synonym: Ectosomes
Synonym: Membrane Microparticle, Cell
Synonym: Membrane Microparticles, Cell
Tree Number: T1.4.5.1.1
Tree Number: T2.8.5.1.1
database_cross_reference: GO:GO:1990742
database_cross_reference: MSH:D055252
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C120025

Exosomes
type: Class
subclass of: Extracellular Vesicles
MCID: MC00715406
PMOID: PMO:00000424
Subclass_of: Extracellular Vesicles
Synonym: Exosome
Synonym: exosome
Synonym: extracellular exosome
Synonym: extracellular vesicular exosome
Tree Number: T1.4.5.1.2
Tree Number: T2.8.5.1.2
database_cross_reference: GO:GO:0070062
database_cross_reference: MSH:D055354
database_cross_reference: NCI:C104457

Extracellular Matrix
type: Class
subclass of: Extracellular Space
MCID: MC00004880
PMOID: PMO:00000425
Subclass_of: Extracellular Space
Synonym: Cell-Extracellular Matrix
Synonym: ECM
Synonym: Extracellular Matrices
Synonym: Extracellular matrix
Synonym: ICM
Synonym: Intercellular matrix
Synonym: Matrices, Extracellular
Synonym: Matrix, Extracellular
Synonym: Portion of extracellular matrix
Synonym: ecm
Tree Number: T1.4.5.2
Tree Number: T2.8.5.2
database_cross_reference: CHV:0000004796
database_cross_reference: CSP:0595-5294
database_cross_reference: FMA:9672
database_cross_reference: GO:GO:0031012
database_cross_reference: LCH:U001709
database_cross_reference: LCH_NW:sh85057464
database_cross_reference: MSH:D005109
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13232
database_cross_reference: UWDA:9672

Microfibrils
type: Class
subclass of: Extracellular Matrix
MCID: MC00259301
PMOID: PMO:00000426
Subclass_of: Extracellular Matrix
Synonym: Microfibril
Synonym: extended fibrils
Synonym: microfibril
Tree Number: T1.4.5.2.2
Tree Number: T2.8.5.2.2
database_cross_reference: GO:GO:0001527
database_cross_reference: MSH:D020894

Periplasm
type: Class
subclass of: Extracellular Space
MCID: MC00164008
PMOID: PMO:00000427
Subclass_of: Extracellular Space
Synonym: Periplasmic Space
Synonym: Periplasmic Spaces
Synonym: Periplasms
Synonym: Space, Periplasmic
Synonym: Spaces, Periplasmic
Synonym: periplasm
Synonym: periplasmic
Synonym: periplasmic space
Tree Number: T1.4.5.3
Tree Number: T2.8.5.3
database_cross_reference: CHV:0000038387
database_cross_reference: CSP:4008-0076
database_cross_reference: GO:GO:0042597
database_cross_reference: MSH:D019897
database_cross_reference: MTH:NOCODE

Extracellular Fluid
type: Class
subclass of: Extracellular Space
MCID: MC00004879
PMOID: PMO:00000428
Subclass_of: Extracellular Space
Synonym: Extracellular Fluids
Synonym: Extracellular fluid
Synonym: Extracellular fluid (substance)
Synonym: Fluid, Extracellular
Synonym: Fluids, Extracellular
Synonym: extracellular fluid
Synonym: extracellular fluids
Tree Number: T1.4.5.4
Tree Number: T2.8.5.4
database_cross_reference: CHV:0000004795
database_cross_reference: LCH_NW:sh85046576
database_cross_reference: LNC:LP172617-5
database_cross_reference: LNC:MTHU046292
database_cross_reference: MSH:D045604
database_cross_reference: SNM:T-00080
database_cross_reference: SNMI:T-D0071
database_cross_reference: SNOMEDCT_US:55450009

Extracellular Traps
type: Class
subclass of: Extracellular Space
MCID: MC00976488
PMOID: PMO:00000429
Subclass_of: Extracellular Space
Synonym: DNA Trap, Extracellular
Synonym: DNA Traps, Extracellular
Synonym: Extracellular DNA Trap
Synonym: Extracellular DNA Traps
Synonym: Extracellular Trap
Synonym: Trap, Extracellular
Synonym: Trap, Extracellular DNA
Synonym: Traps, Extracellular
Synonym: Traps, Extracellular DNA
Tree Number: T1.4.5.5
Tree Number: T2.8.5.5
database_cross_reference: MSH:D065206

Subcellular Fractions
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
MCID: MC00012300
PMOID: PMO:00000430
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Fraction, Subcellular
Synonym: Fractions, Subcellular
Synonym: Subcellular Fraction
Synonym: Subcellular structure, isolated by fractionation technique
Synonym: Subcellular structure, isolated by fractionation technique (body structure)
Synonym: Subcellular structure, isolated by fractionation technique (cell structure)
Tree Number: T1.4.6
Tree Number: T2.8.6
database_cross_reference: MSH:D013347
database_cross_reference: SNMI:T-E0002
database_cross_reference: SNOMEDCT_US:90503007

Cell-Free System
type: Class
subclass of: Subcellular Fractions
MCID: MC00002455
PMOID: PMO:00000431
Subclass_of: Subcellular Fractions
Synonym: Cell Free System
Synonym: Cell-Free Systems
Synonym: Cell-free System
Synonym: Cellfree System
Synonym: Cellfree Systems
Synonym: System, Cell-Free
Synonym: System, Cellfree
Synonym: Systems, Cell-Free
Synonym: Systems, Cellfree
Synonym: cell free system
Tree Number: T1.4.6.1
Tree Number: T2.8.6.1
database_cross_reference: CSP:0602-1695
database_cross_reference: MSH:D002474
database_cross_reference: NCI:C15201

Intracellular Fluid
type: Class
subclass of: Intracellular Space
subclass of: Subcellular Fractions
MCID: MC00006967
PMOID: PMO:00000432
Subclass_of: Intracellular Space
Subclass_of: Subcellular Fractions
Synonym: Fluid, Intracellular
Synonym: Fluids, Intracellular
Synonym: Intracellular Fluids
Synonym: Intracellular fluid
Synonym: Intracellular fluid (substance)
Synonym: intracellular fluid
Synonym: intracellular fluids
Tree Number: T1.4.6.2
Tree Number: T1.4.8.3
Tree Number: T2.8.6.2
Tree Number: T2.8.8.3
database_cross_reference: CHV:0000006869
database_cross_reference: LNC:LP172618-3
database_cross_reference: LNC:MTHU046291
database_cross_reference: MSH:D007424
database_cross_reference: SNM:T-00090
database_cross_reference: SNMI:T-D0072
database_cross_reference: SNOMEDCT_US:20125000

Cytosol
type: Class
subclass of: Intracellular Fluid
subclass of: Cytoplasm
MCID: MC00473910
PMOID: PMO:00000433
Subclass_of: Cytoplasm
Subclass_of: Intracellular Fluid
Synonym: Cell Matrix
Synonym: Cytomatrix
Synonym: Cytoplasmic Matrix
Synonym: Cytoplasmic matrix
Synonym: Cytoplasmic matrix (body structure)
Synonym: Cytoplasmic matrix (cell structure)
Synonym: Cytoplasmic matrix, NOS
Synonym: Cytosolic
Synonym: Cytosols
Synonym: Hyaloplasm
Tree Number: T1.4.6.2.1
Tree Number: T1.4.8.2.1
Tree Number: T1.4.8.3.1
Tree Number: T2.8.6.2.1
Tree Number: T2.8.8.2.1
Tree Number: T2.8.8.3.1
database_cross_reference: AOD:0000027598
database_cross_reference: CHV:0000003594
database_cross_reference: CSP:0595-2394
database_cross_reference: FMA:66836
database_cross_reference: GO:GO:0005829
database_cross_reference: LCH:U001264
database_cross_reference: LCH_NW:sh85035257
database_cross_reference: MSH:D003600
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32424
database_cross_reference: NCI:C61554
database_cross_reference: SNMI:T-E0300
database_cross_reference: SNOMEDCT_US:62035001
database_cross_reference: UWDA:66836

Microsomes
type: Class
subclass of: Subcellular Fractions
MCID: MC00008293
PMOID: PMO:00000434
Subclass_of: Subcellular Fractions
Synonym: Endoplasmic reticulum vesicle
Synonym: Microsome
Synonym: microsome
Synonym: microsomes
Synonym: obsolete microsome
Tree Number: T1.4.6.4
Tree Number: T2.8.6.4
database_cross_reference: AOD:0000016733
database_cross_reference: CHV:0000008113
database_cross_reference: CSP:0596-7378
database_cross_reference: FMA:67438
database_cross_reference: GO:GO:0005792
database_cross_reference: LCH:U002970
database_cross_reference: LCH_NW:sh85084921
database_cross_reference: MSH:D008861
database_cross_reference: UWDA:67438

Microsomes, Liver
type: Class
subclass of: Microsomes
MCID: MC00008294
PMOID: PMO:00000435
Subclass_of: Microsomes
Synonym: Liver Microsome
Synonym: Liver Microsomes
Synonym: Microsome, Liver
Tree Number: T1.4.6.4.1
Tree Number: T2.8.6.4.1
database_cross_reference: MSH:D008862

Mitochondria
type: Class
subclass of: Subcellular Fractions
MCID: MC00008343
PMOID: PMO:00000436
Subclass_of: Subcellular Fractions
Synonym: Mitochondrial
Synonym: Mitochondrial structure
Synonym: Mitochondrial structure (body structure)
Synonym: Mitochondrial structure (cell structure)
Synonym: Mitochondrion
Synonym: Mitochondrion (body structure)
Synonym: Mitochondrion (cell structure)
Synonym: Mitochondrion, NOS
Synonym: mitochondria
Synonym: mitochondrial
Tree Number: T1.4.6.5
Tree Number: T2.8.6.5
database_cross_reference: AOD:0000016737
database_cross_reference: AOD:0000027597
database_cross_reference: CHV:0000008181
database_cross_reference: CHV:0000037962
database_cross_reference: CSP:0596-9251
database_cross_reference: FMA:63835
database_cross_reference: GO:GO:0005739
database_cross_reference: LCH:U002998
database_cross_reference: LCH_NW:sh85086280
database_cross_reference: LNC:LP16724-4
database_cross_reference: MSH:D008928
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13258
database_cross_reference: NCI_NCI-GLOSS:CDR0000044060
database_cross_reference: SNMI:T-E0700
database_cross_reference: SNOMEDCT_US:312239001
database_cross_reference: SNOMEDCT_US:75056005
database_cross_reference: UWDA:63835

Mitochondria, Liver
type: Class
subclass of: Mitochondria
MCID: MC00008345
PMOID: PMO:00000437
Subclass_of: Mitochondria
Synonym: Liver Mitochondria
Synonym: Liver Mitochondrion
Synonym: Mitochondrion, Liver
Tree Number: T1.4.6.5.1
Tree Number: T2.8.6.5.1
database_cross_reference: MSH:D008930

Mitochondria, Muscle
type: Class
subclass of: Mitochondria
MCID: MC00008346
PMOID: PMO:00000438
Subclass_of: Mitochondria
Synonym: Mitochondrion, Muscle
Synonym: Muscle Mitochondria
Synonym: Muscle Mitochondrion
Synonym: Sarcosome
Synonym: Sarcosomes
Synonym: mitochondria muscles
Synonym: muscle mitochondria
Tree Number: T1.4.6.5.2
Tree Number: T2.8.6.5.2
database_cross_reference: CHV:0000008182
database_cross_reference: MSH:D008931

Submitochondrial Particles
type: Class
subclass of: Mitochondria
MCID: MC00012317
PMOID: PMO:00000440
Subclass_of: Mitochondria
Synonym: Particle, Submitochondrial
Synonym: Particles, Submitochondrial
Synonym: Submitochondrial Particle
Tree Number: T1.4.6.5.3
Tree Number: T2.8.6.5.3
database_cross_reference: MSH:D013367

Synaptosomes
type: Class
subclass of: Subcellular Fractions
MCID: MC00012484
PMOID: PMO:00000441
Subclass_of: Subcellular Fractions
Synonym: Synaptosome
Synonym: obsolete synaptosome
Synonym: synaptoneurosome
Synonym: synaptosome
Synonym: synaptosomes
Tree Number: T1.4.6.6
Tree Number: T2.8.6.6
database_cross_reference: AOD:0000017693
database_cross_reference: CHV:0000011974
database_cross_reference: CSP:2047-3223
database_cross_reference: GO:GO:0019717
database_cross_reference: LCH:U004559
database_cross_reference: LCH_NW:sh85131594
database_cross_reference: MSH:D013574

Cell Surface Extensions
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
MCID: MC00310003
PMOID: PMO:00000442
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Cell Membrane Extension
Synonym: Cell Membrane Extensions
Synonym: Cell Membrane Projection
Synonym: Cell Membrane Projections
Synonym: Cell Membrane Protrusion
Synonym: Cell Membrane Protrusions
Synonym: Cell Surface Extension
Synonym: Cell Surface Projection
Synonym: Cell Surface Projections
Synonym: Cell Surface Protrusion
Tree Number: T1.4.7
Tree Number: T2.8.7
database_cross_reference: GO:GO:0031253
database_cross_reference: MSH:D022081
database_cross_reference: NCI:C26114

Telopodes
type: Class
subclass of: Cell Surface Extensions
subclass of: Telocytes
MCID: MC01007839
PMOID: PMO:00000443
Subclass_of: Cell Surface Extensions
Subclass_of: Telocytes
Synonym: Telopode
Tree Number: T1.4.7.1
Tree Number: T2.10.9.1.1
Tree Number: T2.8.7.1
database_cross_reference: MSH:D000067617

Podosomes
type: Class
subclass of: Cell Surface Extensions
subclass of: Endothelial Cells
MCID: MC00691762
PMOID: PMO:00000444
Subclass_of: Cell Surface Extensions
Subclass_of: Endothelial Cells
Synonym: Invadopodia
Synonym: Invadopodium
Synonym: Invadopodiums
Synonym: Invadosome
Synonym: Invadosomes
Synonym: Podosome
Synonym: invadopodium
Synonym: podosome
Tree Number: T1.4.7.2
Tree Number: T2.12.27.1
Tree Number: T2.8.7.2
database_cross_reference: GO:GO:0002102
database_cross_reference: GO:GO:0071437
database_cross_reference: MSH:D000069261

Axons
type: Class
subclass of: Cell Surface Extensions
subclass of: Neurons
subclass of: Nerve Fibers
MCID: MC00001421
PMOID: PMO:00000445
Subclass_of: Cell Surface Extensions
Subclass_of: Nerve Fibers
Subclass_of: Neurons
Synonym: Axon
Synonym: Axon structure
Synonym: Axon structure (body structure)
Synonym: Axon structure (cell structure)
Synonym: axon
Synonym: axone
Synonym: axons
Synonym: neuraxon
Synonym: neuraxons
Tree Number: T1.4.7.3
Tree Number: T2.23.3
Tree Number: T2.23.6.3
Tree Number: T2.8.7.3
database_cross_reference: AOD:0000017681
database_cross_reference: AOD:0000027991
database_cross_reference: AOD:0000027993
database_cross_reference: CHV:0000001632
database_cross_reference: CSP:2047-3613
database_cross_reference: FMA:67308
database_cross_reference: GO:GO:0030424
database_cross_reference: LCH:U000457
database_cross_reference: LCH_NW:sh85010598
database_cross_reference: MSH:D001369
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32177
database_cross_reference: PSY:05220
database_cross_reference: SNM:T-X0280
database_cross_reference: SNMI:T-A0280
database_cross_reference: SNOMEDCT_US:60436000
database_cross_reference: UWDA:67308

Axon Initial Segment
type: Class
subclass of: Axons
MCID: MC00403456
PMOID: PMO:00000446
Subclass_of: Axons
Synonym: Axon Initial Segments
Synonym: Initial segment of axon
Synonym: axon initial segment
Synonym: initial segment
Tree Number: T1.4.7.3.1
Tree Number: T2.23.3.1
Tree Number: T2.23.6.3.1
Tree Number: T2.8.7.3.1
database_cross_reference: FMA:67382
database_cross_reference: GO:GO:0043194
database_cross_reference: MSH:D000071040
database_cross_reference: UWDA:67382

Growth Cones
type: Class
subclass of: Axons
subclass of: Dendrites
subclass of: Neurites
MCID: MC00182705
PMOID: PMO:00000447
Subclass_of: Axons
Subclass_of: Dendrites
Subclass_of: Neurites
Synonym: Growth Cone
Synonym: growth cone
Tree Number: T1.4.7.10.1
Tree Number: T1.4.7.3.2
Tree Number: T1.4.7.5.1
Tree Number: T2.23.3.4
Tree Number: T2.23.4.1
Tree Number: T2.8.7.10.1
Tree Number: T2.8.7.3.2
Tree Number: T2.8.7.5.1
database_cross_reference: CSP:2047-3450
database_cross_reference: GO:GO:0030426
database_cross_reference: MSH:D020439

Cilia
type: Class
subclass of: Cell Surface Extensions
MCID: MC00002904
PMOID: PMO:00000448
Subclass_of: Cell Surface Extensions
Synonym: Cilium
Synonym: Cilium (body structure)
Synonym: Cilium (cell structure)
Synonym: Cilium, NOS
Synonym: cilia
Synonym: cilium
Synonym: eukaryotic flagellum
Synonym: microtubule-based flagellum
Tree Number: T1.4.7.4
Tree Number: T2.8.7.4
database_cross_reference: AOD:0000016766
database_cross_reference: CHV:0000002990
database_cross_reference: CSP:0594-8648
database_cross_reference: FMA:67181
database_cross_reference: GO:GO:0005929
database_cross_reference: GO:GO:0031514
database_cross_reference: MSH:D002923
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32318
database_cross_reference: SNMI:T-E0460
database_cross_reference: SNOMEDCT_US:69315009
database_cross_reference: UWDA:67181

Dendrites
type: Class
subclass of: Cell Surface Extensions
subclass of: Neurons
MCID: MC00003619
PMOID: PMO:00000449
Subclass_of: Cell Surface Extensions
Subclass_of: Neurons
Synonym: Dendrite
Synonym: Dendrite (body structure)
Synonym: Dendrite (cell structure)
Synonym: Dendritic
Synonym: dendrite
Synonym: dendrites
Tree Number: T1.4.7.5
Tree Number: T2.23.4
Tree Number: T2.8.7.5
database_cross_reference: AOD:0000017680
database_cross_reference: CHV:0000003694
database_cross_reference: CSP:2047-3635
database_cross_reference: FMA:67314
database_cross_reference: GO:GO:0030425
database_cross_reference: LCH:U001294
database_cross_reference: LCH_NW:sh85036698
database_cross_reference: MSH:D003712
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32447
database_cross_reference: PSY:13490
database_cross_reference: SNM:T-X0270
database_cross_reference: SNMI:T-A0270
database_cross_reference: SNOMEDCT_US:90604005
database_cross_reference: UWDA:67314

Dendritic Spines
type: Class
subclass of: Dendrites
MCID: MC00304869
PMOID: PMO:00000450
Subclass_of: Dendrites
Synonym: Dendritic Spine
Synonym: Dendritic spine
Synonym: Dendritic spine apparatus
Synonym: Dendritic spine apparatus (body structure)
Synonym: Dendritic spine apparatus (cell structure)
Synonym: Spine, Dendritic
Synonym: Spines, Dendritic
Synonym: dendrite spine
Synonym: dendrites spines
Synonym: dendritic spine
Tree Number: T1.4.7.5.2
Tree Number: T2.23.4.2
Tree Number: T2.8.7.5.2
database_cross_reference: CHV:0000051585
database_cross_reference: CSP:2047-3635
database_cross_reference: FMA:67488
database_cross_reference: GO:GO:0043197
database_cross_reference: MSH:D049229
database_cross_reference: SNMI:T-E0591
database_cross_reference: SNOMEDCT_US:62670003
database_cross_reference: UWDA:67488

Flagella
type: Class
subclass of: Cell Surface Extensions
MCID: MC00005152
PMOID: PMO:00000451
Subclass_of: Cell Surface Extensions
Synonym: Flagellum
Synonym: flagella
Synonym: flagellum
Synonym: obsolete flagellum
Tree Number: T1.4.7.6
Tree Number: T2.8.7.6
database_cross_reference: AOD:0000016767
database_cross_reference: CHV:0000005075
database_cross_reference: CSP:0595-6140
database_cross_reference: FMA:67472
database_cross_reference: GO:GO:0005929
database_cross_reference: GO:GO:0019861
database_cross_reference: MSH:D005407
database_cross_reference: UWDA:67472

Sperm Tail
type: Class
subclass of: Flagella
subclass of: Spermatozoa
MCID: MC00012093
PMOID: PMO:00000452
Subclass_of: Flagella
Subclass_of: Spermatozoa
Synonym: Cauda (Spermatozoon)
Synonym: Cauda of sperm
Synonym: Cauda of spermatozoon
Synonym: Flagellum of spermatozoon
Synonym: Flagellum, Sperm
Synonym: Flagellums, Sperm
Synonym: Sperm Flagellum
Synonym: Sperm Flagellums
Synonym: Sperm Tails
Synonym: Spermatozoa.tail
Tree Number: T1.4.7.6.1
Tree Number: T2.15.3.2
Tree Number: T2.8.7.6.1
database_cross_reference: FMA:61843
database_cross_reference: GO:GO:0036126
database_cross_reference: LNC:LP34801-8
database_cross_reference: MSH:D013082
database_cross_reference: NCI:C33733
database_cross_reference: UWDA:61843

Microvilli
type: Class
subclass of: Cell Surface Extensions
MCID: MC00008299
PMOID: PMO:00000453
Subclass_of: Cell Surface Extensions
Synonym: Microvillus
Synonym: Microvillus (body structure)
Synonym: Microvillus (cell structure)
Synonym: microvilli
Synonym: microvillus
Tree Number: T1.4.7.7
Tree Number: T2.8.7.7
database_cross_reference: AOD:0000016768
database_cross_reference: CHV:0000008121
database_cross_reference: CSP:1831-7003
database_cross_reference: FMA:67296
database_cross_reference: GO:GO:0005902
database_cross_reference: MSH:D008871
database_cross_reference: NCI:C33112
database_cross_reference: SNMI:T-E0231
database_cross_reference: SNOMEDCT_US:49690003
database_cross_reference: UWDA:67296

Fimbriae, Bacterial
type: Class
subclass of: Cell Surface Extensions
MCID: MC00010216
PMOID: PMO:00000454
Subclass_of: Cell Surface Extensions
Synonym: BACT FIMBRIA
Synonym: BACT FIMBRIAE
Synonym: Bacterial Fimbria
Synonym: Bacterial Fimbriae
Synonym: Common Fimbria
Synonym: Common Fimbriae
Synonym: Common Pili
Synonym: Common Pilus
Synonym: Common pilum
Synonym: Common pilum (body structure)
Tree Number: T1.4.7.8
Tree Number: T2.8.7.8
database_cross_reference: CHV:0000022578
database_cross_reference: CSP:0597-6743
database_cross_reference: GO:GO:0009289
database_cross_reference: MSH:D010861
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:T-E0930
database_cross_reference: SNMI:T-E0931
database_cross_reference: SNOMEDCT_US:42529003
database_cross_reference: SNOMEDCT_US:54566003

Pseudopodia
type: Class
subclass of: Cell Surface Extensions
MCID: MC00010849
PMOID: PMO:00000455
Subclass_of: Cell Surface Extensions
Synonym: Pseudopodium
Synonym: pseudopod
Synonym: pseudopodium
Synonym: pseudopods
Tree Number: T1.4.7.9
Tree Number: T2.8.7.9
database_cross_reference: AOD:0000016769
database_cross_reference: CHV:0000010299
database_cross_reference: GO:GO:0031143
database_cross_reference: MSH:D011554

Neurites
type: Class
subclass of: Cell Surface Extensions
subclass of: Axons
subclass of: Neurons
MCID: MC00043154
PMOID: PMO:00000456
Subclass_of: Axons
Subclass_of: Cell Surface Extensions
Subclass_of: Neurons
Synonym: Appendage of neuron
Synonym: Extrasomatic region of neuron
Synonym: Neurite
Synonym: neurite
Synonym: neurites
Synonym: neuron process
Synonym: neuron projection
Synonym: neuron protrusion
Synonym: neuronal cell projection
Tree Number: T1.4.7.10
Tree Number: T2.23.13
Tree Number: T2.23.6.3.2
Tree Number: T2.8.7.10
database_cross_reference: AOD:0000027992
database_cross_reference: CHV:0000015429
database_cross_reference: CSP:2047-3613
database_cross_reference: CSP:2047-3635
database_cross_reference: FMA:61814
database_cross_reference: GO:GO:0043005
database_cross_reference: MSH:D016501
database_cross_reference: MTH:NOCODE
database_cross_reference: UWDA:61814

Pili, Sex
type: Class
subclass of: Cell Surface Extensions
MCID: MC00081637
PMOID: PMO:00000457
Subclass_of: Cell Surface Extensions
Synonym: Conjugative Pili
Synonym: Conjugative Pilus
Synonym: Pili, Conjugative
Synonym: Pilus, Conjugative
Synonym: Pilus, Sex
Synonym: Sex Pili
Synonym: Sex Pilus
Synonym: Sex pilum
Synonym: Sex pilum (body structure)
Synonym: Sex pilum (cell structure)
Tree Number: T1.4.7.11
Tree Number: T2.8.7.11
database_cross_reference: MSH:D018933
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:T-E0932
database_cross_reference: SNOMEDCT_US:69540001

Cellulosomes
type: Class
subclass of: Cell Surface Extensions
MCID: MC00421626
PMOID: PMO:00000458
Subclass_of: Cell Surface Extensions
Synonym: Cellulosome
Synonym: cellulosome
Tree Number: T1.4.7.12
Tree Number: T2.8.7.12
database_cross_reference: GO:GO:0043263
database_cross_reference: MSH:D044603

Stereocilia
type: Class
subclass of: Cell Surface Extensions
MCID: MC00077443
PMOID: PMO:00000459
Subclass_of: Cell Surface Extensions
Synonym: Stereocilium
Synonym: Stereocilium (body structure)
Synonym: Stereocilium (cell structure)
Synonym: Stereovilli
Synonym: Stereovillus
Synonym: stereocilium
Tree Number: T1.4.7.13
Tree Number: T2.8.7.13
database_cross_reference: FMA:67317
database_cross_reference: GO:GO:0032420
database_cross_reference: MSH:D059547
database_cross_reference: NCI:C33614
database_cross_reference: SNMI:T-E0233
database_cross_reference: SNOMEDCT_US:36828001
database_cross_reference: UWDA:67317

Cell Nucleus
type: Class
subclass of: Intracellular Space
MCID: MC00002449
PMOID: PMO:00000460
Subclass_of: Intracellular Space
Synonym: Cell Nuclei
Synonym: Cell nuclei
Synonym: Cell nucleus
Synonym: NUCLEUS
Synonym: Nuclei, Cell
Synonym: Nucleic
Synonym: Nucleus
Synonym: Nucleus (body structure)
Synonym: Nucleus (cell structure)
Synonym: Nucleus of cell
Tree Number: T1.4.8.1
Tree Number: T2.8.8.1
database_cross_reference: AOD:0000016722
database_cross_reference: CHV:0000002596
database_cross_reference: CSP:0593-3664
database_cross_reference: FMA:63840
database_cross_reference: GO:GO:0005634
database_cross_reference: LCH_NW:sh85021658
database_cross_reference: LNC:LP182349-3
database_cross_reference: MSH:D002467
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13197
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13197
database_cross_reference: NCI_NCI-GLOSS:CDR0000597161
database_cross_reference: PSY:08070
database_cross_reference: SNM:T-YX030
database_cross_reference: SNMI:T-E0100
database_cross_reference: SNOMEDCT_US:84640000
database_cross_reference: UWDA:63840

Cell Nucleus Structures
type: Class
subclass of: Cell Nucleus
MCID: MC00309999
PMOID: PMO:00000461
Subclass_of: Cell Nucleus
Synonym: Cell Nucleus Structure
Synonym: Cell nuclear region
Synonym: Part of cell nucleus
Synonym: Region of cell nucleus
Synonym: Structure, Cell Nucleus
Synonym: Structures, Cell Nucleus
Tree Number: T1.4.8.1.1
Tree Number: T2.8.8.1.1
database_cross_reference: FMA:66846
database_cross_reference: MSH:D022003
database_cross_reference: UWDA:66846

Chromatin
type: Class
subclass of: PMO:00023650
MCID: MC00002806
PMOID: PMO:00000469
Subclass_of: Nucleoproteins
Synonym: Chromatin (substance)
Synonym: Chromatin [Chemical/Ingredient]
Synonym: Chromatin, NOS
Synonym: Chromatins
Synonym: Karyoplasm
Synonym: Nuclear sap
Synonym: chromatin
Synonym: chromoplasm
Tree Number: T6.10.3.37.1
database_cross_reference: AOD:0000002903
database_cross_reference: AOD:0000022111
database_cross_reference: CHV:0000002926
database_cross_reference: CSP:1255-9141
database_cross_reference: FMA:67526
database_cross_reference: LCH:U001007
database_cross_reference: LCH_NW:sh85025333
database_cross_reference: LNC:LP30645-3
database_cross_reference: MSH:D002843
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13201
database_cross_reference: NDFRT:N0000169072
database_cross_reference: SNM:T-YX060
database_cross_reference: SNM:T-YX070
database_cross_reference: SNMI:T-E0120
database_cross_reference: SNOMEDCT_US:60085001
database_cross_reference: UWDA:67526

Micronuclei, Chromosome-Defective
type: Class
subclass of: Cell Nucleus
MCID: MC00516458
PMOID: PMO:00000481
Subclass_of: Cell Nucleus
Synonym: Chromosome Defective Micronuclei
Synonym: Chromosome-Defective Micronuclei
Synonym: Chromosome-Defective Micronucleus
Synonym: Micronuclei, Chromosome Defective
Synonym: Micronuclei, Chromosome-Defective [Disease/Finding]
Synonym: Micronucleus, Chromosome Defective
Synonym: Micronucleus, Chromosome-Defective
Tree Number: T1.4.8.1.2
Tree Number: T2.8.8.1.2
database_cross_reference: MSH:D048629
database_cross_reference: NDFRT:N0000011014

Micronucleus, Germline
type: Class
subclass of: Cell Nucleus
MCID: MC00516460
PMOID: PMO:00000482
Subclass_of: Cell Nucleus
Synonym: Germinal Micronucleus
Synonym: Germline Micronuclei
Synonym: Germline Micronucleus
Synonym: Micronuclei, Germline
Synonym: Micronucleus, Germinal
Tree Number: T1.4.8.1.3
Tree Number: T2.8.8.1.3
database_cross_reference: MSH:D048631

Macronucleus
type: Class
subclass of: Cell Nucleus
MCID: MC00520346
PMOID: PMO:00000483
Subclass_of: Cell Nucleus
Synonym: Macronuclei
Synonym: macronucleus
Tree Number: T1.4.8.1.4
Tree Number: T2.8.8.1.4
database_cross_reference: GO:GO:0031039
database_cross_reference: MSH:D048648
database_cross_reference: MTH:NOCODE

Cytoplasm
type: Class
subclass of: Intracellular Space
MCID: MC00003515
PMOID: PMO:00000484
Subclass_of: Intracellular Space
Synonym: Cytoplasma
Synonym: Cytoplasmic
Synonym: Cytoplasms
Synonym: cytoplasm
Synonym: cytoplasma
Tree Number: T1.4.8.2
Tree Number: T2.8.8.2
database_cross_reference: AOD:0000016753
database_cross_reference: CHV:0000003589
database_cross_reference: CSP:0595-2394
database_cross_reference: FMA:66835
database_cross_reference: GO:GO:0005737
database_cross_reference: LCH:U001262
database_cross_reference: LCH_NW:sh85035251
database_cross_reference: MSH:D003593
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13226
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044586
database_cross_reference: PSY:12940
database_cross_reference: SNM:T-YX020
database_cross_reference: SNMI:T-E0300
database_cross_reference: SNOMEDCT_US:62035001
database_cross_reference: UWDA:66835

Cytoplasmic Structures
type: Class
subclass of: Cytoplasm
MCID: MC00310004
PMOID: PMO:00000485
Subclass_of: Cytoplasm
Synonym: Cytoplasmic Structure
Synonym: Structure, Cytoplasmic
Synonym: Structures, Cytoplasmic
Tree Number: T1.4.8.2.2
Tree Number: T2.8.8.2.2
database_cross_reference: MSH:D022083

Nissl Bodies
type: Class
subclass of: Neurons
MCID: MC00008916
PMOID: PMO:00000491
Subclass_of: Neurons
Synonym: Bodies, Nissl
Synonym: GER aggregate
Synonym: GER aggregate (body structure)
Synonym: GER aggregate (body structure) [Ambiguous]
Synonym: GER aggregate, NOS
Synonym: Granule, Nissl
Synonym: Granules, Nissl
Synonym: Nissl Body
Synonym: Nissl Granule
Synonym: Nissl Granules
Tree Number: T2.23.11
database_cross_reference: CHV:0000008728
database_cross_reference: CSP:4000-0266
database_cross_reference: FMA:67367
database_cross_reference: LCH:U003238
database_cross_reference: LCH_NW:sh85092038
database_cross_reference: MSH:D009562
database_cross_reference: NCI:C33170
database_cross_reference: SNMI:T-E0564
database_cross_reference: SNOMEDCT_US:209599006
database_cross_reference: SNOMEDCT_US:54088008
database_cross_reference: UWDA:67367

Melanosomes
type: Class
subclass of: Melanophores
subclass of: Melanocytes
MCID: MC00008000
PMOID: PMO:00000493
Subclass_of: Melanocytes
Subclass_of: Melanophores
Synonym: Melanosome
Synonym: melanosome
Synonym: melanosomes
Tree Number: T2.12.11.1
Tree Number: T2.12.4.1.1
database_cross_reference: CHV:0000007897
database_cross_reference: CSP:2328-1321
database_cross_reference: FMA:70957
database_cross_reference: GO:GO:0042470
database_cross_reference: MSH:D020460
database_cross_reference: UWDA:70957

Filamins
type: Class
subclass of: PMO:00022553
MCID: MC00026831
PMOID: PMO:00000498
Subclass_of: Contractile Proteins
Synonym: Filamin
Synonym: Filamins [Chemical/Ingredient]
Synonym: filamin
Tree Number: T6.10.3.15.2
database_cross_reference: CSP:4000-0105
database_cross_reference: FMA:61779
database_cross_reference: MSH:D064448
database_cross_reference: NDFRT:N0000189401
database_cross_reference: UWDA:61779

Neuropil Threads
type: Class
subclass of: Neuropil
MCID: MC00163103
PMOID: PMO:00000500
Subclass_of: Neuropil
Synonym: Neuropil Thread
Synonym: Neuropil thread
Synonym: Neuropil thread (morphologic abnormality)
Tree Number: T2.22.6.1
Tree Number: T2.23.16.1
database_cross_reference: MSH:D019600
database_cross_reference: SNMI:M-62332
database_cross_reference: SNOMEDCT_US:33475000

Neurofibrils
type: Class
subclass of: Neurons
MCID: MC00008819
PMOID: PMO:00000507
Subclass_of: Neurons
Synonym: Neurofibril
Synonym: neurofibril
Tree Number: T2.23.8
database_cross_reference: CSP:2047-3691
database_cross_reference: LCH:U003186
database_cross_reference: LCH_NW:sh85091119
database_cross_reference: MSH:D009454

Neurofibrillary Tangles
type: Class
subclass of: Neurofibrils
MCID: MC00043285
PMOID: PMO:00000508
Subclass_of: Neurofibrils
Synonym: Alzheimer's neurofibrillary change
Synonym: Alzheimer's neurofibrillary degeneration
Synonym: Argentophilic neuronal inclusion
Synonym: NFT
Synonym: Neurofibrillary Tangle
Synonym: Neurofibrillary degeneration
Synonym: Neurofibrillary degeneration (morphologic abnormality)
Synonym: Neurofibrillary tangle
Synonym: Neurofibrillary tangles
Synonym: Neurofibrillary tangles composed of disordered microtubules in neurons
Tree Number: T2.23.8.1
database_cross_reference: CHV:0000015583
database_cross_reference: CSP:2042-3269
database_cross_reference: HPO:HP:0002185
database_cross_reference: MDR:10077196
database_cross_reference: MSH:D016874
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU000778
database_cross_reference: SNM:M-50630
database_cross_reference: SNMI:M-50630
database_cross_reference: SNOMEDCT_US:85775002

Acrosome
type: Class
subclass of: Sperm Head
MCID: MC00000279
PMOID: PMO:00000537
Subclass_of: Sperm Head
Synonym: Acrosomal cap
Synonym: Acrosomal granule
Synonym: Acrosomal granule (body structure)
Synonym: Acrosomal granule (cell structure)
Synonym: Acrosomal vesicle
Synonym: Acrosomal vesicle (body structure)
Synonym: Acrosomal vesicle (cell structure)
Synonym: Acrosomes
Synonym: Lysosome of male germ cell
Synonym: Lysosome of male germ cell (body structure)
Tree Number: T2.15.3.1.1
database_cross_reference: CHV:0000000660
database_cross_reference: CSP:1138-6471
database_cross_reference: FMA:84869
database_cross_reference: GO:GO:0001669
database_cross_reference: MSH:D000177
database_cross_reference: SNMI:T-E0650
database_cross_reference: SNMI:T-E0651
database_cross_reference: SNMI:T-E0653
database_cross_reference: SNOMEDCT_US:30516005
database_cross_reference: SNOMEDCT_US:52568003
database_cross_reference: SNOMEDCT_US:75801009

Trichomes
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
MCID: MC00943896
PMOID: PMO:00000551
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Indumentum
Synonym: Indumentums
Synonym: Trichome
Tree Number: T1.4.9
Tree Number: T2.8.9
database_cross_reference: MSH:D064201

Cell Body
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
MCID: MC00762016
PMOID: PMO:00000552
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Bodies, Cell
Synonym: Body, Cell
Synonym: Cell Bodies
Synonym: Cell body
Synonym: Cell soma
Synonym: cell body
Synonym: cell soma
Tree Number: T1.4.10
Tree Number: T2.8.10
database_cross_reference: FMA:67301
database_cross_reference: GO:GO:0044297
database_cross_reference: MSH:D066146
database_cross_reference: MTH:NOCODE
database_cross_reference: UWDA:67301

Molecular Sequence
type: Class
subclass of: Anatomical Structure
PMOID: PMO:00000553
Subclass_of: Anatomical Structure
Tree Number: T1.5

Nucleotide Sequence
type: Class
subclass of: Molecular Sequence
MCID: MC00001512
PMOID: PMO:00000554
Subclass_of: Molecular Sequence
Synonym: BASE SEQ
Synonym: Base Sequence
Synonym: Base Sequences
Synonym: Base sequence
Synonym: Base sequence (finding)
Synonym: NUCLEOTIDE SEQ
Synonym: Nucleotide Sequences
Synonym: Nucleotide sequence
Synonym: Seq
Synonym: Sequence
Tree Number: T1.5.1
database_cross_reference: AOD:0000022133
database_cross_reference: CHV:0000001719
database_cross_reference: CSP:2102-8337
database_cross_reference: LCH_NW:sh85093159
database_cross_reference: LNC:LP62164-6
database_cross_reference: MSH:D001483
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45374
database_cross_reference: NCI:TCGA
database_cross_reference: SNMI:F-E2100
database_cross_reference: SNOMEDCT_US:72633008

Amino Acid Sequence
type: Class
subclass of: Molecular Sequence
MCID: MC00000737
PMOID: PMO:00000555
Subclass_of: Molecular Sequence
Synonym: AA SEQ
Synonym: AMINO ACID SEQ
Synonym: AMINO ACID SEQUENCE
Synonym: Amino Acid Sequences
Synonym: Amino acid sequence
Synonym: Amino acid sequence (finding)
Synonym: Primary Protein Structure
Synonym: Primary Protein Structures
Synonym: Protein Sequence
Synonym: Protein Structure, Primary
Tree Number: T1.5.2
database_cross_reference: CHV:0000001007
database_cross_reference: CSP:2446-2100
database_cross_reference: LCH:U000193
database_cross_reference: LCH_NW:sh85004484
database_cross_reference: MSH:D000595
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13187
database_cross_reference: NCI_FDA:C13187
database_cross_reference: NCI_NCI-GLOSS:CDR0000044184
database_cross_reference: SNMI:F-E2010
database_cross_reference: SNOMEDCT_US:28820008

Carbohydrate Sequence
type: Class
subclass of: Molecular Sequence
MCID: MC00002231
PMOID: PMO:00000556
Subclass_of: Molecular Sequence
Synonym: CARB SEQ
Synonym: Carbohydrate Sequences
Synonym: Carbohydrate sequence
Synonym: Carbohydrate sequence (finding)
Synonym: Sequence, Carbohydrate
Synonym: Sequences, Carbohydrate
Synonym: carbohydrate sequence
Tree Number: T1.5.3
database_cross_reference: CSP:0551-8882
database_cross_reference: MSH:D002240
database_cross_reference: SNMI:F-E2060
database_cross_reference: SNOMEDCT_US:26608005

Cell
type: Class
subclass of: Thing
MCID: MC00002459
PMOID: PMO:00000557
Subclass_of: owl:Thing
Synonym: Cell Type
Synonym: Cell Types
Synonym: Cell structure
Synonym: Cell structure (body structure)
Synonym: Cell structure (cell structure)
Synonym: Cell, NOS
Synonym: Cells
Synonym: Cells (Biology)
Synonym: Cells set
Synonym: Cellula
Tree Number: T2
database_cross_reference: CHV:0000002603
database_cross_reference: CSP:0605-5409
database_cross_reference: FMA:68646
database_cross_reference: FMA:71954
database_cross_reference: GO:GO:0005623
database_cross_reference: LCH:U000874
database_cross_reference: LCH_NW:sh85021678
database_cross_reference: LNC:LP14738-6
database_cross_reference: LNC:LP174115-8
database_cross_reference: LNC:MTHU001933
database_cross_reference: MSH:D002477
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12508
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046476
database_cross_reference: NCI_UCUM:C12508
database_cross_reference: PSY:08080
database_cross_reference: SNM:T-YX000
database_cross_reference: SNM:U000525
database_cross_reference: SNMI:T-E0000
database_cross_reference: SNOMEDCT_US:4421005
database_cross_reference: UWDA:68646
database_cross_reference: UWDA:71954

Acinar Cells
type: Class
subclass of: Cell
MCID: MC00182428
PMOID: PMO:00000558
Subclass_of: Cell
Synonym: Acinar Cell
Synonym: Acinar cell
Synonym: Acini Cell
Synonym: Acini Cells
Synonym: Acinic Cell
Synonym: Acinic Cells
Synonym: Acinous Cell
Synonym: Acinous Cells
Synonym: Acinus Cell
Synonym: Acinus Cells
Tree Number: T2.1
database_cross_reference: AOD:0000016825
database_cross_reference: CHV:0000041472
database_cross_reference: CSP:4000-0104
database_cross_reference: FMA:83625
database_cross_reference: MSH:D061354
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13077
database_cross_reference: NCI:TCGA

Antibody-Producing Cells
type: Class
subclass of: Cell
MCID: MC00001027
PMOID: PMO:00000559
Subclass_of: Cell
Synonym: Antibody Producing Cell
Synonym: Antibody Producing Cells
Synonym: Antibody-Producing Cell
Synonym: Cell, Antibody-Producing
Synonym: Cell, Immunoglobulin-Producing
Synonym: Cells, Antibody-Producing
Synonym: Cells, Immunoglobulin-Producing
Synonym: IG PRODUCING CELLS
Synonym: Immunoglobulin Producing Cells
Synonym: Immunoglobulin-Producing Cell
Tree Number: T2.2
database_cross_reference: MSH:D000921
database_cross_reference: NCI:C12611

B-Lymphocytes
type: Class
subclass of: Antibody-Producing Cells
MCID: MC00001457
PMOID: PMO:00000560
Subclass_of: Antibody-Producing Cells
Synonym: B Cell
Synonym: B Cells
Synonym: B Lymphocytes
Synonym: B cell
Synonym: B cells
Synonym: B lymphocyte
Synonym: B lymphocyte (cell)
Synonym: B-Cell
Synonym: B-Cells
Synonym: B-Lymphocyte
Tree Number: T2.2.1
database_cross_reference: AOD:0000017487
database_cross_reference: AOD:0000027929
database_cross_reference: AOD:0000027931
database_cross_reference: CHV:0000001646
database_cross_reference: CSP:0435-7975
database_cross_reference: FMA:62869
database_cross_reference: LCH_NW:sh85010707
database_cross_reference: LNC:LA4275-9
database_cross_reference: LNC:LP15088-5
database_cross_reference: LNC:LP36861-0
database_cross_reference: LNC:MTHU002435
database_cross_reference: MEDCIN:12035
database_cross_reference: MSH:D001402
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12474
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044953
database_cross_reference: NCI_NCI-GLOSS:CDR0000045611
database_cross_reference: RCD:X80V8
database_cross_reference: SNM:F-40640
database_cross_reference: SNMI:F-C6040
database_cross_reference: SNOMEDCT_US:112130006

Plasma Cells
type: Class
subclass of: B-Lymphocytes
MCID: MC00010289
PMOID: PMO:00000561
Subclass_of: B-Lymphocytes
Synonym: Blood plasma cell
Synonym: Cell, Plasma
Synonym: Cells, Plasma
Synonym: Plasma Cell
Synonym: Plasma cell
Synonym: Plasma cell (body structure)
Synonym: Plasma cell (cell)
Synonym: Plasma cell, NOS
Synonym: Plasma cells
Synonym: Plasma cells.centroblasts
Tree Number: T2.2.1.1
database_cross_reference: AOD:0000017489
database_cross_reference: AOD:0000027935
database_cross_reference: CHV:0000009807
database_cross_reference: CSP:0432-7249
database_cross_reference: FMA:70574
database_cross_reference: FMA:84370
database_cross_reference: LCH:U003706
database_cross_reference: LCH_NW:sh85103058
database_cross_reference: LNC:LP14037-3
database_cross_reference: LNC:LP183494-6
database_cross_reference: LNC:LP183495-3
database_cross_reference: LNC:LP68360-4
database_cross_reference: LNC:MTHU011655
database_cross_reference: MSH:D010950
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12486
database_cross_reference: NCI_NCI-GLOSS:CDR0000044795
database_cross_reference: NCI_NCI-GLOSS:CDR0000046230
database_cross_reference: NCI_NCI-GLOSS:CDR0000633941
database_cross_reference: RCD:X80V9
database_cross_reference: SNM:T-05320
database_cross_reference: SNM:T-0X270
database_cross_reference: SNMI:T-C1750
database_cross_reference: SNOMEDCT_US:113335003

B-Lymphocyte Subsets
type: Class
subclass of: B-Lymphocytes
PMOID: PMO:00000562
Subclass_of: B-Lymphocytes
Tree Number: T2.2.1.2

B-Lymphocytes, Regulatory
type: Class
subclass of: B-Lymphocyte Subsets
MCID: MC00831055
PMOID: PMO:00000563
Subclass_of: B-Lymphocyte Subsets
Synonym: B Cells, Regulatory
Synonym: B Lymphocytes, Regulatory
Synonym: B-Cell, Regulatory
Synonym: B-Cells, Regulatory
Synonym: B-Lymphocyte, Regulatory
Synonym: Breg
Synonym: Breg Cell
Synonym: Breg Cells
Synonym: Bregs
Synonym: Cell, Breg
Tree Number: T2.2.1.2.1
database_cross_reference: MSH:D060151
database_cross_reference: NCI:C113502

Antigen-Presenting Cells
type: Class
subclass of: Cell
MCID: MC00001048
PMOID: PMO:00000564
Subclass_of: Cell
Synonym: ACCESSORY CELL IMMUNOL
Synonym: ACCESSORY CELLS IMMUNOL
Synonym: APC
Synonym: Accessory Cell
Synonym: Accessory Cell, Immunologic
Synonym: Accessory Cells, Immunologic
Synonym: Antigen Presenting Cell
Synonym: Antigen Presenting Cells
Synonym: Antigen Processing Cell
Synonym: Antigen presenting cell
Tree Number: T2.3
database_cross_reference: CHV:0000001291
database_cross_reference: CSP:0605-5488
database_cross_reference: FMA:273565
database_cross_reference: LCH_NW:sh87006338
database_cross_reference: MSH:D000938
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12621
database_cross_reference: NCI_NCI-GLOSS:CDR0000043977
database_cross_reference: NCI_NCI-GLOSS:CDR0000044914

Dendritic Cells
type: Class
subclass of: Antigen-Presenting Cells
subclass of: Epithelial Cells
MCID: MC00003620
PMOID: PMO:00000565
Subclass_of: Antigen-Presenting Cells
Subclass_of: Epithelial Cells
Synonym: Cell, Dendritic
Synonym: Cells, Dendritic
Synonym: Dendritic Cell
Synonym: Dendritic cell
Synonym: Dendritic cells
Synonym: cell dendritic
Synonym: cell dendritics
Synonym: cells dendritic
Synonym: dendritic cell
Synonym: dendritic cells
Tree Number: T2.12.5
Tree Number: T2.3.1
database_cross_reference: CHV:0000003695
database_cross_reference: CSP:0432-1437
database_cross_reference: LCH_NW:sh91001535
database_cross_reference: MSH:D003713
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12583
database_cross_reference: NCI_NCI-GLOSS:CDR0000044948
database_cross_reference: SNM:T-01151
database_cross_reference: SNMI:T-01151
database_cross_reference: SNOMEDCT_US:9683001

Langerhans Cells
type: Class
subclass of: Dendritic Cells
MCID: MC00007357
PMOID: PMO:00000566
Subclass_of: Dendritic Cells
Synonym: Cell, Epidermal Dendritic
Synonym: Cells, Epidermal Dendritic
Synonym: Cells, Langerhans
Synonym: Dendritic Cell, Epidermal
Synonym: Dendritic Cells, Epidermal
Synonym: Epidermal Dendritic Cell
Synonym: Epidermal Dendritic Cells
Synonym: Langerhans Cell
Synonym: Langerhans cell
Synonym: Langerhans cells
Tree Number: T2.12.5.1
Tree Number: T2.3.1.1
database_cross_reference: CHV:0000007201
database_cross_reference: CSP:2716-1309
database_cross_reference: FMA:63072
database_cross_reference: LCH_NW:sh90001839
database_cross_reference: MSH:D007801
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12584
database_cross_reference: SNM:T-01153
database_cross_reference: SNMI:T-01153
database_cross_reference: SNOMEDCT_US:76322003
database_cross_reference: UWDA:63072

Blood Cells
type: Class
subclass of: Cell
MCID: MC00001822
PMOID: PMO:00000567
Subclass_of: Cell
Synonym: Blood Cell
Synonym: Blood Corpuscle
Synonym: Blood Corpuscles
Synonym: Blood cell
Synonym: Blood cell (body structure)
Synonym: Blood cell (cell)
Synonym: Blood cell, NOS
Synonym: Blood cells
Synonym: Cell, Blood
Synonym: Cells, Blood
Tree Number: T2.4
database_cross_reference: AOD:0000017446
database_cross_reference: AOD:0000027887
database_cross_reference: CHV:0000001985
database_cross_reference: CSP:0435-0475
database_cross_reference: FMA:62844
database_cross_reference: FMA:86697
database_cross_reference: LCH:U000613
database_cross_reference: LCH_NW:sh85014968
database_cross_reference: MEDLINEPLUS:6037
database_cross_reference: MEDLINEPLUS:6351
database_cross_reference: MSH:D001773
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12519
database_cross_reference: PSY:06220
database_cross_reference: SNM:T-0X100
database_cross_reference: SNMI:T-C2100
database_cross_reference: SNOMEDCT_US:63370004
database_cross_reference: UWDA:62844

Blood Platelets
type: Class
subclass of: Blood Cells
MCID: MC00001833
PMOID: PMO:00000568
Subclass_of: Blood Cells
Synonym: Bizzozero Corpuscle
Synonym: Bizzozero's corpuscle/cell
Synonym: Blood Platelet
Synonym: Blood platelet
Synonym: Blood platelets
Synonym: Deetjeen's body
Synonym: Deetjen Body
Synonym: Hayem's elementary corpuscle
Synonym: Marrow platelet
Synonym: PLATELET
Tree Number: T2.4.1
database_cross_reference: AOD:0000002647
database_cross_reference: AOD:0000023555
database_cross_reference: AOD:0000027914
database_cross_reference: AOD:0000027916
database_cross_reference: AOD:0000027918
database_cross_reference: AOD:0000027920
database_cross_reference: ATC:B05AX02
database_cross_reference: CCPSS:1013247
database_cross_reference: CCPSS:1013251
database_cross_reference: CHV:0000002006
database_cross_reference: CSP:0445-2127
database_cross_reference: FMA:62851
database_cross_reference: LCH:U000619
database_cross_reference: LCH_NW:sh85015006
database_cross_reference: LNC:LP14597-6
database_cross_reference: LNC:LP16772-3
database_cross_reference: LNC:LP70360-0
database_cross_reference: LNC:LP7631-7
database_cross_reference: LNC:MTHU002432
database_cross_reference: LNC:MTHU008063
database_cross_reference: MSH:D001792
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000206
database_cross_reference: NCI:C12520
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12520
database_cross_reference: NCI_NCI-GLOSS:CDR0000045840
database_cross_reference: NCI_NCI-GLOSS:CDR0000046614
database_cross_reference: PSY:06320
database_cross_reference: PSY:39100
database_cross_reference: RCD:X80Ve
database_cross_reference: SNM:T-06560
database_cross_reference: SNM:T-0X330
database_cross_reference: SNMI:T-C1560
database_cross_reference: SNOMEDCT_US:16378004
database_cross_reference: SNOMEDCT_US:256396005
database_cross_reference: SNOMEDCT_US:259727009
database_cross_reference: UWDA:62851

Erythrocytes
type: Class
subclass of: Blood Cells
subclass of: Erythroid Cells
MCID: MC00004683
PMOID: PMO:00000569
Subclass_of: Blood Cells
Subclass_of: Erythroid Cells
Synonym: Anucleate erythrocyte
Synonym: Blood Cell, Red
Synonym: Blood Cells, Red
Synonym: Blood Corpuscle, Red
Synonym: Blood Corpuscles
Synonym: Blood Corpuscles, Red
Synonym: Blood Erythrocyte
Synonym: Blood erythrocyte
Synonym: Blood erythrocytic cell
Synonym: Blood normocyte
Tree Number: T2.13.1
Tree Number: T2.4.2
database_cross_reference: AOD:0000007247
database_cross_reference: AOD:0000024260
database_cross_reference: AOD:0000027886
database_cross_reference: ATC:B05AX01
database_cross_reference: CCPSS:1011053
database_cross_reference: CHV:0000004629
database_cross_reference: CSP:0435-1425
database_cross_reference: FMA:62845
database_cross_reference: LCH:U001649
database_cross_reference: LCH_NW:sh85044747
database_cross_reference: LNC:LA12896-9
database_cross_reference: LNC:LP14304-7
database_cross_reference: LNC:LP16699-8
database_cross_reference: LNC:LP7536-8
database_cross_reference: LNC:MTHU001098
database_cross_reference: LNC:MTHU051574
database_cross_reference: MSH:D004912
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12521
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12521
database_cross_reference: NCI_NCI-GLOSS:CDR0000044401
database_cross_reference: NCI_NCI-GLOSS:CDR0000046124
database_cross_reference: NCI_NCI-GLOSS:CDR0000046425
database_cross_reference: PSY:17860
database_cross_reference: PSY:43467
database_cross_reference: RCD:X80Td
database_cross_reference: SNM:T-06160
database_cross_reference: SNM:T-0X110
database_cross_reference: SNM:T-0X120
database_cross_reference: SNMI:T-C1160
database_cross_reference: SNOMEDCT_US:256376002
database_cross_reference: SNOMEDCT_US:41898006
database_cross_reference: UWDA:62845

Erythrocytes, Abnormal
type: Class
subclass of: Erythrocytes
MCID: MC00004684
PMOID: PMO:00000570
Subclass_of: Erythrocytes
Synonym: 631-634 ABNORMAL RED BLOOD CELLS
Synonym: ABNORM ERYTHROCYTES
Synonym: ABNORMAL RED BLOOD CELLS
Synonym: Abnormal Erythrocyte
Synonym: Abnormal Erythrocytes
Synonym: Abnormal Red Blood Cell
Synonym: Abnormal erythrocyte
Synonym: Abnormal erythrocyte morphology
Synonym: Abnormal erythrocyte, NOS
Synonym: Abnormal red blood cell
Tree Number: T2.13.1.1
Tree Number: T2.4.2.2
database_cross_reference: CHV:0000004630
database_cross_reference: HPO:HP:0001877
database_cross_reference: MSH:D004913
database_cross_reference: MTH:U003408
database_cross_reference: NCI:C12522
database_cross_reference: SNMI:M-63100
database_cross_reference: SNOMEDCT_US:12222001
database_cross_reference: SNOMEDCT_US:397019006

Acanthocytes
type: Class
subclass of: Erythrocytes, Abnormal
MCID: MC00000154
PMOID: PMO:00000571
Subclass_of: Erythrocytes, Abnormal
Synonym: Acanthocyte
Synonym: Acanthocyte (cell)
Synonym: Acanthocyte (morphologic abnormality)
Synonym: Acanthocyte [dup] (morphologic abnormality)
Synonym: Acanthrocyte
Synonym: Crenated Red Blood Cell
Synonym: Crenated cell
Synonym: SPUR CELL
Synonym: Spiny prickle cell
Synonym: Spur Cell
Tree Number: T2.13.1.1.1
Tree Number: T2.4.2.2.1
database_cross_reference: CHV:0000000570
database_cross_reference: DXP:U003790
database_cross_reference: LNC:LA11190-8
database_cross_reference: LNC:LP17674-0
database_cross_reference: LNC:MTHU024320
database_cross_reference: MSH:D000050
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12523
database_cross_reference: OMIM:MTHU003553
database_cross_reference: RCD:X76u0
database_cross_reference: RCD:X80Tw
database_cross_reference: SNM:M-78210
database_cross_reference: SNM:M-78260
database_cross_reference: SNMI:M-63170
database_cross_reference: SNOMEDCT_US:250250008
database_cross_reference: SNOMEDCT_US:259685005
database_cross_reference: SNOMEDCT_US:63599005

Megaloblasts
type: Class
subclass of: Erythrocytes, Abnormal
MCID: MC00007983
PMOID: PMO:00000572
Subclass_of: Erythrocytes, Abnormal
Synonym: Megaloblast
Synonym: megaloblast
Synonym: megaloblasts
Tree Number: T2.13.1.1.2
Tree Number: T2.4.2.2.3
database_cross_reference: AOD:0000017451
database_cross_reference: CHV:0000007884
database_cross_reference: LNC:LP68315-8
database_cross_reference: LNC:MTHU032486
database_cross_reference: MSH:D008534
database_cross_reference: NCI:C12524

Spherocytes
type: Class
subclass of: Erythrocytes, Abnormal
MCID: MC00012114
PMOID: PMO:00000573
Subclass_of: Erythrocytes, Abnormal
Synonym: SPHEROCYTES
Synonym: Spherocyte
Synonym: Spherocyte (cell)
Synonym: Spherocyte (morphologic abnormality)
Synonym: Spherocytosis
Synonym: spherocyte
Synonym: spherocytes
Tree Number: T2.13.1.1.3
Tree Number: T2.4.2.2.4
database_cross_reference: CHV:0000011597
database_cross_reference: DXP:U003771
database_cross_reference: HPO:HP:0004444
database_cross_reference: LNC:LA11212-0
database_cross_reference: LNC:LP17717-7
database_cross_reference: LNC:MTHU024361
database_cross_reference: MSH:D013102
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12525
database_cross_reference: OMIM:MTHU048730
database_cross_reference: RCD:X80Tq
database_cross_reference: SNM:M-78330
database_cross_reference: SNMI:M-63280
database_cross_reference: SNOMEDCT_US:17235000
database_cross_reference: SNOMEDCT_US:259682008

Reticulocytes
type: Class
subclass of: Erythrocytes
subclass of: Bone Marrow Cells
MCID: MC00011297
PMOID: PMO:00000574
Subclass_of: Bone Marrow Cells
Subclass_of: Erythrocytes
Synonym: Blood reticulocyte
Synonym: Diffusely basophilic erythrocyte
Synonym: Marrow reticulocyte
Synonym: Polychromatophilic erythrocyte
Synonym: Reticulocyte
Synonym: Reticulocyte (cell)
Synonym: cells reticulocytes
Synonym: reticulocyte
Synonym: reticulocytes
Tree Number: T2.13.1.2
Tree Number: T2.4.2.3
Tree Number: T2.5.5
database_cross_reference: AOD:0000017459
database_cross_reference: CHV:0000010787
database_cross_reference: CSP:0435-3225
database_cross_reference: FMA:66785
database_cross_reference: LCH:U004103
database_cross_reference: LCH_NW:sh85113319
database_cross_reference: LNC:LP16487-8
database_cross_reference: LNC:MTHU004708
database_cross_reference: MSH:D012156
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12528
database_cross_reference: RCD:X80Te
database_cross_reference: SNM:T-06150
database_cross_reference: SNM:T-0X130
database_cross_reference: SNMI:T-C1150
database_cross_reference: SNOMEDCT_US:52802009
database_cross_reference: UWDA:66785

Hemocytes
type: Class
subclass of: Blood Cells
MCID: MC00006056
PMOID: PMO:00000575
Subclass_of: Blood Cells
Synonym: Hematocyte
Synonym: Hemocyte
Synonym: Hemocytes (cell)
Synonym: hemocyte
Synonym: hemocytes
Tree Number: T2.4.3
database_cross_reference: CHV:0000005976
database_cross_reference: FMA:83618
database_cross_reference: MSH:D006434
database_cross_reference: MTH:NOCODE

Leukocytes
type: Class
subclass of: Blood Cells
MCID: MC00007509
PMOID: PMO:00000576
Subclass_of: Blood Cells
Synonym: Blood Cell, White
Synonym: Blood Cells, White
Synonym: Blood Corpuscle, White
Synonym: Blood Corpuscles, White
Synonym: Blood leukocyte
Synonym: Corpuscle, White Blood
Synonym: Corpuscles, White Blood
Synonym: Leucocyte
Synonym: Leucocytes
Synonym: Leukocyte
Tree Number: T2.4.4
database_cross_reference: AOD:0000005918
database_cross_reference: AOD:0000027890
database_cross_reference: AOD:0000027891
database_cross_reference: CCPSS:1014703
database_cross_reference: CHV:0000007360
database_cross_reference: CSP:0435-4175
database_cross_reference: FMA:62852
database_cross_reference: LCH_NW:sh85076269
database_cross_reference: LNC:LA12894-4
database_cross_reference: LNC:LP14419-3
database_cross_reference: LNC:LP157588-7
database_cross_reference: LNC:LP20670-3
database_cross_reference: LNC:LP7720-8
database_cross_reference: LNC:MTHU001946
database_cross_reference: LNC:MTHU051577
database_cross_reference: MDR:10047854
database_cross_reference: MDR:10047955
database_cross_reference: MSH:D007962
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000080
database_cross_reference: MTH:U000173
database_cross_reference: NCI:C12529
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044430
database_cross_reference: NCI_NCI-GLOSS:CDR0000045993
database_cross_reference: NCI_NCI-GLOSS:CDR0000046067
database_cross_reference: NDDF:007472
database_cross_reference: PSY:28250
database_cross_reference: PSY:28270
database_cross_reference: PSY:56680
database_cross_reference: RCD:X80Uw
database_cross_reference: SNM:T-05500
database_cross_reference: SNM:T-06460
database_cross_reference: SNM:T-0X140
database_cross_reference: SNMI:T-C1460
database_cross_reference: SNOMEDCT_US:272170001
database_cross_reference: SNOMEDCT_US:52501007

Granulocytes
type: Class
subclass of: Leukocytes
subclass of: Bone Marrow Cells
subclass of: Myeloid Cells
MCID: MC00005834
PMOID: PMO:00000577
Subclass_of: Bone Marrow Cells
Subclass_of: Leukocytes
Subclass_of: Myeloid Cells
Synonym: Blood granulocytic cell
Synonym: Granular Leukocyte
Synonym: Granular Leukocytes
Synonym: Granular leucocyte
Synonym: Granular leukocyte
Synonym: Granulocyte
Synonym: Granulocyte (body structure)
Synonym: Granulocyte (cell)
Synonym: Granulocytic
Synonym: Granulocytic Cell
Tree Number: T2.20.2
Tree Number: T2.4.4.1
Tree Number: T2.5.1
database_cross_reference: AOD:0000017463
database_cross_reference: AOD:0000027892
database_cross_reference: CHV:0000005683
database_cross_reference: CSP:0435-6075
database_cross_reference: FMA:62854
database_cross_reference: LCH:U002035
database_cross_reference: LCH_NW:sh85056441
database_cross_reference: LNC:LP133971-4
database_cross_reference: LNC:LP18643-4
database_cross_reference: LNC:MTHU008674
database_cross_reference: MSH:D006098
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000172
database_cross_reference: NCI:C12530
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046374
database_cross_reference: NCI_NCI-GLOSS:CDR0000633912
database_cross_reference: RCD:X79co
database_cross_reference: SNM:T-0X150
database_cross_reference: SNMI:T-C1210
database_cross_reference: SNOMEDCT_US:256909001
database_cross_reference: SNOMEDCT_US:48791004

Basophils
type: Class
subclass of: Granulocytes
MCID: MC00001520
PMOID: PMO:00000578
Subclass_of: Granulocytes
Synonym: Basophil
Synonym: Basophil leukocyte
Synonym: Basophil, segmented
Synonym: Basophil, segmented (cell)
Synonym: Basophilic Granulocyte
Synonym: Basophilic Leukocyte
Synonym: Blood basophil
Synonym: Marrow basophil
Synonym: basophil
Synonym: basophilic granulocyte
Tree Number: T2.20.2.1
Tree Number: T2.4.4.1.1
database_cross_reference: AOD:0000017469
database_cross_reference: AOD:0000027901
database_cross_reference: AOD:0000027902
database_cross_reference: CHV:0000001728
database_cross_reference: CSP:0435-5125
database_cross_reference: FMA:62862
database_cross_reference: LCH_NW:sh85012133
database_cross_reference: LNC:LP14328-6
database_cross_reference: LNC:LP21273-5
database_cross_reference: LNC:MTHU012774
database_cross_reference: MSH:D001491
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000170
database_cross_reference: NCI:C12531
database_cross_reference: NCI_NCI-GLOSS:CDR0000046517
database_cross_reference: RCD:X80VQ
database_cross_reference: SNM:T-06440
database_cross_reference: SNM:T-0X180
database_cross_reference: SNMI:T-C1440
database_cross_reference: SNOMEDCT_US:30061004

Eosinophils
type: Class
subclass of: Granulocytes
MCID: MC00004573
PMOID: PMO:00000579
Subclass_of: Granulocytes
Synonym: Acidophilic Leukocyte
Synonym: Blood Eosinophil
Synonym: Blood eosinophil
Synonym: Blood eosinophils
Synonym: Eosinocyte
Synonym: Eosinophil
Synonym: Eosinophil leucocyte
Synonym: Eosinophil leukocyte
Synonym: Eosinophil, segmented
Synonym: Eosinophil, segmented (cell)
Tree Number: T2.20.2.2
Tree Number: T2.4.4.1.2
database_cross_reference: AOD:0000017468
database_cross_reference: AOD:0000027898
database_cross_reference: AOD:0000027899
database_cross_reference: AOD:0000027900
database_cross_reference: CHV:0000004532
database_cross_reference: CSP:0435-5600
database_cross_reference: FMA:62861
database_cross_reference: LCH_NW:sh85044242
database_cross_reference: LNC:LA12895-1
database_cross_reference: LNC:LP14539-8
database_cross_reference: LNC:LP28567-3
database_cross_reference: LNC:MTHU009211
database_cross_reference: MDR:10005503
database_cross_reference: MDR:10014963
database_cross_reference: MSH:D004804
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000171
database_cross_reference: NCI:C12532
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044844
database_cross_reference: RCD:X80VM
database_cross_reference: SNM:T-06340
database_cross_reference: SNM:T-0X170
database_cross_reference: SNMI:T-C1340
database_cross_reference: SNOMEDCT_US:14793004

Neutrophils
type: Class
subclass of: Granulocytes
subclass of: Phagocytes
MCID: MC00008866
PMOID: PMO:00000580
Subclass_of: Granulocytes
Subclass_of: Phagocytes
Synonym: Blood PMN
Synonym: Blood Segmented Neutrophil
Synonym: Blood neutrophil
Synonym: Blood neutrophils
Synonym: Blood segmented neutrophil
Synonym: Heterophile leucocyte
Synonym: Leukocyte, Polymorphonuclear
Synonym: Leukocytes, Polymorphonuclear
Synonym: Marrow neutrophil
Synonym: Neutrophil
Tree Number: T2.20.2.3
Tree Number: T2.27.3
Tree Number: T2.4.4.1.3
database_cross_reference: AOD:0000017464
database_cross_reference: AOD:0000017466
database_cross_reference: AOD:0000027893
database_cross_reference: AOD:0000027895
database_cross_reference: CCPSS:0004906
database_cross_reference: CHV:0000008680
database_cross_reference: CHV:0000022380
database_cross_reference: CHV:0000049043
database_cross_reference: CSP:0435-6550
database_cross_reference: FMA:62860
database_cross_reference: LCH:U003211
database_cross_reference: LCH_NW:sh85091230
database_cross_reference: LNC:LP14267-6
database_cross_reference: LNC:LP16686-5
database_cross_reference: LNC:LP17840-7
database_cross_reference: LNC:MTHU006207
database_cross_reference: LNC:MTHU009212
database_cross_reference: LNC:MTHU044811
database_cross_reference: MDR:10005674
database_cross_reference: MDR:10029380
database_cross_reference: MSH:D009504
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000178
database_cross_reference: NCI:C12533
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046270
database_cross_reference: NCI_NCI-GLOSS:CDR0000633913
database_cross_reference: NCI_NCI-GLOSS:CDR0000633963
database_cross_reference: RCD:X80Ux
database_cross_reference: SNM:T-06260
database_cross_reference: SNM:T-0X160
database_cross_reference: SNMI:T-C1260
database_cross_reference: SNOMEDCT_US:116712007
database_cross_reference: SNOMEDCT_US:259710001
database_cross_reference: SNOMEDCT_US:80153006

Leukocytes, Mononuclear
type: Class
subclass of: Leukocytes
MCID: MC00007510
PMOID: PMO:00000581
Subclass_of: Leukocytes
Synonym: Agranular leukocyte
Synonym: Agranulocyte
Synonym: Leukocyte, Mononuclear
Synonym: Mononuclear Leukocyte
Synonym: Mononuclear Leukocytes
Synonym: Mononuclear leukocyte
Synonym: Non-Granular Leukocyte
Synonym: Non-Granular Leukocytes
Synonym: Nongranular leukocyte
Synonym: agranular leukocyte
Tree Number: T2.4.4.2
database_cross_reference: AOD:0000017471
database_cross_reference: AOD:0000027904
database_cross_reference: AOD:0000027906
database_cross_reference: CHV:0000007361
database_cross_reference: FMA:62855
database_cross_reference: MSH:D007963
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12534
database_cross_reference: NCI_NCI-GLOSS:CDR0000046207

Lymphocytes
type: Class
subclass of: Leukocytes, Mononuclear
MCID: MC00007747
PMOID: PMO:00000582
Subclass_of: Leukocytes, Mononuclear
Synonym: Blood lymphocyte
Synonym: Blood lymphocytic cell
Synonym: Lymph Cell
Synonym: Lymphocyte
Synonym: Lymphocyte (cell)
Synonym: Lymphocyte, NOS
Synonym: Lymphocytic
Synonym: Lymphocytic cell
Synonym: Lymphocytic cell, NOS
Synonym: Marrow lymphocyte
Tree Number: T2.4.4.2.1
database_cross_reference: AOD:0000002684
database_cross_reference: AOD:0000027925
database_cross_reference: CHV:0000007609
database_cross_reference: CSP:0435-7500
database_cross_reference: FMA:62863
database_cross_reference: LCH:U002760
database_cross_reference: LCH_NW:sh85079147
database_cross_reference: LNC:LP14540-6
database_cross_reference: LNC:LP30914-3
database_cross_reference: LNC:MTHU004645
database_cross_reference: MDR:10025263
database_cross_reference: MSH:D008214
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000176
database_cross_reference: NCI:C12535
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000045765
database_cross_reference: PSY:29060
database_cross_reference: RCD:X80V7
database_cross_reference: SNM:T-05230
database_cross_reference: SNM:T-06660
database_cross_reference: SNM:T-0X210
database_cross_reference: SNM:T-0X220
database_cross_reference: SNMI:T-C0230
database_cross_reference: SNOMEDCT_US:56972008

Precursor Cells, B-Lymphoid
type: Class
subclass of: Lymphoid Progenitor Cells
MCID: MC00524032
PMOID: PMO:00000583
Subclass_of: Lymphoid Progenitor Cells
Synonym: B Lymphoid Precursor Cells
Synonym: B-Cell, Immature
Synonym: B-Cell, Transitional
Synonym: B-Cells, Immature
Synonym: B-Cells, Transitional
Synonym: B-Lymphocyte, Immature
Synonym: B-Lymphocyte, Transitional
Synonym: B-Lymphocytes, Immature
Synonym: B-Lymphocytes, Transitional
Synonym: B-Lymphoid Precursor Cell
Tree Number: T2.34.2.3.1
Tree Number: T2.5.2.2.1
database_cross_reference: MEDCIN:12036
database_cross_reference: MSH:D054448
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32766

Precursor Cells, T-Lymphoid
type: Class
subclass of: Lymphoid Progenitor Cells
MCID: MC00628745
PMOID: PMO:00000599
Subclass_of: Lymphoid Progenitor Cells
Synonym: Cell, T-Lymphoid Precursor
Synonym: Cells, T-Lymphoid Precursor
Synonym: Precursor Cell, T-Lymphoid
Synonym: Precursor Cells, T Lymphoid
Synonym: Precursor, T-Cell
Synonym: Precursors, T-Cell
Synonym: T Cell Precursors
Synonym: T-Cell Precursor
Synonym: T-Cell Precursors
Synonym: T-Lymphoid Precursor Cell
Tree Number: T2.34.2.3.2
Tree Number: T2.5.2.2.2
database_cross_reference: MSH:D054504

Thymocytes
type: Class
subclass of: Cell
MCID: MC00277079
PMOID: PMO:00000600
Subclass_of: Cell
Synonym: Thymic lymphocyte
Synonym: Thymic lymphocyte (cell)
Synonym: Thymocyte
Synonym: thymocyte
Synonym: thymocytes
Tree Number: T2.35
database_cross_reference: AOD:0000017491
database_cross_reference: CHV:0000049345
database_cross_reference: CSP:0435-8450
database_cross_reference: FMA:72202
database_cross_reference: MSH:D060168
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12994
database_cross_reference: NCI_NCI-GLOSS:CDR0000633949
database_cross_reference: SNM:T-98070
database_cross_reference: SNMI:T-C8070
database_cross_reference: SNOMEDCT_US:39105001

Monocytes
type: Class
subclass of: Leukocytes, Mononuclear
subclass of: Bone Marrow Cells
subclass of: Myeloid Cells
subclass of: Phagocytes
MCID: MC00008393
PMOID: PMO:00000604
Subclass_of: Bone Marrow Cells
Subclass_of: Leukocytes, Mononuclear
Subclass_of: Myeloid Cells
Subclass_of: Phagocytes
Synonym: Blood monocyte
Synonym: Blood monocytes
Synonym: MONOCYTE
Synonym: Marrow monocyte
Synonym: Monocyte
Synonym: Monocyte (cell)
Synonym: Monocyte, NOS
Synonym: Monocytic
Synonym: blood monocytes
Synonym: monocyte
Tree Number: T2.20.4
Tree Number: T2.27.2
Tree Number: T2.4.4.2.2
Tree Number: T2.5.4
database_cross_reference: AOD:0000017472
database_cross_reference: CHV:0000008236
database_cross_reference: CSP:0435-8925
database_cross_reference: FMA:62864
database_cross_reference: LCH:U003015
database_cross_reference: LCH_NW:sh85086902
database_cross_reference: LNC:LP14313-8
database_cross_reference: LNC:LP32104-9
database_cross_reference: LNC:MTHU012776
database_cross_reference: MDR:10005667
database_cross_reference: MDR:10027884
database_cross_reference: MSH:D009000
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000177
database_cross_reference: NCI:C12547
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12547
database_cross_reference: NCI_NCI-GLOSS:CDR0000046282
database_cross_reference: RCD:X80VJ
database_cross_reference: SNM:T-05420
database_cross_reference: SNM:T-06700
database_cross_reference: SNM:T-0X290
database_cross_reference: SNMI:T-C1700
database_cross_reference: SNOMEDCT_US:55918008

Monocytes, Activated Killer
type: Class
subclass of: Monocytes
MCID: MC00041184
PMOID: PMO:00000605
Subclass_of: Monocytes
Synonym: AKM
Synonym: Activated Killer Monocyte
Synonym: Activated Killer Monocytes
Synonym: Killer Monocyte, Activated
Synonym: Killer Monocytes, Activated
Synonym: Monocyte, Activated Killer
Tree Number: T2.20.4.1
Tree Number: T2.27.2.1
database_cross_reference: MSH:D016260
database_cross_reference: NCI:C12548

Cytokine-Induced Killer Cells
type: Class
subclass of: Leukocytes, Mononuclear
subclass of: Cells, Cultured
MCID: MC00714328
PMOID: PMO:00000606
Subclass_of: Cells, Cultured
Subclass_of: Leukocytes, Mononuclear
Synonym: CIK
Synonym: CIK Cell
Synonym: CIK Cells
Synonym: Cytokine Induced Killer Cells
Synonym: Cytokine-Induced Killer Cell
Synonym: Killer Cell, Cytokine-Induced
Synonym: Killer Cells, Cytokine-Induced
Tree Number: T2.4.4.2.3
Tree Number: T2.6.6
database_cross_reference: MSH:D055612
database_cross_reference: NCI:C71757

Bone Marrow Cells
type: Class
subclass of: Cell
MCID: MC00001869
PMOID: PMO:00000607
Subclass_of: Cell
Synonym: Bone Marrow Blood-Forming Cell
Synonym: Bone Marrow Blood-Forming Cells
Synonym: Bone Marrow Cell
Synonym: Bone marrow cell
Synonym: Bone marrow cells
Synonym: Cell, Bone Marrow
Synonym: Cells, Bone Marrow
Synonym: Marrow Cell, Bone
Synonym: Marrow Cells, Bone
Synonym: bone cell marrow
Tree Number: T2.5
database_cross_reference: CHV:0000002073
database_cross_reference: FMA:83621
database_cross_reference: LCH_NW:sh85081545
database_cross_reference: MSH:D001854
database_cross_reference: NCI:C12550

Granulocyte Precursor Cells
type: Class
subclass of: Granulocytes
subclass of: Granulocyte-Macrophage Progenitor Cells
MCID: MC00421519
PMOID: PMO:00000608
Subclass_of: Granulocyte-Macrophage Progenitor Cells
Subclass_of: Granulocytes
Synonym: Cell, Granulocyte Precursor
Synonym: Cell, Granulocytic Precursor
Synonym: Cells, Granulocyte Precursor
Synonym: Cells, Granulocytic Precursor
Synonym: Granulocyte Precursor Cell
Synonym: Granulocytic Precursor Cell
Synonym: Granulocytic Precursor Cells
Synonym: Precursor Cell, Granulocyte
Synonym: Precursor Cell, Granulocytic
Synonym: Precursor Cells, Granulocyte
Tree Number: T2.20.2.4
Tree Number: T2.20.5.1.1
Tree Number: T2.5.1.1
database_cross_reference: MSH:D042381

Hematopoietic Stem Cells
type: Class
subclass of: Bone Marrow Cells
subclass of: Stem Cells
MCID: MC00006033
PMOID: PMO:00000609
Subclass_of: Bone Marrow Cells
Subclass_of: Stem Cells
Synonym: Blood-forming stem cell
Synonym: Cell, Hematopoietic Progenitor
Synonym: Cell, Hematopoietic Stem
Synonym: Cells, Hematopoietic Progenitor
Synonym: Cells, Hematopoietic Stem
Synonym: Ferrata cell
Synonym: HSC
Synonym: HSCs
Synonym: Haematopoietic stem cell
Synonym: Hematohistioblast
Tree Number: T2.34.2
Tree Number: T2.5.2
database_cross_reference: AOD:0000017480
database_cross_reference: CHV:0000005960
database_cross_reference: CHV:0000043661
database_cross_reference: CSP:0435-3857
database_cross_reference: CSP:4009-0065
database_cross_reference: FMA:86475
database_cross_reference: LCH:U002134
database_cross_reference: LCH_NW:sh85060138
database_cross_reference: LNC:LP149847-8
database_cross_reference: LNC:LP193444-9
database_cross_reference: LNC:MTHU044488
database_cross_reference: LNC:MTHU052722
database_cross_reference: MSH:D006412
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12551
database_cross_reference: NCI:TCGA
database_cross_reference: NDFRT:N0000184313
database_cross_reference: SNOMEDCT_US:418318001

Myeloid Progenitor Cells
type: Class
subclass of: Hematopoietic Stem Cells
subclass of: Myeloid Cells
MCID: MC00182859
PMOID: PMO:00000610
Subclass_of: Hematopoietic Stem Cells
Subclass_of: Myeloid Cells
Synonym: Bone Marrow Myeloid Stem Cell
Synonym: Cell, Myeloid Progenitor
Synonym: Cell, Myeloid Stem
Synonym: Cells, Myeloid Progenitor
Synonym: Cells, Myeloid Stem
Synonym: Myeloid Progenitor Cell
Synonym: Myeloid Stem Cell
Synonym: Myeloid Stem Cells
Synonym: Myeloid cell
Synonym: Myeloid stem cell
Tree Number: T2.20.5
Tree Number: T2.34.2.2
Tree Number: T2.5.2.1
database_cross_reference: CHV:0000041656
database_cross_reference: CSP:0435-9400
database_cross_reference: FMA:70339
database_cross_reference: MSH:D023461
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12552

Granulocyte-Macrophage Progenitor Cells
type: Class
subclass of: Myeloid Progenitor Cells
MCID: MC00715357
PMOID: PMO:00000611
Subclass_of: Myeloid Progenitor Cells
Synonym: Cell, Granulocyte-Macrophage Progenitor
Synonym: Cells, Granulocyte-Macrophage Progenitor
Synonym: Granulocyte Macrophage Progenitor Cell
Synonym: Granulocyte Macrophage Progenitor Cells
Synonym: Granulocyte Macrophage Progenitors
Synonym: Granulocyte-Macrophage Progenitor
Synonym: Granulocyte-Macrophage Progenitor Cell
Synonym: Granulocyte-Macrophage Progenitors
Synonym: Progenitor Cell, Granulocyte-Macrophage
Synonym: Progenitor Cells, Granulocyte Macrophage
Tree Number: T2.20.5.1
Tree Number: T2.34.2.2.1
Tree Number: T2.5.2.1.1
database_cross_reference: MSH:D055014

Monocyte-Macrophage Precursor Cells
type: Class
subclass of: Monocytes
subclass of: Granulocyte-Macrophage Progenitor Cells
subclass of: Macrophages
MCID: MC00715360
PMOID: PMO:00000612
Subclass_of: Granulocyte-Macrophage Progenitor Cells
Subclass_of: Macrophages
Subclass_of: Monocytes
Synonym: Cell, Monocyte-Macrophage Precursor
Synonym: Cells, Monocyte-Macrophage Precursor
Synonym: Monocyte Macrophage Precursor Cells
Synonym: Monocyte-Macrophage Precursor Cell
Synonym: Precursor Cell, Monocyte-Macrophage
Synonym: Precursor Cells, Monocyte-Macrophage
Tree Number: T2.20.3.10
Tree Number: T2.20.4.2
Tree Number: T2.20.5.1.2
Tree Number: T2.5.4.1
database_cross_reference: MSH:D055017

Megakaryocyte-Erythroid Progenitor Cells
type: Class
subclass of: Myeloid Progenitor Cells
MCID: MC00715358
PMOID: PMO:00000613
Subclass_of: Myeloid Progenitor Cells
Synonym: Cell, Megakaryocyte-Erythroid Progenitor
Synonym: Cells, Megakaryocyte-Erythroid Progenitor
Synonym: Megakaryocyte Erythrocyte Progenitors
Synonym: Megakaryocyte Erythroid Progenitor Cells
Synonym: Megakaryocyte Erythroid Progenitors
Synonym: Megakaryocyte-Erythrocyte Progenitor
Synonym: Megakaryocyte-Erythrocyte Progenitors
Synonym: Megakaryocyte-Erythroid Progenitor
Synonym: Megakaryocyte-Erythroid Progenitor Cell
Synonym: Megakaryocyte-Erythroid Progenitors
Tree Number: T2.34.2.2.2
Tree Number: T2.5.2.1.2
database_cross_reference: MSH:D055015

Erythroid Precursor Cells
type: Class
subclass of: Erythrocytes
MCID: MC00004688
PMOID: PMO:00000614
Subclass_of: Erythrocytes
Synonym: Cell, Erythroid Precursor
Synonym: Cells, Erythroid Precursor
Synonym: Erythroid Precursor Cell
Synonym: Erythroid precursor cell
Synonym: Erythroid precursor cell (body structure)
Synonym: Erythroid precursor cell (cell)
Synonym: Precursor Cell, Erythroid
Synonym: Precursor Cells, Erythroid
Synonym: Red blood cell precursor
Synonym: Red blood cell precursor (body structure)
Tree Number: T2.13.1.3
database_cross_reference: AOD:0000017450
database_cross_reference: CHV:0000043660
database_cross_reference: FMA:84774
database_cross_reference: MSH:D015672
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:XaA1Q
database_cross_reference: SNOMEDCT_US:127912006
database_cross_reference: SNOMEDCT_US:304601009

Erythroblasts
type: Class
subclass of: Erythroid Precursor Cells
MCID: MC00004674
PMOID: PMO:00000615
Subclass_of: Erythroid Precursor Cells
Synonym: Erythroblast
Synonym: Erythroblast (cell)
Synonym: Erythrocyte, Nucleated
Synonym: Erythrocytes, Nucleated
Synonym: Erythrocytes.nucleated
Synonym: NRBC - Nucleated red blood cell present
Synonym: NUCLEATED RED BLOOD CELLS
Synonym: NUCLEATED RED CELLS
Synonym: Normoblast
Synonym: Nucleated Erythrocyte
Tree Number: T2.13.1.3.1
database_cross_reference: CHV:0000004621
database_cross_reference: CSP:0435-0950
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002895
database_cross_reference: FMA:83504
database_cross_reference: LNC:LP14464-9
database_cross_reference: LNC:MTHU004246
database_cross_reference: MDR:10029825
database_cross_reference: MDR:10053106
database_cross_reference: MEDCIN:12048
database_cross_reference: MEDCIN:12056
database_cross_reference: MSH:D004900
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12527
database_cross_reference: NCI:C73125
database_cross_reference: RCD:X80Th
database_cross_reference: SNM:T-06110
database_cross_reference: SNMI:T-C1104
database_cross_reference: SNMI:T-C1110
database_cross_reference: SNMI:T-C1140
database_cross_reference: SNOMEDCT_US:29208003
database_cross_reference: SNOMEDCT_US:84227004

Lymphoid Progenitor Cells
type: Class
subclass of: Hematopoietic Stem Cells
MCID: MC00628743
PMOID: PMO:00000617
Subclass_of: Hematopoietic Stem Cells
Synonym: Cell, Lymphoid Progenitor
Synonym: Cell, Lymphoid Stem
Synonym: Cells, Lymphoid Progenitor
Synonym: Cells, Lymphoid Stem
Synonym: Lymphoid Progenitor Cell
Synonym: Lymphoid Stem Cell
Synonym: Lymphoid Stem Cells
Synonym: Lymphoid stem cell
Synonym: Progenitor Cell, Lymphoid
Synonym: Progenitor Cells, Lymphoid
Tree Number: T2.34.2.3
Tree Number: T2.5.2.2
database_cross_reference: FMA:70338
database_cross_reference: MSH:D054503

Megakaryocytes
type: Class
subclass of: Bone Marrow Cells
MCID: MC00007981
PMOID: PMO:00000618
Subclass_of: Bone Marrow Cells
Synonym: Blood megakaryocyte
Synonym: Megakaryocyte
Synonym: Megakaryocyte (cell)
Synonym: Megakaryocyte (substance)
Synonym: Megakaryocyte, NOS
Synonym: Megakaryocytic
Synonym: Megalokaryocyte
Synonym: megacaryocyte
Synonym: megakaryocyte
Synonym: megakaryocytes
Tree Number: T2.5.3
database_cross_reference: AOD:0000017476
database_cross_reference: AOD:0000027911
database_cross_reference: AOD:0000027912
database_cross_reference: AOD:0000027913
database_cross_reference: CHV:0000007883
database_cross_reference: CHV:0000057837
database_cross_reference: CSP:0432-7052
database_cross_reference: FMA:83555
database_cross_reference: LCH:U002883
database_cross_reference: LCH_NW:sh85083275
database_cross_reference: MSH:D008533
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12553
database_cross_reference: RCD:X80Vf
database_cross_reference: SNM:T-06540
database_cross_reference: SNM:T-0X320
database_cross_reference: SNMI:T-C1540
database_cross_reference: SNOMEDCT_US:23592000
database_cross_reference: SNOMEDCT_US:259728004

Endothelial Progenitor Cells
type: Class
subclass of: Bone Marrow Cells
subclass of: Endothelial Cells
MCID: MC00976437
PMOID: PMO:00000619
Subclass_of: Bone Marrow Cells
Subclass_of: Endothelial Cells
Synonym: Circulating Endothelial Progenitor Cells
Synonym: EPC
Synonym: Endothelial Progenitor Cell
Synonym: Endothelial Stem Cell
Synonym: Progenitor Cell, Endothelial
Synonym: Progenitor Cells, Endothelial
Tree Number: T2.12.27.4
Tree Number: T2.5.6
database_cross_reference: MSH:D066026
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124145

Cells, Cultured
type: Class
subclass of: Cell
MCID: MC00002460
PMOID: PMO:00000620
Subclass_of: Cell
Synonym: Cell Strain
Synonym: Cell, Cultured
Synonym: Cultured Cell
Synonym: Cultured Cells
Synonym: Cultured cells
Synonym: Cultured cells (substance)
Synonym: cell culturing
Synonym: cells cultured
Synonym: cultured cell
Synonym: cultured cells
Tree Number: T2.6
database_cross_reference: CHV:0000002604
database_cross_reference: MSH:D002478
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45382
database_cross_reference: NCI_NCI-GLOSS:CDR0000044017
database_cross_reference: SNOMEDCT_US:702451000

Cell Line
type: Class
subclass of: Cells, Cultured
MCID: MC00002443
PMOID: PMO:00000621
Subclass_of: Cells, Cultured
Synonym: Cell Lines
Synonym: Cell lines
Synonym: Cultured Cell Line
Synonym: Line, Cell
Synonym: Lines, Cell
Synonym: cell line
Synonym: cell lines
Synonym: cell lining
Synonym: cells line
Synonym: cells lines
Tree Number: T2.6.1
database_cross_reference: AOD:0000016692
database_cross_reference: CHV:0000002591
database_cross_reference: CSP:4000-0369
database_cross_reference: LCH:U000870
database_cross_reference: LCH_NW:sh85021651
database_cross_reference: MSH:D002460
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16403
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044016
database_cross_reference: NCI_NCI-GLOSS:CDR0000044017

Cell Line, Transformed
type: Class
subclass of: Cell Line
MCID: MC00002444
PMOID: PMO:00000622
Subclass_of: Cell Line
Synonym: Cell Lines, Transformed
Synonym: Transformed Cell Line
Synonym: Transformed Cell Lines
Tree Number: T2.6.1.1
database_cross_reference: MSH:D002461

RAW 264.7 Cells
type: Class
subclass of: Cell Line, Transformed
subclass of: Macrophages
MCID: MC01007821
PMOID: PMO:00000623
Subclass_of: Cell Line, Transformed
Subclass_of: Macrophages
Synonym: 264.7 Cell, RAW
Synonym: 264.7 Cells, RAW
Synonym: Cell, RAW 264.7
Synonym: Cells, RAW 264.7
Synonym: RAW 264.7 Cell
Synonym: RAW 264.7 Cell Line
Tree Number: T2.27.1.1
Tree Number: T2.6.1.1.1
database_cross_reference: MSH:D000067996

COS Cells
type: Class
subclass of: Cell Line, Transformed
subclass of: Fibroblasts
MCID: MC00133405
PMOID: PMO:00000624
Subclass_of: Cell Line, Transformed
Subclass_of: Fibroblasts
Synonym: COS Cell
Synonym: COS-1
Synonym: Cell, COS
Synonym: Cells, COS
Synonym: cos cell
Synonym: cos cells
Tree Number: T2.10.3.4
Tree Number: T2.6.1.1.2
database_cross_reference: CHV:0000031875
database_cross_reference: MSH:D019556
database_cross_reference: NCI:C17968

HEK293 Cells
type: Class
subclass of: Cell Line, Transformed
subclass of: Epithelial Cells
MCID: MC00797818
PMOID: PMO:00000625
Subclass_of: Cell Line, Transformed
Subclass_of: Epithelial Cells
Synonym: 293 Cell, HEK
Synonym: 293 Cells, HEK
Synonym: 293T Cell
Synonym: 293T Cells
Synonym: Cell, 293T
Synonym: Cell, HEK 293
Synonym: Cell, HEK293
Synonym: Cells, 293T
Synonym: Cells, HEK 293
Synonym: Cells, HEK293
Tree Number: T2.12.37
Tree Number: T2.6.1.1.3
database_cross_reference: MSH:D057809

L Cells (Cell Line)
type: Class
subclass of: Cell Line
subclass of: Fibroblasts
MCID: MC00007301
PMOID: PMO:00000626
Subclass_of: Cell Line
Subclass_of: Fibroblasts
Synonym: Cell, L (Cell Line)
Synonym: Cells, L (Cell Line)
Synonym: L Cell (Cell Line)
Synonym: L cell
Synonym: cell l
Synonym: l cells (cell line)
Tree Number: T2.10.3.2
Tree Number: T2.6.1.2
database_cross_reference: CHV:0000007146
database_cross_reference: CSP:2027-3178
database_cross_reference: MSH:D007739

Vero Cells
type: Class
subclass of: Cell Line
subclass of: Epithelial Cells
MCID: MC00013535
PMOID: PMO:00000627
Subclass_of: Cell Line
Subclass_of: Epithelial Cells
Synonym: Cell, Vero
Synonym: Cells, Vero
Synonym: Vero Cell
Synonym: Vero cell
Synonym: cells vero
Synonym: vero cell
Synonym: vero cells
Tree Number: T2.12.14
Tree Number: T2.6.1.3
database_cross_reference: CHV:0000012963
database_cross_reference: CSP:4008-0101
database_cross_reference: MSH:D014709

CHO Cells
type: Class
subclass of: Cell Line
subclass of: Epithelial Cells
PMOID: PMO:00000628
Subclass_of: Cell Line
Subclass_of: Epithelial Cells
Tree Number: T2.12.16
Tree Number: T2.6.1.4

3T3 Cells
type: Class
subclass of: Cell Line
subclass of: Fibroblasts
MCID: MC00043150
PMOID: PMO:00000629
Subclass_of: Cell Line
Subclass_of: Fibroblasts
Synonym: 3T3 Cell
Synonym: 3T3 cell
Synonym: Cell, 3T3
Synonym: Cells, 3T3
Synonym: T AAA A CELLS 03 03
Tree Number: T2.10.3.3
Tree Number: T2.6.1.5
database_cross_reference: AOD:0000016699
database_cross_reference: CSP:4001-0092
database_cross_reference: MSH:D016475

NIH 3T3 Cells
type: Class
subclass of: 3T3 Cells
MCID: MC00421496
PMOID: PMO:00000630
Subclass_of: 3T3 Cells
Synonym: 3T3 Cell, NIH
Synonym: 3T3 Cells, NIH
Synonym: Cell, NIH 3T3
Synonym: Cell, NIH-3T3
Synonym: Cells, NIH 3T3
Synonym: Cells, NIH-3T3
Synonym: NIH 3T3 Cell
Synonym: NIH T A CELLS 03 03
Synonym: NIH-3T3 Cell
Synonym: NIH-3T3 Cells
Tree Number: T2.10.3.3.1
Tree Number: T2.6.1.5.1
database_cross_reference: MSH:D041681
database_cross_reference: NCI:C17422

Swiss 3T3 Cells
type: Class
subclass of: 3T3 Cells
MCID: MC00421497
PMOID: PMO:00000631
Subclass_of: 3T3 Cells
Synonym: 3T3 Cells, Swiss
Synonym: 3T3 Swiss Albino
Synonym: 3T3-Swiss Albino
Synonym: Cells, Swiss 3T3
Synonym: SWISS T A CELLS 03 03
Tree Number: T2.10.3.3.2
Tree Number: T2.6.1.5.2
database_cross_reference: MSH:D041701

BALB 3T3 Cells
type: Class
subclass of: 3T3 Cells
MCID: MC00421498
PMOID: PMO:00000633
Subclass_of: 3T3 Cells
Synonym: 3T3 Cell, BALB
Synonym: 3T3 Cell, BALB-c
Synonym: 3T3 Cells, BALB
Synonym: 3T3 Cells, BALB-c
Synonym: BALB 3T3 Cell
Synonym: BALB T A CELLS 03 03
Synonym: BALB c 3T3 Cells
Synonym: BALB-3T3 Cell
Synonym: BALB-3T3 Cells
Synonym: BALB-c 3T3 Cell
Tree Number: T2.10.3.3.3
Tree Number: T2.6.1.5.3
database_cross_reference: MSH:D041702

LLC-PK1 Cells
type: Class
subclass of: Cell Line
subclass of: Epithelial Cells
MCID: MC00081699
PMOID: PMO:00000634
Subclass_of: Cell Line
Subclass_of: Epithelial Cells
Synonym: Cell, LLC-PK1
Synonym: Cells, LLC-PK1
Synonym: LLC PK1 Cells
Synonym: LLC-PK1 Cell
Tree Number: T2.12.17
Tree Number: T2.6.1.6
database_cross_reference: MSH:D018374

Cell Line, Tumor
type: Class
subclass of: Cell Line
subclass of: Tumor Cells, Cultured
MCID: MC00043503
PMOID: PMO:00000635
Subclass_of: Cell Line
Subclass_of: Tumor Cells, Cultured
Synonym: Cell Lines, Tumor
Synonym: Line, Tumor Cell
Synonym: Lines, Tumor Cell
Synonym: Tumor Cell Line
Synonym: Tumor Cell Lines
Synonym: tumor cell line
Synonym: tumor cell lines
Tree Number: T2.6.1.7
Tree Number: T2.6.4.1
database_cross_reference: AOD:0000016715
database_cross_reference: CHV:0000015815
database_cross_reference: MSH:D045744
database_cross_reference: NCI:C20313

A549 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Epithelial Cells
MCID: MC01054809
PMOID: PMO:00000636
Subclass_of: Cell Line, Tumor
Subclass_of: Epithelial Cells
Synonym: A549 Cell
Synonym: A549 Cell Line
Synonym: A549 Cell Lines
Synonym: Cell Line, A549
Synonym: Cell Lines, A549
Synonym: Cell, A549
Synonym: Cells, A549
Tree Number: T2.12.1
Tree Number: T2.6.1.7.1
Tree Number: T2.6.4.1.1
database_cross_reference: MSH:D000072283

THP-1 Cells
type: Class
subclass of: Cell Line, Tumor
PMOID: PMO:00000637
Subclass_of: Cell Line, Tumor
Tree Number: T2.6.1.7.2
Tree Number: T2.6.4.1.2

HeLa Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Epithelial Cells
MCID: MC00006004
PMOID: PMO:00000638
Subclass_of: Cell Line, Tumor
Subclass_of: Epithelial Cells
Synonym: Cell, HeLa
Synonym: Cells, HeLa
Synonym: HeLa
Synonym: HeLa Cell
Synonym: HeLa cell
Synonym: HeLa cells
Synonym: hela cell
Synonym: hela cells
Tree Number: T2.12.7
Tree Number: T2.6.1.7.3
Tree Number: T2.6.4.1.3
database_cross_reference: AOD:0000016717
database_cross_reference: CHV:0000005919
database_cross_reference: CSP:2027-2640
database_cross_reference: LCH:U002086
database_cross_reference: LCH_NW:sh85059978
database_cross_reference: MSH:D006367
database_cross_reference: NCI:C20226

KB Cells
type: Class
subclass of: HeLa Cells
MCID: MC00007185
PMOID: PMO:00000639
Subclass_of: HeLa Cells
Synonym: Cell, HeLa-KB
Synonym: Cell, KB
Synonym: Cells, HeLa-KB
Synonym: Cells, KB
Synonym: HeLa KB Cells
Synonym: HeLa-KB Cell
Synonym: HeLa-KB Cells
Synonym: KB Cell
Synonym: KB cell
Tree Number: T2.12.7.1
database_cross_reference: CSP:2935-5475
database_cross_reference: MSH:D007624

PC12 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Chromaffin Cells
MCID: MC00043243
PMOID: PMO:00000640
Subclass_of: Cell Line, Tumor
Subclass_of: Chromaffin Cells
Synonym: Cell Line, Pheochromocytoma
Synonym: Cell Lines, Pheochromocytoma
Synonym: PC A 012 CELLS
Synonym: PC-12
Synonym: PC12 Cell
Synonym: PC12 cell
Synonym: Pheochromocytoma 12 Cell Line
Synonym: Pheochromocytoma Cell Line
Synonym: Pheochromocytoma Cell Lines
Synonym: pc12 cell
Tree Number: T2.6.1.7.4
Tree Number: T2.6.4.1.4
Tree Number: T2.9.1
database_cross_reference: CHV:0000015524
database_cross_reference: CSP:4001-0103
database_cross_reference: MSH:D016716
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17435

HL-60 Cells
type: Class
subclass of: Granulocyte Precursor Cells
subclass of: Cell Line, Tumor
MCID: MC00098984
PMOID: PMO:00000641
Subclass_of: Cell Line, Tumor
Subclass_of: Granulocyte Precursor Cells
Synonym: Cell, HL60
Synonym: Cells, HL60
Synonym: HL 60 Cells
Synonym: HL CELLS 060
Synonym: HL-60 Cell
Synonym: HL60 Cell
Synonym: HL60 Cells
Synonym: hl-60 cells
Synonym: hl60 cells
Tree Number: T2.20.2.4.1
Tree Number: T2.6.1.7.5
Tree Number: T2.6.4.1.5
database_cross_reference: CHV:0000027639
database_cross_reference: MSH:D018922

Caco-2 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Epithelial Cells
MCID: MC00098994
PMOID: PMO:00000642
Subclass_of: Cell Line, Tumor
Subclass_of: Epithelial Cells
Synonym: CACO CELLS 002
Synonym: Caco 2 Cells
Synonym: Caco-2 Cell
Synonym: Cell, Caco-2
Synonym: Cells, Caco-2
Synonym: caco 2 cell
Synonym: caco 2 cells
Synonym: caco-2 cell
Tree Number: T2.12.19
Tree Number: T2.6.1.7.6
Tree Number: T2.6.4.1.6
database_cross_reference: CHV:0000027645
database_cross_reference: MSH:D018938
database_cross_reference: NCI:C12912

HT29 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Epithelial Cells
MCID: MC00099027
PMOID: PMO:00000643
Subclass_of: Cell Line, Tumor
Subclass_of: Epithelial Cells
Synonym: Cell, HT-29
Synonym: Cell, HT29
Synonym: Cells, HT-29
Synonym: Cells, HT29
Synonym: HT 29 CELLS
Synonym: HT 29 Cells
Synonym: HT-29
Synonym: HT-29 Cell
Synonym: HT-29 Cells
Synonym: HT29
Tree Number: T2.12.20
Tree Number: T2.6.1.7.7
Tree Number: T2.6.4.1.7
database_cross_reference: CHV:0000027678
database_cross_reference: MSH:D019073
database_cross_reference: NCI:C17896

Jurkat Cells
type: Class
subclass of: Cell Line, Tumor
MCID: MC00133341
PMOID: PMO:00000644
Subclass_of: Cell Line, Tumor
Synonym: Cell, Jurkat
Synonym: Cells, Jurkat
Synonym: Jurkat Cell
Synonym: Jurkat cell
Synonym: jurkat cells
Tree Number: T2.6.1.7.8
Tree Number: T2.6.4.1.8
database_cross_reference: CHV:0000031778
database_cross_reference: CSP:2935-5475
database_cross_reference: MSH:D019169

K562 Cells
type: Class
subclass of: Erythroid Precursor Cells
subclass of: Cell Line, Tumor
MCID: MC00184329
PMOID: PMO:00000645
Subclass_of: Cell Line, Tumor
Subclass_of: Erythroid Precursor Cells
Synonym: Cells, K562
Synonym: K A 562 CELLS
Tree Number: T2.13.1.3.2
Tree Number: T2.6.1.7.9
Tree Number: T2.6.4.1.9
database_cross_reference: MSH:D020014

U937 Cells
type: Class
subclass of: Monocyte-Macrophage Precursor Cells
subclass of: Cell Line, Tumor
MCID: MC00184376
PMOID: PMO:00000646
Subclass_of: Cell Line, Tumor
Subclass_of: Monocyte-Macrophage Precursor Cells
Synonym: Cell, U937
Synonym: Cells, U937
Synonym: U A 937 CELLS
Synonym: U937 Cell
Synonym: cells u937
Synonym: u937 cell
Synonym: u937 cells
Tree Number: T2.20.3.10.1
Tree Number: T2.20.4.2.1
Tree Number: T2.6.1.7.10
Tree Number: T2.6.4.1.10
database_cross_reference: CHV:0000042295
database_cross_reference: MSH:D020298

HCT116 Cells
type: Class
subclass of: Cell Line, Tumor
MCID: MC00421682
PMOID: PMO:00000647
Subclass_of: Cell Line, Tumor
Synonym: Cell, HCT 116
Synonym: Cell, HCT-116
Synonym: Cell, HCT116
Synonym: Cells, HCT 116
Synonym: Cells, HCT-116
Synonym: Cells, HCT116
Synonym: HCT 116 Cell
Synonym: HCT 116 Cells
Synonym: HCT-116 Cell
Synonym: HCT-116 Cells
Tree Number: T2.6.1.7.11
Tree Number: T2.6.4.1.11
database_cross_reference: MSH:D045325

MCF-7 Cells
type: Class
subclass of: Cell Line, Tumor
MCID: MC00182817
PMOID: PMO:00000648
Subclass_of: Cell Line, Tumor
Synonym: Cell, MCF-7
Synonym: Cell, MCF7
Synonym: Cells, MCF-7
Synonym: Cells, MCF7
Synonym: MCF 7 Cells
Synonym: MCF-7 Cell
Synonym: MCF7
Synonym: MCF7 Cell
Synonym: MCF7 Cells
Synonym: MCF7 cell
Tree Number: T2.6.1.7.12
database_cross_reference: CSP:4001-0077
database_cross_reference: MSH:D061986
database_cross_reference: NCI:C18096

Madin Darby Canine Kidney Cells
type: Class
subclass of: Cell Line
subclass of: Epithelial Cells
MCID: MC00183707
PMOID: PMO:00000649
Subclass_of: Cell Line
Subclass_of: Epithelial Cells
Synonym: Cell, MDCK
Synonym: Cells, MDCK
Synonym: MDCK Cell
Synonym: MDCK Cells
Synonym: MDCK cell
Synonym: Madin Darby canine kidney cell
Tree Number: T2.12.38
Tree Number: T2.6.1.8
database_cross_reference: CSP:4001-0078
database_cross_reference: MSH:D061985

Sf9 Cells
type: Class
subclass of: Cell Line
PMOID: PMO:00000650
Subclass_of: Cell Line
Tree Number: T2.6.1.9

Clone Cells
type: Class
subclass of: Cells, Cultured
MCID: MC00002969
PMOID: PMO:00000651
Subclass_of: Cells, Cultured
Synonym: Cell Clone
Synonym: Cell, Clone
Synonym: Cells, Clone
Synonym: Clone
Synonym: Clone (cell)
Synonym: Clone Cell
Synonym: Clone cells
Synonym: Clone, NOS
Synonym: Clones
Synonym: Cloning
Tree Number: T2.6.2
database_cross_reference: CHV:0000003056
database_cross_reference: CSP:2935-5444
database_cross_reference: CSP:2935-5475
database_cross_reference: CSP:4000-0369
database_cross_reference: LCH:U001055
database_cross_reference: LCH_NW:sh85027120
database_cross_reference: LCH_NW:sh85027122
database_cross_reference: MSH:D002999
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16441
database_cross_reference: SNM:F-40900
database_cross_reference: SNMI:F-C6300
database_cross_reference: SNOMEDCT_US:47308002

Hybridomas
type: Class
subclass of: Clone Cells
subclass of: Hybrid Cells
MCID: MC00006432
PMOID: PMO:00000652
Subclass_of: Clone Cells
Subclass_of: Hybrid Cells
Synonym: Hybridoma
Synonym: Hybridoma (cell)
Synonym: cell hybridoma
Synonym: hybridoma
Synonym: hybridomas
Tree Number: T2.6.2.1
Tree Number: T2.6.3.1
database_cross_reference: CHV:0000006326
database_cross_reference: CSP:0602-4228
database_cross_reference: LCH:U002263
database_cross_reference: LCH_NW:sh85063278
database_cross_reference: MSH:D006825
database_cross_reference: NCI:C16700
database_cross_reference: SNMI:F-C6410
database_cross_reference: SNOMEDCT_US:25326005

Hybrid Cells
type: Class
subclass of: Cells, Cultured
MCID: MC00006430
PMOID: PMO:00000653
Subclass_of: Cells, Cultured
Synonym: Cell Hybrid, Somatic
Synonym: Cell Hybrids, Somatic
Synonym: Cell, Hybrid
Synonym: Cells, Hybrid
Synonym: Hybrid Cell
Synonym: Hybrid, Somatic Cell
Synonym: Hybrids, Somatic Cell
Synonym: Somatic Cell Hybrid
Synonym: Somatic Cell Hybrids
Tree Number: T2.6.3
database_cross_reference: MSH:D006822
database_cross_reference: MTH:NOCODE

Tumor Cells, Cultured
type: Class
subclass of: Cells, Cultured
MCID: MC00013226
PMOID: PMO:00000654
Subclass_of: Cells, Cultured
Synonym: CULTURED NEOPL CELLS
Synonym: Cell, Cultured Neoplastic
Synonym: Cell, Cultured Tumor
Synonym: Cells, Cultured Neoplastic
Synonym: Cells, Cultured Tumor
Synonym: Cultured Neoplastic Cell
Synonym: Cultured Neoplastic Cells
Synonym: Cultured Tumor Cell
Synonym: Cultured Tumor Cells
Synonym: NEOPL CELLS CULTURED
Tree Number: T2.6.4
database_cross_reference: MSH:D014407

Hep G2 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Hepatocytes
MCID: MC00747821
PMOID: PMO:00000655
Subclass_of: Cell Line, Tumor
Subclass_of: Hepatocytes
Synonym: Cell Line, Hep G2
Synonym: Cell Line, Hepatoblastoma G2
Synonym: Cell, Hep G2
Synonym: Cell, HepG2
Synonym: Cells, Hep G2
Synonym: Cells, HepG2
Synonym: Hep G2 Cell
Synonym: Hep G2 Cell Line
Synonym: HepG2 Cell
Synonym: HepG2 Cells
Tree Number: T2.12.26.1
Tree Number: T2.6.4.1.12
database_cross_reference: MSH:D056945

Embryonal Carcinoma Stem Cells
type: Class
subclass of: Tumor Cells, Cultured
subclass of: Neoplastic Stem Cells
subclass of: Embryonic Stem Cells
MCID: MC00004276
PMOID: PMO:00000656
Subclass_of: Embryonic Stem Cells
Subclass_of: Neoplastic Stem Cells
Subclass_of: Tumor Cells, Cultured
Synonym: Carcinoma Cell, Embryonal
Synonym: Carcinoma Cells, Embryonal
Synonym: Cell, Embryonal Carcinoma
Synonym: Cell, Teratocarcinoma Stem
Synonym: Cells, Embryonal Carcinoma
Synonym: Cells, Teratocarcinoma Stem
Synonym: Embryonal Carcinoma Cell
Synonym: Embryonal Carcinoma Cells
Synonym: Stem Cell, Teratocarcinoma
Synonym: Stem Cells, Teratocarcinoma
Tree Number: T2.34.3.1
Tree Number: T2.34.7.1.5
Tree Number: T2.6.4.2
database_cross_reference: MSH:D054278

Spheroids, Cellular
type: Class
subclass of: Cells, Cultured
MCID: MC00098956
PMOID: PMO:00000657
Subclass_of: Cells, Cultured
Synonym: Cellular Spheroid
Synonym: Cellular Spheroids
Synonym: Multicellular Spheroid
Synonym: Multicellular Spheroids
Synonym: Spheroid, Cellular
Synonym: Spheroid, Multicellular
Synonym: Spheroids, Multicellular
Tree Number: T2.6.5
database_cross_reference: MSH:D018874

Feeder Cells
type: Class
subclass of: Cells, Cultured
MCID: MC00831138
PMOID: PMO:00000658
Subclass_of: Cells, Cultured
Synonym: Cell, Feeder
Synonym: Cells, Feeder
Tree Number: T2.6.7
database_cross_reference: MSH:D061252

Cells, Immobilized
type: Class
subclass of: Cell
MCID: MC00098980
PMOID: PMO:00000659
Subclass_of: Cell
Synonym: Cell, Immobilized
Synonym: Immobilized Cell
Synonym: Immobilized Cells
Synonym: Immobilized cells
Tree Number: T2.7
database_cross_reference: LCH_NW:sh85064524
database_cross_reference: MSH:D018914

Cellular Structures
type: Class
subclass of: Cell
MCID: MC00002459
PMOID: PMO:00000660
Subclass_of: Cell
Synonym: Cell
Synonym: Cell Type
Synonym: Cell Types
Synonym: Cell structure
Synonym: Cell structure (body structure)
Synonym: Cell structure (cell structure)
Synonym: Cell, NOS
Synonym: Cells
Synonym: Cells (Biology)
Synonym: Cells set
Tree Number: T2.8
database_cross_reference: CHV:0000002603
database_cross_reference: CSP:0605-5409
database_cross_reference: FMA:68646
database_cross_reference: FMA:71954
database_cross_reference: GO:GO:0005623
database_cross_reference: LCH:U000874
database_cross_reference: LCH_NW:sh85021678
database_cross_reference: LNC:LP14738-6
database_cross_reference: LNC:LP174115-8
database_cross_reference: LNC:MTHU001933
database_cross_reference: MSH:D002477
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12508
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046476
database_cross_reference: NCI_UCUM:C12508
database_cross_reference: PSY:08080
database_cross_reference: SNM:T-YX000
database_cross_reference: SNM:U000525
database_cross_reference: SNMI:T-E0000
database_cross_reference: SNOMEDCT_US:4421005
database_cross_reference: UWDA:68646
database_cross_reference: UWDA:71954

Chromaffin Cells
type: Class
subclass of: Cell
MCID: MC00133383
PMOID: PMO:00000661
Subclass_of: Cell
Synonym: Cell, Chromaffin
Synonym: Cells, Chromaffin
Synonym: Chromaffin Cell
Synonym: Chromaffin cell
Synonym: Chromaffin cells
Synonym: Phaeochromocyte
Synonym: Pheochromocyte
Synonym: chromaffin cell
Synonym: chromaffin cells
Tree Number: T2.9
database_cross_reference: CHV:0000031833
database_cross_reference: CSP:0605-5566
database_cross_reference: FMA:69263
database_cross_reference: LCH:U006354
database_cross_reference: LCH_NW:sh85025330
database_cross_reference: MSH:D019439
database_cross_reference: NCI:C12554
database_cross_reference: NCI_NCI-GLOSS:CDR0000537551
database_cross_reference: UWDA:69263

Connective Tissue Cells
type: Class
subclass of: Cell
MCID: MC00003210
PMOID: PMO:00000662
Subclass_of: Cell
Synonym: Cell of connective tissue
Synonym: Cell, Connective Tissue
Synonym: Cells, Connective Tissue
Synonym: Connective Tissue Cell
Synonym: Connective and Soft Tissue Cell
Synonym: Connective tissue cell
Synonym: Connective tissue cells
Synonym: cells connective tissue
Synonym: connective tissue cell
Synonym: connective tissue cells
Tree Number: T2.10
database_cross_reference: AOD:0000016852
database_cross_reference: CHV:0000003294
database_cross_reference: CSP:0729-6098
database_cross_reference: FMA:63875
database_cross_reference: LCH_NW:sh85031182
database_cross_reference: MSH:D003239
database_cross_reference: NCI:C12555
database_cross_reference: PSY:11320
database_cross_reference: UWDA:63875

Tenocytes
type: Class
subclass of: Connective Tissue Cells
MCID: MC01054894
PMOID: PMO:00000663
Subclass_of: Connective Tissue Cells
Synonym: Tenocyte
Tree Number: T2.10.1
database_cross_reference: MSH:D000070916

Synoviocytes
type: Class
subclass of: Connective Tissue Cells
MCID: MC00073065
PMOID: PMO:00000664
Subclass_of: Connective Tissue Cells
Synonym: Hyaluronic acid secreting cell
Synonym: Synovial Cell
Synonym: Synovial Cells
Synonym: Synovial cell
Synonym: Synovial cells
Synonym: Synoviocyte
Synonym: Synoviocytes (cell)
Synonym: synovial cell
Synonym: synoviocyte
Synonym: synoviocytes
Tree Number: T2.10.2
database_cross_reference: CHV:0000021806
database_cross_reference: FMA:66786
database_cross_reference: LNC:LP18365-4
database_cross_reference: LNC:MTHU004088
database_cross_reference: MSH:D000070918
database_cross_reference: NCI:C13059
database_cross_reference: SNM:T-1Y100
database_cross_reference: SNMI:T-15096
database_cross_reference: SNOMEDCT_US:76323008
database_cross_reference: UWDA:66786

Fibroblasts
type: Class
subclass of: Connective Tissue Cells
MCID: MC00005104
PMOID: PMO:00000665
Subclass_of: Connective Tissue Cells
Synonym: Fibroblast
Synonym: Fibroblast (cell)
Synonym: Fibroblasts [Chemical/Ingredient]
Synonym: cells fibroblast
Synonym: fibroblast
Synonym: fibroblast cell
Synonym: fibroblasts
Tree Number: T2.10.3
database_cross_reference: AOD:0000016706
database_cross_reference: CHV:0000005024
database_cross_reference: CSP:0729-6107
database_cross_reference: FMA:63877
database_cross_reference: LCH:U001783
database_cross_reference: LCH_NW:sh85048034
database_cross_reference: LNC:LP7234-0
database_cross_reference: LNC:MTHU010959
database_cross_reference: MSH:D005347
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12482
database_cross_reference: NCI_NCI-GLOSS:CDR0000044590
database_cross_reference: NDFRT:N0000184311
database_cross_reference: SNM:T-1X101
database_cross_reference: SNMI:T-1A101
database_cross_reference: SNOMEDCT_US:52547004
database_cross_reference: UWDA:63877

Cancer-Associated Fibroblasts
type: Class
subclass of: Fibroblasts
MCID: MC01054788
PMOID: PMO:00000666
Subclass_of: Fibroblasts
Synonym: Cancer Associated Fibroblast
Synonym: Cancer Associated Fibroblasts
Synonym: Cancer-Associated Fibroblast
Synonym: Fibroblast, Cancer Associated
Synonym: Fibroblast, Cancer-Associated
Synonym: Fibroblast, Tumor-Associated
Synonym: Fibroblasts, Cancer Associated
Synonym: Fibroblasts, Cancer-Associated
Synonym: Fibroblasts, Tumor-Associated
Synonym: Tumor Associated Fibroblasts
Tree Number: T2.10.3.1
database_cross_reference: MSH:D000072645

Mesangial Cells
type: Class
subclass of: Fibroblasts
MCID: MC00075394
PMOID: PMO:00000667
Subclass_of: Fibroblasts
Synonym: Cell, Kidney Mesangial
Synonym: Cell, Mesangial
Synonym: Cell, Renal Mesangial
Synonym: Cells, Kidney Mesangial
Synonym: Cells, Mesangial
Synonym: Cells, Renal Mesangial
Synonym: Glomerular mesangial cell
Synonym: Kidney Mesangial Cell
Synonym: Kidney Mesangial Cells
Synonym: Mesangial Cell
Tree Number: T2.10.3.5
database_cross_reference: CHV:0000022154
database_cross_reference: CSP:1681-3921
database_cross_reference: FMA:70972
database_cross_reference: MSH:D050527
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13159
database_cross_reference: SNM:T-71292
database_cross_reference: SNMI:T-71292
database_cross_reference: SNOMEDCT_US:24259000
database_cross_reference: UWDA:70972

Myofibroblasts
type: Class
subclass of: Fibroblasts
subclass of: Myocytes, Smooth Muscle
MCID: MC00073668
PMOID: PMO:00000668
Subclass_of: Fibroblasts
Subclass_of: Myocytes, Smooth Muscle
Synonym: Myofibroblast
Synonym: Myofibroblast (cell)
Synonym: myofibroblast
Synonym: myofibroblasts
Tree Number: T2.10.3.6
Tree Number: T2.19.3.1
database_cross_reference: CHV:0000021900
database_cross_reference: LCH_NW:sh99001909
database_cross_reference: MSH:D058628
database_cross_reference: NCI:C33153
database_cross_reference: SNM:T-1X350
database_cross_reference: SNMI:T-1A550
database_cross_reference: SNOMEDCT_US:56790003

Corneal Keratocytes
type: Class
subclass of: Fibroblasts
MCID: MC00831084
PMOID: PMO:00000669
Subclass_of: Fibroblasts
Synonym: Corneal Keratocyte
Synonym: Keratocyte, Corneal
Synonym: Keratocytes, Corneal
Tree Number: T2.10.3.7
database_cross_reference: MSH:D060527

Macrophages
type: Class
subclass of: Connective Tissue Cells
subclass of: Myeloid Cells
subclass of: Phagocytes
MCID: MC00007805
PMOID: PMO:00000670
Subclass_of: Connective Tissue Cells
Subclass_of: Myeloid Cells
Subclass_of: Phagocytes
Synonym: Bone Marrow Derived Macrophages
Synonym: Bone Marrow-Derived Macrophage
Synonym: Bone Marrow-Derived Macrophages
Synonym: Clasmatocyte
Synonym: Macrophage
Synonym: Macrophage (cell)
Synonym: Macrophage, Bone Marrow-Derived
Synonym: Macrophage, Monocyte-Derived
Synonym: Macrophages, Bone Marrow-Derived
Synonym: Macrophages, Monocyte Derived
Tree Number: T2.10.4
Tree Number: T2.20.3
Tree Number: T2.27.1
database_cross_reference: AOD:0000017509
database_cross_reference: CHV:0000007648
database_cross_reference: CSP:0432-6461
database_cross_reference: FMA:63261
database_cross_reference: LCH:U002774
database_cross_reference: LCH_NW:sh85079451
database_cross_reference: LNC:LP14314-6
database_cross_reference: LNC:MTHU016340
database_cross_reference: MSH:D008264
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12558
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044054
database_cross_reference: SNM:T-05128
database_cross_reference: SNMI:T-C0128
database_cross_reference: SNOMEDCT_US:58986001

Foam Cells
type: Class
subclass of: Macrophages
MCID: MC00005225
PMOID: PMO:00000671
Subclass_of: Macrophages
Synonym: Cell, Foam
Synonym: Cells, Foam
Synonym: Foam Cell
Synonym: Foam cell
Synonym: Foam cell (body structure)
Synonym: Foam cell (cell)
Synonym: Foam cells
Synonym: Foamy Macrophage
Synonym: Foamy histiocytes
Synonym: Foamy macrophages
Tree Number: T2.10.4.1
Tree Number: T2.20.3.1
Tree Number: T2.27.1.2
database_cross_reference: CHV:0000005142
database_cross_reference: CSP:0432-6461
database_cross_reference: FMA:83586
database_cross_reference: HPO:HP:0003651
database_cross_reference: MSH:D005487
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12560
database_cross_reference: OMIM:MTHU054378
database_cross_reference: SNM:M-69520
database_cross_reference: SNMI:M-62030
database_cross_reference: SNOMEDCT_US:16980002

Histiocytes
type: Class
subclass of: Macrophages
MCID: MC00006298
PMOID: PMO:00000672
Subclass_of: Macrophages
Synonym: Connective tissue macrophage
Synonym: Fixed Macrophage
Synonym: Fixed macrophage
Synonym: Histiocyte
Synonym: Histiocyte, NOS
Synonym: Histocyte
Synonym: Histocyte, NOS
Synonym: Resident tissue macrophage
Synonym: Resident tissue macrophage (cell)
Synonym: Tissue macrophage
Tree Number: T2.10.4.2
Tree Number: T2.20.3.2
Tree Number: T2.27.1.3
database_cross_reference: AOD:0000017512
database_cross_reference: CHV:0000006163
database_cross_reference: CSP:0432-6461
database_cross_reference: FMA:83585
database_cross_reference: FMA:84642
database_cross_reference: LNC:LA12897-7
database_cross_reference: LNC:LP18378-7
database_cross_reference: LNC:MTHU004278
database_cross_reference: MSH:D006644
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12563
database_cross_reference: SNM:T-05120
database_cross_reference: SNMI:T-C0120
database_cross_reference: SNOMEDCT_US:14295007

Kupffer Cells
type: Class
subclass of: Macrophages
MCID: MC00007289
PMOID: PMO:00000673
Subclass_of: Macrophages
Synonym: Cells, Kupffer
Synonym: Hepatic macrophage
Synonym: Hepatic sinusoidal macrophage
Synonym: Hepatic stellate cell
Synonym: Kupffer Cell
Synonym: Kupffer cell
Synonym: Kupffer cell (body structure)
Synonym: Kupffer cell (cell)
Synonym: Kupffer cells
Synonym: Kupffer's Cell
Tree Number: T2.10.4.3
Tree Number: T2.20.3.3
Tree Number: T2.27.1.4
database_cross_reference: AOD:0000017322
database_cross_reference: CHV:0000007138
database_cross_reference: CSP:1754-0982
database_cross_reference: FMA:14656
database_cross_reference: LCH:U002593
database_cross_reference: LCH_NW:sh85073457
database_cross_reference: MSH:D007728
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12564
database_cross_reference: SNM:T-56250
database_cross_reference: SNMI:T-62250
database_cross_reference: SNOMEDCT_US:256002
database_cross_reference: SNOMEDCT_VET:256002

Osteoclasts
type: Class
subclass of: Macrophages
MCID: MC00009287
PMOID: PMO:00000674
Subclass_of: Macrophages
Synonym: Osteoclast
Synonym: Osteoclast (cell)
Synonym: osteoclast
Synonym: osteoclasts
Tree Number: T2.10.4.4
Tree Number: T2.20.3.4
database_cross_reference: AOD:0000016872
database_cross_reference: CHV:0000009079
database_cross_reference: CSP:2715-3929
database_cross_reference: FMA:66781
database_cross_reference: LCH_NW:sh90003255
database_cross_reference: MSH:D010010
database_cross_reference: NCI:C12570
database_cross_reference: SNM:T-1X586
database_cross_reference: SNMI:T-11064
database_cross_reference: SNOMEDCT_US:27770000
database_cross_reference: UWDA:66781

Epithelioid Cells
type: Class
subclass of: Macrophages
MCID: MC00004627
PMOID: PMO:00000675
Subclass_of: Macrophages
Synonym: Cell, Epithelioid
Synonym: Cells, Epithelioid
Synonym: Epithelioid Cell
Synonym: Epithelioid cell
Synonym: epithelioid cell
Synonym: epithelioid cells
Tree Number: T2.10.4.5
Tree Number: T2.20.3.5
Tree Number: T2.27.1.5
database_cross_reference: CHV:0000004579
database_cross_reference: FMA:83514
database_cross_reference: MSH:D015622
database_cross_reference: NCI:C12559

Giant Cells, Foreign-Body
type: Class
subclass of: Macrophages
subclass of: Giant Cells
MCID: MC00005595
PMOID: PMO:00000676
Subclass_of: Giant Cells
Subclass_of: Macrophages
Synonym: Cell, Foreign-Body Giant
Synonym: Cells, Foreign-Body Giant
Synonym: Foreign Body Giant Cell
Synonym: Foreign Body Giant Cells
Synonym: Foreign Body Type Giant Cells
Synonym: Foreign Body-Type Giant Cells
Synonym: Foreign body giant cell
Synonym: Foreign body giant cell (body structure)
Synonym: Foreign body giant cell (cell)
Synonym: Foreign body giant cell, NOS
Tree Number: T2.10.4.6
Tree Number: T2.16.1
Tree Number: T2.20.3.6
Tree Number: T2.27.1.6
database_cross_reference: CHV:0000005485
database_cross_reference: MSH:D015743
database_cross_reference: NCI:C12561
database_cross_reference: SNMI:M-62510
database_cross_reference: SNOMEDCT_US:21386001

Giant Cells, Langhans
type: Class
subclass of: Macrophages
subclass of: Giant Cells
MCID: MC00005596
PMOID: PMO:00000677
Subclass_of: Giant Cells
Subclass_of: Macrophages
Synonym: Cells, Langhans Giant
Synonym: Cells, Langhans-Type Giant
Synonym: Giant Cells, Langhans-Type
Synonym: Langhans Cell
Synonym: Langhans Giant Cells
Synonym: Langhans Type Giant Cells
Synonym: Langhans giant cell
Synonym: Langhans giant cell (body structure)
Synonym: Langhans giant cell (cell)
Synonym: Langhans' - Type Giant Cell
Tree Number: T2.10.4.7
Tree Number: T2.16.2
Tree Number: T2.20.3.7
Tree Number: T2.27.1.7
database_cross_reference: MSH:D015744
database_cross_reference: NCI:C12562
database_cross_reference: SNMI:M-62530
database_cross_reference: SNOMEDCT_US:30938003

Macrophages, Alveolar
type: Class
subclass of: Macrophages
MCID: MC00043223
PMOID: PMO:00000678
Subclass_of: Macrophages
Synonym: Alveolar Macrophage
Synonym: Alveolar Macrophages
Synonym: Alveolar macrophage
Synonym: Alveolar macrophage (cell)
Synonym: MACROPHAGE PULM
Synonym: MACROPHAGES PULM
Synonym: Macrophage, Alveolar
Synonym: Macrophage, Pulmonary
Synonym: Macrophages, Pulmonary
Synonym: PULM MACROPHAGE
Tree Number: T2.10.4.8
Tree Number: T2.20.3.8
Tree Number: T2.27.1.8
database_cross_reference: CHV:0000015511
database_cross_reference: CSP:2612-1304
database_cross_reference: FMA:83023
database_cross_reference: MSH:D016676
database_cross_reference: NCI:C12565
database_cross_reference: SNMI:T-28053
database_cross_reference: SNOMEDCT_US:33956004

Macrophages, Peritoneal
type: Class
subclass of: Macrophages
MCID: MC00067335
PMOID: PMO:00000679
Subclass_of: Macrophages
Synonym: Macrophage, Peritoneal
Synonym: Peritoneal Macrophage
Synonym: Peritoneal Macrophages
Synonym: Peritoneal macrophage
Synonym: peritoneal macrophage
Synonym: peritoneal macrophages
Tree Number: T2.10.4.9
Tree Number: T2.20.3.9
Tree Number: T2.27.1.9
database_cross_reference: CHV:0000020854
database_cross_reference: FMA:83025
database_cross_reference: MSH:D017737
database_cross_reference: NCI:C12566

Mast Cells
type: Class
subclass of: Connective Tissue Cells
MCID: MC00007916
PMOID: PMO:00000680
Subclass_of: Connective Tissue Cells
Synonym: Basophil, Tissue
Synonym: Basophilic histiocyte
Synonym: Basophils, Tissue
Synonym: Cell, Mast
Synonym: Cells, Mast
Synonym: Histaminocyte
Synonym: Marrow mast cell
Synonym: Mast Cell
Synonym: Mast cell
Synonym: Mast cell (body structure)
Tree Number: T2.10.5
database_cross_reference: CHV:0000007777
database_cross_reference: CSP:0605-5591
database_cross_reference: FMA:66784
database_cross_reference: LCH:U002830
database_cross_reference: LCH_NW:sh85081982
database_cross_reference: LNC:LP15073-7
database_cross_reference: MSH:D008407
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12747
database_cross_reference: NCI_NCI-GLOSS:CDR0000044845
database_cross_reference: SNM:T-05140
database_cross_reference: SNM:T-06570
database_cross_reference: SNMI:T-C0140
database_cross_reference: SNOMEDCT_US:6445007
database_cross_reference: UWDA:66784

Odontoblasts
type: Class
subclass of: Connective Tissue Cells
MCID: MC00009118
PMOID: PMO:00000681
Subclass_of: Connective Tissue Cells
Synonym: Odontoblast
Synonym: odontoblast
Synonym: odontoblasts
Tree Number: T2.10.6
database_cross_reference: CHV:0000008905
database_cross_reference: CSP:0837-0437
database_cross_reference: FMA:62999
database_cross_reference: MSH:D009804
database_cross_reference: NCI:C12567
database_cross_reference: UWDA:62999

Osteoblasts
type: Class
subclass of: Connective Tissue Cells
MCID: MC00009279
PMOID: PMO:00000682
Subclass_of: Connective Tissue Cells
Synonym: Osteoblast
Synonym: Osteoblast (cell)
Synonym: cells osteoblast
Synonym: cells osteoblasts
Synonym: osteoblast
Synonym: osteoblasts
Tree Number: T2.10.7
database_cross_reference: AOD:0000016871
database_cross_reference: CHV:0000009072
database_cross_reference: CSP:2715-3886
database_cross_reference: FMA:66780
database_cross_reference: LCH_NW:sh2012001687
database_cross_reference: LNC:LP96511-8
database_cross_reference: MSH:D010006
database_cross_reference: NCI:C12568
database_cross_reference: SNM:T-1X582
database_cross_reference: SNMI:T-11062
database_cross_reference: SNOMEDCT_US:48156001
database_cross_reference: UWDA:66780

Osteocytes
type: Class
subclass of: Osteoblasts
MCID: MC00009288
PMOID: PMO:00000683
Subclass_of: Osteoblasts
Synonym: Bone cell
Synonym: Osteocyte
Synonym: Osteocyte (cell)
Synonym: osteocyte
Synonym: osteocytes
Tree Number: T2.10.7.1
database_cross_reference: CHV:0000009080
database_cross_reference: CSP:2715-3843
database_cross_reference: FMA:66779
database_cross_reference: LCH_NW:sh91003881
database_cross_reference: MSH:D010011
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12569
database_cross_reference: SNM:T-1X583
database_cross_reference: SNMI:T-11063
database_cross_reference: SNOMEDCT_US:23821005
database_cross_reference: UWDA:66779

Theca Cells
type: Class
subclass of: Connective Tissue Cells
MCID: MC00012690
PMOID: PMO:00000684
Subclass_of: Connective Tissue Cells
Synonym: Cell, Ovarian Interstitial
Synonym: Cell, Theca
Synonym: Cells, Ovarian Interstitial
Synonym: Cells, Theca
Synonym: Endocrinocytus interstitialis (Ovarium)
Synonym: Interstitial Cell, Ovarian
Synonym: Interstitial Cells, Ovarian
Synonym: Interstitial cell of ovary
Synonym: Ovarian Interstitial Cell
Synonym: Ovarian Interstitial Cells
Tree Number: T2.10.8
database_cross_reference: CHV:0000012153
database_cross_reference: CSP:2587-4290
database_cross_reference: FMA:18709
database_cross_reference: MSH:D013799
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12572
database_cross_reference: UWDA:18709

Stromal Cells
type: Class
subclass of: Connective Tissue Cells
MCID: MC00063342
PMOID: PMO:00000685
Subclass_of: Connective Tissue Cells
Synonym: Cell, Stromal
Synonym: Cells, Stromal
Synonym: Stromal Cell
Synonym: Stromal cell
Synonym: stromal cell
Synonym: stromal cells
Tree Number: T2.10.9
database_cross_reference: CHV:0000017910
database_cross_reference: CSP:0594-0219
database_cross_reference: FMA:83624
database_cross_reference: MSH:D017154
database_cross_reference: NCI:C12571
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000559134

Telocytes
type: Class
subclass of: Stromal Cells
MCID: MC00747800
PMOID: PMO:00000686
Subclass_of: Stromal Cells
Synonym: Cajal-Like Cells, Interstitial
Synonym: Cells, Interstitial Cajal-Like
Synonym: Interstitial Cajal Like Cells
Synonym: Interstitial Cajal-Like Cells
Synonym: Interstitial Cell of Cajal Like Cells
Synonym: Interstitial Cell of Cajal-Like Cells
Synonym: Telocyte
Tree Number: T2.10.9.1
database_cross_reference: MSH:D000067170

Mesenchymal Stromal Cells
type: Class
subclass of: Stromal Cells
subclass of: Multipotent Stem Cells
MCID: MC00831018
PMOID: PMO:00000687
Subclass_of: Multipotent Stem Cells
Subclass_of: Stromal Cells
Synonym: Cell, Mesenchymal Stromal
Synonym: Cells, Mesenchymal Stromal
Synonym: Mesenchymal Stromal Cell
Synonym: Stromal Cell, Mesenchymal
Synonym: Stromal Cells, Mesenchymal
Tree Number: T2.10.9.2
Tree Number: T2.34.6.1
database_cross_reference: MSH:D059630

Adipocytes
type: Class
subclass of: Connective Tissue Cells
MCID: MC00067310
PMOID: PMO:00000688
Subclass_of: Connective Tissue Cells
Synonym: Adipocyte
Synonym: Adipocyte (cell)
Synonym: Adipose Cell
Synonym: Adipose cell
Synonym: Cell, Fat
Synonym: Cells, Fat
Synonym: Fat Cell
Synonym: Fat Cells
Synonym: Fat cell
Synonym: Fat cells
Tree Number: T2.10.10
database_cross_reference: AOD:0000016855
database_cross_reference: AOD:0000027612
database_cross_reference: AOD:0000027613
database_cross_reference: CHV:0000020815
database_cross_reference: CSP:0729-5644
database_cross_reference: FMA:63880
database_cross_reference: LCH_NW:sh86006585
database_cross_reference: MSH:D017667
database_cross_reference: NCI:C12556
database_cross_reference: NCI:C32991
database_cross_reference: SNM:T-1X013
database_cross_reference: SNMI:T-1A013
database_cross_reference: SNOMEDCT_US:24826007
database_cross_reference: UWDA:63880

Adipocytes, Beige
type: Class
subclass of: Adipocytes
MCID: MC01054876
PMOID: PMO:00000689
Subclass_of: Adipocytes
Synonym: Adipocyte, Beige
Synonym: Adipocyte, Beige Brite
Synonym: Adipocyte, Brite
Synonym: Adipocytes, Beige Brite
Synonym: Adipocytes, Brite
Synonym: Beige Adipocyte
Synonym: Beige Adipocytes
Synonym: Beige Brite Adipocyte
Synonym: Beige Brite Adipocytes
Synonym: Beige Brite Cell
Tree Number: T2.10.10.1
database_cross_reference: MSH:D000069797

Adipocytes, Brown
type: Class
subclass of: Adipocytes
MCID: MC00583096
PMOID: PMO:00000690
Subclass_of: Adipocytes
Synonym: Adipocyte, Brown
Synonym: Brown Adipocyte
Synonym: Brown Adipocytes
Synonym: Brown Fat Cell
Synonym: Brown Fat Cells
Synonym: Brown adipocyte
Synonym: Brown adipose cell
Synonym: Brown fat cell
Synonym: Cell, Brown Fat
Synonym: Cells, Brown Fat
Tree Number: T2.10.10.2
database_cross_reference: FMA:83435
database_cross_reference: MSH:D052437

Adipocytes, White
type: Class
subclass of: Adipocytes
MCID: MC00583097
PMOID: PMO:00000691
Subclass_of: Adipocytes
Synonym: Adipocyte, White
Synonym: Cell, White Fat
Synonym: Cells, White Fat
Synonym: Fat Cell, White
Synonym: Fat Cells, White
Synonym: White Adipocyte
Synonym: White Adipocytes
Synonym: White Fat Cell
Synonym: White Fat Cells
Synonym: White adipocyte
Tree Number: T2.10.10.3
database_cross_reference: FMA:83434
database_cross_reference: MSH:D052438

Chondrocytes
type: Class
subclass of: Connective Tissue Cells
MCID: MC00073676
PMOID: PMO:00000692
Subclass_of: Connective Tissue Cells
Synonym: Cartilage cell
Synonym: Cartilage cell, NOS
Synonym: Chondrocyte
Synonym: Chondrocyte (cell)
Synonym: Chondrocyte (substance)
Synonym: Chondrocyte cell
Synonym: Chondrocyte cell (substance)
Synonym: Chondrocytes [Chemical/Ingredient]
Synonym: cartilage cell
Synonym: chondrocyte
Tree Number: T2.10.11
database_cross_reference: AOD:0000016869
database_cross_reference: AOD:0000027617
database_cross_reference: CHV:0000021903
database_cross_reference: CSP:2715-4316
database_cross_reference: FMA:66782
database_cross_reference: MSH:D019902
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12557
database_cross_reference: NCI_NCI-GLOSS:CDR0000044191
database_cross_reference: NDFRT:N0000184995
database_cross_reference: SNM:T-1X741
database_cross_reference: SNM:T-1X743
database_cross_reference: SNMI:T-1A741
database_cross_reference: SNMI:T-1A743
database_cross_reference: SNOMEDCT_US:429351002
database_cross_reference: SNOMEDCT_US:433180002
database_cross_reference: SNOMEDCT_US:81272008
database_cross_reference: UWDA:66782

Endocrine Cells
type: Class
subclass of: Cell
MCID: MC00076849
PMOID: PMO:00000693
Subclass_of: Cell
Synonym: Cell, Endocrine
Synonym: Cells, Endocrine
Synonym: Endocrine Cell
Synonym: Endocrine cell
Synonym: Endocrine cell (body structure)
Synonym: Endocrine cell (cell)
Synonym: Endocrine cell, NOS
Synonym: cells endocrine
Synonym: endocrine cell
Tree Number: T2.11
database_cross_reference: CHV:0000022358
database_cross_reference: FMA:83809
database_cross_reference: MSH:D055098
database_cross_reference: NCI:C32506
database_cross_reference: SNM:T-90160
database_cross_reference: SNMI:T-B0160
database_cross_reference: SNOMEDCT_US:68233007

APUD Cells
type: Class
subclass of: Endocrine Cells
MCID: MC00001188
PMOID: PMO:00000694
Subclass_of: Endocrine Cells
Synonym: APUD Cell
Synonym: APUD cell
Synonym: APUD cell group
Synonym: Amine Precursor Uptake and Decarboxylation Cells
Synonym: Amine precursor uptake and decarboxylation cell
Synonym: Amine precursor uptake and decarboxylation cell group
Synonym: Cell, APUD
Synonym: Cells, APUD
Synonym: Set of APUD cells
Synonym: apud cell
Tree Number: T2.11.1
database_cross_reference: CHV:0000001403
database_cross_reference: FMA:68651
database_cross_reference: FMA:83114
database_cross_reference: MSH:D001078
database_cross_reference: NCI:C12655
database_cross_reference: UWDA:68651

Granulosa Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00005847
PMOID: PMO:00000695
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cell, Granulosa
Synonym: Cells, Granulosa
Synonym: Granulosa Cell
Synonym: Granulosa cell
Synonym: Granulosa cell of ovary
Synonym: Ovarian Granulosa Cell
Synonym: cells granulosa
Synonym: granulosa cell
Synonym: granulosa cells
Tree Number: T2.11.2
Tree Number: T2.12.6
database_cross_reference: CHV:0000005694
database_cross_reference: CSP:2587-4310
database_cross_reference: FMA:18718
database_cross_reference: MSH:D006107
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12587
database_cross_reference: NCI:C41607
database_cross_reference: UWDA:18718

Cumulus Cells
type: Class
subclass of: Granulosa Cells
MCID: MC00628847
PMOID: PMO:00000696
Subclass_of: Granulosa Cells
Synonym: Cell, Cumulus
Synonym: Cell, Cumulus Granulosa
Synonym: Cells, Cumulus
Synonym: Cells, Cumulus Granulosa
Synonym: Cumulus Cell
Synonym: Cumulus Granulosa Cell
Synonym: Cumulus Granulosa Cells
Synonym: Granulosa Cell, Cumulus
Synonym: Granulosa Cells, Cumulus
Tree Number: T2.11.2.1
Tree Number: T2.12.6.1
database_cross_reference: MSH:D054885

Leydig Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00007547
PMOID: PMO:00000697
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cell, Testicular Interstitial
Synonym: Cells, Leydig
Synonym: Cells, Testicular Interstitial
Synonym: Interstitial Cell of Testis
Synonym: Interstitial Cell of the Testis
Synonym: Interstitial Cell, Testicular
Synonym: Interstitial Cells, Testicular
Synonym: Interstitial cell of Leydig
Synonym: Leydig Cell
Synonym: Leydig cell
Tree Number: T2.11.3
Tree Number: T2.12.9
database_cross_reference: AOD:0000017428
database_cross_reference: AOD:0000027854
database_cross_reference: AOD:0000027856
database_cross_reference: CHV:0000007381
database_cross_reference: CSP:2587-5718
database_cross_reference: FMA:72297
database_cross_reference: LCH:U002674
database_cross_reference: LCH_NW:sh85076366
database_cross_reference: MSH:D007985
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12609
database_cross_reference: SNM:T-78210
database_cross_reference: SNMI:T-94210
database_cross_reference: SNOMEDCT_US:44185004

Luteal Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00007717
PMOID: PMO:00000698
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cell, Luteal
Synonym: Cell, Lutein
Synonym: Cells, Luteal
Synonym: Cells, Lutein
Synonym: Luteal Cell
Synonym: Luteal cell
Synonym: Lutein Cell
Synonym: Lutein Cells
Synonym: Lutein cell
Synonym: luteal cell
Tree Number: T2.11.4
Tree Number: T2.12.10
database_cross_reference: AOD:0000017400
database_cross_reference: FMA:18688
database_cross_reference: MSH:D008184
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12610
database_cross_reference: UWDA:18688

Sertoli Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00011781
PMOID: PMO:00000699
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cells, Sertoli
Synonym: Sertoli Cell
Synonym: Sertoli cell
Synonym: Sertoli cells
Synonym: Structure of sertoli cell
Synonym: Structure of sertoli cell (body structure)
Synonym: Structure of sertoli cell (cell structure)
Synonym: Sustentacular Cell of Testis
Synonym: Sustentacular cell of testis
Synonym: sertoli cell
Tree Number: T2.11.5
Tree Number: T2.12.13
database_cross_reference: CHV:0000011229
database_cross_reference: CSP:2587-5730
database_cross_reference: FMA:72298
database_cross_reference: LCH:U004273
database_cross_reference: LCH_NW:sh85120330
database_cross_reference: MSH:D012708
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12595
database_cross_reference: SNM:T-78110
database_cross_reference: SNMI:T-94110
database_cross_reference: SNOMEDCT_US:40281007
database_cross_reference: UWDA:72298

Enteroendocrine Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00163983
PMOID: PMO:00000700
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: ENDOCRINE CELLS GUT
Synonym: Endocrine Cell, Gastrointestinal
Synonym: Endocrine Cells of Gut
Synonym: Endocrine Cells, Gastrointestinal
Synonym: Enterochromaffin cell
Synonym: Enteroendocrine Cell
Synonym: Enteroendocrine cell
Synonym: Enteroendocrine cell (body structure)
Synonym: Enteroendocrine cell (cell)
Synonym: GEP endocrine cell
Tree Number: T2.11.7
Tree Number: T2.12.21
database_cross_reference: CSP:0605-5566
database_cross_reference: FMA:62930
database_cross_reference: MSH:D019858
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45968
database_cross_reference: SNOMEDCT_US:3789000

Enterochromaffin-like Cells
type: Class
subclass of: Enteroendocrine Cells
MCID: MC00163984
PMOID: PMO:00000701
Subclass_of: Enteroendocrine Cells
Synonym: ECL Cell
Synonym: ECL Cells
Synonym: Enterochromaffin like Cells
Synonym: Enterochromaffin-Like Cell
Synonym: Enterochromaffin-like Cell
Synonym: Enterochromaffin-like cell
Synonym: Enterochromaffin-like cell (body structure)
Synonym: Enterochromaffin-like cell (cell)
Synonym: Gastric argentaffin cell
Synonym: Gastric argentaffin cells
Tree Number: T2.11.7.2
Tree Number: T2.12.21.2
database_cross_reference: CHV:0000038379
database_cross_reference: MSH:D019861
database_cross_reference: NCI:C12576
database_cross_reference: SNM:T-63090
database_cross_reference: SNMI:T-57090
database_cross_reference: SNOMEDCT_US:14099006

Glucagon-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
MCID: MC00009654
PMOID: PMO:00000702
Subclass_of: Enteroendocrine Cells
Synonym: A-cell of pancreatic islet
Synonym: Alpha Cell
Synonym: Alpha cell
Synonym: Alpha cell of pancreas
Synonym: Alpha cell of pancreatic islet
Synonym: Cell, Glucagon-Secreting
Synonym: Cells, Glucagon-Secreting
Synonym: Glucagon Cell
Synonym: Glucagon Secreting Cell
Synonym: Glucagon Secreting Cells
Tree Number: T2.11.7.5
Tree Number: T2.12.21.5
database_cross_reference: CHV:0000009215
database_cross_reference: CSP:2204-1776
database_cross_reference: FMA:70585
database_cross_reference: FMA:84045
database_cross_reference: FMA:85703
database_cross_reference: MSH:D050416
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32052
database_cross_reference: SNM:T-99100
database_cross_reference: SNMI:T-B9100
database_cross_reference: SNOMEDCT_US:61028007
database_cross_reference: UWDA:70585

Insulin-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
MCID: MC00009655
PMOID: PMO:00000703
Subclass_of: Enteroendocrine Cells
Synonym: B Cell, Pancreatic
Synonym: B Cells, Pancreatic
Synonym: B-cell of pancreatic islet
Synonym: Beta Cell
Synonym: Beta cell
Synonym: Beta cell of pancreatic islet
Synonym: Cell, Insulin-Secreting
Synonym: Cells, Insulin-Secreting
Synonym: Insulin Cell
Synonym: Insulin Secreting Cell
Tree Number: T2.11.7.6
Tree Number: T2.12.21.6
database_cross_reference: CHV:0000009216
database_cross_reference: CSP:2204-1776
database_cross_reference: FMA:70586
database_cross_reference: FMA:85704
database_cross_reference: LCH_NW:sh89006279
database_cross_reference: MSH:D050417
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32199
database_cross_reference: SNM:T-99200
database_cross_reference: SNMI:T-B9200
database_cross_reference: SNOMEDCT_US:36565008
database_cross_reference: UWDA:70586

Pancreatic Polypeptide-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
MCID: MC00405557
PMOID: PMO:00000704
Subclass_of: Enteroendocrine Cells
Synonym: Cell, Pancreatic Polypeptide-Secreting
Synonym: Cells, Pancreatic Polypeptide-Secreting
Synonym: PP Cell, Pancreatic
Synonym: PP Cells, Pancreatic
Synonym: PP-cell of pancreatic islet
Synonym: Pancreatic PP Cell
Synonym: Pancreatic PP Cells
Synonym: Pancreatic Polypeptide Cell
Synonym: Pancreatic Polypeptide Cells
Synonym: Pancreatic Polypeptide Secreting Cells
Tree Number: T2.11.7.7
Tree Number: T2.12.21.7
database_cross_reference: FMA:280118
database_cross_reference: FMA:70588
database_cross_reference: MSH:D050418
database_cross_reference: UWDA:70588

Corticotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00578959
PMOID: PMO:00000705
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: ACTH Cell
Synonym: ACTH-Producing Cell, Pituitary
Synonym: ACTH-Producing Cells, Pituitary
Synonym: ACTH-Secreting Cell, Pituitary
Synonym: ACTH-Secreting Cells, Pituitary
Synonym: Adrenocorticotropin-Secreting Cell, Pituitary
Synonym: Adrenocorticotropin-Secreting Cells, Pituitary
Synonym: Cells, Pituitary Adrenocorticotropin-Secreting
Synonym: Corticotrope
Synonym: Corticotrope Cell
Tree Number: T2.11.8
Tree Number: T2.12.30
database_cross_reference: FMA:83098
database_cross_reference: MSH:D052680
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32390
database_cross_reference: SNM:T-91160
database_cross_reference: SNMI:T-B1160
database_cross_reference: SNOMEDCT_US:113332000

Gonadotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00579227
PMOID: PMO:00000706
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Gonadotrope
Synonym: Gonadotrope Cell
Synonym: Gonadotrope cell
Synonym: Gonadotroph
Synonym: Gonadotroph Cell
Synonym: Pituitary delta cell
Synonym: Pituitary delta cell (body structure)
Synonym: Pituitary delta cell (cell)
Synonym: Pituitary gonadotropic cell
Tree Number: T2.11.9
Tree Number: T2.12.31
database_cross_reference: FMA:83100
database_cross_reference: MSH:D052681
database_cross_reference: NCI:C32691
database_cross_reference: SNMI:T-B11A0
database_cross_reference: SNOMEDCT_US:44490009

Lactotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00526773
PMOID: PMO:00000707
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Lactotrope Cell
Synonym: Lactotrope cell
Synonym: Lactotroph
Synonym: Lactotroph Cell
Synonym: Mammotrope
Synonym: Mammotroph
Synonym: PRL Cell
Synonym: Pituitary Prolactin Cell
Synonym: Pituitary Prolactin Cells
Synonym: Pituitary Prolactin Secreting Cells
Tree Number: T2.11.10
Tree Number: T2.12.32
database_cross_reference: CHV:0000042652
database_cross_reference: CSP:2335-0113
database_cross_reference: FMA:83096
database_cross_reference: MSH:D052682
database_cross_reference: NCI:C32911
database_cross_reference: SNM:T-91150
database_cross_reference: SNMI:T-B1150
database_cross_reference: SNOMEDCT_US:65357006

Somatotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00527640
PMOID: PMO:00000708
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: GH Cell
Synonym: GH Cell, Pituitary
Synonym: GH Cells, Pituitary
Synonym: Growth hormone secreting cell
Synonym: Pituitary GH Cell
Synonym: Pituitary GH Cells
Synonym: Pituitary Growth Hormone Secreting Cells
Synonym: Pituitary Growth Hormone-Secreting Cells
Synonym: Somatotrope Cell
Synonym: Somatotrope cell
Tree Number: T2.11.11
Tree Number: T2.12.33
database_cross_reference: FMA:83095
database_cross_reference: MSH:D052683
database_cross_reference: NCI:C33578

Thyrotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00527678
PMOID: PMO:00000709
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cell, TSH
Synonym: Pituitary TSH Producing Cells
Synonym: Pituitary TSH Secreting Cells
Synonym: Pituitary TSH-Producing Cell
Synonym: Pituitary TSH-Producing Cells
Synonym: Pituitary TSH-Secreting Cell
Synonym: Pituitary TSH-Secreting Cells
Synonym: Pituitary thyrotropic cell
Synonym: TSH Cell
Synonym: TSH Cells
Tree Number: T2.11.12
Tree Number: T2.12.34
database_cross_reference: FMA:83099
database_cross_reference: MSH:D052684
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33786

Melanotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
MCID: MC00583107
PMOID: PMO:00000710
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: MSH-Producing Cells, Pituitary
Synonym: Melanotroph
Synonym: Melanotropin-Producing Cell, Pituitary
Synonym: Melanotropin-Producing Cells, Pituitary
Synonym: Pituitary MSH Producing Cells
Synonym: Pituitary MSH-Producing Cell
Synonym: Pituitary MSH-Producing Cells
Synonym: Pituitary Melanotropin Producing Cells
Synonym: Pituitary Melanotropin-Producing Cell
Synonym: Pituitary Melanotropin-Producing Cells
Tree Number: T2.11.13
Tree Number: T2.12.35
database_cross_reference: MSH:D052717

Neuroendocrine Cells
type: Class
subclass of: Endocrine Cells
MCID: MC00527128
PMOID: PMO:00000711
Subclass_of: Endocrine Cells
Synonym: Cell, Neuroendocrine
Synonym: Cells, Neuroendocrine
Synonym: Endocrine Neuron
Synonym: Endocrine Neurons
Synonym: Neuroendocrine Cell
Synonym: Neuroendocrine cell
Synonym: Neuron, Endocrine
Synonym: Neurons, Endocrine
Tree Number: T2.11.14
database_cross_reference: FMA:83810
database_cross_reference: MSH:D055099
database_cross_reference: NCI:C12485

Epithelial Cells
type: Class
subclass of: Cell
MCID: MC00004625
PMOID: PMO:00000712
Subclass_of: Cell
Synonym: Cell, Epithelial
Synonym: Cells, Epithelial
Synonym: Epithelial Cell
Synonym: Epithelial cell
Synonym: Epithelial cell (body structure)
Synonym: Epithelial cell (cell)
Synonym: Epithelial cell, NOS
Synonym: Epithelial cells
Synonym: Epitheliocyte
Synonym: cell epithelial
Tree Number: T2.12
database_cross_reference: AOD:0000016923
database_cross_reference: CHV:0000004577
database_cross_reference: FMA:66768
database_cross_reference: LCH_NW:sh85044464
database_cross_reference: LNC:LA12887-8
database_cross_reference: LNC:LP14043-1
database_cross_reference: LNC:MTHU003158
database_cross_reference: MSH:D004847
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12578
database_cross_reference: PSY:17720
database_cross_reference: RCD:X76yI
database_cross_reference: SNMI:T-00251
database_cross_reference: SNOMEDCT_US:4212006
database_cross_reference: UWDA:66768

Thyroid Epithelial Cells
type: Class
subclass of: Epithelial Cells
MCID: MC00404190
PMOID: PMO:00000713
Subclass_of: Epithelial Cells
Synonym: Cell, Thyroid Epithelial
Synonym: Cell, Thyroid Follicular
Synonym: Cells, Thyroid Epithelial
Synonym: Cells, Thyroid Follicular
Synonym: Epithelial Cell, Thyroid
Synonym: Epithelial Cells, Thyroid
Synonym: Follicular Cell, Thyroid
Synonym: Follicular Cells, Thyroid
Synonym: Follicular cell of thyroid gland
Synonym: Principal cell of thyroid gland
Tree Number: T2.12.2
database_cross_reference: CHV:0000055928
database_cross_reference: FMA:68782
database_cross_reference: MSH:D000072637
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33783
database_cross_reference: NCI_NCI-GLOSS:CDR0000044543
database_cross_reference: UWDA:68782

Ameloblasts
type: Class
subclass of: Epithelial Cells
MCID: MC00000708
PMOID: PMO:00000714
Subclass_of: Epithelial Cells
Synonym: Ameloblast
Synonym: ameloblast
Tree Number: T2.12.3
database_cross_reference: CHV:0000000987
database_cross_reference: CSP:0835-5453
database_cross_reference: FMA:70576
database_cross_reference: MSH:D000565
database_cross_reference: NCI:C12579
database_cross_reference: UWDA:70576

Chromatophores
type: Class
subclass of: Epithelial Cells
MCID: MC00002807
PMOID: PMO:00000715
Subclass_of: Epithelial Cells
Synonym: Chromatophore
Synonym: chromatophore
Tree Number: T2.12.4
database_cross_reference: CSP:2328-1137
database_cross_reference: LCH:U001008
database_cross_reference: LCH_NW:sh85025337
database_cross_reference: MSH:D002856
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12581

Melanophores
type: Class
subclass of: Chromatophores
MCID: MC00007995
PMOID: PMO:00000716
Subclass_of: Chromatophores
Synonym: Melanophore
Tree Number: T2.12.4.1
database_cross_reference: LCH:U002890
database_cross_reference: LCH_NW:sh85083385
database_cross_reference: MSH:D008547
database_cross_reference: NCI:C12582

Labyrinth Supporting Cells
type: Class
subclass of: Epithelial Cells
MCID: MC00007313
PMOID: PMO:00000717
Subclass_of: Epithelial Cells
Synonym: Cell of Cladius
Synonym: Cell, Labyrinth Supporting
Synonym: Cells, Labyrinth Supporting
Synonym: External supporting cell of organ of Corti
Synonym: Labyrinth Supporting Cell
Synonym: Outer Phalangeal Cell
Synonym: Outer Supporting Cell
Synonym: Outer supporting cell
Synonym: Structure of supporting cell of organ of Corti
Synonym: Structure of supporting cell of organ of Corti (body structure)
Tree Number: T2.12.8
database_cross_reference: FMA:79802
database_cross_reference: MSH:D007760
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12590
database_cross_reference: NCI:C33240
database_cross_reference: SNM:T-XY783
database_cross_reference: SNMI:T-AB783
database_cross_reference: SNOMEDCT_US:28199004

Melanocytes
type: Class
subclass of: Epithelial Cells
MCID: MC00007992
PMOID: PMO:00000718
Subclass_of: Epithelial Cells
Synonym: Melanocyte
Synonym: Melanocyte (cell)
Synonym: melanocyte
Synonym: melanocytes
Tree Number: T2.12.11
database_cross_reference: AOD:0000017122
database_cross_reference: CHV:0000007893
database_cross_reference: CSP:2328-1309
database_cross_reference: FMA:70545
database_cross_reference: LCH:U002888
database_cross_reference: LCH_NW:sh85083380
database_cross_reference: MSH:D008544
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12591
database_cross_reference: NCI_NCI-GLOSS:CDR0000046292
database_cross_reference: SNM:T-01151
database_cross_reference: SNMI:T-01151
database_cross_reference: SNOMEDCT_US:9683001

Keratinocytes
type: Class
subclass of: Epithelial Cells
MCID: MC00007193
PMOID: PMO:00000719
Subclass_of: Epithelial Cells
Synonym: KERATINOCYTE
Synonym: Keratinized cell of epidermis
Synonym: Keratinocyte
Synonym: Keratinocyte (cell)
Synonym: Keratinocytes [Chemical/Ingredient]
Synonym: keratinocyte
Synonym: keratinocytes
Tree Number: T2.12.15
database_cross_reference: CHV:0000007051
database_cross_reference: CSP:2716-1254
database_cross_reference: FMA:62879
database_cross_reference: LCH_NW:sh85072034
database_cross_reference: MSH:D015603
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12589
database_cross_reference: NCI_CDISC:C12589
database_cross_reference: NDFRT:N0000184312
database_cross_reference: SNM:T-01152
database_cross_reference: SNMI:T-01152
database_cross_reference: SNOMEDCT_US:74447004
database_cross_reference: UWDA:62879

Merkel Cells
type: Class
subclass of: Epithelial Cells
MCID: MC00067163
PMOID: PMO:00000720
Subclass_of: Epithelial Cells
Synonym: Cells, Merkel
Synonym: MERKEL RECEPT
Synonym: MERKELS RECEPT
Synonym: Merkel Cell
Synonym: Merkel Receptor
Synonym: Merkel Receptors
Synonym: Merkel cell
Synonym: Merkel cells
Synonym: Merkel's Receptor
Synonym: Merkel's Receptors
Tree Number: T2.12.18
database_cross_reference: CHV:0000020727
database_cross_reference: FMA:70548
database_cross_reference: LCH_NW:sh00000072
database_cross_reference: MSH:D018862
database_cross_reference: NCI:C12592
database_cross_reference: NCI_NCI-GLOSS:CDR0000674683
database_cross_reference: SNM:T-01154
database_cross_reference: SNMI:T-01154
database_cross_reference: SNOMEDCT_US:10149001
database_cross_reference: UWDA:70548

Hepatocytes
type: Class
subclass of: Epithelial Cells
MCID: MC00075315
PMOID: PMO:00000721
Subclass_of: Epithelial Cells
Synonym: Cell, Hepatic
Synonym: Cells, Hepatic
Synonym: Hepatic Cell
Synonym: Hepatic Cells
Synonym: Hepatic Parenchymal Cell
Synonym: Hepatic parenchymal cell
Synonym: Hepatic parenchymal cell (body structure)
Synonym: Hepatic parenchymal cell (cell)
Synonym: Hepatocyte
Synonym: Hepatocytus
Tree Number: T2.12.26
database_cross_reference: AOD:0000017315
database_cross_reference: AOD:0000017316
database_cross_reference: CHV:0000022135
database_cross_reference: CSP:1754-0682
database_cross_reference: FMA:14515
database_cross_reference: FMA:63179
database_cross_reference: LCH_NW:sh85077772
database_cross_reference: LNC:LP68387-7
database_cross_reference: MSH:D022781
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12588
database_cross_reference: NCI_NCI-GLOSS:CDR0000046364
database_cross_reference: SNM:T-56260
database_cross_reference: SNMI:T-62260
database_cross_reference: SNOMEDCT_US:30396005
database_cross_reference: UWDA:14515
database_cross_reference: UWDA:63179

Endothelial Cells
type: Class
subclass of: Epithelial Cells
MCID: MC00073650
PMOID: PMO:00000722
Subclass_of: Epithelial Cells
Synonym: Cell, Endothelial
Synonym: Cells, Endothelial
Synonym: Endothelial Cell
Synonym: Endothelial cell
Synonym: Endothelial cell (body structure)
Synonym: Endothelial cell (cell)
Synonym: Endothelial cells
Synonym: Endotheliocyte
Synonym: cell endothelial
Synonym: cells endothelial
Tree Number: T2.12.27
database_cross_reference: AOD:0000016937
database_cross_reference: CHV:0000021886
database_cross_reference: FMA:66772
database_cross_reference: LCH_NW:sh2012001927
database_cross_reference: LNC:LP99346-6
database_cross_reference: MSH:D042783
database_cross_reference: NCI:C12865
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044203
database_cross_reference: SNM:T-05130
database_cross_reference: SNMI:T-1A131
database_cross_reference: SNOMEDCT_US:45709008
database_cross_reference: UWDA:66772

Hemangioblasts
type: Class
subclass of: Hematopoietic Stem Cells
subclass of: Endothelial Cells
MCID: MC00715362
PMOID: PMO:00000723
Subclass_of: Endothelial Cells
Subclass_of: Hematopoietic Stem Cells
Synonym: Hemangioblast
Tree Number: T2.12.27.2
Tree Number: T2.34.2.4
database_cross_reference: MSH:D055018

Human Umbilical Vein Endothelial Cells
type: Class
subclass of: Endothelial Cells
MCID: MC00831141
PMOID: PMO:00000724
Subclass_of: Endothelial Cells
Synonym: Cell, HUVEC
Synonym: Cells, HUVEC
Synonym: Endothelial Cells, Human Umbilical Vein
Synonym: HUVEC Cell
Synonym: HUVEC Cells
Tree Number: T2.12.27.3
database_cross_reference: MSH:D061307

Neuroepithelial Cells
type: Class
subclass of: Epithelial Cells
MCID: MC00516287
PMOID: PMO:00000725
Subclass_of: Epithelial Cells
Synonym: Cell, Neuroepithelial
Synonym: Cells, Neuroepithelial
Synonym: Neuroepithelial Cell
Tree Number: T2.12.28
database_cross_reference: MSH:D046569
database_cross_reference: NCI:C41410

Neuroepithelial Bodies
type: Class
subclass of: Neuroepithelial Cells
MCID: MC00516286
PMOID: PMO:00000726
Subclass_of: Neuroepithelial Cells
Synonym: Bodies, Neuroepithelial
Synonym: Body, Neuroepithelial
Synonym: Neuroepithelial Body
Tree Number: T2.12.28.1
database_cross_reference: MSH:D046568

Podocytes
type: Class
subclass of: Epithelial Cells
MCID: MC00452988
PMOID: PMO:00000727
Subclass_of: Epithelial Cells
Synonym: Epithelial Cells, Glomerular Visceral
Synonym: Glomerular Visceral Epithelial Cells
Synonym: Podocyte
Synonym: Visceral Epithelial Cell
Synonym: Visceral Epithelial Cells, Glomerular
Synonym: glomerular visceral epithelial cell
Synonym: podocyte
Synonym: visceral glomerular epithelial cell
Tree Number: T2.12.29
database_cross_reference: CSP:5004-0066
database_cross_reference: MSH:D050199
database_cross_reference: NCI:C33334

Alveolar Epithelial Cells
type: Class
subclass of: Epithelial Cells
MCID: MC00073893
PMOID: PMO:00000728
Subclass_of: Epithelial Cells
Synonym: Alveolar Cell
Synonym: Alveolar Cells
Synonym: Alveolar Epithelial Cell
Synonym: Alveolar cell
Synonym: Alveolar epithelial cell
Synonym: Cell, Alveolar
Synonym: Cell, Alveolar Epithelial
Synonym: Cells, Alveolar
Synonym: Cells, Alveolar Epithelial
Synonym: Epithelial Cell, Alveolar
Tree Number: T2.12.36
database_cross_reference: CHV:0000021934
database_cross_reference: CSP:2612-4512
database_cross_reference: FMA:62499
database_cross_reference: MSH:D056809
database_cross_reference: NCI:C32053
database_cross_reference: SNM:T-28050
database_cross_reference: SNMI:T-28050
database_cross_reference: SNOMEDCT_US:47438009
database_cross_reference: UWDA:62499

Atypical Squamous Cells of the Cervix
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000729
Subclass_of: Epithelial Cells
Tree Number: T2.12.39

Erythroid Cells
type: Class
subclass of: Cell
MCID: MC00421503
PMOID: PMO:00000730
Subclass_of: Cell
Synonym: Cell, Erythroid
Synonym: Cells, Erythroid
Synonym: Erythroid Cell
Synonym: Erythroid cell
Synonym: Erythroid cell (cell)
Synonym: Erythroid cells
Synonym: Erythropoietic cell
Synonym: erythroid cell
Synonym: erythroid cells
Tree Number: T2.13
database_cross_reference: CHV:0000056249
database_cross_reference: FMA:83516
database_cross_reference: LNC:LP32048-8
database_cross_reference: LNC:LP35614-4
database_cross_reference: LNC:MTHU030086
database_cross_reference: MSH:D041905
database_cross_reference: SNOMEDCT_US:414128005

Eukaryotic Cells
type: Class
subclass of: Cell
PMOID: PMO:00000731
Subclass_of: Cell
Tree Number: T2.14

Germ Cells
type: Class
subclass of: Cell
MCID: MC00005579
PMOID: PMO:00000732
Subclass_of: Cell
Synonym: Cell, Germ
Synonym: Cell, Germ-Line
Synonym: Cells, Germ
Synonym: Cells, Germ-Line
Synonym: Gamete
Synonym: Gametes
Synonym: Germ Cell
Synonym: Germ Line Cells
Synonym: Germ cell
Synonym: Germ cells
Tree Number: T2.15
database_cross_reference: AOD:0000021975
database_cross_reference: AOD:0000021976
database_cross_reference: CHV:0000005470
database_cross_reference: CSP:1138-4561
database_cross_reference: FMA:18649
database_cross_reference: LCH:U001951
database_cross_reference: LCH_NW:sh85054322
database_cross_reference: MSH:D005854
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12597
database_cross_reference: NCI_NCI-GLOSS:CDR0000046382
database_cross_reference: NCI_NCI-GLOSS:CDR0000046563
database_cross_reference: UWDA:18649

Embryonic Germ Cells
type: Class
subclass of: Germ Cells
subclass of: Embryonic Stem Cells
MCID: MC01007830
PMOID: PMO:00000733
Subclass_of: Embryonic Stem Cells
Subclass_of: Germ Cells
Synonym: Cell, EG
Synonym: Cell, Embryonic Germ
Synonym: Cells, EG
Synonym: Cells, Embryonic Germ
Synonym: EG Cell
Synonym: EG Cells
Synonym: Embryonic Germ Cell
Synonym: Germ Cell, Embryonic
Synonym: Germ Cells, Embryonic
Tree Number: T2.15.1
Tree Number: T2.34.7.1.3
database_cross_reference: MSH:D000066473

Oocytes
type: Class
subclass of: Ovum
MCID: MC00009178
PMOID: PMO:00000734
Subclass_of: Ovum
Synonym: Oocyte
Synonym: Oocyte (cell)
Synonym: Oocyte, NOS
Synonym: Ovocyte
Synonym: Ovocyte, NOS
Synonym: Ovocytes
Synonym: cells oocytes
Synonym: oocyte
Synonym: oocyte (cell)
Synonym: oocytes
Tree Number: T2.15.2.1
database_cross_reference: AOD:0000002597
database_cross_reference: AOD:0000021972
database_cross_reference: CHV:0000008953
database_cross_reference: CSP:1138-3157
database_cross_reference: FMA:18644
database_cross_reference: MSH:D009865
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12598
database_cross_reference: SNMI:T-87509
database_cross_reference: SNOMEDCT_US:86082002
database_cross_reference: UWDA:18644

Polar Bodies
type: Class
subclass of: Oocytes
MCID: MC00704876
PMOID: PMO:00000735
Subclass_of: Oocytes
Synonym: Bodies, Polar
Synonym: Body, Polar
Synonym: Cell, Polar
Synonym: Cells, Polar
Synonym: Polar Body
Synonym: Polar Cell
Synonym: Polar Cells
Synonym: Polar body
Tree Number: T2.15.2.1.1
database_cross_reference: FMA:85543
database_cross_reference: MSH:D059705

Oogonia
type: Class
subclass of: Ovum
MCID: MC00009180
PMOID: PMO:00000736
Subclass_of: Ovum
Synonym: Oogonium
Synonym: Ovocytus primarium
Synonym: Primary Oocyte
Synonym: Primary oocyte
Synonym: Primordial Ovum
Synonym: Primordial ovum
Synonym: Primordial ovum (cell)
Synonym: oogonium (cell)
Tree Number: T2.15.2.2
database_cross_reference: AOD:0000002595
database_cross_reference: FMA:18645
database_cross_reference: FMA:83673
database_cross_reference: MSH:D009867
database_cross_reference: NCI:C12600
database_cross_reference: SNM:T-87510
database_cross_reference: SNMI:T-87510
database_cross_reference: SNOMEDCT_US:78829006
database_cross_reference: UWDA:18645

Spermatozoa
type: Class
subclass of: Germ Cells
MCID: MC00012107
PMOID: PMO:00000737
Subclass_of: Germ Cells
Synonym: Androcyte
Synonym: Mature sperm cell
Synonym: SPERMATOZOON
Synonym: Sperm
Synonym: Sperm Cell
Synonym: Sperm cell
Synonym: Spermatic
Synonym: Spermatozoa (cell)
Synonym: Spermatozoon
Synonym: Spermium
Tree Number: T2.15.3
database_cross_reference: AOD:0000001999
database_cross_reference: AOD:0000021999
database_cross_reference: AOD:0000022001
database_cross_reference: AOD:0000022002
database_cross_reference: AOD:0000022004
database_cross_reference: AOD:0000022005
database_cross_reference: CHV:0000011591
database_cross_reference: CSP:1138-6433
database_cross_reference: FMA:67338
database_cross_reference: FMA:72290
database_cross_reference: LCH:U004418
database_cross_reference: LCH_NW:sh85126546
database_cross_reference: LNC:LA12898-5
database_cross_reference: LNC:LP14765-9
database_cross_reference: LNC:LP7599-6
database_cross_reference: LNC:MTHU001966
database_cross_reference: LNC:MTHU042523
database_cross_reference: MSH:D013094
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12602
database_cross_reference: NCI_CDISC:C12602
database_cross_reference: NCI_NCI-GLOSS:CDR0000257221
database_cross_reference: PSY:49230
database_cross_reference: SNM:T-78180
database_cross_reference: SNMI:T-94180
database_cross_reference: SNOMEDCT_US:6789008
database_cross_reference: UWDA:67338
database_cross_reference: UWDA:72290

Sperm Head
type: Class
subclass of: Spermatozoa
MCID: MC00012087
PMOID: PMO:00000738
Subclass_of: Spermatozoa
Synonym: Caput (Spermatozoon)
Synonym: Caput of sperm
Synonym: Caput of spermatozoon
Synonym: Head of sperm
Synonym: Head of spermatozoon
Synonym: Head of the Spermatozoon
Synonym: Head, Sperm
Synonym: Heads, Sperm
Synonym: Sperm Heads
Synonym: Spermatozoa.head
Tree Number: T2.15.3.1
database_cross_reference: FMA:67376
database_cross_reference: LNC:LP34798-6
database_cross_reference: MSH:D013077
database_cross_reference: NCI:C12603
database_cross_reference: UWDA:67376

Spermatids
type: Class
subclass of: Spermatozoa
MCID: MC00012099
PMOID: PMO:00000739
Subclass_of: Spermatozoa
Synonym: Nematoblast
Synonym: Spermatid
Synonym: Spermatid (cell)
Synonym: Spermatoblast
Synonym: Spermatoblasts
Synonym: Spermoblast
Synonym: nematoblast
Synonym: spermatid
Synonym: spermatoblast
Synonym: spermid
Tree Number: T2.15.3.3
database_cross_reference: AOD:0000002606
database_cross_reference: AOD:0000021996
database_cross_reference: AOD:0000021997
database_cross_reference: AOD:0000021998
database_cross_reference: AOD:0000022000
database_cross_reference: FMA:72294
database_cross_reference: LNC:LP34676-4
database_cross_reference: LNC:MTHU024958
database_cross_reference: MSH:D013087
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12604
database_cross_reference: SNM:T-78170
database_cross_reference: SNMI:T-94170
database_cross_reference: SNOMEDCT_US:38326003
database_cross_reference: UWDA:72294

Spermatocytes
type: Class
subclass of: Spermatozoa
MCID: MC00012103
PMOID: PMO:00000740
Subclass_of: Spermatozoa
Synonym: Spermatocyte
Synonym: Spermiocyte
Synonym: Spermiocytes
Synonym: spermatocyte
Tree Number: T2.15.3.4
database_cross_reference: AOD:0000002607
database_cross_reference: FMA:84049
database_cross_reference: LNC:LP32764-0
database_cross_reference: MSH:D013090
database_cross_reference: NCI:C12605

Spermatogonia
type: Class
subclass of: Spermatozoa
MCID: MC00012106
PMOID: PMO:00000741
Subclass_of: Spermatozoa
Synonym: Primitive sperm cell
Synonym: Spermatogonia (cell)
Synonym: Spermatogonias
Synonym: Spermatogonium
Synonym: Spermatophore
Synonym: Spermatophores
Synonym: cells spermatogonia
Synonym: spermatogone
Synonym: spermatogonia
Synonym: spermatogonium
Tree Number: T2.15.3.5
database_cross_reference: AOD:0000002605
database_cross_reference: AOD:0000021992
database_cross_reference: AOD:0000021993
database_cross_reference: AOD:0000021994
database_cross_reference: AOD:0000021995
database_cross_reference: CHV:0000011590
database_cross_reference: FMA:72291
database_cross_reference: LCH_NW:sh85126544
database_cross_reference: LNC:LP14757-6
database_cross_reference: LNC:MTHU001958
database_cross_reference: MSH:D013093
database_cross_reference: NCI:C12606
database_cross_reference: SNM:T-78140
database_cross_reference: SNMI:T-94140
database_cross_reference: SNOMEDCT_US:67807008
database_cross_reference: UWDA:72291

Sperm Midpiece
type: Class
subclass of: Spermatozoa
MCID: MC00377767
PMOID: PMO:00000742
Subclass_of: Spermatozoa
Synonym: Midpiece, Sperm
Synonym: Midpieces, Sperm
Synonym: Sperm Midpieces
Synonym: Spermatozoa.midpiece
Synonym: sperm midpiece
Tree Number: T2.15.3.6
database_cross_reference: GO:GO:0097225
database_cross_reference: LNC:LP34799-4
database_cross_reference: MSH:D032961

Germ Cells, Plant
type: Class
subclass of: Germ Cells
PMOID: PMO:00000743
Subclass_of: Germ Cells
Tree Number: T2.15.4

Giant Cells
type: Class
subclass of: Cell
MCID: MC00005594
PMOID: PMO:00000744
Subclass_of: Cell
Synonym: Abnormal numbers of nuclei
Synonym: Cell, Giant
Synonym: Cell, Multinucleated Giant
Synonym: Cells, Giant
Synonym: Cells, Multinucleated Giant
Synonym: Giant Cell
Synonym: Giant Cell, Multinucleated
Synonym: Giant Cells, Multinucleated
Synonym: Giant cell
Synonym: Giant cell, NOS
Tree Number: T2.16
database_cross_reference: CHV:0000005484
database_cross_reference: FMA:83623
database_cross_reference: MSH:D015726
database_cross_reference: NCI:C12607
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12607
database_cross_reference: NCI_NCI-GLOSS:CDR0000044625
database_cross_reference: SNM:M-69210
database_cross_reference: SNM:M-69430
database_cross_reference: SNM:T-06550
database_cross_reference: SNMI:M-62500
database_cross_reference: SNMI:T-C1550
database_cross_reference: SNOMEDCT_US:60401004
database_cross_reference: SNOMEDCT_US:81480003
database_cross_reference: SNOMEDCT_VET:45441000009108

Hepatic Stellate Cells
type: Class
subclass of: Cell
MCID: MC00710508
PMOID: PMO:00000745
Subclass_of: Cell
Synonym: Cell, Hepatic Stellate
Synonym: Cells, Hepatic Stellate
Synonym: Hepatic Stellate Cell
Synonym: Stellate Cell, Hepatic
Synonym: Stellate Cells, Hepatic
Synonym: cell hepatic stellate
Synonym: cells hepatic stellate
Synonym: hepatic stellate cell
Tree Number: T2.17
database_cross_reference: AOD:0000017325
database_cross_reference: CHV:0000049344
database_cross_reference: MSH:D055166
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32734

Mesophyll Cells
type: Class
subclass of: Cell
MCID: MC00797892
PMOID: PMO:00000746
Subclass_of: Cell
Synonym: Cell, Mesophyll
Synonym: Cells, Mesophyll
Synonym: Mesophyll Cell
Tree Number: T2.18
database_cross_reference: MSH:D058503

Muscle Cells
type: Class
subclass of: Cell
MCID: MC00182852
PMOID: PMO:00000747
Subclass_of: Cell
Synonym: Mature Muscle Cell
Synonym: Mature Muscle Cells
Synonym: Muscle Cell
Synonym: Muscle Cell, Mature
Synonym: Muscle Cells, Mature
Synonym: Muscle cell
Synonym: Muscle cells
Synonym: Myocyte
Synonym: Myocytes
Synonym: cell muscle
Tree Number: T2.19
database_cross_reference: AOD:0000016896
database_cross_reference: AOD:0000027638
database_cross_reference: CHV:0000041649
database_cross_reference: CSP:1975-6404
database_cross_reference: FMA:67328
database_cross_reference: LCH_NW:sh85088676
database_cross_reference: MSH:D032342
database_cross_reference: NCI:C12612
database_cross_reference: UWDA:67328

Myocytes, Smooth Muscle
type: Class
subclass of: Muscle Cells
MCID: MC00377760
PMOID: PMO:00000748
Subclass_of: Muscle Cells
Synonym: Cell, Smooth Muscle
Synonym: Cells, Smooth Muscle
Synonym: Leiomyocyte
Synonym: Myocyte of smooth muscle
Synonym: Myocyte, Smooth Muscle
Synonym: Myocytus nonstriatus
Synonym: Non-striated muscle fiber
Synonym: Smooth Muscle Cell
Synonym: Smooth Muscle Cells
Synonym: Smooth Muscle Myocyte
Tree Number: T2.19.3
database_cross_reference: CHV:0000054912
database_cross_reference: FMA:14072
database_cross_reference: GO:GO:0030485
database_cross_reference: MSH:D032389
database_cross_reference: NCI:C13001
database_cross_reference: UWDA:14072

Interstitial Cells of Cajal
type: Class
subclass of: Muscle Cells
MCID: MC00524176
PMOID: PMO:00000749
Subclass_of: Muscle Cells
Synonym: Cajal Interstitial Cells
Synonym: ICC (Interstitial cell of Cajal)
Synonym: Interstitial Cell of Cajal
Synonym: Interstitial cell of Cajal
Synonym: gastrointestinal pacemaker cell
Synonym: interstitial cell of Cajal
Tree Number: T2.19.4
database_cross_reference: CSP:5006-0020
database_cross_reference: FMA:86573
database_cross_reference: MSH:D056885
database_cross_reference: NCI:C32871

Myeloid Cells
type: Class
subclass of: Cell
MCID: MC00310018
PMOID: PMO:00000750
Subclass_of: Cell
Synonym: Cell, Myeloid
Synonym: Cells, Myeloid
Synonym: Myeloid Cell
Synonym: Myeloid cells
Synonym: myeloid cell
Synonym: myeloid cells
Tree Number: T2.20
database_cross_reference: CHV:0000052271
database_cross_reference: LNC:LP15094-3
database_cross_reference: MSH:D022423
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12549

Myeloid-Derived Suppressor Cells
type: Class
subclass of: Myeloid Cells
MCID: MC01054785
PMOID: PMO:00000751
Subclass_of: Myeloid Cells
Synonym: Cell, Myeloid-Derived Suppressor
Synonym: Cells, Myeloid-Derived Suppressor
Synonym: MDSCs
Synonym: Myeloid Derived Suppressor Cells
Synonym: Myeloid-Derived Suppressor Cell
Synonym: Suppressor Cell, Myeloid-Derived
Synonym: Suppressor Cells, Myeloid-Derived
Tree Number: T2.20.1
database_cross_reference: MSH:D000072737

Neoplastic Cells, Circulating
type: Class
subclass of: Cell
MCID: MC00008716
PMOID: PMO:00000752
Subclass_of: Cell
Synonym: CELLS NEOPL CIRC
Synonym: CIRC CELLS NEOPL
Synonym: CIRCULATING TUMOR CELL
Synonym: CTC
Synonym: Cell, Circulating Neoplastic
Synonym: Cell, Circulating Tumor
Synonym: Cell, Neoplasm Circulating
Synonym: Cells, Circulating Neoplastic
Synonym: Cells, Circulating Tumor
Synonym: Cells, Neoplasm Circulating
Tree Number: T2.21
database_cross_reference: CSP:2027-2462
database_cross_reference: LNC:LP133414-5
database_cross_reference: LNC:LP135291-5
database_cross_reference: MSH:D009360
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C63797
database_cross_reference: NCI_CDISC:C63797
database_cross_reference: NDFRT:N0000002122

Neuroglia
type: Class
subclass of: Cell
MCID: MC00008824
PMOID: PMO:00000753
Subclass_of: Cell
Synonym: A04 GLIA
Synonym: Cell, Glial
Synonym: Cell, Neuroglial
Synonym: Cells, Glial
Synonym: Cells, Neuroglial
Synonym: GLIA
Synonym: Glia
Synonym: Glia (body structure)
Synonym: Glial
Synonym: Glial Cell
Tree Number: T2.22
database_cross_reference: AOD:0000017751
database_cross_reference: AOD:0000028027
database_cross_reference: AOD:0000028029
database_cross_reference: AOD:0000028030
database_cross_reference: CHV:0000008637
database_cross_reference: CHV:0000037943
database_cross_reference: CSP:2047-3472
database_cross_reference: FMA:54536
database_cross_reference: FMA:54541
database_cross_reference: LCH:U003190
database_cross_reference: LCH_NW:sh85091124
database_cross_reference: MSH:D009457
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12615
database_cross_reference: NCI_NCI-GLOSS:CDR0000269440
database_cross_reference: NCI_NCI-GLOSS:CDR0000572232
database_cross_reference: SNM:T-X0400
database_cross_reference: SNM:U000495
database_cross_reference: SNMI:T-A0400
database_cross_reference: SNMI:T-A0405
database_cross_reference: SNOMEDCT_US:2156000
database_cross_reference: SNOMEDCT_US:58861006
database_cross_reference: UWDA:54541

Oligodendrocyte Precursor Cells
type: Class
subclass of: Neuroglia
subclass of: Neural Stem Cells
PMOID: PMO:00000754
Subclass_of: Neural Stem Cells
Subclass_of: Neuroglia
Tree Number: T2.22.1
Tree Number: T2.34.10.1

Astrocytes
type: Class
subclass of: Neuroglia
MCID: MC00001334
PMOID: PMO:00000755
Subclass_of: Neuroglia
Synonym: Astrocyte
Synonym: Astrocyte (cell)
Synonym: Astrocyte, NOS
Synonym: Astrocytus
Synonym: Astroglia
Synonym: Astroglias
Synonym: astrocyte
Synonym: astrocyte cells
Synonym: astrocytes
Synonym: astroglia
Tree Number: T2.22.2
database_cross_reference: AOD:0000017757
database_cross_reference: CHV:0000001545
database_cross_reference: CSP:2047-3484
database_cross_reference: FMA:54537
database_cross_reference: LCH:U000408
database_cross_reference: LCH_NW:sh85008884
database_cross_reference: MSH:D001253
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12477
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000269436
database_cross_reference: OMIM:MTHU031932
database_cross_reference: SNM:T-X0420
database_cross_reference: SNMI:T-A0420
database_cross_reference: SNOMEDCT_US:78399007

Oligodendroglia
type: Class
subclass of: Neuroglia
MCID: MC00009141
PMOID: PMO:00000756
Subclass_of: Neuroglia
Synonym: Oligodendrocyte
Synonym: Oligodendrocyte (cell)
Synonym: Oligodendrocytes
Synonym: Oligodendrocytus
Synonym: Oligodendroglia Cell
Synonym: Oligodendroglia cell
Synonym: Oligodendroglial cell
Synonym: cells oligodendrocytes
Synonym: oligodendrocyte
Synonym: oligodendrocytes
Tree Number: T2.22.3
database_cross_reference: AOD:0000017761
database_cross_reference: AOD:0000028032
database_cross_reference: CHV:0000008929
database_cross_reference: CSP:2047-3506
database_cross_reference: FMA:54540
database_cross_reference: FMA:83665
database_cross_reference: LCH:U003336
database_cross_reference: LCH_NW:sh85094602
database_cross_reference: MSH:D009836
database_cross_reference: NCI:C12618
database_cross_reference: NCI_NCI-GLOSS:CDR0000540447
database_cross_reference: SNM:T-X0450
database_cross_reference: SNMI:T-A0450
database_cross_reference: SNOMEDCT_US:66254009

Schwann Cells
type: Class
subclass of: Neuroglia
MCID: MC00011653
PMOID: PMO:00000757
Subclass_of: Neuroglia
Synonym: Cells, Schwann
Synonym: Neurilemma Cell
Synonym: Neurilemma cell
Synonym: Neurilemma cell (body structure)
Synonym: Neurilemma cell (cell)
Synonym: Neurilemmal Cell
Synonym: Neurilemmal cell
Synonym: Peripheral glial cell
Synonym: Peripheral neuroglial cell
Synonym: Schwann Cell
Tree Number: T2.22.4
database_cross_reference: AOD:0000017753
database_cross_reference: CHV:0000011105
database_cross_reference: CSP:2049-8500
database_cross_reference: FMA:62121
database_cross_reference: MSH:D012583
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12620
database_cross_reference: NCI_NCI-GLOSS:CDR0000269452
database_cross_reference: SNM:T-X0520
database_cross_reference: SNMI:T-A0520
database_cross_reference: SNOMEDCT_US:44591005

Microglia
type: Class
subclass of: Neuroglia
MCID: MC00067298
PMOID: PMO:00000758
Subclass_of: Neuroglia
Synonym: Gitter cell
Synonym: Hortega cell
Synonym: Microglial Cell
Synonym: Microglial cell
Synonym: Microglial cells set
Synonym: Microgliocyte
Synonym: Microgliocyte (cell)
Synonym: Set of microglial cells
Synonym: Small glial cell
Synonym: gitter cell
Tree Number: T2.22.5
database_cross_reference: AOD:0000017762
database_cross_reference: AOD:0000028033
database_cross_reference: AOD:0000028037
database_cross_reference: AOD:0000028039
database_cross_reference: AOD:0000028041
database_cross_reference: CHV:0000020811
database_cross_reference: CSP:2047-3495
database_cross_reference: FMA:54539
database_cross_reference: FMA:68923
database_cross_reference: LCH_NW:sh85084845
database_cross_reference: MSH:D017628
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12616
database_cross_reference: SNM:M-69510
database_cross_reference: SNM:T-X0460
database_cross_reference: SNMI:T-A0460
database_cross_reference: SNOMEDCT_US:63483002
database_cross_reference: UWDA:68923

Neuropil
type: Class
subclass of: Neuroglia
subclass of: Neurons
MCID: MC00075698
PMOID: PMO:00000759
Subclass_of: Neuroglia
Subclass_of: Neurons
Synonym: Neuropil (body structure)
Synonym: Neuropile
Synonym: Neuropiles
Synonym: Neuropils
Synonym: neuropil
Synonym: neuropiles
Tree Number: T2.22.6
Tree Number: T2.23.16
database_cross_reference: CHV:0000022225
database_cross_reference: CSP:2047-3725
database_cross_reference: FMA:261269
database_cross_reference: MSH:D019581
database_cross_reference: NCI:C12617
database_cross_reference: SNM:T-X0310
database_cross_reference: SNMI:T-A0310
database_cross_reference: SNOMEDCT_US:67146008

Satellite Cells, Perineuronal
type: Class
subclass of: Neuroglia
MCID: MC00067187
PMOID: PMO:00000760
Subclass_of: Neuroglia
Synonym: Cell, Perineuronal Satellite
Synonym: Cells, Perineuronal Satellite
Synonym: Perineuronal Satellite Cell
Synonym: Perineuronal Satellite Cells
Synonym: Perineuronal satellite cell
Synonym: Perineuronal satellite cell (body structure)
Synonym: Perineuronal satellite cell (cell)
Synonym: Satellite Cell
Synonym: Satellite Cell, Perineuronal
Synonym: cell satellite
Tree Number: T2.22.7
database_cross_reference: CHV:0000020737
database_cross_reference: CSP:2047-3601
database_cross_reference: MSH:D027161
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12619
database_cross_reference: NCI:C33516
database_cross_reference: SNM:T-X0480
database_cross_reference: SNMI:T-A0480
database_cross_reference: SNOMEDCT_US:28922004

Ependymoglial Cells
type: Class
subclass of: Neuroglia
MCID: MC00926826
PMOID: PMO:00000761
Subclass_of: Neuroglia
Synonym: Cell, Ependymoglial
Synonym: Cells, Ependymoglial
Synonym: Ependymoglial Cell
Tree Number: T2.22.8
database_cross_reference: MSH:D063928
database_cross_reference: MTH:NOCODE

Neurons
type: Class
subclass of: Cell
MCID: MC00008842
PMOID: PMO:00000762
Subclass_of: Cell
Synonym: Cell, Nerve
Synonym: Cells, Nerve
Synonym: Nerve Cell
Synonym: Nerve Cells
Synonym: Nerve cell
Synonym: Neural Cell
Synonym: Neural cell
Synonym: Neurocyte
Synonym: Neuron
Synonym: Neuron (cell)
Tree Number: T2.23
database_cross_reference: AOD:0000017676
database_cross_reference: AOD:0000017677
database_cross_reference: AOD:0000027982
database_cross_reference: AOD:0000027983
database_cross_reference: AOD:0000027985
database_cross_reference: AOD:0000027986
database_cross_reference: AOD:0000027987
database_cross_reference: CHV:0000008658
database_cross_reference: CHV:0000043938
database_cross_reference: CSP:2047-3601
database_cross_reference: FMA:54527
database_cross_reference: FMA:70333
database_cross_reference: LCH:U003198
database_cross_reference: LCH_NW:sh85091153
database_cross_reference: MSH:D009474
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12623
database_cross_reference: NCI_NCI-GLOSS:CDR0000269443
database_cross_reference: NCI_NCI-GLOSS:CDR0000269444
database_cross_reference: PSY:33440
database_cross_reference: PSY:33770
database_cross_reference: SNM:T-X0210
database_cross_reference: SNMI:T-A0210
database_cross_reference: SNOMEDCT_US:47220008

Grid Cells
type: Class
subclass of: Neurons
MCID: MC01054892
PMOID: PMO:00000763
Subclass_of: Neurons
Synonym: Cell, Grid
Synonym: Cells, Grid
Synonym: Grid Cell
Tree Number: T2.23.1
database_cross_reference: MSH:D000071038

Suprachiasmatic Nucleus Neurons
type: Class
subclass of: Neurons
PMOID: PMO:00000764
Subclass_of: Neurons
Tree Number: T2.23.2

Mossy Fibers, Hippocampal
type: Class
subclass of: Axons
MCID: MC00163921
PMOID: PMO:00000765
Subclass_of: Axons
Synonym: Hippocampal Mossy Fiber
Synonym: Hippocampal Mossy Fibers
Synonym: Mossy Fiber, Hippocampal
Synonym: hippocampal mossy fiber
Tree Number: T2.23.3.3
database_cross_reference: GO:GO:0097457
database_cross_reference: MSH:D019599

Interneurons
type: Class
subclass of: Neurons
MCID: MC00006941
PMOID: PMO:00000766
Subclass_of: Neurons
Synonym: Connector Neuron
Synonym: Intercalary Neuron
Synonym: Intercalated Neuron
Synonym: Intercalated Neurons
Synonym: Interneuron
Synonym: Internuncial Cell
Synonym: Internuncial Neuron
Synonym: Neuron, Intercalated
Synonym: Neurons, Intercalated
Synonym: connector neuron
Tree Number: T2.23.5
database_cross_reference: AOD:0000017728
database_cross_reference: AOD:0000028013
database_cross_reference: AOD:0000028015
database_cross_reference: AOD:0000028017
database_cross_reference: AOD:0000028019
database_cross_reference: AOD:0000028020
database_cross_reference: CHV:0000006838
database_cross_reference: CSP:2047-3656
database_cross_reference: FMA:67313
database_cross_reference: MSH:D007395
database_cross_reference: NCI:C12625

Amacrine Cells
type: Class
subclass of: Interneurons
subclass of: Retinal Neurons
MCID: MC00076626
PMOID: PMO:00000767
Subclass_of: Interneurons
Subclass_of: Retinal Neurons
Synonym: Amacrine Cell
Synonym: Amacrine Cell of Retina
Synonym: Amacrine Cells of Retina
Synonym: Amacrine cell
Synonym: Amacrine cell of retina
Synonym: Amacrine cells of retina
Synonym: Amacrine cells of retina (body structure)
Synonym: Cell, Amacrine
Synonym: Cells, Amacrine
Synonym: Retina, amacrine cells
Tree Number: T2.23.5.1
Tree Number: T2.23.9.5.3
database_cross_reference: CSP:1111-4695
database_cross_reference: FMA:67766
database_cross_reference: MSH:D025042
database_cross_reference: NCI:C12626
database_cross_reference: SNM:T-XX675
database_cross_reference: SNMI:T-AA675
database_cross_reference: SNOMEDCT_US:9475001

Retinal Bipolar Cells
type: Class
subclass of: Interneurons
subclass of: Retinal Neurons
MCID: MC00541326
PMOID: PMO:00000768
Subclass_of: Interneurons
Subclass_of: Retinal Neurons
Synonym: Bipolar Cell, Retinal
Synonym: Bipolar Cells, Retinal
Synonym: Bipolar cell of retina
Synonym: Bipolar cells of retina
Synonym: Bipolar cells of retina (body structure)
Synonym: Cell, Retinal Bipolar
Synonym: Cells, Retinal Bipolar
Synonym: Retina, bipolar cells
Synonym: Retinal Bipolar Cell
Tree Number: T2.23.5.2
Tree Number: T2.23.9.5.4
database_cross_reference: FMA:67749
database_cross_reference: MSH:D051245
database_cross_reference: SNM:T-XX671
database_cross_reference: SNMI:T-AA671
database_cross_reference: SNOMEDCT_US:72060002

Renshaw Cells
type: Class
subclass of: Interneurons
MCID: MC00223919
PMOID: PMO:00000769
Subclass_of: Interneurons
Synonym: Cell, Renshaw
Synonym: Cells, Renshaw
Synonym: Interneurons, Renshaw
Synonym: Renshaw Cell
Synonym: Renshaw Interneurons
Synonym: Renshaw cell
Synonym: Spinal Cord Ventral Horn Interneuron Renshaw
Synonym: cells renshaw
Synonym: renshaw cell
Tree Number: T2.23.5.3
database_cross_reference: AOD:0000017731
database_cross_reference: CHV:0000043671
database_cross_reference: FMA:86787
database_cross_reference: MSH:D066293
database_cross_reference: NCI:C33463

Commissural Interneurons
type: Class
subclass of: Interneurons
MCID: MC00976529
PMOID: PMO:00000770
Subclass_of: Interneurons
Synonym: Commissural Interneuron
Synonym: Interneuron, Commissural
Synonym: Interneurons, Commissural
Tree Number: T2.23.5.4
database_cross_reference: MSH:D066294

Nerve Fibers
type: Class
subclass of: Neurons
MCID: MC00008782
PMOID: PMO:00000771
Subclass_of: Neurons
Synonym: Nerve Fiber
Synonym: Nerve fiber
Synonym: Nerve fiber (body structure)
Synonym: Nerve fiber, NOS
Synonym: Nerve fibre
Synonym: Neurofibra
Synonym: Neurofibrum
Synonym: fiber nerve
Synonym: fibers nerve
Synonym: fibres nerve
Tree Number: T2.23.6
database_cross_reference: AOD:0000027997
database_cross_reference: CHV:0000008598
database_cross_reference: FMA:5914
database_cross_reference: GO:GO:0043005
database_cross_reference: MSH:D009412
database_cross_reference: NCI:C32177
database_cross_reference: SNM:T-X0330
database_cross_reference: SNMI:T-A0330
database_cross_reference: SNOMEDCT_US:88545005
database_cross_reference: UWDA:5914

Adrenergic Fibers
type: Class
subclass of: Nerve Fibers
MCID: MC00000435
PMOID: PMO:00000772
Subclass_of: Nerve Fibers
Synonym: Adrenergic Fiber
Synonym: Fiber, Adrenergic
Synonym: Fiber, Sympathetic
Synonym: Fibers, Adrenergic
Synonym: Fibers, Sympathetic
Synonym: Sympathetic Fiber
Synonym: Sympathetic Fibers
Synonym: Sympathetic fiber
Synonym: Sympathetic fiber (body structure)
Synonym: Sympathetic fibre
Tree Number: T2.23.6.1
database_cross_reference: MSH:D000320
database_cross_reference: SNOMEDCT_US:361060001

Sympathetic Fibers, Postganglionic
type: Class
subclass of: Adrenergic Fibers
subclass of: Autonomic Fibers, Postganglionic
MCID: MC00067357
PMOID: PMO:00000773
Subclass_of: Adrenergic Fibers
Subclass_of: Autonomic Fibers, Postganglionic
Synonym: Fiber, Postganglionic Sympathetic
Synonym: Fibers, Postganglionic Sympathetic
Synonym: Postganglionic Sympathetic Fiber
Synonym: Postganglionic Sympathetic Fibers
Synonym: Postganglionic sympathetic fiber
Synonym: Postganglionic sympathetic fibre
Synonym: Structure of postganglionic sympathetic fiber
Synonym: Structure of postganglionic sympathetic fiber (body structure)
Synonym: Structure of postganglionic sympathetic fibre
Synonym: Sympathetic Fiber, Postganglionic
Tree Number: T2.23.6.1.1
Tree Number: T2.23.6.2.2
database_cross_reference: MSH:D017779
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12650
database_cross_reference: SNM:T-X9660
database_cross_reference: SNMI:T-A9660
database_cross_reference: SNOMEDCT_US:44821008

Autonomic Fibers, Postganglionic
type: Class
subclass of: Nerve Fibers
MCID: MC00001400
PMOID: PMO:00000774
Subclass_of: Nerve Fibers
Synonym: Autonomic Fiber, Postganglionic
Synonym: Fiber, Postganglionic Autonomic
Synonym: Fibers, Postganglionic Autonomic
Synonym: Postganglionic Autonomic Fiber
Synonym: Postganglionic Autonomic Fibers
Synonym: Postganglionic Fiber
Synonym: postganglionic fiber
Tree Number: T2.23.6.2
database_cross_reference: CSP:2049-9198
database_cross_reference: MSH:D001338
database_cross_reference: NCI:C12648
database_cross_reference: PSY:39680

Parasympathetic Fibers, Postganglionic
type: Class
subclass of: Autonomic Fibers, Postganglionic
subclass of: Cholinergic Fibers
MCID: MC00067355
PMOID: PMO:00000775
Subclass_of: Autonomic Fibers, Postganglionic
Subclass_of: Cholinergic Fibers
Synonym: Fiber, Postganglionic Parasympathetic
Synonym: Fibers, Postganglionic Parasympathetic
Synonym: Parasympathetic Fiber, Postganglionic
Synonym: Postganglionic Parasympathetic Fiber
Synonym: Postganglionic Parasympathetic Fibers
Tree Number: T2.23.21.1.2
Tree Number: T2.23.6.2.1
Tree Number: T2.23.6.4.2
database_cross_reference: MSH:D017777
database_cross_reference: NCI:C12649

Cholinergic Fibers
type: Class
subclass of: Nerve Fibers
subclass of: Cholinergic Neurons
MCID: MC00002751
PMOID: PMO:00000776
Subclass_of: Cholinergic Neurons
Subclass_of: Nerve Fibers
Synonym: Cholinergic Fiber
Synonym: Fiber, Cholinergic
Synonym: Fibers, Cholinergic
Tree Number: T2.23.21.1
Tree Number: T2.23.6.4
database_cross_reference: MSH:D002799

Autonomic Fibers, Preganglionic
type: Class
subclass of: Cholinergic Fibers
MCID: MC00001401
PMOID: PMO:00000777
Subclass_of: Cholinergic Fibers
Synonym: Autonomic Fiber, Preganglionic
Synonym: Fiber, Preganglionic Autonomic
Synonym: Fibers, Preganglionic Autonomic
Synonym: Preganglionic Autonomic Fiber
Synonym: Preganglionic Autonomic Fibers
Synonym: Preganglionic Fiber
Synonym: preganglionic fiber
Tree Number: T2.23.21.1.1
Tree Number: T2.23.6.4.1
database_cross_reference: CSP:2049-9205
database_cross_reference: MSH:D001339
database_cross_reference: NCI:C12624
database_cross_reference: PSY:40040

Nerve Fibers, Myelinated
type: Class
subclass of: Neurons
subclass of: Nerve Fibers
MCID: MC00008783
PMOID: PMO:00000778
Subclass_of: Nerve Fibers
Subclass_of: Neurons
Synonym: Fiber, Myelinated Nerve
Synonym: Fibers, Myelinated Nerve
Synonym: Myelinated Nerve Fiber
Synonym: Myelinated Nerve Fibers
Synonym: Myelinated nerve fiber
Synonym: Myelinated nerve fiber structure
Synonym: Myelinated nerve fiber structure (body structure)
Synonym: Myelinated nerve fiber, NOS
Synonym: Myelinated nerve fibre
Synonym: Myelinated nerve fibre structure
Tree Number: T2.23.6.5
Tree Number: T2.23.7
database_cross_reference: CHV:0000008599
database_cross_reference: FMA:5915
database_cross_reference: MSH:D009413
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12627
database_cross_reference: SNM:T-X0340
database_cross_reference: SNMI:T-A0340
database_cross_reference: SNOMEDCT_US:54115001
database_cross_reference: UWDA:5915

Nerve Fibers, Unmyelinated
type: Class
subclass of: Nerve Fibers
MCID: MC00158356
PMOID: PMO:00000779
Subclass_of: Nerve Fibers
Synonym: Nerve Fiber, Unmyelinated
Synonym: Non myelinated nerve fiber
Synonym: Non myelinated nerve fiber (body structure)
Synonym: Non myelinated nerve fiber, NOS
Synonym: Non myelinated nerve fibre
Synonym: Non-myelinated nerve fiber
Synonym: Unmyelinated Nerve Fiber
Synonym: Unmyelinated Nerve Fibers
Synonym: Unmyelinated nerve fiber
Tree Number: T2.23.6.6
database_cross_reference: FMA:5916
database_cross_reference: MSH:D036421
database_cross_reference: NCI:C33835
database_cross_reference: SNM:T-X0350
database_cross_reference: SNMI:T-A0350
database_cross_reference: SNOMEDCT_US:46920005
database_cross_reference: UWDA:5916

Neurons, Afferent
type: Class
subclass of: Neurons
MCID: MC00008843
PMOID: PMO:00000780
Subclass_of: Neurons
Synonym: Afferent Neuron
Synonym: Afferent Neurons
Synonym: Afferent neuron
Synonym: Neuron, Afferent
Synonym: Sensory Cell Afferent Neuron
Synonym: Sensory Neuron
Synonym: Sensory Neurons
Synonym: Sensory neuron
Synonym: afferent neuron
Synonym: afferent neurons
Tree Number: T2.23.9
database_cross_reference: AOD:0000017714
database_cross_reference: CHV:0000008659
database_cross_reference: FMA:84649
database_cross_reference: FMA:87653
database_cross_reference: MSH:D009475
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12628
database_cross_reference: PSY:46610

Hair Cells, Auditory
type: Class
subclass of: Neurons, Afferent
MCID: MC00005913
PMOID: PMO:00000781
Subclass_of: Neurons, Afferent
Synonym: Auditory Hair Cell
Synonym: Auditory Hair Cells
Synonym: Auditory receptor
Synonym: Cell, Cochlear Hair
Synonym: Cells, Cochlear Hair
Synonym: Cochlear Hair Cell
Synonym: Cochlear Hair Cells
Synonym: Cochlear hair cell
Synonym: Corti Cell
Synonym: Corti cell
Tree Number: T2.23.9.1
database_cross_reference: AOD:0000017552
database_cross_reference: AOD:0000017628
database_cross_reference: AOD:0000027969
database_cross_reference: CHV:0000005763
database_cross_reference: CSP:0975-3295
database_cross_reference: FMA:62364
database_cross_reference: FMA:84660
database_cross_reference: LCH_NW:sh95005808
database_cross_reference: MSH:D006198
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12629
database_cross_reference: SNM:T-XY780
database_cross_reference: SNMI:T-AB890
database_cross_reference: SNOMEDCT_US:52148002

Hair Cells, Auditory, Inner
type: Class
subclass of: Hair Cells, Auditory
MCID: MC00005914
PMOID: PMO:00000782
Subclass_of: Hair Cells, Auditory
Synonym: Auditory Hair Cell, Inner
Synonym: Auditory Hair Cells, Inner
Synonym: Cell, Inner Hair
Synonym: Cells, Inner Hair
Synonym: Cochlear Inner Hair Cell
Synonym: Cochlear Inner Hair Cells
Synonym: Cochlear inner hair cell
Synonym: Hair Cell, Auditory, Inner
Synonym: Hair Cell, Inner
Synonym: Hair Cells, Inner
Tree Number: T2.23.9.1.1
database_cross_reference: CHV:0000005764
database_cross_reference: FMA:62365
database_cross_reference: MSH:D006199
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32805
database_cross_reference: SNM:T-XY781
database_cross_reference: SNMI:T-AB891
database_cross_reference: SNOMEDCT_US:11520008

Hair Cells, Auditory, Outer
type: Class
subclass of: Hair Cells, Auditory
MCID: MC00527255
PMOID: PMO:00000783
Subclass_of: Hair Cells, Auditory
Synonym: Auditory Hair Cell, Outer
Synonym: Auditory Hair Cells, Outer
Synonym: Cochlear Outer Hair Cell
Synonym: Cochlear Outer Hair Cells
Synonym: Cochlear outer hair cell
Synonym: Hair Cell, Auditory, Outer
Synonym: Hair Cells, Auditory, Outer Inner
Synonym: Hair Cells, Outer
Synonym: Outer Auditory Hair Cell
Synonym: Outer Auditory Hair Cells
Tree Number: T2.23.9.1.2
database_cross_reference: FMA:62366
database_cross_reference: MSH:D018072
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33233
database_cross_reference: SNM:T-XY782
database_cross_reference: SNMI:T-AB892
database_cross_reference: SNOMEDCT_US:43313002

Sensory Receptor Cells
type: Class
subclass of: Neurons, Afferent
MCID: MC00011185
PMOID: PMO:00000784
Subclass_of: Neurons, Afferent
Synonym: NEURAL RECEPT
Synonym: NEURORECEPT
Synonym: Neural Receptor
Synonym: Neural Receptors
Synonym: Neural receptors
Synonym: Neuron, Sensory
Synonym: Neurons, Sensory
Synonym: Neuroreceptor
Synonym: Neuroreceptors
Synonym: Peripheral ending of sensory neuron
Tree Number: T2.23.9.2
database_cross_reference: AOD:0000017550
database_cross_reference: AOD:0000027956
database_cross_reference: CHV:0000010627
database_cross_reference: CSP:4000-0324
database_cross_reference: FMA:84650
database_cross_reference: LCH:U006091
database_cross_reference: LCH_NW:sh88002450
database_cross_reference: MSH:D011984
database_cross_reference: MTH:NOCODE
database_cross_reference: PSY:33620
database_cross_reference: PSY:43300

Chemoreceptor Cells
type: Class
subclass of: Sensory Receptor Cells
MCID: MC00002599
PMOID: PMO:00000785
Subclass_of: Sensory Receptor Cells
Synonym: Cell, Chemoreceptive
Synonym: Cell, Chemoreceptor
Synonym: Cells, Chemoreceptive
Synonym: Cells, Chemoreceptor
Synonym: Chemoreceptive Cell
Synonym: Chemoreceptive Cells
Synonym: Chemoreceptor
Synonym: Chemoreceptor Cell
Synonym: Chemoreceptors
Synonym: chemoreceptor
Tree Number: T2.23.9.2.1
database_cross_reference: AOD:0000017551
database_cross_reference: CHV:0000002744
database_cross_reference: CSP:2681-9596
database_cross_reference: FMA:85604
database_cross_reference: LCH:U000939
database_cross_reference: LCH_NW:sh85023035
database_cross_reference: MSH:D002628
database_cross_reference: MTH:NOCODE
database_cross_reference: PSY:08570

Mechanoreceptors
type: Class
subclass of: Sensory Receptor Cells
MCID: MC00007947
PMOID: PMO:00000792
Subclass_of: Sensory Receptor Cells
Synonym: Auditory Receptor Cell
Synonym: Cell, Mechanoreceptor
Synonym: Cells, Mechanoreceptor
Synonym: MECHANORECEPT
Synonym: Mechanoreceptor
Synonym: Mechanoreceptor Cell
Synonym: Mechanoreceptor Cells
Synonym: mechanoreceptor
Synonym: mechanoreceptors
Tree Number: T2.23.9.2.2
database_cross_reference: CHV:0000007826
database_cross_reference: CSP:2681-9645
database_cross_reference: FMA:86587
database_cross_reference: LCH:U002850
database_cross_reference: LCH_NW:sh85082782
database_cross_reference: MSH:D008465
database_cross_reference: NCI:C13821
database_cross_reference: NCI:C33063
database_cross_reference: PSY:30250

Hair Cells, Vestibular
type: Class
subclass of: Neurons, Afferent
MCID: MC00067437
PMOID: PMO:00000797
Subclass_of: Neurons, Afferent
Synonym: Hair Cell, Vestibular
Synonym: Vestibular Hair Cell
Synonym: Vestibular Hair Cells
Synonym: Vestibular hair cell
Synonym: Vestibular sensory cell
Synonym: equilibrium hair cell
Tree Number: T2.23.9.3
database_cross_reference: AOD:0000017670
database_cross_reference: FMA:62351
database_cross_reference: MSH:D018069
database_cross_reference: NCI:C12632

Nociceptors
type: Class
subclass of: Sensory Receptor Cells
MCID: MC00008972
PMOID: PMO:00000798
Subclass_of: Sensory Receptor Cells
Synonym: NOCICEPT
Synonym: Neuron, Nociceptive
Synonym: Neurons, Nociceptive
Synonym: Nociceptive Neuron
Synonym: Nociceptive Neurons
Synonym: Nociceptor
Synonym: PAIN RECEPT
Synonym: Pain Receptor
Synonym: Pain Receptors
Synonym: RECEPT PAIN
Tree Number: T2.23.9.2.3
database_cross_reference: AOD:0000017655
database_cross_reference: AOD:0000017656
database_cross_reference: CHV:0000008753
database_cross_reference: CSP:5000-0033
database_cross_reference: LCH:U003255
database_cross_reference: LCH_NW:sh85092154
database_cross_reference: MSH:D009619
database_cross_reference: NCI:C13176
database_cross_reference: PSY:34080
database_cross_reference: PSY:36175

Photoreceptor Cells
type: Class
subclass of: Sensory Receptor Cells
subclass of: Retinal Neurons
MCID: MC00010172
PMOID: PMO:00000799
Subclass_of: Retinal Neurons
Subclass_of: Sensory Receptor Cells
Synonym: Cell, Photoreceptor
Synonym: Cells, Photoreceptor
Synonym: PHOTORECEPT CELLS
Synonym: Photoreceptor
Synonym: Photoreceptor Cell
Synonym: Photoreceptor cell
Synonym: Photoreceptors
Synonym: Photosensitive Cell
Synonym: photoreceptor
Synonym: photoreceptors
Tree Number: T2.23.9.2.4
Tree Number: T2.23.9.5.1
database_cross_reference: AOD:0000017585
database_cross_reference: AOD:0000027963
database_cross_reference: CHV:0000009688
database_cross_reference: FMA:85613
database_cross_reference: FMA:86740
database_cross_reference: LCH:U003651
database_cross_reference: LCH_NW:sh85101407
database_cross_reference: MSH:D010786
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12634
database_cross_reference: PSY:38430

Thermoreceptors
type: Class
subclass of: Sensory Receptor Cells
MCID: MC00012697
PMOID: PMO:00000808
Subclass_of: Sensory Receptor Cells
Synonym: THERMORECEPT
Synonym: Thermoreceptor
Synonym: receptors temperature
Synonym: temperature receptor
Synonym: thermoreceptor
Synonym: thermoreceptors
Tree Number: T2.23.9.2.5
database_cross_reference: AOD:0000017654
database_cross_reference: CHV:0000012167
database_cross_reference: CSP:2681-9760
database_cross_reference: LCH:U004649
database_cross_reference: LCH_NW:sh85134815
database_cross_reference: MSH:D013823
database_cross_reference: NCI:C13822
database_cross_reference: PSY:52840

Posterior Horn Cells
type: Class
subclass of: Neurons, Afferent
MCID: MC00259164
PMOID: PMO:00000809
Subclass_of: Neurons, Afferent
Synonym: Cell, Dorsal Horn
Synonym: Cell, Posterior Horn
Synonym: Cells, Dorsal Horn
Synonym: Cells, Posterior Horn
Synonym: Dorsal Horn Cell
Synonym: Dorsal Horn Cells
Synonym: Dorsal Horn Neuron
Synonym: Dorsal Horn Neurons
Synonym: Neuron, Dorsal Horn
Synonym: Neuron, Posterior Horn
Tree Number: T2.23.9.4
database_cross_reference: MSH:D020671
database_cross_reference: NCI:C12640

Substantia Gelatinosa
type: Class
subclass of: Posterior Horn Cells
MCID: MC00012327
PMOID: PMO:00000810
Subclass_of: Posterior Horn Cells
Synonym: Gelatinosa, Substantia
Synonym: Gelatinosas, Substantia
Synonym: Gelatinous substance of Rolando
Synonym: Gelatinous substance of posterior horn of spinal cord
Synonym: II
Synonym: Lamina 2
Synonym: Lamina II
Synonym: Lamina spinalis II
Synonym: Rexed's lamina II
Synonym: Rolando Substantia Gelatinosa
Tree Number: T2.23.9.4.1
database_cross_reference: FMA:74019
database_cross_reference: MSH:D013376
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12641
database_cross_reference: NEU:1635
database_cross_reference: RCD:Xa1PQ
database_cross_reference: SNM:T-X7432
database_cross_reference: SNMI:T-A7032
database_cross_reference: SNOMEDCT_US:280409008
database_cross_reference: SNOMEDCT_US:33138000

Retinal Neurons
type: Class
subclass of: Neurons, Afferent
MCID: MC00715405
PMOID: PMO:00000811
Subclass_of: Neurons, Afferent
Synonym: Neuron, Retinal
Synonym: Neurons, Retinal
Synonym: Retinal Neuron
Tree Number: T2.23.9.5
database_cross_reference: MSH:D055351

Retinal Ganglion Cells
type: Class
subclass of: Retinal Neurons
MCID: MC00011309
PMOID: PMO:00000812
Subclass_of: Retinal Neurons
Synonym: Cell, Retinal Ganglion
Synonym: Cells, Retinal Ganglion
Synonym: Ganglion Cell, Retinal
Synonym: Ganglion Cells (Retina)
Synonym: Ganglion Cells, Retinal
Synonym: Ganglion cell of retina
Synonym: Retinal Ganglion Cell
Synonym: Retinal ganglion cell
Synonym: Retinal ganglion cells
Synonym: retinal ganglion
Tree Number: T2.23.9.5.2
database_cross_reference: CHV:0000010799
database_cross_reference: CSP:1112-0001
database_cross_reference: FMA:67765
database_cross_reference: LCH:U004108
database_cross_reference: LCH_NW:sh85113334
database_cross_reference: MSH:D012165
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12642
database_cross_reference: PSY:20615
database_cross_reference: PSY:44440

Retinal Horizontal Cells
type: Class
subclass of: Retinal Neurons
MCID: MC00541328
PMOID: PMO:00000813
Subclass_of: Retinal Neurons
Synonym: Cell, Retinal Horizontal
Synonym: Cells, Retinal Horizontal
Synonym: Horizontal Cell, Retinal
Synonym: Horizontal Cells, Retinal
Synonym: Retinal Horizontal Cell
Tree Number: T2.23.9.5.5
database_cross_reference: MSH:D051248

Neurons, Efferent
type: Class
subclass of: Neurons
MCID: MC00008844
PMOID: PMO:00000814
Subclass_of: Neurons
Synonym: Efferent Nerve
Synonym: Efferent Neuron
Synonym: Efferent Neurons
Synonym: Motoneuron
Synonym: Motor Neurons
Synonym: Neuron, Efferent
Synonym: efferent nerve
Synonym: efferent neuron
Tree Number: T2.23.10
database_cross_reference: AOD:0000017717
database_cross_reference: CSP:2045-5033
database_cross_reference: MSH:D009476
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12643
database_cross_reference: NCI:C12644

Motor Neurons
type: Class
subclass of: Neurons, Efferent
MCID: MC00008427
PMOID: PMO:00000815
Subclass_of: Neurons, Efferent
Synonym: Motoneuron
Synonym: Motoneurons
Synonym: Motor Neuron
Synonym: Motor neuron
Synonym: Motor neuron (cell)
Synonym: Motor neurons
Synonym: Neuron, Motor
Synonym: Neurons, Motor
Synonym: motoneuron
Synonym: motoneurons
Tree Number: T2.23.10.1
database_cross_reference: AOD:0000017718
database_cross_reference: AOD:0000017719
database_cross_reference: AOD:0000028008
database_cross_reference: CHV:0000008277
database_cross_reference: CSP:2057-4197
database_cross_reference: FMA:83617
database_cross_reference: LCH:U003033
database_cross_reference: LCH_NW:sh85087586
database_cross_reference: MSH:D009046
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12644
database_cross_reference: PSY:32290
database_cross_reference: SNMI:T-A0390
database_cross_reference: SNOMEDCT_US:31513005

Anterior Horn Cells
type: Class
subclass of: Motor Neurons
MCID: MC00000974
PMOID: PMO:00000816
Subclass_of: Motor Neurons
Synonym: Anterior Horn Cell
Synonym: Anterior Horn Neuron
Synonym: Anterior Horn Neurons
Synonym: Cell, Anterior Horn
Synonym: Cell, Ventral Horn
Synonym: Cells, Anterior Horn
Synonym: Cells, Ventral Horn
Synonym: Neuron, Anterior Horn
Synonym: Neuron, Ventral Horn
Synonym: Neurons, Anterior Horn
Tree Number: T2.23.10.1.1
database_cross_reference: CHV:0000001237
database_cross_reference: MSH:D000870
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12645

Motor Neurons, Gamma
type: Class
subclass of: Motor Neurons
MCID: MC00008428
PMOID: PMO:00000817
Subclass_of: Motor Neurons
Synonym: Fusimotor Neuron
Synonym: Fusimotor Neurons
Synonym: Gamma Motor Neuron
Synonym: Gamma Motor Neurons
Synonym: Gamma Motorneuron
Synonym: Gamma Motorneurons
Synonym: Gamma motor neuron
Synonym: Gamma-Efferent Motor Neuron
Synonym: Gamma-Efferent Motor Neurons
Synonym: Motor Neuron, Gamma
Tree Number: T2.23.10.1.2
database_cross_reference: FMA:83660
database_cross_reference: MSH:D009047
database_cross_reference: NCI:C12646

Purkinje Cells
type: Class
subclass of: Neurons
MCID: MC00010932
PMOID: PMO:00000818
Subclass_of: Neurons
Synonym: Cell, Purkinje
Synonym: Cell, Purkyne
Synonym: Cells, Purkinje
Synonym: Cells, Purkyne
Synonym: Cerebellar Purkinje Cell
Synonym: Neuron, Purkinje
Synonym: Neurons, Purkinje
Synonym: Purkinje Cell
Synonym: Purkinje Neuron
Synonym: Purkinje Neurons
Tree Number: T2.23.12
database_cross_reference: AOD:0000017744
database_cross_reference: AOD:0000028024
database_cross_reference: CHV:0000010418
database_cross_reference: CSP:0480-1109
database_cross_reference: FMA:67969
database_cross_reference: LCH:U003956
database_cross_reference: LCH_NW:sh85109202
database_cross_reference: LNC:LP17260-8
database_cross_reference: MSH:D011689
database_cross_reference: NCI:C12651
database_cross_reference: PSY:42385
database_cross_reference: SNM:T-X0300
database_cross_reference: SNMI:T-A0300
database_cross_reference: SNOMEDCT_US:83626009

Pyramidal Cells
type: Class
subclass of: Neurons
MCID: MC00067400
PMOID: PMO:00000819
Subclass_of: Neurons
Synonym: Cell, Pyramidal
Synonym: Cells, Pyramidal
Synonym: Neuron, Pyramidal
Synonym: Neurons, Pyramidal
Synonym: Pyramidal Cell
Synonym: Pyramidal Neuron
Synonym: Pyramidal Neurons
Synonym: Pyramidal cell
Synonym: Pyramidal cell (body structure)
Synonym: Pyramidal cell (cell)
Tree Number: T2.23.15
database_cross_reference: CSP:0480-5018
database_cross_reference: MSH:D017966
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12652
database_cross_reference: SNM:T-X0221
database_cross_reference: SNMI:T-A0221
database_cross_reference: SNOMEDCT_US:17522008

Place Cells
type: Class
subclass of: Pyramidal Cells
MCID: MC01054858
PMOID: PMO:00000820
Subclass_of: Pyramidal Cells
Synonym: Cell, Hippocampal Place
Synonym: Cell, Place
Synonym: Cells, Hippocampal Place
Synonym: Cells, Place
Synonym: Hippocampal Place Cell
Synonym: Hippocampal Place Cells
Synonym: Place Cell
Synonym: Place Cell, Hippocampal
Synonym: Place Cells, Hippocampal
Tree Number: T2.23.15.1
database_cross_reference: MSH:D000071037

Nitrergic Neurons
type: Class
subclass of: Neurons
MCID: MC00337803
PMOID: PMO:00000821
Subclass_of: Neurons
Synonym: Neuron, Nitrergic
Synonym: Neuron, Nitroxidergic
Synonym: Neurons, Nitrergic
Synonym: Neurons, Nitroxidergic
Synonym: Nitrergic Neuron
Synonym: Nitrergic neuron
Synonym: Nitroxidergic Neuron
Synonym: Nitroxidergic Neurons
Tree Number: T2.23.17
database_cross_reference: FMA:84792
database_cross_reference: MSH:D026602
database_cross_reference: NCI:C12647

Mirror Neurons
type: Class
subclass of: Neurons
MCID: MC00830965
PMOID: PMO:00000822
Subclass_of: Neurons
Synonym: Mirror Neuron
Synonym: Mirror neurons
Synonym: Neuron, Mirror
Synonym: Neurons, Mirror
Tree Number: T2.23.18
database_cross_reference: LCH_NW:sh2006009040
database_cross_reference: MSH:D059167

Dopaminergic Neurons
type: Class
subclass of: Neurons
MCID: MC00523688
PMOID: PMO:00000823
Subclass_of: Neurons
Synonym: Dopamine Neuron
Synonym: Dopamine Neurons
Synonym: Dopaminergic Cell
Synonym: Dopaminergic Neuron
Synonym: Dopaminergic cell
Synonym: Dopaminergic cells
Synonym: Dopaminergic cells set
Synonym: Dopaminergic neuron
Synonym: Dopaminergic neurons
Synonym: Neuron, Dopamine
Tree Number: T2.23.19
database_cross_reference: AOD:0000017749
database_cross_reference: AOD:0000028025
database_cross_reference: CHV:0000049346
database_cross_reference: FMA:78545
database_cross_reference: FMA:84787
database_cross_reference: LCH_NW:sh00000066
database_cross_reference: MSH:D059290
database_cross_reference: NCI:C26454

Serotonergic Neurons
type: Class
subclass of: Neurons
MCID: MC00830978
PMOID: PMO:00000824
Subclass_of: Neurons
Synonym: Neuron, Serotonergic
Synonym: Neuron, Serotoninergic
Synonym: Neurons, Serotonergic
Synonym: Neurons, Serotoninergic
Synonym: Serotonergic Neuron
Synonym: Serotoninergic Neuron
Synonym: Serotoninergic Neurons
Tree Number: T2.23.20
database_cross_reference: MSH:D059326

Cholinergic Neurons
type: Class
subclass of: Neurons
MCID: MC00706391
PMOID: PMO:00000825
Subclass_of: Neurons
Synonym: Cholinergic Neuron
Synonym: Cholinergic neuron
Synonym: Neuron, Cholinergic
Synonym: Neurons, Cholinergic
Tree Number: T2.23.21
database_cross_reference: FMA:84796
database_cross_reference: MSH:D059329

GABAergic Neurons
type: Class
subclass of: Neurons
MCID: MC00277082
PMOID: PMO:00000826
Subclass_of: Neurons
Synonym: Cell, GABA
Synonym: Cells, GABA
Synonym: GABA Cell
Synonym: GABA Cells
Synonym: GABA Neuron
Synonym: GABA Neurons
Synonym: GABA-ergic neuron
Synonym: GABAergic Neuron
Synonym: GABAergic neuron
Synonym: Neuron, GABA
Tree Number: T2.23.22
database_cross_reference: AOD:0000017747
database_cross_reference: FMA:84788
database_cross_reference: MSH:D059330

Adrenergic Neurons
type: Class
subclass of: Neurons
MCID: MC00830979
PMOID: PMO:00000827
Subclass_of: Neurons
Synonym: Adrenergic Neuron
Synonym: Neuron, Adrenergic
Synonym: Neurons, Adrenergic
Tree Number: T2.23.23
database_cross_reference: MSH:D059331

Oxyphil Cells
type: Class
subclass of: Cell
MCID: MC00337757
PMOID: PMO:00000828
Subclass_of: Cell
Synonym: Askenazy Cells
Synonym: Cells, Oxyphil
Synonym: Oncocyte
Synonym: Oncocytes
Synonym: Oxyphil Cell
Synonym: Oxyphil cell
Synonym: Oxyphilic Cell
Synonym: oncocyte
Synonym: oncocytes
Synonym: oxyphil cell
Tree Number: T2.24
database_cross_reference: CHV:0000053430
database_cross_reference: FMA:67606
database_cross_reference: FMA:86658
database_cross_reference: MSH:D024862
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12654
database_cross_reference: UWDA:67606

Pancreatic Stellate Cells
type: Class
subclass of: Cell
MCID: MC00798028
PMOID: PMO:00000829
Subclass_of: Cell
Synonym: Cell, Pancreatic Stellate
Synonym: Cells, Pancreatic Stellate
Synonym: PSC
Synonym: PSCs
Synonym: PaSC
Synonym: PaSCs
Synonym: Pancreatic Stellate Cell
Synonym: Stellate Cell, Pancreatic
Synonym: Stellate Cells, Pancreatic
Tree Number: T2.25
database_cross_reference: MSH:D058954
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C107531

Phagocytes
type: Class
subclass of: Cell
MCID: MC00009978
PMOID: PMO:00000830
Subclass_of: Cell
Synonym: Cell, Phagocytic
Synonym: Cells, Phagocytic
Synonym: Phagocyte
Synonym: Phagocyte, NOS
Synonym: Phagocytic Cell
Synonym: Phagocytic Cells
Synonym: Phagocytic cell
Synonym: Phagocytic cell (body structure)
Synonym: Phagocytic cell (cell)
Synonym: Phagocytic cell, NOS
Tree Number: T2.27
database_cross_reference: AOD:0000017482
database_cross_reference: CHV:0000009567
database_cross_reference: CSP:0605-5617
database_cross_reference: FMA:83806
database_cross_reference: LCH:U003589
database_cross_reference: LCH_NW:sh85100548
database_cross_reference: MSH:D010586
database_cross_reference: NCI:C12657
database_cross_reference: NCI_NCI-GLOSS:CDR0000043979
database_cross_reference: SNM:M-69510
database_cross_reference: SNMI:M-62400
database_cross_reference: SNOMEDCT_US:73568005

Plant Cells
type: Class
subclass of: Cell
PMOID: PMO:00000831
Subclass_of: Cell
Tree Number: T2.28

Prokaryotic Cells
type: Class
subclass of: Cell
PMOID: PMO:00000832
Subclass_of: Cell
Tree Number: T2.29

Protoplasts
type: Class
subclass of: Cell
MCID: MC00010810
PMOID: PMO:00000833
Subclass_of: Cell
Synonym: Protoplast
Synonym: protoplast
Tree Number: T2.30
database_cross_reference: CHV:0000010263
database_cross_reference: CSP:0605-5721
database_cross_reference: GO:GO:0005622
database_cross_reference: GO:GO:0044464
database_cross_reference: LCH:U003886
database_cross_reference: LCH_NW:sh85107805
database_cross_reference: MSH:D011523
database_cross_reference: NCI:C12659

Reed-Sternberg Cells
type: Class
subclass of: Cell
MCID: MC00043165
PMOID: PMO:00000834
Subclass_of: Cell
Synonym: Cells, Reed-Sternberg
Synonym: Cells, Sternberg-Reed
Synonym: R-S Cell
Synonym: Reed Sternberg Cells
Synonym: Reed-Sternberg Cell
Synonym: Reed-Sternberg cell
Synonym: Reed-Sternberg cell (body structure)
Synonym: Reed-Sternberg cell (cell)
Synonym: Sternberg Reed Cells
Synonym: Sternberg-Reed Cells
Tree Number: T2.31
database_cross_reference: CHV:0000015454
database_cross_reference: MSH:D016539
database_cross_reference: NCI:C12660
database_cross_reference: NCI_NCI-GLOSS:CDR0000046557
database_cross_reference: SNMI:M-64550
database_cross_reference: SNOMEDCT_US:32915009

Spheroplasts
type: Class
subclass of: Cell
MCID: MC00012116
PMOID: PMO:00000835
Subclass_of: Cell
Synonym: Spheroplast
Synonym: spheroplast
Synonym: spheroplasts
Tree Number: T2.32
database_cross_reference: CHV:0000011599
database_cross_reference: CSP:0605-5721
database_cross_reference: LCH:U004424
database_cross_reference: LCH_NW:sh85126602
database_cross_reference: MSH:D013104
database_cross_reference: NCI:C12661

Spores
type: Class
subclass of: Cell
PMOID: PMO:00000836
Subclass_of: Cell
Tree Number: T2.33

Spores, Bacterial
type: Class
subclass of: Spores
PMOID: PMO:00000837
Subclass_of: Spores
Tree Number: T2.33.1

Spores, Fungal
type: Class
subclass of: Spores
PMOID: PMO:00000838
Subclass_of: Spores
Tree Number: T2.33.2

Spores, Protozoan
type: Class
subclass of: Spores
PMOID: PMO:00000839
Subclass_of: Spores
Tree Number: T2.33.3

Oocysts
type: Class
subclass of: Spores, Protozoan
PMOID: PMO:00000840
Subclass_of: Spores, Protozoan
Tree Number: T2.33.3.1

Sporozoites
type: Class
subclass of: Oocysts
PMOID: PMO:00000841
Subclass_of: Oocysts
Tree Number: T2.33.3.1.1

Schizonts
type: Class
subclass of: Spores, Protozoan
PMOID: PMO:00000842
Subclass_of: Spores, Protozoan
Tree Number: T2.33.3.2

Merozoites
type: Class
subclass of: Schizonts
PMOID: PMO:00000843
Subclass_of: Schizonts
Tree Number: T2.33.3.2.1

Trophozoites
type: Class
subclass of: Spores, Protozoan
PMOID: PMO:00000844
Subclass_of: Spores, Protozoan
Tree Number: T2.33.3.3

Stem Cells
type: Class
subclass of: Cell
MCID: MC00012215
PMOID: PMO:00000845
Subclass_of: Cell
Synonym: Cell, Mother
Synonym: Cell, Progenitor
Synonym: Cell, Stem
Synonym: Cells, Mother
Synonym: Cells, Progenitor
Synonym: Cells, Stem
Synonym: Mother Cell
Synonym: Mother Cells
Synonym: Mother cell
Synonym: Progenitor Cell
Tree Number: T2.34
database_cross_reference: AOD:0000016827
database_cross_reference: CHV:0000011716
database_cross_reference: CSP:4009-0065
database_cross_reference: FMA:63368
database_cross_reference: LCH:U004471
database_cross_reference: LCH_NW:sh85127923
database_cross_reference: MEDLINEPLUS:1395
database_cross_reference: MSH:D013234
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12662
database_cross_reference: NCI_NCI-GLOSS:CDR0000046598
database_cross_reference: RCD:X80Vi
database_cross_reference: SNM:T-06011
database_cross_reference: SNMI:T-C0106
database_cross_reference: SNOMEDCT_US:419758009
database_cross_reference: SNOMEDCT_US:50312002
database_cross_reference: UWDA:63368

Oogonial Stem Cells
type: Class
subclass of: Stem Cells
MCID: MC01054782
PMOID: PMO:00000846
Subclass_of: Stem Cells
Synonym: Female Germline Stem Cells
Synonym: Oogonial Stem Cell
Synonym: Ovarian Germline Stem Cells
Synonym: Stem Cell, Oogonial
Synonym: Stem Cells, Oogonial
Tree Number: T2.34.1
database_cross_reference: MSH:D000072977

Peripheral Blood Stem Cells
type: Class
subclass of: Hematopoietic Stem Cells
MCID: MC00527447
PMOID: PMO:00000847
Subclass_of: Hematopoietic Stem Cells
Synonym: PBSC
Synonym: Peripheral Blood Stem Cell
Synonym: Peripheral Stem Cell
Synonym: Peripheral Stem Cells
Synonym: Peripheral blood stem cell
Synonym: Peripheral blood stem cell (cell)
Synonym: Stem Cell, Peripheral
Synonym: Stem Cells, Peripheral
Synonym: cell peripheral stem
Synonym: peripheral stem cell
Tree Number: T2.34.2.1
database_cross_reference: CHV:0000042696
database_cross_reference: FMA:86711
database_cross_reference: MSH:D000072916
database_cross_reference: NCI:C12946
database_cross_reference: NCI_NCI-GLOSS:CDR0000045828
database_cross_reference: SNOMEDCT_US:419583006

Neoplastic Stem Cells
type: Class
subclass of: Stem Cells
MCID: MC00629049
PMOID: PMO:00000848
Subclass_of: Stem Cells
Synonym: Cell, Neoplastic Stem
Synonym: Cell, Tumor Initiating
Synonym: Cell, Tumor Stem
Synonym: Cells, Neoplastic Stem
Synonym: Cells, Tumor Initiating
Synonym: Cells, Tumor Stem
Synonym: Initiating Cell, Tumor
Synonym: Initiating Cells, Tumor
Synonym: NEOPL STEM CELLS
Synonym: Neoplastic Stem Cell
Tree Number: T2.34.3
database_cross_reference: CHV:0000012660
database_cross_reference: MSH:D014411

Myoblasts
type: Class
subclass of: Stem Cells
MCID: MC00182860
PMOID: PMO:00000849
Subclass_of: Stem Cells
Synonym: Embryonic Muscle Cell
Synonym: Embryonic Muscle Cells
Synonym: Muscle Cell, Embryonic
Synonym: Muscle Cell, Precursor
Synonym: Muscle Cells, Embryonic
Synonym: Muscle Cells, Precursor
Synonym: Myoblast
Synonym: Precursor Muscle Cell
Synonym: Precursor Muscle Cells
Synonym: myoblast
Tree Number: T2.34.4
database_cross_reference: CHV:0000041657
database_cross_reference: CSP:1975-6415
database_cross_reference: FMA:70335
database_cross_reference: LCH_NW:sh90003813
database_cross_reference: MSH:D032446
database_cross_reference: NCI:C33151
database_cross_reference: UWDA:70335

Myoblasts, Smooth Muscle
type: Class
subclass of: Myoblasts
MCID: MC00377761
PMOID: PMO:00000850
Subclass_of: Myoblasts
Synonym: Myoblast, Smooth Muscle
Synonym: Smooth Muscle Myoblast
Synonym: Smooth Muscle Myoblasts
Synonym: Smooth muscle myoblast
Tree Number: T2.34.4.2
database_cross_reference: FMA:84798
database_cross_reference: MSH:D032390

Myoblasts, Skeletal
type: Class
subclass of: Myoblasts
MCID: MC00377762
PMOID: PMO:00000851
Subclass_of: Myoblasts
Synonym: Myoblast, Skeletal
Synonym: Skeletal Myoblast
Synonym: Skeletal Myoblasts
Synonym: Skeletal myoblast
Synonym: myoblast skeletal
Synonym: skeletal myoblast
Tree Number: T2.34.4.3
database_cross_reference: CHV:0000054913
database_cross_reference: FMA:84799
database_cross_reference: MSH:D032448

Satellite Cells, Skeletal Muscle
type: Class
subclass of: Myoblasts, Skeletal
MCID: MC00377763
PMOID: PMO:00000852
Subclass_of: Myoblasts, Skeletal
Synonym: Cell, Myogenic Satellite
Synonym: Cells, Myogenic Satellite
Synonym: Myogenic Satellite Cell
Synonym: Myogenic Satellite Cells
Synonym: Satellite Cell, Myogenic
Synonym: Satellite Cells, Myogenic
Synonym: Skeletal Muscle Satellite Cells
Tree Number: T2.34.4.3.1
database_cross_reference: MSH:D032496

Totipotent Stem Cells
type: Class
subclass of: Stem Cells
MCID: MC00304877
PMOID: PMO:00000853
Subclass_of: Stem Cells
Synonym: Cell, Totipotent Stem
Synonym: Cells, Totipotent Stem
Synonym: Stem Cell, Totipotent
Synonym: Stem Cells, Totipotent
Synonym: Totipotent Stem Cell
Synonym: Totipotent stem cell
Synonym: Totipotential stem cell
Synonym: totipotent stem cell
Tree Number: T2.34.5
database_cross_reference: CSP:4001-0045
database_cross_reference: CSP:4009-0065
database_cross_reference: FMA:84790
database_cross_reference: MSH:D039901
database_cross_reference: NCI:C12978

Multipotent Stem Cells
type: Class
subclass of: Stem Cells
MCID: MC00377926
PMOID: PMO:00000854
Subclass_of: Stem Cells
Synonym: Multipotent Stem Cell
Synonym: Multipotent cell
Synonym: Multipotent stem cell
Synonym: Multipotent stem cells
Synonym: Multipotential stem cell
Synonym: Stem Cell, Multipotent
Synonym: Stem Cells, Multipotent
Synonym: multipotent cell
Tree Number: T2.34.6
database_cross_reference: CSP:4009-0066
database_cross_reference: FMA:84789
database_cross_reference: LCH_NW:sh2010012755
database_cross_reference: MSH:D039902
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C43419

Pluripotent Stem Cells
type: Class
subclass of: Stem Cells
MCID: MC00304795
PMOID: PMO:00000855
Subclass_of: Stem Cells
Synonym: Pluripotent Stem Cell
Synonym: Pluripotent stem cell
Synonym: Pluripotential stem cell
Synonym: Stem Cell, Pluripotent
Synonym: Stem Cells, Pluripotent
Synonym: pluripotent stem cell
Synonym: pluripotent stem cells
Tree Number: T2.34.7
database_cross_reference: CHV:0000051524
database_cross_reference: CSP:4009-0066
database_cross_reference: FMA:70570
database_cross_reference: MSH:D039904
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12977
database_cross_reference: NCI_NCI-GLOSS:CDR0000044797
database_cross_reference: UWDA:70570

Embryonic Stem Cells
type: Class
subclass of: Pluripotent Stem Cells
MCID: MC00182646
PMOID: PMO:00000856
Subclass_of: Pluripotent Stem Cells
Synonym: Cell, Embryonic Stem
Synonym: Cells, Embryonic Stem
Synonym: ES cell
Synonym: Embryonic Stem Cell
Synonym: Embryonic stem cell
Synonym: Embryonic stem cell (cell)
Synonym: Embryonic stem cells
Synonym: Stem Cell, Embryonic
Synonym: Stem Cells, Embryonic
Synonym: cell embryonic stem
Tree Number: T2.34.7.1
database_cross_reference: CHV:0000041562
database_cross_reference: CSP:4001-0045
database_cross_reference: FMA:82841
database_cross_reference: LCH_NW:sh92005532
database_cross_reference: MSH:D053595
database_cross_reference: NCI:C12935
database_cross_reference: SNOMEDCT_US:419965008

Human Embryonic Stem Cells
type: Class
subclass of: Embryonic Stem Cells
MCID: MC00397340
PMOID: PMO:00000857
Subclass_of: Embryonic Stem Cells
Synonym: Cells, Human Embryonic Stem
Synonym: Human Embryonic Stem Cell
Synonym: Stem Cells, Human Embryonic
Synonym: cells embryonic human stem
Synonym: hESCs
Synonym: human embryonic stem cell
Tree Number: T2.34.7.1.1
database_cross_reference: CHV:0000055767
database_cross_reference: CSP:5002-0013
database_cross_reference: MSH:D000066449

Mouse Embryonic Stem Cells
type: Class
subclass of: Embryonic Stem Cells
PMOID: PMO:00000858
Subclass_of: Embryonic Stem Cells
Tree Number: T2.34.7.1.2

Embryoid Bodies
type: Class
subclass of: Embryonic Stem Cells
MCID: MC00797953
PMOID: PMO:00000859
Subclass_of: Embryonic Stem Cells
Synonym: Bodies, Embryoid
Synonym: Body, Embryoid
Synonym: Embryoid Body
Tree Number: T2.34.7.1.6
database_cross_reference: MSH:D058732

Induced Pluripotent Stem Cells
type: Class
subclass of: Pluripotent Stem Cells
subclass of: Adult Stem Cells
MCID: MC00747832
PMOID: PMO:00000860
Subclass_of: Adult Stem Cells
Subclass_of: Pluripotent Stem Cells
Synonym: Cell, IPS
Synonym: Cells, IPS
Synonym: IPS Cell
Synonym: IPS Cells
Synonym: Induced Pluripotent Stem Cell
Synonym: iPSC
Tree Number: T2.34.7.2
Tree Number: T2.34.9.2
database_cross_reference: MSH:D057026
database_cross_reference: NCI:C124144

Fetal Stem Cells
type: Class
subclass of: Stem Cells
MCID: MC00583213
PMOID: PMO:00000861
Subclass_of: Stem Cells
Synonym: Cell, Fetal Stem
Synonym: Cells, Fetal Stem
Synonym: Fetal Stem Cell
Synonym: Stem Cell, Fetal
Synonym: Stem Cells, Fetal
Tree Number: T2.34.8
database_cross_reference: MSH:D053686

Adult Stem Cells
type: Class
subclass of: Stem Cells
MCID: MC00397333
PMOID: PMO:00000862
Subclass_of: Stem Cells
Synonym: 'Adult' stem cell
Synonym: Adult Somatic Stem Cells
Synonym: Adult Stem Cell
Synonym: Somatic Adult Stem Cells
Synonym: Somatic Stem Cell
Synonym: Somatic Stem Cells
Synonym: Somatic stem cell
Synonym: Somatic stem cell (cell)
Synonym: Stem Cell, Somatic
Synonym: Stem Cells, Adult
Tree Number: T2.34.9
database_cross_reference: CHV:0000055761
database_cross_reference: CSP:4009-0065
database_cross_reference: MSH:D053687
database_cross_reference: NCI:C43420
database_cross_reference: SNOMEDCT_US:417904004

Adult Germline Stem Cells
type: Class
subclass of: Adult Stem Cells
MCID: MC00943917
PMOID: PMO:00000863
Subclass_of: Adult Stem Cells
Synonym: Germline Adult Stem Cells
Synonym: Progenitor Cells, Spermatogonial
Synonym: Spermatogonial Progenitor Cell
Synonym: Spermatogonial Progenitor Cells
Tree Number: T2.34.9.1
database_cross_reference: MSH:D000072956

Neural Stem Cells
type: Class
subclass of: Stem Cells
MCID: MC00368808
PMOID: PMO:00000864
Subclass_of: Stem Cells
Synonym: Cell, Neural Stem
Synonym: Cells, Neural Stem
Synonym: Neural Stem Cell
Synonym: Neural stem cell
Synonym: Neural stem cells
Synonym: Stem Cell, Neural
Synonym: Stem Cells, Neural
Synonym: cells nerve stem
Synonym: nerve stem cell
Tree Number: T2.34.10
database_cross_reference: CHV:0000054748
database_cross_reference: CSP:5000-0038
database_cross_reference: FMA:86684
database_cross_reference: LCH_NW:sh2003001310
database_cross_reference: MSH:D058953
database_cross_reference: NCI:C12985

Side-Population Cells
type: Class
subclass of: Stem Cells
MCID: MC00798031
PMOID: PMO:00000865
Subclass_of: Stem Cells
Synonym: Cell, Side-Population
Synonym: Cells, Side-Population
Synonym: Side Population Cells
Synonym: Side-Population Cell
Tree Number: T2.34.11
database_cross_reference: MSH:D058985

Phenotypic Abnormality
type: Class
subclass of: Thing
Definition: A phenotypic abnormality.
MCID: MC01000368
PMOID: PMO:00000866
Subclass_of: owl:Thing
Synonym: Organ abnormality
Synonym: Phenotypic abnormality
Tree Number: T3
database_cross_reference: HPO:HP:0000118

Abnormal cellular phenotype
type: Class
subclass of: Phenotypic Abnormality
Definition: An anomaly of cellular morphology or physiology.
MCID: MC01395803
PMOID: PMO:00000867
Subclass_of: Phenotypic Abnormality
Tree Number: T3.1
database_cross_reference: HPO:HP:0025354

Abnormal cell morphology
type: Class
subclass of: Abnormal cellular phenotype
Definition: Any anomaly of cell structure.
MCID: MC01395801
PMOID: PMO:00000868
Subclass_of: Abnormal cellular phenotype
Tree Number: T3.1.1
database_cross_reference: HPO:HP:0025461

Abnormal buccal mucosa cell morphology
type: Class
subclass of: Abnormal cell morphology
Definition: Any structural anomaly of the cells of the mucosa of the oral cavity in the region of the cheek (buccal mucosa cells).
MCID: MC01395783
PMOID: PMO:00000869
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.1
database_cross_reference: HPO:HP:0031476

Abnormal cardiomyocyte morphology
type: Class
subclass of: Abnormal cell morphology
Definition: Any structural anomaly of cardiomyocytes, which are terminally differentiated muscle cells in the heart that are interconnected end to end by gap junctions, which allows coordinated contraction of heart tissue.
MCID: MC01395796
PMOID: PMO:00000871
Subclass_of: Abnormal cell morphology
Synonym: Abnormal cardiac muscle cell morphology
Tree Number: T3.1.1.2
database_cross_reference: HPO:HP:0031331

Abnormal chromosome morphology
type: Class
subclass of: Abnormal cell morphology
Definition: Any structural anomaly of a chromosome, which is a thread like molecule consisting of DNA and proteins (chromatin) that contains DNA sequences for genes and other genetic elements in linear order.
MCID: MC01395810
PMOID: PMO:00000882
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.3
database_cross_reference: HPO:HP:0031411

Abnormal Langerhans cell morphology
type: Class
subclass of: Abnormal cell morphology
Definition: Any functional anomaly of Langerhans cells, which are dendritic cells in the epidermis and some other locations. Langerhans cells play roles iin immune surveillance and homeostasis.
MCID: MC01395954
PMOID: PMO:00000885
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.4
database_cross_reference: HPO:HP:0031871

Abnormal lysosomal morphology
type: Class
subclass of: Abnormal cell morphology
Definition: A structural anomaly of lysosomes, membrane-enclosed organelles that contain an array of enzymes capable of catabolizing proteins, nucleic acids, carbohydrates, and lipids.
MCID: MC01395986
PMOID: PMO:00000887
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.5
database_cross_reference: HPO:HP:0031340

Rosette
type: Class
subclass of: Abnormal cell morphology
Definition: A halo or spoke-wheel arrangement of cells surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core; the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub.
MCID: MC01400983
PMOID: PMO:00000889
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.6
database_cross_reference: HPO:HP:0031925

Abnormal flow cytometry test rest
type: Class
subclass of: Abnormal cellular phenotype
Definition: Any abnormal result of flow cytometry, a method that suspends cells in a stream of fluid and passes them through an electronic detection apparatus in order to assess cell count or measure biomarkers or surface molecules.
MCID: MC01395893
PMOID: PMO:00000895
Subclass_of: Abnormal cellular phenotype
Tree Number: T3.1.2
database_cross_reference: HPO:HP:0031550

Reduced cell surface marker level
type: Class
subclass of: Abnormal flow cytometry test rest
Definition: Reduced level of a protein that is normally present on the cell surface as assessed by flow cytometry.
MCID: MC01400808
PMOID: PMO:00000896
Subclass_of: Abnormal flow cytometry test rest
Tree Number: T3.1.2.1
database_cross_reference: HPO:HP:0031551

Abnormality of blood and blood-forming tissues
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the hematopoietic system.
MCID: MC00296442
PMOID: PMO:00000905
Subclass_of: Phenotypic Abnormality
Synonym: Abnormal;haematological
Synonym: Abnormal;hematological
Synonym: Abnormality of the hematopoietic system
Synonym: Hematological abnormality
Synonym: haematological abnormality
Synonym: hematological abnormality
Tree Number: T3.2
database_cross_reference: HPO:HP:0001871
database_cross_reference: ICPC2P:B86001
database_cross_reference: ICPC2P:B99016

Abnormal bleeding
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.
MCID: MC00520438
PMOID: PMO:00000906
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: BLEEDING ABNORMAL
Synonym: BLEEDING DIATHESIS
Synonym: BLEEDING DISORDER
Synonym: BLEEDING TENDENCY
Synonym: Bleeding Diathesis
Synonym: Bleeding Disorders
Synonym: Bleeding Predisposition
Synonym: Bleeding Tendency
Synonym: Bleeding diathesis
Synonym: Bleeding diathesis (disorder)
Tree Number: T3.2.1
database_cross_reference: CCPSS:0018175
database_cross_reference: CCPSS:0061000
database_cross_reference: CHV:0000047284
database_cross_reference: COSTAR:U000080
database_cross_reference: CST:HEM
database_cross_reference: HPO:HP:0001892
database_cross_reference: ICPC2P:B28001
database_cross_reference: MDR:10005133
database_cross_reference: MDR:10005134
database_cross_reference: MDR:10018967
database_cross_reference: MDR:10055261
database_cross_reference: MEDLINEPLUS:166
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C115221
database_cross_reference: NCI:NMDP/CIBMTR
database_cross_reference: OMIM:MTHU000442
database_cross_reference: OMIM:MTHU012705
database_cross_reference: OMIM:MTHU016228
database_cross_reference: OMIM:MTHU026263
database_cross_reference: RCD:D30..
database_cross_reference: RCD:X76A9
database_cross_reference: SNMI:F-D0730
database_cross_reference: SNOMEDCT_US:123329004
database_cross_reference: SNOMEDCT_US:248250000
database_cross_reference: SNOMEDCT_US:267562007
database_cross_reference: SNOMEDCT_US:64779008
database_cross_reference: SNOMEDCT_US:78596001

Abnormal onset of bleeding
type: Class
subclass of: Abnormal bleeding
MCID: MC01057020
PMOID: PMO:00000907
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.1
database_cross_reference: HPO:HP:0040231

Abnormal umbilical stump bleeding
type: Class
subclass of: Abnormal bleeding
Definition: Abnormal bleeding of the umbilical stump following separation of the cord at approximately 7-10 days after birth.
MCID: MC01001227
PMOID: PMO:00000909
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.2
database_cross_reference: HPO:HP:0011884

Bleeding requiring red cell transfusion
type: Class
subclass of: Abnormal bleeding
Definition: Bleeding sufficiently severe as to require red cell transfusion (WHO Grade 3 or 4).
MCID: MC01397099
PMOID: PMO:00000910
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.3
database_cross_reference: HPO:HP:0011888

Bleeding with minor or no trauma
type: Class
subclass of: Abnormal bleeding
Definition: Significant bleeding or hemorrhage without significant precipitating factor.
MCID: MC01397100
PMOID: PMO:00000911
Subclass_of: Abnormal bleeding
Synonym: Easy bleeding
Tree Number: T3.2.1.4
database_cross_reference: HPO:HP:0011889

Cephalohematoma
type: Class
subclass of: Abnormal bleeding
Definition: Hemorrhage between the skull and periosteum of a newborn resulting from rupture of blood vessels that cross the periosteum.
MCID: MC01397255
PMOID: PMO:00000912
Subclass_of: Abnormal bleeding
Synonym: Cephalohaematoma
Tree Number: T3.2.1.5
database_cross_reference: HPO:HP:0012541

Excessive bleeding after a venipuncture
type: Class
subclass of: Abnormal bleeding
Definition: An abnormal high amount of bleeding following the procedure of taking a blood sample.
MCID: MC01000960
PMOID: PMO:00000913
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.6
database_cross_reference: HPO:HP:0030139

Excessive bleeding from superficial cuts
type: Class
subclass of: Abnormal bleeding
Definition: An abnormally increased degree of bleeding following a superfical injury to the surface of the skin.
MCID: MC01000961
PMOID: PMO:00000914
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.7
database_cross_reference: HPO:HP:0030138

Gingival bleeding
type: Class
subclass of: Abnormal bleeding
Definition: Hemorrhage affecting the gingiva.
MCID: MC00534358
PMOID: PMO:00000915
Subclass_of: Abnormal bleeding
Synonym: Bleeding gums
Synonym: Bleeding of subgingival space
Synonym: Bleeding of subgingival space (disorder)
Synonym: Crevicular bleeding of gum
Synonym: Gingival crevice bleeding
Synonym: Gingival crevicular bleeding
Synonym: Gingival hemorrhage
Synonym: Gingivorrhagia
Tree Number: T3.2.1.8
database_cross_reference: HPO:HP:0000225
database_cross_reference: SNOMEDCT_US:109616007
database_cross_reference: SNOMEDCT_US:86276007

Menorrhagia
type: Class
subclass of: Abnormal bleeding
Definition: Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days.
MCID: MC00008059
PMOID: PMO:00000916
Subclass_of: Abnormal bleeding
Synonym: Abnormally heaving bleeding during menstruation
Synonym: BLEEDING MENSTRUAL HEAVY
Synonym: Bleeding menstrual heavy
Synonym: EXCESSIVE MENSES
Synonym: Excessive menstruation
Synonym: Flooding during periods
Synonym: HYPERMENORRHEA
Synonym: Heavy menstrual period
Synonym: Heavy menstrual period (finding)
Synonym: Heavy period
Tree Number: T3.2.1.9
database_cross_reference: BI:BI00393
database_cross_reference: CHV:0000007949
database_cross_reference: COSTAR:480
database_cross_reference: COSTAR:U000282
database_cross_reference: COSTAR:U000368
database_cross_reference: CSP:1138-6273
database_cross_reference: CST:MENORRHAGIA
database_cross_reference: DXP:U002548
database_cross_reference: HPO:HP:0000132
database_cross_reference: ICD10CM:N92.0
database_cross_reference: ICPC2EENG:X06
database_cross_reference: ICPC2P:X06002
database_cross_reference: ICPC2P:X06005
database_cross_reference: ICPC2P:X06006
database_cross_reference: LCH:U002904
database_cross_reference: LCH_NW:sh85083593
database_cross_reference: MDR:10005123
database_cross_reference: MDR:10015606
database_cross_reference: MDR:10019360
database_cross_reference: MDR:10020672
database_cross_reference: MDR:10020673
database_cross_reference: MDR:10027313
database_cross_reference: MDR:10027322
database_cross_reference: MDR:10027332
database_cross_reference: MDR:10027338
database_cross_reference: MDR:10036867
database_cross_reference: MEDCIN:598
database_cross_reference: MEDCIN:99225
database_cross_reference: MSH:D008595
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:626.2
database_cross_reference: NCI:C26829
database_cross_reference: NCI_CTCAE:E13132
database_cross_reference: NCI_NCI-GLOSS:CDR0000256569
database_cross_reference: NCI_NICHD:C26829
database_cross_reference: NDFRT:N0000001993
database_cross_reference: OMIM:MTHU009110
database_cross_reference: RCD:K5920
database_cross_reference: RCD:XE0eo
database_cross_reference: RCD:Xa4dw
database_cross_reference: RCDAE:XE0eo
database_cross_reference: SNM:F-30170
database_cross_reference: SNMI:F-81170
database_cross_reference: SNOMEDCT_US:123348000
database_cross_reference: SNOMEDCT_US:156038002
database_cross_reference: SNOMEDCT_US:198418008
database_cross_reference: SNOMEDCT_US:289888001
database_cross_reference: SNOMEDCT_US:386692008
database_cross_reference: SNOMEDCT_US:63515003

Persistent bleeding after trauma
type: Class
subclass of: Abnormal bleeding
MCID: MC01400378
PMOID: PMO:00000917
Subclass_of: Abnormal bleeding
Synonym: Excessive bleeding after minor trauma
Synonym: Frequent bleeding with trauma
Synonym: Prolonged bleeding after minor trauma
Tree Number: T3.2.1.10
database_cross_reference: HPO:HP:0001934

Prolonged bleeding following procedure
type: Class
subclass of: Abnormal bleeding
Definition: Prolonged or protracted bleeding following an invasive procedure or intervention.
MCID: MC01400601
PMOID: PMO:00000918
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.11
database_cross_reference: HPO:HP:0011890

Prolonged bleeding time
type: Class
subclass of: Abnormal bleeding
Definition: Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding.
MCID: MC01400602
PMOID: PMO:00000923
Subclass_of: Abnormal bleeding
Synonym: Increased bleeding time
Tree Number: T3.2.1.12
database_cross_reference: HPO:HP:0003010

Abnormal erythrocyte morphology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: Any structural abnormality of erythrocytes (red-blood cells).
MCID: MC00004684
PMOID: PMO:00000924
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: 631-634 ABNORMAL RED BLOOD CELLS
Synonym: ABNORM ERYTHROCYTES
Synonym: ABNORMAL RED BLOOD CELLS
Synonym: Abnormal Erythrocyte
Synonym: Abnormal Erythrocytes
Synonym: Abnormal Red Blood Cell
Synonym: Abnormal erythrocyte
Synonym: Abnormal erythrocyte, NOS
Synonym: Abnormal red blood cell
Synonym: Abnormal red blood cell (cell)
Tree Number: T3.2.2
database_cross_reference: CHV:0000004630
database_cross_reference: HPO:HP:0001877
database_cross_reference: MSH:D004913
database_cross_reference: MTH:U003408
database_cross_reference: NCI:C12522
database_cross_reference: SNMI:M-63100
database_cross_reference: SNOMEDCT_US:12222001
database_cross_reference: SNOMEDCT_US:397019006

Abnormal erythrocyte enzyme activity
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: An altered ability of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered levels of an enzyme.
MCID: MC01395878
PMOID: PMO:00000925
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.1
database_cross_reference: HPO:HP:0030272

Abnormal hematocrit
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: Any deviation from the normal ratio of the volume of red blood cells to the total volume of blood.
MCID: MC01395922
PMOID: PMO:00000929
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.2
database_cross_reference: HPO:HP:0031850

Abnormal hemoglobin
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes.
MCID: MC00006077
PMOID: PMO:00000932
Subclass_of: Abnormal erythrocyte morphology
Synonym: ABNORM HEMOGLOBINS
Synonym: Abnormal Hemoglobins
Synonym: Abnormal haemoglobin
Synonym: Abnormal haemoglobin, NOS
Synonym: Abnormal hemoglobin (substance)
Synonym: Abnormal hemoglobin NOS
Synonym: Abnormal hemoglobin, NOS
Synonym: HEMOGLOBINS ABNORM
Synonym: Hemoglobin, abnormal
Synonym: Hemoglobins, Abnormal
Tree Number: T3.2.2.3
database_cross_reference: CHV:0000005996
database_cross_reference: HPO:HP:0011902
database_cross_reference: ICD10CM:D58.2
database_cross_reference: MSH:D006455
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:282.7
database_cross_reference: NDFRT:N0000170053
database_cross_reference: SNM:F-16600
database_cross_reference: SNM:U000192
database_cross_reference: SNMI:F-D5200
database_cross_reference: SNOMEDCT_US:8257005

Abnormal hemoglobin concentration
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: Any deviation from the normal concentration of hemoglobin in the blood.
MCID: MC01395923
PMOID: PMO:00000944
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.4
database_cross_reference: HPO:HP:0020061

Abnormal mean corpuscular hemoglobin concentration
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: A deviation from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced.
MCID: MC01395991
PMOID: PMO:00000947
Subclass_of: Abnormal erythrocyte morphology
Synonym: Abnormal MCH
Synonym: Abnormal mean corpuscular haemoglobin
Tree Number: T3.2.2.5
database_cross_reference: HPO:HP:0025546

Abnormal mean corpuscular volume
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.
MCID: MC01395992
PMOID: PMO:00000950
Subclass_of: Abnormal erythrocyte morphology
Synonym: Abnormal MCV
Synonym: Abnormal erythrocyte volume
Tree Number: T3.2.2.6
database_cross_reference: HPO:HP:0025065

Abnormal number of erythroid precursors
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.
MCID: MC01001173
PMOID: PMO:00000953
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.7
database_cross_reference: HPO:HP:0012131

Abnormal red blood cell count
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: Any deviation from the normal number of red blood cells per volume in the circulation.
MCID: MC01396101
PMOID: PMO:00000958
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.8
database_cross_reference: HPO:HP:0020058

Abnormality of reticulocytes
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: A reticulocyte abnormality.
MCID: MC01002765
PMOID: PMO:00000961
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.9
database_cross_reference: HPO:HP:0004312

Anemia
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: A reduction in erythrocytes volume or hemoglobin concentration.
MCID: MC00000878
PMOID: PMO:00000964
Subclass_of: Abnormal erythrocyte morphology
Synonym: ANAEMIA
Synonym: ANEMIA
Synonym: Anaemia
Synonym: Anaemia (disorder)
Synonym: Anaemia NOS
Synonym: Anaemia unspecified
Synonym: Anaemia unspecified (disorder)
Synonym: Anaemia, NOS
Synonym: Anaemia, unspecified
Synonym: Anemia (disorder)
Tree Number: T3.2.2.10
database_cross_reference: AOD:0000005870
database_cross_reference: AOD:0000023514
database_cross_reference: BI:BI00026
database_cross_reference: CCPSS:1017210
database_cross_reference: CHV:0000001118
database_cross_reference: COSTAR:051
database_cross_reference: CSP:0427-0313
database_cross_reference: CST:ANEMIA
database_cross_reference: DO:DOID:2355
database_cross_reference: DXP:U000172
database_cross_reference: HPO:HP:0001903
database_cross_reference: ICD10:D64.9
database_cross_reference: ICD10AM:D64.9
database_cross_reference: ICD10AMAE:D64.9
database_cross_reference: ICD10CM:D64.9
database_cross_reference: ICD9CM:285.9
database_cross_reference: ICPC2P:B82005
database_cross_reference: LCH:U000235
database_cross_reference: LCH_NW:sh85004940
database_cross_reference: LNC:LA18969-8
database_cross_reference: LNC:MTHU020823
database_cross_reference: MDR:10002034
database_cross_reference: MDR:10002071
database_cross_reference: MDR:10002082
database_cross_reference: MDR:10002272
database_cross_reference: MDR:10002315
database_cross_reference: MDR:10045627
database_cross_reference: MDR:10055742
database_cross_reference: MEDCIN:30320
database_cross_reference: MEDLINEPLUS:139
database_cross_reference: MSH:D000740
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000161
database_cross_reference: MTH:U000164
database_cross_reference: MTHICD9:285.9
database_cross_reference: NCI:C2869
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_CTCAE:E10010
database_cross_reference: NCI_FDA:1706
database_cross_reference: NCI_NCI-GLOSS:CDR0000045360
database_cross_reference: NCI_NICHD:C2869
database_cross_reference: NDFRT:N0000000384
database_cross_reference: OMIM:MTHU002606
database_cross_reference: PDQ:CDR0000041382
database_cross_reference: PSY:02450
database_cross_reference: RCD:XE140
database_cross_reference: RCD:XM05A
database_cross_reference: RCDAE:XE140
database_cross_reference: RCDAE:XM05A
database_cross_reference: SNM:D-4010
database_cross_reference: SNMI:DC-10010
database_cross_reference: SNOMEDCT_US:154786001
database_cross_reference: SNOMEDCT_US:154812000
database_cross_reference: SNOMEDCT_US:191277004
database_cross_reference: SNOMEDCT_US:267531008
database_cross_reference: SNOMEDCT_US:271737000
database_cross_reference: SNOMEDCT_US:64593003

Anisocytosis
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: Abnormally increased variability in the size of erythrocytes.
MCID: MC01396657
PMOID: PMO:00001009
Subclass_of: Abnormal erythrocyte morphology
Synonym: Unequal size of red blood cells
Tree Number: T3.2.2.11
database_cross_reference: HPO:HP:0011273

Blood group antigen abnormality
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: An abnormality of an erythrocyte cell surface molecule.
MCID: MC01001547
PMOID: PMO:00001010
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.12
database_cross_reference: HPO:HP:0010970

Dysplastic erythropoesis
type: Class
subclass of: Abnormal erythrocyte morphology
MCID: MC01001172
PMOID: PMO:00001012
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.13
database_cross_reference: HPO:HP:0012134

Increased RBC distribution width
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage.
MCID: MC01399181
PMOID: PMO:00001013
Subclass_of: Abnormal erythrocyte morphology
Synonym: Increased red blood cell distribution width
Tree Number: T3.2.2.14
database_cross_reference: HPO:HP:0031965

Poikilocytosis
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: The presence of abnormally shaped erythrocytes.
MCID: MC01400432
PMOID: PMO:00001014
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.15
database_cross_reference: HPO:HP:0004447

Polycythemia
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: Polycythemia is diagnosed if the red blood cell count, the hemoglobin level, and the red blood cell volume all exceed the upper limits of normal.
MCID: MC00010408
PMOID: PMO:00001026
Subclass_of: Abnormal erythrocyte morphology
Synonym: Abnormally shaped erythrocytes
Synonym: Erythrocythaemia
Synonym: Erythrocythemia
Synonym: POLYCYTHAEMIA
Synonym: POLYCYTHEMIA
Synonym: Polycythaemia
Synonym: Polycythaemia NOS
Synonym: Polycythaemia, NOS
Synonym: Polycythemia NOS
Synonym: Polycythemia [Disease/Finding]
Tree Number: T3.2.2.16
database_cross_reference: AOD:0000005927
database_cross_reference: CCPSS:0037624
database_cross_reference: CHV:0000009910
database_cross_reference: COSTAR:594
database_cross_reference: CSP:0427-4465
database_cross_reference: CST:POLYCYTHEMIA
database_cross_reference: DO:DOID:8432
database_cross_reference: DXP:U003191
database_cross_reference: HPO:HP:0001901
database_cross_reference: ICD10CM:D75.1
database_cross_reference: LCH:U003753
database_cross_reference: LCH_NW:sh85104610
database_cross_reference: MDR:10036051
database_cross_reference: MDR:10036055
database_cross_reference: MDR:10036058
database_cross_reference: MEDCIN:363009
database_cross_reference: MSH:D011086
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000162
database_cross_reference: MTH:U000165
database_cross_reference: NCI:C26863
database_cross_reference: NCI_NICHD:C26863
database_cross_reference: NDFRT:N0000002453
database_cross_reference: OMIM:MTHU006480
database_cross_reference: RCD:X20D8
database_cross_reference: RCDAE:X20D8
database_cross_reference: SNM:M-77700
database_cross_reference: SNM:U000386
database_cross_reference: SNMI:DC-38000
database_cross_reference: SNOMEDCT_US:109992005
database_cross_reference: SNOMEDCT_US:127062003
database_cross_reference: SNOMEDCT_US:165401000
database_cross_reference: SNOMEDCT_US:44865000

Reduced erythrocyte 2,3-diphosphoglycerate concentration
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: 2,3-diphosphoglycerate (2,3-DPG) controls the movement of oxygen from red blood cells to tissues. Anemia is usually accompanied by an increased level of 2,3-DPG in order to promote tissue oxygenation. This term refers to an inappropriate low 2,3-DPG concentration in erythrocytes.
MCID: MC01400815
PMOID: PMO:00001029
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.17
database_cross_reference: HPO:HP:0030271

Rouleaux formation
type: Class
subclass of: Abnormal erythrocyte morphology
Definition: Increased amount of stacking of erythrocytes into long chains. Rouleaux (singular: rouleau) is derived from a French word that can refer to a stack of coins put into a cylindircal paper roll. Rouleaux formation is observed with increased serum proteins, particularly fibrinogen and globulins, and represents the cause of increased erythrocte sedimentation rate because rouleaux sediment more readily than isolated red blood cells.
MCID: MC01400986
PMOID: PMO:00001030
Subclass_of: Abnormal erythrocyte morphology
Synonym: Increased rouleaux formation
Tree Number: T3.2.2.18
database_cross_reference: HPO:HP:0031898

Abnormal erythrocyte physiology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: Any functional abnormality of erythrocytes (red-blood cells).
MCID: MC01395879
PMOID: PMO:00001031
Subclass_of: Abnormality of blood and blood-forming tissues
Tree Number: T3.2.3
database_cross_reference: HPO:HP:0020054

Increased hemoglobin oxygen affinity
type: Class
subclass of: Abnormal erythrocyte physiology
Definition: An abnormal increase in the binding affinity of hemoglobin for oxygen.
MCID: MC01399084
PMOID: PMO:00001032
Subclass_of: Abnormal erythrocyte physiology
Synonym: Increased haemoglobin oxygen affinity
Tree Number: T3.2.3.1
database_cross_reference: HPO:HP:0004825

Increased red cell osmotic fragility
type: Class
subclass of: Abnormal erythrocyte physiology
MCID: MC01399186
PMOID: PMO:00001033
Subclass_of: Abnormal erythrocyte physiology
Synonym: Increased erythrocyte osmotic fragility
Synonym: Increased red cell fragility
Tree Number: T3.2.3.2
database_cross_reference: HPO:HP:0005502

Increased red cell osmotic resistance
type: Class
subclass of: Abnormal erythrocyte physiology
MCID: MC01399187
PMOID: PMO:00001034
Subclass_of: Abnormal erythrocyte physiology
Tree Number: T3.2.3.3
database_cross_reference: HPO:HP:0005546

Abnormal myeloid cell morphology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: Any structural anomaly of a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
MCID: MC01396020
PMOID: PMO:00001035
Subclass_of: Abnormality of blood and blood-forming tissues
Tree Number: T3.2.4
database_cross_reference: HPO:HP:0020047

Abnormal erythroid lineage cell morphology
type: Class
subclass of: Abnormal myeloid cell morphology
Definition: An anomaly of erythroid lineage cells, that is, of the erythropoietic cells in the lineage leading to and including erythrocytes.
MCID: MC01395881
PMOID: PMO:00001036
Subclass_of: Abnormal myeloid cell morphology
Synonym: Abnormality of cells of the erythroid lineage
Tree Number: T3.2.4.1
database_cross_reference: HPO:HP:0012130

Abnormal thrombocyte morphology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: An abnormality of platelets.
PMOID: PMO:00001040
Subclass_of: Abnormality of blood and blood-forming tissues
Tree Number: T3.2.5

Abnormal platelet count
type: Class
subclass of: Abnormal thrombocyte morphology
Definition: Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood.
MCID: MC01396056
PMOID: PMO:00001041
Subclass_of: Abnormal thrombocyte morphology
Tree Number: T3.2.5.1
database_cross_reference: HPO:HP:0011873

Abnormal platelet function
type: Class
subclass of: Abnormal thrombocyte morphology
Definition: Any anomaly in the function of thrombocytes.
MCID: MC01396059
PMOID: PMO:00001050
Subclass_of: Abnormal thrombocyte morphology
Tree Number: T3.2.5.2
database_cross_reference: HPO:HP:0011869

Abnormal platelet morphology
type: Class
subclass of: Abnormal thrombocyte morphology
Definition: An anomaly in platelet form, ultrastructure, or intracellular organelles.
MCID: MC01396062
PMOID: PMO:00001084
Subclass_of: Abnormal thrombocyte morphology
Synonym: Abnormal shape of platelets
Tree Number: T3.2.5.3
database_cross_reference: HPO:HP:0011875

Abnormal platelet volume
type: Class
subclass of: Abnormal thrombocyte morphology
Definition: Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers.
MCID: MC01001231
PMOID: PMO:00001098
Subclass_of: Abnormal thrombocyte morphology
Tree Number: T3.2.5.4
database_cross_reference: HPO:HP:0011876

Abnormal thrombosis
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis).
MCID: MC01003008
PMOID: PMO:00001103
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: Abnormal blood clot
Tree Number: T3.2.6
database_cross_reference: HPO:HP:0001977

Arterial thrombosis
type: Class
subclass of: Abnormal thrombosis
Definition: The formation of a blood clot inside an artery.
MCID: MC00058272
PMOID: PMO:00001104
Subclass_of: Abnormal thrombosis
Synonym: ARTERIAL THROMBOSIS
Synonym: Arterial Thrombosis
Synonym: Arterial thrombosis (disorder)
Synonym: Arterial thrombosis NOS
Synonym: Arterial thrombosis, NOS, of unspecified artery
Synonym: Blood clot in artery
Synonym: THROMBOSIS ARTERIAL
Synonym: Thrombosis - arterial
Synonym: Thrombosis arterial
Synonym: Thrombosis;arterial
Tree Number: T3.2.6.1
database_cross_reference: CCPSS:0033511
database_cross_reference: CHV:0000017111
database_cross_reference: CST:PATHTROMBART
database_cross_reference: CST:THROM ART
database_cross_reference: HPO:HP:0004420
database_cross_reference: ICPC2P:K92014
database_cross_reference: MDR:10003178
database_cross_reference: MDR:10003181
database_cross_reference: MDR:10043611
database_cross_reference: MEDCIN:236660
database_cross_reference: NCI:C98826
database_cross_reference: NCI_NICHD:C98826
database_cross_reference: OMIM:MTHU015923
database_cross_reference: RCD:X203s
database_cross_reference: SNMI:D3-81500
database_cross_reference: SNOMEDCT_US:195315009
database_cross_reference: SNOMEDCT_US:65198009

Disseminated intravascular coagulation
type: Class
subclass of: Abnormal thrombosis
Definition: Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels.
MCID: MC00004058
PMOID: PMO:00001105
Subclass_of: Abnormal thrombosis
Synonym: COAG DISSEM INTRAVASC
Synonym: CONSUMPTION COAGULOPATHY
Synonym: Coagulation (DIC), Disseminated Intravascular
Synonym: Coagulation, Disseminated Intravascular
Synonym: Coagulation, Intravascular Disseminated
Synonym: Coagulations, Disseminated Intravascular
Synonym: Coagulations, Intravascular Disseminated
Synonym: Coagulopathies, Consumption
Synonym: Coagulopathy, Consumption
Synonym: Consumption Coagulopathies
Tree Number: T3.2.6.2
database_cross_reference: CCPSS:1013555
database_cross_reference: CHV:0000004034
database_cross_reference: CSP:0438-8377
database_cross_reference: CST:DIC
database_cross_reference: CST:PATHDIC
database_cross_reference: DO:DOID:0060538
database_cross_reference: DO:DOID:11247
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000486
database_cross_reference: HPO:HP:0005521
database_cross_reference: ICD10:D65
database_cross_reference: ICD10AM:D65
database_cross_reference: ICD10CM:D65
database_cross_reference: ICD9CM:286.6
database_cross_reference: ICPC2P:B83017
database_cross_reference: LCH:U001430
database_cross_reference: LCH_NW:sh85038487
database_cross_reference: MDR:10010785
database_cross_reference: MDR:10010786
database_cross_reference: MDR:10012126
database_cross_reference: MDR:10012769
database_cross_reference: MDR:10013429
database_cross_reference: MDR:10013441
database_cross_reference: MDR:10013442
database_cross_reference: MEDCIN:30388
database_cross_reference: MEDCIN:96948
database_cross_reference: MSH:D004211
database_cross_reference: MTH:U001871
database_cross_reference: MTHICD9:286.6
database_cross_reference: NCI:C2992
database_cross_reference: NCI_FDA:1813
database_cross_reference: NCI_NICHD:C2992
database_cross_reference: NDFRT:N0000000985
database_cross_reference: OMIM:MTHU021343
database_cross_reference: RCD:D306.
database_cross_reference: SNM:D-4411
database_cross_reference: SNMI:DC-60020
database_cross_reference: SNOMEDCT_US:267563002
database_cross_reference: SNOMEDCT_US:67406007

Peripheral thrombosis
type: Class
subclass of: Abnormal thrombosis
MCID: MC00610168
PMOID: PMO:00001108
Subclass_of: Abnormal thrombosis
Synonym: Peripheral blood clot
Tree Number: T3.2.6.3
database_cross_reference: HPO:HP:0002641
database_cross_reference: OMIM:MTHU010059

Thromboembolism
type: Class
subclass of: Abnormal thrombosis
Definition: The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site.
MCID: MC00012786
PMOID: PMO:00001109
Subclass_of: Abnormal thrombosis
Synonym: Embolism and thrombosis of unspecified site
Synonym: Other venous embolism and thrombosis of unspecified site
Synonym: THROMBOEMBOLIC DISEASE
Synonym: THROMBOEMBOLISM
Synonym: Thromboembolic Event
Synonym: Thromboembolic disease
Synonym: Thromboembolic disorder
Synonym: Thromboembolic disorder (disorder)
Synonym: Thromboembolic event
Synonym: Thromboembolic events
Tree Number: T3.2.6.4
database_cross_reference: AOD:0000005941
database_cross_reference: CCPSS:0036096
database_cross_reference: CHV:0000012222
database_cross_reference: CHV:0000050545
database_cross_reference: CSP:0571-3989
database_cross_reference: CST:EMB
database_cross_reference: HPO:HP:0001907
database_cross_reference: ICD9CM:453.9
database_cross_reference: LCH:U004669
database_cross_reference: LCH_NW:sh85135071
database_cross_reference: MDR:10014511
database_cross_reference: MDR:10043565
database_cross_reference: MDR:10043566
database_cross_reference: MDR:10043567
database_cross_reference: MEDCIN:95291
database_cross_reference: MSH:D013923
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:453.9
database_cross_reference: NCI:C28195
database_cross_reference: NCI_CTCAE:E13825
database_cross_reference: NCI_FDA:2654
database_cross_reference: NCI_NICHD:C28195
database_cross_reference: NDFRT:N0000002934
database_cross_reference: OMIM:MTHU008847
database_cross_reference: OMIM:MTHU010071
database_cross_reference: PDQ:CDR0000037886
database_cross_reference: RCD:XaBUu
database_cross_reference: SNM:M-35300
database_cross_reference: SNMI:M-35310
database_cross_reference: SNOMEDCT_US:134356002
database_cross_reference: SNOMEDCT_US:13713005
database_cross_reference: SNOMEDCT_US:371039008

Venous thrombosis
type: Class
subclass of: Abnormal thrombosis
Definition: Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow.
MCID: MC00013520
PMOID: PMO:00001112
Subclass_of: Abnormal thrombosis
Synonym: Blood clot in vein
Synonym: PHLEBOTHROMBOSIS
Synonym: Phlebothromboses
Synonym: Phlebothrombosis
Synonym: Phlebothrombosis (disorder)
Synonym: Phlebothrombosis, NOS
Synonym: THROMBOSIS VENOUS
Synonym: Thromboses, Venous
Synonym: Thrombosis (vein) NOS
Synonym: Thrombosis of vein NOS
Tree Number: T3.2.6.5
database_cross_reference: CCPSS:0008959
database_cross_reference: CHV:0000012947
database_cross_reference: CHV:0000037596
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0571-8485
database_cross_reference: CST:PATHTHROMBVEN
database_cross_reference: CST:THROMBOPHLEB
database_cross_reference: DXP:U004370
database_cross_reference: HPO:HP:0004936
database_cross_reference: ICD10CM:I82.90
database_cross_reference: ICPC2P:K94008
database_cross_reference: MDR:10034904
database_cross_reference: MDR:10043640
database_cross_reference: MDR:10047249
database_cross_reference: MDR:10047253
database_cross_reference: MEDCIN:38214
database_cross_reference: MEDLINEPLUS:1683
database_cross_reference: MEDLINEPLUS:6076
database_cross_reference: MSH:D020246
database_cross_reference: MTH:U002301
database_cross_reference: MTHICD9:453.9
database_cross_reference: NCI:C99107
database_cross_reference: NCI_NICHD:C99107
database_cross_reference: NDFRT:N0000004074
database_cross_reference: OMIM:188050
database_cross_reference: OMIM:MTHU002871
database_cross_reference: RCD:XE0Vb
database_cross_reference: RCD:Xa0l8
database_cross_reference: SNM:M-35190
database_cross_reference: SNMI:D3-87004
database_cross_reference: SNMI:D3-87500
database_cross_reference: SNOMEDCT_US:111293003
database_cross_reference: SNOMEDCT_US:155458001
database_cross_reference: SNOMEDCT_US:18266009
database_cross_reference: SNOMEDCT_US:195442006
database_cross_reference: SNOMEDCT_US:266269008

Abnormality of bone marrow cell morphology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: An anomaly of the form or number of cells in the bone marrow.
MCID: MC01000235
PMOID: PMO:00001123
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: Anomaly of the bone marrow cells
Tree Number: T3.2.7
database_cross_reference: HPO:HP:0005561

Abnormal granulocytopoietic cell morphology
type: Class
subclass of: Abnormality of bone marrow cell morphology
Definition: An anomaly of cells involved in the formation of a granulocytes, that is, of the granulocytopoietic cell.
PMOID: PMO:00001124
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.1

Abnormal megakaryocyte morphology
type: Class
subclass of: Abnormality of bone marrow cell morphology
Definition: Any structural anomaly of megakaryocytes. Mature blood platelets are released from the cytoplasm of megakaryocytes, which are bone-marrow resident cells.
PMOID: PMO:00001130
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.2

Abnormality of bone marrow stromal cells
type: Class
subclass of: Abnormality of bone marrow cell morphology
MCID: MC01001174
PMOID: PMO:00001138
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.3
database_cross_reference: HPO:HP:0012129

Abnormality of multiple cell lineages in the bone marrow
type: Class
subclass of: Abnormality of bone marrow cell morphology
MCID: MC01001164
PMOID: PMO:00001139
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.4
database_cross_reference: HPO:HP:0012145

Reduced bone-marrow pro-B cell count
type: Class
subclass of: Abnormality of bone marrow cell morphology
Definition: A reduction in the numbers of pro-B cells (defined by coexpression of CD34 and CD19). Earlier B-cell precursors are defined by expressing surface CD34 and cytoplasmic TdT in the absence of CD19.
MCID: MC01400797
PMOID: PMO:00001146
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.5
database_cross_reference: HPO:HP:0020048

Abnormality of coagulation
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: An abnormality of the process of blood coagulation. That is, altered ability or inability of the blood to clot.
PMOID: PMO:00001147
Subclass_of: Abnormality of blood and blood-forming tissues
Tree Number: T3.2.8

Abnormality of fibrinolysis
type: Class
subclass of: Abnormality of coagulation
Definition: Clincial phenotype characterized by delayed bleeding accelerated break down of blood clot (fibrinolysis)
MCID: MC01396284
PMOID: PMO:00001148
Subclass_of: Abnormality of coagulation
Synonym: Abnormality of the fibrinolytic system
Tree Number: T3.2.8.1
database_cross_reference: HPO:HP:0040224

Abnormality of the coagulation cascade
type: Class
subclass of: Abnormality of coagulation
Definition: An abnormality of the coagulation cascade, which is comprised of the contact activation pathway (also known as the intrinsic pathway) and the tissue factor pathway (also known as the extrinsic pathway) as well as cofactors and regulators.
MCID: MC00001825
PMOID: PMO:00001154
Subclass_of: Abnormality of coagulation
Synonym: (Coagulation defects) or (bleeding disorders)
Synonym: (Coagulation defects) or (bleeding disorders) (disorder)
Synonym: Abnormal;coagulation
Synonym: BLOOD COAG DIS
Synonym: BLOOD COAGULATION DEFECT
Synonym: BLOOD COAGULATION DISORDER
Synonym: Blood Coagulation Disorder
Synonym: Blood Coagulation Disorders
Synonym: Blood Coagulation Disorders [Disease/Finding]
Synonym: Blood Coagulation Disorders, Diseases and Syndromes
Tree Number: T3.2.8.2
database_cross_reference: AOD:0000005928
database_cross_reference: AOD:0000005929
database_cross_reference: CCPSS:0027739
database_cross_reference: CHV:0000001990
database_cross_reference: COSTAR:188
database_cross_reference: COSTAR:U000185
database_cross_reference: CSP:0438-1873
database_cross_reference: CST:COAGUL DIS
database_cross_reference: CST:HAL/COAG
database_cross_reference: DO:DOID:1247
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000386
database_cross_reference: HPO:HP:0001928
database_cross_reference: HPO:HP:0003256
database_cross_reference: ICD10:D68.9
database_cross_reference: ICD10AM:D68.9
database_cross_reference: ICD10CM:D68.9
database_cross_reference: ICD9CM:286
database_cross_reference: ICPC2P:B83001
database_cross_reference: LCH:U006363
database_cross_reference: LCH_NW:sh85014937
database_cross_reference: MDR:10009727
database_cross_reference: MDR:10009729
database_cross_reference: MDR:10009731
database_cross_reference: MDR:10009734
database_cross_reference: MDR:10009802
database_cross_reference: MDR:10012116
database_cross_reference: MDR:10013206
database_cross_reference: MDR:10048498
database_cross_reference: MDR:10053567
database_cross_reference: MDR:10064732
database_cross_reference: MEDCIN:35838
database_cross_reference: MEDLINEPLUS:166
database_cross_reference: MEDLINEPLUS:3115
database_cross_reference: MSH:D001778
database_cross_reference: MTH:188
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:286.9
database_cross_reference: NCI:C2902
database_cross_reference: NCI_FDA:1779
database_cross_reference: NCI_NICHD:C2902
database_cross_reference: NDFRT:N0000000575
database_cross_reference: OMIM:MTHU008649
database_cross_reference: OMIM:MTHU033936
database_cross_reference: RCD:D30..
database_cross_reference: RCD:D30z.
database_cross_reference: SNM:D-4400
database_cross_reference: SNM:F-54302
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DC-60000
database_cross_reference: SNOMEDCT_US:127073005
database_cross_reference: SNOMEDCT_US:154815003
database_cross_reference: SNOMEDCT_US:191303002
database_cross_reference: SNOMEDCT_US:267562007
database_cross_reference: SNOMEDCT_US:362970003
database_cross_reference: SNOMEDCT_US:64779008

Hypercoagulability
type: Class
subclass of: Abnormality of coagulation
Definition: An abnormality of coagulation associated with an increased risk of thrombosis.
MCID: MC00140330
PMOID: PMO:00001211
Subclass_of: Abnormality of coagulation
Synonym: Blood hyperviscosity
Synonym: Excessive Blood Clotting
Synonym: HYPERCOAGULABLE STATE
Synonym: HYPERCOAGULATION
Synonym: Hypercoaguability
Synonym: Hypercoagulabilities
Synonym: Hypercoagulability State
Synonym: Hypercoagulability state
Synonym: Hypercoagulability state (finding)
Synonym: Hypercoagulability state, NOS
Tree Number: T3.2.8.3
database_cross_reference: CCPSS:0026526
database_cross_reference: CHV:0000032391
database_cross_reference: CHV:0000038554
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:COAGUL DIS
database_cross_reference: DO:DOID:2452
database_cross_reference: HPO:HP:0100724
database_cross_reference: ICD10CM:D68.59
database_cross_reference: MDR:10020608
database_cross_reference: MDR:10057396
database_cross_reference: MDR:10075816
database_cross_reference: MEDCIN:313610
database_cross_reference: MEDLINEPLUS:6076
database_cross_reference: MSH:D019851
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84479
database_cross_reference: NCI_NICHD:C84479
database_cross_reference: NDFRT:N0000003961
database_cross_reference: OMIM:MTHU054815
database_cross_reference: RCD:X20Ej
database_cross_reference: SNM:F-54360
database_cross_reference: SNMI:F-D0750
database_cross_reference: SNOMEDCT_US:191302007
database_cross_reference: SNOMEDCT_US:234467004
database_cross_reference: SNOMEDCT_US:76612001

Prolonged partial thromboplastin time
type: Class
subclass of: Abnormality of coagulation
Definition: Increased time to coagulation in the partial thromboplastin time (PTT) test, a measure of the intrinsic and common coagulation pathways. Phospholipid, and activator, and calcium are mixed into an anticoagulated plasma sample, and the time is measured until a thrombus forms.
MCID: MC01400606
PMOID: PMO:00001212
Subclass_of: Abnormality of coagulation
Synonym: Abnormal partial thromboplastin time
Synonym: Delayed thromboplastin generation
Synonym: Partial thromboplastin time prolonged
Synonym: Prolonged activated partial thromboplastin time
Tree Number: T3.2.8.4
database_cross_reference: HPO:HP:0003645

Prolonged whole-blood clotting time
type: Class
subclass of: Abnormality of coagulation
Definition: An abnormal prolongation (delay) in the time required by whole blood to produce a visible clot.
MCID: MC01400613
PMOID: PMO:00001213
Subclass_of: Abnormality of coagulation
Synonym: Prolonged clotting time
Tree Number: T3.2.8.5
database_cross_reference: HPO:HP:0005542

Extramedullary hematopoiesis
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms.
MCID: MC00006032
PMOID: PMO:00001214
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: Extramedullary Hematopoieses
Synonym: Extramedullary Hematopoiesis
Synonym: Extramedullary Hematopoiesis Function
Synonym: Hematopoieses, Extramedullary
Synonym: Hematopoiesis, Extramedullary
Synonym: extramedullary haematopoiesis
Synonym: extramedullary hematopoiesis
Tree Number: T3.2.9
database_cross_reference: CHV:0000005959
database_cross_reference: MSH:D006411
database_cross_reference: MTH:NOCODE

Hematological neoplasm
type: Class
subclass of: Abnormality of blood and blood-forming tissues
Definition: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue).
MCID: MC00133359
PMOID: PMO:00001215
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: Blood cancer
Synonym: Blood tumor
Synonym: Carcinoma;blood
Synonym: Carcinoma;bone;marrow
Synonym: HEMATOL MALIGNANCIES
Synonym: HEMATOL MALIGNANCY
Synonym: HEMATOL NEOPL
Synonym: Haematologic malignancy
Synonym: Haematologic neoplasm
Synonym: Haematological malignancy
Tree Number: T3.2.10
database_cross_reference: CHV:0000031196
database_cross_reference: CHV:0000031810
database_cross_reference: CHV:0000049723
database_cross_reference: CSP:2004-0139
database_cross_reference: HPO:HP:0001909
database_cross_reference: HPO:HP:0004377
database_cross_reference: ICPC2P:B74010
database_cross_reference: ICPC2P:B74011
database_cross_reference: MDR:10066476
database_cross_reference: MDR:10066481
database_cross_reference: MSH:D019337
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C27134
database_cross_reference: NCI_NCI-GLOSS:CDR0000045708
database_cross_reference: NDFRT:N0000003918
database_cross_reference: PDQ:CDR0000039800
database_cross_reference: SNOMEDCT_US:127221002
database_cross_reference: SNOMEDCT_US:129154003
database_cross_reference: SNOMEDCT_US:269475001

Leukemia
type: Class
subclass of: Hematological neoplasm
Definition: A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.
MCID: MC00007469
PMOID: PMO:00001216
Subclass_of: Hematological neoplasm
Synonym: -- Leukemia
Synonym: 980 LEUKEMIAS, NOS
Synonym: 980-994 LEUKEMIAS
Synonym: Aleukaemic leukaemia [obs]
Synonym: Aleukemic leukemia [obs]
Synonym: Blood (Leukemia)
Synonym: Chronic leukaemia [obs]
Synonym: Chronic leukemia [obs]
Synonym: LEUKAEMIA
Synonym: LEUKEMIA
Tree Number: T3.2.10.1
database_cross_reference: AOD:0000004617
database_cross_reference: BI:BI00316
database_cross_reference: CCPSS:0051957
database_cross_reference: CHV:0000007330
database_cross_reference: CHV:0000049549
database_cross_reference: COSTAR:U000412
database_cross_reference: CSP:2004-1566
database_cross_reference: CST:LEUKEMIA
database_cross_reference: DO:DOID:1240
database_cross_reference: DXP:U002348
database_cross_reference: HPO:HP:0001909
database_cross_reference: ICD10:C95
database_cross_reference: ICD10:C95.9
database_cross_reference: ICD10AM:C95
database_cross_reference: ICD10AM:C95.9
database_cross_reference: ICD10AM:C95.90
database_cross_reference: ICD10AM:M9800/3
database_cross_reference: ICD10AMAE:C95
database_cross_reference: ICD10AMAE:C95.9
database_cross_reference: ICD10AMAE:C95.90
database_cross_reference: ICD10AMAE:M9800/3
database_cross_reference: ICD10CM:C95
database_cross_reference: ICD10CM:C95.9
database_cross_reference: ICD10CM:C95.90
database_cross_reference: ICD9CM:208
database_cross_reference: ICD9CM:208.9
database_cross_reference: ICPC2EENG:B73
database_cross_reference: ICPC2P:B73001
database_cross_reference: LCH:U002665
database_cross_reference: LCH_NW:sh85076285
database_cross_reference: LNC:LA10545-4
database_cross_reference: MDR:10024288
database_cross_reference: MDR:10024312
database_cross_reference: MDR:10024314
database_cross_reference: MDR:10024323
database_cross_reference: MDR:10024324
database_cross_reference: MDR:10024329
database_cross_reference: MDR:10024351
database_cross_reference: MDR:10024352
database_cross_reference: MDR:10045991
database_cross_reference: MDR:10045992
database_cross_reference: MDR:10045994
database_cross_reference: MDR:10060430
database_cross_reference: MDR:10060500
database_cross_reference: MEDCIN:31470
database_cross_reference: MEDLINEPLUS:5620
database_cross_reference: MSH:D007938
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:208.9
database_cross_reference: NCI:C3161
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3161
database_cross_reference: NCI_CTEP-SDC:10024312
database_cross_reference: NCI_NCI-GLOSS:CDR0000045343
database_cross_reference: NCI_NICHD:C3161
database_cross_reference: NDFRT:N0000001815
database_cross_reference: OMIM:MTHU008966
database_cross_reference: PDQ:CDR0000041186
database_cross_reference: PSY:28260
database_cross_reference: RCD:B68..
database_cross_reference: RCD:B68z.
database_cross_reference: RCD:BBr..
database_cross_reference: RCD:BBr0.

Lymphoma
type: Class
subclass of: Hematological neoplasm
Definition: A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells.
MCID: MC00007756
PMOID: PMO:00001238
Subclass_of: Hematological neoplasm
Synonym: Germinoblastic Sarcoma
Synonym: Germinoblastic Sarcomas
Synonym: Germinoblastic sarcoma
Synonym: Germinoblastoma
Synonym: Germinoblastomas
Synonym: LYMPHOMA
Synonym: LYMPHOMA MALIGNANT
Synonym: LYMPHOMA, MALIGNANT
Synonym: Lymphoma (Hodgkin and Non-Hodgkin)
Synonym: Lymphoma (Hodgkin's and Non-Hodgkin's)
Tree Number: T3.2.10.2
database_cross_reference: AOD:0000004624
database_cross_reference: BI:BI00323
database_cross_reference: CCPSS:1017994
database_cross_reference: CHV:0000007617
database_cross_reference: COSTAR:462
database_cross_reference: CSP:2004-6589
database_cross_reference: CST:LYMPHOMA LIKE REACT
database_cross_reference: DO:DOID:0060058
database_cross_reference: DXP:U002475
database_cross_reference: HPO:HP:0002665
database_cross_reference: ICD10AM:M9590/3
database_cross_reference: ICD10CM:C85.9
database_cross_reference: ICPC2P:B72002
database_cross_reference: LCH:U002766
database_cross_reference: LCH_NW:sh85079154
database_cross_reference: LNC:LA15685-3
database_cross_reference: MDR:10025310
database_cross_reference: MDR:10025315
database_cross_reference: MDR:10025316
database_cross_reference: MDR:10025632
database_cross_reference: MDR:10025633
database_cross_reference: MEDCIN:36081
database_cross_reference: MEDLINEPLUS:117
database_cross_reference: MSH:D008223
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:200.8
database_cross_reference: MTHICD9:202.8
database_cross_reference: NCI:C3208
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3208
database_cross_reference: NCI_CTEP-SDC:10025316
database_cross_reference: NCI_FDA:3263
database_cross_reference: NCI_NCI-GLOSS:CDR0000045368
database_cross_reference: NCI_NICHD:C3208
database_cross_reference: NDFRT:N0000001905
database_cross_reference: OMIM:MTHU007429
database_cross_reference: PDQ:CDR0000041429
database_cross_reference: RCD:B62y.
database_cross_reference: RCD:B62y0
database_cross_reference: RCD:BBg1.
database_cross_reference: RCD:X77q5
database_cross_reference: RCD:Xa99k
database_cross_reference: RCDSY:BBg1.
database_cross_reference: SNM:M-9590/3
database_cross_reference: SNM:M-9613/3
database_cross_reference: SNM:M-9632/3
database_cross_reference: SNMI:M-95903
database_cross_reference: SNOMEDCT_US:115244002
database_cross_reference: SNOMEDCT_US:118600007
database_cross_reference: SNOMEDCT_US:134218000
database_cross_reference: SNOMEDCT_US:188676008
database_cross_reference: SNOMEDCT_US:188694002
database_cross_reference: SNOMEDCT_US:188695001
database_cross_reference: SNOMEDCT_US:188704004
database_cross_reference: SNOMEDCT_US:189959002
database_cross_reference: SNOMEDCT_US:189965002
database_cross_reference: SNOMEDCT_US:21964009
database_cross_reference: SNOMEDCT_US:269627002
database_cross_reference: SNOMEDCT_VET:118600007

Lymphoproliferative disorder
type: Class
subclass of: Hematological neoplasm
MCID: MC00007765
PMOID: PMO:00001250
Subclass_of: Hematological neoplasm
Synonym: Disorder, Lymphoproliferative
Synonym: Disorders, Lymphoproliferative
Synonym: Duncan syndrome
Synonym: Duncan's syndrome
Synonym: LYMPHOPROLIFERATIVE DIS
Synonym: Lymphoproliferative Disorder
Synonym: Lymphoproliferative Disorders
Synonym: Lymphoproliferative Disorders [Disease/Finding]
Synonym: Lymphoproliferative disease
Synonym: Lymphoproliferative disease (morphologic abnormality)
Tree Number: T3.2.10.3
database_cross_reference: CHV:0000007624
database_cross_reference: DO:DOID:619
database_cross_reference: HPO:HP:0005523
database_cross_reference: ICD10AM:M9970/1
database_cross_reference: ICD10CM:D47.9
database_cross_reference: LCH:U002767
database_cross_reference: LCH_NW:sh85079155
database_cross_reference: MDR:10025351
database_cross_reference: MDR:10061232
database_cross_reference: MDR:10068350
database_cross_reference: MEDCIN:312073
database_cross_reference: MSH:D008232
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C9308
database_cross_reference: NCI_NCI-GLOSS:CDR0000045767
database_cross_reference: NDFRT:N0000001914
database_cross_reference: OMIM:MTHU038984
database_cross_reference: RCD:X20Ik
database_cross_reference: RCD:Xa0QI
database_cross_reference: SNM:M-9969/1
database_cross_reference: SNMI:M-99701
database_cross_reference: SNOMEDCT_US:277466009
database_cross_reference: SNOMEDCT_US:414629003
database_cross_reference: SNOMEDCT_US:77121009
database_cross_reference: SNOMEDCT_US:84631004

Malignant eosinophil proliferation
type: Class
subclass of: Hematological neoplasm
MCID: MC00610689
PMOID: PMO:00001251
Subclass_of: Hematological neoplasm
Synonym: EMP
Synonym: EOSINOPHILS, MALIGNANT PROLIFERATION OF
Synonym: Eosinophils, Malignant Proliferation of
Synonym: MPE
Synonym: MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
Synonym: Myeloproliferative Disorder, Chronic, with Eosinophilia
Tree Number: T3.2.10.4
database_cross_reference: HPO:HP:0006782
database_cross_reference: MSH:C565054
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:131440

Multiple myeloma
type: Class
subclass of: Hematological neoplasm
Definition: A malignant plasma cell tumor growing within soft tissue or within the skeleton.
MCID: MC00008470
PMOID: PMO:00001252
Subclass_of: Hematological neoplasm
Synonym: Cell Myeloma, Plasma
Synonym: Cell Myelomas, Plasma
Synonym: Disease, Kahler
Synonym: KAHLER DISEASE
Synonym: KAHLER-BOZZOLO DISEASE
Synonym: Kahler Disease
Synonym: Kahler disease
Synonym: Kahler's disease
Synonym: MULTIPLE MYELOMA
Synonym: MULTIPLE MYELOMA MYELOMATOSIS
Tree Number: T3.2.10.5
database_cross_reference: AOD:0000004636
database_cross_reference: CCPSS:0046024
database_cross_reference: CHV:0000008325
database_cross_reference: COSTAR:496
database_cross_reference: CSP:2004-0850
database_cross_reference: CST:MYELOMA
database_cross_reference: DO:DOID:9538
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001237
database_cross_reference: HPO:HP:0006775
database_cross_reference: ICD10:C90.0
database_cross_reference: ICD10AM:C90.0
database_cross_reference: ICD10AM:M9732/3
database_cross_reference: ICD10CM:C90.0
database_cross_reference: ICD10CM:C90.00
database_cross_reference: ICD9CM:203.0
database_cross_reference: ICPC2P:B74015
database_cross_reference: LCH:U003053
database_cross_reference: LCH_NW:sh85088367
database_cross_reference: MDR:10028228
database_cross_reference: MDR:10028232
database_cross_reference: MDR:10028566
database_cross_reference: MDR:10028568
database_cross_reference: MDR:10028569
database_cross_reference: MDR:10034613
database_cross_reference: MDR:10035226
database_cross_reference: MDR:10074470
database_cross_reference: MEDCIN:31705
database_cross_reference: MEDLINEPLUS:332
database_cross_reference: MSH:D009101
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:203.0
database_cross_reference: NCI:C3242
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3242
database_cross_reference: NCI_CTEP-SDC:10028566
database_cross_reference: NCI_NCI-GLOSS:CDR0000045793
database_cross_reference: NCI_NCI-GLOSS:CDR0000045795
database_cross_reference: NCI_NCI-GLOSS:CDR0000411381
database_cross_reference: NCI_NCI-GLOSS:CDR0000411383
database_cross_reference: NCI_NCI-GLOSS:CDR0000411384
database_cross_reference: NDFRT:N0000002050
database_cross_reference: OMIM:254500
database_cross_reference: OMIM:MTHU028344
database_cross_reference: PDQ:CDR0000037974
database_cross_reference: PDQ:CDR0000040068
database_cross_reference: PDQ:CDR0000042947
database_cross_reference: RCD:B630.
database_cross_reference: RCD:BBn0.
database_cross_reference: SNM:M-9730/3
database_cross_reference: SNMI:M-97323
database_cross_reference: SNOMEDCT_US:109989006
database_cross_reference: SNOMEDCT_US:154585004
database_cross_reference: SNOMEDCT_US:55921005
database_cross_reference: SNOMEDCT_US:94705007
database_cross_reference: SNOMEDCT_VET:109989006

Myelodysplasia
type: Class
subclass of: Hematological neoplasm
Definition: Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.
MCID: MC00896397
PMOID: PMO:00001253
Subclass_of: Hematological neoplasm
Synonym: 998 MYELODYSPLASTIC SYNDROME
Synonym: Dysmyelopoietic Syndrome
Synonym: Dysmyelopoietic Syndromes
Synonym: Dysmyelopoietic syndrome
Synonym: Hematopoeitic - Myelodysplastic Syndrome (MDS)
Synonym: MDS
Synonym: MDS - Myelodysplastic syndrome
Synonym: MYELODYSPLASTIC SYNDROME
Synonym: MYELODYSPLASTIC SYNDROME, SUSCEPTIBILITY TO
Synonym: Myelodysplasia (disorder)
Tree Number: T3.2.10.6
database_cross_reference: CCPSS:0045936
database_cross_reference: CHV:0000008407
database_cross_reference: CHV:0000010081
database_cross_reference: COSTAR:U000455
database_cross_reference: DXP:U001579
database_cross_reference: HPO:HP:0002863
database_cross_reference: ICD10:D46
database_cross_reference: ICD10:D46.9
database_cross_reference: ICD10AM:D46
database_cross_reference: ICD10AM:D46.9
database_cross_reference: ICD10AM:M9989/1
database_cross_reference: ICD10CM:D46
database_cross_reference: ICD10CM:D46.9
database_cross_reference: ICD9CM:238.75
database_cross_reference: ICPC2P:B75008
database_cross_reference: LCH:U003813
database_cross_reference: LCH_NW:sh85106315
database_cross_reference: LCH_NW:sh88001636
database_cross_reference: MDR:10028533
database_cross_reference: MDR:10028534
database_cross_reference: MDR:10028536
database_cross_reference: MDR:10028548
database_cross_reference: MDR:10036587
database_cross_reference: MDR:10054577
database_cross_reference: MEDCIN:35938
database_cross_reference: MEDCIN:98952
database_cross_reference: MEDLINEPLUS:5550
database_cross_reference: MSH:D009190
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3247
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CTCAE:E12552
database_cross_reference: NCI_CTEP-SDC:10028534
database_cross_reference: NCI_NCI-GLOSS:CDR0000045266
database_cross_reference: NCI_NCI-GLOSS:CDR0000045480
database_cross_reference: NCI_NCI-GLOSS:CDR0000045953
database_cross_reference: NCI_NCI-GLOSS:CDR0000046583
database_cross_reference: NCI_NICHD:C3247
database_cross_reference: NDFRT:N0000002079
database_cross_reference: OMIM:614286
database_cross_reference: OMIM:MTHU002415
database_cross_reference: OMIM:MTHU024110
database_cross_reference: PDQ:CDR0000039817
database_cross_reference: RCD:BBv..
database_cross_reference: RCD:ByuHD
database_cross_reference: RCD:Xa0SY
database_cross_reference: RCDSY:BBv..
database_cross_reference: RCDSY:ByuHD
database_cross_reference: SNM:D-4005
database_cross_reference: SNMI:M-99800
database_cross_reference: SNMI:M-99891
database_cross_reference: SNOMEDCT_US:109995007
database_cross_reference: SNOMEDCT_US:109999001
database_cross_reference: SNOMEDCT_US:128623006
database_cross_reference: SNOMEDCT_US:188736006
database_cross_reference: SNOMEDCT_US:189508006
database_cross_reference: SNOMEDCT_US:189515003
database_cross_reference: SNOMEDCT_US:190229005
database_cross_reference: SNOMEDCT_US:25707000
database_cross_reference: SNOMEDCT_US:393565000
database_cross_reference: SNOMEDCT_US:4227006

Plasmacytoma
type: Class
subclass of: Hematological neoplasm
Definition: A discrete mass of neoplastic monoclonal plasma cells either in the bone marrow or in an extramedullary location.
MCID: MC00097684
PMOID: PMO:00001258
Subclass_of: Hematological neoplasm
Synonym: Extramedullary Plasmacytoma
Synonym: Extramedullary plasmacytoma
Synonym: Extramedullary plasmacytoma (clinical disorder) (disorder)
Synonym: Extramedullary plasmacytoma (clinical disorder) [Ambiguous]
Synonym: Extramedullary plasmacytoma (clinical)
Synonym: Extramedullary plasmacytoma NOS
Synonym: Extraosseous Plasmacytoma
Synonym: M plsma cel neo,extram p'cytom
Synonym: Malignant plasma cell neoplasm, extramedullary plasmacytoma
Synonym: Malignant plasma cell neoplasm, extramedullary plasmacytoma (disorder)
Tree Number: T3.2.10.7
database_cross_reference: CHV:0000027203
database_cross_reference: DO:DOID:3720
database_cross_reference: DO:DOID:3721
database_cross_reference: HPO:HP:0011857
database_cross_reference: ICD10:C90.2
database_cross_reference: ICD10AM:C90.2
database_cross_reference: ICD10CM:C90.2
database_cross_reference: ICD10CM:C90.20
database_cross_reference: MDR:10066883
database_cross_reference: MEDCIN:271576
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4002
database_cross_reference: NCI:TCGA
database_cross_reference: PDQ:CDR0000041865
database_cross_reference: RCD:B6300
database_cross_reference: SNMI:M-97313
database_cross_reference: SNOMEDCT_US:10639003
database_cross_reference: SNOMEDCT_US:109987008
database_cross_reference: SNOMEDCT_US:128921005
database_cross_reference: SNOMEDCT_US:188718006

Abnormality of connective tissue
type: Class
subclass of: Phenotypic Abnormality
Definition: Any abnormality of the soft tissues, including both connective tissue (tendons, ligaments, fascia, fibrous tissues, and fat).
MCID: MC01002933
PMOID: PMO:00001259
Subclass_of: Phenotypic Abnormality
Tree Number: T3.3
database_cross_reference: HPO:HP:0003549

Abnormal adipose tissue morphology
type: Class
subclass of: Abnormality of connective tissue
Definition: An abnormality of adipose tissue, which is loose connective tissue composed of adipocytes.
PMOID: PMO:00001260
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.1

Abnormality of facial adipose tissue
type: Class
subclass of: Abnormal adipose tissue morphology
MCID: MC01003118
PMOID: PMO:00001261
Subclass_of: Abnormal adipose tissue morphology
Synonym: Abnormality of facial fat
Synonym: Deformity of facial adipose tissue
Synonym: Malformation of facial adipose tissue
Tree Number: T3.3.1.1
database_cross_reference: HPO:HP:0000291

Abnormality of subcutaneous fat tissue
type: Class
subclass of: Abnormal adipose tissue morphology
MCID: MC01003078
PMOID: PMO:00001265
Subclass_of: Abnormal adipose tissue morphology
Synonym: Abnormality of fatty tissue below the skin
Tree Number: T3.3.1.2
database_cross_reference: HPO:HP:0001001

Adipocyte hypertrophy
type: Class
subclass of: Abnormal adipose tissue morphology
Definition: An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy.
MCID: MC01396600
PMOID: PMO:00001274
Subclass_of: Abnormal adipose tissue morphology
Synonym: Fat cell hypertrophy
Tree Number: T3.3.1.3
database_cross_reference: HPO:HP:0030759

Decreased adipose tissue
type: Class
subclass of: Abnormal adipose tissue morphology
MCID: MC01000890
PMOID: PMO:00001275
Subclass_of: Abnormal adipose tissue morphology
Synonym: Decreased fat tissue
Synonym: Fat tissue decreased
Tree Number: T3.3.1.4
database_cross_reference: HPO:HP:0040063
database_cross_reference: MDR:10073170

Diet-resistant subcutaneous adipose tissue
type: Class
subclass of: Abnormal adipose tissue morphology
Definition: Areas of subcutanous fat tissue that are resistant to (do not respond as expected to) diet, life-style alteration, or bariatric surgery.
MCID: MC01397809
PMOID: PMO:00001285
Subclass_of: Abnormal adipose tissue morphology
Tree Number: T3.3.1.5
database_cross_reference: HPO:HP:0025384

Increased adipose tissue
type: Class
subclass of: Abnormal adipose tissue morphology
Definition: An increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell).
MCID: MC01398991
PMOID: PMO:00001287
Subclass_of: Abnormal adipose tissue morphology
Synonym: Increased fat tissue
Tree Number: T3.3.1.6
database_cross_reference: HPO:HP:0009126

Lipodystrophy
type: Class
subclass of: Abnormal adipose tissue morphology
Definition: Degenerative changes of the fat tissue.
MCID: MC00007597
PMOID: PMO:00001290
Subclass_of: Abnormal adipose tissue morphology
Synonym: CUTANEOUS LIPODYSTROPHY
Synonym: Dystrophy of fatty tissue
Synonym: Dystrophy, fatty tissue
Synonym: LIPODYSTROPHY
Synonym: Lipodystrophies
Synonym: Lipodystrophy (disorder)
Synonym: Lipodystrophy NOS
Synonym: Lipodystrophy NOS (disorder)
Synonym: Lipodystrophy [Disease/Finding]
Synonym: Lipodystrophy, NOS
Tree Number: T3.3.1.7
database_cross_reference: AOD:0000005730
database_cross_reference: CHV:0000007457
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000169
database_cross_reference: CSP:1745-6360
database_cross_reference: CST:LIPODYSTROPHY
database_cross_reference: DO:DOID:811
database_cross_reference: HPO:HP:0009125
database_cross_reference: ICD10CM:E88.1
database_cross_reference: ICD9CM:272.6
database_cross_reference: ICPC2P:T93017
database_cross_reference: ICPC2P:T99075
database_cross_reference: MDR:10024606
database_cross_reference: MDR:10024608
database_cross_reference: MEDCIN:338592
database_cross_reference: MSH:D008060
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C97093
database_cross_reference: NDFRT:N0000001850
database_cross_reference: OMIM:MTHU037286
database_cross_reference: RCD:C326z
database_cross_reference: RCD:XE11X
database_cross_reference: SNM:M-56020
database_cross_reference: SNMI:DB-61700
database_cross_reference: SNOMEDCT_US:190789006
database_cross_reference: SNOMEDCT_US:190790002
database_cross_reference: SNOMEDCT_US:71325002

Lower extremity subcutanous fat hypertrophy
type: Class
subclass of: Abnormal adipose tissue morphology
Definition: An abnormal increase in the amount of subcutaneous fat in the legs.
MCID: MC01399634
PMOID: PMO:00001294
Subclass_of: Abnormal adipose tissue morphology
Tree Number: T3.3.1.8
database_cross_reference: HPO:HP:0031451

Neoplasm of fatty tissue
type: Class
subclass of: Abnormal adipose tissue morphology
Definition: A tumor (abnormal growth of tissue) of adipose tissue.
MCID: MC01000429
PMOID: PMO:00001295
Subclass_of: Abnormal adipose tissue morphology
Synonym: Tumor of fatty tissue
Tree Number: T3.3.1.9
database_cross_reference: HPO:HP:0200013

Abnormal Sharpey fiber morphology
type: Class
subclass of: Abnormality of connective tissue
Definition: An abnormality of Sharpey's fibers (bone fibers, or perforating fibers), which are a matrix of connective tissue consisting of bundles of strong collagenous fibres connecting periosteum to bone.
PMOID: PMO:00001306
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.2

Enthesitis
type: Class
subclass of: Abnormal Sharpey fiber morphology
MCID: MC00433419
PMOID: PMO:00001307
Subclass_of: Abnormal Sharpey fiber morphology
Synonym: Enthesitis (disorder)
Synonym: Inflammation of sharpey fibers
Synonym: enthesitis
Tree Number: T3.3.2.1
database_cross_reference: CHV:0000057176
database_cross_reference: HPO:HP:0100686
database_cross_reference: ICPC2P:L87021
database_cross_reference: MDR:10058497
database_cross_reference: NCI:C114470
database_cross_reference: NCI_NICHD:C114470
database_cross_reference: RCD:Xa0lk
database_cross_reference: SNOMEDCT_US:359643005

Abnormality of the fascia
type: Class
subclass of: Abnormality of connective tissue
Definition: An abnormality of fascia.
MCID: MC01000532
PMOID: PMO:00001308
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.3
database_cross_reference: HPO:HP:0100536

Cellulitis
type: Class
subclass of: Abnormality of connective tissue
Definition: A bacterial infection and inflammation of the skin und subcutaneous tissues.
MCID: MC00002464
PMOID: PMO:00001309
Subclass_of: Abnormality of connective tissue
Synonym: CELLULITIS
Synonym: Cellulitis (disorder)
Synonym: Cellulitis (morphologic abnormality)
Synonym: Cellulitis NOS
Synonym: Cellulitis NOS (disorder)
Synonym: Cellulitis [Disease/Finding]
Synonym: Cellulitis, NOS
Synonym: Cellulitis, unspecified
Synonym: Inflammation of subcutaneous tissue
Synonym: Subcutaneous tissue inflamed
Tree Number: T3.3.4
database_cross_reference: AOD:0000023000
database_cross_reference: CCPSS:1017421
database_cross_reference: CHV:0000002607
database_cross_reference: COSTAR:163
database_cross_reference: CSP:0729-7208
database_cross_reference: CSP:0944-6244
database_cross_reference: CST:CELLULITIS
database_cross_reference: DO:DOID:3488
database_cross_reference: DXP:U000311
database_cross_reference: DXP:U000578
database_cross_reference: HPO:HP:0100658
database_cross_reference: ICD10:L03
database_cross_reference: ICD10:L03.9
database_cross_reference: ICD10AM:L03
database_cross_reference: ICD10AM:L03.9
database_cross_reference: ICD10CM:L03.90
database_cross_reference: ICPC2P:S10002
database_cross_reference: ICPC2P:S76005
database_cross_reference: LCH:U000875
database_cross_reference: LCH_NW:sh85021701
database_cross_reference: MDR:10007882
database_cross_reference: MEDCIN:30907
database_cross_reference: MEDLINEPLUS:1227
database_cross_reference: MSH:D002481
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:682.9
database_cross_reference: NCI:C26715
database_cross_reference: NCI_FDA:1768
database_cross_reference: NCI_NCI-GLOSS:CDR0000044789
database_cross_reference: NCI_NICHD:C26715
database_cross_reference: NDFRT:N0000000707
database_cross_reference: OMIM:MTHU034281
database_cross_reference: RCD:M03z0
database_cross_reference: SNM:M-40200
database_cross_reference: SNMI:M-41650
database_cross_reference: SNOMEDCT_US:128045006
database_cross_reference: SNOMEDCT_US:156317003
database_cross_reference: SNOMEDCT_US:191132005
database_cross_reference: SNOMEDCT_US:200693005
database_cross_reference: SNOMEDCT_US:385627004
database_cross_reference: SNOMEDCT_US:74276003
database_cross_reference: SNOMEDCT_VET:128045006

Congenital mesoblastic nephroma
type: Class
subclass of: Abnormality of connective tissue
Definition: Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by ultrasound or within the first 3 months of life. It contains fibroblastic cells (connective tissue cells), and may spread to the other kidney or to nearby tissue.
MCID: MC00455392
PMOID: PMO:00001310
Subclass_of: Abnormality of connective tissue
Synonym: CMN
Synonym: CONGEN MESOBLASTIC NEPHROMA
Synonym: Cmn
Synonym: Congenital Mesoblastic Nephroma
Synonym: Congenital Mesoblastic Nephromas
Synonym: Mesoblastic Nephroma
Synonym: Mesoblastic Nephroma, Congenital
Synonym: Mesoblastic Nephromas, Congenital
Synonym: Nephroma, Congenital Mesoblastic
Synonym: Nephromas, Congenital Mesoblastic
Tree Number: T3.3.5
database_cross_reference: DO:DOID:4773
database_cross_reference: HPO:HP:0100881
database_cross_reference: MSH:D018201
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C6569
database_cross_reference: NCI_CDISC:C6569
database_cross_reference: NCI_NCI-GLOSS:CDR0000534218
database_cross_reference: NCI_NICHD:C6569

Flexion contracture
type: Class
subclass of: Abnormality of connective tissue
Definition: A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints.
MCID: MC00116142
PMOID: PMO:00001311
Subclass_of: Abnormality of connective tissue
Synonym: CONTRACTURE FLEXION
Synonym: Flexion contracture (disorder)
Synonym: Flexion contracture (qualifier value)
Synonym: Flexion contractures
Synonym: Flexion deformity
Synonym: Flexion deformity (disorder)
Synonym: Flexion deformity (morphologic abnormality)
Synonym: Flexion deformity, site unspecified
Synonym: Flexion deformity, unspecified site
Synonym: contracture flexion
Tree Number: T3.3.6
database_cross_reference: CCPSS:0016619
database_cross_reference: CHV:0000029608
database_cross_reference: CHV:0000056873
database_cross_reference: HPO:HP:0001371
database_cross_reference: ICD10:M21.2
database_cross_reference: ICD10AM:M21.2
database_cross_reference: ICD10AM:M21.29
database_cross_reference: ICD10CM:M21.2
database_cross_reference: ICD10CM:M21.20
database_cross_reference: MEDCIN:335775
database_cross_reference: OMIM:MTHU003721
database_cross_reference: RCD:N369.
database_cross_reference: RCD:XC0cz
database_cross_reference: SNM:M-31080
database_cross_reference: SNMI:M-31710
database_cross_reference: SNOMEDCT_US:156547000
database_cross_reference: SNOMEDCT_US:203598005
database_cross_reference: SNOMEDCT_US:264526003
database_cross_reference: SNOMEDCT_US:268064000
database_cross_reference: SNOMEDCT_US:385522000
database_cross_reference: SNOMEDCT_US:88565003

Congenital contracture
type: Class
subclass of: Flexion contracture
Definition: One or more flexion contractures (a bent joint that cannot be straightened actively or passively) that are present at birth.
MCID: MC00115979
PMOID: PMO:00001312
Subclass_of: Flexion contracture
Synonym: Congenital contracture (morphologic abnormality)
Synonym: Congenital contracture, NOS
Synonym: Congenital contractures
Synonym: Congenital joint contractures
Synonym: Contracture, congenital
Synonym: Contractures, congenital
Synonym: congenital contractures
Tree Number: T3.3.6.1
database_cross_reference: HPO:HP:0002803
database_cross_reference: OMIM:MTHU003115
database_cross_reference: OMIM:MTHU011748
database_cross_reference: OMIM:MTHU056249
database_cross_reference: SNM:M-22640
database_cross_reference: SNMI:M-20140
database_cross_reference: SNOMEDCT_US:91287001

Contractures of the large joints
type: Class
subclass of: Flexion contracture
MCID: MC01397416
PMOID: PMO:00001319
Subclass_of: Flexion contracture
Tree Number: T3.3.6.2
database_cross_reference: HPO:HP:0005781

Decreased cervical spine flexion due to contractures of posterior cervical muscles
type: Class
subclass of: Flexion contracture
MCID: MC01397516
PMOID: PMO:00001320
Subclass_of: Flexion contracture
Synonym: Contracture of post-cervical muscles
Tree Number: T3.3.6.3
database_cross_reference: HPO:HP:0004631

Flexion contracture of digit
type: Class
subclass of: Flexion contracture
Definition: A bent (flexed) finger or toe joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints.
MCID: MC01398368
PMOID: PMO:00001321
Subclass_of: Flexion contracture
Tree Number: T3.3.6.4
database_cross_reference: HPO:HP:0030044

Joint contractures involving the joints of the feet
type: Class
subclass of: Flexion contracture
Definition: Contractures of one ore more joints of the feet meaning chronic loss of joint motion due to structural changes in non-bony tissue.
MCID: MC01399414
PMOID: PMO:00001337
Subclass_of: Flexion contracture
Tree Number: T3.3.6.5
database_cross_reference: HPO:HP:0100492

Limb joint contracture
type: Class
subclass of: Flexion contracture
Definition: A contrqacture (chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin) that prevent normal movement of one or more joints of the limbs.
MCID: MC01399510
PMOID: PMO:00001338
Subclass_of: Flexion contracture
Synonym: Limb contractures
Tree Number: T3.3.6.6
database_cross_reference: HPO:HP:0003121

Multiple joint contractures
type: Class
subclass of: Flexion contracture
MCID: MC00062533
PMOID: PMO:00001346
Subclass_of: Flexion contracture
Synonym: Contracture of joint of multiple sites
Synonym: Contracture of joint of multiple sites (disorder)
Synonym: Contracture of joint, multiple sites
Synonym: Contracture of multiple joints
Synonym: Contracture of multiple joints (disorder)
Synonym: Jt contracture-mult jts
Synonym: contracture of multiple sites
Synonym: contracture of multiple sites (diagnosis)
Tree Number: T3.3.6.7
database_cross_reference: HPO:HP:0002828
database_cross_reference: ICD10AM:M24.50
database_cross_reference: ICD9CM:718.49
database_cross_reference: MDR:10010823
database_cross_reference: MEDCIN:94087
database_cross_reference: OMIM:MTHU004616
database_cross_reference: RCD:N0849
database_cross_reference: SNMI:D1-2237A
database_cross_reference: SNOMEDCT_US:156548005
database_cross_reference: SNOMEDCT_US:19393004
database_cross_reference: SNOMEDCT_US:202264009

Progressive flexion contractures
type: Class
subclass of: Flexion contracture
Definition: Progressively worsening joint contractures.
MCID: MC01400563
PMOID: PMO:00001347
Subclass_of: Flexion contracture
Synonym: Joint contractures, progressive
Tree Number: T3.3.6.8
database_cross_reference: HPO:HP:0005876

Hernia
type: Class
subclass of: Abnormality of connective tissue
MCID: MC00006166
PMOID: PMO:00001348
Subclass_of: Abnormality of connective tissue
Synonym: HERNIA
Synonym: HERNIATION
Synonym: Hernia (K40-K46)
Synonym: Hernia (morphologic abnormality)
Synonym: Hernia - lesion
Synonym: Hernia - lesion (qualifier value)
Synonym: Hernia NOS
Synonym: Hernia [Disease/Finding]
Synonym: Hernia, NOS
Synonym: Hernias
Tree Number: T3.3.7
database_cross_reference: AOD:0000004460
database_cross_reference: BI:BI00271
database_cross_reference: CCPSS:0022658
database_cross_reference: CCPSS:1006190
database_cross_reference: CHV:0000006079
database_cross_reference: COSTAR:360
database_cross_reference: CSP:0944-5779
database_cross_reference: CST:HERNIA
database_cross_reference: HPO:HP:0100790
database_cross_reference: ICD10:K40-K46.9
database_cross_reference: ICD10AM:K40-K46.9
database_cross_reference: ICD10CM:K40-K46
database_cross_reference: ICD10CM:K46
database_cross_reference: ICPC2P:D91001
database_cross_reference: LCH:U002183
database_cross_reference: LCH_NW:sh85060424
database_cross_reference: MDR:10019909
database_cross_reference: MDR:10019918
database_cross_reference: MEDCIN:96160
database_cross_reference: MEDLINEPLUS:283
database_cross_reference: MSH:D006547
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34685
database_cross_reference: NCI_CDISC:C34685
database_cross_reference: NCI_FDA:2240
database_cross_reference: NCI_NCI-GLOSS:CDR0000630906
database_cross_reference: NCI_NICHD:C34685
database_cross_reference: NDFRT:N0000001516
database_cross_reference: OMIM:MTHU012924
database_cross_reference: OMIM:MTHU014363
database_cross_reference: RCD:J3...
database_cross_reference: RCD:Jyu3.
database_cross_reference: RCD:Xa0FV
database_cross_reference: RCDSY:Jyu3.
database_cross_reference: SNM:M-31600
database_cross_reference: SNM:M-31650
database_cross_reference: SNM:U000294
database_cross_reference: SNMI:M-31500
database_cross_reference: SNOMEDCT_US:14778003
database_cross_reference: SNOMEDCT_US:197529008
database_cross_reference: SNOMEDCT_US:276915000
database_cross_reference: SNOMEDCT_US:359801000
database_cross_reference: SNOMEDCT_US:362633009
database_cross_reference: SNOMEDCT_US:414403008
database_cross_reference: SNOMEDCT_US:52515009

Congenital diaphragmatic hernia
type: Class
subclass of: Hernia
Definition: The presence of a hernia of the diaphragm present at birth.
MCID: MC00006173
PMOID: PMO:00001349
Subclass_of: Hernia
Synonym: DIAPHRAGMATIC HERNIA
Synonym: Diaphragmatic Hernia
Synonym: Diaphragmatic Hernias
Synonym: Diaphragmatic hernia
Synonym: Diaphragmatic hernia (disorder)
Synonym: Diaphragmatic hernia NOS
Synonym: Diaphragmatic hernia NOS (disorder)
Synonym: Diaphragmatic hernia, NOS
Synonym: Diaphragmatic hernias
Synonym: HERNIA, DIAPHRAGMATIC
Tree Number: T3.3.7.1
database_cross_reference: AOD:0000005696
database_cross_reference: CCPSS:0058559
database_cross_reference: CHV:0000006080
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:3827
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001962
database_cross_reference: ICD10:K44
database_cross_reference: ICD10AM:K44
database_cross_reference: ICD10CM:K44
database_cross_reference: ICD10CM:K44.9
database_cross_reference: ICPC2P:D90001
database_cross_reference: LCH_NW:sh85037586
database_cross_reference: MDR:10012713
database_cross_reference: MDR:10012714
database_cross_reference: MDR:10012717
database_cross_reference: MEDCIN:30146
database_cross_reference: MEDLINEPLUS:283
database_cross_reference: MSH:D006548
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34687
database_cross_reference: NCI_NICHD:C34687
database_cross_reference: NDFRT:N0000001517
database_cross_reference: OMIM:MTHU001436
database_cross_reference: RCD:J34z.
database_cross_reference: RCD:XE0ab
database_cross_reference: RCD:XE0ac
database_cross_reference: SNMI:D5-60600
database_cross_reference: SNOMEDCT_US:155748004
database_cross_reference: SNOMEDCT_US:155750007
database_cross_reference: SNOMEDCT_US:196901006
database_cross_reference: SNOMEDCT_US:196911004
database_cross_reference: SNOMEDCT_US:196912006
database_cross_reference: SNOMEDCT_US:266444006
database_cross_reference: SNOMEDCT_US:266511003
database_cross_reference: SNOMEDCT_US:39839004

Genital hernia
type: Class
subclass of: Hernia
MCID: MC01000479
PMOID: PMO:00001353
Subclass_of: Hernia
Tree Number: T3.3.7.2
database_cross_reference: HPO:HP:0100823

Hernia of the abdominal wall
type: Class
subclass of: Hernia
Definition: The presence of a hernia in the abdominal wall.
MCID: MC00513616
PMOID: PMO:00001355
Subclass_of: Hernia
Synonym: External abdominal hernia
Synonym: Hernia abdominal wall
Synonym: Hernia of abdominal wall
Synonym: Hernia of abdominal wall (disorder)
Synonym: hernia of abdominal wall (diagnosis)
Tree Number: T3.3.7.3
database_cross_reference: HPO:HP:0004299
database_cross_reference: MDR:10019911
database_cross_reference: MEDCIN:360857
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:128545000

Increased connective tissue
type: Class
subclass of: Abnormality of connective tissue
Definition: The presence of an abnormally increased amount of connective tissue.
MCID: MC01399047
PMOID: PMO:00001361
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.8
database_cross_reference: HPO:HP:0009025

Musculotendinous retraction
type: Class
subclass of: Abnormality of connective tissue
Definition: Abnormal reduction in length of a tendon which tends to pull (retract) the attached muscle tissue with shortening of the muscle fibers often accompanied by atrophy and fatty degeneration of the affected muscle tissue.
MCID: MC01399915
PMOID: PMO:00001362
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.9
database_cross_reference: HPO:HP:0031462

Scarring
type: Class
subclass of: Abnormality of connective tissue
MCID: MC00002901
PMOID: PMO:00001363
Subclass_of: Abnormality of connective tissue
Synonym: Cicatrisation
Synonym: Cicatrization
Synonym: Healing scar
Synonym: SKIN SCARRING
Synonym: Scarred
Synonym: Scarring (morphologic abnormality)
Synonym: cicatrisation
Synonym: cicatrization
Synonym: healing scar
Synonym: healing scars
Tree Number: T3.3.10
database_cross_reference: AOD:0000001779
database_cross_reference: CHV:0000011072
database_cross_reference: CHV:0000024542
database_cross_reference: DXP:U003692
database_cross_reference: HPO:HP:0100699
database_cross_reference: LNC:LA19047-2
database_cross_reference: LNC:LA7471-1
database_cross_reference: MSH:D002921
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X78zr
database_cross_reference: SNMI:M-78290
database_cross_reference: SNOMEDCT_US:123121007
database_cross_reference: SNOMEDCT_US:48677004

Chorioretinal scar
type: Class
subclass of: Scarring
Definition: Fibrous connective tissue resulting from incomplete healing of a wound (i.e., a scar) located in the choroid and retina or the eye.
MCID: MC00002786
PMOID: PMO:00001364
Subclass_of: Scarring
Synonym: Chorioretinal scar (disorder)
Synonym: Chorioretinal scar NOS
Synonym: Chorioretinal scar, NOS
Synonym: Chorioretinal scar, unspecified
Synonym: Chorioretinal scars
Synonym: Chorioretinal scars NOS
Synonym: Chorioretinal scars NOS (disorder)
Synonym: Unspecified chorioretinal scar
Synonym: Unspecified chorioretinal scar (disorder)
Synonym: Unspecified chorioretinal scars
Tree Number: T3.3.10.1
database_cross_reference: DO:DOID:11086
database_cross_reference: HPO:HP:0007777
database_cross_reference: ICD10:H31.0
database_cross_reference: ICD10AM:H31.0
database_cross_reference: ICD10CM:H31.0
database_cross_reference: ICD10CM:H31.00
database_cross_reference: ICD9CM:363.3
database_cross_reference: ICD9CM:363.30
database_cross_reference: MDR:10008766
database_cross_reference: MDR:10008767
database_cross_reference: MDR:10008768
database_cross_reference: MEDCIN:11480
database_cross_reference: MEDCIN:334861
database_cross_reference: RCD:F433.
database_cross_reference: RCD:F4330
database_cross_reference: RCD:F433z
database_cross_reference: SNM:M-49060
database_cross_reference: SNMI:DA-71200
database_cross_reference: SNOMEDCT_US:193455005
database_cross_reference: SNOMEDCT_US:193460009
database_cross_reference: SNOMEDCT_US:53854005

Abnormality of head or neck
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of head and neck.
MCID: MC01000366
PMOID: PMO:00001365
Subclass_of: Phenotypic Abnormality
Synonym: Head and neck abnormality
Tree Number: T3.4
database_cross_reference: HPO:HP:0000152

Abnormality of the head
type: Class
subclass of: Abnormality of head or neck
Definition: An abnormality of the head.
MCID: MC01000361
PMOID: PMO:00001366
Subclass_of: Abnormality of head or neck
Synonym: Abnormal head
Synonym: Head abnormality
Tree Number: T3.4.1
database_cross_reference: HPO:HP:0000234

Abnormality of the face
type: Class
subclass of: Abnormality of the head
Definition: An abnormality of the face.
MCID: MC01003122
PMOID: PMO:00001367
Subclass_of: Abnormality of the head
Synonym: Abnormal face
Synonym: Abnormality of the countenance
Synonym: Abnormality of the physiognomy
Synonym: Abnormality of the visage
Synonym: Anomaly of face
Synonym: Facial abnormality
Synonym: Facial anomaly
Tree Number: T3.4.1.1
database_cross_reference: HPO:HP:0000271

Abnormality of the pharynx
type: Class
subclass of: Abnormality of the head
Definition: An anomaly of the pharynx, i.e., of the tubular structure extending from the base of the skull superiorly to the esophageal inlet inferiorly.
MCID: MC01003098
PMOID: PMO:00002216
Subclass_of: Abnormality of the head
Tree Number: T3.4.1.2
database_cross_reference: HPO:HP:0000600

Abnormality of the scalp
type: Class
subclass of: Abnormality of the head
Definition: Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows.
MCID: MC01003011
PMOID: PMO:00002230
Subclass_of: Abnormality of the head
Synonym: Anomaly of scalp
Tree Number: T3.4.1.3
database_cross_reference: HPO:HP:0001965

Abnormality of the skull
type: Class
subclass of: Abnormality of the head
Definition: An abnormality of the skull, the bony framework of the head which is comprised of eight cranial and fourteen facial bones.
MCID: MC00080197
PMOID: PMO:00002233
Subclass_of: Abnormality of the head
Synonym: Abnormality of the skull bones
Synonym: CRANIAL DEFORMITY
Synonym: Deformity of the skull
Synonym: MALFORMATION SKULL
Synonym: Malformation skull
Synonym: SKULL DEFORMITY
Synonym: Skull malformation
Synonym: Skull malformation NOS
Synonym: abnormalities skull
Synonym: cranial deformities
Tree Number: T3.4.1.4
database_cross_reference: CCPSS:0056624
database_cross_reference: CHV:0000023641
database_cross_reference: CSP:0725-7823
database_cross_reference: CST:ANOMALY CONGEN MS
database_cross_reference: DXP:U000890
database_cross_reference: HPO:HP:0000929
database_cross_reference: HPO:HP:0001363
database_cross_reference: MDR:10025530
database_cross_reference: MDR:10040963
database_cross_reference: MDR:10062348
database_cross_reference: MEDCIN:6387

Fixed head retroflexion
type: Class
subclass of: Abnormality of the head
Definition: Head is bent in the posterior direction in a permanent fashion.
MCID: MC01398340
PMOID: PMO:00002472
Subclass_of: Abnormality of the head
Tree Number: T3.4.1.5
database_cross_reference: HPO:HP:0031178

Abnormality of the neck
type: Class
subclass of: Abnormality of head or neck
Definition: An abnormality of the neck.
MCID: MC00091250
PMOID: PMO:00002473
Subclass_of: Abnormality of head or neck
Synonym: 4-B2 CONGENITAL ANOMALIES OF THE NECK
Synonym: Anomaly of the neck
Synonym: CONGENITAL ANOMALIES OF THE NECK
Synonym: Congenital anomaly of neck
Synonym: Congenital anomaly of neck (disorder)
Synonym: Congenital anomaly of neck NOS
Synonym: Congenital anomaly of neck NOS (disorder)
Synonym: Congenital anomaly of neck, NOS
Synonym: Congenital deformity of neck
Synonym: Congenital deformity of neck, NOS
Tree Number: T3.4.2
database_cross_reference: HPO:HP:0000464
database_cross_reference: RCD:P4z0.
database_cross_reference: RCD:X77tS
database_cross_reference: SNMI:D4-B2000
database_cross_reference: SNOMEDCT_US:156903001
database_cross_reference: SNOMEDCT_US:204288007
database_cross_reference: SNOMEDCT_US:268311006
database_cross_reference: SNOMEDCT_US:40052002

Branchial anomaly
type: Class
subclass of: Abnormality of the neck
Definition: Congenital developmental defect arising from the primitive branchial apparatus.
MCID: MC00614709
PMOID: PMO:00002474
Subclass_of: Abnormality of the neck
Synonym: Abnormality of branchial apparatus
Synonym: Abnormality of branchial arch
Synonym: Branchial abnormality
Synonym: Branchial anomalies
Tree Number: T3.4.2.1
database_cross_reference: HPO:HP:0009794
database_cross_reference: OMIM:MTHU019218

Broad neck
type: Class
subclass of: Abnormality of the neck
Definition: Increased side-to-side width of the neck.
MCID: MC01397163
PMOID: PMO:00002478
Subclass_of: Abnormality of the neck
Synonym: Increased width of neck
Synonym: Wide neck
Tree Number: T3.4.2.2
database_cross_reference: HPO:HP:0000475

Cystic hygroma
type: Class
subclass of: Abnormality of the neck
Definition: A cystic lymphatic lesion of the neck.
MCID: MC00067474
PMOID: PMO:00002479
Subclass_of: Abnormality of the neck
Synonym: CYSTIC HYGROMA
Synonym: Colli, Cystic Hygroma
Synonym: Cystic Hygroma
Synonym: Cystic Hygroma Colli
Synonym: Cystic Hygromas
Synonym: Cystic Lymphangioma
Synonym: Cystic Lymphangiomas
Synonym: Cystic hygroma (disorder)
Synonym: Cystic hygroma of the neck
Synonym: Cystic lymphangioma
Tree Number: T3.4.2.3
database_cross_reference: CCPSS:0059029
database_cross_reference: CHV:0000020973
database_cross_reference: DO:DOID:3081
database_cross_reference: HPO:HP:0000476
database_cross_reference: ICD10AM:M9173/0
database_cross_reference: ICPC2P:K72008
database_cross_reference: ICPC2P:K99048
database_cross_reference: MDR:10011769
database_cross_reference: MDR:10020543
database_cross_reference: MDR:10058949
database_cross_reference: MEDCIN:362060
database_cross_reference: MSH:D018191
database_cross_reference: NCI:C3724
database_cross_reference: NCI_NICHD:C3724
database_cross_reference: NDFRT:N0000003665
database_cross_reference: OMIM:MTHU014835
database_cross_reference: RCD:BBU4.
database_cross_reference: SNM:M-9173/0
database_cross_reference: SNMI:M-91730
database_cross_reference: SNOMEDCT_US:399882002
database_cross_reference: SNOMEDCT_US:40225001
database_cross_reference: SNOMEDCT_US:423984004

Increased adipose tissue around the neck
type: Class
subclass of: Abnormality of the neck
Definition: An increased amount of subcutaneous fat tissue around the neck.
MCID: MC01398992
PMOID: PMO:00002482
Subclass_of: Abnormality of the neck
Synonym: Increased fat around the neck
Tree Number: T3.4.2.4
database_cross_reference: HPO:HP:0000468

Limitation of neck motion
type: Class
subclass of: Abnormality of the neck
PMOID: PMO:00002483
Subclass_of: Abnormality of the neck
Tree Number: T3.4.2.5

Long neck
type: Class
subclass of: Abnormality of the neck
Definition: Increased inferior-superior length of the neck.
MCID: MC01399567
PMOID: PMO:00002488
Subclass_of: Abnormality of the neck
Synonym: Cervical elongation
Synonym: Elongated neck
Synonym: Increased cervical length
Synonym: Increased length of neck
Tree Number: T3.4.2.6
database_cross_reference: HPO:HP:0000472

Redundant neck skin
type: Class
subclass of: Abnormality of the neck
Definition: Excess skin around the neck, often lying in horizontal folds.
MCID: MC01400895
PMOID: PMO:00002489
Subclass_of: Abnormality of the neck
Synonym: Excess neck skin
Synonym: Excess skin over the neck
Synonym: Redundant nuchal skin
Synonym: Redundant skin folds of neck
Synonym: Redundant skin over the neck
Tree Number: T3.4.2.7
database_cross_reference: HPO:HP:0005989

Short neck
type: Class
subclass of: Abnormality of the neck
Definition: Diminished length of the neck.
MCID: MC01401117
PMOID: PMO:00002490
Subclass_of: Abnormality of the neck
Synonym: Cervical shortening
Synonym: Decreased cervical height
Synonym: Decreased cervical length
Synonym: Decreased length of neck
Tree Number: T3.4.2.8
database_cross_reference: HPO:HP:0000470

Thickened nuchal skin fold
type: Class
subclass of: Abnormality of the neck
Definition: A thickening of the skin thickness in the posterior aspect of the fetal neck. A nuchal fold measurement is obtained in a transverse section of the fetal head at the level of the cavum septum pellucidum and thalami, angled posteriorly to include the cerebellum. The measurement is taken from the outer edge of the occiput bone to the outer skin limit directly in the midline. A measurement 6 mm or more is considered significant between 18 and 24 weeks and a measurement of 5 mm or more is considered significant at 16 to 18 weeks (pmid:16100637).
MCID: MC01401465
PMOID: PMO:00002491
Subclass_of: Abnormality of the neck
Synonym: Excess nuchal skin
Synonym: Thickened nuchal skin
Synonym: Thickened skin folds of neck
Synonym: Thickened skin over the neck
Tree Number: T3.4.2.9
database_cross_reference: HPO:HP:0000474

Webbed neck
type: Class
subclass of: Abnormality of the neck
Definition: Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline.
MCID: MC00070775
PMOID: PMO:00002492
Subclass_of: Abnormality of the neck
Synonym: Congenital neck webbing unsp.
Synonym: Congenital neck webbing, unspecified
Synonym: Congenital neck webbing, unspecified (disorder)
Synonym: Congenital webbing of neck
Synonym: Congenital webbing of neck (disorder)
Synonym: Congenital webbing of neck NOS
Synonym: Congenital webbing of neck NOS (disorder)
Synonym: NECK WEBBED
Synonym: Neck Webbing
Synonym: Neck webbing
Tree Number: T3.4.2.10
database_cross_reference: CHV:0000021345
database_cross_reference: DXP:U002784
database_cross_reference: HPO:HP:0000465
database_cross_reference: ICD10:Q18.3
database_cross_reference: ICD10AM:Q18.3
database_cross_reference: ICD10CM:Q18.3
database_cross_reference: ICD9CM:744.5
database_cross_reference: MDR:10047876
database_cross_reference: MDR:10051972
database_cross_reference: MEDCIN:6961
database_cross_reference: MEDCIN:98996
database_cross_reference: MTHICD9:744.5
database_cross_reference: NCI:C87130
database_cross_reference: NCI_NICHD:C87130
database_cross_reference: OMIM:MTHU036403
database_cross_reference: OMIM:MTHU036551
database_cross_reference: OMIM:MTHU038333
database_cross_reference: OMIM:MTHU048699
database_cross_reference: RCD:P45..
database_cross_reference: RCD:P450.
database_cross_reference: RCD:P45z.
database_cross_reference: RCD:X76gB
database_cross_reference: SNM:M-25120
database_cross_reference: SNMI:D4-B2050
database_cross_reference: SNOMEDCT_US:11731003
database_cross_reference: SNOMEDCT_US:204279003
database_cross_reference: SNOMEDCT_US:204280000
database_cross_reference: SNOMEDCT_US:204281001
database_cross_reference: SNOMEDCT_US:249667006
database_cross_reference: SNOMEDCT_US:271281009

Abnormality of limbs
type: Class
subclass of: Phenotypic Abnormality
MCID: MC00081089
PMOID: PMO:00002493
Subclass_of: Phenotypic Abnormality
Synonym: Abnormal limbs
Synonym: Deformity of limb
Synonym: Deformity of limb (finding)
Synonym: EXTREMITY DEFORMITY
Synonym: Extremity deformities
Synonym: Limb deformities
Synonym: Limb deformities NOS
Synonym: Limb deformity
Synonym: Limb deformity NOS
Synonym: abnormalities limb
Tree Number: T3.5
database_cross_reference: CHV:0000024191
database_cross_reference: DXP:U001220
database_cross_reference: HPO:HP:0040064
database_cross_reference: MDR:10012139
database_cross_reference: MDR:10024495
database_cross_reference: MDR:10053652
database_cross_reference: OMIM:MTHU041883
database_cross_reference: SNOMEDCT_US:268132009
database_cross_reference: SNOMEDCT_US:445144002
database_cross_reference: SNOMEDCT_VET:34281000009104

Abnormality of limb bone
type: Class
subclass of: Abnormality of limbs
MCID: MC01000887
PMOID: PMO:00002494
Subclass_of: Abnormality of limbs
Tree Number: T3.5.1
database_cross_reference: HPO:HP:0040068

Abnormality of lower limb bone
type: Class
subclass of: Abnormality of limb bone
MCID: MC01000886
PMOID: PMO:00002495
Subclass_of: Abnormality of limb bone
Tree Number: T3.5.1.1
database_cross_reference: HPO:HP:0040069

Abnormality of the lower limb
type: Class
subclass of: Abnormality of limbs
Definition: An abnormality of the leg.
MCID: MC00364616
PMOID: PMO:00002520
Subclass_of: Abnormality of limbs
Synonym: Abnormality of the leg
Synonym: Deformity of lower limb
Synonym: Deformity of lower limb (finding)
Synonym: EXTREMITY DEFORMITY, LOWER
Synonym: Hindlimb deformity
Synonym: LOWER EXTREMITY DEFORMITY
Synonym: Lower limb deformities
Synonym: Lower limb deformity
Tree Number: T3.5.2
database_cross_reference: CCPSS:0041695
database_cross_reference: DXP:U001221
database_cross_reference: HPO:HP:0002814
database_cross_reference: MDR:10053640
database_cross_reference: OMIM:MTHU006324
database_cross_reference: SNOMEDCT_US:449715001
database_cross_reference: SNOMEDCT_VET:310581000009104
database_cross_reference: SNOMEDCT_VET:449715001

Abnormality of lower limb epiphysis morphology
type: Class
subclass of: Abnormality of the lower limb
Definition: An anomaly of one or more epiphyses of one or both legs.
MCID: MC01000210
PMOID: PMO:00002521
Subclass_of: Abnormality of the lower limb
Synonym: Abnormal shape of end part of lower limb end bone
Synonym: Abnormality involving the epiphyses of the lower limbs
Tree Number: T3.5.2.1
database_cross_reference: HPO:HP:0006500

Abnormality of lower limb joint
type: Class
subclass of: Abnormality of the lower limb
MCID: MC00999738
PMOID: PMO:00002690
Subclass_of: Abnormality of the lower limb
Synonym: Abnormality of the joints of the lower limbs
Tree Number: T3.5.2.2
database_cross_reference: HPO:HP:0100491

Abnormality of the calf
type: Class
subclass of: Abnormality of the lower limb
Definition: An abnormality of the calf, i.e. of the posterior part of the lower leg.
MCID: MC01000379
PMOID: PMO:00002729
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.3
database_cross_reference: HPO:HP:0002981

Abnormality of the foot
type: Class
subclass of: Abnormality of the lower limb
Definition: An abnormality of the skeleton of foot.
MCID: MC00005246
PMOID: PMO:00002730
Subclass_of: Abnormality of the lower limb
Synonym: Abnormal feet morphology
Synonym: Abnormality of the feet
Synonym: Deformities, Foot
Synonym: Deformity of foot
Synonym: Deformity of foot (finding)
Synonym: Deformity, Foot
Synonym: FOOT DEFORMITY
Synonym: Foot Deformities
Synonym: Foot Deformities [Disease/Finding]
Synonym: Foot Deformity
Tree Number: T3.5.2.4
database_cross_reference: CHV:0000005189
database_cross_reference: DXP:U001562
database_cross_reference: HPO:HP:0001760
database_cross_reference: LCH_NW:sh85050353
database_cross_reference: MDR:10016966
database_cross_reference: MDR:10061159
database_cross_reference: MEDCIN:10738
database_cross_reference: MSH:D005530
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001272
database_cross_reference: OMIM:MTHU001017
database_cross_reference: OMIM:MTHU004518
database_cross_reference: RCD:Ub1oa
database_cross_reference: SNOMEDCT_US:229844004

Abnormality of the musculature of the lower limbs
type: Class
subclass of: Abnormality of the lower limb
MCID: MC01003056
PMOID: PMO:00002803
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.5
database_cross_reference: HPO:HP:0001437

Amniotic constriction rings of legs
type: Class
subclass of: Abnormality of the lower limb
Definition: Amniotic constriction rings affecting the legs.
MCID: MC01001638
PMOID: PMO:00002820
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.6
database_cross_reference: HPO:HP:0010495

Areflexia of lower limbs
type: Class
subclass of: Abnormality of the lower limb
Definition: Inability to elicit tendon reflexes in the lower limbs.
MCID: MC01396948
PMOID: PMO:00002821
Subclass_of: Abnormality of the lower limb
Synonym: Absent lower limb tendon reflexes
Synonym: Areflexia in lower limbs
Synonym: Areflexia of the lower limbs
Synonym: Areflexia, lower limbs
Tree Number: T3.5.2.7
database_cross_reference: HPO:HP:0002522

Externally rotated/abducted legs
type: Class
subclass of: Abnormality of the lower limb
MCID: MC01398255
PMOID: PMO:00002825
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.8
database_cross_reference: HPO:HP:0003783

Hypertrophy of the lower limb
type: Class
subclass of: Abnormality of the lower limb
Definition: Abnormal increase in size of the lower limbs (due to an increase of the size of cells).
MCID: MC01001637
PMOID: PMO:00002827
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.9
database_cross_reference: HPO:HP:0010496

Lower limb asymmetry
type: Class
subclass of: Abnormality of the lower limb
Definition: A difference in length or diameter between the left and right leg.
MCID: MC01399640
PMOID: PMO:00002828
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.10
database_cross_reference: HPO:HP:0100559

Rickets of the lower limbs
type: Class
subclass of: Abnormality of the lower limb
MCID: MC01400972
PMOID: PMO:00002829
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.11
database_cross_reference: HPO:HP:0006463

Sirenomelia
type: Class
subclass of: Abnormality of the lower limb
Definition: A developmental defect in which the legs are fused together.
MCID: MC00011899
PMOID: PMO:00002830
Subclass_of: Abnormality of the lower limb
Synonym: (Sirenomelia (& [mermaid] or [sympus])
Synonym: (Sirenomelia (& [mermaid] or [sympus]) (disorder)
Synonym: Fused Legs and Feet
Synonym: Malformation, Mermaid
Synonym: Mermaid Malformation
Synonym: Mermaid Syndrome
Synonym: Mermaid sirenomelia
Synonym: Mermaid sirenomelia (disorder)
Synonym: Mermaid syndrome
Synonym: SIRENOMELIA
Tree Number: T3.5.2.12
database_cross_reference: CHV:0000011373
database_cross_reference: HPO:HP:0010497
database_cross_reference: MDR:10049216
database_cross_reference: MDR:10072457
database_cross_reference: MDR:10072464
database_cross_reference: MSH:D004480
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118455
database_cross_reference: NCI_CDISC:C118455
database_cross_reference: NCI_NICHD:C118455
database_cross_reference: OMIM:600145
database_cross_reference: RCD:X77rt
database_cross_reference: RCD:XE2R4
database_cross_reference: SNM:M-28210
database_cross_reference: SNMI:D4-01561
database_cross_reference: SNMI:D4-F1110
database_cross_reference: SNOMEDCT_US:205815002
database_cross_reference: SNOMEDCT_US:253191000
database_cross_reference: SNOMEDCT_US:67254002
database_cross_reference: SNOMEDCT_US:91089008

Abnormality of the musculature of the limbs
type: Class
subclass of: Abnormality of limbs
MCID: MC01002296
PMOID: PMO:00002831
Subclass_of: Abnormality of limbs
Synonym: Abnormal limb muscles
Tree Number: T3.5.3
database_cross_reference: HPO:HP:0009127

Abnormality of the musculature of the upper limbs
type: Class
subclass of: Abnormality of the musculature of the limbs
MCID: MC01003051
PMOID: PMO:00002832
Subclass_of: Abnormality of the musculature of the limbs
Synonym: Abnormal upper limb muscles
Tree Number: T3.5.3.1
database_cross_reference: HPO:HP:0001446

Asymmetric limb muscle stiffness
type: Class
subclass of: Abnormality of the musculature of the limbs
Definition: Stiffness of the limbs (acondition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in an asymmetric pattern.
MCID: MC01002481
PMOID: PMO:00002850
Subclass_of: Abnormality of the musculature of the limbs
Tree Number: T3.5.3.2
database_cross_reference: HPO:HP:0007156

Generalized weakness of limb muscles
type: Class
subclass of: Abnormality of the musculature of the limbs
Definition: Generalized weakness of the muscles of the arms and legs.
MCID: MC01398530
PMOID: PMO:00002851
Subclass_of: Abnormality of the musculature of the limbs
Tree Number: T3.5.3.3
database_cross_reference: HPO:HP:0009028

Limb muscle weakness
type: Class
subclass of: Abnormality of the musculature of the limbs
Definition: Reduced strength and weakness of the muscles of the arms and legs.
MCID: MC01399511
PMOID: PMO:00002852
Subclass_of: Abnormality of the musculature of the limbs
Synonym: Limb weakness
Tree Number: T3.5.3.4
database_cross_reference: HPO:HP:0003690

Abnormality of the upper limb
type: Class
subclass of: Abnormality of limbs
Definition: An abnormality of the arm.
MCID: MC00999679
PMOID: PMO:00002860
Subclass_of: Abnormality of limbs
Synonym: Abnormality of the arm
Tree Number: T3.5.4
database_cross_reference: HPO:HP:0002817

Abnormal arm span
type: Class
subclass of: Abnormality of the upper limb
Definition: A deviation from normal of the length of the arm span (length from one end of an individual's arms (measured at the fingertips) to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle.
MCID: MC01001024
PMOID: PMO:00002861
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.1
database_cross_reference: HPO:HP:0012769

Abnormality of the forearm
type: Class
subclass of: Abnormality of the upper limb
Definition: An abnormality of the lower arm.
MCID: MC01002963
PMOID: PMO:00002864
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.2
database_cross_reference: HPO:HP:0002973

Abnormality of the hand
type: Class
subclass of: Abnormality of the upper limb
Definition: An abnormality affecting one or both hands.
MCID: MC00005937
PMOID: PMO:00002869
Subclass_of: Abnormality of the upper limb
Synonym: Abnormal hands
Synonym: Deformities, Hand
Synonym: Deformity of hand
Synonym: Deformity of hand (finding)
Synonym: Deformity, Hand
Synonym: HAND DEFORMITY
Synonym: Hand Deformities
Synonym: Hand Deformities [Disease/Finding]
Synonym: Hand Deformity
Synonym: Hand anomalies
Tree Number: T3.5.4.3
database_cross_reference: CCPSS:0058855
database_cross_reference: CHV:0000005790
database_cross_reference: HPO:HP:0001155
database_cross_reference: LCH_NW:sh85058616
database_cross_reference: MDR:10025526
database_cross_reference: MDR:10025527
database_cross_reference: MDR:10025529
database_cross_reference: MDR:10050557
database_cross_reference: MDR:10061194
database_cross_reference: MEDCIN:10207
database_cross_reference: MEDCIN:63220
database_cross_reference: MSH:D006226
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001407
database_cross_reference: OMIM:MTHU004517
database_cross_reference: OMIM:MTHU006016
database_cross_reference: RCD:Xa767
database_cross_reference: SNOMEDCT_US:299033004

Abnormality of the upper arm
type: Class
subclass of: Abnormality of the upper limb
MCID: MC01003048
PMOID: PMO:00003117
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.4
database_cross_reference: HPO:HP:0001454

Abnormality of upper limb bone
type: Class
subclass of: Abnormality of the upper limb
MCID: MC01000885
PMOID: PMO:00003120
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.5
database_cross_reference: HPO:HP:0040070

Abnormality of upper limb joint
type: Class
subclass of: Abnormality of the upper limb
MCID: MC01000047
PMOID: PMO:00003246
Subclass_of: Abnormality of the upper limb
Synonym: Abnormality of the joints of the upper limbs
Tree Number: T3.5.4.6
database_cross_reference: HPO:HP:0009810

Amniotic constriction rings of arms
type: Class
subclass of: Abnormality of the upper limb
Definition: Amniotic constriction rings affecting the arms.
MCID: MC01001643
PMOID: PMO:00003341
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.7
database_cross_reference: HPO:HP:0010483

Anomaly of the upper limb diaphyses
type: Class
subclass of: Abnormality of the upper limb
Definition: A structural abnormality of a diaphysis of the arm.
MCID: MC01000049
PMOID: PMO:00003342
Subclass_of: Abnormality of the upper limb
Synonym: Abnormality involving the diaphyses of the upper limbs
Synonym: Abnormality of shaft of long bone of the upper limbs
Synonym: Diaphyseal abnormality of the upper limbs
Tree Number: T3.5.4.8
database_cross_reference: HPO:HP:0009808

Aplasia/hypoplasia involving bones of the upper limbs
type: Class
subclass of: Abnormality of the upper limb
Definition: Absence (due to failure to form) or underdevelopment of the bones of the upper limbs.
MCID: MC01396808
PMOID: PMO:00003348
Subclass_of: Abnormality of the upper limb
Synonym: Absent/small bones of the upper limbs
Synonym: Absent/underdeveloped bones of the upper limbs
Tree Number: T3.5.4.9
database_cross_reference: HPO:HP:0006496

Duplication of bones involving the upper extremities
type: Class
subclass of: Abnormality of the upper limb
MCID: MC01002289
PMOID: PMO:00003397
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.10
database_cross_reference: HPO:HP:0009142

Hypertrophy of the upper limb
type: Class
subclass of: Abnormality of the upper limb
Definition: Abnormal increase in size of the upper limbs (due to an increase of the size of cells).
MCID: MC01398733
PMOID: PMO:00003445
Subclass_of: Abnormality of the upper limb
Synonym: Increased size of upper limb
Tree Number: T3.5.4.11
database_cross_reference: HPO:HP:0010484

Upper limb asymmetry
type: Class
subclass of: Abnormality of the upper limb
Definition: Difference in length or size between the right and left arm.
MCID: MC01000529
PMOID: PMO:00003446
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.12
database_cross_reference: HPO:HP:0100560

Aplasia/hypoplasia of the extremities
type: Class
subclass of: Abnormality of limbs
Definition: Absence (due to failure to form) or underdevelopment of the extremities.
MCID: MC01396858
PMOID: PMO:00003448
Subclass_of: Abnormality of limbs
Synonym: Absent/small extremities
Synonym: Absent/underdeveloped extremities
Synonym: Short or absent limbs
Synonym: Shortened limbs
Tree Number: T3.5.5
database_cross_reference: HPO:HP:0009815

Acromelia
type: Class
subclass of: Aplasia/hypoplasia of the extremities
Definition: Shortening of the extremities affecting primarily the distal parts of the limbs (hands and feet) in relation to the other segments of the limbs.
MCID: MC01001563
PMOID: PMO:00003449
Subclass_of: Aplasia/hypoplasia of the extremities
Tree Number: T3.5.5.1
database_cross_reference: HPO:HP:0010884

Amelia
type: Class
subclass of: Aplasia/hypoplasia of the extremities
Definition: Congenital absence (aplasia) of one or more limbs.
MCID: MC00000706
PMOID: PMO:00003451
Subclass_of: Aplasia/hypoplasia of the extremities
Synonym: AMELIA
Synonym: Amelia (disorder)
Synonym: Amelia NOS
Synonym: Amelia of unspecified limb
Synonym: Amelia of unspecified limb (disorder)
Synonym: Amelia, NOS
Synonym: Congenital absence of limb
Synonym: Congenital absence of limb NOS
Synonym: Congenital absence of limb NOS (disorder)
Synonym: Congenital absence of limb, NOS
Tree Number: T3.5.5.2
database_cross_reference: CHV:0000000985
database_cross_reference: CST:ECTROMELIA
database_cross_reference: HPO:HP:0009827
database_cross_reference: ICD10:Q73.0
database_cross_reference: ICD10AM:Q73.0
database_cross_reference: ICD10CM:Q73.0
database_cross_reference: MDR:10001926
database_cross_reference: MSH:D004480
database_cross_reference: MTHICD9:755.4
database_cross_reference: NCI:C34370
database_cross_reference: NCI_NICHD:C34370
database_cross_reference: RCD:PF40.
database_cross_reference: RCD:PF41.
database_cross_reference: SNM:M-21010
database_cross_reference: SNMI:D4-12102
database_cross_reference: SNOMEDCT_US:205236007
database_cross_reference: SNOMEDCT_US:205238008
database_cross_reference: SNOMEDCT_US:62588002

Limb undergrowth
type: Class
subclass of: Aplasia/hypoplasia of the extremities
Definition: Limb shortening because of underdevelopment of one or more bones of the extremities.
MCID: MC01399513
PMOID: PMO:00003454
Subclass_of: Aplasia/hypoplasia of the extremities
Synonym: Hypoplasia involving bones of the extremities
Synonym: Short limb
Synonym: Short limbs
Synonym: limb shortening
Tree Number: T3.5.5.3
database_cross_reference: HPO:HP:0009826

Peromelia
type: Class
subclass of: Aplasia/hypoplasia of the extremities
Definition: The distal parts of the limbs are missing leading to a stump formation.
MCID: MC01001959
PMOID: PMO:00003466
Subclass_of: Aplasia/hypoplasia of the extremities
Tree Number: T3.5.5.4
database_cross_reference: HPO:HP:0009828

Autoamputation
type: Class
subclass of: Abnormality of limbs
Definition: Spontaneous detachment (amputation) of an appendage from the body.
MCID: MC01396997
PMOID: PMO:00003467
Subclass_of: Abnormality of limbs
Tree Number: T3.5.6
database_cross_reference: HPO:HP:0001218

Autoamputation of digits
type: Class
subclass of: Autoamputation
MCID: MC01396998
PMOID: PMO:00003468
Subclass_of: Autoamputation
Tree Number: T3.5.6.1
database_cross_reference: HPO:HP:0007460

Autoamputation of foot
type: Class
subclass of: Autoamputation
Definition: Spontaneous detachment of a foot from the body.
MCID: MC01396999
PMOID: PMO:00003470
Subclass_of: Autoamputation
Tree Number: T3.5.6.2
database_cross_reference: HPO:HP:0001868

Hemihypertrophy
type: Class
subclass of: Abnormality of limbs
Definition: Overgrowth of only one side of the body.
MCID: MC00115991
PMOID: PMO:00003471
Subclass_of: Abnormality of limbs
Synonym: Asymmetric limb hypertrophy
Synonym: Congenital hemihypertrophy
Synonym: Congenital hemihypertrophy (disorder)
Synonym: Congenital hemihypertrophy (morphologic abnormality)
Synonym: HEMIHYPERTROPHY
Synonym: Hemi-hypertrophy
Synonym: Hemihyperplasia
Synonym: Hemihypertrophy, congenital
Synonym: congenital hemihypertrophy
Synonym: congenital hemihypertrophy (diagnosis)
Tree Number: T3.5.7
database_cross_reference: CHV:0000029578
database_cross_reference: CST:HYPERTROPHY
database_cross_reference: HPO:HP:0001528
database_cross_reference: MDR:10019463
database_cross_reference: MEDCIN:313612
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C88541
database_cross_reference: NCI_NCI-GLOSS:CDR0000482352
database_cross_reference: NCI_NICHD:C88541
database_cross_reference: OMIM:MTHU015904
database_cross_reference: OMIM:MTHU017558
database_cross_reference: RCD:PKyz6
database_cross_reference: SNM:M-20550
database_cross_reference: SNMI:M-20510
database_cross_reference: SNOMEDCT_US:205838004
database_cross_reference: SNOMEDCT_US:56007004

Hemihypertrophy of lower limb
type: Class
subclass of: Hemihypertrophy
Definition: Overgrowth of only one leg.
MCID: MC00145985
PMOID: PMO:00003472
Subclass_of: Hemihypertrophy
Synonym: Congen overgrowth lower limb
Synonym: Congenital overgrowth of lower limb
Synonym: Congenital overgrowth of lower limb (disorder)
Synonym: Overgrowth of one leg
Tree Number: T3.5.7.1
database_cross_reference: HPO:HP:0100553
database_cross_reference: RCD:PF6B.
database_cross_reference: SNOMEDCT_US:205369009

Hemihypertrophy of upper limb
type: Class
subclass of: Hemihypertrophy
Definition: Overgrowth of only one arm.
MCID: MC00145885
PMOID: PMO:00003473
Subclass_of: Hemihypertrophy
Synonym: Overgrowth of one arm
Synonym: Overgrowth of upper limb
Synonym: Overgrowth of upper limb (disorder)
Tree Number: T3.5.7.2
database_cross_reference: HPO:HP:0100554
database_cross_reference: RCD:X786j
database_cross_reference: SNOMEDCT_US:253920006

Abnormality of metabolism/homeostasis
type: Class
subclass of: Phenotypic Abnormality
MCID: MC01396324
PMOID: PMO:00003474
Subclass_of: Phenotypic Abnormality
Synonym: Laboratory abnormality
Synonym: Metabolism abnormality
Tree Number: T3.6
database_cross_reference: HPO:HP:0001939

5-oxoprolinase deficiency
type: Class
subclass of: Abnormality of metabolism/homeostasis
MCID: MC00092813
PMOID: PMO:00003475
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: 5-@OXOPROLINASE DEFICIENCY
Synonym: 5-OXOPROLINASE DEFICIENCY
Synonym: 5-Oxoprolinase deficiency
Synonym: 5-Oxoprolinase deficiency (disorder)
Synonym: 5-alpha-oxoprolinase deficiency
Synonym: OPLAHD
Synonym: OXOPROLINURIA DUE TO 5-OXOPROLINASE DEFICIENCY
Synonym: Oxoprolinuria Due To Oxoprolinase Deficiency
Synonym: Oxoprolinuria due to 5-oxoprolinase deficiency
Synonym: Pyroglutamate hydrolase deficiency
Tree Number: T3.6.1
database_cross_reference: HPO:HP:0040142
database_cross_reference: MSH:C535322
database_cross_reference: OMIM:260005
database_cross_reference: OMIM:614243
database_cross_reference: OMIM:MTHU037864
database_cross_reference: RCD:Xa6b1
database_cross_reference: SNMI:D6-A3570
database_cross_reference: SNOMEDCT_US:26132002

Abnormal cellular physiology
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality in a cellular process.
PMOID: PMO:00003476
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.2

Abnormal cell proliferation
type: Class
subclass of: Abnormal cellular physiology
Definition: Any abnormality in the multiplication or reproduction of cells, which may result in the expansion of a cell population.
MCID: MC01395802
PMOID: PMO:00003477
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.1
database_cross_reference: HPO:HP:0031377

Abnormality of chromosome condensation
type: Class
subclass of: Abnormal cellular physiology
Definition: An abnormality of chromosome condensation.
MCID: MC01396259
PMOID: PMO:00003478
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.2
database_cross_reference: HPO:HP:0011019

Abnormality of chromosome segregation
type: Class
subclass of: Abnormal cellular physiology
Definition: An abnormality of chromosome segregation.
MCID: MC01396260
PMOID: PMO:00003480
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.3
database_cross_reference: HPO:HP:0002916

Abnormality of chromosome stability
type: Class
subclass of: Abnormal cellular physiology
Definition: A type of chromosomal aberration reduced resistance of chromosomes to change or deterioration.
MCID: MC00133391
PMOID: PMO:00003484
Subclass_of: Abnormal cellular physiology
Synonym: Breakage, Chromosomal
Synonym: Breakage, Chromosome
Synonym: Breakages, Chromosomal
Synonym: Breakages, Chromosome
Synonym: Chromosomal Breakage
Synonym: Chromosomal Breakages
Synonym: Chromosome Breakage
Synonym: Chromosome Breakage [Disease/Finding]
Synonym: Chromosome Breakages
Synonym: Chromosome breakage
Tree Number: T3.6.2.4
database_cross_reference: GO:GO:0031052
database_cross_reference: HPO:HP:0003220
database_cross_reference: HPO:HP:0040012
database_cross_reference: LNC:LP32790-5
database_cross_reference: LNC:MTHU016278
database_cross_reference: MSH:D019457
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85870
database_cross_reference: NDFRT:N0000003925
database_cross_reference: OMIM:MTHU049773

Abnormality of DNA repair
type: Class
subclass of: Abnormal cellular physiology
Definition: An abnormality of the process of DNA repair, that is, of the process of restoring DNA after damage.
MCID: MC01000389
PMOID: PMO:00003490
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.5
database_cross_reference: HPO:HP:0003254

Abnormality of lysosomal metabolism
type: Class
subclass of: Abnormal cellular physiology
MCID: MC01396320
PMOID: PMO:00003493
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.6
database_cross_reference: HPO:HP:0004356

Abnormality of redox activity
type: Class
subclass of: Abnormal cellular physiology
Definition: An abnormality of the processes that maintain the redox environment of a cell or compartment within a cell, that is, the balance between reduction and oxidation chemical reactions.
MCID: MC01396355
PMOID: PMO:00003498
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.7
database_cross_reference: HPO:HP:0025463

Abnormality of the cell cycle
type: Class
subclass of: Abnormal cellular physiology
Definition: An abnormality of the cell cycle.
MCID: MC01001530
PMOID: PMO:00003500
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.8
database_cross_reference: HPO:HP:0011018

Abnormality of the mitochondrion
type: Class
subclass of: Abnormal cellular physiology
Definition: An anomaly of the mitochondrion, the membranous cytoplasmic organelle the interior of which is subdivided by cristae. The mitochondrion is a self replicating organelle that is the site of tissue respiration.
MCID: MC01001180
PMOID: PMO:00003502
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.9
database_cross_reference: HPO:HP:0012103

Increased cellular sensitivity to UV light
type: Class
subclass of: Abnormal cellular physiology
MCID: MC01399031
PMOID: PMO:00003529
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.10
database_cross_reference: HPO:HP:0003224

Increased sensitivity to ionizing radiation
type: Class
subclass of: Abnormal cellular physiology
Definition: An abnormally increased sensitivity to the effects of ionizing radiation.
MCID: MC01399195
PMOID: PMO:00003530
Subclass_of: Abnormal cellular physiology
Synonym: Increased sensitivity to ionising radiation
Tree Number: T3.6.2.11
database_cross_reference: HPO:HP:0011133

Intracellular accumulation of autofluorescent lipopigment storage material
type: Class
subclass of: Abnormal cellular physiology
Definition: The intracellular accumulation of autofluorescent storage material.
MCID: MC01399334
PMOID: PMO:00003531
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.12
database_cross_reference: HPO:HP:0003204

Abnormal enzyme/coenzyme activity
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An altered ability of any enzyme or their cofactors to act as catalysts. This term includes changes due to altered levels of an enzyme.
MCID: MC01395876
PMOID: PMO:00003536
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.3
database_cross_reference: HPO:HP:0012379

Abnormal aldolase level
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: An abnormal concentration of aldolase in the serum. Aldolase is an enzyme responsible for converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate.
MCID: MC01395738
PMOID: PMO:00003537
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.1
database_cross_reference: HPO:HP:0012400

Abnormal biotinidase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: An abnormality in biotinidase activity, an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation.
MCID: MC01395765
PMOID: PMO:00003540
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.2
database_cross_reference: HPO:HP:0410144

Abnormal hypoxanthine-guanine phosphoribosyltransferase level
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: Altered level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.
MCID: MC01395934
PMOID: PMO:00003543
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Abnormal 6-hydroxypurine phosphoribosyltransferase level
Synonym: Abnormal GMP pyrophosphorylase level
Synonym: Abnormal GPRT level
Tree Number: T3.6.3.3
database_cross_reference: HPO:HP:0031821

Abnormal lactate dehydrogenase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate.
MCID: MC01395953
PMOID: PMO:00003546
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.4
database_cross_reference: HPO:HP:0045040

Abnormal serum mast cell beta-tryptase concentration
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: Any deviation from the normal circulating concentration of mast cell beta-tryptase concentration.
MCID: MC01396133
PMOID: PMO:00003549
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.5
database_cross_reference: HPO:HP:0031900

Abnormal superoxide dismutase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: An abnormal level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
MCID: MC01396161
PMOID: PMO:00003552
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Abnormal superoxide:superoxide oxidoreductase activity
Tree Number: T3.6.3.6
database_cross_reference: HPO:HP:0031835

Abnormal uridine diphosphate glucose-4-epimerase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: An abnormality in uridine diphosphate glucose-4-epimerase activity, an enzyme that catalyzes the reaction: UDP-glucose = UDP-galactose.
MCID: MC01396192
PMOID: PMO:00003555
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Abnormal UDP-glucose 4-epimerase activity activity
Tree Number: T3.6.3.7
database_cross_reference: HPO:HP:0410192

Abnormality of alkaline phosphatase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: An abnormality of alkaline phosphatase activity.
MCID: MC01396230
PMOID: PMO:00003562
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.8
database_cross_reference: HPO:HP:0004379

Decreased lecithin cholesterol acyl transferase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: Reduced activity of the enzyme lecithin cholesterol acyl transferase.
MCID: MC01397582
PMOID: PMO:00003580
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.9
database_cross_reference: HPO:HP:0025433

Decreased lipoprotein lipase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: Reduction in the activity of lipoprotein lipase in the blood.
MCID: MC01397597
PMOID: PMO:00003581
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.10
database_cross_reference: HPO:HP:0031209

Decreased small intestinal mucosa lactase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: Lactase is produced in the small intestine in humans, Lactase is a member of the beta-galactosidase family of enzymes, and hydrolyzes D-lactose to form D-galactose and D-glucose, which can be absorbed by the small intestine. There are many ways of assessing lactase activity. In one test, an endoscopic biopsy from the postbulbar duodenum is incubated with lactose on a test plate, and a color reaction develops within 20 min as a result of hydrolyzed lactose (a positive result) in patients with normolactasia, whereas no reaction (a negative result) develops in patients with severe hypolactasia. Other, less direct, tests include the hydrogen breath test, and blood tests following lactose challenges.
MCID: MC01397684
PMOID: PMO:00003582
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Lactase deficiency
Tree Number: T3.6.3.11
database_cross_reference: HPO:HP:0025130

Elevated gamma-glutamyltransferase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: Increased activity of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.
MCID: MC01398062
PMOID: PMO:00003583
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.12
database_cross_reference: HPO:HP:0030948

Platelet-activating factor acetylhydrolase deficiency
type: Class
subclass of: Abnormal enzyme/coenzyme activity
MCID: MC00895237
PMOID: PMO:00003584
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: PAFAD
Synonym: PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE DEFICIENCY
Synonym: Platelet-Activating Factor Acetylhydrolase Deficiency
Tree Number: T3.6.3.13
database_cross_reference: HPO:HP:0040175
database_cross_reference: MSH:C566640
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:601690
database_cross_reference: OMIM:614278

Reduced carnitine O-palmitoyltransferase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: Reduced carnitine O-palmitoyltransferase activity, i.e., reduced activity of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.
MCID: MC01400806
PMOID: PMO:00003585
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.14
database_cross_reference: HPO:HP:0012380

Reduced catalase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: An abnormally decreased amount of catalase activity.
MCID: MC01400807
PMOID: PMO:00003586
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.15
database_cross_reference: HPO:HP:0012517

Reduced lysosomal acid lipase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
Definition: Reduction in the activity of lysosomal acid lipase (LAL) in the blood. Lysosomal lipase activity is measured. LAL hydrolyzes cholesteryl esters derived from cell internalization of plasma lipoproteins.
MCID: MC01400837
PMOID: PMO:00003587
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Reduced leukocyte acid lipase activity
Tree Number: T3.6.3.16
database_cross_reference: HPO:HP:0031205

Abnormal erythrocyte sedimentation rate
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: A deviation from normal range of the erythrocyte sedimentation rate (ESR), a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.
MCID: MC01395880
PMOID: PMO:00003588
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Abnormal ESR
Synonym: Abnormal Westergren sedimentation rate
Tree Number: T3.6.4
database_cross_reference: HPO:HP:0025021

Decreased erythrocyte sedimentation rate
type: Class
subclass of: Abnormal erythrocyte sedimentation rate
Definition: A reduced erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.
MCID: MC01397549
PMOID: PMO:00003589
Subclass_of: Abnormal erythrocyte sedimentation rate
Synonym: Low ESR
Tree Number: T3.6.4.1
database_cross_reference: HPO:HP:0025022

Elevated erythrocyte sedimentation rate
type: Class
subclass of: Abnormal erythrocyte sedimentation rate
Definition: An increased erythrocyte sedimentation rate (ESR). The ESR a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.
MCID: MC01398061
PMOID: PMO:00003590
Subclass_of: Abnormal erythrocyte sedimentation rate
Synonym: Elevated sedimentation rate
Synonym: High ESR
Synonym: High erythrocyte sedimentation rate
Synonym: Increased erythrocyte sedimentation rate
Synonym: Raised erythrocyte sedimentation rate
Tree Number: T3.6.4.2
database_cross_reference: HPO:HP:0003565

Abnormal homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An anomaly in the processes involved in the maintenance of an internal equilibrium.
MCID: MC01395928
PMOID: PMO:00003591
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.5
database_cross_reference: HPO:HP:0012337

Abnormal energy expenditure
type: Class
subclass of: Abnormal homeostasis
Definition: Any anomaly in the utilization of energy (calories).
MCID: MC01395875
PMOID: PMO:00003592
Subclass_of: Abnormal homeostasis
Tree Number: T3.6.5.1
database_cross_reference: HPO:HP:0012338

Abnormal serum selenium concentration
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: Any deviation from the normal circulating concentration of selenium.
MCID: MC01396134
PMOID: PMO:00003595
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.6
database_cross_reference: HPO:HP:0031903

Abnormal sweat homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality of the composition of sweat or the levels of its components.
MCID: MC01396163
PMOID: PMO:00003596
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.7
database_cross_reference: HPO:HP:0040127

Abnormal sweat electrolytes
type: Class
subclass of: Abnormal sweat homeostasis
MCID: MC01396162
PMOID: PMO:00003597
Subclass_of: Abnormal sweat homeostasis
Tree Number: T3.6.7.1
database_cross_reference: HPO:HP:0040128

Abnormality of acid-base homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH.
MCID: MC01396228
PMOID: PMO:00003598
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.8
database_cross_reference: HPO:HP:0004360

Abnormal serum anion gap
type: Class
subclass of: Abnormality of acid-base homeostasis
Definition: Any deviation from the normal value of the serum anion gap, which is calculated from the electrolytes measured in the chemical laboratory, is defined as the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration.
MCID: MC01396120
PMOID: PMO:00003599
Subclass_of: Abnormality of acid-base homeostasis
Tree Number: T3.6.8.1
database_cross_reference: HPO:HP:0031961

Abnormal serum bicarbonate concentration
type: Class
subclass of: Abnormality of acid-base homeostasis
Definition: Any deviation from the normal concentration of bicarbonate, HCO3[-], in the circulation.
MCID: MC01396121
PMOID: PMO:00003602
Subclass_of: Abnormality of acid-base homeostasis
Tree Number: T3.6.8.2
database_cross_reference: HPO:HP:0032065

Acidosis
type: Class
subclass of: Abnormality of acid-base homeostasis
Definition: Abnormal acid accumulation or depletion of base.
MCID: MC00000240
PMOID: PMO:00003605
Subclass_of: Abnormality of acid-base homeostasis
Synonym: ACIDOSIS
Synonym: Acidoses
Synonym: Acidosis (disorder)
Synonym: Acidosis NOS
Synonym: Acidosis NOS (disorder)
Synonym: Acidosis [Disease/Finding]
Synonym: Acidosis, NOS
Synonym: acidemia
Synonym: acidoses
Synonym: acidosis
Tree Number: T3.6.8.3
database_cross_reference: AOD:0000005821
database_cross_reference: CCPSS:0063443
database_cross_reference: CHV:0000000634
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0465-0952
database_cross_reference: CST:ACIDOSIS
database_cross_reference: CST:METACIDOSIS
database_cross_reference: DXP:U000077
database_cross_reference: HPO:HP:0001941
database_cross_reference: ICD10:E87.2
database_cross_reference: ICD10AM:E87.2
database_cross_reference: ICD10CM:E87.2
database_cross_reference: ICD9CM:276.2
database_cross_reference: LCH:U000036
database_cross_reference: LCH_NW:sh85000531
database_cross_reference: MDR:10000486
database_cross_reference: MDR:10000493
database_cross_reference: MEDCIN:338589
database_cross_reference: MSH:D000138
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000118
database_cross_reference: MTHICD9:276.2
database_cross_reference: NCI:C83504
database_cross_reference: NDFRT:N0000000283
database_cross_reference: RCD:C362.
database_cross_reference: RCD:C362z
database_cross_reference: SNMI:D6-23100
database_cross_reference: SNOMEDCT_US:154757004
database_cross_reference: SNOMEDCT_US:190887001
database_cross_reference: SNOMEDCT_US:51387008

Alkalosis
type: Class
subclass of: Abnormality of acid-base homeostasis
Definition: Depletion of acid or accumulation base in the body fluids.
MCID: MC00000561
PMOID: PMO:00003630
Subclass_of: Abnormality of acid-base homeostasis
Synonym: ALKALOSIS
Synonym: Alkaloses
Synonym: Alkalosis (disorder)
Synonym: Alkalosis NOS
Synonym: Alkalosis NOS (disorder)
Synonym: Alkalosis [Disease/Finding]
Synonym: Alkalosis, NOS
Synonym: alkaloses
Synonym: alkalosis
Synonym: alkalosis (diagnosis)
Tree Number: T3.6.8.4
database_cross_reference: AOD:0000005830
database_cross_reference: CCPSS:1007046
database_cross_reference: CHV:0000000900
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0465-1418
database_cross_reference: CST:ALKALOSIS
database_cross_reference: CST:METALKALOSIS
database_cross_reference: DXP:U000131
database_cross_reference: HPO:HP:0001948
database_cross_reference: ICD10:E87.3
database_cross_reference: ICD10AM:E87.3
database_cross_reference: ICD10CM:E87.3
database_cross_reference: ICD9CM:276.3
database_cross_reference: LCH:U000148
database_cross_reference: LCH_NW:sh85003603
database_cross_reference: MDR:10001680
database_cross_reference: MDR:10001687
database_cross_reference: MEDCIN:338591
database_cross_reference: MSH:D000471
database_cross_reference: MTH:U000119
database_cross_reference: MTHICD9:276.3
database_cross_reference: NCI:C37909
database_cross_reference: NCI_CTCAE:E12247
database_cross_reference: NDFRT:N0000000355
database_cross_reference: OMIM:MTHU054076
database_cross_reference: RCD:C363.
database_cross_reference: RCD:C363z
database_cross_reference: SNMI:D6-24000
database_cross_reference: SNOMEDCT_US:154758009
database_cross_reference: SNOMEDCT_US:190892004
database_cross_reference: SNOMEDCT_US:21420006

Abnormality of calcium-phosphate metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
MCID: MC01396247
PMOID: PMO:00003637
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.9
database_cross_reference: HPO:HP:0100530

Decreased circulating parathyroid hormone level
type: Class
subclass of: Abnormality of calcium-phosphate metabolism
Definition: An abnormally decreased concentration of parathyroid hormone.
MCID: MC01397532
PMOID: PMO:00003638
Subclass_of: Abnormality of calcium-phosphate metabolism
Synonym: Decreased circulating PTH level
Synonym: Decreased serum PTH
Synonym: Decreased serum parathyroid hormone
Synonym: Decreased serum parathyroid hormone level
Tree Number: T3.6.9.1
database_cross_reference: HPO:HP:0031817

Elevated calcitonin
type: Class
subclass of: Abnormality of calcium-phosphate metabolism
MCID: MC01398042
PMOID: PMO:00003639
Subclass_of: Abnormality of calcium-phosphate metabolism
Tree Number: T3.6.9.2
database_cross_reference: HPO:HP:0003528

Elevated circulating parathyroid hormone level
type: Class
subclass of: Abnormality of calcium-phosphate metabolism
Definition: An abnormal increased concentration of parathyroid hormone.
MCID: MC01398051
PMOID: PMO:00003640
Subclass_of: Abnormality of calcium-phosphate metabolism
Synonym: Elevated circulating PTH level
Synonym: Elevated serum parathyroid hormone
Synonym: Elevated serum parathyroid hormone level
Synonym: Elevated serum pth
Synonym: Increased serum parathyroid hormone
Tree Number: T3.6.9.3
database_cross_reference: HPO:HP:0003165

Abnormality of carbohydrate metabolism/homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality of the metabolism/homeostasis of a carbohydrate.
MCID: MC01396248
PMOID: PMO:00003641
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.10
database_cross_reference: HPO:HP:0011013

Abnormal circulating glycerol level
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: Any deviation from the normal concentration of glycerol in the blood.
MCID: MC01395821
PMOID: PMO:00003642
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.1
database_cross_reference: HPO:HP:0031795

Abnormal glucose homeostasis
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: Abnormality of glucose homeostasis.
MCID: MC01395905
PMOID: PMO:00003645
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.2
database_cross_reference: HPO:HP:0011014

Abnormal glucose-6-phosphate dehydrogenase level
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An anomaly in the level of glucose-6-phosphate dehydrogenase.
MCID: MC01395907
PMOID: PMO:00003674
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Abnormal G6PD level
Tree Number: T3.6.10.3
database_cross_reference: HPO:HP:0410176

Abnormal glycosylation
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An anomaly of a glycosylation process, i.e., a process involved in the covalent attachment of a glycosyl residue to a substrate molecule.
MCID: MC01395913
PMOID: PMO:00003690
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.4
database_cross_reference: HPO:HP:0012345

Abnormality of glycolysis
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An abnormality of glycolysis.
MCID: MC01396298
PMOID: PMO:00003712
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.5
database_cross_reference: HPO:HP:0004366

Abnormality of glycoside metabolism
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: Abnormality of glycoside metabolism.
MCID: MC01396301
PMOID: PMO:00003715
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.6
database_cross_reference: HPO:HP:0003649

Abnormality of polysaccharide metabolism
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An abnormality of the metabolism of polysaccharide.
MCID: MC01396345
PMOID: PMO:00003718
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.7
database_cross_reference: HPO:HP:0011012

Decreased level of 1,5 anhydroglucitol in serum
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: A decrease in the level of 1,5 anhydroglucitol in the serum. 1,5-Anhydrosorbitol is a validated marker of short-term glycemic control. This substance is derived mainly from food, is well absorbed in the intestine, and is distributed to all organs and tissues.
MCID: MC01397583
PMOID: PMO:00003730
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Decreased level of 1,5-AG in serum
Synonym: Decreased level of 1,5-anhydro-D-glucitol in serum
Synonym: Decreased level of 1,5-anhydroglucitol in serum
Tree Number: T3.6.10.8
database_cross_reference: HPO:HP:0410050

Decreased level of D-mannose in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: A decrease in the level of D-mannose in the urine.
MCID: MC01397585
PMOID: PMO:00003731
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.9
database_cross_reference: HPO:HP:0410060

Decreased level of erythritol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: A decrease in the level of erythritol in the urine.
MCID: MC01397587
PMOID: PMO:00003732
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.10
database_cross_reference: HPO:HP:0410055

Elevated circulating ribitol concentration
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase above the normal concentration of ribitol in the blood.
MCID: MC01398052
PMOID: PMO:00003733
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of ribitol in serum
Tree Number: T3.6.10.11
database_cross_reference: HPO:HP:0025550

Glycopeptiduria
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: Increased excretion of glycopeptides in the urine. Glycopeptides are peptides with carbohydrate moieties covalently attached to the side chains of the amino acid residues.
MCID: MC01398550
PMOID: PMO:00003734
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: High urine glycopeptide levels
Tree Number: T3.6.10.12
database_cross_reference: HPO:HP:0012067

Glyoxalase deficiency
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
MCID: MC01398552
PMOID: PMO:00003737
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.13
database_cross_reference: HPO:HP:0003258

Impairment of fructose metabolism
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An impairment of a fructose metabolic process.
MCID: MC01398971
PMOID: PMO:00003738
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.14
database_cross_reference: HPO:HP:0011033

Impairment of galactose metabolism
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An impairment of galactose metabolism.
MCID: MC01398972
PMOID: PMO:00003740
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Impaired galactose metabolism
Tree Number: T3.6.10.15
database_cross_reference: HPO:HP:0004915

Increased level of D-threitol in CSF
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of D-threitol in the cerebrospinal fluid.
MCID: MC01399110
PMOID: PMO:00003744
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of D-threitol in cerebrospinal fluid
Tree Number: T3.6.10.16
database_cross_reference: HPO:HP:0410058

Increased level of D-threitol in plasma
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of D-threitol in the plasma.
MCID: MC01399111
PMOID: PMO:00003745
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.17
database_cross_reference: HPO:HP:0410057

Increased level of D-threitol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of D-threitol in the urine.
MCID: MC01399112
PMOID: PMO:00003746
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.18
database_cross_reference: HPO:HP:0410059

Increased level of galactitol in plasma
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of galactitol in the plasma.
MCID: MC01399114
PMOID: PMO:00003747
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.19
database_cross_reference: HPO:HP:0410061

Increased level of galactitol in red blood cells
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of galactitol in the red blood cells.
MCID: MC01399115
PMOID: PMO:00003748
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of galactitol in erythrocytes
Tree Number: T3.6.10.20
database_cross_reference: HPO:HP:0410064

Increased level of galactitol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of galactitol in the urine.
MCID: MC01399116
PMOID: PMO:00003749
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.21
database_cross_reference: HPO:HP:0410062

Increased level of L-fucose in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of L-fucose in the urine.
MCID: MC01399120
PMOID: PMO:00003750
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.22
database_cross_reference: HPO:HP:0410067

Increased level of N-acetylneuraminic acid in fibroblasts
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of N-acetylneuraminic acid in cultured fibroblasts.
MCID: MC01399125
PMOID: PMO:00003751
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of NANA in fibroblasts
Synonym: Increased level of Neu5Ac in fibroblasts
Synonym: Increased level of sialic acid in fibroblasts
Tree Number: T3.6.10.23
database_cross_reference: HPO:HP:0410157

Increased level of N-acetylneuraminic acid in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of N-acetylneuraminic acid in the urine.
MCID: MC01399126
PMOID: PMO:00003752
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of NANA in urine
Synonym: Increased level of Neu5Ac in urine
Tree Number: T3.6.10.24
database_cross_reference: HPO:HP:0410156

Increased level of ribitol in CSF
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of ribitol in the cerebral spinal fluid.
MCID: MC01399130
PMOID: PMO:00003753
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of ribitol in cerebrospinal fluid
Tree Number: T3.6.10.25
database_cross_reference: HPO:HP:0410071

Increased level of ribitol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of ribitol in the urine.
MCID: MC01399131
PMOID: PMO:00003754
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.26
database_cross_reference: HPO:HP:0410070

Increased level of ribose in CSF
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of ribose in the cerebrospinal fluid.
MCID: MC01399132
PMOID: PMO:00003755
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of ribose in cerebrospinal fluid
Tree Number: T3.6.10.27
database_cross_reference: HPO:HP:0410073

Increased level of ribose in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of ribose in the urine.
MCID: MC01399133
PMOID: PMO:00003756
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.28
database_cross_reference: HPO:HP:0410072

Increased level of xylitol in CSF
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of xylitol in the cerebrospinal fluid.
MCID: MC01399134
PMOID: PMO:00003757
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of xylitol in cerebrospinal fluid
Tree Number: T3.6.10.29
database_cross_reference: HPO:HP:0410075

Increased level of xylitol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increase in the level of xylitol in the urine.
MCID: MC01399135
PMOID: PMO:00003758
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.30
database_cross_reference: HPO:HP:0410074

Increased urinary sedoheptulose
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: An increased concentration of sedoheptulose in the urine. Sedoheptulose is a monosaccharide with seven carbon atoms and a ketone functional group.
MCID: MC01399249
PMOID: PMO:00003759
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.31
database_cross_reference: HPO:HP:0025157

Oligosacchariduria
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
Definition: Increased urinary excretion of oligosaccharides (low molecular weight carbohydrate chains composed of at least three monosaccharide subunits), derived from a partial degradation of glycoproteins.
MCID: MC01400138
PMOID: PMO:00003760
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.32
database_cross_reference: HPO:HP:0010471

Abnormality of carboxylic acid metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality of the metabolism of a carboxylic acid.
MCID: MC01396249
PMOID: PMO:00003763
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.11
database_cross_reference: HPO:HP:0004354

Abnormality of amino acid metabolism
type: Class
subclass of: Abnormality of carboxylic acid metabolism
Definition: Abnormality of an amino acid metabolic process.
MCID: MC01396231
PMOID: PMO:00003764
Subclass_of: Abnormality of carboxylic acid metabolism
Tree Number: T3.6.11.1
database_cross_reference: HPO:HP:0004337

Abnormality of dicarboxylic acid metabolism
type: Class
subclass of: Abnormality of carboxylic acid metabolism
Definition: An abnormality of dicarboxylic acid metabolism.
MCID: MC01396276
PMOID: PMO:00003894
Subclass_of: Abnormality of carboxylic acid metabolism
Tree Number: T3.6.11.2
database_cross_reference: HPO:HP:0010995

Abnormality of monocarboxylic acid metabolism
type: Class
subclass of: Abnormality of carboxylic acid metabolism
Definition: An abnormality of monocarboxylic acid metabolism.
MCID: MC01396327
PMOID: PMO:00003900
Subclass_of: Abnormality of carboxylic acid metabolism
Tree Number: T3.6.11.3
database_cross_reference: HPO:HP:0010996

Aldehyde oxidase deficiency
type: Class
subclass of: Abnormality of carboxylic acid metabolism
Definition: A reduction in aldehyde oxidase activity.
MCID: MC00437106
PMOID: PMO:00003911
Subclass_of: Abnormality of carboxylic acid metabolism
Synonym: Deficiency of aldehyde oxidase
Synonym: Deficiency of aldehyde oxidase (disorder)
Tree Number: T3.6.11.4
database_cross_reference: HPO:HP:0002932
database_cross_reference: SNOMEDCT_US:124161002

Increased level of galactonate in red blood cells
type: Class
subclass of: Abnormality of carboxylic acid metabolism
Definition: An increase in the level of galactonate in the red blood cells.
MCID: MC01399117
PMOID: PMO:00003912
Subclass_of: Abnormality of carboxylic acid metabolism
Synonym: Increased level of galactonate in erythrocytes
Tree Number: T3.6.11.5
database_cross_reference: HPO:HP:0410063

Increased level of hippuric acid in blood
type: Class
subclass of: Abnormality of carboxylic acid metabolism
Definition: An increase in the level of hippuric acid in the blood.
MCID: MC01399118
PMOID: PMO:00003913
Subclass_of: Abnormality of carboxylic acid metabolism
Synonym: Increased level of N-benzoylglycine in blood
Tree Number: T3.6.11.6
database_cross_reference: HPO:HP:0410065

Increased level of hippuric acid in urine
type: Class
subclass of: Abnormality of carboxylic acid metabolism
Definition: An increase in the level of hippuric acid in the urine.
MCID: MC01399119
PMOID: PMO:00003914
Subclass_of: Abnormality of carboxylic acid metabolism
Synonym: Increased level of N-benzoylglycine in urine
Tree Number: T3.6.11.7
database_cross_reference: HPO:HP:0410066

Abnormality of circulating protein level
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormal level of a circulating protein in the blood.
PMOID: PMO:00003915
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.12

Abnormal albumin level
type: Class
subclass of: Abnormality of circulating protein level
Definition: Deviation from normal concentration of albumin in the blood.
MCID: MC01395737
PMOID: PMO:00003916
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.1
database_cross_reference: HPO:HP:0012116

Abnormal apolipoprotein level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A deviation from the normal concentration in blood of an apolipoprotein, i.e., of a protein that binds lipids to form lipoprotein and is thereby responsible for the transport of lipids in the blood and lymph circulation.
MCID: MC01395754
PMOID: PMO:00003919
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.2
database_cross_reference: HPO:HP:0025201

Abnormal B-type natriuretic peptide level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A deviation from the normal circulating concentration of B-type natriuretic peptide (BNP).
MCID: MC01395762
PMOID: PMO:00003924
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.3
database_cross_reference: HPO:HP:0031138

Abnormal circulating beta globulin level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A deviation from the normal concentration of beta globulin. The beta globulins are a group of globular (globe-shaped) proteins in blood.
MCID: MC01395814
PMOID: PMO:00003926
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.4
database_cross_reference: HPO:HP:0025465

Abnormal circulating beta-C-terminal telopeptide level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A deviation from the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation, a marker of the rate of bone turnover.
MCID: MC01395815
PMOID: PMO:00003934
Subclass_of: Abnormality of circulating protein level
Synonym: Abnormal circulating beta-CTx level
Synonym: Abnormal circulating beta-CrossLaps level
Tree Number: T3.6.12.5
database_cross_reference: HPO:HP:0031424

Abnormal circulating thyroglobulin level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A deviation from the normal concentration of thyroglobulin, a protein produced in the thyroid gland that acts as a precursor to thyrroid hormones.
MCID: MC01395831
PMOID: PMO:00003937
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.6
database_cross_reference: HPO:HP:0025483

Abnormal hepcidin level
type: Class
subclass of: Abnormality of circulating protein level
Definition: Any deviation from the normal concentration of hepcidin in the blood circulation.
MCID: MC01395927
PMOID: PMO:00003939
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.7
database_cross_reference: HPO:HP:0031875

Abnormal insulin like growth factor binding protein acid labile subunit level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A deviation from the normal blood concentration of the insulin like growth factor binding protein acid labile subunit (IGFALS; Entrez Gene ID 3483). The acid-labile subunit (IGFALS) acts in the insulin-like growth (IGF) system by binding circulating IGF1 in a ternary complex with binding protein (IGFBP)-3 to prevent IGF1 from crossing the endothelial barrier.
MCID: MC01395942
PMOID: PMO:00003942
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.8
database_cross_reference: HPO:HP:0031034

Abnormal levels of alpha-fetoprotein
type: Class
subclass of: Abnormality of circulating protein level
MCID: MC01395968
PMOID: PMO:00003944
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.9
database_cross_reference: HPO:HP:0045056

Abnormal retinol-binding protein level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A deviation from normal blood concentration of retinol-binding protein (RBP). The most commonly used indicator of vitamin A status is the serum retinol concentration (retinol is one of the several compounds known as vitamin A). The serum RBP concentration is used as a surrogate measure for serum retinol.
MCID: MC01396113
PMOID: PMO:00003949
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.10
database_cross_reference: HPO:HP:0031031

Abnormality of circulating enzyme level
type: Class
subclass of: Abnormality of circulating protein level
MCID: MC01396266
PMOID: PMO:00003951
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.11
database_cross_reference: HPO:HP:0011021

Abnormality of the kinin-kallikrein system
type: Class
subclass of: Abnormality of circulating protein level
MCID: MC01002649
PMOID: PMO:00003958
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.12
database_cross_reference: HPO:HP:0005559

Decreased prealbumin level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A reduced concentration of prealbumin in the blood. Prealbumin, also known as transthyretin, has a half-life in plasma of about 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status.
MCID: MC01397637
PMOID: PMO:00003959
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.13
database_cross_reference: HPO:HP:0031085

Elevated C-reactive protein level
type: Class
subclass of: Abnormality of circulating protein level
Definition: An abnormal elevation of the C-reactive protein level in serum.
MCID: MC01398041
PMOID: PMO:00003960
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.14
database_cross_reference: HPO:HP:0011227

Elevated carcinoembryonic antigen level
type: Class
subclass of: Abnormality of circulating protein level
Definition: An increased blood concentration of the carcinoembryonic antigen (CEA). CEA is a member of the immunoglobulin supergene family. The human CEA gene family is clustered on chromosome 19q and comprises 29 genes. CEA is highly expressed in embryonic tissue and in some cancers, and is a widely used tumor marker.
MCID: MC01398043
PMOID: PMO:00003961
Subclass_of: Abnormality of circulating protein level
Synonym: Increased plasma CEA
Tree Number: T3.6.12.15
database_cross_reference: HPO:HP:0031029

Elevated carcinoma antigen 125 level
type: Class
subclass of: Abnormality of circulating protein level
Definition: An increased blood concentration of carcinoma antigen 125 (CA-125). CA-125, also known as mucin 16, can exhibit increased blood levels in certain types of cancer.
MCID: MC01398044
PMOID: PMO:00003962
Subclass_of: Abnormality of circulating protein level
Synonym: Increased plasma CA125
Tree Number: T3.6.12.16
database_cross_reference: HPO:HP:0031030

Elevated prostate-specific antigen level
type: Class
subclass of: Abnormality of circulating protein level
Definition: An increased concentration of prostate specific antigen (PSA) in the circulation.
MCID: MC01398087
PMOID: PMO:00003963
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.17
database_cross_reference: HPO:HP:0025020

Hyperpepsinogenemia I
type: Class
subclass of: Abnormality of circulating protein level
MCID: MC01002950
PMOID: PMO:00003964
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.18
database_cross_reference: HPO:HP:0003238

Hyperproteinemia
type: Class
subclass of: Abnormality of circulating protein level
Definition: An increased concentration of proteins in the blood.
MCID: MC00092392
PMOID: PMO:00003965
Subclass_of: Abnormality of circulating protein level
Synonym: HYPERPROTEINEMIA
Synonym: Hyperproteinaemia
Synonym: Hyperproteinemia (disorder)
Synonym: Hyperproteinemia, NOS
Synonym: hyperproteinemia
Synonym: hyperproteinemia (diagnosis)
Tree Number: T3.6.12.19
database_cross_reference: CCPSS:0019965
database_cross_reference: CHV:0000026240
database_cross_reference: CSP:0449-5410
database_cross_reference: HPO:HP:0002152
database_cross_reference: MDR:10020740
database_cross_reference: MDR:10054418
database_cross_reference: MEDCIN:311892
database_cross_reference: SNM:F-12213
database_cross_reference: SNMI:D6-11010
database_cross_reference: SNOMEDCT_US:154750002
database_cross_reference: SNOMEDCT_US:267503004
database_cross_reference: SNOMEDCT_US:37064009
database_cross_reference: SNOMEDCT_VET:81647003

Hypoproteinemia
type: Class
subclass of: Abnormality of circulating protein level
Definition: A decreased concentration of protein in the blood.
MCID: MC00006625
PMOID: PMO:00003966
Subclass_of: Abnormality of circulating protein level
Synonym: HYPOPROTEINAEMIA
Synonym: HYPOPROTEINEMIA
Synonym: Hypoproteinaemia
Synonym: Hypoproteinaemia, NOS
Synonym: Hypoproteinemia (disorder)
Synonym: Hypoproteinemia [Disease/Finding]
Synonym: Hypoproteinemia, NOS
Synonym: Hypoproteinemias
Synonym: hypoproteinaemia
Synonym: hypoproteinemia
Tree Number: T3.6.12.20
database_cross_reference: AOD:0000005745
database_cross_reference: CCPSS:1006879
database_cross_reference: CHV:0000006489
database_cross_reference: CSP:0449-7033
database_cross_reference: CST:HYPOPROTEINEM
database_cross_reference: CST:METHYPOPROT
database_cross_reference: HPO:HP:0003075
database_cross_reference: MDR:10021083
database_cross_reference: MDR:10021084
database_cross_reference: MEDCIN:313654
database_cross_reference: MSH:D007019
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000348
database_cross_reference: NCI:C88511
database_cross_reference: NDFRT:N0000001646
database_cross_reference: OMIM:MTHU001376
database_cross_reference: RCD:C33y0
database_cross_reference: RCDAE:C33y0
database_cross_reference: SNM:F-12214
database_cross_reference: SNMI:D6-10244
database_cross_reference: SNOMEDCT_US:154750002
database_cross_reference: SNOMEDCT_US:267503004
database_cross_reference: SNOMEDCT_US:8900005
database_cross_reference: SNOMEDCT_VET:60439007

Increased circulating thyroxine-binding globulin level
type: Class
subclass of: Abnormality of circulating protein level
Definition: An elevated concentration of thyroxine-binding globulin (TBG) in the blood.
MCID: MC01399046
PMOID: PMO:00003968
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.21
database_cross_reference: HPO:HP:0031222

Reduced growth-hormone binding protein level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A decreased blood concentration of growth hormone binding protein.
MCID: MC01400827
PMOID: PMO:00003969
Subclass_of: Abnormality of circulating protein level
Synonym: Decreased plasma GH-binding protein
Tree Number: T3.6.12.22
database_cross_reference: HPO:HP:0031036

Reduced insulin-like factor 3 level
type: Class
subclass of: Abnormality of circulating protein level
Definition: Blood concentration of insulin-like factor 3 (ILF3) is below normal limits.
MCID: MC01400832
PMOID: PMO:00003970
Subclass_of: Abnormality of circulating protein level
Synonym: Reduced plasma INSL3 level
Tree Number: T3.6.12.23
database_cross_reference: HPO:HP:0031037

Reduced serum alpha-1-antitrypsin
type: Class
subclass of: Abnormality of circulating protein level
Definition: A reduced concentration of circulating alpha-1 antitrypsin, which is a 52-kDa glycoprotein mainly synthesised and secreted by hepatocytes into the bloodstream. Alpha-1 antitrypsin is a serine-proteinase inhibitor that it is crucial in maintaining protease-antiprotease homeostasis in the lungs.
MCID: MC01400879
PMOID: PMO:00003971
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.24
database_cross_reference: HPO:HP:0032025

Reduced sex -hormone binding protein level
type: Class
subclass of: Abnormality of circulating protein level
Definition: A decreased concentration of sex-hormone binding protein in the circulation.
MCID: MC01400880
PMOID: PMO:00003972
Subclass_of: Abnormality of circulating protein level
Synonym: Reduced androgen-binding protein level
Tree Number: T3.6.12.25
database_cross_reference: HPO:HP:0031419

Reduced thyroxin-binding globulin
type: Class
subclass of: Abnormality of circulating protein level
Definition: An abnormally decreased amount of thyroxin-binding globulin (TBG) in blood. TBG is responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream.
MCID: MC01400886
PMOID: PMO:00003973
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.26
database_cross_reference: HPO:HP:0012509

Abnormality of fluid regulation
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality of the regulation of body fluids.
MCID: MC00721794
PMOID: PMO:00003974
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Disorder of fluid balance
Synonym: Disorder;fluids
Synonym: Fluid imbalance
Synonym: Fluid imbalance (disorder)
Synonym: Fluid volume alteration
Synonym: Fluid volume alteration (finding)
Synonym: Fluid volume disorder
Synonym: Fluid volume disorder (disorder)
Synonym: Fluid volume disorder, NOS
Synonym: VOLUME DISORDER
Tree Number: T3.6.13
database_cross_reference: CHV:0000026243
database_cross_reference: CHV:0000049781
database_cross_reference: CST:PATHVOLDIS
database_cross_reference: HPO:HP:0011032
database_cross_reference: ICPC2P:T99009
database_cross_reference: LNC:MTHU013361
database_cross_reference: MDR:10051283
database_cross_reference: MEDCIN:314405
database_cross_reference: RCD:C36z2
database_cross_reference: RCD:X208k
database_cross_reference: SNMI:D6-20100
database_cross_reference: SNOMEDCT_US:129848002
database_cross_reference: SNOMEDCT_US:1860003
database_cross_reference: SNOMEDCT_US:190902006

Dehydration
type: Class
subclass of: Abnormality of fluid regulation
MCID: MC00003587
PMOID: PMO:00003975
Subclass_of: Abnormality of fluid regulation
Synonym: DEHYDRATION
Synonym: Deficient fluid volume
Synonym: Dehydrated
Synonym: Dehydration (disorder)
Synonym: Dehydration [Disease/Finding]
Synonym: Dehydration syndrome
Synonym: Exsiccosis
Synonym: Pure water depletion syndrome
Synonym: body water dehydration
Synonym: deficient fluid volume
Tree Number: T3.6.13.1
database_cross_reference: AOD:0000005833
database_cross_reference: CCPSS:1015105
database_cross_reference: CHV:0000003663
database_cross_reference: COSTAR:220
database_cross_reference: CSP:0465-2856
database_cross_reference: CST:DEHYDRAT
database_cross_reference: DXP:U000936
database_cross_reference: HPO:HP:0001944
database_cross_reference: ICD10CM:E86.0
database_cross_reference: ICD9CM:276.51
database_cross_reference: ICPC2EENG:T11
database_cross_reference: ICPC2P:T11001
database_cross_reference: LNC:MTHU020843
database_cross_reference: MDR:10012174
database_cross_reference: MDR:10054198
database_cross_reference: MEDLINEPLUS:6051
database_cross_reference: MSH:D003681
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26740
database_cross_reference: NCI_CTCAE:E12258
database_cross_reference: NCI_FDA:1807
database_cross_reference: NCI_NCI-GLOSS:CDR0000044659
database_cross_reference: NCI_NICHD:C26740
database_cross_reference: NDFRT:N0000000911
database_cross_reference: OMIM:MTHU000177
database_cross_reference: PSY:13285
database_cross_reference: RCD:XM00s
database_cross_reference: SNM:D-1172
database_cross_reference: SNM:F-01790
database_cross_reference: SNMI:D6-20650
database_cross_reference: SNOMEDCT_US:154759001
database_cross_reference: SNOMEDCT_US:34095006
database_cross_reference: SNOMEDCT_US:37472003

Edema
type: Class
subclass of: Abnormality of fluid regulation
Definition: An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
MCID: MC00004304
PMOID: PMO:00003978
Subclass_of: Abnormality of fluid regulation
Synonym: 363-364 EDEMAS
Synonym: Dropsy
Synonym: Dropsy, NOS
Synonym: EDEMA
Synonym: EDEMA (NOS)
Synonym: EDEMA NOS
Synonym: EDEMAS
Synonym: EDEMATOUS
Synonym: Edema (NOS)
Synonym: Edema (finding)
Tree Number: T3.6.13.2
database_cross_reference: AOD:0000005462
database_cross_reference: AOD:0000005836
database_cross_reference: BI:BI00114
database_cross_reference: CCPSS:1000739
database_cross_reference: CCPSS:1014846
database_cross_reference: CHV:0000004269
database_cross_reference: CHV:0000029664
database_cross_reference: COSTAR:273
database_cross_reference: CSP:0465-4760
database_cross_reference: CST:EDEMA
database_cross_reference: HPO:HP:0000969
database_cross_reference: ICD10:R60.9
database_cross_reference: ICD10AM:R60.9
database_cross_reference: ICD10AMAE:R60.9
database_cross_reference: ICD10CM:R60.9
database_cross_reference: ICD9CM:782.3
database_cross_reference: ICPC2P:K07003
database_cross_reference: LCH:U001504
database_cross_reference: LCH_NW:sh85040948
database_cross_reference: LNC:LA17263-7
database_cross_reference: LNC:LA19035-7
database_cross_reference: LNC:MTHU019803
database_cross_reference: MDR:10014210
database_cross_reference: MDR:10014211
database_cross_reference: MDR:10014234
database_cross_reference: MDR:10030095
database_cross_reference: MDR:10030114
database_cross_reference: MEDCIN:278545
database_cross_reference: MEDCIN:7268
database_cross_reference: MEDLINEPLUS:1229
database_cross_reference: MSH:D004487
database_cross_reference: MTH:715
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:782.3
database_cross_reference: NCI:C3002
database_cross_reference: NCI_CDISC:C3002
database_cross_reference: NCI_FDA:1820
database_cross_reference: NCI_NCI-GLOSS:CDR0000045676
database_cross_reference: NCI_NICHD:C3002
database_cross_reference: NDFRT:N0000001057
database_cross_reference: OMIM:MTHU000002
database_cross_reference: OMIM:MTHU007987
database_cross_reference: RCD:183Z.
database_cross_reference: RCD:R023.
database_cross_reference: RCD:R0232
database_cross_reference: RCD:R023z
database_cross_reference: RCD:X78zV
database_cross_reference: RCD:XE0qw
database_cross_reference: RCDAE:183Z.
database_cross_reference: RCDAE:R023.
database_cross_reference: RCDAE:R023z
database_cross_reference: RCDAE:X78zV
database_cross_reference: RCDAE:XE0qw
database_cross_reference: RCDSY:R023.
database_cross_reference: RCDSY:R0232
database_cross_reference: RCDSY:R023z
database_cross_reference: SNM:M-36500
database_cross_reference: SNM:U000308
database_cross_reference: SNMI:M-36010
database_cross_reference: SNMI:M-36300
database_cross_reference: SNOMEDCT_US:139241006
database_cross_reference: SNOMEDCT_US:139250008
database_cross_reference: SNOMEDCT_US:155375008

Abnormality of glycoprotein metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality of a glycoprotein metabolic process.
MCID: MC01396299
PMOID: PMO:00004001
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.14
database_cross_reference: HPO:HP:0004367

Abnormality of proteoglycan metabolism
type: Class
subclass of: Abnormality of glycoprotein metabolism
Definition: An abnormality of proteoglycan metabolism.
MCID: MC01396349
PMOID: PMO:00004002
Subclass_of: Abnormality of glycoprotein metabolism
Tree Number: T3.6.14.1
database_cross_reference: HPO:HP:0004355

Reduced activity of N-acetylglucosaminyltransferase II
type: Class
subclass of: Abnormality of glycoprotein metabolism
Definition: An abnormality of glycoprotein metabolism related to a decreased rate of alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity.
MCID: MC01400785
PMOID: PMO:00004004
Subclass_of: Abnormality of glycoprotein metabolism
Synonym: Deficient N-acetylglucosaminyltransferase II
Tree Number: T3.6.14.2
database_cross_reference: HPO:HP:0003655

Abnormality of ion homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: Abnormality of the homeostasis (concentration) of a monoatomic ion.
MCID: MC01002955
PMOID: PMO:00004005
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.15
database_cross_reference: HPO:HP:0003111

Abnormality of cation homeostasis
type: Class
subclass of: Abnormality of ion homeostasis
Definition: An abnormality of cation homeostasis.
MCID: MC01396254
PMOID: PMO:00004006
Subclass_of: Abnormality of ion homeostasis
Tree Number: T3.6.15.1
database_cross_reference: HPO:HP:0010929

Abnormality of chloride homeostasis
type: Class
subclass of: Abnormality of ion homeostasis
Definition: An abnormality of chloride homeostasis or concentration in the body.
MCID: MC01396256
PMOID: PMO:00004050
Subclass_of: Abnormality of ion homeostasis
Tree Number: T3.6.15.2
database_cross_reference: HPO:HP:0011422

Abnormality of phosphate homeostasis
type: Class
subclass of: Abnormality of ion homeostasis
Definition: An abnormality of phosphate homeostasis or concentration in the body.
MCID: MC01396343
PMOID: PMO:00004054
Subclass_of: Abnormality of ion homeostasis
Tree Number: T3.6.15.3
database_cross_reference: HPO:HP:0100529

Abnormality of Krebs cycle metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality of the tricarboxylic acid cycle.
MCID: MC01396315
PMOID: PMO:00004062
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Abnormality of citric acid cycle
Synonym: Abnormality of the tricarboxylic cycle
Tree Number: T3.6.16
database_cross_reference: HPO:HP:0000816

Decreased fumarate hydratase activity
type: Class
subclass of: Abnormality of Krebs cycle metabolism
Definition: An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of fumarate hydratase activity.
MCID: MC01397560
PMOID: PMO:00004063
Subclass_of: Abnormality of Krebs cycle metabolism
Tree Number: T3.6.16.1
database_cross_reference: HPO:HP:0003536

Decreased methylmalonyl-CoA mutase activity
type: Class
subclass of: Abnormality of Krebs cycle metabolism
Definition: An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of methylmalonyl-CoA mutase activity.
MCID: MC01397608
PMOID: PMO:00004064
Subclass_of: Abnormality of Krebs cycle metabolism
Synonym: Decreased methylmalonyl CoA mutase activity
Tree Number: T3.6.16.2
database_cross_reference: HPO:HP:0003210

Decreased pyruvate carboxylase activity
type: Class
subclass of: Abnormality of Krebs cycle metabolism
Definition: A decreased rate of pyruvate carboxylase activity.
MCID: MC01397649
PMOID: PMO:00004065
Subclass_of: Abnormality of Krebs cycle metabolism
Tree Number: T3.6.16.3
database_cross_reference: HPO:HP:0003209

Abnormality of lipid metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality in the of lipid metabolism.
PMOID: PMO:00004066
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.17

Abnormal level of phospholipids
type: Class
subclass of: Abnormality of lipid metabolism
MCID: MC01395966
PMOID: PMO:00004067
Subclass_of: Abnormality of lipid metabolism
Tree Number: T3.6.17.1
database_cross_reference: HPO:HP:0040176

Abnormality of cholesterol metabolism
type: Class
subclass of: Abnormality of lipid metabolism
MCID: MC01396257
PMOID: PMO:00004071
Subclass_of: Abnormality of lipid metabolism
Tree Number: T3.6.17.2
database_cross_reference: HPO:HP:0003107

Abnormality of fatty-acid metabolism
type: Class
subclass of: Abnormality of lipid metabolism
Definition: An abnormality of fatty acid metabolism.
MCID: MC01396283
PMOID: PMO:00004096
Subclass_of: Abnormality of lipid metabolism
Synonym: Abnormality of fatty acid metabolism
Tree Number: T3.6.17.3
database_cross_reference: HPO:HP:0004359

Abnormality of liposaccharide metabolism
type: Class
subclass of: Abnormality of lipid metabolism
Definition: An abnormality of liposaccharide metabolism.
MCID: MC01396317
PMOID: PMO:00004123
Subclass_of: Abnormality of lipid metabolism
Tree Number: T3.6.17.4
database_cross_reference: HPO:HP:0010968

Hyperapobetalipoproteinemia
type: Class
subclass of: Abnormality of lipid metabolism
Definition: Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein.
MCID: MC00006546
PMOID: PMO:00004131
Subclass_of: Abnormality of lipid metabolism
Synonym: COMBINED HYPERLIPIDEMIA, FAMILIAL
Synonym: Combined Hyperlipidemia, Familial
Synonym: Combined Hyperlipidemias, Familial
Synonym: FAMILIAL COMBINED HYPERLIPIDEMIA
Synonym: FCHL
Synonym: FCHL (familial combined hyperlipidemia)
Synonym: FCHL - Familial combined hyperlipidaemia
Synonym: FCHL - Familial combined hyperlipidemia
Synonym: FCHL -Famil comb hyperlipidaem
Synonym: Fam hyperlipoproteinaemia IIb
Tree Number: T3.6.17.5
database_cross_reference: CHV:0000006420
database_cross_reference: DO:DOID:13809
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0008158
database_cross_reference: ICD10CM:E78.4
database_cross_reference: MDR:10045263
database_cross_reference: MDR:10054675
database_cross_reference: MEDCIN:33852
database_cross_reference: MEDLINEPLUS:26
database_cross_reference: MEDLINEPLUS:4277
database_cross_reference: MSH:D006950
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35637
database_cross_reference: NDFRT:N0000001593
database_cross_reference: OMIM:144250
database_cross_reference: OMIM:609708
database_cross_reference: RCD:X40Vm
database_cross_reference: RCDAE:X40Vm
database_cross_reference: SNMI:D6-60450
database_cross_reference: SNOMEDCT_US:154742006
database_cross_reference: SNOMEDCT_US:190780005
database_cross_reference: SNOMEDCT_US:238040008
database_cross_reference: SNOMEDCT_US:299465007
database_cross_reference: SNOMEDCT_US:48190005

Hyperlipidemia
type: Class
subclass of: Abnormality of lipid metabolism
Definition: An elevated lipid concentration in the blood.
MCID: MC00006545
PMOID: PMO:00004132
Subclass_of: Abnormality of lipid metabolism
Synonym: Disorder characterized by hyperlipidemia
Synonym: HLD - Hyperlipidaemia
Synonym: HLD - Hyperlipidemia
Synonym: HYPERLIPAEMIA
Synonym: HYPERLIPEMIA
Synonym: HYPERLIPIDEMIA
Synonym: Hyperlipaemia
Synonym: Hyperlipemia
Synonym: Hyperlipemias
Synonym: Hyperlipidaemia
Tree Number: T3.6.17.6
database_cross_reference: AOD:0000005732
database_cross_reference: BI:BI00109
database_cross_reference: CCPSS:1006712
database_cross_reference: CHV:0000006419
database_cross_reference: COSTAR:395
database_cross_reference: CSP:1744-2444
database_cross_reference: CST:HYPERLIPEM
database_cross_reference: DO:DOID:1168
database_cross_reference: DXP:U002027
database_cross_reference: HPO:HP:0003077
database_cross_reference: ICD10:E78.5
database_cross_reference: ICD10AM:E78.5
database_cross_reference: ICD10AMAE:E78.5
database_cross_reference: ICD10CM:E78.5
database_cross_reference: ICPC2P:T93008
database_cross_reference: LCH:U002308
database_cross_reference: LCH_NW:sh85063704
database_cross_reference: MDR:10020661
database_cross_reference: MDR:10020662
database_cross_reference: MDR:10020663
database_cross_reference: MDR:10020667
database_cross_reference: MDR:10062060
database_cross_reference: MEDLINEPLUS:26
database_cross_reference: MEDLINEPLUS:4277
database_cross_reference: MSH:D006949
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:272.4
database_cross_reference: NCI:C34707
database_cross_reference: NDFRT:N0000001592
database_cross_reference: OMIM:MTHU002043
database_cross_reference: RCD:C324.
database_cross_reference: RCD:X40Wy
database_cross_reference: RCDAE:C324.
database_cross_reference: RCDAE:X40Wy
database_cross_reference: SNMI:D6-60010
database_cross_reference: SNOMEDCT_US:154739000
database_cross_reference: SNOMEDCT_US:154743001
database_cross_reference: SNOMEDCT_US:190782002
database_cross_reference: SNOMEDCT_US:267499005
database_cross_reference: SNOMEDCT_US:55822004
database_cross_reference: SNOMEDCT_VET:55822004

Hypolipidemia
type: Class
subclass of: Abnormality of lipid metabolism
MCID: MC00120684
PMOID: PMO:00004136
Subclass_of: Abnormality of lipid metabolism
Synonym: HYPOLIPEMIA
Synonym: Hypolipaemia
Synonym: Hypolipemia
Synonym: Hypolipidaemia
Synonym: Hypolipidemia (disorder)
Synonym: hypolipemia
Synonym: hypolipidemia
Tree Number: T3.6.17.7
database_cross_reference: CHV:0000030801
database_cross_reference: CSP:1744-2978
database_cross_reference: CST:HYPOLIPEM
database_cross_reference: HPO:HP:0045014
database_cross_reference: MDR:10021023
database_cross_reference: MDR:10021024
database_cross_reference: MDR:10021025
database_cross_reference: MDR:10060386
database_cross_reference: OMIM:MTHU056858
database_cross_reference: RCD:X40XP
database_cross_reference: RCDAE:X40XP
database_cross_reference: SNOMEDCT_US:238090007

Abnormality of nitrogen compound homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: The presence of an abnormal concentration of nitrogen compounds.
MCID: MC01396331
PMOID: PMO:00004138
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.18
database_cross_reference: HPO:HP:0004364

Abnormal blood urea nitrogen
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: Any deviation from the normal concentration of urea nitrogen in the blood.
MCID: MC01395770
PMOID: PMO:00004139
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.1
database_cross_reference: HPO:HP:0031970

Abnormal circulating creatinine level
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: An abnormal concentration of creatinine in the blood.
MCID: MC01395816
PMOID: PMO:00004142
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: Abnormal blood creatinine level
Synonym: Creatinine levels abnormal
Tree Number: T3.6.18.2
database_cross_reference: HPO:HP:0012100

Abnormal circulating nicotinurate level
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: Any deviation from the normal concentration of nicotinurate in the blood.
MCID: MC01395827
PMOID: PMO:00004144
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: Abnormal circulating N-nicotinoylglycine level
Tree Number: T3.6.18.3
database_cross_reference: HPO:HP:0410205

Abnormal level of biopterin
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: The presence of an abnormal concentration of biopterin.
MCID: MC01395964
PMOID: PMO:00004146
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.4
database_cross_reference: HPO:HP:0040210

Abnormal level of neopterin
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: The presence of an abnormal concentration of neopterin.
MCID: MC01395965
PMOID: PMO:00004150
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.5
database_cross_reference: HPO:HP:0040206

Azotemia
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: An increased concentration of nitrogen compounds in the blood.
MCID: MC00081669
PMOID: PMO:00004154
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: AZOTEMIA
Synonym: Azotaemia
Synonym: Azotemia (disorder)
Synonym: Azotemia (finding)
Synonym: Azotemia [Disease/Finding]
Synonym: azotaemia
Synonym: azotemia
Tree Number: T3.6.18.6
database_cross_reference: CCPSS:1001585
database_cross_reference: CHV:0000024863
database_cross_reference: COSTAR:091
database_cross_reference: CSP:1682-3281
database_cross_reference: CST:NPN INC
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0002157
database_cross_reference: LCH:U006263
database_cross_reference: LCH_NW:sh85010664
database_cross_reference: MDR:10003885
database_cross_reference: MDR:10003886
database_cross_reference: MSH:D053099
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000181077
database_cross_reference: OMIM:MTHU013356
database_cross_reference: SNM:F-10463
database_cross_reference: SNMI:D7-11028
database_cross_reference: SNOMEDCT_US:445009001
database_cross_reference: SNOMEDCT_VET:282151000009107

Episodic ammonia intoxication
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
MCID: MC01398194
PMOID: PMO:00004160
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.7
database_cross_reference: HPO:HP:0001951

Hyperuricosuria
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: An abnormally high level of uric acid in the urine.
MCID: MC01398734
PMOID: PMO:00004161
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: High urine uric acid level
Tree Number: T3.6.18.8
database_cross_reference: HPO:HP:0003149

Hypoammonemia
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: A decreased concentration of ammonia in the blood.
MCID: MC01000537
PMOID: PMO:00004162
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.9
database_cross_reference: HPO:HP:0100493

Increased level of allantoin in serum
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: An increase in the level of allantoin in the serum.
MCID: MC01399107
PMOID: PMO:00004163
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.10
database_cross_reference: HPO:HP:0410052

Urocanic aciduria
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
Definition: An increased concentration of urocanic acid in the urine.
MCID: MC00092804
PMOID: PMO:00004164
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: High urine urocanic acid levels
Synonym: UROCANASE DEFICIENCY
Synonym: UROCD
Synonym: Urocanase deficiency
Synonym: Urocanate hydratase deficiency
Synonym: Urocanate hydratase deficiency (disorder)
Tree Number: T3.6.18.11
database_cross_reference: HPO:HP:0012237
database_cross_reference: MSH:C536479
database_cross_reference: OMIM:276880
database_cross_reference: OMIM:MTHU037990
database_cross_reference: RCD:X40S7
database_cross_reference: SNMI:D6-A3120
database_cross_reference: SNOMEDCT_US:60952007

Abnormality of nucleobase metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality of a nucleobase metabolic process.
MCID: MC01396332
PMOID: PMO:00004165
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.19
database_cross_reference: HPO:HP:0010932

Abnormality of purine metabolism
type: Class
subclass of: Abnormality of nucleobase metabolism
MCID: MC01396351
PMOID: PMO:00004166
Subclass_of: Abnormality of nucleobase metabolism
Tree Number: T3.6.19.1
database_cross_reference: HPO:HP:0004352

Abnormality of pyrimidine metabolism
type: Class
subclass of: Abnormality of nucleobase metabolism
Definition: An abnormality of a pyrimidine base metabolic process.
MCID: MC01396352
PMOID: PMO:00004177
Subclass_of: Abnormality of nucleobase metabolism
Tree Number: T3.6.19.2
database_cross_reference: HPO:HP:0004353

Increased phosphoribosylpyrophosphate synthetase
type: Class
subclass of: Abnormality of nucleobase metabolism
MCID: MC01399159
PMOID: PMO:00004182
Subclass_of: Abnormality of nucleobase metabolism
Synonym: Increased PRPP synthetase
Tree Number: T3.6.19.3
database_cross_reference: HPO:HP:0003240

Abnormality of superoxide metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
MCID: MC01396368
PMOID: PMO:00004183
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.20
database_cross_reference: HPO:HP:0004358

Decreased activity of NADPH oxidase
type: Class
subclass of: Abnormality of superoxide metabolism
MCID: MC01397495
PMOID: PMO:00004184
Subclass_of: Abnormality of superoxide metabolism
Tree Number: T3.6.20.1
database_cross_reference: HPO:HP:0003206

Abnormality of temperature regulation
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality of temperature homeostasis.
PMOID: PMO:00004185
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.21

Fever
type: Class
subclass of: Abnormality of temperature regulation
Definition: Elevated body temperature due to failed thermoregulation.
MCID: MC00005087
PMOID: PMO:00004186
Subclass_of: Abnormality of temperature regulation
Synonym: BODY TEMPERATURE INCREASED
Synonym: Body temperature above normal
Synonym: Body temperature above normal (finding)
Synonym: Body temperature above reference range
Synonym: Body temperature above reference range (finding)
Synonym: Body temperature increased
Synonym: Body temperature, increased
Synonym: Elevated Core Body Temperature
Synonym: FEVER
Synonym: Febrile
Tree Number: T3.6.21.1
database_cross_reference: AOD:0000004396
database_cross_reference: AOD:0000004726
database_cross_reference: AOD:0000022968
database_cross_reference: BI:BI00751
database_cross_reference: CCPSS:0015064
database_cross_reference: CCPSS:1017166
database_cross_reference: CHV:0000005010
database_cross_reference: CHV:0000022653
database_cross_reference: CHV:0000022654
database_cross_reference: COSTAR:300
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2871-4310
database_cross_reference: CST:FEVER
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001483
database_cross_reference: GO:GO:0001660
database_cross_reference: HPO:HP:0001945
database_cross_reference: ICD10:R50.9
database_cross_reference: ICD10AM:R50.9
database_cross_reference: ICD10CM:R50.9
database_cross_reference: ICD9CM:780.60
database_cross_reference: ICPC2EENG:A03
database_cross_reference: ICPC2P:A03002
database_cross_reference: ICPC2P:A03006
database_cross_reference: LCH:U001776
database_cross_reference: LCH_NW:sh85047994
database_cross_reference: LNC:LA9540-1
database_cross_reference: LNC:MTHU013245
database_cross_reference: LNC:MTHU013518
database_cross_reference: MDR:10005911
database_cross_reference: MDR:10016558
database_cross_reference: MDR:10020083
database_cross_reference: MDR:10020843
database_cross_reference: MDR:10037660
database_cross_reference: MDR:10037663
database_cross_reference: MDR:10037668
database_cross_reference: MDR:10043204
database_cross_reference: MDR:10073718
database_cross_reference: MEDCIN:278512
database_cross_reference: MEDCIN:314447
database_cross_reference: MEDCIN:6005
database_cross_reference: MEDLINEPLUS:511
database_cross_reference: MSH:D005334
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.60
database_cross_reference: NCI:C3038
database_cross_reference: NCI:C50589
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CTCAE:E11102
database_cross_reference: NCI_FDA:1858
database_cross_reference: NCI_FDA:1909
database_cross_reference: NCI_NCI-GLOSS:CDR0000450108
database_cross_reference: NCI_NCI-GLOSS:CDR0000468790
database_cross_reference: NCI_NICHD:C3038
database_cross_reference: NCI_NICHD:C50589
database_cross_reference: NDFRT:N0000001242
database_cross_reference: OMIM:MTHU005439
database_cross_reference: OMIM:MTHU015481
database_cross_reference: PSY:19660
database_cross_reference: PSY:23840
database_cross_reference: RCD:R0062
database_cross_reference: RCD:X76Df
database_cross_reference: RCD:X76Di

Heat intolerance
type: Class
subclass of: Abnormality of temperature regulation
Definition: The inability to maintain a comfortably body temperature in warm or hot weather.
MCID: MC00077950
PMOID: PMO:00004190
Subclass_of: Abnormality of temperature regulation
Synonym: Gets overheated
Synonym: HEAT INTOLERANCE
Synonym: HEAT SENSITIVITY
Synonym: Heat sensitivity
Synonym: Intolerance to heat and fevers
Synonym: Intolerant of heat
Synonym: Intolerant of heat (finding)
Synonym: Sensitive to heat
Synonym: heat intolerance
Synonym: heat sensitive
Tree Number: T3.6.21.2
database_cross_reference: CCPSS:0029041
database_cross_reference: CHV:0000022656
database_cross_reference: COSTAR:U000326
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001918
database_cross_reference: HPO:HP:0002046
database_cross_reference: MDR:10019339
database_cross_reference: MDR:10056596
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU007764
database_cross_reference: OMIM:MTHU016858
database_cross_reference: RCD:X76Ea
database_cross_reference: SNM:F-03170
database_cross_reference: SNMI:F-03170
database_cross_reference: SNOMEDCT_US:69215007
database_cross_reference: SNOMEDCT_VET:69215007

Hypothermia
type: Class
subclass of: Abnormality of temperature regulation
Definition: Reduced body temperature due to failed thermoregulation.
MCID: MC01398883
PMOID: PMO:00004191
Subclass_of: Abnormality of temperature regulation
Synonym: Abnormally low body temperature
Tree Number: T3.6.21.3
database_cross_reference: HPO:HP:0002045

Impaired thermal sensitivity
type: Class
subclass of: Abnormality of temperature regulation
MCID: MC01398955
PMOID: PMO:00004193
Subclass_of: Abnormality of temperature regulation
Tree Number: T3.6.21.4
database_cross_reference: HPO:HP:0006901

Malignant hyperthermia
type: Class
subclass of: Abnormality of temperature regulation
Definition: Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C in response to inhalational anesthetics such as halothane or to muscle relaxants such as succinylcholine.
MCID: MC00007858
PMOID: PMO:00004194
Subclass_of: Abnormality of temperature regulation
Synonym: Anesthesia Hyperthermia
Synonym: Anesthesia Hyperthermias
Synonym: Anesthesia Related Hyperthermia
Synonym: Anesthesia Related Hyperthermias
Synonym: FEVER MALIGNANT
Synonym: Fever malignant
Synonym: HYPERPYREXIA MALIGNANT
Synonym: HYPERPYREXIA, FULMINATING
Synonym: HYPERPYREXIA, MALIGNANT
Synonym: HYPERTHERMIA MALIGNANT
Tree Number: T3.6.21.5
database_cross_reference: CCPSS:0046783
database_cross_reference: CHV:0000007696
database_cross_reference: CHV:0000058199
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2871-4352
database_cross_reference: CST:FEVER MALIGNANT
database_cross_reference: DO:DOID:8545
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000888
database_cross_reference: HPO:HP:0002047
database_cross_reference: ICD10:T88.3
database_cross_reference: ICD10AM:T88.3
database_cross_reference: ICD10AMAE:T88.3
database_cross_reference: ICD10CM:T88.3
database_cross_reference: ICD9CM:995.86
database_cross_reference: ICPC2P:A03007
database_cross_reference: LCH:U002793
database_cross_reference: LCH_NW:sh85080155
database_cross_reference: MDR:10016561
database_cross_reference: MDR:10020742
database_cross_reference: MDR:10020844
database_cross_reference: MDR:10025599
database_cross_reference: MDR:10025606
database_cross_reference: MDR:10025607
database_cross_reference: MEDCIN:311081
database_cross_reference: MEDCIN:33656
database_cross_reference: MSH:D008305
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:995.86
database_cross_reference: NCI:C84869
database_cross_reference: NCI_NICHD:C84869
database_cross_reference: NDFRT:N0000001928
database_cross_reference: OMIM:145600
database_cross_reference: OMIM:180901
database_cross_reference: OMIM:MTHU023121
database_cross_reference: RCD:SN5y0
database_cross_reference: RCD:X709O
database_cross_reference: RCDAE:SN5y0
database_cross_reference: SNM:D-1065
database_cross_reference: SNMI:DD-64B00
database_cross_reference: SNOMEDCT_US:111738008
database_cross_reference: SNOMEDCT_US:157762007
database_cross_reference: SNOMEDCT_US:213026003
database_cross_reference: SNOMEDCT_US:248453001
database_cross_reference: SNOMEDCT_US:269435009
database_cross_reference: SNOMEDCT_US:405500008
database_cross_reference: SNOMEDCT_US:405501007

Temperature instability
type: Class
subclass of: Abnormality of temperature regulation
Definition: Disordered thermoregulation characterized by an impaired ability to maintain a balance between heat production and heat loss, with resulting instability of body temperature.
MCID: MC01401417
PMOID: PMO:00004195
Subclass_of: Abnormality of temperature regulation
Tree Number: T3.6.21.6
database_cross_reference: HPO:HP:0005968

Abnormality of the heme biosynthetic pathway
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An abnormality in the synthesis or catabolism of heme. Heme is composed of ferrous iron and protoporphyrin IX and is an essential molecule as the prosthetic group of hemeproteins such as hemoglobin, myoglobin, mitochondrial and microsomal cytochromes.
MCID: MC01396384
PMOID: PMO:00004196
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.22
database_cross_reference: HPO:HP:0010472

Elevated urinary delta-aminolevulinic acid
type: Class
subclass of: Abnormality of the heme biosynthetic pathway
Definition: An increased concentration of 5-aminolevulinic acid (CHEBI:17549) in the urine.
MCID: MC01398109
PMOID: PMO:00004197
Subclass_of: Abnormality of the heme biosynthetic pathway
Tree Number: T3.6.22.1
database_cross_reference: HPO:HP:0003163

Increased erythrocyte protoporphyrin concentration
type: Class
subclass of: Abnormality of the heme biosynthetic pathway
Definition: An increased concentration of protoporphyrins in erythrocytes.
MCID: MC01399061
PMOID: PMO:00004198
Subclass_of: Abnormality of the heme biosynthetic pathway
Tree Number: T3.6.22.2
database_cross_reference: HPO:HP:0012187

Increased urinary porphobilinogen
type: Class
subclass of: Abnormality of the heme biosynthetic pathway
Definition: Increased concentration of porphobilinogen in the urine.
MCID: MC01399247
PMOID: PMO:00004199
Subclass_of: Abnormality of the heme biosynthetic pathway
Tree Number: T3.6.22.3
database_cross_reference: HPO:HP:0012217

Porphyrinuria
type: Class
subclass of: Abnormality of the heme biosynthetic pathway
Definition: Abnormally increased excretion of porphyrins in the urine.
MCID: MC00058254
PMOID: PMO:00004200
Subclass_of: Abnormality of the heme biosynthetic pathway
Synonym: PORPHYRINURIA
Synonym: Porphyrins urinary excretion incr
Synonym: Porphyrins urinary excretion increased
Synonym: Porphyruria
Synonym: Porphyruria (disorder)
Synonym: porphyrinuria
Synonym: porphyrinuria (diagnosis)
Synonym: porphyruria
Tree Number: T3.6.22.4
database_cross_reference: CHV:0000017090
database_cross_reference: CST:PORPHYRINURIA
database_cross_reference: HPO:HP:0010473
database_cross_reference: MDR:10036191
database_cross_reference: MDR:10036192
database_cross_reference: MDR:10036193
database_cross_reference: MEDCIN:273595
database_cross_reference: MTHICD9:277.1
database_cross_reference: SNMI:D6-88420
database_cross_reference: SNOMEDCT_US:44574006

Abnormality of vitamin metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An anomaly in the metabolism of a vitamin.
MCID: MC01396434
PMOID: PMO:00004201
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.23
database_cross_reference: HPO:HP:0100508

Abnormality of vitamin A metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
MCID: MC01396427
PMOID: PMO:00004202
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.1
database_cross_reference: HPO:HP:0008372

Abnormality of vitamin B metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
MCID: MC01396428
PMOID: PMO:00004204
Subclass_of: Abnormality of vitamin metabolism
Synonym: Abnormality of B-vitamin metabolism
Tree Number: T3.6.23.2
database_cross_reference: HPO:HP:0004340

Abnormality of vitamin C metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
MCID: MC01396430
PMOID: PMO:00004225
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.3
database_cross_reference: HPO:HP:0100509

Abnormality of vitamin D metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
MCID: MC01396431
PMOID: PMO:00004227
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.4
database_cross_reference: HPO:HP:0100511

Abnormality of vitamin E metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
MCID: MC01396432
PMOID: PMO:00004233
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.5
database_cross_reference: HPO:HP:0100514

Abnormality of vitamin K metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
Definition: Vitamin K is a fat-soluble vitamin with a role in promoting the coagulation cascade.
MCID: MC01396433
PMOID: PMO:00004235
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.6
database_cross_reference: HPO:HP:0100831

Amyloidosis
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: The presence of amyloid deposition in one or more tissues. Amyloidosis may be defined as the extracellular deposition of amyloid in one or more sites of the body.
MCID: MC00000836
PMOID: PMO:00004238
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: AMYLOID
Synonym: AMYLOIDOSIS
Synonym: Amyloid disease
Synonym: Amyloidoses
Synonym: Amyloidosis (disorder)
Synonym: Amyloidosis NOS
Synonym: Amyloidosis NOS (disorder)
Synonym: Amyloidosis [Disease/Finding]
Synonym: Amyloidosis, NOS
Synonym: Amyloidosis, unspecified
Tree Number: T3.6.24
database_cross_reference: AOD:0000005846
database_cross_reference: CCPSS:0052113
database_cross_reference: CHV:0000001070
database_cross_reference: COSTAR:U000030
database_cross_reference: CSP:1849-1519
database_cross_reference: CST:AMYLOIDOSIS
database_cross_reference: CST:PATHAMYLOID
database_cross_reference: DO:DOID:9120
database_cross_reference: HPO:HP:0011034
database_cross_reference: ICD10:E85
database_cross_reference: ICD10:E85.9
database_cross_reference: ICD10AM:E85
database_cross_reference: ICD10AM:E85.9
database_cross_reference: ICD10CM:E85
database_cross_reference: ICD10CM:E85.9
database_cross_reference: ICD9CM:277.3
database_cross_reference: ICD9CM:277.30
database_cross_reference: ICPC2P:T99006
database_cross_reference: LCH:U000219
database_cross_reference: LCH_NW:sh85004724
database_cross_reference: MDR:10002021
database_cross_reference: MDR:10002022
database_cross_reference: MDR:10002023
database_cross_reference: MDR:10002024
database_cross_reference: MEDCIN:31790
database_cross_reference: MEDLINEPLUS:5273
database_cross_reference: MSH:D000686
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.30
database_cross_reference: NCI:C2868
database_cross_reference: NCI_CDISC:C2868
database_cross_reference: NCI_CDISC:SEND-NONNEO
database_cross_reference: NCI_CTEP-SDC:10002024
database_cross_reference: NCI_NCI-GLOSS:CDR0000045507
database_cross_reference: NDFRT:N0000000375
database_cross_reference: PDQ:CDR0000041926
database_cross_reference: RCD:C373.
database_cross_reference: RCD:C373z
database_cross_reference: SNM:D-3890
database_cross_reference: SNMI:D6-94500
database_cross_reference: SNOMEDCT_US:154769007
database_cross_reference: SNOMEDCT_US:17602002
database_cross_reference: SNOMEDCT_US:190931005

Amyloidosis of peripheral nerves
type: Class
subclass of: Amyloidosis
Definition: The presence of amyloid deposition in the nerves of the peripheral nervous system.
MCID: MC01000634
PMOID: PMO:00004239
Subclass_of: Amyloidosis
Tree Number: T3.6.24.1
database_cross_reference: HPO:HP:0100292

Cardiac amyloidosis
type: Class
subclass of: Amyloidosis
Definition: Extracellular deposition in cardiac tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding.
MCID: MC00092719
PMOID: PMO:00004240
Subclass_of: Amyloidosis
Synonym: AS transthyretin amyloidosis
Synonym: Amyloid cardiomyopathy
Synonym: Amyloid heart disease
Synonym: Amyloid heart muscle disease
Synonym: Amyloidosis of heart
Synonym: Amyloidosis of heart (disorder)
Synonym: Senile cardiac amyloidosis
Synonym: Senile cardiac amyloidosis (disorder)
Synonym: amyloid cardiomyopathy
Synonym: amyloid heart disease
Tree Number: T3.6.24.2
database_cross_reference: CHV:0000026303
database_cross_reference: HPO:HP:0030843
database_cross_reference: MDR:10002020
database_cross_reference: MDR:10007509
database_cross_reference: MEDCIN:313022
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:G5570
database_cross_reference: SNM:D-7122
database_cross_reference: SNMI:D6-94710
database_cross_reference: SNOMEDCT_US:16573007
database_cross_reference: SNOMEDCT_VET:318301000009103

Cerebral amyloid angiopathy
type: Class
subclass of: Amyloidosis
Definition: Amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system.
MCID: MC00043215
PMOID: PMO:00004243
Subclass_of: Amyloidosis
Synonym: Amyloid Angiopathy, Cerebral
Synonym: Angiopathy, Cerebral Amyloid
Synonym: Angiopathy, Congophilic
Synonym: CAA - Cerebral amyloid angiopathy
Synonym: CAA-Cerebr amyloid angiopath
Synonym: Cerebral Amyloid Angiopathies
Synonym: Cerebral Amyloid Angiopathy
Synonym: Cerebral Amyloid Angiopathy [Disease/Finding]
Synonym: Cerebral amyloid angiopathy (disorder)
Synonym: Congophilic Angiopathies
Tree Number: T3.6.24.3
database_cross_reference: CHV:0000015504
database_cross_reference: HPO:HP:0011970
database_cross_reference: ICD10:I68.0
database_cross_reference: ICD10AM:I68.0
database_cross_reference: ICD10CM:I68.0
database_cross_reference: MDR:10068044
database_cross_reference: MEDCIN:32182
database_cross_reference: MSH:D016657
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84625
database_cross_reference: NDFRT:N0000003453
database_cross_reference: OMIM:MTHU038754
database_cross_reference: RCD:X00Do
database_cross_reference: SNOMEDCT_US:195228000
database_cross_reference: SNOMEDCT_US:230724001

Conjunctival amyloidosis
type: Class
subclass of: Amyloidosis
Definition: A form of amyloidosis that affects the conjunctiva.
MCID: MC00092714
PMOID: PMO:00004244
Subclass_of: Amyloidosis
Synonym: Conjunctival amyloidosis (disorder)
Tree Number: T3.6.24.4
database_cross_reference: HPO:HP:0010637
database_cross_reference: RCD:X00Zv
database_cross_reference: SNMI:D6-94654
database_cross_reference: SNOMEDCT_US:59017008

Cutaneous amyloidosis
type: Class
subclass of: Amyloidosis
Definition: The presence of amyloid deposition in the superficial dermis.
MCID: MC00092709
PMOID: PMO:00004245
Subclass_of: Amyloidosis
Synonym: AD type amyloidosis
Synonym: AD type amyloidosis (disorder)
Synonym: Amyloid lichen
Synonym: Amyloidosis cutis
Synonym: Amyloidosis of dermis
Synonym: Amyloidosis of skin
Synonym: Amyloidosis of skin (disorder)
Synonym: Amyloidosis, Primary Cutaneous
Synonym: Cutaneous amyloidosis (disorder)
Synonym: Lichen amyloidosis
Tree Number: T3.6.24.5
database_cross_reference: CHV:0000026302
database_cross_reference: HPO:HP:0012309
database_cross_reference: ICD10:L99.0
database_cross_reference: ICD10AM:L99.0
database_cross_reference: MDR:10011659
database_cross_reference: MDR:10024427
database_cross_reference: MSH:C562642
database_cross_reference: RCD:M2y9.
database_cross_reference: SNM:M-55180
database_cross_reference: SNMI:D6-94640
database_cross_reference: SNOMEDCT_US:201337008
database_cross_reference: SNOMEDCT_US:281882003
database_cross_reference: SNOMEDCT_US:282834007
database_cross_reference: SNOMEDCT_US:61985005
database_cross_reference: SNOMEDCT_US:718105008

Generalized amyloid deposition
type: Class
subclass of: Amyloidosis
Definition: A diffuse form of amyloidosis.
MCID: MC01398503
PMOID: PMO:00004246
Subclass_of: Amyloidosis
Tree Number: T3.6.24.6
database_cross_reference: HPO:HP:0003216

Hepatic amyloidosis
type: Class
subclass of: Amyloidosis
Definition: A form of amyloidosis that affects the liver.
MCID: MC00092264
PMOID: PMO:00004247
Subclass_of: Amyloidosis
Synonym: Amyloidosis of liver
Synonym: Amyloidosis, hepatic
Synonym: Hepatic amyloidosis (disorder)
Synonym: amyloid infiltration of liver
Synonym: amyloid infiltration of liver (diagnosis)
Synonym: amyloidosis liver
Synonym: hepatic amyloidosis
Tree Number: T3.6.24.7
database_cross_reference: CHV:0000026218
database_cross_reference: HPO:HP:0012280
database_cross_reference: MDR:10075251
database_cross_reference: MEDCIN:312146
database_cross_reference: OMIM:MTHU024182
database_cross_reference: SNMI:D5-81840
database_cross_reference: SNOMEDCT_US:9551004
database_cross_reference: SNOMEDCT_VET:9551004

Renal amyloidosis
type: Class
subclass of: Amyloidosis
Definition: A form of amyloidosis that affects the kidney.
MCID: MC00092698
PMOID: PMO:00004248
Subclass_of: Amyloidosis
Synonym: Amyloid nephropathy
Synonym: Amyloid nephropathy (disorder)
Synonym: Lardaceous kidney
Synonym: Nephropathic amyloidosis
Synonym: Soapy kidney
Synonym: Waxy kidney
Synonym: amyloid nephropathy
Synonym: amyloid nephropathy (diagnosis)
Synonym: renal amyloidosis
Synonym: waxy kidney
Tree Number: T3.6.24.8
database_cross_reference: CHV:0000026300
database_cross_reference: HPO:HP:0001917
database_cross_reference: MDR:10038357
database_cross_reference: MEDCIN:30692
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU011698
database_cross_reference: RCD:C3736
database_cross_reference: SNMI:D6-94540
database_cross_reference: SNOMEDCT_US:48713002

Bloodstream infectious agent
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: The presence of an infectious agent in the blood circulation.
MCID: MC01397106
PMOID: PMO:00004249
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.25
database_cross_reference: HPO:HP:0031863

Bacteremia
type: Class
subclass of: Bloodstream infectious agent
Definition: Presence of viable bacteria in the blood.
MCID: MC00001466
PMOID: PMO:00004250
Subclass_of: Bloodstream infectious agent
Synonym: BACTEREMIA
Synonym: Bacteraemia
Synonym: Bacteraemia NOS
Synonym: Bacteraemia, unspecified
Synonym: Bacteremia (disorder)
Synonym: Bacteremia (finding)
Synonym: Bacteremia NOS
Synonym: Bacteremia NOS (disorder)
Synonym: Bacteremia NOS (finding)
Synonym: Bacteremia [Disease/Finding]
Tree Number: T3.6.25.1
database_cross_reference: BI:BI00698
database_cross_reference: CCPSS:1014114
database_cross_reference: CHV:0000001664
database_cross_reference: COSTAR:095
database_cross_reference: CSP:5003-0039
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0031864
database_cross_reference: ICD10CM:R78.81
database_cross_reference: ICD9CM:790.7
database_cross_reference: LCH_NW:sh85010812
database_cross_reference: MDR:10003997
database_cross_reference: MDR:10003998
database_cross_reference: MDR:10003999
database_cross_reference: MDR:10045641
database_cross_reference: MDR:10045642
database_cross_reference: MDR:10060562
database_cross_reference: MEDCIN:30872
database_cross_reference: MEDLINEPLUS:3210
database_cross_reference: MSH:D016470
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:790.7
database_cross_reference: NCI:C102993
database_cross_reference: NCI_NICHD:C102993
database_cross_reference: NDFRT:N0000003416
database_cross_reference: RCD:R106.
database_cross_reference: RCD:Xa3aY
database_cross_reference: RCD:XaD2L
database_cross_reference: RCDAE:R106.
database_cross_reference: RCDAE:Xa3aY
database_cross_reference: RCDAE:XaD2L
database_cross_reference: RCDSY:R106.
database_cross_reference: SNM:F-01130
database_cross_reference: SNMI:DE-10008
database_cross_reference: SNOMEDCT_US:10001005
database_cross_reference: SNOMEDCT_US:158561001
database_cross_reference: SNOMEDCT_US:207294007
database_cross_reference: SNOMEDCT_US:311773008
database_cross_reference: SNOMEDCT_US:5758002

Delayed oxidation of acetaldehyde
type: Class
subclass of: Abnormality of metabolism/homeostasis
MCID: MC01397756
PMOID: PMO:00004251
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.26
database_cross_reference: HPO:HP:0003533

Food intolerance
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.
MCID: MC00057872
PMOID: PMO:00004252
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Food intolerance (disorder)
Synonym: Malabsorption due to food intolerance
Synonym: Non-allergic food hypersensitivity
Synonym: malabsorption syndrome due to intolerance
Synonym: malabsorption syndrome due to intolerance (diagnosis)
Tree Number: T3.6.27
database_cross_reference: HPO:HP:0012537
database_cross_reference: MDR:10061958
database_cross_reference: MEDCIN:319169
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X3039
database_cross_reference: SNOMEDCT_US:235719002

Intolerance to protein
type: Class
subclass of: Food intolerance
MCID: MC00119529
PMOID: PMO:00004253
Subclass_of: Food intolerance
Synonym: Malabsorption caused by intolerance to protein
Synonym: Malabsorption caused by intolerance to protein (disorder)
Synonym: Malabsorption due to intolerance to protein
Synonym: Malabsorption due to intolerance to protein (disorder)
Tree Number: T3.6.27.1
database_cross_reference: ICD10CM:K90.49
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:Xa9CB
database_cross_reference: SNOMEDCT_US:302921006

Glutathione synthetase deficiency
type: Class
subclass of: Abnormality of metabolism/homeostasis
MCID: MC00140435
PMOID: PMO:00004255
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: 5 oxoprolinuria
Synonym: 5-OXOPROLINURIA
Synonym: 5-Oxoprolinuria
Synonym: 5-oxoprolinemia
Synonym: 5-oxoprolinuria
Synonym: Deficiency of Glutathione Synthase
Synonym: Deficiency of Glutathione Synthetase
Synonym: Deficiency of glutathione synthase
Synonym: Deficiency of glutathione synthase (disorder)
Synonym: Deficiency of glutathione synthetase
Tree Number: T3.6.28
database_cross_reference: CHV:0000026319
database_cross_reference: HPO:HP:0003343
database_cross_reference: MEDCIN:354196
database_cross_reference: MSH:C536835
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C128193
database_cross_reference: OMIM:266130
database_cross_reference: OMIM:601002
database_cross_reference: RCD:X20Hm
database_cross_reference: RCD:X40SC
database_cross_reference: RCDAE:X40SC
database_cross_reference: SNMI:D6-A3510
database_cross_reference: SNOMEDCT_US:124706000
database_cross_reference: SNOMEDCT_US:234589002
database_cross_reference: SNOMEDCT_US:39112005

Hyperbilirubinemia
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An increased amount of bilirubin in the blood.
MCID: MC00006528
PMOID: PMO:00004256
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: BILIRUBINAEMIA
Synonym: BILIRUBINEMIA
Synonym: Bilirubinaemia
Synonym: Bilirubinemia
Synonym: Bilirubinemia, NOS
Synonym: Bilirubinemias
Synonym: Disorder characterized by elevated serum bilirubin
Synonym: HYPERBILIRUBINEMIA
Synonym: High blood bilirubin levels
Synonym: Hyper bilirubinaemia
Tree Number: T3.6.29
database_cross_reference: AOD:0000005794
database_cross_reference: CHV:0000006402
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1653-7010
database_cross_reference: CST:BILIRUBINEM
database_cross_reference: DO:DOID:2741
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0002904
database_cross_reference: LCH:U002301
database_cross_reference: LCH_NW:sh85063672
database_cross_reference: MDR:10004702
database_cross_reference: MDR:10004705
database_cross_reference: MDR:10020551
database_cross_reference: MDR:10020578
database_cross_reference: MDR:10020582
database_cross_reference: MEDCIN:273599
database_cross_reference: MSH:D006932
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000255
database_cross_reference: MTH:U000288
database_cross_reference: MTH:U000343
database_cross_reference: MTH:U000372
database_cross_reference: NDFRT:N0000001575
database_cross_reference: RCD:44E2.
database_cross_reference: RCD:X307e
database_cross_reference: RCDAE:X307e
database_cross_reference: SNM:F-15003
database_cross_reference: SNMI:D6-84005
database_cross_reference: SNMI:D6-84380
database_cross_reference: SNOMEDCT_US:143932000
database_cross_reference: SNOMEDCT_US:14783006
database_cross_reference: SNOMEDCT_US:154770008
database_cross_reference: SNOMEDCT_US:166612004
database_cross_reference: SNOMEDCT_US:20505009
database_cross_reference: SNOMEDCT_US:235904007
database_cross_reference: SNOMEDCT_US:267509000
database_cross_reference: SNOMEDCT_VET:14783006
database_cross_reference: SNOMEDCT_VET:166612004

Conjugated hyperbilirubinemia
type: Class
subclass of: Hyperbilirubinemia
MCID: MC00092638
PMOID: PMO:00004257
Subclass_of: Hyperbilirubinemia
Synonym: Conjugated Hyperbilirubinemia
Synonym: Conjugated hyperbilirubinaemia
Synonym: Conjugated hyperbilirubinemia (disorder)
Synonym: Conjugated hyperbilirubinemia, NOS
Synonym: Direct Hyperbilirubinemia
Synonym: Direct hyperbilirubinaemia
Synonym: Direct hyperbilirubinemia
Synonym: Hyperbilirubinemia, conjugated
Synonym: Hyperbilirubinemia, direct
Synonym: conjugated hyperbilirubinemia
Tree Number: T3.6.29.1
database_cross_reference: CHV:0000026291
database_cross_reference: HPO:HP:0002908
database_cross_reference: MDR:10075815
database_cross_reference: MDR:10075821
database_cross_reference: MEDCIN:362610
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C113768
database_cross_reference: NCI_NICHD:C113768
database_cross_reference: OMIM:MTHU009469
database_cross_reference: OMIM:MTHU024631
database_cross_reference: OMIM:MTHU032108
database_cross_reference: RCD:X307k
database_cross_reference: RCDAE:X307k
database_cross_reference: SNMI:D6-84200
database_cross_reference: SNOMEDCT_US:9326001

Increased total bilirubin
type: Class
subclass of: Hyperbilirubinemia
Definition: Increased concentration of total (conjugated and unconjugated) bilirubin in the blood.
MCID: MC01399231
PMOID: PMO:00004258
Subclass_of: Hyperbilirubinemia
Synonym: High bili total
Synonym: Increased bilirubin
Tree Number: T3.6.29.2
database_cross_reference: HPO:HP:0003573

Neonatal hyperbilirubinemia
type: Class
subclass of: Hyperbilirubinemia
Definition: A type of hyperbilirubinemia with neonatal onset.
MCID: MC00007133
PMOID: PMO:00004259
Subclass_of: Hyperbilirubinemia
Synonym: ICTERUS NEONATORUM
Synonym: Icterus neonatorum
Synonym: Icterus neonatorum unspecified
Synonym: Icterus neonatorum, unspecified
Synonym: Icterus neonatorum, unspecified (disorder)
Synonym: JAUNDICE NEONATAL
Synonym: Jaundice in baby
Synonym: Jaundice neonatal
Synonym: Jaundice of newborn
Synonym: Jaundice, Neonatal
Tree Number: T3.6.29.3
database_cross_reference: AOD:0000004961
database_cross_reference: CHV:0000006993
database_cross_reference: CHV:0000044108
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:JAUNDICE NEONAT
database_cross_reference: DO:DOID:2383
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0006579
database_cross_reference: ICD10:P59.9
database_cross_reference: ICD10AM:P59.9
database_cross_reference: ICD10CM:P59.9
database_cross_reference: ICPC2P:A94001
database_cross_reference: ICPC2P:A94010
database_cross_reference: LCH:U002535
database_cross_reference: LCH_NW:sh85069784
database_cross_reference: MDR:10021210
database_cross_reference: MDR:10023137
database_cross_reference: MDR:10023138
database_cross_reference: MDR:10023141
database_cross_reference: MDR:10028953
database_cross_reference: MEDCIN:95175
database_cross_reference: MSH:D007567
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:774.6
database_cross_reference: NCI:C99246
database_cross_reference: NCI_NICHD:C99246
database_cross_reference: NDFRT:N0000001716
database_cross_reference: OMIM:MTHU003015
database_cross_reference: OMIM:MTHU012768
database_cross_reference: RCD:Q4360
database_cross_reference: RCD:X70Ea
database_cross_reference: RCD:Xa7MW
database_cross_reference: SNM:M-57600
database_cross_reference: SNMI:D8-74500
database_cross_reference: SNMI:D8-74510
database_cross_reference: SNOMEDCT_US:111470007
database_cross_reference: SNOMEDCT_US:206474007
database_cross_reference: SNOMEDCT_US:276549000
database_cross_reference: SNOMEDCT_US:299968002
database_cross_reference: SNOMEDCT_US:30235009
database_cross_reference: SNOMEDCT_US:31482007
database_cross_reference: SNOMEDCT_US:387712008

Neonatal unconjugated hyperbilirubinemia
type: Class
subclass of: Hyperbilirubinemia
MCID: MC00174110
PMOID: PMO:00004260
Subclass_of: Hyperbilirubinemia
Synonym: Neonat unconj hyperbilirubin
Synonym: Neonatal unconjugated hyperbilirubinaemia
Synonym: Neonatal unconjugated hyperbilirubinemia (disorder)
Tree Number: T3.6.29.4
database_cross_reference: HPO:HP:0008176
database_cross_reference: RCD:Xa1op
database_cross_reference: RCDAE:Xa1op
database_cross_reference: SNOMEDCT_US:281611002

Unconjugated hyperbilirubinemia
type: Class
subclass of: Hyperbilirubinemia
Definition: An increased amount of unconjugated (indirect) bilurubin in the blood.
MCID: MC00092637
PMOID: PMO:00004261
Subclass_of: Hyperbilirubinemia
Synonym: Hyperbilirubinemia, unconjugated
Synonym: Indirect Hyperbilirubinemia
Synonym: Indirect hyperbilirubinaemia
Synonym: Indirect hyperbilirubinemia
Synonym: Unconjd hyperbilirubinaemia
Synonym: Unconjd hyperbilirubinemia
Synonym: Unconjugated Hyperbilirubinemia
Synonym: Unconjugated hyperbilirubinaemia
Synonym: Unconjugated hyperbilirubinemia (disorder)
Synonym: Unconjugated hyperbilirubinemia, NOS
Tree Number: T3.6.29.5
database_cross_reference: CHV:0000026290
database_cross_reference: HPO:HP:0008282
database_cross_reference: MDR:10075817
database_cross_reference: MDR:10075822
database_cross_reference: MEDCIN:362611
database_cross_reference: NCI:C113785
database_cross_reference: NCI_NICHD:C113785
database_cross_reference: OMIM:MTHU037532
database_cross_reference: RCD:X307f
database_cross_reference: RCDAE:X307f
database_cross_reference: SNMI:D6-84100
database_cross_reference: SNOMEDCT_US:7752002

Increased level of propylene glycol in blood
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: An increase in the level of propylene glycol in the blood.
MCID: MC01399129
PMOID: PMO:00004262
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Increased level of propane-1,2-diol in blood
Tree Number: T3.6.30
database_cross_reference: HPO:HP:0410069

Ketosis
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: Presence of elevated levels of ketone bodies in the body.
MCID: MC00007235
PMOID: PMO:00004263
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: High levels of ketone bodies
Synonym: KETOSIS
Synonym: Ketoacidoses
Synonym: Ketoacidosis
Synonym: Ketosis (disorder)
Synonym: Ketosis [Disease/Finding]
Synonym: Ketosis, NOS
Synonym: ketosis
Tree Number: T3.6.31
database_cross_reference: CCPSS:1006662
database_cross_reference: CHV:0000007081
database_cross_reference: CST:KETOSIS
database_cross_reference: HPO:HP:0001946
database_cross_reference: ICPC2P:T99076
database_cross_reference: MDR:10023391
database_cross_reference: MSH:D007662
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000292
database_cross_reference: MTH:U000380
database_cross_reference: NDFRT:N0000001745
database_cross_reference: OMIM:MTHU011496
database_cross_reference: RCD:Xa9zp
database_cross_reference: SNMI:D6-23410
database_cross_reference: SNOMEDCT_US:2538008

Ketoacidosis
type: Class
subclass of: Ketosis
Definition: Acidosis resulting from accumulation of ketone bodies.
MCID: MC00007235
PMOID: PMO:00004264
Subclass_of: Ketosis
Synonym: High levels of ketone bodies
Synonym: KETOSIS
Synonym: Ketoacidoses
Synonym: Ketosis
Synonym: Ketosis (disorder)
Synonym: Ketosis [Disease/Finding]
Synonym: Ketosis, NOS
Synonym: ketosis
Tree Number: T3.6.31.1
database_cross_reference: CCPSS:1006662
database_cross_reference: CHV:0000007081
database_cross_reference: CST:KETOSIS
database_cross_reference: HPO:HP:0001946
database_cross_reference: ICPC2P:T99076
database_cross_reference: MDR:10023391
database_cross_reference: MSH:D007662
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000292
database_cross_reference: MTH:U000380
database_cross_reference: NDFRT:N0000001745
database_cross_reference: OMIM:MTHU011496
database_cross_reference: RCD:Xa9zp
database_cross_reference: SNMI:D6-23410
database_cross_reference: SNOMEDCT_US:2538008

Ketonemia
type: Class
subclass of: Ketosis
Definition: An increase in the level of ketone bodies in the blood.
MCID: MC00080014
PMOID: PMO:00004267
Subclass_of: Ketosis
Synonym: Acetonemia
Synonym: Acetonemias
Synonym: Increased level of ketone bodies in blood
Synonym: Increased serum ketones
Synonym: KETONEMIA
Synonym: Ketoacidemia
Synonym: Ketoacidemias
Synonym: Ketonaemia
Synonym: Ketonemia (disorder)
Synonym: Ketonemia (disorder) [Ambiguous]
Tree Number: T3.6.31.2
database_cross_reference: CCPSS:0047892
database_cross_reference: CHV:0000023533
database_cross_reference: HPO:HP:0001946
database_cross_reference: HPO:HP:0410175
database_cross_reference: MDR:10057592
database_cross_reference: MDR:10057599
database_cross_reference: MSH:D007662
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU012717
database_cross_reference: OMIM:MTHU020021
database_cross_reference: SNMI:D6-23406
database_cross_reference: SNOMEDCT_US:213281004
database_cross_reference: SNOMEDCT_US:45317003
database_cross_reference: SNOMEDCT_VET:313041000009106

Molybdenum cofactor deficiency
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: Absence of molybdenum cofactor(2-), a cofactor for enzymes including sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase.
MCID: MC00092506
PMOID: PMO:00004268
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Comb molybdoflavoprot enz def
Synonym: Comb xan ox & aldehyde ox def
Synonym: Comb xan ox & sulp ox & ald ox
Synonym: Combined molybdoflavoprotein enzyme deficiency
Synonym: Combined molybdoflavoprotein enzyme deficiency (disorder)
Synonym: Combined xanthine oxid & sulph oxid & aldehyde oxidase def
Synonym: Combined xanthine oxidase and aldehyde oxidase deficiency
Synonym: Combined xanthine oxidase and aldehyde oxidase deficiency (disorder)
Synonym: Combined xanthine oxidase and sulfite oxidase and aldehyde oxidase deficiency
Synonym: Combined xanthine oxidase and sulphite oxidase and aldehyde oxidase deficiency
Tree Number: T3.6.32
database_cross_reference: HPO:HP:0003570
database_cross_reference: MDR:10069687
database_cross_reference: MSH:C535811
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C129076
database_cross_reference: OMIM:252150
database_cross_reference: OMIM:MTHU042064
database_cross_reference: RCD:X40Ue
database_cross_reference: RCD:X40Uf
database_cross_reference: RCDAE:X40Uf
database_cross_reference: SNMI:D6-40520
database_cross_reference: SNOMEDCT_US:238008009
database_cross_reference: SNOMEDCT_US:29692004

Presence of xenobiotic
type: Class
subclass of: Abnormality of metabolism/homeostasis
Definition: Presence of a chemical substance found within an individual that is not naturally produced or expected to be present in human tissues or bodily fluids.
MCID: MC01400543
PMOID: PMO:00004269
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: The presence of a xenobiotic in body tissues or fluids can be the result of ingestion of or exposure to substances such as drugs, environmental pollutants, food additives, hydrocarbons, and pesticides.
Tree Number: T3.6.33
database_cross_reference: HPO:HP:0031838

Blood xenobiotic
type: Class
subclass of: Presence of xenobiotic
Definition: The presence of a xenobiotic in blood.
MCID: MC01397105
PMOID: PMO:00004270
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.1
database_cross_reference: HPO:HP:0410172

Gastric fluid xenobiotic
type: Class
subclass of: Presence of xenobiotic
Definition: Presence of a xenobiotic in gastric fluid.
MCID: MC01398492
PMOID: PMO:00004275
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.2
database_cross_reference: HPO:HP:0500101

Hair xenobiotic
type: Class
subclass of: Presence of xenobiotic
Definition: Presence of xenobiotic in hair.
MCID: MC01398573
PMOID: PMO:00004277
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.3
database_cross_reference: HPO:HP:0500099

Stool xenobiotic
type: Class
subclass of: Presence of xenobiotic
Definition: Presence of xenobiotic in stool.
MCID: MC01401321
PMOID: PMO:00004279
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.4
database_cross_reference: HPO:HP:0500097

Urine xenobiotic
type: Class
subclass of: Presence of xenobiotic
Definition: The presence of a xenobiotic in urine.
MCID: MC01401712
PMOID: PMO:00004283
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.5
database_cross_reference: HPO:HP:0031840

Abnormality of prenatal development or birth
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities.
MCID: MC01003066
PMOID: PMO:00004292
Subclass_of: Phenotypic Abnormality
Tree Number: T3.7
database_cross_reference: HPO:HP:0001197

Abnormal delivery
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: An abnormality of the birth process.
MCID: MC00173049
PMOID: PMO:00004293
Subclass_of: Abnormality of prenatal development or birth
Synonym: Abnormal delivery (finding)
Synonym: Abnormal delivery (history)
Synonym: DELIVERY ABNORMAL
Synonym: peripartum history delivery abnormal
Tree Number: T3.7.1
database_cross_reference: CST:MATFETDEL
database_cross_reference: HPO:HP:0001787
database_cross_reference: MEDCIN:129372
database_cross_reference: RCD:XM0tc
database_cross_reference: SNOMEDCT_US:156251002
database_cross_reference: SNOMEDCT_US:267352004
database_cross_reference: SNOMEDCT_US:274127000

Breech presentation
type: Class
subclass of: Abnormal delivery
Definition: A position of the fetus at delivery in which the fetus enters the birth canal with the buttocks or feet first.
MCID: MC00001932
PMOID: PMO:00004294
Subclass_of: Abnormal delivery
Synonym: BREECH PRESENTATION
Synonym: Breech Fetal Presentation
Synonym: Breech Labor Presentation
Synonym: Breech Presentation
Synonym: Breech Presentation [Disease/Finding]
Synonym: Breech delivery
Synonym: Breech delivery (disorder)
Synonym: Breech presentation (disorder)
Synonym: Breech presentation (finding)
Synonym: Breech presentation NOS
Tree Number: T3.7.1.1
database_cross_reference: CCPSS:0063154
database_cross_reference: CHV:0000002161
database_cross_reference: DXP:U000476
database_cross_reference: HPO:HP:0001623
database_cross_reference: HPO:HP:0010859
database_cross_reference: HPO:HP:0010860
database_cross_reference: HPO:HP:0010861
database_cross_reference: MDR:10006356
database_cross_reference: MEDCIN:291676
database_cross_reference: MEDCIN:34291
database_cross_reference: MEDCIN:9456
database_cross_reference: MSH:D001946
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34438
database_cross_reference: NCI_NICHD:C34438
database_cross_reference: NDFRT:N0000011068
database_cross_reference: OMIM:MTHU000028
database_cross_reference: OMIM:MTHU006183
database_cross_reference: RCD:L2220
database_cross_reference: RCD:L222z
database_cross_reference: RCD:X76TN
database_cross_reference: RCD:XE0w1
database_cross_reference: SNM:F-34280
database_cross_reference: SNMI:F-87280
database_cross_reference: SNOMEDCT_US:156157009
database_cross_reference: SNOMEDCT_US:156257003
database_cross_reference: SNOMEDCT_US:199352000
database_cross_reference: SNOMEDCT_US:199353005
database_cross_reference: SNOMEDCT_US:199356002
database_cross_reference: SNOMEDCT_US:249101006
database_cross_reference: SNOMEDCT_US:6096002

Caesarian section
type: Class
subclass of: Abnormal delivery
Definition: Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy).
MCID: MC01397201
PMOID: PMO:00004298
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.2
database_cross_reference: HPO:HP:0011410

Delivery by Odon device
type: Class
subclass of: Abnormal delivery
Definition: The Odon device is an instrument for assisted vaginal deliveries that is applied on the head of the baby and used to apply traction to assist the birth process.
MCID: MC01397770
PMOID: PMO:00004301
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.3
database_cross_reference: HPO:HP:0030366

Forceps delivery
type: Class
subclass of: Abnormal delivery
MCID: MC01398419
PMOID: PMO:00004302
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.4
database_cross_reference: HPO:HP:0011411

Induced vaginal delivery
type: Class
subclass of: Abnormal delivery
Definition: Vaginal delivery following induction of labor, a procedure used to stimulate uterine contractions during pregnancy before labor begins on its own.
MCID: MC01019073
PMOID: PMO:00004303
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.5
database_cross_reference: HPO:HP:0030369

Nuchal cord
type: Class
subclass of: Abnormal delivery
Definition: A complication of pregnancy and delivery in which the umbilical cord wraps around the fetal neck once or multiple times.
MCID: MC01400043
PMOID: PMO:00004304
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.6
database_cross_reference: HPO:HP:0012498

Premature rupture of membranes
type: Class
subclass of: Abnormal delivery
Definition: Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor.
MCID: MC00005079
PMOID: PMO:00004305
Subclass_of: Abnormal delivery
Synonym: Fetal Membranes, Premature Rupture
Synonym: Fetal Membranes, Premature Rupture [Disease/Finding]
Synonym: Fetal membranes, premature rupture
Synonym: MEMBRANE RUPTURE PREMATURE
Synonym: Membrane Premature Rupture (Pregnancy)
Synonym: Membrane Premature Ruptures (Pregnancy)
Synonym: Membrane-prem. rupture
Synonym: PROM
Synonym: PROM (Pregnancy)
Synonym: PROM - Prem rupt membranes
Tree Number: T3.7.1.7
database_cross_reference: CCPSS:0043301
database_cross_reference: CHV:0000004997
database_cross_reference: HPO:HP:0001788
database_cross_reference: ICD10:O42
database_cross_reference: ICD10:O42.9
database_cross_reference: ICD10AM:O42
database_cross_reference: ICD10AM:O42.9
database_cross_reference: ICD10CM:O42
database_cross_reference: ICD9CM:658.1
database_cross_reference: ICPC2P:W84027
database_cross_reference: LNC:LA20068-5
database_cross_reference: LNC:LA21777-0
database_cross_reference: MDR:10036603
database_cross_reference: MEDCIN:34308
database_cross_reference: MSH:D005322
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87113
database_cross_reference: NCI_NICHD:C87113
database_cross_reference: NDFRT:N0000001237
database_cross_reference: OMIM:MTHU037411
database_cross_reference: RCD:L281.
database_cross_reference: RCD:L2810
database_cross_reference: RCD:L281z
database_cross_reference: RCD:X40Bg
database_cross_reference: SNM:F-31830
database_cross_reference: SNMI:D8-22120
database_cross_reference: SNOMEDCT_US:156189000
database_cross_reference: SNOMEDCT_US:156191008
database_cross_reference: SNOMEDCT_US:157050000
database_cross_reference: SNOMEDCT_US:199657001
database_cross_reference: SNOMEDCT_US:199663005
database_cross_reference: SNOMEDCT_US:237266003
database_cross_reference: SNOMEDCT_US:267338001
database_cross_reference: SNOMEDCT_US:44223004

Shoulder dystocia
type: Class
subclass of: Abnormal delivery
Definition: Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex.
MCID: MC00093811
PMOID: PMO:00004307
Subclass_of: Abnormal delivery
Synonym: Impacted shoulders
Synonym: Impacted shoulders during labor
Synonym: SHOULDER DYSTOCIA
Synonym: SHOULDER DYSTOCIA UNSPECIFIED
Synonym: Shoulder (girdle) dystocia during labor and delivery
Synonym: Shoulder (girdle) dystocia during labour and delivery
Synonym: Shoulder Dystocia
Synonym: Shoulder dystocia NOS
Synonym: Shoulder dystocia NOS (disorder)
Synonym: Shoulder dystocia unspecified
Tree Number: T3.7.1.8
database_cross_reference: CCPSS:0019883
database_cross_reference: CCPSS:0043691
database_cross_reference: CHV:0000026443
database_cross_reference: HPO:HP:0011413
database_cross_reference: ICD10CM:O66.0
database_cross_reference: ICD9CM:660.4
database_cross_reference: LCH_NW:sh90006064
database_cross_reference: MDR:10040605
database_cross_reference: MDR:10040606
database_cross_reference: MDR:10040613
database_cross_reference: MEDCIN:35355
database_cross_reference: MTHICD9:660.4
database_cross_reference: NCI:C81290
database_cross_reference: NCI_NICHD:C81290
database_cross_reference: RCD:L305.
database_cross_reference: RCD:L3050
database_cross_reference: RCD:L305z
database_cross_reference: SNMI:D8-30142
database_cross_reference: SNOMEDCT_US:199782009
database_cross_reference: SNOMEDCT_US:199785006
database_cross_reference: SNOMEDCT_US:89700002

Spontaneous abortion
type: Class
subclass of: Abnormal delivery
Definition: A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 20th week of pregnancy.
MCID: MC00000136
PMOID: PMO:00004308
Subclass_of: Abnormal delivery
Synonym: ABORTION SPONTANEOUS
Synonym: ABORTION, SPONTANEOUS
Synonym: Abortion (Spontaneous)
Synonym: Abortion - spontaneous
Synonym: Abortion spontaneous
Synonym: Abortion spontaneous NOS
Synonym: Abortion, Spontaneous
Synonym: Abortion, Spontaneous [Disease/Finding]
Synonym: Abortion, spontaneous
Synonym: Abortion;spontaneous
Tree Number: T3.7.1.9
database_cross_reference: AOD:0000004923
database_cross_reference: AOD:0000023198
database_cross_reference: CCPSS:0043536
database_cross_reference: CHV:0000000546
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000638
database_cross_reference: CSP:2404-4325
database_cross_reference: CST:ABORTION
database_cross_reference: DO:DOID:722
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000006
database_cross_reference: HPO:HP:0005268
database_cross_reference: ICD10:O03
database_cross_reference: ICD10AM:O03
database_cross_reference: ICD10CM:O03
database_cross_reference: ICD10CM:O03.9
database_cross_reference: ICD9CM:634
database_cross_reference: ICPC2EENG:W82
database_cross_reference: ICPC2P:W82001
database_cross_reference: ICPC2P:W82004
database_cross_reference: LCH_NW:sh85085974
database_cross_reference: LNC:LA14272-1
database_cross_reference: LNC:MTHU002836
database_cross_reference: MDR:10000234
database_cross_reference: MDR:10000235
database_cross_reference: MDR:10000241
database_cross_reference: MDR:10027649
database_cross_reference: MDR:10027650
database_cross_reference: MDR:10041687
database_cross_reference: MEDCIN:30604
database_cross_reference: MEDLINEPLUS:515
database_cross_reference: MSH:D000022
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:761.8
database_cross_reference: NCI:C34336
database_cross_reference: NCI_FDA:1962
database_cross_reference: NCI_GAIA:C34336
database_cross_reference: NCI_NICHD:C34336
database_cross_reference: NDFRT:N0000000268
database_cross_reference: PSY:00100
database_cross_reference: PSY:31670
database_cross_reference: PSY:49350
database_cross_reference: RCD:L04..
database_cross_reference: RCD:L040.
database_cross_reference: RCD:L040z
database_cross_reference: RCD:L04z.
database_cross_reference: SNM:F-31600
database_cross_reference: SNM:F-31680
database_cross_reference: SNMI:D8-04100
database_cross_reference: SNOMEDCT_US:156071003
database_cross_reference: SNOMEDCT_US:156074006
database_cross_reference: SNOMEDCT_US:17369002
database_cross_reference: SNOMEDCT_US:198631006
database_cross_reference: SNOMEDCT_US:198643007
database_cross_reference: SNOMEDCT_US:198689000
database_cross_reference: SNOMEDCT_US:267294003

Therapeutic abortion
type: Class
subclass of: Abnormal delivery
Definition: Delivery by means of therapeutic termination of pregnancy. Therapeutic abortion may be done to end a pregnancy if the mother's life is in danger or if the baby has abnormalities involving the major organ systems and is not expected to survive after birth or by choice.
MCID: MC00231835
PMOID: PMO:00004310
Subclass_of: Abnormal delivery
Synonym: Therapeutic Abortion with Complications
Tree Number: T3.7.1.10
database_cross_reference: HPO:HP:0030449
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:D8-04202

Vaginal birth after Caesarian
type: Class
subclass of: Abnormal delivery
Definition: Vaginal birth after Caesarian (VBAC) refers to the situation where the mother has had a previous Cesarean delivery but has now delivered vaginally.
MCID: MC01401718
PMOID: PMO:00004311
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.11
database_cross_reference: HPO:HP:0030365

Ventouse delivery
type: Class
subclass of: Abnormal delivery
Definition: Delivery of newborn by means of a ventouse, a vacuum device used to assist the delivery of a baby when the second stage of labour has not progressed adequately.
MCID: MC01401731
PMOID: PMO:00004312
Subclass_of: Abnormal delivery
Synonym: Vacuum extraction
Synonym: Vacuum-assisted vaginal delivery
Tree Number: T3.7.1.12
database_cross_reference: HPO:HP:0011412

Abnormalities of placenta or umbilical cord
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: An abnormality of the placenta (the organ that connects the developing fetus to the uterine wall) or of the umbilical cord (the cord that connects the fetus to the placenta).
MCID: MC01003067
PMOID: PMO:00004313
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.2
database_cross_reference: HPO:HP:0001194

Abnormality of placental membranes
type: Class
subclass of: Abnormalities of placenta or umbilical cord
MCID: MC01001404
PMOID: PMO:00004314
Subclass_of: Abnormalities of placenta or umbilical cord
Tree Number: T3.7.2.1
database_cross_reference: HPO:HP:0011409

Abnormality of the placenta
type: Class
subclass of: Abnormalities of placenta or umbilical cord
Definition: An abnormality of the placenta, the organ that connects the developing fetus to the uterine wall to enable nutrient uptake, waste elimination, and gas exchange.
MCID: MC00442586
PMOID: PMO:00004318
Subclass_of: Abnormalities of placenta or umbilical cord
Synonym: 4-F3 ANOMALIES OF THE PLACENTA
Synonym: ANOMALIES OF THE PLACENTA
Synonym: Abnormal placenta
Synonym: Abnormal placenta NOS
Synonym: Abnormal placenta, NOS
Synonym: Abnormalities of Placenta
Synonym: Anomaly of placenta
Synonym: Anomaly of placenta (disorder)
Synonym: Anomaly of placenta, NOS
Synonym: PLACENTA ABNORMAL
Tree Number: T3.7.2.2
database_cross_reference: CCPSS:0023921
database_cross_reference: CHV:0000057943
database_cross_reference: COSTAR:NOCODE
database_cross_reference: HPO:HP:0100767
database_cross_reference: ICD10CM:O43.10
database_cross_reference: RCD:63D5.
database_cross_reference: SNM:M-29000
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-F3000
database_cross_reference: SNOMEDCT_US:147190007
database_cross_reference: SNOMEDCT_US:169957005
database_cross_reference: SNOMEDCT_US:33552005

Abnormality of the umbilical cord
type: Class
subclass of: Abnormalities of placenta or umbilical cord
Definition: An abnormality of the umbilical cord, which is the cord connecting the developing embryo or fetus to the placenta.
MCID: MC00091392
PMOID: PMO:00004328
Subclass_of: Abnormalities of placenta or umbilical cord
Synonym: 4-F5 ANOMALIES OF THE UMBILICAL CORD
Synonym: ANOMALIES OF THE UMBILICAL CORD
Synonym: Abnormal umbilical cord
Synonym: Abnormal umbilical cord (disorder)
Synonym: Abnormal umbilical cord, NOS
Synonym: Abnormalities of Umbilical Cord
Synonym: Umbilical cord abnormality
Synonym: Umbilical cord abnormality NOS
Synonym: Umbilical cord, abnormal
Synonym: abnormal cord umbilical
Tree Number: T3.7.2.3
database_cross_reference: CHV:0000026094
database_cross_reference: HPO:HP:0010881
database_cross_reference: MDR:10045446
database_cross_reference: MDR:10048596
database_cross_reference: MEDCIN:354830
database_cross_reference: MEDCIN:354831
database_cross_reference: SNM:M-29600
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-F5000
database_cross_reference: SNOMEDCT_US:90009001

Abnormality of the amniotic fluid
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: Abnormality of the amniotic fluid, which is the fluid contained in the amniotic sac surrounding the developing fetus.
MCID: MC01396370
PMOID: PMO:00004346
Subclass_of: Abnormality of prenatal development or birth
Synonym: Abnormal amniotic fluid
Tree Number: T3.7.3
database_cross_reference: HPO:HP:0001560

Fetal polyuria
type: Class
subclass of: Abnormality of the amniotic fluid
Definition: Abnormally increased production of urine by the fetus resulting in polyhydramnios.
MCID: MC01398316
PMOID: PMO:00004347
Subclass_of: Abnormality of the amniotic fluid
Tree Number: T3.7.3.1
database_cross_reference: HPO:HP:0001563

Meconium stained amniotic fluid
type: Class
subclass of: Abnormality of the amniotic fluid
Definition: Amniotic fluid containing the earliest stools of a mammalian infant.
MCID: MC01399719
PMOID: PMO:00004348
Subclass_of: Abnormality of the amniotic fluid
Synonym: Meconium staining of amniotic fluid
Synonym: Meconium-stained amniotic fluid
Tree Number: T3.7.3.2
database_cross_reference: HPO:HP:0012420

Oligohydramnios
type: Class
subclass of: Abnormality of the amniotic fluid
Definition: Diminished amniotic fluid volume in pregnancy.
MCID: MC00041195
PMOID: PMO:00004349
Subclass_of: Abnormality of the amniotic fluid
Synonym: Deficient liquor
Synonym: OLIGOHYDRAMNIOS
Synonym: Oligohydramnios (disorder)
Synonym: Oligohydramnios - delivered
Synonym: Oligohydramnios NOS
Synonym: Oligohydramnios NOS (disorder)
Synonym: Oligohydramnios [Disease/Finding]
Synonym: Oligohydramnios unspecified
Synonym: Oligohydramnios unspecified (disorder)
Synonym: Oligohydramnios, NOS
Tree Number: T3.7.3.3
database_cross_reference: CCPSS:0043700
database_cross_reference: CHV:0000015263
database_cross_reference: DO:DOID:12215
database_cross_reference: DXP:U002916
database_cross_reference: HPO:HP:0001562
database_cross_reference: ICD10:O41.0
database_cross_reference: ICD10AM:O41.0
database_cross_reference: ICD10CM:O41.0
database_cross_reference: ICD10CM:O41.00
database_cross_reference: ICD9CM:658.0
database_cross_reference: MDR:10030289
database_cross_reference: MEDCIN:34307
database_cross_reference: MSH:D016104
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92839
database_cross_reference: NCI_CDISC:C92839
database_cross_reference: NCI_NICHD:C92839
database_cross_reference: NDFRT:N0000003360
database_cross_reference: OMIM:MTHU036334
database_cross_reference: RCD:L280.
database_cross_reference: RCD:L2800
database_cross_reference: RCD:L280z
database_cross_reference: SNM:M-29440
database_cross_reference: SNMI:D8-22110
database_cross_reference: SNOMEDCT_US:156190009
database_cross_reference: SNOMEDCT_US:157051001
database_cross_reference: SNOMEDCT_US:199652007
database_cross_reference: SNOMEDCT_US:199656005
database_cross_reference: SNOMEDCT_US:59566000

Polyhydramnios
type: Class
subclass of: Abnormality of the amniotic fluid
Definition: The presence of excess amniotic fluid in the uterus during pregnancy.
MCID: MC00006437
PMOID: PMO:00004350
Subclass_of: Abnormality of the amniotic fluid
Synonym: Excessive liquor
Synonym: HYDRAMNIOS
Synonym: Hydramnios
Synonym: Hydrops amnii
Synonym: Hydrops amnion
Synonym: Hydrops of amnion
Synonym: Hydrops of amnion (diagnosis)
Synonym: Hydrops of amnion (disorder)
Synonym: POLYHYDRAMNIOS
Synonym: Polyhydramnios &/or hydramnios
Tree Number: T3.7.3.4
database_cross_reference: CCPSS:0042417
database_cross_reference: CHV:0000006333
database_cross_reference: CST:PREGN DIS
database_cross_reference: DO:DOID:8488
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000860
database_cross_reference: DXP:U002004
database_cross_reference: HPO:HP:0001561
database_cross_reference: ICD10:O40
database_cross_reference: ICD10AM:O40
database_cross_reference: ICD10CM:O40
database_cross_reference: ICD9CM:657
database_cross_reference: ICD9CM:657.0
database_cross_reference: ICPC2P:W84016
database_cross_reference: MDR:10020486
database_cross_reference: MDR:10036079
database_cross_reference: MEDCIN:34306
database_cross_reference: MEDCIN:360742
database_cross_reference: MSH:D006831
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:657
database_cross_reference: NCI:C92848
database_cross_reference: NCI_CDISC:C92848
database_cross_reference: NCI_NICHD:C92848
database_cross_reference: NDFRT:N0000001561
database_cross_reference: OMIM:MTHU036439
database_cross_reference: OMIM:MTHU037881
database_cross_reference: RCD:L270.
database_cross_reference: RCD:L2700
database_cross_reference: RCD:L270z
database_cross_reference: RCD:XE0wt
database_cross_reference: SNM:M-29450
database_cross_reference: SNMI:D8-22100
database_cross_reference: SNOMEDCT_US:156188008
database_cross_reference: SNOMEDCT_US:157052008
database_cross_reference: SNOMEDCT_US:199644009
database_cross_reference: SNOMEDCT_US:199645005
database_cross_reference: SNOMEDCT_US:199648007
database_cross_reference: SNOMEDCT_US:199650004
database_cross_reference: SNOMEDCT_US:267261001
database_cross_reference: SNOMEDCT_US:405235009
database_cross_reference: SNOMEDCT_US:86203003
database_cross_reference: SNOMEDCT_VET:405235009
database_cross_reference: SNOMEDCT_VET:86203003

Female fetal virilization
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: Fetal masculinization of female external genitalia.
MCID: MC01398308
PMOID: PMO:00004351
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.4
database_cross_reference: HPO:HP:0031170

Fetal distress
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: An intrauterine state characterized by suboptimal values in the fetal heart rate, oxygenation of fetal blood, or other parameters indicative of compromise of the fetus. Signs of fetal distress include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile.
MCID: MC00005070
PMOID: PMO:00004352
Subclass_of: Abnormality of prenatal development or birth
Synonym: Distress - fetal
Synonym: Distress, Fetal
Synonym: FETAL DISTRESS
Synonym: FOETAL DISTRESS
Synonym: Fetal Distress
Synonym: Fetal Distress [Disease/Finding]
Synonym: Fetal Intolerance of Labor
Synonym: Fetal Status, Nonreassuring
Synonym: Fetal distress (finding)
Synonym: Fetal distress NOS
Tree Number: T3.7.5
database_cross_reference: AOD:0000004920
database_cross_reference: CCPSS:1008189
database_cross_reference: CHV:0000004991
database_cross_reference: CST:FETAL DIS
database_cross_reference: CST:PERINATAL DIS
database_cross_reference: DO:DOID:4027
database_cross_reference: DXP:U001470
database_cross_reference: HPO:HP:0025116
database_cross_reference: LCH:U001772
database_cross_reference: LCH_NW:sh85047945
database_cross_reference: MDR:10016486
database_cross_reference: MDR:10016492
database_cross_reference: MDR:10016854
database_cross_reference: MDR:10016855
database_cross_reference: MDR:10042806
database_cross_reference: MDR:10055709
database_cross_reference: MSH:D005316
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C50563
database_cross_reference: NCI_FDA:1856
database_cross_reference: NCI_NICHD:C50563
database_cross_reference: NDFRT:N0000001234
database_cross_reference: OMIM:MTHU009786
database_cross_reference: RCD:L2630
database_cross_reference: RCD:L263z
database_cross_reference: RCD:Xa0kg
database_cross_reference: SNM:F-33020
database_cross_reference: SNOMEDCT_US:130955003
database_cross_reference: SNOMEDCT_US:157098009
database_cross_reference: SNOMEDCT_US:157103006
database_cross_reference: SNOMEDCT_US:199591006
database_cross_reference: SNOMEDCT_US:199604002
database_cross_reference: SNOMEDCT_US:267336002
database_cross_reference: SNOMEDCT_US:268873007

Fetal ultrasound soft marker
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: An finding upon obstetric ultrasound examination performed at around 16 to 20 weeks of gestation that is abnormal but not clearly identifiable as a fetal anatomic malformation or growth restriction. Such findings are known as soft markers since they are associated with increased risk for fetal aneuploidy or other disorders.
MCID: MC01398317
PMOID: PMO:00004353
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.6
database_cross_reference: HPO:HP:0011425

Absence of stomach bubble on fetal sonography
type: Class
subclass of: Fetal ultrasound soft marker
Definition: By the 14th week of gestation it is nearly always possible to visualized the fluid-filled fetal stomach bubble on prenatal sonography. This term refers to the absence of a normal fetal stomach bubble on fetal ultrasonography performed at around 16 to 20 weeks' gestation.
MCID: MC01396462
PMOID: PMO:00004354
Subclass_of: Fetal ultrasound soft marker
Tree Number: T3.7.6.1
database_cross_reference: HPO:HP:0010963

Echogenic fetal bowel
type: Class
subclass of: Fetal ultrasound soft marker
Definition: Echogenic bowel is defined as fetal bowel with homogenous areas of echogenicity that are equal to or greater than that of surrounding bone.
MCID: MC00797900
PMOID: PMO:00004355
Subclass_of: Fetal ultrasound soft marker
Synonym: Echogenic Bowel
Synonym: Echogenic Bowel [Disease/Finding]
Synonym: Echogenic Bowels
Synonym: Echogenic bowel
Synonym: Hyperechogenic Bowel
Synonym: Hyperechogenic Bowels
Tree Number: T3.7.6.2
database_cross_reference: HPO:HP:0010943
database_cross_reference: MSH:D058535
database_cross_reference: NDFRT:N0000182249

Enlarged fetal cisterna magna
type: Class
subclass of: Fetal ultrasound soft marker
Definition: The cisterna magna is measured on a transaxial view of the fetal head angled 15 degrees caudal to the canthomeatal line. The anterior/posterior diameter is taken between the inferior/posterior surface of the vemis of the cerebellum to the inner surface of the cranium. An enlarged cisternal magna is defined by an anterior/posterior diameter of 10 mm or more (pmid:16100637).
MCID: MC01398147
PMOID: PMO:00004356
Subclass_of: Fetal ultrasound soft marker
Tree Number: T3.7.6.3
database_cross_reference: HPO:HP:0011427

Fetal choroid plexus cysts
type: Class
subclass of: Fetal ultrasound soft marker
Definition: Fetal choroid plexus cysts (CPCs) are sonographically discrete, small cysts (3 mm or more) found in the choroid plexus within the lateral cerebral ventricles of the developing fetus at 14 to 24 weeks gestation. Imaging of the choroid plexus is performed in the transverse plane of the fetal head at the same level that the lateral cerebral ventricle is evaluated. The choroid plexus should be inspected bilaterally for the presence of cysts. The size of CPCs is not of clinical relevance (pmid:16100637).
MCID: MC01398314
PMOID: PMO:00004357
Subclass_of: Fetal ultrasound soft marker
Tree Number: T3.7.6.4
database_cross_reference: HPO:HP:0011426

Fetal fifth finger clinodactyly
type: Class
subclass of: Fetal ultrasound soft marker
Definition: Fifth finger clinodactyly is defined by a hypoplastic or absent mid-phalanx of the fifth digit. Ultrasound identification of the fetal hand must first be undertaken and then appropriate magnification accomplished. The evaluation requires stretching of the 5 fingers. The diagnosis is established when the middle phalanx of the fifth finger is markedly smaller than normal or absent, which often causes the finger to be curved inward (pmid:16100637).
MCID: MC01001402
PMOID: PMO:00004358
Subclass_of: Fetal ultrasound soft marker
Tree Number: T3.7.6.5
database_cross_reference: HPO:HP:0011431

Hypoplasia of fetal nasal bone
type: Class
subclass of: Fetal ultrasound soft marker
Definition: On prenatal ultrasound, the nasal bone is a thin echogenic line within the bridge of the fetal nose. The fetus is imaged facing the transducer with the fetal face strictly in the midline. The angle of insonation is 90 degrees, with the longitudinal axis of the nasal bone as the reference line. Calibres are placed at each end of the nasal bone. Absence of the nasal bone or measurements below 2.5th percentile are considered significant (pmid:16100637).
MCID: MC01398780
PMOID: PMO:00004359
Subclass_of: Fetal ultrasound soft marker
Synonym: Underdeveloped fetal nose bone
Tree Number: T3.7.6.6
database_cross_reference: HPO:HP:0011430

Short fetal femur length
type: Class
subclass of: Fetal ultrasound soft marker
Definition: A short femur length is defined as either a measurement below the 2.5th percentile for gestational age or a measurement that is less than 0.9 of that predicted by the measured biparietal diameter. The femur should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (pmid:16100637).
MCID: MC01401096
PMOID: PMO:00004360
Subclass_of: Fetal ultrasound soft marker
Synonym: Short fetal thigh bone length
Tree Number: T3.7.6.7
database_cross_reference: HPO:HP:0011428

Short fetal humerus length
type: Class
subclass of: Fetal ultrasound soft marker
Definition: A short humerus length is defined as a length below the 2.5th percentile for gestational age or as a measurement less than 0.9 of that predicted by the measured biparietal diameter. The humerus should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (pmid:16100637).
MCID: MC01001403
PMOID: PMO:00004361
Subclass_of: Fetal ultrasound soft marker
Synonym: Short fetal long bone in upper arm length
Tree Number: T3.7.6.8
database_cross_reference: HPO:HP:0011429

Intrauterine fetal demise of one twin after midgestation
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: Loss of one twin occurring after midgestation (17 weeks gestation).
MCID: MC01399349
PMOID: PMO:00004362
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.7
database_cross_reference: HPO:HP:0030753

Low APGAR score
type: Class
subclass of: Abnormality of prenatal development or birth
MCID: MC01399606
PMOID: PMO:00004363
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.8
database_cross_reference: HPO:HP:0030917

Low 1-minute APGAR score
type: Class
subclass of: Low APGAR score
MCID: MC01399599
PMOID: PMO:00004364
Subclass_of: Low APGAR score
Synonym: Low one-minute APGAR score
Tree Number: T3.7.8.1
database_cross_reference: HPO:HP:0030918

Low 5-minute APGAR score
type: Class
subclass of: Low APGAR score
MCID: MC01399600
PMOID: PMO:00004372
Subclass_of: Low APGAR score
Synonym: Low five-minute APGAR score
Tree Number: T3.7.8.2
database_cross_reference: HPO:HP:0030919

Postterm pregnancy
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: A pregnancy that extends to 42 weeks of gestation or beyond.
MCID: MC01400509
PMOID: PMO:00004380
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.9
database_cross_reference: HPO:HP:0031169

Premature birth
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: The birth of a baby of less than 37 weeks of gestational age.
MCID: MC01400527
PMOID: PMO:00004381
Subclass_of: Abnormality of prenatal development or birth
Synonym: Premature delivery
Synonym: Premature delivery of affected infants
Synonym: Preterm delivery
Synonym: Shortened gestation time
Tree Number: T3.7.10
database_cross_reference: HPO:HP:0001622

Premature delivery because of cervical insufficiency or membrane fragility
type: Class
subclass of: Premature birth
MCID: MC01400529
PMOID: PMO:00004382
Subclass_of: Premature birth
Tree Number: T3.7.10.1
database_cross_reference: HPO:HP:0005267

Prenatal maternal abnormality
type: Class
subclass of: Abnormality of prenatal development or birth
MCID: MC01002975
PMOID: PMO:00004383
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.11
database_cross_reference: HPO:HP:0002686

Abnormal maternal serum screening
type: Class
subclass of: Prenatal maternal abnormality
Definition: An abnormally elevated or decreased level of a maternal serum marker analytes used in screening for aneuploidy.
MCID: MC01395990
PMOID: PMO:00004384
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.1
database_cross_reference: HPO:HP:0011436

Ectopic pregnancy
type: Class
subclass of: Prenatal maternal abnormality
Definition: A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube).
MCID: MC00010583
PMOID: PMO:00004391
Subclass_of: Prenatal maternal abnormality
Synonym: 8-02 ECTOPIC PREGNANCIES
Synonym: ECTOPIC PREGN
Synonym: ECTOPIC PREGNANCIES
Synonym: ECTOPIC PREGNANCY
Synonym: EP - Ectopic pregnancy
Synonym: Eccyesis
Synonym: Ectopic Pregnancies
Synonym: Ectopic Pregnancy
Synonym: Ectopic pregnancy (disorder)
Synonym: Ectopic pregnancy NOS
Tree Number: T3.7.11.2
database_cross_reference: CCPSS:0058085
database_cross_reference: CCPSS:1017912
database_cross_reference: CHV:0000010065
database_cross_reference: COSTAR:U000217
database_cross_reference: CSP:2403-8709
database_cross_reference: CST:PREGN DIS
database_cross_reference: DO:DOID:0060329
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001067
database_cross_reference: HPO:HP:0031456
database_cross_reference: ICD10:O00
database_cross_reference: ICD10:O00.9
database_cross_reference: ICD10AM:O00
database_cross_reference: ICD10AM:O00.9
database_cross_reference: ICD10CM:O00
database_cross_reference: ICD10CM:O00.9
database_cross_reference: ICD10CM:O00.90
database_cross_reference: ICD9CM:633
database_cross_reference: ICD9CM:633.9
database_cross_reference: ICPC2EENG:W80
database_cross_reference: ICPC2P:W80001
database_cross_reference: LCH:U003806
database_cross_reference: LCH_NW:sh85106288
database_cross_reference: LNC:MTHU015326
database_cross_reference: MDR:10014166
database_cross_reference: MDR:10014169
database_cross_reference: MDR:10015765
database_cross_reference: MDR:10015865
database_cross_reference: MDR:10036559
database_cross_reference: MDR:10045857
database_cross_reference: MDR:10072039
database_cross_reference: MEDCIN:30600
database_cross_reference: MEDLINEPLUS:5811
database_cross_reference: MSH:D011271
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34945
database_cross_reference: NCI_FDA:1819
database_cross_reference: NCI_GAIA:C34945
database_cross_reference: NCI_NCI-GLOSS:CDR0000666673
database_cross_reference: NCI_NCI-GLOSS:CDR0000666674
database_cross_reference: NCI_NICHD:C34945
database_cross_reference: NDFRT:N0000002486
database_cross_reference: RCD:L03..
database_cross_reference: RCD:L03z.
database_cross_reference: SNM:F-31100
database_cross_reference: SNMI:D8-02000
database_cross_reference: SNOMEDCT_US:156080003
database_cross_reference: SNOMEDCT_US:156083001
database_cross_reference: SNOMEDCT_US:198630007
database_cross_reference: SNOMEDCT_US:34801009

Hyperemesis gravidarum
type: Class
subclass of: Prenatal maternal abnormality
Definition: Excessive vomiting in early pregnancy, leading to the loss of 5% or more of body weight.
MCID: MC00006536
PMOID: PMO:00004392
Subclass_of: Prenatal maternal abnormality
Synonym: Excess vomiting in pregnancy
Synonym: Excessive pregnancy vomiting
Synonym: Excessive vomiting in pregnancy
Synonym: Excessive vomiting in pregnancy (disorder)
Synonym: Gravidarum -hyperemesis
Synonym: HYPEREMESIS GRAVIDARUM
Synonym: Hyperemesis
Synonym: Hyperemesis Gravidarum
Synonym: Hyperemesis Gravidarum [Disease/Finding]
Synonym: Hyperemesis arising during pregnancy
Tree Number: T3.7.11.3
database_cross_reference: CCPSS:0051605
database_cross_reference: CHV:0000006410
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:9357
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000871
database_cross_reference: DXP:U002020
database_cross_reference: HPO:HP:0012188
database_cross_reference: ICD10:O21
database_cross_reference: ICD10AM:O21
database_cross_reference: ICD10CM:O21
database_cross_reference: ICD9CM:643
database_cross_reference: ICPC2P:W05004
database_cross_reference: MDR:10015592
database_cross_reference: MDR:10015609
database_cross_reference: MDR:10020614
database_cross_reference: MEDCIN:32392
database_cross_reference: MSH:D006939
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87084
database_cross_reference: NCI_NICHD:C87084
database_cross_reference: NDFRT:N0000001582
database_cross_reference: RCD:L13..
database_cross_reference: SNMI:D8-11510
database_cross_reference: SNOMEDCT_US:14094001
database_cross_reference: SNOMEDCT_US:156113005
database_cross_reference: SNOMEDCT_US:267308007

Maternal autoimmune disease
type: Class
subclass of: Prenatal maternal abnormality
Definition: A medical history of a fetus or child born to a mother with an autoimmune disease.
MCID: MC01001401
PMOID: PMO:00004393
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.4
database_cross_reference: HPO:HP:0011437

Maternal diabetes
type: Class
subclass of: Prenatal maternal abnormality
Definition: Maternal diabetes can either be a gestational, mostly type 2 diabetes, or a type 1 diabetes. Essential is the resulting maternal hyperglycemia as a non-specific teratogen, imposing the same risk of congenital malformations to pregnant women with both type 1 and type2 diabetes.
MCID: MC00043206
PMOID: PMO:00004395
Subclass_of: Prenatal maternal abnormality
Synonym: -- Gestational Diabetes
Synonym: DIABETES MELLITUS (GESTATIONAL)
Synonym: DIABETES MELLITUS GESTATIONAL
Synonym: DIABETES PREGN IND
Synonym: Diabetes Mellitus, Gestational
Synonym: Diabetes and Pregnancy
Synonym: Diabetes gestatational
Synonym: Diabetes in Pregnancy
Synonym: Diabetes mel aris in pregnancy
Synonym: Diabetes mellitus arising in pregnancy
Tree Number: T3.7.11.5
database_cross_reference: BI:BI00337
database_cross_reference: CCPSS:0037256
database_cross_reference: CHV:0000015496
database_cross_reference: CHV:0000049938
database_cross_reference: COSTAR:U000227
database_cross_reference: COSTAR:U000400
database_cross_reference: CSP:0862-6650
database_cross_reference: DO:DOID:11714
database_cross_reference: HPO:HP:0009800
database_cross_reference: ICD10:O24.4
database_cross_reference: ICD10AM:O24.4
database_cross_reference: ICD10CM:O24.4
database_cross_reference: ICPC2EENG:W85
database_cross_reference: ICPC2P:W77004
database_cross_reference: ICPC2P:W85001
database_cross_reference: LNC:LA10553-8
database_cross_reference: LNC:LA19979-6
database_cross_reference: MDR:10012606
database_cross_reference: MDR:10018209
database_cross_reference: MDR:10018210
database_cross_reference: MEDCIN:33909
database_cross_reference: MEDLINEPLUS:1408
database_cross_reference: MSH:D016640
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34942
database_cross_reference: NCI_NICHD:C34942
database_cross_reference: NDFRT:N0000003450
database_cross_reference: OMIM:MTHU004757
database_cross_reference: RCD:L1808
database_cross_reference: SNM:D-2403
database_cross_reference: SNM:D-2410
database_cross_reference: SNMI:DB-61400
database_cross_reference: SNOMEDCT_US:11687002
database_cross_reference: SNOMEDCT_US:199232003
database_cross_reference: SNOMEDCT_US:237629002
database_cross_reference: SNOMEDCT_US:359964007
database_cross_reference: SNOMEDCT_US:393568003

Maternal fever in pregnancy
type: Class
subclass of: Prenatal maternal abnormality
Definition: The occurence of an elevated body temperature of the mother during pregnancy.
MCID: MC01399710
PMOID: PMO:00004396
Subclass_of: Prenatal maternal abnormality
Synonym: Maternal fever during pregnancy
Tree Number: T3.7.11.6
database_cross_reference: HPO:HP:0030244

Maternal hyperphenylalaninemia
type: Class
subclass of: Prenatal maternal abnormality
Definition: A medical history of exposure during the fetal period to hyperphenylalaninemia because the mother had phenylketonuria with inadequate control during pregnancy.
MCID: MC01399712
PMOID: PMO:00004399
Subclass_of: Prenatal maternal abnormality
Synonym: High blood phenylalanine level in mother
Tree Number: T3.7.11.7
database_cross_reference: HPO:HP:0100610

Maternal seizures
type: Class
subclass of: Prenatal maternal abnormality
MCID: MC01399713
PMOID: PMO:00004400
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.8
database_cross_reference: HPO:HP:0100622

Maternal thrombophilia
type: Class
subclass of: Prenatal maternal abnormality
Definition: An increased tendency towards thrombosis in the mother during a pregnancy.
MCID: MC01399715
PMOID: PMO:00004401
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.9
database_cross_reference: HPO:HP:0040222

Maternal virilization in pregnancy
type: Class
subclass of: Prenatal maternal abnormality
Definition: Virilization (deepening of voice, facial hirsutism and scalp hair loss) with onset during pregnancy (usually towards the end of the first trimester) and regression several months post-partum.
MCID: MC01399716
PMOID: PMO:00004402
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.10
database_cross_reference: HPO:HP:0008072

Pregnancy exposure
type: Class
subclass of: Prenatal maternal abnormality
Definition: Exposure of pregnant women to toxins from any source, such as environmental toxins or chemicals, that may potentially cause problems such as miscarriage, preterm delivery, low birth weight, and, in some cases, developmental delays in infants.
MCID: MC01400524
PMOID: PMO:00004403
Subclass_of: Prenatal maternal abnormality
Synonym: Exposure during pregnancy
Tree Number: T3.7.11.11
database_cross_reference: HPO:HP:0031437

Skewed maternal X inactivation
type: Class
subclass of: Prenatal maternal abnormality
Definition: A deviation from equal (50%) inactivation of each parental X chromosome in maternal cells.
MCID: MC01001080
PMOID: PMO:00004405
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.12
database_cross_reference: HPO:HP:0012546

Toxemia of pregnancy
type: Class
subclass of: Prenatal maternal abnormality
Definition: Pregnancy-induced toxic reactions of the mother that can be as harmless as slight Maternal hypertension or as life threatening as Eclampsia.
MCID: MC01401530
PMOID: PMO:00004406
Subclass_of: Prenatal maternal abnormality
Synonym: Hypertensive disorder of pregnancy
Tree Number: T3.7.11.13
database_cross_reference: HPO:HP:0100603

Prenatal movement abnormality
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: An abnormality of fetal movement.
MCID: MC01400541
PMOID: PMO:00004410
Subclass_of: Abnormality of prenatal development or birth
Synonym: Abnormal intrauterine movements
Tree Number: T3.7.12
database_cross_reference: HPO:HP:0001557

Decreased fetal movement
type: Class
subclass of: Prenatal movement abnormality
Definition: An abnormal reduction in quantity or strength of fetal movements.
MCID: MC00080095
PMOID: PMO:00004411
Subclass_of: Prenatal movement abnormality
Synonym: Baby kicking less
Synonym: Baby moving less
Synonym: Decreased fetal activity
Synonym: Decreased fetal movements
Synonym: Decreased fetal movements, unsp trimester, unsp
Synonym: Decreased fetal movements, unspecified trimester, not applicable or unspecified
Synonym: Decreased movement in utero
Synonym: Decreased;fetal movement
Synonym: Decreased;foetal movement
Synonym: FETAL ACTIVITY DECREASE
Tree Number: T3.7.12.1
database_cross_reference: CCPSS:0060630
database_cross_reference: CHV:0000023576
database_cross_reference: DXP:U001466
database_cross_reference: HPO:HP:0001558
database_cross_reference: ICD10CM:O36.81
database_cross_reference: ICD10CM:O36.8190
database_cross_reference: ICPC2P:W29011
database_cross_reference: MDR:10016866
database_cross_reference: MDR:10054744
database_cross_reference: MDR:10068449
database_cross_reference: MDR:10068461
database_cross_reference: MEDCIN:281778
database_cross_reference: MEDCIN:296351
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU009012
database_cross_reference: OMIM:MTHU037032
database_cross_reference: OMIM:MTHU037783
database_cross_reference: OMIM:MTHU037915
database_cross_reference: OMIM:MTHU038242
database_cross_reference: OMIM:MTHU051295
database_cross_reference: RCD:Xa04B
database_cross_reference: SNOMEDCT_US:199633001
database_cross_reference: SNOMEDCT_US:276369006

Increased fetal movement
type: Class
subclass of: Prenatal movement abnormality
Definition: An abnormal increase in quantity or strength of fetal movements.
MCID: MC01399067
PMOID: PMO:00004413
Subclass_of: Prenatal movement abnormality
Synonym: Fetal hyperkinesia
Tree Number: T3.7.12.2
database_cross_reference: HPO:HP:0010519

Twin-to-twin transfusion
type: Class
subclass of: Abnormality of prenatal development or birth
Definition: As a result of sharing a single placenta, the blood supplies of monochorionic twin fetuses can become connected, so that they share blood circulation: although each fetus uses its own portion of the placenta, the connecting blood vessels within the placenta allow blood to pass from one twin to the other.Depending on the number, type and direction of the interconnecting blood vessels (anastomoses), blood can be transferred disproportionately from one twin (the donor) to the other (the recipient). This state of transfusion causes the donor twin to have decreased blood volume, retarding the donor's development and growth. The blood volume of the recipient twin is increased, which can strain the fetus's heart and eventually lead to heart failure.
MCID: MC01401602
PMOID: PMO:00004414
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.13
database_cross_reference: HPO:HP:0031110

Abnormality of the breast
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the breast.
MCID: MC01003091
PMOID: PMO:00004415
Subclass_of: Phenotypic Abnormality
Tree Number: T3.8
database_cross_reference: HPO:HP:0000769

Abnormal breast morphology
type: Class
subclass of: Abnormality of the breast
Definition: Any anomaly of the structure of the breast.
MCID: MC01395778
PMOID: PMO:00004416
Subclass_of: Abnormality of the breast
Tree Number: T3.8.1
database_cross_reference: HPO:HP:0031093

Abnormal nipple morphology
type: Class
subclass of: Abnormal breast morphology
Definition: An abnormality of the nipple.
MCID: MC01396027
PMOID: PMO:00004417
Subclass_of: Abnormal breast morphology
Synonym: Abnormality of the nipple
Tree Number: T3.8.1.1
database_cross_reference: HPO:HP:0004404

Aplasia/Hypoplasia of the breasts
type: Class
subclass of: Abnormal breast morphology
Definition: Absence or underdevelopment of the breasts.
MCID: MC01396837
PMOID: PMO:00004429
Subclass_of: Abnormal breast morphology
Synonym: Absent/small breasts
Synonym: Absent/underdeveloped breasts
Tree Number: T3.8.1.2
database_cross_reference: HPO:HP:0010311

Asymmetry of the breasts
type: Class
subclass of: Abnormal breast morphology
Definition: The presence of asymmetrical breasts.
MCID: MC00611956
PMOID: PMO:00004434
Subclass_of: Abnormal breast morphology
Synonym: ANISOMASTIA
Synonym: Anisomastia
Synonym: Breast asymmetry
Tree Number: T3.8.1.3
database_cross_reference: HPO:HP:0010312
database_cross_reference: MDR:10068732
database_cross_reference: MDR:10076298
database_cross_reference: MSH:C565299
database_cross_reference: OMIM:605746

Breast hypertrophy
type: Class
subclass of: Abnormal breast morphology
Definition: The presence of hypertrophy of the breast.
MCID: MC00006590
PMOID: PMO:00004435
Subclass_of: Abnormal breast morphology
Synonym: Breast Hypertrophy
Synonym: Hypertrophy - breast
Synonym: Hypertrophy breast
Synonym: Hypertrophy of Breast
Synonym: Hypertrophy of breast
Synonym: Hypertrophy of breast (disorder)
Synonym: Hypertrophy of breast NOS
Synonym: Hypertrophy of breast NOS (disorder)
Synonym: Hypertrophy of breast, NOS
Synonym: Hypertrophy of the Breast
Tree Number: T3.8.1.4
database_cross_reference: CHV:0000006457
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10688
database_cross_reference: HPO:HP:0010313
database_cross_reference: ICD10:N62
database_cross_reference: ICD10AM:N62
database_cross_reference: ICD10CM:N62
database_cross_reference: ICD9CM:611.1
database_cross_reference: MDR:10020881
database_cross_reference: MDR:10020885
database_cross_reference: MDR:10026733
database_cross_reference: MEDCIN:7100
database_cross_reference: MEDCIN:91891
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:611.1
database_cross_reference: NCI:C3125
database_cross_reference: RCD:K311.
database_cross_reference: RCD:K311z
database_cross_reference: SNMI:D7-90400
database_cross_reference: SNOMEDCT_US:155963008
database_cross_reference: SNOMEDCT_US:198114003
database_cross_reference: SNOMEDCT_US:266646002
database_cross_reference: SNOMEDCT_US:372281005
database_cross_reference: SNOMEDCT_US:43336006

Gynecomastia
type: Class
subclass of: Abnormal breast morphology
Definition: Abnormal development of large mammary glands in males resulting in breast enlargement.
MCID: MC00005892
PMOID: PMO:00004436
Subclass_of: Abnormal breast morphology
Synonym: BREAST ENLARGEMENT MALE
Synonym: Breast Enlargement, Male
Synonym: Breast enlargement male
Synonym: ENLARGEMENT BREAST MALE
Synonym: Enlargement breast male
Synonym: Enlargement, Male Breast
Synonym: GYNAECOMASTIA
Synonym: GYNECOMASTIA
Synonym: Gynaecomastia
Synonym: Gynaecomazia
Tree Number: T3.8.1.5
database_cross_reference: AOD:0000004462
database_cross_reference: BI:BI00342
database_cross_reference: CCPSS:1005810
database_cross_reference: CHV:0000005746
database_cross_reference: COSTAR:340
database_cross_reference: CSP:2587-5894
database_cross_reference: CST:GYNECOMASTIA
database_cross_reference: DO:DOID:12698
database_cross_reference: DXP:U001755
database_cross_reference: HPO:HP:0000771
database_cross_reference: ICD10CM:N62
database_cross_reference: ICPC2P:Y16005
database_cross_reference: ICPC2P:Y99011
database_cross_reference: MDR:10006244
database_cross_reference: MDR:10014844
database_cross_reference: MDR:10018800
database_cross_reference: MDR:10018801
database_cross_reference: MEDCIN:283172
database_cross_reference: MEDCIN:332421
database_cross_reference: MEDLINEPLUS:474
database_cross_reference: MSH:D006177
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:611.1
database_cross_reference: NCI:C3073
database_cross_reference: NCI_CTCAE:E13115
database_cross_reference: NCI_NICHD:C3073
database_cross_reference: NDFRT:N0000001396
database_cross_reference: OMIM:MTHU006965
database_cross_reference: RCD:XE0eN
database_cross_reference: RCDAE:XE0eN
database_cross_reference: SNM:M-71000
database_cross_reference: SNMI:D7-90420
database_cross_reference: SNOMEDCT_US:155963008
database_cross_reference: SNOMEDCT_US:198112004
database_cross_reference: SNOMEDCT_US:266646002
database_cross_reference: SNOMEDCT_US:4754008
database_cross_reference: SNOMEDCT_VET:311361000009109
database_cross_reference: SNOMEDCT_VET:4754008

Hypoplastic areola
type: Class
subclass of: Abnormal breast morphology
Definition: Underdevelopment of the areola, the circular area of pigmented skin surrounding the nipple.
MCID: MC01398822
PMOID: PMO:00004437
Subclass_of: Abnormal breast morphology
Synonym: Hypoplastic areolae
Tree Number: T3.8.1.6
database_cross_reference: HPO:HP:0100853

Abnormal breast physiology
type: Class
subclass of: Abnormality of the breast
Definition: Any anomaly of the function of the breast.
MCID: MC01395779
PMOID: PMO:00004438
Subclass_of: Abnormality of the breast
Tree Number: T3.8.2
database_cross_reference: HPO:HP:0031094

Agalactia
type: Class
subclass of: Abnormal breast physiology
Definition: Failure of secretion of milk following childbirth associated with an inability to breastfeed an infant.
MCID: MC00058360
PMOID: PMO:00004439
Subclass_of: Abnormal breast physiology
Synonym: Absence of lactation
Synonym: Agalactorrhea
Synonym: Agalactosis
Synonym: Failed lactation
Synonym: Failure of lactation
Synonym: Failure of lactation (disorder)
Synonym: Failure of lactation - delivered
Synonym: Failure of lactation - delivered (disorder)
Synonym: Failure of lactation NOS
Synonym: Failure of lactation NOS (disorder)
Tree Number: T3.8.2.1
database_cross_reference: CHV:0000017190
database_cross_reference: DO:DOID:1402
database_cross_reference: HPO:HP:0031109
database_cross_reference: ICD10:O92.3
database_cross_reference: ICD10AM:O92.3
database_cross_reference: ICD10CM:O92.3
database_cross_reference: ICD9CM:676.4
database_cross_reference: ICD9CM:676.40
database_cross_reference: ICPC2P:W19012
database_cross_reference: MDR:10016125
database_cross_reference: MDR:10016154
database_cross_reference: MDR:10016157
database_cross_reference: MEDCIN:34349
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:676.4
database_cross_reference: MTHICD9:676.40
database_cross_reference: NCI:C114409
database_cross_reference: NCI_NICHD:C114409
database_cross_reference: RCD:L464.
database_cross_reference: RCD:L4640
database_cross_reference: RCD:L464z
database_cross_reference: SNM:F-31925
database_cross_reference: SNMI:D8-41240
database_cross_reference: SNOMEDCT_US:156287009
database_cross_reference: SNOMEDCT_US:200432009
database_cross_reference: SNOMEDCT_US:200437003
database_cross_reference: SNOMEDCT_US:6995000
database_cross_reference: SNOMEDCT_VET:6995000

Galactorrhea
type: Class
subclass of: Abnormal breast physiology
Definition: Spontaneous flow of milk from the breast, unassociated with childbirth or nursing.
MCID: MC00080096
PMOID: PMO:00004440
Subclass_of: Abnormal breast physiology
Synonym: GALACTORRHEA
Synonym: GALACTORRHEA FEMALE
Synonym: GALACTORRHEA NONOBSTETRIC
Synonym: Galactorrhea - non-obstetric
Synonym: Galactorrhea due to non-obstetric cause
Synonym: Galactorrhea due to non-obstetric cause (disorder)
Synonym: Galactorrhea female
Synonym: Galactorrhea not associated with childbirth
Synonym: Galactorrhea not associated with childbirth (disorder)
Synonym: Galactorrhea, NOS
Tree Number: T3.8.2.2
database_cross_reference: CCPSS:0002686
database_cross_reference: CST:LACTATION FEM
database_cross_reference: DO:DOID:10689
database_cross_reference: ICD10:N64.3
database_cross_reference: ICD10AM:N64.3
database_cross_reference: ICD10AMAE:N64.3
database_cross_reference: ICD10CM:N64.3
database_cross_reference: ICD9CM:611.6
database_cross_reference: MDR:10017594
database_cross_reference: MDR:10017595
database_cross_reference: MDR:10017600
database_cross_reference: MDR:10017603
database_cross_reference: MDR:10023668
database_cross_reference: MDR:10023669
database_cross_reference: MDR:10073888
database_cross_reference: MEDCIN:35161
database_cross_reference: MSH:C537072
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU053309
database_cross_reference: RCD:K316.
database_cross_reference: RCD:XM0B1
database_cross_reference: RCDAE:K316.
database_cross_reference: RCDAE:XM0B1
database_cross_reference: SNM:F-31923
database_cross_reference: SNMI:D7-90444
database_cross_reference: SNOMEDCT_US:198115002
database_cross_reference: SNOMEDCT_US:78622004

Abnormality of the cardiovascular system
type: Class
subclass of: Phenotypic Abnormality
Definition: Any abnormality of the cardiovascular system.
MCID: MC00081865
PMOID: PMO:00004441
Subclass_of: Phenotypic Abnormality
Synonym: ABNORM CARDIOVASC
Synonym: Abnormalities, Cardiovascular
Synonym: Abnormality, Cardiovascular
Synonym: CARDIOVASC ABNORM
Synonym: CARDIOVASCULAR ABNORMALITY
Synonym: Cardiovascular Abnormalities
Synonym: Cardiovascular Abnormalities [Disease/Finding]
Synonym: Cardiovascular Abnormality
Synonym: Cardiovascular abnormality
Synonym: Cardiovascular system--Abnormalities
Tree Number: T3.9
database_cross_reference: CHV:0000025094
database_cross_reference: DXP:U000554
database_cross_reference: HPO:HP:0001626
database_cross_reference: LCH_NW:sh85020227
database_cross_reference: MSH:D018376
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003808

Abnormal cardiac test
type: Class
subclass of: Abnormality of the cardiovascular system
Definition: Abnormal test result of cardiovascular physiology.
MCID: MC01395792
PMOID: PMO:00004442
Subclass_of: Abnormality of the cardiovascular system
Tree Number: T3.9.1
database_cross_reference: HPO:HP:0500015

Abnormal cardiac biomarker test
type: Class
subclass of: Abnormal cardiac test
Definition: Abnormal blood test results measuring creatine kinase (CK), CK-MB, troponin (TROPI), myoglobin, and/or cardiac enzymes.
MCID: MC01395788
PMOID: PMO:00004443
Subclass_of: Abnormal cardiac test
Tree Number: T3.9.1.1
database_cross_reference: HPO:HP:0500020

Abnormal cardiac catheterization
type: Class
subclass of: Abnormal cardiac test
Definition: Abnormal results from the diagnostic tests resulting from cardiac catheterization.
MCID: MC01395789
PMOID: PMO:00004446
Subclass_of: Abnormal cardiac test
Synonym: Abnormal cardiac cath
Tree Number: T3.9.1.2
database_cross_reference: HPO:HP:0500017

Abnormal cardiac exercise stress test
type: Class
subclass of: Abnormal cardiac test
Definition: Abnormal results of exercise on heart function.
MCID: MC01395790
PMOID: PMO:00004447
Subclass_of: Abnormal cardiac test
Synonym: Abnormal cardiac exercise test
Synonym: Abnormal treadmill test
Tree Number: T3.9.1.3
database_cross_reference: HPO:HP:0500018

Abnormal cardiac MRI
type: Class
subclass of: Abnormal cardiac test
Definition: Abnormal results of a MRI for the heart.
MCID: MC01395791
PMOID: PMO:00004448
Subclass_of: Abnormal cardiac test
Synonym: Abnormal cardiac magnetic resonance imaging
Synonym: Abnormal heart MRI
Tree Number: T3.9.1.4
database_cross_reference: HPO:HP:0500016

Abnormal resting energy expenditure from metabolic cart test
type: Class
subclass of: Abnormal cardiac test
Definition: Resting energy expenditure (REE) can be measured with indirect calorimetry using a metabolic cart, which is used to measure the oxygen consumption (VO2) and carbon dioxide production (VCO2).
MCID: MC01396111
PMOID: PMO:00004449
Subclass_of: Abnormal cardiac test
Synonym: Abnormal metabolic cart test
Tree Number: T3.9.1.5
database_cross_reference: HPO:HP:0500019

Abnormality of cardiovascular system morphology
type: Class
subclass of: Abnormality of the cardiovascular system
Definition: Any structural anomaly of the heart and great vessels.
MCID: MC01012931
PMOID: PMO:00004450
Subclass_of: Abnormality of the cardiovascular system
Synonym: Cardiovascular malformations
Tree Number: T3.9.2
database_cross_reference: HPO:HP:0030680
database_cross_reference: MTH:NOCODE

Abnormal heart morphology
type: Class
subclass of: Abnormality of cardiovascular system morphology
Definition: Any structural anomaly of the heart.
MCID: MC00005978
PMOID: PMO:00004451
Subclass_of: Abnormality of cardiovascular system morphology
Synonym: 4-31 CONGENITAL ANOMALIES OF THE HEART
Synonym: ABNORM HEART
Synonym: ANOMALY CARDIAC
Synonym: ANOMALY HEART
Synonym: Abnormalities, Heart
Synonym: Abnormality of cardiac morphology
Synonym: Abnormality of the heart
Synonym: Abnormality, Heart
Synonym: Anomaly cardiac
Synonym: Anomaly heart
Tree Number: T3.9.2.1
database_cross_reference: AOD:0000005254
database_cross_reference: CCPSS:0043687
database_cross_reference: CHV:0000005874
database_cross_reference: COSTAR:U000203
database_cross_reference: CSP:0724-8315
database_cross_reference: CST:ANOMALY HEART
database_cross_reference: DO:DOID:1682
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000547
database_cross_reference: HPO:HP:0001627
database_cross_reference: HPO:HP:0002564
database_cross_reference: ICD10:Q24.9
database_cross_reference: ICD10AM:Q24.9
database_cross_reference: ICD10CM:Q24.9
database_cross_reference: ICD9CM:746.9
database_cross_reference: ICPC2P:K73004
database_cross_reference: LCH_NW:sh85059634
database_cross_reference: MDR:10002616
database_cross_reference: MDR:10002626
database_cross_reference: MDR:10019293
database_cross_reference: MDR:10025528
database_cross_reference: MDR:10045703
database_cross_reference: MEDCIN:33162
database_cross_reference: MEDLINEPLUS:198
database_cross_reference: MSH:D006330
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:746.9
database_cross_reference: NCI:C34666
database_cross_reference: NDFRT:N0000001431
database_cross_reference: OMIM:140500
database_cross_reference: OMIM:234750
database_cross_reference: OMIM:MTHU008662
database_cross_reference: OMIM:MTHU013668
database_cross_reference: OMIM:MTHU021246
database_cross_reference: OMIM:MTHU024793
database_cross_reference: OMIM:MTHU033032
database_cross_reference: OMIM:MTHU036327
database_cross_reference: RCD:P6zz.
database_cross_reference: SNMI:D4-31000
database_cross_reference: SNOMEDCT_US:13213009
database_cross_reference: SNOMEDCT_US:156911006
database_cross_reference: SNOMEDCT_US:156926008
database_cross_reference: SNOMEDCT_US:204405005
database_cross_reference: SNOMEDCT_US:204413006
database_cross_reference: SNOMEDCT_US:268315002
database_cross_reference: SNOMEDCT_US:268318000

Cardiovascular calcification
type: Class
subclass of: Abnormality of cardiovascular system morphology
Definition: Abnormal calcification in the cardiovascular system.
MCID: MC01001221
PMOID: PMO:00004706
Subclass_of: Abnormality of cardiovascular system morphology
Tree Number: T3.9.2.2
database_cross_reference: HPO:HP:0011915

Abnormality of cardiovascular system physiology
type: Class
subclass of: Abnormality of the cardiovascular system
Definition: Abnormal functionality of the cardiovascular system.
MCID: MC01001528
PMOID: PMO:00004713
Subclass_of: Abnormality of the cardiovascular system
Tree Number: T3.9.3
database_cross_reference: HPO:HP:0011025

Abnormal cardiac atrial physiology
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: An abnormality of the function of the cardiac atria.
MCID: MC01395787
PMOID: PMO:00004714
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.1
database_cross_reference: HPO:HP:0025443

Abnormal cardiac ventricular function
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: An abnormality of the cardiac ventricular function.
MCID: MC01395793
PMOID: PMO:00004717
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.2
database_cross_reference: HPO:HP:0030872

Abnormal echocardiogram
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: An abnormality detectable by sonography of the heart (echocardiography).
MCID: MC01395869
PMOID: PMO:00004729
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: Abnormal echocardiography
Tree Number: T3.9.3.3
database_cross_reference: HPO:HP:0003116

Abnormal heart sound
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: Any abnormal noise generated by the beating heart.
MCID: MC01395920
PMOID: PMO:00004731
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.4
database_cross_reference: HPO:HP:0031657

Abnormal heart valve physiology
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: Any functional abnormality of a cardiac valve.
MCID: MC01395921
PMOID: PMO:00004747
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.5
database_cross_reference: HPO:HP:0031653

Abnormal systemic blood pressure
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: A chronic deviation from normal pressure in the systemic arterial system.
MCID: MC01396164
PMOID: PMO:00004764
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.6
database_cross_reference: HPO:HP:0030972

Abnormal vascular physiology
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: Abnormality of vascular function.
MCID: MC01000955
PMOID: PMO:00004782
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.7
database_cross_reference: HPO:HP:0030163

Abnormality of blood circulation
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: An abnormality of blood circulation.
PMOID: PMO:00004807
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.8

Abnormality of cardiovascular system electrophysiology
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: An anomaly of the electrical conduction physiology of the heart.
MCID: MC01396250
PMOID: PMO:00004822
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.9
database_cross_reference: HPO:HP:0030956

Angina pectoris
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: Paroxysmal chest pain that occurs with exertion or stress and is related to myocardial ischemia.
MCID: MC00000916
PMOID: PMO:00004943
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: 3-12 ANGINAL SYNDROMES
Synonym: ANGINA
Synonym: ANGINA PECTORIS
Synonym: ANGINAL PAIN
Synonym: ANGINAL SYNDROME
Synonym: ANGINAL SYNDROMES
Synonym: AP - Angina pectoris
Synonym: Angina
Synonym: Angina (disorder)
Synonym: Angina NOS
Tree Number: T3.9.3.10
database_cross_reference: AOD:0000005328
database_cross_reference: AOD:0000005330
database_cross_reference: AOD:0000023333
database_cross_reference: BI:BI00018
database_cross_reference: BI:BI00047
database_cross_reference: CCPSS:1017852
database_cross_reference: CHV:0000001165
database_cross_reference: COSTAR:053
database_cross_reference: COSTAR:054
database_cross_reference: CSP:1393-3407
database_cross_reference: CST:ANGINA PECTORIS
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000113
database_cross_reference: DXP:U000178
database_cross_reference: HPO:HP:0001681
database_cross_reference: ICD10:I20
database_cross_reference: ICD10:I20.9
database_cross_reference: ICD10AM:I20
database_cross_reference: ICD10AM:I20.9
database_cross_reference: ICD10CM:I20
database_cross_reference: ICD10CM:I20.8
database_cross_reference: ICD10CM:I20.9
database_cross_reference: ICD9CM:413
database_cross_reference: ICPC2EENG:K74
database_cross_reference: ICPC2P:K74001
database_cross_reference: ICPC2P:K74002
database_cross_reference: LCH:U000244
database_cross_reference: LCH_NW:sh85005022
database_cross_reference: LNC:LA14275-4
database_cross_reference: MDR:10002372
database_cross_reference: MDR:10002383
database_cross_reference: MDR:10002387
database_cross_reference: MDR:10002391
database_cross_reference: MDR:10002393
database_cross_reference: MDR:10041972
database_cross_reference: MDR:10054224
database_cross_reference: MDR:10056256
database_cross_reference: MDR:10056259
database_cross_reference: MEDCIN:33215
database_cross_reference: MEDCIN:354217
database_cross_reference: MEDLINEPLUS:142
database_cross_reference: MSH:D000787
database_cross_reference: MTH:053
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:413.9
database_cross_reference: NCI:C51221
database_cross_reference: NCI_CTCAE:E10110
database_cross_reference: NCI_FDA:1710
database_cross_reference: NCI_NICHD:C51221
database_cross_reference: NDFRT:N0000000406
database_cross_reference: OMIM:MTHU008097
database_cross_reference: OMIM:MTHU009903
database_cross_reference: PSY:02530
database_cross_reference: RCD:G33..
database_cross_reference: RCD:G33z.
database_cross_reference: RCD:G33z1
database_cross_reference: RCD:Ua1eH
database_cross_reference: RCDAE:G33..
database_cross_reference: RCDAE:Ua1eH
database_cross_reference: SNM:D-7253
database_cross_reference: SNM:F-71500
database_cross_reference: SNMI:D3-12000
database_cross_reference: SNOMEDCT_US:155307004

Congestive heart failure
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.
MCID: MC00005980
PMOID: PMO:00004944
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: 3-16 HEART FAILURE AND OTHER FUNCTIONAL DISORDERS
Synonym: CARDIAC FAILURE
Synonym: CARDIAC INSUFFICIENCY
Synonym: CHF
Synonym: Cardiac Failure
Synonym: Cardiac Failure Congestive
Synonym: Cardiac Insufficiency
Synonym: Cardiac failure
Synonym: Cardiac failure (NOS)
Synonym: Cardiac failure NOS
Tree Number: T3.9.3.11
database_cross_reference: AOD:0000005305
database_cross_reference: AOD:0000005308
database_cross_reference: BI:BI00019
database_cross_reference: CCPSS:0017571
database_cross_reference: CHV:0000005877
database_cross_reference: CHV:0000050019
database_cross_reference: COSTAR:U000338
database_cross_reference: CSP:1393-3587
database_cross_reference: CST:HEART FAIL
database_cross_reference: DO:DOID:6000
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0001635
database_cross_reference: ICD10:I50
database_cross_reference: ICD10:I50.9
database_cross_reference: ICD10AM:I50
database_cross_reference: ICD10AM:I50.9
database_cross_reference: ICD10CM:I50
database_cross_reference: ICD10CM:I50.9
database_cross_reference: ICD9CM:428
database_cross_reference: ICD9CM:428.9
database_cross_reference: ICPC2EENG:K77
database_cross_reference: ICPC2P:K29019
database_cross_reference: ICPC2P:K77004
database_cross_reference: ICPC2P:K77011
database_cross_reference: ICPC2P:K77028
database_cross_reference: LCH:U005616
database_cross_reference: LCH_NW:sh85059745
database_cross_reference: MDR:10007554
database_cross_reference: MDR:10007555
database_cross_reference: MDR:10007562
database_cross_reference: MDR:10007568
database_cross_reference: MDR:10007569
database_cross_reference: MDR:10007582
database_cross_reference: MDR:10016145
database_cross_reference: MDR:10019279
database_cross_reference: MDR:10019280
database_cross_reference: MDR:10019282
database_cross_reference: MDR:10019285
database_cross_reference: MDR:10019290
database_cross_reference: MDR:10022462
database_cross_reference: MEDCIN:95724
database_cross_reference: MEDLINEPLUS:199
database_cross_reference: MSH:D006333
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:428.9
database_cross_reference: NCI:C50577
database_cross_reference: NCI_CTCAE:E10124
database_cross_reference: NCI_FDA:2206
database_cross_reference: NCI_NICHD:C50577
database_cross_reference: OMIM:MTHU009472
database_cross_reference: OMIM:MTHU012782
database_cross_reference: OMIM:MTHU052864
database_cross_reference: RCD:G58..
database_cross_reference: RCD:XE0V9
database_cross_reference: SNM:D-7050
database_cross_reference: SNMI:D3-16000
database_cross_reference: SNOMEDCT_US:155374007
database_cross_reference: SNOMEDCT_US:155375008
database_cross_reference: SNOMEDCT_US:155377000
database_cross_reference: SNOMEDCT_US:195117009
database_cross_reference: SNOMEDCT_US:266248006
database_cross_reference: SNOMEDCT_US:266308000
database_cross_reference: SNOMEDCT_US:84114007

Myocardial infarction
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin.
MCID: MC00008560
PMOID: PMO:00004951
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: -- Heart Attack
Synonym: AMI
Synonym: ATTACK CORONARY
Synonym: ATTACK HEART (NOS)
Synonym: Ami
Synonym: Attack - heart
Synonym: Attack coronary
Synonym: Attack heart (NOS)
Synonym: Cardiac infarct
Synonym: Cardiac infarction
Tree Number: T3.9.3.12
database_cross_reference: AOD:0000005332
database_cross_reference: AOD:0000023334
database_cross_reference: AOD:0000023335
database_cross_reference: BI:BI00102
database_cross_reference: CCPSS:1018028
database_cross_reference: CHV:0000008423
database_cross_reference: COSTAR:505
database_cross_reference: CSP:1393-3417
database_cross_reference: CST:CORONARY ART DIS
database_cross_reference: CST:INFARCT MYOCARD
database_cross_reference: DO:DOID:5844
database_cross_reference: DRUGBANK:DB00548
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0001658
database_cross_reference: ICD10CM:I21
database_cross_reference: ICD10CM:I22
database_cross_reference: ICPC2P:K75001
database_cross_reference: ICPC2P:K75013
database_cross_reference: ICPC2P:K75014
database_cross_reference: LCH_NW:sh85059683
database_cross_reference: LNC:LA10558-7
database_cross_reference: LNC:LA14274-7
database_cross_reference: LNC:LP98884-7
database_cross_reference: LNC:MTHU035551
database_cross_reference: MDR:10003723
database_cross_reference: MDR:10003724
database_cross_reference: MDR:10019250
database_cross_reference: MDR:10021758
database_cross_reference: MDR:10027524
database_cross_reference: MDR:10028595
database_cross_reference: MDR:10028596
database_cross_reference: MEDCIN:353001
database_cross_reference: MEDLINEPLUS:5
database_cross_reference: MSH:D009203
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:410.9
database_cross_reference: NCI:C27996
database_cross_reference: NCI_CTCAE:E10152
database_cross_reference: NCI_FDA:1969
database_cross_reference: NCI_NICHD:C27996
database_cross_reference: NDFRT:N0000002085
database_cross_reference: OMIM:MTHU002361
database_cross_reference: OMIM:MTHU008101
database_cross_reference: PSY:22465
database_cross_reference: PSY:25140
database_cross_reference: PSY:32820
database_cross_reference: RCD:X200E
database_cross_reference: SNM:D-7256
database_cross_reference: SNM:M-54700
database_cross_reference: SNMI:D3-15000
database_cross_reference: SNOMEDCT_US:155304006
database_cross_reference: SNOMEDCT_US:194796000
database_cross_reference: SNOMEDCT_US:22298006
database_cross_reference: SNOMEDCT_US:233824008
database_cross_reference: SNOMEDCT_US:266288001
database_cross_reference: SNOMEDCT_US:66514008
database_cross_reference: SNOMEDCT_VET:22298006

Presyncope
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: Presyncope is a state of lightheadedness, muscular weakness, blurred vision, and feeling faint. Presyncope is most often cardiovascular in cause.
MCID: MC00231818
PMOID: PMO:00004952
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: NEAR SYNCOPE
Synonym: Near syncope
Synonym: Near syncope (disorder)
Synonym: PRESYNCOPE
Synonym: Pre-syncope
Synonym: Presyncopes
Synonym: near syncope
Synonym: pre syncope
Synonym: pre-syncope
Synonym: presyncope
Tree Number: T3.9.3.13
database_cross_reference: BI:BI00557
database_cross_reference: CCPSS:1004860
database_cross_reference: CHV:0000044688
database_cross_reference: COSTAR:U000441
database_cross_reference: CST:DIZZINESS
database_cross_reference: HPO:HP:0031972
database_cross_reference: MDR:10036507
database_cross_reference: MDR:10036653
database_cross_reference: MDR:10066203
database_cross_reference: MSH:D013575
database_cross_reference: NCI:C80100
database_cross_reference: NCI_CTCAE:E12778
database_cross_reference: NCI_NICHD:C80100
database_cross_reference: SNOMEDCT_US:427461000

Shock
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury.
MCID: MC00011821
PMOID: PMO:00004953
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: Acute circulatory failure
Synonym: Acute peripheral circulatory failure
Synonym: CARDIOVASCULAR COLLAPSE
Synonym: CIRCULATORY COLLAPSE
Synonym: CIRCULATORY FAILURE
Synonym: CIRCULATORY FAILURE ACUTE
Synonym: COLLAPSE CARDIOVASCULAR
Synonym: COLLAPSE CIRCULATORY
Synonym: COLLAPSE PERIPHERAL CIRCULATORY
Synonym: COLLAPSE PERIPHERAL VASCULAR
Tree Number: T3.9.3.14
database_cross_reference: CCPSS:0034105
database_cross_reference: CCPSS:0037429
database_cross_reference: CHV:0000011301
database_cross_reference: CHV:0000039014
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1583-6527
database_cross_reference: CST:CVSHOCK
database_cross_reference: CST:SHOCK
database_cross_reference: DXP:U003549
database_cross_reference: HPO:HP:0031273
database_cross_reference: ICD10:R57.9
database_cross_reference: ICD10AM:R57.9
database_cross_reference: ICD10CM:R57.9
database_cross_reference: ICD9CM:785.50
database_cross_reference: LCH:U004299
database_cross_reference: LCH_NW:sh85121705
database_cross_reference: LNC:LA7473-7
database_cross_reference: MDR:10000692
database_cross_reference: MDR:10007647
database_cross_reference: MDR:10009192
database_cross_reference: MDR:10009195
database_cross_reference: MDR:10009908
database_cross_reference: MDR:10009909
database_cross_reference: MDR:10009910
database_cross_reference: MDR:10009914
database_cross_reference: MDR:10009915
database_cross_reference: MDR:10009917
database_cross_reference: MDR:10016144
database_cross_reference: MDR:10016161
database_cross_reference: MDR:10034567
database_cross_reference: MDR:10040560
database_cross_reference: MDR:10040564
database_cross_reference: MDR:10040583
database_cross_reference: MDR:10040585
database_cross_reference: MDR:10047052
database_cross_reference: MEDCIN:33395
database_cross_reference: MEDLINEPLUS:5717
database_cross_reference: MSH:D012769
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:785.50
database_cross_reference: NCI:C35016
database_cross_reference: NCI_FDA:2072
database_cross_reference: NCI_NICHD:C35016
database_cross_reference: NDFRT:N0000002728
database_cross_reference: OMIM:MTHU032133
database_cross_reference: PSY:47200
database_cross_reference: RCD:R0550
database_cross_reference: RCD:XM00r
database_cross_reference: RCD:XM1C7
database_cross_reference: RCDSY:R0550
database_cross_reference: SNM:F-70010
database_cross_reference: SNMI:D3-80600
database_cross_reference: SNOMEDCT_US:158354004
database_cross_reference: SNOMEDCT_US:207026006
database_cross_reference: SNOMEDCT_US:267302008
database_cross_reference: SNOMEDCT_US:274729009
database_cross_reference: SNOMEDCT_US:27942005
database_cross_reference: SNOMEDCT_VET:27942005

Syncope
type: Class
subclass of: Abnormality of cardiovascular system physiology
Definition: Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow.
MCID: MC00012485
PMOID: PMO:00004958
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: A faint
Synonym: Attack(s);fainting
Synonym: COLLAPSE FLEETING
Synonym: COLLAPSE TRANSIENT
Synonym: Collapse [D]
Synonym: Collapse fleeting
Synonym: Collapse transient
Synonym: FAINT
Synonym: FAINTING
Synonym: FAINTING EPISODES
Tree Number: T3.9.3.15
database_cross_reference: AOD:0000004427
database_cross_reference: AOD:0000022991
database_cross_reference: BI:BI00562
database_cross_reference: CCPSS:1004859
database_cross_reference: CCPSS:1018236
database_cross_reference: CHV:0000011975
database_cross_reference: CHV:0000037419
database_cross_reference: COSTAR:716
database_cross_reference: COSTAR:U000277
database_cross_reference: CSP:2056-8027
database_cross_reference: CST:DIZZINESS
database_cross_reference: CST:SYNCOPE
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U003903
database_cross_reference: HPO:HP:0001279
database_cross_reference: ICD10:R55
database_cross_reference: ICD10AM:R55
database_cross_reference: ICD10CM:R55
database_cross_reference: ICD9CM:780.2
database_cross_reference: ICPC2EENG:A06
database_cross_reference: ICPC2P:A06003
database_cross_reference: ICPC2P:A06005
database_cross_reference: ICPC2P:A06009
database_cross_reference: ICPC2P:A06012
database_cross_reference: LNC:LA16987-2
database_cross_reference: LNC:MTHU020851
database_cross_reference: MDR:10009911
database_cross_reference: MDR:10009916
database_cross_reference: MDR:10016167
database_cross_reference: MDR:10016169
database_cross_reference: MDR:10016170
database_cross_reference: MDR:10016179
database_cross_reference: MDR:10034100
database_cross_reference: MDR:10042729
database_cross_reference: MDR:10042771
database_cross_reference: MDR:10042772
database_cross_reference: MDR:10042773
database_cross_reference: MEDCIN:663
database_cross_reference: MEDLINEPLUS:1481
database_cross_reference: MSH:D013575
database_cross_reference: MTH:U003368
database_cross_reference: MTHICD9:780.2
database_cross_reference: NCI:C35053
database_cross_reference: NCI:C50857
database_cross_reference: NCI_CTCAE:E12832
database_cross_reference: NCI_FDA:1610
database_cross_reference: NCI_FDA:1847
database_cross_reference: NCI_NICHD:C35053
database_cross_reference: NDFRT:N0000002873
database_cross_reference: OMIM:MTHU005009
database_cross_reference: OMIM:MTHU046179
database_cross_reference: PSY:19110
database_cross_reference: PSY:51160
database_cross_reference: RCD:R002.
database_cross_reference: RCD:R0021
database_cross_reference: RCD:R002z
database_cross_reference: RCD:XM010
database_cross_reference: RCD:XM06a
database_cross_reference: RCD:XM0CY
database_cross_reference: RCD:XaBua
database_cross_reference: RCDSY:R002.
database_cross_reference: RCDSY:R0021
database_cross_reference: RCDSY:R002z

Abnormality of the fetal cardiovascular system
type: Class
subclass of: Abnormality of the cardiovascular system
Definition: An abnormality of the fetal circulation system or fetal echocardiogram.
MCID: MC00999908
PMOID: PMO:00004962
Subclass_of: Abnormality of the cardiovascular system
Synonym: Abnormality of the fetal circulation system
Tree Number: T3.9.4
database_cross_reference: HPO:HP:0010948

Abnormality of ductus venosus blood flow
type: Class
subclass of: Abnormality of the fetal cardiovascular system
Definition: An first-trimester prenatal ultrasound finding of abnormal blood flow in the ductus venosus.
MCID: MC01396279
PMOID: PMO:00004963
Subclass_of: Abnormality of the fetal cardiovascular system
Tree Number: T3.9.4.1
database_cross_reference: HPO:HP:0010947

Abnormality of umbilical vein blood flow
type: Class
subclass of: Abnormality of the fetal cardiovascular system
Definition: An first-trimester prenatal ultrasound finding of abnormal blood flow in the umbilical vein.
MCID: MC01396417
PMOID: PMO:00004964
Subclass_of: Abnormality of the fetal cardiovascular system
Tree Number: T3.9.4.2
database_cross_reference: HPO:HP:0010949

Congenital portosystemic venous shunt
type: Class
subclass of: Abnormality of the fetal cardiovascular system
Definition: A congenital defect of the vasculature such that there is a shunt (by-pass) of blood directly from the portal vein to the vena cava (i.e., the blood from the portal vein is not filtered through the liver).
MCID: MC00121800
PMOID: PMO:00004965
Subclass_of: Abnormality of the fetal cardiovascular system
Synonym: PATENT DUCTUS VENOSUS
Synonym: PDV
Synonym: PORTOSYSTEMIC VENOUS SHUNT, CONGENITAL
Synonym: PSVS
Synonym: Patent Ductus Venosus
Synonym: Patent ductus venosus
Synonym: Patent ductus venosus (disorder)
Synonym: Portosystemic Venous Shunt, Congenital
Synonym: patent ductus venosus
Tree Number: T3.9.4.3
database_cross_reference: CHV:0000030979
database_cross_reference: HPO:HP:0012022
database_cross_reference: MSH:C562830
database_cross_reference: OMIM:601466
database_cross_reference: RCD:X77uw
database_cross_reference: SNOMEDCT_US:253330006

Echogenic intracardiac focus
type: Class
subclass of: Abnormality of the fetal cardiovascular system
Definition: A finding of a focus of increased echogenicity upon prenatal ultrasound examination of the fetus. The foci may be present in one or both ventricles. Echogenic intracardiac focus (EICF) is defined as a focus of echogenicity comparable to bone, in the region of the papillary muscle in either or both ventricles of the fetal heart.
MCID: MC01397947
PMOID: PMO:00004966
Subclass_of: Abnormality of the fetal cardiovascular system
Tree Number: T3.9.4.4
database_cross_reference: HPO:HP:0010942

Persistent fetal circulation
type: Class
subclass of: Abnormality of the fetal cardiovascular system
Definition: Systemic desaturation of a liveborn baby resulting from persistent pulmonary hypertension with a patent ductus arteriosus and patent foramen ovale, such that the circulation in postnatal life follows the fetal course.
MCID: MC00009954
PMOID: PMO:00004967
Subclass_of: Abnormality of the fetal cardiovascular system
Synonym: (Persistent) pulmonary hypertension of newborn
Synonym: ACD MPV
Synonym: ACD-MPV
Synonym: ACDMPV
Synonym: ALVEOLAR CAPILLARY DYSPLASIA WITH MISALIGNMENT OF PULMONARY VEINS
Synonym: ALVEOLAR CAPILLARY DYSPLASIA WITH MISALIGNMENT OF PULMONARY VEINS AND OTHER CONGENITAL ANOMALIES
Synonym: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Synonym: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins And Other Congenital Anomalies
Synonym: CIRC PERSISTENT FETAL
Synonym: Circulation, Persistent Fetal
Tree Number: T3.9.4.5
database_cross_reference: CSP:0723-5955
database_cross_reference: CSP:2595-6954
database_cross_reference: DO:DOID:13042
database_cross_reference: DXP:U000645
database_cross_reference: DXP:U001469
database_cross_reference: HPO:HP:0011726
database_cross_reference: ICD10:P29.3
database_cross_reference: ICD10AM:P29.3
database_cross_reference: ICD10CM:P29.3
database_cross_reference: ICD9CM:747.83
database_cross_reference: ICPC2P:A94023
database_cross_reference: LCH_NW:sh90000431
database_cross_reference: MDR:10034708
database_cross_reference: MDR:10034709
database_cross_reference: MDR:10053592
database_cross_reference: MDR:10054726
database_cross_reference: MEDCIN:272370
database_cross_reference: MEDCIN:35814
database_cross_reference: MSH:D010547
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85006
database_cross_reference: NCI_NICHD:C85006
database_cross_reference: NDFRT:N0000002380
database_cross_reference: OMIM:265380
database_cross_reference: OMIM:601089
database_cross_reference: OMIM:MTHU046520
database_cross_reference: RCD:Q493.
database_cross_reference: RCD:X2001
database_cross_reference: SNM:D-7003
database_cross_reference: SNMI:D4-30010
database_cross_reference: SNOMEDCT_US:204507004
database_cross_reference: SNOMEDCT_US:206597007
database_cross_reference: SNOMEDCT_US:233815004
database_cross_reference: SNOMEDCT_US:35604006

Persistent patent ductus venosus
type: Class
subclass of: Abnormality of the fetal cardiovascular system
Definition: Persistence of blood flow through the ductus venosus for longer than the normal time after birth.
MCID: MC01400381
PMOID: PMO:00004968
Subclass_of: Abnormality of the fetal cardiovascular system
Tree Number: T3.9.4.6
database_cross_reference: HPO:HP:0012021

Single umbilical artery
type: Class
subclass of: Abnormality of the fetal cardiovascular system
Definition: Single umbilical artery (SUA) is the absence of one of the two umbilical arteries surrounding the fetal bladder and in the fetal umbilical cord.
MCID: MC00474752
PMOID: PMO:00004969
Subclass_of: Abnormality of the fetal cardiovascular system
Synonym: Congenital absence of umbilical artery
Synonym: Single Umbilical Arteries
Synonym: Single Umbilical Artery
Synonym: Single Umbilical Artery [Disease/Finding]
Synonym: Single artery AND vein of umbilical cord
Synonym: Single umbilical artery (disorder)
Synonym: Single umbilical artery -RETIRED-
Synonym: Two Vessel Cord
Synonym: Two Vessel Cords
Synonym: Two vessel cord
Tree Number: T3.9.4.7
database_cross_reference: CHV:0000026096
database_cross_reference: HPO:HP:0001195
database_cross_reference: ICD10CM:Q27.0
database_cross_reference: MDR:10049807
database_cross_reference: MEDCIN:297999
database_cross_reference: MEDCIN:355333
database_cross_reference: MSH:D058529
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:747.5
database_cross_reference: NCI:C117359
database_cross_reference: NCI_NICHD:C117359
database_cross_reference: NDFRT:N0000182214
database_cross_reference: OMIM:MTHU037190
database_cross_reference: OMIM:MTHU037229
database_cross_reference: OMIM:MTHU039171
database_cross_reference: RCD:P752.
database_cross_reference: SNMI:D4-F5045
database_cross_reference: SNOMEDCT_US:123277001
database_cross_reference: SNOMEDCT_US:204470001
database_cross_reference: SNOMEDCT_US:63070006

Abnormality of the vasculature
type: Class
subclass of: Abnormality of the cardiovascular system
Definition: An abnormality of the vasculature.
MCID: MC01396408
PMOID: PMO:00004970
Subclass_of: Abnormality of the cardiovascular system
Synonym: Abnormality of blood vessels
Synonym: Vascular abnormalities
Tree Number: T3.9.5
database_cross_reference: HPO:HP:0002597

Abnormal vascular morphology
type: Class
subclass of: Abnormality of the vasculature
MCID: MC01062180
PMOID: PMO:00004971
Subclass_of: Abnormality of the vasculature
Tree Number: T3.9.5.1
database_cross_reference: HPO:HP:0025015

Abnormality of the pulmonary vasculature
type: Class
subclass of: Abnormality of the vasculature
MCID: MC01002719
PMOID: PMO:00005276
Subclass_of: Abnormality of the vasculature
Synonym: Abnormality of the lung blood vessels
Tree Number: T3.9.5.2
database_cross_reference: HPO:HP:0004930

Abnormality of the digestive system
type: Class
subclass of: Phenotypic Abnormality
MCID: MC00090730
PMOID: PMO:00005299
Subclass_of: Phenotypic Abnormality
Synonym: 4-50 CONGENITAL ANOMALIES OF THE DIGESTIVE SYSTEM: GENERAL TERMS
Synonym: ABNORM DIGESTIVE SYSTEM
Synonym: Abnormalities, Digestive System
Synonym: Abnormality, Digestive System
Synonym: Anom digestive syst NOS
Synonym: CONGENITAL ANOMALIES OF THE DIGESTIVE SYSTEM
Synonym: CONGENITAL ANOMALIES OF THE DIGESTIVE SYSTEM: GENERAL TERMS
Synonym: Congen malform digestive syst
Synonym: Congenital anomaly NOS of digestive system NOS
Synonym: Congenital anomaly digestive system
Tree Number: T3.10
database_cross_reference: CHV:0000003938
database_cross_reference: CHV:0000025980
database_cross_reference: HPO:HP:0025031
database_cross_reference: ICD10:Q45.9
database_cross_reference: ICD10AM:Q45.9
database_cross_reference: ICD10CM:Q45.9
database_cross_reference: ICD9CM:751.9
database_cross_reference: ICPC2EENG:D81
database_cross_reference: ICPC2P:D81006
database_cross_reference: MDR:10045697
database_cross_reference: MEDCIN:211250
database_cross_reference: MSH:D004065
database_cross_reference: MTH:U000145
database_cross_reference: MTHICD9:751.9
database_cross_reference: NDFRT:N0000000972
database_cross_reference: RCD:PBz..
database_cross_reference: RCD:Xa9Cy
database_cross_reference: SNMI:D4-50000
database_cross_reference: SNOMEDCT_US:204820005
database_cross_reference: SNOMEDCT_US:69518005

Abnormality of abdomen morphology
type: Class
subclass of: Abnormality of the digestive system
Definition: A structural abnormality of the abdomen ('belly'), that is, the part of the body between the pelvis and the thorax.
PMOID: PMO:00005300
Subclass_of: Abnormality of the digestive system
Tree Number: T3.10.1

Abdominal aseptic abscess
type: Class
subclass of: Abnormality of abdomen morphology
Definition: An abscess-like lesion located within the abdomen. The lesions are localized in the spleen, liver, abdominal lymph nodes. The lesions represent visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids, but relapses occur frequently.
MCID: MC01395730
PMOID: PMO:00005301
Subclass_of: Abnormality of abdomen morphology
Tree Number: T3.10.1.1
database_cross_reference: HPO:HP:0025181

Abdominal mass
type: Class
subclass of: Abnormality of abdomen morphology
Definition: An abnormal enlargement or swelling in the abdomen.
MCID: MC01395731
PMOID: PMO:00005302
Subclass_of: Abnormality of abdomen morphology
Tree Number: T3.10.1.2
database_cross_reference: HPO:HP:0031500

Ascites
type: Class
subclass of: Abnormality of abdomen morphology
Definition: Accumulation of fluid in the peritoneal cavity.
MCID: MC01396958
PMOID: PMO:00005303
Subclass_of: Abnormality of abdomen morphology
Synonym: Accumulation of fluid in the abdomen
Tree Number: T3.10.1.3
database_cross_reference: HPO:HP:0001541

Duplication of internal organs
type: Class
subclass of: Abnormality of abdomen morphology
MCID: MC01002691
PMOID: PMO:00005307
Subclass_of: Abnormality of abdomen morphology
Tree Number: T3.10.1.4
database_cross_reference: HPO:HP:0005217

Pelvic mass
type: Class
subclass of: Abnormality of abdomen morphology
Definition: An abnormal enlargement or swelling in the pelvic region.
MCID: MC01400311
PMOID: PMO:00005308
Subclass_of: Abnormality of abdomen morphology
Tree Number: T3.10.1.5
database_cross_reference: HPO:HP:0031501

Pelvic organ prolapse
type: Class
subclass of: Abnormality of abdomen morphology
Definition: Weakness in the supporting structures of the pelvic floor allowing the pelvic viscera to descend or one or more of the pelvic organs drop from their normal position.
MCID: MC00306881
PMOID: PMO:00005309
Subclass_of: Abnormality of abdomen morphology
Synonym: Organ Prolapse, Pelvic
Synonym: Organ Prolapses, Pelvic
Synonym: Pelvic Organ Prolapse
Synonym: Pelvic Organ Prolapse [Disease/Finding]
Synonym: Pelvic Organ Prolapses
Synonym: Prolapse, Pelvic Organ
Synonym: Prolapse, Urogenital
Synonym: Prolapses, Pelvic Organ
Synonym: Prolapses, Urogenital
Synonym: Urogenital Prolapse
Tree Number: T3.10.1.6
database_cross_reference: HPO:HP:0031607
database_cross_reference: MDR:10048670
database_cross_reference: MSH:D056887
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000181182

Visceromegaly
type: Class
subclass of: Abnormality of abdomen morphology
Definition: Abnormal increased size of the viscera of the abdomen.
MCID: MC00013609
PMOID: PMO:00005310
Subclass_of: Abnormality of abdomen morphology
Synonym: Visceromegaly (morphologic abnormality)
Tree Number: T3.10.1.7
database_cross_reference: HPO:HP:0003271
database_cross_reference: OMIM:MTHU032587
database_cross_reference: SNM:M-71000
database_cross_reference: SNMI:M-710B0
database_cross_reference: SNOMEDCT_US:28543008

Abnormality of digestive system morphology
type: Class
subclass of: Abnormality of the digestive system
Definition: A structural anomaly of the digestive system.
MCID: MC01062173
PMOID: PMO:00005313
Subclass_of: Abnormality of the digestive system
Tree Number: T3.10.2
database_cross_reference: HPO:HP:0025033

Abnormal stool composition
type: Class
subclass of: Abnormality of digestive system morphology
MCID: MC01396152
PMOID: PMO:00005314
Subclass_of: Abnormality of digestive system morphology
Synonym: Abnormal faeces composition
Synonym: Abnormal feces composition
Tree Number: T3.10.2.1
database_cross_reference: HPO:HP:0031685

Abnormality of digestive system physiology
type: Class
subclass of: Abnormality of the digestive system
Definition: A functional anomaly of the digestive system.
MCID: MC01062174
PMOID: PMO:00005318
Subclass_of: Abnormality of the digestive system
Tree Number: T3.10.3
database_cross_reference: HPO:HP:0025032

Abdominal symptom
type: Class
subclass of: Abnormality of digestive system physiology
MCID: MC00254045
PMOID: PMO:00005319
Subclass_of: Abnormality of digestive system physiology
Synonym: ABDOMEN SYMPTOM
Synonym: Abdominal symptom NOS
Synonym: abdominal symptom
Synonym: abdominal symptoms
Tree Number: T3.10.3.1
database_cross_reference: CCPSS:0034346
database_cross_reference: CHV:0000047152
database_cross_reference: HPO:HP:0011458
database_cross_reference: MDR:10000095
database_cross_reference: MDR:10060926

Abnormal large intestine physiology
type: Class
subclass of: Abnormality of digestive system physiology
Definition: A functional anomaly of the large intestine.
MCID: MC01001041
PMOID: PMO:00005357
Subclass_of: Abnormality of digestive system physiology
Tree Number: T3.10.3.2
database_cross_reference: HPO:HP:0012700

Abnormality of hepatobiliary system physiology
type: Class
subclass of: Abnormality of digestive system physiology
Definition: A fiunctional anomaly of the hepatobiliary system
MCID: MC01396307
PMOID: PMO:00005361
Subclass_of: Abnormality of digestive system physiology
Tree Number: T3.10.3.3
database_cross_reference: HPO:HP:0025155

Dependency on intravenous nutrition
type: Class
subclass of: Abnormality of digestive system physiology
Definition: Inability to be weaned from intravenous (parenteral) nutrition, as judged by the hydration status (urine output, blood urea nitrogen, creatinine, urine sodium concentration), ability to maintain weight, stool output, and serum electrolyte status.
MCID: MC01397778
PMOID: PMO:00005370
Subclass_of: Abnormality of digestive system physiology
Tree Number: T3.10.3.4
database_cross_reference: HPO:HP:0025156

Abnormality of the abdominal organs
type: Class
subclass of: Abnormality of the digestive system
Definition: An abnormality of the viscera of the abdomen.
MCID: MC01000318
PMOID: PMO:00005371
Subclass_of: Abnormality of the digestive system
Synonym: Gastrointestinal tract defects
Tree Number: T3.10.4
database_cross_reference: HPO:HP:0002012

Abnormality of mesentery morphology
type: Class
subclass of: Abnormality of the abdominal organs
Definition: Folds of membranous tissue (peritoneum, mesothelium) attached to the wall of the abdomen and enclosing viscera. Examples include the mesentery for the small intestine; the transverse mesocolon, which attaches the transverse portion of the colon to the back wall of the abdomen; and the mesosigmoid, which enfolds the sigmoid portion of the colon. Cells of the same embryologic origin also surround the other organs of the body such as the lungs (pleura) or the heart (pericardium).
MCID: MC01062162
PMOID: PMO:00005372
Subclass_of: Abnormality of the abdominal organs
Tree Number: T3.10.4.1
database_cross_reference: HPO:HP:0100016

Abnormality of the liver
type: Class
subclass of: Abnormality of the abdominal organs
Definition: An abnormality of the liver.
MCID: MC01000331
PMOID: PMO:00005375
Subclass_of: Abnormality of the abdominal organs
Synonym: Liver abnormality
Tree Number: T3.10.4.2
database_cross_reference: HPO:HP:0001392

Abnormality of the pancreas
type: Class
subclass of: Abnormality of the abdominal organs
Definition: An abnormality of the pancreas.
MCID: MC01003027
PMOID: PMO:00005503
Subclass_of: Abnormality of the abdominal organs
Tree Number: T3.10.4.3
database_cross_reference: HPO:HP:0001732

Abnormality of the peritoneum
type: Class
subclass of: Abnormality of the abdominal organs
Definition: An abnormality of the peritoneum.
MCID: MC01002981
PMOID: PMO:00005533
Subclass_of: Abnormality of the abdominal organs
Tree Number: T3.10.4.4
database_cross_reference: HPO:HP:0002585

Abnormality of the abdominal wall
type: Class
subclass of: Abnormality of the digestive system
Definition: The presence of any abnormality affecting the abdominal wall.
MCID: MC01000252
PMOID: PMO:00005541
Subclass_of: Abnormality of the digestive system
Synonym: Abnormality of external features of the abdomen
Tree Number: T3.10.5
database_cross_reference: HPO:HP:0004298

Abdominal wall defect
type: Class
subclass of: Abnormality of the abdominal wall
Definition: An incomplete closure of the abdominal wall.
MCID: MC00080998
PMOID: PMO:00005542
Subclass_of: Abnormality of the abdominal wall
Synonym: ABDOMINAL WALL DEFECT
Synonym: ABDOMINAL WALL DEFECTS
Synonym: Congenital anterior abdominal wall defect
Synonym: abdominal defects wall
Synonym: abdominal wall defect
Synonym: abdominal wall defects
Tree Number: T3.10.5.1
database_cross_reference: CHV:0000024059
database_cross_reference: DXP:U000059
database_cross_reference: HPO:HP:0010866
database_cross_reference: OMIM:230750

Abnormality of the abdominal musculature
type: Class
subclass of: Abnormality of the abdominal wall
Definition: An abnormality of the abdominal musculature.
MCID: MC01001536
PMOID: PMO:00005547
Subclass_of: Abnormality of the abdominal wall
Tree Number: T3.10.5.2
database_cross_reference: HPO:HP:0010991

Abnormality of the umbilicus
type: Class
subclass of: Abnormality of the abdominal wall
Definition: Abnormality of the umbilicus.
MCID: MC01396406
PMOID: PMO:00005555
Subclass_of: Abnormality of the abdominal wall
Synonym: Abnormal belly button
Synonym: Abnormal navel
Synonym: Abnormal umbilicus
Tree Number: T3.10.5.3
database_cross_reference: HPO:HP:0001551

Exstrophy
type: Class
subclass of: Abnormality of the abdominal wall
Definition: Eversion of a hollow organ and exposure, inside out, and protruded through the abdominal wall.
MCID: MC00004877
PMOID: PMO:00005558
Subclass_of: Abnormality of the abdominal wall
Synonym: Exstrophy (morphologic abnormality)
Synonym: exstrophy
Tree Number: T3.10.5.4
database_cross_reference: CHV:0000004792
database_cross_reference: HPO:HP:0100548
database_cross_reference: SNM:M-21550
database_cross_reference: SNOMEDCT_US:110407002

Prune belly
type: Class
subclass of: Abnormality of the abdominal wall
Definition: A kind of congenital defect of the anterior abdominal wall in which the intestines are evident through the thin, lax, and protruding abdominal wall in affected infants.
MCID: MC01400681
PMOID: PMO:00005560
Subclass_of: Abnormality of the abdominal wall
Tree Number: T3.10.5.5
database_cross_reference: HPO:HP:0004392

Abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the digestive system
Definition: An abnormality of the gastrointestinal tract.
MCID: MC01001529
PMOID: PMO:00005561
Subclass_of: Abnormality of the digestive system
Tree Number: T3.10.6
database_cross_reference: HPO:HP:0011024

Functional abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
Definition: Abnormal functionality of the gastrointestinal tract.
MCID: MC01001036
PMOID: PMO:00005562
Subclass_of: Abnormality of the gastrointestinal tract
Tree Number: T3.10.6.1
database_cross_reference: HPO:HP:0012719

Morphological abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
Definition: Abnormal structure of the gastrointestinal tract.
MCID: MC00999814
PMOID: PMO:00005595
Subclass_of: Abnormality of the gastrointestinal tract
Synonym: Abnormal shape of the digestive system
Synonym: Morphological anomaly of the digestive system
Tree Number: T3.10.6.2
database_cross_reference: HPO:HP:0012718

Neoplasm of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
Definition: A tumor (abnormal growth of tissue) of the gastrointestinal tract.
MCID: MC00005471
PMOID: PMO:00005793
Subclass_of: Abnormality of the gastrointestinal tract
Synonym: Digestive Neoplasm
Synonym: Digestive System Neoplasm
Synonym: Digestive System Tumor
Synonym: Digestive Tumor
Synonym: GASTROINTESTINAL NEOPL
Synonym: GASTROINTESTINAL TUMOR
Synonym: GI NEOPLASIA
Synonym: GI Neoplasm
Synonym: GI System Neoplasm
Synonym: GI System Tumor
Tree Number: T3.10.6.3
database_cross_reference: AOD:0000023051
database_cross_reference: CCPSS:0055048
database_cross_reference: CHV:0000005388
database_cross_reference: CHV:0000031018
database_cross_reference: CSP:2010-0179
database_cross_reference: CST:NEOPL GI
database_cross_reference: DXP:U001651
database_cross_reference: HPO:HP:0007378
database_cross_reference: MDR:10017986
database_cross_reference: MDR:10018238
database_cross_reference: MDR:10028978
database_cross_reference: MDR:10061174
database_cross_reference: MEDCIN:355285
database_cross_reference: MSH:D005770
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3052
database_cross_reference: NDFRT:N0000001321
database_cross_reference: RCD:Xa0DI
database_cross_reference: RCDAE:Xa0DI
database_cross_reference: SNOMEDCT_US:126768004
database_cross_reference: SNOMEDCT_US:276806006

Zollinger-Ellison syndrome
type: Class
subclass of: PMO:00025115
Definition: A condition in which there is increased production of gastrin by a gastrin-secreting tumor (usually located in the pancreas, duodenum, or abdominal lymph nodes) that stimulates the gastric mucosa to maximal activity, with consequent gastrointestinal mucosal ulceration.
Definition: A syndrome that is haracterized by the development of a one or more tumors (gastrinoma) in the pancreas, duodenum, or both that secrete excessive levels of gastrin, a hormone that stimulates production of acid by the stomach.
MCID: MC00013829
PMOID: PMO:00005824
Subclass_of: syndrome
Synonym: Excessive gastrin secretion
Synonym: Gastrinoma syndrome
Synonym: PANCREATIC ULCEROGENIC TUMOR SYNDROME
Synonym: SYNDROME ZOLLINGER ELLISON
Synonym: Syndrome Zollinger Ellison
Synonym: Syndrome, Zollinger-Ellison
Synonym: Z-E SYNDROME
Synonym: Z-E syndrome
Synonym: ZE - Zollinger-Ellison syndr
Synonym: ZE - Zollinger-Ellison syndrome
Tree Number: T10.1.24
database_cross_reference: AOD:0000005601
database_cross_reference: CCPSS:0008924
database_cross_reference: CHV:0000013282
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2014-5144
database_cross_reference: CST:ULCER PEPTIC
database_cross_reference: DO:DOID:0050782
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002039
database_cross_reference: DXP:U004506
database_cross_reference: HPO:HP:0002044
database_cross_reference: ICD10CM:E16.4
database_cross_reference: LCH:U005088
database_cross_reference: LCH_NW:sh85149946
database_cross_reference: MDR:10042855
database_cross_reference: MDR:10048253
database_cross_reference: MDR:10048281
database_cross_reference: MEDCIN:30226
database_cross_reference: MSH:D015043
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:251.5
database_cross_reference: NCI:C3453
database_cross_reference: NCI_NCI-GLOSS:CDR0000044262
database_cross_reference: NDFRT:N0000003185
database_cross_reference: OMIM:MTHU036718
database_cross_reference: RCD:C1150
database_cross_reference: SNM:D-2936
database_cross_reference: SNM:D-2939
database_cross_reference: SNMI:DB-63410
database_cross_reference: SNOMEDCT_US:154694003
database_cross_reference: SNOMEDCT_US:190443003
database_cross_reference: SNOMEDCT_US:267477002
database_cross_reference: SNOMEDCT_US:53132006

Abnormality of the ear
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the ear.
MCID: MC00091219
PMOID: PMO:00005825
Subclass_of: Phenotypic Abnormality
Synonym: 4-B0 CONGENITAL ANOMALIES OF THE EAR
Synonym: Abnormality of the external ear
Synonym: CONGENITAL ANOMALIES OF THE EAR
Synonym: Congenital abnormality of ear
Synonym: Congenital anomaly of ear
Synonym: Congenital anomaly of ear (disorder)
Synonym: Congenital anomaly of ear NOS
Synonym: Congenital anomaly of ear, NOS
Synonym: Congenital anomaly;ear
Synonym: Congenital deformity of ear
Tree Number: T3.11
database_cross_reference: CCPSS:0023368
database_cross_reference: CHV:0000026070
database_cross_reference: CST:ANOMALY CONGEN
database_cross_reference: HPO:HP:0000356
database_cross_reference: HPO:HP:0000598
database_cross_reference: ICD10:Q17.9
database_cross_reference: ICD10AM:Q17.9
database_cross_reference: ICD10CM:Q17.9
database_cross_reference: ICD9CM:744.3
database_cross_reference: ICPC2EENG:H80
database_cross_reference: ICPC2P:H80004
database_cross_reference: MDR:10010451
database_cross_reference: MDR:10014016
database_cross_reference: MDR:10014017
database_cross_reference: MDR:10045698
database_cross_reference: MEDCIN:34548
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:744.3
database_cross_reference: OMIM:128600
database_cross_reference: OMIM:MTHU006799
database_cross_reference: OMIM:MTHU034021
database_cross_reference: OMIM:MTHU053647
database_cross_reference: RCD:P43..
database_cross_reference: RCD:X77tA
database_cross_reference: RCD:XM1MC
database_cross_reference: SNMI:D4-B0000
database_cross_reference: SNOMEDCT_US:156903001
database_cross_reference: SNOMEDCT_US:156906009
database_cross_reference: SNOMEDCT_US:204262009
database_cross_reference: SNOMEDCT_US:268311006
database_cross_reference: SNOMEDCT_US:268312004
database_cross_reference: SNOMEDCT_US:275259005
database_cross_reference: SNOMEDCT_US:8380000

Abnormal ear morphology
type: Class
subclass of: Abnormality of the ear
Definition: Any structural anomaly of the ear.
MCID: MC01395867
PMOID: PMO:00005826
Subclass_of: Abnormality of the ear
Tree Number: T3.11.1
database_cross_reference: HPO:HP:0031703

Abnormality of the inner ear
type: Class
subclass of: Abnormal ear morphology
Definition: An abnormality of the inner ear.
MCID: MC01000358
PMOID: PMO:00005827
Subclass_of: Abnormal ear morphology
Synonym: Inner ear abnormality
Tree Number: T3.11.1.1
database_cross_reference: HPO:HP:0000359

Abnormality of the middle ear
type: Class
subclass of: Abnormal ear morphology
Definition: An abnormality of the middle ear.
MCID: MC01396386
PMOID: PMO:00005873
Subclass_of: Abnormal ear morphology
Synonym: Middle ear abnormalities
Synonym: Middle ear abnormality
Tree Number: T3.11.1.2
database_cross_reference: HPO:HP:0000370

Abnormality of the outer ear
type: Class
subclass of: Abnormal ear morphology
Definition: An abnormality of the external ear.
MCID: MC00608748
PMOID: PMO:00005911
Subclass_of: Abnormal ear morphology
Synonym: Abnormal pinnae
Synonym: Abnormality of the auricle
Synonym: External ear malformation
Synonym: External ear malformations
Synonym: Malformed pinnae
Synonym: Outer ear abnormality
Tree Number: T3.11.1.3
database_cross_reference: HPO:HP:0000356
database_cross_reference: HPO:HP:0008572
database_cross_reference: OMIM:MTHU000093
database_cross_reference: OMIM:MTHU003467
database_cross_reference: OMIM:MTHU019198

Aplasia/Hypoplasia of the ear
type: Class
subclass of: Abnormal ear morphology
Definition: The presence of aplasia or developmental hypoplasia of the ear.
MCID: MC01396855
PMOID: PMO:00006057
Subclass_of: Abnormal ear morphology
Synonym: Absent/small ear
Synonym: Absent/underdeveloped ear
Tree Number: T3.11.1.4
database_cross_reference: HPO:HP:0008771

Neoplasm of the ear
type: Class
subclass of: Abnormal ear morphology
Definition: A tumor (abnormal growth of tissue) of the ear.
MCID: MC00004266
PMOID: PMO:00006063
Subclass_of: Abnormal ear morphology
Synonym: EAR NEOPL
Synonym: Ear Neoplasm
Synonym: Ear Neoplasms
Synonym: Ear Neoplasms [Disease/Finding]
Synonym: Ear Tumor
Synonym: Ear neoplasm
Synonym: Ear tumor
Synonym: Ear--Tumors
Synonym: NEOPL EAR
Synonym: Neoplasm of Ear
Tree Number: T3.11.1.5
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2018-3094
database_cross_reference: DO:DOID:833
database_cross_reference: HPO:HP:0012780
database_cross_reference: ICPC2EENG:H75
database_cross_reference: ICPC2P:H75006
database_cross_reference: LCH_NW:sh85040394
database_cross_reference: MDR:10055016
database_cross_reference: MEDCIN:354965
database_cross_reference: MSH:D004428
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3000
database_cross_reference: NDFRT:N0000001037
database_cross_reference: SNOMEDCT_US:363228008

Abnormal ear physiology
type: Class
subclass of: Abnormality of the ear
Definition: Any functional anomaly of the ear.
MCID: MC01395868
PMOID: PMO:00006066
Subclass_of: Abnormality of the ear
Tree Number: T3.11.2
database_cross_reference: HPO:HP:0031704

Hearing abnormality
type: Class
subclass of: Abnormal ear physiology
Definition: An abnormality of the sensory perception of sound.
MCID: MC01003113
PMOID: PMO:00006067
Subclass_of: Abnormal ear physiology
Synonym: Abnormal hearing
Tree Number: T3.11.2.1
database_cross_reference: HPO:HP:0000364

Abnormality of the endocrine system
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the endocrine system.
MCID: MC01003086
PMOID: PMO:00006108
Subclass_of: Phenotypic Abnormality
Tree Number: T3.12
database_cross_reference: HPO:HP:0000818

Abnormal endocrine morphology
type: Class
subclass of: Abnormality of the endocrine system
Definition: Any anomaly of the structure of an organ ofthe endocrine system.
MCID: MC01395873
PMOID: PMO:00006109
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.1
database_cross_reference: HPO:HP:0031071

Abnormal endocrine physiology
type: Class
subclass of: Abnormality of the endocrine system
Definition: Any anomaly of the function of the endocrine system.
MCID: MC01395874
PMOID: PMO:00006110
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.2
database_cross_reference: HPO:HP:0031072

Abnormal response to endocrine stimulation test
type: Class
subclass of: Abnormal endocrine physiology
Definition: An anomalous response to a test that is designed to probe the function of the endocrine system.
MCID: MC01396106
PMOID: PMO:00006111
Subclass_of: Abnormal endocrine physiology
Tree Number: T3.12.2.1
database_cross_reference: HPO:HP:0031073

Abnormal response to glucagon stimulation test
type: Class
subclass of: Abnormal endocrine physiology
Definition: An anomalous response to the glucagon stimulation test, which like the insulin tolerance test (ITT) stimulates the release of both adrenocorticotropic hormone (ACTH) and growth hormone (GH).
MCID: MC01396107
PMOID: PMO:00006120
Subclass_of: Abnormal endocrine physiology
Tree Number: T3.12.2.2
database_cross_reference: HPO:HP:0031080

Abnormal response to human chorionic gonadotrophin stimulation test
type: Class
subclass of: Abnormal endocrine physiology
Definition: An anomalous response to intravenous stimulation by human chorionic gonadotrophin. Stimulation with hCG stimulates testicular Leydig cells to secrete androgens via the Leydig hormone receptors.
MCID: MC01396109
PMOID: PMO:00006124
Subclass_of: Abnormal endocrine physiology
Synonym: Abnormal response to hCG stimulation test
Tree Number: T3.12.2.3
database_cross_reference: HPO:HP:0031083

Inappropriate antidiuretic hormone secretion
type: Class
subclass of: Abnormal endocrine physiology
Definition: A state of increased circulating antidiuretic hormone despite hyponatremia and hypo-osmolality with normal or increased plasma volume.
MCID: MC00006781
PMOID: PMO:00006125
Subclass_of: Abnormal endocrine physiology
Synonym: ADH INAPPROPRIATE
Synonym: ADH INAPPROPRIATE SECRETION
Synonym: ADH Syndrome, Inappropriate
Synonym: ADH inappropriate
Synonym: ADH inappropriate secretion
Synonym: ANTIDIURETIC HORMONE INAPPROPRIATE SECRET
Synonym: Antidiuretic Hormone, Inappropriate Secretion
Synonym: INAPPROPRIATE ADH
Synonym: INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE
Synonym: INAPPROPRIATE VASOPRESSIN SECRET SYNDROME
Tree Number: T3.12.2.4
database_cross_reference: AOD:0000005977
database_cross_reference: CCPSS:0019261
database_cross_reference: CHV:0000006634
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000576
database_cross_reference: CST:ADH INAPPROP
database_cross_reference: CST:METSIADH
database_cross_reference: DO:DOID:3401
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000930
database_cross_reference: HPO:HP:0031218
database_cross_reference: ICD10:E22.2
database_cross_reference: ICD10AM:E22.2
database_cross_reference: ICD10CM:E22.2
database_cross_reference: MDR:10001270
database_cross_reference: MDR:10001271
database_cross_reference: MDR:10021585
database_cross_reference: MDR:10021586
database_cross_reference: MDR:10021587
database_cross_reference: MDR:10021598
database_cross_reference: MDR:10040626
database_cross_reference: MDR:10042818
database_cross_reference: MDR:10042828
database_cross_reference: MDR:10053198
database_cross_reference: MDR:10071644
database_cross_reference: MEDCIN:30590
database_cross_reference: MSH:D007177
database_cross_reference: MTHICD9:253.6
database_cross_reference: NCI:C3988
database_cross_reference: NCI_NICHD:C3988
database_cross_reference: NDFRT:N0000001674
database_cross_reference: OMIM:MTHU016053
database_cross_reference: RCD:C1360
database_cross_reference: SNM:D-2102
database_cross_reference: SNMI:DB-13200
database_cross_reference: SNOMEDCT_US:389983008
database_cross_reference: SNOMEDCT_US:55004003

Abnormality of circulating hormone level
type: Class
subclass of: Abnormality of the endocrine system
Definition: An abnormal concentration of a hormone in the blood.
MCID: MC01396267
PMOID: PMO:00006126
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.3
database_cross_reference: HPO:HP:0003117

Abnormal adiponectin level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: A deviation from the normal circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue, and that plays a crucial role in the regulation of insulin sensitivity and glucose metabolism.
MCID: MC01395736
PMOID: PMO:00006127
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.1
database_cross_reference: HPO:HP:0030684

Abnormal antimullerian hormone level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: Any deviation from the normal range of the antimullerian hormone, a peptide produced by the granulosa cells of follicles. Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is produced by the granulosa cells of small antral follicles of the ovary. AMH has an inhibiting role in the ovary, contributing to follicular arrest. AMH levels in women are low until the age of 8, rise rapidly until puberty and decline steadily from the age of 25 until menopause, when AMH production ceases.
MCID: MC01395750
PMOID: PMO:00006130
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.2
database_cross_reference: HPO:HP:0031101

Abnormal circulating androgen level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An anomaly in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.
MCID: MC01395813
PMOID: PMO:00006133
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.3
database_cross_reference: HPO:HP:0030347

Abnormal circulating estrogen level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: A deviation from normal concentration of the hormone estrogen in the blood circulation.
MCID: MC01395818
PMOID: PMO:00006141
Subclass_of: Abnormality of circulating hormone level
Synonym: Abnormal circulating oestrogen level
Synonym: Abnormal estrogen level
Tree Number: T3.12.3.4
database_cross_reference: HPO:HP:0025132

Abnormal circulating gonadotropin level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An anomaly of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
MCID: MC01395822
PMOID: PMO:00006151
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.5
database_cross_reference: HPO:HP:0030338

Abnormal circulating inhibin level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: Any deviation from the normal concentration of iInhibins, which are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. Inhibins suppress the secretion of pituitary follicle-stimulating hormone.
MCID: MC01395824
PMOID: PMO:00006157
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.6
database_cross_reference: HPO:HP:0031099

Abnormal circulating osteocalcin level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: A deviation from the normal concentration of osteocalcin in the blood circulation.
MCID: MC01395828
PMOID: PMO:00006159
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.7
database_cross_reference: HPO:HP:0031427

Abnormal circulating progesterone level
type: Class
subclass of: Abnormality of circulating hormone level
MCID: MC01395829
PMOID: PMO:00006162
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.8
database_cross_reference: HPO:HP:0031212

Abnormal glucagon level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: A deviation from the normal concentration of glucagon in the blood circulation.
MCID: MC01395904
PMOID: PMO:00006166
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.9
database_cross_reference: HPO:HP:0030687

Abnormal insulin level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An abnormal concentration of insulin in the body.
MCID: MC01395941
PMOID: PMO:00006169
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.10
database_cross_reference: HPO:HP:0040214

Abnormal serum insulin-like growth factor 1 level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An anomalous level of insulin-like growth factor 1 (IGF1) in the blood circulation.
MCID: MC01396128
PMOID: PMO:00006172
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.11
database_cross_reference: HPO:HP:0030352

Abnormality of circulating adrenocorticotropin level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An abnormal concentration of corticotropin in the blood.
MCID: MC01396261
PMOID: PMO:00006175
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.12
database_cross_reference: HPO:HP:0011043

Abnormality of circulating catecholamine level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An abnormal catecholamine concentration in the blood.
MCID: MC01396263
PMOID: PMO:00006178
Subclass_of: Abnormality of circulating hormone level
Synonym: Catecholamine levels abnormal
Tree Number: T3.12.3.13
database_cross_reference: HPO:HP:0012099

Abnormality of circulating glucocorticoid level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An abnormality of the concentration of a glucocorticoid in the blood.
MCID: MC01001176
PMOID: PMO:00006180
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.14
database_cross_reference: HPO:HP:0012111

Abnormality of circulating leptin level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An abnormal concentration of leptin in the blood.
MCID: MC01396268
PMOID: PMO:00006185
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.15
database_cross_reference: HPO:HP:0004361

Abnormality of circulating pregnenolone level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An abnormality of the concentration of pregnenolone in the blood.
MCID: MC01396269
PMOID: PMO:00006188
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.16
database_cross_reference: HPO:HP:0031187

Abnormality of gonadotropin-releasing hormone level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: A deviation from the normal circulating concentration of the normal gonadotropin-releasing hormone level secreted from the pituitary gland.
MCID: MC01396303
PMOID: PMO:00006189
Subclass_of: Abnormality of circulating hormone level
Synonym: Abnormality of GnRH level
Tree Number: T3.12.3.17
database_cross_reference: HPO:HP:0500012

Decreased circulating dehydroepiandrosterone level
type: Class
subclass of: Abnormality of circulating hormone level
MCID: MC01397524
PMOID: PMO:00006191
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.18
database_cross_reference: HPO:HP:0031214

Decreased circulating dehydroepiandrosterone-sulfate level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: A reduced concentration of dehydroepiandrosterone-sulfate in the blood.
MCID: MC01397525
PMOID: PMO:00006192
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.19
database_cross_reference: HPO:HP:0031215

Elevated vascular endothelial growth factor level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: Increased blood concentration of vascular endothelial growth factor (VEGF).
MCID: MC01398118
PMOID: PMO:00006193
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.20
database_cross_reference: HPO:HP:0031052

Fasting hypoglycemia
type: Class
subclass of: Abnormality of circulating hormone level
MCID: MC00095125
PMOID: PMO:00006194
Subclass_of: Abnormality of circulating hormone level
Synonym: Fasting Hypoglycemia
Synonym: Fasting hypoglycaemia
Synonym: Fasting hypoglycemia (disorder)
Synonym: Hypoglycemia, Fasting
Synonym: Hypoglycemia, Postabsorptive
Synonym: Low blood sugar when fasting
Synonym: Postabsorptive Hypoglycemia
Synonym: fasting hypoglycemia
Tree Number: T3.12.3.21
database_cross_reference: CHV:0000026660
database_cross_reference: HPO:HP:0003162
database_cross_reference: MDR:10078708
database_cross_reference: MDR:10078719
database_cross_reference: MSH:D007003
database_cross_reference: OMIM:MTHU011882
database_cross_reference: RCD:X40K2
database_cross_reference: RCDAE:X40K2
database_cross_reference: SNMI:DB-63220
database_cross_reference: SNOMEDCT_US:6974005

Growth hormone deficiency
type: Class
subclass of: Abnormality of circulating hormone level
Definition: Insufficient production of growth hormone, which is produced by the anterior pituitary gland. Growth hormone is a major participant in control of growth and metabolism.
MCID: MC00095003
PMOID: PMO:00006195
Subclass_of: Abnormality of circulating hormone level
Synonym: GHD
Synonym: GHD - Growth hormon deficiency
Synonym: GHD - Growth hormone deficiency
Synonym: Growth hormone deficiency (disorder)
Synonym: Growth hormone deficiency, NOS
Synonym: Growth hormone insufficiency
Synonym: STH deficiency
Synonym: Somatotropin Deficiency
Synonym: Somatotropin deficiency
Synonym: Somatotropin deficiency (disorder)
Tree Number: T3.12.3.22
database_cross_reference: CHV:0000026643
database_cross_reference: CSP:2715-1517
database_cross_reference: MDR:10056438
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C102986
database_cross_reference: NCI_NICHD:C102986
database_cross_reference: OMIM:MTHU004822
database_cross_reference: RCD:Xa9Ap
database_cross_reference: SNMI:DB-12500
database_cross_reference: SNOMEDCT_US:154702001
database_cross_reference: SNOMEDCT_US:302867007
database_cross_reference: SNOMEDCT_US:397827003
database_cross_reference: SNOMEDCT_US:44008002

Increased pituitary glycoprotein alpha subunit level
type: Class
subclass of: Abnormality of circulating hormone level
Definition: An increased concentration of circulating alpha polypeptide of glycoprotein hormones (Entrez Gene 1081). This alpha subunit is common to luteinizing hormone (LH) , follicle stimulating hormone (FSH) , thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), which are glycoprotein hormones composed of an identical alpha subunit together with a beta subunit that confers biological specificity. The alpha subunit is used as a marker for tumors that produce these hormones.
MCID: MC01399162
PMOID: PMO:00006197
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.23
database_cross_reference: HPO:HP:0031208

Increased serum 1,25-dihydroxyvitamin D3
type: Class
subclass of: Abnormality of circulating hormone level
MCID: MC01399196
PMOID: PMO:00006198
Subclass_of: Abnormality of circulating hormone level
Synonym: Increased serum calcitriol
Tree Number: T3.12.3.24
database_cross_reference: HPO:HP:0003152

Increased serum serotonin
type: Class
subclass of: Abnormality of circulating hormone level
Definition: A increased concentration of serotonin in the blood.
MCID: MC01399215
PMOID: PMO:00006199
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.25
database_cross_reference: HPO:HP:0003144

Abnormality of renin-angiotensin system
type: Class
subclass of: Abnormality of the endocrine system
Definition: An abnormality of the renin-angiotensin system.
MCID: MC01000343
PMOID: PMO:00006200
Subclass_of: Abnormality of the endocrine system
Synonym: Abnormality of the renin-aldosterone axis
Tree Number: T3.12.4
database_cross_reference: HPO:HP:0000847

Abnormal circulating aldosterone
type: Class
subclass of: Abnormality of renin-angiotensin system
MCID: MC01395812
PMOID: PMO:00006201
Subclass_of: Abnormality of renin-angiotensin system
Synonym: Abnormal plasma aldosterone
Tree Number: T3.12.4.1
database_cross_reference: HPO:HP:0040085

Abnormal circulating renin
type: Class
subclass of: Abnormality of renin-angiotensin system
MCID: MC00999798
PMOID: PMO:00006202
Subclass_of: Abnormality of renin-angiotensin system
Synonym: Abnormal plasma renin
Tree Number: T3.12.4.2
database_cross_reference: HPO:HP:0040084

Hyperactive renin-angiotensin system
type: Class
subclass of: Abnormality of renin-angiotensin system
Definition: An abnormally increased activity of the renin-angiotensin system, causing hypertension by a combination of volume excess and vasoconstrictor mechanisms.
MCID: MC01398662
PMOID: PMO:00006205
Subclass_of: Abnormality of renin-angiotensin system
Tree Number: T3.12.4.3
database_cross_reference: HPO:HP:0000841

Abnormality of the adrenal glands
type: Class
subclass of: Abnormality of the endocrine system
Definition: Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kindneys.
MCID: MC01000344
PMOID: PMO:00006206
Subclass_of: Abnormality of the endocrine system
Synonym: Adrenal abnormalities
Tree Number: T3.12.5
database_cross_reference: HPO:HP:0000834

Abnormality of adrenal morphology
type: Class
subclass of: Abnormality of the adrenal glands
Definition: Any structural anomaly of the adrenal glands.
MCID: MC01001279
PMOID: PMO:00006207
Subclass_of: Abnormality of the adrenal glands
Tree Number: T3.12.5.1
database_cross_reference: HPO:HP:0011732

Abnormality of adrenal physiology
type: Class
subclass of: Abnormality of the adrenal glands
Definition: A functional abnormality of the adrenal glands.
MCID: MC01001278
PMOID: PMO:00006229
Subclass_of: Abnormality of the adrenal glands
Tree Number: T3.12.5.2
database_cross_reference: HPO:HP:0011733

Abnormality of the hypothalamus-pituitary axis
type: Class
subclass of: Abnormality of the endocrine system
Definition: Abnormality of the pituitary gland (also known as hypophysis), which is an endocrine gland that protrudes from the bottom of the hypothalamus at the base of the brain. The pituitary gland secretes the hormones ACTH, TSH, PRL, GH, endorphins, FSH, LH, oxytocin, and antidiuretic hormone. The secretion of hormones from the anterior pituitary is under the strict control of hypothalamic hormones, and the posterior pituitary is essentially an extension of the hypothalamus, so that hypothalamus and pituitary gland may be regarded as a functional unit.
MCID: MC01003082
PMOID: PMO:00006250
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.6
database_cross_reference: HPO:HP:0000864

Abnormal hypothalamus physiology
type: Class
subclass of: Abnormality of the hypothalamus-pituitary axis
Definition: An abnormal functionality of the hypothalamus.
MCID: MC01001133
PMOID: PMO:00006251
Subclass_of: Abnormality of the hypothalamus-pituitary axis
Tree Number: T3.12.6.1
database_cross_reference: HPO:HP:0012285

Abnormality of the parathyroid gland
type: Class
subclass of: Abnormality of the endocrine system
Definition: An abnormality of the parathyroid gland.
MCID: MC01003085
PMOID: PMO:00006255
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.7
database_cross_reference: HPO:HP:0000828

Abnormality of the parathyroid morphology
type: Class
subclass of: Abnormality of the parathyroid gland
Definition: A structural abnormality of the parathyroid gland.
MCID: MC01001266
PMOID: PMO:00006256
Subclass_of: Abnormality of the parathyroid gland
Tree Number: T3.12.7.1
database_cross_reference: HPO:HP:0011766

Abnormality of the parathyroid physiology
type: Class
subclass of: Abnormality of the parathyroid gland
Definition: A functional abnormality of the parathyroid gland.
MCID: MC01001265
PMOID: PMO:00006262
Subclass_of: Abnormality of the parathyroid gland
Tree Number: T3.12.7.2
database_cross_reference: HPO:HP:0011767

Abnormality of the pineal gland
type: Class
subclass of: Abnormality of the endocrine system
Definition: An anomaly of the pineal gland,a small endocrine gland in the brain that produces melatonin.
MCID: MC01001049
PMOID: PMO:00006271
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.8
database_cross_reference: HPO:HP:0012680

Abnormality of pineal morphology
type: Class
subclass of: Abnormality of the pineal gland
Definition: A structural abnormality of the pineal gland.
MCID: MC01001048
PMOID: PMO:00006272
Subclass_of: Abnormality of the pineal gland
Tree Number: T3.12.8.1
database_cross_reference: HPO:HP:0012681

Abnormality of pineal physiology
type: Class
subclass of: Abnormality of the pineal gland
Definition: A functional abnormality of the pineal gland.
MCID: MC01001046
PMOID: PMO:00006278
Subclass_of: Abnormality of the pineal gland
Tree Number: T3.12.8.2
database_cross_reference: HPO:HP:0012688

Abnormality of the thymus
type: Class
subclass of: Abnormality of the endocrine system
Definition: Abnormality of the thymus, an organ located in the upper anterior portion of the chest cavity just behind the sternum and whose main function is to provide an environment for T lymphocyte maturation.
MCID: MC00088186
PMOID: PMO:00006280
Subclass_of: Abnormality of the endocrine system
Synonym: THYMUS ABNORMALITY
Tree Number: T3.12.9
database_cross_reference: COSTAR:U000584
database_cross_reference: HPO:HP:0000777

Aplasia/Hypoplasia of the thymus
type: Class
subclass of: Abnormality of the thymus
Definition: Absence or underdevelopment of the thymus.
MCID: MC01001632
PMOID: PMO:00006281
Subclass_of: Abnormality of the thymus
Synonym: Absent/small thymus
Synonym: Absent/underdeveloped thymus
Tree Number: T3.12.9.1
database_cross_reference: HPO:HP:0010515

Ectopic thymus tissue
type: Class
subclass of: Abnormality of the thymus
Definition: The presence of ectopic thymus tissue. Normally, cells of the ventral bud of the third pharyngeal pouch detach and migrate in the eighth gestational week caudally and medially towards the location of the mature thyroid. They migrate further retrosternally into the superior mediastinum. There are two main ways ectopic thymus tissue can develop. Either cells detach along the descensus path and proliferate, thereby forming accessory thymus tissue, or the entire gland fails to descend.
MCID: MC01397951
PMOID: PMO:00006284
Subclass_of: Abnormality of the thymus
Synonym: Abnormal thymus position
Tree Number: T3.12.9.2
database_cross_reference: HPO:HP:0010517

Neoplasm of the thymus
type: Class
subclass of: Abnormality of the thymus
Definition: A tumor (abnormal growth of tissue) of the thymus.
MCID: MC00958060
PMOID: PMO:00006285
Subclass_of: Abnormality of the thymus
Synonym: NEOPL THYMIC
Synonym: NEOPL THYMUS
Synonym: Neoplasm of Thymus
Synonym: Neoplasm of the Thymus
Synonym: Neoplasm of thymus
Synonym: Neoplasm of thymus (disorder)
Synonym: Neoplasm, Thymic
Synonym: Neoplasm, Thymus
Synonym: Neoplasms, Thymic
Synonym: Neoplasms, Thymus
Tree Number: T3.12.9.3
database_cross_reference: AOD:0000023100
database_cross_reference: CHV:0000012253
database_cross_reference: CSP:2004-8826
database_cross_reference: HPO:HP:0100521
database_cross_reference: LCH_NW:sh85135150
database_cross_reference: MDR:10056296
database_cross_reference: MEDCIN:97141
database_cross_reference: MSH:D013953
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3412
database_cross_reference: NDFRT:N0000002939
database_cross_reference: RCD:X40Om
database_cross_reference: RCDAE:X40Om
database_cross_reference: SNOMEDCT_US:127231009
database_cross_reference: SNOMEDCT_VET:127231009

Thymic hormone decreased
type: Class
subclass of: Abnormality of the thymus
Definition: A reduction in the level of thymic horomone.
MCID: MC01401502
PMOID: PMO:00006287
Subclass_of: Abnormality of the thymus
Synonym: Decreased thymic hormone
Tree Number: T3.12.9.4
database_cross_reference: HPO:HP:0003357

Thymus hyperplasia
type: Class
subclass of: Abnormality of the thymus
Definition: Enlargement of the thymus.
MCID: MC00012823
PMOID: PMO:00006288
Subclass_of: Abnormality of the thymus
Synonym: Enlarged thymus
Synonym: Gland Hyperplasia, Thymus
Synonym: Gland Hyperplasias, Thymus
Synonym: Hyperplasia of Thymus Gland
Synonym: Hyperplasia, Thymic
Synonym: Hyperplasia, Thymus
Synonym: Hyperplasias, Thymic
Synonym: Thymic Hyperplasia
Synonym: Thymic Hyperplasias
Synonym: Thymus Gland Hyperplasia
Tree Number: T3.12.9.5
database_cross_reference: CHV:0000012252
database_cross_reference: HPO:HP:0010516
database_cross_reference: MSH:D013952
database_cross_reference: NDFRT:N0000002938

Abnormality of the thyroid gland
type: Class
subclass of: Abnormality of the endocrine system
Definition: An abnormality of the thyroid gland.
MCID: MC00012829
PMOID: PMO:00006289
Subclass_of: Abnormality of the endocrine system
Synonym: B-80 HYPOTHYROIDISM, HYPERTHYROIDISM AND OTHER DISORDERS
Synonym: DISEASES OF THE THYROID GLAND
Synonym: DISORDER THYROID
Synonym: DISORDERS OF THYROID GLAND
Synonym: Disease of thyroid gland
Synonym: Disease of thyroid gland (disorder)
Synonym: Disease of thyroid gland, NOS
Synonym: Disease, Thyroid
Synonym: Diseases of Thyroid Gland
Synonym: Diseases of the thyroid gland
Tree Number: T3.12.10
database_cross_reference: AOD:0000005981
database_cross_reference: CCPSS:0034188
database_cross_reference: CCPSS:0056633
database_cross_reference: CHV:0000012259
database_cross_reference: CHV:0000048209
database_cross_reference: COSTAR:U000061
database_cross_reference: COSTAR:U000674
database_cross_reference: CSP:2928-6228
database_cross_reference: CST:ENDO/THYR
database_cross_reference: CST:THYR DIS
database_cross_reference: DO:DOID:12176
database_cross_reference: DO:DOID:50
database_cross_reference: HPO:HP:0000820
database_cross_reference: ICD10:E00-E07.9
database_cross_reference: ICD10:E07.9
database_cross_reference: ICD10AM:E00-E07.9
database_cross_reference: ICD10AM:E07.9
database_cross_reference: ICD10CM:E00-E07
database_cross_reference: ICD10CM:E07.9
database_cross_reference: ICD9CM:240-246.99
database_cross_reference: ICD9CM:246.9
database_cross_reference: LCH_NW:sh85135167
database_cross_reference: LNC:LA15157-3
database_cross_reference: LNC:LA17778-4
database_cross_reference: MDR:10013274
database_cross_reference: MDR:10043709
database_cross_reference: MDR:10043710
database_cross_reference: MDR:10043739
database_cross_reference: MDR:10045832
database_cross_reference: MEDCIN:90715
database_cross_reference: MEDLINEPLUS:439
database_cross_reference: MSH:D013959
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26893
database_cross_reference: NDFRT:N0000002942
database_cross_reference: OMIM:MTHU018343
database_cross_reference: OMIM:MTHU053945
database_cross_reference: PSY:53090
database_cross_reference: RCD:C06z.
database_cross_reference: RCD:XE100
database_cross_reference: SNM:D-2180
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DB-80000
database_cross_reference: SNOMEDCT_US:14304000
database_cross_reference: SNOMEDCT_US:154649009
database_cross_reference: SNOMEDCT_US:190232008
database_cross_reference: SNOMEDCT_US:190311002
database_cross_reference: SNOMEDCT_US:191036006

Abnormality of thyroid morphology
type: Class
subclass of: Abnormality of the thyroid gland
Definition: A structural abnormality of the thyroid gland.
MCID: MC01001262
PMOID: PMO:00006290
Subclass_of: Abnormality of the thyroid gland
Synonym: Abnormal shape of thyroid gland
Tree Number: T3.12.10.1
database_cross_reference: HPO:HP:0011772

Abnormality of thyroid physiology
type: Class
subclass of: Abnormality of the thyroid gland
Definition: An abnormal functionality of the thyroid gland.
MCID: MC01396412
PMOID: PMO:00006326
Subclass_of: Abnormality of the thyroid gland
Synonym: Abnormal thyroid function
Tree Number: T3.12.10.2
database_cross_reference: HPO:HP:0002926

Abnormality of urine hormone level
type: Class
subclass of: Abnormality of the endocrine system
Definition: An abnormal concentration of a hormone in the urine.
MCID: MC01396424
PMOID: PMO:00006357
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.11
database_cross_reference: HPO:HP:0012029

High urinary gonadotropin level
type: Class
subclass of: Abnormality of urine hormone level
Definition: An elevated concentration of a gonadotropin hormone (stimulating hormone or luteinizing hormone) in the urine, consistent with the diagnosis of primary hypogonadism.
MCID: MC01398626
PMOID: PMO:00006358
Subclass_of: Abnormality of urine hormone level
Tree Number: T3.12.11.1
database_cross_reference: HPO:HP:0003492

Diabetes insipidus
type: Class
subclass of: Abnormality of the endocrine system
Definition: A state of excessive water intake and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus).
MCID: MC00003794
PMOID: PMO:00006359
Subclass_of: Abnormality of the endocrine system
Synonym: DI
Synonym: DI - Diabetes insipidus
Synonym: DIABETES INSIPIDUS
Synonym: Diabetes Insipidus
Synonym: Diabetes Insipidus [Disease/Finding]
Synonym: Diabetes insipidus (disorder)
Synonym: Diabetes insipidus, NOS
Synonym: diabete insipidus
Synonym: diabetes insipidus
Tree Number: T3.12.12
database_cross_reference: CCPSS:0056411
database_cross_reference: CHV:0000003833
database_cross_reference: CHV:0000044128
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-2602
database_cross_reference: CST:DIABETES INSIPID
database_cross_reference: DO:DOID:9409
database_cross_reference: DXP:U000959
database_cross_reference: HPO:HP:0000873
database_cross_reference: ICD10:E23.2
database_cross_reference: ICD10AM:E23.2
database_cross_reference: ICD10CM:E23.2
database_cross_reference: ICD9CM:253.5
database_cross_reference: ICPC2P:T99011
database_cross_reference: MDR:10012599
database_cross_reference: MEDLINEPLUS:3046
database_cross_reference: MSH:D003919
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C43263
database_cross_reference: NCI_NICHD:C43263
database_cross_reference: NDFRT:N0000000949
database_cross_reference: OMIM:MTHU013463
database_cross_reference: PSY:13960
database_cross_reference: RCD:XE10Y
database_cross_reference: SNM:D-2101
database_cross_reference: SNMI:DB-13100
database_cross_reference: SNOMEDCT_US:15771004
database_cross_reference: SNOMEDCT_US:190484000

Central diabetes insipidus
type: Class
subclass of: Diabetes insipidus
Definition: A form of diabetes insipidus related to a failure of vasopressin (AVP) release from the hypothalamus.
MCID: MC00226882
PMOID: PMO:00006360
Subclass_of: Diabetes insipidus
Synonym: Antidiuretic hormone deficiency
Synonym: CDI
Synonym: Central Diabetes Insipidus
Synonym: Central diabetes insipidus (disorder)
Synonym: Central diabetes insipidus [Ambiguous]
Synonym: Cranial diabetes insipidus
Synonym: DIABETES INSIPIDUS, CRANIAL TYPE
Synonym: DIABETES INSIPIDUS, NEUROHYPOPHYSEAL
Synonym: DIABETES INSIPIDUS, NEUROHYPOPHYSEAL TYPE
Synonym: DIABETES INSIPIDUS, PRIMARY CENTRAL
Tree Number: T3.12.12.1
database_cross_reference: CHV:0000044128
database_cross_reference: CSP:1849-2602
database_cross_reference: DO:DOID:12388
database_cross_reference: DXP:U000469
database_cross_reference: HPO:HP:0000863
database_cross_reference: MDR:10049518
database_cross_reference: MDR:10068587
database_cross_reference: MDR:10073192
database_cross_reference: MDR:10078568
database_cross_reference: MEDCIN:30492
database_cross_reference: MSH:D020790
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:253.5
database_cross_reference: NCI:C84933
database_cross_reference: NCI_NICHD:C84933
database_cross_reference: NDFRT:N0000004189
database_cross_reference: OMIM:125700
database_cross_reference: OMIM:192340
database_cross_reference: OMIM:304900
database_cross_reference: OMIM:MTHU004824
database_cross_reference: OMIM:MTHU054071
database_cross_reference: RCD:XE10Y
database_cross_reference: SNM:D-2103
database_cross_reference: SNMI:DB-13110
database_cross_reference: SNMI:DB-13144
database_cross_reference: SNOMEDCT_US:154699008
database_cross_reference: SNOMEDCT_US:15771004
database_cross_reference: SNOMEDCT_US:190484000
database_cross_reference: SNOMEDCT_US:267393007
database_cross_reference: SNOMEDCT_US:45369008
database_cross_reference: SNOMEDCT_US:64410003

Nephrogenic diabetes insipidus
type: Class
subclass of: Diabetes insipidus
Definition: A form of diabetes insipidus caused by failure of the kidneys to respond to vasopressin (AVP).
MCID: MC00063226
PMOID: PMO:00006361
Subclass_of: Diabetes insipidus
Synonym: DIABETES INSIPIDUS NEPHROGENIC
Synonym: DIABETES INSIPIDUS, NEPHROGENIC
Synonym: Diabetes Insipidus, Nephrogenic
Synonym: Diabetes Insipidus, Nephrogenic [Disease/Finding]
Synonym: Diabetes insipidus nephrogenic
Synonym: NDI - Nephrogen diab insipidus
Synonym: NDI - Nephrogenic diabetes insipidus
Synonym: Nephrogen diabetes insip
Synonym: Nephrogenic Diabetes Insipidus
Synonym: Nephrogenic diabetes insipidus (disorder)
Tree Number: T3.12.12.2
database_cross_reference: CCPSS:0014348
database_cross_reference: CHV:0000017777
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-2659
database_cross_reference: CST:DIABETES INSIPID
database_cross_reference: DO:DOID:12387
database_cross_reference: DXP:U000468
database_cross_reference: HPO:HP:0009806
database_cross_reference: ICD10:N25.1
database_cross_reference: ICD10AM:N25.1
database_cross_reference: ICD10CM:N25.1
database_cross_reference: ICD9CM:588.1
database_cross_reference: MDR:10012600
database_cross_reference: MDR:10029147
database_cross_reference: MEDCIN:30493
database_cross_reference: MSH:D018500
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84919
database_cross_reference: NCI_NICHD:C84919
database_cross_reference: NDFRT:N0000003831
database_cross_reference: RCD:K081.
database_cross_reference: SNMI:D6-98326
database_cross_reference: SNOMEDCT_US:111395007
database_cross_reference: SNOMEDCT_US:123294004

Diabetes mellitus
type: Class
subclass of: Abnormality of the endocrine system
Definition: A group of abnormalities characterized by hyperglycemia and glucose intolerance.
MCID: MC00003795
PMOID: PMO:00006362
Subclass_of: Abnormality of the endocrine system
Synonym: DIABETES MELLITUS
Synonym: DIABETES MELLITUS NOS
Synonym: DIABETES MELLITUS NOS DIAGNOSED
Synonym: DM
Synonym: DM - Diabetes mellitus
Synonym: Diabetes
Synonym: Diabetes Mellitus
Synonym: Diabetes Mellitus [Disease/Finding]
Synonym: Diabetes Melllitus
Synonym: Diabetes NOS
Tree Number: T3.12.13
database_cross_reference: AOD:0000000009
database_cross_reference: AOD:0000005999
database_cross_reference: BI:BI00008
database_cross_reference: CCPSS:0031767
database_cross_reference: CCPSS:0041405
database_cross_reference: CCPSS:1018264
database_cross_reference: CHV:0000003834
database_cross_reference: COSTAR:230
database_cross_reference: CSP:0862-6160
database_cross_reference: CST:DIABETES MELL
database_cross_reference: DO:DOID:9351
database_cross_reference: DXP:U000960
database_cross_reference: HPO:HP:0000819
database_cross_reference: ICD10:E10-E14.9
database_cross_reference: ICD10:E14
database_cross_reference: ICD10AM:E10-E14.9
database_cross_reference: ICD10AM:E14
database_cross_reference: ICD10CM:E08-E13
database_cross_reference: ICD9CM:250
database_cross_reference: ICPC2P:T90002
database_cross_reference: LNC:LA14291-1
database_cross_reference: LNC:MTHU020781
database_cross_reference: MDR:10012594
database_cross_reference: MDR:10012601
database_cross_reference: MDR:10012614
database_cross_reference: MEDCIN:30479
database_cross_reference: MEDLINEPLUS:4
database_cross_reference: MEDLINEPLUS:45
database_cross_reference: MSH:D003920
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000263
database_cross_reference: MTHICD9:250.0
database_cross_reference: NCI:C2985
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044129
database_cross_reference: NCI_NCI-GLOSS:CDR0000044911
database_cross_reference: NCI_NICHD:C2985
database_cross_reference: NDFRT:N0000000950
database_cross_reference: OMIM:MTHU036798
database_cross_reference: PSY:13970
database_cross_reference: RCD:C10..
database_cross_reference: SNM:D-2381
database_cross_reference: SNMI:DB-61000
database_cross_reference: SNOMEDCT_US:154671004
database_cross_reference: SNOMEDCT_US:191044006
database_cross_reference: SNOMEDCT_US:267467004
database_cross_reference: SNOMEDCT_US:73211009

Diabetic ketoacidosis
type: Class
subclass of: Diabetes mellitus
Definition: A type of diabetic metabolic abnormality with an accumulation of ketone bodies.
MCID: MC00003804
PMOID: PMO:00006363
Subclass_of: Diabetes mellitus
Synonym: ACIDOSIS DIABETIC
Synonym: ACIDOSIS, DIABETIC
Synonym: Acidoses, Diabetic
Synonym: Acidosis diabetic
Synonym: Acidosis, Diabetic
Synonym: DIABETES MELLITUS, KETOSIS-PRONE
Synonym: DIABETIC ACIDOSIS
Synonym: DKA
Synonym: DKA - Diabetic ketoacidosis
Synonym: DKA - diabetic ketoacidosis
Tree Number: T3.12.13.1
database_cross_reference: AOD:0000005829
database_cross_reference: CCPSS:1017906
database_cross_reference: CHV:0000003844
database_cross_reference: CHV:0000037747
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0862-6200
database_cross_reference: CST:ACIDOSIS DIABET
database_cross_reference: DO:DOID:1837
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000969
database_cross_reference: DXP:U002245
database_cross_reference: HPO:HP:0001953
database_cross_reference: ICD9CM:250.1
database_cross_reference: LCH_NW:sh85037467
database_cross_reference: MDR:10000488
database_cross_reference: MDR:10012622
database_cross_reference: MDR:10012632
database_cross_reference: MDR:10012642
database_cross_reference: MDR:10012671
database_cross_reference: MDR:10012673
database_cross_reference: MDR:10023380
database_cross_reference: MEDCIN:30483
database_cross_reference: MSH:D016883
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000381
database_cross_reference: NCI:C50530
database_cross_reference: NCI_FDA:2364
database_cross_reference: NCI_NICHD:C50530
database_cross_reference: NDFRT:N0000003499
database_cross_reference: OMIM:MTHU010100
database_cross_reference: RCD:C101.
database_cross_reference: RCD:C101z
database_cross_reference: SNM:D-2394
database_cross_reference: SNMI:DB-62010
database_cross_reference: SNOMEDCT_US:154671004
database_cross_reference: SNOMEDCT_US:190328004
database_cross_reference: SNOMEDCT_US:24927004
database_cross_reference: SNOMEDCT_US:267467004
database_cross_reference: SNOMEDCT_US:420422005

Insulin-resistant diabetes mellitus
type: Class
subclass of: Diabetes mellitus
Definition: A type of diabetes mellitus related not to lack of insulin but rather to lack of response to insulin on the part of the target tissues of insulin such as muscle, fat, and liver cells. This type of diabetes is typically associated with increases both in blood glucose concentrations as will as in fasting and postprandial serum insulin levels.
MCID: MC00297737
PMOID: PMO:00006364
Subclass_of: Diabetes mellitus
Synonym: DIABETES MELLITUS NOS INSULIN RESISTANT
Synonym: DIABETES MELLITUS, INSULIN-RESISTANT
Synonym: Diabetes mellitus, insulin-resistant
Synonym: Insulin resistant diabetes
Synonym: Insulin resistant diabetes mellitus
Synonym: Insulin-resistant diabetes
Synonym: diabetes insulin resistant
Synonym: diabetes resistant insulin
Synonym: insulin resistant diabetes
Synonym: insulin resistant diabetes (mellitus)
Tree Number: T3.12.13.2
database_cross_reference: CCPSS:0026066
database_cross_reference: CHV:0000050224
database_cross_reference: HPO:HP:0000831
database_cross_reference: ICD10CM:E11
database_cross_reference: MDR:10022491
database_cross_reference: OMIM:147670
database_cross_reference: OMIM:MTHU002022
database_cross_reference: OMIM:MTHU009476
database_cross_reference: OMIM:MTHU009666
database_cross_reference: OMIM:MTHU010099
database_cross_reference: OMIM:MTHU034767

Maturity-onset diabetes of the young
type: Class
subclass of: Diabetes mellitus
Definition: The term Maturity-onset diabetes of the young (MODY) was initially used for patients diagnosed with fasting hyperglycemia that could be treated without insulin for more than two years, where the initial diagnosis was made at a young age (under 25 years). Thus, MODY combines characteristics of type 1 diabetes (young age at diagnosis) and type 2 diabetes (less insulin dependence than type 1 diabetes). The term MODY is now most often used to refer to a group of monogenic diseases with these characteristics. Here, the term is used to describe hyperglycemia diagnosed at a young age with no or minor insulin dependency, no evidence of insulin resistence, and lack of evidence of autoimmune destruction of the beta cells.
MCID: MC00120218
PMOID: PMO:00006368
Subclass_of: Diabetes mellitus
Synonym: Autosomal dominant diabetes mellitus
Synonym: Diab mell aut dom
Synonym: Diabetes mellitus autosomal dominant
Synonym: Diabetes mellitus autosomal dominant (disorder)
Synonym: Diabetes, maturity-onset, of the young (MODY)
Synonym: MASON-TYPE DIABETES
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG
Synonym: MODY
Synonym: MODY - Maturity onset diabetes in youth type 1
Synonym: MODY - Maturity onset diabetes in youth type I
Tree Number: T3.12.13.3
database_cross_reference: CHV:0000030749
database_cross_reference: DO:DOID:0050524
database_cross_reference: HPO:HP:0004904
database_cross_reference: MDR:10026948
database_cross_reference: MEDCIN:358414
database_cross_reference: MSH:C562772
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C114769
database_cross_reference: OMIM:606391
database_cross_reference: OMIM:MTHU039842
database_cross_reference: RCD:X40JI
database_cross_reference: SNMI:DB-61040
database_cross_reference: SNOMEDCT_US:28453007
database_cross_reference: SNOMEDCT_US:390715006
database_cross_reference: SNOMEDCT_US:400971001
database_cross_reference: SNOMEDCT_US:609561005

Type I diabetes mellitus
type: Class
subclass of: Diabetes mellitus
Definition: A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin.
MCID: MC00003796
PMOID: PMO:00006369
Subclass_of: Diabetes mellitus
Synonym: -- Diabetes Type 1
Synonym: Brittle Diabetes Mellitus
Synonym: DIABETES MELLITUS (JUVENILE ONSET)
Synonym: DIABETES MELLITUS INSULIN DEPENDENT
Synonym: DIABETES MELLITUS TYPE 01
Synonym: DIABETES MELLITUS, INSULIN DEPENDENT
Synonym: DIABETES MELLITUS, INSULIN-DEPENDENT
Synonym: DIABETES MELLITUS, INSULIN-DEPENDENT, 1
Synonym: DIABETES MELLITUS, KETOSIS-PRONE
Synonym: DIABETES MELLITUS, TYPE 1
Tree Number: T3.12.13.4
database_cross_reference: BI:BI00334
database_cross_reference: BI:BI00335
database_cross_reference: BI:BI00338
database_cross_reference: BI:BI00363
database_cross_reference: CCPSS:1017903
database_cross_reference: CHV:0000003835
database_cross_reference: COSTAR:U000228
database_cross_reference: COSTAR:U000229
database_cross_reference: CSP:0862-6800
database_cross_reference: DO:DOID:0110748
database_cross_reference: DO:DOID:9744
database_cross_reference: DRUGBANK:DB05382
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000471
database_cross_reference: HPO:HP:0100651
database_cross_reference: ICD10:E10
database_cross_reference: ICD10AM:E10
database_cross_reference: ICD10CM:E10
database_cross_reference: ICPC2EENG:T89
database_cross_reference: ICPC2P:T89001
database_cross_reference: ICPC2P:T89002
database_cross_reference: ICPC2P:T89003
database_cross_reference: ICPC2P:T90004
database_cross_reference: ICPC2P:T90006
database_cross_reference: ICPC2P:T90008
database_cross_reference: LNC:LA10551-2
database_cross_reference: LNC:LP36797-6
database_cross_reference: LNC:MTHU020217
database_cross_reference: MDR:10012608
database_cross_reference: MDR:10012609
database_cross_reference: MDR:10021211
database_cross_reference: MDR:10022482
database_cross_reference: MDR:10022497
database_cross_reference: MDR:10023253
database_cross_reference: MDR:10023392
database_cross_reference: MDR:10045228
database_cross_reference: MDR:10067584
database_cross_reference: MEDCIN:30481
database_cross_reference: MEDLINEPLUS:1339
database_cross_reference: MSH:D003922
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2986
database_cross_reference: NCI_NICHD:C2986
database_cross_reference: NDFRT:N0000000952
database_cross_reference: OMIM:222100
database_cross_reference: OMIM:612227
database_cross_reference: OMIM:MTHU006777
database_cross_reference: OMIM:MTHU007813
database_cross_reference: OMIM:MTHU012236
database_cross_reference: OMIM:MTHU013561
database_cross_reference: OMIM:MTHU023582
database_cross_reference: OMIM:MTHU047431
database_cross_reference: RCD:X40J4
database_cross_reference: SNM:D-2387
database_cross_reference: SNM:D-241X
database_cross_reference: SNMI:DB-61010
database_cross_reference: SNOMEDCT_US:154673001
database_cross_reference: SNOMEDCT_US:190322003
database_cross_reference: SNOMEDCT_US:190362004
database_cross_reference: SNOMEDCT_US:267469001
database_cross_reference: SNOMEDCT_US:46635009

Type II diabetes mellitus
type: Class
subclass of: Diabetes mellitus
Definition: A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia.
MCID: MC00003798
PMOID: PMO:00006370
Subclass_of: Diabetes mellitus
Synonym: -- Diabetes Type 2
Synonym: ADULT ONSET DIABETES MELLITUS
Synonym: AODM
Synonym: Adult Onset Diabetes
Synonym: Adult-Onset Diabetes
Synonym: Adult-Onset Diabetes Mellitus
Synonym: DIABETES MELLITUS (ADULT ONSET)
Synonym: DIABETES MELLITUS NON INSULIN DEPENDENT
Synonym: DIABETES MELLITUS NOS LATE ONSET
Synonym: DIABETES MELLITUS TYPE 02
Tree Number: T3.12.13.5
database_cross_reference: BI:BI00333
database_cross_reference: BI:BI00336
database_cross_reference: BI:BI00339
database_cross_reference: BI:BI00364
database_cross_reference: CCPSS:0045504
database_cross_reference: CCPSS:0058620
database_cross_reference: CHV:0000003837
database_cross_reference: COSTAR:U000225
database_cross_reference: CSP:0862-7250
database_cross_reference: DO:DOID:9352
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000472
database_cross_reference: HPO:HP:0005978
database_cross_reference: ICD10:E11
database_cross_reference: ICD10AM:E11
database_cross_reference: ICD10CM:E11
database_cross_reference: ICPC2EENG:T90
database_cross_reference: ICPC2P:T90005
database_cross_reference: ICPC2P:T90007
database_cross_reference: ICPC2P:T90009
database_cross_reference: LCH_NW:sh85092226
database_cross_reference: LNC:LA10552-0
database_cross_reference: MDR:10012611
database_cross_reference: MDR:10012612
database_cross_reference: MDR:10012613
database_cross_reference: MDR:10026947
database_cross_reference: MDR:10029402
database_cross_reference: MDR:10029505
database_cross_reference: MDR:10045242
database_cross_reference: MDR:10067585
database_cross_reference: MEDCIN:30480
database_cross_reference: MEDLINEPLUS:5930
database_cross_reference: MSH:D003924
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26747
database_cross_reference: NCI_NICHD:C26747
database_cross_reference: NDFRT:N0000000954
database_cross_reference: OMIM:125853
database_cross_reference: OMIM:138033
database_cross_reference: OMIM:138160
database_cross_reference: OMIM:138430
database_cross_reference: OMIM:147545
database_cross_reference: OMIM:147670
database_cross_reference: OMIM:164731
database_cross_reference: OMIM:167413
database_cross_reference: OMIM:189907
database_cross_reference: OMIM:600281
database_cross_reference: OMIM:600509
database_cross_reference: OMIM:601724
database_cross_reference: OMIM:604641
database_cross_reference: OMIM:MTHU006778
database_cross_reference: OMIM:MTHU014118
database_cross_reference: OMIM:MTHU023629
database_cross_reference: OMIM:MTHU028982
database_cross_reference: OMIM:MTHU047504
database_cross_reference: OMIM:MTHU051483
database_cross_reference: OMIM:MTHU055395
database_cross_reference: RCD:X40J5
database_cross_reference: SNM:D-2386
database_cross_reference: SNM:D-241Y
database_cross_reference: SNMI:DB-61030
database_cross_reference: SNOMEDCT_US:154672006
database_cross_reference: SNOMEDCT_US:190323008

Neoplasm of the endocrine system
type: Class
subclass of: Abnormality of the endocrine system
Definition: A tumor (abnormal growth of tissue) of the endocrine system.
MCID: MC00004442
PMOID: PMO:00006372
Subclass_of: Abnormality of the endocrine system
Synonym: ENDOCRINE GLAND NEOPL
Synonym: ENDOCRINE NEOPLASIA
Synonym: Endocrine Gland Neoplasm
Synonym: Endocrine Gland Neoplasms
Synonym: Endocrine Gland Neoplasms [Disease/Finding]
Synonym: Endocrine Neoplasm
Synonym: Endocrine Neoplasms
Synonym: Endocrine System Neoplasm
Synonym: Endocrine System Tumor
Synonym: Endocrine Tumor
Tree Number: T3.12.14
database_cross_reference: AOD:0000023101
database_cross_reference: AOD:0000023102
database_cross_reference: CCPSS:0035534
database_cross_reference: CHV:0000004449
database_cross_reference: CHV:0000047500
database_cross_reference: CSP:2009-5861
database_cross_reference: DO:DOID:170
database_cross_reference: HPO:HP:0100568
database_cross_reference: ICPC2P:T73005
database_cross_reference: LCH_NW:sh87001844
database_cross_reference: MDR:10014709
database_cross_reference: MDR:10061121
database_cross_reference: MEDCIN:90717
database_cross_reference: MSH:D004701
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3010
database_cross_reference: NDFRT:N0000001100
database_cross_reference: PSY:17340
database_cross_reference: RCD:X78cM
database_cross_reference: RCDAE:X78cM
database_cross_reference: SNOMEDCT_US:127015005
database_cross_reference: SNOMEDCT_US:387922007
database_cross_reference: SNOMEDCT_US:387927001

APUdoma
type: Class
subclass of: Neoplasm of the endocrine system
Definition: An endocrine tumor arising from an APUD cell.
MCID: MC00001189
PMOID: PMO:00006373
Subclass_of: Neoplasm of the endocrine system
Synonym: APUDoma
Synonym: APUDoma NOS
Synonym: Apudoma
Synonym: Apudoma (diagnosis)
Synonym: Apudoma (disorder)
Synonym: Apudoma (morphologic abnormality)
Synonym: Apudoma [Disease/Finding]
Synonym: Apudomas
Synonym: Neoplasm of Diffuse Neuroendocrine System
Synonym: Neoplasm of the Diffuse Neuroendocrine System
Tree Number: T3.12.14.1
database_cross_reference: CHV:0000001404
database_cross_reference: HPO:HP:0040192
database_cross_reference: ICD10AM:M8248/1
database_cross_reference: MDR:10003069
database_cross_reference: MDR:10003070
database_cross_reference: MEDCIN:355431
database_cross_reference: MSH:D001079
database_cross_reference: NCI:C2879
database_cross_reference: NDFRT:N0000000459
database_cross_reference: RCD:BB5y3
database_cross_reference: RCD:X77nZ
database_cross_reference: RCDSY:BB5y3
database_cross_reference: SNMI:M-82481
database_cross_reference: SNOMEDCT_US:253008000
database_cross_reference: SNOMEDCT_US:74926005

Neoplasm of the parathyroid gland
type: Class
subclass of: Neoplasm of the endocrine system
Definition: A tumor (abnormal growth of tissue) of the parathyroid gland.
MCID: MC00009734
PMOID: PMO:00006374
Subclass_of: Neoplasm of the endocrine system
Synonym: NEOPL PARATHYROID
Synonym: Neoplasm of Parathyroid
Synonym: Neoplasm of Parathyroid Gland
Synonym: Neoplasm of parathyroid gland
Synonym: Neoplasm of parathyroid gland (disorder)
Synonym: Neoplasm of the Parathyroid
Synonym: Neoplasm of the Parathyroid Gland
Synonym: Neoplasm, Parathyroid
Synonym: Neoplasms, Parathyroid
Synonym: PARATHYROID NEOPL
Tree Number: T3.12.14.2
database_cross_reference: CHV:0000009303
database_cross_reference: CSP:2009-6398
database_cross_reference: DO:DOID:1540
database_cross_reference: HPO:HP:0100733
database_cross_reference: LCH_NW:sh85097937
database_cross_reference: MDR:10033962
database_cross_reference: MDR:10033963
database_cross_reference: MDR:10033966
database_cross_reference: MEDCIN:31622
database_cross_reference: MSH:D010282
database_cross_reference: NCI:C3313
database_cross_reference: NDFRT:N0000002322
database_cross_reference: RCD:X40KV
database_cross_reference: RCDAE:X40KV
database_cross_reference: SNOMEDCT_US:127020005

Neoplasm of the pituitary gland
type: Class
subclass of: Neoplasm of the endocrine system
MCID: MC00010264
PMOID: PMO:00006377
Subclass_of: Neoplasm of the endocrine system
Synonym: Neoplasm of Pituitary
Synonym: Neoplasm of Pituitary Gland
Synonym: Neoplasm of pituitary gland
Synonym: Neoplasm of pituitary gland (disorder)
Synonym: Neoplasm of the Pituitary
Synonym: Neoplasm of the Pituitary Gland
Synonym: Neoplasm, Pituitary
Synonym: Neoplasms, Pituitary
Synonym: PITUITARY NEOPL
Synonym: PITUITARY NEOPLASM
Tree Number: T3.12.14.3
database_cross_reference: CCPSS:0023924
database_cross_reference: CHV:0000009767
database_cross_reference: COSTAR:U000534
database_cross_reference: CSP:2006-7421
database_cross_reference: DO:DOID:1785
database_cross_reference: DXP:U003156
database_cross_reference: HPO:HP:0040277
database_cross_reference: ICPC2P:T73003
database_cross_reference: LCH_NW:sh85102525
database_cross_reference: MDR:10035086
database_cross_reference: MDR:10035097
database_cross_reference: MDR:10035098
database_cross_reference: MDR:10035102
database_cross_reference: MDR:10035104
database_cross_reference: MDR:10035107
database_cross_reference: MEDCIN:30502
database_cross_reference: MEDLINEPLUS:5328
database_cross_reference: MSH:D010911
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3330
database_cross_reference: NCI_NCI-GLOSS:CDR0000446420
database_cross_reference: NDFRT:N0000002408
database_cross_reference: PDQ:CDR0000038812
database_cross_reference: RCD:X78a9
database_cross_reference: RCDAE:X78a9
database_cross_reference: SNOMEDCT_US:127024001

Neuroendocrine neoplasm
type: Class
subclass of: Neoplasm of the endocrine system
MCID: MC00067585
PMOID: PMO:00006378
Subclass_of: Neoplasm of the endocrine system
Synonym: NEUROENDOCRINE TUMORS
Synonym: Neuroendocrine Neoplasm
Synonym: Neuroendocrine Tumor
Synonym: Neuroendocrine Tumors
Synonym: Neuroendocrine Tumors [Disease/Finding]
Synonym: Neuroendocrine neoplasia
Synonym: Neuroendocrine neoplasm (morphologic abnormality)
Synonym: Neuroendocrine tumor
Synonym: Neuroendocrine tumor (disorder)
Synonym: Neuroendocrine tumor NOS
Tree Number: T3.12.14.4
database_cross_reference: CHV:0000021067
database_cross_reference: CHV:0000056678
database_cross_reference: DO:DOID:169
database_cross_reference: HPO:HP:0100634
database_cross_reference: ICD10CM:D3A.8
database_cross_reference: ICD9CM:209
database_cross_reference: ICD9CM:209-209.99
database_cross_reference: LCH_NW:sh94005134
database_cross_reference: MDR:10052399
database_cross_reference: MDR:10062476
database_cross_reference: MEDCIN:352608
database_cross_reference: MSH:D018358
database_cross_reference: MTHICD9:209.60
database_cross_reference: NCI:C3809
database_cross_reference: NCI_NCI-GLOSS:CDR0000044904
database_cross_reference: NCI_NICHD:C3809
database_cross_reference: NDFRT:N0000003804
database_cross_reference: RCD:X78dr
database_cross_reference: RCDAE:X78dr
database_cross_reference: SNOMEDCT_US:128928004
database_cross_reference: SNOMEDCT_US:255046005

Puberty and gonadal disorders
type: Class
subclass of: Abnormality of the endocrine system
MCID: MC01002357
PMOID: PMO:00006395
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.15
database_cross_reference: HPO:HP:0008373

Abnormal serum testosterone level
type: Class
subclass of: Puberty and gonadal disorders
Definition: An anomalous concentration of testosterone in the blood.
MCID: MC01396135
PMOID: PMO:00006396
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.1
database_cross_reference: HPO:HP:0030087

Absence of pubertal development
type: Class
subclass of: Puberty and gonadal disorders
MCID: MC01396458
PMOID: PMO:00006397
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.2
database_cross_reference: HPO:HP:0008197

Absence of secondary sex characteristics
type: Class
subclass of: Puberty and gonadal disorders
Definition: No secondary sexual characteristics are present at puberty.
MCID: MC01396460
PMOID: PMO:00006399
Subclass_of: Puberty and gonadal disorders
Synonym: No secondary sexual characteristics at puberty
Tree Number: T3.12.15.3
database_cross_reference: HPO:HP:0008187

Adrenogenital syndrome
type: Class
subclass of: Puberty and gonadal disorders
Definition: Adrenogenital syndrome is also known as congenital adrenal hyperplasia, which results from disorders of steroid hormone production in the adrenal glands leading to a deficiency of cortisol. The pituitary gland reacts by increased secretion of corticotropin, which in turn causes the adrenal glands to overproduce certain intermediary hormones which have testosterone-like effects.
MCID: MC00000422
PMOID: PMO:00006400
Subclass_of: Puberty and gonadal disorders
Synonym: ADRENAL HYPERPLASIA CONGEN
Synonym: ADRENAL HYPERPLASIA CONGENITAL
Synonym: ADRENAL HYPERPLASIA, CONGENITAL
Synonym: Adrenal Hyperplasia
Synonym: Adrenal Hyperplasia, Congenital
Synonym: Adrenal Hyperplasia, Congenital [Disease/Finding]
Synonym: Adrenal Hyperplasias, Congenital
Synonym: Adrenal hyperplasia syndrome, congenital
Synonym: Adrenogenital Disorder
Synonym: Adrenogenital Syndrome
Tree Number: T3.12.15.4
database_cross_reference: CCPSS:0043598
database_cross_reference: CHV:0000000769
database_cross_reference: CSP:0060-3730
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0008258
database_cross_reference: ICD10CM:E25.0
database_cross_reference: LNC:LP56767-4
database_cross_reference: LNC:MTHU021596
database_cross_reference: MDR:10010323
database_cross_reference: MEDCIN:30433
database_cross_reference: MEDLINEPLUS:128
database_cross_reference: MSH:D000312
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:255.2
database_cross_reference: NCI:C34360
database_cross_reference: NCI_NICHD:C34360
database_cross_reference: NDFRT:N0000000328
database_cross_reference: OMIM:MTHU014663
database_cross_reference: RCD:X40MT
database_cross_reference: SNM:D-2306
database_cross_reference: SNMI:D6-80100
database_cross_reference: SNOMEDCT_US:190511001
database_cross_reference: SNOMEDCT_US:237751000
database_cross_reference: SNOMEDCT_US:27037004

Androgen insufficiency
type: Class
subclass of: Puberty and gonadal disorders
Definition: Insufficient amount of androgenic activity.
MCID: MC00120422
PMOID: PMO:00006401
Subclass_of: Puberty and gonadal disorders
Synonym: ANDROGEN DEFICIENCY
Synonym: Androgen deficiency
Synonym: Androgen deficiency, NOS
Synonym: Defect of testicular androgen synthesis
Synonym: Defect testicul androgen synth
Synonym: Defective biosynthesis of testicular androgen
Synonym: Defective biosynthesis of testicular androgen NOS
Synonym: Defective biosynthesis of testicular androgen, NOS
Synonym: Deficiency of testosterone biosynthesis
Synonym: Deficiency of testosterone biosynthesis (disorder)
Tree Number: T3.12.15.5
database_cross_reference: CHV:0000030771
database_cross_reference: CST:ENDO DIS
database_cross_reference: HPO:HP:0008226
database_cross_reference: ICD10CM:E29.1
database_cross_reference: MDR:10002261
database_cross_reference: MDR:10066867
database_cross_reference: MTHICD9:257.2
database_cross_reference: NCI:C102987
database_cross_reference: NCI_NICHD:C102987
database_cross_reference: RCD:X40Nl
database_cross_reference: SNMI:DB-30700
database_cross_reference: SNOMEDCT_US:38825009
database_cross_reference: SNOMEDCT_VET:282211000009103

Delayed puberty
type: Class
subclass of: Puberty and gonadal disorders
Definition: Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.
MCID: MC00010895
PMOID: PMO:00006402
Subclass_of: Puberty and gonadal disorders
Synonym: Constitutional Growth Delay
Synonym: DELAYED PUBERTY
Synonym: Delay in sexual development AND/OR puberty
Synonym: Delay in sexual development AND/OR puberty (disorder)
Synonym: Delay in sexual development AND/OR puberty (finding)
Synonym: Delay in sexual development and/or puberty
Synonym: Delayed Puberty
Synonym: Delayed pubertal development
Synonym: Delayed pubertal growth
Synonym: Delayed puberty (& [NOS])
Tree Number: T3.12.15.6
database_cross_reference: CCPSS:1003377
database_cross_reference: CHV:0000010359
database_cross_reference: CSP:2586-8835
database_cross_reference: DO:DOID:5575
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U003541
database_cross_reference: HPO:HP:0000823
database_cross_reference: ICD10:E30.0
database_cross_reference: ICD10AM:E30.0
database_cross_reference: ICD10CM:E30.0
database_cross_reference: ICPC2P:T99047
database_cross_reference: MDR:10012205
database_cross_reference: MEDCIN:37614
database_cross_reference: MSH:D011628
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:259.0
database_cross_reference: NCI:C62587
database_cross_reference: NCI_CTCAE:E10308
database_cross_reference: NCI_NICHD:C62587
database_cross_reference: NDFRT:N0000002534
database_cross_reference: OMIM:MTHU036721
database_cross_reference: OMIM:MTHU037333
database_cross_reference: RCD:X40O7
database_cross_reference: SNM:F-96120
database_cross_reference: SNMI:DB-00120
database_cross_reference: SNOMEDCT_US:123526007
database_cross_reference: SNOMEDCT_US:154715005
database_cross_reference: SNOMEDCT_US:267487003
database_cross_reference: SNOMEDCT_US:39760001
database_cross_reference: SNOMEDCT_US:400003000
database_cross_reference: SNOMEDCT_VET:123526007

Early onset of sexual maturation
type: Class
subclass of: Puberty and gonadal disorders
Definition: An early onset of puberty, in this case early does not refer to precocious.
MCID: MC01397943
PMOID: PMO:00006406
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.7
database_cross_reference: HPO:HP:0100000

Leydig cell insensitivity to gonadotropin
type: Class
subclass of: Puberty and gonadal disorders
MCID: MC01399503
PMOID: PMO:00006415
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.8
database_cross_reference: HPO:HP:0002929

Menstrual irregularities
type: Class
subclass of: Puberty and gonadal disorders
MCID: MC01399744
PMOID: PMO:00006416
Subclass_of: Puberty and gonadal disorders
Synonym: Menstrual irregularity
Tree Number: T3.12.15.9
database_cross_reference: HPO:HP:0000858

Primary gonadal insufficiency
type: Class
subclass of: Puberty and gonadal disorders
MCID: MC01400546
PMOID: PMO:00006418
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.10
database_cross_reference: HPO:HP:0008193

Abnormality of the eye
type: Class
subclass of: Phenotypic Abnormality
Definition: Any abnormality of the eye, including location, spacing, and intraocular abnormalities.
MCID: MC00004895
PMOID: PMO:00006419
Subclass_of: Phenotypic Abnormality
Synonym: Abnormal eye
Synonym: Abnormalities, Eye
Synonym: Abnormality, Eye
Synonym: CONGENITAL ANOMALIES OF THE EYE AND ORBIT
Synonym: Congenital Diseases and Syndromes of Eye
Synonym: Congenital Eye Disorder
Synonym: Congenital Ophthalmologic Abnormality
Synonym: Congenital abnormality of eye
Synonym: Congenital abnormality of eye (disorder)
Synonym: Congenital anolmaly of eye
Tree Number: T3.13
database_cross_reference: CCPSS:0016777
database_cross_reference: CCPSS:0059393
database_cross_reference: CHV:0000004811
database_cross_reference: CHV:0000038687
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000466
database_cross_reference: COSTAR:U000488
database_cross_reference: CSP:0724-2798
database_cross_reference: CST:ANOMALY CONGEN SS
database_cross_reference: CST:EYE DIS
database_cross_reference: HPO:HP:0000478
database_cross_reference: ICD10:Q15.9
database_cross_reference: ICD10AM:Q15.9
database_cross_reference: ICD10CM:Q15.9
database_cross_reference: ICD9CM:743
database_cross_reference: ICD9CM:743.9
database_cross_reference: ICPC2P:F81001
database_cross_reference: LCH_NW:sh85046643
database_cross_reference: MDR:10010343
database_cross_reference: MDR:10010435
database_cross_reference: MDR:10010462
database_cross_reference: MDR:10015903
database_cross_reference: MDR:10015904
database_cross_reference: MDR:10015913
database_cross_reference: MDR:10015920
database_cross_reference: MDR:10015949
database_cross_reference: MDR:10045628
database_cross_reference: MDR:10048513
database_cross_reference: MDR:10059159
database_cross_reference: MEDCIN:211191
database_cross_reference: MSH:D005124
database_cross_reference: MTHICD9:743.9
database_cross_reference: NCI:C98887
database_cross_reference: NDFRT:N0000001179
database_cross_reference: OMIM:MTHU040178
database_cross_reference: RCD:P3...
database_cross_reference: RCD:P3z..
database_cross_reference: RCD:X77sF
database_cross_reference: SNM:D-X250
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-A0000
database_cross_reference: SNOMEDCT_US:156897005
database_cross_reference: SNOMEDCT_US:156902006
database_cross_reference: SNOMEDCT_US:19416009
database_cross_reference: SNOMEDCT_US:204222005
database_cross_reference: SNOMEDCT_US:231789000
database_cross_reference: SNOMEDCT_US:253210009
database_cross_reference: SNOMEDCT_US:268310007

Abnormal eye morphology
type: Class
subclass of: Abnormality of the eye
Definition: A structural anomaly of the globe of the eye, or bulbus oculi.
MCID: MC01001119
PMOID: PMO:00006420
Subclass_of: Abnormality of the eye
Synonym: Abnormally shaped eye
Tree Number: T3.13.1
database_cross_reference: HPO:HP:0012372

Abnormal anterior segment morphology
type: Class
subclass of: Abnormal eye morphology
Definition: An abnormality of the anterior segment of the eyeball (which comprises the structures in front of the vitreous humour: the cornea, iris, ciliary body, and lens).
PMOID: PMO:00006421
Subclass_of: Abnormal eye morphology
Tree Number: T3.13.1.1

Abnormal morphology of the posterior segment of the globe
type: Class
subclass of: Abnormal eye morphology
PMOID: PMO:00006591
Subclass_of: Abnormal eye morphology
Tree Number: T3.13.1.2

Abnormal sclera morphology
type: Class
subclass of: Abnormal eye morphology
Definition: An abnormality of the sclera.
MCID: MC01396117
PMOID: PMO:00006909
Subclass_of: Abnormal eye morphology
Synonym: Abnormality of the sclera
Tree Number: T3.13.1.3
database_cross_reference: HPO:HP:0000591

Abnormal uvea morphology
type: Class
subclass of: Abnormal eye morphology
Definition: An abnormality of the uvea, the vascular layer of the eyeball.
PMOID: PMO:00006920
Subclass_of: Abnormal eye morphology
Tree Number: T3.13.1.4

Abnormality of globe location
type: Class
subclass of: Abnormal eye morphology
Definition: An abnormality in the placement of the ocular globe (eyeball).
MCID: MC01000472
PMOID: PMO:00006953
Subclass_of: Abnormal eye morphology
Synonym: Abnormality of eyeball location
Synonym: Abnormality of eyeball position
Synonym: Abnormality of globe position
Tree Number: T3.13.1.5
database_cross_reference: HPO:HP:0100886

Abnormality of globe size
type: Class
subclass of: Abnormal eye morphology
Definition: An abnormality in the size of the ocular globe (eyeball).
MCID: MC01000471
PMOID: PMO:00006961
Subclass_of: Abnormal eye morphology
Synonym: Abnormality of eyeball size
Tree Number: T3.13.1.6
database_cross_reference: HPO:HP:0100887

Abnormality of the vasculature of the eye
type: Class
subclass of: Abnormal eye morphology
MCID: MC01002377
PMOID: PMO:00006965
Subclass_of: Abnormal eye morphology
Synonym: Abnormality of eye blood vessels
Tree Number: T3.13.1.7
database_cross_reference: HPO:HP:0008047

Aplasia/Hypoplasia affecting the eye
type: Class
subclass of: Abnormal eye morphology
MCID: MC01396802
PMOID: PMO:00006974
Subclass_of: Abnormal eye morphology
Synonym: Absent/small eye
Synonym: Absent/underdeveloped eye
Tree Number: T3.13.1.8
database_cross_reference: HPO:HP:0008056

Coloboma
type: Class
subclass of: Abnormal eye morphology
Definition: A developmental defect characterized by a cleft of some portion of the eye or ocular adnexa.
MCID: MC00003100
PMOID: PMO:00006991
Subclass_of: Abnormal eye morphology
Synonym: COI
Synonym: COI - Coloboma iris/chor/retin
Synonym: COI - Coloboma of iris, choroid and retina
Synonym: COLOBOMA
Synonym: COLOBOMA OF IRIS, CHOROID, AND RETINA
Synonym: COLOBOMA, OCULAR
Synonym: COLOBOMA, OCULAR, AUTOSOMAL DOMINANT
Synonym: COLOBOMA, UVEORETINAL
Synonym: Coloboma NOS
Synonym: Coloboma Of Iris, Choroid, And Retina
Tree Number: T3.13.1.9
database_cross_reference: CCPSS:1017416
database_cross_reference: CHV:0000003167
database_cross_reference: DO:DOID:12270
database_cross_reference: HPO:HP:0000589
database_cross_reference: ICD10CM:Q13.0
database_cross_reference: MDR:10009934
database_cross_reference: MDR:10009937
database_cross_reference: MEDCIN:11534
database_cross_reference: MEDCIN:211196
database_cross_reference: MEDCIN:360537
database_cross_reference: MSH:D003103
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98877
database_cross_reference: NDFRT:N0000000810
database_cross_reference: OMIM:120200
database_cross_reference: OMIM:606522
database_cross_reference: OMIM:606608
database_cross_reference: OMIM:MTHU003777
database_cross_reference: OMIM:MTHU012405
database_cross_reference: OMIM:MTHU019860
database_cross_reference: OMIM:MTHU026213
database_cross_reference: OMIM:MTHU026549
database_cross_reference: OMIM:MTHU042339
database_cross_reference: RCD:X77st
database_cross_reference: SNM:M-20190
database_cross_reference: SNMI:D4-A0006
database_cross_reference: SNMI:DA-70340
database_cross_reference: SNOMEDCT_US:92828000
database_cross_reference: SNOMEDCT_US:93390002

Phthisis bulbi
type: Class
subclass of: Abnormal eye morphology
Definition: Atrophy of the eyeball with blindness and decreased intraocular pressure due to end-stage intraocular disease.
MCID: MC00094616
PMOID: PMO:00007000
Subclass_of: Abnormal eye morphology
Synonym: Atrophia bulbi
Synonym: Atrophy of eye
Synonym: Atrophy of globe
Synonym: Atrophy of globe, unspecified eye
Synonym: Eyeball atrophic
Synonym: Globe of eye shrunken
Synonym: Globe of eye shrunken (disorder)
Synonym: Globe of eye shrunken (finding)
Synonym: PHTHISIS BULBI
Synonym: Phthisical eye
Tree Number: T3.13.1.10
database_cross_reference: CCPSS:0023942
database_cross_reference: CHV:0000026570
database_cross_reference: HPO:HP:0000667
database_cross_reference: ICD10CM:H44.52
database_cross_reference: ICD10CM:H44.529
database_cross_reference: MDR:10065684
database_cross_reference: MDR:10067488
database_cross_reference: MEDCIN:273872
database_cross_reference: MEDCIN:36435
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:360.41
database_cross_reference: OMIM:MTHU037383
database_cross_reference: RCD:F4041
database_cross_reference: RCD:X75hP
database_cross_reference: SNM:M-58500
database_cross_reference: SNMI:DA-70412
database_cross_reference: SNMI:DA-70414
database_cross_reference: SNOMEDCT_US:111510002
database_cross_reference: SNOMEDCT_US:246922000
database_cross_reference: SNOMEDCT_US:4229009

Spontaneous rupture of the globe
type: Class
subclass of: Abnormal eye morphology
Definition: Rupture of the eyeball not due to trauma.
MCID: MC01001580
PMOID: PMO:00007001
Subclass_of: Abnormal eye morphology
Tree Number: T3.13.1.11
database_cross_reference: HPO:HP:0010727

Abnormal eye physiology
type: Class
subclass of: Abnormality of the eye
Definition: A functional anomaly of the eye.
MCID: MC01001118
PMOID: PMO:00007002
Subclass_of: Abnormality of the eye
Tree Number: T3.13.2
database_cross_reference: HPO:HP:0012373

Abnormal extraocular muscle physiology
type: Class
subclass of: Abnormal eye physiology
Definition: A functional anomaly of the muscles of the eye.
MCID: MC01395883
PMOID: PMO:00007003
Subclass_of: Abnormal eye physiology
Tree Number: T3.13.2.1
database_cross_reference: HPO:HP:0025590

Abnormal intraocular pressure
type: Class
subclass of: Abnormal eye physiology
Definition: An anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye.
MCID: MC01395943
PMOID: PMO:00007038
Subclass_of: Abnormal eye physiology
Synonym: Abnormal eye pressure
Tree Number: T3.13.2.2
database_cross_reference: HPO:HP:0012632

Abnormal pupillary function
type: Class
subclass of: Abnormal eye physiology
Definition: A functional abnormality of the pupil.
MCID: MC00010924
PMOID: PMO:00007041
Subclass_of: Abnormal eye physiology
Synonym: Disorder of pupil
Synonym: PUPIL DIS
Synonym: PUPILLARY DIS
Synonym: PUPILLARY DISORDER
Synonym: Pupil Disorder
Synonym: Pupil Disorders
Synonym: Pupil Disorders [Disease/Finding]
Synonym: Pupil disorders
Synonym: Pupillary Disorder
Synonym: Pupillary Disorders
Tree Number: T3.13.2.3
database_cross_reference: CST:PUPIL DIS
database_cross_reference: DO:DOID:238
database_cross_reference: HPO:HP:0007686
database_cross_reference: MDR:10037514
database_cross_reference: MDR:10037521
database_cross_reference: MDR:10037522
database_cross_reference: MSH:D011681
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002551
database_cross_reference: SNMI:DA-72710
database_cross_reference: SNOMEDCT_US:68633000

Abnormal visual accommodation
type: Class
subclass of: Abnormal eye physiology
Definition: An anomaly in the process of visual accommodation, which is the process of adjustment of the eye to enable sharp vision of objects at different distances. Accommodation is mediated by contraction of the ciliary muscles, which alter the convexity of the lens and, consequently, its refractive power.
MCID: MC01057028
PMOID: PMO:00007049
Subclass_of: Abnormal eye physiology
Tree Number: T3.13.2.4
database_cross_reference: HPO:HP:0030800

Abnormal visual electrophysiology
type: Class
subclass of: Abnormal eye physiology
MCID: MC01396219
PMOID: PMO:00007051
Subclass_of: Abnormal eye physiology
Tree Number: T3.13.2.5
database_cross_reference: HPO:HP:0030453

Abnormality of eye movement
type: Class
subclass of: Abnormal eye physiology
Definition: An abnormality in voluntary or involuntary eye movements or their control.
MCID: MC01396281
PMOID: PMO:00007103
Subclass_of: Abnormal eye physiology
Synonym: Abnormal extraocular movement
Synonym: Abnormal extraocular movements
Synonym: Abnormal eye motility
Synonym: Abnormal eye movement
Synonym: Abnormal eye movements
Synonym: Abnormal motility of the globe of the eye
Synonym: Abnormal movement of the globe of the eye
Synonym: Abnormal ocular movements
Synonym: Eye movement abnormalities
Synonym: Eye movement issue
Tree Number: T3.13.2.6
database_cross_reference: HPO:HP:0000496

Abnormality of refraction
type: Class
subclass of: Abnormal eye physiology
Definition: An abnormality in the process of focusing of light by the eye in order to produce a sharp image on the retina.
MCID: MC01003102
PMOID: PMO:00007261
Subclass_of: Abnormal eye physiology
Tree Number: T3.13.2.7
database_cross_reference: HPO:HP:0000539

Abnormality of vision
type: Class
subclass of: Abnormal eye physiology
Definition: Abnormality of eyesight (visual perception).
MCID: MC01003105
PMOID: PMO:00007284
Subclass_of: Abnormal eye physiology
Synonym: Abnormality of sight
Tree Number: T3.13.2.8
database_cross_reference: HPO:HP:0000504

Asthenopia
type: Class
subclass of: Abnormal eye physiology
Definition: Eye strain, i.e., a feeling of fatigue or discomfort of the eyes related to 'overuse' of the eyes in activities such as reading or working at the computer and often accompanied by lacrimation or headache.
MCID: MC00001328
PMOID: PMO:00007437
Subclass_of: Abnormal eye physiology
Synonym: ASTHENOPIA
Synonym: ASTHENOPIA, ACCOMMODATIVE
Synonym: Accommodative asthenopia
Synonym: Accommodative asthenopia (finding)
Synonym: Accommodative strain
Synonym: Accommodative strain (disorder)
Synonym: Asthenopia [Disease/Finding]
Synonym: Eye Fatigue
Synonym: Eye Strain
Synonym: Eye strain
Tree Number: T3.13.2.9
database_cross_reference: CHV:0000001540
database_cross_reference: COSTAR:079
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10141
database_cross_reference: DXP:U000272
database_cross_reference: HPO:HP:0031590
database_cross_reference: ICD10CM:H53.14
database_cross_reference: ICPC2P:F05025
database_cross_reference: ICPC2P:F29001
database_cross_reference: ICPC2P:F29004
database_cross_reference: LCH:U000404
database_cross_reference: LCH:U005181
database_cross_reference: LCH_NW:sh85008857
database_cross_reference: MDR:10003552
database_cross_reference: MDR:10015969
database_cross_reference: MDR:10043887
database_cross_reference: MDR:10043888
database_cross_reference: MDR:10049755
database_cross_reference: MEDCIN:134
database_cross_reference: MEDCIN:2057
database_cross_reference: MEDCIN:30757
database_cross_reference: MSH:D001248
database_cross_reference: MTHICD9:368.13
database_cross_reference: NDFRT:N0000000497
database_cross_reference: RCD:F4815
database_cross_reference: RCD:F4816
database_cross_reference: SNM:F-X0810
database_cross_reference: SNM:F-X2780
database_cross_reference: SNMI:F-F0654
database_cross_reference: SNMI:F-F1764
database_cross_reference: SNOMEDCT_US:193645002
database_cross_reference: SNOMEDCT_US:46640001
database_cross_reference: SNOMEDCT_US:70323002

Cone dysfunction syndrome
type: Class
subclass of: Abnormal eye physiology
Definition: Retinal phenotype characterised by cone photoreceptor dysfunction and preserved rod system. The abnormality is typically stationary or very slowly progressive and findings may include reduced central vision, colour vision abnormalities, nystagmus and photophobia.
MCID: MC00171287
PMOID: PMO:00007438
Subclass_of: Abnormal eye physiology
Synonym: Cone dysfunction
Tree Number: T3.13.2.10
database_cross_reference: HPO:HP:0030637
database_cross_reference: SNM:D-X017

Glaucoma
type: Class
subclass of: Abnormal eye physiology
Definition: Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure.
MCID: MC00005620
PMOID: PMO:00007439
Subclass_of: Abnormal eye physiology
Synonym: A-730-733 GLAUCOMAS
Synonym: GLAUCOMA
Synonym: GLAUCOMAS
Synonym: Glaucoma (H40-H42)
Synonym: Glaucoma (disorder)
Synonym: Glaucoma NOS
Synonym: Glaucoma NOS (disorder)
Synonym: Glaucoma [Disease/Finding]
Synonym: Glaucoma syndrome
Synonym: Glaucoma, NOS
Tree Number: T3.13.2.11
database_cross_reference: AOD:0000006031
database_cross_reference: BI:BI00013
database_cross_reference: CCPSS:0043103
database_cross_reference: CHV:0000005514
database_cross_reference: COSTAR:331
database_cross_reference: CSP:1114-9010
database_cross_reference: CST:GLAUCOMA
database_cross_reference: DO:DOID:1686
database_cross_reference: DXP:U001708
database_cross_reference: HPO:HP:0000501
database_cross_reference: ICD10:H40
database_cross_reference: ICD10:H40-H42.9
database_cross_reference: ICD10:H40.9
database_cross_reference: ICD10AM:H40
database_cross_reference: ICD10AM:H40-H42.9
database_cross_reference: ICD10AM:H40.9
database_cross_reference: ICD10CM:H40
database_cross_reference: ICD10CM:H40-H42
database_cross_reference: ICD10CM:H40.9
database_cross_reference: ICD9CM:365
database_cross_reference: ICD9CM:365.9
database_cross_reference: ICPC2EENG:F93
database_cross_reference: ICPC2P:F93001
database_cross_reference: LCH:U001972
database_cross_reference: LCH_NW:sh85055227
database_cross_reference: LNC:LA16302-4
database_cross_reference: LNC:MTHU020819
database_cross_reference: MDR:10018304
database_cross_reference: MDR:10018326
database_cross_reference: MDR:10018332
database_cross_reference: MDR:10045894
database_cross_reference: MEDCIN:30746
database_cross_reference: MEDLINEPLUS:42
database_cross_reference: MSH:D005901
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26782
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_CTCAE:E10392
database_cross_reference: NCI_FDA:1875
database_cross_reference: NCI_NCI-GLOSS:CDR0000534224
database_cross_reference: NCI_NICHD:C26782
database_cross_reference: NDFRT:N0000001345
database_cross_reference: OMIM:MTHU004639
database_cross_reference: PSY:21090
database_cross_reference: RCD:F45..
database_cross_reference: RCD:F45z.
database_cross_reference: SNM:D-X300
database_cross_reference: SNM:U000025
database_cross_reference: SNMI:DA-73000
database_cross_reference: SNOMEDCT_US:155120009
database_cross_reference: SNOMEDCT_US:193569008
database_cross_reference: SNOMEDCT_US:194631001
database_cross_reference: SNOMEDCT_US:23986001

Inflammatory abnormality of the eye
type: Class
subclass of: Abnormal eye physiology
Definition: Inflammation of the eye, parts of the eye or the periorbital region.
MCID: MC00999736
PMOID: PMO:00007445
Subclass_of: Abnormal eye physiology
Synonym: Ocular inflammation
Tree Number: T3.13.2.12
database_cross_reference: HPO:HP:0100533

Lacrimation abnormality
type: Class
subclass of: Abnormal eye physiology
Definition: Abnormality of tear production.
MCID: MC01000350
PMOID: PMO:00007466
Subclass_of: Abnormal eye physiology
Synonym: Abnormality of tear production
Tree Number: T3.13.2.13
database_cross_reference: HPO:HP:0000632

Ptosis
type: Class
subclass of: Abnormal eye physiology
Definition: The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective).
MCID: MC00001811
PMOID: PMO:00007476
Subclass_of: Abnormal eye physiology
Synonym: BLEPHAROPTOSIS
Synonym: Blepharoptoses
Synonym: Blepharoptosis
Synonym: Blepharoptosis [Disease/Finding]
Synonym: Drooping eyelid
Synonym: Drooping upper eyelid
Synonym: Drooping;eyelid
Synonym: Droopy eyelid
Synonym: Droopy eyelids
Synonym: Eyelid Ptoses
Tree Number: T3.13.2.14
database_cross_reference: CCPSS:0033071
database_cross_reference: CHV:0000001973
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:PTOSIS
database_cross_reference: DO:DOID:0060260
database_cross_reference: HPO:HP:0000508
database_cross_reference: ICD10:H02.4
database_cross_reference: ICD10AM:H02.4
database_cross_reference: ICD10CM:H02.4
database_cross_reference: ICD10CM:H02.40
database_cross_reference: ICD10CM:H02.409
database_cross_reference: ICD9CM:374.3
database_cross_reference: ICD9CM:374.30
database_cross_reference: ICPC2P:F16002
database_cross_reference: ICPC2P:F16005
database_cross_reference: LCH:U000606
database_cross_reference: LCH_NW:sh85014843
database_cross_reference: MDR:10005157
database_cross_reference: MDR:10015995
database_cross_reference: MDR:10037273
database_cross_reference: MDR:10037274
database_cross_reference: MEDCIN:2042
database_cross_reference: MEDCIN:36768
database_cross_reference: MEDCIN:6436
database_cross_reference: MEDLINEPLUS:5404
database_cross_reference: MSH:D001763
database_cross_reference: MTH:U001745
database_cross_reference: NCI:C27298
database_cross_reference: NCI_FDA:2620
database_cross_reference: NCI_NCI-GLOSS:CDR0000044081
database_cross_reference: NCI_NICHD:C27298
database_cross_reference: NDFRT:N0000000570
database_cross_reference: OMIM:MTHU000509
database_cross_reference: OMIM:MTHU000860
database_cross_reference: OMIM:MTHU038613
database_cross_reference: OMIM:MTHU039308
database_cross_reference: RCD:F4E30
database_cross_reference: RCD:F4E3z
database_cross_reference: RCD:XM050
database_cross_reference: SNM:M-31050
database_cross_reference: SNMI:DA-76330
database_cross_reference: SNOMEDCT_US:11934000
database_cross_reference: SNOMEDCT_US:155179008
database_cross_reference: SNOMEDCT_US:193942002
database_cross_reference: SNOMEDCT_US:193943007
database_cross_reference: SNOMEDCT_US:193945000
database_cross_reference: SNOMEDCT_US:204197004
database_cross_reference: SNOMEDCT_VET:11934000

Staring gaze
type: Class
subclass of: Abnormal eye physiology
Definition: An abnormality in which the eyes are held permanently wide open.
MCID: MC01401306
PMOID: PMO:00007482
Subclass_of: Abnormal eye physiology
Synonym: Staring eyes
Tree Number: T3.13.2.15
database_cross_reference: HPO:HP:0025401

Abnormality of the genitourinary system
type: Class
subclass of: Phenotypic Abnormality
Definition: The presence of any abnormality of the genitourinary system.
MCID: MC00013393
PMOID: PMO:00007483
Subclass_of: Phenotypic Abnormality
Synonym: ABNORM UROGENITAL
Synonym: ANOMALY CONGENITAL UROGENITAL
Synonym: Abnormalities, Genitourinary
Synonym: Abnormalities, Urogenital
Synonym: Abnormality, Genitourinary
Synonym: Abnormality, Urogenital
Synonym: Anomaly congenital urogenital
Synonym: Congenital Abnormality of the Genitourinary System
Synonym: Congenital Genitourinary Abnormality
Synonym: Congenital Urogenital Malformations
Tree Number: T3.14
database_cross_reference: COSTAR:U000322
database_cross_reference: CST:ANOMALY CONGEN UG
database_cross_reference: DO:DOID:2038
database_cross_reference: HPO:HP:0000119
database_cross_reference: MDR:10002625
database_cross_reference: MDR:10046692
database_cross_reference: MDR:10046693
database_cross_reference: MDR:10046699
database_cross_reference: MDR:10046700
database_cross_reference: MDR:10062334
database_cross_reference: MSH:D014564
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35107
database_cross_reference: NCI_NICHD:C35107
database_cross_reference: NDFRT:N0000003083
database_cross_reference: RCD:Xa3ha
database_cross_reference: RCD:Xa3hb
database_cross_reference: SNM:M-23000
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-70100
database_cross_reference: SNOMEDCT_US:12537003
database_cross_reference: SNOMEDCT_US:156962009
database_cross_reference: SNOMEDCT_US:156981001
database_cross_reference: SNOMEDCT_US:287085006
database_cross_reference: SNOMEDCT_US:287086007

Abnormality of the genital system
type: Class
subclass of: Abnormality of the genitourinary system
Definition: An abnormality of the genital system.
MCID: MC01396381
PMOID: PMO:00007484
Subclass_of: Abnormality of the genitourinary system
Synonym: Genital abnormalities
Synonym: Genital abnormality
Synonym: Genital anomalies
Synonym: Genital defects
Tree Number: T3.14.1
database_cross_reference: HPO:HP:0000078

Abnormal reproductive system morphology
type: Class
subclass of: Abnormality of the genital system
Definition: A structural or developmental anomaly of any of the tissues involved in the genital system.
MCID: MC00999828
PMOID: PMO:00007485
Subclass_of: Abnormality of the genital system
Synonym: Abnormal genital system morphology
Tree Number: T3.14.1.1
database_cross_reference: HPO:HP:0012243

Abnormality of reproductive system physiology
type: Class
subclass of: Abnormality of the genital system
Definition: An abnormal functionality of the genital system.
MCID: MC01000369
PMOID: PMO:00007751
Subclass_of: Abnormality of the genital system
Synonym: Genital functional abnormality
Tree Number: T3.14.1.2
database_cross_reference: HPO:HP:0000080

Abnormality of the urinary system
type: Class
subclass of: Abnormality of the genitourinary system
Definition: An abnormality of the urinary system.
MCID: MC01000370
PMOID: PMO:00007795
Subclass_of: Abnormality of the genitourinary system
Synonym: Urinary tract abnormalities
Synonym: Urinary tract abnormality
Synonym: Urinary tract anomalies
Tree Number: T3.14.2
database_cross_reference: HPO:HP:0000079

Abnormality of the lower urinary tract
type: Class
subclass of: Abnormality of the urinary system
Definition: An abnormality of the lower urinary tract.
MCID: MC01001558
PMOID: PMO:00007796
Subclass_of: Abnormality of the urinary system
Tree Number: T3.14.2.1
database_cross_reference: HPO:HP:0010936

Abnormality of the upper urinary tract
type: Class
subclass of: Abnormality of the urinary system
Definition: An abnormality of the upper urinary tract.
MCID: MC01001559
PMOID: PMO:00007864
Subclass_of: Abnormality of the urinary system
Tree Number: T3.14.2.2
database_cross_reference: HPO:HP:0010935

Abnormality of the urinary system physiology
type: Class
subclass of: Abnormality of the urinary system
MCID: MC01001448
PMOID: PMO:00008065
Subclass_of: Abnormality of the urinary system
Tree Number: T3.14.2.3
database_cross_reference: HPO:HP:0011277

Urinary tract atresia
type: Class
subclass of: Abnormality of the urinary system
Definition: Congenital absence of the normal opening of a structure of the urinary tract.
MCID: MC00477720
PMOID: PMO:00008201
Subclass_of: Abnormality of the urinary system
Tree Number: T3.14.2.4
database_cross_reference: HPO:HP:0000809

Neoplasm of the genitourinary tract
type: Class
subclass of: Abnormality of the genitourinary system
Definition: A tumor (abnormal growth of tissue) of the genitourinary system.
MCID: MC00013394
PMOID: PMO:00008202
Subclass_of: Abnormality of the genitourinary system
Synonym: GENITO URINARY NEOPL
Synonym: GENITOURINARY NEOPL
Synonym: Genito-urinary Neoplasm
Synonym: Genito-urinary Neoplasms
Synonym: Genitourinary Neoplasm
Synonym: Genitourinary Neoplasms
Synonym: Genitourinary tract neoplasm
Synonym: Genitourinary tract neoplasm NOS
Synonym: Genitourinary tract tumors
Synonym: NEOPL GENITOURINARY
Tree Number: T3.14.3
database_cross_reference: CHV:0000012802
database_cross_reference: CST:NEOPL UG
database_cross_reference: HPO:HP:0007379
database_cross_reference: MDR:10018192
database_cross_reference: MDR:10029101
database_cross_reference: MDR:10046701
database_cross_reference: MDR:10046702
database_cross_reference: MDR:10046703
database_cross_reference: MDR:10061183
database_cross_reference: MSH:D014565
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003084

Benign genitourinary tract neoplasm
type: Class
subclass of: Neoplasm of the genitourinary tract
Definition: A non-malignant neoplasm of the genitourinary system.
MCID: MC00958290
PMOID: PMO:00008203
Subclass_of: Neoplasm of the genitourinary tract
Synonym: Benign genitourinary tract tumor
Synonym: Benign genitourinary tract tumors
Tree Number: T3.14.3.1
database_cross_reference: HPO:HP:0006778
database_cross_reference: MDR:10074418
database_cross_reference: OMIM:MTHU017050

Genital neoplasm
type: Class
subclass of: Neoplasm of the genitourinary tract
Definition: A tumor (abnormal growth of tissue) of the genital system.
MCID: MC00223662
PMOID: PMO:00008204
Subclass_of: Neoplasm of the genitourinary tract
Synonym: Genital tumor
Synonym: genital neoplasm
Synonym: genital neoplasms
Tree Number: T3.14.3.2
database_cross_reference: AOD:0000023081
database_cross_reference: CHV:0000043055
database_cross_reference: HPO:HP:0010787

Malignant genitourinary tract tumor
type: Class
subclass of: Neoplasm of the genitourinary tract
Definition: The presence of a malignant neoplasm of the genital system.
MCID: MC00603387
PMOID: PMO:00008224
Subclass_of: Neoplasm of the genitourinary tract
Synonym: Malignant genitourinary tract tumors
Tree Number: T3.14.3.3
database_cross_reference: HPO:HP:0006758
database_cross_reference: OMIM:MTHU017052

Urinary tract neoplasm
type: Class
subclass of: Neoplasm of the genitourinary tract
Definition: The presence of a neoplasm of the urinary system.
MCID: MC00013398
PMOID: PMO:00008225
Subclass_of: Neoplasm of the genitourinary tract
Synonym: NEOPL UROL
Synonym: Neoplasm of Urinary System
Synonym: Neoplasm of Urinary Tract
Synonym: Neoplasm of the Urinary System
Synonym: Neoplasm of the Urinary Tract
Synonym: Neoplasm of urinary system
Synonym: Neoplasm of urinary system (disorder)
Synonym: Neoplasm of urinary tract
Synonym: Neoplasm of urinary tract (disorder)
Synonym: Neoplasm of urinary tract proper
Tree Number: T3.14.3.4
database_cross_reference: AOD:0000023077
database_cross_reference: CHV:0000012807
database_cross_reference: CSP:2021-0179
database_cross_reference: DO:DOID:731
database_cross_reference: HPO:HP:0010786
database_cross_reference: ICPC2P:U79002
database_cross_reference: MDR:10046583
database_cross_reference: MDR:10061398
database_cross_reference: MSH:D014571
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3431
database_cross_reference: NDFRT:N0000003087
database_cross_reference: RCD:X78Ys
database_cross_reference: RCDAE:X78Ys
database_cross_reference: SNOMEDCT_US:126879004
database_cross_reference: SNOMEDCT_US:254913005

Urogenital fistula
type: Class
subclass of: Abnormality of the genitourinary system
Definition: The presence of a fistula affecting the genitourinary system.
MCID: MC00297656
PMOID: PMO:00008242
Subclass_of: Abnormality of the genitourinary system
Synonym: Genitourinary Fistula
Synonym: Urogenital Fistula
Synonym: Urogenital fistula NOS
Synonym: genitourinary fistula
Synonym: genitourinary fistula (diagnosis)
Tree Number: T3.14.4
database_cross_reference: HPO:HP:0100589
database_cross_reference: MDR:10046696
database_cross_reference: MDR:10046698
database_cross_reference: MEDCIN:363310
database_cross_reference: NCI:C9489

Bladder fistula
type: Class
subclass of: Urogenital fistula
Definition: The presence of a fistula connecting the urinary bladder to another organ or the skin. The fistula can involve the bowel, the vagina, or rarely, the skin.
MCID: MC00001788
PMOID: PMO:00008243
Subclass_of: Urogenital fistula
Synonym: BLADDER FISTULA
Synonym: Bladder Fistula
Synonym: Bladder fistula (disorder)
Synonym: Bladder fistula, NOS
Synonym: FISTULA, BLADDER
Synonym: Fistula - vesical
Synonym: Fistula, Urinary Bladder
Synonym: Fistula, Vesical
Synonym: Fistula, bladder NOS
Synonym: Fistulas, Urinary Bladder
Tree Number: T3.14.4.1
database_cross_reference: CHV:0000001954
database_cross_reference: DXP:U000378
database_cross_reference: DXP:U000663
database_cross_reference: HPO:HP:0004321
database_cross_reference: MDR:10047363
database_cross_reference: MDR:10051263
database_cross_reference: MEDCIN:330475
database_cross_reference: MEDCIN:96706
database_cross_reference: MSH:D001747
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:596.2
database_cross_reference: NCI:C79849
database_cross_reference: NCI_NICHD:C79849
database_cross_reference: NDFRT:N0000000562
database_cross_reference: RCD:X30OX
database_cross_reference: SNMI:D7-21500
database_cross_reference: SNOMEDCT_US:155890000
database_cross_reference: SNOMEDCT_US:266630005
database_cross_reference: SNOMEDCT_US:68666001

Perineal fistula
type: Class
subclass of: Urogenital fistula
Definition: The presence of a fistula between the bowel and the perineum.
MCID: MC00174275
PMOID: PMO:00008245
Subclass_of: Urogenital fistula
Synonym: Perineal fistula (disorder)
Synonym: fistulas perineal
Synonym: perineal fistula
Tree Number: T3.14.4.2
database_cross_reference: CHV:0000039767
database_cross_reference: HPO:HP:0004871
database_cross_reference: MDR:10056556
database_cross_reference: OMIM:MTHU013659
database_cross_reference: RCD:Xa2b8
database_cross_reference: SNOMEDCT_US:284077005

Urethral fistula
type: Class
subclass of: Urogenital fistula
Definition: The presence of an abnormal connection between the urethra and another organ or the skin.
MCID: MC00013353
PMOID: PMO:00008247
Subclass_of: Urogenital fistula
Synonym: URETHRA FISTULA
Synonym: URETHRAL FISTULA
Synonym: Urethral Fistula
Synonym: Urethral fistula (disorder)
Synonym: Urethral fistula NOS
Synonym: Urethral fistula NOS (disorder)
Synonym: Urethral fistula, NOS
Synonym: urethral fistula
Synonym: urethral fistula (diagnosis)
Tree Number: T3.14.4.3
database_cross_reference: CCPSS:0035394
database_cross_reference: CHV:0000012767
database_cross_reference: DXP:U004222
database_cross_reference: HPO:HP:0010480
database_cross_reference: ICD10:N36.0
database_cross_reference: ICD10AM:N36.0
database_cross_reference: ICD10CM:N36.0
database_cross_reference: ICD9CM:599.1
database_cross_reference: MDR:10046451
database_cross_reference: MEDCIN:330492
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78668
database_cross_reference: RCD:K191.
database_cross_reference: RCD:K191z
database_cross_reference: SNMI:D7-23510
database_cross_reference: SNOMEDCT_US:14981000
database_cross_reference: SNOMEDCT_US:197933005
database_cross_reference: SNOMEDCT_US:236696008

Abnormality of the immune system
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the immune system.
MCID: MC01000309
PMOID: PMO:00008249
Subclass_of: Phenotypic Abnormality
Synonym: Immunological abnormality
Tree Number: T3.15
database_cross_reference: HPO:HP:0002715

Abnormality of cellular immune system
type: Class
subclass of: Abnormality of the immune system
Definition: An abnormality of the morphology or counts of the cells that make up the immune system.
MCID: MC01001540
PMOID: PMO:00008250
Subclass_of: Abnormality of the immune system
Tree Number: T3.15.1
database_cross_reference: HPO:HP:0010987

Abnormal leukocyte morphology
type: Class
subclass of: Abnormality of cellular immune system
Definition: An abnormality of leukocytes.
MCID: MC01395963
PMOID: PMO:00008251
Subclass_of: Abnormality of cellular immune system
Synonym: Abnormal leukocyte function
Synonym: Abnormality of leukocytes
Tree Number: T3.15.1.1
database_cross_reference: HPO:HP:0001881

Abnormality of immune system physiology
type: Class
subclass of: Abnormality of the immune system
Definition: A functional abnormality of the immune system.
MCID: MC01001543
PMOID: PMO:00008378
Subclass_of: Abnormality of the immune system
Tree Number: T3.15.2
database_cross_reference: HPO:HP:0010978

Abnormal inflammatory response
type: Class
subclass of: Abnormality of immune system physiology
Definition: Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
MCID: MC01001055
PMOID: PMO:00008379
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.1
database_cross_reference: HPO:HP:0012647

Abnormal lymphocyte physiology
type: Class
subclass of: Abnormality of immune system physiology
Definition: Any anomaly of lymphocyte function.
MCID: MC01395983
PMOID: PMO:00008446
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.2
database_cross_reference: HPO:HP:0031409

Abnormal lymphocyte surface marker expression
type: Class
subclass of: Abnormality of immune system physiology
Definition: Abnormal amount of a protein that is normally present on the cell surface of lymphocytes.
MCID: MC01395985
PMOID: PMO:00008521
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.3
database_cross_reference: HPO:HP:0031383

Abnormal MHC II surface expression
type: Class
subclass of: Abnormality of immune system physiology
Definition: A deviation from the normal level of major histocompatibility complex class II molecules expressed at the cell surface.
MCID: MC01395999
PMOID: PMO:00008524
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.4
database_cross_reference: HPO:HP:0031389

Abnormality of humoral immunity
type: Class
subclass of: Abnormality of immune system physiology
Definition: An abnormality of the humoral immune system, which comprises antibodies produced by B cells as well as the complement system.
MCID: MC01396310
PMOID: PMO:00008527
Subclass_of: Abnormality of immune system physiology
Synonym: Defective humoral immunity
Tree Number: T3.15.2.5
database_cross_reference: HPO:HP:0005368

Abnormality of immune serum protein physiology
type: Class
subclass of: Abnormality of immune system physiology
Definition: An abnormality of the concentration or function of circulating immune proteins.
MCID: MC01001499
PMOID: PMO:00008553
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.6
database_cross_reference: HPO:HP:0011111

Autoimmunity
type: Class
subclass of: Abnormality of immune system physiology
Definition: The occurrence of an immune reaction against the organism's own cells or tissues.
MCID: MC00001392
PMOID: PMO:00008568
Subclass_of: Abnormality of immune system physiology
Synonym: AUTOIMMUNE DIS
Synonym: AUTOIMMUNE DISEASE
Synonym: AUTOIMMUNE DISORDER
Synonym: Autoimmune Disease
Synonym: Autoimmune Diseases
Synonym: Autoimmune Diseases [Disease/Finding]
Synonym: Autoimmune Disorder
Synonym: Autoimmune Disorders
Synonym: Autoimmune condition
Synonym: Autoimmune disease
Tree Number: T3.15.2.7
database_cross_reference: AOD:0000005956
database_cross_reference: AOD:0000023560
database_cross_reference: CCPSS:0022871
database_cross_reference: CHV:0000001603
database_cross_reference: CHV:0000001605
database_cross_reference: CSP:1560-5548
database_cross_reference: CSP:4003-0004
database_cross_reference: DXP:U000296
database_cross_reference: HPO:HP:0002960
database_cross_reference: ICD10CM:M30-M36
database_cross_reference: LCH:U000443
database_cross_reference: LCH_NW:sh85010076
database_cross_reference: LCH_NW:sh87006465
database_cross_reference: LNC:LP128504-0
database_cross_reference: LNC:LP130888-3
database_cross_reference: LNC:MTHU040269
database_cross_reference: LNC:MTHU040494
database_cross_reference: MDR:10003815
database_cross_reference: MDR:10003816
database_cross_reference: MDR:10061664
database_cross_reference: MEDCIN:98338
database_cross_reference: MEDLINEPLUS:154
database_cross_reference: MSH:D001327
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:279.49
database_cross_reference: NCI:C2889
database_cross_reference: NCI_CTCAE:E11258
database_cross_reference: NCI_FDA:1732
database_cross_reference: NCI_NCI-GLOSS:CDR0000045604
database_cross_reference: NCI_NICHD:C2889
database_cross_reference: NDFRT:N0000000514
database_cross_reference: OMIM:109100
database_cross_reference: OMIM:MTHU027840
database_cross_reference: OMIM:MTHU028125
database_cross_reference: OMIM:MTHU055602
database_cross_reference: PSY:04920
database_cross_reference: RCD:C394.
database_cross_reference: RCD:Xa2b1
database_cross_reference: SNM:D-4700
database_cross_reference: SNM:U000015
database_cross_reference: SNMI:DC-50020
database_cross_reference: SNOMEDCT_US:191006002
database_cross_reference: SNOMEDCT_US:85828009

Chronic infection
type: Class
subclass of: Abnormality of immune system physiology
Definition: Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.
MCID: MC00058108
PMOID: PMO:00008600
Subclass_of: Abnormality of immune system physiology
Synonym: Chronic infection (disorder)
Synonym: Chronic infectious disease
Synonym: Chronic infectious disease (disorder)
Synonym: Chronic infectious disease [Ambiguous]
Synonym: chronic disease infectious
Synonym: chronic infection
Synonym: chronic infections
Synonym: infection chronic
Tree Number: T3.15.2.8
database_cross_reference: CHV:0000016962
database_cross_reference: HPO:HP:0031035
database_cross_reference: MDR:10076201
database_cross_reference: SNMI:DE-00003
database_cross_reference: SNOMEDCT_US:176130006
database_cross_reference: SNOMEDCT_US:177010002
database_cross_reference: SNOMEDCT_US:42017001

Immune dysregulation
type: Class
subclass of: Abnormality of immune system physiology
Definition: Altered immune function characterized by lymphoid proliferation, immune activation, and excessive autoreactivity often leading to autoimmune/inflammatory complications.
MCID: MC01398901
PMOID: PMO:00008601
Subclass_of: Abnormality of immune system physiology
Synonym: Unregulated immune response
Tree Number: T3.15.2.9
database_cross_reference: HPO:HP:0002958

Immunodeficiency
type: Class
subclass of: Abnormality of immune system physiology
Definition: Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.
MCID: MC00006762
PMOID: PMO:00008602
Subclass_of: Abnormality of immune system physiology
Synonym: DEFIC SYNDROME IMMUNOL
Synonym: DEFIC SYNDROMES IMMUNOL
Synonym: Decreased immune function
Synonym: Deficiency Syndrome, Immunologic
Synonym: Deficiency Syndrome, Immunological
Synonym: Deficiency Syndromes, Immunologic
Synonym: Deficiency Syndromes, Immunological
Synonym: Deficiency;immune
Synonym: IMMUNODEFICIENCY
Synonym: IMMUNOL DEFIC SYNDROME
Tree Number: T3.15.2.10
database_cross_reference: AOD:0000004832
database_cross_reference: CCPSS:1007151
database_cross_reference: CHV:0000006602
database_cross_reference: CHV:0000049889
database_cross_reference: COSTAR:U000355
database_cross_reference: CSP:1553-9570
database_cross_reference: CSP:1560-5885
database_cross_reference: DO:DOID:612
database_cross_reference: HPO:HP:0002721
database_cross_reference: ICD10:D84.9
database_cross_reference: ICD10AM:D84.9
database_cross_reference: ICD10CM:D84.9
database_cross_reference: ICD9CM:279.3
database_cross_reference: ICPC2P:B99011
database_cross_reference: LCH_NW:sh85064574
database_cross_reference: LNC:LP231628-1
database_cross_reference: LNC:MTHU054768
database_cross_reference: MDR:10021451
database_cross_reference: MDR:10021460
database_cross_reference: MDR:10045922
database_cross_reference: MDR:10061598
database_cross_reference: MEDCIN:39922
database_cross_reference: MSH:D007153
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3131
database_cross_reference: NCI:C39725
database_cross_reference: NCI_FDA:2156
database_cross_reference: NCI_NCI-GLOSS:CDR0000045724
database_cross_reference: NCI_NCI-GLOSS:CDR0000046357
database_cross_reference: NCI_NICHD:C39725
database_cross_reference: NDFRT:N0000001667
database_cross_reference: OMIM:MTHU007447
database_cross_reference: OMIM:MTHU032911
database_cross_reference: RCD:C393.
database_cross_reference: RCD:X20GZ
database_cross_reference: SNM:D-4600
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:F-C0450
database_cross_reference: SNOMEDCT_US:191005003
database_cross_reference: SNOMEDCT_US:234532001
database_cross_reference: SNOMEDCT_US:64431000
database_cross_reference: SNOMEDCT_VET:234532001

Immunologic hypersensitivity
type: Class
subclass of: Abnormality of immune system physiology
Definition: Immunological states where the immune system produces harmful responses upon reexposure to sensitising antigens.
MCID: MC00080661
PMOID: PMO:00008608
Subclass_of: Abnormality of immune system physiology
Synonym: Hypersensitivity (Immunologic)
Synonym: Immunologic Hypersensitivity
Tree Number: T3.15.2.11
database_cross_reference: HPO:HP:0100326
database_cross_reference: MTH:NOCODE
database_cross_reference: PSY:23810

Impaired antigen-specific response
type: Class
subclass of: Abnormality of immune system physiology
Definition: An impaired immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
MCID: MC01398907
PMOID: PMO:00008623
Subclass_of: Abnormality of immune system physiology
Synonym: Impaired adaptive immune response
Tree Number: T3.15.2.12
database_cross_reference: HPO:HP:0031404

Opportunistic infection
type: Class
subclass of: Abnormality of immune system physiology
Definition: An infection that is caused by a pathogen that would generally not be able to cause an infection in a host with a normal immune system. Such pathogens take advantage of the opportunity, so to speak, that is provided by a weakened immune system.
MCID: MC00009195
PMOID: PMO:00008626
Subclass_of: Abnormality of immune system physiology
Synonym: Infection, Opportunistic
Synonym: Infections, Opportunistic
Synonym: OI
Synonym: OIs
Synonym: OPPORTUNISTIC INFECT
Synonym: OPPORTUNISTIC INFECTION
Synonym: Opportunistic Infection
Synonym: Opportunistic Infections
Synonym: Opportunistic Infections [Disease/Finding]
Synonym: Opportunistic infections
Tree Number: T3.15.2.13
database_cross_reference: AOD:0000004784
database_cross_reference: CCPSS:0054516
database_cross_reference: CHV:0000008975
database_cross_reference: CSP:0715-7200
database_cross_reference: HPO:HP:0031690
database_cross_reference: LCH:U003362
database_cross_reference: LCH_NW:sh85095114
database_cross_reference: MDR:10030901
database_cross_reference: MEDLINEPLUS:1503
database_cross_reference: MSH:D009894
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3289
database_cross_reference: NCI_NCI-GLOSS:CDR0000256572
database_cross_reference: NCI_NICHD:C3289
database_cross_reference: NDFRT:N0000002225
database_cross_reference: OMIM:MTHU007455
database_cross_reference: SNM:D-0109
database_cross_reference: SNMI:DE-01100
database_cross_reference: SNOMEDCT_US:61274003

Recurrent infections
type: Class
subclass of: Abnormality of immune system physiology
Definition: Increased susceptibility to infections.
MCID: MC01400747
PMOID: PMO:00008637
Subclass_of: Abnormality of immune system physiology
Synonym: Frequent infections
Synonym: Frequent, severe infections
Synonym: Increased frequency of infection
Synonym: Predisposition to infections
Synonym: Susceptibility to infection
Synonym: infections, recurrent
Tree Number: T3.15.2.14
database_cross_reference: HPO:HP:0002719

Sepsis
type: Class
subclass of: Abnormality of immune system physiology
Definition: Systemic inflammatory response to infection.
MCID: MC00011758
PMOID: PMO:00008683
Subclass_of: Abnormality of immune system physiology
Synonym: (Septicaemia NOS) or (sepsis)
Synonym: (Septicaemia NOS) or (sepsis) (disorder)
Synonym: (Septicemia NOS) or (sepsis)
Synonym: BLOOD POIS
Synonym: BLOOD POISONING
Synonym: Blood Poisoning
Synonym: Blood Poisonings
Synonym: Blood poisoning
Synonym: Blood poisoning, NOS
Synonym: POIS BLOOD
Tree Number: T3.15.2.15
database_cross_reference: AOD:0000004501
database_cross_reference: AOD:0000023002
database_cross_reference: CCPSS:1009808
database_cross_reference: CHV:0000011211
database_cross_reference: COSTAR:U000614
database_cross_reference: CSP:0456-1801
database_cross_reference: CSP:5003-0039
database_cross_reference: CST:SEPSIS
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001730
database_cross_reference: DXP:U003496
database_cross_reference: HPO:HP:0100806
database_cross_reference: ICD10:A41.9
database_cross_reference: ICD10AM:A41.9
database_cross_reference: ICD10AMAE:A41.9
database_cross_reference: ICD10CM:A41.9
database_cross_reference: ICD9CM:038
database_cross_reference: ICD9CM:038.9
database_cross_reference: ICPC2P:A78006
database_cross_reference: ICPC2P:A78023
database_cross_reference: LCH:U004268
database_cross_reference: LCH_NW:sh85120119
database_cross_reference: LNC:MTHU020833
database_cross_reference: MDR:10040072
database_cross_reference: MDR:10040082
database_cross_reference: MDR:10040089
database_cross_reference: MDR:10046161
database_cross_reference: MDR:10060437
database_cross_reference: MEDCIN:30873
database_cross_reference: MEDLINEPLUS:3210
database_cross_reference: MSH:D018805
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:038.9
database_cross_reference: NCI:C3364
database_cross_reference: NCI_CTCAE:E11560
database_cross_reference: NCI_FDA:2067
database_cross_reference: NCI_NCI-GLOSS:CDR0000044348
database_cross_reference: NCI_NCI-GLOSS:CDR0000045088
database_cross_reference: NCI_NCI-GLOSS:CDR0000476299
database_cross_reference: NCI_NCI-GLOSS:CDR0000476300
database_cross_reference: NCI_NICHD:C3364
database_cross_reference: NDFRT:N0000002716
database_cross_reference: OMIM:MTHU043659
database_cross_reference: RCD:A38..
database_cross_reference: RCD:Ayu3J
database_cross_reference: RCD:XE0Qx
database_cross_reference: RCDAE:A38..
database_cross_reference: RCDAE:Ayu3J
database_cross_reference: RCDAE:XE0Qx
database_cross_reference: RCDSY:Ayu3J
database_cross_reference: SNM:D-0080
database_cross_reference: SNMI:DD-80060
database_cross_reference: SNMI:DE-00020
database_cross_reference: SNOMEDCT_US:105592009
database_cross_reference: SNOMEDCT_US:154313001
database_cross_reference: SNOMEDCT_US:186392004
database_cross_reference: SNOMEDCT_US:187333004
database_cross_reference: SNOMEDCT_US:266089004
database_cross_reference: SNOMEDCT_US:40555009
database_cross_reference: SNOMEDCT_US:91302008

Abnormality of the lymphatic system
type: Class
subclass of: Abnormality of the immune system
Definition: An anomaly of the lymphatic system, a network of lymphatic vessels that carry a clear fluid called lymph unidirectionally towards either the right lymphatic duct or the thoracic duct, which in turn drain into the right and left subclavian veins respectively.
MCID: MC01000490
PMOID: PMO:00008685
Subclass_of: Abnormality of the immune system
Tree Number: T3.15.3
database_cross_reference: HPO:HP:0100763

Abnormal pulmonary lymphatics
type: Class
subclass of: Abnormality of the lymphatic system
Definition: An abnormality of the pulmonary lymphatic chain.
MCID: MC01002549
PMOID: PMO:00008686
Subclass_of: Abnormality of the lymphatic system
Tree Number: T3.15.3.1
database_cross_reference: HPO:HP:0006529

Abnormality of the lymph nodes
type: Class
subclass of: Abnormality of the lymphatic system
Definition: A lymph node abnormality.
MCID: MC01396385
PMOID: PMO:00008688
Subclass_of: Abnormality of the lymphatic system
Synonym: Abnormal lymph node histology
Tree Number: T3.15.3.2
database_cross_reference: HPO:HP:0002733

Abnormality of the spleen
type: Class
subclass of: Abnormality of the lymphatic system
Definition: An abnormality of the spleen.
MCID: MC01003025
PMOID: PMO:00008699
Subclass_of: Abnormality of the lymphatic system
Tree Number: T3.15.3.3
database_cross_reference: HPO:HP:0001743

Abnormality of the tonsils
type: Class
subclass of: Abnormality of the lymphatic system
Definition: An abnormality of the tonsils.
MCID: MC01000489
PMOID: PMO:00008715
Subclass_of: Abnormality of the lymphatic system
Tree Number: T3.15.3.4
database_cross_reference: HPO:HP:0100765

Lymphangioma
type: Class
subclass of: Abnormality of the lymphatic system
Definition: Lymphangiomas are rare congenital malformations consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures. Lymphangioma is usually asymptomatic due to its soft consistency but compression of adjacent structures can be seen due to the mass effect of a large tumor.
MCID: MC00007737
PMOID: PMO:00008728
Subclass_of: Abnormality of the lymphatic system
Synonym: Benign lymphangioma
Synonym: Benign lymphangioma (morphologic abnormality)
Synonym: Congenital lymphangioma
Synonym: Congenital lymphangioma (disorder)
Synonym: LYMPHANGIOMA
Synonym: LYMPHANGIOMA, BENIGN
Synonym: Lymphangioma (disorder)
Synonym: Lymphangioma NOS
Synonym: Lymphangioma [Disease/Finding]
Synonym: Lymphangioma morphology
Tree Number: T3.15.3.5
database_cross_reference: CCPSS:1006008
database_cross_reference: CHV:0000007598
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2004-0139
database_cross_reference: DO:DOID:1475
database_cross_reference: HPO:HP:0100764
database_cross_reference: ICD10:D18.1
database_cross_reference: ICD10AM:D18.1
database_cross_reference: ICD10AM:M9170/0
database_cross_reference: ICD10CM:D18.1
database_cross_reference: ICD9CM:228.1
database_cross_reference: ICPC2P:K72007
database_cross_reference: ICPC2P:K99046
database_cross_reference: MDR:10025219
database_cross_reference: MDR:10025220
database_cross_reference: MEDCIN:30773
database_cross_reference: MSH:D008202
database_cross_reference: MTHICD9:228.1
database_cross_reference: NCI:C8965
database_cross_reference: NCI_CDISC:C8965
database_cross_reference: NCI_NICHD:C8965
database_cross_reference: NDFRT:N0000001894
database_cross_reference: OMIM:MTHU015908
database_cross_reference: RCD:BBU0.
database_cross_reference: RCD:X77p7
database_cross_reference: RCD:X78WK
database_cross_reference: RCD:Xa9AT
database_cross_reference: RCDSY:BBU0.
database_cross_reference: SNM:M-9170/0
database_cross_reference: SNMI:D3-F0700
database_cross_reference: SNMI:M-91700
database_cross_reference: SNOMEDCT_US:154625006
database_cross_reference: SNOMEDCT_US:189200000
database_cross_reference: SNOMEDCT_US:189875000
database_cross_reference: SNOMEDCT_US:253057002
database_cross_reference: SNOMEDCT_US:254836000
database_cross_reference: SNOMEDCT_US:269646001
database_cross_reference: SNOMEDCT_US:400178008
database_cross_reference: SNOMEDCT_US:69044001
database_cross_reference: SNOMEDCT_US:93168006

Abnormality of the integument
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the integument, which consists of the skin and the superficial fascia.
MCID: MC01003037
PMOID: PMO:00008730
Subclass_of: Phenotypic Abnormality
Tree Number: T3.16
database_cross_reference: HPO:HP:0001574

Abnormality of skin adnexa morphology
type: Class
subclass of: Abnormality of the integument
Definition: An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands.
PMOID: PMO:00008731
Subclass_of: Abnormality of the integument
Tree Number: T3.16.1

Abnormality of the hair
type: Class
subclass of: Abnormality of skin adnexa morphology
Definition: An abnormality of the hair.
MCID: MC01396382
PMOID: PMO:00008732
Subclass_of: Abnormality of skin adnexa morphology
Synonym: Hair abnormality
Tree Number: T3.16.1.1
database_cross_reference: HPO:HP:0001595

Abnormality of the nail
type: Class
subclass of: Abnormality of skin adnexa morphology
Definition: Abnormality of the nail.
PMOID: PMO:00008840
Subclass_of: Abnormality of skin adnexa morphology
Tree Number: T3.16.1.2

Abnormality of the sweat gland
type: Class
subclass of: Abnormality of skin adnexa morphology
Definition: An abnormality of the sweat gland.
PMOID: PMO:00008922
Subclass_of: Abnormality of skin adnexa morphology
Tree Number: T3.16.1.3

Skin appendage neoplasm
type: Class
subclass of: Abnormality of skin adnexa morphology
Definition: A benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands.
MCID: MC00122742
PMOID: PMO:00008931
Subclass_of: Abnormality of skin adnexa morphology
Synonym: Adnexal Neoplasm of skin
Synonym: Adnexal Neoplasm of the skin
Synonym: Adnexal Tumor of skin
Synonym: Adnexal Tumor of the skin
Synonym: Adnexal and skin appendage neoplasm (morphologic abnormality)
Synonym: Adnexal and skin appendage neoplasm NOS (morphologic abnormality)
Synonym: Adnexal and skin appendage tumor (qualifier value)
Synonym: Cutaneous Adnexal Neoplasm
Synonym: Epidermal Appendage Neoplasm
Synonym: Epidermal Appendage Tumor
Tree Number: T3.16.1.4
database_cross_reference: DO:DOID:2433
database_cross_reference: DO:DOID:3899
database_cross_reference: HPO:HP:0012842
database_cross_reference: MDR:10045153
database_cross_reference: MEDCIN:355117
database_cross_reference: NCI:C4463
database_cross_reference: RCD:X78Rm
database_cross_reference: RCD:XM1FH
database_cross_reference: RCDAE:X78Rm
database_cross_reference: RCDAE:XM1FH
database_cross_reference: SNM:M-8390/0
database_cross_reference: SNMI:M-83900
database_cross_reference: SNOMEDCT_US:126489007
database_cross_reference: SNOMEDCT_US:55681005

Abnormality of skin adnexa physiology
type: Class
subclass of: Abnormality of the integument
Definition: Any functional anomaly of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands.
MCID: MC01396362
PMOID: PMO:00008943
Subclass_of: Abnormality of the integument
Tree Number: T3.16.2
database_cross_reference: HPO:HP:0025276

Anhidrosis
type: Class
subclass of: Abnormality of skin adnexa physiology
Definition: Inability to sweat.
MCID: MC00000937
PMOID: PMO:00008944
Subclass_of: Abnormality of skin adnexa physiology
Synonym: ANHIDROSIS
Synonym: ANHYDROSIS
Synonym: Absence of sweating
Synonym: Absence of sweating (finding)
Synonym: Absent sweating
Synonym: Adiaphoresis
Synonym: Anhidrosis (disorder)
Synonym: Anhydrosis
Synonym: Lack of sweating
Synonym: SWEATING ABSENCE
Tree Number: T3.16.2.1
database_cross_reference: CHV:0000001189
database_cross_reference: CST:SWEAT DEC
database_cross_reference: DO:DOID:11156
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000119
database_cross_reference: DXP:U003898
database_cross_reference: HPO:HP:0000970
database_cross_reference: ICD10:L74.4
database_cross_reference: ICD10AM:L74.4
database_cross_reference: ICD10CM:L74.4
database_cross_reference: ICD9CM:705.0
database_cross_reference: LCH_NW:sh85005149
database_cross_reference: MDR:10002512
database_cross_reference: MDR:10002513
database_cross_reference: MEDCIN:310758
database_cross_reference: MEDCIN:6118
database_cross_reference: MSH:D007007
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34385
database_cross_reference: OMIM:MTHU001816
database_cross_reference: RCD:X76A2
database_cross_reference: RCD:XE1BK
database_cross_reference: SNM:F-03305
database_cross_reference: SNMI:D0-52010
database_cross_reference: SNMI:F-42205
database_cross_reference: SNOMEDCT_US:14662005
database_cross_reference: SNOMEDCT_US:156414006
database_cross_reference: SNOMEDCT_US:201189007
database_cross_reference: SNOMEDCT_US:39659002
database_cross_reference: SNOMEDCT_VET:39659002

Cold-induced sweating
type: Class
subclass of: Abnormality of skin adnexa physiology
Definition: Sweating provoked by cold temperature rather than by heat.
MCID: MC01397357
PMOID: PMO:00008945
Subclass_of: Abnormality of skin adnexa physiology
Tree Number: T3.16.2.2
database_cross_reference: HPO:HP:0025278

Generalized anhidrosis
type: Class
subclass of: Abnormality of skin adnexa physiology
MCID: MC01398504
PMOID: PMO:00008946
Subclass_of: Abnormality of skin adnexa physiology
Synonym: Generalized inability to sweat
Tree Number: T3.16.2.3
database_cross_reference: HPO:HP:0007459

Gustatory sweating
type: Class
subclass of: Abnormality of skin adnexa physiology
Definition: Hyperhidrosis that occurs with gustatory stimulation (e.g., moisture on face from sweating that occurs after eating).
MCID: MC00012469
PMOID: PMO:00008947
Subclass_of: Abnormality of skin adnexa physiology
Synonym: Baillarger syndrome
Synonym: Frey syndrome
Synonym: Gustatory Hyperhidroses
Synonym: Gustatory Hyperhidrosis
Synonym: Gustatory Sweating
Synonym: Gustatory hyperhidrosis
Synonym: Gustatory hyperhidrosis (disorder)
Synonym: Gustatory sweating (finding)
Synonym: HYPERHIDROSIS, GUSTATORY
Synonym: HYPRG
Tree Number: T3.16.2.4
database_cross_reference: CHV:0000011954
database_cross_reference: DO:DOID:11599
database_cross_reference: HPO:HP:0025277
database_cross_reference: MSH:D013547
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002869
database_cross_reference: OMIM:144100
database_cross_reference: RCD:X50AV
database_cross_reference: SNM:F-03640
database_cross_reference: SNMI:F-42270
database_cross_reference: SNOMEDCT_US:238758008
database_cross_reference: SNOMEDCT_US:56046002

Hypohidrosis or hyperhidrosis
type: Class
subclass of: Abnormality of skin adnexa physiology
MCID: MC01000378
PMOID: PMO:00008948
Subclass_of: Abnormality of skin adnexa physiology
Synonym: Lack of sweating or excessive sweating
Tree Number: T3.16.2.5
database_cross_reference: HPO:HP:0007550

Ipsilateral lack of facial sweating
type: Class
subclass of: Abnormality of skin adnexa physiology
MCID: MC01399352
PMOID: PMO:00008953
Subclass_of: Abnormality of skin adnexa physiology
Tree Number: T3.16.2.6
database_cross_reference: HPO:HP:0007451

Abnormality of the skin
type: Class
subclass of: Abnormality of the integument
Definition: An abnormality of the skin.
MCID: MC00011919
PMOID: PMO:00008954
Subclass_of: Abnormality of the integument
Synonym: 4-40 CONGENITAL ANOMALIES OF THE SKIN
Synonym: ABNORM SKIN
Synonym: Abnormalities, Skin
Synonym: Abnormality, Skin
Synonym: CONGENITAL ANOMALIES OF THE SKIN
Synonym: Congen.integument anomalies
Synonym: Congenital Abnormality of the Skin
Synonym: Congenital Cutaneous Malformations
Synonym: Congenital Skin Disorder
Synonym: Congenital anomaly of integument, NOS
Tree Number: T3.16.3
database_cross_reference: CHV:0000011388
database_cross_reference: CSP:0726-8244
database_cross_reference: DO:DOID:609
database_cross_reference: HPO:HP:0000951
database_cross_reference: ICD10:Q82.9
database_cross_reference: ICD10AM:Q82.9
database_cross_reference: ICD10CM:Q82.9
database_cross_reference: ICPC2P:S83001
database_cross_reference: LCH_NW:sh87001845
database_cross_reference: MDR:10040888
database_cross_reference: MDR:10067769
database_cross_reference: MEDCIN:211334
database_cross_reference: MSH:D012868
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C97174
database_cross_reference: NCI_NICHD:C97174
database_cross_reference: NDFRT:N0000002759
database_cross_reference: RCD:PH...
database_cross_reference: RCD:XE1MX
database_cross_reference: SNM:M-25100
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-40000
database_cross_reference: SNMI:D4-40100
database_cross_reference: SNOMEDCT_US:199879009
database_cross_reference: SNOMEDCT_US:205541000
database_cross_reference: SNOMEDCT_US:205611009
database_cross_reference: SNOMEDCT_US:268292002
database_cross_reference: SNOMEDCT_US:5613003

Abnormality of skin morphology
type: Class
subclass of: Abnormality of the skin
Definition: Any morphological abnormality of the skin.
MCID: MC01001492
PMOID: PMO:00008955
Subclass_of: Abnormality of the skin
Synonym: Abnormal skin structure
Tree Number: T3.16.3.1
database_cross_reference: HPO:HP:0011121

Abnormality of skin physiology
type: Class
subclass of: Abnormality of the skin
Definition: Any abnormality of the physiological function of the skin.
MCID: MC01001491
PMOID: PMO:00009408
Subclass_of: Abnormality of the skin
Tree Number: T3.16.3.2
database_cross_reference: HPO:HP:0011122

Neoplasm of the skin
type: Class
subclass of: Abnormality of the skin
Definition: A tumor (abnormal growth of tissue) of the skin.
MCID: MC00011930
PMOID: PMO:00009419
Subclass_of: Abnormality of the skin
Synonym: Cutaneous neoplasm
Synonym: Cutaneous tumor
Synonym: Cutaneous tumour
Synonym: Dermatological tumors
Synonym: NEOPL SKIN
Synonym: NEOPLASM SKIN
Synonym: Neoplasia of the skin
Synonym: Neoplasm of Skin
Synonym: Neoplasm of skin
Synonym: Neoplasm of skin (disorder)
Tree Number: T3.16.3.3
database_cross_reference: AOD:0000023027
database_cross_reference: CCPSS:1009015
database_cross_reference: CHV:0000011397
database_cross_reference: CSP:2020-0536
database_cross_reference: CST:NEOPL SKIN
database_cross_reference: CST:SKINTUMOR
database_cross_reference: DO:DOID:3165
database_cross_reference: DXP:U003701
database_cross_reference: HPO:HP:0008069
database_cross_reference: ICPC2P:S79013
database_cross_reference: LCH_NW:sh85123187
database_cross_reference: MDR:10029098
database_cross_reference: MDR:10040897
database_cross_reference: MDR:10040940
database_cross_reference: MDR:10040941
database_cross_reference: MDR:10058215
database_cross_reference: MEDCIN:39014
database_cross_reference: MSH:D012878
database_cross_reference: MTH:102
database_cross_reference: MTH:684
database_cross_reference: MTH:685
database_cross_reference: MTH:686
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3372
database_cross_reference: NDFRT:N0000002768
database_cross_reference: PDQ:CDR0000038969
database_cross_reference: RCD:X78RN
database_cross_reference: RCDAE:X78RN
database_cross_reference: SNOMEDCT_US:126488004
database_cross_reference: SNOMEDCT_US:363230005
database_cross_reference: SNOMEDCT_VET:126488004

Abnormality of the musculature
type: Class
subclass of: Phenotypic Abnormality
Definition: Abnormality originating in one or more muscles, i.e., of the set of muscles of body.
MCID: MC01000305
PMOID: PMO:00009456
Subclass_of: Phenotypic Abnormality
Synonym: Muscular abnormality
Tree Number: T3.17
database_cross_reference: HPO:HP:0003011

Abnormal muscle morphology
type: Class
subclass of: Abnormality of the musculature
Definition: A structural abnormality of a skeletal muscle.
PMOID: PMO:00009457
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.1

Abnormality of muscle fibers
type: Class
subclass of: Abnormal muscle morphology
Definition: Any abnormality of the skeletal muscle cell. Muscle fibers are subdivided into two types. Type I fibers are fatigue-resistant and rich in oxidative enzymes (they stain light with the myosin ATPase reaction), and type II fibers are fast-contracting, fatigue-prone, and rich in glycolytic enzymes (these fibers stain darkly). Normal muscle tissue has a random distribution of type I and type II fibers.
MCID: MC01000251
PMOID: PMO:00009458
Subclass_of: Abnormal muscle morphology
Synonym: Abnormal skeletal muscle fiber morphology
Tree Number: T3.17.1.1
database_cross_reference: HPO:HP:0004303

Abnormality of muscle size
type: Class
subclass of: Abnormal muscle morphology
Definition: Abnormalities of the overall muscle bulk based on clinical observation.
MCID: MC01000944
PMOID: PMO:00009542
Subclass_of: Abnormal muscle morphology
Tree Number: T3.17.1.2
database_cross_reference: HPO:HP:0030236

Calcinosis
type: Class
subclass of: Abnormal muscle morphology
Definition: Formation of calcium deposits in any soft tissue.
MCID: MC00002099
PMOID: PMO:00009562
Subclass_of: Abnormal muscle morphology
Synonym: CALCIFICATION PATHOL
Synonym: CALCINOSIS
Synonym: Calcification
Synonym: Calcification, Pathologic
Synonym: Calcinoses
Synonym: Calcinosis (disorder)
Synonym: Calcinosis [Disease/Finding]
Synonym: Calcium Deposit(s)
Synonym: Deposit(s), Calcium
Synonym: PATHOL CALCIFICATION
Tree Number: T3.17.1.3
database_cross_reference: CHV:0000002286
database_cross_reference: CSP:0531-6043
database_cross_reference: CSP:0531-6510
database_cross_reference: CST:CALCIUM DIS
database_cross_reference: DO:DOID:182
database_cross_reference: HPO:HP:0003761
database_cross_reference: MDR:10006938
database_cross_reference: MDR:10051103
database_cross_reference: MSH:D002114
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3672
database_cross_reference: NCI_FDA:1758
database_cross_reference: NCI_NCI-GLOSS:CDR0000044317
database_cross_reference: NCI_NCI-GLOSS:CDR0000638201
database_cross_reference: NCI_NCI-GLOSS:CDR0000655127
database_cross_reference: NDFRT:N0000000644
database_cross_reference: RCD:X40QV
database_cross_reference: RCD:XC06a
database_cross_reference: SNM:M-55500
database_cross_reference: SNM:U000352
database_cross_reference: SNMI:D6-34730
database_cross_reference: SNOMEDCT_US:190863003
database_cross_reference: SNOMEDCT_US:237881004
database_cross_reference: SNOMEDCT_US:6595006

Decreased muscle mass
type: Class
subclass of: Abnormal muscle morphology
MCID: MC01397616
PMOID: PMO:00009563
Subclass_of: Abnormal muscle morphology
Synonym: Underdeveloped muscles
Tree Number: T3.17.1.4
database_cross_reference: HPO:HP:0003199

Fatty replacement of skeletal muscle
type: Class
subclass of: Abnormal muscle morphology
Definition: Muscle fibers degeneration resulting in fatty replacement of skeletal muscle fibers
MCID: MC01398301
PMOID: PMO:00009564
Subclass_of: Abnormal muscle morphology
Synonym: Skeletal muscle fatty infiltration
Tree Number: T3.17.1.5
database_cross_reference: HPO:HP:0012548

Firm muscles
type: Class
subclass of: Abnormal muscle morphology
MCID: MC01398334
PMOID: PMO:00009565
Subclass_of: Abnormal muscle morphology
Tree Number: T3.17.1.6
database_cross_reference: HPO:HP:0003725

Generalized muscular appearance from birth
type: Class
subclass of: Abnormal muscle morphology
MCID: MC01398523
PMOID: PMO:00009566
Subclass_of: Abnormal muscle morphology
Tree Number: T3.17.1.7
database_cross_reference: HPO:HP:0003716

Intramuscular hematoma
type: Class
subclass of: Abnormal muscle morphology
Definition: Blood clot formed within muscle tissue following leakage of blood into the tissue.
MCID: MC01399342
PMOID: PMO:00009567
Subclass_of: Abnormal muscle morphology
Synonym: Intramuscular haematoma
Synonym: Intramuscular hemorrhage
Tree Number: T3.17.1.8
database_cross_reference: HPO:HP:0012233

Muscle eosinophilia
type: Class
subclass of: Abnormal muscle morphology
Definition: Eosinophil infiltration of skeletal muscle.
MCID: MC01399901
PMOID: PMO:00009568
Subclass_of: Abnormal muscle morphology
Synonym: Eosinophilic infiltration of skeletal muscle
Tree Number: T3.17.1.9
database_cross_reference: HPO:HP:0032019

Muscular dystrophy
type: Class
subclass of: Abnormal muscle morphology
Definition: The term dystrophy means abnormal growth. However, muscular dystrophy is used to describe primary myopathies with a genetic basis and a progressive course characterized by progressive skeletal muscle weakness and wasting, defects in muscle proteins, and histological features of muscle fiber degeneration (necrosis) and regeneration. If possible, it is preferred to use other HPO terms to describe the precise phenotypic abnormalities.
MCID: MC00008500
PMOID: PMO:00009569
Subclass_of: Abnormal muscle morphology
Synonym: Congenital progressive muscular dystrophy
Synonym: Dystrophic Muscle Diseases and Syndromes
Synonym: Dystrophic muscle disease or syndrome
Synonym: Dystrophies, Muscular
Synonym: Dystrophy (Muscular)
Synonym: Dystrophy, Muscular
Synonym: Dystrophy;muscular
Synonym: Hered prog musc dystrphy
Synonym: Hered.progres.musc.dystr. NOS
Synonym: Heredit.progres.musc.dystrophy
Tree Number: T3.17.1.10
database_cross_reference: AOD:0000005065
database_cross_reference: CCPSS:0046013
database_cross_reference: CHV:0000008362
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-6662
database_cross_reference: DO:DOID:9884
database_cross_reference: HPO:HP:0003560
database_cross_reference: ICD10:G71.0
database_cross_reference: ICD10AM:G71.0
database_cross_reference: ICD10CM:G71.0
database_cross_reference: ICD9CM:359.1
database_cross_reference: ICPC2P:L99093
database_cross_reference: ICPC2P:N99007
database_cross_reference: LCH:U003066
database_cross_reference: LCH_NW:sh85088693
database_cross_reference: MDR:10019897
database_cross_reference: MDR:10028356
database_cross_reference: MDR:10028357
database_cross_reference: MEDCIN:32350
database_cross_reference: MEDLINEPLUS:335
database_cross_reference: MSH:D009136
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:359.1
database_cross_reference: NCI:C84910
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NICHD:C84910
database_cross_reference: NDFRT:N0000002065
database_cross_reference: OMIM:MTHU037519
database_cross_reference: PSY:15700
database_cross_reference: PSY:32610
database_cross_reference: RCD:F391.
database_cross_reference: RCD:F391z
database_cross_reference: RCD:Xa0lL
database_cross_reference: SNM:D-8020
database_cross_reference: SNM:D-8021
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DA-51100
database_cross_reference: SNMI:DA-51200
database_cross_reference: SNOMEDCT_US:155095006
database_cross_reference: SNOMEDCT_US:193225000
database_cross_reference: SNOMEDCT_US:193236007
database_cross_reference: SNOMEDCT_US:193257004
database_cross_reference: SNOMEDCT_US:267712004
database_cross_reference: SNOMEDCT_US:44292004
database_cross_reference: SNOMEDCT_US:73297009

Myopathy
type: Class
subclass of: Abnormal muscle morphology
Definition: A disorder of muscle unrelated to impairment of innervation or neuromuscular junction.
MCID: MC00008498
PMOID: PMO:00009573
Subclass_of: Abnormal muscle morphology
Synonym: A-51 MYOPATHIES
Synonym: DISORDER MUSCLE
Synonym: Disorder muscle
Synonym: Disorder of muscle
Synonym: Disorder of muscle (disorder)
Synonym: Disorder of muscle -RETIRED-
Synonym: Disorder of muscle, NOS
Synonym: Disorder of muscle, unspec
Synonym: Disorder of muscle, unspecified
Synonym: Disorder of skeletal AND/OR smooth muscle
Tree Number: T3.17.1.11
database_cross_reference: AOD:0000005063
database_cross_reference: AOD:0000005066
database_cross_reference: BI:BI00507
database_cross_reference: CCPSS:0045912
database_cross_reference: CCPSS:1018022
database_cross_reference: CHV:0000008361
database_cross_reference: COSTAR:U000457
database_cross_reference: CSP:1982-9451
database_cross_reference: CST:MS/MUS
database_cross_reference: CST:MYOPATHY
database_cross_reference: DO:DOID:0080000
database_cross_reference: DO:DOID:423
database_cross_reference: DO:DOID:66
database_cross_reference: DXP:U002703
database_cross_reference: HPO:HP:0003198
database_cross_reference: ICD10:G72.9
database_cross_reference: ICD10:M60-M63.9
database_cross_reference: ICD10:M62.9
database_cross_reference: ICD10AM:G72.9
database_cross_reference: ICD10AM:M60-M63.9
database_cross_reference: ICD10AM:M62.9
database_cross_reference: ICD10CM:G72.9
database_cross_reference: ICD10CM:M60-M63
database_cross_reference: ICD10CM:M62.9
database_cross_reference: ICD9CM:359.9
database_cross_reference: ICPC2P:L99023
database_cross_reference: LCH_NW:sh85088688
database_cross_reference: MDR:10013237
database_cross_reference: MDR:10028300
database_cross_reference: MDR:10028301
database_cross_reference: MDR:10028302
database_cross_reference: MDR:10028640
database_cross_reference: MDR:10028641
database_cross_reference: MDR:10028649
database_cross_reference: MEDCIN:319450
database_cross_reference: MEDCIN:91077
database_cross_reference: MEDLINEPLUS:510
database_cross_reference: MSH:D009135
database_cross_reference: MTH:503
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101216
database_cross_reference: NCI_NICHD:C101216
database_cross_reference: NDFRT:N0000002064
database_cross_reference: OMIM:590030
database_cross_reference: OMIM:590075
database_cross_reference: OMIM:MTHU003653
database_cross_reference: OMIM:MTHU049021
database_cross_reference: PSY:32600
database_cross_reference: RCD:Nyu8B
database_cross_reference: RCD:X708D
database_cross_reference: RCD:X708s
database_cross_reference: RCDSY:Nyu8B
database_cross_reference: SNM:D-8004
database_cross_reference: SNM:D-8060
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D1-50010
database_cross_reference: SNMI:DA-51000
database_cross_reference: SNOMEDCT_US:129565002
database_cross_reference: SNOMEDCT_US:155094005
database_cross_reference: SNOMEDCT_US:155099000
database_cross_reference: SNOMEDCT_US:203833006
database_cross_reference: SNOMEDCT_US:203845002
database_cross_reference: SNOMEDCT_US:267711006

Rhabdomyolysis
type: Class
subclass of: Abnormal muscle morphology
Definition: Breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream.
MCID: MC00011346
PMOID: PMO:00009581
Subclass_of: Abnormal muscle morphology
Synonym: Necrosis of skeletal muscle
Synonym: Necrosis of skeletal muscle (finding)
Synonym: RHABDOMYOLYSIS
Synonym: Rhabdomyolyses
Synonym: Rhabdomyolysis (disorder)
Synonym: Rhabdomyolysis (morphologic abnormality)
Synonym: Rhabdomyolysis [Disease/Finding]
Synonym: Skeletal muscle necrosis
Synonym: rhabdomyolysis
Synonym: rhabdomyolysis (diagnosis)
Tree Number: T3.17.1.12
database_cross_reference: AOD:0000005067
database_cross_reference: CCPSS:0041860
database_cross_reference: CHV:0000010835
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:RHABDO
database_cross_reference: HPO:HP:0003201
database_cross_reference: ICD10CM:M62.82
database_cross_reference: ICD9CM:728.88
database_cross_reference: LCH_NW:sh87007562
database_cross_reference: MDR:10039020
database_cross_reference: MEDCIN:272819
database_cross_reference: MEDLINEPLUS:510
database_cross_reference: MSH:D012206
database_cross_reference: NCI:C118318
database_cross_reference: NCI_NICHD:C118318
database_cross_reference: NDFRT:N0000002626
database_cross_reference: OMIM:MTHU036873
database_cross_reference: RCD:X70AI
database_cross_reference: SNM:M-51500
database_cross_reference: SNMI:M-51570
database_cross_reference: SNOMEDCT_US:156729009
database_cross_reference: SNOMEDCT_US:240131006
database_cross_reference: SNOMEDCT_US:268106003
database_cross_reference: SNOMEDCT_US:89010004
database_cross_reference: SNOMEDCT_VET:240131006
database_cross_reference: SNOMEDCT_VET:311511000009102

Skeletal muscle fibrosis
type: Class
subclass of: Abnormal muscle morphology
Definition: Excessive formation of fibrous bands of scar tissue in between muscle fibers.
MCID: MC01401165
PMOID: PMO:00009587
Subclass_of: Abnormal muscle morphology
Tree Number: T3.17.1.13
database_cross_reference: HPO:HP:0030951

Abnormality of axial muscles
type: Class
subclass of: Abnormality of the musculature
MCID: MC01396238
PMOID: PMO:00009588
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.2
database_cross_reference: HPO:HP:0040286

Axial muscle atrophy
type: Class
subclass of: Abnormality of axial muscles
MCID: MC01397005
PMOID: PMO:00009589
Subclass_of: Abnormality of axial muscles
Tree Number: T3.17.2.1
database_cross_reference: HPO:HP:0040287

Abnormality of muscle physiology
type: Class
subclass of: Abnormality of the musculature
Definition: A functional abnormality of a skeletal muscle.
MCID: MC01001252
PMOID: PMO:00009590
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.3
database_cross_reference: HPO:HP:0011804

Abnormal muscle tone
type: Class
subclass of: Abnormality of muscle physiology
MCID: MC00297269
PMOID: PMO:00009591
Subclass_of: Abnormality of muscle physiology
Synonym: Abnormal muscles tone
Synonym: Muscle tone abnormal
Tree Number: T3.17.3.1
database_cross_reference: HPO:HP:0003808
database_cross_reference: MDR:10028342
database_cross_reference: OMIM:MTHU052933

EMG abnormality
type: Class
subclass of: Abnormality of muscle physiology
Definition: Abnormal results of investigations using electromyography (EMG).
MCID: MC01398123
PMOID: PMO:00009606
Subclass_of: Abnormality of muscle physiology
Synonym: Abnormal EMG
Synonym: Abnormal electromyography finding
Synonym: EMG abnormalities
Synonym: Electromyogram abnormal
Tree Number: T3.17.3.2
database_cross_reference: HPO:HP:0003457

Functional motor deficit
type: Class
subclass of: Abnormality of muscle physiology
MCID: MC01398470
PMOID: PMO:00009609
Subclass_of: Abnormality of muscle physiology
Synonym: Functional motor problems
Tree Number: T3.17.3.3
database_cross_reference: HPO:HP:0004302

Increased muscle fatiguability
type: Class
subclass of: Abnormality of muscle physiology
Definition: An abnormal, increased fatiguability of the musculature.
MCID: MC01399147
PMOID: PMO:00009615
Subclass_of: Abnormality of muscle physiology
Tree Number: T3.17.3.4
database_cross_reference: HPO:HP:0003750

Muscle cramps
type: Class
subclass of: Abnormality of muscle physiology
Definition: Sudden and involuntary contractions of one or more muscles.
MCID: MC00008485
PMOID: PMO:00009617
Subclass_of: Abnormality of muscle physiology
Synonym: CRAMP
Synonym: CRAMP MUSCLE
Synonym: Cramp
Synonym: Cramp (disorder)
Synonym: Cramp (finding)
Synonym: Cramp in muscle
Synonym: Cramp in muscle, NOS
Synonym: Cramp muscle
Synonym: Cramp(s)
Synonym: Cramp(s);muscle(s)
Tree Number: T3.17.3.5
database_cross_reference: CCPSS:0003813
database_cross_reference: CCPSS:0059192
database_cross_reference: CHV:0000008346
database_cross_reference: COSTAR:500
database_cross_reference: COSTAR:501
database_cross_reference: CSP:1982-9552
database_cross_reference: CST:HYPERTONIA
database_cross_reference: CST:PAIN
database_cross_reference: DXP:U002675
database_cross_reference: HPO:HP:0003394
database_cross_reference: ICPC2P:L18015
database_cross_reference: ICPC2P:L19011
database_cross_reference: MDR:10011285
database_cross_reference: MDR:10011291
database_cross_reference: MDR:10011293
database_cross_reference: MDR:10028294
database_cross_reference: MDR:10028295
database_cross_reference: MEDCIN:1050
database_cross_reference: MEDLINEPLUS:1707
database_cross_reference: MSH:D009120
database_cross_reference: MTH:501
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34827
database_cross_reference: NCI_FDA:2193
database_cross_reference: NCI_NCI-GLOSS:CDR0000476584
database_cross_reference: NCI_NICHD:C34827
database_cross_reference: NDFRT:N0000002057
database_cross_reference: OMIM:MTHU002773
database_cross_reference: OMIM:MTHU004012
database_cross_reference: OMIM:MTHU022606
database_cross_reference: OMIM:MTHU035348
database_cross_reference: PSY:12320
database_cross_reference: PSY:32550
database_cross_reference: RCD:N23y4
database_cross_reference: RCD:N2472
database_cross_reference: RCD:X00CB
database_cross_reference: SNM:F-81390
database_cross_reference: SNMI:F-11700
database_cross_reference: SNOMEDCT_US:203136000
database_cross_reference: SNOMEDCT_US:55300003

Muscle hyperirritability
type: Class
subclass of: Abnormality of muscle physiology
MCID: MC01399909
PMOID: PMO:00009622
Subclass_of: Abnormality of muscle physiology
Tree Number: T3.17.3.6
database_cross_reference: HPO:HP:0003559

Muscle stiffness
type: Class
subclass of: Abnormality of muscle physiology
Definition: A condition in which muscles cannot be moved quickly without accompanying pain or spasm.
MCID: MC00070757
PMOID: PMO:00009623
Subclass_of: Abnormality of muscle physiology
Synonym: MUSCLE STIFFNESS
Synonym: Muscle Stiffness
Synonym: Muscle stiffness (finding)
Synonym: Muscular stiffness
Synonym: STIFFNESS MUSCLE
Synonym: Stiff
Synonym: Stiff Muscles
Synonym: Stiffness muscle
Synonym: Stiffness;muscle(s)
Synonym: muscle stiffness
Tree Number: T3.17.3.7
database_cross_reference: CCPSS:1016474
database_cross_reference: CHV:0000021321
database_cross_reference: CST:HYPERTONIA
database_cross_reference: HPO:HP:0003552
database_cross_reference: ICPC2P:L19008
database_cross_reference: MDR:10028339
database_cross_reference: MDR:10042048
database_cross_reference: MEDCIN:283534
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118433
database_cross_reference: NCI_NICHD:C118433
database_cross_reference: OMIM:MTHU010824
database_cross_reference: RCD:X76mk
database_cross_reference: SNM:F-89160
database_cross_reference: SNMI:F-11320
database_cross_reference: SNOMEDCT_US:16046003
database_cross_reference: SNOMEDCT_US:249919003

Muscle weakness
type: Class
subclass of: Abnormality of muscle physiology
Definition: Reduced strength of muscles.
MCID: MC00009740
PMOID: PMO:00009627
Subclass_of: Abnormality of muscle physiology
Synonym: Incomplete paralysis
Synonym: Muscle Pareses
Synonym: Muscle Paresis
Synonym: Muscular Pareses
Synonym: Muscular Paresis
Synonym: PARALYSIS PARTIAL
Synonym: PARESIS
Synonym: Pareses
Synonym: Pareses, Muscle
Synonym: Pareses, Muscular
Tree Number: T3.17.3.8
database_cross_reference: CCPSS:0009933
database_cross_reference: CCPSS:0024112
database_cross_reference: CHV:0000009312
database_cross_reference: CHV:0000047949
database_cross_reference: COSTAR:U000509
database_cross_reference: CST:PARALYSIS
database_cross_reference: ICPC2P:N18006
database_cross_reference: MDR:10033985
database_cross_reference: MSH:D010291
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C50688
database_cross_reference: NCI_FDA:1998
database_cross_reference: NDFRT:N0000002325
database_cross_reference: RCD:XM03n
database_cross_reference: SNM:F-80850
database_cross_reference: SNMI:F-A0850
database_cross_reference: SNOMEDCT_US:26544005

Myotonia
type: Class
subclass of: Abnormality of muscle physiology
Definition: An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation.
MCID: MC01399929
PMOID: PMO:00009658
Subclass_of: Abnormality of muscle physiology
Synonym: Delayed relaxation of muscle fibers after contraction
Tree Number: T3.17.3.9
database_cross_reference: HPO:HP:0002486

Tetany
type: Class
subclass of: Abnormality of muscle physiology
Definition: A condition characterized by intermittent involuntary contraction of muscles (spasms) related to hypocalcemia or occasionally magneisum deficiency.
MCID: MC00012641
PMOID: PMO:00009670
Subclass_of: Abnormality of muscle physiology
Synonym: TETANY
Synonym: Tetanies
Synonym: Tetany (disorder)
Synonym: Tetany (finding)
Synonym: Tetany NOS
Synonym: Tetany [Ambiguous]
Synonym: Tetany [Disease/Finding]
Synonym: Tetany, NOS
Synonym: [D]Tetany
Synonym: [D]Tetany (context-dependent category)
Tree Number: T3.17.3.10
database_cross_reference: AOD:0000005049
database_cross_reference: CHV:0000012127
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3848
database_cross_reference: CST:TETANY
database_cross_reference: HPO:HP:0001281
database_cross_reference: ICD10:R29.0
database_cross_reference: ICD10AM:R29.0
database_cross_reference: ICD10CM:R29.0
database_cross_reference: ICD9CM:781.7
database_cross_reference: LCH:U004625
database_cross_reference: LCH_NW:sh85134169
database_cross_reference: MDR:10043380
database_cross_reference: MEDCIN:729
database_cross_reference: MEDCIN:9008
database_cross_reference: MSH:D013746
database_cross_reference: MTH:U000234
database_cross_reference: NCI:C114789
database_cross_reference: NCI_NICHD:C114789
database_cross_reference: NDFRT:N0000002916
database_cross_reference: OMIM:MTHU037171
database_cross_reference: RCD:R017.
database_cross_reference: RCD:R017z
database_cross_reference: RCD:XM078
database_cross_reference: RCDSY:R017.
database_cross_reference: RCDSY:R017z
database_cross_reference: SNM:F-81420
database_cross_reference: SNMI:F-11370
database_cross_reference: SNOMEDCT_US:10629009
database_cross_reference: SNOMEDCT_US:154697005
database_cross_reference: SNOMEDCT_US:158212004
database_cross_reference: SNOMEDCT_US:158214003
database_cross_reference: SNOMEDCT_US:206837000
database_cross_reference: SNOMEDCT_US:206839002
database_cross_reference: SNOMEDCT_US:267479004
database_cross_reference: SNOMEDCT_US:271802009

Abnormality of occipitofrontalis muscle
type: Class
subclass of: Abnormality of the musculature
MCID: MC01019112
PMOID: PMO:00009671
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.4
database_cross_reference: HPO:HP:0040172

Abnormality of skeletal muscles
type: Class
subclass of: Abnormality of the musculature
MCID: MC01396361
PMOID: PMO:00009672
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.5
database_cross_reference: HPO:HP:0040290

Skeletal muscle atrophy
type: Class
subclass of: Abnormality of skeletal muscles
Definition: The presence of skeletal muscular atrophy (which is also known as amyotrophy).
MCID: MC00170431
PMOID: PMO:00009673
Subclass_of: Abnormality of skeletal muscles
Synonym: ATROPHY SKELETAL MUSCLE
Synonym: Amyotrophy
Synonym: Amyotrophy involving the extremities
Synonym: Atrophy skeletal muscle
Synonym: Muscle atrophy
Synonym: Muscle hypotrophy
Synonym: Muscle wasting
Synonym: Muscular atrophy
Synonym: skeletal muscle atrophy
Tree Number: T3.17.5.1
database_cross_reference: CST:ATROPHY MUSCLE
database_cross_reference: GO:GO:0014732
database_cross_reference: HPO:HP:0003202
database_cross_reference: MDR:10003718
database_cross_reference: MTH:NOCODE

Skeletal muscle hypertrophy
type: Class
subclass of: Abnormality of skeletal muscles
Definition: Hypertrophy (increase in size) of muscle cells (as opposed to hyperplasia, which refers to an increase in the number of muscle cells).
MCID: MC00697322
PMOID: PMO:00009698
Subclass_of: Abnormality of skeletal muscles
Synonym: Hypertrophic muscles
Synonym: Increased skeletal muscle cells
Synonym: Muscle hypertrophy
Synonym: Muscular hypertrophy
Synonym: skeletal muscle hypertrophy
Tree Number: T3.17.5.2
database_cross_reference: GO:GO:0014734
database_cross_reference: HPO:HP:0003712
database_cross_reference: MTH:NOCODE

Skeletal muscle steatosis
type: Class
subclass of: Abnormality of skeletal muscles
MCID: MC01401166
PMOID: PMO:00009709
Subclass_of: Abnormality of skeletal muscles
Synonym: Steatosis of skeletal muscle
Synonym: Steatosis of skeletal muscles
Tree Number: T3.17.5.3
database_cross_reference: HPO:HP:0040291

Abnormality of the back musculature
type: Class
subclass of: Abnormality of the musculature
Definition: Any abnormality of the back muscles.
MCID: MC01396371
PMOID: PMO:00009710
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.6
database_cross_reference: HPO:HP:0410168

Abnormality of the chest musculature
type: Class
subclass of: Abnormality of the musculature
Definition: Any abnormality of the chest muscles.
MCID: MC01396377
PMOID: PMO:00009711
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.7
database_cross_reference: HPO:HP:0410167

Abnormality of the diaphragm
type: Class
subclass of: Abnormality of the musculature
Definition: Any abnormality of the diaphragm, the sheet of skeletal muscle that separates the thoracic cavity from the abdominal cavity.
MCID: MC01396380
PMOID: PMO:00009712
Subclass_of: Abnormality of the musculature
Synonym: Diaphragm issues
Synonym: Diaphragmatic defect
Tree Number: T3.17.8
database_cross_reference: HPO:HP:0000775

Abnormality of the hemidiaphragms
type: Class
subclass of: Abnormality of the diaphragm
MCID: MC01000899
PMOID: PMO:00009713
Subclass_of: Abnormality of the diaphragm
Tree Number: T3.17.8.1
database_cross_reference: HPO:HP:0040045

Aplasia/Hypoplasia of the diaphragm
type: Class
subclass of: Abnormality of the diaphragm
Definition: Absence or underdevelopment of the diaphragm.
MCID: MC01396846
PMOID: PMO:00009718
Subclass_of: Abnormality of the diaphragm
Synonym: Absent/small diaprhagm
Synonym: Absent/underdeveloped diaprhagm
Tree Number: T3.17.8.2
database_cross_reference: HPO:HP:0010315

Denervation of the diaphragm
type: Class
subclass of: Abnormality of the diaphragm
Definition: Interruption of the innervation of the diaphragm.
MCID: MC01397772
PMOID: PMO:00009721
Subclass_of: Abnormality of the diaphragm
Tree Number: T3.17.8.3
database_cross_reference: HPO:HP:0009109

Diaphragmatic eventration
type: Class
subclass of: Abnormality of the diaphragm
Definition: A congenital failure of muscular development of part or all of one or both hemidiaphragms, resulting in superior displacement of abdominal viscera and altered lung development.
MCID: MC00003819
PMOID: PMO:00009722
Subclass_of: Abnormality of the diaphragm
Synonym: DIAPHRAGM, EVENTRATION
Synonym: DIAPHRAGMATIC EVENTRATION
Synonym: Diaphragm Eventration
Synonym: Diaphragm eventration
Synonym: Diaphragmatic Eventration
Synonym: Diaphragmatic Eventration [Disease/Finding]
Synonym: Diaphragmatic eventration (disorder)
Synonym: Eventration of Diaphragm
Synonym: Eventration of diaphragm
Synonym: Eventration of the diaphragm
Tree Number: T3.17.8.4
database_cross_reference: CHV:0000003864
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10480
database_cross_reference: DXP:U000477
database_cross_reference: HPO:HP:0009110
database_cross_reference: ICD10CM:Q79.1
database_cross_reference: MEDCIN:33006
database_cross_reference: MSH:D003965
database_cross_reference: MTHICD9:756.6
database_cross_reference: NCI:C98912
database_cross_reference: NCI_CDISC:C98912
database_cross_reference: NCI_NICHD:C98912
database_cross_reference: NDFRT:N0000000961
database_cross_reference: OMIM:MTHU037386
database_cross_reference: OMIM:MTHU037914
database_cross_reference: OMIM:MTHU038310
database_cross_reference: SNM:M-31410
database_cross_reference: SNMI:D2-82060
database_cross_reference: SNOMEDCT_US:157006001
database_cross_reference: SNOMEDCT_US:268351009
database_cross_reference: SNOMEDCT_US:34168003

Diaphragmatic weakness
type: Class
subclass of: Abnormality of the diaphragm
Definition: A decrease in the strength of the diaphragm.
MCID: MC01397803
PMOID: PMO:00009723
Subclass_of: Abnormality of the diaphragm
Synonym: Diaphragmatic paraparesis
Synonym: Weak diaphragm
Tree Number: T3.17.8.5
database_cross_reference: HPO:HP:0009113

Abnormality of the musculature of the neck
type: Class
subclass of: Abnormality of the musculature
Definition: An abnormality of the neck musculature.
MCID: MC01001532
PMOID: PMO:00009725
Subclass_of: Abnormality of the musculature
Synonym: Abnormality of cervical musculature
Tree Number: T3.17.9
database_cross_reference: HPO:HP:0011006

Abnormality of geniohyoid muscle
type: Class
subclass of: Abnormality of the musculature of the neck
Definition: An abnormality of a geniohyoid muscle.
MCID: MC01019189
PMOID: PMO:00009726
Subclass_of: Abnormality of the musculature of the neck
Tree Number: T3.17.9.1
database_cross_reference: HPO:HP:3000046

Abnormality of platysma
type: Class
subclass of: Abnormality of the musculature of the neck
Definition: An abnormality of the platysma muscle.
MCID: MC01019159
PMOID: PMO:00009727
Subclass_of: Abnormality of the musculature of the neck
Synonym: Abnormality of the platysma muscle
Tree Number: T3.17.9.2
database_cross_reference: HPO:HP:3000013

Congenital muscular torticollis
type: Class
subclass of: Abnormality of the musculature of the neck
Definition: A congenital form of torticollis resulting from shortening of the sternocleidomastoid muscle and leading to a limited range of motion in both rotation and lateral bending.
MCID: MC00041074
PMOID: PMO:00009728
Subclass_of: Abnormality of the musculature of the neck
Synonym: Congen.sternomastoid torticol.
Synonym: Congenital (sternomastoid) torticollis
Synonym: Congenital contracture of sternocleidomastoid
Synonym: Congenital contracture of sternocleidomastoid (muscle)
Synonym: Congenital contracture of sternocleidomastoid muscle
Synonym: Congenital sternomastoid torticollis
Synonym: Congenital sternomastoid torticollis (disorder)
Synonym: Congenital sternomastoid torticollis (disorder) [Ambiguous]
Synonym: Congenital sternomastoid torticollis -RETIRED-
Synonym: Congenital torticollis
Tree Number: T3.17.9.3
database_cross_reference: CHV:0000015158
database_cross_reference: HPO:HP:0005988
database_cross_reference: ICD10CM:Q68.0
database_cross_reference: MDR:10010650
database_cross_reference: MEDCIN:35841
database_cross_reference: MSH:C535425
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:754.1
database_cross_reference: OMIM:MTHU016978
database_cross_reference: RCD:XE1LV
database_cross_reference: SNMI:D4-B2082
database_cross_reference: SNOMEDCT_US:123272007
database_cross_reference: SNOMEDCT_US:156999009
database_cross_reference: SNOMEDCT_US:205041007
database_cross_reference: SNOMEDCT_US:25699004
database_cross_reference: SNOMEDCT_US:268240006
database_cross_reference: SNOMEDCT_US:268345004

Neck muscle hypertrophy
type: Class
subclass of: Abnormality of the musculature of the neck
Definition: Muscle hypertrophy affecting the muscles of the neck.
MCID: MC01399977
PMOID: PMO:00009729
Subclass_of: Abnormality of the musculature of the neck
Synonym: Hypertrophy of cervical muscles
Synonym: Large neck muscles
Synonym: Overgrowth of neck muscles
Tree Number: T3.17.9.4
database_cross_reference: HPO:HP:0012893

Abnormality of the musculature of the pelvis
type: Class
subclass of: Abnormality of the musculature
MCID: MC01003043
PMOID: PMO:00009730
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.10
database_cross_reference: HPO:HP:0001469

Abnormality of the gluteal musculature
type: Class
subclass of: Abnormality of the musculature of the pelvis
MCID: MC01003054
PMOID: PMO:00009731
Subclass_of: Abnormality of the musculature of the pelvis
Synonym: Abnormality of glutes
Tree Number: T3.17.10.1
database_cross_reference: HPO:HP:0001443

Abnormality of the hip-girdle musculature
type: Class
subclass of: Abnormality of the musculature of the pelvis
MCID: MC01003052
PMOID: PMO:00009732
Subclass_of: Abnormality of the musculature of the pelvis
Tree Number: T3.17.10.2
database_cross_reference: HPO:HP:0001445

Aplasia/Hypoplasia of the musculature of the pelvis
type: Class
subclass of: Abnormality of the musculature of the pelvis
MCID: MC01396882
PMOID: PMO:00009735
Subclass_of: Abnormality of the musculature of the pelvis
Synonym: Absent/small pelvis muscles
Synonym: Absent/underdeveloped pelvis muscles
Tree Number: T3.17.10.3
database_cross_reference: HPO:HP:0001471

Abnormality of the musculature of the thorax
type: Class
subclass of: Abnormality of the musculature
Definition: A disease or lesion affecting the muscles of the thorax.
MCID: MC01002295
PMOID: PMO:00009739
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.11
database_cross_reference: HPO:HP:0009131

Abnormality of the pectoral muscle
type: Class
subclass of: Abnormality of the musculature of the thorax
Definition: An abnormality of the pectoral muscle, comprising the pectoralis major, a thick, fan-shaped muscle of the anterior chest and the pectoralis minor, a thin, triangular muscle situated underneath the pectoralis major.
MCID: MC01001207
PMOID: PMO:00009740
Subclass_of: Abnormality of the musculature of the thorax
Synonym: Abnormal pec muscles
Tree Number: T3.17.11.1
database_cross_reference: HPO:HP:0011957

Hypoplasia of latissimus dorsi muscle
type: Class
subclass of: Abnormality of the musculature of the thorax
Definition: Underdevelopment of the latissimus dorsi muscle, which is involved in adduction, extension, internal rotation, and transverse extension of the shoulder and assists in movement of the scapula.
MCID: MC01398781
PMOID: PMO:00009746
Subclass_of: Abnormality of the musculature of the thorax
Tree Number: T3.17.11.2
database_cross_reference: HPO:HP:0009026

Hypoplasia of serratus anterior muscle
type: Class
subclass of: Abnormality of the musculature of the thorax
Definition: Underdevelopment of the serratus anterior muscle, which is involved in abduction, upward Rotation, and elevation of the scapula.
MCID: MC01398786
PMOID: PMO:00009747
Subclass_of: Abnormality of the musculature of the thorax
Tree Number: T3.17.11.3
database_cross_reference: HPO:HP:0009011

Abnormality of the shoulder musculature
type: Class
subclass of: Abnormality of the musculature
Definition: Any abnormality of the shoulder muscles.
MCID: MC01396401
PMOID: PMO:00009748
Subclass_of: Abnormality of the musculature
Synonym: Muscle issues in the shoulder
Tree Number: T3.17.12
database_cross_reference: HPO:HP:0410169

Calcification of muscles
type: Class
subclass of: Abnormality of the musculature
Definition: Deposition of calcium salts in muscle tissue.
MCID: MC00807337
PMOID: PMO:00009749
Subclass_of: Abnormality of the musculature
Synonym: Calcification of muscle
Synonym: Calcification of muscle (disorder)
Synonym: MUSCLE CALCIFICATION
Synonym: Muscular calcification
Synonym: Muscular calcification (disorder)
Synonym: Muscular calcification, NOS
Synonym: Skeletal muscle calcinosis
Synonym: calcification of muscle
Synonym: calcification of muscle (diagnosis)
Tree Number: T3.17.13
database_cross_reference: DXP:U002672
database_cross_reference: HPO:HP:0100249
database_cross_reference: MDR:10049797
database_cross_reference: MEDCIN:331452
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:D1-50200
database_cross_reference: SNOMEDCT_US:446993003
database_cross_reference: SNOMEDCT_US:57879007

Increased intramuscular fat
type: Class
subclass of: Abnormality of the musculature
Definition: An abnormal increase in the amount of intramuscular fat tissue.
MCID: MC01399099
PMOID: PMO:00009750
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.14
database_cross_reference: HPO:HP:0008985

Muscle abnormality related to mitochondrial dysfunction
type: Class
subclass of: Abnormality of the musculature
MCID: MC01002927
PMOID: PMO:00009751
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.15
database_cross_reference: HPO:HP:0003800

Cytochrome C oxidase-negative muscle fibers
type: Class
subclass of: Muscle abnormality related to mitochondrial dysfunction
Definition: An abnormally reduced activity of the enzyme cytochrome C oxidase in muscle tissue.
MCID: MC01397478
PMOID: PMO:00009752
Subclass_of: Muscle abnormality related to mitochondrial dysfunction
Synonym: Cytochrome c oxidase deficiency in skeletal muscle
Synonym: Decreased activity of cytochrome C oxidase in muscle tissue
Synonym: Decreased skeletal muscle cytochrome c oxidase activity
Tree Number: T3.17.15.1
database_cross_reference: HPO:HP:0003688

Depletion of mitochondrial DNA in muscle tissue
type: Class
subclass of: Muscle abnormality related to mitochondrial dysfunction
MCID: MC01397782
PMOID: PMO:00009753
Subclass_of: Muscle abnormality related to mitochondrial dysfunction
Synonym: Depletion of mitochondrial dna in skeletal muscle tissue
Tree Number: T3.17.15.2
database_cross_reference: HPO:HP:0009141

Mitochondrial myopathy
type: Class
subclass of: Muscle abnormality related to mitochondrial dysfunction
Definition: A type of myopathy associated with mitochondrial disease and characterized by findings on biopsy such as ragged red muscle fibers.
MCID: MC00063357
PMOID: PMO:00009755
Subclass_of: Muscle abnormality related to mitochondrial dysfunction
Synonym: MITOCHONDRIAL MYOPATHY
Synonym: MYOPATHY MITOCHONDRIAL
Synonym: MYOPATHY, MITOCHONDRIAL
Synonym: Mitochondrial Myopathies
Synonym: Mitochondrial Myopathies [Disease/Finding]
Synonym: Mitochondrial Myopathy
Synonym: Mitochondrial cytopathy
Synonym: Mitochondrial myopathy (disorder)
Synonym: Myopathies, Mitochondrial
Synonym: Ragged red myopathy
Tree Number: T3.17.15.3
database_cross_reference: CCPSS:0046266
database_cross_reference: CHV:0000017938
database_cross_reference: CSP:5000-0048
database_cross_reference: DO:DOID:699
database_cross_reference: HPO:HP:0003737
database_cross_reference: MDR:10027710
database_cross_reference: MEDCIN:337551
database_cross_reference: MSH:D017240
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101328
database_cross_reference: NCI_NICHD:C101328
database_cross_reference: NDFRT:N0000003559
database_cross_reference: OMIM:251900
database_cross_reference: OMIM:590000
database_cross_reference: OMIM:590055
database_cross_reference: OMIM:590065
database_cross_reference: OMIM:590095
database_cross_reference: OMIM:MTHU005171
database_cross_reference: RCD:X709I
database_cross_reference: SNM:D-8077
database_cross_reference: SNMI:DA-51600
database_cross_reference: SNOMEDCT_US:16851005
database_cross_reference: SNOMEDCT_US:240096000

Subsarcolemmal accumulations of abnormally shaped mitochondria
type: Class
subclass of: Muscle abnormality related to mitochondrial dysfunction
Definition: An abnormally increased number of mitochondria in the cytoplasma adjacent to the sarcolemma (muscle cell membrane), whereby the mitochondria also possess an abnormal morphology.
MCID: MC01002934
PMOID: PMO:00009757
Subclass_of: Muscle abnormality related to mitochondrial dysfunction
Tree Number: T3.17.15.4
database_cross_reference: HPO:HP:0003548

Muscle haemorrhage
type: Class
subclass of: Abnormality of the musculature
Definition: Haemorrhage occurring within a muscle
MCID: MC00058198
PMOID: PMO:00009758
Subclass_of: Abnormality of the musculature
Synonym: HEMORRHAGE MUSCLE
Synonym: Haemorrhage muscle
Synonym: Haemorrhage of muscle
Synonym: Haemorrhage of muscle, NOS
Synonym: Hemorrhage muscle
Synonym: Hemorrhage of muscle
Synonym: Hemorrhage of muscle (disorder)
Synonym: Hemorrhage of muscle, NOS
Synonym: MUSCLE HAEMORRHAGE
Synonym: MUSCLE HEMORRHAGE
Tree Number: T3.17.16
database_cross_reference: CST:HEM MUSCLE
database_cross_reference: HPO:HP:0040242
database_cross_reference: MDR:10019560
database_cross_reference: MDR:10028309
database_cross_reference: MDR:10028310
database_cross_reference: MDR:10055824
database_cross_reference: MDR:10071842
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:D1-50850
database_cross_reference: SNOMEDCT_US:95422003

Abnormality of the nervous system
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the nervous system.
MCID: MC00157141
PMOID: PMO:00009759
Subclass_of: Phenotypic Abnormality
Synonym: 4-90 CONGENITAL ANOMALIES OF THE NERVOUS SYSTEM: GENERAL TERMS
Synonym: ABNORM CONGEN NERVOUS SYSTEM
Synonym: ABNORM NERVOUS SYSTEM
Synonym: Abnormalities, Congenital, Nervous System
Synonym: Abnormalities, Nervous System
Synonym: Abnormality, Nervous System
Synonym: Anomalies, Nervous System
Synonym: Anomaly, Nervous System
Synonym: CONGEN ABNORM NERVOUS SYSTEM
Synonym: CONGEN ANOMALIES NERVOUS SYSTEM
Tree Number: T3.18
database_cross_reference: AOD:0000006232
database_cross_reference: CSP:0725-4145
database_cross_reference: HPO:HP:0000707
database_cross_reference: ICD10:Q00-Q07.9
database_cross_reference: ICD10:Q07.9
database_cross_reference: ICD10AM:Q00-Q07.9
database_cross_reference: ICD10AM:Q07.9
database_cross_reference: ICD10CM:Q00-Q07
database_cross_reference: ICD10CM:Q07.9
database_cross_reference: ICD9CM:742.9
database_cross_reference: ICPC2EENG:N85
database_cross_reference: ICPC2P:N85004
database_cross_reference: LCH_NW:sh85090918
database_cross_reference: MDR:10045694
database_cross_reference: MEDCIN:335155
database_cross_reference: MSH:D009421
database_cross_reference: MTH:U001554
database_cross_reference: MTHICD9:742.9
database_cross_reference: NCI:C97172
database_cross_reference: NCI_NICHD:C97172
database_cross_reference: NDFRT:N0000002158
database_cross_reference: RCD:P2y..
database_cross_reference: RCD:P2yz.
database_cross_reference: RCD:P2z..
database_cross_reference: RCD:Pyu0.
database_cross_reference: RCD:X00Ef
database_cross_reference: RCDSY:Pyu0.
database_cross_reference: SNMI:D4-90000
database_cross_reference: SNOMEDCT_US:204093003
database_cross_reference: SNOMEDCT_US:204096006
database_cross_reference: SNOMEDCT_US:204097002
database_cross_reference: SNOMEDCT_US:205845004
database_cross_reference: SNOMEDCT_US:88425004

Abnormality of ganglion
type: Class
subclass of: Abnormality of the nervous system
Definition: An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system.
MCID: MC01019131
PMOID: PMO:00009760
Subclass_of: Abnormality of the nervous system
Tree Number: T3.18.1
database_cross_reference: HPO:HP:0410014

Abnormality of cranial ganglion
type: Class
subclass of: Abnormality of ganglion
Definition: An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system of the cranium.
MCID: MC01019133
PMOID: PMO:00009761
Subclass_of: Abnormality of ganglion
Tree Number: T3.18.1.1
database_cross_reference: HPO:HP:0410016

Abnormality of ganglion of peripheral nervous system
type: Class
subclass of: Abnormality of ganglion
Definition: An abnormality of nerve cell cluster or a group of nerve cell bodies located in the peripheral autonomic nervous system.
MCID: MC01019132
PMOID: PMO:00009763
Subclass_of: Abnormality of ganglion
Tree Number: T3.18.1.2
database_cross_reference: HPO:HP:0410015

Abnormality of nervous system morphology
type: Class
subclass of: Abnormality of the nervous system
Definition: A structural anomaly of the nervous system.
MCID: MC01001058
PMOID: PMO:00009764
Subclass_of: Abnormality of the nervous system
Synonym: Abnormal shape of nervous system
Tree Number: T3.18.2
database_cross_reference: HPO:HP:0012639

Abnormal myelination
type: Class
subclass of: Abnormality of nervous system morphology
Definition: Any anomaly in the process by which myelin sheaths are formed and maintained around neurons.
MCID: MC01396019
PMOID: PMO:00009765
Subclass_of: Abnormality of nervous system morphology
Tree Number: T3.18.2.1
database_cross_reference: HPO:HP:0012447

Abnormal neuron morphology
type: Class
subclass of: Abnormality of nervous system morphology
Definition: A structural anomaly of a neuron.
MCID: MC01001031
PMOID: PMO:00009794
Subclass_of: Abnormality of nervous system morphology
Synonym: Abnormal neuron shape
Tree Number: T3.18.2.2
database_cross_reference: HPO:HP:0012757

Abnormal peripheral nervous system morphology
type: Class
subclass of: Abnormality of nervous system morphology
Definition: An abnormality of the peripheral nervous system, which is composed of the nerves that lead to or branch off from the central nervous system. This includes the cranial nerves (olfactory and optic nerves are technically part of the central nervous system).
MCID: MC01003092
PMOID: PMO:00009802
Subclass_of: Abnormality of nervous system morphology
Tree Number: T3.18.2.3
database_cross_reference: HPO:HP:0000759

Morphological abnormality of the central nervous system
type: Class
subclass of: Abnormality of nervous system morphology
Definition: A structural abnormality of the central nervous system.
MCID: MC01000319
PMOID: PMO:00009896
Subclass_of: Abnormality of nervous system morphology
Synonym: Abnormality of the central nervous system
Tree Number: T3.18.2.4
database_cross_reference: HPO:HP:0002011

Neoplasm of the nervous system
type: Class
subclass of: Abnormality of nervous system morphology
Definition: A tumor (abnormal growth of tissue) of the nervous system.
MCID: MC00008793
PMOID: PMO:00010524
Subclass_of: Abnormality of nervous system morphology
Synonym: NEOPL NERVOUS SYSTEM
Synonym: NERVOUS SYSTEM NEOPL
Synonym: Neoplasia of the nervous system
Synonym: Neoplasm of Nervous System
Synonym: Neoplasm of nervous system
Synonym: Neoplasm of nervous system (disorder)
Synonym: Neoplasm of the Nervous System
Synonym: Neoplasm, Nervous System
Synonym: Neoplasms, Nervous System
Synonym: Nervous System Neoplasm
Tree Number: T3.18.2.5
database_cross_reference: AOD:0000004643
database_cross_reference: AOD:0000023105
database_cross_reference: CHV:0000008607
database_cross_reference: CHV:0000049245
database_cross_reference: CSP:2012-5157
database_cross_reference: HPO:HP:0004375
database_cross_reference: LCH_NW:sh00008550
database_cross_reference: LCH_NW:sh85090936
database_cross_reference: MDR:10029208
database_cross_reference: MDR:10061311
database_cross_reference: MSH:D009423
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3268
database_cross_reference: NCI_NICHD:C3268
database_cross_reference: NDFRT:N0000002160
database_cross_reference: PSY:33550
database_cross_reference: RCD:X78Zk
database_cross_reference: RCDAE:X78Zk
database_cross_reference: SNOMEDCT_US:126950007

Abnormality of nervous system physiology
type: Class
subclass of: Abnormality of the nervous system
Definition: A functional anomaly of the nervous system.
MCID: MC01001059
PMOID: PMO:00010546
Subclass_of: Abnormality of the nervous system
Tree Number: T3.18.3
database_cross_reference: HPO:HP:0012638

Abnormal brain positron emission tomography
type: Class
subclass of: Abnormality of nervous system physiology
Definition: A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain.
MCID: MC01001053
PMOID: PMO:00010547
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.1
database_cross_reference: HPO:HP:0012657

Abnormal cranial nerve physiology
type: Class
subclass of: Abnormality of nervous system physiology
Definition: A functional abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem.
MCID: MC01395843
PMOID: PMO:00010553
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.2
database_cross_reference: HPO:HP:0031910

Abnormal metabolic brain imaging by MRS
type: Class
subclass of: Abnormality of nervous system physiology
Definition: An anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS).
MCID: MC01395995
PMOID: PMO:00010560
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.3
database_cross_reference: HPO:HP:0012705

Abnormal nervous system electrophysiology
type: Class
subclass of: Abnormality of nervous system physiology
Definition: An abnormality of the function of the electrical signals with which nerve cells communicate with each other or with muscles as measured by electrophysiological investigations.
MCID: MC01000332
PMOID: PMO:00010578
Subclass_of: Abnormality of nervous system physiology
Synonym: Neurophysiologic abnormalities
Synonym: Neurophysiologic abnormality
Tree Number: T3.18.3.4
database_cross_reference: HPO:HP:0001311

Abnormal synaptic transmission
type: Class
subclass of: Abnormality of nervous system physiology
Definition: An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process.
MCID: MC00999819
PMOID: PMO:00010683
Subclass_of: Abnormality of nervous system physiology
Synonym: Abnormality of neurotransmitter metabolism
Tree Number: T3.18.3.5
database_cross_reference: HPO:HP:0012535

Abnormality of central motor function
type: Class
subclass of: Abnormality of nervous system physiology
Definition: An anomaly of the control or production of movement in the central nervous system.
MCID: MC01001399
PMOID: PMO:00010701
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.6
database_cross_reference: HPO:HP:0011442

Abnormality of central sensory function
type: Class
subclass of: Abnormality of nervous system physiology
Definition: An abnormality of cortical sensation. Assuming the primary sensory modalities are intact and the patient is alert and cooperative, the presence of an abnormality of sensory function usually indicates a lesion of a parietal cortex or of the thalamocortical projections to the parietal cortex.
MCID: MC01001280
PMOID: PMO:00010799
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.7
database_cross_reference: HPO:HP:0011730

Abnormality of higher mental function
type: Class
subclass of: Abnormality of nervous system physiology
Definition: Cognitive, psychiatric or memory anomaly.
MCID: MC01001398
PMOID: PMO:00010804
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.8
database_cross_reference: HPO:HP:0011446

Abnormality of intracranial pressure
type: Class
subclass of: Abnormality of nervous system physiology
Definition: A deviation from the norm of the intracranial pressure.
MCID: MC01001057
PMOID: PMO:00010869
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.9
database_cross_reference: HPO:HP:0012640

Abnormality of movement
type: Class
subclass of: Abnormality of nervous system physiology
Definition: An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements.
MCID: MC00008439
PMOID: PMO:00010872
Subclass_of: Abnormality of nervous system physiology
Synonym: DYSKINESIA SYNDROME
Synonym: Dyskinesia Syndrome
Synonym: Dyskinesia Syndromes
Synonym: Dyskinesia syndrome
Synonym: MOVEMENT DIS
Synonym: MOVEMENT DIS SYNDROMES
Synonym: MOVEMENT DISORDER
Synonym: MOVEMENT DISORDER (NOS)
Synonym: MOVEMENT DISORDERS
Synonym: Movement Disorder
Tree Number: T3.18.3.10
database_cross_reference: CCPSS:0042860
database_cross_reference: CHV:0000008293
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3596
database_cross_reference: CSP:2057-3603
database_cross_reference: CST:DYSKINESIA
database_cross_reference: CST:MOVEMENT DIS
database_cross_reference: CST:NERMOVE
database_cross_reference: DO:DOID:480
database_cross_reference: HPO:HP:0100022
database_cross_reference: LCH:U003043
database_cross_reference: LCH_NW:sh85088017
database_cross_reference: MDR:10013927
database_cross_reference: MDR:10028035
database_cross_reference: MDR:10028036
database_cross_reference: MDR:10028040
database_cross_reference: MDR:10048523
database_cross_reference: MEDCIN:276423
database_cross_reference: MEDLINEPLUS:520
database_cross_reference: MSH:D009069
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C116757
database_cross_reference: NCI_NICHD:C116757
database_cross_reference: NDFRT:N0000002039
database_cross_reference: OMIM:MTHU006688
database_cross_reference: OMIM:MTHU044333
database_cross_reference: PSY:32375
database_cross_reference: SNMI:DA-21100
database_cross_reference: SNOMEDCT_US:60342002

Behavioral abnormality
type: Class
subclass of: Abnormality of nervous system physiology
Definition: An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities.
MCID: MC00078958
PMOID: PMO:00011040
Subclass_of: Abnormality of nervous system physiology
Synonym: Abnormal Behavior
Synonym: Abnormal behavior
Synonym: Abnormal behavior (finding)
Synonym: Abnormal behavior NOS
Synonym: Abnormal behavior, NOS
Synonym: Abnormal behaviour
Synonym: Abnormal behaviour NOS
Synonym: Abnormal conduct
Synonym: Abnormal conduct, NOS
Synonym: BEHAVIOR ABNORMAL
Tree Number: T3.18.3.11
database_cross_reference: AOD:0000006422
database_cross_reference: AOD:0000023690
database_cross_reference: CCPSS:0063207
database_cross_reference: CHV:0000023127
database_cross_reference: CHV:0000025345
database_cross_reference: CHV:0000025346
database_cross_reference: COSTAR:U000067
database_cross_reference: COSTAR:U000068
database_cross_reference: CST:PERSON DIS
database_cross_reference: HPO:HP:0000708
database_cross_reference: MDR:10000118
database_cross_reference: MDR:10004203
database_cross_reference: MDR:10004206
database_cross_reference: MDR:10061422
database_cross_reference: MEDCIN:112189
database_cross_reference: MSH:D000066553
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C122430
database_cross_reference: NCI_NICHD:C122430
database_cross_reference: OMIM:MTHU000244
database_cross_reference: OMIM:MTHU007827
database_cross_reference: OMIM:MTHU008026
database_cross_reference: OMIM:MTHU012413
database_cross_reference: OMIM:MTHU030536
database_cross_reference: OMIM:MTHU051770
database_cross_reference: OMIM:MTHU053441
database_cross_reference: PSY:05650
database_cross_reference: RCD:Xa0Xh
database_cross_reference: RCDAE:Xa0Xh
database_cross_reference: SNM:F-91010
database_cross_reference: SNM:F-94010
database_cross_reference: SNMI:F-93010
database_cross_reference: SNOMEDCT_US:25786006
database_cross_reference: SNOMEDCT_US:277843001

Bulbar palsy
type: Class
subclass of: Abnormality of nervous system physiology
Definition: Bulbar weakness (or bulbar palsy) refers to bilateral impairment of function of the lower cranial nerves IX, X, XI and XII, which occurs due to lower motor neuron lesion either at nuclear or fascicular level in the medulla or from bilateral lesions of the lower cranial nerves outside the brain-stem. Bulbar weakness is often associated with difficulty in chewing, weakness of the facial muscles, dysarthria, palatal weakness and regurgitation of fluids, dysphagia, and dysphonia.
MCID: MC00009706
PMOID: PMO:00011190
Subclass_of: Abnormality of nervous system physiology
Synonym: Bulbar Palsies, Progressive
Synonym: Bulbar Palsy, Progressive
Synonym: Bulbar Palsy, Progressive [Disease/Finding]
Synonym: Bulbar paralysis
Synonym: PBP - Progressive bulbar palsy
Synonym: Palsies, Progressive Bulbar
Synonym: Palsy, Progressive Bulbar
Synonym: Progressive Bulbar Palsies
Synonym: Progressive Bulbar Palsy
Synonym: Progressive bulbar palsy
Tree Number: T3.18.3.12
database_cross_reference: CHV:0000009270
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3603
database_cross_reference: DO:DOID:681
database_cross_reference: ICD10CM:G12.22
database_cross_reference: ICD9CM:335.22
database_cross_reference: MDR:10036800
database_cross_reference: MEDCIN:36392
database_cross_reference: MSH:D010244
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85026
database_cross_reference: NDFRT:N0000002304
database_cross_reference: RCD:F1522
database_cross_reference: SNM:D-8143
database_cross_reference: SNMI:DA-23030
database_cross_reference: SNOMEDCT_US:54304004

Bulbar signs
type: Class
subclass of: Abnormality of nervous system physiology
MCID: MC01397187
PMOID: PMO:00011191
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.13
database_cross_reference: HPO:HP:0002483

Cataplexy
type: Class
subclass of: Abnormality of nervous system physiology
Definition: A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions.
MCID: MC00002368
PMOID: PMO:00011192
Subclass_of: Abnormality of nervous system physiology
Synonym: Attack, Cataleptic
Synonym: Attacks, Cataleptic
Synonym: CATAPLEXY
Synonym: Cataleptic Attack
Synonym: Cataleptic Attacks
Synonym: Cataplexy (diagnosis)
Synonym: Cataplexy (disorder)
Synonym: Cataplexy [Disease/Finding]
Synonym: Henneberg Syndrome
Synonym: Syndrome, Henneberg
Tree Number: T3.18.3.14
database_cross_reference: CCPSS:1002072
database_cross_reference: CHV:0000002517
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3270
database_cross_reference: CST:CONVULS
database_cross_reference: DXP:U000304
database_cross_reference: DXP:U000571
database_cross_reference: HPO:HP:0002524
database_cross_reference: MDR:10007737
database_cross_reference: MEDCIN:359464
database_cross_reference: MSH:D002385
database_cross_reference: NCI:C84618
database_cross_reference: NDFRT:N0000000697
database_cross_reference: OMIM:161400
database_cross_reference: OMIM:MTHU003011
database_cross_reference: PSY:07880
database_cross_reference: RCD:F270.
database_cross_reference: SNM:F-85770
database_cross_reference: SNMI:D9-74260
database_cross_reference: SNOMEDCT_US:46263000

Dysphagia
type: Class
subclass of: Abnormality of nervous system physiology
Definition: Difficulty in swallowing.
MCID: MC00003585
PMOID: PMO:00011193
Subclass_of: Abnormality of nervous system physiology
Synonym: Can't get food down
Synonym: Cannot get food down
Synonym: DEGLUTITION DIS
Synonym: DEGLUTITION DISORDER
Synonym: DISORDER DEGLUTITION
Synonym: DYSPHAGIA
Synonym: Deglutition Disorder
Synonym: Deglutition Disorders
Synonym: Deglutition Disorders [Disease/Finding]
Synonym: Deglutition disorder
Tree Number: T3.18.3.15
database_cross_reference: AOD:0000005507
database_cross_reference: BI:BI00239
database_cross_reference: CCPSS:1014574
database_cross_reference: CHV:0000003662
database_cross_reference: COSTAR:265
database_cross_reference: CSP:5000-0052
database_cross_reference: CST:DYSPHAGIA
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001012
database_cross_reference: HPO:HP:0002015
database_cross_reference: HPO:HP:0200136
database_cross_reference: ICD10:R13
database_cross_reference: ICD10AM:R13
database_cross_reference: ICD10CM:R13.1
database_cross_reference: ICD10CM:R13.10
database_cross_reference: ICD9CM:787.2
database_cross_reference: ICD9CM:787.20
database_cross_reference: ICPC2P:D21003
database_cross_reference: ICPC2P:D21004
database_cross_reference: LCH_NW:sh85036477
database_cross_reference: LNC:MTHU029874
database_cross_reference: MDR:10012173
database_cross_reference: MDR:10013213
database_cross_reference: MDR:10013950
database_cross_reference: MDR:10042645
database_cross_reference: MDR:10042646
database_cross_reference: MEDCIN:312702
database_cross_reference: MEDCIN:399
database_cross_reference: MEDLINEPLUS:1309
database_cross_reference: MSH:D003680
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:787.20
database_cross_reference: NCI:C2980
database_cross_reference: NCI_CTCAE:E10621
database_cross_reference: NCI_FDA:1815
database_cross_reference: NCI_NCI-GLOSS:CDR0000044666
database_cross_reference: NCI_NICHD:C2980
database_cross_reference: NDFRT:N0000000910
database_cross_reference: OMIM:MTHU036443
database_cross_reference: OMIM:MTHU036956
database_cross_reference: OMIM:MTHU037360
database_cross_reference: OMIM:MTHU037782
database_cross_reference: OMIM:MTHU038534
database_cross_reference: OMIM:MTHU056733
database_cross_reference: PDQ:CDR0000524080
database_cross_reference: PSY:15654
database_cross_reference: RCD:R072.
database_cross_reference: RCD:R0720
database_cross_reference: RCD:R072z
database_cross_reference: RCD:XM08J
database_cross_reference: RCD:Xa4JZ
database_cross_reference: RCDSY:R072.
database_cross_reference: RCDSY:R0720
database_cross_reference: RCDSY:R072z
database_cross_reference: SNM:F-61020
database_cross_reference: SNMI:D5-30250
database_cross_reference: SNOMEDCT_US:139289002
database_cross_reference: SNOMEDCT_US:158429003
database_cross_reference: SNOMEDCT_US:158430008
database_cross_reference: SNOMEDCT_US:158431007
database_cross_reference: SNOMEDCT_US:162022009
database_cross_reference: SNOMEDCT_US:207121004
database_cross_reference: SNOMEDCT_US:207122006

Easy fatigability
type: Class
subclass of: Abnormality of nervous system physiology
Definition: Increased susceptibility to fatigue.
MCID: MC01397945
PMOID: PMO:00011197
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.16
database_cross_reference: HPO:HP:0003388

Encephalopathy
type: Class
subclass of: Abnormality of nervous system physiology
Definition: Encephalopathy is a term that means brain disease, damage, or malfunction. In general, encephalopathy is manifested by an altered mental state.
MCID: MC00001917
PMOID: PMO:00011198
Subclass_of: Abnormality of nervous system physiology
Synonym: BRAIN DIS
Synonym: BRAIN DISORDER (NOS)
Synonym: Brain
Synonym: Brain Disease
Synonym: Brain Diseases
Synonym: Brain Diseases [Disease/Finding]
Synonym: Brain Disorder
Synonym: Brain Disorders
Synonym: Brain condition NOS
Synonym: Brain conditions NOS
Tree Number: T3.18.3.17
database_cross_reference: CHV:0000002134
database_cross_reference: CHV:0000032204
database_cross_reference: CSP:0485-0499
database_cross_reference: CST:BRAIN SYND ACUTE
database_cross_reference: CST:NER/CNS/B
database_cross_reference: DO:DOID:936
database_cross_reference: ICD10:G93.9
database_cross_reference: ICD10AM:G93.9
database_cross_reference: ICD10CM:G93.9
database_cross_reference: ICD9CM:348.9
database_cross_reference: LCH_NW:sh85016332
database_cross_reference: MDR:10006119
database_cross_reference: MDR:10006120
database_cross_reference: MDR:10045690
database_cross_reference: MEDCIN:210110
database_cross_reference: MEDCIN:337652
database_cross_reference: MEDLINEPLUS:174
database_cross_reference: MSH:D001927
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C96413
database_cross_reference: NCI_NICHD:C96413
database_cross_reference: NDFRT:N0000000605
database_cross_reference: PSY:06800
database_cross_reference: RCD:F28z.
database_cross_reference: SNMI:DA-00010
database_cross_reference: SNOMEDCT_US:193059005
database_cross_reference: SNOMEDCT_US:81308009

Headache
type: Class
subclass of: Abnormality of nervous system physiology
Definition: Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
MCID: MC00005965
PMOID: PMO:00011213
Subclass_of: Abnormality of nervous system physiology
Synonym: CEPHALALGIA
Synonym: CEPHALGIA
Synonym: Cephalalgia
Synonym: Cephalalgias
Synonym: Cephalgia
Synonym: Cephalgias
Synonym: Cephalodynia
Synonym: Cephalodynias
Synonym: Cranial Pain
Synonym: Cranial Pains
Tree Number: T3.18.3.18
database_cross_reference: AOD:0000006115
database_cross_reference: AOD:0000006116
database_cross_reference: AOD:0000006117
database_cross_reference: BI:BI00020
database_cross_reference: CCPSS:1014497
database_cross_reference: CCPSS:U001223
database_cross_reference: CHV:0000005820
database_cross_reference: COSTAR:343
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2056-6161
database_cross_reference: CST:HEADACHE
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001858
database_cross_reference: HPO:HP:0002315
database_cross_reference: ICD10:R51
database_cross_reference: ICD10AM:R51
database_cross_reference: ICD10CM:R51
database_cross_reference: ICD9CM:784.0
database_cross_reference: ICPC2EENG:N01
database_cross_reference: ICPC2P:N01001
database_cross_reference: ICPC2P:N01004
database_cross_reference: LCH:U002088
database_cross_reference: LCH_NW:sh85059488
database_cross_reference: LNC:LA15854-5
database_cross_reference: LNC:LA15903-0
database_cross_reference: LNC:LP217220-5
database_cross_reference: LNC:MTHU020860
database_cross_reference: LNC:MTHU053651
database_cross_reference: MDR:10008011
database_cross_reference: MDR:10008013
database_cross_reference: MDR:10019198
database_cross_reference: MDR:10019211
database_cross_reference: MDR:10019218
database_cross_reference: MDR:10019231
database_cross_reference: MDR:10033405
database_cross_reference: MEDCIN:10
database_cross_reference: MEDLINEPLUS:273
database_cross_reference: MSH:D006261
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:784.0
database_cross_reference: NCI:C34661
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CTCAE:E12678
database_cross_reference: NCI_FDA:1880
database_cross_reference: NCI_NICHD:C34661
database_cross_reference: NDFRT:N0000001418
database_cross_reference: OMIM:MTHU036348
database_cross_reference: OMIM:MTHU036635
database_cross_reference: PSY:22380
database_cross_reference: RCD:R040.
database_cross_reference: RCD:XE0rh
database_cross_reference: RCD:XE2rs
database_cross_reference: RCDSY:R040.
database_cross_reference: RCDSY:XE2rs
database_cross_reference: SNM:F-82700
database_cross_reference: SNMI:F-A2700
database_cross_reference: SNOMEDCT_US:139490008
database_cross_reference: SNOMEDCT_US:158296002
database_cross_reference: SNOMEDCT_US:158298001
database_cross_reference: SNOMEDCT_US:162209005
database_cross_reference: SNOMEDCT_US:206946005
database_cross_reference: SNOMEDCT_US:206948006

Hypocalcemic tetany
type: Class
subclass of: Abnormality of nervous system physiology
Definition: Hyperexcitability of the neuromuscular system related to abnormally low level of calcium in the blood, resulting in carpopedal or generalized spasms.
MCID: MC00058271
PMOID: PMO:00011223
Subclass_of: Abnormality of nervous system physiology
Synonym: HYPOCALCEMIC TETANY
Synonym: Hypocalcaemic tetany
Synonym: Hypocalcemic tetany (disorder)
Synonym: TETANY HYPOCALCEMIC
Synonym: Tetany hypocalcaemic
Synonym: Tetany hypocalcemic
Tree Number: T3.18.3.19
database_cross_reference: CST:TETANY HYPOCALCEM
database_cross_reference: HPO:HP:0003472
database_cross_reference: MDR:10020951
database_cross_reference: MDR:10043381
database_cross_reference: MDR:10060381
database_cross_reference: MDR:10060425
database_cross_reference: OMIM:MTHU019662
database_cross_reference: RCD:C3546
database_cross_reference: RCDAE:C3546
database_cross_reference: SNOMEDCT_US:190869004

Neurodevelopmental abnormality
type: Class
subclass of: Abnormality of nervous system physiology
Definition: A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities.
MCID: MC01001030
PMOID: PMO:00011224
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.20
database_cross_reference: HPO:HP:0012759

Pseudobulbar signs
type: Class
subclass of: Abnormality of nervous system physiology
Definition: Pseudobulbar signs result from injury to an upper motor neuron lesion to the corticobulbar pathways in the pyramidal tract. Patients have difficulty chewing, swallowing and demonstrate slurred speech (often initial presentation) as well as abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc.
MCID: MC00605116
PMOID: PMO:00011261
Subclass_of: Abnormality of nervous system physiology
Synonym: Pseudobulbar symptoms
Tree Number: T3.18.3.21
database_cross_reference: HPO:HP:0002200
database_cross_reference: OMIM:MTHU006592
database_cross_reference: OMIM:MTHU031656

Seizures
type: Class
subclass of: Abnormality of nervous system physiology
Definition: Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures.
MCID: MC00011711
PMOID: PMO:00011263
Subclass_of: Abnormality of nervous system physiology
Synonym: A70-A72 CONVULSIONS
Synonym: CONVULSION
Synonym: CONVULSION (NOS)
Synonym: CONVULSIONS
Synonym: Convulsion
Synonym: Convulsion (NOS)
Synonym: Convulsion (disorder)
Synonym: Convulsion NOS
Synonym: Convulsion, NOS
Synonym: Convulsions
Tree Number: T3.18.3.22
database_cross_reference: AOD:0000004417
database_cross_reference: BI:BI00559
database_cross_reference: CCPSS:1017690
database_cross_reference: CHV:0000003335
database_cross_reference: CHV:0000011162
database_cross_reference: COSTAR:672
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0485-6986
database_cross_reference: CSP:2057-3348
database_cross_reference: CST:CONVULS
database_cross_reference: DXP:U003487
database_cross_reference: HPO:HP:0001250
database_cross_reference: ICD10CM:R56.9
database_cross_reference: ICD9CM:780.3
database_cross_reference: ICPC2P:N07001
database_cross_reference: ICPC2P:N07002
database_cross_reference: ICPC2P:N07003
database_cross_reference: LCH:U001154
database_cross_reference: LNC:LA15899-0
database_cross_reference: LNC:LA7472-9
database_cross_reference: MDR:10010904
database_cross_reference: MDR:10010906
database_cross_reference: MDR:10010914
database_cross_reference: MDR:10010922
database_cross_reference: MDR:10016731
database_cross_reference: MDR:10016735
database_cross_reference: MDR:10016736
database_cross_reference: MDR:10039906
database_cross_reference: MDR:10039910
database_cross_reference: MEDCIN:658
database_cross_reference: MEDCIN:66036
database_cross_reference: MEDLINEPLUS:396
database_cross_reference: MSH:D012640
database_cross_reference: MTH:673
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.39
database_cross_reference: NCI:C2962
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CTCAE:E12804
database_cross_reference: NCI_FDA:2063
database_cross_reference: NCI_NCI-GLOSS:CDR0000045484
database_cross_reference: NCI_NICHD:C2962
database_cross_reference: NDFRT:N0000002713
database_cross_reference: OMIM:MTHU000242
database_cross_reference: OMIM:MTHU004223
database_cross_reference: PDQ:CDR0000525976
database_cross_reference: PSY:11750
database_cross_reference: PSY:46145
database_cross_reference: RCD:R003.
database_cross_reference: RCD:R0032
database_cross_reference: RCD:R003z
database_cross_reference: RCD:XaDbE
database_cross_reference: RCD:XaEHz
database_cross_reference: RCD:XaEI2
database_cross_reference: RCDSY:R003.
database_cross_reference: RCDSY:R0032
database_cross_reference: RCDSY:R003z
database_cross_reference: SNM:F-87000
database_cross_reference: SNM:U000217
database_cross_reference: SNMI:F-A7000
database_cross_reference: SNMI:F-A7100
database_cross_reference: SNOMEDCT_US:158138006
database_cross_reference: SNOMEDCT_US:158141002

Abnormality of the peripheral nervous system
type: Class
subclass of: Abnormality of the nervous system
Definition: Any abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord.
MCID: MC01396393
PMOID: PMO:00011335
Subclass_of: Abnormality of the nervous system
Tree Number: T3.18.4
database_cross_reference: HPO:HP:0410008

Abnormality of the autonomic nervous system
type: Class
subclass of: Abnormality of the peripheral nervous system
Definition: An abnormality of the autonomic nervous system.
MCID: MC01002994
PMOID: PMO:00011336
Subclass_of: Abnormality of the peripheral nervous system
Tree Number: T3.18.4.1
database_cross_reference: HPO:HP:0002270

Abnormality of the somatic nervous system
type: Class
subclass of: Abnormality of the peripheral nervous system
Definition: Any abnormality of the part of the peripheral nervous system associated with sensation and skeletal muscle voluntary control of body movements.
MCID: MC01019126
PMOID: PMO:00011348
Subclass_of: Abnormality of the peripheral nervous system
Tree Number: T3.18.4.2
database_cross_reference: HPO:HP:0410009

Abnormality of the respiratory system
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles.
MCID: MC00998590
PMOID: PMO:00011354
Subclass_of: Phenotypic Abnormality
Synonym: Respiratory abnormality
Tree Number: T3.19
database_cross_reference: HPO:HP:0002086
database_cross_reference: MTH:NOCODE

Abnormal respiratory system morphology
type: Class
subclass of: Abnormality of the respiratory system
Definition: A structural anomaly of the respiratory system.
MCID: MC01001144
PMOID: PMO:00011355
Subclass_of: Abnormality of the respiratory system
Tree Number: T3.19.1
database_cross_reference: HPO:HP:0012252

Abnormal lung morphology
type: Class
subclass of: Abnormal respiratory system morphology
Definition: Any structural anomaly of the lung.
PMOID: PMO:00011356
Subclass_of: Abnormal respiratory system morphology
Tree Number: T3.19.1.1

Abnormal pulmonary situs morphology
type: Class
subclass of: Abnormal respiratory system morphology
Definition: An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, which is defined by characteristics such as the number of lobes per lung and the relationship of the pulmonary arteries to their bronchi.
PMOID: PMO:00011470
Subclass_of: Abnormal respiratory system morphology
Tree Number: T3.19.1.2

Abnormal respiratory epithelium morphology
type: Class
subclass of: Abnormal respiratory system morphology
Definition: Any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.
MCID: MC01001143
PMOID: PMO:00011475
Subclass_of: Abnormal respiratory system morphology
Tree Number: T3.19.1.3
database_cross_reference: HPO:HP:0012253

Abnormal sputum
type: Class
subclass of: Abnormal respiratory system morphology
Definition: Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin.
MCID: MC01396148
PMOID: PMO:00011490
Subclass_of: Abnormal respiratory system morphology
Synonym: Abnormal sputum morphology
Tree Number: T3.19.1.4
database_cross_reference: HPO:HP:0032016

Abnormality of the upper respiratory tract
type: Class
subclass of: Abnormal respiratory system morphology
Definition: An abnormality of the upper respiratory tract.
MCID: MC01003005
PMOID: PMO:00011493
Subclass_of: Abnormal respiratory system morphology
Tree Number: T3.19.1.5
database_cross_reference: HPO:HP:0002087

Functional respiratory abnormality
type: Class
subclass of: Abnormality of the respiratory system
MCID: MC01398471
PMOID: PMO:00011552
Subclass_of: Abnormality of the respiratory system
Synonym: Abnormal respiration
Tree Number: T3.19.2
database_cross_reference: HPO:HP:0002795

Abnormal blood gas level
type: Class
subclass of: Functional respiratory abnormality
Definition: An abnormality of the partial pressure of oxygen or carbon dioxide in the arterial blood.
MCID: MC01395768
PMOID: PMO:00011553
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.1
database_cross_reference: HPO:HP:0012415

Abnormal breath sound
type: Class
subclass of: Functional respiratory abnormality
Definition: An anomalous (adventitious) sound produced by the breathing process.
MCID: MC01395780
PMOID: PMO:00011559
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.2
database_cross_reference: HPO:HP:0030829

Abnormal bronchus physiology
type: Class
subclass of: Functional respiratory abnormality
Definition: Any anomaly of the function of the bronchi.
MCID: MC01395782
PMOID: PMO:00011574
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.3
database_cross_reference: HPO:HP:0025427

Abnormal mucociliary clearance
type: Class
subclass of: Functional respiratory abnormality
Definition: An anomaly in the system of mucociliary transport, which functions to transport the mucous layer lining the respiratory epithelium by ciliary beating.
MCID: MC01396017
PMOID: PMO:00011576
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal mucociliary transport
Tree Number: T3.19.2.4
database_cross_reference: HPO:HP:0031602

Abnormal nasal mucus secretion
type: Class
subclass of: Functional respiratory abnormality
Definition: Any deviation from the normal quantity of secretion of nasal mucus, a thick viscous liquid produced by the mucous membranes of the nose.
MCID: MC01396022
PMOID: PMO:00011578
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.5
database_cross_reference: HPO:HP:0031416

Abnormal pattern of respiration
type: Class
subclass of: Functional respiratory abnormality
Definition: An anomaly of the rhythm or depth of breathing.
MCID: MC01396048
PMOID: PMO:00011580
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal respiratory patterns
Synonym: Unusual breathing patterns
Tree Number: T3.19.2.6
database_cross_reference: HPO:HP:0002793

Abnormal respiratory motile cilium physiology
type: Class
subclass of: Functional respiratory abnormality
Definition: Any functional anomaly of the respiratory motile cilia.
MCID: MC01001140
PMOID: PMO:00011603
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.7
database_cross_reference: HPO:HP:0012261

Abnormal response to short acting pulmonary vasodilator
type: Class
subclass of: Functional respiratory abnormality
Definition: Pulmonary vasodilator testing is performed during right-heart catheterization and involves a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide. The current definition of a normal (positive) response is a drop in mean pulmonary artery pressure of at least 10 mm Hg (or 20 percent) to below 40 mm Hg.
MCID: MC01062168
PMOID: PMO:00011607
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.8
database_cross_reference: HPO:HP:0030893

Abnormality of pulmonary circulation
type: Class
subclass of: Functional respiratory abnormality
Definition: A functional anomaly of that portion of the cardiosvascular system that carries deoxygenated blood from the heart to the lungs and returns oxygenated blood back to the heart.
MCID: MC01396350
PMOID: PMO:00011609
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal pulmonary circulation
Synonym: Abnormality of respiratory circulation
Tree Number: T3.19.2.9
database_cross_reference: HPO:HP:0030875

Abnormality on pulmonary function testing
type: Class
subclass of: Functional respiratory abnormality
Definition: Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography.
MCID: MC01396437
PMOID: PMO:00011618
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal pulmonary function test
Tree Number: T3.19.2.10
database_cross_reference: HPO:HP:0030878

Aspiration
type: Class
subclass of: Functional respiratory abnormality
Definition: Inspiration of a foreign object into the airway.
MCID: MC00231816
PMOID: PMO:00011623
Subclass_of: Functional respiratory abnormality
Synonym: 292 PULMONARY ASPIRATION
Synonym: ASPIRATION
Synonym: Aspirated
Synonym: Aspiration, NOS
Synonym: PULMONARY ASPIRATION
Synonym: Pulmonary Aspirations
Synonym: Pulmonary aspiration
Synonym: Pulmonary aspiration (diagnosis)
Synonym: Pulmonary aspiration (finding)
Synonym: Pulmonary aspiration, NOS
Tree Number: T3.19.2.11
database_cross_reference: CCPSS:0023485
database_cross_reference: CHV:0000022853
database_cross_reference: CHV:0000044687
database_cross_reference: CST:RESPIRAT DIS
database_cross_reference: DXP:U000268
database_cross_reference: HPO:HP:0002835
database_cross_reference: MDR:10003504
database_cross_reference: MEDCIN:361189
database_cross_reference: MEDCIN:91253
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:F-79000
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:F-29200
database_cross_reference: SNOMEDCT_US:68052005

Asthma
type: Class
subclass of: Functional respiratory abnormality
Definition: Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.
MCID: MC00001329
PMOID: PMO:00011624
Subclass_of: Functional respiratory abnormality
Synonym: -- Asthma
Synonym: 2-51 ASTHMA
Synonym: ASTHMA
Synonym: ASTHMA BRONCHIAL
Synonym: ASTHMA, BRONCHIAL
Synonym: Airway hyperreactivity
Synonym: Asthma (disorder)
Synonym: Asthma (disorder) [Ambiguous]
Synonym: Asthma NOS
Synonym: Asthma NOS (disorder)
Tree Number: T3.19.2.12
database_cross_reference: AOD:0000005951
database_cross_reference: BI:BI00009
database_cross_reference: CCPSS:1017373
database_cross_reference: CHV:0000001541
database_cross_reference: CHV:0000050455
database_cross_reference: COSTAR:080
database_cross_reference: CSP:1525-2157
database_cross_reference: CST:ASTHMA
database_cross_reference: DO:DOID:2841
database_cross_reference: DXP:U000171
database_cross_reference: DXP:U000273
database_cross_reference: HPO:HP:0002099
database_cross_reference: ICD10:J45
database_cross_reference: ICD10:J45.9
database_cross_reference: ICD10AM:J45
database_cross_reference: ICD10AM:J45.9
database_cross_reference: ICD10CM:J45
database_cross_reference: ICD10CM:J45.90
database_cross_reference: ICD10CM:J45.909
database_cross_reference: ICD9CM:493
database_cross_reference: ICD9CM:493.9
database_cross_reference: ICPC2EENG:R96
database_cross_reference: ICPC2P:R96001
database_cross_reference: LCH:U000405
database_cross_reference: LCH_NW:sh85008860
database_cross_reference: LNC:LA10564-5
database_cross_reference: LNC:LA16982-3
database_cross_reference: LNC:MTHU020815
database_cross_reference: MDR:10003553
database_cross_reference: MDR:10003555
database_cross_reference: MDR:10003560
database_cross_reference: MDR:10003561
database_cross_reference: MDR:10003565
database_cross_reference: MDR:10006070
database_cross_reference: MDR:10006450
database_cross_reference: MEDCIN:32881
database_cross_reference: MEDLINEPLUS:2
database_cross_reference: MSH:D001249
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:493.9
database_cross_reference: NCI:C28397
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_FDA:1726
database_cross_reference: NCI_NCI-GLOSS:CDR0000440101
database_cross_reference: NCI_NICHD:C28397
database_cross_reference: NDFRT:N0000000498
database_cross_reference: OMIM:MTHU003537
database_cross_reference: OMIM:MTHU005153
database_cross_reference: PSY:04190
database_cross_reference: RCD:H33..
database_cross_reference: RCD:H33z.
database_cross_reference: RCD:XE0YX
database_cross_reference: SNM:D-4790
database_cross_reference: SNMI:D2-51000
database_cross_reference: SNOMEDCT_US:155574008
database_cross_reference: SNOMEDCT_US:155579003
database_cross_reference: SNOMEDCT_US:187687003
database_cross_reference: SNOMEDCT_US:195967001
database_cross_reference: SNOMEDCT_US:195979001
database_cross_reference: SNOMEDCT_US:195983001
database_cross_reference: SNOMEDCT_US:21341004
database_cross_reference: SNOMEDCT_US:266365004

Breathing dysregulation
type: Class
subclass of: Functional respiratory abnormality
MCID: MC01397130
PMOID: PMO:00011628
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal breathing
Synonym: Breathing difficulty
Synonym: Difficult to breathe
Tree Number: T3.19.2.13
database_cross_reference: HPO:HP:0005957

Cough
type: Class
subclass of: Functional respiratory abnormality
Definition: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
MCID: MC00003303
PMOID: PMO:00011631
Subclass_of: Functional respiratory abnormality
Synonym: 241 COUGHS
Synonym: C/O - cough
Synonym: C/O - cough (context-dependent category)
Synonym: COUGH
Synonym: COUGHING
Synonym: COUGHS
Synonym: Complaining of cough
Synonym: Complaining of cough (finding)
Synonym: Cough (finding)
Synonym: Cough [Disease/Finding]
Tree Number: T3.19.2.14
database_cross_reference: AOD:0000000620
database_cross_reference: BI:BI00179
database_cross_reference: CCPSS:1017295
database_cross_reference: CHV:0000003404
database_cross_reference: CHV:0000033491
database_cross_reference: COSTAR:212
database_cross_reference: CSP:2616-8354
database_cross_reference: CST:COUGH INC
database_cross_reference: DRUGBANK:DB00316
database_cross_reference: DRUGBANK:DB00366
database_cross_reference: DRUGBANK:DB00514
database_cross_reference: DRUGBANK:DB00874
database_cross_reference: DXP:U000880
database_cross_reference: HPO:HP:0012735
database_cross_reference: ICD10:R05
database_cross_reference: ICD10AM:R05
database_cross_reference: ICD10CM:R05
database_cross_reference: ICD9CM:786.2
database_cross_reference: ICPC2EENG:R05
database_cross_reference: ICPC2P:R05004
database_cross_reference: LCH:U001180
database_cross_reference: LCH_NW:sh85033394
database_cross_reference: MDR:10011224
database_cross_reference: MDR:10011232
database_cross_reference: MEDCIN:247
database_cross_reference: MEDLINEPLUS:1543
database_cross_reference: MSH:D003371
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C37935
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CTCAE:E13364
database_cross_reference: NCI_NICHD:C37935
database_cross_reference: NDFRT:N0000000863
database_cross_reference: OMIM:MTHU015709
database_cross_reference: RCD:171Z.
database_cross_reference: RCD:R062.
database_cross_reference: RCD:XC07I
database_cross_reference: RCD:XE0qn
database_cross_reference: RCD:XM0Ch
database_cross_reference: RCD:Xa7u8
database_cross_reference: RCDSY:R062.
database_cross_reference: SNM:F-75860
database_cross_reference: SNMI:F-24100
database_cross_reference: SNOMEDCT_US:139176003
database_cross_reference: SNOMEDCT_US:139190000
database_cross_reference: SNOMEDCT_US:158383001
database_cross_reference: SNOMEDCT_US:161921002
database_cross_reference: SNOMEDCT_US:161935000
database_cross_reference: SNOMEDCT_US:207066005
database_cross_reference: SNOMEDCT_US:263731006
database_cross_reference: SNOMEDCT_US:272039006
database_cross_reference: SNOMEDCT_US:301235001
database_cross_reference: SNOMEDCT_US:49727002
database_cross_reference: SNOMEDCT_VET:49727002

Decreased pulmonary function
type: Class
subclass of: Functional respiratory abnormality
MCID: MC00079910
PMOID: PMO:00011635
Subclass_of: Functional respiratory abnormality
Synonym: DEPRESSION RESPIRATORY
Synonym: Decreased lung function
Synonym: Decreased respiration
Synonym: Decreased respiratory function
Synonym: Decreased respiratory function (finding)
Synonym: Depression respiratory
Synonym: Depressions, Ventilatory
Synonym: FUNCTION PULMONARY DECREASED
Synonym: Function pulmonary decreased
Synonym: LUNG FUNCTION DECREASED
Tree Number: T3.19.2.15
database_cross_reference: CCPSS:0017150
database_cross_reference: CCPSS:1016342
database_cross_reference: CHV:0000022793
database_cross_reference: CHV:0000023445
database_cross_reference: CST:HYPOVENTIL
database_cross_reference: CST:LUNG FUNC DEC
database_cross_reference: HPO:HP:0002791
database_cross_reference: HPO:HP:0005952
database_cross_reference: MDR:10012396
database_cross_reference: MDR:10017477
database_cross_reference: MDR:10025093
database_cross_reference: MDR:10025094
database_cross_reference: MDR:10038650
database_cross_reference: MDR:10038678
database_cross_reference: MSH:D012131
database_cross_reference: NCI:C116314
database_cross_reference: NCI_NICHD:C116314
database_cross_reference: SNM:F-75004
database_cross_reference: SNMI:F-20004
database_cross_reference: SNOMEDCT_US:80954004

Dyspnea
type: Class
subclass of: Functional respiratory abnormality
Definition: Difficult or labored breathing.
MCID: MC00004249
PMOID: PMO:00011637
Subclass_of: Functional respiratory abnormality
Synonym: (Symptom: [SOB] or [breathlessness] or [dyspnea]) or (breathlessness)
Synonym: (Symptom: [SOB] or [breathlessness] or [dyspnoea]) or (breathlessness)
Synonym: (Symptom: [SOB] or [breathlessness] or [dyspnoea]) or (breathlessness) (finding)
Synonym: BREATH SHORTNESS
Synonym: BREATHING DIFFICULT
Synonym: BREATHLESSNESS
Synonym: Breath Shortness
Synonym: Breath Shortnesses
Synonym: Breath shortness
Synonym: Breathing Difficulties
Tree Number: T3.19.2.16
database_cross_reference: AOD:0000005442
database_cross_reference: BI:BI00181
database_cross_reference: BI:BI00182
database_cross_reference: CCPSS:1011301
database_cross_reference: CCPSS:1015304
database_cross_reference: CCPSS:1017161
database_cross_reference: CHV:0000004216
database_cross_reference: CHV:0000032132
database_cross_reference: COSTAR:266
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2596-2296
database_cross_reference: CST:DYSPNEA
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001014
database_cross_reference: HPO:HP:0002094
database_cross_reference: HPO:HP:0002880
database_cross_reference: ICD10:R06.0
database_cross_reference: ICD10AM:R06.0
database_cross_reference: ICD10AMAE:R06.0
database_cross_reference: ICD10CM:R06.0
database_cross_reference: ICD10CM:R06.00
database_cross_reference: ICD10CM:R06.02
database_cross_reference: ICD9CM:786.05
database_cross_reference: ICPC2EENG:R02
database_cross_reference: ICPC2P:R02001
database_cross_reference: ICPC2P:R02002
database_cross_reference: ICPC2P:R02004
database_cross_reference: ICPC2P:R02007
database_cross_reference: LCH:U001486
database_cross_reference: LCH_NW:sh85040344
database_cross_reference: LNC:LA17001-1
database_cross_reference: LNC:LA17611-7
database_cross_reference: LNC:LP115812-2
database_cross_reference: LNC:MTHU020850
database_cross_reference: LNC:MTHU038266
database_cross_reference: MDR:10006332
database_cross_reference: MDR:10006338
database_cross_reference: MDR:10006345
database_cross_reference: MDR:10012791
database_cross_reference: MDR:10013963
database_cross_reference: MDR:10013968
database_cross_reference: MDR:10013972
database_cross_reference: MDR:10013975
database_cross_reference: MDR:10040596
database_cross_reference: MDR:10040604
database_cross_reference: MDR:10041237
database_cross_reference: MDR:10041238
database_cross_reference: MEDCIN:115876
database_cross_reference: MEDCIN:353
database_cross_reference: MEDLINEPLUS:3077
database_cross_reference: MSH:D004417
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000486
database_cross_reference: NCI:C2998
database_cross_reference: NCI_CDISC:C2998
database_cross_reference: NCI_CTCAE:E13368
database_cross_reference: NCI_FDA:1816
database_cross_reference: NCI_NCI-GLOSS:CDR0000046183
database_cross_reference: NCI_NICHD:C2998
database_cross_reference: NDFRT:N0000001030
database_cross_reference: OMIM:MTHU037132
database_cross_reference: OMIM:MTHU037277
database_cross_reference: OMIM:MTHU038284

Obstructive lung disease
type: Class
subclass of: Functional respiratory abnormality
Definition: Obstruction of conducting airways of the lung.
MCID: MC00184247
PMOID: PMO:00011645
Subclass_of: Functional respiratory abnormality
Synonym: AIRWAY DISEASE OBSTRUCTIVE
Synonym: DISEASE OBSTRUCTIVE LUNG
Synonym: Disease obstructive lung
Synonym: LUNG DIS OBSTRUCTIVE
Synonym: LUNG DISEASE OBSTRUCTIVE
Synonym: Lung Disease, Obstructive
Synonym: Lung Diseases, Obstructive
Synonym: Lung Diseases, Obstructive [Disease/Finding]
Synonym: Lung disease obstructive
Synonym: Lungs--Diseases, Obstructive
Tree Number: T3.19.2.17
database_cross_reference: CCPSS:0045337
database_cross_reference: CCPSS:0046338
database_cross_reference: CHV:0000042221
database_cross_reference: CSP:2596-8463
database_cross_reference: CSP:4004-0004
database_cross_reference: CST:LUNG DIS
database_cross_reference: DO:DOID:2320
database_cross_reference: HPO:HP:0006536
database_cross_reference: LCH_NW:sh85078908
database_cross_reference: MDR:10013108
database_cross_reference: MDR:10025081
database_cross_reference: MDR:10029959
database_cross_reference: MDR:10029973
database_cross_reference: MDR:10061877
database_cross_reference: MSH:D008173
database_cross_reference: NDFRT:N0000001881
database_cross_reference: OMIM:MTHU042826

Recurrent singultus
type: Class
subclass of: Functional respiratory abnormality
Definition: A contraction of the diaphragm that repeats several times per minute. In humans, the abrupt rush of air into the lungs causes the epiglottis to close, creating a hic sound. Also known as synchronous diaphragmatic flutter (SDF), or singultus, from the Latin singult, the act of catching one's breath while sobbing. The hiccup is an involuntary action involving a reflex arc.
MCID: MC01400767
PMOID: PMO:00011648
Subclass_of: Functional respiratory abnormality
Synonym: Recurrent hiccough
Synonym: Recurrent hiccup
Synonym: Recurrent synchronous diaphragmatic flutter
Tree Number: T3.19.2.18
database_cross_reference: HPO:HP:0100247

Reduced vital capacity
type: Class
subclass of: Functional respiratory abnormality
Definition: An abnormal reduction on the vital capacity, which is defined as the total lung capacity (volume of air in the lungs at maximal inflation) less the residual volume (i.e., volume of air in the lungs following maximal exhalation) of the lung.
MCID: MC01400890
PMOID: PMO:00011649
Subclass_of: Functional respiratory abnormality
Synonym: Decreased vital capacity
Tree Number: T3.19.2.19
database_cross_reference: HPO:HP:0002792

Respiratory insufficiency
type: Class
subclass of: Functional respiratory abnormality
MCID: MC00010917
PMOID: PMO:00011650
Subclass_of: Functional respiratory abnormality
Synonym: INCOMPETENCE PULM VALVE
Synonym: INSUFFICIENCY PULM VALVE
Synonym: Incompetence, Pulmonary Valve
Synonym: Insufficiency, Pulmonary
Synonym: Insufficiency, Pulmonary Valve
Synonym: PR - Pulmonary regurgitation
Synonym: PULM REGURGITATION
Synonym: PULM VALVE INCOMPETENCE
Synonym: PULM VALVE INSUFFICIENCY
Synonym: PULM VALVE REGURGITATION
Tree Number: T3.19.2.20
database_cross_reference: BI:BI00107
database_cross_reference: CCPSS:0022933
database_cross_reference: CHV:0000010397
database_cross_reference: CSP:1393-3857
database_cross_reference: DO:DOID:14265
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001619
database_cross_reference: HPO:HP:0010444
database_cross_reference: ICD10:I37.1
database_cross_reference: ICD10AM:I37.1
database_cross_reference: MDR:10037408
database_cross_reference: MDR:10037448
database_cross_reference: MDR:10051697
database_cross_reference: MDR:10052842
database_cross_reference: MEDCIN:33375
database_cross_reference: MSH:D011665
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:424.3
database_cross_reference: NCI:C50848
database_cross_reference: NCI:C51447
database_cross_reference: NCI:C62436
database_cross_reference: NCI_FDA:2022
database_cross_reference: NCI_FDA:2023
database_cross_reference: NDFRT:N0000002547
database_cross_reference: OMIM:MTHU014357
database_cross_reference: OMIM:MTHU021746
database_cross_reference: RCD:X201L
database_cross_reference: SNM:F-70500
database_cross_reference: SNMI:D3-29052
database_cross_reference: SNOMEDCT_US:91434003

Restrictive ventilatory defect
type: Class
subclass of: Functional respiratory abnormality
Definition: A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus.
PMOID: PMO:00011664
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.21

Sneeze
type: Class
subclass of: Functional respiratory abnormality
Definition: A sudden violent, spasmodic, audible expiration of breath through the nose and mouth.
MCID: MC01401237
PMOID: PMO:00011665
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.22
database_cross_reference: HPO:HP:0025095

Tracheal tug on inspiration
type: Class
subclass of: Functional respiratory abnormality
Definition: Downward movement of the trachea during inspiration due to downward traction on the tracheobronchial tree.
MCID: MC01401531
PMOID: PMO:00011667
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.23
database_cross_reference: HPO:HP:0025008

Upper airway obstruction
type: Class
subclass of: Functional respiratory abnormality
Definition: Increased resistance to the passage of air in the upper airway.
MCID: MC00254156
PMOID: PMO:00011668
Subclass_of: Functional respiratory abnormality
Synonym: AIRWAY OBSTRUCTION UPPER
Synonym: airway obstruction upper
Synonym: airway obstructions upper
Synonym: upper airway obstruction
Tree Number: T3.19.2.24
database_cross_reference: CCPSS:0018730
database_cross_reference: CHV:0000047182
database_cross_reference: HPO:HP:0002781
database_cross_reference: MDR:10067775
database_cross_reference: OMIM:MTHU014450

Abnormality of the skeletal system
type: Class
subclass of: Phenotypic Abnormality
Definition: An abnormality of the skeletal system.
MCID: MC01000340
PMOID: PMO:00011670
Subclass_of: Phenotypic Abnormality
Synonym: Skeletal abnormalities
Synonym: Skeletal anomalies
Tree Number: T3.20
database_cross_reference: HPO:HP:0000924

Abnormality of skeletal morphology
type: Class
subclass of: Abnormality of the skeletal system
Definition: An abnormality of the form, structure, or size of the skeletal system.
MCID: MC01001241
PMOID: PMO:00011671
Subclass_of: Abnormality of the skeletal system
Synonym: Abnormally shaped skeletal
Tree Number: T3.20.1
database_cross_reference: HPO:HP:0011842

Abnormal appendicular skeleton morphology
type: Class
subclass of: Abnormality of skeletal morphology
Definition: An abnormality of the appendicular skeletal system, consisting of the of the limbs, shoulder and pelvic girdles.
MCID: MC01001239
PMOID: PMO:00011672
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.1
database_cross_reference: HPO:HP:0011844

Abnormal axial skeleton morphology
type: Class
subclass of: Abnormality of skeletal morphology
Definition: An abnormality of the axial skeleton, which comprises the skull, the vertebral column, the ribs and the sternum.
MCID: MC01002297
PMOID: PMO:00013265
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.2
database_cross_reference: HPO:HP:0009121

Abnormal bone structure
type: Class
subclass of: Abnormality of skeletal morphology
Definition: Any anomaly in the composite material or the layered arrangement of the bony skeleton.
MCID: MC01002947
PMOID: PMO:00013616
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.3
database_cross_reference: HPO:HP:0003330

Abnormal cartilage morphology
type: Class
subclass of: Abnormality of skeletal morphology
Definition: Any morphological abnormality of cartilage.
MCID: MC01002971
PMOID: PMO:00013808
Subclass_of: Abnormality of skeletal morphology
Synonym: Abnormal shape of cartilage
Tree Number: T3.20.1.4
database_cross_reference: HPO:HP:0002763

Abnormal joint morphology
type: Class
subclass of: Abnormality of skeletal morphology
Definition: An abnormal structure or form of the joints, i.e., one or more of the articulations where two bones join.
PMOID: PMO:00013815
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.5

Abnormal tendon morphology
type: Class
subclass of: Abnormality of skeletal morphology
Definition: An abnormality of the structure or form of the tendons, also often called sinews.
MCID: MC00999789
PMOID: PMO:00013934
Subclass_of: Abnormality of skeletal morphology
Synonym: Abnormal shape of tendon
Synonym: Abnormality of the sinew
Tree Number: T3.20.1.6
database_cross_reference: HPO:HP:0100261

Abnormality of cartilage morphology
type: Class
subclass of: Abnormality of skeletal morphology
Definition: Any abnormality of cartilage.
PMOID: PMO:00013944
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.7

Abnormality of growth plate morphology
type: Class
subclass of: Abnormality of skeletal morphology
Definition: A structural anomaly of the growth plates (epiphyseal plates), areas of cartilage located near the ends of long bones that are located between the metaphysis (widened part of the shaft of the bone) and the epiphysis (end of the bone) and in which growth occurs in the developing bone. After conclusion of bone growth, the growth plates ossify (harden into solid bone).
MCID: MC01396304
PMOID: PMO:00013948
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.8
database_cross_reference: HPO:HP:0025368

Abnormality of synovial bursa morphology
type: Class
subclass of: Abnormality of skeletal morphology
Definition: A structural anomaly of a synovial bursa.
MCID: MC01396369
PMOID: PMO:00013950
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.9
database_cross_reference: HPO:HP:0025231

Aplasia/hypoplasia involving the skeleton
type: Class
subclass of: Abnormality of skeletal morphology
Definition: Absence (due to failure to form) or underdevelopment of one or more components of the skeleton.
MCID: MC01396819
PMOID: PMO:00013952
Subclass_of: Abnormality of skeletal morphology
Synonym: Absent/small skeleton
Synonym: Absent/underdeveloped skeleton
Tree Number: T3.20.1.10
database_cross_reference: HPO:HP:0009115

Dysostosis multiplex
type: Class
subclass of: Abnormality of skeletal morphology
MCID: MC00043809
PMOID: PMO:00013953
Subclass_of: Abnormality of skeletal morphology
Synonym: Disease, Hurler's
Synonym: Disease;Hurlers
Synonym: Dysostosis multiplex (disorder)
Synonym: Dysostosis multiplex syndrome
Synonym: Ellis-Sheldon syndrome
Synonym: GARGOYLISM
Synonym: Gargoylism
Synonym: Gargoylism, Hurler Syndrome
Synonym: Gargoylisms
Synonym: HURLER
Tree Number: T3.20.1.11
database_cross_reference: CCPSS:0010694
database_cross_reference: CHV:0000016009
database_cross_reference: CHV:0000047707
database_cross_reference: CSP:1849-6334
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0000943
database_cross_reference: ICD10CM:E76.01
database_cross_reference: ICPC2P:T80001
database_cross_reference: JABL:463
database_cross_reference: MDR:10020470
database_cross_reference: MDR:10020471
database_cross_reference: MDR:10028048
database_cross_reference: MEDCIN:33580
database_cross_reference: MEDCIN:38229
database_cross_reference: MSH:D008059
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.5
database_cross_reference: NCI:C61261
database_cross_reference: OMIM:252800
database_cross_reference: OMIM:607014
database_cross_reference: OMIM:MTHU007185
database_cross_reference: RCD:X40Vy
database_cross_reference: RCD:X789y
database_cross_reference: SNM:D-3811
database_cross_reference: SNMI:D6-70110
database_cross_reference: SNMI:D6-70112
database_cross_reference: SNOMEDCT_US:190936000
database_cross_reference: SNOMEDCT_US:190938004
database_cross_reference: SNOMEDCT_US:254069004
database_cross_reference: SNOMEDCT_US:65327002
database_cross_reference: SNOMEDCT_US:75610003

Hyperostosis
type: Class
subclass of: Abnormality of skeletal morphology
Definition: Excessive growth or abnormal thickening of bone tissue.
MCID: MC00006553
PMOID: PMO:00013954
Subclass_of: Abnormality of skeletal morphology
Synonym: Bone Hypertrophies
Synonym: Bone Hypertrophy
Synonym: Bone hypertrophy
Synonym: Bone overgrowth
Synonym: Bony overgrowth
Synonym: HYPEROSTOSIS
Synonym: Hyperostoses
Synonym: Hyperostosis [Disease/Finding]
Synonym: Hyperostosis, NOS
Synonym: Hypertrophies, Bone
Tree Number: T3.20.1.12
database_cross_reference: CHV:0000006426
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:BONE DIS
database_cross_reference: DO:DOID:205
database_cross_reference: HPO:HP:0100774
database_cross_reference: ICD10:M89.3
database_cross_reference: ICD10AM:M89.3
database_cross_reference: ICD10AM:M89.39
database_cross_reference: ICD10CM:M89.3
database_cross_reference: ICD10CM:M89.30
database_cross_reference: MDR:10005973
database_cross_reference: MDR:10020698
database_cross_reference: MEDCIN:272981
database_cross_reference: MSH:D015576
database_cross_reference: MTHICD9:733.99
database_cross_reference: NCI:C34712
database_cross_reference: NDFRT:N0000003289
database_cross_reference: OMIM:MTHU036636
database_cross_reference: RCD:N33z4
database_cross_reference: SNM:M-71430
database_cross_reference: SNM:M-71450
database_cross_reference: SNMI:M-71430
database_cross_reference: SNOMEDCT_US:13814009
database_cross_reference: SNOMEDCT_US:203514008

Hyperplastic callus formation
type: Class
subclass of: Abnormality of skeletal morphology
Definition: Increased growth of callus, the bony and cartilaginous material that forms a connecting bridge across a bone fracture during fracture healing.
MCID: MC01000936
PMOID: PMO:00013955
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.13
database_cross_reference: HPO:HP:0030268

Skeletal dysplasia
type: Class
subclass of: Abnormality of skeletal morphology
Definition: A general term describing features characterized by abnormal development of bones and connective tissues.
MCID: MC00009283
PMOID: PMO:00013956
Subclass_of: Abnormality of skeletal morphology
Synonym: 4-00A OSTEOCHONDRODYSPLASIA SYNDROMES
Synonym: Congenital Skeletal Dysplasia
Synonym: OSTEOCHONDRODYSPLASIA SYNDROMES
Synonym: Osteochondrodysplasia
Synonym: Osteochondrodysplasia (disorder)
Synonym: Osteochondrodysplasia syndrome
Synonym: Osteochondrodysplasia syndrome (disorder)
Synonym: Osteochondrodysplasia, NOS
Synonym: Osteochondrodysplasia, unspecified
Synonym: Osteochondrodysplasias
Tree Number: T3.20.1.14
database_cross_reference: HPO:HP:0002652
database_cross_reference: ICD10:Q78.9
database_cross_reference: ICD10AM:Q78.9
database_cross_reference: ICD10CM:Q78.9
database_cross_reference: MEDCIN:330547
database_cross_reference: MSH:D010009
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84978
database_cross_reference: NCI_NICHD:C84978
database_cross_reference: NDFRT:N0000002249
database_cross_reference: OMIM:MTHU041797
database_cross_reference: RCD:X70Bq
database_cross_reference: SNM:M-74500
database_cross_reference: SNM:U000377
database_cross_reference: SNMI:D4-00A00
database_cross_reference: SNMI:D6-70240
database_cross_reference: SNOMEDCT_US:105985007
database_cross_reference: SNOMEDCT_US:205510001
database_cross_reference: SNOMEDCT_US:240190009
database_cross_reference: SNOMEDCT_US:378007

Abnormality of skeletal physiology
type: Class
subclass of: Abnormality of the skeletal system
Definition: An abnormality of the function of the skeletal system.
MCID: MC01001240
PMOID: PMO:00013965
Subclass_of: Abnormality of the skeletal system
Tree Number: T3.20.2
database_cross_reference: HPO:HP:0011843

Abnormality of skeletal maturation
type: Class
subclass of: Abnormality of skeletal physiology
Definition: The bones of the skeleton undergo a series of characteristic changes in size, shape, and calcification from fetal life until puberty. An abnormality of this process can include delayed or accelerated skeletal maturation, or deviation of some, but not all bones from the expected patterns of maturation.
MCID: MC01003081
PMOID: PMO:00013966
Subclass_of: Abnormality of skeletal physiology
Tree Number: T3.20.2.1
database_cross_reference: HPO:HP:0000927

Aseptic necrosis
type: Class
subclass of: Abnormality of skeletal physiology
Definition: A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply.
MCID: MC00001293
PMOID: PMO:00013974
Subclass_of: Abnormality of skeletal physiology
Synonym: Aseptic Necrosis of Head and Neck of Femur
Synonym: Aseptic necrosis femur
Synonym: Aseptic necrosis of head AND/OR neck of femur
Synonym: Aseptic necrosis of head AND/OR neck of femur (disorder)
Synonym: Aseptic necrosis of head and neck of femur
Synonym: Aseptic necrosis of head and/or neck of femur
Synonym: Avascular necrosis of bone
Synonym: aseptic necrosis
Synonym: bone necrosis
Synonym: osteonecrosis
Tree Number: T3.20.2.2
database_cross_reference: DO:DOID:10159
database_cross_reference: ICD9CM:733.42
database_cross_reference: MDR:10003463
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34404
database_cross_reference: SNMI:D1-61654
database_cross_reference: SNOMEDCT_US:29281007

Increased susceptibility to fractures
type: Class
subclass of: Abnormality of skeletal physiology
Definition: An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture.
MCID: MC01399225
PMOID: PMO:00013981
Subclass_of: Abnormality of skeletal physiology
Synonym: Abnormal susceptibility to fractures
Synonym: Bone fragility
Synonym: Frequent broken bones
Synonym: Increased bone fragility
Synonym: Increased tendency to fractures
Tree Number: T3.20.2.3
database_cross_reference: HPO:HP:0002659

Osteomyelitis
type: Class
subclass of: Abnormality of skeletal physiology
Definition: Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism.
MCID: MC00009297
PMOID: PMO:00013987
Subclass_of: Abnormality of skeletal physiology
Synonym: OM - Osteomyelitis
Synonym: OSTEOMYELITIS
Synonym: OSTM - Osteomyelitis
Synonym: Osteomyelitides
Synonym: Osteomyelitis (disorder)
Synonym: Osteomyelitis NOS
Synonym: Osteomyelitis NOS-unspec
Synonym: Osteomyelitis [Ambiguous]
Synonym: Osteomyelitis [Disease/Finding]
Synonym: Osteomyelitis, NOS
Tree Number: T3.20.2.4
database_cross_reference: AOD:0000005153
database_cross_reference: BI:BI00508
database_cross_reference: CCPSS:1018040
database_cross_reference: CHV:0000009088
database_cross_reference: COSTAR:539
database_cross_reference: CSP:2715-2811
database_cross_reference: CST:OSTEOMYELITIS
database_cross_reference: DXP:U002943
database_cross_reference: HPO:HP:0002754
database_cross_reference: ICD10:M86
database_cross_reference: ICD10:M86.9
database_cross_reference: ICD10AM:M86
database_cross_reference: ICD10AM:M86.9
database_cross_reference: ICD10AM:M86.99
database_cross_reference: ICD10CM:M86
database_cross_reference: ICD10CM:M86.9
database_cross_reference: ICD9CM:730.2
database_cross_reference: ICD9CM:730.20
database_cross_reference: ICPC2P:L70014
database_cross_reference: LCH:U003403
database_cross_reference: LCH_NW:sh85095971
database_cross_reference: LNC:LP128775-6
database_cross_reference: LNC:MTHU040697
database_cross_reference: MDR:10031252
database_cross_reference: MDR:10031259
database_cross_reference: MDR:10046076
database_cross_reference: MDR:10046086
database_cross_reference: MEDCIN:31232
database_cross_reference: MEDLINEPLUS:5739
database_cross_reference: MSH:D010019
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C27577
database_cross_reference: NCI_NCI-GLOSS:CDR0000471782
database_cross_reference: NCI_NICHD:C27577
database_cross_reference: NDFRT:N0000002256
database_cross_reference: OMIM:MTHU037798
database_cross_reference: RCD:N3020
database_cross_reference: RCD:N302z
database_cross_reference: RCD:X70AW
database_cross_reference: RCD:XE1Fz
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D1-60210
database_cross_reference: SNOMEDCT_US:156801003
database_cross_reference: SNOMEDCT_US:156810006
database_cross_reference: SNOMEDCT_US:203206001
database_cross_reference: SNOMEDCT_US:203207005
database_cross_reference: SNOMEDCT_US:203244005
database_cross_reference: SNOMEDCT_US:240141009
database_cross_reference: SNOMEDCT_US:268020008
database_cross_reference: SNOMEDCT_US:60168000

Abnormality of the periosteum
type: Class
subclass of: Abnormality of the skeletal system
MCID: MC01019111
PMOID: PMO:00013993
Subclass_of: Abnormality of the skeletal system
Tree Number: T3.20.3
database_cross_reference: HPO:HP:0040166

Abnormal periosteum morphology
type: Class
subclass of: Abnormality of the periosteum
Definition: An anomalous structure of the periosteum, i.e., of the membrane that covers the outer surface of bones.
MCID: MC01000915
PMOID: PMO:00013994
Subclass_of: Abnormality of the periosteum
Tree Number: T3.20.3.1
database_cross_reference: HPO:HP:0030313

Ectopic calcification
type: Class
subclass of: Abnormality of the skeletal system
Definition: Deposition of calcium salts in a tissue or location in which calcification does not normally occur.
MCID: MC01397949
PMOID: PMO:00013998
Subclass_of: Abnormality of the skeletal system
Tree Number: T3.20.4
database_cross_reference: HPO:HP:0010766

Calcific stippling
type: Class
subclass of: Ectopic calcification
Definition: An abnormal punctate (speckled, dot-like) pattern of calcifications in soft tissues within or surrounding bones (as observed on radiographs).
MCID: MC01397204
PMOID: PMO:00013999
Subclass_of: Ectopic calcification
Synonym: Discrete calcific stippling
Tree Number: T3.20.4.1
database_cross_reference: HPO:HP:0002832

Calcinosis cutis
type: Class
subclass of: Ectopic calcification
Definition: Deposition of calcium in the skin.
MCID: MC00002100
PMOID: PMO:00014001
Subclass_of: Ectopic calcification
Synonym: Calcinosis Cutis
Synonym: Calcinosis cutis (disorder)
Synonym: Cutaneous calcification
Synonym: Dystrophic calc of skin
Synonym: Dystrophic calcification of skin
Synonym: calcinosis cutis
Synonym: calcinosis cutis (diagnosis)
Tree Number: T3.20.4.2
database_cross_reference: CHV:0000002287
database_cross_reference: COSTAR:NOCODE
database_cross_reference: HPO:HP:0025520
database_cross_reference: ICD10:L94.2
database_cross_reference: ICD10AM:L94.2
database_cross_reference: ICD10CM:L94.2
database_cross_reference: MDR:10074496
database_cross_reference: MDR:10074505
database_cross_reference: MEDCIN:37183
database_cross_reference: MTHICD9:709.3
database_cross_reference: OMIM:MTHU039445
database_cross_reference: RCD:X40R7
database_cross_reference: SNM:M-55500
database_cross_reference: SNMI:D0-75610
database_cross_reference: SNOMEDCT_US:21323007

Chondrocalcinosis
type: Class
subclass of: Ectopic calcification
Definition: Radiographic evidence of articular calcification that represent calcium pyrophosphate depositions in soft tissue surrounding joints and at the insertions of tendons near joints (Entheses/Sharpey fibers) .
MCID: MC00173385
PMOID: PMO:00014002
Subclass_of: Ectopic calcification
Synonym: CHONDROCALCINOSIS
Synonym: CHONDROCALCINOSIS FAMILIARIS
Synonym: CHONDROCALCINOSIS, ARTICULAR
Synonym: CPDD
Synonym: CPDD - Calc pyroph deposit dis
Synonym: CPDD - Calcium pyrophosphate deposition disease
Synonym: CPPD - Calcium pyrophosphate deposition disease
Synonym: CPPD CRYSTAL DEPOSITION DISEASE
Synonym: CPPD-Calc pyroph depos disease
Synonym: Calc pyrophosph deposit dis
Tree Number: T3.20.4.3
database_cross_reference: AOD:0000005089
database_cross_reference: CCPSS:0032503
database_cross_reference: CHV:0000039124
database_cross_reference: COSTAR:U000134
database_cross_reference: CSP:1849-7902
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000744
database_cross_reference: HPO:HP:0000934
database_cross_reference: ICD10CM:M11.2
database_cross_reference: ICD9CM:712.2
database_cross_reference: ICD9CM:712.20
database_cross_reference: ICD9CM:712.3
database_cross_reference: ICPC2P:T99071
database_cross_reference: LCH:U000995
database_cross_reference: LCH_NW:sh85024677
database_cross_reference: MDR:10008688
database_cross_reference: MDR:10008689
database_cross_reference: MDR:10008690
database_cross_reference: MDR:10008691
database_cross_reference: MDR:10008720
database_cross_reference: MDR:10061761
database_cross_reference: MEDCIN:34403
database_cross_reference: MEDCIN:38257
database_cross_reference: MEDLINEPLUS:264
database_cross_reference: MSH:D002805
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:712.20
database_cross_reference: NDFRT:N0000000767
database_cross_reference: OMIM:MTHU005831
database_cross_reference: RCD:N021.
database_cross_reference: RCD:N021z
database_cross_reference: RCD:N022.
database_cross_reference: RCD:N0220
database_cross_reference: RCD:N022z
database_cross_reference: RCD:X702b
database_cross_reference: RCD:X702h
database_cross_reference: SNM:D-1183
database_cross_reference: SNMI:D6-34750
database_cross_reference: SNOMEDCT_US:156881000
database_cross_reference: SNOMEDCT_US:201624004
database_cross_reference: SNOMEDCT_US:201637001
database_cross_reference: SNOMEDCT_US:201648008
database_cross_reference: SNOMEDCT_US:201649000
database_cross_reference: SNOMEDCT_US:201650000
database_cross_reference: SNOMEDCT_US:201660009
database_cross_reference: SNOMEDCT_US:239832006
database_cross_reference: SNOMEDCT_US:239838005
database_cross_reference: SNOMEDCT_US:268142006
database_cross_reference: SNOMEDCT_US:60782007

Epiphyseal stippling
type: Class
subclass of: Ectopic calcification
Definition: The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses.
MCID: MC00002760
PMOID: PMO:00014004
Subclass_of: Ectopic calcification
Synonym: CHONDRODYSTROPHIA CALCIFICANS CONGEN
Synonym: Chondrdys punct stipl epiph gr
Synonym: Chondrodysplasia Punctata
Synonym: Chondrodysplasia Punctata (Stippled Epiphyses) Group
Synonym: Chondrodysplasia Punctata [Disease/Finding]
Synonym: Chondrodysplasia calcificans
Synonym: Chondrodysplasia calcificans congenita
Synonym: Chondrodysplasia punctata
Synonym: Chondrodysplasia punctata (disorder)
Synonym: Chondrodysplasia punctata (disorder) [Ambiguous]
Tree Number: T3.20.4.4
database_cross_reference: CHV:0000002898
database_cross_reference: DO:DOID:2581
database_cross_reference: HPO:HP:0010655
database_cross_reference: ICD10:Q77.3
database_cross_reference: ICD10AM:Q77.3
database_cross_reference: ICD10CM:Q77.3
database_cross_reference: MEDCIN:330544
database_cross_reference: MSH:D002806
database_cross_reference: MTH:U003262
database_cross_reference: NCI:C84632
database_cross_reference: NCI_NICHD:C84632
database_cross_reference: NDFRT:N0000000768
database_cross_reference: OMIM:MTHU050816
database_cross_reference: RCD:PG4C.
database_cross_reference: RCD:Xa0pI
database_cross_reference: SNM:M-22410
database_cross_reference: SNM:M-22750
database_cross_reference: SNMI:D4-00A60
database_cross_reference: SNOMEDCT_US:205486004
database_cross_reference: SNOMEDCT_US:22932004
database_cross_reference: SNOMEDCT_US:278715001
database_cross_reference: SNOMEDCT_US:360507004
database_cross_reference: SNOMEDCT_US:42778005

Gingival calcification
type: Class
subclass of: Ectopic calcification
Definition: Ectopic deposition of calcium salts found in the gingiva.
MCID: MC01398538
PMOID: PMO:00014009
Subclass_of: Ectopic calcification
Synonym: Gingival calcifications
Tree Number: T3.20.4.5
database_cross_reference: HPO:HP:0025141

Intervertebral disk calcification
type: Class
subclass of: Ectopic calcification
Definition: The presence of abnormal calcium deposition of the intervertebral disk.
MCID: MC00143888
PMOID: PMO:00014010
Subclass_of: Ectopic calcification
Synonym: Interverteb disk calcification
Synonym: Intervertebral disc calcification
Synonym: Intervertebral disk calcification (disorder)
Synonym: Intervertebral disk mineralized
Synonym: Multiple intervertebral disk calcifications
Tree Number: T3.20.4.6
database_cross_reference: HPO:HP:0005645
database_cross_reference: MDR:10055038
database_cross_reference: RCD:X70Ce
database_cross_reference: SNOMEDCT_US:240211000
database_cross_reference: SNOMEDCT_VET:240211000

Periarticular calcification
type: Class
subclass of: Ectopic calcification
Definition: Calcified deposits in soft tissue structures outside a joint.
MCID: MC00120509
PMOID: PMO:00014011
Subclass_of: Ectopic calcification
Synonym: Periarticular calcification (disorder)
Tree Number: T3.20.4.7
database_cross_reference: HPO:HP:0025477
database_cross_reference: RCD:X40R2
database_cross_reference: SNOMEDCT_US:237898004

Sternal punctate calcifications
type: Class
subclass of: Ectopic calcification
MCID: MC01401312
PMOID: PMO:00014012
Subclass_of: Ectopic calcification
Tree Number: T3.20.4.8
database_cross_reference: HPO:HP:0006637

Tarsal stippling
type: Class
subclass of: Ectopic calcification
Definition: The presence of abnormal punctate (speckled, dot-like) calcifications in one or more tarsal bones.
MCID: MC01401407
PMOID: PMO:00014013
Subclass_of: Ectopic calcification
Synonym: Punctate calcifications of tarsals
Synonym: Punctate tarsal calcification
Tree Number: T3.20.4.9
database_cross_reference: HPO:HP:0008131

Tracheal calcification
type: Class
subclass of: Ectopic calcification
Definition: Calcification (abnormal deposits of calcium) in the tracheal tissues.
MCID: MC00089338
PMOID: PMO:00014014
Subclass_of: Ectopic calcification
Synonym: Calcification of the trachea
Synonym: Calcification of trachea
Synonym: Calcification of trachea (disorder)
Synonym: Trachea calcifications
Synonym: Tracheal Calcification
Synonym: Tracheal calcifications
Synonym: Tracheal ectopic calcification
Synonym: tracheal calcification
Synonym: tracheal calcification (diagnosis)
Tree Number: T3.20.4.10
database_cross_reference: DO:DOID:14224
database_cross_reference: HPO:HP:0002787
database_cross_reference: MDR:10051880
database_cross_reference: MEDCIN:275993
database_cross_reference: NCI:C35314
database_cross_reference: OMIM:MTHU007984
database_cross_reference: OMIM:MTHU020582
database_cross_reference: RCD:H5y10
database_cross_reference: SNMI:D2-10310
database_cross_reference: SNOMEDCT_US:81089005

Abnormality of the thoracic cavity
type: Class
subclass of: Phenotypic Abnormality
MCID: MC01000849
PMOID: PMO:00014015
Subclass_of: Phenotypic Abnormality
Tree Number: T3.21
database_cross_reference: HPO:HP:0045027

Abnormality of the mediastinum
type: Class
subclass of: Abnormality of the thoracic cavity
MCID: MC01000850
PMOID: PMO:00014016
Subclass_of: Abnormality of the thoracic cavity
Tree Number: T3.21.1
database_cross_reference: HPO:HP:0045026

Mediastinal lymphadenopathy
type: Class
subclass of: Abnormality of the mediastinum
Definition: Swelling of lymph nodes within the mediastinum, the central compartment of the thoracic cavities that contains the heart and the great vessels, the esophagus, and trachea and other structures including lymph nodes.
MCID: MC00162986
PMOID: PMO:00014017
Subclass_of: Abnormality of the mediastinum
Synonym: Enlargement of mediastinal lymph node
Synonym: Lymphadenopathy mediastinal
Synonym: MEDIASTINAL LYMPH NODE ENLARGEMENT
Synonym: MEDIASTINAL LYMPHADENOPATHY
Synonym: Mediastinal lymphadenopathy (disorder)
Synonym: lymphadenopathy mediastinal
Synonym: mediastinal lymphadenopathy
Tree Number: T3.21.1.1
database_cross_reference: CCPSS:0025172
database_cross_reference: CHV:0000037782
database_cross_reference: DXP:U002532
database_cross_reference: HPO:HP:0100721
database_cross_reference: MDR:10025205
database_cross_reference: MDR:10027075
database_cross_reference: SNMI:DC-72330
database_cross_reference: SNOMEDCT_US:52324001
database_cross_reference: SNOMEDCT_VET:52324001

Pneumomediastinum
type: Class
subclass of: Abnormality of the mediastinum
Definition: The presence of free air in the mediastinum.
MCID: MC00007961
PMOID: PMO:00014018
Subclass_of: Abnormality of the mediastinum
Synonym: Emphysema, Mediastinal
Synonym: Emphysemas, Mediastinal
Synonym: MEDIASTINAL EMPHYSEMA
Synonym: Mediastinal Emphysema
Synonym: Mediastinal Emphysema [Disease/Finding]
Synonym: Mediastinal Emphysemas
Synonym: Mediastinal emphysema
Synonym: Mediastinal emphysema (disorder)
Synonym: Mediastinal emphysema [Ambiguous]
Synonym: PNEUMOMEDIASTINUM
Tree Number: T3.21.1.2
database_cross_reference: CCPSS:1010260
database_cross_reference: CHV:0000007837
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001524
database_cross_reference: DXP:U002531
database_cross_reference: HPO:HP:0025421
database_cross_reference: ICD10CM:J98.2
database_cross_reference: LCH:U006003
database_cross_reference: LCH_NW:sh85103623
database_cross_reference: MDR:10027073
database_cross_reference: MDR:10050184
database_cross_reference: MEDCIN:33000
database_cross_reference: MSH:D008478
database_cross_reference: MTHICD9:518.1
database_cross_reference: NCI:C98981
database_cross_reference: NCI_NICHD:C98981
database_cross_reference: NDFRT:N0000001961
database_cross_reference: RCD:H581.
database_cross_reference: SNM:M-36270
database_cross_reference: SNMI:D2-81180
database_cross_reference: SNOMEDCT_US:155627006
database_cross_reference: SNOMEDCT_US:16838000
database_cross_reference: SNOMEDCT_US:196144009
database_cross_reference: SNOMEDCT_US:266411000
database_cross_reference: SNOMEDCT_US:390899006

Abnormality of the voice
type: Class
subclass of: Phenotypic Abnormality
MCID: MC01000327
PMOID: PMO:00014019
Subclass_of: Phenotypic Abnormality
Synonym: Voice abnormality
Tree Number: T3.22
database_cross_reference: HPO:HP:0001608

Abnormal cry
type: Class
subclass of: Abnormality of the voice
Definition: Any anomaly of the vocalizing of an infant's crying, i.e.,the typically loud voice production that is accompanied by tears and agitation.
MCID: MC01395844
PMOID: PMO:00014020
Subclass_of: Abnormality of the voice
Tree Number: T3.22.1
database_cross_reference: HPO:HP:0025429

Cat cry
type: Class
subclass of: Abnormal cry
Definition: The presence of a characteristic high-pitched cry that sounds similar to the meowing of a kitten.
MCID: MC01397234
PMOID: PMO:00014021
Subclass_of: Abnormal cry
Synonym: cat-like cry
Tree Number: T3.22.1.1
database_cross_reference: HPO:HP:0200046

High-pitched cry
type: Class
subclass of: Abnormal cry
Definition: A type of crying in an abnormally high-pitched voice.
MCID: MC01398628
PMOID: PMO:00014022
Subclass_of: Abnormal cry
Tree Number: T3.22.1.2
database_cross_reference: HPO:HP:0025430

Staccato cry
type: Class
subclass of: Abnormal cry
Definition: A type of cry that is abnormal because it is consists of unusually shortened and detached vocalizations.
MCID: MC01401304
PMOID: PMO:00014023
Subclass_of: Abnormal cry
Tree Number: T3.22.1.3
database_cross_reference: HPO:HP:0025431

Weak cry
type: Class
subclass of: Abnormal cry
MCID: MC01401768
PMOID: PMO:00014024
Subclass_of: Abnormal cry
Tree Number: T3.22.1.4
database_cross_reference: HPO:HP:0001612

Abnormal speech prosody
type: Class
subclass of: Abnormality of the voice
Definition: An anomaly of the expressive patterns of speech that involve intonation, stress pattern, loudness variations, pausing, articulatory force, and rhythm.
MCID: MC01396144
PMOID: PMO:00014025
Subclass_of: Abnormality of the voice
Tree Number: T3.22.2
database_cross_reference: HPO:HP:0031434

Increased pitch variability of speech
type: Class
subclass of: Abnormal speech prosody
Definition: A speech pattern characterized by abnormally elevated variability of the pitch of the voice.
MCID: MC01399161
PMOID: PMO:00014026
Subclass_of: Abnormal speech prosody
Tree Number: T3.22.2.1
database_cross_reference: HPO:HP:0031436

Monotonic speech
type: Class
subclass of: Abnormal speech prosody
Definition: A speech pattern characterized by abnormally reduced or lacking variability of the pitch of the voice.
MCID: MC01399847
PMOID: PMO:00014027
Subclass_of: Abnormal speech prosody
Tree Number: T3.22.2.2
database_cross_reference: HPO:HP:0031435

Abnormally low-pitched voice
type: Class
subclass of: Abnormality of the voice
Definition: An abnormally low-pitched voice.
MCID: MC01001722
PMOID: PMO:00014028
Subclass_of: Abnormality of the voice
Tree Number: T3.22.3
database_cross_reference: HPO:HP:0010300

Dysphonia
type: Class
subclass of: Abnormality of the voice
Definition: An impairment in the ability to produce voice sounds.
MCID: MC00006367
PMOID: PMO:00014029
Subclass_of: Abnormality of the voice
Synonym: Croaky voice
Synonym: HOARSENESS
Synonym: Hoarse
Synonym: Hoarse (finding)
Synonym: Hoarse voice
Synonym: Hoarse voice quality
Synonym: Hoarseness
Synonym: Hoarseness - throat symptom
Synonym: Hoarseness [Disease/Finding]
Synonym: Hoarseness of Voice
Tree Number: T3.22.4
database_cross_reference: BI:BI00184
database_cross_reference: CCPSS:1017331
database_cross_reference: CHV:0000006207
database_cross_reference: COSTAR:375
database_cross_reference: CST:VOICE ALTERAT
database_cross_reference: DXP:U004420
database_cross_reference: HPO:HP:0001609
database_cross_reference: ICD10CM:R49.0
database_cross_reference: ICPC2P:R23004
database_cross_reference: LCH:U002207
database_cross_reference: LCH_NW:sh85061307
database_cross_reference: MDR:10020200
database_cross_reference: MDR:10020201
database_cross_reference: MDR:10020202
database_cross_reference: MEDCIN:217
database_cross_reference: MSH:D006685
database_cross_reference: MTH:U003301
database_cross_reference: MTHICD9:784.42
database_cross_reference: NCI:C47813
database_cross_reference: NCI_CTCAE:E13384
database_cross_reference: NCI_NICHD:C47813
database_cross_reference: NDFRT:N0000001549
database_cross_reference: OMIM:MTHU036364
database_cross_reference: OMIM:MTHU038765
database_cross_reference: RCD:1CA2.
database_cross_reference: RCD:1CAZ.
database_cross_reference: RCD:R0445
database_cross_reference: RCDSY:R0445
database_cross_reference: SNM:F-X6480
database_cross_reference: SNMI:F-F7260
database_cross_reference: SNOMEDCT_US:139661005
database_cross_reference: SNOMEDCT_US:139663008
database_cross_reference: SNOMEDCT_US:139664002
database_cross_reference: SNOMEDCT_US:158311009
database_cross_reference: SNOMEDCT_US:162391002
database_cross_reference: SNOMEDCT_US:162393004
database_cross_reference: SNOMEDCT_US:206974000
database_cross_reference: SNOMEDCT_US:50219008

Laryngeal dystonia
type: Class
subclass of: Dysphonia
Definition: A form of focal dystonia that affects the vocal cords, associated with involuntary contractions of the vocal cords causing interruptions of speech and affecting the voice quality and often leading to patterned, repeated breaks in speech.
MCID: MC00632977
PMOID: PMO:00014030
Subclass_of: Dysphonia
Synonym: Laryngeal dystonia (disorder)
Synonym: Spasmodic dysphonia
Tree Number: T3.22.4.1
database_cross_reference: HPO:HP:0012049
database_cross_reference: MDR:10067678
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU025383
database_cross_reference: SNOMEDCT_US:3331000119108

High pitched voice
type: Class
subclass of: Abnormality of the voice
Definition: An abnormal increase in the pitch (frequency) of the voice.
MCID: MC01398621
PMOID: PMO:00014031
Subclass_of: Abnormality of the voice
Synonym: High-pitched voice
Tree Number: T3.22.5
database_cross_reference: HPO:HP:0001620

Hoarse voice
type: Class
subclass of: Abnormality of the voice
Definition: Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.
MCID: MC00006367
PMOID: PMO:00014032
Subclass_of: Abnormality of the voice
Synonym: Croaky voice
Synonym: Dysphonia
Synonym: HOARSENESS
Synonym: Hoarse
Synonym: Hoarse (finding)
Synonym: Hoarse voice quality
Synonym: Hoarseness
Synonym: Hoarseness - throat symptom
Synonym: Hoarseness [Disease/Finding]
Synonym: Hoarseness of Voice
Tree Number: T3.22.6
database_cross_reference: BI:BI00184
database_cross_reference: CCPSS:1017331
database_cross_reference: CHV:0000006207
database_cross_reference: COSTAR:375
database_cross_reference: CST:VOICE ALTERAT
database_cross_reference: DXP:U004420
database_cross_reference: HPO:HP:0001609
database_cross_reference: ICD10CM:R49.0
database_cross_reference: ICPC2P:R23004
database_cross_reference: LCH:U002207
database_cross_reference: LCH_NW:sh85061307
database_cross_reference: MDR:10020200
database_cross_reference: MDR:10020201
database_cross_reference: MDR:10020202
database_cross_reference: MEDCIN:217
database_cross_reference: MSH:D006685
database_cross_reference: MTH:U003301
database_cross_reference: MTHICD9:784.42
database_cross_reference: NCI:C47813
database_cross_reference: NCI_CTCAE:E13384
database_cross_reference: NCI_NICHD:C47813
database_cross_reference: NDFRT:N0000001549
database_cross_reference: OMIM:MTHU036364
database_cross_reference: OMIM:MTHU038765
database_cross_reference: RCD:1CA2.
database_cross_reference: RCD:1CAZ.
database_cross_reference: RCD:R0445
database_cross_reference: RCDSY:R0445
database_cross_reference: SNM:F-X6480
database_cross_reference: SNMI:F-F7260
database_cross_reference: SNOMEDCT_US:139661005
database_cross_reference: SNOMEDCT_US:139663008
database_cross_reference: SNOMEDCT_US:139664002
database_cross_reference: SNOMEDCT_US:158311009
database_cross_reference: SNOMEDCT_US:162391002
database_cross_reference: SNOMEDCT_US:162393004
database_cross_reference: SNOMEDCT_US:206974000
database_cross_reference: SNOMEDCT_US:50219008

Hoarse cry
type: Class
subclass of: Hoarse voice
MCID: MC01398636
PMOID: PMO:00014033
Subclass_of: Hoarse voice
Tree Number: T3.22.6.1
database_cross_reference: HPO:HP:0001615

Hyponasal speech
type: Class
subclass of: Abnormality of the voice
Definition: Hyponasal speech is when there is an abnormally reduced nasal airflow during speech often in a setting of nasal obstruction or congestion.
MCID: MC01398769
PMOID: PMO:00014034
Subclass_of: Abnormality of the voice
Tree Number: T3.22.7
database_cross_reference: HPO:HP:0100271

Loss of voice
type: Class
subclass of: Abnormality of the voice
MCID: MC00001155
PMOID: PMO:00014035
Subclass_of: Abnormality of the voice
Synonym: APHONIA
Synonym: Absence of Voice
Synonym: Absence of voice
Synonym: Aphonia
Synonym: Aphonia (disorder)
Synonym: Aphonia [Disease/Finding]
Synonym: Does not phonate
Synonym: Does not produce voice
Synonym: Does not produce voice (finding)
Synonym: Does not vocalise
Tree Number: T3.22.8
database_cross_reference: CHV:0000001374
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:VOICE ALTERAT
database_cross_reference: DXP:U000219
database_cross_reference: HPO:HP:0001686
database_cross_reference: ICD10:R49.1
database_cross_reference: ICD10AM:R49.1
database_cross_reference: ICD10CM:R49.1
database_cross_reference: ICD9CM:784.41
database_cross_reference: ICPC2P:R23001
database_cross_reference: ICPC2P:R23005
database_cross_reference: MDR:10002953
database_cross_reference: MDR:10024882
database_cross_reference: MEDCIN:203706
database_cross_reference: MSH:D001044
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:784.41
database_cross_reference: NCI:C79539
database_cross_reference: NCI_CTCAE:E12589
database_cross_reference: NCI_NICHD:C79539
database_cross_reference: NDFRT:N0000000453
database_cross_reference: OMIM:MTHU037052
database_cross_reference: RCD:R0441
database_cross_reference: RCD:R0442
database_cross_reference: RCD:Ub1SK
database_cross_reference: RCD:Xa3RH
database_cross_reference: RCD:Xa7Hx
database_cross_reference: RCDSY:R0441
database_cross_reference: RCDSY:R0442
database_cross_reference: SNM:F-X6530
database_cross_reference: SNMI:F-F7005
database_cross_reference: SNOMEDCT_US:158307003
database_cross_reference: SNOMEDCT_US:158308008
database_cross_reference: SNOMEDCT_US:206970009
database_cross_reference: SNOMEDCT_US:206971008
database_cross_reference: SNOMEDCT_US:286329004
database_cross_reference: SNOMEDCT_US:286359009
database_cross_reference: SNOMEDCT_US:299702006
database_cross_reference: SNOMEDCT_US:441913003
database_cross_reference: SNOMEDCT_US:44564008

Nasal speech
type: Class
subclass of: Abnormality of the voice
Definition: A type of speech characterized by the presence of an abnormally increased nasal airflow during speech.
MCID: MC01399964
PMOID: PMO:00014036
Subclass_of: Abnormality of the voice
Synonym: Hypernasal speech
Synonym: Hypernasal voice
Synonym: Nasal voice
Tree Number: T3.22.9
database_cross_reference: HPO:HP:0001611

Speech articulation difficulties
type: Class
subclass of: Abnormality of the voice
Definition: Impairment in the physical production of speech sounds.
MCID: MC01401273
PMOID: PMO:00014037
Subclass_of: Abnormality of the voice
Tree Number: T3.22.10
database_cross_reference: HPO:HP:0009088

Vocal cord dysfunction
type: Class
subclass of: Abnormality of the voice
Definition: Any functional anomaly of the vocal cord.
MCID: MC01401763
PMOID: PMO:00014038
Subclass_of: Abnormality of the voice
Tree Number: T3.22.11
database_cross_reference: HPO:HP:0031801

Imperfect vocal cord adduction
type: Class
subclass of: Vocal cord dysfunction
MCID: MC01398975
PMOID: PMO:00014039
Subclass_of: Vocal cord dysfunction
Tree Number: T3.22.11.1
database_cross_reference: HPO:HP:0005934

Vocal cord paralysis
type: Class
subclass of: Vocal cord dysfunction
Definition: A loss of the ability to move the vocal folds.
MCID: MC00013655
PMOID: PMO:00014040
Subclass_of: Vocal cord dysfunction
Synonym: Inability to move vocal cords
Synonym: PARALYSIS VOCAL CORD
Synonym: Palsies, Vocal Cord
Synonym: Palsies, Vocal Fold
Synonym: Palsy, Vocal Cord
Synonym: Palsy, Vocal Fold
Synonym: Paralyses, Vocal Cord
Synonym: Paralysis of vocal cords
Synonym: Paralysis of vocal cords or larynx, unspecified
Synonym: Paralysis vocal cord
Tree Number: T3.22.11.2
database_cross_reference: CCPSS:0034969
database_cross_reference: CHV:0000013073
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:PARALYSIS VOCAL CORD
database_cross_reference: DXP:U004417
database_cross_reference: HPO:HP:0001605
database_cross_reference: ICD9CM:478.30
database_cross_reference: MDR:10033836
database_cross_reference: MDR:10046089
database_cross_reference: MDR:10047674
database_cross_reference: MEDCIN:30804
database_cross_reference: MSH:D014826
database_cross_reference: MTHICD9:478.30
database_cross_reference: NCI:C47814
database_cross_reference: NCI_NICHD:C47814
database_cross_reference: NDFRT:N0000003139
database_cross_reference: OMIM:MTHU014952
database_cross_reference: OMIM:MTHU025606
database_cross_reference: RCD:Xa9Bv
database_cross_reference: SNM:D-X761
database_cross_reference: SNMI:D2-04610
database_cross_reference: SNOMEDCT_US:155542001
database_cross_reference: SNOMEDCT_US:302912005
database_cross_reference: SNOMEDCT_US:87424003

Weak voice
type: Class
subclass of: Abnormality of the voice
Definition: Reduced intensity (volume) of speech.
MCID: MC00081356
PMOID: PMO:00014046
Subclass_of: Abnormality of the voice
Synonym: Decreased vocal loudness
Synonym: Fatigue, Voice
Synonym: Fatigues, Voice
Synonym: Soft voice
Synonym: VOICE FATIGUE
Synonym: Vocal fatigue
Synonym: Vocal fatigue (finding)
Synonym: Voice Fatigue
Synonym: Voice Fatigues
Synonym: Voice fatigue
Tree Number: T3.22.12
database_cross_reference: CHV:0000024646
database_cross_reference: DXP:U004419
database_cross_reference: HPO:HP:0001621
database_cross_reference: MEDCIN:281063
database_cross_reference: MSH:D014832
database_cross_reference: RCD:Ub1SY
database_cross_reference: SNMI:F-F7234
database_cross_reference: SNOMEDCT_US:8614008

Constitutional symptom
type: Class
subclass of: Phenotypic Abnormality
Definition: A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.
MCID: MC00003217
PMOID: PMO:00014047
Subclass_of: Phenotypic Abnormality
Synonym: CONSTITUTIONAL SYMPTOM
Synonym: CONSTITUTIONAL SYMPTOMS
Synonym: Constitutional Finding
Synonym: Constitutional Symptom
Synonym: Constitutional symptoms
Tree Number: T3.23
database_cross_reference: CCPSS:0032130
database_cross_reference: COSTAR:201
database_cross_reference: HPO:HP:0025142
database_cross_reference: LNC:LP96320-4
database_cross_reference: LNC:MTHU034799
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38469

Asthenia
type: Class
subclass of: Constitutional symptom
Definition: A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.
MCID: MC00001327
PMOID: PMO:00014048
Subclass_of: Constitutional symptom
Synonym: ASTHENIA
Synonym: Asthenia (finding)
Synonym: Asthenia NOS
Synonym: Asthenia [D]
Synonym: Asthenia [D] (finding)
Synonym: Asthenia [D] (situation)
Synonym: Asthenia [Disease/Finding]
Synonym: Asthenias
Synonym: Asthenic
Synonym: [D]Asthenia
Tree Number: T3.23.1
database_cross_reference: AOD:0000006718
database_cross_reference: BI:BI00549
database_cross_reference: CHV:0000001539
database_cross_reference: CST:ASTHENIA
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0025406
database_cross_reference: ICD10CM:R53.1
database_cross_reference: LCH:U000403
database_cross_reference: LCH_NW:sh85008856
database_cross_reference: MDR:10003549
database_cross_reference: MEDCIN:278510
database_cross_reference: MSH:D001247
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.79
database_cross_reference: NCI:C28132
database_cross_reference: NCI_NCI-GLOSS:CDR0000044787
database_cross_reference: NDFRT:N0000000496
database_cross_reference: PSY:04170
database_cross_reference: RCD:R0072
database_cross_reference: RCD:XM0yx
database_cross_reference: RCD:XM1AV
database_cross_reference: RCDSY:R0072
database_cross_reference: SNM:F-01620
database_cross_reference: SNMI:F-01380
database_cross_reference: SNOMEDCT_US:13791008
database_cross_reference: SNOMEDCT_US:158170006
database_cross_reference: SNOMEDCT_US:206768006
database_cross_reference: SNOMEDCT_US:274236006
database_cross_reference: SNOMEDCT_US:274638001

Body odor
type: Class
subclass of: Constitutional symptom
Definition: A perceived unpleasant smell given off by the body.
MCID: MC01397112
PMOID: PMO:00014049
Subclass_of: Constitutional symptom
Synonym: BO
Synonym: Body odour
Synonym: Bromhidrosis
Synonym: Bromidrosis
Synonym: Osmidrosis
Tree Number: T3.23.2
database_cross_reference: HPO:HP:0500001

Fish odor
type: Class
subclass of: Body odor
Definition: Body odor characterized by an offensive body odor and the smell of rotting fish due to the excessive excretion of trimethylaminuria (TMA) in the urine, sweat, and breath of affected individuals.
MCID: MC01398337
PMOID: PMO:00014050
Subclass_of: Body odor
Synonym: Fish odour
Synonym: Fishy body odor
Synonym: Fishy odor
Tree Number: T3.23.2.1
database_cross_reference: HPO:HP:0410020

Musty odor
type: Class
subclass of: Body odor
Definition: Pungent body odor.
MCID: MC01399916
PMOID: PMO:00014052
Subclass_of: Body odor
Synonym: Musty odour
Tree Number: T3.23.2.2
database_cross_reference: HPO:HP:0410021

Chest tightness
type: Class
subclass of: Constitutional symptom
Definition: An unpleasant sensation of tightness or pressure in the chest.
MCID: MC00078345
PMOID: PMO:00014053
Subclass_of: Constitutional symptom
Synonym: CHEST SYMPTOM TIGHTNESS
Synonym: CHEST TIGHTNESS OF
Synonym: CONSTRICTED CHEST
Synonym: CONSTRICTION CHEST
Synonym: Chest tightness of
Synonym: Constriction chest
Synonym: Feeling of chest tightness
Synonym: Feels Tightness in the Chest
Synonym: I feel tightness in my chest
Synonym: TIGHTNESS IN CHEST
Tree Number: T3.23.3
database_cross_reference: CCPSS:1017168
database_cross_reference: CHV:0000022913
database_cross_reference: CST:PAIN CHEST
database_cross_reference: DXP:U000846
database_cross_reference: HPO:HP:0031352
database_cross_reference: ICPC2P:A11004
database_cross_reference: MDR:10008492
database_cross_reference: MDR:10008493
database_cross_reference: MDR:10010780
database_cross_reference: MDR:10043854
database_cross_reference: MDR:10043858
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:786.59
database_cross_reference: NCI:C106402
database_cross_reference: NCI:FACT-L
database_cross_reference: RCD:R0658
database_cross_reference: RCD:XM08A
database_cross_reference: RCDSY:R0658
database_cross_reference: SNM:F-71560
database_cross_reference: SNMI:F-37160
database_cross_reference: SNOMEDCT_US:158401001
database_cross_reference: SNOMEDCT_US:207087000
database_cross_reference: SNOMEDCT_US:23924001

Chills
type: Class
subclass of: Constitutional symptom
Definition: A sudden sensation of feeling cold.
MCID: MC00043335
PMOID: PMO:00014054
Subclass_of: Constitutional symptom
Synonym: CHILL
Synonym: CHILLS
Synonym: Chill
Synonym: Chill (finding)
Synonym: Chill(s) NOS
Synonym: Chills NOS
Synonym: Chills [Disease/Finding]
Synonym: [D]Chill(s) NOS
Synonym: [D]Chill(s) NOS (context-dependent category)
Synonym: [D]Chill(s) NOS (situation)
Tree Number: T3.23.4
database_cross_reference: AOD:0000004397
database_cross_reference: CCPSS:1000736
database_cross_reference: CHV:0000015674
database_cross_reference: COSTAR:U000129
database_cross_reference: CST:CHILLS
database_cross_reference: DXP:U000732
database_cross_reference: HPO:HP:0025143
database_cross_reference: ICD10CM:R68.83
database_cross_reference: ICPC2EENG:A02
database_cross_reference: ICPC2P:A02001
database_cross_reference: LNC:MTHU013512
database_cross_reference: MDR:10008531
database_cross_reference: MEDCIN:7
database_cross_reference: MSH:D023341
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.64
database_cross_reference: NCI:C35143
database_cross_reference: NCI_CTCAE:E11074
database_cross_reference: NCI_FDA:2191
database_cross_reference: NCI_NICHD:C35143
database_cross_reference: NDFRT:N0000004252
database_cross_reference: RCD:R00z1
database_cross_reference: RCD:X76Dn
database_cross_reference: RCDSY:R00z1
database_cross_reference: SNM:F-03260
database_cross_reference: SNMI:F-03260
database_cross_reference: SNOMEDCT_US:158179007
database_cross_reference: SNOMEDCT_US:206785008
database_cross_reference: SNOMEDCT_US:43724002

Rigors
type: Class
subclass of: Chills
Definition: Severe chills with violent shivering. A rigor is an episode of shaking or exaggerated shivering which can occur with a high fever.
MCID: MC00145153
PMOID: PMO:00014055
Subclass_of: Chills
Synonym: AGUE
Synonym: CHILL SHAKING
Synonym: Having rigors
Synonym: Having rigors (finding)
Synonym: RIGOR
Synonym: RIGORS
Synonym: Rigor
Synonym: Rigor (finding)
Synonym: Rigor - Temperature-associated observation
Synonym: Rigor - symptom
Tree Number: T3.23.4.1
database_cross_reference: CCPSS:0013247
database_cross_reference: CCPSS:1014687
database_cross_reference: CHV:0000033399
database_cross_reference: CST:CHILLS
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U003390
database_cross_reference: HPO:HP:0025145
database_cross_reference: ICPC2P:A02004
database_cross_reference: MDR:10039175
database_cross_reference: MDR:10039176
database_cross_reference: MDR:10039177
database_cross_reference: MDR:10076336
database_cross_reference: MDR:10076459
database_cross_reference: MEDCIN:6020
database_cross_reference: MEDCIN:8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C111658
database_cross_reference: NCI_NICHD:C111658
database_cross_reference: RCD:X76EQ
database_cross_reference: RCD:XE0qf
database_cross_reference: RCD:Xa96g
database_cross_reference: SNMI:F-03266
database_cross_reference: SNOMEDCT_US:139110001
database_cross_reference: SNOMEDCT_US:161854004
database_cross_reference: SNOMEDCT_US:248457000
database_cross_reference: SNOMEDCT_US:267027008
database_cross_reference: SNOMEDCT_US:38880002

Fatigue
type: Class
subclass of: Constitutional symptom
Definition: A subjective feeling of tiredness characterized by a lack of energy and motivation.
MCID: MC00004974
PMOID: PMO:00014056
Subclass_of: Constitutional symptom
Synonym: Energy decreased
Synonym: FATIGUE
Synonym: Fatigue (finding)
Synonym: Fatigue NOS
Synonym: Fatigue [Disease/Finding]
Synonym: Fatigue extreme
Synonym: Fatigued
Synonym: Feeling of total lack of energy
Synonym: Lack (of);energy
Synonym: Lack of Energy
Tree Number: T3.23.5
database_cross_reference: AOD:0000001768
database_cross_reference: AOD:0000021618
database_cross_reference: AOD:0000021621
database_cross_reference: BI:BI00028
database_cross_reference: CCPSS:1014729
database_cross_reference: CHV:0000004914
database_cross_reference: COSTAR:298
database_cross_reference: CSP:1385-2059
database_cross_reference: CST:ASTHENIA
database_cross_reference: DXP:U001451
database_cross_reference: HPO:HP:0012378
database_cross_reference: ICD10CM:R53.83
database_cross_reference: ICPC2P:A04001
database_cross_reference: ICPC2P:A04004
database_cross_reference: LCH:U001739
database_cross_reference: LCH_NW:sh85047465
database_cross_reference: LNC:LA7542-9
database_cross_reference: LNC:MTHU013358
database_cross_reference: MDR:10016256
database_cross_reference: MDR:10016257
database_cross_reference: MDR:10016356
database_cross_reference: MDR:10024862
database_cross_reference: MDR:10043889
database_cross_reference: MDR:10043890
database_cross_reference: MDR:10047871
database_cross_reference: MDR:10057841
database_cross_reference: MEDCIN:273174
database_cross_reference: MEDCIN:314400
database_cross_reference: MEDLINEPLUS:5324
database_cross_reference: MSH:D005221
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.79
database_cross_reference: NCI:C3036
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CDISC:C3036
database_cross_reference: NCI_CTCAE:E11098
database_cross_reference: NCI_FDA:1849
database_cross_reference: NCI_NCI-GLOSS:CDR0000321374
database_cross_reference: NCI_NICHD:C3036
database_cross_reference: NDFRT:N0000001216
database_cross_reference: OMIM:MTHU010062
database_cross_reference: PDQ:CDR0000041390
database_cross_reference: PSY:19400
database_cross_reference: PSY:53290
database_cross_reference: RCD:1682.
database_cross_reference: RCD:R0071
database_cross_reference: RCD:R0075
database_cross_reference: RCD:X76Ai
database_cross_reference: RCD:XM06o
database_cross_reference: RCD:Xa96S
database_cross_reference: RCDSY:R0071
database_cross_reference: RCDSY:R0075
database_cross_reference: SNM:F-01610
database_cross_reference: SNMI:F-01360
database_cross_reference: SNOMEDCT_US:139126000
database_cross_reference: SNOMEDCT_US:158169005
database_cross_reference: SNOMEDCT_US:206767001
database_cross_reference: SNOMEDCT_US:206771003
database_cross_reference: SNOMEDCT_US:248274002
database_cross_reference: SNOMEDCT_US:302758002
database_cross_reference: SNOMEDCT_US:367392001
database_cross_reference: SNOMEDCT_US:84229001

Chronic fatigue
type: Class
subclass of: Fatigue
Definition: Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer.
MCID: MC01397302
PMOID: PMO:00014057
Subclass_of: Fatigue
Synonym: Chronic extreme exhaustion
Tree Number: T3.23.5.1
database_cross_reference: HPO:HP:0012432

Episodic fatigue
type: Class
subclass of: Fatigue
Definition: Intermittent and recurrent bouts of a subjective feeling of tiredness characterized by a lack of energy and motivation.
MCID: MC01001113
PMOID: PMO:00014058
Subclass_of: Fatigue
Tree Number: T3.23.5.2
database_cross_reference: HPO:HP:0012431

Postexertional malaise
type: Class
subclass of: Fatigue
Definition: A subjective feeling of tiredness characterized by a lack of energy and motivation and that is induced by exertion or exercise.
MCID: MC01400504
PMOID: PMO:00014059
Subclass_of: Fatigue
Synonym: Exercise-induced fatigue
Synonym: Exercise-induced malaise
Synonym: Postexertional fatigue
Tree Number: T3.23.5.3
database_cross_reference: HPO:HP:0030973

Gangrene
type: Class
subclass of: Constitutional symptom
Definition: A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).
MCID: MC00005439
PMOID: PMO:00014060
Subclass_of: Constitutional symptom
Synonym: 546 GANGRENES
Synonym: GANGRENE
Synonym: GANGRENES
Synonym: Gangrene (disorder)
Synonym: Gangrene (morphologic abnormality)
Synonym: Gangrene NOS
Synonym: Gangrene [Disease/Finding]
Synonym: Gangrene, NOS
Synonym: Gangrenes
Synonym: Gangrenous
Tree Number: T3.23.6
database_cross_reference: AOD:0000004489
database_cross_reference: CCPSS:1017512
database_cross_reference: CHV:0000005347
database_cross_reference: COSTAR:U000312
database_cross_reference: CSP:0944-7081
database_cross_reference: CST:GANGRENE
database_cross_reference: DXP:U001639
database_cross_reference: HPO:HP:0100758
database_cross_reference: ICD9CM:785.4
database_cross_reference: ICPC2P:K92004
database_cross_reference: LCH:U001915
database_cross_reference: LCH_NW:sh85053025
database_cross_reference: MDR:10017711
database_cross_reference: MDR:10017718
database_cross_reference: MEDCIN:30967
database_cross_reference: MEDCIN:6245
database_cross_reference: MEDLINEPLUS:5580
database_cross_reference: MSH:D005734
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:785.4
database_cross_reference: NCI:C50573
database_cross_reference: NCI_FDA:1873
database_cross_reference: NDFRT:N0000001309
database_cross_reference: OMIM:MTHU037861
database_cross_reference: RCD:R054.
database_cross_reference: RCD:R054z
database_cross_reference: RCD:XM07q
database_cross_reference: RCDSY:R054.
database_cross_reference: RCDSY:R054z
database_cross_reference: SNM:M-54600
database_cross_reference: SNM:U000349
database_cross_reference: SNMI:M-54600
database_cross_reference: SNOMEDCT_US:158349008
database_cross_reference: SNOMEDCT_US:158352000
database_cross_reference: SNOMEDCT_US:207019006
database_cross_reference: SNOMEDCT_US:207024009
database_cross_reference: SNOMEDCT_US:263765007
database_cross_reference: SNOMEDCT_US:36024000
database_cross_reference: SNOMEDCT_US:372070002

Hot flashes
type: Class
subclass of: Constitutional symptom
Definition: Sudden feelings of warmth that are generally most pronounced over the face, neck and chest.
MCID: MC00184212
PMOID: PMO:00014061
Subclass_of: Constitutional symptom
Synonym: Climacteric flushing
Synonym: Climacteric flushing (disorder)
Synonym: FLASH HOT
Synonym: FLUSH HOT
Synonym: Feeling of hot flushes
Synonym: Flash hot
Synonym: Flashes, Hot
Synonym: Flush hot
Synonym: HOT FLASH
Synonym: HOT FLASHES
Tree Number: T3.23.7
database_cross_reference: BI:BI00388
database_cross_reference: CCPSS:1006550
database_cross_reference: CHV:0000006287
database_cross_reference: CHV:0000042193
database_cross_reference: COSTAR:391
database_cross_reference: COSTAR:U000406
database_cross_reference: CSP:5004-0040
database_cross_reference: CST:VASODILAT
database_cross_reference: HPO:HP:0031217
database_cross_reference: ICPC2P:K29021
database_cross_reference: ICPC2P:X11021
database_cross_reference: MDR:10016350
database_cross_reference: MDR:10016752
database_cross_reference: MDR:10016820
database_cross_reference: MDR:10020407
database_cross_reference: MDR:10020408
database_cross_reference: MDR:10020411
database_cross_reference: MDR:10020413
database_cross_reference: MDR:10020417
database_cross_reference: MDR:10027301
database_cross_reference: MDR:10027311
database_cross_reference: MDR:10060800
database_cross_reference: MEDCIN:1064
database_cross_reference: MEDLINEPLUS:62
database_cross_reference: MSH:D019584
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3109
database_cross_reference: NCI_CTCAE:E13781
database_cross_reference: NCI_FDA:2153
database_cross_reference: NCI_NCI-GLOSS:CDR0000256567
database_cross_reference: NDFRT:N0000003943
database_cross_reference: PDQ:CDR0000042906
database_cross_reference: RCD:K5A20
database_cross_reference: RCD:XaBYP
database_cross_reference: SNM:F-30490
database_cross_reference: SNMI:F-81870
database_cross_reference: SNOMEDCT_US:198436008
database_cross_reference: SNOMEDCT_US:389318003
database_cross_reference: SNOMEDCT_US:390053008
database_cross_reference: SNOMEDCT_US:427368007
database_cross_reference: SNOMEDCT_US:67443009

Impairment of activities of daily living
type: Class
subclass of: Constitutional symptom
Definition: Difficulty in performing one or more activities normally performed every day, such as eating, bathing, dressing, grooming, work, homemaking, and leisure.
MCID: MC01398970
PMOID: PMO:00014062
Subclass_of: Constitutional symptom
Tree Number: T3.23.8
database_cross_reference: HPO:HP:0031058

Impaired ability to bathe oneself
type: Class
subclass of: Impairment of activities of daily living
Definition: This term applies to an individual who requires help to bathe more than one part of the body, get in or out of the tub or shower, or who requires total bathing.
MCID: MC01398903
PMOID: PMO:00014063
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.1
database_cross_reference: HPO:HP:0031059

Impaired ability to dress oneself
type: Class
subclass of: Impairment of activities of daily living
Definition: This applies to an individual who needs help with dressing or needs to be completely dressed.
MCID: MC01398904
PMOID: PMO:00014064
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.2
database_cross_reference: HPO:HP:0031060

Impaired continence
type: Class
subclass of: Impairment of activities of daily living
Definition: Partial or total incontinence of bowel or bladder.
MCID: MC01398913
PMOID: PMO:00014065
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.3
database_cross_reference: HPO:HP:0031064

Impaired feeding ability
type: Class
subclass of: Impairment of activities of daily living
Definition: Applies to an individual who needs partial or total help with feeding or requires parenteral feeding.
MCID: MC01398923
PMOID: PMO:00014070
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.4
database_cross_reference: HPO:HP:0031063

Impaired toileting ability
type: Class
subclass of: Impairment of activities of daily living
Definition: This term applies to an individual who requires help transferring to the toilet, cleaning self or who uses bedpan or commode.
MCID: MC01398958
PMOID: PMO:00014071
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.5
database_cross_reference: HPO:HP:0031061

Impaired transferring ability
type: Class
subclass of: Impairment of activities of daily living
Definition: Applies to an individual who needs help in moving from bed to chair or requires a complete transfer.
MCID: MC01398960
PMOID: PMO:00014072
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.6
database_cross_reference: HPO:HP:0031062

Night sweats
type: Class
subclass of: Constitutional symptom
Definition: Occurence of excessive sweating during sleep.
MCID: MC00008901
PMOID: PMO:00014073
Subclass_of: Constitutional symptom
Synonym: NIGHT SWEAT
Synonym: NIGHT SWEATS
Synonym: Night Sweating
Synonym: Night Sweats
Synonym: Night sweat
Synonym: Night sweats (finding)
Synonym: Nocturnal hyperhidrosis
Synonym: Nocturnal perspiration
Synonym: Problem;sweating;night
Synonym: night sweat
Tree Number: T3.23.9
database_cross_reference: BI:BI00355
database_cross_reference: CCPSS:1014502
database_cross_reference: CHV:0000008720
database_cross_reference: COSTAR:518
database_cross_reference: CST:SWEAT
database_cross_reference: DXP:U002804
database_cross_reference: HPO:HP:0030166
database_cross_reference: ICD10CM:R61
database_cross_reference: ICPC2P:A09002
database_cross_reference: ICPC2P:A09005
database_cross_reference: LNC:LP75171-6
database_cross_reference: LNC:MTHU013525
database_cross_reference: MDR:10029409
database_cross_reference: MDR:10029410
database_cross_reference: MDR:10052427
database_cross_reference: MEDCIN:272
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3279
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_NICHD:C3279
database_cross_reference: RCD:X76A5
database_cross_reference: SNM:F-03310
database_cross_reference: SNMI:F-42210
database_cross_reference: SNOMEDCT_US:139115006
database_cross_reference: SNOMEDCT_US:161859009
database_cross_reference: SNOMEDCT_US:42984000

Pain
type: Class
subclass of: Constitutional symptom
Definition: An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
MCID: MC00009627
PMOID: PMO:00014074
Subclass_of: Constitutional symptom
Synonym: A26-A29 TYPES OF PAIN
Synonym: Dolor
Synonym: PAIN
Synonym: Pain (finding)
Synonym: Pain NOS
Synonym: Pain [Disease/Finding]
Synonym: Pain finding
Synonym: Pain finding (finding)
Synonym: Pain observations
Synonym: Pain symptoms
Tree Number: T3.23.10
database_cross_reference: AOD:0000002779
database_cross_reference: AOD:0000002780
database_cross_reference: BI:BI00754
database_cross_reference: CCPSS:0035760
database_cross_reference: CHV:0000009185
database_cross_reference: COSTAR:548
database_cross_reference: CSP:2683-4824
database_cross_reference: CST:PAIN
database_cross_reference: HPO:HP:0012531
database_cross_reference: ICD10:R52.9
database_cross_reference: ICD10AM:R52.9
database_cross_reference: ICD10CM:R52
database_cross_reference: ICD9CM:338-338.99
database_cross_reference: ICPC2P:A01002
database_cross_reference: ICPC2P:A29020
database_cross_reference: LCH:U003436
database_cross_reference: LCH_NW:sh85096617
database_cross_reference: LNC:LA17107-6
database_cross_reference: LNC:LA7460-4
database_cross_reference: LNC:MTHU021175
database_cross_reference: LNC:MTHU029813
database_cross_reference: MDR:10033371
database_cross_reference: MDR:10033470
database_cross_reference: MEDCIN:283263
database_cross_reference: MEDCIN:314434
database_cross_reference: MEDLINEPLUS:351
database_cross_reference: MSH:D010146
database_cross_reference: MTH:306
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.96
database_cross_reference: NCI:C25271
database_cross_reference: NCI:C3303
database_cross_reference: NCI:ESAS
database_cross_reference: NCI:LASA
database_cross_reference: NCI_CTCAE:E11167
database_cross_reference: NCI_FDA:1994
database_cross_reference: NCI_NICHD:C3303
database_cross_reference: NDFRT:N0000002278
database_cross_reference: OMIM:MTHU033713
database_cross_reference: PDQ:CDR0000041399
database_cross_reference: PSY:36150
database_cross_reference: RCD:Xa07F
database_cross_reference: RCD:Xa0yP
database_cross_reference: SNM:F-82600
database_cross_reference: SNMI:F-A2600
database_cross_reference: SNOMEDCT_US:162412006
database_cross_reference: SNOMEDCT_US:22253000
database_cross_reference: SNOMEDCT_US:279075009
database_cross_reference: SNOMEDCT_US:366981002
database_cross_reference: SNOMEDCT_US:367206007

Abdominal pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
MCID: MC00000120
PMOID: PMO:00014075
Subclass_of: Pain
Synonym: ABDOMEN PAIN
Synonym: ABDOMINAL PAIN
Synonym: ABDOMINAL PAIN NOS
Synonym: AP - Abdominal pain
Synonym: Abd. pain
Synonym: Abdmnal pain unspcf site
Synonym: Abdo pain
Synonym: Abdominal Pain
Synonym: Abdominal Pain [Disease/Finding]
Synonym: Abdominal Pains
Tree Number: T3.23.10.1
database_cross_reference: AOD:0000005516
database_cross_reference: BI:BI00206
database_cross_reference: CCPSS:1017336
database_cross_reference: CHV:0000000535
database_cross_reference: COSTAR:004
database_cross_reference: COSTAR:U000001
database_cross_reference: CST:PAIN ABDO
database_cross_reference: DXP:U000023
database_cross_reference: HPO:HP:0002027
database_cross_reference: ICD10CM:R10.9
database_cross_reference: ICD9CM:789.0
database_cross_reference: ICD9CM:789.00
database_cross_reference: ICPC2P:D01006
database_cross_reference: LCH_NW:sh85000111
database_cross_reference: LNC:LA15468-4
database_cross_reference: LNC:MTHU013636
database_cross_reference: MDR:10000039
database_cross_reference: MDR:10000040
database_cross_reference: MDR:10000081
database_cross_reference: MDR:10000085
database_cross_reference: MDR:10018796
database_cross_reference: MDR:10033373
database_cross_reference: MDR:10033374
database_cross_reference: MEDCIN:475
database_cross_reference: MEDLINEPLUS:3061
database_cross_reference: MSH:D015746
database_cross_reference: MTH:306
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26682
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CTCAE:E10460
database_cross_reference: NCI_FDA:1685
database_cross_reference: NCI_NICHD:C26682
database_cross_reference: NDFRT:N0000003309
database_cross_reference: OMIM:MTHU036407
database_cross_reference: RCD:1969.
database_cross_reference: RCD:R090.
database_cross_reference: RCD:R090z
database_cross_reference: RCDSY:R090.
database_cross_reference: RCDSY:R090z
database_cross_reference: SNMI:F-50860
database_cross_reference: SNOMEDCT_US:139313005
database_cross_reference: SNOMEDCT_US:158498003
database_cross_reference: SNOMEDCT_US:158512003
database_cross_reference: SNOMEDCT_US:207205003
database_cross_reference: SNOMEDCT_US:207230000
database_cross_reference: SNOMEDCT_US:21522001

Allodynia
type: Class
subclass of: Pain
Definition: Pain due to a stimulus that does not normally provoke pain.
MCID: MC00006526
PMOID: PMO:00014078
Subclass_of: Pain
Synonym: HYPERALGESIA
Synonym: HYPERALGIA
Synonym: Hyperalgesia
Synonym: Hyperalgesia (finding)
Synonym: Hyperalgesia [Disease/Finding]
Synonym: Hyperalgesias
Synonym: Hyperalgesic Sensations
Synonym: Hyperalgia
Synonym: Hyperpathia
Synonym: Hyperpathia (finding)
Tree Number: T3.23.10.2
database_cross_reference: CCPSS:0048940
database_cross_reference: CHV:0000006400
database_cross_reference: CSP:4003-0026
database_cross_reference: CST:HYPERALGESIA
database_cross_reference: HPO:HP:0012533
database_cross_reference: HPO:HP:0031005
database_cross_reference: LCH_NW:sh92000586
database_cross_reference: MDR:10020573
database_cross_reference: MDR:10065952
database_cross_reference: MSH:D006930
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34703
database_cross_reference: NCI_NICHD:C34703
database_cross_reference: NDFRT:N0000001574
database_cross_reference: OMIM:MTHU044601
database_cross_reference: PSY:23741
database_cross_reference: RCD:X75t9
database_cross_reference: RCD:Xa0yS
database_cross_reference: SNM:F-82630
database_cross_reference: SNMI:F-A2630
database_cross_reference: SNOMEDCT_US:140908006
database_cross_reference: SNOMEDCT_US:163706006
database_cross_reference: SNOMEDCT_US:279078006
database_cross_reference: SNOMEDCT_US:55406008

Anal pain
type: Class
subclass of: Pain
Definition: Pain in and around the anus or rectum (perianal region).
MCID: MC00081003
PMOID: PMO:00014079
Subclass_of: Pain
Synonym: ANAL PAIN
Synonym: Anal Pain
Synonym: Anal pain (disorder)
Synonym: Anal pain (finding)
Synonym: Anus pain
Synonym: Pain anal
Synonym: Pain;anal
Synonym: Rectal pain
Synonym: anal pain
Synonym: anal pain (symptom)
Tree Number: T3.23.10.3
database_cross_reference: CHV:0000024076
database_cross_reference: DXP:U000165
database_cross_reference: HPO:HP:0500005
database_cross_reference: ICPC2P:D04001
database_cross_reference: MDR:10002167
database_cross_reference: MDR:10002854
database_cross_reference: MDR:10033377
database_cross_reference: MEDCIN:110377
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78172
database_cross_reference: NCI_CTCAE:E10486
database_cross_reference: RCD:J5747
database_cross_reference: SNMI:D5-44070
database_cross_reference: SNOMEDCT_US:68653001

Ankle pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the ankle.
MCID: MC00081006
PMOID: PMO:00014080
Subclass_of: Pain
Synonym: ANKLE PAIN
Synonym: Ankle arthralgia
Synonym: Ankle joint pain
Synonym: Ankle joint pain (finding)
Synonym: Ankle pain (finding)
Synonym: Arthralgia of ankle
Synonym: PAIN ANKLE
Synonym: Pain ankle
Synonym: Pain in ankle
Synonym: Pain;ankle
Tree Number: T3.23.10.4
database_cross_reference: CCPSS:1017361
database_cross_reference: CHV:0000024081
database_cross_reference: CST:PAIN
database_cross_reference: DXP:U000193
database_cross_reference: HPO:HP:0030840
database_cross_reference: ICPC2P:L16001
database_cross_reference: ICPC2P:L16002
database_cross_reference: MDR:10033379
database_cross_reference: MDR:10033420
database_cross_reference: MDR:10033501
database_cross_reference: MEDCIN:337339
database_cross_reference: MEDCIN:945
database_cross_reference: OMIM:MTHU016464
database_cross_reference: RCD:N094P
database_cross_reference: RCD:X75sF
database_cross_reference: SNOMEDCT_US:202475005
database_cross_reference: SNOMEDCT_US:202490009
database_cross_reference: SNOMEDCT_US:203124006
database_cross_reference: SNOMEDCT_US:247373008

Arthralgia
type: Class
subclass of: Pain
Definition: Joint pain.
MCID: MC00001261
PMOID: PMO:00014081
Subclass_of: Pain
Synonym: ARTHRALGIA
Synonym: ARTHRALGIAS
Synonym: Ache in joint
Synonym: Aching joints
Synonym: Arthralgia NOS
Synonym: Arthralgia NOS (finding)
Synonym: Arthralgia [Disease/Finding]
Synonym: Arthralgias
Synonym: Arthritic-like pain
Synonym: Arthrodynia
Tree Number: T3.23.10.5
database_cross_reference: AOD:0000005081
database_cross_reference: BI:BI00473
database_cross_reference: CCPSS:1015794
database_cross_reference: CHV:0000001465
database_cross_reference: COSTAR:072
database_cross_reference: COSTAR:U000004
database_cross_reference: COSTAR:U000033
database_cross_reference: COSTAR:U000034
database_cross_reference: CST:ARTHRALGIA
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000253
database_cross_reference: HPO:HP:0002829
database_cross_reference: ICD10:M25.5
database_cross_reference: ICD10AM:M25.5
database_cross_reference: ICD10AM:M25.59
database_cross_reference: ICD10CM:M25.5
database_cross_reference: ICD9CM:719.4
database_cross_reference: ICD9CM:719.40
database_cross_reference: ICPC2P:L20001
database_cross_reference: ICPC2P:L20005
database_cross_reference: LNC:MTHU013526
database_cross_reference: LNC:MTHU020863
database_cross_reference: MDR:10000449
database_cross_reference: MDR:10003239
database_cross_reference: MDR:10003245
database_cross_reference: MDR:10013088
database_cross_reference: MDR:10023197
database_cross_reference: MDR:10023222
database_cross_reference: MDR:10033434
database_cross_reference: MDR:10033444
database_cross_reference: MDR:10033456
database_cross_reference: MDR:10033511
database_cross_reference: MEDCIN:315545
database_cross_reference: MEDCIN:954
database_cross_reference: MSH:D018771
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:719.4
database_cross_reference: NCI:C50464
database_cross_reference: NCI_CTCAE:E12374
database_cross_reference: NCI_FDA:2355
database_cross_reference: NCI_NCI-GLOSS:CDR0000455150
database_cross_reference: NCI_NICHD:C50464
database_cross_reference: NDFRT:N0000003851
database_cross_reference: OMIM:MTHU000202
database_cross_reference: OMIM:MTHU002712
database_cross_reference: OMIM:MTHU011701
database_cross_reference: OMIM:MTHU013843
database_cross_reference: OMIM:MTHU017185
database_cross_reference: RCD:N094z
database_cross_reference: RCD:XE1EY
database_cross_reference: SNM:F-82600
database_cross_reference: SNMI:F-13100
database_cross_reference: SNOMEDCT_US:156592007
database_cross_reference: SNOMEDCT_US:156602008
database_cross_reference: SNOMEDCT_US:202467004
database_cross_reference: SNOMEDCT_US:202499005
database_cross_reference: SNOMEDCT_US:268065004
database_cross_reference: SNOMEDCT_US:57676002

Back pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.
MCID: MC00001462
PMOID: PMO:00014083
Subclass_of: Pain
Synonym: Ache, Back
Synonym: Aches, Back
Synonym: BACK ACHE
Synonym: BACK PAIN
Synonym: BACKACHE
Synonym: BACKPAIN
Synonym: Back Ache
Synonym: Back Aches
Synonym: Back Pain
Synonym: Back Pain [Disease/Finding]
Tree Number: T3.23.10.6
database_cross_reference: AOD:0000005113
database_cross_reference: BI:BI00483
database_cross_reference: CCPSS:1015824
database_cross_reference: CHV:0000001662
database_cross_reference: CHV:0000017620
database_cross_reference: CHV:0000050482
database_cross_reference: CHV:0000057318
database_cross_reference: COSTAR:093
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000248
database_cross_reference: CSP:2056-6005
database_cross_reference: CST:PAIN BACK
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000327
database_cross_reference: HPO:HP:0003418
database_cross_reference: ICD10:M54
database_cross_reference: ICD10:M54.9
database_cross_reference: ICD10AM:M54
database_cross_reference: ICD10AM:M54.9
database_cross_reference: ICD10CM:M54
database_cross_reference: ICD10CM:M54.9
database_cross_reference: ICD9CM:724.5
database_cross_reference: ICPC2P:L02002
database_cross_reference: ICPC2P:L02003
database_cross_reference: LCH:U000475
database_cross_reference: LCH_NW:sh85010795
database_cross_reference: LNC:MTHU020857
database_cross_reference: MDR:10003978
database_cross_reference: MDR:10003988
database_cross_reference: MDR:10003993
database_cross_reference: MDR:10003994
database_cross_reference: MDR:10013601
database_cross_reference: MDR:10033380
database_cross_reference: MDR:10033391
database_cross_reference: MDR:10033478
database_cross_reference: MDR:10064734
database_cross_reference: MEDCIN:34448
database_cross_reference: MEDCIN:362255
database_cross_reference: MEDCIN:917
database_cross_reference: MEDLINEPLUS:157
database_cross_reference: MSH:D001416
database_cross_reference: MTH:093
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C41830
database_cross_reference: NCI_CTCAE:E12388
database_cross_reference: NCI_NICHD:C41830
database_cross_reference: NDFRT:N0000000522
database_cross_reference: OMIM:MTHU009307
database_cross_reference: PSY:05275
database_cross_reference: RCD:16C..
database_cross_reference: RCD:16C2.
database_cross_reference: RCD:16CZ.
database_cross_reference: RCD:XE1FE
database_cross_reference: RCD:XM1GI
database_cross_reference: SNM:F-82600
database_cross_reference: SNMI:D1-23760
database_cross_reference: SNMI:F-16300
database_cross_reference: SNOMEDCT_US:139146005
database_cross_reference: SNOMEDCT_US:139148006
database_cross_reference: SNOMEDCT_US:139154007
database_cross_reference: SNOMEDCT_US:156651006
database_cross_reference: SNOMEDCT_US:161889002
database_cross_reference: SNOMEDCT_US:161891005

Bone pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.
MCID: MC00058241
PMOID: PMO:00014086
Subclass_of: Pain
Synonym: BONE PAIN
Synonym: Bone Pain
Synonym: Bone pain (diffuse not joint pain or arthritis)
Synonym: Bone pain (finding)
Synonym: OSTALGIA
Synonym: Ostealgia
Synonym: Osteodynia
Synonym: PAIN BONE
Synonym: Pain bone
Synonym: Pain;bone
Tree Number: T3.23.10.7
database_cross_reference: CCPSS:0024284
database_cross_reference: CCPSS:1001749
database_cross_reference: CHV:0000017079
database_cross_reference: COSTAR:U000084
database_cross_reference: CST:PAIN
database_cross_reference: CST:PAIN BONE
database_cross_reference: DXP:U000423
database_cross_reference: HPO:HP:0002653
database_cross_reference: ICPC2P:L29004
database_cross_reference: LNC:MTHU020858
database_cross_reference: MDR:10006002
database_cross_reference: MDR:10033384
database_cross_reference: MDR:10040777
database_cross_reference: MDR:10070685
database_cross_reference: MDR:10076740
database_cross_reference: MEDCIN:991
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38644
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CTCAE:E12392
database_cross_reference: OMIM:MTHU005592
database_cross_reference: RCD:X75rq
database_cross_reference: SNMI:F-12600
database_cross_reference: SNOMEDCT_US:12584003
database_cross_reference: SNOMEDCT_US:203507006

Chest pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
MCID: MC00002608
PMOID: PMO:00014087
Subclass_of: Pain
Synonym: CHEST PAIN
Synonym: Chest Pain
Synonym: Chest Pain [Disease/Finding]
Synonym: Chest Pains
Synonym: Chest pain (finding)
Synonym: Chest pain NOS
Synonym: Chest pain NOS (finding)
Synonym: Chest pain nos
Synonym: Chest pain, NOS
Synonym: Chest pain, unspecified
Tree Number: T3.23.10.8
database_cross_reference: BI:BI00012
database_cross_reference: CCPSS:1017850
database_cross_reference: CHV:0000002750
database_cross_reference: CHV:0000023593
database_cross_reference: COSTAR:171
database_cross_reference: CST:PAIN CHEST
database_cross_reference: DXP:U000673
database_cross_reference: HPO:HP:0100749
database_cross_reference: ICD10:R07.4
database_cross_reference: ICD10AM:R07.4
database_cross_reference: ICD10CM:R07.9
database_cross_reference: ICD9CM:786.5
database_cross_reference: ICD9CM:786.50
database_cross_reference: ICPC2EENG:A11
database_cross_reference: ICPC2P:A11001
database_cross_reference: ICPC2P:L04003
database_cross_reference: LCH:U000942
database_cross_reference: LCH_NW:sh85023146
database_cross_reference: LNC:LP98885-4
database_cross_reference: LNC:MTHU035552
database_cross_reference: MDR:10008479
database_cross_reference: MDR:10029524
database_cross_reference: MDR:10033387
database_cross_reference: MDR:10043471
database_cross_reference: MDR:10043492
database_cross_reference: MDR:10045653
database_cross_reference: MDR:10067524
database_cross_reference: MEDCIN:279
database_cross_reference: MEDCIN:281472
database_cross_reference: MEDCIN:33722
database_cross_reference: MEDLINEPLUS:4744
database_cross_reference: MSH:D002637
database_cross_reference: MTH:172
database_cross_reference: MTH:589
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38665
database_cross_reference: NCI_FDA:1776
database_cross_reference: NCI_NCI-GLOSS:CDR0000449748
database_cross_reference: NCI_NCI-GLOSS:CDR0000467223
database_cross_reference: NCI_NICHD:C38665
database_cross_reference: NDFRT:N0000000746
database_cross_reference: OMIM:MTHU018205
database_cross_reference: OMIM:MTHU025178
database_cross_reference: RCD:182..
database_cross_reference: RCD:182Z.
database_cross_reference: RCD:R065.
database_cross_reference: RCD:R065z
database_cross_reference: RCD:XE2rt
database_cross_reference: RCDSY:R065.
database_cross_reference: RCDSY:R065z
database_cross_reference: RCDSY:XE2rt
database_cross_reference: SNM:F-71400
database_cross_reference: SNMI:F-37000
database_cross_reference: SNOMEDCT_US:139228007
database_cross_reference: SNOMEDCT_US:139240007
database_cross_reference: SNOMEDCT_US:158393008
database_cross_reference: SNOMEDCT_US:158404009
database_cross_reference: SNOMEDCT_US:161978005
database_cross_reference: SNOMEDCT_US:207078009
database_cross_reference: SNOMEDCT_US:207079001
database_cross_reference: SNOMEDCT_US:207093008
database_cross_reference: SNOMEDCT_US:271330001
database_cross_reference: SNOMEDCT_US:29857009

Chronic pain
type: Class
subclass of: Pain
Definition: Persistent pain, usually defined as pain that has laster longer than 3 to 6 months.
MCID: MC00058028
PMOID: PMO:00014088
Subclass_of: Pain
Synonym: Chronic Pain
Synonym: Chronic Pain [Disease/Finding]
Synonym: Chronic Pains
Synonym: Chronic pain (finding)
Synonym: PAIN CHRONIC
Synonym: Pain, Chronic
Synonym: Pain;chronic
Synonym: Pains, Chronic
Synonym: chronic pain
Synonym: chronic pain (diagnosis)
Tree Number: T3.23.10.9
database_cross_reference: CCPSS:1002509
database_cross_reference: CHV:0000016768
database_cross_reference: CSP:4008-0027
database_cross_reference: HPO:HP:0012532
database_cross_reference: ICD9CM:338.2
database_cross_reference: ICPC2P:A01005
database_cross_reference: LCH_NW:sh93009482
database_cross_reference: LNC:MTHU013382
database_cross_reference: MDR:10049475
database_cross_reference: MEDCIN:311901
database_cross_reference: MEDCIN:314433
database_cross_reference: MEDLINEPLUS:5995
database_cross_reference: MSH:D059350
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26940
database_cross_reference: NCI_NCI-GLOSS:CDR0000044654
database_cross_reference: NCI_NICHD:C26940
database_cross_reference: NDFRT:N0000183371
database_cross_reference: OMIM:MTHU036441
database_cross_reference: PSY:09185
database_cross_reference: SNMI:F-A2950
database_cross_reference: SNOMEDCT_US:82423001

Costochondral pain
type: Class
subclass of: Pain
Definition: Chest wall pain in the area of the costochondral junctions.
MCID: MC01397449
PMOID: PMO:00014089
Subclass_of: Pain
Synonym: Costochondral junction pain
Tree Number: T3.23.10.10
database_cross_reference: HPO:HP:0006649

Ear pain
type: Class
subclass of: Pain
Definition: Pain in the ear can be a consequence of otologic disease (primary or otogenic otalgia), or can arise from pathologic processes and structures other than the ear (secondary or referred otalgia).
MCID: MC00004269
PMOID: PMO:00014090
Subclass_of: Pain
Synonym: (Otalgia) or (ear pain)
Synonym: (Otalgia) or (ear pain) (disorder)
Synonym: EAR PAIN
Synonym: EARACHE
Synonym: Ear Pain
Synonym: Ear ache
Synonym: Ear pain (finding)
Synonym: Earache
Synonym: Earache NOS
Synonym: Earache [Disease/Finding]
Tree Number: T3.23.10.11
database_cross_reference: CCPSS:1003417
database_cross_reference: CHV:0000004232
database_cross_reference: COSTAR:268
database_cross_reference: COSTAR:269
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:PAIN EAR
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001049
database_cross_reference: HPO:HP:0030766
database_cross_reference: ICD10:H92.0
database_cross_reference: ICD10AM:H92.0
database_cross_reference: ICD10CM:H92.0
database_cross_reference: ICD10CM:H92.09
database_cross_reference: ICD9CM:388.7
database_cross_reference: ICD9CM:388.70
database_cross_reference: ICPC2P:H01001
database_cross_reference: ICPC2P:H01002
database_cross_reference: LCH_NW:sh87007264
database_cross_reference: MDR:10013992
database_cross_reference: MDR:10014020
database_cross_reference: MDR:10014037
database_cross_reference: MDR:10031304
database_cross_reference: MDR:10031305
database_cross_reference: MDR:10033393
database_cross_reference: MDR:10033423
database_cross_reference: MEDCIN:147
database_cross_reference: MEDCIN:212827
database_cross_reference: MSH:D004433
database_cross_reference: MTH:269
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:388.70
database_cross_reference: NCI:C37944
database_cross_reference: NCI_CTCAE:E10262
database_cross_reference: NDFRT:N0000001038
database_cross_reference: RCD:1C3..
database_cross_reference: RCD:1C3Z.
database_cross_reference: RCD:F5870
database_cross_reference: RCD:F587z
database_cross_reference: RCD:XE2vk
database_cross_reference: RCD:Xa8Hm
database_cross_reference: SNM:F-X6200
database_cross_reference: SNMI:DA-90100
database_cross_reference: SNOMEDCT_US:139625000
database_cross_reference: SNOMEDCT_US:139630001
database_cross_reference: SNOMEDCT_US:155251005
database_cross_reference: SNOMEDCT_US:16001004
database_cross_reference: SNOMEDCT_US:162356005
database_cross_reference: SNOMEDCT_US:162361007
database_cross_reference: SNOMEDCT_US:194406008
database_cross_reference: SNOMEDCT_US:194407004
database_cross_reference: SNOMEDCT_US:194408009
database_cross_reference: SNOMEDCT_US:302219006

Elbow pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the elbow.
MCID: MC00081076
PMOID: PMO:00014091
Subclass_of: Pain
Synonym: ELBOW PAIN
Synonym: Pain in elbow
Synonym: Pain in elbow (finding)
Synonym: Pain in the elbows
Synonym: Pain in unspecified elbow
Synonym: Pain;elbow
Synonym: Pain;musculoskeletal;elbow
Synonym: elbow pain
Synonym: elbow pains
Synonym: elbows pain
Tree Number: T3.23.10.12
database_cross_reference: CCPSS:0058035
database_cross_reference: CHV:0000024178
database_cross_reference: DXP:U001098
database_cross_reference: HPO:HP:0030835
database_cross_reference: ICD10CM:M25.52
database_cross_reference: ICD10CM:M25.529
database_cross_reference: ICPC2P:L10001
database_cross_reference: ICPC2P:L10002
database_cross_reference: MDR:10033424
database_cross_reference: OMIM:MTHU027318
database_cross_reference: RCD:Xa35V
database_cross_reference: SNMI:F-17350
database_cross_reference: SNOMEDCT_US:74323005

Epigastric pain
type: Class
subclass of: Pain
Definition: Pain that is localized to the region of the upper abdomen immediately below the ribs.
MCID: MC00078407
PMOID: PMO:00014092
Subclass_of: Pain
Synonym: Abdmnal pain epigastric
Synonym: Abdominal pain epigastric
Synonym: Abdominal pain, epigastric
Synonym: EPIGASTRIC ABDOMINAL PAIN
Synonym: EPIGASTRIC PAIN
Synonym: Epigastralgia
Synonym: Epigastric ache
Synonym: Epigastric pain (finding)
Synonym: Epigastric pain epigastralgia
Synonym: Epigastrium pain
Tree Number: T3.23.10.13
database_cross_reference: BI:BI00241
database_cross_reference: CCPSS:1015287
database_cross_reference: CHV:0000022956
database_cross_reference: COSTAR:U000276
database_cross_reference: CST:PAIN ABDO
database_cross_reference: DXP:U001136
database_cross_reference: HPO:HP:0410019
database_cross_reference: ICD10CM:R10.13
database_cross_reference: ICD9CM:789.06
database_cross_reference: ICPC2EENG:D02
database_cross_reference: ICPC2P:D02007
database_cross_reference: ICPC2P:D02008
database_cross_reference: MDR:10015014
database_cross_reference: MDR:10015026
database_cross_reference: MDR:10015027
database_cross_reference: MDR:10033394
database_cross_reference: MDR:10048944
database_cross_reference: MEDCIN:477
database_cross_reference: OMIM:MTHU039020
database_cross_reference: RCD:1972.
database_cross_reference: RCD:R0905
database_cross_reference: RCDSY:R0905
database_cross_reference: SNMI:F-50872
database_cross_reference: SNOMEDCT_US:139318001
database_cross_reference: SNOMEDCT_US:158505007
database_cross_reference: SNOMEDCT_US:207211000
database_cross_reference: SNOMEDCT_US:79922009

Finger pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the finger.
MCID: MC00081117
PMOID: PMO:00014093
Subclass_of: Pain
Synonym: FINGER PAIN
Synonym: Finger pain (finding)
Synonym: Pain in finger
Synonym: Pain in finger (finding)
Synonym: Pain in fingers
Synonym: Pain;finger(s)
Synonym: Pain;musculoskeletal;finger(s)
Synonym: finger pain
Synonym: fingers pain
Synonym: limb pain finger
Tree Number: T3.23.10.14
database_cross_reference: CCPSS:0030607
database_cross_reference: CHV:0000024231
database_cross_reference: DXP:U001505
database_cross_reference: HPO:HP:0030837
database_cross_reference: ICPC2P:L12001
database_cross_reference: ICPC2P:L12002
database_cross_reference: MDR:10033428
database_cross_reference: MEDCIN:362297
database_cross_reference: RCD:XM1NJ
database_cross_reference: SNMI:F-176C0
database_cross_reference: SNOMEDCT_US:18876004
database_cross_reference: SNOMEDCT_US:203125007
database_cross_reference: SNOMEDCT_US:275317007

Flank pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the flank.
MCID: MC00005155
PMOID: PMO:00014094
Subclass_of: Pain
Synonym: FLANK PAIN
Synonym: Flank Pain
Synonym: Flank Pain [Disease/Finding]
Synonym: Flank Pains
Synonym: Flank pain (finding)
Synonym: PAIN FLANK
Synonym: Pain flank
Synonym: Pain, Flank
Synonym: Pain;flank
Synonym: Pains, Flank
Tree Number: T3.23.10.15
database_cross_reference: CCPSS:1017337
database_cross_reference: CHV:0000005079
database_cross_reference: COSTAR:306
database_cross_reference: CST:PAIN BACK
database_cross_reference: CST:PAIN FLANK
database_cross_reference: DXP:U001533
database_cross_reference: HPO:HP:0030157
database_cross_reference: ICPC2P:L05001
database_cross_reference: MDR:10016750
database_cross_reference: MDR:10033399
database_cross_reference: MEDCIN:558
database_cross_reference: MSH:D021501
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34615
database_cross_reference: NCI_CTCAE:E12414
database_cross_reference: NDFRT:N0000004242
database_cross_reference: OMIM:MTHU048535
database_cross_reference: RCD:X75rg
database_cross_reference: SNOMEDCT_US:139316002
database_cross_reference: SNOMEDCT_US:162045003
database_cross_reference: SNOMEDCT_US:247355005
database_cross_reference: SNOMEDCT_US:267165003

Foot pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the foot.
MCID: MC00005251
PMOID: PMO:00014095
Subclass_of: Pain
Synonym: FOOT PAIN
Synonym: Foot Pain
Synonym: Foot pain (finding)
Synonym: Hindfoot painful
Synonym: PAIN FOOT
Synonym: Pain foot
Synonym: Pain in foot
Synonym: Pain;foot/feet
Synonym: Pain;musculoskeletal;foot/feet
Synonym: Podalgia
Tree Number: T3.23.10.16
database_cross_reference: CCPSS:1017510
database_cross_reference: CHV:0000005192
database_cross_reference: COSTAR:311
database_cross_reference: CST:PAIN
database_cross_reference: DXP:U001576
database_cross_reference: HPO:HP:0025238
database_cross_reference: ICPC2P:L17001
database_cross_reference: ICPC2P:L17002
database_cross_reference: MDR:10016974
database_cross_reference: MDR:10033400
database_cross_reference: MDR:10033429
database_cross_reference: MEDCIN:362303
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34618
database_cross_reference: RCD:X75sD
database_cross_reference: SNMI:F-18A34
database_cross_reference: SNOMEDCT_US:203124006
database_cross_reference: SNOMEDCT_US:203126008
database_cross_reference: SNOMEDCT_US:389344003
database_cross_reference: SNOMEDCT_US:390077002
database_cross_reference: SNOMEDCT_US:47933007
database_cross_reference: SNOMEDCT_VET:47933007

Groin pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the groin region.
MCID: MC00081146
PMOID: PMO:00014096
Subclass_of: Pain
Synonym: GROIN PAIN
Synonym: Groin pain (finding)
Synonym: INGUINAL PAIN
Synonym: Inguinal pain
Synonym: Inguinal pain (finding)
Synonym: Inguinal region painful
Synonym: Inguinodynia
Synonym: PAIN GROIN
Synonym: Pain groin
Synonym: Pain;groin
Tree Number: T3.23.10.17
database_cross_reference: CCPSS:1011096
database_cross_reference: CHV:0000024270
database_cross_reference: CST:PAIN PELVIC
database_cross_reference: DXP:U001744
database_cross_reference: HPO:HP:0031520
database_cross_reference: ICPC2P:L14002
database_cross_reference: MDR:10018735
database_cross_reference: MDR:10033403
database_cross_reference: MDR:10077184
database_cross_reference: MEDCIN:563
database_cross_reference: RCD:R090B
database_cross_reference: RCD:XM091
database_cross_reference: RCD:Xa84t
database_cross_reference: RCDSY:R090B
database_cross_reference: SNMI:F-182A0
database_cross_reference: SNOMEDCT_US:102570003
database_cross_reference: SNOMEDCT_US:207217001
database_cross_reference: SNOMEDCT_US:271856002
database_cross_reference: SNOMEDCT_VET:102570003

Hip pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the hip.
MCID: MC00006274
PMOID: PMO:00014097
Subclass_of: Pain
Synonym: Arthralgia (hip)
Synonym: Arthralgia of hip
Synonym: Arthralgia of the hip
Synonym: Coxalgia
Synonym: HIP ARTHRALGIA
Synonym: HIP PAIN
Synonym: HIP PAIN MUSCULOSKELETAL
Synonym: Hip Pain
Synonym: Hip arthralgia
Synonym: Hip joint pain
Tree Number: T3.23.10.18
database_cross_reference: BI:BI00496
database_cross_reference: CCPSS:0041473
database_cross_reference: CCPSS:1008598
database_cross_reference: CCPSS:1017226
database_cross_reference: CHV:0000006146
database_cross_reference: COSTAR:368
database_cross_reference: DXP:U001976
database_cross_reference: HPO:HP:0003365
database_cross_reference: HPO:HP:0030838
database_cross_reference: ICD10CM:M25.55
database_cross_reference: ICD10CM:M25.559
database_cross_reference: ICPC2P:L13001
database_cross_reference: ICPC2P:L13002
database_cross_reference: LNC:MTHU020861
database_cross_reference: MDR:10011249
database_cross_reference: MDR:10033432
database_cross_reference: MDR:10033509
database_cross_reference: MEDCIN:315892
database_cross_reference: MEDCIN:943
database_cross_reference: NCI:C34699
database_cross_reference: OMIM:MTHU000886
database_cross_reference: OMIM:MTHU018890
database_cross_reference: OMIM:MTHU041420
database_cross_reference: RCD:X75rv
database_cross_reference: SNMI:F-18250
database_cross_reference: SNOMEDCT_US:156592007
database_cross_reference: SNOMEDCT_US:156598006
database_cross_reference: SNOMEDCT_US:202473003
database_cross_reference: SNOMEDCT_US:202486007
database_cross_reference: SNOMEDCT_US:268065004
database_cross_reference: SNOMEDCT_US:49218002
database_cross_reference: SNOMEDCT_VET:49218002

Jaw pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the jaw.
MCID: MC00080222
PMOID: PMO:00014098
Subclass_of: Pain
Synonym: Gnathodynia
Synonym: JAW BONE PAIN
Synonym: JAW PAIN
Synonym: Jaw bone pain
Synonym: Jaw pain (finding)
Synonym: Lower jaw pain
Synonym: MANDIBULAR PAIN
Synonym: Mandibular pain
Synonym: PAIN JAW
Synonym: Pain in jaw
Tree Number: T3.23.10.19
database_cross_reference: CCPSS:0025667
database_cross_reference: CHV:0000018291
database_cross_reference: CHV:0000023658
database_cross_reference: CST:PAIN
database_cross_reference: CST:PAIN BONE
database_cross_reference: DXP:U002205
database_cross_reference: DXP:U002501
database_cross_reference: HPO:HP:0040264
database_cross_reference: HPO:HP:0200025
database_cross_reference: ICD10CM:R68.84
database_cross_reference: ICD9CM:784.92
database_cross_reference: ICPC2P:L07001
database_cross_reference: MDR:10023143
database_cross_reference: MDR:10023157
database_cross_reference: MDR:10033433
database_cross_reference: MDR:10033455
database_cross_reference: MDR:10072238
database_cross_reference: MEDCIN:181
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:784.92
database_cross_reference: OMIM:MTHU036747
database_cross_reference: RCD:XM1B6
database_cross_reference: RCD:Xa8IQ
database_cross_reference: RCDSY:Xa8IQ
database_cross_reference: SNMI:D5-14010
database_cross_reference: SNOMEDCT_US:206948006
database_cross_reference: SNOMEDCT_US:274667000
database_cross_reference: SNOMEDCT_US:302241006
database_cross_reference: SNOMEDCT_US:95523006

Knee pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee.
MCID: MC01399424
PMOID: PMO:00014099
Subclass_of: Pain
Tree Number: T3.23.10.20
database_cross_reference: HPO:HP:0030839

Limb pain
type: Class
subclass of: Pain
Definition: Chronic pain in the limbs with no clear focal etiology.
MCID: MC00009628
PMOID: PMO:00014100
Subclass_of: Pain
Synonym: Aching in limb
Synonym: EXTREMITY PAIN
Synonym: LIMB PAIN
Synonym: Limb pain NOS
Synonym: Limb pain, NOS
Synonym: Pain in Extremity
Synonym: Pain in extremities
Synonym: Pain in extremity
Synonym: Pain in limb
Synonym: Pain in limb &/or NOS
Tree Number: T3.23.10.21
database_cross_reference: CCPSS:1015738
database_cross_reference: CHV:0000009186
database_cross_reference: COSTAR:453
database_cross_reference: DXP:U001261
database_cross_reference: HPO:HP:0009763
database_cross_reference: ICD10:M79.6
database_cross_reference: ICD10AM:M79.6
database_cross_reference: ICD10AM:M79.69
database_cross_reference: ICD10CM:M79.609
database_cross_reference: ICD9CM:729.5
database_cross_reference: ICPC2P:L29007
database_cross_reference: MDR:10000448
database_cross_reference: MDR:10033425
database_cross_reference: MDR:10033447
database_cross_reference: MDR:10033471
database_cross_reference: MDR:10033472
database_cross_reference: MEDCIN:116644
database_cross_reference: MEDCIN:335409
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78515
database_cross_reference: NCI_CTCAE:E12512
database_cross_reference: RCD:XE1Fp
database_cross_reference: RCD:Xa3h2
database_cross_reference: SNMI:D1-50740
database_cross_reference: SNOMEDCT_US:156761008
database_cross_reference: SNOMEDCT_US:156767007
database_cross_reference: SNOMEDCT_US:203124006
database_cross_reference: SNOMEDCT_US:268112008
database_cross_reference: SNOMEDCT_US:287049006
database_cross_reference: SNOMEDCT_US:90834002

Mandibular pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the mandible.
MCID: MC00080222
PMOID: PMO:00014103
Subclass_of: Pain
Synonym: Gnathodynia
Synonym: JAW BONE PAIN
Synonym: JAW PAIN
Synonym: Jaw bone pain
Synonym: Jaw pain
Synonym: Jaw pain (finding)
Synonym: Lower jaw pain
Synonym: MANDIBULAR PAIN
Synonym: PAIN JAW
Synonym: Pain in jaw
Tree Number: T3.23.10.22
database_cross_reference: CCPSS:0025667
database_cross_reference: CHV:0000018291
database_cross_reference: CHV:0000023658
database_cross_reference: CST:PAIN
database_cross_reference: CST:PAIN BONE
database_cross_reference: DXP:U002205
database_cross_reference: DXP:U002501
database_cross_reference: HPO:HP:0040264
database_cross_reference: HPO:HP:0200025
database_cross_reference: ICD10CM:R68.84
database_cross_reference: ICD9CM:784.92
database_cross_reference: ICPC2P:L07001
database_cross_reference: MDR:10023143
database_cross_reference: MDR:10023157
database_cross_reference: MDR:10033433
database_cross_reference: MDR:10033455
database_cross_reference: MDR:10072238
database_cross_reference: MEDCIN:181
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:784.92
database_cross_reference: OMIM:MTHU036747
database_cross_reference: RCD:XM1B6
database_cross_reference: RCD:Xa8IQ
database_cross_reference: RCDSY:Xa8IQ
database_cross_reference: SNMI:D5-14010
database_cross_reference: SNOMEDCT_US:206948006
database_cross_reference: SNOMEDCT_US:274667000
database_cross_reference: SNOMEDCT_US:302241006
database_cross_reference: SNOMEDCT_US:95523006

Myalgia
type: Class
subclass of: Pain
Definition: Pain in muscle.
MCID: MC00078009
PMOID: PMO:00014104
Subclass_of: Pain
Synonym: Aching muscles
Synonym: GENERALIZED MYALGIA
Synonym: Generalised muscle aches
Synonym: Generalized muscle aches
Synonym: MUSCLE ACHE
Synonym: MUSCLE DISCOMFORT
Synonym: MUSCLE PAIN
Synonym: MUSCLE PAIN GENERALIZED
Synonym: MUSCLE SORENESS
Synonym: MUSCULAR PAIN
Tree Number: T3.23.10.23
database_cross_reference: AOD:0000005145
database_cross_reference: BI:BI00501
database_cross_reference: BI:BI00506
database_cross_reference: CCPSS:0011037
database_cross_reference: CCPSS:0016545
database_cross_reference: CCPSS:1016075
database_cross_reference: CHV:0000022710
database_cross_reference: COSTAR:504
database_cross_reference: COSTAR:U000039
database_cross_reference: COSTAR:U000427
database_cross_reference: CST:MYALGIA
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001657
database_cross_reference: HPO:HP:0003326
database_cross_reference: ICD10:M79.1
database_cross_reference: ICD10AM:M79.1
database_cross_reference: ICD10CM:M79.1
database_cross_reference: ICPC2EENG:L18
database_cross_reference: ICPC2P:L18003
database_cross_reference: ICPC2P:L18006
database_cross_reference: LNC:MTHU013523
database_cross_reference: MDR:10018089
database_cross_reference: MDR:10028287
database_cross_reference: MDR:10028299
database_cross_reference: MDR:10028322
database_cross_reference: MDR:10028323
database_cross_reference: MDR:10028332
database_cross_reference: MDR:10028361
database_cross_reference: MDR:10028362
database_cross_reference: MDR:10028411
database_cross_reference: MDR:10033466
database_cross_reference: MDR:10062441
database_cross_reference: MEDCIN:1001
database_cross_reference: MEDCIN:1002
database_cross_reference: MSH:D063806
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C27009
database_cross_reference: NCI:C35785
database_cross_reference: NCI_CTCAE:E12485
database_cross_reference: NCI_FDA:2238
database_cross_reference: NCI_NCI-GLOSS:CDR0000044501
database_cross_reference: NCI_NICHD:C27009
database_cross_reference: NDFRT:N0000189366
database_cross_reference: OMIM:MTHU002772
database_cross_reference: OMIM:MTHU005259
database_cross_reference: OMIM:MTHU018310
database_cross_reference: OMIM:MTHU045047
database_cross_reference: RCD:X75rs
database_cross_reference: RCD:XE1Fm
database_cross_reference: SNM:F-82600
database_cross_reference: SNMI:F-11550
database_cross_reference: SNMI:F-11556
database_cross_reference: SNOMEDCT_US:203109002
database_cross_reference: SNOMEDCT_US:268010003
database_cross_reference: SNOMEDCT_US:268108002
database_cross_reference: SNOMEDCT_US:68962001

Neck pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the neck.
MCID: MC00002548
PMOID: PMO:00014107
Subclass_of: Pain
Synonym: (Cervicalgia) or (neck pain NOS)
Synonym: (Cervicalgia) or (neck pain NOS) (disorder)
Synonym: Ache, Neck
Synonym: Aches, Neck
Synonym: CERVICAL PAIN
Synonym: Cervical Pain
Synonym: Cervical Pains
Synonym: Cervical pain
Synonym: Cervicalgia
Synonym: Cervicalgia - pain in neck
Tree Number: T3.23.10.24
database_cross_reference: BI:BI00502
database_cross_reference: CCPSS:1015874
database_cross_reference: CHV:0000002693
database_cross_reference: COSTAR:510
database_cross_reference: CST:PAIN NECK
database_cross_reference: DXP:U000628
database_cross_reference: DXP:U002767
database_cross_reference: HPO:HP:0030833
database_cross_reference: ICD10:M54.2
database_cross_reference: ICD10AM:M54.2
database_cross_reference: ICD10CM:M54.2
database_cross_reference: ICD9CM:723.1
database_cross_reference: ICPC2P:L01004
database_cross_reference: ICPC2P:L01006
database_cross_reference: LCH_NW:sh85090564
database_cross_reference: MDR:10008296
database_cross_reference: MDR:10008322
database_cross_reference: MDR:10028836
database_cross_reference: MDR:10033467
database_cross_reference: MDR:10049860
database_cross_reference: MEDCIN:231
database_cross_reference: MEDCIN:34440
database_cross_reference: MSH:D019547
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:723.1
database_cross_reference: NCI:C50663
database_cross_reference: NCI_CTCAE:E12493
database_cross_reference: NCI_FDA:2433
database_cross_reference: NDFRT:N0000003931
database_cross_reference: OMIM:MTHU023845
database_cross_reference: RCD:XE1F4
database_cross_reference: SNMI:F-16250
database_cross_reference: SNOMEDCT_US:156641005
database_cross_reference: SNOMEDCT_US:202764005
database_cross_reference: SNOMEDCT_US:268078004
database_cross_reference: SNOMEDCT_US:81680005

Ocular pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye.
MCID: MC00058243
PMOID: PMO:00014108
Subclass_of: Pain
Synonym: EYE PAIN
Synonym: Eye Pain
Synonym: Eye Pain [Disease/Finding]
Synonym: Eye Pains
Synonym: Eye ache
Synonym: Eye pain
Synonym: Eye pain NOS
Synonym: Eye pain NOS (finding)
Synonym: Eye painful
Synonym: OCULAR PAIN
Tree Number: T3.23.10.25
database_cross_reference: CCPSS:1015742
database_cross_reference: CHV:0000017081
database_cross_reference: COSTAR:531
database_cross_reference: CST:PAIN EYE
database_cross_reference: DXP:U001322
database_cross_reference: HPO:HP:0200026
database_cross_reference: ICD10:H57.1
database_cross_reference: ICD10AM:H57.1
database_cross_reference: ICD10CM:H57.1
database_cross_reference: ICD10CM:H57.10
database_cross_reference: ICPC2EENG:F01
database_cross_reference: ICPC2P:F01001
database_cross_reference: MDR:10015906
database_cross_reference: MDR:10015958
database_cross_reference: MDR:10033397
database_cross_reference: MDR:10033426
database_cross_reference: MDR:10067261
database_cross_reference: MEDCIN:115
database_cross_reference: MSH:D058447
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78287
database_cross_reference: NCI_CTCAE:E10376
database_cross_reference: NDFRT:N0000182163
database_cross_reference: RCD:F4Kz1
database_cross_reference: RCD:X75rH
database_cross_reference: SNMI:F-F1710
database_cross_reference: SNOMEDCT_US:139556001
database_cross_reference: SNOMEDCT_US:162286001
database_cross_reference: SNOMEDCT_US:194185002
database_cross_reference: SNOMEDCT_US:41652007
database_cross_reference: SNOMEDCT_VET:41652007

Shoulder pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the shoulder.
MCID: MC01401153
PMOID: PMO:00014110
Subclass_of: Pain
Tree Number: T3.23.10.26
database_cross_reference: HPO:HP:0030834

Toe pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the toe.
MCID: MC01401517
PMOID: PMO:00014111
Subclass_of: Pain
Tree Number: T3.23.10.27
database_cross_reference: HPO:HP:0030841

Vulvodynia
type: Class
subclass of: Pain
Definition: Pain in the vulvar area
MCID: MC00142610
PMOID: PMO:00014112
Subclass_of: Pain
Synonym: Burning (of);vulva
Synonym: Burning vulva
Synonym: Vulvar pain
Synonym: Vulvodynia (disorder)
Synonym: Vulvodynia NOS
Synonym: Vulvodynia [Disease/Finding]
Synonym: Vulvodynia, unspecified
Synonym: Vulvodynias
Synonym: burning vulva
Synonym: discomfort of vulva
Tree Number: T3.23.10.28
database_cross_reference: CHV:0000023682
database_cross_reference: CHV:0000032684
database_cross_reference: HPO:HP:0030943
database_cross_reference: ICD10CM:N94.81
database_cross_reference: ICD10CM:N94.819
database_cross_reference: ICD9CM:625.7
database_cross_reference: ICD9CM:625.70
database_cross_reference: ICPC2P:X16002
database_cross_reference: LCH_NW:sh2004000507
database_cross_reference: MDR:10047781
database_cross_reference: MEDCIN:113383
database_cross_reference: MEDCIN:311473
database_cross_reference: MEDLINEPLUS:4550
database_cross_reference: MSH:D056650
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:625.70
database_cross_reference: NDFRT:N0000181144
database_cross_reference: RCD:X50GA
database_cross_reference: SNOMEDCT_US:238968009

Wrist pain
type: Class
subclass of: Pain
Definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the wrist.
MCID: MC00070941
PMOID: PMO:00014113
Subclass_of: Pain
Synonym: Ache wrists
Synonym: Arthralgia of wrist
Synonym: Pain in wrist
Synonym: Pain in wrist (finding)
Synonym: Pain;musculoskeletal;wrist
Synonym: Pain;wrist
Synonym: WRIST ARTHRALGIA
Synonym: WRIST PAIN
Synonym: Wrist arthralgia
Synonym: Wrist joint pain
Tree Number: T3.23.10.29
database_cross_reference: BI:BI00504
database_cross_reference: CCPSS:0061761
database_cross_reference: CCPSS:1016217
database_cross_reference: CHV:0000021489
database_cross_reference: CHV:0000033193
database_cross_reference: COSTAR:U000624
database_cross_reference: DXP:U004491
database_cross_reference: HPO:HP:0030836
database_cross_reference: ICD10CM:M25.53
database_cross_reference: ICPC2P:L11001
database_cross_reference: ICPC2P:L11002
database_cross_reference: MDR:10000430
database_cross_reference: MDR:10048692
database_cross_reference: MEDCIN:315886
database_cross_reference: MEDCIN:939
database_cross_reference: OMIM:MTHU016462
database_cross_reference: RCD:N094F
database_cross_reference: SNMI:F-176A0
database_cross_reference: SNOMEDCT_US:156596005
database_cross_reference: SNOMEDCT_US:202471001
database_cross_reference: SNOMEDCT_US:202482009
database_cross_reference: SNOMEDCT_US:56608008

Shivering
type: Class
subclass of: Constitutional symptom
Definition: Involuntary contraction or twitching of the muscles.
MCID: MC01401077
PMOID: PMO:00014114
Subclass_of: Constitutional symptom
Synonym: Shuddering
Tree Number: T3.23.11
database_cross_reference: HPO:HP:0025144

Growth abnormality
type: Class
subclass of: Phenotypic Abnormality
MCID: MC01398570
PMOID: PMO:00014115
Subclass_of: Phenotypic Abnormality
Synonym: Abnormal growth
Synonym: Growth issue
Tree Number: T3.24
database_cross_reference: HPO:HP:0001507

Abnormality of body height
type: Class
subclass of: Growth abnormality
Definition: Deviation from the norm of height with respect to that which is expected according to age and gender norms.
MCID: MC01003151
PMOID: PMO:00014116
Subclass_of: Growth abnormality
Tree Number: T3.24.1
database_cross_reference: HPO:HP:0000002

Abnormal upper to lower segment ratio
type: Class
subclass of: Abnormality of body height
Definition: A deviation from normal of the relation between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis.
MCID: MC01001022
PMOID: PMO:00014117
Subclass_of: Abnormality of body height
Tree Number: T3.24.1.1
database_cross_reference: HPO:HP:0012772

Short stature
type: Class
subclass of: Abnormality of body height
Definition: A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).
MCID: MC00004220
PMOID: PMO:00014120
Subclass_of: Abnormality of body height
Synonym: Constitutional dwarfism
Synonym: Constitutional short stature
Synonym: Constitutional short stature (disorder)
Synonym: DWARF
Synonym: DWARFISM
Synonym: Decreased body height
Synonym: Dwarf
Synonym: Dwarf, NOS
Synonym: Dwarfism
Synonym: Dwarfism (disorder)
Tree Number: T3.24.1.2
database_cross_reference: CCPSS:0056989
database_cross_reference: CHV:0000004192
database_cross_reference: CHV:0000037167
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2715-1516
database_cross_reference: CST:DWARFISM
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0003510
database_cross_reference: HPO:HP:0004322
database_cross_reference: ICD10CM:E34.3
database_cross_reference: ICPC2P:T80002
database_cross_reference: LCH:U001480
database_cross_reference: LCH_NW:sh85040186
database_cross_reference: MDR:10013881
database_cross_reference: MDR:10013883
database_cross_reference: MDR:10013884
database_cross_reference: MDR:10028707
database_cross_reference: MDR:10039297
database_cross_reference: MEDCIN:273623
database_cross_reference: MEDCIN:37615
database_cross_reference: MEDLINEPLUS:1244
database_cross_reference: MSH:D004392
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:259.4
database_cross_reference: NCI:C34554
database_cross_reference: NCI_NICHD:C34554
database_cross_reference: NDFRT:N0000001012
database_cross_reference: OMIM:MTHU003184
database_cross_reference: OMIM:MTHU009274
database_cross_reference: OMIM:MTHU011485
database_cross_reference: RCD:C1z41
database_cross_reference: RCD:R0346
database_cross_reference: RCD:X40Oq
database_cross_reference: RCD:X40Or
database_cross_reference: RCDSY:R0346
database_cross_reference: SNM:M-70120
database_cross_reference: SNMI:DB-00200
database_cross_reference: SNOMEDCT_US:185797004
database_cross_reference: SNOMEDCT_US:190584003
database_cross_reference: SNOMEDCT_US:190585002
database_cross_reference: SNOMEDCT_US:205467007
database_cross_reference: SNOMEDCT_US:206931003
database_cross_reference: SNOMEDCT_US:237836003
database_cross_reference: SNOMEDCT_US:237837007
database_cross_reference: SNOMEDCT_US:248299001
database_cross_reference: SNOMEDCT_US:422065006
database_cross_reference: SNOMEDCT_US:90482002
database_cross_reference: SNOMEDCT_VET:237837007

Tall stature
type: Class
subclass of: Abnormality of body height
Definition: A height above that which is expected according to age and gender norms.
MCID: MC01401401
PMOID: PMO:00014140
Subclass_of: Abnormality of body height
Synonym: Accelerated linear growth
Synonym: Increased body height
Synonym: Increased linear growth
Tree Number: T3.24.1.3
database_cross_reference: HPO:HP:0000098

Abnormality of body weight
type: Class
subclass of: Growth abnormality
Definition: An abnormal increase or decrease of weight or an abnormal distribution of mass in the body.
MCID: MC01002764
PMOID: PMO:00014145
Subclass_of: Growth abnormality
Tree Number: T3.24.2
database_cross_reference: HPO:HP:0004323

Abnormal waist to hip ratio
type: Class
subclass of: Abnormality of body weight
Definition: A deviation from normal of the waist to hip ratio, defined as the waist measurement divided by hip measurement.
MCID: MC01396225
PMOID: PMO:00014146
Subclass_of: Abnormality of body weight
Tree Number: T3.24.2.1
database_cross_reference: HPO:HP:0031818

Abnormality of body mass index
type: Class
subclass of: Abnormality of body weight
Definition: Anomaly in the weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of obesity and underweight compared to averages.
MCID: MC01396243
PMOID: PMO:00014149
Subclass_of: Abnormality of body weight
Synonym: Abnormal BMI
Synonym: Abnormal body mass index
Tree Number: T3.24.2.2
database_cross_reference: HPO:HP:0045081

Decreased body weight
type: Class
subclass of: Abnormality of body weight
MCID: MC01397510
PMOID: PMO:00014151
Subclass_of: Abnormality of body weight
Synonym: Decreased weight
Synonym: Low body weight
Synonym: Low weight
Synonym: Weight less than 3rd percentile
Tree Number: T3.24.2.3
database_cross_reference: HPO:HP:0004325

Increased body weight
type: Class
subclass of: Abnormality of body weight
Definition: Abnormally increased body weight.
MCID: MC01399026
PMOID: PMO:00014161
Subclass_of: Abnormality of body weight
Tree Number: T3.24.2.4
database_cross_reference: HPO:HP:0004324

Asymmetric growth
type: Class
subclass of: Growth abnormality
Definition: A growth pattern that displays an abnormal difference between the left and the right side.
MCID: MC01396962
PMOID: PMO:00014171
Subclass_of: Growth abnormality
Synonym: Uneven or disproportionate growth of one body part compared to another
Tree Number: T3.24.3
database_cross_reference: HPO:HP:0100555

Growth delay
type: Class
subclass of: Growth abnormality
Definition: A deficiency or slowing down of growth pre- and postnatally.
MCID: MC00150910
PMOID: PMO:00014172
Subclass_of: Growth abnormality
Synonym: Delayed growth
Synonym: Delayed;growth
Synonym: Growth deficiency
Synonym: Growth delay (disorder)
Synonym: delay growth
Synonym: delayed disorder growth
Synonym: delayed growth
Synonym: delays growth
Synonym: growth delay
Tree Number: T3.24.4
database_cross_reference: CHV:0000036549
database_cross_reference: HPO:HP:0001510
database_cross_reference: ICPC2EENG:T10
database_cross_reference: ICPC2P:T10013
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU002219
database_cross_reference: OMIM:MTHU006431
database_cross_reference: OMIM:MTHU045544
database_cross_reference: RCD:Xa09f
database_cross_reference: SNOMEDCT_US:276617005

Absent pubertal growth spurt
type: Class
subclass of: Growth delay
Definition: The abrupt and transient increase in the annual growth rate normally observed in adolescent individuals does not occur.
MCID: MC01396541
PMOID: PMO:00014173
Subclass_of: Growth delay
Synonym: Absent adolescent growth spurt
Tree Number: T3.24.4.1
database_cross_reference: HPO:HP:0031087

Intrauterine growth retardation
type: Class
subclass of: Growth delay
Definition: An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.
MCID: MC00005073
PMOID: PMO:00014174
Subclass_of: Growth delay
Synonym: (Fetal growth retardation NOS) or (intrauterine growth retardation)
Synonym: (Fetal growth retardation NOS) or (intrauterine growth retardation) (disorder)
Synonym: FGR - Fetal growth retardation
Synonym: FGR - Foetal growth retardation
Synonym: Fet growth retard wtNOS
Synonym: Fetal Growth Retardation
Synonym: Fetal Growth Retardation [Disease/Finding]
Synonym: Fetal growth restriction
Synonym: Fetal growth retardation
Synonym: Fetal growth retardation (disorder)
Tree Number: T3.24.4.2
database_cross_reference: CCPSS:1013735
database_cross_reference: CHV:0000004992
database_cross_reference: CSP:2403-8925
database_cross_reference: HPO:HP:0001511
database_cross_reference: ICD10:P05.9
database_cross_reference: ICD10AM:P05.9
database_cross_reference: ICD9CM:764.9
database_cross_reference: ICD9CM:764.90
database_cross_reference: ICPC2P:W84015
database_cross_reference: LCH_NW:sh85047972
database_cross_reference: MDR:10016497
database_cross_reference: MDR:10016498
database_cross_reference: MDR:10016857
database_cross_reference: MDR:10022819
database_cross_reference: MDR:10048488
database_cross_reference: MDR:10048489
database_cross_reference: MDR:10054746
database_cross_reference: MDR:10055695
database_cross_reference: MDR:10055696
database_cross_reference: MDR:10070531
database_cross_reference: MDR:10070532
database_cross_reference: MDR:10071034
database_cross_reference: MEDCIN:35631
database_cross_reference: MSH:D005317
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:764.9
database_cross_reference: MTHICD9:764.90
database_cross_reference: NDFRT:N0000001235
database_cross_reference: OMIM:MTHU001305
database_cross_reference: OMIM:MTHU001437
database_cross_reference: OMIM:MTHU004084
database_cross_reference: OMIM:MTHU008018
database_cross_reference: OMIM:MTHU010681
database_cross_reference: OMIM:MTHU012015
database_cross_reference: OMIM:MTHU020425
database_cross_reference: OMIM:MTHU022021
database_cross_reference: OMIM:MTHU022541
database_cross_reference: OMIM:MTHU036654
database_cross_reference: OMIM:MTHU040979
database_cross_reference: RCD:X70Er
database_cross_reference: RCD:XE1eV
database_cross_reference: SNM:F-33710
database_cross_reference: SNMI:D8-70110
database_cross_reference: SNOMEDCT_US:156185006
database_cross_reference: SNOMEDCT_US:206166000
database_cross_reference: SNOMEDCT_US:22033007
database_cross_reference: SNOMEDCT_US:267337006
database_cross_reference: SNOMEDCT_US:268815007

Postnatal growth retardation
type: Class
subclass of: Growth delay
Definition: Slow or limited growth after birth.
MCID: MC01400505
PMOID: PMO:00014178
Subclass_of: Growth delay
Synonym: Growth delay as children
Synonym: Growth retardation as children
Synonym: Postnatal growth deceleration
Synonym: Postnatal growth deficiency
Synonym: Postnatal growth failure
Tree Number: T3.24.4.3
database_cross_reference: HPO:HP:0008897

Heterotaxy
type: Class
subclass of: Growth abnormality
Definition: An abnormality in which the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body.
MCID: MC00091267
PMOID: PMO:00014182
Subclass_of: Growth abnormality
Synonym: Ambiguus Viscerum, Situs
Synonym: Ambiguus Viscerums, Situs
Synonym: Ambiguus, Situs
Synonym: Heterotaxia
Synonym: Heterotaxies, Visceral
Synonym: Heterotaxis
Synonym: Heterotaxy, Visceral
Synonym: Isomerism sequence
Synonym: Laterality sequence
Synonym: Laterality sequence (disorder)
Tree Number: T3.24.5
database_cross_reference: CHV:0000011378
database_cross_reference: HPO:HP:0001696
database_cross_reference: HPO:HP:0030853
database_cross_reference: JABL:341
database_cross_reference: MDR:10067265
database_cross_reference: MSH:D059446
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87083
database_cross_reference: NCI_NICHD:C87083
database_cross_reference: OMIM:MTHU043055
database_cross_reference: SNM:M-22120
database_cross_reference: SNMI:D4-01510
database_cross_reference: SNMI:D4-D0050
database_cross_reference: SNOMEDCT_US:14821001
database_cross_reference: SNOMEDCT_US:24614000

Abnormality of abdominal situs
type: Class
subclass of: Heterotaxy
Definition: An abnormality of the abdominal situs, i.e., of the sidedness of the abdomen and its organs.
MCID: MC01001325
PMOID: PMO:00014183
Subclass_of: Heterotaxy
Tree Number: T3.24.5.1
database_cross_reference: HPO:HP:0011620

Isomerism
type: Class
subclass of: Heterotaxy
Definition: Isomerism in the context of the congenitally malformed heart is defined as a situation where some paired structures on opposite sides of the left-right axis of the body are, in morphologic terms, symmetrical mirror images of each other.
MCID: MC01399389
PMOID: PMO:00014186
Subclass_of: Heterotaxy
Tree Number: T3.24.5.2
database_cross_reference: HPO:HP:0031853

Increased body fat percentage
type: Class
subclass of: Growth abnormality
Definition: The percentage of fat as a part of total body weight above the norm, usually defined as 32% for females and 25% for males.
MCID: MC01399024
PMOID: PMO:00014190
Subclass_of: Growth abnormality
Tree Number: T3.24.6
database_cross_reference: HPO:HP:0025521

Neoplasm
type: Class
subclass of: Phenotypic Abnormality
Definition: An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumour).
MCID: MC00008730
PMOID: PMO:00014191
Subclass_of: Phenotypic Abnormality
Synonym: 800 NEOPLASMS, NOS
Synonym: NEOPL
Synonym: NEOPLASIA
Synonym: NEOPLASM
Synonym: NEOPLASM (NOS)
Synonym: NEOPLASM NOS
Synonym: NEOPLASMS
Synonym: NEOPLASMS, NOS
Synonym: NG - Neoplastic growth
Synonym: NG - New growth
Tree Number: T3.25
database_cross_reference: AOD:0000004514
database_cross_reference: AOD:0000004515
database_cross_reference: AOD:0000007366
database_cross_reference: AOD:0000023007
database_cross_reference: CCPSS:1010221
database_cross_reference: CCPSS:1013404
database_cross_reference: CHV:0000008566
database_cross_reference: COSTAR:755
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2000-0173
database_cross_reference: CSP:2029-2915
database_cross_reference: CST:NEOPL
database_cross_reference: HPO:HP:0002664
database_cross_reference: ICD10:C00-D48.9
database_cross_reference: ICD10AM:C00-D48.9
database_cross_reference: ICD10CM:D49
database_cross_reference: ICD9CM:140-239.99
database_cross_reference: ICPC2P:A79002
database_cross_reference: LCH:U005814
database_cross_reference: LCH_NW:sh85138553
database_cross_reference: LNC:LA16304-0
database_cross_reference: LNC:LP207120-9
database_cross_reference: LNC:LP7664-8
database_cross_reference: LNC:MTHU010346
database_cross_reference: MDR:10028980
database_cross_reference: MDR:10029000
database_cross_reference: MDR:10029104
database_cross_reference: MDR:10048524
database_cross_reference: MEDCIN:363344
database_cross_reference: MEDLINEPLUS:25
database_cross_reference: MSH:D009369
database_cross_reference: MTH:471
database_cross_reference: MTH:755
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3262
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000045801
database_cross_reference: NCI_NCI-GLOSS:CDR0000046264
database_cross_reference: NCI_NCI-GLOSS:CDR0000046634
database_cross_reference: NCI_NICHD:C3262
database_cross_reference: NDFRT:N0000002128
database_cross_reference: OMIM:MTHU000126
database_cross_reference: PSY:33370
database_cross_reference: PSY:54430
database_cross_reference: RCD:BB0..
database_cross_reference: RCD:Bz...
database_cross_reference: RCD:XE1vN
database_cross_reference: RCDAE:Bz...
database_cross_reference: RCDAE:XE1vN
database_cross_reference: RCDSY:BB0..
database_cross_reference: SNM:M-8000/1
database_cross_reference: SNM:U000390
database_cross_reference: SNMI:M-80000
database_cross_reference: SNMI:M-80001
database_cross_reference: SNOMEDCT_US:108369006
database_cross_reference: SNOMEDCT_US:154634001
database_cross_reference: SNOMEDCT_US:154645003
database_cross_reference: SNOMEDCT_US:154646002
database_cross_reference: SNOMEDCT_US:187597000
database_cross_reference: SNOMEDCT_US:189542002
database_cross_reference: SNOMEDCT_US:190230000
database_cross_reference: SNOMEDCT_US:86251006

Neoplasm by anatomical site
type: Class
subclass of: Neoplasm
Definition: Neoplasm categorized according to the anatomical site of origin of the neoplasm.
MCID: MC01001255
PMOID: PMO:00014192
Subclass_of: Neoplasm
Tree Number: T3.25.1
database_cross_reference: HPO:HP:0011793

Malignant mesothelioma
type: Class
subclass of: Neoplasm by anatomical site
Definition: Malignant mesothelioma is a form of cancer that originates from the cells of the mesothelium, a thin tissue layer surrounding the body's internal organs. Malignant mesothelioma is almost exclusively caused by asbestos exposure, pleural mesothelioma beeing the most common form, affecting the lining of the lungs called the pleura. Other forms such as perioneal-, percardial- or testicular- mesothelioma are much rarer.
MCID: MC00122729
PMOID: PMO:00014193
Subclass_of: Neoplasm by anatomical site
Synonym: Cancer, mesothelioma
Synonym: MESOM
Synonym: MESOTHELIOMA, MALIGNANT
Synonym: Malignant Mesothelial Neoplasm
Synonym: Malignant Mesothelial Tumor
Synonym: Malignant Mesothelioma
Synonym: Malignant Neoplasm of Mesothelium
Synonym: Malignant Neoplasm of the Mesothelium
Synonym: Malignant Tumor of Mesothelium
Synonym: Malignant Tumor of the Mesothelium
Tree Number: T3.25.1.1
database_cross_reference: CHV:0000031033
database_cross_reference: HPO:HP:0100001
database_cross_reference: ICD10AM:M9050/3
database_cross_reference: MDR:10027407
database_cross_reference: MDR:10027410
database_cross_reference: MEDCIN:335197
database_cross_reference: MEDLINEPLUS:4014
database_cross_reference: MSH:C562839
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4456
database_cross_reference: NCI_CDISC:C4456
database_cross_reference: NCI_NCI-GLOSS:CDR0000044992
database_cross_reference: OMIM:156240
database_cross_reference: OMIM:MTHU053483
database_cross_reference: PDQ:CDR0000038142
database_cross_reference: RCD:BBP1.
database_cross_reference: SNM:M-9050/3
database_cross_reference: SNMI:M-90503
database_cross_reference: SNOMEDCT_US:109378008
database_cross_reference: SNOMEDCT_US:62064005
database_cross_reference: SNOMEDCT_VET:109378008

Neoplasm of head and neck
type: Class
subclass of: Neoplasm by anatomical site
Definition: A tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx.
MCID: MC00005962
PMOID: PMO:00014197
Subclass_of: Neoplasm by anatomical site
Synonym: HEAD NECK NEOPL
Synonym: Head and Neck Neoplasm
Synonym: Head and Neck Neoplasm (Excluding Central Nervous System)
Synonym: Head and Neck Neoplasms
Synonym: Head and Neck Neoplasms [Disease/Finding]
Synonym: Head and Neck Tumor
Synonym: Head and neck tumor
Synonym: Head, Neck Neoplasms
Synonym: NEOPL HEAD NECK
Synonym: Neoplasm of Head and Neck
Tree Number: T3.25.1.2
database_cross_reference: AOD:0000023037
database_cross_reference: CHV:0000005815
database_cross_reference: CSP:2005-4325
database_cross_reference: DO:DOID:11934
database_cross_reference: HPO:HP:0012288
database_cross_reference: MSH:D006258
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3077
database_cross_reference: NCI:TCGA
database_cross_reference: NDFRT:N0000001416
database_cross_reference: RCD:X78eD
database_cross_reference: RCDAE:X78eD
database_cross_reference: SNOMEDCT_US:255055008

Neoplasm of striated muscle
type: Class
subclass of: Neoplasm by anatomical site
Definition: A benign or malignant neoplasm (tumour) originating in striated muscle, either skeletal muscle or cardiac muscle.
MCID: MC01000055
PMOID: PMO:00014202
Subclass_of: Neoplasm by anatomical site
Synonym: Tumors of striated muscle
Tree Number: T3.25.1.3
database_cross_reference: HPO:HP:0009728

Neoplasm of the breast
type: Class
subclass of: Neoplasm by anatomical site
Definition: A tumor (abnormal growth of tissue) of the breast.
MCID: MC00520446
PMOID: PMO:00014207
Subclass_of: Neoplasm by anatomical site
Synonym: BREAST NEOPL
Synonym: BREAST NEOPLASM
Synonym: Breast Neoplasm
Synonym: Breast Neoplasms
Synonym: Breast Neoplasms [Disease/Finding]
Synonym: Breast Tumor
Synonym: Breast Tumors
Synonym: Breast neoplasm
Synonym: Breast neoplasm NOS
Synonym: Breast tumor
Tree Number: T3.25.1.4
database_cross_reference: AOD:0000023048
database_cross_reference: AOD:0000023049
database_cross_reference: CHV:0000002156
database_cross_reference: COSTAR:U000090
database_cross_reference: CSP:2001-3195
database_cross_reference: CSP:2016-0671
database_cross_reference: CST:NEOPL BREAST
database_cross_reference: HPO:HP:0100013
database_cross_reference: LCH_NW:sh85016690
database_cross_reference: LNC:LP36755-4
database_cross_reference: LNC:MTHU019437
database_cross_reference: MDR:10006279
database_cross_reference: MDR:10006285
database_cross_reference: MDR:10028985
database_cross_reference: MEDCIN:31643
database_cross_reference: MEDCIN:39311
database_cross_reference: MSH:D001943
database_cross_reference: MTH:120
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2910
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_FDA:2438
database_cross_reference: NDFRT:N0000000612
database_cross_reference: PSY:06940
database_cross_reference: PSY:29330
database_cross_reference: RCD:X40G6
database_cross_reference: RCDAE:X40G6
database_cross_reference: SNOMEDCT_US:126926005

Neoplasm of the eye
type: Class
subclass of: Neoplasm by anatomical site
Definition: A tumor (abnormal growth of tissue) of the eye.
MCID: MC00004907
PMOID: PMO:00014213
Subclass_of: Neoplasm by anatomical site
Synonym: EYE NEOPL
Synonym: Eye Neoplasm
Synonym: Eye Neoplasms
Synonym: Eye Neoplasms [Disease/Finding]
Synonym: Eye Tumor
Synonym: Eye tumor
Synonym: Eye--Tumors
Synonym: NEOPL EYE
Synonym: Neoplasia of the eye
Synonym: Neoplasm eye NOS
Tree Number: T3.25.1.5
database_cross_reference: CHV:0000004829
database_cross_reference: CSP:2018-3273
database_cross_reference: DO:DOID:2174
database_cross_reference: HPO:HP:0100012
database_cross_reference: ICPC2P:F74004
database_cross_reference: LCH_NW:sh85046682
database_cross_reference: MDR:10030054
database_cross_reference: MDR:10048730
database_cross_reference: MDR:10052448
database_cross_reference: MEDCIN:34022
database_cross_reference: MEDCIN:34023
database_cross_reference: MSH:D005134
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3030
database_cross_reference: NDFRT:N0000001186
database_cross_reference: RCD:X78ax
database_cross_reference: RCDAE:X78ax
database_cross_reference: SNOMEDCT_US:126995000
database_cross_reference: SNOMEDCT_US:371486001

Neoplasm of the lip
type: Class
subclass of: Neoplasm by anatomical site
Definition: A tumor (abnormal growth of tissue) of the lip.
MCID: MC00007584
PMOID: PMO:00014218
Subclass_of: Neoplasm by anatomical site
Synonym: LIP NEOPL
Synonym: Lip Neoplasm
Synonym: Lip Neoplasms
Synonym: Lip Neoplasms [Disease/Finding]
Synonym: Lip Tumor
Synonym: Lip neoplasm
Synonym: Lip neoplasm NOS
Synonym: Lip tumor
Synonym: Lips--Tumors
Synonym: NEOPL LIP
Tree Number: T3.25.1.6
database_cross_reference: CHV:0000007448
database_cross_reference: HPO:HP:0100604
database_cross_reference: LCH_NW:sh85077324
database_cross_reference: MDR:10049549
database_cross_reference: MDR:10062038
database_cross_reference: MEDCIN:35228
database_cross_reference: MSH:D008048
database_cross_reference: NCI:C3191
database_cross_reference: NDFRT:N0000001847
database_cross_reference: RCD:X20TR
database_cross_reference: RCDAE:X20TR
database_cross_reference: SNOMEDCT_US:126770008

Neoplasm of the oral cavity
type: Class
subclass of: Neoplasm by anatomical site
Definition: A tumor (abnormal growth of tissue) of the oral cavity.
MCID: MC00008435
PMOID: PMO:00014219
Subclass_of: Neoplasm by anatomical site
Synonym: Lip and Oral Cavity Neoplasm
Synonym: Lip and Oral Cavity Tumor
Synonym: Lip and Oral Cavity Tumour
Synonym: MOUTH NEOPL
Synonym: MOUTH NEOPLASIA
Synonym: MOUTH TUMOR
Synonym: Mouth Neoplasm
Synonym: Mouth Neoplasms
Synonym: Mouth Neoplasms [Disease/Finding]
Synonym: Mouth Tumor
Tree Number: T3.25.1.7
database_cross_reference: AOD:0000023042
database_cross_reference: AOD:0000023043
database_cross_reference: AOD:0000023044
database_cross_reference: CHV:0000008288
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2013-2197
database_cross_reference: CST:NEOPL MOUTH
database_cross_reference: DXP:U002644
database_cross_reference: HPO:HP:0012290
database_cross_reference: HPO:HP:0100649
database_cross_reference: LCH_NW:sh85088004
database_cross_reference: MDR:10028029
database_cross_reference: MDR:10028999
database_cross_reference: MDR:10029001
database_cross_reference: MDR:10031008
database_cross_reference: MDR:10061325
database_cross_reference: MEDCIN:97905
database_cross_reference: MSH:D009062
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C7606
database_cross_reference: NCI:C8989
database_cross_reference: NDFRT:N0000002037
database_cross_reference: RCD:X20Rh
database_cross_reference: RCDAE:X20Rh
database_cross_reference: SNOMEDCT_US:126797001
database_cross_reference: SNOMEDCT_US:235075007
database_cross_reference: SNOMEDCT_VET:235075007

Neoplasm of the pancreas
type: Class
subclass of: Neoplasm by anatomical site
Definition: A tumor (abnormal growth of tissue) of the pancreas.
MCID: MC00009664
PMOID: PMO:00014231
Subclass_of: Neoplasm by anatomical site
Synonym: Ca body of pancreas
Synonym: Ca head of pancreas
Synonym: Ca tail of pancreas
Synonym: NEOPL PANCREATIC
Synonym: Neoplasia of the pancreas
Synonym: Neoplasm of Pancreas
Synonym: Neoplasm of pancreas
Synonym: Neoplasm of pancreas (disorder)
Synonym: Neoplasm of the Pancreas
Synonym: Neoplasm, Pancreas
Tree Number: T3.25.1.8
database_cross_reference: AOD:0000023068
database_cross_reference: AOD:0000023069
database_cross_reference: CCPSS:0044979
database_cross_reference: CHV:0000009225
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2014-4876
database_cross_reference: DO:DOID:1793
database_cross_reference: HPO:HP:0002894
database_cross_reference: LCH_NW:sh85097380
database_cross_reference: MDR:10033632
database_cross_reference: MDR:10049099
database_cross_reference: MDR:10050255
database_cross_reference: MDR:10061902
database_cross_reference: MEDCIN:31624
database_cross_reference: MSH:D010190
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3305
database_cross_reference: NDFRT:N0000002288
database_cross_reference: RCD:X309Y
database_cross_reference: RCDAE:X309Y
database_cross_reference: SNOMEDCT_US:126859007

Neoplasm of the respiratory system
type: Class
subclass of: Neoplasm by anatomical site
Definition: A tumor (abnormal growth of tissue) of the respiratory system.
MCID: MC00011286
PMOID: PMO:00014238
Subclass_of: Neoplasm by anatomical site
Synonym: Neoplasm of Respiratory Tract
Synonym: Neoplasm of respiratory system
Synonym: Neoplasm of respiratory system (disorder)
Synonym: Neoplasm of respiratory tract
Synonym: Neoplasm of respiratory tract (disorder)
Synonym: Neoplasm of the Respiratory Tract
Synonym: Neoplasm, Respiratory Tract
Synonym: Neoplasm;respiratory
Synonym: Neoplasms, Respiratory Tract
Synonym: RESPIRATORY TRACT NEOPL
Tree Number: T3.25.1.9
database_cross_reference: AOD:0000023031
database_cross_reference: CHV:0000010771
database_cross_reference: CSP:2017-5336
database_cross_reference: HPO:HP:0100606
database_cross_reference: ICPC2P:R86005
database_cross_reference: ICPC2P:R92003
database_cross_reference: MDR:10029107
database_cross_reference: MDR:10038735
database_cross_reference: MDR:10061486
database_cross_reference: MSH:D012142
database_cross_reference: NCI:C3355
database_cross_reference: NDFRT:N0000002604
database_cross_reference: SNOMEDCT_US:126667002
database_cross_reference: SNOMEDCT_US:448708002

Neoplasm of the skeletal system
type: Class
subclass of: Neoplasm by anatomical site
Definition: A tumor (abnormal growth of tissue) of the skeleton.
MCID: MC00753697
PMOID: PMO:00014241
Subclass_of: Neoplasm by anatomical site
Synonym: Neoplasm of skeletal system
Synonym: Neoplasm of skeletal system (disorder)
Synonym: Skeletal tumor
Synonym: neoplasm of skeletal system (diagnosis)
Tree Number: T3.25.1.10
database_cross_reference: HPO:HP:0010622
database_cross_reference: MEDCIN:355858
database_cross_reference: SNOMEDCT_US:442868003

Retroperitoneal chemodectomas
type: Class
subclass of: Neoplasm by anatomical site
MCID: MC01002525
PMOID: PMO:00014264
Subclass_of: Neoplasm by anatomical site
Tree Number: T3.25.1.11
database_cross_reference: HPO:HP:0006729

Soft tissue neoplasm
type: Class
subclass of: Neoplasm by anatomical site
Definition: A tumor (abnormal growth of tissue) that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms.
MCID: MC00012031
PMOID: PMO:00014265
Subclass_of: Neoplasm by anatomical site
Synonym: Neoplasm of Soft Tissue
Synonym: Neoplasm of soft tissue
Synonym: Neoplasm of soft tissue (disorder)
Synonym: Neoplasm of soft tissues
Synonym: Neoplasm of soft tissues (disorder)
Synonym: Neoplasm of the Soft Tissue
Synonym: Neoplasm, Soft Tissue
Synonym: Neoplasms, Soft Tissue
Synonym: SOFT TISSUE NEOPL
Synonym: SOFT TISSUE TUMOR
Tree Number: T3.25.1.12
database_cross_reference: CCPSS:0054044
database_cross_reference: CHV:0000011508
database_cross_reference: DO:DOID:0060123
database_cross_reference: HPO:HP:0031459
database_cross_reference: LCH_NW:sh91000905
database_cross_reference: MDR:10068771
database_cross_reference: MEDCIN:90412
database_cross_reference: MSH:D012983
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3377
database_cross_reference: NCI_CTEP-SDC:10061271
database_cross_reference: NDFRT:N0000002780
database_cross_reference: RCD:Xa0Pj
database_cross_reference: RCDAE:Xa0Pj
database_cross_reference: SNOMEDCT_US:126600002
database_cross_reference: SNOMEDCT_US:387837005

Vascular neoplasm
type: Class
subclass of: Neoplasm by anatomical site
Definition: A benign or malignant neoplasm (tumour) originating in the vascular system.
MCID: MC00099017
PMOID: PMO:00014269
Subclass_of: Neoplasm by anatomical site
Synonym: Blood Vessel neoplasm
Synonym: Blood vessel tumor
Synonym: Blood vessel tumors
Synonym: Blood vessel tumour disorder
Synonym: Haemangiomatous tumour
Synonym: NEOPL VASCULAR
Synonym: Neoplasm of Vascular Tissue
Synonym: Neoplasm, Vascular
Synonym: Neoplasms, Vascular
Synonym: Tumor of Vascular Tissue
Tree Number: T3.25.1.13
database_cross_reference: CHV:0000027665
database_cross_reference: DO:DOID:175
database_cross_reference: HPO:HP:0100742
database_cross_reference: MDR:10055031
database_cross_reference: MDR:10057189
database_cross_reference: MSH:D019043
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C7388
database_cross_reference: NCI_CTEP-SDC:10055031
database_cross_reference: NDFRT:N0000003887

Neoplasm by histology
type: Class
subclass of: Neoplasm
Definition: Neoplasm categorized according to type of histological abnormality.
MCID: MC01001256
PMOID: PMO:00014292
Subclass_of: Neoplasm
Tree Number: T3.25.2
database_cross_reference: HPO:HP:0011792

Embryonal neoplasm
type: Class
subclass of: Neoplasm by histology
MCID: MC00008733
PMOID: PMO:00014293
Subclass_of: Neoplasm by histology
Synonym: EMBRYONAL NEOPL
Synonym: Embryonal Neoplasm
Synonym: Embryonal Neoplasms
Synonym: Embryonal neoplasia
Synonym: Embryonal tumors
Synonym: NEOPL EMBRYONAL
Synonym: Neoplasm, Embryonal
Synonym: Neoplasms, Embryonal
Synonym: Tumors, Embryonal
Synonym: embryo cancer
Tree Number: T3.25.2.1
database_cross_reference: AOD:0000004545
database_cross_reference: AOD:0000023019
database_cross_reference: CSP:2000-3997
database_cross_reference: DO:DOID:688
database_cross_reference: HPO:HP:0002898
database_cross_reference: LCH:U005815
database_cross_reference: LCH_NW:sh85138564
database_cross_reference: MSH:D009373
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3264
database_cross_reference: NCI_NCI-GLOSS:CDR0000367442
database_cross_reference: OMIM:MTHU006872

Epithelial neoplasm
type: Class
subclass of: Neoplasm by histology
Definition: A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas [NCIT:C3709].
MCID: MC00468320
PMOID: PMO:00014307
Subclass_of: Neoplasm by histology
Synonym: 801-804 EPITHELIAL NEOPLASMS, NOS
Synonym: EPITHELIAL NEOPL
Synonym: EPITHELIAL NEOPLASMS, NOS
Synonym: Epithelial Neoplasm
Synonym: Epithelial Neoplasms
Synonym: Epithelial Neoplasms, NOS
Synonym: Epithelial neoplasm (morphologic abnormality)
Synonym: Epithelial neoplasms NOS
Synonym: Epithelial tumor
Synonym: Epithelial tumor (qualifier value)
Tree Number: T3.25.2.2
database_cross_reference: AOD:0000004523
database_cross_reference: AOD:0000023017
database_cross_reference: CHV:0000020733
database_cross_reference: CSP:2000-5801
database_cross_reference: HPO:HP:0031492
database_cross_reference: ICPC2P:R85007
database_cross_reference: ICPC2P:R92002
database_cross_reference: MDR:10015105
database_cross_reference: MSH:D009375
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3709
database_cross_reference: OMIM:MTHU013710
database_cross_reference: RCD:BB1..
database_cross_reference: RCD:BB1z.
database_cross_reference: RCD:X77mu
database_cross_reference: RCDAE:X77mu
database_cross_reference: RCDSY:BB1..
database_cross_reference: RCDSY:BB1z.
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:M-80100
database_cross_reference: SNOMEDCT_US:118285006
database_cross_reference: SNOMEDCT_US:134207000
database_cross_reference: SNOMEDCT_US:188083002
database_cross_reference: SNOMEDCT_US:189546004
database_cross_reference: SNOMEDCT_US:189559007
database_cross_reference: SNOMEDCT_VET:45741000009101

Fibrous tissue neoplasm
type: Class
subclass of: Neoplasm by histology
Definition: Any neoplasm composed of fibrous tissue.
MCID: MC00005116
PMOID: PMO:00014316
Subclass_of: Neoplasm by histology
Synonym: FIBROSARCOMA
Synonym: FIBROSARCOMA, MALIGNANT
Synonym: Fibrocytic tumor
Synonym: Fibrosarcoma
Synonym: Fibrosarcoma (disorder)
Synonym: Fibrosarcoma (excluding infantile fibrosarcoma)
Synonym: Fibrosarcoma (morphologic abnormality)
Synonym: Fibrosarcoma - not infantile
Synonym: Fibrosarcoma NOS
Synonym: Fibrosarcoma [Disease/Finding]
Tree Number: T3.25.2.3
database_cross_reference: AOD:0000004531
database_cross_reference: CCPSS:0056525
database_cross_reference: CHV:0000005036
database_cross_reference: COSTAR:U000290
database_cross_reference: CSP:2000-6227
database_cross_reference: DO:DOID:3355
database_cross_reference: DXP:U000648
database_cross_reference: HPO:HP:0100244
database_cross_reference: ICD10AM:M8810/3
database_cross_reference: ICPC2P:L71017
database_cross_reference: MDR:10016632
database_cross_reference: MDR:10016634
database_cross_reference: MDR:10016637
database_cross_reference: MEDCIN:271507
database_cross_reference: MSH:D005354
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3043
database_cross_reference: NCI_CDISC:C3043
database_cross_reference: NCI_CTEP-SDC:10016637
database_cross_reference: NCI_NCI-GLOSS:CDR0000046403
database_cross_reference: NCI_NICHD:C3043
database_cross_reference: NDFRT:N0000001248
database_cross_reference: OMIM:MTHU016126
database_cross_reference: RCD:BBG1.
database_cross_reference: RCDSY:BBG1.
database_cross_reference: SNM:M-8810/3
database_cross_reference: SNMI:M-88103
database_cross_reference: SNOMEDCT_US:443250000
database_cross_reference: SNOMEDCT_US:53654007
database_cross_reference: SNOMEDCT_VET:309521000009107

Hamartoma
type: Class
subclass of: Neoplasm by histology
Definition: A disordered proliferation of mature tissues that is native to the site of origin, e.g., exostoses, nevi and soft tissue hamartomas. Although most hamartomas are benign, some histologic subtypes, e.g., neuromuscular hamartoma, may proliferate aggressively such as mesenchymal cystic hamartoma, Sclerosing epithelial hamartoma, Sclerosing metanephric hamartoma.
MCID: MC00005934
PMOID: PMO:00014319
Subclass_of: Neoplasm by histology
Synonym: 755-756 HAMARTOMAS
Synonym: HAMARTOMA
Synonym: HAMARTOMAS
Synonym: Hamartoma (disorder)
Synonym: Hamartoma (morphologic abnormality)
Synonym: Hamartoma NOS
Synonym: Hamartoma [Disease/Finding]
Synonym: Hamartoma, NOS
Synonym: Hamartomas
Synonym: Hamartomatous
Tree Number: T3.25.2.4
database_cross_reference: CCPSS:0053735
database_cross_reference: CHV:0000005784
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:3462
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0010566
database_cross_reference: LCH_NW:sh2008009753
database_cross_reference: MDR:10019105
database_cross_reference: MDR:10061193
database_cross_reference: MSH:D006222
database_cross_reference: NCI:C3075
database_cross_reference: NCI_CDISC:C3075
database_cross_reference: NCI_NCI-GLOSS:CDR0000044500
database_cross_reference: NDFRT:N0000001405
database_cross_reference: RCD:Xa1y1
database_cross_reference: SNM:M-75500
database_cross_reference: SNM:U000378
database_cross_reference: SNMI:M-75500
database_cross_reference: SNOMEDCT_US:400006008
database_cross_reference: SNOMEDCT_US:51398009

Melanoma
type: Class
subclass of: Neoplasm by histology
Definition: The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea).
MCID: MC00007993
PMOID: PMO:00014326
Subclass_of: Neoplasm by histology
Synonym: Cutaneous melanoma
Synonym: MALIGNANT MELANOMA
Synonym: MELANOMA
Synonym: MELANOMA MALIGNANT
Synonym: MELANOMA, MALIGNANT
Synonym: MM - Malignant melanoma
Synonym: Malignant Melanoma
Synonym: Malignant Melanomas
Synonym: Malignant melanoma
Synonym: Malignant melanoma (disorder)
Tree Number: T3.25.2.5
database_cross_reference: AOD:0000004558
database_cross_reference: BI:BI00601
database_cross_reference: CHV:0000007894
database_cross_reference: COSTAR:467
database_cross_reference: COSTAR:475
database_cross_reference: CSP:2020-2434
database_cross_reference: CST:MELANOMA SKIN
database_cross_reference: DO:DOID:1909
database_cross_reference: DO:DOID:8923
database_cross_reference: DXP:U001151
database_cross_reference: HPO:HP:0002861
database_cross_reference: HPO:HP:0012056
database_cross_reference: ICD10AM:M8720/3
database_cross_reference: ICPC2P:S77003
database_cross_reference: LCH:U002889
database_cross_reference: LCH_NW:sh85083381
database_cross_reference: LNC:LA14279-6
database_cross_reference: MDR:10025650
database_cross_reference: MDR:10027150
database_cross_reference: MDR:10053571
database_cross_reference: MEDCIN:352914
database_cross_reference: MEDLINEPLUS:321
database_cross_reference: MSH:D008545
database_cross_reference: MTH:475
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3224
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3224
database_cross_reference: NCI_CTEP-SDC:10053571
database_cross_reference: NCI_NCI-GLOSS:CDR0000045135
database_cross_reference: NCI_NICHD:C3224
database_cross_reference: NDFRT:N0000001969
database_cross_reference: OMIM:MTHU000127
database_cross_reference: OMIM:MTHU001388
database_cross_reference: PDQ:CDR0000038833
database_cross_reference: RCD:XE1wX
database_cross_reference: RCD:Xa99S
database_cross_reference: RCDSY:XE1wX
database_cross_reference: SNM:D-2946
database_cross_reference: SNM:M-8720/3
database_cross_reference: SNMI:M-87203
database_cross_reference: SNOMEDCT_US:154501005
database_cross_reference: SNOMEDCT_US:189749008
database_cross_reference: SNOMEDCT_US:2092003
database_cross_reference: SNOMEDCT_US:269503007
database_cross_reference: SNOMEDCT_US:269577007
database_cross_reference: SNOMEDCT_US:372244006
database_cross_reference: SNOMEDCT_VET:309331000009104

Nervous tissue neoplasm
type: Class
subclass of: Neoplasm by histology
Definition: A neoplasm derived from nervous tissue (not necessarity a neoplasm located in the nervous system).
MCID: MC00008743
PMOID: PMO:00014330
Subclass_of: Neoplasm by histology
Synonym: NEOPL NERVE TISSUE
Synonym: NEOPL NERVOUS TISSUE
Synonym: NERVE TISSUE NEOPL
Synonym: NERVOUS TISSUE NEOPL
Synonym: Neoplasm, Nerve Tissue
Synonym: Neoplasm, Nervous Tissue
Synonym: Neoplasms, Nerve Tissue
Synonym: Neoplasms, Nerve Tissue [Disease/Finding]
Synonym: Neoplasms, Nervous Tissue
Synonym: Nerve Tissue Neoplasm
Tree Number: T3.25.2.6
database_cross_reference: DO:DOID:3093
database_cross_reference: HPO:HP:0030060
database_cross_reference: MSH:D009380
database_cross_reference: NDFRT:N0000002139

Sarcoma
type: Class
subclass of: Neoplasm by histology
Definition: A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.
MCID: MC00423725
PMOID: PMO:00014345
Subclass_of: Neoplasm by histology
Synonym: Connective Tissue Sarcoma
Synonym: Malig tumor of soft tissue
Synonym: Malig tumour of soft tissue
Synonym: Malignant Neoplasm of Soft Tissue
Synonym: Malignant Neoplasm of the Soft Tissue
Synonym: Malignant Soft Tissue Neoplasm
Synonym: Malignant Soft Tissue Tumor
Synonym: Malignant Tumor of Soft Tissue
Synonym: Malignant Tumor of the Soft Tissue
Synonym: Malignant mesenchymal tumor
Tree Number: T3.25.2.7
database_cross_reference: AOD:0000004530
database_cross_reference: CCPSS:0020102
database_cross_reference: CCPSS:0046778
database_cross_reference: CHV:0000042636
database_cross_reference: CHV:0000056478
database_cross_reference: COSTAR:U000602
database_cross_reference: CSP:2000-8986
database_cross_reference: CST:SARCOMA
database_cross_reference: DO:DOID:0050652
database_cross_reference: HPO:HP:0030448
database_cross_reference: HPO:HP:0100242
database_cross_reference: ICD10AM:M8800/3
database_cross_reference: ICPC2P:A79013
database_cross_reference: ICPC2P:L71011
database_cross_reference: LCH:U004213
database_cross_reference: LCH_NW:sh85117504
database_cross_reference: MDR:10026699
database_cross_reference: MDR:10039491
database_cross_reference: MDR:10039494
database_cross_reference: MDR:10061271
database_cross_reference: MDR:10073145
database_cross_reference: MDR:10075333
database_cross_reference: MEDCIN:231737
database_cross_reference: MEDCIN:231878
database_cross_reference: MEDCIN:271492
database_cross_reference: MEDLINEPLUS:495
database_cross_reference: MSH:D012509
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4867
database_cross_reference: NCI:C9118
database_cross_reference: NCI:C9306
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C9118
database_cross_reference: NCI_CTEP-SDC:10039494
database_cross_reference: NCI_NCI-GLOSS:CDR0000045562
database_cross_reference: NCI_NCI-GLOSS:CDR0000046584
database_cross_reference: NCI_NICHD:C9118
database_cross_reference: NCI_NICHD:C9306
database_cross_reference: NDFRT:N0000002671
database_cross_reference: OMIM:MTHU017412
database_cross_reference: OMIM:MTHU022273
database_cross_reference: PDQ:CDR0000039253
database_cross_reference: PSY:45270
database_cross_reference: RCD:BBF1.
database_cross_reference: RCD:XE1vg
database_cross_reference: RCD:Xa97s
database_cross_reference: RCD:Xa99e
database_cross_reference: RCDAE:Xa97s
database_cross_reference: RCDAE:Xa99e
database_cross_reference: RCDSY:BBF1.
database_cross_reference: SNM:M-8800/3
database_cross_reference: SNMI:M-88003
database_cross_reference: SNOMEDCT_US:189764008
database_cross_reference: SNOMEDCT_US:2424003
database_cross_reference: SNOMEDCT_US:269469005
database_cross_reference: SNOMEDCT_US:269634000
database_cross_reference: SNOMEDCT_US:363362006
database_cross_reference: SNOMEDCT_US:424413001
database_cross_reference: SNOMEDCT_US:424952003
database_cross_reference: SNOMEDCT_US:93765001

Biochemical Pathway
type: Class
subclass of: Thing
Definition: A series of biochemical reactions which occurs in a known sequence and can result in all or part of the initiation, progression or completion of a biological process or function.
MCID: MC00578239
PMOID: PMO:00014365
Subclass_of: owl:Thing
Synonym: Metabolic Network
Synonym: Metabolic Networks
Synonym: Network, Metabolic
Synonym: Networks, Metabolic
Tree Number: T4
database_cross_reference: MSH:D053858
database_cross_reference: NCI:C20633

Cell Differentiation or Development Pathway
type: Class
subclass of: Biochemical Pathway
Definition: A sequence of biological or biochemical events that are involved in embryological or cellular development.
MCID: MC00526114
PMOID: PMO:00014366
Subclass_of: Biochemical Pathway
Tree Number: T4.1
database_cross_reference: NCI:C39704

Agrin Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: The heparan sulfate proteoglycan agrin is well known as the key assembly factor of postsynaptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle. Signaling through muscle-specific proteins such as muscle specific kinase (MuSK) and or acetylcholine receptor (AchRs)/rapsyn, agrin can activate ubiquitously expressed Rac, Cdc42, and p21-activated kinase (PAK) that are involved in actin polymerization. Agrin also engages signaling pathways of several potent oncogenes (i.e., SFK, ErbB receptors, and cortactin). (This definition may be outdated - see the DesignNote.)
MCID: MC00523040
PMOID: PMO:00014367
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Agrin in Postsynaptic Differentiation
Tree Number: T4.1.1
database_cross_reference: NCI:C38975
database_cross_reference: NCI_BioC:C38975

ALK Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Heart formation is cued by a combination of positive and negative signals from surrounding tissues. Inhibitory signals that block heart formation in anterior paraxial mesoderm include Wnt family members expressed in dorsal neural tube and anti-BMPs expressed in the axial tissues (i.e., noggin in the notochord). Wnt signaling pathway, which is essential for setting up the entire body pattern during embryonic development, involves glycogen synthase kinase-3 (GSK3). In the absence of Wnt signaling, GSK3 is active and phosphorylates b-catenin resulting in its degradation by ubiquitin-mediated proteolysis. Activation of Wnt signaling inhibits GSK3, thereby preventing phosphorylation of b-catenin, which is then able to move to the nucleus. There it associates with members of the LEF-1/TCF family of transcription factors, which activate the transcription of genes like cyclin-D1, myc, and MMPs. The Wnt signaling pathway is blocked by a family of secreted proteins such as crescent and Dkk-1 sufficient for induction of heart formation in posterior mesoderm. BMP signaling can also be blocked by the BMP antagonists noggin and chordin, which are secreted from the notochord and cooperate with Wnts to prevent cardiogenesis. Receptors for BMPs, members of the transforming growth factor-beta (TGFb) superfamily, are persistently expressed during cardiac development, yet mice lacking type II or type IA BMP receptors die at gastrulation and cannot be used to assess potential later roles in creation of the heart. Activin receptor-like kinase 3 (ALK3) is specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. Cardiac muscle lacking ALK3 is specifically deficient in expressing TGFb2, an established paracrine mediator of cushion morphogenesis. In humans, congenital heart defects occur with a prevalence of at least 1% in newborns, and are even more common in death before term. Most frequent are de…
MCID: MC00525863
PMOID: PMO:00014368
Subclass_of: Cell Differentiation or Development Pathway
Synonym: ALK in cardiac myocytes
Tree Number: T4.1.2
database_cross_reference: NCI:C38982
database_cross_reference: NCI_BioC:C38982

Axon Guidance Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
MCID: MC00815366
PMOID: PMO:00014369
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Axon Guidance
Synonym: Axon Pathfinding
Synonym: Axon guidance
Synonym: Axonal Pathfinding
Synonym: Neural Guidance
Synonym: Neural Pathfinding
Synonym: Neurite Guidance
Synonym: Neuronal Guidance
Synonym: Neuronal Pathfinding
Synonym: Pathfinding, Axon
Tree Number: T4.1.3
database_cross_reference: CSP:2047-3461
database_cross_reference: GO:GO:0007411
database_cross_reference: MSH:D000071437
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91455
database_cross_reference: NCI_KEGG:C91455

Bone Remodeling Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Bone density and structure is maintained through a balance of bone resorption by osteoclasts and bone deposition by osteoblasts. The combination of simultaneous resorption and deposition creates continual remodeling of bone while excess osteoclast activity leads to an imbalance and a loss of bone density, causing osteoporosis. RANK (receptor activator of NF-kB ligand) is a receptor in the TNF receptor gene family that is involved in osteoclast differentiation. RANK-ligand, also called osteoprotegerin-ligand, binds to RANK, induces receptor dimerization, and activates downstream signaling. Osteoprotegerin is a decoy receptor for RANK-ligand that suppresses osteoclast activity and bone remodeling, helping to maintain balanced bone remodeling. RANK-ligand and osteoprotegerin are produced by osteoblasts and some factors regulate osteoclast activity indirectly through their action on the expression of these factors by osteoblasts. Binding of RANK-ligand to RANK activates signaling through TRAF-6. TRAF-6 induces several downstream signaling events, including activation of NF-kB, c-Fos and the kinase JNK1. Jnk-1 activation contributes to fos activation by RANK-ligand and may be involved in the modulation of RANK-ligand by other factors such as estrogen. Mice lacking the c-Fos gene have overly dense bone and decreased bone resorption due to reduced osteoclast differentiation, indicating that c-Fos is an important mediator of osteoclast differentiation. One of the results of c-Fos induction is transcriptional activation of interferon-beta. Interferon-beta binds to its receptor on neighboring osteoclast precursor cells to block RANK-ligand signaling and down-regulate c-Fos expression, inhibiting further osteoclast differentiation. Mice lacking interferon-beta or the interferon-beta receptor lose bone due to uncontrolled osteoclast activity, demonstrating the importance of this mechanism in vivo. Interferon-beta signaling could be used as a mechanism to prevent osteoporosis an…
MCID: MC00529056
PMOID: PMO:00014370
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Bone Remodelling
Synonym: Bone Remodelling Pathway
Tree Number: T4.1.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39212
database_cross_reference: NCI_BioC:C39212

Calcineurin Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: The differentiation of keratinocytes constantly replenishes the upper layers of human skin we lose each day. One factor that contributes to terminal keratinocyte differentiation is increased levels of intracellular calcium. Adding calcium to the medium of cultured keratinocytes elevates intracellular calcium and triggers differentiation. Intracellular calcium levels are also increased in response to phospholipase C activation, producing IP3 and releasing calcium from stores in the ER. Intracellular calcium alters multiple signaling pathways, one of which is binding to calmodulin to activate the serine-threonine protein phosphatase calcineurin. Calcineurin dephosphorylates and activates the transcription factor NFAT and both calcineurin and NFAT are expressed in differentiating keratinocytes. Activated NFAT can regulate transcription through binding its own cognate DNA binding site. One marker of keratinocyte differentiation, the p21 gene, is activated by NFAT by a different mechanism, with NFAT activating the p21 promoter by acting as a coactivator for the transcription factors Sp1 and Sp3.Another protein activated by calcium that may be involved in keratinocyte differentiation is protein kinase C (PKC). One substrate of activated PKC is MARCKS (myristoylated alanine-rich kinase C substrate). Phosphorylation of MARCKS by PKC in intact keratinocytes is not induced during calcium-induced differentiation, but does increase when tested in vitro. PKC activity is increased by calcium during keratinocyte differentiation but PKC MARCKS phosphorylation is blocked by the formation of a complex between calmodulin and MARCKS. The immunosuppressants cyclosporin-A (CsA) and FK506 inhibit T cell activation through indirect inhibition of NFAT activation and have several side effects including changes in the skin, suggesting that calcineurin activity may play a role in normal skin physiology. CsA is used to treat psoriasis, a disease involving abnormal proliferation of skin cells. T…
MCID: MC00526043
PMOID: PMO:00014371
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Effects of calcineurin in Keratinocyte Differentiation
Tree Number: T4.1.5
database_cross_reference: NCI:C39010
database_cross_reference: NCI_BioC:C39010

Dorso-Ventral Axis Formation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
MCID: MC01394238
PMOID: PMO:00014372
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Dorso-ventral axis formation
Tree Number: T4.1.6
database_cross_reference: NCI:C91432
database_cross_reference: NCI_KEGG:C91432

Erythrocyte Differentiation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth factors. CFU-GEMM cells are a key intermediate in the differentiation of granulocytes, erythrocytes, monocytes and megakaryocytes. Erythropoietin (EPO) is a cytokine produced in the kidneys that, along with other cytokines, induces red blood cell (erythrocyte) differentiation in the bone marrow from CFU-GEMM cells. As the erythrocyte lineage progresses, cells lose their nuclei, and move out of the bone marrow into circulation. The ability of EPO to selectively induce red blood cell differentiation has allowed extensive therapeutic use of the recombinant form of this cytokine to treat anemias. (This definition may be outdated - see the DesignNote.)
MCID: MC00526386
PMOID: PMO:00014373
Subclass_of: Cell Differentiation or Development Pathway
Tree Number: T4.1.7
database_cross_reference: NCI:C39073
database_cross_reference: NCI_BioC:C39073

Function of SLRP in Bone Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: SLRPs (Small leucine-rich proteoglycans) are extracellular molecules that bind to TGF-betas, collagens and other matrix molecules. In vitro, SLRPs were shown to regulate collagen fibrillogenesis, a process essential in development, tissue repair, and metastasis. The resilience and strength of bone is due to the orderly mineralization of a specialized extracellular matrix (ECM) composed of type I collagen (90%) and a host of non-collagenous proteins that are, in general, also found in other tissues. Biglycan (an SLRP encoded by the gene Bgn) is an ECM proteoglycan that is enriched in bone and other non-skeletal connective tissues. In vitro studies indicate that Bgn may function in connective tissue metabolism by binding to collagen fibrils and TGF-beta, and may promote neuronal survival. The effects of an individual SLRP deficiency are tissue specific and a variety of morphological phenotypes are the result of variations in level of expression of individual SLRPs in different tissues and synergisms between different SLRPs (and likely other macromolecules) in determining matrix structures. For example collagen structural phenotypes demonstrate a cooperative, sequential, timely orchestrated action of the SLRPs that altogether shape the architecture and mechanical properties of the collagen matrix. Disruption of the bgn gene results in reduced skeletal growth and bone mass leading to generalized osteopenia, particularly in older animals. In addition, other SLRP-deficient mice develop a wide array of diseases (osteoporosis, osteoarthritis, muscular dystrophy, Ehlers-Danlos syndrome, and corneal diseases), most of them resulting primarily from an abnormal collagen fibrillogenesis. (This definition may be outdated - see the DesignNote.)
MCID: MC01394139
PMOID: PMO:00014374
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Function of SLRP in Bone: An Integrated View
Synonym: Small Leucine-Rich Proteoglycans in Bone Pathway
Tree Number: T4.1.8
database_cross_reference: NCI:C91301
database_cross_reference: NCI_BioC:C91301

Hematopoiesis Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: The process of hematopoiesis is regulated by various cytokines. The combination of cytokines stimulates the proliferation and/or differentiation of the various hematopoietic cell types. Bone marrow stromal cells are the major source of hematopoietic cytokines in the non-infectious state. In the presence of infection, cytokines produced by activated macrophages and TH cells induce hematopoietic activity. The induction by cytokines results in rapid expansion of the population of white blood cells to fight infection. (This definition may be outdated - see the DesignNote.)
MCID: MC00523890
PMOID: PMO:00014375
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Regulation of hematopoiesis by cytokines
Tree Number: T4.1.9
database_cross_reference: NCI:C39240
database_cross_reference: NCI_BioC:C39240

HOP Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Homeodomain transcription factors comprise a large family of DNA binding factors that regulate transcription and development. Many homeodomain genes arranged in genomic clusters determine anterior-posterior patterning, while others determine the fate of cells in specific tissues. The proliferation of cardiac myocytes and their differentiation early in development are dependent on the coordinate expression and action of serum response factor (SRF), GATA4 and the homeodomain factor Nkx2-5. All three of these factors are expressed in developing cardiomyocytes and induce expression of cardiac genes. Disruption of the Nkx2-5 gene in mice leads to embryonic lethality and defective cardiac development. SRF also plays a dual role in cardiac development, influencing both cardiomyocyte proliferation and differentiation depending on the stage and other signals that are present. In addition, the Hop (Homeodomain Only Protein) gene encodes a factor expressed early in cardiac development that is involved in cardiac differentiation. Hop inactivation in vertebrates leads to severe defects in cardiac development, acting downstream of Nkx2-5. Cardiac cells from mice lacking the Hop gene fail to exit the cell cycle in the normal manner, continuing to proliferate past the normal developmental stage. Many of the genes disregulated in the absence of Hop are involved in the cell cycle and are also targets of SRF. Although Hop is a homeodomain protein, it lacks a DNA-binding domain indicating that it must not regulate gene expression directly. Hop appears to regulate the expression of cardiac genes by binding to SRF and blocking DNA binding of SRF. The sequestration of SRF by Hop blocks the activation of cardiac genes, preventing normal cardiac development. The influence of Hop on the opposing processes of cardiomyocyte differentiation and proliferation reflect the interaction of Hop with SRF and the duel role SRF plays. In early cardiac development, Hop opposes differentiation induction b…
MCID: MC00523869
PMOID: PMO:00014376
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Homeodomain-Only Protein Pathway
Synonym: Hop Pathway in Cardiac Development
Tree Number: T4.1.10
database_cross_reference: NCI:C39107
database_cross_reference: NCI_BioC:C39107

Keratinocyte Differentiation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located in the basal layer. As cells leave the basal layer they undergo significant differentiation and biochemical and morphological remodeling. The final differentiation results in the formation of corneocytes. In vitro keratinocytes mimic this process. Several genes mark keratinocyte specific differentiation. Among the most frequently tracked markers are transglutaminase, cystatin and involucrin. Keratinocyte differentiation studies have identified and provided significant detail regarding the involvement of three of the 4 major MAP kinase pathways from several diverse stimuli such as EGF, FAS, TNF and calcium influx. The keratinocyte differentiation cascades also provide for detailed study of the functions of individual PKC isoforms and it is interesting to note the contrasting functions of the PKC isoforms in this process. In recent studies it has been determined that the cPKC (conventional/classical Protein Kinase C) isoforms, which are calcium-, phospholipid-, and diacylglycerol-dependent are inhibitory where as the nPKC (novel Protein Kinase C) isoforms which are calcium independent are stimulatory for keratinocyte differentiation markers. (This definition may be outdated - see the DesignNote.)
MCID: MC01393659
PMOID: PMO:00014377
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Keratinocyte Differentiation
Tree Number: T4.1.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39135
database_cross_reference: NCI_BioC:C39135

Lissencephaly-1 Gene in Neuronal Migration and Development
type: Class
subclass of: Cell Differentiation or Development Pathway
PMOID: PMO:00014378
Subclass_of: Cell Differentiation or Development Pathway
Tree Number: T4.1.12

Macrophage Differentiation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Terminal differentiation of cells is often accompanied by repression of cellular proliferation, suggesting that there is a mechanism by which these cellular functions are coordinated. Macrophage differentiation is one model system in which this occurs; as macrophages differentiate, they also stop proliferating. Transcriptional regulation plays a key role in cell cycle progression as well as many differentiation processes. Ras stimulates cell cycle progression in part through Ets transcription factors that bind to cell cycle regulatory genes to activate their expression. Ets transcription factors also help to induce early macrophage differentiation. The activation of Ras signaling by M-CSF activates transcription of genes involved in differentiation through the coordinate expression of both Ets factors and AP-1. Other genes involved in cell cycle regulation coordinate action of E2F-1 and Ets transcription factors. Mets is a factor related in sequence to Ets2 that is upregulated during macrophage differentiation. Increased expression of the Mets protein during macrophage differentiation allows the creation of heterodimers with DP103 to act as transcriptional repressors of cell cycle progression genes, recruiting corepressor to promoters they interact with. DP103 is a gene previously identified as an RNA helicase involved in RNA processing that interacts with EBNA factors from Epstein Barr Virus. The transcriptional repression involving Mets with DP103 is selective, and does not involve all Ets regulated genes. While cell cycle genes are repressed by Mets, other genes activated by Ets factors such as those involved in differentiation are not repressed by Mets. The transcriptional repression by Mets also involved members of the Rb family of tumor suppressors, such as p107 and p130. This requirement for additional factors involved in regulating proliferation may allow for another level of control on cell proliferation and coordination with differentiation. (This definiti…
MCID: MC00527050
PMOID: PMO:00014379
Subclass_of: Cell Differentiation or Development Pathway
Synonym: METS affect on Macrophage Differentiation
Tree Number: T4.1.13
database_cross_reference: NCI:C39075
database_cross_reference: NCI_BioC:C39075

Melanocyte Development Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Studies with homozygous knockout mice have suggested that stem cell factor (SCF or KITLG), c-Kit, microphthalmia (Mitf), and B-cell CLL/lymphoma 2 (Bcl2) genes regulate melanocytic development. The SCF activation of Kit receptor leads to Mitf phosphorylation through the MAP kinase pathway. The activated Mitf recruits p300 and up-regulates Bcl2 transcription, which plays an important role in modulating the development and survival of the melanocyte lineage. (This definition may be outdated - see the DesignNote.)
MCID: MC00524246
PMOID: PMO:00014380
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Melanocyte Development and Pigmentation Pathway
Tree Number: T4.1.14
database_cross_reference: NCI:C39150
database_cross_reference: NCI_BioC:C39150

Nephrin Signaling Pathway in the Kidney Podocyte
type: Class
subclass of: Cell Differentiation or Development Pathway
MCID: MC01393829
PMOID: PMO:00014381
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Nephrin/Neph1 signaling in the kidney podocyte
Tree Number: T4.1.15
database_cross_reference: NCI:C91637
database_cross_reference: NCI_PID:C91637

Neuronal Survival Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF and neurotrophin-3 that stimulate the survival of the associated neuron. Local signaling by activated Trk receptors at the synaptic terminus mediates some presynaptic neuronal responses to neurotrophins. Map kinase pathways activated by Trk receptor activate Erk1 and Erk2 at the terminus stimulating axonal growth, and PI3K activates AKT in the terminus as well. Activation of these kinases does not propagate a signal to the cell body though and does not induce a transcriptional response. This local signaling at the terminus or local signaling at the cell body appears distinct from the signaling pathway that transduces the survival signal from the target tissue. Retrograde axonal transport plays an essential role in neuronal survival induced by neurotrophins released at the target tissue. Failure of retrograde neurotrophin signaling may play a role in neurodegenerative conditions. The neuronal survival signal is initiated by binding of neurotrophins to Trk receptors in the presynaptic membrane, and then travels back along the axon to the neuronal cell body. To transmit the signal back along the axon, activated Trk receptors are internalized through receptor-mediated endocytosis and receptor containing vesicles then rapidly travel back to the cell body along axonal microtubules. Several reports indicate that neurotrophins remain receptor-bound during the retrograde axonal transport to the cell body, but recently it was reported that retrograde transport of NGF was not required to induce neuronal survival. Once in the cell body, Trk receptors activate multiple pathways. A key pathway activated by Trk after retrograde transport involves Erk5, also called BMK1. Trk activates Mek5, which activates Erk5, inducing phosphorylation of the CREB and Mef2 transcription factors. Erk5 does not directly phosphorylate CREB, but transloca…
MCID: MC00527138
PMOID: PMO:00014382
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Role of Erk5 in Neuronal Survival
Tree Number: T4.1.16
database_cross_reference: NCI:C39071
database_cross_reference: NCI_BioC:C39071

Neurotrophin Signaling Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and negative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.
MCID: MC00815365
PMOID: PMO:00014383
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Neurotrophin signaling pathway
Synonym: neurotrophin receptor signaling pathway
Synonym: neurotrophin signaling pathway
Tree Number: T4.1.17
database_cross_reference: GO:GO:0038179
database_cross_reference: NCI:C91443
database_cross_reference: NCI_KEGG:C91443

Oocyte Maturation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Progesterone (Pg) binds to both intracellular iPR and plasma membrane-bound mPR. After binding to Pg, iPR is recruited to the membrane associated protein tyrosine kinase p60c-src, which induces activation of the MAPK signaling pathway. This results in activation of p90Rsk and the subsequent phosphorylation and inactivation of Myt1, which favors formation of the activated cell cycle complex cyclin B-Cdc2. Activation of cyclin B-Cdc2 causes breakdown of the germinal vesicle and the initiation of oocyte maturation. In contrast, binding of Pg to mPR leads to inhibition of adenylyl cyclase (AC) through activation of Gai or inhibition of Gas. This leads to a decrease in the cAMP-dependent kinase PKA, which relieves inhibition of Cdc25C and also indirectly promotes the activation of MAPK signaling. PKA also regulates the initiation of oocyte maturation through other effects that are independent of PKA activity. (This definition may be outdated - see the DesignNote.)
MCID: MC00527231
PMOID: PMO:00014384
Subclass_of: Cell Differentiation or Development Pathway
Synonym: How Progesterone Initiates the Oocyte Maturation
Tree Number: T4.1.18
database_cross_reference: NCI:C39156
database_cross_reference: NCI_BioC:C39156

Progesterone-Mediated Oocyte Maturation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
MCID: MC01393670
PMOID: PMO:00014385
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Progesterone-mediated oocyte maturation
Tree Number: T4.1.19
database_cross_reference: NCI:C91492
database_cross_reference: NCI_KEGG:C91492

Segmentation Clock Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation, a specialized mesodermal structure called the somite gives rise to skeletal muscles, vertebrae, and some dermis. Formation of the somites is a rhythmic process that involves an oscillator, the segmentation clock, driven by Wnt and Notch signaling. The clock ticks in somite precursors and halts when they reach a specific maturation stage defined as the wavefront, established by FGF and Wnt signaling. Lunatic fringe was shown to act downstream of Notch and to bind and negatively regulate its own promoter. Another cyclic gene is hes1. It acts also downstream of Notch and codes for an unstable protein able to negatively regulate its own promoter too. (This definition may be outdated - see the DesignNote.)
MCID: MC00527550
PMOID: PMO:00014386
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Segmentation Clock
Tree Number: T4.1.20
database_cross_reference: NCI:C39104
database_cross_reference: NCI_BioC:C39104

Signal Dependent Regulation of Myogenesis Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds to promoters to activate genes involved in muscle cell differentiation. One of the factors that regulates the role of MyoD/MEF2 in myogenesis is the protein MEF2-interacting transcription repressor (MITR), a transcriptional repressor. When MITR is bound to MEF2, myogenesis genes are repressed rather than being activated. The transcriptional repression by MITR occurs in part at least through interaction with the CtBP (carboxy-terminal binding protein) corepressor. The inhibitory activity of MITR is itself regulated by the calmodulin dependent protein kinase CAMK. When CAMK is activated by factors such as IGF-1, it phosphorylates two specific residues in MITR, ser218 and ser448. Phosphorylated MITR does not bind to MEF2, but does bind to the protein 14-3-3, helping to block the repression of myogenesis. CAMK also plays a role in myogenesis through phosphorylation of histone deacetylase (HDAC), in which HDAC alters chromatin to repress myogenesis. Like MITR, phosphorylation of HDAC removes the repression, allowing myogenesis to continue. MITR shares sequence homology with HDAC, but itself lacks the enzyme motif. (This definition may be outdated - see the DesignNote.)
MCID: MC00527587
PMOID: PMO:00014387
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Signal Dependent Regulation of Myogenesis by Corepressor MITR
Tree Number: T4.1.21
database_cross_reference: NCI:C39155
database_cross_reference: NCI_BioC:C39155

Skeletal Myogenesis Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to MyoD and other basic helix-loop-helix factors to activate transcription of genes involved in muscle cell differentiation. Transcriptional activation by MEF2 is blocked by interaction with HDAC5 and other histone deacetylases. In undifferentiated myoblasts, HDAC5 is present in the nucleus where it binds to MEF2 to block activation of muscle genes. When activated by IGF-1 signaling, CaM kinase phosphorylates HDAC proteins, causing them to be exported from the nucleus, releasing the block on MEF2 transcriptional activation and allowing differentiation to proceed. Transcription cofactors also interact with MEF2 to contribute to gene regulation and myogenesis. The transcriptional regulator NFAT, for example, acts as a cofactor for MEF2 when calcium and calcineurin signaling activate it. There are four members of the Mef2 gene family, Mef2a-2d. Mef2a is expressed in brain, heart and skeletal muscle. Mef2c is involved in myogenesis in cardiac and skeletal muscle. Mef2d is widely expressed, and may be involved in the regulation of T cell function as well as muscle. Several factors regulate Mef2 transcription factors, including Map kinases and histone deacetylase (HDAC) enzymes. Mef2 is phosphorylated by p38 map kinase, and phosphorylation of Mef2c by p38 contributes to skeletal muscle differentiation. BMK-1 (also called Erk5) is another member of the Map kinase family that regulates the activity of Mef2 family members and is unique in that it appears itself to possess a transcriptional activation domain and act as a transcriptional coactivator. Mekk3 disruption prevented normal cardiovascular development in mice and appears to signal through p38 and Mef2c in normal cardiovascular development. (This definition may be outdated - see the DesignNote.)
MCID: MC00527609
PMOID: PMO:00014388
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)
Tree Number: T4.1.22
database_cross_reference: NCI:C39102
database_cross_reference: NCI_BioC:C39102

Small Leucine-Rich Proteoglycan (SLRP) Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: The small leucine-rich proteoglycans (SLRPs) are a family of proteins that are present in extracellular matrix and that share in common multiple repeats of a leucine-rich structural motif, flanked by cysteine residues. These proteins appear to interact in many cases with collagen, modifying the deposition and arrangement of collagen fibers in the extracellular matrix, and also with cells and with soluble growth factors. The interaction of SLRPs with cells and with growth factors like TGF-beta may affect the proliferation of cells in addition to modifying the extracellular environment. Post-translational modification of SLRPs with carbohydrates and sulfate-containing groups appears to modify the function of SLRPs. Changes in SLRP expression and modification in cornea, atherosclerotic plaque, joints, bone, tendons, and kidney may be associated with disease progression in those tissues. Decorin is one SLRP expressed throughout the body that stabilizes collagen fibrils and that also antagonizes the action of the cytokine TGF-beta, blocking cell cycle progression, and potentially playing a role in cancer and wound healing. The SLRP biglycan is expressed in bone and other connective tissues and genetic disruption of biglycan in mice causes low bone mass similar to osteoporosis. (This definition may be outdated - see the DesignNote.)
MCID: MC01394142
PMOID: PMO:00014389
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Small Leucine-Rich Proteoglycan (SLRP) Molecules
Tree Number: T4.1.23
database_cross_reference: NCI:C91302
database_cross_reference: NCI_BioC:C91302

Synaptic Junction Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: The postsynaptic density (PSD) is a submembranous structure at the postsynaptic membrane mainly at the excitatory synapses. The neurotransmitter receptors are assembled and fixed at the PSD, and several molecules implicated in the synaptic plasticity are also enriched. PSD-95/synapse-associated protein (SAP) 90 is involved in the molecular organization of these components of the PSD and essential for learning and memory. The common feature of these postsynaptic proteins is that they have PSD-95/Dlg/ZO-1 (PDZ) modular domains for protein-protein interaction. PDZ domains of these proteins directly recognize the C termini of their target proteins and are believed to play a central role in targeting and clustering of receptors to proper synaptic membranes. (This definition may be outdated - see the DesignNote.)
MCID: MC00525297
PMOID: PMO:00014390
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Synaptic Proteins at the Synaptic Junction
Tree Number: T4.1.24
database_cross_reference: NCI:C39185
database_cross_reference: NCI_BioC:C39185

Th1/Th2 Differentiation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
Definition: Helper T cells are found in two distinct cell types, Th1 and Th2, distinguished by the cytokines they produce and respond to and the immune responses they are involved in. Th1 cells produce pro-inflammatory cytokines like IFN-g, TNF-b and IL-2, while Th2 cells produce the cytokines IL-4, IL-5, IL-6 and IL-13. The cytokines produced by Th1 cells stimulate the phagocytosis and destruction of microbial pathogens while Th2 cytokines like IL-4 generally stimulate the production of antibodies directed toward large extracellular parasites. IL-5 stimulates eosinophil responses, also part of the immune response toward large extracellular parasites. Th1 and Th2 are produced by differentiation from a non-antigen exposed precursor cell type, Thp. Exposure of Thp cells to antigen by antigen-presenting cells may result in their differentiation to Th0 cells, not yet committed to become either Th1 or Th2 cells, although the existence of Th0 cells is controversial. Cells committed as either Th1 or Th2 cells are called polarized, whether they are effector cells actively secreting cytokines or are memory cells. The stimulation of Thp cells by exposure to antigen-presenting cells induces the proliferation of undifferentiated cells, and their expression of IL-2 and IL-2 receptor. The differentiation of Th1 cells and Th2 cells depends on the cytokines they are exposed to. IL-12 causes Th1 differentiation and blocks Th2 cell production, while IL-4 causes Th2 differentiation and antagonizes Th1 development. IL-18 also induces Th1 differentiation. Polarized Th1 and Th2 cells also express distinct sets of chemokine receptors that further modify their homing and other cellular responses. Improved understanding of Th1 and Th2 differentiation will improve our overall understanding of the immune system, its response to infection, and aberrant responses that lead to disease. (This definition may be outdated - see the DesignNote.)
MCID: MC00525476
PMOID: PMO:00014391
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Th1/Th2 Differentiation
Tree Number: T4.1.25
database_cross_reference: NCI:C39252
database_cross_reference: NCI_BioC:C39252

Cell Motility Pathway
type: Class
subclass of: Biochemical Pathway
Definition: An elaboration of the known steps and interactions required to allow cell movement.
MCID: MC01393960
PMOID: PMO:00014392
Subclass_of: Biochemical Pathway
Tree Number: T4.2
database_cross_reference: NCI:C39703

Actin Branching Pathway
type: Class
subclass of: Cell Motility Pathway
Definition: Mammalian cell motility requires actin polymerization in the direction of movement to change membrane shape and extend cytoplasm into lamellipodia. The polymerization of actin to drive cell movement also involves branching of actin filaments into a network oriented with the growing ends of the fibers near the cell membrane. Manipulation of this process helps bacteria like Salmonella gain entry into cells they infect. Two of the proteins involved in the formation of Y branches and in cell motility are Arp2 and Arp3, both members of a large multiprotein complex containing several other polypeptides as well. The Arp2/3 complex is localized at the Y branch junction and induces actin polymerization. Activity of this complex is regulated by multiple different cell surface receptor signaling systems, activating WASP, and Arp2/3 in turn to cause changes in cell shape and cell motility. Wasp and its cousin Wave-1 interact with the Arp2/3 complex through the p21 component of the complex. The crystal structure of the Arp2/3 complex has revealed further insights into the nature of how the complex works. Activation by Wave-1, another member of the WASP family, also induces actin alterations in response to Rac1 signals upstream. Wave-1 is held in an inactive complex in the cytosol that is activated to allow Wave-1 to associate with Arp2/3. While WASP is activated by interaction with Cdc42, Wave-1, is activated by interaction with Rac1 and Nck. Wave-1 activation by Rac1 and Nck releases Wave-1 with Hspc300 to activate actin Y branching and polymerization by Arp2/3. Different members of this gene family may produce different actin cytoskeletal architectures. The immunological defects associated with mutation of the WASP gene, the Wiskott-Aldrich syndrome for which WASP was named, indicates the importance of this system for normal cellular function. (This definition may be outdated - see the DesignNote.)
MCID: MC00525884
PMOID: PMO:00014393
Subclass_of: Cell Motility Pathway
Synonym: Y branching of actin filaments
Tree Number: T4.2.1
database_cross_reference: NCI:C38973
database_cross_reference: NCI_BioC:C38973

Actin Cytoskeleton Regulation Pathway
type: Class
subclass of: Cell Motility Pathway
MCID: MC01394214
PMOID: PMO:00014394
Subclass_of: Cell Motility Pathway
Synonym: Regulation of actin cytoskeleton
Tree Number: T4.2.2
database_cross_reference: NCI:C91435
database_cross_reference: NCI_KEGG:C91435

Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
type: Class
subclass of: Cell Motility Pathway
MCID: MC01393748
PMOID: PMO:00014395
Subclass_of: Cell Motility Pathway
Synonym: a4b1 and a4b7 Integrin signaling
Tree Number: T4.2.3
database_cross_reference: NCI:C91533
database_cross_reference: NCI_PID:C91533

Paxillin-Dependent Alpha4/Beta1 Integrin Signaling Pathway
type: Class
subclass of: Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
MCID: MC01393853
PMOID: PMO:00014396
Subclass_of: Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
Synonym: Paxillin-dependent events mediated by a4b1
Tree Number: T4.2.3.1
database_cross_reference: NCI:C91645
database_cross_reference: NCI_PID:C91645

Paxillin-Independent Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
type: Class
subclass of: Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
MCID: MC01393856
PMOID: PMO:00014397
Subclass_of: Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
Synonym: Paxillin-independent events mediated by a4b1 and a4b7
Tree Number: T4.2.3.2
database_cross_reference: NCI:C91646
database_cross_reference: NCI_PID:C91646

Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway
type: Class
subclass of: Cell Motility Pathway
MCID: MC01393750
PMOID: PMO:00014398
Subclass_of: Cell Motility Pathway
Synonym: a6b1 and a6b4 Integrin signaling
Tree Number: T4.2.4
database_cross_reference: NCI:C91534
database_cross_reference: NCI_PID:C91534

AlphaM/Beta2 Integrin Signaling Pathway
type: Class
subclass of: Cell Motility Pathway
MCID: MC01393798
PMOID: PMO:00014399
Subclass_of: Cell Motility Pathway
Synonym: amb2 Integrin signaling
Tree Number: T4.2.5
database_cross_reference: NCI:C91537
database_cross_reference: NCI_PID:C91537

Calpain-1 Cell Spread Pathway
type: Class
subclass of: Cell Motility Pathway
Definition: The mammalian calpain gene family currently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. Spreading cells display newly transiently formed integrin adhesion clusters containing Calpain1 (mu-Calpain), cleaved Talin, B3-Integrin, and SPTAN1 (Spectrin). Recruitment of Rac to these clusters leads to the activation of Rac and the formation of Rac-induced focal clusters. The Calpain1 in the integrin clusters initially inactivates RhoA allowing for the formation of lamellipodia. The subsequent activation of newly synthesized RhoA transforms these clusters into Focal Adhesion Complexes and the formation of contractile actin-myosin stress fibers. These mature adhesions do not contain calpain. (This definition may be outdated - see the DesignNote.)
MCID: MC00525857
PMOID: PMO:00014400
Subclass_of: Cell Motility Pathway
Synonym: mu-Calpain Cell Spread Pathway
Synonym: uCalpain and friends in Cell spread
Tree Number: T4.2.6
database_cross_reference: NCI:C39262
database_cross_reference: NCI_BioC:C39262

Calpain-2 Cell Motility Pathway
type: Class
subclass of: Cell Motility Pathway
Definition: The mammalian calpain gene family currently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. One of the most carefully studied functions of the calpains is the regulation of integrin-mediated cell migration. Calpains digest the links between the actin cytoskeleton and several focal adhesion complex proteins; talin, paxillin and focal adhesion kinase. The release from the focal adhesion complex facilitates migration. Calpastatin is an inhibitor expressed in most cells. Calpastatin binds the four inhibitory domains of calpain. Release from calpastatin does not activate calpain. Activation requires additional signaling, coactivators, and an appropriate calcium concentration. During cell migration calpain1 (mu-calpain) acts at the leading edge as a response to integrin signals or calcium fluctuations due to the stretch activated calcium channels. Calpain1 cleaves the target proteins, talin, ezrin, paxillin, and the cytoplasmic tail of the integrins B1(a) and B3(b) to release the adhesion and form new adhesions. Calpain2 (M-calpain) is believed to be membrane bound and functions at the trailing edge of the migrating cell to cleave the integrins in response to growth factor receptor signals. PKA functions to down regulate or inhibit calpain2. In Alzheimer's disease, amyloid peptides interfere with calpain activity causing a mislocalization of cdk5. Deregulated cdk5 hyperphosphorylates tau promoting cell death in neurons. Mutations in the muscle specific calpain p94 lead to Limb Girdle muscular dystrophy 2A (LGMD2A). Over activity of calpains due to elevated calcium leads to tissue damage in the heart and brain. (This definition may be outdated - see the DesignNote.)
MCID: MC00526050
PMOID: PMO:00014401
Subclass_of: Cell Motility Pathway
Synonym: M-Calpain Cell Motility Pathway
Synonym: mCalpain and friends in Cell motility
Tree Number: T4.2.7
database_cross_reference: NCI:C39147
database_cross_reference: NCI_BioC:C39147

Cell Migration Pathway
type: Class
subclass of: Cell Motility Pathway
Definition: Migration of cells is involved in essential functions such as development, invasiveness of cancer cells, leukocyte movement toward chemotactic signals, and fibroblast response to injury. Cells can migrate in a specific direction in response to extracellular signals through pathways that trigger changes in the cytoskeleton, particularly actin filaments, increasing lamellipodia and filopodia formation and decreasing focal adhesions. Factors like PDGF activate PI3 kinase and multiple pathways downstream to stimulate cell migration. One pathway regulating migration through the p85 regulatory subunit of PI3 kinase does not require PI3-kinase activity. In this pathway, p85 of PI3-kinase activates cdc42, which activates N-Wasp (Wiskott-Aldrich Syndrome Protein) to regulate ARP-2/3. ARP-2/3 is a complex of proteins localized at the leading edge of moving cells that nucleates the formation of new actin fibers and interacts with Wasp to stimulate migration. The cdc42 pathway also regulates p21-activate kinase 1 (PAK1). Another pathway by which PI3 kinase regulates migration is through the small GTPase Rac. PAK1 is a downstream target of Rac as well as cdc42. Downstream of Rac and PAK1, Myosin light chain kinase (MLCK) phosphorylates myosin light chain to increase cell migration. The regulation of the localization and activity of signaling factors creates coordinated pathways linking extracellular signals and cellular migration. (This definition may be outdated - see the DesignNote.)
MCID: MC00526118
PMOID: PMO:00014402
Subclass_of: Cell Motility Pathway
Synonym: Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration
Tree Number: T4.2.8
database_cross_reference: NCI:C39021
database_cross_reference: NCI_BioC:C39021

Extracellular Matrix Binding Pathway
type: Class
subclass of: Cell Motility Pathway
Definition: Activation of the MAPK kinase pathway has been identified as a mechanism that integrins use to regulate gene expression, leading to cell shape changes during cell spreading or migration. Epithelial cells respond to extracellular matrix (ECM) causing integrin-mediated FAK phosphorylation; this, in turn, phosphorylates the surrounding proteins (paxillin, Fyn/shc, and src) and leads to signal amplification. FAK also binds PI-3 kinase and acts upstream in the MAP kinase pathway. When MAP kinase or PI-3 kinase is inhibited, actin reorganization is blocked. Src phosphorylates p190RhoGAP, inactivating its GAP function and allowing RhoGTP to stay active longer, promoting further signal amplification. Activated RhoGTP binds to downstream kinases such as Rho-associated coiled coil-containing protein kinase (p160ROCK) and p140 diaphanous (p140Dia) to increase actin polymerization and contraction. Actin reorganization assists integrin clustering, allowing more ECM binding that increase FAK phosphorylation and other signal transduction events. (This definition may be outdated - see the DesignNote.)
MCID: MC00526418
PMOID: PMO:00014403
Subclass_of: Cell Motility Pathway
Synonym: Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
Tree Number: T4.2.9
database_cross_reference: NCI:C39054
database_cross_reference: NCI_BioC:C39054

Focal Adhesion Pathway
type: Class
subclass of: Cell Motility Pathway
Definition: Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signaling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signaling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signaling.
MCID: MC00524125
PMOID: PMO:00014404
Subclass_of: Cell Motility Pathway
Synonym: Focal Adhesion
Synonym: Focal adhesion pathway
Synonym: Integrin-mediated Cell Adhesion
Synonym: Integrin-mediated Cell Adhesion Pathway
Synonym: cell adhesion mediated by integrin
Synonym: cell adhesion mediated by integrin complex
Tree Number: T4.2.10
database_cross_reference: GO:GO:0033627
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38829
database_cross_reference: NCI_KEGG:C38829

Granulocyte Adhesion Pathway
type: Class
subclass of: Cell Motility Pathway
Definition: Cell adhesion is a fundamental feature of multicellular organisms including their defense mechanisms. In the later case in mammals, leukocytes play central role. They bind bacteria, parasites, viruses, tumor cells etc. Furthermore, their interactions with the endothelium are of special importance. During an inflammation or immune reaction, specialized leukocytes (eosinophilic granulocytes) adhere to and pass through the endothelium of the blood vessels and the underlying matrix. The reaction passes through the following steps: 1. Rolling (the flow of cells is slowed down by first making contacts to the endothelium via P-, E-, and L-selectins and their receptors); 2. Adhesion (After activation of leukocyte integrins, firm contacts are established between them and endothelium molecules of the Ig superfamily - LFA-1, Mac-1, VLA-4 etc.); 3. Flattening of the cells and diapedesis (Adhering leukocytes crawl to an intercellular junction of the endothelium and then transmigrate to or even through the intercellular matrix. This is mediated by homophilic interactions of PECAM and CD31. (This definition may be outdated - see the DesignNote.)
MCID: MC00523845
PMOID: PMO:00014405
Subclass_of: Cell Motility Pathway
Synonym: Adhesion and Diapedesis of Granulocytes
Tree Number: T4.2.11
database_cross_reference: NCI:C39097
database_cross_reference: NCI_BioC:C39097

LIS1 Pathway
type: Class
subclass of: Cell Motility Pathway
Definition: LIS1 can bind to MT bundles; however, phospho-LIS1 binding to MT bundles is mediated through the distal zinc finger motif of CLIP-170. When the distal zinc finger motif of CLIP-170 is mutated, the phospho-LIS1 isoform can no longer bind to MT bundles. This can also explain why p150/dynactin is not recruited to the MT bundles. CLIP-170 targets the dynein/dynactin complex to the MT, using phopho-LIS1 as an adapter; the motor complex, being in the proximity of the MT, associates with it. The initial static link to the MT provided by CLIP-170 is released by its hyperphosphorylation and the retrograde dynein/dynactin-dependent movement of the cargo (endocytic vesicle, kinetochore, etc.) takes place. Doublecortin (DCX) is placed close to the LIS1 pathway based on its interaction with LIS1 and its role in microtubule dynamics. (This definition may be outdated - see the DesignNote.)
MCID: MC00526768
PMOID: PMO:00014406
Subclass_of: Cell Motility Pathway
Synonym: Lissencephaly gene (LIS1) in neuronal migration and development
Synonym: Lissencephaly-1 Gene in Neuronal Migration and Development
Synonym: PAFAH1B1 Gene in Neuronal Migration and Development
Tree Number: T4.2.12
database_cross_reference: NCI:C39140
database_cross_reference: NCI:C91630
database_cross_reference: NCI_BioC:C39140
database_cross_reference: NCI_PID:C91630

Lymphocyte Adhesion Pathway
type: Class
subclass of: Cell Motility Pathway
Definition: Cell adhesion is a fundamental feature of multicellular organisms including their defense mechanisms. In the later case in mammals, leukocytes play a central role. They bind bacteria, parasites, viruses, tumor cells, etc. Furthermore, their interactions with the endothelium are of special importance. Generally, lymphocyte adhesion and passage from the bloodstream to the lymphatic system occurs in the high endothelial venules of the lymph nodes. This way the lymphocytes can communicate with each other in the lymphatic system and search for foreign compounds after their recirculation to the bloodstream, thus fulfilling their role in the immune system. The reaction passes through the following steps: 1. Rolling, the flow of cells is slowed down by first making contacts to the endothelium via P-, E-, and L-selectins and their receptors; 2. Adhesion, after activation of leukocyte integrins, firm contacts are established between them and endothelium molecules of the Ig superfamily (e.g., LFA-1, Mac-1, VLA-4); 3. Flattening of the cells and diapedesis, adhering leukocytes crawl to an intercellular junction of the endothelium and then transmigrate to or even through the intercellular matrix. This is mediated by homophilic interactions of PECAM and CD31. (This definition may be outdated - see the DesignNote.)
MCID: MC00526994
PMOID: PMO:00014407
Subclass_of: Cell Motility Pathway
Synonym: Adhesion and Diapedesis of Lymphocytes
Tree Number: T4.2.13
database_cross_reference: NCI:C39142
database_cross_reference: NCI_BioC:C39142

Disease Pathway
type: Class
subclass of: Biochemical Pathway
Definition: A sequence of biological or biochemical events that are manifest during the course of a disease.
MCID: MC01393787
PMOID: PMO:00014408
Subclass_of: Biochemical Pathway
Tree Number: T4.3
database_cross_reference: NCI:C39701

Acute Myocardial Infarction Pathway
type: Class
subclass of: Disease Pathway
Definition: Myocardial infraction (MI) is the condition of irreversible necrosis of the heart muscle that results from prolonged ischemia. Nearly 1.5 million people in US sustain an MI each year, and this event proves fatal in approximately one third of patients. Approximately 90% of MI results from formation of an acute thrombus that obstructs an atherosclerotic coronary artery. The thrombus transforms a region of plaque narrowing to one of complete vessel occlusion. The responsible thrombus appears to be generated by interactions between the atherosclerotic plaque, the coronary endothelium, circulating platelets, and dynamic vasomotor tone of the vessel wall, all of which overwhelm natural protective mechanisms. The endogenous protective mechanisms against thrombosis include: 1) Inactivation of thrombin by antithrombin III (ATIII), the effectiveness of which is enhanced by binding of ATIII to heparin sulfate. The antithrombin binding region of commercial heparin consists of sulfated disaccharide units; 2) Inactivation of clotting factors Va and VIIIa by activated protein C (protein C*), an action that is enhanced by protein S. Protein C is activated by the thrombomodulin (TM)-thrombin complex; 3) Inactivation of factor VII/tissue factor complex by tissue factor pathway inhibitor (TFPI). Coumarin drugs (Warfarin) blocks the g-carboxylation of Glu residues in prothrombin and factors VII, IX and X which results in incomplete molecules that are biologically inactive in coagulation (left panel); 4) Lysis of fibrin clots by tissue plasminogen activator (tPA); 5) Inhibition of platelet activation by prostacyclin and EDRF-NO. Platelets adhere to exposed collagen and are activated at the site of endothelial damage in the blood vessel. Activated platelets release adenosine diphosphate (ADP), serotonin (5-HT), and thromboxane A2 (TXA2), which activate additional platelets. Binding of thrombin further activates the platelets. Three adjoining platelets are shown in the process of viscous …
MCID: MC01393739
PMOID: PMO:00014409
Subclass_of: Disease Pathway
Synonym: Acute Myocardial Infarction
Tree Number: T4.3.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38985
database_cross_reference: NCI_BioC:C38985

Allograft Rejection Pathway
type: Class
subclass of: Disease Pathway
Definition: After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
MCID: MC01394145
PMOID: PMO:00014410
Subclass_of: Disease Pathway
Synonym: Allograft rejection
Tree Number: T4.3.2
database_cross_reference: NCI:C91452
database_cross_reference: NCI_KEGG:C91452

Arrhythmogenic Right Ventricular Cardiomyopathy Pathway
type: Class
subclass of: Disease Pathway
Definition: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are progressive myocyte loss and fibrofatty replacement, with a predilection for the right ventricle. A number of genetic studies have identified mutations in various components of the cardiac desmosome that have important roles in the pathogenesis of ARVD/C. Disruption of desmosomal function by defective proteins might lead to death of myocytes under mechanical stress. The myocardial injury may be accompanied by inflammation. Since regeneration of cardiac myocytes is limited, repair by fibrofatty replacement occurs. Several studies have implicated that desmosome dysfunction results in the delocalization and nuclear translocation of plakoglobin. As a result, competition between plakoglobin and beta-catenin will lead to the inhibition of Wnt/beta-catenin signaling, resulting in a shift from a myocyte fate towards an adipocyte fate of cells. The ryanodine receptor plays a crucial part in electromechanical coupling by control of release of calcium from the sarcoplasmic reticulum into the cytosol. Therefore, defects in this receptor could result in an imbalance of calcium homeostasis that might trigger cell death.
MCID: MC01394152
PMOID: PMO:00014411
Subclass_of: Disease Pathway
Synonym: ARVC Pathway
Synonym: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Tree Number: T4.3.3
database_cross_reference: NCI:C91454
database_cross_reference: NCI_KEGG:C91454

Asthma Pathway
type: Class
subclass of: Disease Pathway
Definition: Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into Th2 cells, a process that is promoted by interleukin 4 (IL-4). Activated Th2 cells stimulate B cells to produce IgE antibodies in response to IL-4 and IL-13. IgE binds the high affinity IgE receptor at the surface of mast cells, the proliferation and differentiation of which is promoted by IL-9.The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Activated mast cells and Th2 cells also induce the production of IL-5. IL-5 travels to the bone marrow and regulates the differentiation and egress of eosinophils from the bone marrow into the blood. Moreover activated mast cells and Th2 cells in the lung generate the cytokines interleukin IL-4, IL-13 and tumour necrosis factor (TNF)-alpha. These cytokines stimulate the generation of eotaxin by lung epithelial cells, fibroblasts and smooth muscle cells. Eotaxin then stimulates the selective recruitment of eosinophils from the airway microvessels into the lung tissue. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation.
MCID: MC01394266
PMOID: PMO:00014412
Subclass_of: Disease Pathway
Synonym: Asthma
Tree Number: T4.3.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91488
database_cross_reference: NCI_KEGG:C91488

Autoimmune Thyroid Disease Pathway
type: Class
subclass of: Disease Pathway
Definition: The classification of autoimmune thyroid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroiditis or primary myxedema.
MCID: MC01393830
PMOID: PMO:00014413
Subclass_of: Disease Pathway
Synonym: Autoimmune thyroid disease
Tree Number: T4.3.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91510
database_cross_reference: NCI_KEGG:C91510

Cancer Pathway
type: Class
subclass of: Disease Pathway
MCID: MC01394217
PMOID: PMO:00014414
Subclass_of: Disease Pathway
Synonym: Human Diseases; Cancers
Synonym: Pathways in cancer
Tree Number: T4.3.6
database_cross_reference: NCI:C91436
database_cross_reference: NCI_KEGG:C91436

Acute Myeloid Leukemia Pathway
type: Class
subclass of: Cancer Pathway
Definition: Two major types of genetic events are crucial for the molecular pathogenesis of acute myeloid leukemias (AML): activating mutations of signal transduction intermediates and alterations in myeloid transcription factors governing hematopoietic differentiation. Both aberrant and constitutive activation of signal transduction molecules are found in about 50% of primary AML bone marrow samples, and seem to contribute to the increased proliferation and apoptosis resistance. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Specific haematopoietic transcription factors are crucial for differentiation to particular lineages during normal differentiation, but are frequently disrupted in AML. Some mechanisms of disruption involve the effect of fusion proteins that are generated by chromosomal translocations on haematopoietic transcription factors. In other cases, the transcription factors themselves are mutated.
MCID: MC01393757
PMOID: PMO:00014415
Subclass_of: Cancer Pathway
Synonym: AML Pathway
Synonym: Acute myeloid leukemia
Tree Number: T4.3.6.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91526
database_cross_reference: NCI_KEGG:C91526

Basal Cell Carcinoma Pathway
type: Class
subclass of: Cancer Pathway
Definition: The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. Normally, ligand-dependent signaling by Hedgehog (Hh) homologs proceeds through binding to the Patched receptor. This binding relieves the Patched-mediated inhibition of signaling through the Smoothened (SMOH) gene product. This signaling ultimately results in the dissociation of the Gli1 transcription factor from an inhibitory complex in the cytoplasm, its subsequent translocation to the nucleus, and activation of target gene expression. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
MCID: MC01393873
PMOID: PMO:00014416
Subclass_of: Cancer Pathway
Synonym: Basal cell carcinoma
Tree Number: T4.3.6.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91513
database_cross_reference: NCI_KEGG:C91513

Bladder Cancer Pathway
type: Class
subclass of: Cancer Pathway
Definition: Bladder cancers arise and progress along two distinctive pathways. The first of these is often preceded by simple and papillary hyperplasia and exhibits a tumour morphology that is low-grade, superficial and papillary. Papillary carcinoma has a tendency to recur locally, but rarely invades and metastasizes. These tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. The second tumour pathway is characterized by high-grade muscle-invasive tumours, which either originate from flat carcinoma in situ (CIS)/severe dysplasia or arise de novo. Over half of these tumours show defects in the tumour suppressors p53 and/or the retinoblastoma protein (RB) genes and pathways, and over 50% of these tumours progress to local and distant metastases. Some of the cell cycle-related molecules show evidence of epigenetic modulation through aberrant promoter hypermethylation in invasive bladder cancer. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF).
MCID: MC01394320
PMOID: PMO:00014417
Subclass_of: Cancer Pathway
Synonym: Bladder cancer
Tree Number: T4.3.6.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91458
database_cross_reference: NCI_KEGG:C91458

Chronic Myeloid Leukemia Pathway
type: Class
subclass of: Cancer Pathway
Definition: Chronic myelogenous leukaemia (CML) is a biphasic disease, initiated by expression of the BCR/ABL fusion gene product in self-renewing, haematopoietic stem cells (HSCs). HSCs can differentiate into common myeloid progenitors (CMPs), which then differentiate into granulocyte/macrophage progenitors (GMPs). HSCs can also differentiate into common lymphoid progenitors (CLPs), which are the progenitors of lymphocytes such as T cells and B cells. The initial chronic phase of CML (CML-CP) is characterized by a massive expansion of the granulocytic-cell series. Acquisition of additional genetic mutations beyond expression of BCR/ABL causes the progression of CML from chronic phase to blast phase (CML-BP), characterized by an accumulation of myeloid or lymphoid blast cells.
MCID: MC01394304
PMOID: PMO:00014418
Subclass_of: Cancer Pathway
Synonym: CML Pathway
Synonym: Chronic myeloid leukemia
Tree Number: T4.3.6.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91465
database_cross_reference: NCI_KEGG:C91465

Colorectal Cancer Pathway
type: Class
subclass of: Cancer Pathway
Definition: Classically, colorectal cancer (CRC) has been believed to develop from normal mucosa through the premalignant adenoma by the step-wise accumulation of mutations. All CRC display either microsatellite instability (MSI) or chromosome instability (CIN). MSI occurs in 15% of colon cancers and results from inactivation of the DNA mismatch repair (MMR) system by either MMR gene mutations or hypermethylation of the MLH1 promoter. MSI promotes tumorigenesis through generating mutations in target genes that possess coding microsatellite repeats, such as beta-catenin, TGFBR2 and BAX. CIN is found in the majority of colon cancers and leads to a different pattern of gene alterations that contribute to tumor formation. Genes involved in CIN are those coding for APC, K-ras, SMAD4 and p53.
MCID: MC01394308
PMOID: PMO:00014419
Subclass_of: Cancer Pathway
Synonym: CRC Pathway
Synonym: Colorectal cancer
Tree Number: T4.3.6.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91466
database_cross_reference: NCI_KEGG:C91466

Endometrial Cancer Pathway
type: Class
subclass of: Cancer Pathway
Definition: Two types of endometrial carcinoma are distinguished with respect to biology and clinical course.
MCID: MC01393763
PMOID: PMO:00014420
Subclass_of: Cancer Pathway
Synonym: Endometrial cancer
Tree Number: T4.3.6.6
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91528
database_cross_reference: NCI_KEGG:C91528

Glioblastoma Multiforme Pathway
type: Class
subclass of: Cancer Pathway
Definition: Glioblastoma multiforme (GBM) formation is either de novo (primary GBMs) or due to the progression of a lower grade glioma to a higher grade one through the acquisition of additional mutations (secondary GBMs). In primary GBM, disruption of the p53 pathway often occurs through loss of ARF, or less frequently through amplification of MDM2. Disruption of the RB pathway occurs through loss of INK4A. Amplification and/or mutation of the epidermal growth factor receptor (EGFR) is the most frequently detected genetic defect that is associated with primary GBM. In secondary GBM, loss of p53 and activation of the growth-factor-receptor-tyrosine-kinase signaling pathway (such as through overexpression of PDGF/PDGFR) initiates tumour formation, whereas disruption of the retinoblastoma (RB) pathway contributes to the progression of tumour development. Loss of PTEN has been implicated in both pathways, although it is much more common in the pathogenesis of primary GBM.
MCID: MC01394268
PMOID: PMO:00014421
Subclass_of: Cancer Pathway
Synonym: GBM Pathway
Synonym: Glioma
Synonym: Glioma Pathway
Tree Number: T4.3.6.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91479
database_cross_reference: NCI_KEGG:C91479

Melanoma Pathway
type: Class
subclass of: Cancer Pathway
Definition: Five distinct stages have been proposed in the evolution of melanoma on the basis of histological criteria: common acquired and congenital nevi without dysplastic changes; dysplastic nevi with structural and architectural atypia; radial-growth phase (RGP) melanoma; vertical-growth phase (VGP) melanoma; and metastatic melanoma. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Moreover, melanoma development is strongly associated with inactivation of the p16INK4a/CDK4,6/pRb and p14ARF/HMD2/p53 tumor suppressor pathways. The vertical-growth phase and metastatic melanoma are notable for striking changes in the control of cell adhesion. Recently, amplification of the MITF gene was demonstrated in 10% of primary melanomas and 20% of metastatic melanomas, suggesting that MITF is a melanoma oncogene.
MCID: MC01394352
PMOID: PMO:00014422
Subclass_of: Cancer Pathway
Synonym: Melanoma
Tree Number: T4.3.6.8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91477
database_cross_reference: NCI_KEGG:C91477

Non-Small Cell Lung Cancer Pathway
type: Class
subclass of: Cancer Pathway
Definition: Non-small-cell lung cancer (NSCLC) accounts for approximately 80% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS and c-erbB-2, and inactivation of tumor suppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactivate GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Overexpression of c-erbB-2 or EGFR leads to a proliferative advantage. Inactivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a gene inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6. Loss of p16INK4a expression is a common feature of NSCLC RAR-beta is a nuclear receptor that bears vitamin-A-dependent transcriptional activity. RASSF1A is able to form heterodimers with Nore-1, an RAS effector. Therefore, loss of RASSF1A might shift the balance of RAS activity towards a growth-promoting effect.
MCID: MC01394116
PMOID: PMO:00014423
Subclass_of: Cancer Pathway
Synonym: NSCLC Pathway
Synonym: Non-small cell lung cancer
Tree Number: T4.3.6.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91445
database_cross_reference: NCI_KEGG:C91445

Pancreatic Cancer Pathway
type: Class
subclass of: Cancer Pathway
Definition: Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands. Pancreatic ductal adenocarcinoma (PDA) show elevated expression of EGF receptors (e.g. HER2/neu) and their ligands (e.g. TGF-alpha) consistent with the presence of this autocrine loop. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signaling pathway.
MCID: MC01394084
PMOID: PMO:00014424
Subclass_of: Cancer Pathway
Synonym: Pancreatic cancer
Tree Number: T4.3.6.10
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91446
database_cross_reference: NCI_KEGG:C91446

Papillary Thyroid Carcinoma Pathway
type: Class
subclass of: Cancer Pathway
Definition: Papillary thyroid carcinoma (PTC), the most frequent neoplasia originating from the thyroid epithelium, accounts for about 80% of all thyroid cancers. Chimeric oncogenes, created by chromosomal rearrangements involving prevalently RET and, to a less extent, NTRK1 loci, are implicated in the development of papillary carcinoma. These are inappropriately expressed and stimulate constitutive signaling, bypassing the need for receptor activation by growth factors. Alternatively, mutant RAS directly stimulates BRAF, whereas mutant BRAF directly stimulates MEK.
MCID: MC01393680
PMOID: PMO:00014425
Subclass_of: Cancer Pathway
Synonym: PTC Pathway
Synonym: Thyroid Cancer Pathway
Synonym: Thyroid cancer
Tree Number: T4.3.6.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91496
database_cross_reference: NCI_KEGG:C91496

Prostate Cancer Pathway
type: Class
subclass of: Cancer Pathway
Definition: The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes that catalyze conjunction of glutathione with harmful, electrophilic molecules, thereby protecting cells from carcinogenic factors. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by such carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. After therapeutic reduction in the levels of testosterone and dihydrotestosterone, the emergence of androgen-independent prostate cancer has been associated with mutations in the androgen receptor (AR) that permit receptor activation by other ligands, increased expression of androgen receptors accompanying AR amplification, and ligand-independent androgen-receptor activation.
MCID: MC01393854
PMOID: PMO:00014426
Subclass_of: Cancer Pathway
Synonym: Prostate cancer
Tree Number: T4.3.6.12
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91517
database_cross_reference: NCI_KEGG:C91517

Renal Cell Carcinoma Pathway
type: Class
subclass of: Cancer Pathway
Definition: Renal cell carcinoma (RCC) is a heterogeneous term comprising a group of neoplasms of renal origin. There are 4 major histologic subtypes of RCC: conventional (clear cell RCC, 75%), papillary (15%), chromophobic (5%), and collecting duct (2%). Multiple genes are involved in the molecular pathogenesis of RCC. VHL is a tumor suppressor gene responsible for hereditary (von Hippel-Lindau) and sporadic variants of conventional (clear cell) RCC. In the absence of VHL, hypoxia-inducible factor alpha (HIF-alpha) accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. An oncogene, MET has been found to be mutant in cases of hereditary papillary renal cancer (HPRC), although the incidence of c-MET mutations is low in sporadic papillary RCC. Once activated, MET mediates a number of biological effects including motility, invasion of extracellular matrix, cellular transformation, prevention of apoptosis and metastasis formation. Mutations in the fumarate hydratase (FH) gene cause hereditary leiomyomatosis and renal cancer syndrome (HLRCC) papillary renal tumors, although the incidence of FH mutations in sporadic tumors is unknown. Loss of functional FH leads to accumulation of fumarate in the cell, triggering inhibition of HPH and preventing targeted pVHL-mediated degradation of HIF-alpha. BHD mutations cause the Birt-Hogg-Dube syndrome and its associated chromophobe, hybrid oncocytic, and conventional (clear cell) RCC. The incidence of BHD mutations in sporadic renal tumors is not known.
MCID: MC01393840
PMOID: PMO:00014427
Subclass_of: Cancer Pathway
Synonym: Renal cell carcinoma
Tree Number: T4.3.6.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91501
database_cross_reference: NCI_KEGG:C91501

Small Cell Lung Cancer Pathway
type: Class
subclass of: Cancer Pathway
Definition: Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 20% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumor suppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.
MCID: MC01393842
PMOID: PMO:00014428
Subclass_of: Cancer Pathway
Synonym: SCLC Pathway
Synonym: Small cell lung cancer
Tree Number: T4.3.6.14
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91502
database_cross_reference: NCI_KEGG:C91502

Cancer Susceptibility Pathway
type: Class
subclass of: Disease Pathway
Definition: BRCA1 and BRCA2 were identified genetically as breast cancer susceptibility genes when a single copy of the gene is mutated and are involved in the cellular response to DNA damage, including blocking cell cycle progression and inducing DNA repair to preserve the integrity of the genome during cell division. BRCA1 and BRCA2 induce double-stranded repair of breaks using homologous recombination, in part through activation of RAD51. BRCA1 acts as a ubiquitin ligase targeting the protein FancD2 that activates checkpoint control, integrating the ATM response to ionizing radiation and the FA response to cross-linking agents like mitomycin C. Mutation of one of the several components of the FA complex involved in maintaining integrity of the genome leads to the condition Fanconi anemia. One member of the FA complex was recently identified as BRCA2, which leads to Fanconi anemia when both copies of the gene are mutated. Another related factor involved in the response of cells to DNA damage is the kinase ATM. ATM is mutated in patients with AT, a condition with many similar traits to Fanconi anemia. Like ATM, ATR serves as a checkpoint kinase that halts cell cycle progression and induces DNA repair when DNA is damaged. Loss of ATR results in a loss of checkpoint control in response to DNA damage, leading to cell death. Deletion of the ATR gene in mice is embryonic lethal. ATRIP is a protein that interacts with ATR and is a substrate for its kinase activity. ATRIP is required for ATR function, and removal of ATRIP also leads to a loss of checkpoint control of the cell cycle. ATR and ATM kinase targets include repair enzymes like Rad51, and the checkpoint kinases Chk1 and Chk2, as well as BRCA1 and BRCA2. The close relationship of the genes involved in breast cancer and Fanconi anemia has helped illuminate this signaling system, and may help lead to improved understanding and treatment of these conditions. (This definition may be outdated - see the DesignNote.)
MCID: MC00526058
PMOID: PMO:00014429
Subclass_of: Disease Pathway
Synonym: Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility
Tree Number: T4.3.7
database_cross_reference: NCI:C38997
database_cross_reference: NCI_BioC:C38997

Cardiac Hypertrophy Pathway
type: Class
subclass of: Disease Pathway
Definition: One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickness of the ventricular walls. Cardiac hypertrophy allows the heart to handle the increased stress caused by elevated blood pressure but is also a risk factor associated with heart disease. Cardiac hypertrophy results from cross-talk between G-protein coupled receptor signaling and the EGF receptor pathway. Several GPCR ligands are known to stimulate cardiac hypertrophy, including factors that regulate blood pressure such as angiotensin II and endothelin-1. These factors stimulate phospholipase C through Gq activation, and the production of 1P3 and diacylglycerol second messengers. PKC-delta is activated by DAG and interacts with the metalloproteinase ADAM12. ADAM12 cleaves the membrane-bound HB-EGF to release soluble EGF ligand that activates EGF receptor in myocardial cells. EGF receptor activation downstream through small G proteins and the MAP kinase pathway ultimately leads to cardiac hypertrophy. Signals by GPCR ligands such as angiotensin II result in transcriptional translation of immediate early genes like fos and other genes involved in long-term remodeling of heart tissue and the physiological response to stress in the heart such as the atrial natriuretic factor. Factors such as the AKT kinase, reactive oxygen species (ROS) and NE-kB also are involved in signaling that leads to hypertrophy, although their role is not yet clear. Blocking this pathway at various steps may prevent heart disease through the prevention of cardiac hypertrophy, but may also have other consequences. (This definition may be outdated - see the DesignNote.)
MCID: MC00526081
PMOID: PMO:00014430
Subclass_of: Disease Pathway
Synonym: Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
Tree Number: T4.3.8
database_cross_reference: NCI:C39011
database_cross_reference: NCI_BioC:C39011

Dilated Cardiomyopathy Pathway
type: Class
subclass of: Disease Pathway
Definition: Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac death from ventricular arrhythmia. Genetically inherited forms of DCM ("familial" DCM) have been identified in 25-35% of patients presenting with this disease, and the inherited gene defects are an important cause of "familial" DCM. The pathophysiology may be separated into two categories: defects in force generation and defects in force transmission. In cases where an underlying pathology cannot be identified, the patient is diagnosed with an "idiopathic" DCM. Current hypotheses regarding causes of "idiopathic" DCM focus on chronic viral myocarditis and/or on autoimmune abnormalities. Viral myocarditis may progress to an autoimmune phase and then to progressive cardiac dilatation. Antibodies to the beta1-adrenergic receptor (beta1AR), which are detected in a substantial number of patients with "idiopathic" DCM, may increase the concentration of intracellular cAMP and intracellular Ca2+, a condition often leading to a transient hyper-performance of the heart followed by depressed heart function and heart failure.
MCID: MC01394361
PMOID: PMO:00014431
Subclass_of: Disease Pathway
Synonym: DCM Pathway
Synonym: Dilated cardiomyopathy
Tree Number: T4.3.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91470
database_cross_reference: NCI_KEGG:C91470

Graft-Versus-Host Disease Pathway
type: Class
subclass of: Disease Pathway
Definition: Graft-versus-host disease (GVHD) pathophysiology can be summerized in a three-step process. During step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues and induction of inflammatory cytokines [tumour necrosis factor (TNF-alpha) and interleukin (IL-1)] secretion. Increased expression of major histocompatibility complex (MHC) antigens and adhesion molecules leads to enhancement of the recognition of host MHC and/or minor histocompatibility antigens by mature donor T cells.
MCID: MC01394272
PMOID: PMO:00014432
Subclass_of: Disease Pathway
Synonym: GVHD Pathway
Synonym: Graft-versus-host disease
Tree Number: T4.3.10
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91481
database_cross_reference: NCI_KEGG:C91481

Hypertrophic Cardiomyopathy Pathway
type: Class
subclass of: Disease Pathway
Definition: Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological features of myocyte hypertrophy, myofibrillar disarray, and interstitial fibrosis. HCM is one of the most common inherited cardiac disorders, with a prevalence in young adults of 1 in 500. Hundreds of mutations in 11 genes that encode protein constituents of the sarcomere have been identified in HCM. These mutations increase the Ca2+ sensitivity of cardiac myofilaments. Increased myofilament Ca2+ sensitivity is expected to increase the ATP utilization by actomyosin at submaximal Ca2+ concentrations, which might cause an imbalance in energy supply and demand in the heart under severe stress. The inefficient use of ATP suggests that an inability to maintain normal ATP levels could be the central abnormality. This theory might be supported by the discovery of the role of a mutant PRKAG2 gene in HCM, which in active form acts as a central sensing mechanism protecting cells from depletion of ATP supplies. The increase in the myofilament Ca2+ sensitivity well account for the diastolic dysfunction of model animals as well as human patients of HCM. It has been widely proposed that left ventricular hypertrophy is not a primary manifestation but develops as compensatory response to sarcomere dysfunction.
MCID: MC01394261
PMOID: PMO:00014433
Subclass_of: Disease Pathway
Synonym: HCM Pathway
Synonym: Hypertrophic cardiomyopathy (HCM)
Tree Number: T4.3.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91484
database_cross_reference: NCI_KEGG:C91484

Hypoxia Pathway
type: Class
subclass of: Disease Pathway
Definition: Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, hypoxia does not induce p53-dependent cell cycle arrest, suggesting that p53 activity is differentially regulated by these two stresses. Hypoxia induces p53 protein accumulation, but in contrast to DNA damage, hypoxia fails to induce endogenous downstream p53 effector mRNAs and proteins, such as p21, Bax, CIP1, WAF1, etc. Hypoxia does not inhibit the induction of p53 target genes by ionizing radiation, indicating that p53-dependent transactivation requires a DNA damage-inducible signal that is lacking under hypoxic treatment alone. The phosphatidylinositol 3-OH-kinase-Akt pathway inhibits p53-mediated transcription and apoptosis. Mdm2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 and serves as a good substrate for Akt. Mdm-2 targets the p53 tumor suppressor for ubiquitin-dependent degradation by the proteasome, but, in addition, the p53 transcription factor induces Mdm-2, thus, establishing a feedback loop. Hypoxia or DNA damage by abrogating binding of HIF-1 with VHL and p53 with Mdm-2, respectively, leads to stabilization and accumulation of transcriptionally active HIF-1 and p53. At the molecular level, DNA damage induces the interaction of p53 with the transcriptional activator p300 as well as with the transcriptional corepressor mSin3A. In contrast, hypoxia primarily induces an interaction of p53 with mSin3A, but not with p300. (This definition may be outdated - see the DesignNote.)
MCID: MC00523993
PMOID: PMO:00014434
Subclass_of: Disease Pathway
Synonym: Hypoxia and p53 in the Cardiovascular system
Tree Number: T4.3.12
database_cross_reference: NCI:C39179
database_cross_reference: NCI_BioC:C39179

Infectious Disease Pathway
type: Class
subclass of: Disease Pathway
Definition: A sequence of biological or biochemical events that are the result of contracting an infection.
MCID: MC01393882
PMOID: PMO:00014435
Subclass_of: Disease Pathway
Synonym: Infectious Disease
Tree Number: T4.3.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39738
database_cross_reference: NCI_KEGG:C39738

Amoebiasis Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Entamoeba histolytica, an extracellular protozoan parasite, is a human pathogen that invades the intestinal epithelium. Infection occurs upon ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteinases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection, like amoebic liver abscess, by evading the immune response.
MCID: MC01393758
PMOID: PMO:00014436
Subclass_of: Infectious Disease Pathway
Synonym: Amoebiasis
Synonym: E. histolytica Infection Pathway
Synonym: Entamoeba histolytica Infection Pathway
Tree Number: T4.3.13.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91808
database_cross_reference: NCI_KEGG:C91808

Anthrax Toxin Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: One of the key causes of anthrax virulence is the action of three specific factors produced by the bacterium Bacillus anthracis. Even with successful antibiotic treatment, anthrax toxins can remain in the circulation and cause lethality. The toxins produced by anthrax bacteria are lethal factor (LF), protective antigen (PA) and edema factor (EF). The entry of toxin into cells begins with the recognition of a cellular receptor in the plasma membrane by PA. Proteolytic cleavage of cell-bound PA creates a smaller fragment that then multimerizes into a pore-like structure in the plasma membrane. The LF and EF proteins bind to the PA pre-pore, followed by internalization of the entire structure through receptor-mediated endocytosis. In the endosomal compartment, the acidic pH causes a conformational change that inserts PA fragments and releases LF and EF into the cytoplasm. In the cytoplasm, LF acts as a protease that cleaves MAP kinase kinase (MAPKK 1 and MAPKK 2), inhibiting pathways that rely on this kinase family and causing cell death. Edema factor is an adenylate cyclase that inhibits the immune response, including phagocytosis by macrophages. (This definition may be outdated - see the DesignNote.)
MCID: MC00523093
PMOID: PMO:00014437
Subclass_of: Infectious Disease Pathway
Synonym: Anthrax Toxin Mechanism of Action
Tree Number: T4.3.13.2
database_cross_reference: NCI:C38986
database_cross_reference: NCI_BioC:C38986

Bacterial Invasion of Epithelial Cell Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Many pathogenic bacteria can invade phagocytic and non-phagocytic cells, colonize them intracellularly, and then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signaling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
MCID: MC01393858
PMOID: PMO:00014438
Subclass_of: Infectious Disease Pathway
Synonym: Bacterial invasion of epithelial cells
Tree Number: T4.3.13.3
database_cross_reference: NCI:C91804
database_cross_reference: NCI_KEGG:C91804

Botulin Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: The neuromuscular junction communicates action potentials from motor neurons across a synapse to skeletal muscle. When an action impulse arrives at the neuromuscular junction, the entry of calcium through voltage-gated calcium channels causes synaptic vesicles to fuse with the presynaptic plasma membrane and release the neurotransmitter acetylcholine into the synaptic cleft. Acetylcholine diffuses across the cleft and binds to muscle acetylcholine receptors, causing depolarization and an action potential that travels throughout the length of the muscle cell triggering muscle contraction. The release of neurotransmitter at the synapse involves the fusion of synaptic vesicles with the neuronal plasma membrane and requires several proteins that act together to form a synaptic fusion complex. These proteins, collectively called SNARE proteins, include SNAP-25, syntaxin, and synaptobrevin. Homologs of these proteins are also involved in membrane fusion in other aspects of vesicle trafficking. Synaptobrevin (also called VAMP2) is localized at the synaptic vesicle membrane, while SNAP-25 and syntaxin are associated with the plasma membrane. Calcium release causes the formation of a complex, bringing the synaptic vesicle in close proximity with the plasma membrane and allowing fusion of the membranes. Biological toxins often disrupt nervous function, particularly the action of motor neurons. Botulinum toxin, synthesized by the bacteria Clostridium botulinum, is one of the most potent toxins known and acts by blocking neurotransmitter release at the neuromuscular junction. Botulinum toxin is a protein composed of two subunits joined by a disulfide bond, a 100 kD heavy subunit and a 50 kD light subunit that is a protease. There are seven serotypes of botulinum with distinct toxins. Tetanus toxin is similar in structure and in mechanism of action to botulinum toxin. The toxins can be absorbed in the intestine to travel in the blood to its site of action, at the neuromuscular j…
MCID: MC00523286
PMOID: PMO:00014439
Subclass_of: Infectious Disease Pathway
Synonym: Blockade of Neurotransmitter Relase by Botulinum Toxin
Tree Number: T4.3.13.4
database_cross_reference: NCI:C39007
database_cross_reference: NCI_BioC:C39007

Botulinum Toxin Pathway
type: Class
subclass of: Infectious Disease Pathway
MCID: MC01394164
PMOID: PMO:00014440
Subclass_of: Infectious Disease Pathway
Synonym: Effects of Botulinum toxin
Tree Number: T4.3.13.5
database_cross_reference: NCI:C91578
database_cross_reference: NCI_PID:C91578

Cellular Anthrax Toxin Pathway
type: Class
subclass of: Infectious Disease Pathway
MCID: MC01394232
PMOID: PMO:00014441
Subclass_of: Infectious Disease Pathway
Synonym: Cellular roles of Anthrax toxin
Tree Number: T4.3.13.6
database_cross_reference: NCI:C91562
database_cross_reference: NCI_PID:C91562

Chagas Disease Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed.
MCID: MC01393754
PMOID: PMO:00014442
Subclass_of: Infectious Disease Pathway
Synonym: Chagas disease
Synonym: Chagas disease (American trypanosomiasis)
Synonym: T. cruzi Infection Pathway
Synonym: Trypanosoma cruzi Infection Pathway
Tree Number: T4.3.13.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91525
database_cross_reference: NCI_KEGG:C91525

Epithelial Cell Signaling Pathway in Helicobacter pylori Infection
type: Class
subclass of: Infectious Disease Pathway
Definition: Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA).
MCID: MC01393760
PMOID: PMO:00014443
Subclass_of: Infectious Disease Pathway
Synonym: Epithelial cell signaling in Helicobacter pylori infection
Synonym: H. pylori Virulence Factor Pathway
Tree Number: T4.3.13.8
database_cross_reference: NCI:C91527
database_cross_reference: NCI_KEGG:C91527

HBx Signaling Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Hepatitis B is a small DNA virus that contains only 4 open reading frames in its genome. Three of these ORFs have been identified as the envelope, capsid and polymerase genes, while the function of the fourth has remained unknown until recently. The fourth reading frame has been called the X gene and produces HBx protein that is essential for viral replication in liver cells and acts broadly to activate a variety of transcription factors. One hypothesis of HBx activity has been that it enters the nucleus to act as a transcriptional regulator. One piece of evidence supporting this mechanism of HBx action is that HBx interacts with the transcription factor CREB and increases its DNA-binding activity. This mechanism does not explain all of the effects of HBx however. Another hypothesis for the HBx mechanism of action is that HBx increases calcium release into the cytoplasm. This mechanism of action is consistent with the variety of transcription factors and kinases affected by HBx since calcium signaling affects many different signaling pathways. HBx does not appear to interact directly with Ras or protein kinases but does appear to activate the calcium activate protein kinase Pyk2. A dominant negative form of Pyk2 blocks HBx activity and the involvement of calcium in HBx activation of Pyk2 is indicated by the action of several molecular probes that alter cytosolic calcium signaling. BAPTA-AM chelates cytosolic and blocks HBx action. Cyclosporin A blocks mitochondrial calcium signaling and also blocked HBx signaling. CGP37157 is a compound that blocks the mitochondrial sodium calcium pump and also blocks hepatitis B viral replication, indicating that mitochondrial calcium signaling is the target of HBx function. Compounds that elevate cytoplasmic calcium levels (valinomycin and thapsigargin) increase the rate of replication of viruses that lack HBx, further supporting the role of HBx as an inducer of intracellular calcium signaling. The mechanism by which HBx causes ca…
MCID: MC00523853
PMOID: PMO:00014444
Subclass_of: Infectious Disease Pathway
Synonym: Calcium Signaling by HBx of Hepatitis B virus
Tree Number: T4.3.13.9
database_cross_reference: NCI:C39100
database_cross_reference: NCI_BioC:C39100

HIV-1 Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Cells have many defenses against viral infection, including intracellular proteins that interfere with viral replication. Just as mammals have evolved defenses against viruses, viruses have evolved countermeasures to defeat cellular defenses. Vif is a viral gene produced by the HIV virus whose molecular function has remained unclear, but many aspects of its behavior have been revealed. Vif proteins are required for the production of infectious viral particles in many cells, acting to repress an intracellular T cell antiviral defense. Vif interacts with viral RNA and may help package viral genomic RNA to form mature virus. Some Vif is also found packaged in virion particles and multimerization of Vif appears to play a role in its activity. CEM15 is a cellular protein that provides an intracellular defense against HIV replication in T cells by acting against Vif. Viruses lacking the Vif gene are only able to replicate in cells lacking CEM15 and expressing CEM15 in cells is sufficient to prevent HIV infection. Although this research partially clarifies the function of Vif in HIV replication, many questions remain to be answered. CEM15 may or may not interact directly with Vif to block its function. Vif has been shown to bind to HIV genomic RNA and CEM15 has homology to cytidine deaminases, enzymes that edit RNA. This homology suggests that CEM15 may itself have an enzyme activity that modifies HIV RNA to render virus non-infectious. (This definition may be outdated - see the DesignNote.)
MCID: MC00523857
PMOID: PMO:00014445
Subclass_of: Infectious Disease Pathway
Synonym: HIV-1 defeats host-mediated resistance by CEM15
Tree Number: T4.3.13.10
database_cross_reference: NCI:C39265
database_cross_reference: NCI_BioC:C39265

HIV-1 Nef
type: Class
subclass of: Infectious Disease Pathway
MCID: MC01393642
PMOID: PMO:00014446
Subclass_of: Infectious Disease Pathway
Synonym: HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha
Synonym: HIV-1 Nef: Negative effector of Fas and TNF-alpha
Tree Number: T4.3.13.11
database_cross_reference: NCI:C91612
database_cross_reference: NCI_PID:C91612

Human Cytomegalovirus Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: To replicate in host cell, viruses commandeer cellular signaling pathways. Cytomegalovirus (CMV) is a DNA virus that is widespread in the population but usually causes disease only in immunocompromised individuals and is also a viral cause of birth defects. One of the actions of CMV in the host cell is to stimulate MAP kinase pathways. Both p38 and ERK kinases are activated by CMV infection through activation of map kinase kinases and inhibition of phosphatases. One result of Map kinase activation by CMV is activation of transcription of viral genes, increasing the production of viral gene products. Both p38 and ERK kinases contribute to the activation of viral genes by cellular transcription factors acting through the viral UL4 promoter at upstream and basal transcription elements. Another target of prolonged p38 activation during infection is Rb, contributing to viral replication. Activation of MKK1 and MKK2 leads to Erk1 and Erk2 activation, and phosphorylation of downstream targets. The MEKK1 kinase regulates the immediate early promoter indirectly through downstream kinase signaling and perhaps more directly through activation of NF-kB. Map kinase pathways activated by CMV converge on increased transcription of viral genes and increased replication of the viral genome. Better understanding of the mechanisms involved in the interaction of CMV with cellular signaling machinery will provide improved ways to treat CMV-mediated disease. (This definition may be outdated - see the DesignNote.)
MCID: MC00523946
PMOID: PMO:00014447
Subclass_of: Infectious Disease Pathway
Synonym: Human Cytomegalovirus and Map Kinase Pathways
Tree Number: T4.3.13.12
database_cross_reference: NCI:C39101
database_cross_reference: NCI_BioC:C39101

Leishmaniasis Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and proliferate intracellularly by deactivating the macrophage. Successful infection of Leishmania is achieved by alteration of signaling events in the host cell, leading to enhanced production of the autoinhibitory molecules like TGF-beta and decreased induction of cytokines such as IL12 for protective immunity. Nitric oxide production is also inhibited. In addition, defective expression of major histocompatibility complex (MHC) genes silences subsequent T cell activation mediated by macrophages, resulting in abnormal immune responses.
MCID: MC01393697
PMOID: PMO:00014448
Subclass_of: Infectious Disease Pathway
Synonym: Leishmaniasis
Tree Number: T4.3.13.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91491
database_cross_reference: NCI_KEGG:C91491

Malaria Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Plasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop into the merozoite form. Sporozoite invasion of hepatocytes is mediated by parasite surface protein like CSP. Subsequent infection into red blood cells (RBCs) by merozoites causes malaria disease via aberrant cytokine production and sequestration of parasite-infected red blood cells (pRBCs) to host endothelium. Microvasculature sequestration in the brain brings about cerebral malaria that can result in death or persisting neurological impairment. PfEMP1 has been suggested as the key adhesive molecule of pRBCs.
MCID: MC01393755
PMOID: PMO:00014449
Subclass_of: Infectious Disease Pathway
Synonym: Malaria
Synonym: Plasmodium Infection Pathway
Synonym: Plasmodium sp. Infection Pathway
Tree Number: T4.3.13.14
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91807
database_cross_reference: NCI_KEGG:C91807

NFKB Activation Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: The role of Hemophilus influenzae in ear infections and chronic obstructive pulmonary disease includes the induction of an inflammatory response through activation of the transcription factor NF-kB. In addition to activation of inflammatory cytokine genes like IL-1 and TNF, H. influenzae activates TLR2 expression and genes involved in mucus production. Hemophilus influenzae activates NF-kB by multiple mechanisms, starting with activation of the Toll-like receptor 2 (TLR2) by the p16 protein in the H. influenzae outer membrane. TLR2 plays a key role in innate immune responses and is expressed in high levels in lymphoid cells as well as low levels in epithelial cells. The role of TLR2 was supported by blocking NF-kB activation with a dominant negative TLR2 and increasing it with transfection of a normal TLR2 gene. TLR2 in turn activates TAK1, which activates two divergent signaling pathways. One of these pathways leads to IkB kinase activation, IkB phosphorylation, and degradation, releasing the NF-kB heterodimer to translocate into the nucleus and activate transcription of target genes. In the alternate pathway, TAK1 also activates NF-kB through a Map kinase pathway, activating p38 and NF-kB in a nuclear translocation independent manner. Investigation of the mechanisms of H. influenzae signaling involved in NF-kB activation may provide the information needed to develop better treatments for inflammatory conditions caused by this pathogen. Other pathways modulate the role of NF-kB in H. influenzae pathogenesis. Glucocorticoids, widely used as anti-inflammatory drugs, increase TLR2 activation by H. influenzae through the NIK/I-kB kinase pathway, while they repress the p38 dependent activation of NF-kB. The repression of the p38 pathway by glucocorticoids occurs through activation of the MAP kinase phosphatase-1 (MKP-1) which dephosphorylates and deactivates p38. Another aspect of the inflammatory response to H. influenzae infection is the production of excessive mucus,…
MCID: MC00524575
PMOID: PMO:00014450
Subclass_of: Infectious Disease Pathway
Synonym: NFkB activation by Nontypeable Hemophilus influenzae
Tree Number: T4.3.13.15
database_cross_reference: NCI:C39173
database_cross_reference: NCI_BioC:C39173

Pathogenic Escherichia coli Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells.
MCID: MC01394341
PMOID: PMO:00014451
Subclass_of: Infectious Disease Pathway
Synonym: Pathogenic E. coli Infection Pathway
Synonym: Pathogenic Escherichia coli infection
Tree Number: T4.3.13.16
database_cross_reference: NCI:C91474
database_cross_reference: NCI_KEGG:C91474

Salmonella Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Pathogenic Salmonella enter cells such as those of the intestinal epithelium by altering cellular cytoskeletal structure and inducing membrane ruffling of the infected cell. Salmonella is able to alter the cytoskeleton and membrane through the action of secreted bacterial Sip proteins, SopE, SopB, and SptP that are inserted into the cytosol of the infected cell. Sip proteins encoded by Salmonella are required for the action of SopE and for the invasion of epithelial cells. SipA stabilizes actin filaments, inducing membrane ruffling and perhaps focusing membrane changes where bacteria are localized to allow their entry. SipC produces a similar effect on actin filaments and cytoskeletal structure. SopE acts as an exchange factor on Rac1 and Cdc42, two GTPases in the Rho family that regulate actin cytoskeleton. The activation of Rac2 and Cdc42 by Salmonella SopE induces changes in cytoskeleton structure that allow bacterial entry into the cell. SopB is another salmonella protein that acts as an inositol polyphosphate phosphatase and also stimulates Cdc42 and Rac1. One of the cellular targets of both Cdc42 and Rac1 that affects actin structure is the Arp2/3 complex. Cdc42 and Rac1 activate Wasp, which activates Arp2/3. Activated Arp2/3 induces the formation of actin Y branches, which in combination with changes in actin caused by SipA and SipC help to form lamellipodia, and causes membrane ruffling, leading to entry of Salmonella into the affected cell. After the initial infection, cells quickly return to their normal morphology, a process that depends on the action of the bacterial protein SptP. While SopE acts as an exchange factor, SptP acts as a GTPase activating protein to inactivate Rac1 and Cdc42 once again. This inactivation of the original entry mechanism provides an example of the delicate balance between infectious organisms and their host. (This definition may be outdated - see the DesignNote.)
MCID: MC00527531
PMOID: PMO:00014452
Subclass_of: Infectious Disease Pathway
Synonym: How does salmonella hijack a cell
Tree Number: T4.3.13.17
database_cross_reference: NCI:C39227
database_cross_reference: NCI_BioC:C39227

SARS Coronavirus Protease Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Severe Acute Respiratory Syndrome (SARS) has affected thousands of individuals, causing fever, and pneumonia with a mortality rate estimated at 10-18%. Human coronaviruses cause mild respiratory illness and account for about a third of all cases of the common cold. A novel coronavirus has been identified as the causative agent of SARS and its genome has been sequenced. The enveloped SARS virus contains a large plus strand RNA genome, approximately 30,000 nucleotides. Examination of the SARS coronavirus sequences reveals that the rep gene covers over 20,000 nucleotides and encodes two overlapping polyproteins cleaved by viral proteases into smaller protein products. Translation of the longer polyprotein encoded by the rep gene requires a ribosomal frameshift. Other viral genes are predicted to encode the transmembrane spike protein S involved in viral fusion with host cells, the envelope protein E, the membrane protein M and the nucleocapsid protein N that binds to the RNA genome as well as several additional open reading frames with unknown functions. Viral entry into the cell is followed by translation of the viral rep gene, which codes for a viral protease within the polyprotein, Mpro or 3CLpro. The SARS 3CLpro has also been verified in vitro to cleave after the Gln residue at Leu-Gln-(Ser, Ala, Gly). Polypeptides released from the polyproteins by the main viral protease Mpro or 3CLpro include the viral polymerase and a protease. Both products are essential for viral replication and transcription. Structural crystals of a porcine coronavirus protease with a transition state inhibitor suggest that inhibitors of the distantly related rhinovirus protease like the drug AG7088 may be modified to produce drugs that block the SARS protease and viral replication. Blocking entry of the SARS virus into cells, involving recognition of cellular receptors by the S spike protein, may provide another strategy for the development of drugs to treat SARS. (This definition may be ou…
MCID: MC00527502
PMOID: PMO:00014453
Subclass_of: Infectious Disease Pathway
Synonym: SARS Coronavirus Protease
Tree Number: T4.3.13.18
database_cross_reference: NCI:C39229
database_cross_reference: NCI_BioC:C39229

Shigellosis Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestinal epithelium by exploiting epithelial-cell functions and circumventing the host innate immune response. During basolateral entry into the host-cell cytoplasm, Shigella deliver a subset of effectors into the host cells through the type III secretion system. The effectors induce membrane ruffling through the stimulation of the Rac1-WAVE-Arp2/3 pathway, enabling bacterial entry into the epithelial cells. During multiplication within the cells, Shigella secrete another subset of effectors. VirG induces actin polymerization at one pole of the bacteria, allowing the bacteria to spread intracellularly and to infect adjacent cells. OspF, OspG and IpaH(9.8) downregulate the production of proinflammatory cytokines such as IL-8, helping bacteria circumvent the innate immune response.
MCID: MC01393753
PMOID: PMO:00014454
Subclass_of: Infectious Disease Pathway
Synonym: Shigella Infection Pathway
Synonym: Shigellosis
Tree Number: T4.3.13.19
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91806
database_cross_reference: NCI_KEGG:C91806

Vibrio cholerae Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Cholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, the entire CTX complex is carried from plasma membrane (PM) to endoplasmic reticulum (ER). In the ER, the A-chain (CTXA) is recognized by protein disulfide isomerase (PDI), unfolded, and delivered to the membrane where the membrane-associated ER-oxidase, Ero1, oxidizes PDI to release the CTXA into the protein-conducting channel, Sec61. CTXA is then retro-translocated to the cytosol and induces water and electrolyte secretion by increasing cAMP levels via adenylate cyclase (AC) to exert toxicity.
MCID: MC01394303
PMOID: PMO:00014455
Subclass_of: Infectious Disease Pathway
Synonym: V. cholera Infection Pathway
Synonym: Vibrio cholerae infection
Tree Number: T4.3.13.20
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91464
database_cross_reference: NCI_KEGG:C91464

Viral Myocarditis Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is still considered the dominant etiological agent. Myocarditis may be caused by direct cytopathic effects of virus, a pathologic immune response to persistent virus, or autoimmunity triggered by the viral infection. The virus enters the myocyte through internalization of the coxsackie-adenoviral receptor (CAR) and its coreceptor, decay-accelerating factor (DAF). Viral proteases cleave various proteins in the host cell. One example is viral protease 2A, which cleaves eukaryote initiation factor 4G (eIF4G) and the dystrophin protein, resulting in a complete shutdown of cap-dependent RNA translation and cytoskeletal destruction in infected cardiomyocytes, respectively. CVB3 also cleaves the member of the Bcl-2 family Bid, leading to apoptosis. CVB3 infection also induces the cleavage of cyclin D protein through a proteasome-dependent pathway, leading to the host cell-growth arrest. Viral infection and necrosis of myocytes may lead to the release of intracellular antigens, resulting in activation of self-reactive T cells. CVB infection is a significant cause of dilated cardiomyopathy (DCM) as well as myocarditis. Epidemiologically, myocarditis underlies a significant portion of patients with DCM.
MCID: MC01394100
PMOID: PMO:00014456
Subclass_of: Infectious Disease Pathway
Synonym: Viral myocarditis
Tree Number: T4.3.13.21
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91441
database_cross_reference: NCI_KEGG:C91441

West Nile Virus Pathway
type: Class
subclass of: Infectious Disease Pathway
Definition: A description of the life cycle of the West Nile virus.
MCID: MC00577268
PMOID: PMO:00014457
Subclass_of: Infectious Disease Pathway
Synonym: West Nile Virus
Tree Number: T4.3.13.22
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39271
database_cross_reference: NCI_BioC:C39271

Insulin Resistance Pathway
type: Class
subclass of: Disease Pathway
Definition: The insulin resistance of type II diabetes appears to be caused in part by the presence of high levels of lipids in cells such as skeletal muscle where this would not normally be found. The presence of excess lipid stores in skeletal muscle cells interferes with energy metabolism, impairing glucose oxidation and insulin response. Skeletal muscle is one of the primary glucose-consuming tissues, giving it a central role in insulin resistance. The increased risk of diabetes associated with obesity may be caused by increased lipid deposits in skeletal muscle and liver, creating insulin resistance. Leptin is a peptide hormone secreted by adipose tissue that has been associated with many processes. One of the target tissues of leptin is the hypothalamus where it can act to regulate feeding behavior and metabolism. Another leptin target is skeletal muscle. Activation of leptin signaling in skeletal muscle activates the AMP-activated protein kinase (AMP-kinase), known to play a key role in signaling in response to nutrients throughout evolution. AMPK phosphorylates and inactivates the enzyme ACC, acetyl-CoA carboxylase. ACC catalyzes the production of malonyl-CoA from acetyl-CoA. Malonyl-CoA in turn is an inhibitor of the import of fatty acids into mitochondria by carnitine palmitoyltransferase I for oxidation and energy production. In the presence of leptin, AMPK is activated, ACC is inhibited, and malonyl-CoA levels fall, increasing the oxidation of fatty acids and reducing the lipid content of cells. The reduced lipid content in skeletal muscle allows insulin signaling and glucose consumption to return to their normal levels, reducing insulin resistance. (This definition may be outdated - see the DesignNote.)
MCID: MC00524123
PMOID: PMO:00014458
Subclass_of: Disease Pathway
Synonym: Reversal of Insulin Resistance by Leptin
Tree Number: T4.3.14
database_cross_reference: NCI:C39139
database_cross_reference: NCI_BioC:C39139

LDL Pathway
type: Class
subclass of: Disease Pathway
Definition: Low-density lipoprotein (LDL) is a plasma lipoprotein particle whose lipid component includes cholesterol and triglycerides and is commonly referred to as bad cholesterol due to its role promoting atherogenic heart disease. LDL in the plasma originates from very-low density lipoprotein (vLDL) produced by the liver with the apoprotein B-100. vLDL is converted to LDL by the action of lipoprotein lipase, an enzyme that hydrolyzes triglycerides in vLDL, removing them from the vLDL particle and releasing free fatty acids. The removal of triglycerides from vLDL by lipoprotein lipase leaves a greater proportion of cholesterol, increasing the density of the particle and changing it to LDL. Atherogenic heart disease involves the formation of plaques in arterial walls that narrow the arterial passage, restricting blood flow and increasing the risk of occlusion of blood flow by a myocardial infarction. One of the first steps in the development of atherogenic heart disease is the passage of LDL out of the arterial lumen and into the arterial wall. Once there, the lipids in LDL are chemically modified and oxidized. Oxidized LDL stimulates inflammatory signaling by neighboring endothelial cells, releasing chemokines and cytokines such as M-CSF and MCP-1 and recruiting monocytes into the arterial wall. Once there, monocytes differentiate into macrophages and internalize modified LDL. These macrophages continue to internalize LDL, becoming enlarged and full of lipid. These cells accumulate in tissue and are transformed into foam cells, dying and forming part of the atherogenic plaque. Therapeutic intervention in atherogenic heart disease focuses first on lowering plasma LDL levels through diet and medication. The statins are drugs commonly used to block cholesterol production and increase the expression of the LDL receptor by the liver, removing LDL from circulation. Blocking LDL oxidation may also protect against atherogenesis, and may be the mechanism by which antioxidants such a…
MCID: MC00526764
PMOID: PMO:00014459
Subclass_of: Disease Pathway
Synonym: Low-density lipoprotein (LDL) pathway during atherogenesis
Tree Number: T4.3.15
database_cross_reference: NCI:C39137
database_cross_reference: NCI_BioC:C39137

Maturity Onset Diabetes of the Young Pathway
type: Class
subclass of: Disease Pathway
Definition: About 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MODY).
MCID: MC01394137
PMOID: PMO:00014460
Subclass_of: Disease Pathway
Synonym: MODY
Synonym: MODY Pathway
Synonym: Maturity onset diabetes of the young
Synonym: Type II Diabetes Mellitus in Young Patients Pathway
Tree Number: T4.3.16
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91449
database_cross_reference: NCI_KEGG:C91449

Metabolic Syndrome Pathway
type: Class
subclass of: Disease Pathway
Definition: Obesity is associated with many adverse health effects, including an increased risk of diabetes and heart disease. The combined condition of obesity, diabetes, and heart disease is sometimes referred to as the metabolic syndrome. One of the factors that best correlates obesity with the rest of the metabolic syndrome is not overall body mass, but the distribution of adipose tissue in the abdominal region, visceral obesity. Glucocorticoids have been associated as a risk factor for the metabolic syndrome, but most obese individuals have normal levels of circulating corticosteroids. Active corticosteroids such as cortisol and corticosterone activate the glucocorticoid receptor, a nuclear hormone receptor and transcription factor. Obese individuals have elevated levels in adipose tissue of a key enzyme in glucocorticoid metabolism, 11beta hydroxysteroid dehydrogenase type 1 (11betaHSD-1). 11betaHSD-1 interconverts inactive corticosteroids and the active form. When present in cells, 11betaHSD-1 can convert inactive corticosteroids from the blood to create locally high concentrations in a tissue such as adipose tissue. When activated in adipose tissue, GR increases the level of visceral fat, induces insulin resistance and dyslipidemias that increase the risk of heart disease. The mechanisms by which GR might induce the various aspects of the metabolic syndrome are a key area of research. One of the genes activated by GR is lipoprotein lipase. When GR is activated in visceral adipose tissue, it will increase the expression of lipoprotein lipase (LPL). This enzyme hydrolyzes triglycerides in plasma, releasing free fatty acids into tissues, where they can be reassembled into triglycerides. In visceral adipose, this GR-driven overexpression of lipoprotein lipase will result in the increased deposits of visceral fat that are observed. Genes thought to be involved in insulin resistance also appear to be affected by altered 11betaHSD-1 corticosteroid metabolism in visceral fat. T…
MCID: MC00524295
PMOID: PMO:00014461
Subclass_of: Disease Pathway
Synonym: Visceral Fat Deposits and the Metabolic Syndrome
Tree Number: T4.3.17
database_cross_reference: NCI:C39268
database_cross_reference: NCI_BioC:C39268

MTA3 Pathway
type: Class
subclass of: Disease Pathway
Definition: Approximately 30% of breast carcinomas lack ER expression. Presumably, these breast cancers become estrogen independent through genetic alterations that bypass the requirement for ER-dependent stimulation of cell proliferation. As such, estrogen receptor is a key regulator of proliferation and differentiation in mammary epithelia and represents a crucial prognostic indicator and therapeutic target in breast cancer. Mechanistically, estrogen receptor induces changes in gene expression through direct gene activation of a number of genes (e.g., cathepsin D, HSP27, alpha-tubulin, glyceraldehyde-3-phosphatase, Pdzk1, Greb) and also through the biological functions of target loci. The product of human MTA3 has been identified as an estrogen-dependent component of the Mi-2/NuRD transcriptional corepressor in breast epithelial cells and demonstrates that MTA3 constitutes a key component of an estrogen-dependent pathway regulating growth and differentiation. The absence of estrogen receptor or of MTA3 leads to aberrant expression of the transcriptional repressor Snail, a master regulator of epithelial to mesenchymal transitions. Aberrant Snail expression results in loss of expression of the cell adhesion molecule E-cadherin, an event associated with changes in epithelial architecture and invasive growth. MTA3 is the mechanistic link between estrogen receptor status and invasive growth of breast cancers. (This definition may be outdated - see the DesignNote.)
MCID: MC00527045
PMOID: PMO:00014462
Subclass_of: Disease Pathway
Synonym: Downregulated of MTA-3 in ER-negative Breast Tumors
Tree Number: T4.3.18
database_cross_reference: NCI:C39158
database_cross_reference: NCI_BioC:C39158

Neurodegenerative Disorders Pathway
type: Class
subclass of: Disease Pathway
MCID: MC01394211
PMOID: PMO:00014463
Subclass_of: Disease Pathway
Synonym: Neurodegenerative Disorders
Tree Number: T4.3.19
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39737
database_cross_reference: NCI_KEGG:C39737

Alzheimer's Disease Pathway BioCarta
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: Cyclin-dependent kinase 5 (cdk5), a multi-functional kinase, and its neuron-specific activator p35 are required for neurite outgrowth and cortical lamination. Proteolytic cleavage of p35 produces p25, which accumulates in the brains of patients with Alzheimer's disease. Conversion of p35 to p25 causes prolonged activation and mislocalization of cdk5 and the hyperphosphorylates tau, leading to the formation of paired helical filaments and promotion of apoptosis. In cultured primary cortical neurons, excitotoxins, hypoxic stress and calcium influx induce the production of p25. In fresh brain lysates, addition of calcium can stimulate cleavage of p35 to p25. Specific inhibitors of calpain1 effectively inhibit the calcium-induced cleavage of p35. In vitro, calpain1 directly cleaves p35 to release a fragment with relative molecular mass 25,000. Application of the amyloid beta-peptide A beta induces the conversion of p35 to p25 in primary cortical neurons. Inhibition of cdk5 or calpain activity reduces cell death in A beta-treated cortical neurons. These observations indicate that cleavage of p35 to p25 by calpain may be involved in the pathogenesis of Alzheimer's disease. GSK3B also phosphorylates tau but does not induce hyperphosphorylation in response to calpain activating stimuli. Additionally, down-regulation or inhibition of PP2A increases the hyper-phosphorylation of tau. (This definition may be outdated - see the DesignNote.)
MCID: MC00523211
PMOID: PMO:00014464
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Deregulation of CDK5 in Alzheimers Disease
Tree Number: T4.3.19.1
database_cross_reference: NCI:C39177
database_cross_reference: NCI_BioC:C39177

Alzheimer's Disease Pathway KEGG
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specifically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
MCID: MC00528962
PMOID: PMO:00014465
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Alzheimer's Disease
Tree Number: T4.3.19.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38778
database_cross_reference: NCI_KEGG:C38778

Amyloid Beta-Peptide Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: Alzheimer's disease is associated with dense aggregations of proteins in the brain called amyloid plaques that contain beta-amyloid fragments as a primary component. If the development of amyloid plaques is responsible for neurodegeneration in Alzheimer's disease, reduction of beta-amyloid formation may prevent the development and progression of disease symptoms. Beta-amyloid fragments are derived from proteolytic processing of amyloid precursor protein (APP) in neurons, and the subsequent release of fragments into the extracellular space. APP in the ER is cleaved at residue 17 by alpha-secretase protease activity encoded by ADAM-10 and TACE. Beta-secretase activity, recently identified as BACE, cleaves in the N-terminus of the beta-amyloid fragment. Gamma-secretase cuts APP within the transmembrane domain at amino acids 40 and 42, releasing the beta-amyloid fragment containing residues 1-40/42 as well as shorter products such as p3 (residues 17-40/42) that requires alpha-secretase cleavage. The gamma-secretase activity requires the transmembrane protein Presenilin-1 that is itself cleaved into an N-terminal and C-terminal fragment that both are required for gamma-secretase activity. Mutations in presenilin-1 have been genetically associated with familial forms of Alzheimer's disease, further supporting the role of APP processing the development of the disease. Inhibition of the beta- or gamma-secretases may provide a mechanism to treat this disease. Other mechanisms may include altering degradation of beta-amyloid, and the use of vaccines against beta-amyloid to remove aggregates. (This definition may be outdated - see the DesignNote.)
MCID: MC00523066
PMOID: PMO:00014466
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Generation of amyloid b-peptide by PS1
Tree Number: T4.3.19.3
database_cross_reference: NCI:C38988
database_cross_reference: NCI_BioC:C38988

Amyotrophic Lateral Sclerosis Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord, leading to paralysis of voluntary muscles. Mutant superoxide dismutase 1 (SOD1), as seen in some familial amyotrophic lateral sclerosis (FALS) cases, may be toxic because it is unstable, forming aggregates in the motor neuron cytoplasm, axoplasm and mitochondria. Within mitochondria, mutant SOD1 may interfere with the anti-apoptotic function of Bcl-2, affect mitochondrial import by interfering with the translocation machinery (TOM/TIM), and generate toxic free radicals (ROS) via aberrant superoxide chemistry. These changes may then result in abnormal mitochondrial energy metabolism, Ca2+ handling, and release of pro-apoptotic factors. Reactive oxygen species (ROS), produced within mitochondria, inhibit the function of EAAT2, the main glial glutamate transporter protein, responsible for most of the reuptake of synaptically released glutamate. Glutamate excess causes neurotoxicity by increasing intracellular calcium, which enhances oxidative stress and mitochondrial damage. Mutant SOD1 can also trigger oxidative reactions by various means including by increasing levels of peroxynitrite, which can then cause damage through the formation of hydroxyl radicals or via nitration of tyrosine residues on proteins. Nitration may target neurofilament proteins, disrupting their phosphorylation and affecting axonal transport. Collectively, these mechanisms (or a combination thereof) are predicted to disturb cellular homeostasis (within glial and/or motor neurons), ultimately triggering motor neuron death.
MCID: MC01393717
PMOID: PMO:00014467
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Amyotrophic Lateral Sclerosis (ALS)
Tree Number: T4.3.19.4
database_cross_reference: NCI:C38782
database_cross_reference: NCI_KEGG:C38782

Huntington's Disease Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). HD is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (Htt). Mutant Htt (mHtt) has effects both in the cytoplasm and in the nucleus. In the cytoplasm, full-length mHtt can interfere with BDNF vesicular transport on microtubules. This mutant protein also may lead to abnormal endocytosis and secretion in neurons, because normal Htt form a complex with the proteins Hip1, clathrin and AP2 that are involved in endocytosis. In addition, mHtt affects Ca2+ signaling by sensitizing InsP3R1 to activation by InsP3, stimulating NR2B/NR1 NMDAR activity, and destabilizing mitochondrial Ca2+ handling. As a result, stimulation of glutamate receptors leads to supranormal Ca2+ responses in HD MSN and mitochondrial Ca2+ overload. The mHtt translocates to the nucleus, where it forms intranuclear inclusions, though they are not primarily responsible for toxicity. Nuclear toxicity is believed to be caused by interference with gene transcription, leading to loss of transcription of neuroprotective molecules such as BDNF. While mHtt binds to p53 and upregulates levels of nuclear p53 as well as p53 transcriptional activity. Augmented p53 mediates mitochondrial dysfunction.
MCID: MC01393852
PMOID: PMO:00014468
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Huntington's Disease
Tree Number: T4.3.19.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38825
database_cross_reference: NCI_KEGG:C38825

Inhibition of Huntington's Disease Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: Huntington's disease is a neurodegenerative condition caused by a dominant mutation in a gene encoding a protein now called huntingtin. Large polyglutamine repeats in the huntingtin protein are the genetic defect responsible for this condition, caused by expansion of a three-base pair repeat in the gene. Similar expansions of polyglutamine repeats are also found in other genes involved in neurodegenerative conditions. The polyglutamine repeat makes huntingtin protein insoluble and triggers the formation of protein aggregates. There are a few hypotheses for the connection between these aggregates and the neurodegeneration observed in Huntington's disease. One hypothesis is that mutant huntingtin moves into the nucleus and interferes with transcriptional activation involving the transcriptional coactivator CBP (CREB binding protein) and other coactivators. CBP interacts with transcriptional regulatory factors and with the basal transcriptional machinery to help regulate transcription. CBP is a large protein with multiple domains and in addition to interacting with several different transcription factors also has a histone acetylase enzyme activity. Mutant huntingtin binds to CBP, drawing it into insoluble protein aggregates. Mutant huntingtin also interacts directly with the acetyltransferase domain of CBP, blocking this activity. Activation of CBP acetyltransferase activity by transcriptional regulators results in the acetylation of histones in the promoter and enhancer regions of active genes, contributing to transcriptional activation by making these genes more accessible in chromatin. The lack of CBP in Huntington's affected neurons may lead to transcriptional repression of key genes that in turn leads to neurodegeneration. One potential treatment being tested is the treatment of Huntington's affected individuals with histone deacetylase inhibitors to restore normal acetylation levels and transcription. The repression of transcription may also be involved in other…
MCID: MC00524101
PMOID: PMO:00014469
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors
Tree Number: T4.3.19.6
database_cross_reference: NCI:C39110
database_cross_reference: NCI_BioC:C39110

Parkinson's Disease Pathway BioCarta
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examination of these neurons in diseased tissue has revealed the presence of Lewy bodies, dense aggregates that include the protein alpha-synuclein. A genetic basis for most cases of Parkinson's disease has not yet been identified, but mutations in alpha-synuclein have been associated with at least one rare form of the disease, and mutations in another protein, the parkin gene, are associated with another inherited form of Parkinson's disease. Parkin is found in Lewy bodies along with alpha-synuclein and the parkin protein is an enzyme, an E3 ubiquitin ligase. This ligase tags specific proteins in normal cells with ubiquitin, targeting them for destruction in the proteasome. One of the proteins that parkin normally targets for destruction is a specific O-glycosylated form of alpha-synuclein. Failure of parkin-mediated degradation of alpha-synuclein may be a key factor leading to the death of dopaminergic neurons. Another substrate of parkin is a GPCR-like protein called Pael-R that accumulates in the ER of affected cells and may cause neuronal cell death. The involvement of Parkin and alpha-synuclein mutations in genetic forms of Parkinson's suggests that failure of ubiquitination and protein degradation may be causative in other forms of Parkinson's. Questions remaining include the cause of the lack of effective ubiquitination in individuals lacking obvious genetic defects in this pathway and how to use this knowledge of ubiquitination and protein degradation in Parkinson's disease to identify therapeutic strategies. (This definition may be outdated - see the DesignNote.)
MCID: MC00523212
PMOID: PMO:00014470
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease
Tree Number: T4.3.19.7
database_cross_reference: NCI:C39276
database_cross_reference: NCI_BioC:C39276

Parkinson's Disease Pathway KEGG
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL1 (ubiquitin carboxy-terminal hydrolase L1), parkin, DJ1 (a parkin-associated protein involved with oxidative stress), and PINK1 (a putative serine threonine kinase) are known to cause early-onset PD. Mutations or altered expression of these proteins contributes to PD pathogenesis through common mechanisms that result in proteasome dysfunction, mitochondrial impairment, and oxidative stress. Point mutations in alpha-synuclein and the recently described functional duplication of alpha-synuclein lead to excessive intracellular accumulation and protofibril formation. Decrease in the amount of soluble alpha-synuclein tends to increase free cytoplasmic dopamine and the formation of reactive oxygen species (ROS). Indeed, formation of protofibrils or aggregates and Lewy bodies (LBs) diminishes the availability of the physiological forms of alpha-synuclein, favoring an increase in TH (tyrosine hydroxylase) and DAT (dopamine transporter), but diminishes formation of vesicles and neuronal plasticity. Modification of parkin and UCHL1 are associated with the ubiquitin-proteasome system pathway and may increase proteotoxic stress. Mutations in parkin, DJ1, and PINK1 may alter mitochondrial activity, potentially impairing proteasomal function. Environmental toxins such as N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone can cause mitochondrial dysfunction and oxidative stress.
MCID: MC01393964
PMOID: PMO:00014471
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Parkinson's Disease
Synonym: Parkinson's Disease Pathway
Tree Number: T4.3.19.8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38845
database_cross_reference: NCI_KEGG:C38845

Prion Disease Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
MCID: MC00922504
PMOID: PMO:00014472
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Prion Disease
Tree Number: T4.3.19.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38853
database_cross_reference: NCI_KEGG:C38853

Prion Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
Definition: Transmissible spongiform encephalopathy (TSE) is thought to result from the structural conversion of cellular prion protein, PrP(C), into a misfolded oligomeric form, PrP(Sc). PrP is a cell membrane GPI anchored glycoprotein that is expressed in most tissues and in high levels in the nervous system. Some likely cellular functions of PrP are (1) cell protection against oxidative stress, (2) induction of neuronal cell adhesion, neurite extension and maintenance, and (3) neuroprotective signaling through a cAMP/PKA-dependent pathway. (This definition may be outdated - see the DesignNote.)
MCID: MC00524981
PMOID: PMO:00014473
Subclass_of: Neurodegenerative Disorders Pathway
Tree Number: T4.3.19.10
database_cross_reference: NCI:C39201
database_cross_reference: NCI_BioC:C39201

NFAT Pathway
type: Class
subclass of: Disease Pathway
Definition: Hypertrophy associated with both hypertension and obstruction to ventricular outflow leads to pathologic cardiac growth and it is associated with increase morbidity and mortality. Symptomatic ventricular disease takes a growing toll on the health of nations. As other cardiovascular diseases such as stroke and myocardial infarction are in decline as causes of mortality, the heart failure problem becomes increasingly urgent. Congenital heart defects occur in 1% of live births and fetal heart malformations are implicated in many pregnancies that end in still-birth or spontaneous abortion. The current paradigm suggests that the heart adapts to excess of hemodynamic loading by compensatory hypertrophy, which under condition of persistent stress, over time evolves into dysfunction and myocardial failure. There is considerable evidence that direct effects of increased mechanical stress are sensed within the ventricular wall and that signal is critical for the generation of growth responses. Despite compelling statistics we still do not understand biochemically why heart defects are so prevalent. A single transcriptional regulator initially associated with the activation of the T-cells (NFATc4) has been shown to link genetic and environmental causes of one class of congenital heart disorders, birth defects involving valve and septum formation. Within the endocardium, specific inductive events appear to activate NF-ATc: it is localized to the nucleus only in endocardial cells that are adjacent to the interface with the cardiac jelly and myocardium, which are thought to give the inductive stimulus to the valve primordia. Treatment with FK506, a specific calcineurin inhibitor, prevents nuclear localization of NF-ATc4. Activated CaMK stimulates calcineurin, which than acts through NF-ATc4 in association with GATA4, to induce hypertrophy. A model for the proposed role of calreticulin in the regulation of cardiac development requires a myogenic signal from extracellular space to …
MCID: MC00524574
PMOID: PMO:00014474
Subclass_of: Disease Pathway
Synonym: NFAT and Hypertrophy of the heart (Transcription in the broken heart)
Tree Number: T4.3.20
database_cross_reference: NCI:C39162
database_cross_reference: NCI_BioC:C39162

Primary Immunodeficiency Pathway
type: Class
subclass of: Disease Pathway
Definition: Primary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells such as phagocytes and natural killer (NK) cells. These disorders of the immune system cause increased susceptibility to infection, autoimmune disease, and malignancy. Most of PIs are due to genetic defects that affect cell maturation or function at different levels during hematopoiesis. Disruption of the cellular immunity is observed in patients with defects in T cells or both T and B cells. These cellular immunodeficiencies comprise 20% of all PIs. Disorders of humoral immunity affect B-cell differentiation and antibody production. They account for 70% of all PIs.
MCID: MC01393837
PMOID: PMO:00014475
Subclass_of: Disease Pathway
Synonym: Primary immunodeficiency
Tree Number: T4.3.21
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91500
database_cross_reference: NCI_KEGG:C91500

Skeletal Muscle Hypertrophy Pathway
type: Class
subclass of: Disease Pathway
Definition: Skeletal muscle atrophies with disuse while with increased use and increased load skeletal muscle exhibits hypertrophy, with an increase in the size of existing muscle fibers. One signaling pathway involved in regulating skeletal muscle atrophy and hypertrophy is the AKT/mTOR pathway. The mTOR pathway activity increases in response to muscle activity during hypertrophy and decreases in activity during atrophy. Blocking this pathway genetically or with the mTOR inhibitor rapamycin blocks hypertrophy and genetic activation of the pathway induces hypertrophy. One agent that promotes muscle hypertrophy is the growth factor IGF-1. IGF-1 activates AKT, GSK-3 beta, and mTOR to promote hypertrophy. In contrast, the calcineurin pathway is not involved in hypertrophy and is down-regulated by agents such as IGF-1 that promote hypertrophy. Calcineurin may modulate other aspects of muscle function such as the development of slow muscle fibers through transcriptional regulation. These pathways lead to regulation of protein translation, with increased translation apparently acting as a key regulatory point in skeletal muscle hypertrophy. Agents such as IGF-1 that stimulate skeletal muscle hypertrophy may provide treatments for muscle atrophy and wasting. (This definition may be outdated - see the DesignNote.)
MCID: MC00527608
PMOID: PMO:00014476
Subclass_of: Disease Pathway
Synonym: Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
Tree Number: T4.3.22
database_cross_reference: NCI:C39113
database_cross_reference: NCI_BioC:C39113

Systemic Lupus Erythematosus Pathway
type: Class
subclass of: Disease Pathway
Definition: Systemic lupus erythematosus (SLE) is characterized by circulating IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components. Immune complexes comprising autoantibody and self-antigen is deposited particularly in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc-gamma-R-mediated neutrophil and macrophage activation. Activation of complement leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.
MCID: MC01393827
PMOID: PMO:00014477
Subclass_of: Disease Pathway
Synonym: SLE Pathway
Synonym: Systemic lupus erythematosus
Tree Number: T4.3.23
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91508
database_cross_reference: NCI_KEGG:C91508

Type I Diabetes Mellitus Pathway
type: Class
subclass of: Disease Pathway
Definition: Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).
MCID: MC01393768
PMOID: PMO:00014478
Subclass_of: Disease Pathway
Synonym: Type I diabetes mellitus
Tree Number: T4.3.24
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91529
database_cross_reference: NCI_KEGG:C91529

Type II Diabetes Mellitus Pathway
type: Class
subclass of: Disease Pathway
Definition: Insulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process.
MCID: MC01393694
PMOID: PMO:00014479
Subclass_of: Disease Pathway
Synonym: Type II diabetes mellitus
Tree Number: T4.3.25
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91490
database_cross_reference: NCI_KEGG:C91490

DNA Repair Pathway
type: Class
subclass of: Biochemical Pathway
Definition: A sequence of biological or biochemical events that play a role in DNA repair.
MCID: MC01394218
PMOID: PMO:00014480
Subclass_of: Biochemical Pathway
Tree Number: T4.4
database_cross_reference: NCI:C39705

BARD1 Pathway
type: Class
subclass of: DNA Repair Pathway
Definition: BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and the resulting complex functions as an E3 ubiquitin ligase that catalyzes the synthesis of polyubiquitin chains. UbcH5c and UbcH7 also interact with the BRCA1/BARD1 complex with similar affinity (not shown on this figure). Although the in vivo substrate(s) is not yet known, BRCA1 has been observed to undergo autoubiquitination and is capable of monoubiquitinating histones 2A and 2AX in vitro. (This definition may be outdated - see the DesignNote.)
MCID: MC00526027
PMOID: PMO:00014481
Subclass_of: DNA Repair Pathway
Synonym: BRCA1-dependent Ub-ligase activity
Tree Number: T4.4.1
database_cross_reference: NCI:C38999
database_cross_reference: NCI_BioC:C38999

BARD1 Signaling Pathway
type: Class
subclass of: DNA Repair Pathway
MCID: MC01394194
PMOID: PMO:00014482
Subclass_of: DNA Repair Pathway
Synonym: BARD1 signaling events
Tree Number: T4.4.2
database_cross_reference: NCI:C91550
database_cross_reference: NCI_PID:C91550

Base Excision Repair Pathway
type: Class
subclass of: DNA Repair Pathway
Definition: Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
MCID: MC01394159
PMOID: PMO:00014483
Subclass_of: DNA Repair Pathway
Synonym: Base excision repair
Tree Number: T4.4.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91457
database_cross_reference: NCI_KEGG:C91457

Homologous Recombination Pathway
type: Class
subclass of: DNA Repair Pathway
Definition: Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
MCID: MC01394258
PMOID: PMO:00014484
Subclass_of: DNA Repair Pathway
Synonym: Homologous recombination
Tree Number: T4.4.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91483
database_cross_reference: NCI_KEGG:C91483

Mismatch Repair Pathway
type: Class
subclass of: DNA Repair Pathway
Definition: DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
MCID: MC01394363
PMOID: PMO:00014485
Subclass_of: DNA Repair Pathway
Synonym: DNA Mismatch Repair Pathway
Synonym: Mismatch repair
Tree Number: T4.4.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91471
database_cross_reference: NCI_KEGG:C91471

Non-Homologous End-Joining Pathway
type: Class
subclass of: DNA Repair Pathway
Definition: Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
MCID: MC01394110
PMOID: PMO:00014486
Subclass_of: DNA Repair Pathway
Synonym: NHEJ Pathway
Synonym: Non-homologous end-joining
Tree Number: T4.4.6
database_cross_reference: NCI:C91444
database_cross_reference: NCI_KEGG:C91444

Nucleotide Excision Repair Pathway
type: Class
subclass of: DNA Repair Pathway
Definition: Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
MCID: MC01394165
PMOID: PMO:00014487
Subclass_of: DNA Repair Pathway
Synonym: Nucleotide excision repair
Tree Number: T4.4.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91447
database_cross_reference: NCI_KEGG:C91447

Drug Pathway
type: Class
subclass of: Biochemical Pathway
Definition: An elaboration of a sequence of physiological events that are elicited by the administration of a drug.
MCID: MC01393811
PMOID: PMO:00014488
Subclass_of: Biochemical Pathway
Tree Number: T4.5
database_cross_reference: NCI:C91821

Acetaminophen Pathway
type: Class
subclass of: Drug Pathway
Definition: Acetaminophen is one of the world's most commonly used drugs, used for the treatment of pain and fever. Like other NSAIDs (non-steroidal anti-inflammatory drugs), acetaminophen has a unique activity profile based in part on its action at its molecular targets, the cyclooxygenase enzymes that produce prostaglandins responsible for pain, fever and inflammation. Until very recently, only two Cox enzymes, Cox-1 and Cox-2, were known to be targets of NSAIDS. Cox-1 is expressed in a constitutive manner throughout most tissues, and plays an essential role in maintaining the integrity of the stomach mucosal lining. Cox-2 is an inducible enzyme whose expression is induced by inflammation. NSAIDS selective for Cox-2 have been developed to avoid the development of ulcers by some non-selective NSAIDs, including aspirin. While these two isoforms were sufficient to account for most NSAIDs pharmacology, the actions of acetaminophen remained hard to explain on the basis of inhibiting Cox-1 and Cox-2 alone, such as its efficacy at reducing pain and fever but lack of anti-inflammatory effects. A novel Cox enzyme isoform encoded by the Cox-1 gene, Cox-3, contains an additional 30-34 amino acids and is expressed selectively in the brain. This insertion alters the pharmacology of the Cox enzyme, making Cox-3 sensitive to selective inhibition by acetaminophen and other drugs that reduce pain and fever but have weak anti-inflammatory activity, explaining the pharmacology of these drugs. Another characteristic of acetaminophen is its liver toxicity when taken at high doses. The target of this toxicity has also been recently been revealed. The nuclear receptor CAR is activated by many different exogenous compounds, including acetaminophen, inducing expression of three cytochrome P450 enzymes that transform acetaminophen into NAPQI, a reactive and toxic metabolite. Blocking CAR activation with an antagonist protects against acetaminophen liver toxicity, suggesting a strategy to treat acetami…
MCID: MC00523002
PMOID: PMO:00014489
Subclass_of: Drug Pathway
Synonym: Mechanism of Acetaminophen Activity and Toxicity
Tree Number: T4.5.1
database_cross_reference: NCI:C38970
database_cross_reference: NCI_BioC:C38970

Aspirin Inhibition of Platelet Activation Pathway
type: Class
subclass of: Drug Pathway
Definition: Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotting. The protease-activated receptors PAR1 and PAR4 are cleaved by the protease thrombin, releasing a tethered peptide ligand that activates the receptor and triggers intracellular calcium release. Platelets from mice lacking the PAR4 gene are not activated by thrombin and are impaired in clotting, supporting the importance of thrombin signaling through PAR4 in clotting. Human platelets express both PAR1 and PAR4, with PAR1 playing a more dominant role in clotting in humans. Calcium release induced by PARs activates PKC, modulating integrin alpha IIB beta 3 (glycoprotein IIb/IIIa) and opening integrin ligand binding sites to contribute to platelet aggregation. Intracellular calcium increases induced by thrombin activate phospholipase A2, liberating arachidonic acid, the first step in prostaglandin and thromboxane biosynthesis. Ras/Map kinase activation by the PAR receptors also activates phospholipase A2. The activation of PAR-induced platelet aggregation is inhibited by aspirin, indicating that thromboxane production induced by PAR signaling contributes to platelet activation. Arachidonic acid is converted to the prostaglandin PGG2 by the enzyme Cox-1 in platelets, and Cox-1 is inhibited by aspirin, reducing thromboxane A2 production by platelets. Thromboxane is a potent vasoconstrictor and platelet activator, so inhibition of Cox-1 in platelets by aspirin may explain some of the cardioprotective actions of aspirin. (This definition may be outdated - see the DesignNote.)
MCID: MC01393661
PMOID: PMO:00014490
Subclass_of: Drug Pathway
Synonym: Aspirin Blocks Signaling Pathway Involved in Platelet Activation
Tree Number: T4.5.2
database_cross_reference: NCI:C39235
database_cross_reference: NCI_BioC:C39235

Corticosteroid Cardioprotection Pathway
type: Class
subclass of: Drug Pathway
Definition: Myocardial infarction damages heart tissue both during the initial ischemia and the subsequent reperfusion of tissues with oxygen. Corticosteroids can protect cardiac tissue from damage following a heart attack, but the mechanisms by which corticosteroids are cardioprotective have not been clear and negative side effects such as reduced wound healing may result from their use. Corticosteroids exert a variety of actions through binding to the glucocorticoid receptor (GR), a member of the steroid hormone receptor gene family. GR acts as a ligand-dependent transcription factor, but some of the cardioprotective effects mediated by GR-bound corticosteroids are non-transcriptional in nature. Glucocorticoids are commonly used as anti-inflammatory drugs in a variety of conditions, and some of their effects in the heart result from inhibition of the inflammatory response of heart tissue to ischemia and reperfusion. NF-kB is a transcription factor involved in signaling by inflammatory factors such as TNF, and is repressed by glucocorticoids. Annexin-1 is a calcium-dependent phospholipid binding protein whose expression is induced by corticosteroids and inhibits the infiltration of neutrophils into tissue, blocking reperfusion-induced inflammatory heart damage. A non-transcriptional cardioprotective effect of glucocorticoids is activation of NO production by endothelial nitric oxide synthase (eNOS). Glucocorticoids activate eNOS through activation of PI3 kinase and AKT and increased NO produced by eNOS can diffuse into surrounding tissues to prevent clotting and cause vasodilation. The beta-2 adrenergic receptor can also activate PI3 kinase and may synergize with glucocorticoids in this pathway. The atrial natriuretic factor (ANF) is a peptide secreted by the atrial wall in response to increased atrial pressure such as occurs during cardiac failure and to be decreased by myocardial infarction. Glucocorticoids increase the secretion of ANF by acting at the transcriptional level…
MCID: MC00523416
PMOID: PMO:00014491
Subclass_of: Drug Pathway
Synonym: Corticosteroids and cardioprotection
Tree Number: T4.5.3
database_cross_reference: NCI:C39091
database_cross_reference: NCI_BioC:C39091

Flumazenil Cardioprotection Pathway
type: Class
subclass of: Drug Pathway
Definition: Flumazenil is a benzodiazepine receptor antagonist. It is used clinically to reverse the effects of benzodiazepines in conscious sedation, general anesthesia, and management of suspected benzodiazepine overdose. Kochs and colleagues reported that flumazenil might be beneficial in protecting against cerebral ischemia. Rapid administration of flumazenil produced minimal coronary and left ventricular hemodynamic responses. Thus this agent may be a potential candidate for clinical application in patients with ischemic heart diseases if it can mimic preconditioning to protect the heart. The study by Zhang and Yao indicates that flumazenil mimics preconditioning in cardiomyocytes via the generation of H2O2 as the reactive oxygen species (ROS). H2O2 opens mitochondrial KATP channels and inhibits GABA receptors via protein kinase C-epsilon in cardiomyocytes inducing ischemic preconditioning. This signal transduction and preconditioning protects ischemic cardiomyocytes. Zhang et al. indicate that the potential beneficial effects of Allitridum appear to mimic the same effects as flumazenil, to precondition cardiomyocytes, via the stimulation of PKC. Allitridum is an extract of garlic taken as a medicine in China for over 3000 years. (This definition may be outdated - see the DesignNote.)
MCID: MC00526500
PMOID: PMO:00014492
Subclass_of: Drug Pathway
Synonym: Cardiac Protection Against ROS
Tree Number: T4.5.4
database_cross_reference: NCI:C39081
database_cross_reference: NCI_BioC:C39081

FosB Drug-induction Pathway
type: Class
subclass of: Drug Pathway
Definition: Drug addiction is associated with long-term behavioral changes, suggesting a long-lived transcriptional regulator that responds to chronic drug exposure might cause long-term changes in neuronal function. Neurons in the nucleus accumbens and striatum are involved in addiction and have altered synaptic properties in response to chronic drug exposure. Along with JunD, delta-FosB is a component of an AP-1 transcription factor that accumulates in these key brain regions after chronic exposure to drugs of abuse, including morphine, amphetamine, alcohol, and cocaine. Delta-FosB is an unusually stable splice variant of the immediate early FosB gene, accumulating and persisting in the brain long after drug is removed. One component of FosB stability is post-translational modification through phosphorylation. Genetically modified mice that selectively overexpress this protein in neurons have increased sensitivity to cocaine and increased apparent reward response to drug administration, as expected in addiction, supporting the role of delta-FosB in addiction. The target genes regulated by delta-FosB include the GluR2 subunit of the AMPA glutamate receptor. Increased expression of GluR2 modifies the conductance and calcium flux of neurons, and may be responsible for increased reward responses to drug. Another target of delta-FosB is the dynorphin gene, the ligand for the kappa opioid receptor, further altering reward responses to drugs. The cell cycle checkpoint kinase cdk2 is activated by delta-FosB and acts on Darpp-32 to alter dopaminergic signaling. Although delta-FosB is very stable, it does degrade after several weeks, while the behavioral changes of drug addiction persist much longer after drug exposure ends. Changes in chromatin structure or changes in synaptic structure induced initially by delta-FosB may persist long after delta-FosB is no longer present, allowing behavioral changes to persist. (This definition may be outdated - see the DesignNote.)
MCID: MC00526546
PMOID: PMO:00014493
Subclass_of: Drug Pathway
Synonym: FOSB gene expression and drug abuse
Tree Number: T4.5.5
database_cross_reference: NCI:C39083
database_cross_reference: NCI_BioC:C39083

Inhibition of Cellular Proliferation by Gleevec Pathway
type: Class
subclass of: Drug Pathway
Definition: The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia. While traditional cytotoxic cancer treatments such as chemotherapy or radiation therapy kill all dividing cells, Gleevec acts on a molecular target by a mechanism that is more specific to cancer cells. Traditional cytotoxic cancer agents have serious side effects such as nausea, weight loss, hair loss and severe fatigue that result from their lack of specificity in killing cells. Gleevec was designed as an inhibitor of a specific receptor associated with CML, and so produces less severe side effects than other cancer agents. CML is associated in most cases with a specific chromosomal defect, a translocation between chromosomes 9 and 22 that creates the Philadelphia chromosome. This translocation creates the abnormal bcr-abl protein, a fusion of the Abl gene with another gene called Bcr. The kinase activity of Abl in the bcr-abl fusion is activated and unregulated, driving the uncontrolled cell growth observed in CML. White blood cells containing the bcr-abl mutation become able to proliferate in the absence of growth factors they normally require. Gleevec inhibits Abl kinase activity, helping to reverse uncontrolled cell growth. Gleevec also inhibits the PDGF tyrosine kinase and the c-kit tyrosine kinase. There are a variety of cellular substrates of the bcr-abl kinase that may be involved in cellular transformation. Some of the downstream factors in bcr-abl signaling include PI3 kinase/AKT and STAT transcription factors. The activation of bcr-abl also represses apoptosis through induction of anti-apoptosis factors such as Bad, allowing transformed cells to divide. JAK2 kinase activity appears to be one target of bcr-abl. Grb-2 phosphorylation by bcr-abl may play a role in down-regulation of tyrosine kinase signaling. STAT5 may be involved in the failure of apoptosis in bcr-abl cells. In addition to supporting the idea tha…
MCID: MC00524100
PMOID: PMO:00014494
Subclass_of: Drug Pathway
Synonym: Inhibition of Cellular Proliferation by Gleevec
Tree Number: T4.5.6
database_cross_reference: NCI:C39094
database_cross_reference: NCI_BioC:C39094

Genetic Information Processing Pathway
type: Class
subclass of: Biochemical Pathway
Definition: A sequence of biological or biochemical events that are involved in the conversion of genetic information into physiologically active molecules, such as functional RNA and proteins.
MCID: MC00526683
PMOID: PMO:00014495
Subclass_of: Biochemical Pathway
Synonym: Genetic Information Processing
Tree Number: T4.6
database_cross_reference: NCI:C39736
database_cross_reference: NCI_KEGG:C39736

Aminoacyl-tRNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
PMOID: PMO:00014496
Subclass_of: Genetic Information Processing Pathway
Tree Number: T4.6.1

DNA Replication Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.
MCID: MC01394166
PMOID: PMO:00014497
Subclass_of: Genetic Information Processing Pathway
Synonym: DNA replication
Tree Number: T4.6.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91448
database_cross_reference: NCI_KEGG:C91448

Double Stranded RNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: About 8% of human genes have been estimated to carry out transcription from both DNA strands, resulting in significant level of endogenous antisense RNA. In the cytoplasm the antisense RNA leads to formation of long dsRNA, which activates the interferon and RNA-dependent protein kinase antiviral pathway. Most endogenous antisense RNA is made in the nucleus and two responses have been suggested for the nuclear dsRNA. First, the dsRNA may be processed by enzymes of the family of adenosine deaminases that act on RNA (ADAR). The deaminated dsRNAs contain various levels of inosines. dsRNA containing high level of inosines are tightly bound by a protein complex that results in their nuclear retention. dsRNA containing low level of inosines may be able to exit the nucleus. Second, the nuclear dsRNA can lead to gene silencing and heterochromatin formation. (This definition may be outdated - see the DesignNote.)
MCID: MC00525078
PMOID: PMO:00014498
Subclass_of: Genetic Information Processing Pathway
Synonym: Antisense Pathway
Synonym: RNA Interference Pathway
Synonym: dsRNA Biosynthesis Pathway
Tree Number: T4.6.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38987
database_cross_reference: NCI_BioC:C38987

Gene Silencing Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: Packaging of DNA into chromatin allows the cell to store its genetic information efficiently and has an important role in regulating gene expression. Recent studies have revealed that chromatin structure can be altered by covalent modification of nucleosomes, in particular acetylation and methylation of the core histone tails. Histone hyperacetylation usually characterizes active chromatin, while histone deacetylation correlates with repressed transcription. The Polycomb group (PcG) proteins are constituents of evolutionary highly conserved molecular pathways regulating cell fate in several tissues through diverse mechanisms, including 1) regulation of self-renewal/proliferation, 2) regulation of senescence/immortalization, 3) interaction with the initiation transcription machinery, 4) interaction with chromatin-condensation proteins, 5) modification of histones, 6) inactivation of paternal X chromosome, and 7) regulation of cell death. The PcG proteins form multimeric protein complexes, PRC1 and PRC2 which are involved in the heritable, stable repression of genes through modification of chromatin structure. The EED-EZH2 complex (PRC 2 complex) acts early in development to set the stage for the long term repressive PRC1 complex. The PRC2 complex is probably tethered to promoters of affected genes through the interaction with specific DNA binding factors, such as YY1, a zinc finger transcription factor that acts as both a positive and negative regulator of transcription of cellular and viral genes. The EED-EZH2 proteins interact with histone deacetylase core complex consisting of the histone deacetylases HDAC1 and HDAC2 and the histone binding proteins RbAp48 and RbAp46. Histone deacetylation is probably a prerequisite for subsequent methylation, as histone tails cannot be acetylated and methylated in the same time. The PRC complex specifically methylates nucleosomal histone H3 at lysine 27, providing an epigenetic mark for binding of PRC1 complex. The histone methyl…
MCID: MC00526678
PMOID: PMO:00014499
Subclass_of: Genetic Information Processing Pathway
Synonym: The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails
Tree Number: T4.6.4
database_cross_reference: NCI:C39200
database_cross_reference: NCI_BioC:C39200

Internal Ribosome Entry Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: Control of translation is one of the major regulatory events in eukaryotic gene expression. Internal ribosome entry sites (IRES) were first discovered in picornavirus RNAs but it is now clear that IRESs are also present in the 5' untranslated region of many eukaryotic genes including those encoding growth factors (e.g., VEGF, FGF2 and PDGF), genes whose protein products are associated with apoptosis (e.g., Apaf-1, IXAP), transcription factors (e.g., c- myc), and the potassium channel Kv1.4. IRES allows the ribosomes to be recruited to an initiator AUG, which is some distance from the 5' end of the message RNA to bypass the Kozak scanning mechanism. In the Kozak scanning model, the 40S ribosomal subunit bearing Met-tRNAmet and initiation factors, binds near the capped 5' end of the mRNA and travels along the mRNA until it comes to the first AUG. IRES-dependent initiation of protein synthesis occurs during apoptosis or some viral infection (e.g., picornavirus). A component of the cap-binding complex eIF-4F, translation initiation factor eIF-4G, is cleaved (by caspases or viral protein 2A) to give a modified form of cap-binding complex that is cap-independent. (This definition may be outdated - see the DesignNote.)
MCID: MC01394109
PMOID: PMO:00014500
Subclass_of: Genetic Information Processing Pathway
Synonym: Internal Ribosome entry pathway
Tree Number: T4.6.5
database_cross_reference: NCI:C39134
database_cross_reference: NCI_BioC:C39134

mRNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
MCID: MC01394062
PMOID: PMO:00014501
Subclass_of: Genetic Information Processing Pathway
Synonym: mRNA Biosynthesis (Eukaryotes)
Tree Number: T4.6.6
database_cross_reference: NCI:C38837
database_cross_reference: NCI_KEGG:C38837

Basal Transcription Factor Assembly Pathway
type: Class
subclass of: mRNA Biosynthesis Pathway
MCID: MC01394226
PMOID: PMO:00014502
Subclass_of: mRNA Biosynthesis Pathway
Synonym: Basal transcription factors
Tree Number: T4.6.6.1
database_cross_reference: NCI:C91428
database_cross_reference: NCI_KEGG:C91428

RNA Polymerase Assembly Pathway
type: Class
subclass of: mRNA Biosynthesis Pathway
MCID: MC01394225
PMOID: PMO:00014503
Subclass_of: mRNA Biosynthesis Pathway
Synonym: RNA polymerase
Tree Number: T4.6.6.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91427
database_cross_reference: NCI_KEGG:C91427

Spliceosome Pathway
type: Class
subclass of: mRNA Biosynthesis Pathway
Definition: After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
MCID: MC01394143
PMOID: PMO:00014504
Subclass_of: mRNA Biosynthesis Pathway
Synonym: Spliceosome
Tree Number: T4.6.6.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91451
database_cross_reference: NCI_KEGG:C91451

Polyadenylation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: Gene expression requires the coordination and integration of multiple processes, including transcription, splicing, polyadenylation, nucleocytoplasmic export, and translation of mRNAs. Posttranscriptional addition of poly (A) to the 3' end of mRNA is an important process conserved from bacteria to humans. In eukaryotes, polyadenylation is essential for the stability of many mRNAs and also influences the efficiency of translation. Most histone-mRNAs and all snRNAs (except U6), however are not polyadenylated. The mature mRNA moves to the nuclear surface and is exported through nuclear pores. (This definition may be outdated - see the DesignNote.)
MCID: MC00391966
PMOID: PMO:00014505
Subclass_of: Genetic Information Processing Pathway
Synonym: Polyadenylation of mRNA
Synonym: mRNA polyadenylation
Synonym: mRNA polyadenylylation
Tree Number: T4.6.7
database_cross_reference: GO:GO:0006378
database_cross_reference: NCI:C39034
database_cross_reference: NCI_BioC:C39034

Protein Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
MCID: MC01394021
PMOID: PMO:00014506
Subclass_of: Genetic Information Processing Pathway
Synonym: Protein Biosynthesis (Eukaryotes)
Tree Number: T4.6.8
database_cross_reference: NCI:C38856
database_cross_reference: NCI_KEGG:C38856

Ribosome Assembly Pathway
type: Class
subclass of: Protein Biosynthesis Pathway
MCID: MC01394222
PMOID: PMO:00014507
Subclass_of: Protein Biosynthesis Pathway
Synonym: Ribosome
Tree Number: T4.6.8.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91426
database_cross_reference: NCI_KEGG:C91426

Protein Translation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: The scanning translation initiation model suggests that 40S ribosomal subunit preloaded with factors bind to the 5' end of the mRNA near the cap. The 48S subunit moves along the mRNA until it finds the initiation triplet and in complex with tRNA and 60S subunit forms the first peptide bond. Translation control is mostly regulated at the protein initiation step through translation initiation factors such as eIF2 or eIF4. (This definition may be outdated - see the DesignNote.)
MCID: MC00525035
PMOID: PMO:00014508
Subclass_of: Genetic Information Processing Pathway
Synonym: Eukaryotic protein translation
Tree Number: T4.6.9
database_cross_reference: NCI:C39063
database_cross_reference: NCI_BioC:C39063

RNA Degradation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
MCID: MC01393872
PMOID: PMO:00014509
Subclass_of: Genetic Information Processing Pathway
Synonym: RNA degradation
Tree Number: T4.6.10
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91512
database_cross_reference: NCI_KEGG:C91512

RNA Polymerase III Transcription Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: Unlike the RNA polymerase II that transcribes a large variety of genes that encode proteins, RNA polymerase III transcribes only a limited number of genes (i.e., 5S rRNA, tRNA, 7SL RNA, U6 snRNA, and a few other small stable RNAs); however, the transcriptional activities of RNA pol III along with pol I account for 80% of total RNA synthesis. The A and B block sequences found in most pol III promoters are recognized by a multisubunit complex, TFIIIC. The binding of TFIIIC recruits TFIIIB, a complex of polypeptides (in human, TATA-binding protein (TBP), TFIIB-related factor (BRF), and one or more unidentified protein). Once TFIIIB is brought to the general location by TFIIIC and optimally positioned by TBP, the transcription initiates about 30bp downstream. The transcription process requires the melting of dsDNA and participation of TFIIIB. Unlike pol I and II, pol III termination occurs efficiently at four or more T residues without other protein factors. La protein can stimulate the release of RNA and pol III transcription; however, deletion of La has no apparent effect on pol III activity. (This definition may be outdated - see the DesignNote.)
MCID: MC01393999
PMOID: PMO:00014510
Subclass_of: Genetic Information Processing Pathway
Synonym: RNA polymerase III transcription
Tree Number: T4.6.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39225
database_cross_reference: NCI_BioC:C39225

rRNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
MCID: MC01394072
PMOID: PMO:00014511
Subclass_of: Genetic Information Processing Pathway
Synonym: rRNA Biosynthesis (Eukaryotes)
Tree Number: T4.6.12
database_cross_reference: NCI:C38863
database_cross_reference: NCI_KEGG:C38863

Spliceosome Assembly Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: The assembly of the spliceosome is a dynamic process that involves both small ribonucleoprotein particles (snRNPs), and non-snRNP proteins. The complete spliceosome consists of 5 snRNPs (U1, U2, U4, U5, and U6) and 50-100 non-snRNP factors. The snRNPs themselves contain a snRNA and a number of different proteins. These proteins can be subdivided into two classes, those specific to the individual snRNP, and those common to all snRNPs. The later group consists of eight polypeptides; B, B', D1, D2, D3, E, F, and G, which bind together in a tight association, and are referred to as the sm proteins. While some of the particle-specific proteins have been well studied, i.e.U1-70K or U1-A, many have only been identified by their molecular weight and have yet to be cloned. These snRNP components are recruited to the pre-mRNA in an ordered manner, and begin with the recognition of exon-intron boundaries. The 5' end of the U1 snRNP recognizes the 5' splice site of the pre-mRNA. This interaction is mediated through conventional base pairing. Subsequently snRNP U1 recognizes and binds to the conserved branch point adenosine site. This step in the splicing cycle is called the commitment complex (CC) and is defined as a point where the formation of a stable splicing complex commits the spliceosome to assemble. Binding of the U1 snRNP encourages binding of U2 snRNP, and is helped by U2AF protein. SR proteins such as ASF/SF2 and SC35, or other intron bridging proteins, mediate the interaction between U1, U2 and U2AF. Binding of these factors facilitate recognition of the 3' splice site, and this whole complex is called the E (Early) complex. Spliceosomal A Complex is formed following recruitment of U2 snRNP to the branch point sequence. Meanwhile, snRNPs U4/U6 and U5 have formed a functional tri-snRNP complex. The association of the tri-snRNP U4/U6-U5 with the pre-spliceosome creates the B complex. Several RNA:RNA interactions occur following this point, including the disassociation…
MCID: MC00391975
PMOID: PMO:00014512
Subclass_of: Genetic Information Processing Pathway
Synonym: Spliceosome Assembly
Synonym: spliceosome assembly
Tree Number: T4.6.13
database_cross_reference: GO:GO:0000245
database_cross_reference: NCI:C39233
database_cross_reference: NCI_BioC:C39233

Splicing Regulation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: While transcriptional regulation is often viewed as the most prevalent way extracellular signals act to regulate gene expression, post-transcriptional regulation of splicing, RNA stability, and translation are also regulated by extracellular signals. Sam68, a member of a family of RNA-binding proteins called STAR proteins, mediates alternative splicing in response to extracellular signals, such as altered splicing of CD44 in response to phorbol ester treatment of T cells. RNA binding and activity of SAM68 is regulated by upstream signals through phosphorylation and modulating of its interaction with other proteins, itself, and with RNA. Phorbol ester treatment of T cells stimulates the ras/ Map kinase pathway, activating Erk and phosphorylation of Sam68, inducing alternative splicing of CD44 and perhaps other cellular RNA targets. Sam68 is localized in the nucleus to a specific substructure called the Sam68/SLM Nuclear Bodies, colocalizing with splicing factors and helping to link signal transduction with RNA processing. Sam68 has been suggested to play a role in a variety of pathways, including insulin signaling and HIV gene expression, substituting for the activity of viral Rev protein, and being regulated by arginine methylation as well as phosphorylation. In addition to the role of Sam68 regulating posttranscriptional gene expression, Sam68 also interacts with transcription factors such as CBP and appears to regulate gene expression. Sam68 also appears to play a role in cell cycle progression through influencing RNA processing. During mitosis SAM68 is tyrosine phosphorylated and associated with Src. The interaction of Sam68 with RNA is repressed by this phosphorylation, whereas interaction of Sam68 with Ras-GAP is stimulated by phosphorylation. Sam68 appears to be downregulated in tumors and transformed cells and its expression is reduced during mitosis, suggesting it inhibits proliferation. The RNA binding domain in Sam68, called a KH domain, is absent in a spl…
MCID: MC00527665
PMOID: PMO:00014513
Subclass_of: Genetic Information Processing Pathway
Synonym: Regulation of Splicing through Sam68
Tree Number: T4.6.14
database_cross_reference: NCI:C39228
database_cross_reference: NCI_BioC:C39228

Telomere Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: Telomeres, which define the ends of chromosomes, consist of short, tandemly repeated DNA sequences loosely conserved in eukaryotes. Telomerase is a ribonucleoprotein complex which in vitro recognizes a single-stranded G-rich telomere primer and adds multiple telomeric repeats to its 3-prime end by using an RNA template. Telomerase may also have a role in de novo formation of telomeres. Telomerase has been identified in many cultured cell lines and actively dividing cell types. The active reverse transcriptase component has been identified as the TERT protein. The presence of this factor determines the availability of the telomerase function. The TERT protein has a high turnover rate and its expression is regulated by factors that promote growth (c-MYC, v-k-ras, Bcl-2, and E6) and inhibiting factors (RB and p53) that promote cell death or that block cell division. It appears that the regulation of active telomerase has many levels and can be inhibited by TEP1 not releasing TERT or by TRF1 which binds the end repeats and prevents access to the chromosome ends. Additional modulation is due to phosphorylation by PKC and AKT or dephosphorylation by PP2A. Human telomeres consist of many kilobases of (TTAGGG)n together with various associated proteins. Small amounts of these terminal sequences are lost from the tips of the chromosomes during each S phase because of incomplete DNA replication, but de novo addition of TTAGGG repeats by the enzyme telomerase compensates for this loss. Many human cells progressively lose terminal bases with each cell division, a loss that correlates with the apparent absence of telomerase in these cells. There has been considerable interest in the possible relationship between human telomeres and cellular senescence and immortalization. This interest includes the question of a role in the malignant process and the question of the use of telomerase inhibitors as anti-tumor drugs. (This definition may be outdated - see the DesignNote.)
MCID: MC00525413
PMOID: PMO:00014514
Subclass_of: Genetic Information Processing Pathway
Synonym: Telomeres, Telomerase, Cellular Aging, and Immortality
Tree Number: T4.6.15
database_cross_reference: NCI:C39247
database_cross_reference: NCI_BioC:C39247

Transcriptional Repression by DNA Methylation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: Tumorigenesis is known to be a multistep process in which defects in various cancer genes accumulate. Epigenetic modifications, most importantly DNA methylation events, are frequently involved in transcriptional changes in both tumor suppressor genes and oncogenes. Methylation of cytosine at CpG dinucleotides is a common feature of higher eukaryotic genomes. DNA methylation in the promoter regions of genes is generally correlated with gene silencing. Two underlying mechanisms have been identified. First, binding of transcription factors or enhancer blocking elements, such as CTCF, may be inhibited by DNA methylation. The second and more general mechanism involves proteins that detect methylated DNA through methyl CpG-binding domains (MBDs). Four of these proteins-MBD1, MBD2, MBD3, and MeCP2-have been implicated in methylation-dependent repression of transcription. These proteins mediate recruitment of repressor complexes that include histone deacetylases (HDACs). HDACs remove acetyl groups from lysine residues of histones H3 and H4 that results in condensation of chromatin and thus limit access of transcription factors to promoter regions of genes localized nearby. Well-studied co-repressor complexes include Sin3A and Mi-2/NuRD. MeCP2, a polypeptide characterized by an MBD and a transcriptional repression domain that specifically binds methylated DNA, copurifies with the Sin3A/HDAC corepressor complex. MeCP1 complex is composed of 10 major polypeptides including MBD2 and all of the known NuRD complex components. The two protein complexes share four polypeptides: HDAC1, HDAC2, RbAp46, and RbAp48. In addition, each complex contains unique polypeptides (Sin3A, SAP30, and SAP18 in the Sin3 complex, and Mi2, MTA1, MTA2 and MBD3 in the NuRD complex). The NuRD complex possesses nucleosome remodeling activity because of the presence of Mi2, a member of the SWI2/SNF2 helicase/ATPase family. This complex preferentially binds, remodels, and deacetylates methylated nucleosomes.…
MCID: MC01394269
PMOID: PMO:00014515
Subclass_of: Genetic Information Processing Pathway
Synonym: DNA Methylation Pathway
Synonym: Mechanisms of Transcriptional Repression by DNA Methylation
Tree Number: T4.6.16
database_cross_reference: NCI:C91331
database_cross_reference: NCI_BioC:C91331

tRNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
MCID: MC01394275
PMOID: PMO:00014516
Subclass_of: Genetic Information Processing Pathway
Synonym: tRNA Biosynthesis (Eukaryotes)
Tree Number: T4.6.17
database_cross_reference: NCI:C38874
database_cross_reference: NCI_KEGG:C38874

Ubiquitin-mediated Proteolysis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
Definition: Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
MCID: MC00527800
PMOID: PMO:00014517
Subclass_of: Genetic Information Processing Pathway
Synonym: Ubiquitin-mediated Proteolysis
Tree Number: T4.6.18
database_cross_reference: NCI:C38881
database_cross_reference: NCI_KEGG:C38881

Metabolic Pathway
type: Class
subclass of: Biochemical Pathway
Definition: An elaboration of the known steps and interactions for the metabolism of a compound.
MCID: MC01393920
PMOID: PMO:00014518
Subclass_of: Biochemical Pathway
Synonym: Metabolic Pathways
Synonym: Metabolic pathway
Synonym: Metabolic pathway (function)
Synonym: Metabolic pathway, function
Synonym: Metabolic pathway, function (observable entity)
Synonym: Metabolism
Synonym: Pathway, Metabolic
Synonym: Pathways, Metabolic
Synonym: metabolic pathway
Synonym: metabolic pathways
Tree Number: T4.7
database_cross_reference: CHV:0000057416
database_cross_reference: MSH:D053858
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C18611
database_cross_reference: NCI_KEGG:C18611
database_cross_reference: SNOMEDCT_US:129457002

Amino Acid Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
MCID: MC00523053
PMOID: PMO:00014519
Subclass_of: Metabolic Pathway
Synonym: Amino Acid Metabolism - Reference Pathway
Tree Number: T4.7.1
database_cross_reference: NCI:C39730
database_cross_reference: NCI_KEGG:C39730

Alanine, Aspartate and Glutamate Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC01393780
PMOID: PMO:00014520
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Alanine, aspartate and glutamate metabolism
Tree Number: T4.7.1.1
database_cross_reference: NCI:C91410
database_cross_reference: NCI_KEGG:C91410

Arginine and Proline Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC00523106
PMOID: PMO:00014521
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Arginine and Proline Metabolism
Synonym: Urea Cycle and Metabolism of Amino Groups
Tree Number: T4.7.1.2
database_cross_reference: NCI:C38785
database_cross_reference: NCI_KEGG:C38785

Arginine, Histidine, Glutamate, Glutamine, and Proline Degradation Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
Definition: Glutamine is converted to glutamate by glutaminase, or several other enzymes, by the removal of the amide nitrogen. Proline is first converted to a Schiff base and then converted by hydrolysis to glutamate-5-semialdehyde. All of these changes occur on the same carbon. Arginine and histidine contain 5 adjacent carbons and a sixth carbon attached through a nitrogen atom. The catabolism of these amino acids is thus slightly more complicated than glutamine or proline. Arginine is converted to ornithine and urea. Ornithine is further transaminated to produce glutamate-5-semialdehyde. Glutamate-5-semialdehyde is converted to glutamate. Tetrahydrofolate is the cofactor in the final step converting histidine to glutamate. Transamination or deamination of glutamate produces a-ketoglutarate which feeds into the citric acid cycle. (This definition may be outdated - see the DesignNote.)
MCID: MC00523105
PMOID: PMO:00014522
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Catabolic Pathways for Arginine, Histidine, Glutamate, Glutamine, and Proline
Tree Number: T4.7.1.3
database_cross_reference: NCI:C38993
database_cross_reference: NCI_BioC:C38993

Biosynthesis of Cysteine Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
Definition: In animals, the sulfur-containing amino acid cysteine is synthesized from homocysteine, which is itself derived from metabolism of the amino acid methionine. Methionine is an essential amino acid for animals, making cysteine indirectly an essential amino acid as well. Homocysteine condenses with serine to form cystathionine, which is deaminated and hydrolyzed to form cysteine and alpha-ketobutyrate. While the sulfur in cysteine comes from homocysteine, the rest of the molecule comes from the initial serine residue. Cysteine biosynthesis occurs by a distinct mechanism in plants and prokaryotes. Cysteine is an important amino acid for all organisms due to the role it plays in protein folding. The formation of disulfide linkages between cysteine residues helps to stabilize the tertiary and quaternary structure of proteins. Disulfide linkages are most common in secreted proteins, where proteins are exposed to more oxidizing conditions that are found in the cellular interior. Elevated blood levels of homocysteine are a risk factor for the development of cardiovascular disease. One of the causes of elevated homocysteine is a genetic lack of cystathionine beta-synthase and excess methionine intake may be another explanation. Control of methionine intake and supplementing folic acid and vitamin B12 in the diet are used to lower homocysteine levels. (This definition may be outdated - see the DesignNote.)
MCID: MC01394357
PMOID: PMO:00014523
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Biosynthesis of Cysteine in Mammals
Synonym: Mammalian Pathway for Cysteine Biosynthesis
Tree Number: T4.7.1.4
database_cross_reference: NCI:C91319
database_cross_reference: NCI_BioC:C91319

Biosynthesis of Glycine and Serine Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
Definition: Intermediates in energy production pathways such as glycolysis and the Kreb's cycle are commonly the starting point for the biosynthesis of amino acids. The glycolytic intermediate 3-phosphoglycerate is the starting point for the biosynthesis of serine and glycine. First, 3-phosphoglycerate is oxidized and then transaminated to produce 3-phosphoserine. Phosphoserine hydrolase hydrolyzes the phosphate in 3-phosphoserine to produce serine. The side chain carbon of serine is removed to create glycine, which has only hydrogen as its side chain. The removal of the serine side chain is accomplished by transferring the carbon to tetrahydrofolate, a carrier of one-carbon groups. Genetic deficiency of the first enzyme in the pathway, 3-phosphoglycerate dehydrogenase, leads to impaired myelination of neurons and impaired development of the central nervous system. (This definition may be outdated - see the DesignNote.)
MCID: MC01394360
PMOID: PMO:00014524
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Biosynthesis of Glycine and Serine
Tree Number: T4.7.1.5
database_cross_reference: NCI:C91320
database_cross_reference: NCI_BioC:C91320

Biosynthesis of Spermidine and Spermine Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
Definition: The polyamines spermidine and spermine are expressed in a variety of tissues and are involved in the regulation of apoptosis, cellular proliferation, and progression through the cell cycle. Depletion of polyamines appears to reduce cell growth, and increased polyamine expression is associated with the cancer development and progression, making polyamine biosynthesis a target for the control of cancer. As positively charged amines, spermine and spermidine interact with DNA and may exert some of their effects through this interaction. Ornithine, one of the starting materials for polyamine biosynthesis, is derived from the amino acid arginine as part of the urea cycle. The enzyme ornithine decarboxylase produces putrescine from ornithine. Amino-propyl groups from decarboxylated adoMet are progressively added to putrescine to produce first spermidine and then spermine. Ornithine decarboxylase expression appears to be induced in some types of cancer, particularly skin cancer, and ODC inhibition to cause tumor regression. (This definition may be outdated - see the DesignNote.)
MCID: MC01394340
PMOID: PMO:00014525
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Biosynthesis of Spermidine and Spermine
Tree Number: T4.7.1.6
database_cross_reference: NCI:C91324
database_cross_reference: NCI_BioC:C91324

Catabolic Pathway for Asparagine and Aspartate
type: Class
subclass of: Amino Acid Metabolism Pathway
Definition: Aspartate and asparagine are catabolized into oxaloacetate and the Kreb's cycle in a fairly direct pathway for amino acids with four carbons. The first step for asparagine catabolism is hydrolysis by the enzyme asparaginase, releasing aspartate and ammonia. Aspartate is then transaminated by aspartate transaminase to exchange its amino group onto alpha-ketoglutarate and be converted into oxaloacetate. As part of the Kreb's cycle, the carbon skeleton of oxaloacetate can generate energy and provide material for biosynthesis. The enzyme asparaginase is used as a cancer treatment through injection. Some cancers such as leukemias are highly dependent on asparagine circulating in the blood that comes from the diet. The required asparagine helps to support the rapid growth of malignant cells. Injection of asparaginase metabolizes the asparagine in the blood, withdrawing the supply of this essential nutrient from tumor cells, and causing asparagine-dependent tumor cells to die. Normal cells provide enough asparagine for their own needs through biosynthesis and are affected to a lesser extent by this treatment. (This definition may be outdated - see the DesignNote.)
MCID: MC01394362
PMOID: PMO:00014526
Subclass_of: Amino Acid Metabolism Pathway
Tree Number: T4.7.1.7
database_cross_reference: NCI:C91321
database_cross_reference: NCI_BioC:C91321

Catabolic Pathways for Alanine, Glycine, Serine, Cysteine, Tryptophan, and Threonine
type: Class
subclass of: Amino Acid Metabolism Pathway
Definition: Amino acids in the diet have one of two fates - either they are incorporated into proteins or they are broken down for energy and metabolic intermediates. They are not stored and the body also does not excrete them intact. The metabolic pathways that lead to degradation of amino acids funnel their carbon chains into metabolic intermediates that generate energy, and their amino groups into the urea cycle to be excreted. The amino acids alanine, glycine, serine, cysteine, tryptophan and threonine all have a common endpoint, the metabolic intermediate pyruvate. Threonine is converted to glycine through the removal of an acetaldehyde group, and glycine is then converted to serine, then pyruvate. More than one path can remove the sulfur and nitrogen groups of serine to create pyruvate. Part of tryptophan is found in alanine, which is converted directly to pyruvate through transamination. The removal of amino nitrogens commonly occurs through transamination, transferring the nitrogen to alpha-ketobutyrate to create glutamate. All of these amino acids are termed glucogenic since the pyruvate resulting from their metabolism can enter gluconeogenesis to create glucose. Pyruvate can also be converted by pyruvate dehydrogenase into acetyl-CoA, which can enter into the Kreb's cycle to generate ATP, be converted to ketone bodies, or be directed into fatty acid biosynthesis. The importance of amino acid degradation is demonstrated by a genetic defect in serine hydroxymethyl transferase. In individuals with this condition, glycine accumulates to toxic levels in the body due to a lack of other mechanisms of metabolism. (This definition may be outdated - see the DesignNote.)
MCID: MC01394333
PMOID: PMO:00014527
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Conversion of Alanine, Glycine, Serine, Cysteine, Tryptophan, and Threonine into Pyruvate
Tree Number: T4.7.1.8
database_cross_reference: NCI:C91322
database_cross_reference: NCI_BioC:C91322

Cysteine and Methionine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC01393784
PMOID: PMO:00014528
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Cysteine and methionine metabolism
Tree Number: T4.7.1.9
database_cross_reference: NCI:C91411
database_cross_reference: NCI_KEGG:C91411

Glycine, Serine and Threonine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
Definition: Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis, and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate.
MCID: MC00523814
PMOID: PMO:00014529
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Glycine, Serine and Threonine Metabolism
Tree Number: T4.7.1.10
database_cross_reference: NCI:C38817
database_cross_reference: NCI_KEGG:C38817

Histidine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC00390182
PMOID: PMO:00014530
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Histidine Metabolism
Synonym: histidine metabolic process
Synonym: histidine metabolism
Tree Number: T4.7.1.11
database_cross_reference: GO:GO:0006547
database_cross_reference: NCI:C38824
database_cross_reference: NCI_KEGG:C38824

Lysine Biosynthesis Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC00389977
PMOID: PMO:00014531
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Lysine Biosynthesis
Synonym: lysine anabolism
Synonym: lysine biosynthesis
Synonym: lysine biosynthetic process
Synonym: lysine formation
Synonym: lysine synthesis
Tree Number: T4.7.1.12
database_cross_reference: GO:GO:0009085
database_cross_reference: NCI:C38832
database_cross_reference: NCI_KEGG:C38832

Lysine Degradation Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC01394168
PMOID: PMO:00014532
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Lysine Degradation
Tree Number: T4.7.1.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38833
database_cross_reference: NCI_KEGG:C38833

Methionine, Isoleucine, Threonine and Valine Degradation Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
Definition: The carbon chains of methionine, isoleucine, threonine, and valine are broken down to produce succinyl-CoA, which feeds into the Citric Acid Cycle. Methionine donates its methyl group via S-adenosylmethionine to one of several acceptors and the four remaining carbons are the backbone of propionyl-CoA that is subsequently converted to succinyl-CoA. The transdeamination and decarboxylation of valine are followed by a series of steps resulting in the formation of propionyl-CoA. Isoleucine also undergoes transdeamination, followed by oxidative decarboxylation. These steps yield propionyl-CoA as well as acetyl-CoA. Deficiency in the steps that convert isoleucine to propionyl-CoA causes sudden unexplained infant death, Reye-like syndrome, cardiomyopathy, and skeletal myopathy. (This definition may be outdated - see the DesignNote.)
MCID: MC00524314
PMOID: PMO:00014533
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine
Tree Number: T4.7.1.14
database_cross_reference: NCI:C39151
database_cross_reference: NCI_BioC:C39151

Phenylalanine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC00452050
PMOID: PMO:00014534
Subclass_of: Amino Acid Metabolism Pathway
Synonym: L-phenylalanine metabolic process
Synonym: L-phenylalanine metabolism
Synonym: Phenylalanine Metabolism
Synonym: phenylalanine metabolism
Tree Number: T4.7.1.15
database_cross_reference: GO:GO:0006558
database_cross_reference: NCI:C38848
database_cross_reference: NCI_KEGG:C38848

Phenylalanine, Tyrosine and Tryptophan Biosynthesis Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC00527464
PMOID: PMO:00014535
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Phenylalanine, Tyrosine and Tryptophan Biosynthesis
Tree Number: T4.7.1.16
database_cross_reference: NCI:C38849
database_cross_reference: NCI_KEGG:C38849

Tryptophan Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC00390146
PMOID: PMO:00014536
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Tryptophan Metabolism
Synonym: tryptophan metabolic process
Synonym: tryptophan metabolism
Tree Number: T4.7.1.17
database_cross_reference: GO:GO:0006568
database_cross_reference: NCI:C38875
database_cross_reference: NCI_KEGG:C38875

Tyrosine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC00390149
PMOID: PMO:00014537
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Tyrosine Metabolism
Synonym: metabolism tyrosine
Synonym: tyrosine metabolic process
Synonym: tyrosine metabolism
Tree Number: T4.7.1.18
database_cross_reference: CHV:0000055334
database_cross_reference: GO:GO:0006570
database_cross_reference: NCI:C38879
database_cross_reference: NCI_KEGG:C38879

Valine, Leucine and Isoleucine Biosynthesis Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC00527901
PMOID: PMO:00014538
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Valine, Leucine and Isoleucine Biosynthesis
Tree Number: T4.7.1.19
database_cross_reference: NCI:C38883
database_cross_reference: NCI_KEGG:C38883

Valine, Leucine and Isoleucine Degradation Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
MCID: MC00527902
PMOID: PMO:00014539
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Valine, Leucine and Isoleucine Degradation
Tree Number: T4.7.1.20
database_cross_reference: NCI:C38884
database_cross_reference: NCI_KEGG:C38884

Biosynthesis of Secondary Metabolites Pathway
type: Class
subclass of: Metabolic Pathway
MCID: MC00523220
PMOID: PMO:00014540
Subclass_of: Metabolic Pathway
Synonym: Biosynthesis of Secondary Metabolites - Reference Pathway
Tree Number: T4.7.2
database_cross_reference: NCI:C39734
database_cross_reference: NCI_KEGG:C39734

Butirosin and Neomycin Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
MCID: MC01393790
PMOID: PMO:00014541
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Butirosin and neomycin biosynthesis
Tree Number: T4.7.2.1
database_cross_reference: NCI:C91413
database_cross_reference: NCI_KEGG:C91413

Caffeine Metabolism Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
MCID: MC01394124
PMOID: PMO:00014542
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Caffeine metabolism
Tree Number: T4.7.2.2
database_cross_reference: NCI:C91437
database_cross_reference: NCI_KEGG:C91437

Flavonoids, Stilbene and Lignin Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
MCID: MC00526495
PMOID: PMO:00014543
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Flavonoids, Stilbene and Lignin Biosynthesis
Tree Number: T4.7.2.3
database_cross_reference: NCI:C38808
database_cross_reference: NCI_KEGG:C38808

Formation of Ketone Bodies from Acetyl-CoA Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
Definition: The acetyl-CoA produced by mitochondrial beta-oxidation of fatty acids enters the Kreb's cycle to produce energy, but that is not the only fate of acetyl-CoA. In liver mitochondria, some acetyl-CoA is converted to acetoacetate, beta-hydroxybutyrate, and acetone, collectively called ketone bodies. Ketone bodies are transported to other tissues such as brain, muscle or heart where they are converted back to acetyl-CoA to serve as an energy source. The brain normally uses only glucose for energy, but during starvation ketone bodies can become the main energy source for the brain. In the metabolic condition called ketosis, ketone bodies are produced faster than they are consumed by tissues and the smell of acetone can be detected on a person's breath. The smell of acetone is one indication that a person may have diabetes. The consumption of high-fat/low carbohydrate diets has been used as a weight loss program by many, intentionally inducing ketosis to consume fat stores, but these ketogenic diets can cause unwanted side effects related to increased urea production resulting from protein intake and risk of heart disease from increased cholesterol and fat intake. (This definition may be outdated - see the DesignNote.)
MCID: MC01394351
PMOID: PMO:00014544
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Formation of Ketone Bodies from Acetyl-CoA
Tree Number: T4.7.2.4
database_cross_reference: NCI:C91328
database_cross_reference: NCI_BioC:C91328

Indole and Ipecac Alkaloid Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
MCID: MC00524069
PMOID: PMO:00014545
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Indole alkaloid biosynthesis
Synonym: Indole and Ipecac Alkaloid Biosynthesis
Tree Number: T4.7.2.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38826
database_cross_reference: NCI_KEGG:C38826

Isoquinoline Alkaloid Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
PMOID: PMO:00014546
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Tree Number: T4.7.2.6

Terpenoid Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
MCID: MC00390685
PMOID: PMO:00014547
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Terpenoid Biosynthesis
Synonym: Terpenoid backbone biosynthesis
Synonym: terpenoid anabolism
Synonym: terpenoid biosynthesis
Synonym: terpenoid biosynthetic process
Synonym: terpenoid formation
Synonym: terpenoid synthesis
Tree Number: T4.7.2.7
database_cross_reference: GO:GO:0016114
database_cross_reference: NCI:C38872
database_cross_reference: NCI_KEGG:C38872

Tropane, Piperidine and Pyridine Alkaloid Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
MCID: MC01393850
PMOID: PMO:00014548
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Alkaloid Biosynthesis II
Synonym: Tropane, piperidine and pyridine alkaloid biosynthesis
Tree Number: T4.7.2.8
database_cross_reference: NCI:C38777
database_cross_reference: NCI_KEGG:C38777

Carbohydrate Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
Definition: An elaboration of a sequence of biological or biochemical events that play a role in the metabolism of carbohydrates.
MCID: MC00526061
PMOID: PMO:00014549
Subclass_of: Metabolic Pathway
Synonym: Carbohydrate Metabolism - Reference Pathway
Tree Number: T4.7.3
database_cross_reference: NCI:C39726
database_cross_reference: NCI_KEGG:C39726

Amino and Nucleotide Sugars Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC01393848
PMOID: PMO:00014550
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Amino sugar and nucleotide sugar metabolism
Synonym: Aminosugars Metabolism
Synonym: Nucleotide Sugars Metabolism
Tree Number: T4.7.3.1
database_cross_reference: NCI:C38840
database_cross_reference: NCI_KEGG:C38840

Ascorbate and Aldarate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00523114
PMOID: PMO:00014551
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Ascorbate and Aldarate Metabolism
Tree Number: T4.7.3.2
database_cross_reference: NCI:C38786
database_cross_reference: NCI_KEGG:C38786

Butanoate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00523333
PMOID: PMO:00014552
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Butanoate Metabolism
Tree Number: T4.7.3.3
database_cross_reference: NCI:C38793
database_cross_reference: NCI_KEGG:C38793

Citrate Cycle (TCA Cycle) Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
Definition: The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation of carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle, but contain genes for specific segments.
MCID: MC00526241
PMOID: PMO:00014553
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Citrate Cycle (TCA cycle)
Tree Number: T4.7.3.4
database_cross_reference: NCI:C38797
database_cross_reference: NCI_KEGG:C38797

Feeder Pathways for Glycolysis
type: Class
subclass of: Carbohydrate Metabolism Pathway
Definition: The glycolytic pathway begins with the simple sugar glucose and leads to pyruvate and eventually the Kreb's cycle. Dietary carbohydrates include a variety of sugars that are funneled into glycolysis to supply energy, including other monosaccharides, disaccharides, and polysaccharides like starch. Fructose is an abundant monosaccharide in fruit, and is also found along with glucose in the common disaccharide sucrose. Fructose enters glycolysis by different pathways in the liver and muscle. In muscle, fructose is a substrate of hexokinase, like glucose, and enters the pathway directly as fructose 6-phosphate. In liver, hexokinase is present in very low levels and fructose passes through a more complex pathway. Fructose is first phosphorylated to form fructose 1-phosphate, which is then split into glyceraldehyde and dihydroxyacetone phosphate to enter glycolysis as glyceraldehyde 3-phosphate. The sugar mannose also enters glycolysis at this point, first being converted to mannose 6-phosphate that is then isomerized to produce fructose 6-phosphate. Lactose is a disaccharide found in milk, and is composed of glucose and galactose. Galactose only differs from glucose in its stereochemistry at one position, but must be converted to glucose to enter glycolysis. The first step is phosphorylation to produce galactose 1-phosphate. Then, a UDP nucleotide group is exchanged between galactose 1-phosphate and UDP-glucose. The result of this reaction is the production of glucose 1-phosphate and UDP-galactose. UDP-galactose is enzymatically converted to UDP-glucose, which is then converted to glucose 1-phosphate in the next round of this loop. Glucose 1-phosphate is isomerized to produce glucose 6-phosphate, part of the glycolytic pathway. The complex polysaccharides starch and glycogen differ in their source and in their structure (they have different bonds between each individual sugar unit) but they are both composed entirely of glucose subunits polymerized together. Starch is fo…
MCID: MC01394343
PMOID: PMO:00014554
Subclass_of: Carbohydrate Metabolism Pathway
Tree Number: T4.7.3.5
database_cross_reference: NCI:C91325
database_cross_reference: NCI_BioC:C91325

Fructose and Mannose Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00526557
PMOID: PMO:00014555
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Fructose and Mannose Metabolism
Tree Number: T4.7.3.6
database_cross_reference: NCI:C38810
database_cross_reference: NCI_KEGG:C38810

Galactose Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00389845
PMOID: PMO:00014556
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Galactose Metabolism
Synonym: galactose metabolic process
Synonym: galactose metabolism
Tree Number: T4.7.3.7
database_cross_reference: GO:GO:0006012
database_cross_reference: NCI:C38811
database_cross_reference: NCI_KEGG:C38811

Glycolysis Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
Definition: In glycolysis, the six-carbon sugar glucose is oxidized and split in two halves, to create two molecules of pyruvate (3 carbons each) from each molecule of glucose. Along the way, the cell extracts a relatively small amount of energy from glucose in the form of ATP, 2 ATP molecules collected for each glucose molecule that starts down the glycolytic path. The pyruvate produced has one of three metabolic fates, to either become acetyl-CoA, ethanol, or lactate. When oxygen is available, the pyruvate can be converted to acetyl-CoA and enter the Krebs Cycle, where the acetyl-CoA will be completely oxidized and generate ATP through oxidative phosphorylation. Fermentation is much less efficient than oxidative phosphorylation in making ATP, creating only 2 ATP per glucose while oxidative phosphorylation creates 36 ATP per glucose in mammalian cells. Oxidative phosphorylation does not work in the absence of oxygen, however, and in the absence of oxygen glycolysis is forced to a halt due to a lack of NAD+, unless NAD+ is regenerated through fermentation. In mammalian muscle, strenuous exertion can create conditions in which oxygen is consumed faster than blood can provide it, forcing the muscle to use fermentation and create lactic acid; it is the lactic acid that makes your muscles sore after a workout. There are ten enzymes that catalyze the steps in glycolysis that convert glucose into pyruvate, and the entire pathway is located in the cytoplasm of eukaryotic cells. The activity of the pathway is regulated at key steps to ensure that glucose consumption and energy production match the needs of the cell. The steps along the pathway each involve a change in the free energy of the products and reactants, and as long as the overall change in free energy is negative, the reaction continues forward, like water flowing down hill to its lowest energy point. The key steps in the regulation of glycolysis, or any pathway, are those that catalyze the rate-limiting, irreversible steps …
MCID: MC00523824
PMOID: PMO:00014557
Subclass_of: Carbohydrate Metabolism Pathway
Tree Number: T4.7.3.8
database_cross_reference: NCI:C39095
database_cross_reference: NCI_BioC:C39095

Glycolysis/Gluconeogenesis Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
Definition: Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module, which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from non-carbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths.
MCID: MC00523821
PMOID: PMO:00014558
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Glycolysis / Gluconeogenesis
Tree Number: T4.7.3.9
database_cross_reference: NCI:C38818
database_cross_reference: NCI_KEGG:C38818

Glyoxylate and Dicarboxylate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00523828
PMOID: PMO:00014559
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Glyoxylate and Dicarboxylate Metabolism
Tree Number: T4.7.3.10
database_cross_reference: NCI:C38823
database_cross_reference: NCI_KEGG:C38823

Inositol Phosphate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00524120
PMOID: PMO:00014560
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Inositol Metabolism
Synonym: Inositol Phosphate Metabolism
Synonym: inositol phosphate metabolic process
Synonym: inositol phosphate metabolism
Tree Number: T4.7.3.11
database_cross_reference: GO:GO:0043647
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38828
database_cross_reference: NCI_KEGG:C38828

Lactose Synthesis Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
Definition: The synthesis of glycosidic bonds between monosaccharides requires energy input, energy that is provided by joining sugar monomers to a nucleotide such as UDP. Glycosyltransferases join two sugar monomers together, with UDP as the leaving group that drives the reaction forward. One glycosyltransferases is galactosyltransferase. Galactosyltransferase catalyzes the formation of a glycosidic bond between galactose and N-acetyl-D-glucosamine to create N-acetyllactosamine (D-galactosyl-N-acetyl-D-glucosamine), found in the oligosaccharides of glycoproteins. Galactosyltransferase is broadly expressed. This enzyme also catalyzes the synthesis of the disaccharide lactose, the sugar found in milk. Although this enzyme is broadly expressed, lactose production only occurs in mammary glands. Lactose production is restricted to the mammary glands because galactosyltransferase alone does not have the substrate specificity required to produce lactose. The complete lactose synthase complex includes galactosyltransferase and another non-catalytic subunit, alpha-lactalbumin. In the presence of alpha-lactalbumin, galactosyltransferase substrate specificity is switched to use glucose, resulting in lactose production rather than N-acetyllactosamine. The folding of alpha-lactalbumin, which is related to lysozyme, has been studied extensively as a model of the mechanisms involved in protein folding. (This definition may be outdated - see the DesignNote.)
MCID: MC00390516
PMOID: PMO:00014561
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Lactose Synthesis
Synonym: lactose anabolism
Synonym: lactose biosynthesis
Synonym: lactose biosynthetic process
Synonym: lactose formation
Synonym: lactose synthesis
Tree Number: T4.7.3.12
database_cross_reference: GO:GO:0005989
database_cross_reference: NCI:C91326
database_cross_reference: NCI_BioC:C91326

Leloir Pathway of Galactose Metabolism
type: Class
subclass of: Carbohydrate Metabolism Pathway
Definition: Galactose is a hexose sugar found in the disaccharide lactose. Galactose has six carbons like glucose and differs from glucose only in the stereochemistry of one carbon, C4. The enzymes of carbohydrate metabolism are specific enough that galactose must be changed to glucose before it can enter glycolysis. To convert galactose to glucose, it is first phosphorylated by galactokinase to produce galactose-1-phosphate. Galactose is then exchanged with the glucose group in UDP-glucose to create UDP-galactose and release glucose-1-phosphate. An epimerase enzyme changes the stereochemistry of C4 in UDP-galactose, creating UDP-glucose. In the next round of the transfer reaction, this glucose is released as glucose-1-phosphate. Once released, glucose-1-phosphate is converted to glucose-6-phosphate and can enter glycolysis to generate energy. Mutation of the kinase, the transferase or the epimerase can result in clinical deficiencies in galactose metabolism known as galactosemias. Galactosemias range in severity depending on the nature of the genetic change, and are usually treated through avoidance of galactose in the diet, primarily from lactose in dairy products. (This definition may be outdated - see the DesignNote.)
MCID: MC01393896
PMOID: PMO:00014562
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Leloir pathway of galactose metabolism
Tree Number: T4.7.3.13
database_cross_reference: NCI:C39087
database_cross_reference: NCI_BioC:C39087

Oxidative Reactions of the Pentose Phosphate Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
Definition: One form of chemical energy used to drive biosynthetic reactions forward is the reducing power of the energy carrier NADPH. NADPH is essential to drive the biosynthesis of fatty acids and cholesterol for example. While NADPH is an important energy carrier and is closely related to the high-energy electron carrier NADH, NADPH is distinct from NADH in several ways. NADH in oxidative phosphorylation in mitochondria transports chemical energy from the Kreb's cycle to the electron transport chain, but NADPH does not play this role. The cell keeps its pools of NADH and NADPH isolated biochemically, through the specificity of the enzymes that use and generate these cofactors. Enzymes that metabolize NADH and NADPH are highly specific for one cofactor or the other and are in different pathways. While NADH is produced in mitochondria by the Kreb's cycle, NADPH is produced through a pathway called the pentose phosphate pathway. Since one of the main purposes of this pathway is to produce NADPH for biosynthesis, this pathway occurs most predominantly in tissues like liver, fat cells, or adrenal glands that are involved in fatty acid and cholesterol biosynthesis. This pathway starts with glucose-6-phosphate, the first committed step in glycolysis, and can provide an alternative route to glycolysis for energy production. The first portion of the pentose phosphate pathway involves the oxidation of glucose in three steps, with the concomitant production of NADPH. The first step in the pentose phosphate pathway is catalyzed by glucose-6-phosphate dehydrogenase. In normal red blood cells, the NADPH produced by glucose-6-phosphate dehydrogenase is used to regenerate glutathione and protect cell membranes. Genetic deficiency in the activity of this enzyme is very common in some populations, and can result in anemias caused by fragile red blood cells. In the second and third steps, further oxidation makes more NADPH and releases carbon dioxide, shortening the sugar from six carbons to …
MCID: MC01394348
PMOID: PMO:00014563
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: NADPH Pathway
Synonym: Oxidative Phase of the Pentose Phosphate Pathway
Tree Number: T4.7.3.14
database_cross_reference: NCI:C91327
database_cross_reference: NCI_BioC:C91327

Pentose and Glucuronate Interconversions Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00527432
PMOID: PMO:00014564
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Pentose and Glucuronate Interconversions
Tree Number: T4.7.3.15
database_cross_reference: NCI:C38846
database_cross_reference: NCI_KEGG:C38846

Pentose Phosphate Cycle Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
Definition: The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P.
MCID: MC00527431
PMOID: PMO:00014565
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Pentose Phosphate Cycle
Tree Number: T4.7.3.16
database_cross_reference: NCI:C38847
database_cross_reference: NCI_KEGG:C38847

Propanoate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00524989
PMOID: PMO:00014566
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Propanoate Metabolism
Tree Number: T4.7.3.17
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38854
database_cross_reference: NCI_KEGG:C38854

Pyruvate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00392083
PMOID: PMO:00014567
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Pyruvate Metabolism
Synonym: pyruvate metabolic process
Synonym: pyruvate metabolism
Tree Number: T4.7.3.18
database_cross_reference: GO:GO:0006090
database_cross_reference: NCI:C38860
database_cross_reference: NCI_KEGG:C38860

Starch and Sucrose Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
MCID: MC00525226
PMOID: PMO:00014568
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Starch and Sucrose Metabolism
Tree Number: T4.7.3.19
database_cross_reference: NCI:C38867
database_cross_reference: NCI_KEGG:C38867

The Citric Acid Cycle
type: Class
subclass of: Carbohydrate Metabolism Pathway
Definition: The Krebs cycle, also called the citric acid cycle, is a fundamental metabolic pathway involving eight enzymes essential for energy production through aerobic respiration, and, like glycolysis, arose early in evolution. This pathway is also an important source of biosynthetic building blocks used in gluconeogenesis, amino acid biosynthesis, and fatty acid biosynthesis. The Krebs cycle takes place in mitochondria where it oxidizes acetyl-CoA, releasing carbon dioxide and extracting energy primarily as the reduced high-energy electron carriers NADH and FADH2. NADH and FADH2 transfer chemical energy from metabolic intermediates to the electron transport chain to create a different form of energy, a gradient of protons across the inner mitochondrial membrane. The energy of the proton gradient in turn drives synthesis of the high-energy phosphate bonds in ATP, the common energy currency of the cell used to drive a huge variety of reactions and processes. An acetyl-CoA molecule (2 carbons) enters the cycle when citrate synthase condenses it with oxaloacetate (4 carbons) to create citrate (6 carbons). One source of the acetyl-CoA that enters the Krebs cycle is the conversion of pyruvate from glycolysis to acetyl-CoA by pyruvate dehydrogenase. Acetyl-CoA is a key metabolic junction, derived not only from glycolysis but also from the oxidation of fatty acids. As the cycle proceeds, the Krebs cycle intermediates are oxidized, transferring their energy to create reduced NADH and FADH2. The oxidation of the metabolic intermediates of the pathway also releases two carbon dioxide molecules for each acetyl-CoA that enters the cycle, leaving the net carbons the same with each turn of the cycle. This carbon dioxide, along with more released by pyruvate dehydrogenase, is the source of CO2 released into the atmosphere when you breathe. The Krebs cycle, like other metabolic pathways, is tightly regulated to efficiently meet the needs of the cell and the organism. The irreversible synth…
MCID: MC00002931
PMOID: PMO:00014569
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Citric Acid Cycle
Synonym: Citric Acid Cycles
Synonym: Citric acid cycle pathway
Synonym: Cycle, Citric Acid
Synonym: Cycle, Krebs
Synonym: Cycle, Tricarboxylic Acid
Synonym: Cycles, Citric Acid
Synonym: Cycles, Tricarboxylic Acid
Synonym: Krebs Cycle
Synonym: Krebs cycle
Tree Number: T4.7.3.20
database_cross_reference: AOD:0000001830
database_cross_reference: AOD:0000021641
database_cross_reference: CHV:0000003013
database_cross_reference: CSP:2983-8380
database_cross_reference: GO:GO:0006099
database_cross_reference: LCH_NW:sh85073260
database_cross_reference: MSH:D002952
database_cross_reference: NCI:C91329
database_cross_reference: NCI_BioC:C91329
database_cross_reference: SNMI:F-66040
database_cross_reference: SNOMEDCT_US:129911007
database_cross_reference: SNOMEDCT_US:88521006

Cofactors and Vitamins Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
MCID: MC00526270
PMOID: PMO:00014570
Subclass_of: Metabolic Pathway
Synonym: Metabolism of Cofactors and Vitamins - Reference Pathway
Tree Number: T4.7.4
database_cross_reference: NCI:C39733
database_cross_reference: NCI_KEGG:C39733

Biotin Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC00391578
PMOID: PMO:00014571
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Biotin Metabolism
Synonym: biotin metabolic process
Synonym: biotin metabolism
Synonym: vitamin B7 metabolic process
Synonym: vitamin B7 metabolism
Synonym: vitamin H metabolic process
Synonym: vitamin H metabolism
Tree Number: T4.7.4.1
database_cross_reference: GO:GO:0006768
database_cross_reference: NCI:C38790
database_cross_reference: NCI_KEGG:C38790

Folate Biosynthesis Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC00390389
PMOID: PMO:00014572
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Folate Biosynthesis
Synonym: folate biosynthesis
Synonym: folate biosynthetic process
Synonym: folic acid anabolism
Synonym: folic acid biosynthesis
Synonym: folic acid biosynthetic process
Synonym: folic acid formation
Synonym: folic acid synthesis
Synonym: vitamin B9 biosynthesis
Synonym: vitamin B9 biosynthetic process
Tree Number: T4.7.4.2
database_cross_reference: GO:GO:0046656
database_cross_reference: NCI:C38809
database_cross_reference: NCI_KEGG:C38809

Lipoic Acid Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC01394197
PMOID: PMO:00014573
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Lipoic acid metabolism
Tree Number: T4.7.4.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91420
database_cross_reference: NCI_KEGG:C91420

Nicotinate and Nicotinamide Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC01393971
PMOID: PMO:00014574
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Nicotinate and Nicotinamide Metabolism
Tree Number: T4.7.4.4
database_cross_reference: NCI:C38838
database_cross_reference: NCI_KEGG:C38838

One Carbon Pool by Folate Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC00527230
PMOID: PMO:00014575
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: One Carbon Pool by Folate
Tree Number: T4.7.4.5
database_cross_reference: NCI:C38842
database_cross_reference: NCI_KEGG:C38842

Pantothenate and CoA Biosynthesis Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC00527398
PMOID: PMO:00014576
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Pantothenate and CoA Biosynthesis
Tree Number: T4.7.4.6
database_cross_reference: NCI:C38844
database_cross_reference: NCI_KEGG:C38844

Porphyrin and Chlorophyll Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC00524841
PMOID: PMO:00014577
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Porphyrin and Chlorophyll Metabolism
Tree Number: T4.7.4.7
database_cross_reference: NCI:C38852
database_cross_reference: NCI_KEGG:C38852

Retinol Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC00452245
PMOID: PMO:00014578
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Retinol Metabolism
Synonym: retinol metabolic process
Synonym: retinol metabolism
Synonym: vitamin A1 alcohol metabolic process
Synonym: vitamin A1 alcohol metabolism
Synonym: vitamin A1 metabolic process
Synonym: vitamin A1 metabolism
Tree Number: T4.7.4.8
database_cross_reference: GO:GO:0042572
database_cross_reference: NCI:C38861
database_cross_reference: NCI_KEGG:C38861

Riboflavin Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC00392636
PMOID: PMO:00014579
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Riboflavin Metabolism
Synonym: riboflavin metabolic process
Synonym: riboflavin metabolism
Synonym: vitamin B2 metabolic process
Synonym: vitamin B2 metabolism
Synonym: vitamin G metabolic process
Synonym: vitamin G metabolism
Tree Number: T4.7.4.9
database_cross_reference: GO:GO:0006771
database_cross_reference: NCI:C38862
database_cross_reference: NCI_KEGG:C38862

Thiamine Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC00392635
PMOID: PMO:00014580
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Thiamin Metabolism
Synonym: Thiamin Metabolism Pathway
Synonym: Thiamine Metabolism
Synonym: thiamin metabolic process
Synonym: thiamin metabolism
Synonym: thiamine metabolic process
Synonym: thiamine metabolism
Synonym: vitamin B1 metabolic process
Synonym: vitamin B1 metabolism
Tree Number: T4.7.4.10
database_cross_reference: GO:GO:0006772
database_cross_reference: NCI:C38873
database_cross_reference: NCI_KEGG:C38873

Ubiquinone Biosynthesis Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
Definition: Ubiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from the shikimate pathway; 4-hydroxybenzoate is directly formed from chorismate in bacteria, while it can be formed from either chorismate or tyrosine in yeast. The following biosynthesis of terpenoid moiety involves reactions of prenylation, decarboxylation, and three hydroxylations alternating with three methylations. The order of these reactions are somewhat different between bacteria and yeast. Phylloquinone (vitamin K1), menaquinone (vitamin K2), and tocopherol (vitamin E) are fat-soluble vitamins. Phylloquinone is a compound present in all photosynthetic plants serving as a cofactor for photosystem I-mediated electron transport. Menaquinone is an obligatory component of the electron-transfer pathway in bacteria.
MCID: MC00390592
PMOID: PMO:00014581
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Ubiquinone Biosynthesis
Synonym: Ubiquinone and menaquinone biosynthesis
Synonym: Ubiquinone and other terpenoid-quinone biosynthesis
Synonym: coenzyme Q biosynthesis
Synonym: coenzyme Q biosynthetic process
Synonym: ubiquinone anabolism
Synonym: ubiquinone biosynthesis
Synonym: ubiquinone biosynthetic process
Synonym: ubiquinone formation
Synonym: ubiquinone synthesis
Tree Number: T4.7.4.11
database_cross_reference: GO:GO:0006744
database_cross_reference: NCI:C38880
database_cross_reference: NCI_KEGG:C38880

Vitamin B6 Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
MCID: MC00530765
PMOID: PMO:00014582
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Vitamin B6 Metabolism
Tree Number: T4.7.4.12
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38885
database_cross_reference: NCI_KEGG:C38885

Degradation Pathway
type: Class
subclass of: Metabolic Pathway
Definition: A sequence of biological or biochemical events that result in the catabolism of large molecules or polymers.
MCID: MC01393745
PMOID: PMO:00014583
Subclass_of: Metabolic Pathway
Synonym: Degradative Pathway
Tree Number: T4.7.5
database_cross_reference: NCI:C39702

Autophagy Regulation Pathway
type: Class
subclass of: Degradation Pathway
MCID: MC00697195
PMOID: PMO:00014584
Subclass_of: Degradation Pathway
Synonym: Regulation of autophagy
Synonym: regulation of autophagy
Tree Number: T4.7.5.1
database_cross_reference: GO:GO:0010506
database_cross_reference: NCI:C91430
database_cross_reference: NCI_KEGG:C91430

Biodegradation of Xenobiotics Pathway
type: Class
subclass of: Degradation Pathway
MCID: MC00523216
PMOID: PMO:00014585
Subclass_of: Degradation Pathway
Synonym: Biodegradation of Xenobiotics
Tree Number: T4.7.5.2
database_cross_reference: NCI:C39735
database_cross_reference: NCI_KEGG:C39735

Drug Metabolism by Cytochrome P450 Pathway
type: Class
subclass of: Biodegradation of Xenobiotics Pathway
MCID: MC01394170
PMOID: PMO:00014586
Subclass_of: Biodegradation of Xenobiotics Pathway
Synonym: Drug metabolism - cytochrome P450
Tree Number: T4.7.5.2.1
database_cross_reference: NCI:C91423
database_cross_reference: NCI_KEGG:C91423

Drug Metabolism by Non-CYP450 Enzymes Pathway
type: Class
subclass of: Biodegradation of Xenobiotics Pathway
MCID: MC01394173
PMOID: PMO:00014587
Subclass_of: Biodegradation of Xenobiotics Pathway
Synonym: Drug metabolism - other enzymes
Tree Number: T4.7.5.2.2
database_cross_reference: NCI:C91424
database_cross_reference: NCI_KEGG:C91424

Glucuronidation Pathway
type: Class
subclass of: Biodegradation of Xenobiotics Pathway
Definition: An inactivating and detoxification pathway for a variety of exogenous and endogenous molecules, including drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids and bile acids. Glucuronic acid is highly soluble in water and is often linked to poisonous substances to allow for subsequent elimination and to hormones to allow for easier transport. Also, drugs are commonly conjugated to glucuronic acid to allow for easier delivery. Excretion occurs via urine or bile.
MCID: MC01393890
PMOID: PMO:00014588
Subclass_of: Biodegradation of Xenobiotics Pathway
Synonym: Glucuronidation
Tree Number: T4.7.5.2.3
database_cross_reference: NCI:C63811

Metabolism of Xenobiotics by Cytochrome P450 Pathway
type: Class
subclass of: Biodegradation of Xenobiotics Pathway
MCID: MC01394201
PMOID: PMO:00014589
Subclass_of: Biodegradation of Xenobiotics Pathway
Synonym: Metabolism of xenobiotics by cytochrome P450
Tree Number: T4.7.5.2.4
database_cross_reference: NCI:C91422
database_cross_reference: NCI_KEGG:C91422

Cyclin E Degradation Pathway
type: Class
subclass of: Degradation Pathway
Definition: Cyclins are proteins that associate with cyclin-dependent protein kinases to regulate their activity and the progression of the cell cycle through specific checkpoints. The cyclical increase and decrease in cyclin levels is a key to cell cycle regulation. Disruption of cyclin action can lead to either cell cycle arrest, or to uncontrolled cell proliferation. When cyclin E is abundant it interacts with the cell cycle checkpoint kinase cdk2 to activate cdk2 and allow progression of the cell cycle from G1 to S phase. One of the key targets of activated cdk2 complexed with cyclin E is the tumor suppressor Rb. When dephosphorylated in G1, Rb complexes with and blocks transcriptional activation by E2F transcription factors. When Rb is phosphorylated by cdk2/Cyclin E, it dissociates from E2f, allowing E2F to activate the transcription of genes required for S phase. One of the genes activated by E2F is cyclin E itself, leading to a positive feedback cycle as cyclin E accumulates. The decision by the cell to either remain in G1 or progress into S phase is the result in part of the balance between cyclin E production and proteolytic degradation in the proteasome. Cyclin E is targeted for destruction by the proteasome through ubiquitination when associated with a complex of proteins called the SCF or F box complex. Proteins included this complex include an F box protein that targets specific substrates such as Cyclin E for degradation. In the case of cyclin E the F box protein Fbw7, also called hCdc4, associates with phosphorylated free cyclin E to recruit it into the SCF complex for degradation. SCFFbw7 is a ubiquitin ligase recruited into the complex that specifically targets cyclin E. Cul3, skp1, and Rbx1 also are part of the complex that degrades cyclin E. There may be redundancy for some components of the complex since cul1 deletion also disrupts cyclin E degradation, and multiple F box proteins may contribute to cyclin E degradation. The interaction of multiple different…
MCID: MC00523443
PMOID: PMO:00014590
Subclass_of: Degradation Pathway
Synonym: Cyclin E Destruction Pathway
Tree Number: T4.7.5.3
database_cross_reference: NCI:C39078
database_cross_reference: NCI_BioC:C39078

Dicer Pathway
type: Class
subclass of: Degradation Pathway
Definition: The degradation of endogenous mRNA in a sequence-specific manner can be induced by dsRNA [RNA interference (RNAi)], antisense transcription, or viral infection. In the current model for posttranscriptional gene silencing by RNAi, the ribonuclease III like enzyme Dicer processes dsRNA into small fragments (siRNA) of 21-25 nts. The siRNA is incorporated into the RNA-induced silencing complex (RISC), which targets and degrades the homologous mRNA. Most of the proteins in the RISC (with the exception of Ago2 and Dicer have not been identified) but likely contain endonuclease, helicase, exonuclease and homology scanning activity. (This definition may be outdated - see the DesignNote.)
MCID: MC00523634
PMOID: PMO:00014591
Subclass_of: Degradation Pathway
Tree Number: T4.7.5.4
database_cross_reference: NCI:C39050
database_cross_reference: NCI_BioC:C39050

E2F1 Degradation Pathway
type: Class
subclass of: Degradation Pathway
Definition: E2F-1 is a transcription factor that regulates the expression of genes involved in the cell cycle and that is involved in progression of the cell cycle from G1 into S phase. Over-expression of E2F-1 can induce cellular transformation and under-expression can repress apoptosis. Association with the tumor suppressor Rb represses E2F-1 activity, and this repression is relieved when the cdk2/cyclin E complex at the G1 to S phase transition phosphorylates Rb. Like many cell cycle regulators, E2F-1 is regulated through phosphorylation by a cyclin-dependent protein kinase, cdk2/cyclin A, and by proteolytic degradation. Phosphorylation of E2F-1 by cdk2/cyclin A leads to E2F-1 inactivation, blocking DNA binding. E2F-1 is also regulated through degradation in the proteasome at the S/G2 transition. The F box complex that degrades E2F-1 contains components shared with the complexes that target other cell cycle factors for degradation. The F box protein that specifically recruits E2F for ubiquitination and degradation is Skp2. Other components of the SCF complex include Skp1, Cul1, and cdc34. Skp2 expression is cyclical, increasing in the S/G2 transition as E2F-1 is degraded. Knowledge of E2F-1 activity and its regulation form part of the complex set of interactions regulating the cell cycle and potential targets for the treatment of cancer. (This definition may be outdated - see the DesignNote.)
MCID: MC00523734
PMOID: PMO:00014592
Subclass_of: Degradation Pathway
Synonym: E2F1 Destruction Pathway
Tree Number: T4.7.5.5
database_cross_reference: NCI:C39232
database_cross_reference: NCI_BioC:C39232

Endoplasmic Reticulum Degradation Pathway
type: Class
subclass of: Degradation Pathway
Definition: The endoplasmic reticulum (ER) of the cell operates a quality control system that identifies misfolded proteins, transports them into the cytoplasm and then targets them for degradation by the proteasome. Aberrant protein degradation is the mechanism underlying many diseases, including cystic fibrosis and heritable forms of lung and liver disease. The pathways that orchestrate the destruction of aberrant proteins are collectively termed ER-associated degradation (ERAD). Most of the proteins synthesized in the ER are cotranslationally modified with N (asparagine)-linked glycans by addition of triglycosylated, branched oligosaccharides at asparagines residues. Rapid glucose trimming by ER glucosidases generates monoglucosylated N-glycans (Glc0-3Man9GlcNAc2). Productive folding of the polypeptides to which the glycans are attached requires the services of an ER lectin chaperone called calnexin (CNX) that recognize the Glc1Man9GlcNAc2 oligosaccharide and assists the folding of newly synthesized glycoproteins. Because the half-time of monoglucose in the nascent glycoproteins is about 2 min, the protein should be repeatedly reglycosylated by UDP-glucose: glycoprotein glucosyltransferase (UGGT) resulting in association with CNX. Next, the mannose residue from the middle branch of the Man9GlcNAc2 oligosaccharide is removed by ER -mannosidase I, then correctly folded glycoproteins bearing Man8GlcNAc2 isomer B (Man8B form) are transported out of the ER to the Golgi apparatus. If the native structure of the glycoprotein cannot be achieved it is retained in the ER. When substrates are released from CNX by glucosidase II, they may be transferred to one of 2 pathways: EDEM for degradation or UUGT for reentry into CNX cycle. A glycoprotein with permanent structural defects is modified by the slow-acting enzyme ER mannosidase I. This enzyme attaches Man8 glycans to misfolded glycoproteins and in so doing generates a signal that results in ER-associated glycoprotein degradation (GER…
MCID: MC00523748
PMOID: PMO:00014593
Subclass_of: Degradation Pathway
Synonym: ER-associated degradation (ERAD) Pathway
Tree Number: T4.7.5.6
database_cross_reference: NCI:C39288
database_cross_reference: NCI_BioC:C39288

Glycoprotein Degradation Pathway
type: Class
subclass of: Degradation Pathway
MCID: MC00391255
PMOID: PMO:00014594
Subclass_of: Degradation Pathway
Synonym: Glycoprotein Degradation
Synonym: Other glycan degradation
Synonym: glycoprotein breakdown
Synonym: glycoprotein catabolic process
Synonym: glycoprotein catabolism
Synonym: glycoprotein degradation
Tree Number: T4.7.5.7
database_cross_reference: GO:GO:0006516
database_cross_reference: NCI:C38820
database_cross_reference: NCI_KEGG:C38820

Limonene and Pinene Degradation Pathway
type: Class
subclass of: Degradation Pathway
MCID: MC01394200
PMOID: PMO:00014595
Subclass_of: Degradation Pathway
Synonym: Limonene and pinene degradation
Tree Number: T4.7.5.8
database_cross_reference: NCI:C91421
database_cross_reference: NCI_KEGG:C91421

Lysosome Assembly Pathway
type: Class
subclass of: Degradation Pathway
Definition: Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
MCID: MC01394095
PMOID: PMO:00014596
Subclass_of: Degradation Pathway
Synonym: Lysosome
Tree Number: T4.7.5.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91440
database_cross_reference: NCI_KEGG:C91440

Proteasome Pathway
type: Class
subclass of: Degradation Pathway
Definition: The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.
MCID: MC00591172
PMOID: PMO:00014597
Subclass_of: Degradation Pathway
Synonym: Proteasome
Synonym: proteasome pathway
Tree Number: T4.7.5.10
database_cross_reference: GO:GO:0043161
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91521
database_cross_reference: NCI_KEGG:C91521

RAR and RXR Degradation Pathway
type: Class
subclass of: Degradation Pathway
Definition: Once retinoids are bound by the RAR/RXR heterodimer they became transcriptional activated. As a consequence they are degraded by the proteasome. Phosphorylation in the activation domain one (AF1) and presence of the activation domain 2 (AF2) trigger the ubiquitination of the receptors. Moreover, heterodimerization of RAR and RXR accelerate degradation of the receptors. (This definition may be outdated - see the DesignNote.)
MCID: MC00525058
PMOID: PMO:00014598
Subclass_of: Degradation Pathway
Synonym: Degradation of the RAR and RXR by the proteasome
Tree Number: T4.7.5.11
database_cross_reference: NCI:C39215
database_cross_reference: NCI_BioC:C39215

Ubiquitin-Proteasomal Pathway
type: Class
subclass of: Degradation Pathway
Definition: The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examination of these neurons in diseased tissue has revealed the presence of Lewy bodies, dense aggregates that include the protein alpha-synuclein. A genetic basis for most cases of Parkinson's disease has not yet been identified, but mutations in alpha-synuclein have been associated with at least one rare form of the disease, and mutations in another protein, the parkin gene, are associated with another inherited form of Parkinson's disease. Parkin is found in Lewy bodies along with alpha-synuclein and the parkin protein is an E3 ubiquitin ligase. Parkin appears to work in conjunction with ubiquitin activating (Uba)1, an E1 protein and the ubiquitin-conjugating (Ubc) enzymes UbcH7 and 8. The E1 delivers ubiquitin to the E2 in a cycle that creates an increasing chain of ubiquitin. The Parkin E3 ligates this onto substrates and so tags these proteins in normal cells, targeting them for destruction in the proteasome. One of the proteins that parkin normally targets for destruction is a specific O-glycosylated form of alpha-synuclein. Failure of parkin-mediated degradation of alpha-synuclein may be a key factor leading to the death of dopaminergic neurons. Another substrate of parkin is a GPCR-like protein called Pael-R that accumulates in the ER of affected cells and may cause neuronal cell death. The involvement of Parkin and alpha-synuclein mutations in genetic forms of Parkinson's suggests that failure of ubiquitination and protein degradation may be causative in other forms of Parkinson's. Questions remaining include the cause of the lack of effective ubiquitination in individuals lacking obvious genetic defects in this pathway and how to use this knowledge of ubiquitination and protein degradation in Parkinson's disease to identify therapeutic strategies. (This definition may be outdated - see the DesignNote.)
MCID: MC00527799
PMOID: PMO:00014599
Subclass_of: Degradation Pathway
Synonym: Role of Parkin in the Ubiquitin-Proteasomal Pathway
Tree Number: T4.7.5.12
database_cross_reference: NCI:C39182
database_cross_reference: NCI_BioC:C39182

Endocytosis Pathway
type: Class
subclass of: Metabolic Pathway
Definition: Endocytosis is a mechanism for cells to remove ligands, nutrients, plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
MCID: MC01394337
PMOID: PMO:00014600
Subclass_of: Metabolic Pathway
Synonym: Endocytosis
Tree Number: T4.7.6
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91473
database_cross_reference: NCI_KEGG:C91473

Energy Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
MCID: MC00526352
PMOID: PMO:00014601
Subclass_of: Metabolic Pathway
Synonym: Energy Metabolism - Reference Pathway
Tree Number: T4.7.7
database_cross_reference: NCI:C39727
database_cross_reference: NCI_KEGG:C39727

Acetyl Group Shuttle Pathway
type: Class
subclass of: Energy Metabolism Pathway
Definition: Acetyl-CoA is produced in mitochondria through the metabolism of fatty acids and the oxidation of pyruvate to acetyl-CoA. When ATP is needed, this acetyl-CoA can enter the Krebs cycle to drive oxidative phosphorylation. When ATP supplies are abundant, the acetyl-CoA can be diverted to other purposes like energy storage in the form of fatty acids. The biosynthesis of fatty acids from this acetyl-CoA cannot take place directly however, since it is produced inside mitochondria while fatty acid biosynthesis occurs in the cytosol. Also, there is not a mechanism that directly transports acetyl-CoA out of mitochondria. To be transported, the acetyl-CoA must be chemically converted to citric acid using a pathway called the tricarboxylate transport system. Inside mitochondria, the enzyme citrate synthase joins acetyl-CoA with oxaloacetate to make citrate. This citrate is transported from the mitochondria to the cytosol, thus transporting the acetyl-CoA in the form of citrate. Once in the cytosol, the citrate is converted back to oxaloacetate, which is then reduced to malate. Malate can be oxidized to pyruvate by the malic enzyme, with production of NADPH as well, that can contribute to fatty acid biosynthesis. Pyruvate can be reimported back into the mitochondria. Alternatively, malate can be transported itself back into the mitochondria and used to produce NADH once inside mitochondria. (This definition may be outdated - see the DesignNote.)
MCID: MC00523003
PMOID: PMO:00014602
Subclass_of: Energy Metabolism Pathway
Synonym: Shuttle for transfer of acetyl groups from mitochondria to the cytosol
Tree Number: T4.7.7.1
database_cross_reference: NCI:C39144
database_cross_reference: NCI_BioC:C39144

ATP Synthesis Pathway
type: Class
subclass of: Energy Metabolism Pathway
MCID: MC01393938
PMOID: PMO:00014603
Subclass_of: Energy Metabolism Pathway
Synonym: ATP Synthesis
Tree Number: T4.7.7.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38787
database_cross_reference: NCI_KEGG:C38787

Electron Transport Pathway
type: Class
subclass of: Energy Metabolism Pathway
Definition: The body gets energy through the oxidation of food such as glucose and fatty acids. The chemical energy contained in these foods is extracted and converted until it reaches a common form, the high-energy phosphate bonds of ATP. The hydrolysis of ATP is highly favorable and is coupled to a variety of energetically unfavorable processes to drive them forward. Most of the energy of glucose or fatty acids is extracted through oxidation to produce the reduced high-energy electron carriers NADH and FADH2. From there, the energy is transferred next to the electron transport system associated with the mitochondrial inner membrane. This chain includes a series of protein complexes and non-membrane cofactors that transfer the electrons from NADH and FADH2 in a series of redox reactions from carrier to carrier. Oxygen is the final electron acceptor at the end of the chain, resulting in the production of water. The oxygen we breathe, and which is transported by hemoglobin in the blood to all of the tissues, serves this purpose and allows electron transport to occur. As the electrons pass through the chain, they transfer their energy to the complexes, which use the energy to pump protons out of the mitochondrial matrix, creating a proton gradient across the inner mitochondrial membrane. The chemical energy that started with glucose, and was transferred to NADH and FADH2, is then converted to the energy of a concentration gradient. The inner mitochondrial membrane is impermeable to protons on its own, so the energy of the proton gradient is stable, waiting to be recaptured. The energy is recaptured by ATP synthase in the inner mitochondrial membrane. This enzyme allows protons to flow back down their concentration gradient across the membrane, and in the process uses the energy of the gradient to drive ATP synthesis. The movement of the electrons through electron transport, the proton gradient and ATP synthesis are all coupled processes that require each other to occur. The cell …
MCID: MC00526303
PMOID: PMO:00014604
Subclass_of: Energy Metabolism Pathway
Synonym: Electron Transport Reaction in Mitochondria
Tree Number: T4.7.7.3
database_cross_reference: NCI:C39074
database_cross_reference: NCI_BioC:C39074

Feeding Amino Groups into the Urea Cycle
type: Class
subclass of: Energy Metabolism Pathway
Definition: Excess amino acids in the body can be used as a source of energy, with their carbon skeleton converted to metabolic intermediates such as acetyl-CoA or intermediates in the Krebs cycle. The metabolic breakdown of amino acids releases nitrogen that must be converted to a relatively non-toxic form and then excreted. In mammals, the nitrogen is converted to urea in the liver through a series of reactions called the urea cycle. The ammonia released through the deamination of amino acids is reacted to produce carbamoyl phosphate, a reaction catalyzed by carbamoyl phosphate synthase. The enzyme ornithine transcarbamoylase is found in mitochondria and converts ornithine into citrulline. Citrulline is exported into the cytoplasm where another nitrogen for urea is acquired from aspartate, followed by the release of fumarate to form the amino acid arginine. Urea is released from arginine by the enzyme arginase, bringing the cycle back around to ornithine. The general route of entry for amino acids into the urea cycle is through transamination, the transfer of their amino group to alpha-ketoglutarate to form glutamate. The amino group from glutamate is released by glutamate dehydrogenase to create an ammonium ion. The ammonium ion is used to make carbamoyl phosphate, and ultimately urea through the urea cycle. Different amino acids can enter this pathway by different routes. The transfer of the amino group from aspartate to alpha-ketobutyrate creates oxaloacetate, a Krebs cycle intermediate. Alanine goes through transamination to release pyruvate, which can be used as fuel. Genetic defects that completely block the urea cycle are not observed in people, perhaps since such a defect would be fatal. Mutations that reduce the activity of the urea cycle have been observed, with serious affects on mental functioning and other toxicities caused by elevated levels of ammonia. (This definition may be outdated - see the DesignNote.)
MCID: MC01394354
PMOID: PMO:00014605
Subclass_of: Energy Metabolism Pathway
Synonym: The reactions that feed amino groups into the urea cycle
Tree Number: T4.7.7.4
database_cross_reference: NCI:C91330
database_cross_reference: NCI_BioC:C91330

Malate-Aspartate Shuttle Pathway
type: Class
subclass of: Energy Metabolism Pathway
Definition: Most of the energy derived from the oxidation of glucose is not extracted directly as ATP, but as reduced NADH that transfers high-energy electrons to the electron transport chain in the inner mitochondrial membrane. This NADH comes primarily from the Krebs cycle in the mitochondrial matrix and is therefore directly accessible to electron transport. NADH generated during glycolysis cannot reach the electron transport chain directly however and there is no direct mechanism for the transfer of NADH across the mitochondrial membrane. Instead shuttle mechanisms have evolved to move the energy of reduced NADH across the membrane in the form of other reduced molecules. One shuttle is the glycerophosphate shuttle and another is the malate-aspartate shuttle. The malate-aspartate shuttle occurs in mammalian tissues. First, oxaloacetate on the cytoplasmic side is reduced by NADH, creating malate and NAD+. Malate and the electrons it carries are transported into the mitochondria across the inner mitochondrial membrane, in exchange for alpha-ketoglutarate, which is transported out of the mitochondria. Once inside, the energy in malate is extracted again by reducing NAD+ to make NADH, regenerating oxaloacetate. This NADH is then free to transfer its high energy electrons to the electron transport chain. The oxaloacetate is transaminated with glutamate to make aspartate and alpha-ketoglutarate. Aspartate is returned to the cytosol by the aspartate-glutamate transporter, which moves glutamate into the mitochondria as it transports aspartate out. The overall result is that NADH is transported into the mitochondria, and can be used to generate 3 ATP per every NADH transported in from the cytosol, a very efficient process. (This definition may be outdated - see the DesignNote.)
MCID: MC00527055
PMOID: PMO:00014606
Subclass_of: Energy Metabolism Pathway
Synonym: Malate-aspartate shuttle
Synonym: malate aspartate shuttle
Synonym: malate-aspartate shuttle
Synonym: malate/aspartate shuttle
Synonym: malate:aspartate shuttle
Tree Number: T4.7.7.5
database_cross_reference: GO:GO:0043490
database_cross_reference: NCI:C39143
database_cross_reference: NCI_BioC:C39143

Methane Metabolism Pathway
type: Class
subclass of: Energy Metabolism Pathway
MCID: MC00392057
PMOID: PMO:00014607
Subclass_of: Energy Metabolism Pathway
Synonym: Methane Metabolism
Synonym: methane metabolic process
Synonym: methane metabolism
Tree Number: T4.7.7.6
database_cross_reference: GO:GO:0015947
database_cross_reference: NCI:C38835
database_cross_reference: NCI_KEGG:C38835

Nitrogen Metabolism Pathway
type: Class
subclass of: Energy Metabolism Pathway
MCID: MC00182897
PMOID: PMO:00014608
Subclass_of: Energy Metabolism Pathway
Synonym: Nitrogen Metabolism
Synonym: nitrogen metabolism
Tree Number: T4.7.7.7
database_cross_reference: CHV:0000041667
database_cross_reference: CSP:2078-3277
database_cross_reference: NCI:C38839
database_cross_reference: NCI_KEGG:C38839

Oxidative Phosphorylation Pathway
type: Class
subclass of: Energy Metabolism Pathway
MCID: MC00009565
PMOID: PMO:00014609
Subclass_of: Energy Metabolism Pathway
Synonym: ATP biosynthesis (oxidative)
Synonym: ATP cycle
Synonym: OX PHOS
Synonym: Oxidative Phosphorylation
Synonym: Oxidative Phosphorylations
Synonym: Oxidative phosphorylation
Synonym: Oxidative phosphorylation (function)
Synonym: Oxidative phosphorylation, function
Synonym: Oxidative phosphorylation, function (observable entity)
Synonym: PHOS OX
Tree Number: T4.7.7.8
database_cross_reference: AOD:0000001831
database_cross_reference: AOD:0000021642
database_cross_reference: CHV:0000009145
database_cross_reference: CSP:2304-1959
database_cross_reference: GO:GO:0006119
database_cross_reference: MSH:D010085
database_cross_reference: NCI:C38843
database_cross_reference: NCI_KEGG:C38843
database_cross_reference: SNMI:F-60320
database_cross_reference: SNOMEDCT_US:5410007

Sulfur Metabolism Pathway
type: Class
subclass of: Energy Metabolism Pathway
MCID: MC00392606
PMOID: PMO:00014610
Subclass_of: Energy Metabolism Pathway
Synonym: Sulfur Metabolism
Synonym: sulfur compound metabolic process
Synonym: sulfur metabolism
Synonym: sulphur metabolic process
Synonym: sulphur metabolism
Tree Number: T4.7.7.9
database_cross_reference: GO:GO:0006790
database_cross_reference: NCI:C38869
database_cross_reference: NCI_KEGG:C38869

Glycan Biosynthesis and Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
MCID: MC00523811
PMOID: PMO:00014611
Subclass_of: Metabolic Pathway
Synonym: Glycan Biosynthesis and Metabolism - Reference Pathway
Tree Number: T4.7.8
database_cross_reference: NCI:C39732
database_cross_reference: NCI_KEGG:C39732

Blood Group Glycolipid Biosynthesis - Lacto and Neolacto Series Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
MCID: MC01393851
PMOID: PMO:00014612
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Blood Group Glycolipid Biosynthesis - Lact Series
Synonym: Blood Group Glycolipid Biosynthesis - Neolact Series
Synonym: Glycosphingolipid biosynthesis - lacto and neolacto series
Tree Number: T4.7.8.1
database_cross_reference: NCI:C38791
database_cross_reference: NCI_KEGG:C38791

Ganglioside Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
MCID: MC00390708
PMOID: PMO:00014613
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Ganglioside Biosynthesis
Synonym: ganglioside anabolism
Synonym: ganglioside biosynthesis
Synonym: ganglioside biosynthetic process
Synonym: ganglioside formation
Synonym: ganglioside synthesis
Tree Number: T4.7.8.2
database_cross_reference: GO:GO:0001574
database_cross_reference: NCI:C38812
database_cross_reference: NCI_KEGG:C38812

Globoside Metabolism Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
MCID: MC00391665
PMOID: PMO:00014614
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Globoside Metabolism
Synonym: globoside metabolic process
Synonym: globoside metabolism
Tree Number: T4.7.8.3
database_cross_reference: GO:GO:0001575
database_cross_reference: NCI:C38813
database_cross_reference: NCI_KEGG:C38813

Glycosaminoglycan Biosynthesis Pathway - Chondroitin Sulfate
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
Definition: Glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide units and form proteoglycans by covalently attaching to their core proteins. Chondroitin sulfate (CS) is a glycosaminoglycan with the disaccharide unit GalNAc(b1-4)GlcA(b1-3), modified with ester-linked sulfate at certain positions. Dermatan sulfate (DS) is a modified form of CS, in which a portion of D-glucuronate residues is epimerized to L-iduronates. CS and DS are linked to serine residues in core proteins via a linkage tetrasaccharide formed by the transfer of xylose and three more residues. The assembly process of CS is initiated by the transfer of N-acetylgalactosamine to the linkage tetrasaccharide. The polymerization step is catalyzed by bifunctional enzymes (chondroitin synthases) that have both b-3 glucuronosyltransferase and b1-4 N-acetylgalactosaminyltransferase activities. Chondroitin polymerization also requires the action of the chondroitin polymerizing factor. Sulfation of chondroitin in vertebrates is a complex process, with multiple sulfotransferases involved in 4-O sulfation and 6-O sulfation of N-acetylgalactosamine residues. Additional enzymes exist for epimerization of glucuronic acid to iduronic acid in DS, sulfation at the C-2 position of the uronic acids, and other patterns of sulfation found in unusual species of chondroitin.
MCID: MC00526203
PMOID: PMO:00014615
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Chondroitin / Heparan Sulfate Biosynthesis
Synonym: Chondroitin/Heparan Sulfate Biosynthesis Pathway
Synonym: Glycosaminoglycan Biosynthesis - Chondroitin Sulfate
Tree Number: T4.7.8.4
database_cross_reference: NCI:C38795
database_cross_reference: NCI_KEGG:C38795

Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
MCID: MC01394182
PMOID: PMO:00014616
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Glycosaminoglycan biosynthesis - heparan sulfate
Synonym: Heparan Sulfate Biosynthesis Pathway
Tree Number: T4.7.8.5
database_cross_reference: NCI:C91414
database_cross_reference: NCI_KEGG:C91414

Glycosaminoglycan Biosynthesis Pathway - Keratan Sulfate
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
Definition: Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
MCID: MC00390257
PMOID: PMO:00014617
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Glycosaminoglycan Biosynthesis - Keratan Sulfate
Synonym: Keratan Sulfate Biosynthesis
Synonym: Keratan Sulfate Biosynthesis Pathway
Synonym: keratan sulfate anabolism
Synonym: keratan sulfate biosynthesis
Synonym: keratan sulfate biosynthetic process
Synonym: keratan sulfate formation
Synonym: keratan sulfate synthesis
Synonym: keratan sulphate biosynthesis
Synonym: keratan sulphate biosynthetic process
Tree Number: T4.7.8.6
database_cross_reference: GO:GO:0018146
database_cross_reference: NCI:C38830
database_cross_reference: NCI_KEGG:C38830

Glycosaminoglycan Degradation Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
MCID: MC01394014
PMOID: PMO:00014618
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Glycosaminoglycan Degradation
Tree Number: T4.7.8.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38821
database_cross_reference: NCI_KEGG:C38821

Glycosylation of N-linked Oligosaccarides Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
Definition: The biosynthesis pathway of N-glycans is a costly system with respect to the number of enzymes that are involved in the synthesis and trimming of N-glycans. While the structural diversity of N-glycans in mature proteins in the cell surface is introduced by glycosyltransferases in the Golgi complex, the core glycans in the ER are universal from yeast to mammal and have been considered as intermediates. (This definition may be outdated - see the DesignNote.)
MCID: MC00523825
PMOID: PMO:00014619
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Steps in the Glycosylation of Mammalian N-linked Oligosaccarides
Tree Number: T4.7.8.8
database_cross_reference: NCI:C38984
database_cross_reference: NCI_BioC:C38984

Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
Definition: Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis genes result in a genetic disorder, paroxysmal nocturnal hemoglobinuria.
MCID: MC00523826
PMOID: PMO:00014620
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: GPI-Anchor Biosynthesis Pathway
Synonym: Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis
Tree Number: T4.7.8.9
database_cross_reference: NCI:C38822
database_cross_reference: NCI_KEGG:C38822

Lipopolysaccharide Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
MCID: MC00390556
PMOID: PMO:00014621
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: LPS biosynthetic process
Synonym: Lipopolysaccharide Biosynthesis
Synonym: lipopolysaccharide anabolism
Synonym: lipopolysaccharide biosynthesis
Synonym: lipopolysaccharide biosynthetic process
Synonym: lipopolysaccharide formation
Synonym: lipopolysaccharide synthesis
Tree Number: T4.7.8.10
database_cross_reference: GO:GO:0009103
database_cross_reference: NCI:C38831
database_cross_reference: NCI_KEGG:C38831

N-Glycan Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
Definition: N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1-Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1-PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases, the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation.
MCID: MC00182701
PMOID: PMO:00014622
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Glycoprotein Biosynthesis
Synonym: Glycoprotein Biosynthesis Pathway
Synonym: N-Glycan Biosynthesis
Synonym: N-glycan biosynthesis
Tree Number: T4.7.8.11
database_cross_reference: GO:GO:0006487
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38819
database_cross_reference: NCI_KEGG:C38819

O-Glycan Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
Definition: O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
MCID: MC00527212
PMOID: PMO:00014623
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: O-Glycan Biosynthesis
Tree Number: T4.7.8.12
database_cross_reference: NCI:C38841
database_cross_reference: NCI_KEGG:C38841

O-Mannosyl Glycan Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
MCID: MC01393789
PMOID: PMO:00014624
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: O-Mannosyl glycan biosynthesis
Tree Number: T4.7.8.13
database_cross_reference: NCI:C91412
database_cross_reference: NCI_KEGG:C91412

Lipid Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
MCID: MC00526902
PMOID: PMO:00014625
Subclass_of: Metabolic Pathway
Synonym: Lipid Metabolism
Synonym: Lipid Metabolism - Reference Pathway
Synonym: Lipid Metabolism Reference Pathway
Tree Number: T4.7.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39728
database_cross_reference: NCI_KEGG:C39728

alpha-Linolenic Acid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00815362
PMOID: PMO:00014626
Subclass_of: Lipid Metabolism Pathway
Synonym: ALA metabolism
Synonym: alpha-Linolenic acid metabolism
Synonym: alpha-linolenic acid metabolic process
Synonym: alpha-linolenic acid metabolism
Tree Number: T4.7.9.1
database_cross_reference: GO:GO:0036109
database_cross_reference: NCI:C91418
database_cross_reference: NCI_KEGG:C91418

Anandamide Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: The lipid anandamide derived from arachidonic acid binds to the cannabinoid G-protein coupled receptors CB-1 and CB-2 to exert its biological effects. The CB-1 receptor is also the site of action of the psychoactive components of marijuana, including tetrahydrocannabinol (THC), and responsible for the effects of cannabinoids to repress learning, memory, and anxiety, relieve pain and nausea, and to stimulate appetite. The CB-2 receptor is expressed mainly in cells of the immune system and appears to modulate immune functions, but not to be involved in the effects of cannabinoids in the central nervous system. In addition to the illicit use of cannabinoids as drugs of abuse, the pharmaceutical use of natural and synthetic cannabinoids is being intensely studied, including a possible role in neurodegenerative diseases. Another therapeutic approach is the pharmacological modulation of levels of the endogenous cannabinoid anandamide. Although the subject of some controversy, the most likely route for the biosynthesis of anandamide starts with the formation of phosphatidylethanolamine from arachidonic acid and ethanolamine. Phosphatidylethanolamine is converted by N-acyltransferase to the phospholipid N-arachidonoyl-phosphatidylethanolamine (NAPE) and hydrolysis by phospholipase D releases phosphatidic acid and anandamide, which binds to the cannabinoid receptors. The signal it induces is terminated in part by degradation of anandamide by anandamide hydrolase (FAAH). 2-arachidonoyl-glycerol (2-AG) and 2-arachidonoyl glyceryl ether have also been shown to bind the cannabinoid receptors, and has been suggested to be important endocannabinoids. Also complicating cannabinoid pharmacology is the suggestion that some effects of cannabinoids might be moderated by additional receptor subtypes that have not yet been identified or by the vanilloid receptors. (This definition may be outdated - see the DesignNote.)
MCID: MC00525930
PMOID: PMO:00014627
Subclass_of: Lipid Metabolism Pathway
Synonym: Metabolism of Anandamide, an Endogenous Cannabinoid
Tree Number: T4.7.9.2
database_cross_reference: NCI:C39015
database_cross_reference: NCI_BioC:C39015

Arachidonic Acid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00391611
PMOID: PMO:00014628
Subclass_of: Lipid Metabolism Pathway
Synonym: arachidonic acid metabolic process
Synonym: arachidonic acid metabolism
Tree Number: T4.7.9.3
database_cross_reference: GO:GO:0019369
database_cross_reference: MTH:NOCODE

Beta-Oxidation of Fatty Acids Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: Fatty acids provide highly efficient energy storage, storing much more energy for their weight than carbohydrates like glucose. Fatty acids are stored as triglycerides in adipose tissue, in which each triglyceride molecule contains three fatty acids and one glycerol. Triglycerides form fatty droplets that exclude water and take up minimal space. Fatty acids are also more highly reduced than carbohydrates, so they provide more energy during oxidation. The efficiency of energy storage in fats is probably an important reason why animals store most of their energy as fats and only a small amount of energy as carbohydrates. When glucose levels are low during long periods between meals the enzyme glucagon secreted by the pancreas stimulates adipose lipase activity to release fatty acids from triglycerides. Epinephrine can stimulate the same activity to release energy during the fight or flight response. Once released, these fatty acids travel through the blood to other tissues such as muscle where they are oxidized to provide energy through the mitochondrial beta-oxidation pathway. Since fatty acid beta-oxidation occurs in the mitochondrial matrix, long-chain fatty acids must be actively transported from the cytoplasm into mitochondria by carnitine palmitoyltransferase. The chemical energy contained in fatty acids is released through the beta-oxidation of fatty acids in mitochondria. The beta-oxidation pathway includes four reactions that occur in repeating cycles with each fatty acid molecule. In each cycle, a fatty acid is progressively shortened by two carbons as it is oxidized and its energy captured by the reduced energy carriers NADH and FADH2. At the end of each cycle of four reactions, one acetyl-CoA two-carbon unit is released from the end of the fatty acid, which then goes through another round of beta-oxidation, continuing to oxidize and shorten even-chain fatty acids until they are entirely converted to acetyl-CoA. Fatty acids with an odd number of carbons in …
MCID: MC01394293
PMOID: PMO:00014629
Subclass_of: Lipid Metabolism Pathway
Synonym: Beta-Oxidation of Fatty Acids
Tree Number: T4.7.9.4
database_cross_reference: NCI:C91312
database_cross_reference: NCI_BioC:C91312

Bile Acid Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine.
MCID: MC00390743
PMOID: PMO:00014630
Subclass_of: Lipid Metabolism Pathway
Synonym: Bile Acid Biosynthesis
Synonym: Primary bile acid biosynthesis
Synonym: bile acid anabolism
Synonym: bile acid biosynthesis
Synonym: bile acid biosynthetic process
Synonym: bile acid formation
Synonym: bile acid synthesis
Tree Number: T4.7.9.5
database_cross_reference: GO:GO:0006699
database_cross_reference: NCI:C38789
database_cross_reference: NCI_KEGG:C38789

Biosynthesis of Unsaturated Fatty Acids Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC01394175
PMOID: PMO:00014631
Subclass_of: Lipid Metabolism Pathway
Synonym: Biosynthesis of unsaturated fatty acids
Tree Number: T4.7.9.6
database_cross_reference: NCI:C91425
database_cross_reference: NCI_KEGG:C91425

Eicosanoid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: The eicosanoids are a family of lipophilic hormones derived from the twenty carbon fatty acid arachidonic acid. Although they are diverse in structure, many eicosanoids have roles in inflammation, including regulation of vasodilation, vascular permeability, pain, and recruitment of leukocytes. Most members of this family are rapidly metabolized near their site of synthesis, so they act locally on neighboring cells, not distant parts of the body. They are also not stored in cells, but synthesized rapidly in response to stimuli, making regulation of their synthesis a key to their activity. Many drugs act through modulating the production of eicosanoids or modulating their signaling pathways. Hormones in the eicosanoid family include the prostaglandins, thromboxanes, leukotrienes, and prostacyclins. The first step in the production of eicosanoids is the release of arachidonic acid from either diacylglycerol or phospholipids by membrane bound phospholipases in response to extracellular stimulus. Arachidonic acid has several possible fates, including oxygenation by lipoxygenases to make HPETEs (hydroperoxyeicosatetraenoic acids), or production of prostaglandin H2 by PGH2 synthase. 5-lipoxygenase acts with the membrane bound protein FLAP (five lipoxygenase activating protein) to produce the epoxide leukotriene LTA4 which is hydrolyzed to produce LTB4 or has glutathione added by a glutathione S-transferase to produce LTC4 and LTD4. A G-protein coupled receptor for LTD4, CysLT1, mediates an important component of the inflammatory response of leukotrienes on airway constriction and recruitment of leukocytes, and several marketed asthma drugs act as antagonists of the CysLT1 receptor. PGH2 synthase actually consists of two enzyme components, a cyclooxygenase and a peroxidase, and there are more than one type of cyclooxygenase, including Cox-1 and Cox-2. Recent NSAIDS acting selectively as Cox-2 inhibitors like Vioxx are widely used for the treatment of arthritis and other inf…
MCID: MC00182642
PMOID: PMO:00014632
Subclass_of: Lipid Metabolism Pathway
Synonym: arachidonic metabolism
Synonym: eicosanoid metabolic process
Synonym: eicosanoid metabolism
Synonym: icosanoid metabolic process
Synonym: icosanoid metabolism
Tree Number: T4.7.9.7
database_cross_reference: CSP:1130-3736
database_cross_reference: GO:GO:0006690
database_cross_reference: MTH:NOCODE

Ether Lipid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC01394189
PMOID: PMO:00014633
Subclass_of: Lipid Metabolism Pathway
Synonym: Ether lipid metabolism
Tree Number: T4.7.9.8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91416
database_cross_reference: NCI_KEGG:C91416

Fatty Acid Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC01393847
PMOID: PMO:00014634
Subclass_of: Lipid Metabolism Pathway
Synonym: Fatty Acid Biosynthesis (path 2)
Synonym: Fatty acid biosynthesis
Tree Number: T4.7.9.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38806
database_cross_reference: NCI_KEGG:C38806

Fatty Acid Elongation Pathway in Mitochondria
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC01393849
PMOID: PMO:00014635
Subclass_of: Lipid Metabolism Pathway
Synonym: Fatty Acid Biosynthesis (path 1)
Synonym: Fatty acid elongation in mitochondria
Tree Number: T4.7.9.10
database_cross_reference: NCI:C38805
database_cross_reference: NCI_KEGG:C38805

Fatty Acid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00182671
PMOID: PMO:00014636
Subclass_of: Lipid Metabolism Pathway
Synonym: Fatty Acid Metabolism
Synonym: acid fatty metabolism
Synonym: acids fatty metabolism
Synonym: fatty acid metabolic process
Synonym: fatty acid metabolism
Tree Number: T4.7.9.11
database_cross_reference: CHV:0000041575
database_cross_reference: CSP:1130-3456
database_cross_reference: GO:GO:0006631
database_cross_reference: NCI:C26565
database_cross_reference: NCI:C38807
database_cross_reference: NCI_KEGG:C38807

Glycerolipid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00391630
PMOID: PMO:00014637
Subclass_of: Lipid Metabolism Pathway
Synonym: Glycerolipid Metabolism
Synonym: glycerolipid metabolic process
Synonym: glycerolipid metabolism
Tree Number: T4.7.9.12
database_cross_reference: GO:GO:0046486
database_cross_reference: NCI:C38816
database_cross_reference: NCI_KEGG:C38816

Glycerophospholipid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC01394186
PMOID: PMO:00014638
Subclass_of: Lipid Metabolism Pathway
Synonym: Glycerophospholipid metabolism
Tree Number: T4.7.9.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91415
database_cross_reference: NCI_KEGG:C91415

Linoleic Acid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00596540
PMOID: PMO:00014639
Subclass_of: Lipid Metabolism Pathway
Synonym: Linoleic acid metabolism
Synonym: linoleic acid metabolic process
Synonym: linoleic acid metabolism
Tree Number: T4.7.9.14
database_cross_reference: GO:GO:0043651
database_cross_reference: NCI:C91417
database_cross_reference: NCI_KEGG:C91417

Lipid Metabolism and Toxicity Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: Nuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. However, further studies have led to the identification of lipid ligands for some of these receptors, which are responsible for lipid metabolism, storage, and elimination. One of the characteristics of these receptors is that they act by forming heterodimers with retinoid X receptor (RXR). The receptors include peroxisome proliferators-Activated receptors (PPARs) for fatty acids, liver X receptor (LCR) for oxysterols, Farnesoid X receptors (FXR) for bile acids, and steroid xenobiotic receptor/X receptor (SXR/PXR or Nsil2) for xenobiotics. Other orphan receptors also requiring RXR for its functions are vitamin D receptor (VDR) for vitamin D and retinoic acid receptor (RAR) for retinoid acids, although these receptors are not involved in lipid metabolism. Upon binding to various ligands, three classes of proteins are synthesized including lipid binding proteins, the ATP-binding cassette (ABC) transporters and cytochrome P450 member proteins which catalyze lipid anabolism, metabolism, and elimination. In addition to lipid metabolism, some members of the cytochrome P450 family genes are responsible for activation of procarcinogens, detoxification of environmental toxins, and metabolism of drugs and xenobiotics. In particular, CAR, Nsil2, and recently identified VDR are important in up-regulation of these cytochromes. Of all the human cytochrome P450 genes, only a few CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 account for most toxicity effects, specifically CYP3A is responsible for clearing approximately half of the clinically prescribed drugs. For instance, acetaminophen, one of the most commonly used drug, is toxic in high doses due to the activation of CAR and the drug's subsequent conversion to acetyl-p-benzoquinone imine (NAPQI) by CYP1A2, CYP2E1 and CYP3A. (This …
MCID: MC00526901
PMOID: PMO:00014640
Subclass_of: Lipid Metabolism Pathway
Synonym: Nuclear Receptors in Lipid Metabolism and Toxicity
Tree Number: T4.7.9.15
database_cross_reference: NCI:C39174
database_cross_reference: NCI_BioC:C39174

Lipid Synthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: Sterol-regulatory element binding proteins (SREBPs) play a key role in transcriptional regulation of cholesterol metabolism in response to cholesterol levels in the cell. When cholesterol is abundant in the cell, the SREBPs are retained in the ER. When cholesterol levels decrease, SREBPs are cleaved and released to act as transcription factors, binding to the promoters of genes such as the LDL receptor and HMG CoA Synthase. Binding of SREBPs to the LDL receptor promoter increases the expression of LDL receptor on the cell surface and increases the internalization of LDL from plasma, increasing cellular cholesterol levels and lowering LDL cholesterol in the plasma. Upregulation of genes such as HMG CoA synthase increases the biosynthesis of cholesterol. The SREBP proteins are cleaved and activated by two proteases, S1P (Site 1 protease) and S2P (Site 2 protease). S1P cleaves SREBP region in the ER lumen and S2P cleaves in the transmembrane region of SREBPs. Regulation by sterols is provided by SCAP. SCAP activates S1P when sterols are low, inducing SREBP activation, and does not activate S1P when sterol levels increase. Drugs acting at various steps in this process can alter cholesterol metabolism and plasma cholesterol levels that contribute to coronary heart disease. The statins such as lovastatin are drugs that inhibit cholesterol biosynthesis, lowering intracellular cholesterol levels and activating SREBP cleavage to increase LDLR expression on the cell surface. Inhibition of S1P may provide another mechanism to alter plasma cholesterol levels, as suggested by the low cholesterol levels in mice lacking the S1P gene. Ligands that bind to SCAP also lower cholesterol levels through induction of LDLR expression. (This definition may be outdated - see the DesignNote.)
MCID: MC00526903
PMOID: PMO:00014641
Subclass_of: Lipid Metabolism Pathway
Synonym: SREBP control of lipid synthesis
Tree Number: T4.7.9.16
database_cross_reference: NCI:C39226
database_cross_reference: NCI_BioC:C39226

Omega-Oxidation of Fatty Acids Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: While the main route of fatty acid metabolism is through beta-oxidation, some minor metabolic pathways such as omega oxidation also contribute to the metabolism of fatty acids and other molecules. Omega oxidation occurs in the endoplasmic reticulum rather than the mitochondria, the site of beta-oxidation. The omega carbon in a fatty acid is the carbon furthest in the alkyl chain from the carboxylic acid. In the omega oxidation pathway, this carbon is progressively oxidized first to an alcohol and then to a carboxylic acid, creating a molecule with a carboxylic acid on both ends. The first step in the pathway is catalyzed by a cytochrome P450 mixed function oxidase and requires both oxygen and NADPH. Oxidation of the alcohol is catalyzed by an alcohol dehydrogenase and aldehyde dehydrogenase catalyzes the formation of the dicarboxylic acid. If the initial substrate was a long chain fatty acid, then the resulting dicarboxylic acid can enter the beta-oxidation pathway to be shortened at both ends of the molecule at the same time. When beta-oxidation is complete, the product is short chain dicarboxylic acids like succinate or adipate. Succinate enters the Kreb's cycle, and adipate's presence in blood or urine can be monitored to determine the degree of omega oxidation in an individual. Other molecules in addition to fatty acids can also enter the omega oxidation pathway. Other molecules with long alkyl chains also enter omega oxidation, becoming more water-soluble as a result and more easily excreted from the body. Although omega oxidation is normally a minor pathway of fatty acid metabolism, failure of beta-oxidation to proceed normally can result in increased omega oxidation activity. A lack of carnitine or carnitine palmitoyltransferase activity (see Mitochondrial Carnitine Palmitoyltransferase pathway) prevents fatty acids from entering mitochondria can lead to an accumulation of fatty acids in the cell and increased omega oxidation activity. (This definition may be…
MCID: MC01394299
PMOID: PMO:00014642
Subclass_of: Lipid Metabolism Pathway
Synonym: Omega Oxidation
Synonym: Omega Oxidation Pathway
Tree Number: T4.7.9.17
database_cross_reference: NCI:C91313
database_cross_reference: NCI_BioC:C91313

Oxidation of Odd-Numbered Chain Fatty Acid Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: The beta-oxidation of fatty acids in mitochondria progressively shortens fatty acids two-carbons at a time as acetyl-CoA units are removed with each round of the cycle. Fatty acids that enter beta-oxidation with an even number of carbons are converted entirely to acetyl-CoA, with the last round producing two acetyl-CoA molecules from one four carbon fatty acid. A fatty acid that enters beta-oxidation with 18 carbons, for example, will produce 9 acetyl-CoA units. Fatty acids that have an odd number of carbons present a special challenge. The last round of beta-oxidation with a five-carbon chain releases acetyl-CoA and the 3-carbon chain propionyl-CoA. Propionyl-CoA is not a common metabolic intermediate in other pathways, so it must be converted into something else to be effectively metabolized. In addition to production from fatty acids, propionyl-CoA is derived from the metabolism of several fatty acids, including isoleucine, valine and methionine. Propionyl-CoA is converted to succinyl-CoA, an intermediate in the Kreb's cycle. Propionyl-CoA has three carbons and succinyl-CoA has four carbons, so one of the first steps in this pathway is the carboxylation of propionyl-CoA with an input of energy from ATP. Mutation of propionyl-CoA carboxylase has been observed to cause a genetic condition called propionic acidemia. The rearrangement of this molecule, first between two stereoisomers, and then two structural isomers, results in succinyl-CoA. (This definition may be outdated - see the DesignNote.)
MCID: MC01394302
PMOID: PMO:00014643
Subclass_of: Lipid Metabolism Pathway
Synonym: Conversion of Propionyl-CoA to Succinyl-CoA
Synonym: Oxidation of Odd-Numbered Chain Fatty Acid, from Propionyl-CoA to Succinyl-CoA
Tree Number: T4.7.9.18
database_cross_reference: NCI:C91314
database_cross_reference: NCI_BioC:C91314

Oxidation of Polyunsaturated Fatty Acid Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: Unsaturated fatty acids are those that contain one or more double bonds in their alkyl-chain. Polyunsaturated fats with two double bonds usually have one between carbons 9 and 10 in the alkyl chain and another three carbons away (carbons 12-13). The presence of a double bond in the fatty acid chain changes the shape of the side group, and alters membrane fluidity when present in phospholipids. Polyunsaturated fatty acids in the diet such as omega-3 fatty acids from fish oil may have a positive influence on health, reducing cardiovascular disease and cancer. The double bonds in polyunsaturated fats cannot proceed directly through beta-oxidation to generate energy. Beta-oxidation will proceed normally through the first few rounds with a polyunsaturated fat, up until the point where the beta-oxidation enzymes encounter the first double bond. The enzymes of beta-oxidation are unable to act on substrates containing a double bond between the beta and gamma carbons. To solve this problem, the enzyme enoyl-CoA isomerase moves the first double bond to a position that the beta oxidation enzymes can act on, one carbon closer to the end of the alkyl chain. Beta-oxidation can then proceed for one cycle and part of the next, until it encounters the next double bond, which usually starts at an even-numbered carbon. A reductase then reduces the fatty acid, leaving a trans-3 double bond in mammals. The enzyme 3,2 enoyl-CoA isomerase moves this double bond closer to the end of the fatty acid chain, where the fatty acid can serve as a substrate for the normal beta-oxidation enzymes to continue beta-oxidation to completion. (This definition may be outdated - see the DesignNote.)
MCID: MC01394307
PMOID: PMO:00014644
Subclass_of: Lipid Metabolism Pathway
Synonym: Oxidation of Polyunsaturated Fatty Acid
Tree Number: T4.7.9.19
database_cross_reference: NCI:C91315
database_cross_reference: NCI_BioC:C91315

Phosphatidylcholine Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: The main components of biological membranes are phosphoglyceride lipids composed of a glycerol unit esterified to two fatty acids and a polar alcohol group. The properties of phospholipids give lipid bilayer membranes their self-organizing structure. The polar alcohol group is hydrophilic and organizes itself in the membrane facing outward toward water, while the hydrophobic fatty acid alkyl chains face inward toward other fatty acid chains. One of the primary membrane phospholipids is phosphatidylcholine, in which the polar head group is composed of phosphocholine. The biosynthesis of phosphatidylcholine and phosphatidylethanolamine follow similar routes. The first step in phosphatidylcholine is the phosphorylation of choline to make phosphocholine, which is then activated by CTP. CDP-choline reacts with diacylglycerol to produce phosphatidylcholine (This definition may be outdated - see the DesignNote.)
MCID: MC01394310
PMOID: PMO:00014645
Subclass_of: Lipid Metabolism Pathway
Tree Number: T4.7.9.20
database_cross_reference: NCI:C91316
database_cross_reference: NCI_BioC:C91316

Phospholipid Degradation Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00391238
PMOID: PMO:00014646
Subclass_of: Lipid Metabolism Pathway
Synonym: phospholipid breakdown
Synonym: phospholipid catabolic process
Synonym: phospholipid catabolism
Synonym: phospholipid degradation
Tree Number: T4.7.9.21
database_cross_reference: GO:GO:0009395
database_cross_reference: MTH:NOCODE

Plasmalogen Synthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: Plasmalogens are a class of glycerophospholipids that contain one vinyl-ester linked long chain alcohol group in place of one ester-linked fatty acid chain found in other glycerophospholipids. As with the common glycerophospholipids, the polar head group of the plasmalogens is composed of ethanolamine, serine, or choline. Plasmalogens are relatively rare in some tissues but form a significant fraction of the membranes in nervous tissue. Some of the steps in plasmalogen biosynthesis are localized in peroxisomes, and some peroxisomal disorders impair plasmalogen biosynthesis. One of the starting materials for plasmalogen biosynthesis is dihydroxyacetone phosphate from glycolysis, which is used to form the glycerol backbone of the plasmalogen. In the first step, the three-carbon backbone is esterified with a fatty acid. This fatty acid ester is then exchanged leaving an ether-linked long-chain alcohol bound. Reduction of the carbonyl on the dihydroxyacetone backbone leaves a hydroxy group to be esterified with another fatty acid side chain. The polar head group such as ethanolamine is then added, and the alcohol chain modified in the last step to form the vinyl-alcohol side chain that characterizes plasmalogens. Plasmalogens serve as a starting point for the release of arachidonic acid by phospholipase A2 and the synthesis of signaling molecules derived from arachidonic acid such as prostaglandins. One plasmalogen called PAF acts through a G-protein coupled receptor as a potent platelet activator and clotting agent. The double bond of plasmalogens makes them more sensitive to oxidation than other membrane lipids, and may help to protect cells from oxidative damage. A decrease in the abundance of plasmalogens has been observed in some neurological disorders such as Alzheimer's disease. (This definition may be outdated - see the DesignNote.)
MCID: MC01394317
PMOID: PMO:00014647
Subclass_of: Lipid Metabolism Pathway
Synonym: Synthesis of Plasmalogens
Tree Number: T4.7.9.22
database_cross_reference: NCI:C91318
database_cross_reference: NCI_BioC:C91318

Prostaglandin and Leukotriene Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00524997
PMOID: PMO:00014648
Subclass_of: Lipid Metabolism Pathway
Synonym: Prostaglandin and Leukotriene Metabolism
Tree Number: T4.7.9.23
database_cross_reference: NCI:C38855
database_cross_reference: NCI_KEGG:C38855

Sphingolipid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00527645
PMOID: PMO:00014649
Subclass_of: Lipid Metabolism Pathway
Synonym: Sphingoglycolipid Metabolism
Synonym: Sphingoglycolipid Metabolism Pathway
Tree Number: T4.7.9.24
database_cross_reference: NCI:C38865
database_cross_reference: NCI_KEGG:C38865

Sphingophospholipid Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00527646
PMOID: PMO:00014650
Subclass_of: Lipid Metabolism Pathway
Synonym: Sphingophospholipid Biosynthesis
Tree Number: T4.7.9.25
database_cross_reference: NCI:C38866
database_cross_reference: NCI_KEGG:C38866

Steroid Hormone Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via dehydroepiandrosterone and delta4 pathway via androstenedione. The enzyme CYP17A1 is responsible for the 17,20 lyase and 17alpha-hydroxylase activities in respective pathways. (iii) Female hormones estrone and estradiol are formed from testosterone and 4-androstene-3,17-dione by oxidative removal of the C19 methyl group and subsequent aromatization of ring A. In addition to these three groups, recent studies show that there is another group, termed neurosteroids, synthesized in the brain rather than the peripheral endocrine gland.
MCID: MC00183127
PMOID: PMO:00014651
Subclass_of: Lipid Metabolism Pathway
Synonym: steroid hormone biosynthesis
Tree Number: T4.7.9.26
database_cross_reference: CSP:1025-7964
database_cross_reference: MTH:NOCODE

Sterol Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00389924
PMOID: PMO:00014652
Subclass_of: Lipid Metabolism Pathway
Synonym: Steroid biosynthesis
Synonym: Sterol Biosynthesis
Synonym: sterol anabolism
Synonym: sterol biosynthesis
Synonym: sterol biosynthetic process
Synonym: sterol formation
Synonym: sterol synthesis
Tree Number: T4.7.9.27
database_cross_reference: GO:GO:0016126
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38868
database_cross_reference: NCI_KEGG:C38868

Synthesis and Degradation of Ketone Bodies Pathway
type: Class
subclass of: Lipid Metabolism Pathway
MCID: MC00525301
PMOID: PMO:00014653
Subclass_of: Lipid Metabolism Pathway
Synonym: Synthesis and Degradation of Ketone Bodies
Tree Number: T4.7.9.28
database_cross_reference: NCI:C38870
database_cross_reference: NCI_KEGG:C38870

Synthesis of Cardiolipin and Phosphatidylinositol Pathway
type: Class
subclass of: Lipid Metabolism Pathway
Definition: Phosphoglycerides are lipids that contain glycerol with a phosphate ester on one end and two fatty acid ester side chains. Phosphoglycerides such as phosphatidylethanolamine and phosphatidylserine are the major component of lipid bilayer membranes in which their detergent-like properties help to provide membranes the quality of self-assembly. Phosphatidylglycerol is a phospholipid in which the phosphate ester on glycerol is joined to another glycerol. Phosphatidylglycerol is a precursor in the synthesis of both cardiolipin and phosphatidylinositol. In cardiolipin, two phosphatidylglycerol units are joined together. Cardiolipin was first identified in the heart, thus its name, and is abundant in the heart. Antibodies against cardiolipin have been observed in the blood of individuals with autoimmune disorders such as lupus. In mammals, cardiolipin is localized in mitochondria and may play a role in oxidative phosphorylation. Changes in cardiolipin levels with age might alter mitochondrial function and contribute to the aging process. Another derivative of phosphatidylglycerol is phosphatidylinositol in which the sugar inositol forms the phosphate ester. Inositol is an important intermediary in intracellular signaling pathways. Esterification of inositol with phosphates at various positions alters its interaction with different signaling proteins. Phosphatidylinositol can be phosphorylated at two positions to create PIP2. Hydrolysis of PIP2 by phospholipase C in response to GPCR activation releases IP3, which acts as a cytoplasmic second messenger to stimulate calcium release. (This definition may be outdated - see the DesignNote.)
MCID: MC01394315
PMOID: PMO:00014654
Subclass_of: Lipid Metabolism Pathway
Synonym: Synthesis of Cardiolipin & Phosphatidylinositol
Tree Number: T4.7.9.29
database_cross_reference: NCI:C91317
database_cross_reference: NCI_BioC:C91317

Melanogenesis Pathway
type: Class
subclass of: Metabolic Pathway
Definition: Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism.
MCID: MC00815367
PMOID: PMO:00014655
Subclass_of: Metabolic Pathway
Synonym: Melanogenesis
Tree Number: T4.7.10
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91468
database_cross_reference: NCI_KEGG:C91468

Metabolic Pathways of Other Amino Acids
type: Class
subclass of: Metabolic Pathway
MCID: MC00524294
PMOID: PMO:00014656
Subclass_of: Metabolic Pathway
Synonym: Metabolism of Other Amino Acids - Reference Pathway
Tree Number: T4.7.11
database_cross_reference: NCI:C39731
database_cross_reference: NCI_KEGG:C39731

Aminophosphonate Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
Definition: Natural products containing carbon-phosphorous bonds, so-called C-P compounds, are derivatives of phosphonate and phosphinate with substitution of alkyl group for hydrogen of phosphorus-hydrogen bonds. C-P compounds have been found in many organisms, but only protists and bacteria, mostly Actinobacteria, have biosynthetic capacity. A common reaction in the biosynthetic pathway is C-P bond forming reaction from phosphoenolpyruvate (PEP) to phosphonopyruvate (PnPy) catalyzed by PEP phosphomutase. 2-Aminoethylphosphonate (AEP) is the most abundant C-P compound in the natural world. AEP derivatives include phosphonoprotein, phosphonoglycan, and phosphonolipid. Other known C-P compounds are bioactive substances used in medicine (antibiotics) and agriculture (herbicide) such as fosfomycin, FR-33289, rhizocticin, and bialaphos.
MCID: MC00523059
PMOID: PMO:00014657
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Aminophosphonate Metabolism
Synonym: Phosphonate and phosphinate metabolism
Synonym: aminophosphonate metabolic process
Synonym: aminophosphonate metabolism
Tree Number: T4.7.11.1
database_cross_reference: GO:GO:0033051
database_cross_reference: NCI:C38780
database_cross_reference: NCI_KEGG:C38780

Beta-Alanine Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
MCID: MC00390195
PMOID: PMO:00014658
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Beta-Alanine Metabolism
Synonym: beta-alanine metabolic process
Synonym: beta-alanine metabolism
Tree Number: T4.7.11.2
database_cross_reference: GO:GO:0019482
database_cross_reference: NCI:C38788
database_cross_reference: NCI_KEGG:C38788

Cyanoamino Acid Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
MCID: MC00523436
PMOID: PMO:00014659
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Cyanoamino Acid Metabolism
Synonym: cyanoamino acid metabolic process
Synonym: cyanoamino acid metabolism
Tree Number: T4.7.11.3
database_cross_reference: GO:GO:0033052
database_cross_reference: NCI:C38798
database_cross_reference: NCI_KEGG:C38798

D-Alanine Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
MCID: MC00390167
PMOID: PMO:00014660
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: D-Alanine Metabolism
Synonym: D-alanine metabolic process
Synonym: D-alanine metabolism
Tree Number: T4.7.11.4
database_cross_reference: GO:GO:0046436
database_cross_reference: NCI:C38801
database_cross_reference: NCI_KEGG:C38801

D-Arginine and D-Ornithine Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
MCID: MC00523484
PMOID: PMO:00014661
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: D-Arginine and D-Ornithine Metabolism
Tree Number: T4.7.11.5
database_cross_reference: NCI:C38802
database_cross_reference: NCI_KEGG:C38802

D-Glutamine and D-Glutamate Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
MCID: MC00523485
PMOID: PMO:00014662
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: D-Glutamine and D-Glutamate Metabolism
Tree Number: T4.7.11.6
database_cross_reference: NCI:C38803
database_cross_reference: NCI_KEGG:C38803

Glutathione Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
MCID: MC00391454
PMOID: PMO:00014663
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Glutathione Metabolism
Synonym: glutathione metabolic process
Synonym: glutathione metabolism
Tree Number: T4.7.11.7
database_cross_reference: CHV:0000055346
database_cross_reference: GO:GO:0006749
database_cross_reference: NCI:C38815
database_cross_reference: NCI_KEGG:C38815

Selenoamino Acid Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
MCID: MC00527552
PMOID: PMO:00014664
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Selenoamino Acid Metabolism
Tree Number: T4.7.11.8
database_cross_reference: NCI:C38864
database_cross_reference: NCI_KEGG:C38864

Taurine and Hypotaurine Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
MCID: MC00525387
PMOID: PMO:00014665
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Taurine and Hypotaurine Metabolism
Tree Number: T4.7.11.9
database_cross_reference: NCI:C38871
database_cross_reference: NCI_KEGG:C38871

Mitochondrial Carnitine Palmitoyltransferase Pathway
type: Class
subclass of: Metabolic Pathway
Definition: The oxidation of fatty acids is an important source of energy for ATP production in mitochondria through the entry of acetyl-CoA into the Krebs cycle. Fatty acids are oxidized inside the mitochondrial matrix but the fatty acids to be oxidized come from the cytosol. Fatty acids are activated in the cytosol by esterification with Coenzyme A (CoA) to form acyl-CoA (RCO-CoA, where R is the fatty acid acyl group). Activated medium-chain fatty acids (C8 and C10) freely diffuse into mitochondria to be oxidized but long chain fatty acids must be transported in. The transport of long chain fatty acids into mitochondria for oxidation is accomplished by the carnitine palmitoyltransferase system (CPTI and CPTII). CPTI exchanges carnitine for the CoA attached to long chain fatty acids to form a fatty acid-carnitine conjugate (RCO-carnitine). The fatty acid-carnitine is transported into the matrix by a transporter protein in the inner mitochondrial membrane. Once the fatty acid-carnitine is inside the matrix, CPTII exchanges CoA for carnitine to produce fatty acid-CoA once again, ready to enter fatty acid oxidation in the matrix to produce energy. The free carnitine is transported back out to renew the cytoplasmic pool of carnitine and allow the transfer process to continue. (This definition may be outdated - see the DesignNote.)
MCID: MC00524414
PMOID: PMO:00014666
Subclass_of: Metabolic Pathway
Synonym: Mitochondrial Carnitine Palmitoyltransferase (CPT) System
Tree Number: T4.7.12
database_cross_reference: NCI:C39035
database_cross_reference: NCI_BioC:C39035

Neurotransmitter Biosynthesis Pathway
type: Class
subclass of: Metabolic Pathway
Definition: Neurotransmitters are signaling molecules used by neurons to communicate across chemical synapses. The receptors for neurotransmitters include G-protein coupled receptors (GPCRs) and ligand-gated ion channels. The biogenic amines are neurotransmitters derived from amino acids, and include dopamine, epinephrine, GABA, histamine and serotonin. For each of these, decarboxylation of an amino acid is a key step. GABA, gamma-aminobutyric acid, is a key inhibitory neurotransmitter and is synthesized through the decarboxylation of glutamate in a single step. Glutamate is itself an abundant excitatory neurotransmitter. Histamine signals are involved in inflammation and acid secretion in the stomach, acting through GPCRs. Histamine is synthesized in a single step from the amino acid histidine through decarboxylation. Serotonin is a neurotransmitter with a large range of effects, including roles in mood and depression, and is synthesized by first adding a hydroxyl group to tryptophan, followed by decarboxylation. A common mechanism of antidepressant action is to block the reuptake of serotonin at synapses. Dopamine is involved in movement and mood and is derived from tyrosine through addition of a hydroxyl group and decarboxylation. Additional reactions create norepinephrine and epinephrine from dopamine. These molecules, also called adrenalin and noradrenalin, act on the adrenergic receptors to exert responses including alteration of blood pressure, heart rate, metabolic activity, and bronchodilation. Many common drugs such as asthma and heart pressure medications act on adrenergic receptors. Alterations in these biosynthetic pathways can lead to significant clinical consequences. For example, deficiency in tyrosine hydroxylase activity leads to a movement disorder similar to Parkinson's disease and may play a role in Parkinson's disease and the development of an autoimmune response against glutamate decarboxylase (GAD) may trigger the destruction of insulin-secreting cells a…
MCID: MC01394338
PMOID: PMO:00014667
Subclass_of: Metabolic Pathway
Synonym: Biosynthesis of Neurotransmitters
Tree Number: T4.7.13
database_cross_reference: NCI:C91323
database_cross_reference: NCI_BioC:C91323

Nucleotide Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
MCID: MC01393667
PMOID: PMO:00014668
Subclass_of: Metabolic Pathway
Synonym: Nucleotide Metabolism - Reference Pathway
Tree Number: T4.7.14
database_cross_reference: NCI:C39729
database_cross_reference: NCI_KEGG:C39729

Purine Metabolism Pathway
type: Class
subclass of: Nucleotide Metabolism Pathway
MCID: MC01394120
PMOID: PMO:00014669
Subclass_of: Nucleotide Metabolism Pathway
Synonym: Purine Metabolism
Tree Number: T4.7.14.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38858
database_cross_reference: NCI_KEGG:C38858

Pyrimidine Metabolism Pathway
type: Class
subclass of: Nucleotide Metabolism Pathway
MCID: MC00323290
PMOID: PMO:00014670
Subclass_of: Nucleotide Metabolism Pathway
Synonym: Pyrimidine Metabolism
Synonym: metabolism pyrimidines
Synonym: pyrimidine metabolism
Tree Number: T4.7.14.2
database_cross_reference: CHV:0000052624
database_cross_reference: CSP:2503-4410
database_cross_reference: GO:GO:0006206
database_cross_reference: GO:GO:0006213
database_cross_reference: GO:GO:0006220
database_cross_reference: NCI:C38859
database_cross_reference: NCI_KEGG:C38859

Peroxisome Biogenesis Pathway
type: Class
subclass of: Metabolic Pathway
Definition: Peroxisomes are essential organelles that play a key role in redox signaling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
MCID: MC01393683
PMOID: PMO:00014671
Subclass_of: Metabolic Pathway
Synonym: Peroxisome
Tree Number: T4.7.15
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91498
database_cross_reference: NCI_KEGG:C91498

Regulation of Cholesterol Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
Definition: Cholesterol is essential for life but a key in the development of heart disease. Cholesterol homeostasis is achieved through regulation of cholesterol uptake, cholesterol biosynthesis, cholesterol conversion to bile acids and excretion of bile acids. Inhibition of cholesterol biosynthesis up regulates LDLR expression and is the mechanism of action of many drugs used to lower plasma LDL to reduce coronary heart disease. Many aspects of cholesterol homeostasis are regulated by the nuclear receptors FXR and LXR, both nuclear receptor transcription factors that form heterodimers with the retinoic acid RXR receptors and that are activated by cholesterol metabolites. One of the primary tissues in cholesterol metabolism is the liver, a key site of cholesterol biosynthesis and where cholesterol low-density lipoprotein (LDL) is taken up from the plasma by the LDL-receptor. When cholesterol accumulates in liver cells, some of the cholesterol is oxidized to create oxysterols. Oxysterols activate LXR through LXR/RXR heterodimers to activate genes such as the CYP7A1 enzyme that catalyzes the rate-limiting step in bile acid biosynthesis and a major route for the elimination of cholesterol. Animals lacking the CYP7A1 enzyme accumulate cholesterol in the liver. In the intestine LXR activates the ABC-1 gene, a transporter that actively transports cholesterol out of cells to clear it from the body. Activation of ABC-1 expression by LXR in macrophages in atherosclerotic plaques appears to be another mechanism by which LXR plays a role in heart disease. The FXR receptor is activated by bile acids. In the liver, activation of FXR-RXR heterodimers by bile acids results in the feedback inhibition of CYP7A expression and reduced biosynthesis of bile acids. In the intestine, FXR activates expression of I-BABP, a protein that increases the transport of bile acids back to the liver from the intestine, reducing their excretion. Drugs targeting the FXR and LXR receptors could play an important …
MCID: MC00525166
PMOID: PMO:00014672
Subclass_of: Metabolic Pathway
Synonym: FXR and LXR Regulation of Cholesterol Metabolism
Tree Number: T4.7.16
database_cross_reference: NCI:C39085
database_cross_reference: NCI_BioC:C39085

Ribosomal Biogenesis Pathway
type: Class
subclass of: Metabolic Pathway
Definition: Cyclin-dependent kinase inhibitor-2A (CDKN2A) goes by the colloquial designation p16, which is sometimes referred to as p16(INK4). The alpha transcript of CDKN2A has been shown to encode p16(INK4a), a recognized tumor suppressor that induces a G1 cell cycle arrest by inhibiting the phosphorylation of the RB protein by the cyclin-dependent kinases CDK4 and CDK6. The beta transcript of CDKN2A encodes p14(ARF). The predicted 132-amino acid p14(ARF) is shorter than the corresponding mouse protein, p19(ARF), and the 2 proteins share only 50% identity. However, both proteins have the ability to elicit a p53 response, manifest in the increased expression of both CDKN1A and MDM2, and resulting in a distinctive cell cycle arrest in both the G1 and G2/M phases. Two unrelated proteins encoded by the INK4A-ARF locus function in tumor suppression. ARF binds to MDM2 and promotes the rapid degradation of MDM2. This interaction is mediated by the E1-beta-encoded N-terminal domain of ARF and a C-terminal region of MDM2. ARF-promoted MDM2 degradation is associated with MDM2 modification and concurrent p53 stabilization and accumulation. The p19(Arf) tumor suppressor inhibits production of ribosomal RNA, retarding processing of 47/45S and 32S precursors. These effects correlate with but do not strictly depend upon inhibition of rRNA biosynthesis or cell cycle arrest, are not mimicked by p53, and require neither p53 nor Mdm2. Arf mutants lacking conserved amino acid residues 2-14 do not block rRNA synthesis and processing or inhibit cell proliferation. Evolution may have linked a primordial nucleolar Arf function to Mdm2 and p53, creating a more efficient checkpoint-signaling pathway for coordinating ribosomal biogenesis and cell cycle progression. (This definition may be outdated - see the DesignNote.)
MCID: MC00525219
PMOID: PMO:00014673
Subclass_of: Metabolic Pathway
Synonym: Tumor Suppressor Arf Inhibits Ribosomal Biogenesis
Tree Number: T4.7.17
database_cross_reference: NCI:C38992
database_cross_reference: NCI_BioC:C38992

Regulatory Pathway
type: Class
subclass of: Biochemical Pathway
Definition: An elaboration of the known or inferred interactions controlling the expression of a product.
MCID: MC01394088
PMOID: PMO:00014674
Subclass_of: Biochemical Pathway
Tree Number: T4.8
database_cross_reference: NCI:C19779

Angiogenesis Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Vascular endothelial growth factor (VEGF) plays a key role in physiological blood vessel formation and pathological angiogenesis such as tumor growth and ischemic diseases. Hypoxia is a potent inducer of VEGF in vitro. The increase in secreted biologically active VEGF protein from cells exposed to hypoxia is partly because of an increased transcription rate, mediated by binding of hypoxia-inducible factor-1 (HIF1) to a hypoxia responsive element in the 5'-flanking region of the VEGF gene. bHLH-PAS transcription factor that interacts with the Ah receptor nuclear translocator (Arnt), and its predicted amino acid sequence, exhibits significant similarity to the hypoxia-inducible factor 1alpha (HIF1a) product. HLF mRNA expression is closely correlated with that of VEGF mRNA. The high expression level of HLF mRNA in the O2 delivery system of developing embryos and adult organs suggests that in a normoxic state, HLF regulates gene expression of VEGF, various glycolytic enzymes, and others driven by the HRE sequence, and may be involved in development of blood vessels and the tubular system of lung. VEGF expression is dramatically induced by hypoxia due in large part to an increase in the stability of its mRNA. HuR binds with high affinity and specificity to the VRS element that regulates VEGF mRNA stability by hypoxia. In addition, an internal ribosome entry site (IRES) ensures efficient translation of VEGF mRNA even under hypoxia. The VHL tumor suppressor (von Hippel-Lindau) regulates also VEGF expression at a post-transcriptional level. The secreted VEGF is a major angiogenic factor that regulates multiple endothelial cell functions, including mitogenesis. Cellular and circulating levels of VEGF are elevated in hematologic malignancies and are adversely associated with prognosis. Angiogenesis is a very complex, tightly regulated, multistep process, the targeting of which may well prove useful in the creation of novel therapeutic agents. Current approaches being investig…
MCID: MC00523069
PMOID: PMO:00014675
Subclass_of: Regulatory Pathway
Synonym: VEGF, Hypoxia, and Angiogenesis
Tree Number: T4.8.1
database_cross_reference: NCI:C39264
database_cross_reference: NCI_BioC:C39264

Apoptosis Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: A representation of the sequence of biological or biochemical events that are involved in the regulation of or result in apoptosis.
MCID: MC01393665
PMOID: PMO:00014676
Subclass_of: Regulatory Pathway
Tree Number: T4.8.2
database_cross_reference: NCI:C39699

AIF Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others that are caspase independent. Like cytochrome C, AIF (apoptosis-inducing factor) is a protein found in mitochondria that is released from mitochondria by apoptotic stimuli. While cytochrome C is linked to caspase-dependent apoptotic signaling, AIF release stimulates caspase-independent apoptosis, moving into the nucleus where it binds DNA. DNA binding by AIF stimulates chromatin condensation, and DNA fragmentation, perhaps through recruitment of nucleases. DNA-binding by AIF occurs through a distinct domain of the protein in a manner that does not rely on specific DNA sequences. AIF also has another domain that acts as an NADH oxidase, a redox enzyme. The NADH oxidase activity of AIF is separable from its DNA-binding activity and is not required for AIF to induce apoptosis. In this role, AIF protects against apoptosis rather than inducing apoptosis. In mice down regulation of the AIF gene created harlequin mice with oxidative damage to neurons and increased neuronal cell death. Loss of AIF also increased sensitivity to peroxides, suggesting that AIF may act as a peroxide scavenger. The mechanism by which AIF protects against peroxide damage is not clear, but may involve a more indirect mechanism than direct peroxide scavenging since the enzyme does not appear to have this activity in vitro. Elucidating further the role of AIF as a redox enzyme will shed further light on its normal function in mitochondria as well as its role in apoptosis and disease. (This definition may be outdated - see the DesignNote.)
MCID: MC00525858
PMOID: PMO:00014677
Subclass_of: Apoptosis Regulation Pathway
Synonym: Opposing roles of AIF in Apoptosis and Cell Survival
Tree Number: T4.8.2.1
database_cross_reference: NCI:C38977
database_cross_reference: NCI_BioC:C38977

Apoptosis DNA Damage Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: The cellular activation of the caspase cascade resulting in cell death is triggered by chemical damage to DNA which stimulates a sequence resulting in the cleavage of BID or directly initiates the permeability transition of the mitochondrial membrane. The permeability transition releases several factors including cytochrome c, AIF and other factors in to the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase cascade. The caspases are a class of cysteine proteases that includes several representatives involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death. (This definition may be outdated - see the DesignNote.)
MCID: MC00525985
PMOID: PMO:00014678
Subclass_of: Apoptosis Regulation Pathway
Synonym: Apoptotic Signaling in Response to DNA Damage
Tree Number: T4.8.2.2
database_cross_reference: NCI:C39028
database_cross_reference: NCI_BioC:C39028

Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis.
MCID: MC00063348
PMOID: PMO:00014679
Subclass_of: Apoptosis Regulation Pathway
Synonym: Apoptosis
Synonym: Apoptosis (morphologic abnormality)
Synonym: Apoptotic Process
Synonym: Gene-directed cell death
Synonym: Mechanism that allows cells to self-destruct when it is necessary
Synonym: PCD
Synonym: Programmed Cell Death
Synonym: Programmed Cell Death, Type I
Synonym: RCD
Synonym: apoptose
Tree Number: T4.8.2.3
database_cross_reference: AOD:0000002370
database_cross_reference: CHV:0000017920
database_cross_reference: CSP:4001-0010
database_cross_reference: GO:GO:0006915
database_cross_reference: GO:GO:0012501
database_cross_reference: GO:GO:0097194
database_cross_reference: LCH_NW:sh91000743
database_cross_reference: MDR:10059512
database_cross_reference: MSH:D017209
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17557
database_cross_reference: NCI:C38784
database_cross_reference: NCI_KEGG:C38784
database_cross_reference: NCI_NCI-GLOSS:CDR0000046524
database_cross_reference: NCI_NCI-GLOSS:CDR0000407582
database_cross_reference: SNMI:M-54250
database_cross_reference: SNOMEDCT_US:20663007

Apoptotic DNA Fragmentation Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: Apoptotic cell death can be triggered by many different cellular stimuli, resulting in activation of apoptotic signaling pathways including caspases and mitochondria. A cellular response that is characteristic of apoptosis is fragmentation of the nuclear genome to create a nucleosomal ladder. This activity is conducted by multiple nucleases activated by apoptotic signaling pathways. One nuclease involved in apoptosis is DNA fragmentation factor (DFF), a caspase-activated DNAse (CAD). DFF/CAD is activated through cleavage of its associated inhibitor ICAD by caspases proteases during apoptosis. DFF/CAD interacts with chromatin components such as topo II and histone H1 to condense chromatin structure and perhaps recruit CAD to chromatin. Another apoptosis activated protease is endonuclease G, EndoG. EndoG is encoded in the nuclear genome but is localized to mitochondria in normal cells. EndoG may play a role in the replication of the mitochondrial genome, as well as in apoptosis. Apoptotic signaling causes the release of EndoG from mitochondria. Mitochondria are involved in apoptotic signaling in other ways as well, through the release of cytochrome c induced by Bid to activate the caspase protease cascade. These pathways are independent since the EndoG pathway still occurs in cells lacking DFF. (This definition may be outdated - see the DesignNote.)
MCID: MC00525986
PMOID: PMO:00014680
Subclass_of: Apoptosis Regulation Pathway
Synonym: Apoptotic DNA fragmentation and tissue homeostasis
Tree Number: T4.8.2.4
database_cross_reference: NCI:C39051
database_cross_reference: NCI_BioC:C39051

Caspase Cascade in Apoptosis
type: Class
subclass of: Apoptosis Regulation Pathway
PMOID: PMO:00014681
Subclass_of: Apoptosis Regulation Pathway
Tree Number: T4.8.2.5

Caspase Cascade Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: Apoptosis, programmed cell death, is triggered by a variety of stimuli, including cell surface receptors like FAS, mitochondrial response to stress, and cytotoxic T cells. Caspases are a class of cysteine proteases that includes several representatives involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death. The caspases at the upper end of the cascade include caspase-8 and caspase-9. Caspase-8 is the initial caspase involved in response to receptors with a death domain like FAS. The mitochondrial stress pathway begins with the release of cytochrome c from mitochondria, which then interacts with Apaf-1, causing self-cleavage and activation of caspase-9. Caspase-3, -6, and -7 are downstream caspases that are activated by the upstream proteases and act themselves to cleave cellular targets. Granzyme B and perforin proteins released by cytotoxic T cells induce apoptosis in target cells, forming transmembrane pores, and triggering apoptosis, perhaps through cleavage of caspases, although caspase-independent mechanisms of Granzyme B mediated apoptosis have been suggested. (This definition may be outdated - see the DesignNote.)
MCID: MC00526093
PMOID: PMO:00014682
Subclass_of: Apoptosis Regulation Pathway
Synonym: Caspase Activation Cascade in Apoptosis
Synonym: Caspase Cascade in Apoptosis
Synonym: Caspase cascade in apoptosis
Tree Number: T4.8.2.6
database_cross_reference: NCI:C39014
database_cross_reference: NCI:C91560
database_cross_reference: NCI_BioC:C39014
database_cross_reference: NCI_PID:C91560

Dentatorubropallidoluysian Atrophy (DRPLA) Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
MCID: MC01394256
PMOID: PMO:00014683
Subclass_of: Apoptosis Regulation Pathway
Synonym: Dentatorubropallidoluysian Atrophy (DRPLA)
Tree Number: T4.8.2.7
database_cross_reference: NCI:C38804
database_cross_reference: NCI_KEGG:C38804

DR3 and DR4/5 Mediated Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: Apoptosis is specifically induced via signaling through a family of receptors known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. Apo3L recruits initiator caspase 8 via the adapter protein FADD. Caspase 8 then oligomerizes and is activated via autocatalysis. Activated caspase 8 stimulates apoptosis via two parallel cascades: it directly cleaves and activates caspase-3, and it cleaves Bid (a Bcl-2 family protein). Truncated Bid (tBid) translocates to mitochondria, inducing cytochrome C release, which sequentially activates caspases 9 and 3. DR-3L can deliver pro- or anti-apoptotic signals. DR-3 promotes apoptosis via the adaptor proteins TRADD/FADD and the activation of caspase 8. Alternatively, apoptosis is inhibited via an adaptor protein complex including RIP which activates NF-kB and induces survival genes including IAP. Induction of apoptosis via Apo2L requires caspase activity, but the adaptor requirement is unclear. (This definition may be outdated - see the DesignNote.)
MCID: MC00523531
PMOID: PMO:00014684
Subclass_of: Apoptosis Regulation Pathway
Synonym: Induction of apoptosis through DR3 and DR4/5 Death Receptors
Tree Number: T4.8.2.8
database_cross_reference: NCI:C39049
database_cross_reference: NCI_BioC:C39049

Erythropoietin Neuroprotection Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: Erythropoietin (Epo) is most commonly known as the cytokine secreted by the kidneys that stimulates red blood cell production and is used as a drug for the treatment of anemias. Epo is also secreted in the brain in response to hypoxia, such as ischemic stroke. Epo production in the brain is stimulated by the hypoxia-inducible transcription factor HIF-1 (see HIF pathway). Administration of Epo to the brain in rodents before hypoxic stress or other neuronal stresses is neuroprotective, preventing neuronal apoptosis. The erythropoietin receptor (EpoR) is known to associate with JAK kinases that phosphorylate and activate the STAT family of transcription factors. The neuroprotection by Epo involves cross-talk between Epo receptor and anti-apoptotic pathways through activation of NF-kB by the JAK2 kinase. Epo stimulates JAK2 phosphorylation of I-kB, releasing NF-kB to translocate into the nucleus and activate transcription of neuroprotective genes. Neuroprotective genes activated by NF-kB include the anti-oxidant enzyme manganese superoxide dismutase and calbindin-D28k. The erythropoietin receptor is also essential for proper brain development in mice. The absence of EpoR causes high levels of neuronal apoptosis in the developing mouse brain, further confirming the important role of Epo as a neuroprotective agent. (This definition may be outdated - see the DesignNote.)
MCID: MC00526387
PMOID: PMO:00014685
Subclass_of: Apoptosis Regulation Pathway
Synonym: Erythropoietin mediated neuroprotection through NF-kB
Tree Number: T4.8.2.9
database_cross_reference: NCI:C39066
database_cross_reference: NCI_BioC:C39066

Free Radical Induced Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: Oxidative stress is one factor that can trigger programmed cell death. Activated neutrophils responding to inflammatory stimulation produce reactive oxygen species like superoxide free radicals to kill invading bacteria, but these reactive oxygen species can also attack endothelial cells lining the vascular wall and trigger apoptosis. Endothelial cells also produce reactive oxygen species inside the cell that can contribute to oxidative stress and apoptosis, such as during reperfusion injury following ischemia. Superoxide dismutase (SOD) converts highly reactive and damaging superoxide free radicals to peroxides that are less reactive than superoxide but stimulate apoptosis. The glutathione (GSH) peptide reducing agent removes toxic metabolites and repairs damage created by reactive oxygen species. Glutathione peroxidase (GPx), for example, removes peroxides using glutathione as a reducing agent, and glutathione reductase (GSR) regenerates reduced glutathione. Inside the endothelial cell peroxide can be converted to hydroxyl ions in the presence of iron. Peroxides and hydroxyl radicals activate NF-kB and activate expression of inflammatory genes including adhesion molecules, TNF and IL-8. The apoptotic response of endothelial cells to oxidative stress may be involved in the development and progression of atherosclerosis. (This definition may be outdated - see the DesignNote.)
MCID: MC00526552
PMOID: PMO:00014686
Subclass_of: Apoptosis Regulation Pathway
Synonym: Free Radical Induced Apoptosis
Tree Number: T4.8.2.10
database_cross_reference: NCI:C39084
database_cross_reference: NCI_BioC:C39084

Granzyme A Mediated Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: One mechanism used by cytotoxic T cells to kill tumor cells and virus-infected cells is the release of perforin and granzyme proteins. Perforin proteins form pores in the membranes of the attacked cell, allowing the entry of Granzyme A and Granzyme B. Granzyme B induces caspase activation and cleavage of factors like ICAD, releasing DFF40 to fragment DNA, one of the hallmarks of apoptotic cell death. Granzyme A is also an abundant granzyme released by cytotoxic T cells and is important in cytotoxic T cell induced apoptosis, activating caspase independent pathways. Once in a cell, Granzyme A activates DNA nicking by the recently identified DNAse NM23-H1, a tumor suppressor gene product whose expression is reduced in transformed, metastatic cells. The previous identification of NM23-H1 as a tumor suppressor indicates that its DNAse activity plays an important role in immune surveillance to prevent cancer through the induction of tumor cell apoptosis. The activation of NM23-H1 occurs indirectly, through the cleavage of proteins that inhibit NM23-H1 in the SET complex, which includes SET, Ape1, pp32 and HMG2. SET is a substrate for the Granzyme A protease, and SET cleavage relieves NM23-H1 inhibition to cause apoptotic DNA degradation. In addition to inhibiting NM23-H1, SET has nucleosome assembly activity and also may help the interaction of transcriptional regulation with chromatin structure by interacting with the transcriptional coactivator CBP. The targets of Granzyme A found in the SET complex also have other important functions. Ape1 repairs oxidative DNA damage, reduces transcription factors involved in immediate early responses, and its cleavage by Granzyme A may contribute to DNA degradation and apoptosis. HMG2 is an acidic chromatin-associated protein that bends DNA, alters chromatin structure and alters the accessibility of genes for transcription. In addition to acting as a nucleosome assembly factor and an inhibitor of NM23-H1, SET inhibits DNA and histone…
MCID: MC01394066
PMOID: PMO:00014687
Subclass_of: Apoptosis Regulation Pathway
Synonym: Granzyme A mediated Apoptosis Pathway
Tree Number: T4.8.2.11
database_cross_reference: NCI:C39230
database_cross_reference: NCI_BioC:C39230

HIV Induced T Cell Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be caused by HIV-induced apoptosis of both infected and uninfected helper T cells. HIV uses the CCR5 chemokine receptor as a coreceptor for macrophage cell entry and upregulates fas-ligand on these cells. CD4 on helper T cells is essential for viral cell entry and infection. Cross-linking of CD4 on the T cell surface may be involved in upregulation of Fas and sensitization of T cells to apoptosis induced by the Fas/Fas-ligand interaction. (This definition may be outdated - see the DesignNote.)
MCID: MC00523860
PMOID: PMO:00014688
Subclass_of: Apoptosis Regulation Pathway
Synonym: HIV Induced T Cell Apoptosis
Tree Number: T4.8.2.12
database_cross_reference: NCI:C39244
database_cross_reference: NCI_BioC:C39244

HIV-I Nef in Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: HIV infection leads to drastic declines in CD4 T helper cells, in part through apoptosis of uninfected cells. Apoptosis of uninfected cells may be induced through the expression of Fas ligand on the surface of HIV-infected cells, stimulating the Fas-dependent apoptotic pathway in cells that come in contact with infected cells. The NEF protein expressed by HIV may play a role in the inducing the expression of Fas-ligand by infected cells. If this is the case, then a question that arises is how infected cells themselves escape Fas-mediated apoptosis. The NEF protein appears to play a role in this process as well. NEF interacts with the ASK1 kinase (apoptosis signal-regulating kinase) involved in apoptotic signaling by TNF and Fas-ligand. Interaction of NEF with ASK1 prevents phosphorylation of downstream MAP kinases and JNK kinases involved in apoptotic signaling. (This definition may be outdated - see the DesignNote.)
MCID: MC00523858
PMOID: PMO:00014689
Subclass_of: Apoptosis Regulation Pathway
Synonym: HIV-I Nef: negative effector of Fas and TNF
Tree Number: T4.8.2.13
database_cross_reference: NCI:C39106
database_cross_reference: NCI_BioC:C39106

IGF1R Antiapoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: IGF-1R, the type 1 receptor for insulin-like growth factor, mediates cell survival and growth in response to its ligands IGF-1 and IGF-2. This tyrosine kinase receptor is widely expressed in many cell types and is a key mediator of growth. Overexpression or activation of IGF-1R may be involved in the proliferation of transformed cells, making inhibition of IGF-1R signaling a strategy for the development of cancer drugs. IGF-1R activates three signaling pathways that converge to phosphorylate BAD protein and block apoptosis. The first pathway activated by IGF-1R stimulates PI3-kinase and the AKT pathway to phosphorylate BAD and block apoptosis. A second pathway activated by IGF-1R involves ras mediated activation of the map kinase pathway to block apoptosis. A third pathway involves interaction of raf with mitochondria in response to IGF-1R activation. The convergence of these pathways to block apoptosis may enhance the IGF-1R response. (This definition may be outdated - see the DesignNote.)
MCID: MC00523997
PMOID: PMO:00014690
Subclass_of: Apoptosis Regulation Pathway
Synonym: Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
Tree Number: T4.8.2.14
database_cross_reference: NCI:C39115
database_cross_reference: NCI_BioC:C39115

Nerve Growth Factor Receptor Signaling Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
MCID: MC00388944
PMOID: PMO:00014691
Subclass_of: Apoptosis Regulation Pathway
Synonym: p75(NTR) Signaling Pathway
Synonym: p75(NTR)-mediated signaling
Tree Number: T4.8.2.15
database_cross_reference: NCI:C91644
database_cross_reference: NCI_PID:C91644

Regulation of Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is less clear. Although nicotinic acetylcholine receptors are primarily known for their action as ligand-gated ion channels transducing action potentials across synapses, they may have other actions. Nicotinic acetylcholine receptors in neurons alter apoptotic signaling, protecting against cell death in some settings, and this action may in some cases be directed through alternative signaling pathways. In neurons the alpha-7 nicotinic receptor activates PI3 kinase through a src-family kinase, activating the anti-apoptotic kinase AKT (See AKT signaling pathway). One pathway involved in AKT signaling involves phosphorylation of the forkhead transcription factor FKHRL1, causing its retention in the cytoplasm associated with 14-3-3, and blocking expression of the apoptotic fas protein. The PI3 kinase/AKT pathway protects a broad range of neurons against apoptotic cell death and may block apoptosis triggered by beta-amyloid fragments that contributes to the progression of Alzheimer's disease. If so, nicotinic agents may prove useful in the treatment of this and other neurodegenerative conditions. There are several proteins that modulate the response of nicotinic acetylcholine receptors, include synapse formation. Prior to synapse formation, nicotinic receptors are randomly dispersed in the post-synaptic membrane. A neuronal protein, agrin, binds to the Musk receptor in the muscle membrane, stimulating clustering of nicotinic receptors and synapse formation. Rapsyn is present at high levels at synapses with nicotinic receptors, bringing them together at high densities and anchoring clustered receptors to the cytoskeleton. Members of the Src family of tyrosine kinases also play a role in clustering caused by Rapsyn, phosphorylating the nicotinic receptors, rapsyn, and other targets. Nicotinic receptors expressed in non-neuronal ti…
MCID: MC00525165
PMOID: PMO:00014692
Subclass_of: Apoptosis Regulation Pathway
Synonym: Role of nicotinic acetylcholine receptors in the regulation of apoptosis
Tree Number: T4.8.2.16
database_cross_reference: NCI:C38971
database_cross_reference: NCI_BioC:C38971

T-Cell Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: Mef2 (Myocyte enhancer factor 2) transcription factors play a role in T-Cell calcium induced apoptosis. Several factors regulate Mef2 transcription factors, including Map kinases and histone deacetylase (HDAC) enzymes. (This definition may be outdated - see the DesignNote.)
MCID: MC00525306
PMOID: PMO:00014693
Subclass_of: Apoptosis Regulation Pathway
Synonym: Role of MEF2D in T-cell Apoptosis
Tree Number: T4.8.2.17
database_cross_reference: NCI:C39149
database_cross_reference: NCI_BioC:C39149

TSP-1 Induced Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
Definition: As tissues grow they require angiogenesis to occur if they are to be supplied with blood vessels and survive. Factors that inhibit angiogenesis might act as cancer therapeutics by blocking vessel formation in tumors and starving cancer cells. Thrombospondin-1 (TSP-1) is a protein that inhibits angiogenesis and slows tumor growth, apparently by inducing apoptosis of microvascular endothelial cells that line blood vessels. TSP-1 appears to produce this response by activating a signaling pathway that begins with its receptor, CD36, at the cell surface of the microvascular endothelial cell. The non-receptor tyrosine kinase fyn is activated by TSP-1 through CD36, activating the apoptosis inducing proteases such as caspase-3 and p38 protein kinases. p38 is a mitogen-activated kinase that also induces apoptosis in some conditions, perhaps through AP-1 activation and the activation of genes that lead to apoptosis. (This definition may be outdated - see the DesignNote.)
MCID: MC00525356
PMOID: PMO:00014694
Subclass_of: Apoptosis Regulation Pathway
Synonym: TSP-1 Induced Apoptosis in Microvascular Endothelial Cell
Tree Number: T4.8.2.18
database_cross_reference: NCI:C39260
database_cross_reference: NCI_BioC:C39260

ATF-2 Transcription Factor Signaling Pathway
type: Class
subclass of: Regulatory Pathway
MCID: MC01393786
PMOID: PMO:00014695
Subclass_of: Regulatory Pathway
Synonym: ATF-2 transcription factor network
Tree Number: T4.8.3
database_cross_reference: NCI:C91544
database_cross_reference: NCI_PID:C91544

BAD Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112, 136, and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway. BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kinase A inhibitors. (This definition may be outdated - see the DesignNote.)
MCID: MC00526026
PMOID: PMO:00014696
Subclass_of: Regulatory Pathway
Synonym: Regulation of BAD phosphorylation
Tree Number: T4.8.4
database_cross_reference: NCI:C38998
database_cross_reference: NCI_BioC:C38998

Cadmium Induction Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Exposure to divalent cadmium ions (Cd2+) is a known cancer risk factor, but the molecular mechanisms responsible for the inappropriate induction of cellular proliferation by cadmium are still being figured out. One cellular model used to study this process is macrophages grown in culture. In cultured macrophages, cadmium acts both at the cell surface and in the cytoplasm to induce proliferation. At the cell surface, cadmium interacts with a pertussis-sensitive cell surface receptor, probably a Gi-coupled GPCR, to stimulate proliferation. Cadmium can enter cells through calcium ion channels and once in cells affects calcium release by the ER. In addition to changes in intracellular calcium, the proliferative effects of cadmium are mediated by the Ras/Map kinase pathway, and also NF-kB. Inhibition of phospholipase C, map kinases, or NF-kB with a variety of pharmacological inhibitors all blocked the activation of cellular proliferation by cadmium. Protein kinase C is also activated by cadmium, upstream of the Map kinase pathway. Changes in transcription induced by cadmium include induction of immediate early genes like fos, jun, and myc. In addition to inducing cellular proliferation, cadmium also is slightly genotoxic due to inhibition of DNA repair, activates stress genes, and inhibits the immune system. The immunomodulatory effects observed with cadmium treatment may also involvement transcriptional disregulation, including the expression of cytokines such as IL-4, IL-10, and TNF-alpha. Although macrophages have been used for many studies, other cell types are also the target of cadmium's toxicity. (This definition may be outdated - see the DesignNote.)
MCID: MC00523398
PMOID: PMO:00014697
Subclass_of: Regulatory Pathway
Synonym: Cadmium induces DNA synthesis and proliferation in macrophages
Tree Number: T4.8.5
database_cross_reference: NCI:C39023
database_cross_reference: NCI_BioC:C39023

Calmodulin Pathway
type: Class
subclass of: Regulatory Pathway
Definition: The calcium/calmodulin-dependent kinases (CaMKs) are involved in a large number of cellular responses induced by hormones, neurotransmitters and other signaling. Elevation of calcium functions as a major second messenger, where the intracellular concentration of calcium can be maintained at extremely low levels and subsequently increased following specific calcium-mobilizing stimuli. There are many buffers to the calcium fluctuations including membrane pumps and calcium-binding proteins that create discrete spatial control of its effectors and their targets. The current family of multifunctional calcium/calmodulin (CaM)-dependent protein kinases (CaMKs) consists of CaMKI, CaMKII and CaMKIV. These kinases translate and co-ordinate the calcium fluctuations into the appropriate cellular responses via phosphorylation. These kinases are partially regulated by the intracellular calcium receptor calmodulin (CaM), and have common as well as unique features in their structure, regulation and activation. CaMKII, CaMKI and CaMKIV, have an autoregulatory domain that restricts or inhibits enzymatic activity in the absence of calcium/CaM. Calcium/CaM binding alone produces maximal activity of CaMKII, whereas CaMKI and CaMKIV have an activation loop that requires phosphorylation of a threonine residue by CaMK kinase (CaMKK) for maximal activity. Two genes (alpha and beta) for CaMKK, which is also regulated by CaM, have been identified. The highest expression of these isoforms occurs in the brain but the activity of the CaMKs has been identified in most cell types. CaMKIV has a post-calmodulin autophosphorylation step that is not observed in CaMKI. The CaMKII multimer can autophosphorylate either the autoregulatory domain or the CaM-binding domain, producing diverse effects in its regulation and sensitivity to Calcium/CaM. Autophosphorylation of CaMKII can produce Calcium/CaM- independent activity (autonomous activity), without affecting its maximal Calcium/CaM-stimulated activity.…
MCID: MC00526049
PMOID: PMO:00014698
Subclass_of: Regulatory Pathway
Synonym: Ca++/ Calmodulin-dependent Protein Kinase Activation
Tree Number: T4.8.6
database_cross_reference: NCI:C39009
database_cross_reference: NCI_BioC:C39009

CARM1 Transcription Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. (This definition may be outdated - see the DesignNote.)
MCID: MC00523351
PMOID: PMO:00014699
Subclass_of: Regulatory Pathway
Synonym: Transcription Regulation by Methyltransferase of CARM1
Tree Number: T4.8.7
database_cross_reference: NCI:C39012
database_cross_reference: NCI_BioC:C39012

CDK Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Initiation of DNA replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to restrict initiation events to once per replication origin per S phase. Its control has been uncovered by the discovery of the cyclin dependent kinases (CDKs) as master regulators of the cell cycle and the initiator proteins of DNA replication, such as the Origin Recognition Complex (ORC), Cdc6/18, Cdt1 and the mini-chromosome maintenance complex (Mcm). The proteins and the sequence of events involved in this process are conserved throughout the eukaryotic kingdom. First, the ORC comprised of six proteins binds to replication origins in the chromosomal DNA. At the end of mitosis, ORC, Cdc6/18 and Cdt1 assist the binding of Mcm proteins 2-7 to chromatin, and chromatin becomes licensed for replication. The activated Mcm complex functions as a replicating helicase and moves along with the replication fork to bring the origins to the unlicensed state. The cycling of CDK activity in the cell cycle regulates the two states of replication origins, the licensed state in G1-phase and the unlicensed state for the rest of the cell cycle. The restriction on licensing is relieved when CDK falls off at the completion of mitosis to allow a new round of replication. (This definition may be outdated - see the DesignNote.)
MCID: MC00523369
PMOID: PMO:00014700
Subclass_of: Regulatory Pathway
Synonym: CDK Regulation of DNA Replication
Tree Number: T4.8.8
database_cross_reference: NCI:C39148
database_cross_reference: NCI_BioC:C39148

Cell Cycle Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: A representation of the sequence of biological or biochemical events that are involved in the regulation of the cell cycle.
MCID: MC01393931
PMOID: PMO:00014701
Subclass_of: Regulatory Pathway
Tree Number: T4.8.9
database_cross_reference: NCI:C39700

AKAP8 in Mitosis Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: Chromatin packaging of the genome is dynamic, changing with the cell cycle and with transcriptional regulation. During mitosis, chromatin is condensed for segregation of chromosomes, while for transcription chromatin is more open. The nuclear matrix, or scaffold, is a protein network in the nucleus providing structure and regulating chromatin condensation. Regulated interactions of matrix proteins with each other, DNA and other factors in different phases of the cell cycle alter the structure and function of chromatin. AKAP95 (A-kinase anchoring protein) is a nuclear matrix associated protein that also binds DNA and different proteins during different phases of the cell cycle. The interaction of AKAP95 with DNA and proteins alters the condensation and transcription of chromatin. A specific domain of AKAP95 regulates its interaction with the nuclear matrix and another regulates its association with DNA. One key protein that AKAP95 interacts with is the cAMP-dependent protein kinase, PKA. AKAP95 binds to PKA through a PKA RII regulatory subunit, an interaction that requires PKA phosphorylation by Cdk1. PKA activity and cAMP are reduced during entry into mitosis, but PKA recruited by AKAP95 to condensed chromosomes is essential to maintain the condensed state. Another protein recruited by AKAP95 is Eg7, a 150 kD protein recruited during mitotic chromatin condensation. Eg7 is a part of a multiprotein condensin complex, recruiting another key component of mitotic chromatin condensation. Modification of the core histones through phosphorylation regulates chromatin condensation. Histone H3 interacts with the condensin complex, and is phosphorylated during mitosis. Histone H3 phosphorylation by Aurora-2 induces chromatin condensation, and dephosphorylation by PP1 promotes chromatin decondensation for reentry into interphase. AKAP95 may play a role during the regulation of chromatin structure for transcription during interphase as well. The interaction of AKAP95 with the p68…
MCID: MC00525859
PMOID: PMO:00014702
Subclass_of: Cell Cycle Regulation Pathway
Synonym: AKAP95 role in mitosis and chromosome dynamics
Tree Number: T4.8.9.1
database_cross_reference: NCI:C38979
database_cross_reference: NCI_BioC:C38979

Aurora Kinase Signaling Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
MCID: MC01394181
PMOID: PMO:00014703
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Signaling by Aurora kinases
Tree Number: T4.8.9.2
database_cross_reference: NCI:C91546
database_cross_reference: NCI_PID:C91546

Aurora A Signaling Pathway
type: Class
subclass of: Aurora Kinase Signaling Pathway
MCID: MC01394185
PMOID: PMO:00014704
Subclass_of: Aurora Kinase Signaling Pathway
Synonym: Aurora A signaling
Tree Number: T4.8.9.2.1
database_cross_reference: NCI:C91547
database_cross_reference: NCI_PID:C91547

Aurora B Signaling Pathway
type: Class
subclass of: Aurora Kinase Signaling Pathway
MCID: MC01394188
PMOID: PMO:00014705
Subclass_of: Aurora Kinase Signaling Pathway
Synonym: Aurora B signaling
Tree Number: T4.8.9.2.2
database_cross_reference: NCI:C91548
database_cross_reference: NCI_PID:C91548

Aurora C Signaling Pathway
type: Class
subclass of: Aurora Kinase Signaling Pathway
MCID: MC01394191
PMOID: PMO:00014706
Subclass_of: Aurora Kinase Signaling Pathway
Synonym: Aurora C signaling
Tree Number: T4.8.9.2.3
database_cross_reference: NCI:C91549
database_cross_reference: NCI_PID:C91549

BTG Cell Cycle Regulation Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: BTG2 is found to be one of the immediate early genes up-regulated by neural growth factor (NGF) and epidermal growth factor (EGF). Its transcriptional level is also up-regulated by p53, gamma radiation, adriamycin, and UV treatment of cells. BTG seems to be important for the cell cycle progression as BTG2 is preferentially expressed in quiescent cells. Over-expression of BTG2 decreases the growth of NIH3T3 cells and induces neuronal differentiation and prevention apoptosis of PC12 cells. Molecularly, BTG2 expression induces hypophosphorylation of RB and G1 arrest which could be rescued by overexpression of cyclin D1. BTG1 and BTG2 interact with PRMT1 (predominant cellular arginine N-methyltransferase) and increase PRMT1 methyltransferase activity. Box C domain in BTG1 and 2 are responsible for the interaction. Box C domain alone acts as a dominant negative which blocks PRMT1 activity. PRMT1 activity is essential for NGF induced PC12 differentiation, and blocking PRMT1 by Box C domain of BTG1 or 2 induces apoptosis. In addition, BTG2 and HoxB9 interaction enhances the transcription of Hoxb9. Lastly, association of BTG2 and BTG1 with Caf1 is also reported to modulate transcriptional activity of CAF1. (This definition may be outdated - see the DesignNote.)
MCID: MC00523165
PMOID: PMO:00014707
Subclass_of: Cell Cycle Regulation Pathway
Synonym: BTG family proteins and cell cycle regulation
Tree Number: T4.8.9.3
database_cross_reference: NCI:C39008
database_cross_reference: NCI_BioC:C39008

CDC25 and CHK1 Regulatory Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into the M-phase of the cell cycle. Cdc25 is phosphorylated throughout interphase but not in mitosis. The primary site for phosphorylation of cdc25 is Ser216. Phosphorylated cdc25 binds to members of the 14-3-3 family of proteins which prevents its activation of cdc2. Chk1, a protein kinase involved in the DNA damage checkpoint response in fission yeast, has been shown to phosphorylate cdc25 at Ser216 in vitro. (This definition may be outdated - see the DesignNote.)
MCID: MC00523363
PMOID: PMO:00014708
Subclass_of: Cell Cycle Regulation Pathway
Synonym: cdc25 and chk1 Regulatory Pathway in response to DNA damage
Tree Number: T4.8.9.4
database_cross_reference: NCI:C39020
database_cross_reference: NCI_BioC:C39020

Cell Cycle Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
MCID: MC00002434
PMOID: PMO:00014709
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Cell Cycle
Synonym: Cell Cycles
Synonym: Cell Division Cycle
Synonym: Cell Division Cycles
Synonym: Cell cycle
Synonym: Cycle, Cell
Synonym: Cycle, Cell Division
Synonym: Cycles, Cell
Synonym: Cycles, Cell Division
Synonym: Division Cycle, Cell
Tree Number: T4.8.9.5
database_cross_reference: AOD:0000002348
database_cross_reference: CHV:0000002583
database_cross_reference: CSP:0600-2965
database_cross_reference: GO:GO:0007049
database_cross_reference: LCH:U000866
database_cross_reference: LCH_NW:sh85021643
database_cross_reference: MSH:D002453
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38794
database_cross_reference: NCI_KEGG:C38794

Cell Cycle Progression Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: The focus of this pathway is to illustrate the role of Polo-like Kinase 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading to apoptosis and the arrest cell cycle progression prior to M phase. Phosphorylation of Cdc25C on serine-216 causes the arrest of the cell cycle at the G2/M phase border by preventing Cdc25C from activating cyclinB1/Cdk1. Xie et al. demonstrated that Plk3, like Chk1 and Chk2, also phosphorylates Cdc25C on serine-216 contributing to cell cycle arrest. Additionally they found that Plk3 also phosphorylates p53 on serine 20, a step that is stimulatory in the process leading up to p53-mediated apoptosis. Wang Q et al. found that Plk3 is closely associated with the centrosome and that this is dependent on the integrity of the microtubules. Expression of constitutively active or defective Plk3 kinase had significant defects on the shape and nature of the microtubule apparatus of the cell. In either case cell cycle progression was halted and apoptosis occurred. (This definition may be outdated - see the DesignNote.)
MCID: MC00526106
PMOID: PMO:00014710
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Regulation of cell cycle progression by Plk3
Tree Number: T4.8.9.6
database_cross_reference: NCI:C39195
database_cross_reference: NCI_BioC:C39195

Cyclin Regulation of Cell Cycle Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Key among these are p53, the cdk inhibitors (p15, p16, p18, p19, p21, p27), and Rb, all of which act to keep the cell cycle from progressing until all repairs to damaged DNA have been completed. (This definition may be outdated - see the DesignNote.)
MCID: MC00523445
PMOID: PMO:00014711
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Cyclins and Cell Cycle Regulation
Tree Number: T4.8.9.7
database_cross_reference: NCI:C39025
database_cross_reference: NCI_BioC:C39025

E2F Transcription Factor Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
MCID: MC01394106
PMOID: PMO:00014712
Subclass_of: Cell Cycle Regulation Pathway
Synonym: E2F transcription factor network
Tree Number: T4.8.9.8
database_cross_reference: NCI:C91574
database_cross_reference: NCI_PID:C91574

EFP Cell Cycle Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: The estrogen-inducible RING finger protein Efp stimulates proliferation of breast cancer cells. 14-3-3 is p53-inducible protein that sequesters mitotic Cdks in the cytoplasm to inhibit entry into mitosis. To allow cell-cycle progression, estrogens stimulate production of Efp, which binds and ubiquinates 14-3-3s sigma. 14-3-3s marked with ubiquitin chains is recognized and destroyed by the proteasome. Released Cdks are now free to escape into the nucleus and promote mitotic entry. (This definition may be outdated - see the DesignNote.)
MCID: MC00523735
PMOID: PMO:00014713
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
Tree Number: T4.8.9.9
database_cross_reference: NCI:C39057
database_cross_reference: NCI_BioC:C39057

G1 to S Transition Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: The cell cycle transition from G1 to S phase is a key regulatory point in the cell cycle. This transition is regulated by the checkpoint kinase cdk2 that activates the G1 to S transition when it is associated with cyclin E. Cdk2/Cyclin E causes the G1 to S transition through phosphorylation of the tumor suppressor Rb, releasing the transcription factor E2F-1. Other pathways acting through Rac, Ras, and Rho also regulate the G1 to S transition. Ras regulates cyclin D1 expression to affect the G1 to S transition. Transforming forms of Ras or Raf induce cyclin D1 expression and cause early entry into S phase. Signaling from Ras to Raf to MEK to ERKs induces Cyclin D1 expression, allowing Cyclin D1 to complex with Cdk4 and Cdk6 and phosphorylate Rb. Rac-1 and PAK appear to induce Cyclin D1 expression and induce the G1 to S transition primarily through activation of NF-kB to activate the Cyclin D1 promoter. Rho activates cdk2 and also inhibits p21 and p27 to induce cyclin D1 and stimulate the G1 to S transition. Rho represses p21 expression to block p21 induction by Ras and to allow Ras induced progression from G1 to S. Cells that lack p21 do not require Rho for Ras to induce cell cycle progression from G1 to S phase. The cooperative action of Ras, Rac and Rho to induce Cyclin D1 expression is a key component of oncogenic transformation. (This definition may be outdated - see the DesignNote.)
MCID: MC00526570
PMOID: PMO:00014714
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Influence of Ras and Rho proteins on G1 to S Transition
Tree Number: T4.8.9.10
database_cross_reference: NCI:C39210
database_cross_reference: NCI_BioC:C39210

G1/S Checkpoint Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: The G1/S cell cycle checkpoint controls the passage of eukaryotic cells from the first 'gap' phase (G1) into the DNA synthesis phase (S). Two cell cycle kinases, CDK4/6-cyclin D and CDK2-cyclin E, and the transcription complex that includes Rb and E2F are pivotal in controlling this checkpoint. During G1 phase, the Rb-HDAC repressor complex binds to the E2F-DP1 transcription factors, inhibiting downstream transcription. Phosphorylation of Rb by CDK4/6 and CDK2 dissociates the Rb-repressor complex, permitting transcription of S-phase genes encoding for proteins that amplify the G1 to S phase switch and that are required for DNA replication. Many different stimuli exert checkpoint control including TGFb, DNA damage, contact inhibition, replicative senescence, and growth factor withdrawal. The first four act by inducing members of the INK4 or Kip/Cip families of cell cycle kinase inhibitors. TGFb additionally inhibits the transcription of Cdc25A, a phosphatase that activates the cell cycle kinases. Growth factor withdrawal activates GSK3b, which phosphorylates cyclin D, leading to its rapid ubiquitination and proteasomal degradation. Ubiquitination, nuclear export, and degradation are mechanisms commonly used to rapidly reduce the concentration of cell-cycle control proteins. (This definition may be outdated - see the DesignNote.)
MCID: MC00526569
PMOID: PMO:00014715
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Cell Cycle: G1/S Check Point
Tree Number: T4.8.9.11
database_cross_reference: NCI:C39086
database_cross_reference: NCI_BioC:C39086

G2/M Checkpoint Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: The G2/M DNA damage checkpoint prevents the cell from entering mitosis (M phase) if the genome is damaged. The Cdc2-cyclin B kinase is pivotal in regulating this transition. During G2 phase, Cdc2 is maintained in an inactive state by the kinases Wee1 and Mt1. As cells approach M phase, the phosphatase Cdc25 is activated, perhaps by the polo-kinase Pik1. Cdc25 then activates Cdc2, establishing a feedback amplification loop that efficiently drives the cell into mitosis. DNA damage activates the DNA-PK/ATM/ATR kinases, initiating two parallel cascades that inactivate Cdc2-cyclin B. The first cascade rapidly inhibits progression into mitosis: the CHK kinases phosphorylate and inactivate Cdc25, which can no longer activate Cdc2. The second cascade is slower. Phosphorylation of p53 dissociates it from MDM2, activating its DNA binding activity. Acetylation by p300/PCAF further activates its transcriptional activity. The genes that are turned on by p53 constitute effectors of this second cascade. They include 14-3-3s, which binds to the phosphorylated Cdc2-cyclin B kinase and exports it from the nucleus; GADD45, which apparently binds to and dissociates the Cdc2-cyclin B kinase; and p21Cip1, an inhibitor of a subset of the cyclin-dependent kinases including Cdc2 (CDK1). (This definition may be outdated - see the DesignNote.)
MCID: MC00526573
PMOID: PMO:00014716
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Cell Cycle: G2/M Checkpoint
Synonym: G2 M Cell Cycle Checkpoint
Synonym: G2-M Cell Cycle Checkpoint
Tree Number: T4.8.9.12
database_cross_reference: MSH:D059565
database_cross_reference: NCI:C39088
database_cross_reference: NCI_BioC:C39088

p27 Regulation Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: p27/Kip1 regulates the cell cycle by inhibiting the checkpoint kinase cdk2/cyclin E and blocking cell cycle progression through the G1-S transition. Cancer cells in some cases have reduced levels of p27, supporting the importance of p27 in cell cycle regulation. The activity of p27 is regulated by phosphorylation, synthesis and degradation. Phosphorylation of p27 at threonine-187 by cdk2 causes p27 to associate with an SCF complex that targets p27 for proteolytic degradation. The F box protein Skp2 binds specifically to threonine-187 phosphorylated p27, recruiting it to the SCF complex for degradation. Other components of the p27 ubiquitin ligase complex include Skp1, Cul1, and Roc1/Rbx-1. Cks-1 has also been identified in a reconstituted system as an essential component for recruitment of p27 for degradation by the SCF complex. Signaling by cytokines may modulate cell survival, proliferation, or apoptosis through modulation of p27 expression. Cytokine and AKT signaling pathways activate forkhead transcription factors that induce p27 expression at the transcriptional level. (This definition may be outdated - see the DesignNote.)
MCID: MC00525733
PMOID: PMO:00014717
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Regulation of p27 Phosphorylation during Cell Cycle Progression
Tree Number: T4.8.9.13
database_cross_reference: NCI:C39176
database_cross_reference: NCI_BioC:C39176

p53 Signaling Pathway BioCarta
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: p53 is a transcription factor who's activity is regulated by phosphorylation. The function is p53 is to keep the cell from progressing through the cell cycle if there is damage to DNA present. It may do this in multiple ways from holding the cell at a checkpoint until repairs can be made to causing the cell to enter apoptosis if the damage cannot be repaired. The critical role of p53 is evidenced by the fact that it is mutated in a very large fraction of tumors from nearly all sources. (This definition may be outdated - see the DesignNote.)
MCID: MC00525735
PMOID: PMO:00014718
Subclass_of: Cell Cycle Regulation Pathway
Synonym: p53 Signaling Pathway
Tree Number: T4.8.9.14
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39180
database_cross_reference: NCI_BioC:C39180

p53 Signaling Pathway KEGG
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
MCID: MC00815369
PMOID: PMO:00014719
Subclass_of: Cell Cycle Regulation Pathway
Synonym: p53 signaling pathway
Tree Number: T4.8.9.15
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91495
database_cross_reference: NCI_KEGG:C91495

Polo-like Kinase Signaling Pathway in the Cell Cycle
type: Class
subclass of: Cell Cycle Regulation Pathway
MCID: MC01393756
PMOID: PMO:00014720
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Polo-like kinase signaling events in the cell cycle
Tree Number: T4.8.9.16
database_cross_reference: NCI:C91650
database_cross_reference: NCI_PID:C91650

PLK1 Signaling Pathway
type: Class
subclass of: Polo-like Kinase Signaling Pathway in the Cell Cycle
MCID: MC01393759
PMOID: PMO:00014721
Subclass_of: Polo-like Kinase Signaling Pathway in the Cell Cycle
Synonym: PLK1 signaling events
Tree Number: T4.8.9.16.1
database_cross_reference: NCI:C91651
database_cross_reference: NCI_PID:C91651

PLK2 and PLK4 Signaling Pathway
type: Class
subclass of: Polo-like Kinase Signaling Pathway in the Cell Cycle
MCID: MC01393762
PMOID: PMO:00014722
Subclass_of: Polo-like Kinase Signaling Pathway in the Cell Cycle
Synonym: PLK2 and PLK4 events
Tree Number: T4.8.9.16.2
database_cross_reference: NCI:C91652
database_cross_reference: NCI_PID:C91652

PLK3 Signaling Pathway
type: Class
subclass of: Polo-like Kinase Signaling Pathway in the Cell Cycle
MCID: MC01393764
PMOID: PMO:00014723
Subclass_of: Polo-like Kinase Signaling Pathway in the Cell Cycle
Synonym: PLK3 signaling events
Tree Number: T4.8.9.16.3
database_cross_reference: NCI:C91653
database_cross_reference: NCI_PID:C91653

Ptc1 Regulation of Cell Cycle Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: Sonic Hedgehog (Shh) is a secreted protein identified genetically as an important developmental factor. Shh provides a morphogenic signal in the developing CNS, organizing the spatial patterning of cells in the midbrain and inducing proliferation of neuronal precursor cells in the developing cerebellum, neural tube, and retina. Proliferative signaling by Shh is involved in the development of cancer, including specific brain and skin cancers such as basal cell carcinomas. Sonic hedgehog signaling may proceed by more than one mechanism. One signaling pathway is activated by Shh binding to Patched (Ptc-1) which releases inhibition of the GPCR Smoothened, activating the Shh signaling pathway and allowing progression through the G1 phase of the cell cycle. Shh can also affect progression through the G2/M transition. Patched binds to phosphorylated Cyclin B1, one component of the M-phase promoting factor (MPF), along with the kinase Cdc2. The interaction of Cyclin B1 with Patched blocks MPF activity, blocking progression through the G2/M transition. Shh binding leads to degradation of Ptc-1, release of Cyclin B1, and entry of the cyclin B1 into the nucleus. Patched acts as a tumor suppressor by blocking MPF activity. Blockade of the Hedgehog pathway by cyclopamine demonstrated the therapeutic potential of Hedgehog inhibition in the treatment of some cancers. (This definition may be outdated - see the DesignNote.)
MCID: MC01394078
PMOID: PMO:00014724
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle
Tree Number: T4.8.9.17
database_cross_reference: NCI:C39203
database_cross_reference: NCI_BioC:C39203

PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
Definition: PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of phosphatidylinositol 3-kinase. Many of the cancer-related mutations have been mapped to the phosphatase catalytic domain; it has been suggested that the phosphatase activity of PTEN is required for its tumor suppressor function. The activation of PKB/AKT is regulated in a complex manner via phosphorylation of AKT on Thr308 and Ser473 by PDK1 and ILK (integrin-linked kinase) respectively. Inactivation of PTEN will constitutively activate PKB/AKT pathway. In addition to its role in regulating the PI 3-K/AKT cell survival pathway, PTEN also inhibits growth factor-induced Shc phosphorylation and suppresses the mitogen-activated protein (MAP) kinase signaling pathway. PTEN also interacts with FAK, a key molecule implicated in integrin signaling pathways, and it directly dephosphorylates tyrosine-phosphorylated FAK. PTEN down-regulation of p130CAS through FAK results in inhibition of cell migration and spreading. (This definition may be outdated - see the DesignNote.)
MCID: MC00527370
PMOID: PMO:00014725
Subclass_of: Cell Cycle Regulation Pathway
Synonym: PTEN dependent cell cycle arrest and apoptosis
Tree Number: T4.8.9.18
database_cross_reference: NCI:C39205
database_cross_reference: NCI_BioC:C39205

Regulation of Retinoblastoma Protein Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
MCID: MC01393802
PMOID: PMO:00014726
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Regulation of retinoblastoma protein
Tree Number: T4.8.9.19
database_cross_reference: NCI:C91663
database_cross_reference: NCI_PID:C91663

Centrosome Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Protein kinase A regulatory subunit RII-alpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-kinase anchoring protein AKAP350 (also known as AKAP450 and CGNAP), MAP2 and Pericentrin. This diagram illustrates these three PKA-RII binding complexes. The cyclin B-p34(cdc2) kinase (CDK1) has been shown to phosphorylate PKA-RIIa on T54 and this has been proposed to alter the subcellular localization of PKA-RIIa at the onset of mitosis. It has been demonstrated that PKA-RIIa dissociates and redistributes from centrosomes at mitosis. The focal point of this illustration is the AKAP350 complex. In addition to binding PKA-RIIa, AKAP350 binds PKN (Takahashi et al 1999) and the phosphatases PP1 and PPA2 (Takahashi et al 1999). PKN is a serine/threonine protein kinase, having a catalytic domain homologous to the PKC family in the C-terminal region and a unique regulatory region in the N-terminal region. PKN is activated by a small GTPase RhoA and unsaturated fatty acids such as arachidonic acid. The binding of both kinases and phosphatases by the same scaffold protein provides a focal point where physiological events, such as cell cycle progression and intracellular membrane traffic, may be regulated by phosphorylation state of specific protein substrates. There are at least 4 isoforms of AKAP350 which lead to the possibility that they may behave differently at different subcellular locations. MAP2 is a member of a group of proteins that provide microtubule stabilization. MAP2 affinity appears to be dependent on PKA phosphorylation of MAP2. Pericentrin is also an AKAP (Diviani and Scott). Pericentrin binds Dynein which is also regulated by PKA leading to the possibility that pericentrin positions PKA to regulate dynein function (Diviani and Scott). (This definition may be outdated - see the DesignNote.)
MCID: MC00526138
PMOID: PMO:00014727
Subclass_of: Regulatory Pathway
Synonym: Protein Kinase A at the Centrosome
Tree Number: T4.8.10
database_cross_reference: NCI:C38980
database_cross_reference: NCI_BioC:C38980

CFTR Pathway
type: Class
subclass of: Regulatory Pathway
Definition: The defects in cAMP-regulated chloride channel CTFR are believed to be the major cause for cystic fibrosis. Regulation of CFTR protein by the surface receptor beta adrenergic receptor is mediated through the ezrin/radixin/moesin binding phosphoprotein 50 (EBP50), which binds both the C-termini CFTR and b2AR through their PDZ binding motifs. In the resting state, CFTR, b2AR, and EBP50 exist as a macromolecular complex on the apical surface of epithelial cells. Upon agonist activation of the b2AR, the adenylate cyclase is stimulated through the G protein pathway, leading to an increase in cAMP. The elevated concentration of cAMP activates PKA, which is anchored near CFTR via interaction with Ezrin. The phosphorylation of CFTR by PKA disrupts the complex and leads to compartmentalized and specific signaling of the channel. (This definition may be outdated - see the DesignNote.)
MCID: MC00523371
PMOID: PMO:00014728
Subclass_of: Regulatory Pathway
Synonym: Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway
Tree Number: T4.8.11
database_cross_reference: NCI:C39027
database_cross_reference: NCI_BioC:C39027

ChREBP Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through transcriptional regulation by the glucose responsive transcription factor ChREBP. ChREBP, carbohydrate responsive element binding protein, is a transcription factor that is activated by high levels of carbohydrates and repressed by cAMP. The activation of ChREBP by elevated carbohydrate levels increases the activity of genes involved in glucose metabolism such as pyruvate kinase, a rate-limiting enzyme in glycolysis, increasing the overall rate of utilization of carbohydrates. Excess carbohydrates also increase the transcription of genes that convert carbohydrates to triglycerides in the liver for storage in adipose tissue. cAMP regulates ChREBP activity by activating PKA, which phosphorylates ChREBP. Phosphorylation of ChREBP at ser(196) inactivates nuclear import and phosphorylation at Thr(666) prevents DNA binding by ChREBP. A metabolite of glucose activates protein phosphatase PP2A that then dephosphorylates both sites on ChREBP in response to increased glucose levels and increases ChREBP activity. Other pathways also regulate ChREBP activity and response to nutrients. High fat diets repress ChREBP activation by increasing AMP in liver cells, activating the AMP kinase. Phosphorylation of ChREBP by AMP kinase inactivates ChREBP and blocks glucose induction of ChREBP, linking dietary fatty acids to the regulation of carbohydrate metabolism. (This definition may be outdated - see the DesignNote.)
MCID: MC00526174
PMOID: PMO:00014729
Subclass_of: Regulatory Pathway
Synonym: ChREBP regulation by carbohydrates and cAMP
Tree Number: T4.8.12
database_cross_reference: NCI:C39029
database_cross_reference: NCI_BioC:C39029

Chromatin Remodeling Complex and Coactivator Pathway
type: Class
subclass of: Regulatory Pathway
Definition: RXR and RAR are nuclear receptors that bind either all trans retinoic (tRA) or 9cis retinoic acid (9cisRA). In the absence of ligand corepressors with histone deacetylase activity are bound to the RAR/RXR heterodimer and suppress transcription. Once they bind retinoic acid a conformational change in the receptors cause the dissociation of the corepressors and the binding of coactivators with histone acetylase activity. Following ligand binding by the heterodimer the receptors and proteins in the basal transcription machinery (like TBP and TAF135) are degraded by the proteasome. (This definition may be outdated - see the DesignNote.)
MCID: MC00526208
PMOID: PMO:00014730
Subclass_of: Regulatory Pathway
Synonym: Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
Tree Number: T4.8.13
database_cross_reference: NCI:C39216
database_cross_reference: NCI_BioC:C39216

CK1/CDK5 Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Cdk5 is a cyclin dependent protein kinase involved in dopaminergic signaling in the neostriatal region of the brain. The role of cdk5 in dopamine responses occurs through phosphorylation of DARPP-32. Casein kinase 1 (CK1) also regulates DARPP-32 phosphorylation and dopamine signaling. The phosphorylation of DARPP-32 by cdk5 reduced dopamine signaling. Depending on its phosphorylation state, DARPP-32 inhibits either protein phosphatase 1 (PP1) or PKA. The role of mGLUR1 in this process is supported by the induction of cdk5 and CK1 activity by the mGLUR1 agonist DHPG and the subsequent phosphorylation of DARPP-32 associated with DHPG treatment of nigrostriatal neurons. CK-1 and Ckd5 inhibitors block the DHPG induced DARPP-32 phosphorylation. Dopamine exerts a positive signal that increases dopamine response by reversing phosphorylation of DARPP-32 at threonine-75. Dopamine initiates this pathway through activation of the D1 dopamine receptor, a Gs coupled GPCR, elevating cAMP and activating PKA. PKA activates protein phosphatase 2A (PP2A) which dephosphorylates DARPP-32 and increases dopamine responsiveness. This also removes the inhibition of PKA by DARPP-32, forming a positive feedback loop for further DARPP-32 inactivation by PKA. Activation of the D2 dopamine receptor has the opposite effect, shifting the DARPP-32 population toward the threonine-75 phosphorylated form. (This definition may be outdated - see the DesignNote.)
MCID: MC00523376
PMOID: PMO:00014731
Subclass_of: Regulatory Pathway
Synonym: Regulation of ck1/cdk5 by type 1 glutamate receptors
Tree Number: T4.8.14
database_cross_reference: NCI:C39031
database_cross_reference: NCI_BioC:C39031

CTCF Pathway
type: Class
subclass of: Regulatory Pathway
Definition: CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF. Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic inactivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptional activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is a multivalent DNA-sequence binder whose specificity is mediated by different sets of zinc finger (ZF) proteins. (This definition may be outdated - see the DesignNote.)
MCID: MC00523383
PMOID: PMO:00014732
Subclass_of: Regulatory Pathway
Synonym: CTCF: First Multivalent Nuclear Factor
Tree Number: T4.8.15
database_cross_reference: NCI:C39040
database_cross_reference: NCI_BioC:C39040

DBPB Transcriptional Activation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Endothelial cells respond to treatment with the protease thrombin with increased secretion of the PDGF B-chain. This activation occurs at the transcriptional level and a thrombin response element was identified in the promoter of the PDGF B-chain gene. A transcription factor called the DNA-binding protein B (dbpB) mediates the activation of PDGF B-chain transcription in response to thrombin treatment. DbpB is a member of the Y box family of transcription factors and binds to both RNA and DNA. In the absence of thrombin, endothelial cells contain a 50 kD form of dbpB that binds RNA in the cytoplasm and may play a role as a chaperone for mRNA. The 50 kD version of dbpB also binds DNA to regulate genes containing Y box elements in their promoters. Thrombin activation results in the cleavage of dbpB to a 30 kD form. The proteolytic cleavage releases dbpB from RNA in the nucleus, allowing it to enter the nucleus and binds to a regulatory element distinct from the site recognized by the full length 50 kD dbpB. The genes activated by cleaved dbpB include the PDGF B chain. Dephosphorylation of dbpB also regulates nuclear entry and transcriptional activation. RNA digestion in vitro can release dbpB in its active form, suggesting that the protease responsible for dbpB may be closely associated in a complex. Identification of the protease that cleaves dbpB, the mechanisms of phosphorylation and dephosphorylation, and elucidation of the signaling path by which thrombin induces dbpB will provide greater understanding of this novel signaling pathway. (This definition may be outdated - see the DesignNote.)
MCID: MC00523488
PMOID: PMO:00014733
Subclass_of: Regulatory Pathway
Synonym: Transcriptional activation of dbpb from mRNA
Tree Number: T4.8.16
database_cross_reference: NCI:C39046
database_cross_reference: NCI_BioC:C39046

EGF Receptor Downregulation by CBL Pathway
type: Class
subclass of: Regulatory Pathway
Definition: As with many cell-surface receptors, activation of the EGF receptor can result in receptor internalization through receptor-mediated endocytosis, desensitizing further receptor signaling. This process requires clathrin and occurs in clathrin-coated pits, which pinch off from the plasma membrane to form vesicles that move to the early endosome. From the early endosome, receptors can either be recycled back to the cell surface, or they can move through the late endosome to the lysosome for proteolytic degradation. The sorting of receptors in the early endosome for degradation requires the tyrosine kinase activity of activated growth factor receptor and involves ubiquitination of the receptor. Targeting of receptors for degradation requires members of the Cbl gene family. Cbl proteins bind to tyrosine phosphorylated EGF receptor, and are E3 ubiquitination ligases that label receptor for degradation. Cbl also recruits Cin85 to the receptor complex, and blocking Cin85 interaction blocks receptor internalization and degradation. Endophilins are also a member of this receptor-bound protein complex. In its role as a ubiquitin ligase and docking protein, Cbl desensitizes EGF signaling and also opposes cellular proliferation induced by EGF. EGF activation also appears to activate the tyrosine kinase Src, which phosphorylates Cbl, and helps to activate the ubiquitination and degradation of EGF receptor. PKC activation and threonine phosphorylation of the EGF receptor can induce heterologous receptor internalization, but opposes Cbl-mediated receptor degradation. PKC phosphorylated receptors are sorted for recycling to the cell surface, and directed away from the late endosome and proteasome. Other growth factor receptors are regulated in a similar manner, including the PDGF receptor, HGF receptor and the CSF-1 receptor, indicating that this is a fairly general regulatory mechanism. The importance of Cbl in the down-regulation of growth factor signaling means that it will have …
MCID: MC00523740
PMOID: PMO:00014734
Subclass_of: Regulatory Pathway
Synonym: CBL mediated ligand-induced downregulation of EGF receptors
Tree Number: T4.8.17
database_cross_reference: NCI:C39016
database_cross_reference: NCI_BioC:C39016

eIF2 Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi and transfers the Met-tRNA to the 40S subunit, to form the 43S preinitiation complex. Later in the cycle, prior to elongation, the bound GTP is hydrolyzed, releasing eIF-2-GDP. For eIF-2 to promote another round of initiation, GDP must be exchanged for GTP, a reaction catalyzed by eIF-2B. Kinases activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), and hemin deficiency (HRI) can phosphorylate the a subunit of eIF-2. This phosphorylation stabilizes the eIF-2-GDP-eIF-2B complex, inhibiting the turnover of eIF-2B. eIF-2B is also inhibited by GSK-3b phosphorylation. These events result in a shut-down of cellular protein synthesis and can lead to apoptosis. (This definition may be outdated - see the DesignNote.)
MCID: MC00525685
PMOID: PMO:00014735
Subclass_of: Regulatory Pathway
Synonym: Regulation of eIF2
Tree Number: T4.8.18
database_cross_reference: NCI:C39061
database_cross_reference: NCI_BioC:C39061

eIF4 Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: eIF-4F and p70 S6 kinase play critical roles in translational regulation. eIF-4F is a complex whose functions include the recognition of the mRNA 5' cap structure (eIF-4E), delivery of an RNA helicase to the 5' region (eIF-4A), bridging of the mRNA and the ribosome (eIF-4G), and circularization of the mRNA via interaction between eIF-4G and the poly(A) binding protein (PABP). Several stimuli, including growth factors and cytokines, regulate the eIF-4 complex and p70 S6 kinase by initiating a phosphorylation cascade involving the sequential activation of PI3-K, PDK1/2, Akt/PKB, and FRAP/mTOR kinase. FRAP/mTOR, together with an unidentified kinase, phosphorylates 4E-BP, leading to its dissociation from and activation of eIF-4E. MNK1/2, activated by ERK and p38 MAPK, phosphorylates and activates eIF-4E. Both processes contribute to the association of eIF-4E and eIF-4G to form the active eIF-4F complex, a necessary component of the 48S initiation complex. Phosphorylation of ribosomal protein S6 by p70 S6 kinase stimulates the translation of mRNAs with a 5' oligopyrimidine tract which typically encode components of the protein synthesis. (This definition may be outdated - see the DesignNote.)
MCID: MC00525686
PMOID: PMO:00014736
Subclass_of: Regulatory Pathway
Synonym: Regulation of eIF4e and p70 S6 Kinase
Synonym: Regulation of eif-4e and p70s6 Kinase
Tree Number: T4.8.19
database_cross_reference: NCI:C39062
database_cross_reference: NCI_BioC:C39062

Estrogen Receptor Regulation by CARM1 Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. The methylation activity of CARM1 modulates the activity of specific transcriptional regulators. CARM1 acts as a coactivator for the myogenic transcription factor Mef2c, and is necessary for normal muscle cell differentiation. The estrogen receptor is another transcription factor that uses CARM1 as one of several coactivators, acting synergistically with CBP through the Grip1 member of the p160 family of coactivators. The interaction of estrogen receptor with various ligand-dependent coactivators may produce the tissue selective response of some estrogen receptor ligands like tamoxifen. (This definition may be outdated - see the DesignNote.)
MCID: MC00526396
PMOID: PMO:00014737
Subclass_of: Regulatory Pathway
Synonym: CARM1 and Regulation of the Estrogen Receptor
Tree Number: T4.8.20
database_cross_reference: NCI:C39013
database_cross_reference: NCI_BioC:C39013

FOXA Transcription Factor Signaling Pathway
type: Class
subclass of: Regulatory Pathway
MCID: MC01393732
PMOID: PMO:00014738
Subclass_of: Regulatory Pathway
Synonym: FOXA transcription factor networks
Tree Number: T4.8.21
database_cross_reference: NCI:C91597
database_cross_reference: NCI_PID:C91597

FOXA1 Transcription Factor Signaling Pathway
type: Class
subclass of: FOXA Transcription Factor Signaling Pathway
MCID: MC01393734
PMOID: PMO:00014739
Subclass_of: FOXA Transcription Factor Signaling Pathway
Synonym: FOXA1 transcription factor network
Tree Number: T4.8.21.1
database_cross_reference: NCI:C91598
database_cross_reference: NCI_PID:C91598

FOXA2 and FOXA3 Transcription Factor Signaling Pathway
type: Class
subclass of: FOXA Transcription Factor Signaling Pathway
MCID: MC01393718
PMOID: PMO:00014740
Subclass_of: FOXA Transcription Factor Signaling Pathway
Synonym: FOXA2 and FOXA3 transcription factor networks
Tree Number: T4.8.21.2
database_cross_reference: NCI:C91599
database_cross_reference: NCI_PID:C91599

FOXM1 Transcription Factor Signaling Pathway
type: Class
subclass of: Regulatory Pathway
MCID: MC01393720
PMOID: PMO:00014741
Subclass_of: Regulatory Pathway
Synonym: FOXM1 transcription factor network
Tree Number: T4.8.22
database_cross_reference: NCI:C91600
database_cross_reference: NCI_PID:C91600

FOXO Transcription Factor Family Signaling Pathway
type: Class
subclass of: Regulatory Pathway
MCID: MC01393721
PMOID: PMO:00014742
Subclass_of: Regulatory Pathway
Synonym: FoxO family signaling
Tree Number: T4.8.23
database_cross_reference: NCI:C91601
database_cross_reference: NCI_PID:C91601

Gap Junction Assembly Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
MCID: MC01394267
PMOID: PMO:00014743
Subclass_of: Regulatory Pathway
Synonym: Gap junction
Tree Number: T4.8.24
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91478
database_cross_reference: NCI_KEGG:C91478

Gene Expression Regulation by Vitamin D Receptor Pathway
type: Class
subclass of: Regulatory Pathway
Definition: A pathway that modulates the expression of genes involved in calcium homeostasis, bone formation, cellular differentiation, cell growth and apoptosis through the direct interaction between the nuclear receptor, vitamin D3 receptor (VDR), primarily as part of a heterodimeric complex with the retinoid X receptor (RXR), and vitamin D response elements (VDREs) found in the promoter regions of vitamin D regulated genes.
MCID: MC00526676
PMOID: PMO:00014744
Subclass_of: Regulatory Pathway
Synonym: Control of Gene Expression by Vitamin D Receptor
Tree Number: T4.8.25
database_cross_reference: NCI:C39263
database_cross_reference: NCI_BioC:C39263

Homeostasis Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: An elaboration of the biological or biochemical events that are involved in the maintenance of the internal physiology of an organism.
MCID: MC01393793
PMOID: PMO:00014745
Subclass_of: Regulatory Pathway
Tree Number: T4.8.26
database_cross_reference: NCI:C91822

Aldosterone-Regulated Sodium Reabsorption Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-term blood pressure. Aldosterone plays a major role in sodium and potassium metabolism by binding to epithelial mineralocorticoid receptors (MR) in the renal collecting duct cells localized in the distal nephron, promoting sodium resorption and potassium excretion. Aldosterone enters a target cell and binds MR, which translocates into the nucleus and regulates gene transcription. Activation of MR leads to increased expression of Sgk-1, which phosphorylates Nedd4-2, an ubiquitin-ligase which targets ENAC to proteasomal degradation. Phosphorylated Nedd4-2 dissociates from ENAC, increasing its apical membrane abundance. Activation of MR also leads to increased expression of Na+/K+-ATPase, thus causing a net increase in sodium uptake from the renal filtrate. The specificity of MR for aldosterone is provided by 11beta-HSD2 by the rapid conversion of cortisol to cortisone in renal cortical collecting duct cells. Recently, besides genomic effects mediated by activated MR, rapid aldosterone actions that are independent of translation and transcription have been documented.
MCID: MC01393843
PMOID: PMO:00014746
Subclass_of: Homeostasis Regulation Pathway
Synonym: Aldosterone-regulated sodium reabsorption
Tree Number: T4.8.26.1
database_cross_reference: NCI:C91503
database_cross_reference: NCI_KEGG:C91503

Angiotensin-converting Enzyme 2 Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Cardiovascular diseases are predicted to be the most common cause of death worldwide by 2020. The major regulator of blood pressure homeostasis is the renin-angiotensin system. Angiotensinogen is digested by renin to produce angiotensin I (AGT I). AGT I is an inactive 10 amino-acid peptide that is further degraded to produce angiotensin II by the angiotensin-converting enzyme (ACE). Angiotensin II is the master regulator of blood pressure increase acting on the heart, kidneys and blood vessels. Angiotensin II causes direct constriction of the resistance vessels and stimulation of the adrenal thereby increasing blood volume and sodium absorption. In 2000, Tipnis et al. discovered ACE 2 a second carboxypeptidase that digests angiotensin. ACE is a di-peptidase, cleaving off 2 peptides from the c-terminal end of angiotensin. ACE 2 only cleaves 1 amino acid to produce angiotensin 1-9 (AGT 1-9) which has no identified function at this time. AGT 1-9 is not converted to angiotensin II but further degraded by ACE to AGT 1-7, a vasodilator. It would appear that ACE 2 inhibits the formation of angiotensin and reduces blood pressure increases. Crackower et al determined that ace2 -/- mice suffered significant heart defects at 6 months. Further deletion of ACE resulted in restored cardiac functions. (This definition may be outdated - see the DesignNote.)
MCID: MC00523073
PMOID: PMO:00014747
Subclass_of: Homeostasis Regulation Pathway
Synonym: Angiotensin-converting enzyme 2 regulates heart function
Tree Number: T4.8.26.2
database_cross_reference: NCI:C38969
database_cross_reference: NCI_BioC:C38969

Bone Mineralization Regulation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs) and by propagating the crystals onto the collagenous extracellular matrix. Two osteoblast proteins, tissue-nonspecific alkaline phosphatase (TNAP) and plasma cell membrane glycoprotein-1 (PC-1) are involved in this process. In the bone matrix, PC-1 is the major producer of PPi, which in turn has an inhibitory effect on hydroxyapatite deposition. TNAP has a positive influence on mineralization primarily by controlling the size of the inhibitory pool of PPi through its inorganic pyrophosphatase activity. TNAP also generates Pi by using NTPs and PPi as substrates, but other more major sources of Pi e.g., intestinal absorption, are likely to contribute the bulk of the Pi needed for hydroxyapatite deposition. (This definition may be outdated - see the DesignNote.)
MCID: MC00523263
PMOID: PMO:00014748
Subclass_of: Homeostasis Regulation Pathway
Synonym: Regulators of Bone Mineralization
Tree Number: T4.8.26.3
database_cross_reference: NCI:C39172
database_cross_reference: NCI_BioC:C39172

Cardiac Muscle Contraction Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
MCID: MC01394312
PMOID: PMO:00014749
Subclass_of: Homeostasis Regulation Pathway
Synonym: Cardiac muscle contraction
Tree Number: T4.8.26.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91467
database_cross_reference: NCI_KEGG:C91467

Circadian Rhythm Pathway BioCarta
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Organisms from flies to humans have daily circadian rhythms entrained with the 24-hour cycle of day and night that regulate many physiological systems. In mammals, there appears to be a master regulator of circadian rhythms in the hypothalamus, as well as additional peripheral mechanisms. The basic framework of the molecular pathways in the cell that produce and maintain these daily rhythms has been elucidated. The central feature of the circadian pathways are two transcription factors, Bmal1 and Clock, that are expressed in a 24 hour cycle and that act together as a heterodimer to regulate the expression of other genes involved in maintaining the circadian rhythm. Bmal1 and Clock activate transcription of multiple Period (per) and Cryptochrome (Cry) genes. When the activity of Bmal1 and Clock is maximal, Per and Cry genes are transcribed, and then translated in the cytoplasm. The translated Per and Cry genes form a complex in the cytoplasm that is transported back into the nucleus. In the nucleus, Per and Cry form a feedback loop that inhibits transcriptional activation by Bmal1 and Clock, lowering their own expression in the process. At the same time, Per and Cry increase transcription of Bmal1 and Clock genes, to initiate the next phase of the cycle once again. This cycle runs autonomously in the cell, causing jet lag during travel, but can be regulated to retrain to changes in the light cycle. Factors that regulate the cycle include casein kinase 1 epsilon (CK1e) that phosphorylates Per2 and induces its degradation. Mutation of PER2 in humans has been genetically linked to changes in human sleep patterns. Further exploration of the factors that regulate circadian rhythms may enable manipulation of the system in sleep disorders. (This definition may be outdated - see the DesignNote.)
MCID: MC01393738
PMOID: PMO:00014750
Subclass_of: Homeostasis Regulation Pathway
Synonym: Circadian Rhythm Pathway 2
Synonym: Circadian Rhythms
Tree Number: T4.8.26.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39030
database_cross_reference: NCI_BioC:C39030

Circadian Rhythm Pathway KEGG
type: Class
subclass of: Homeostasis Regulation Pathway
MCID: MC00529265
PMOID: PMO:00014751
Subclass_of: Homeostasis Regulation Pathway
Synonym: Circadian Rhythm
Tree Number: T4.8.26.6
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38796
database_cross_reference: NCI_KEGG:C38796

Circadian Rhythm Pathway PID
type: Class
subclass of: Homeostasis Regulation Pathway
MCID: MC00815374
PMOID: PMO:00014752
Subclass_of: Homeostasis Regulation Pathway
Synonym: Circadian rhythm pathway
Tree Number: T4.8.26.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91564
database_cross_reference: NCI_PID:C91564

Collecting Duct Acid Secretion Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: One of the important roles of the collecting duct segment of the kidney nephron is acid secretion. As daily food intake loads acid into the body, urinary acid excretion is essential, and urine pH can drop as low as 4.5. The alpha-intercalated cell of collecting duct is the main responsible for hydrogen secretion into the urine. The carbon dioxide, which is generated in the cells and enters from the blood, is changed to carbonic acid. This carbonic acid is divided into hydrogen ion and bicarbonate ion. Intracellular CA II catalyses the formation of these ions. The hydrogen ion is secreted into the lumen by the luminal H(+)-ATPase. The bicarbonate ion is transported to the blood side by the anion exchanger type 1. Hydrogen ion in the lumen is trapped by urinary buffers. These include ammonium and phosphate.
MCID: MC01393672
PMOID: PMO:00014753
Subclass_of: Homeostasis Regulation Pathway
Synonym: Collecting duct acid secretion
Tree Number: T4.8.26.8
database_cross_reference: NCI:C91493
database_cross_reference: NCI_KEGG:C91493

Fibrinolysis Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Clot formation and fibrinolysis is a balance of plasmin activation/inhibition and thrombin-thrombomodulin activity that regulates fibrin polymer formation and degradation. Active thrombin is produced by the cleavage of prothrombin in the intrinsic thrombin activation pathway or the extrinsic thrombin activation pathway. Cleavage of fibrinogen by thrombin releases the fibrin monomers that auto-polymerize within seconds into fibrin threads or fibers. The coagulation cascade has many feedback loops. One example is the binding of thrombin to the fibrin polymers resulting in a reduction in soluble thrombin. The fibers form a more stable clot as a result of the covalent bonds formed by activated factor XIII enzyme (also known as Fibrin-stabilizing factor). These fibers form a mesh that traps platelets, blood cells and plasma to form a clot. The removal of the clot is caused by plasmin cleavage of the fibrin monomers into soluble fibrin degradation products. Plasmin is formed by the cleavage of plasminogen between Arg561 and Val562. Plasmin is a two-chain trypsin-like serine protease. Plasminogen activator inhibitor 1 (PAI1) and plasminogen activator inhibitor 2 (PAI2) inhibit cleavage of plasminogen by tissue-type plasminogen activator (tPA) or urokinase plasminogen activator (uPA). The presence of fibrin fibers and fibrin degradation products [(DD)E1 and (DD)E2] exert a two-fold stimulation of tPA and uPA. Plasmin activity is also inhibited by alpha2-antiplasmin. Thrombin activatable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like proenzyme activated by the thrombin-thrombomodulin dimer. TAFI cleaves (DD)E2 to separate DD and E fragments which do not enhance the activation of tPA or uPA and results in a reduced feedback signal. Overabundance or increased activity of the plasminogen activator inhibitors or reduced presence or function of tPA or uPA can result in atherosclerotic disease and venous thrombosis due to an increase in fibrin deposition or formation o…
MCID: MC00526483
PMOID: PMO:00014754
Subclass_of: Homeostasis Regulation Pathway
Tree Number: T4.8.26.9
database_cross_reference: NCI:C39080
database_cross_reference: NCI_BioC:C39080

Food Intake and Energy Homeostasis Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: The synthesis and release of growth hormone (GH) from the pituitary are controlled by the hypothalamic hormones GH-releasing hormone (GHRH) and somatostatin (SRIF), which in turn are regulated by feedback from blood GH and insulin-like growth factor-I (IGF-I) concentrations. The recently discovered endogenous GH-releasing peptide, called ghrelin, also stimulates GH release. Circulating GH acts directly on many organs to stimulate IGF-I production, with IGF-I production in the liver providing the main source of blood IGF-I. Most of the IGF-I in the circulation is bound to IGF-binding protein-3 (IGFBP-3) in a ternary complex with acid-labile subunit (ALS); a smaller fraction is bound to the five other IGFBP. A small fraction of the total IGF-I in blood is in a bioactive-free fraction. In the kidney, IGF-I increases renal plasma flow and GFR, whereas on bone it acts on the epiphysial plate, which leads to longitudinal bone growth. GH also has direct effects on many organs, including kidney and cartilage, which can be independent of IGF-I action. The GH/IGF-I axis in chronic renal failure (CRF) is changed markedly compared with the normal axis. In CRF, the total concentrations of the hormones in the GH/IGF-I axis are not reduced, but there is reduced effectiveness of endogenous GH and IGF-I, which probably plays a major role in reducing linear bone growth. The reduced effectiveness of endogenous IGF-I likely is due to decreased levels of free, bioactive IGF-I as levels of circulating inhibitory IGFBP are increased. In addition, less IGF-I is circulating in the complex with ALS and IGFBP-3 as a result of increased proteolysis of IGFBP-3. Together, these lead to decreased IGF-I receptor activation and a decreased feedback to the hypothalamus and pituitary. Low free IGF-I and high IGFBP-1 and -2 levels probably contribute to a reduced renal function and lead to a reduced stature. The direct effects of GH on bone, which are poorly understood, also are blunted. (This definit…
MCID: MC00526538
PMOID: PMO:00014755
Subclass_of: Homeostasis Regulation Pathway
Synonym: Ghrelin: Regulation of Food Intake and Energy Homeostasis
Tree Number: T4.8.26.10
database_cross_reference: NCI:C39093
database_cross_reference: NCI_BioC:C39093

Gastric Acid Secretion Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetylcholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+, K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and H+ secretion into the stomach lumen.
MCID: MC01393766
PMOID: PMO:00014756
Subclass_of: Homeostasis Regulation Pathway
Synonym: Gastric acid secretion
Tree Number: T4.8.26.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91811
database_cross_reference: NCI_KEGG:C91811

Hemoglobin Chaperone Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: The function of hemoglobin in oxygen transport by red blood cells requires precise assembly of a tetramer of two beta-subunits and two alpha-units. If too many beta-subunits are present, then all tetramers of beta-subunits are formed that bind oxygen but do not release it when needed. When alpha-subunits are in excess they form precipitates with oxidized heme that damage red blood cells. Red blood cells require a precise coregulation of alpha and beta subunit expression to maintain the proper ratio of the subunits and normal red blood cell function. Generally red blood cells express slightly more alpha than beta-subunits to avoid forming unproductive beta-tetramers (HbH). The slight excess of alpha units are blocked from precipitation by a molecular chaperone, AHSP, alpha-hemoglobin stabilizing protein. Expression of the AHSP gene is coordinately activated with the globin genes and heme biosynthesis genes by the GATA-1 gene involved in erythrocyte differentiation. AHSP blocks precipitation of alpha-units, and promotes the formation of normal productive alpha-beta tetramers (HbA). People with mutation or deletion of the beta-subunit gene have Beta-thalassemias resulting from an over-abundance of alpha subunits and their precipitation. The severity of the phenotype may depend on the AHSP genotype of these individuals and elevating AHSP levels through gene therapy may provide a treatment strategy for beta-thalassemia. (This definition may be outdated - see the DesignNote.)
MCID: MC00523896
PMOID: PMO:00014757
Subclass_of: Homeostasis Regulation Pathway
Synonym: Hemoglobin's Chaperone
Tree Number: T4.8.26.12
database_cross_reference: NCI:C38976
database_cross_reference: NCI_BioC:C38976

HSP27 Regulation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through necrotic or apoptotic cell death, while increased expression and phosphorylation of heat shock proteins such as Hsp27 can protect cells against cellular stress. Heat shock proteins commonly exhibit molecular chaperone activity and also interact with a wide variety of proteins to exert specific effects. The small heat shock protein Hsp27 exists as monomers, dimers, and oligomers in the cell, and each form has distinct activities. Oligomers are the main form of Hsp27 with molecular chaperone activity and are disrupted by phosphorylation of Hsp27 to form dimers and monomers. S-thiolation of Hsp27 on cysteine also dissociates oligomers and may provide another route of regulating the action of Hsp27 in stress. Map kinase cascades mediate Hsp27 phosphorylation. Heat stress activates the p38 kinase cascade and induces phosphorylation of Hsp27 by the downstream Map kinases Mapkapk2 and Mapkap3. Cytokines such as TNF and IL-1 can also induce Hsp27 phosphorylation through this Map kinase cascade, protecting cells in some settings against cytotoxic responses. In stressful conditions, dissociation of oligomeric Hsp27 by phosphorylation may allow lower molecular weight forms to perform other non-chaperone functions. One action of Hsp27 induced by stress is to protect cells against apoptosis and a common component of apoptotic pathways is the mitochondrial release of cytochrome c. One way that Hsp27 reduces apoptosis is by preventing the release of cytochrome c and by binding to cytochrome c in the cytosol. Downstream, Hsp27 also blocks caspase 9 activation and the subsequent activation of caspase 3, inhibiting the rest of the proteolytic caspase cascade. Yet a further role of Hsp27 in blocking apoptosis is through blocking Fas-induced apoptosis. Fas is a receptor in the TNF receptor gene family that induces apoptosis when stimulated b…
MCID: MC00523875
PMOID: PMO:00014758
Subclass_of: Homeostasis Regulation Pathway
Synonym: Stress Induction of HSP Regulation
Tree Number: T4.8.26.13
database_cross_reference: NCI:C39108
database_cross_reference: NCI_BioC:C39108

Hypoxia-Inducible Factor Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Hypoxia (or low O2 levels) affects various pathologies. First, tissue ischemia, a variation in O2 tension caused by hypoxia/reoxygenation, can lead to endothelial cell changes. For example, long periods of ischemia result in endothelial changes, such as vascular leakage, resulting in varicose veins. In more severe situations, ischemia can lead to myocardial or cerebral infarction and retinal vessel occlusion. Of interest, HIF-1 is stabilized prior to induction of vascular endothelial growth factor (VEGF) expression during acute ischemia in the human heart. Second, pulmonary hypertension associated with chronic respiratory disorders results from persistent vasoconstriction and vascular remodeling. Third, hypoxic gradients created in enlarging solid tumors trigger expression of genes containing hypoxia response elements (HREs) such as those involved in angiogenesis. This allows subsequent delivery of O2, nutrients, and further tumor growth. Vascular remodeling is an important component to tumorigenesis; without proper blood supply, delivery of oxygen may occur by diffusion, but becomes inefficient in tumors greater than 1 mm in diameter. Short-term hypoxia can also elevate platelet numbers, while prolonged exposure may cause some degree of thrombocytopenia in response to increased levels of erythropoietin (EPO). Another disorder involving inadequate responses to hypoxia is preeclampsia, a pathology of pregnancy thought to be caused by improper differentiation of placental trophoblast cells due to poorly controlled O2 tension or improper hypoxia-inducible factor (HIF)-mediated responses. The primary molecular mechanism of gene activation during hypoxia is through HIF-1. Several genes involved in cellular differentiation are directly or indirectly regulated by hypoxia. These include EPO, LDH-A, ET-1, transferrin, transferrin receptor, VEGF, Flk-1, Flt-1, platelet-derived growth factor-beta (PDGF-b), basic fibroblast growth factor (bFGF), and others genes affecting glyco…
MCID: MC00523991
PMOID: PMO:00014759
Subclass_of: Homeostasis Regulation Pathway
Synonym: Hypoxia-Inducible Factor in the Cardiovascular System
Tree Number: T4.8.26.14
database_cross_reference: NCI:C39105
database_cross_reference: NCI_BioC:C39105

Ion Channels in Vascular Endothelium Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Endothelial cells (EC) form a multifunctional signal-transducing surface that performs different tasks dependent on its localization in the vessel tree. Arterial EC provide a pathway for delivery of oxygen from blood to tissue. They modulate the tone of vascular smooth muscle cells, which in turn controls blood pressure and blood flow by adjusting the caliber of arteries and arterioles. In the microvascular bed, EC regulate the permeation of various metabolites, macromolecules, and gases, as well as autocrine and paracrine factors and are involved in the regulation of cell nutrition. In all vessel types, EC are involved in blood coagulation, control of the transport between blood and tissue, movement of cells adhering to EC, wound healing, and angiogenesis. Other functions require an active response of EC to various signals of mechanical, chemical, or neuronal nature. This signal transduction is impaired during vessel disease (arteriosclerosis) and injury, inflammation, or hemodynamic disturbances (hypertension). The role of ion channels in the transduction of these signals into cellular responses is still a matter of debate and has received substantial attention only in the last few years. Our current knowledge is limited to effects of ion channels on fast endothelial responses, these channels being mainly essential for the regulation of Ca2+ signaling. Here we illustrate the negative feedback of cyclic nucleotides (CNG)-induced membrane depolarization on Ca2+ entry. Ca2+ entry via receptor-activated cation channels (RACC) and/or store-operated or capacitative (SOC) elevates [Ca2+]i and stimulates endothelial nitric oxide synthase (eNOS). The subsequent activation of soluble guanylate cyclase (sGC) increases cGMP. cGMP and cAMP, via agonist activation of G protein-coupled receptors (GPCRs), Gs, and adenylate cyclase (AC), activate CNG and/or nonselective cation channels (HCN) channels, which induce membrane depolarization. This depolarization exerts a negative feed…
MCID: MC00526705
PMOID: PMO:00014760
Subclass_of: Homeostasis Regulation Pathway
Synonym: Ion Channels and Their Functional Role in Vascular Endothelium
Tree Number: T4.8.26.15
database_cross_reference: NCI:C39209
database_cross_reference: NCI_BioC:C39209

Long-Term Depression Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization.
MCID: MC01394298
PMOID: PMO:00014761
Subclass_of: Homeostasis Regulation Pathway
Synonym: Long-term depression
Tree Number: T4.8.26.16
database_cross_reference: NCI:C91463
database_cross_reference: NCI_KEGG:C91463

Long-Term Potentiation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII). Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
MCID: MC01394273
PMOID: PMO:00014762
Subclass_of: Homeostasis Regulation Pathway
Synonym: LTP Pathway
Synonym: Long-term potentiation
Tree Number: T4.8.26.17
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91482
database_cross_reference: NCI_KEGG:C91482

Longevity Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: A demonstrated means to increase lifespan in a wide range of organisms is through the restriction of caloric intake. Reducing the consumption of calories increases the lifespan of many different organisms, including mice. Caloric restriction not only increases lifespan, but decreases age-related deterioration of systems and physiological responses, reducing age related diseases like cancer and neurodegenerative disease. Although caloric restriction has not been demonstrated experimentally to increase human lifespan, short-term changes in physiological measures like insulin responsiveness have been observed. Caloric restriction in animals reduces the levels of plasma glucose and insulin and reduces inflammatory responses and may reduce oxidative stress through reduced oxidative metabolism, further contributing to the health benefits of reduced calorie intake. The reduction in inflammation may be related to reduced plasma glucose and in humans could reduce an inflammation connection to cancer, heart disease, and Alzheimer's disease. Genetic analysis has indicated several genes that influence lifespan, particularly those that alter pituitary development, reduce growth hormone secretion, reduce food intake, and reduce apoptosis (p66 Shc). All of these appear to converge on an IGF-1 receptor pathway and to reproduce many of the effects of caloric restriction. Although dwarf mice with defective growth hormone or IGF-1 signaling also have significantly increased lifespan, humans with defects in growth hormone signaling tend to develop diseases that shorten their lifespan. One of the downstream actions of IGF-1 signaling is to repress stress resistance proteins including antioxidant enzymes like superoxide dismutase and heat shock proteins, so a reduction in IGF signaling may extend lifespan by increasing the expression of stress resistance genes. The link between caloric restriction and IGF signaling may be the increased expression of stress resistance proteins. In additio…
MCID: MC00526919
PMOID: PMO:00014763
Subclass_of: Homeostasis Regulation Pathway
Synonym: The IGF-1 Receptor and Longevity
Tree Number: T4.8.26.18
database_cross_reference: NCI:C39141
database_cross_reference: NCI_BioC:C39141

Mucosal Healing Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Maintaining the integrity of the gastrointestinal tract despite the continual presence of microbial flora and injurious agents is essential. Epithelial repair requires restitution and regeneration. During restitution, epithelial cells spread and migrate across the basement membrane to re-establish surface-cell continuity, a process that is independent of cell proliferation. Epithelial continuity depends on a family of small abundant secreted proteins, the trefoil factors (TFFs). The trefoil factor (TFF) family comprises the gastric peptides pS2/TFF1 and spasmolytic peptide (SP)/TFF2, and the intestinal trefoil factor (ITF)/TFF3. Their fundamental action is to promote epithelial-cell restitution within the gastrointestinal tract. TFFs are abundantly secreted onto the mucosal surface by mucus-secreting cells. Their expression is rapidly and coordinately upregulated at the margins of mucosal injury. Secreted TFF acts on adjacent mucosal cell populations either extracellularly (augmenting barrier function) or intracellularly (transcriptional and signaling events). TFF response elements in TFF gene promoters allow increases in TFF expression through auto-induction and cross-induction of other TFFs, in addition to mucin expression and possibly tumor suppression. Cell migration is the result of integrated disruption of cell-cell and cell-substratum adhesion and prevention of apoptosis through cell detachment. Epithelial movement therefore requires integration of motogenic and cell-survival signals. This is achieved by activation of several intracellular signaling pathways that converge on ERK/MAPK and possibly NF-B activation. Serine phosphorylation of the extracellular signal-regulated kinases (ERKs)/mitogen-activated protein kinases (MAPKs) 1 and 2 is central to trefoil factor-mediated signaling, lying downstream of EGFR activation and possibly FAK activation (through recruitment of GRB2 and SOS). Cell migration might result from cooperation between ERK/MAPKs and Rho pro…
MCID: MC01394135
PMOID: PMO:00014764
Subclass_of: Homeostasis Regulation Pathway
Synonym: Trefoil Factors Initiate Mucosal Healing
Tree Number: T4.8.26.19
database_cross_reference: NCI:C39250
database_cross_reference: NCI_BioC:C39250

Myosin Phosphatase Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: The phosphorylation of myosin affects its role in smooth muscle contraction, platelet formation, and possibly other processes. Phosphorylation by myosin light chain kinase (MLCK) increases myosin activity and dephosphorylation by myosin phosphatase decreases myosin activity. CPI, a factor that binds to and inhibits myosin phosphatase, is a target of phosphorylation by PKC and PKN. The inhibitory activity of CPI is regulated by its own phosphorylation state; when CPI is phosphorylated, its inhibitory activity is increased. The activation of signal transduction cascades such as GPCR pathways can lead to activation of PKC, phosphorylation of CPI, inhibition of myosin phosphatase, increased myosin phosphorylation, and increased smooth muscle contraction or platelet release. The action of histamine in vasoconstriction, for example, may be mediated by activation of PKC through the histamine receptor, resulting in phosphorylation of CPI-17, increased inhibition of myosin phosphatase, and increased smooth muscle contraction. (This definition may be outdated - see the DesignNote.)
MCID: MC00524560
PMOID: PMO:00014765
Subclass_of: Homeostasis Regulation Pathway
Synonym: Myosin Pathway
Synonym: PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
Tree Number: T4.8.26.20
database_cross_reference: NCI:C39160
database_cross_reference: NCI_BioC:C39160

Oxidative Stress Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Reactive oxygen species (ROS) are detrimental to cellular health and can damage biological macromolecules. Electrophilic compounds, xenobiotics and antioxidants are sources of reactive oxygen species, creating oxidative stress that can harm cells. Enzymes involved in the Phase II detoxification of xenobiotics to reduce cellular stress include glutathione transferases, quinone reductase, epoxide hydrolase, heme oxygenase, UDP-glucuronosyl transferases, and gamma-glutamylcysteine synthetase. Expression of these genes protects cells from oxidative damage and can prevent mutagenesis and cancer. Transcription of these enzymes is coordinately regulated through antioxidant response elements (AREs). Nrf2 (NF-E2-related factor 2) and Nrf1 are transcription factors that bind to AREs and activate these genes. Inactive Nrf2 is retained in the cytosol by association a complex with the cytoskeletal protein Keap1. Cytosolic Nrf2 is phosphorylated and translocates into the nucleus in response to protein kinase C activation and Map kinase pathways. In the nucleus, Nrf2 activate genes through AREs by interacting with transcription factors in the bZIP family, including CREB, ATF4 and fos or jun. Nrf2 activation of genes is opposed by small maf proteins, including MafG and MafK, maintaining a counterbalance to Nrf2 and balancing the oxidation level of the intracellular environment. (This definition may be outdated - see the DesignNote.)
MCID: MC00527319
PMOID: PMO:00014766
Subclass_of: Homeostasis Regulation Pathway
Synonym: Oxidative Stress Induced Gene Expression Via Nrf2
Tree Number: T4.8.26.21
database_cross_reference: NCI:C38990
database_cross_reference: NCI_BioC:C38990

Platelet Aggregation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Eph kinases are a family of receptor tyrosine kinases with an extracellular domain that binds their ligand, the ephrins, and an intracellular kinase domain. The ephrins are also expressed on the cell surface, so that interaction between Eph kinases and ephrins occurs at the interface between neighboring cells. Binding of ephrins to Eph kinases stimulates signaling in both directions across the interface between cells, in both the receptor expressing and the ligand expressing cells. Eph kinases and ephrins are involved in several biological processes, and their role in neuronal development has been extensively examined. Both Eph kinases (EphA4 and EphB1) and ephrins (ephrinB1) are expressed on platelets, suggesting that activation of eph kinases by ephrins may play a role in clotting when platelets are brought into close proximity in the developing clot. Platelet activation progresses in stages with an early stage that is stimulated by soluble factors like ADP acting through GPCRs and is reversible and later stages with stronger interaction between platelets that may require interaction between Eph kinases and ephrins. One of the molecular targets of signaling by Eph kinases and ephrins is the actin cytoskeleton, which also plays a role in platelet activation. Clustering Eph kinases or ephrins in platelets stimulated cytoskeletal changes as well as other markers of platelet activation during clotting such as secretion of alpha-granules to release clotting factors. Clustering ephrins together activated Rap1b, a ras gene family member that may regulate integrins. Platelet activation caused Eph kinases to bind to src family members Fyn and Lyn and also with the cell adhesion molecule L1. Failure of the ephrins/Eph kinase pathway to function normally in platelets may result in loosely associated platelets and improper clot formation. Eph kinases and ephrins are also expressed on the vascular wall by endothelial cells, suggesting that signaling by these proteins may also …
MCID: MC00524791
PMOID: PMO:00014767
Subclass_of: Homeostasis Regulation Pathway
Synonym: Eph Kinases and ephrins support platelet aggregation
Tree Number: T4.8.26.22
database_cross_reference: NCI:C39065
database_cross_reference: NCI_BioC:C39065

Platelet Amyloid Precursor Protein Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: The amyloid-beta peptide (Ab), a proteolytic fragment of amyloid precursor protein (APP), is the major component of senile plaques, the hallmark of Alzheimer's disease. Platelets contain both APP and Ab and probably contribute greater than 90% of circulating APP. The soluble APP is the major inhibitor of coagulation factors IXa and XIa, and platelet aggregation. Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules. These important molecules released from platelets are key regulators of hemostasis, the physiologic arrest of hemorrhage at site of vascular leakage. (This definition may be outdated - see the DesignNote.)
MCID: MC00524792
PMOID: PMO:00014768
Subclass_of: Homeostasis Regulation Pathway
Tree Number: T4.8.26.23
database_cross_reference: NCI:C39191
database_cross_reference: NCI_BioC:C39191

Proximal Tubule Bicarbonate Reclamation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: One of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "new HCO3(-)" for regulating blood pH. In the tubular lumen, filtered HCO3(-) combines with H(+) in a reaction catalyzed by CA IV. The CO2 thus produced rapidly diffuses into the tubular cells and is combined with water to produce intracellular H(+) and HCO3(-), catalyzed by soluble cytoplasmic CA II. HCO3(-) is then cotransported with Na(+) into blood via the NBC-1. The intracellular H(+) produced by CA II is secreted into the tubular lumen predominantly via the NHE-3. The PT creates the "new HCO3(-)" by taking glutamine and metabolizing it to two molecules each of NH4(+) and HCO3(-). The NH4(+) is excreted into the tubular lumen, and the HCO3(-), which is "new HCO3(-)," is returned to the blood, where it replaces the HCO3(-) lost earlier in the titration of nonvolatile acids.
MCID: MC01393675
PMOID: PMO:00014769
Subclass_of: Homeostasis Regulation Pathway
Synonym: Proximal tubule bicarbonate reclamation
Tree Number: T4.8.26.24
database_cross_reference: NCI:C91494
database_cross_reference: NCI_KEGG:C91494

Renin-Angiotensin Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
MCID: MC01394248
PMOID: PMO:00014770
Subclass_of: Homeostasis Regulation Pathway
Synonym: Renin-angiotensin system
Tree Number: T4.8.26.25
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91434
database_cross_reference: NCI_KEGG:C91434

Salivary Secretion Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP.
MCID: MC01393765
PMOID: PMO:00014771
Subclass_of: Homeostasis Regulation Pathway
Synonym: Salivary secretion
Tree Number: T4.8.26.26
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91810
database_cross_reference: NCI_KEGG:C91810

Vascular Smooth Muscle Contraction Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
MCID: MC00697366
PMOID: PMO:00014772
Subclass_of: Homeostasis Regulation Pathway
Synonym: Vascular smooth muscle contraction
Synonym: vascular smooth muscle contraction
Tree Number: T4.8.26.27
database_cross_reference: GO:GO:0014829
database_cross_reference: NCI:C91523
database_cross_reference: NCI_KEGG:C91523

Vasopressin-Regulated Water Reabsorption Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again.
MCID: MC01394262
PMOID: PMO:00014773
Subclass_of: Homeostasis Regulation Pathway
Synonym: Vasopressin-regulated water reabsorption
Tree Number: T4.8.26.28
database_cross_reference: NCI:C91485
database_cross_reference: NCI_KEGG:C91485

Vitamin C in Brain Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
Definition: Vitamin C (ascorbic acid) was first identified by virtue of the essential role it plays in collagen modification, preventing the nutritional deficiency scurvy. Vitamin C acts as a cofactor for hydroxylase enzymes that post-translationally modify collagen to increase the strength and elasticity of tissues. Vitamin C reduces the metal ion prosthetic groups of many enzymes, maintaining activity of enzymes, and also acts as an anti-oxidant. Although the prevention of scurvy through modification of collagen may be the most obvious role for vitamin C, it is not necessarily the only role of vitamin C. Svct1 and Svct2 are ascorbate transporters for vitamin C import into tissues and into cells. Both of these transporters specifically transport reduced L-ascorbic acid against a concentration gradient using the intracellular sodium gradient to drive ascorbate transport. Svct1 is expressed in epithelial cells in the intestine, upregulated in cellular models for intestinal epithelium and appears to be responsible for the import of dietary vitamin C from the intestinal lumen. The vitamin C imported from the intestine is present in plasma at approximately 50 uM, almost exclusively in the reduced form, and is transported to tissues to play a variety of roles. Svct2 imports reduced ascorbate from the plasma into very active tissues like the brain. Deletion in mice of the gene for Svct2 revealed that ascorbate is required for normal development of the lungs and brain during pregnancy. A high concentration of vitamin C in neurons of the developing brain may help protect the developing brain from free radical damage. The oxidized form of ascorbate, dehydroascorbic acid, is transported into a variety of cells by the glucose transporter Glut-1. Glut-1, Glut-3, and Glut-4 can transport dehydroascorbate, but may not transport significant quantities of ascorbic acid in vivo. (This definition may be outdated - see the DesignNote.)
MCID: MC00527968
PMOID: PMO:00014774
Subclass_of: Homeostasis Regulation Pathway
Synonym: Vitamin C in the Brain
Tree Number: T4.8.26.29
database_cross_reference: NCI:C39267
database_cross_reference: NCI_BioC:C39267

hSWI-SNF Pathway
type: Class
subclass of: Regulatory Pathway
Definition: The eukaryotic genome is packaged by histone and nonhistone proteins to form chromatin. The assembly of nucleosomes, as well as compaction of nucleosomal arrays into higher-order chromatin structures, creates a highly restrictive environment for nuclear processes that require access to DNA. The packaging of eukaryotic DNA into nucleosomes inhibits the access of factors to DNA and thus results in the repression of transcription, replication, and recombination. To counterbalance the repressive nature of chromatin, a variety of chromatin remodeling factors use the energy of ATP hydrolysis to facilitate the interaction of proteins with nucleosomal DNA. ATP dependent chromatin remodeling complexes are characterized by the presence of an ATPase subunit from the SNF2-like family of the DEAD/H (SF2) DNA-stimulated ATPases. The highly conservative hSWI/SNF multisubunit complexes contain hBRM or BRG1 ATPases which alter the histone-DNA contacts enabling the access of general transcription factors to promoter regions. Remodeling complexes are targeted to promoters via interactions with sequence-specific transcription factors. Since chromatin constitutes a barrier for processes affecting DNA, such a transcription, replication, and repair, a mechanism is required that can open up or remodel chromatin to make it accessible to replication and transcription factors. Steroid receptors are a class of transcription factors that can interact with the repressive chromatin structure and remodel the chromatin to allow other transcription factors to bind. In addition to nuclear receptors, transcription activators as divergent as erythroid Kruppel-like factor, C/EBPs, c-Myc, MyoD, HSF1, and EBNA2 have also been found to recruit SWI/SNF to specific promoters. The role of steroid receptors in chromatin remodeling and transcription is exemplified by the glucocorticoid receptor (GR)-mediated transactivation of the mouse mammary tumor virus (MMTV) promoter. The MMTV promoter is organized into a …
MCID: MC00525709
PMOID: PMO:00014775
Subclass_of: Regulatory Pathway
Synonym: Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes
Tree Number: T4.8.27
database_cross_reference: NCI:C39109
database_cross_reference: NCI_BioC:C39109

Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway
type: Class
subclass of: Regulatory Pathway
MCID: MC01393654
PMOID: PMO:00014776
Subclass_of: Regulatory Pathway
Synonym: Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Tree Number: T4.8.28
database_cross_reference: NCI:C91609
database_cross_reference: NCI_PID:C91609

HIF-1-Alpha Transcription Factor Pathway
type: Class
subclass of: Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway
MCID: MC01393655
PMOID: PMO:00014777
Subclass_of: Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway
Synonym: HIF-1-alpha transcription factor network
Tree Number: T4.8.28.1
database_cross_reference: NCI:C91610
database_cross_reference: NCI_PID:C91610

IFN-Beta Enhancer Pathway
type: Class
subclass of: Regulatory Pathway
Definition: The packaging of eukaryotic DNA into nucleosomes inhibits the access of factors to DNA and results in the repression of transcription, replication, and recombination. Local modification of histones on enhancers and promoters is required to activate gene expression. The transcription factors that bind to nucleosome-free regions of DNA or to DNA within nucleosomes recruit two types of enzymatic activities that modify the surrounding chromatin architecture. Chromatin remodeling machines, such as SWI/SNF complex, alter the structure of the pronucleosome in an ATP-dependent manner, and often cause nucleosome sliding. The second type of chromatin modifying complexes recruited by transcription factors covalently modify the N-terminal tails of histones by adding or removing phosphate, methyl, or acetyl groups. Virus-induced transcription of the human interferon-beta gene illustrates one of the best-characterized examples of the mechanisms by which the information contained in the DNA is transferred to the histone-N termini by generating novel adhesive surfaces required for the recruitment of transcription complexes. Upon virus infection, the gene is switched on by three transcription factors (NF-kB, IRFs, and ATF-2/c-Jun), and an architectural protein (HMG I(Y)), all of which bind cooperatively to the nucleosome-free enhancer DNA to form an enhanceosome. The enhanceosome targets the modification and repositioning of a nucleosome that blocks the formation of a transcriptional preinitiation complex on the IFN-beta promoter. This is accomplished by the ordered recruitment of HATs, SWI/SNF, and basal transcription factors. Initially, the PCAF HAT-containing complex is recruited, and it acetylates the nucleosome. This is followed by the recruitment of the CBP-PolII holoenzyme complex. The bromodomain containing transcription complexes SWI/SNF and TFIID are recruited to the promoter via bivalent interactions between the enhanceosome and specifically acetylated histone N termini. …
MCID: MC00523995
PMOID: PMO:00014778
Subclass_of: Regulatory Pathway
Synonym: The information-processing pathway at the IFN-beta enhancer
Tree Number: T4.8.29
database_cross_reference: NCI:C39183
database_cross_reference: NCI_BioC:C39183

Immune Response Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: An elaboration of the sequence of events that play a role in organismal defense responses.
MCID: MC01394085
PMOID: PMO:00014779
Subclass_of: Regulatory Pathway
Tree Number: T4.8.30
database_cross_reference: NCI:C39698

4-1BB-Dependent Immune Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The activation of T cells requires a co-stimulatory signal with T cell receptor activation, provided in many cases by activation of CD28 in resting T cells. 4-1BB (CD137) is a member of the TNF receptor gene family that provides another T cell co-stimulatory signal. 4-1BB is expressed by activated cytotoxic and helper T cells and its expression is induced by a variety of T cell stimuli, including activation of the T cell receptor or stimulation with mitogens. The ligand for 4-1BB (4-1BBL) is induced on activated antigen-presenting cells including macrophages, activating T cells expressing 4-1BB. Mice lacking 4-1BB survive and have an altered though functional immune response. T cells of mice lacking 4-1BB proliferate more rapidly than normal T cells, but have reduced cytokine secretion. The costimulatory signal provided by 4-1BB may act in combination with CD28 activation to prolong the T cell response, and may also act independently of CD28. Stimulation of T cells with the 4-1BB ligand may provide a therapeutic immune response in the treatment of cancer or viral infection. 4-1BB in T cells activates several signaling pathways. Like other members of the TNF receptor family, the 4-1BB receptor does not have an intrinsic kinase activity. TRAF2 is a signaling adapter that mediates signaling by other members of the TNF receptor family and that also binds to the cytoplasmic domain of ligand activated 4-1BB to activate intracellular kinase cascades. TRAF1 also binds to the cytoplasmic domain of 4-1BB although with lower affinity than TRAF2. One downstream effector activated by 4-1BB through TRAF2 is the transcription factor NF-kB. 4-1BB also activates map kinase pathways, including p38 and JNK activation. ASK1 dependent pathways can activate both p38 and JNK, and dominant negative ASK1 blocks their activation. Other kinase pathways may also be involved in 4-1BB activation of p38 and JNK, such as activation of germinal center kinase (GCK) or related kinases involved in act…
MCID: MC01393777
PMOID: PMO:00014780
Subclass_of: Immune Response Regulation Pathway
Synonym: The 4-1BB-dependent immune response
Tree Number: T4.8.30.1
database_cross_reference: NCI:C39277
database_cross_reference: NCI_BioC:C39277

Adhesion Molecules on Lymphocyte Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: B cell and T cell lymphocytes interact with a variety of cells as part of their immune function, circulating and homing in on specific stimuli in tissues like inflammatory signals. The interaction of lymphocytes with other cell types like vascular endothelial cells requires transmembrane adhesion molecules like VLA-4, LFA-1, CD44, CD31 and L-selectin. Each of these lymphocyte adhesion molecules interacts with specific ligands expressed on cells like endothelial cells to moderate adhesion between cells. CD44 is an adhesion molecule with many roles, including interaction of leukocytes with endothelial cells in response to inflammation, with the most often studied ligand being hyaluronan, a component of the extracellular matrix. LFA-1, Leukocyte function-associated molecule 1, is an integrin composed of two subunits, CD11a and CD18. LFA-1 moderates adhesion of lymphocytes with other cells and also transduces signals into cells through interaction with ICAM-1 expressed on endothelial cells. Expression of ICAM-1 (CD54) is increased by inflammatory signals, increasing adhesion and permeation of lymphocytes into inflamed tissues. VLA-4 is another integrin expressed on lymphocytes that plays a role in adhesion through interaction with its adhesion partner on endothelial cells, VCAM-1. L-selectin appears to mediate adhesion through binding of a lectin-like domain to carbohydrates. PECAM-1 (CD31) is expressed on endothelial cells and is involved in angiogenesis as well as adhesion between cells. VAP-1 is an additional protein expressed by lymphocytes and involved in adhesion to vascular endothelial cells. (This definition may be outdated - see the DesignNote.)
MCID: MC01394144
PMOID: PMO:00014781
Subclass_of: Immune Response Regulation Pathway
Synonym: Adhesion Molecules on Lymphocyte
Tree Number: T4.8.30.2
database_cross_reference: NCI:C91303
database_cross_reference: NCI_BioC:C91303

Allergy Chemokine Network Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The inflammatory response associated with asthma is characterized by the recruitment of eosinophils from the bronchial microcirculation in response to the regulated local production of chemoattractant molecules. Although several chemical mediators are active upon eosinophils in vitro, a central role in eosinophil accumulation in vivo is emerging for the C-C chemokine eotaxin, which was first identified in a guinea pig model of allergic airway inflammation using protein purification and microsequencing. Eotaxin is the dominant eosinophil-selective chemoattractant in this model, acting to cause both local eosinophil recruitment to the lung, and the release of a rapidly mobilizable pool of bone marrow eosinophils in cooperation with IL-5. Eotaxin and eotaxin-2 are potent stimulators of eosinophils, signaling exclusively via high affinity binding to the receptor CCR3. C-C chemokines, including MCP-3, MCP-4, and RANTES, also stimulate eosinophils via CCR3, although they show less leukocyte selectivity as they additionally signal via other chemokine receptors expressed on a range of leukocytes, including lymphocytes and monocytes. CCR3 is expressed in high numbers on eosinophils and is thought to be the major eosinophil chemokine receptor. Blockade of CCR3 in vivo inhibits eosinophil recruitment in response to eotaxin in both the guinea pig and mouse. More recently, CCR3 expression has been demonstrated on basophils and Th2-type T cells, suggesting possible roles for CCR3 in the genesis and maintenance of allergic inflammation. CCR3 is therefore a major target for anti-inflammatory drug development. (This definition may be outdated - see the DesignNote.)
MCID: MC00523051
PMOID: PMO:00014782
Subclass_of: Immune Response Regulation Pathway
Synonym: The Role of Eosinophils in the Chemokine Network of Allergy
Tree Number: T4.8.30.3
database_cross_reference: NCI:C39064
database_cross_reference: NCI_BioC:C39064

Alternative Complement Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The complement system of plasma proteins is an important part of the immune system that forms a cascade of factors that lyses foreign cells. There are two branches of the complement system, the classical pathway that is initiated by antibody-antigen complexes on a cell and the alternative pathway that is antibody independent. The ultimate result in either pathway is the creation of the membrane attack complex, a large pore in the cell membrane that results in cell lysis. The alternative pathway starts with the spontaneous conversion of C3 to an active protease. C3 contains a thioester group that is spontaneously hydrolyzed at a slow rate to create C3(H2O). From there, binding of factor B (Fb) and activation by factor D (Fd) cleaves factor B to create the active protease C3 convertase (AP convertase). This enzyme cleaves C3 to form C3b, which can go on to form a C5 activating convertase. At this point the alternative pathway proceeds in the same manner as the classical pathway, recruiting additional complement factors (C6, C7, C8 and C9) to ultimately form the membrane attack complex and lyse the associated cell. One question about the alternative pathway is how the spontaneous activation of C3 in plasma leads to the lysis of specific cells in the absence of antibody on the cell surface. Active C3b binds to the cell surface, particularly to complement activators like cell wall components and lipopolysaccharide. A constant low level of spontaneous C3b formation ensures that C3b can bind to invading cells and trigger the rest of the alternative complement pathway to lyse the cells even in the absence of an antibody response. The constant low level of C3b activation and potential activation of the alternative pathway is kept in check by a natural damper, factor H and factor I. Factors H and I in plasma inactivate C3b enzyme in solution. Factors H and I cannot inactivate C3b on the cell surface due to protection by properdin, ensuring that the alternative pathway is prim…
MCID: MC00003157
PMOID: PMO:00014783
Subclass_of: Immune Response Regulation Pathway
Synonym: Alternative Complement Activation Pathway
Synonym: C76 COMPLEMENT ACTIVATION ALTERNATIVE PATHWAY
Synonym: COMPLEMENT ACTIVATION ALTERNATIVE PATHWAY
Synonym: Complement Activation Pathway, Alternative
Synonym: Complement Pathway, Alternative
Synonym: Complement activation alternative pathway
Synonym: Complement activation alternative pathway (function)
Synonym: Complement activation alternative pathway, NOS
Synonym: Complement activation alternative pathway, function
Synonym: Complement activation alternative pathway, function (observable entity)
Tree Number: T4.8.30.4
database_cross_reference: CSP:5004-0002
database_cross_reference: GO:GO:0006957
database_cross_reference: MSH:D003170
database_cross_reference: NCI:C38983
database_cross_reference: NCI_BioC:C38983
database_cross_reference: SNMI:F-C7600
database_cross_reference: SNOMEDCT_US:86091003

Antigen Dependent B Cell Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: A key part of the immune system is the production of immunoglobulins (antibodies) by B cells to bind and inactivate specific foreign antigens. The body produces B cells with a wide range of antigen specificities in their immunoglobulin B cell receptor, but each cell only has a single specificity. When the B cell receptor immunoglobulin binds antigen, that cell is activated to proliferate and create plasma cells secreting immunoglobulins to bind that specific antigen. B cell activation also creates memory cells with the same antigen specificity that do not actively secrete immunoglobulin but provide for rapid future immune responses to the same antigen. B cells are not activated by antigen on their own, but require interaction with helper CD4+ T cells to become activated and proliferate. The B cell first expresses immunoglobulin on the cell surface as the B cell receptor. If the B cell receptor immunoglobulin binds specific antigen, then the cell internalizes the antigen and presents it to T cells in MHC II, where it is recognized by the T cell receptor. In addition to the interaction between the T cell receptor and the B cell MHC-antigen, T cell interaction with the B cell involves additional positive and negative regulatory signals. CD40 interaction with CD40L and CD28 interaction with CD80 provide positive costimulatory signals that stimulate B cell activation and proliferation. T cell receptor activation induces expression of molecules like the CD40 ligand that modulate the B cell-T cell interaction. The CD40-CD40L interaction induces cytokine production and expression of other genes and alters the fate of the B cell involved in the interaction. If the interaction between CD40 and CD40L is prolonged, the B cell can be induced to become a memory cell rather than a plasma cell. Fas ligand binding to Fas between B and T cells may negatively modulate B cell activation, inducing apoptosis that limits B cell proliferation and activation. Cytokines like IL-2, IL-4 and I…
MCID: MC00525964
PMOID: PMO:00014784
Subclass_of: Immune Response Regulation Pathway
Synonym: Antigen Dependent B Cell Activation
Tree Number: T4.8.30.5
database_cross_reference: NCI:C38994
database_cross_reference: NCI_BioC:C38994

Antigen Presentation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Invariant chain (Ii) associates with newly synthesized class II molecules in the endoplasmic reticulum (ER), an interaction that has been shown to interfere with peptide binding to class II molecules. The class II-associated invariant chain peptide (CLIP) region (residues 81-104) of Ii is believed to mediate this inhibition by engaging the binding domain of class II like an antigenic peptide. Together, these findings have given rise to a model in which CLIP association with the class II groove acts to prevent inappropriate presentation of peptides imported into the ER for association with major histocompatibility complex class I molecules. (This definition may be outdated - see the DesignNote.)
MCID: MC00525966
PMOID: PMO:00014785
Subclass_of: Immune Response Regulation Pathway
Synonym: Antigen Processing and Presentation
Tree Number: T4.8.30.6
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39153
database_cross_reference: NCI_BioC:C39153

Antigen Processing and Presentation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
MCID: MC00815364
PMOID: PMO:00014786
Subclass_of: Immune Response Regulation Pathway
Synonym: Antigen processing and presentation
Tree Number: T4.8.30.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91433
database_cross_reference: NCI_KEGG:C91433

B Cell Receptor Complex Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: B cells produce immunoglobulins (Ig, antibodies) that specifically bind antigen molecules. B cells first produce a membrane-bound form of immunoglobulin, the B cell receptor, as part of B cell differentiation. Each B cell expresses one immunoglobulin but the population of B cells in each individual display a wide variety of antigen specificity, with each cell expressing Ig on its surface as part of the B cell receptor complex. When the B cell receptor binds to antigen, it initiates a signal through other proteins non-covalently associated with it in the B cell receptor complex, the Ig-alpha (CD79a) and Ig-beta (CD79b) chains. The signal initiated by binding of antigen to the B cell receptor complex causes growth and proliferation of the B cell and the creation of an amplified clone of effector cells that secrete the antigen-specific immunoglobulin. Activation of the B cell receptor by antigen also results in the production of memory cells that persist in circulation to produce a more rapid immune response after future challenges by the same antigen. (This definition may be outdated - see the DesignNote.)
MCID: MC01394323
PMOID: PMO:00014787
Subclass_of: Immune Response Regulation Pathway
Synonym: B Cell Receptor Complex
Tree Number: T4.8.30.8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91309
database_cross_reference: NCI_BioC:C91309

B Cell Receptor Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
MCID: MC00451118
PMOID: PMO:00014788
Subclass_of: Immune Response Regulation Pathway
Synonym: B cell receptor signaling pathway
Synonym: B cell receptor signalling pathway
Synonym: B lymphocyte receptor signaling pathway
Synonym: B lymphocyte receptor signalling pathway
Synonym: B-cell receptor signaling pathway
Synonym: B-cell receptor signalling pathway
Synonym: B-lymphocyte receptor signaling pathway
Synonym: B-lymphocyte receptor signalling pathway
Synonym: BCR Immune Response Signaling Pathway
Synonym: BCR Signaling Pathway
Tree Number: T4.8.30.9
database_cross_reference: GO:GO:0050853
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39005
database_cross_reference: NCI:C91456
database_cross_reference: NCI:C91551
database_cross_reference: NCI_BioC:C39005
database_cross_reference: NCI_KEGG:C91456
database_cross_reference: NCI_PID:C91551

B Lymphocyte Cell Surface Molecule Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: B cells must communicate with their environment to participate in the immune system as the source of antigen-specific immunoglobulins. Cell surface proteins on B cells receive signals from the exterior, adhere to other cells, and transmit signals to other cells. Antigen recognized by a B cell's immunoglobulin is presented in MHC Class II to T cells during B cell activation. Cell surface immunoglobulins are a key to B cell function, assisting in the response of B cells to specific antigen recognized by that cell's immunoglobulin. CD54 (ICAM-1) is an adhesion molecule involved in the binding of B cells to other cell types and LFA-1 is an integrin adhesion protein with two subunits that binds to ICAM. CD35 and CD21 are receptors for complement factors that stimulate the B cell response when complement is activated. CD80 and CD40 bind to T cell proteins (CD28 and CD40L, respectively) to provide costimulatory signals in the B cell-T cell interaction required for B cell activation. CD45 is a protein tyrosine phosphatase that regulates activation of B cells and T cells through dephosphorylation of signaling factors. CD32 is a receptor for IgG Fc, and is also called Fc gamma RII. The number of proteins on the surface of B cell proteins indicates the complexity of regulation of B cell activation. (This definition may be outdated - see the DesignNote.)
MCID: MC01394326
PMOID: PMO:00014789
Subclass_of: Immune Response Regulation Pathway
Synonym: B Lymphocyte Cell Surface Molecules
Tree Number: T4.8.30.10
database_cross_reference: NCI:C91310
database_cross_reference: NCI_BioC:C91310

B-Cell Immune Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: APRIL and BAFF (also called TALL-I and BLyS) are TNF family members that act as ligands for the BCMA and TACI receptors. Both APRIL and BAFF bind to both the BCMA and TACI receptors to activate the humoral immune response, stimulating B cell immunoglobulin production and proliferation. BAFF is found as a membrane bound form in T cells and a soluble form that is released from the cell to stimulate B cell proliferation and differentiation. As members of the TNF receptor gene family, BCMA and TACI interact with TRAF family members to transduce signals downstream to NF-kappaB activation and MAP kinase pathways. Abnormally active BAFF or APRIL signaling may play a role in autoimmune disorders such as lupus. (This definition may be outdated - see the DesignNote.)
MCID: MC00523144
PMOID: PMO:00014790
Subclass_of: Immune Response Regulation Pathway
Synonym: TACI and BCMA stimulation of B cell immune responses
Tree Number: T4.8.30.11
database_cross_reference: NCI:C39243
database_cross_reference: NCI_BioC:C39243

B-Cell Survival Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Physical interactions between integrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignant B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, survivin, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction. (This definition may be outdated - see the DesignNote.)
MCID: MC00523146
PMOID: PMO:00014791
Subclass_of: Immune Response Regulation Pathway
Synonym: B Cell Survival Pathway
Tree Number: T4.8.30.12
database_cross_reference: NCI:C39004
database_cross_reference: NCI_BioC:C39004

BCR Immune Response Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
MCID: MC00451118
PMOID: PMO:00014792
Subclass_of: Immune Response Regulation Pathway
Synonym: B Cell Receptor Signaling Pathway
Synonym: B cell receptor signaling pathway
Synonym: B cell receptor signalling pathway
Synonym: B lymphocyte receptor signaling pathway
Synonym: B lymphocyte receptor signalling pathway
Synonym: B-cell receptor signaling pathway
Synonym: B-cell receptor signalling pathway
Synonym: B-lymphocyte receptor signaling pathway
Synonym: B-lymphocyte receptor signalling pathway
Synonym: BCR Signaling Pathway
Tree Number: T4.8.30.13
database_cross_reference: GO:GO:0050853
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39005
database_cross_reference: NCI:C91456
database_cross_reference: NCI:C91551
database_cross_reference: NCI_BioC:C39005
database_cross_reference: NCI_KEGG:C91456
database_cross_reference: NCI_PID:C91551

Bystander B Cell Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Expression of Fas-Ligand by T cells can induce apoptosis through interaction with Fas on the target cell. A target of Fas-mediated apoptosis is the B cell. B cells that are not activated by antigen, bystander B cells, can interact through CD40 with the CD40 ligand on T cells. The CD40-CD40L interaction induces Fas expression by bystander B cells, and the interaction of Fas with the T cell Fas-Ligand, followed by B cell apoptosis. B cells that are activated by antigen binding and that interact with the T cell receptor through the B cell MHC II appear to become resistant to Fas-mediated apoptosis, survive and proliferate. IL-4 also appears to confer B cell resistance to Fas-mediated apoptosis. The induction of apoptosis in non-antigen stimulated B cells may prevent B cells from proliferating inappropriately and failure of this mechanism may be involved in autoimmune disorders and B cell lymphomas. (This definition may be outdated - see the DesignNote.)
MCID: MC00523334
PMOID: PMO:00014793
Subclass_of: Immune Response Regulation Pathway
Synonym: Bystander B Cell Activation
Tree Number: T4.8.30.14
database_cross_reference: NCI:C39003
database_cross_reference: NCI_BioC:C39003

Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes
type: Class
subclass of: Immune Response Regulation Pathway
MCID: MC01394252
PMOID: PMO:00014794
Subclass_of: Immune Response Regulation Pathway
Synonym: Role of Calcineurin-dependent NFAT signaling in lymphocytes
Tree Number: T4.8.30.15
database_cross_reference: NCI:C91556
database_cross_reference: NCI_PID:C91556

Calcineurin-Regulated NFAT-Dependent Transcription Pathway
type: Class
subclass of: Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes
MCID: MC01393725
PMOID: PMO:00014795
Subclass_of: Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes
Synonym: Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Synonym: Lymphocyte NFAT-Dependent Transcription Pathway
Tree Number: T4.8.30.15.1
database_cross_reference: NCI:C91740
database_cross_reference: NCI_PID:C91740

Chemokine Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
MCID: MC01394265
PMOID: PMO:00014796
Subclass_of: Immune Response Regulation Pathway
Synonym: Chemokine signaling pathway
Tree Number: T4.8.30.16
database_cross_reference: NCI:C91487
database_cross_reference: NCI_KEGG:C91487

Classical Complement Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The complement system is part of the defense against invading cells and is composed of about twenty different proteins found in the plasma. When activated, complement proteins form a pathway of proteolytic reactions that culminates in the lysis of foreign cells. The complement system also stimulates phagocytosis of foreign cells and an inflammatory response. There are two different complement systems, the classical complement pathway initiated by antibody complexes on the cell surface, and an alternative complement pathway that is initiated without antibodies. The complement system proteins are named with a capital C followed by a number. A small letter after the number indicates that the protein is a smaller protein resulting from the cleavage of a larger precursor by a protease. In the classical pathway, the first step is the initiation of the pathway triggered by recognition by complement factor C1 of antigen-antibody complexes on the cell surface. When C1 complex interacts with aggregates of IgG with antigen on a cell's surface, two C1-associated proteases, C1r and C1s, are activated. Other factors like lipopolysaccharide also activate C1s. Once C1s is activated, it cleaves C4 to form C4b that then binds to the cell membrane of the cell being attacked. The proteolytic complement cascade is then amplified on the cell membrane through sequential cleavage of complement factors and recruitment of new factors until a cell surface complex containing C5b, C6, C7, and C8 is formed. The addition of a multiple C9 proteins creates the membrane attack complex results in a large pore that spans the membrane of the cell being attacked, allowing ions to flow freely between the cellular interior and exterior. Ions flow out, but large molecules stay in, causing water to flood into the cell and ultimately burst the cell from osmotic pressure. (This definition may be outdated - see the DesignNote.)
MCID: MC00003158
PMOID: PMO:00014797
Subclass_of: Immune Response Regulation Pathway
Synonym: Classical Complement Activation Pathway
Synonym: Complement Activation Pathway, Classical
Synonym: Complement Pathway, Classical
Synonym: classical complement pathway
Tree Number: T4.8.30.17
database_cross_reference: CSP:5004-0017
database_cross_reference: MSH:D003171
database_cross_reference: NCI:C39032
database_cross_reference: NCI_BioC:C39032

Complement and Coagulation Cascade
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsinization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning.
MCID: MC01393867
PMOID: PMO:00014798
Subclass_of: Immune Response Regulation Pathway
Synonym: Complement and coagulation cascades
Tree Number: T4.8.30.18
database_cross_reference: NCI:C91511
database_cross_reference: NCI_KEGG:C91511

Complement Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The complement pathway consists of a series of over thirty proteins in plasma that are part of the immune response. Activation of the complement system lyses bacterial cells, forms chemotactic peptides (C3a and C5a) attracting immune cells, and increases phagocytotic clearance of infecting cells. Complement can also increase the permeability of vascular walls and cause inflammation. Most complement proteins exist in plasma as inactive precursors that cleave and activate each other in a proteolytic cascade in response to three different mechanisms by which the complement system is activated, the classical pathway, the alternative pathway and the lectin-induced pathway. These three systems are distinct in the initiation of the proteolytic cascade but share most of their components and all three converge in the creation of a C3 convertase that cleaves the C3 complement protein, leading ultimately to the formation of the membrane attack complex, MAC, a pore causing lysis of cells. The classical pathway is activated by the recognition of foreign cells by antibodies bound to the surface of the cells. The alternative and lectin-induced pathways are both antibody independent. Proteolysis is triggered in the alternative pathway by the spontaneous activation of C3 convertase from C3 and is triggered in the lectin-induced pathway by the recognition of carbohydrates on the bacterial cell surface by mannan-binding protein, Mbp. In addition to providing a key part of the response to bacterial infection, the complement system can be involved in the response to fungi, viruses and protists. While activation of the complement system is a key part of the immune system, it must also be kept in check to prevent inappropriate or exaggerated responses. Twelve different proteins have been identified that inhibit complement activation to control the system, including Factor H, Factor I and C1 inhibitor. Deficiencies in components of the complement system have been identified in humans that …
MCID: MC00441608
PMOID: PMO:00014799
Subclass_of: Immune Response Regulation Pathway
Synonym: complement pathway
Synonym: complement pathways
Tree Number: T4.8.30.19
database_cross_reference: CHV:0000057794
database_cross_reference: CSP:1557-8754
database_cross_reference: NCI:C39033
database_cross_reference: NCI_BioC:C39033

CSK Protein Kinase Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Interaction of T cell receptor with specific antigen in the context of MHC II activates a signal transduction pathway that leads to T cell activation. In the T cell receptor signaling pathway, the src family kinases Lck and Fyn are activated to phosphorylate proteins in the T cell receptor complex which recruit and activate the ZAP70 kinase. The activation of ZAP70 phosphorylates downstream targets that activate MAP kinase pathways and cause T cell activation. The CD45 phosphorylase also plays a role in T cell receptor signaling, dephosphorylated Lck and Fyn to activate them. Other factors modulate T cell receptor activation. Csk (COOH-terminal Src kinase) phosphorylates Lck and deactivates it, opposing the action of CD45. The phosphorylation of Lck by Csk inhibits T cell receptor signaling and inhibits T cell activation. Csk activity is regulated in T cells by PKA, the cAMP-dependent protein kinase activated by the second messenger cAMP. The activity of Csk also appears to depend on other factors such as CBP, which recruits Csk to the plasma membrane in lipid rafts where other signaling factors such the T cell receptor complex are localized. CBP also directly activates Csk. (This definition may be outdated - see the DesignNote.)
MCID: MC00523382
PMOID: PMO:00014800
Subclass_of: Immune Response Regulation Pathway
Synonym: Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
Tree Number: T4.8.30.20
database_cross_reference: NCI:C39038
database_cross_reference: NCI_BioC:C39038

CTL-mediated Immune Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Cytotoxic T lymphocytes (CTLs), also known as killer T cells, provide a cell-mediated response to specific foreign antigens associated with cells. CTLs only respond to foreign antigen when it is presented bound to the MHC-1 expressed on the surface of cells. CTLs do not respond to soluble antigen, but induce apoptosis in viral-infected cells and in cancer cells. When the complex of antigen bound to MHC-1 is bound to antigen-specific T cell receptor, the cytotoxic T cell induces apoptosis in the target cell primarily by two pathways, one involving perforin-mediated apoptosis and the other involving Fas/Fas-ligand interaction. When CTLs are activated by recognition of specific antigen on a cell, they release perforin proteins that integrate into the membrane of the target cell and organize to form a membrane pore. This allows the protease granzyme to enter the cell and activate the apoptotic caspase proteolytic cascade, and also allows other molecules to cross the cell membrane and trigger osmotic lysis of the membrane. The interaction of T-cell Fas ligand with the Fas receptor in the target cell can also activate the caspase cascade and other pathways involved in apoptosis. The interaction of a CTL with antigen-MHC I complex activates the CTL to proliferate and amplify the clone of T cells that respond to that antigen, amplifying the immune response against that specific antigen. (This definition may be outdated - see the DesignNote.)
MCID: MC00523384
PMOID: PMO:00014801
Subclass_of: Immune Response Regulation Pathway
Synonym: CTL mediated immune response against target cells
Tree Number: T4.8.30.21
database_cross_reference: NCI:C39042
database_cross_reference: NCI_BioC:C39042

Cytokine Network Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Several different cell types coordinate their efforts as part of the immune system, including B cells, T cells, macrophages, neutrophils, basophils and eosinophils. Each of these cell types has a distinct role in the immune system, and each communicates with other immune cells using secreted factors called cytokines, including interleukins, TNF, and the interferons. Macrophages phagocytose foreign bodies and are antigen-presenting cells, using cytokines to stimulate specific antigen dependent responses by B and T cells and non-specific responses by other cell types. T cells secrete a variety of factors to coordinate and stimulate immune responses to specific antigen, such as the role of helper T cells in B cell activation in response to antigen. The proliferation and activation of eosinophils, neutrophils and basophils respond to cytokines as well. Cytokine communication is often local, within a tissue or between cells in close proximity. Each of the cytokines is secreted by one set of cells and provokes a response in another target set of cells, often including the cell that secretes the cytokine. Some cytokines, like IL-1, interferons and TNF, stimulate a broad inflammatory response in response to infection or injury. Other cytokines have more specific functions such the following examples. IL-2 stimulates the proliferation and activation of B and T cells. IL-4 plays a role in the differentiation of Th2 cells, in allergic responses, and in the switching of antibody types. IL-5 stimulates the production and maturation of eosinophils during inflammation. IL-8 is a chemokine, a chemotactic factor that attracts neutrophils, basophils and T cells to sites of inflammation. IL-12 and IL-18 are involved in helper T cell differentiation. IL-10 apparently acts to repress secretion of proinflammatory cytokines. The complex interplay of these different cytokine functions with immune cells is essential for correct immune function. (This definition may be outdated - see the Des…
MCID: MC00523465
PMOID: PMO:00014802
Subclass_of: Immune Response Regulation Pathway
Synonym: Cytokine Network
Tree Number: T4.8.30.22
database_cross_reference: NCI:C39044
database_cross_reference: NCI_BioC:C39044

Cytotoxic T Cell Surface Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Cytotoxic T cells are a key part of the cellular immune response, killing cells that display foreign antigen on their surface, primarily virus-infected cells. Transformed cells can also be detected and eliminated by cytotoxic T cells. There are two mechanisms by which activated cytotoxic T cells kill cells presenting specific antigen. One method involves the release of secretory granules containing perforin and granzyme to induce lysis of the targeted cell. Cytotoxic T cells also express Fas ligand to bind to Fas on target cells and induce apoptosis. Communication with and interaction with other cell types is essential for cytotoxic T cell function. Distinct types of T cells are characterized and their activities determined by the proteins they express on their cell surface. Cytotoxic T cells will only respond to antigen presented on the surface of cells bound to MHC I proteins, not antigens present in solution. The T cell receptor, with the multiprotein CD3 complex, is responsible for the recognition of specific antigens, triggering the activation and proliferation of cells. Cytotoxic T cell activation also requires additional signals provided by helper T cells in addition to signals provided by antigen-presenting cells. Thy1 provides a general marker of T cells, and the presence of CD8 protein that binds to MHC distinguishes cytotoxic T cells from CD4 positive helper T cells. CD28 expressed by T cells acts as a costimulatory signal with the T cell receptor when it binds its ligand, a B-7 coreceptor, on antigen-presenting cells (see The Co-Stimulatory Signal During T-cell Activation). Inappropriate regulation of the costimulatory signal can lead to too great or too small of an immune response. Interaction of activated cytotoxic T cells is aided by increased expression of LFA-1, a cell-adhesion molecule that binds to ICAM on target cells. CD2 is a T cell adhesion molecule. Mice with a disrupted CD2 gene are largely normal and appear to have a normal immune system, b…
MCID: MC01394154
PMOID: PMO:00014803
Subclass_of: Immune Response Regulation Pathway
Synonym: T Cytotoxic Cell Surface Molecule Pathway
Synonym: T Cytotoxic Cell Surface Molecules
Tree Number: T4.8.30.23
database_cross_reference: NCI:C91305
database_cross_reference: NCI_BioC:C91305

Dendritic Cell Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: While T cells and B cells carry out the actions of antigen-specific immune responses, antigen-presenting cells called dendritic cells are required for this to happen. The name of dendritic cells is based on their shape, with activated dendritic cells displaying long processes on their surface. When immature dendritic cells found throughout the body internalize and present antigen, they express markers that stimulate the activation of lymphocytes, and migrate to lymphocyte rich tissues like the spleen and lymph nodes to initiate immune responses. In addition to stimulating responses against antigens, dendritic cells also produce tolerance to self antigens. Dendritic cells can be derived from either myeloid or lymphoid lineages. Monocyte (myeloid) derived lineages (pDC1) stimulate Th1 cell differentiation while plasmacytoid (lymphoid) dendritic cells (pDC2) induce Th2 cell differentiation. Factors that stimulate the maturation of monocytes derived dendritic cells include GM-CSF, and IL-4. IL-3 stimulates the differentiation of pDC2 cells into DC2 cells. A variety of factors are involved in antigen-recognition and processing by immature dendritic cells and in the maturation of these cells. The transition to mature dendritic cells down-regulates the factors involved in antigen internalization, and increases the expression of MHC, costimulatory molecules involved in lymphocyte activation, adhesion molecules, and specific cytokines and chemokines. Toll-like receptors on the surface of immature dendritic cells recognize microbial components to induce dendritic cell maturation. In addition to stimulating B cell responses, dendritic cells are potent activators of T cells. IL-12 secretion by dendritic cells stimulates T cell responses, particularly differentiation of Th1 cells that produce interferon-gamma and other pro-inflammatory cytokines. While IL-4 generally stimulates Th2 differentiation, the stimulation of Th2 cell formation by DC2 cells does not appear to involve IL-…
MCID: MC00523558
PMOID: PMO:00014804
Subclass_of: Immune Response Regulation Pathway
Synonym: Dendritic cells in regulating TH1 and TH2 Development
Tree Number: T4.8.30.24
database_cross_reference: NCI:C39048
database_cross_reference: NCI_BioC:C39048

dsRNA Induction Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: One defense against viral infection is provided by PKR, double-stranded RNA activated protein kinase. When PKR interacts with dsRNA found in cells during viral infection, PKR phosphorylates itself and cellular proteins including the translation factor elF2a and the transcription factor NF-kB. The repression of translation caused by phosphorylation of elF2a prevents cells from producing viral proteins and creating infectious viral particles. PKR phosphorylation of I-kB kinase activates NF-kB to induce transcription of inflammatory factors and stimulate an immune response that impedes viral infection. The PKR kinase is induced by interferon and some of the anti-viral activity of interferon may be mediated by PKR. Some viruses have evolved mechanisms to inactivate PKR to promote successful infection. Another substrate of PKR, the tumor suppressor p53, may be involved in potential PKR regulation of the cell cycle and apoptosis. (This definition may be outdated - see the DesignNote.)
MCID: MC00525684
PMOID: PMO:00014805
Subclass_of: Immune Response Regulation Pathway
Synonym: Double Stranded RNA Induced Gene Expression
Tree Number: T4.8.30.25
database_cross_reference: NCI:C39224
database_cross_reference: NCI_BioC:C39224

Fc Epsilon Receptor I Signaling Pathway BioCarta
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The Fc Epsilon Receptor 1 signaling pathway in mast cells uses multiple core signal paths to achieve its necessary ends. Through the BTK protein and PKC Mast cells are able to degranulate, through the PKC and MAPK paths the cells are able to alter cytokine expression and arachidonic acid release. (This definition may be outdated - see the DesignNote.)
MCID: MC00526466
PMOID: PMO:00014806
Subclass_of: Immune Response Regulation Pathway
Synonym: Fc Epsilon Receptor I Signaling in Mast Cells
Tree Number: T4.8.30.26
database_cross_reference: NCI:C39079
database_cross_reference: NCI_BioC:C39079

Fc Epsilon Receptor I Signaling Pathway KEGG
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
MCID: MC01394347
PMOID: PMO:00014807
Subclass_of: Immune Response Regulation Pathway
Synonym: Fc epsilon RI signaling pathway
Tree Number: T4.8.30.27
database_cross_reference: NCI:C91476
database_cross_reference: NCI_KEGG:C91476

Fc-Epsilon Receptor I Signaling Pathway PID
type: Class
subclass of: Immune Response Regulation Pathway
MCID: MC01394305
PMOID: PMO:00014808
Subclass_of: Immune Response Regulation Pathway
Synonym: Fc-epsilon receptor I signaling in mast cells
Tree Number: T4.8.30.28
database_cross_reference: NCI:C91595
database_cross_reference: NCI_PID:C91595

Hematopoietic Cell Lineage Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing this differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
MCID: MC01394325
PMOID: PMO:00014809
Subclass_of: Immune Response Regulation Pathway
Synonym: Hematopoietic cell lineage
Tree Number: T4.8.30.29
database_cross_reference: NCI:C91459
database_cross_reference: NCI_KEGG:C91459

IL10 Anti-inflammatory Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by activated macrophages. The IL-10 receptor is in the JAK/STAT class of receptors but activation of the JAK/STAT pathways by IL-10 does not appear on its own to be responsible for the anti-inflammatory properties of this cytokine. The anti-inflammatory actions of IL-10 appear to require induction of the enzyme heme oxygenase-1 (HO-1) through a map kinase pathway involving the p38 kinases. HO-1 is involved in the biosynthesis of heme, and catalyzes a reaction producing carbon monoxide, free iron, and the heme precursor biliverdin. HO-1 is induced by IL-10 and is also induced by oxidative stress. Blocking HO-1 with inhibitors or antisense blocks the anti-inflammatory actions of IL-10. The anti-inflammatory actions of HO-1 appear to be the result of signaling by the carbon monoxide it produces since removal of CO blocks the anti-inflammatory action of IL-10 and HO-1. The anti-inflammatory actions of IL-10 may be therapeutically useful either directly or through modulation of HO-1 activity. (This definition may be outdated - see the DesignNote.)
MCID: MC00523999
PMOID: PMO:00014810
Subclass_of: Immune Response Regulation Pathway
Synonym: IL-10 Anti-inflammatory Signaling Pathway
Tree Number: T4.8.30.30
database_cross_reference: NCI:C39116
database_cross_reference: NCI_BioC:C39116

IL2RB Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells. This receptor is composed of three polypeptide chains, the alpha, beta, and gamma chains. The IL-2 receptor gamma chain is a common component for several other cytokine receptors, including IL-4, IL-7, IL-9 and IL-15. The IL-2 receptor beta chain is essential for IL-2 signaling and is also a component of the IL-15 receptor complex. The polypeptides of the IL-2 receptor do not themselves have intrinsic catalytic activity, but interact with cytoplasmic signaling proteins to transduce signals. Different regions of the cytoplasmic domain of the IL-2 receptor beta chain interact and couple with distinct signaling pathways and cellular responses. JAK1 associates with the beta chain and JAK3 with the gamma chain. Binding of IL-2 induces heterodimerization of receptor subunits, and activation of JAK kinase activity. Tyrosine residues in the beta chain cytoplasmic domain are phosphorylated during activation, recruiting other factors to the phosphorylated tyrosine residues through src homology 2 (SH2) domains. The adaptor protein Shc binds to phosphorylated tyrosine 338 of the beta chain. When bound, Shc is phosphorylated and couples through Grb2 and Sos-1 to activate Ras and stimulate T cell proliferation. Another key proliferative pathway activated by IL-2 is phosphorylation of STAT-5 by JAK kinases. STAT-5 is recruited to IL-2 beta phosphorylated tyrosines at multiple positions, including Y338, Y392 and Y510. Once phosphorylated, STAT-5 enters the nucleus to regulate the transcription of several genes, some proliferative, such as cyclin genes, and others that are involved in T cell immune function such as cytokine genes. The suppressors of cytokine activation, SOCS-3 and SOCS-1, oppose phosphorylation and activation of STAT-5 and JAK1 caused by IL-2. PI3 kinase is another protein recruited to IL-2 receptor beta chain tyrosines when phosphoryl…
MCID: MC00524005
PMOID: PMO:00014811
Subclass_of: Immune Response Regulation Pathway
Synonym: IL-2 Receptor Beta Chain in T cell Activation
Tree Number: T4.8.30.31
database_cross_reference: NCI:C39123
database_cross_reference: NCI_BioC:C39123

Inflammatory Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead to destruction of tissues in autoimmune disorders and perhaps neurodegenerative or cardiovascular disease. Secreted cytokine proteins provide signals between immune cells to coordinate the inflammatory response. Some cytokines such as IL-1, IL-6, and TNF act to broadly provoke the inflammatory response while others act on specific types of immune cells. Macrophages and other phagocytotic cells provide a front-line defense against bacterial infection. Macrophages stimulate the inflammatory responses of neutrophils, fibroblasts, and endothelial cells in response to infection by secreting IL-1 and TNF. IL-1 and TNF cause fever through alteration of the body temperature set-point in the hypothalamus. Fibroblasts and endothelial cells respond to IL-1 and TNF by recruiting more immune cells to the site of inflammation. Secreted IL-8 is a chemokine that attracts neutrophils to sites of infection. Macrophages also present antigen to T helper cells that play a central role in coordinating immune responses. T helper cells induce clonal expansion of T cells that respond to antigen, with IL-2 as a key mediator of T cell proliferation and activation. TGF-beta is a negative regulator of proliferation in many cells, having anti-inflammatory actions in some settings. The cytotoxic activity of Natural Killer cells (NK cells) and lymphokine activated killer cells (LAK cells) toward viral infected or tumor cells is stimulated by IL-2 and other cytokines. T helpers secrete IL-3 and IL-5 to stimulate eosinophil proliferation and activation. Eosinophils are involved in the immune response to parasitic infection. T helper cells are required to stimulate B cell responses as well, with the cytokines IL-10, IL-4 a…
MCID: MC00524096
PMOID: PMO:00014812
Subclass_of: Immune Response Regulation Pathway
Synonym: Cytokines and Inflammatory Response
Tree Number: T4.8.30.32
database_cross_reference: NCI:C39129
database_cross_reference: NCI_BioC:C39129

Intestinal IgA Production Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-committed plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-beta, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
MCID: MC01393855
PMOID: PMO:00014813
Subclass_of: Immune Response Regulation Pathway
Synonym: Intestinal immune network for IgA production
Synonym: Pathway for IgA Production
Tree Number: T4.8.30.33
database_cross_reference: NCI:C91518
database_cross_reference: NCI_KEGG:C91518

Lectin Induced Complement Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The complement cascade of proteolytic factors involved in cellular lysis can be initiated by several different factors, including antibody-dependent and antibody-independent recognition of infectious organisms. In the lectin-induced complement cascade, carbohydrates on the surface of microbial cells activate the complement cascade by binding to mannan-binding lectin (also called the mannan-binding protein, Mbl/Mbp). Mbp is an acute phase serum protein whose expression is induced by microbial infection. The binding of Mbl to microbial ligands activates the Mbl associated serine proteases Masp1 and Masp2, triggering the cleavage of C2 and C4 to create C4bC2a, a C3 convertase that cleaves large numbers of C3. Masp1 and Masp2 are similar to the C1 protease in the classical complement pathway. Once formed the C3 convertase cleaves and activates the remaining complement factors leading ultimately to formation of a pore in the bacterial membrane by the membrane attack complex (MAC) that lyses the bacterial cell. The lectin-induced pathway also appears to play an important role of the activation of phagocytotic cells by infection. Although the initiating event activating the complement cascade is distinct in the lectin-induced pathway, from the C3 convertase onward the lectin induced complement pathway is the same as the classical complement pathway. Since antibodies are not required in the lectin-induced pathway, this aspect of the immune response is part of the innate immune response. The importance of this pathway to the immune response has been demonstrated by the identification of children and adults with little or no Mbl who lacked normal phagocytotic responses and are highly susceptible to infection. (This definition may be outdated - see the DesignNote.)
MCID: MC00526795
PMOID: PMO:00014814
Subclass_of: Immune Response Regulation Pathway
Tree Number: T4.8.30.34
database_cross_reference: NCI:C39138
database_cross_reference: NCI_BioC:C39138

Leukocyte Transendothelial Migration Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Leukocyte migration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL/beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metalloproteinases and loss of VE-cadherin-mediated adhesion.
MCID: MC01394093
PMOID: PMO:00014815
Subclass_of: Immune Response Regulation Pathway
Synonym: Leukocyte transendothelial migration
Tree Number: T4.8.30.35
database_cross_reference: NCI:C91439
database_cross_reference: NCI_KEGG:C91439

Local Acute Inflammatory Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Inflammation has several distinct components, including the localized response at the site of tissue injury or infection. Tissue injury stimulates the release of inflammatory signaling molecules such as bradykinin. Bacterial infection stimulates an immune response in several ways. Bacteria that are phagocytosed can activate macrophages, causing the release of inflammatory cytokines such as IL-1, TNF, and IL-6. Bacteria can also activate the complement cascade through either the antibody-mediated pathway (classical pathway) or the alternative complement pathway. In extravascular tissues, cells that respond to infection or injury include macrophages and mast cells. Macrophages and other immune cells secrete chemokines that recruit leukocytes from the circulation to the site of inflammation. Mast cells release histamine, prostaglandins, and leukotrienes that act as chemokines, increase vascular permeability, and act on the vascular endothelium to increase tissue recruitment of leukocytes. Chemokines can recruit leukocytes or lymphocytes out of the blood stream into tissues and make blood vessels more permeable. Leukocytes are activated by inflammatory signals to express adhesion molecules that cause them to interact with the vascular endothelium, penetrate the endothelial wall and migrate into the extracellular space of tissues. The combined response of immune cells and signaling molecules at the site of inflammation induces swelling, activation of immune cells, and clearance of potential infectious agents. Chronic inflammation can however also lead to tissue damage in conditions such as arthritis, in which anti-inflammatory drugs act on various steps in inflammation to prevent disease. (This definition may be outdated - see the DesignNote.)
MCID: MC00526911
PMOID: PMO:00014816
Subclass_of: Immune Response Regulation Pathway
Synonym: local acute inflammatory response
Tree Number: T4.8.30.36
database_cross_reference: NCI:C39136
database_cross_reference: NCI_BioC:C39136

Monocyte Phagocytosis and Adhesion Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Monocytes are a class of phagocytes involved in non-specific immune defense that develop into macrophages. In plasma, monocytes ingest and destroy bacteria, and can form macrophages when they enter the extracellular space in tissues. In addition to the immune protection that monocytes provide, they may contribute to disease states such as arthritis and heart disease through an aberrant immune response. As with other immune cells, the immune function and differentiation of monocytes rely on communication with other cells through cell surface proteins. Cell surface proteins are involved in both interaction and adhesion with other cells and in transducing signals into the cellular interior. The LFA-1 integrin (Leukocyte function-associated molecule 1) is composed of two subunits, CD11a and CD18 and is involved in monocytes adhesion with ICAM-1 endothelial cells. Mac-1 is composed of the subunits CD11b and CD18 and is induced during inflammation as well. PECAM-1 mediates the migration of monocytes and other immune cells into inflamed tissues through interaction with vascular endothelial cells. CD44 interaction of leukocytes with hyaluronan in the extracellular matrix is induced by inflammation. VLA-4 is another integrin expressed on lymphocytes that plays a role in adhesion through interaction with its adhesion partner on endothelial cells, VCAM-1. (This definition may be outdated - see the DesignNote.)
MCID: MC01394160
PMOID: PMO:00014817
Subclass_of: Immune Response Regulation Pathway
Synonym: Monocyte and its Surface Molecules
Tree Number: T4.8.30.37
database_cross_reference: NCI:C91307
database_cross_reference: NCI_BioC:C91307

Natural Killer Cell-Mediated Cytotoxicity Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stress, such as infection with viruses, bacteria, or parasites or malignant transformation. Although NK cells do not express classical antigen receptors of the immunoglobulin gene family, such as the antibodies produced by B cells or the T cell receptor expressed by T cells, they are equipped with various receptors whose engagement allows them to discriminate between target and nontarget cells. Activating receptors bind ligands on the target cell surface and trigger NK cell activation and target cell lysis. However Inhibitory receptors recognize MHC class I molecules (HLA) and inhibit killing by NK cells by overruling the actions of the activating receptors. This inhibitory signal is lost when the target cells do not express MHC class I and perhaps also in cells infected with virus, which might inhibit MHC class I expression or alter its conformation. The mechanism of NK cell killing is the same as that used by the cytotoxic T cells generated in an adaptive immune response; cytotoxic granules are released onto the surface of the bound target cell, and the effector proteins they contain penetrate the cell membrane and induce programmed cell death.
MCID: MC01394102
PMOID: PMO:00014818
Subclass_of: Immune Response Regulation Pathway
Synonym: NK Cell Cytotoxicity
Synonym: Natural killer cell mediated cytotoxicity
Tree Number: T4.8.30.38
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91442
database_cross_reference: NCI_KEGG:C91442

Neutrophil Surface Molecule Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Neutrophils are important phagocytotic leukocytes (white blood cells) that internalize and destroy infectious bacteria by a respiratory burst of reactive oxygen species and by enzymatic digestion. Along with macrophages, neutrophils are crucial phagocytotic cells of the immune system and also contribute to anti-viral defenses, binding to and eliminating free virus or virus-infected cells. The presence of cytoplasmic granules in neutrophils leads to their classification as granulocytes, along with basophils and eosinophils. A lack of neutrophils or their normal function causes a variety of immune disorders and measuring neutrophil cell surface proteins can diagnose abnormal immune function. One such disorder is caused by a lack of normal expression of the adhesion molecules CD11 and CD18 by neutrophils, preventing them from interacting normally with adhesion molecules on endothelial cells and migrating into inflamed sites in tissues. CD11a and CD18 together form the LFA-1 receptor for ICAM-1 on endothelial cells and CD11b/CD18 form Mac-1. Deletion of the CD18 gene in mice produces a significant reduction in leukocyte emigration to sites of inflammation. CD44 is involved in the interaction of neutrophils with endothelial cells and the extracellular matrix during inflammation. The binding of selectins with their carbohydrate ligands also regulates adhesion of neutrophils with endothelial cells, with P- and L-selectins moderating initial interactions and E-selectin moderating subsequent interactions. Genetic disruption of the ability of neutrophils to kill internalized bacteria also impairs normal immune function, along with genetic or acquired lack of the normal number of neutrophils (neutropenia). CD11b binding to a complement component and CD16 binding to IgG Fc contribute to phagocytosis. Inflammatory cytokines activate neutrophils and chemotactic peptides attract them to sites of infection. Inflammatory molecules that activate neutrophils include IL-1, TNF, IL-6, C…
MCID: MC01394291
PMOID: PMO:00014819
Subclass_of: Immune Response Regulation Pathway
Synonym: Neutrophil and Its Surface Molecules
Tree Number: T4.8.30.39
database_cross_reference: NCI:C91311
database_cross_reference: NCI_BioC:C91311

NO2-Dependent IL12 Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Macrophages and NK cells help provide innate immunity against infection by intracellular parasites and communicate with each other to regulate this process. When stimulated, macrophages secrete the cytokine IL-12 which is essential for activation of the cytotoxic activity of natural killer (NK) cells. IL-12 stimulates this NK cell response through activation of a JAK/STAT signaling pathway. Binding of IL-12 to its receptor on NK cells causes tyrosine phosphorylation and activation of JAK2 and another JAK kinase, Tyk2. Tyk2 in turn phosphorylates the transcription factor STAT4, which can then translocate to the nucleus to activate genes, including the expression of interferon-gamma. IFN-gamma and IL-12 induce the differentiation of TH1 helper T cells that activate macrophages through interferon-gamma. A key modulator of NK cell activation by IL-12 is nitric oxide, NO, produced from arginine by the inducible nitric oxide synthase NOS2. Inactivation of the NOS2 gene in mice impairs the initial innate response to infection, including the activation of NK cells. This phenotype is similar to that of mice lacking interferon-gamma or IL-12 and a similar effect can be produced by inhibiting NOS2 with L-N6-iminoethyl-lysine (L-NIL) during infection, blocking the activation of NK cells by IL-12. NO production does not affect the activation of JAK2 by IL-12, but is required for Tyk2 activity, the downstream activation of STAT-4 and the production of interferon-gamma by NK cells. The role of NO in Tyk2 activation is not yet known, but does not seem to involve changing the phosphorylation status of Tyk2. Curiously, activation of T cells by IL-12 does not appear to involve NO production, indicating a distinct mechanism is involved in NK cells. NO also plays a role as a feedback inhibitor of IL-12 production by macrophages, helping to prevent over-activation of the Th1 cells by IL-12. NO appears to make an important contribution to the early innate response to infections before spe…
MCID: MC00524577
PMOID: PMO:00014820
Subclass_of: Immune Response Regulation Pathway
Synonym: NO2-dependent IL 12 Pathway in NK cells
Tree Number: T4.8.30.40
database_cross_reference: NCI:C39168
database_cross_reference: NCI_BioC:C39168

Ras-Independent Cell-Mediated Cytotoxicity Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK cell-mediated cytotoxicity is activated by glycoproteins on the cell surface (activating receptors) and inhibited by MHC-1 with self-peptide bound. The MHC-1 inhibitory signal through Ig-family or lectin receptors prevents NK cells from killing normal cells. Abnormal MHC-1 expression in infected or tumor cells results in the release of perforin, the lysis of the abnormal cell and the release of cytokines that stimulate the immune response. MAP kinase inhibitors, but not ras inhibitors, are able to block NK cell cytotoxicity, indicating that the pathway can function by a ras-independent manner that involves the MAP kinase pathway. This pathway includes phosphoinositide-3-kinase (PI3K) as a key component, followed by Rac1 and the exchange factor Vav. The tyrosine kinase SYK and LAT may provide an additional pathway for activation of MAP kinases leading to NK cell activation, and also Pyk-2 activation by integrins. The protein tyrosine phosphatase SHP-1 appears to mediate the cytotoxicity inhibitory signal that blocks lysis of normal cells. The balance of these positive and negative signaling pathways regulates the role of NK cells in the immune response. (This definition may be outdated - see the DesignNote.)
MCID: MC00525106
PMOID: PMO:00014821
Subclass_of: Immune Response Regulation Pathway
Synonym: Ras-Independent pathway in NK cell-mediated cytotoxicity
Tree Number: T4.8.30.41
database_cross_reference: NCI:C39165
database_cross_reference: NCI_BioC:C39165

T Cell Receptor and CD3 Complex Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The T cell receptor is a cell-surface receptor that recognizes specific antigen to stimulate the T cell response to that antigen. The T cell receptor complex of transmembrane proteins includes the T cell receptor that recognizes antigen and a set of proteins called CD3 involved in signal transduction. CD3 associated with the T cell receptor includes six polypeptides arranged in three dimers that recruit and activate protein kinases to signal the activation of T cell receptor by bound antigen through recruitment and activation of protein kinases (see T Cell Receptor Signaling Pathway). T cell receptors only recognize antigen on the surface of other cells, not antigen in solution, by requiring antigen to be bound to MHC proteins on the surface of other cells to be recognized. Cytotoxic T cells recognize antigen bound to MHC I on the surface of other cells and helper T cells recognize antigen bound to MHC II on antigen-presenting cells. CD4 (helper T cells) and CD8 (cytotoxic T cells) are cofactors in MHC recognition. Recombination in immature T cells of the genes for the alpha and beta T cell receptor subunits creates a huge variety of variable regions involved in antigen recognition resulting in many antigen specificities in the population of immature T cells. Some T cells called gamma/delta cells express T cell receptor composed of gamma and delta subunits rather than alpha/beta subunits. When the T cell receptor on a cell interacts with antigen in the proper context, that cell is stimulated to become activated and proliferate, in a process known as clonal selection. The recombination of T cell receptor genes and clonal selection of cells that bind specific antigen is very similar to the B cell process that creates immunoglobulins and clonal selection of B cells that bind antigen. (This definition may be outdated - see the DesignNote.)
MCID: MC01394150
PMOID: PMO:00014822
Subclass_of: Immune Response Regulation Pathway
Synonym: T Cell Receptor and CD3 Complex
Synonym: T Cell Receptor and CD3 Complex Pathway
Tree Number: T4.8.30.42
database_cross_reference: NCI:C91304
database_cross_reference: NCI_BioC:C91304

T Cell Receptor Signaling Pathway BioCarta
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell's transcriptional machinery upon engagement of the receptor. (This definition may be outdated - see the DesignNote.)
MCID: MC00451128
PMOID: PMO:00014823
Subclass_of: Immune Response Regulation Pathway
Synonym: T Cell Receptor Signaling Pathway
Synonym: T cell receptor signaling pathway
Synonym: T lymphocyte receptor signaling pathway
Synonym: T lymphocyte receptor signalling pathway
Synonym: T-cell receptor signaling pathway
Synonym: T-cell receptor signalling pathway
Synonym: T-lymphocyte receptor signaling pathway
Synonym: T-lymphocyte receptor signalling pathway
Synonym: TCR signaling pathway
Tree Number: T4.8.30.43
database_cross_reference: GO:GO:0050852
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39246
database_cross_reference: NCI_BioC:C39246

T Cell Receptor Signaling Pathway KEGG
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.
MCID: MC01394140
PMOID: PMO:00014824
Subclass_of: Immune Response Regulation Pathway
Synonym: T cell receptor signaling pathway
Synonym: TCR Signaling Pathway
Tree Number: T4.8.30.44
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91450
database_cross_reference: NCI_KEGG:C91450

T Helper Cell Surface Molecule Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: T helper cells play an essential role coordinating the activities of other parts of the immune system, including B cells, cytotoxic T cells, macrophages and other cells. The crucial nature of helper T cells in the normal immune response is demonstrated by the severe immune deficiency associated with the HIV-induced helper T cell depletion. To communicate with other cells, helper T cells express a range of cell surface molecules, a few of which are illustrated in this figure. Like all T cells, helper T cells express T cell receptors complexed with the CD3 proteins that are responsible for the recognition and response of the cell to specific antigens (see T Cell Receptor Signaling Pathway). CD4 is commonly used as a marker for helper T cells, in contrast to cytotoxic T cells, which express CD8. CD4 is used by HIV to gain cell entry, as well as the CCR5 chemokine receptor. Thy1 provides a more general cell surface antigen used to identify both T helper and cytotoxic T cells. CD28 provides a costimulatory signal in association with the activation of the T cell receptor complex by an antigen presenting cell that is required for the T cell to become activated (see The Co-Stimulatory Signal During T-cell Activation pathway). Adhesion molecules on the surface of T cells assist in their interaction with other cells. LFA-1 binds to its ligand ICAM-1 in a variety of cells and T cells themselves also express ICAM-1. The CD45 protein tyrosine phosphatase dephosphorylates factors in the pathways involved in B cells and T cells activation. Although CD45 is required for T cell receptor activation, exclusion of CD45 from the local membrane region near the T cell receptor appears important for efficient T cell activation. Helper T cells can be subdivided further into Th1 and Th2 cells, distinguished by their response to different antigens, differing cytokine expression and expression of different chemokine receptors (see Selective expression of chemokine receptors during T-cell polar…
MCID: MC01394158
PMOID: PMO:00014825
Subclass_of: Immune Response Regulation Pathway
Synonym: T Helper Cell Surface Molecules
Tree Number: T4.8.30.45
database_cross_reference: NCI:C91306
database_cross_reference: NCI_BioC:C91306

T-Cell Activation Co-Stimulatory Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: For a T cell to be activated by a specific antigen, the T cell receptor must recognize complexes of MHC-1 with the antigen on the surface of an antigen-presenting cell. T cells and the T cell receptor complex do not respond to antigen in solution, but even for the specific antigen they only respond to antigen-MHC-1 complexes on the cell surface. This interaction is necessary for T cell activation, but it is not sufficient. T cell activation also requires a co-stimulatory signal involving interaction of CD28 on the T cell with CD80 or CD86 (B7 family genes) on the antigen-presenting cell. CD28 activates a signal transduction pathway acting through PI-3K, Lck and Grb-2/ITK to provide its co-stimulatory signal for T cell activation. Another means to control T cell activation is by expressing factors that down-regulate T cell activation. Signaling by activated T cell receptors induces expression of CTLA-4, a receptor that opposes T cell activation. CTLA-4 has a higher affinity than CD28 for B7 proteins, terminating T cell activation. ICOS is a protein related to CD28 that is only expressed on activated T cells, and that provides another important co-stimulatory signal. The requirement for co-stimulatory signals provides additional control mechanisms that prevent inappropriate and hazardous T cell activation. (This definition may be outdated - see the DesignNote.)
MCID: MC00525303
PMOID: PMO:00014826
Subclass_of: Immune Response Regulation Pathway
Synonym: The Co-Stimulatory Signal During T-cell Activation
Tree Number: T4.8.30.46
database_cross_reference: NCI:C39041
database_cross_reference: NCI_BioC:C39041

T-Cell Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Regulation of T cell activation is a crucial component of balanced functioning of the immune system. If the T cell response is too great and activation of self-responsive cells or unstimulated cells is not suppressed, then autoimmune disorders or tissue injury can result. Unstimulated T cells are maintained in a quiescent state and the activity of self-reactive T cells is maintained in an anergic state in which IL-2 expression is repressed. IL-2 is a cytokine with a key role in the activation and proliferation of T cells. The maintenance of T cells in the anergic or unstimulated state may not involve just an absence of activation, but an active repression of IL-2 expression, T cell proliferation, and activation. TGF beta may play a role in suppressing T cell activation. Tob is a member of a family of genes with anti-proliferative properties that represses T cell activation. Tob expression is highest in unstimulated and anergic T cells, and is reduced in activated T cells. Tob interacts with the TGF activated transcription factors SMAD2 and SMAD4, increasing their binding to the IL-2 promoter, and helping to repress IL-2 expression. This role of Tob suggests that interference in Tob's function may lead to autoimmune disease. (This definition may be outdated - see the DesignNote.)
MCID: MC00525304
PMOID: PMO:00014827
Subclass_of: Immune Response Regulation Pathway
Synonym: Role of Tob in T-cell activation
Tree Number: T4.8.30.47
database_cross_reference: NCI:C39256
database_cross_reference: NCI_BioC:C39256

T-Cell Antiapoptosis Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB. (This definition may be outdated - see the DesignNote.)
MCID: MC00525305
PMOID: PMO:00014828
Subclass_of: Immune Response Regulation Pathway
Synonym: Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
Tree Number: T4.8.30.48
database_cross_reference: NCI:C39266
database_cross_reference: NCI_BioC:C39266

T-Cell Polarization Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: Chemokine receptors expressed by T helper cells help recruit cells to specific locations based on their chemoattractant ligands. The polarization of T cells into Th1 and Th2 cells is associated with their expression of different subsets of chemokine receptors. Naive CD4 positive cells that have not been exposed to antigen express CXCR4 and CCR7. The most abundant chemokine receptors on Th1 cells involved in the cellular immune response to microbial agents include CXCR3, CCR1, CCR2 and CCR5, while Th2 cells express CCR2, CCR3 and CCR5. An additional class of T cells termed semi-naive cells may be induced by TGF-beta to express yet another class of chemokine receptors, CCR4 and CCR7. Although the expression of chemokine receptors in different cells is preferred in these cases, it is not absolute or exclusive, and there is overlap in expression between Th1 and Th2 cells. Although CCR7 positive cells have been reported to lack effector action, not be polarized, and to home only to lymphoid tissues, other studies have found CCR7 positive Th1 and Th2 cells and have identified CCR7 positive cells in non-lymphoid tissues. CCR4 appears associated with homing of lymphocytes to the skin, and CCR9 is associated with homing to the small intestine, while other chemokines like CXCR3 and CCR5 are associated with homing toward inflamed tissues more broadly. The expression of different chemokine receptors by subsets of T helper cells plays an important role in the migration and homing of these cells in tissues, and targeting of the immune response to specific cells. (This definition may be outdated - see the DesignNote.)
MCID: MC01393919
PMOID: PMO:00014829
Subclass_of: Immune Response Regulation Pathway
Synonym: Selective expression of chemokine receptors during T-cell polarization
Tree Number: T4.8.30.49
database_cross_reference: NCI:C39166
database_cross_reference: NCI_BioC:C39166

T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
type: Class
subclass of: Immune Response Regulation Pathway
MCID: MC01394203
PMOID: PMO:00014830
Subclass_of: Immune Response Regulation Pathway
Synonym: TCR signaling in naïve CD4+ T cells
Tree Number: T4.8.30.50
database_cross_reference: NCI:C91553
database_cross_reference: NCI_PID:C91553

Calcium Signaling in the CD4+ TCR Pathway
type: Class
subclass of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
MCID: MC01394220
PMOID: PMO:00014831
Subclass_of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
Synonym: Calcium signaling in the CD4+ TCR pathway
Tree Number: T4.8.30.50.1
database_cross_reference: NCI:C91557
database_cross_reference: NCI_PID:C91557

JNK Signaling in the CD4+ TCR Pathway
type: Class
subclass of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
MCID: MC01393836
PMOID: PMO:00014832
Subclass_of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
Synonym: JNK signaling in the CD4+ TCR pathway
Tree Number: T4.8.30.50.2
database_cross_reference: NCI:C91629
database_cross_reference: NCI_PID:C91629

Ras Signaling in the CD4+ TCR Pathway
type: Class
subclass of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
MCID: MC01393747
PMOID: PMO:00014833
Subclass_of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
Synonym: Ras signaling in the CD4+ TCR pathway
Tree Number: T4.8.30.50.3
database_cross_reference: NCI:C91657
database_cross_reference: NCI_PID:C91657

T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells
type: Class
subclass of: Immune Response Regulation Pathway
MCID: MC01394172
PMOID: PMO:00014834
Subclass_of: Immune Response Regulation Pathway
Synonym: TCR signaling in naïve CD8+ T cells
Tree Number: T4.8.30.51
database_cross_reference: NCI:C91554
database_cross_reference: NCI_PID:C91554

Downstream Signaling Pathway in Naive CD8+ T Cells
type: Class
subclass of: T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells
MCID: MC01394101
PMOID: PMO:00014835
Subclass_of: T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells
Synonym: Downstream signaling in naïve CD8+ T cells
Tree Number: T4.8.30.51.1
database_cross_reference: NCI:C91573
database_cross_reference: NCI_PID:C91573

TCR Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: T cell activation is initiated by recognition of antigen by the T cell receptor (TCR) in the context of Class II MHC on an antigen-presenting cell. The T cell receptor contains multiple subunits and interacts with several factors to transduce antigen-stimulated T cell activation. One of the key steps that initiates receptor activation is the tyrosine phosphorylation of TCR subunits by the src family protein kinases Lck and Fyn. T cell receptor phosphorylated by Lck and Fyn recruits the ZAP-70 protein kinase to the receptor complex, which becomes activated and stimulates downstream pathways like the Map kinase cascade. The CD45 protein tyrosine phosphatase activates Lck and Fyn by dephosphorylating these proteins and is required for TCR activation. Association of the CD4 coreceptor with Lck may also be involved in Lck activation. (This definition may be outdated - see the DesignNote.)
MCID: MC00525325
PMOID: PMO:00014836
Subclass_of: Immune Response Regulation Pathway
Synonym: Lck and Fyn tyrosine kinases in initiation of TCR Activation
Tree Number: T4.8.30.52
database_cross_reference: NCI:C39245
database_cross_reference: NCI_BioC:C39245

Toll-Like Receptor Pathway
type: Class
subclass of: Immune Response Regulation Pathway
Definition: The innate immune response responds in a general manner to factors present in invading pathogens. Bacterial factors such as lipopolysaccharides (LPS, endotoxin), bacterial lipoproteins, peptidoglycans, and also CpG nucleic acids activate innate immunity as well as stimulating the antigen-specific immune response and triggering the inflammatory response. Members of the toll-like receptor (TLR) gene family convey signals stimulated by these factors, activating signal transduction pathways that result in transcriptional regulation and stimulate immune function. TLR2 is activated by bacterial lipoproteins, TLR4 is activated by LPS, and TLR9 is activated by CpG DNA; peptidoglycan recognition protein (PGRP) is activated by peptidoglycan (PGN). The downstream signaling pathways used by these receptors are similar to that used by the IL-1 receptor, activating the IL-1 receptor associated kinase (IRAK) through the MyD88 adaptor protein, and signaling through TRAF-6 and protein kinase cascades to activate NF-kB and Jun. NF-kB and c-Jun activate transcription of genes such as the proinflammatory cytokines IL-1 and IL-12. Several reports have suggested that the functional outcomes of signaling via TLR2, TLR4, and PGRP are not equivalent. For example, while the LPS-induced, p38-dependent response was dependent upon PU.1 binding, the PGN-induced, p38 response was not. The intracellular receptor for PGN, PGRP, is conserved from insects to mammals. In insects, PGRP activates prophenoloxidase cascade, a part of the insect antimicrobial defense system. Because mammals do not have the prophenoloxidase cascade, its function in mammals is unknown. However, it was suggested that an identical protein Tag7 was a tumor necrosis factor-like (TNF-like) cytokine. PGRP/Tag7 possesses cytotoxicity and triggers intranucleosomal DNA fragmentation in target cells in the same way as many known members of the TNF family. Fragmentation of DNA is one of the characteristics of apoptosis. The possibility…
MCID: MC00527686
PMOID: PMO:00014837
Subclass_of: Immune Response Regulation Pathway
Tree Number: T4.8.30.53
database_cross_reference: NCI:C39257
database_cross_reference: NCI_BioC:C39257

Inhibition of Matrix Metalloproteinases Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Cellular transformation is accompanied by many cellular changes, including uncontrolled proliferation, loss of the differentiated cell morphology, and invasion of the extracellular matrix. Degradation of the extracellular matrix is a key component of tumor cell invasion into surrounding tissues. Matrix metalloproteinases (MMPs) are a class of proteases secreted by tumor cells, degrading the proteins of the extracellular matrix and allowing metastasis. Drug inhibitors of MMPs are one strategy to control cancer and block metastasis. In searching for genes that reverse the rounded morphology of transformed cells in culture, RECK was identified (reversion-inducing, cysteine-rich protein with Kazal motifs). RECK is a membrane-anchored inhibitor of matrix metalloproteinases, inhibiting MMP-2, MMP-9, and MT1-MMP. The processing of MMPs to their active form occurs at the plasma membrane, making the localization of RECK at the membrane a key to its potent activity as an inhibitor of MMP activity. Soluble secreted MMP inhibitors have also been identified, TIMPs, which appear to be less active at inhibiting MMPs and even perhaps to be essential for MMP maturation. The inhibition of MMPs by RECK inhibits invasion of tissues, metastasis, and tumor angiogenesis, and is essential for normal development. In addition to playing a role in tissue invasion in cancer, the activity of MMPs in angiogenesis, inflammation, and development is regulated by inhibitors such as RECK and TIMPs. RECK expression is inhibited by ras, suggesting one component by which ras induces transformation. High levels of RECK expression in tumors is correlated with cancer patient survival and overexpression of RECK may offer a therapeutic strategy for the control of cancer. (This definition may be outdated - see the DesignNote.)
MCID: MC00524102
PMOID: PMO:00014838
Subclass_of: Regulatory Pathway
Synonym: Inhibition of Matrix Metalloproteinases
Tree Number: T4.8.31
database_cross_reference: NCI:C39219
database_cross_reference: NCI_BioC:C39219

Integrin Angiogenesis Pathway
type: Class
subclass of: Regulatory Pathway
MCID: MC01393682
PMOID: PMO:00014839
Subclass_of: Regulatory Pathway
Synonym: Integrins in angiogenesis
Tree Number: T4.8.32
database_cross_reference: NCI:C91627
database_cross_reference: NCI_PID:C91627

Osteopontin-Mediated Signaling Pathway
type: Class
subclass of: Integrin Angiogenesis Pathway
MCID: MC01393874
PMOID: PMO:00014840
Subclass_of: Integrin Angiogenesis Pathway
Synonym: Osteopontin-mediated events
Tree Number: T4.8.32.1
database_cross_reference: NCI:C91641
database_cross_reference: NCI_PID:C91641

MAP Kinase Downregulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk networks. A closely studied Map kinase cascade originates with tyrosine kinase activation, and activation of Ras. Ras activates Raf, Raf activates the Map kinase kinases Mek1 and Mek2 and these kinases activate downstream Map kinases like Erk1 and Erk2. Erk1 and Erk2 in turn activate transgenes like p35 through the Map kinase activated transcription factor EGR-1. Mek1 plays a central role in many different Map kinase pathways. Factors that activate Mek1 include growth factors like NGF, cytokines, chemokines, and phorbol ester, resulting in cellular proliferation and survival. Mek1 activation may also play a role in differentiation in neuronal tissues. In cultured neuronal PC-12 cells, NGF induces neurite outgrowth via Mek1 and the map kinase pathway. Constitutive activation of Mek1 can transform cells and may play a role in cancer. The crucial role of Mek1 in a variety of pathways including cellular transformation suggests that the cell must tightly regulate its activity. Cdk5 is a kinase that regulates the activity of Mek1. Although Cdk5 is a member of the cyclin-dependent kinase gene family, the activity of Cdk5 does not appear to be regulated by cyclins, but is activated by association with p35. Cdk5 does not act as a checkpoint kinase to regulate cell cycle progression, but acts as a regulatory kinase involved in other post-mitotic processes such as neuronal activity such as neuronal migration during development and neurite outgrowth. Mice lacking Cdk5 exhibit defects in neuronal development. One target of Cdk5 is Mek1. Phosphorylation of Mek1 by Cdk5 represses Mek1 activity and blocks downstream cellular responses. The activation of p35 by Map kinase pathways followed by deactivation of Map kinase signaling by the Cdk5/p35 complex completes the loop of a feedback circuit to terminate Map kinase signaling. (This definit…
MCID: MC00527016
PMOID: PMO:00014841
Subclass_of: Regulatory Pathway
Synonym: Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
Tree Number: T4.8.33
database_cross_reference: NCI:C39022
database_cross_reference: NCI_BioC:C39022

Map Kinase Inactivation of SMRT Corepressor Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is represented in this pathway. The EGF receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by either pathway causes SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF. (This definition may be outdated - see the DesignNote.)
MCID: MC00524200
PMOID: PMO:00014842
Subclass_of: Regulatory Pathway
Synonym: Map Kinase Inactivation of SMRT Corepressor
Tree Number: T4.8.34
database_cross_reference: NCI:C39059
database_cross_reference: NCI_BioC:C39059

MAP Kinase Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and mediate a number of physiological and pathological changes in cell function. There are three major subgroups in the MAPK family: ERK, p38, and JNK/SAPK. ERK is activated mainly by mitogenic stimuli, whereas p38 and JNK/SAPK are activated mainly by stress stimuli or inflammatory cytokines. MAP kinases are part of a three-tiered phosphorylation cascade and MAP kinase phosphorylation on a threonine and tyrosine residue located within the activation loop of kinase subdomain VIII results in activation. However, this process is reversible even in the continued presence of activating stimuli, indicating that protein phosphatases provide an important mechanism for MAP kinase control. Dual specificity phosphatases (DSPs) from the tyrosine phosphatase (PTP) gene superfamily are selective for dephosphorylating the critical phosphothreonine and phosphotyrosine residues within MAP kinases. Ten members of dual specificity phosphatases specifically acting on MAPKs, termed MAPK phosphatases (MKPs), have been reported. They share sequence homology and are highly specific for MAPKs but differ in the substrate specificity, tissue distribution, subcellular localization, and inducibility by extracellular stimuli. MKPs have been shown to play important roles in regulating the function of the MAPK family. DSP gene expression is induced strongly by various growth factors and/or cellular stresses. Expression of some gene family members, including CL100/MKP-1, hVH-2/MKP-2, and PAC1, is dependent at least in part on MAP kinase activation providing negative feedback for the inducing MAP kinase or for regulatory cross talk between parallel MAP kinase pathways. DSPs are localized to different subcellular compartments and certain family members appear highly selective for inactivating distinct MAP kinase isoforms. This enzymatic specificity is due to catalytic activati…
MCID: MC00527017
PMOID: PMO:00014843
Subclass_of: Regulatory Pathway
Synonym: Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases
Tree Number: T4.8.35
database_cross_reference: NCI:C39053
database_cross_reference: NCI_BioC:C39053

Mitotic Spindle Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes are not just passengers along for a ride with the spindle, but active participants in the nucleation and stabilization of spindle microtubules in their near vicinity. The ras-like GTPase Ran that regulates nucleocytoplasmic transport through the nuclear pore complex (NPC) during interphase also regulates the formation of the mitotic spindle. Ran plays a similar role in each of these processes, regulating downstream signaling pathways in a differential manner based on whether GDP or GTP is bound. Like other GTPases, the inherent GTPase activity of Ran is regulated by GTPase activating proteins (GAPs) and by exchange factors. An exchange factor that stimulates nucleotide exchange by the Ran GTPase is RCC1, which binds to chromatin in both interphase and mitosis. While RCC1 helps RAN drive transport between the nucleus and cytoplasm during interphase, the localization of RCC1 on chromatin during mitosis localizes Ran-GTP near chromosomes, localizing microtubule formation in these regions. Ran-BP1 and Ran-GAP1 stimulate GTP hydrolysis by Ran, converting it back to Ran-GDP further away from chromosomes. Aster promoting activities (APA) and the importin-alpha and importin-beta proteins involved with Ran in nucleocytoplasmic transport are also involved in mitotic spindle formation. Aster promoting activities stabilize microtubules during spindle formation, but binding of importins to APA neutralizes their activity in forming microtubules. The importins bind to APA when far from the chromosomes, where Ran-GDP predominates, but Ran-GTP near chromosomes causes importins to release APA factors including Tpx2 and NuMa, allowing them to stimulate microtubule formation. Tpx2 interacts with the microtubule motor protein Xklp2 and also activates the Aurora A mitotic kinase, required for spindle formation. In addition to regulating spi…
MCID: MC00524427
PMOID: PMO:00014844
Subclass_of: Regulatory Pathway
Synonym: Role of Ran in mitotic spindle regulation
Tree Number: T4.8.36
database_cross_reference: NCI:C39213
database_cross_reference: NCI_BioC:C39213

Obesity and Thermogenesis Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPAR-gamma is a member of this gene family that is activated by fatty acids and thiazolidinedione drugs that plays a role in insulin sensitivity and adipogenesis. Like PPAR-alpha and other members of this gene family, PPAR-gamma activates transcription in concert with coactivators including Src-1 and Tif2. Although these coactivators act for multiple members of this gene family, coactivators may have specific functions in some settings. Deletion of the Src-1 gene or Tif2 gene in mice reduced the response to steroid hormones and development dependent on these hormones. Some PPAR-gamma ligands induce the specific recruitment of coactivators, and might evoke different functional responses based on the interactions they favor. The natural ligand 15-deoxy prostaglandin J2 stimulated PPAR-gamma interaction with SRC-1, TIF2, TRAP220, and p300, while the synthetic PPAR-gamma ligand troglitazone, an antidiabetic thiazolidinedione drug, did not promote these interactions, indicating that other distinct coactivators may mediate the response to PPAR-gamma when it binds this ligand. In normal rodents, a high-fat diet leads to high levels and free fatty acids and PPAR-gamma activation in white adipose tissue, stimulating fat uptake, adipogenesis and obesity. PPAR-gamma activation in brown adipose tissue depends mainly on Src-1 as a coactivator and Src-1 is essential for PGC-1 alpha to act as a coactivator to stimulate thermogenesis. Regulation of energy use by PGC-1 in other tissues such as muscle may contribute to weight loss associated with cancer and increased metabolism induced by exercise. High-fat feeding and high plasma free fatty acids reduce thermogenesis in brown fat due to the greater requirement of PPAR-gamma for Src-1 than Tif2 for activation in these cells. In white adipose cells, Tif2 predominates as the PPAR-gamma coactivator, stimulating fat …
MCID: MC00527215
PMOID: PMO:00014845
Subclass_of: Regulatory Pathway
Synonym: Role of PPAR-gamma Coactivators in Obesity and Thermogenesis
Tree Number: T4.8.37
database_cross_reference: NCI:C39198
database_cross_reference: NCI_BioC:C39198

Oocyte Meiosis Pathway
type: Class
subclass of: Regulatory Pathway
Definition: During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle.
MCID: MC01394335
PMOID: PMO:00014846
Subclass_of: Regulatory Pathway
Synonym: Oocyte meiosis
Tree Number: T4.8.38
database_cross_reference: NCI:C91472
database_cross_reference: NCI_KEGG:C91472

p53 Pathway for Transcriptional Regulation
type: Class
subclass of: Regulatory Pathway
MCID: MC01394097
PMOID: PMO:00014847
Subclass_of: Regulatory Pathway
Synonym: p53 pathway
Tree Number: T4.8.39
database_cross_reference: NCI:C91571
database_cross_reference: NCI_PID:C91571

p53 Effector Pathway
type: Class
subclass of: p53 Pathway for Transcriptional Regulation
MCID: MC01394098
PMOID: PMO:00014848
Subclass_of: p53 Pathway for Transcriptional Regulation
Synonym: Direct p53 effectors
Tree Number: T4.8.39.1
database_cross_reference: NCI:C91572
database_cross_reference: NCI_PID:C91572

PGC1a Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for energy metabolism and energy homeostasis. Inappropriate increases in PGC-1a activity have been linked to a number of pathological conditions including heart failure and diabetes. PGC-1a is highly expressed in metabolically active tissues including brown fat, skeletal muscle and heart. PGC-1a has been implicated in mitochondrial biogenesis in the heart and increased mitochondrial respiration in brown fat. PGC-1a is a coactivator for many factors including, CBP, Scr-1, PPARa, glucocorticoid receptor, thyroid hormone receptor, several orphan receptors, and MEF2. This pathway illustrates two of the cofactor regulatory factors, MEF2 and PPARa, and an example orphan receptor feedback inhibition loop. Glut4 is used as an example of the downstream elements leading to changes in metabolism. Ichida et al discovered the ERRa repression of PGC-1a. Their results suggest a novel mechanism of transcriptional control wherein ERR-a can function as a specific molecular repressor of PGC-1a. This suggests that other co-activators might also have specific repressors, adding another layer of combinatorial complexity in transcriptional regulation. Czubryt et al identified PGC-1a as a key target of the MEF2/HDAC regulatory pathway and demonstrated this pathway's importance in maintenance of cardiac mitochondrial function. The linking of MEF2/HDAC provides a potential explanation for the increase in mitochondrial number observed in response to CaMK signaling. (This definition may be outdated - see the DesignNote.)
MCID: MC00527342
PMOID: PMO:00014849
Subclass_of: Regulatory Pathway
Synonym: Regulation of PGC-1a
Tree Number: T4.8.40
database_cross_reference: NCI:C39188
database_cross_reference: NCI_BioC:C39188

Phosphoinositide Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Nine currently identified phosphoinositide 3-kinases (PI 3-K) constitute a subfamily of lipid kinases that catalyze the addition of a phosphate molecule on the 3-position of the inositol ring of phosphoinositides. Phosphatidylinositol (PtdIns), the precursor of all phosphoinositides (PI), constitutes less than 10% of the total lipid in eukaryotic cell membranes. Approximately 5% of cellular PI is phosphorylated at the 4-position (PtdIns-4-P), and another 5% is phosphorylated at both the 4- and 5-positions (PtdIns-4, 5-P2). However, less than 0.25% of the total inositol-containing lipids are phosphorylated at the 3-position, consistent with the idea that these lipids exert specific regulatory functions inside the cell, as opposed to a structural function. Here we have chosen to highlight a group of the phosphoinositide targets of the PI3-Ks and their downstream targets. The downstream effects of these PI-3 targets are indicated, illustrating the important role the PI3Ks have in cell function and survival. (This definition may be outdated - see the DesignNote.)
MCID: MC00527467
PMOID: PMO:00014850
Subclass_of: Regulatory Pathway
Synonym: Phosphoinositides and their downstream targets
Tree Number: T4.8.41
database_cross_reference: NCI:C39204
database_cross_reference: NCI_BioC:C39204

Pitx2 Transcription Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordinated transcriptional control of proliferation in specific developmental cell types is crucial in multiple developmental settings. One of a family of three bicoid-related transcription factors, Pitx2 acts downstream of the extracellular signaling protein Wnt to drive proliferation of cells with specific developmental fates, including cells in the pituitary, cardiac outflow region, and muscle. Wnt binds to Frizzled, a G-protein coupled receptor, activating homologs of the Drosophila Disheveled protein. Activation of Frizzled and Disheveled inhibits the kinase GSK-3 beta, part of a protein complex in the absence of Wnt signaling, causing beta-catenin protein to accumulate in the cytoplasm. Beta-catenin is known to alter the function of transcription factors like TCF/Lef. One result of Wnt signaling is activation of the transcription factor Lef by beta-catenin, inducing Pitx2 expression. Wnt activation also changes Pitx2 from a repressor to an activator by causing transcriptional corepressors like histone deacetylase 1 (HDAC1) bound to Pitx2 to be exchanged for coactivators. With coactivators bound, Pitx2 activates transcription of genes that regulate the cell cycle, such as Cyclin D2. Different coactivators are recruited by Pitx2 and other transcription factors like Myc to the Cyclin D2 promoter, with CBP/p300 recruited first, followed by NLI/Ldb/CLIM, Tip60/TRRAP, and PBP coactivators. Many of these coactivators help to alter histone acetylation and chromatin structure as part of transcriptional activation. The activation of cell cycle genes by Pitx2 ultimately stimulates the proliferation of specific cell types with the confluence of tissue-specific gene expression, growth factor signaling and coactivator recruitment. (This definition may be outdated - see the DesignNote.)
MCID: MC00524778
PMOID: PMO:00014851
Subclass_of: Regulatory Pathway
Synonym: Multi-step Regulation of Transcription by Pitx2
Tree Number: T4.8.42
database_cross_reference: NCI:C39189
database_cross_reference: NCI_BioC:C39189

PML Transcription Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptosis and are characterized by the presence of the protein PML. The activities of PML as a tumor suppressor and apoptosis inducing factor are exerted through the numerous proteins it interacts with in the PML-nuclear bodies including the tumor suppressor p53. DNA damage-induced activation of p53-dependent apoptosis requires PML. PML acts as a coactivator for p53 and increases acetylation of p53 by the transcriptional coactivator CBP. This acetylation of p53 is reversed by the deacetylase SirT1, the human homolog of the yeast gene Sir2, and this deacetylation opposes the transcriptional activation of p53. The tumor suppressor Rb also interacts with the PML nuclear body, increasing transcriptional repression of genes involved in cell cycle progression, suggesting that PML may affect cellular transformation through more than one mechanism. PML interacts directly with Ubc9, which modifies PML through the attachment of the ubiquitin-like peptide Sumo-1. Sumo-1 modification of PML is not necessary for the nuclear bodies to form, but may affect the recruitment of proteins that interact with PML. PML is involved in non-p53 mediated apoptotic pathways, such as DAXX-mediated apoptosis induced by Fas and TNF and regulates the transcriptional repressor activity of Daxx. The sequestration of Daxx by the PML nuclear bodies relieves the repression of other transcription factors like Pax3 by Daxx. Tumor suppression by PML may in general involve the formation of specific regulatory transcription complexes, including those with DAXX, p53 and CBP. Factors that affect the assembly of PML into the PML nuclear bodies affect the proliferation and transformation of cells. Viral early proteins can interact with PML to disrupt the nuclear bodies, allowing increased proliferation of cells and reduced apoptosis, good conditions for DNA virus infecti…
MCID: MC00527703
PMOID: PMO:00014852
Subclass_of: Regulatory Pathway
Synonym: Regulation of transcriptional activity by PML
Tree Number: T4.8.43
database_cross_reference: NCI:C39196
database_cross_reference: NCI_BioC:C39196

PPAR-alpha Gene Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: The most recognized mechanism by which peroxisome proliferators regulate gene expression is through a PPAR/RXR heterodimeric complex binding to a peroxisome proliferator-response element (PPRE) (classical mechanism). However, there is the possibility of several variations on this theme: 1) the peroxisome proliferator interacts with PPAR that preexists as a DNA complex with associated corepressors proteins. The interaction with ligand causes release of the corepressor and association with a coactivator, resulting in the classical mechanism. 2) the peroxisome proliferator interacts with PPAR as a soluble member of the nucleus. The binding of ligand results in RXR heterodimerization, DNA binding and coactivator recruitment. 3) in this scenario, PPAR exists in the cytosol, perhaps complexed to heat shock protein 90 and/or other chaperones. Binding of peroxisome proliferator causes a conformational change and translocation into the nucleus. Scenarios 4 and 5 require regulation of gene expression via non-classical mechanisms: 4) PPAR is capable of interacting with, and forming DNA binding heterodimers with, several nuclear receptors including the thyroid hormone receptor. The binding site for this non-RXR heterodimer need not be the classic DR-1 motif found in the PPRE. 5) PPAR may participate in the regulation of gene expression without binding to DNA. By association with transcription factors such as c-jun or p65, PPAR diminishes the ability of AP1 or NFB to bind to their cognate DNA sequences, respectively. Also shown in this scheme are two means to modify the peroxisome proliferator response. Most importantly, growth factor signaling has a pronounced affect on PPAR via post-translational modification. PPAR is a phosphoprotein and its activity is affected by insulin. Several kinase pathways affect PPARa's activity, although the specific kinases and phosphorylation sites have not been conclusively determined. (This definition may be outdated - see the DesignNote.)
MCID: MC00527354
PMOID: PMO:00014853
Subclass_of: Regulatory Pathway
Synonym: Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
Synonym: PPARA Gene Regulation Pathway
Tree Number: T4.8.44
database_cross_reference: NCI:C39197
database_cross_reference: NCI_BioC:C39197

Protein Activation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: A sequence of biological or biochemical events that are involved in the manifestation of the activity of a protein.
MCID: MC01394284
PMOID: PMO:00014854
Subclass_of: Regulatory Pathway
Synonym: Positive Regulation of Protein Activity Pathway
Tree Number: T4.8.45
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C40420

Extrinsic Prothrombin Activation Pathway
type: Class
subclass of: Protein Activation Pathway
Definition: Blood coagulation takes place in 3 essential phases. The first phase is the activation of a prothrombin activator complex. The second phase is the activation of prothrombin. The third stage is clot formation as a result of fibrinogen cleavage by activated thrombin. The prothrombin activation complex is formed by two pathways each of which results in a different form of the prothrombin activator. The extrinsic mechanism of prothrombin activator formation begins with trauma to vascular walls or extravascular tissues. The damaged tissue releases tissue thromboplastin also known as tissue factor (TF). The formation of a clot by this mechanism usually takes as little as 15 seconds. This cascade is initiated by the activation of factor X by TF and factor VII. Activated factor X combined with factor V, factor VII and TF constitutes the prothrombin activator. Calcium (Ca++) is required for each of these steps. The prothrombin activator in the extrinsic pathway is very similar to the activator in the intrinsic pathway. Antithrombin III inhibits the activity of thrombin and also the step leading to the activation of factor X. Antithrombin III is a hundred to a thousand times more effective when bound by heparin. Protein C is activated by thrombin and with the Protein S cofactor provides a strong negative feedback in this phase of clot formation. (This definition may be outdated - see the DesignNote.)
MCID: MC00526423
PMOID: PMO:00014855
Subclass_of: Protein Activation Pathway
Tree Number: T4.8.45.1
database_cross_reference: NCI:C39076
database_cross_reference: NCI_BioC:C39076

Intrinsic Prothrombin Activation Pathway
type: Class
subclass of: Protein Activation Pathway
Definition: Blood coagulation or clotting takes place in 3 essential phases. The first phase is the activation of a prothrombin activator complex. The second phase is the activation of prothrombin. The third stage is clot formation as a result of fibrinogen cleavage by activated thrombin. The prothrombin activation complex is formed by two pathways each of which results in a different form of the prothrombin activator. The intrinsic mechanism of prothrombin activator formation begins with trauma to the blood or exposure of blood to collagen in a traumatized vessel wall. This usually also results in damage to fragile platelets. The formation of a clot by this mechanism usually takes 1 to 6 minutes. This cascade begins with the activation of factor XII and the release of platelet factor 3 (PF3) from damaged platelets. Activated factor XII cleaves and actives factor XI and prekallikrein (PK). Factor XII is also activated by activated prekallikrein (aPK) in an internal amplification loop. Calcium (Ca++) is required for the initial three steps. The prothrombin activator in the intrinsic pathway is very similar to the activator in the extrinsic pathway. Antithrombin III inhibits the activity of thrombin and also two of the steps in the formation of the activator. Protein C is activated by thrombin and with the Protein S cofactor provides a strong negative feedback in this phase of clot formation. (This definition may be outdated - see the DesignNote.)
MCID: MC00526700
PMOID: PMO:00014856
Subclass_of: Protein Activation Pathway
Tree Number: T4.8.45.2
database_cross_reference: NCI:C39132
database_cross_reference: NCI_BioC:C39132

MAP Kinase Activation Pathway
type: Class
subclass of: Protein Activation Pathway
Definition: The binding of b-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using b-arrestin as a scaffold, with subsequent activation of a b-arrestin-bound pool of ERK1/2. The receptor-b-arrestin-ERK complexes are localized to endosomal vesicles, and their formation does not result in nuclear translocation of activated ERK1/2 or stimulation of cell proliferation. The function of b-arrestin-bound ERK1/2 is presently unknown. Activation of ERK1/2 by b-arrestin scaffolds may favor the phosphorylation of plasma membrane, cytosolic, or cytoskeletal ERK1/2 substrates, or it may lead to transcriptional activation through the ERK-dependent activation of other kinases. The model depicts b-arrestin scaffolding of the ERK1/2 MAP kinase cascade, based upon data obtained with the protease-activated PAR2 and angiotensin AT1a receptors. A similar mechanism has been proposed for regulation of the JNK3 MAP kinase cascade by AT1a receptors. (This definition may be outdated - see the DesignNote.)
MCID: MC00527015
PMOID: PMO:00014857
Subclass_of: Protein Activation Pathway
Synonym: Role of beta-arrestins in the activation and targeting of MAP kinases
Tree Number: T4.8.45.3
database_cross_reference: NCI:C39002
database_cross_reference: NCI_BioC:C39002

PPAR Pathway
type: Class
subclass of: Protein Activation Pathway
Definition: Similar to other nuclear hormone receptors, PPAR acts as a ligand activated transcription factor. Upon binding fatty acids or hypolipidemic drugs, PPARa interacts with RXR and regulates the expression of target genes. These genes are involved in the catabolism of fatty acids. Conversely, PPARg is activated by prostaglandins, leukotrienes, and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPARb is only weakly activated by fatty acids, prostaglandins, and leukotrienes and has no known physiologically relevant ligand. However, data from PPARb null mice suggest PPARb does serve a role in fatty acid metabolism and perhaps in skin proliferation and cancer. (This definition may be outdated - see the DesignNote.)
MCID: MC00527353
PMOID: PMO:00014858
Subclass_of: Protein Activation Pathway
Synonym: Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression
Tree Number: T4.8.45.4
database_cross_reference: NCI:C39199
database_cross_reference: NCI_BioC:C39199

Protein Kinase A Activation Pathway
type: Class
subclass of: Protein Activation Pathway
Definition: G-protein coupled receptors (GPCRs) comprise one of the largest gene families of signaling proteins. Residing in the plasma membrane with seven transmembrane domains, GPCRs respond to extracellular stimuli that include catecholamine neurotransmitters, neuropeptides, larger protein hormones, lipids, nucleotides and other biological molecules. When a GPCR binds its extracellular ligand, it interacts with a G-protein to transduce a signal across the membrane into the cellular interior. G-proteins are a heterotrimeric complex containing a Ga subunit with GTPase activity, as well as b and g subunits. Ga can exist in an active state and an inactive state. Ga in the off state has GDP bound and does not activate downstream signaling molecules. When a GPCR is activated by ligand, it stimulates Ga subunits to bind GTP instead of GDP and become active, dissociating from the receptor and from the b/g subunits to activate downstream signaling factors like the enzyme adenylyl cyclase that synthesizes cyclic-AMP (cAMP) from ATP. Ga turns itself back off again with its intrinsic GTPase activity, hydrolyzing GTP to GDP to become inactive. Activated G proteins interact with downstream signaling factors to alter the production of second messenger signaling molecules like inositolphosphates, calcium and cAMP. GPCRs that activate the Gi class of Ga subunits inhibit cAMP production and GPCRs that activate the Gs class of Ga subunits activate cAMP production. cAMP in turn activates the cAMP-dependent protein kinase, protein kinase A (PKA). PKA is a tetramer composed of catalytic subunits and regulatory subunits that repress the catalytic units when they are bound together. The regulatory subunits bind cAMP when it is present and release the catalytic units, releasing their inhibition of the catalytic subunits as well. The catalytic subunits of PKA when they are released and active phosphorylate target substrate proteins on serine and threonine residues, altering the activity of the modifi…
MCID: MC00525024
PMOID: PMO:00014859
Subclass_of: Protein Activation Pathway
Synonym: Activation of cAMP-dependent protein kinase, PKA
Tree Number: T4.8.45.5
database_cross_reference: NCI:C39099
database_cross_reference: NCI_BioC:C39099

Protein Kinase C Activation Pathway
type: Class
subclass of: Protein Activation Pathway
Definition: G-protein coupled receptors (GPCRs) transduce a variety of signals from the extracellular environment across the plasma membrane. One of the common signaling systems utilized by GPCRs activates protein kinase C (PKC), a ubiquitous family of serine/threonine protein kinases. The pathway leading to PKC activation starts with a class of GPCRs that interact with and activate Gq G-proteins when the receptor has agonist ligand bound. GPCRs that act through Gq include some muscarinic acetylcholine receptors, many peptide receptors, and the 5-HT2 serotonin receptors. Activated Gq with GTP bound activates its downstream target phospholipase C (PLC) to hydrolyze the membrane lipid PIP2, producing IP3 and diacylglycerol (DAG). IP3 is water-soluble and diffuses through the cytoplasm to the ER, where it binds to and opens a calcium channel, releasing calcium stores from inside the ER into the cytoplasm. Calcium alters many cellular processes, in part by binding to regulatory proteins such as calmodulin and calcineurin. The interaction of both DAG and calcium with PKC activates its kinase activity and the phosphorylation of many different protein targets alters their activity. The involvement of PKC in cellular proliferation and the cell cycle is indicated by the activity of tumor promoters like phorbol esters as PKC activators. (This definition may be outdated - see the DesignNote.)
MCID: MC00525025
PMOID: PMO:00014860
Subclass_of: Protein Activation Pathway
Synonym: Activation of PKC through G protein coupled receptor
Tree Number: T4.8.45.6
database_cross_reference: NCI:C39190
database_cross_reference: NCI_BioC:C39190

SRC Tyrosine Kinase Activation Pathway
type: Class
subclass of: Protein Activation Pathway
Definition: Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a protein tyrosine kinase. Overexpression of Src leads to tyrosine phosphorylation of multiple protein substrates and cellular transformation. During interphase the Src protein folds back upon itself to stay in the inactive state, with a phosphotyrosine residue in one domain at Tyrosine 529 bound by an SH2 domain in the same protein. Activation of c-Src involves protein-tyrosine phosphatase alpha (PTP-alpha, or RPTP-alpha), a transmembrane protein with a cytoplasmic phosphatase domain. A variety of evidence has indicated that PTP-alpha dephosphorylates c-Src at Tyr529, allowing Src to open up and become activated, and that this activation occurs in association with mitosis. To activate Src, PTP-alpha must first open up the folded Src through binding itself to the phosphorylated Src domain, a process blocked by binding of Grb-2 to PTP-alpha at phosphorylated Tyr789. PTP-alpha phosphorylated at Tyr789 also binds to the Src SH2 domain, causing the Src structure to open at Src Tyr529 to become available for dephosphorylation. During mitosis the mitotic kinase Cdc-2 phosphorylates Src, along with other cellular substrates, and in so doing makes Src more prone to PTP-alpha dephosphorylation and activation. The activity of PTP-alpha toward Src is also regulated by phosphorylation of PTP-alpha by protein kinase C at serines 180 and 204, releasing the inhibition of PTP-alpha by Grb-2. In the normal cell cycle, Src activity is down-regulated after cell division through dephosphorylation by protein phosphatases and phosphorylation by Csk (C-terminal src kinase) and PTP-alpha dephosphorylation returns the cycle to its interphase condition. The regulation of Src activity during mitosis demonstrates how protein phosphorylation can shift the delicate equilibrium of molecular interactions and cellular responses. (This definition may be outdated - see the DesignNote.)
MCID: MC00527515
PMOID: PMO:00014861
Subclass_of: Protein Activation Pathway
Synonym: Activation of Src by Protein-tyrosine phosphatase alpha
Tree Number: T4.8.45.7
database_cross_reference: NCI:C39237
database_cross_reference: NCI_BioC:C39237

SRF Activation Pathway
type: Class
subclass of: Protein Activation Pathway
Definition: Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including immediate early genes such as c-fos, fosB, junB, egr-1 and -2, neuronal genes such as nurr1 and nur77, and muscle genes such as actins and myosins. By regulating expression of these genes, SRF controls cell growth and differentiation, neuronal transmission, as well as muscle development and function. SRF can be activated by serum, lysophosphatidic acid (LPA), lipopolysaccharide (LPS), 12-O-tetradecanoylphorbol-13-acetate (TPA), cytokines, tumor necrosis factor-alpha (TNFalpha), agents that increase intracellular Ca2+, T-cell virus1 activator protein, hepatitis B virus activator proteins pX, activated oncogenes and protooncogenes, and extracellular stimuli such as antioxidant and UV light. In serum-starved cells, MAL is predominantly cytoplasmic where it is sequestered by actin monomers. Upon serum stimulation, Rho becomes active and, through its interaction with ROCK and mDia1, causes an accumulation of F-actin and a commensurate decrease in the level of G-actin. As a consequence, MAL is no longer sequestered and is free to translocate to the nucleus where it associates with SRF and activates SRE-mediated gene expression. (This definition may be outdated - see the DesignNote.)
MCID: MC00527516
PMOID: PMO:00014862
Subclass_of: Protein Activation Pathway
Synonym: Role of MAL in Rho-Mediated Activation of SRF
Tree Number: T4.8.45.8
database_cross_reference: NCI:C39145
database_cross_reference: NCI_BioC:C39145

RANBP2-Mediated Sumoylation Transcription Regulation Pathway
type: Class
subclass of: Regulatory Pathway
MCID: MC00815386
PMOID: PMO:00014863
Subclass_of: Regulatory Pathway
Synonym: Sumoylation by RanBP2 regulates transcriptional repression
Tree Number: T4.8.46
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91685
database_cross_reference: NCI_PID:C91685

Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway
type: Class
subclass of: Regulatory Pathway
MCID: MC01393795
PMOID: PMO:00014864
Subclass_of: Regulatory Pathway
Synonym: Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Tree Number: T4.8.47
database_cross_reference: NCI:C91660
database_cross_reference: NCI_PID:C91660

Regulation of Nuclear SMAD2/3 Signaling Pathway
type: Class
subclass of: Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway
MCID: MC01393797
PMOID: PMO:00014865
Subclass_of: Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway
Synonym: Regulation of nuclear SMAD2/3 signaling
Tree Number: T4.8.47.1
database_cross_reference: NCI:C91661
database_cross_reference: NCI_PID:C91661

RELA Pathway
type: Class
subclass of: Regulatory Pathway
Definition: The rel/NF-kB family of transcription factors regulates the activity of genes involved in the immune response, hematopoiesis, and inflammation. NF-kB is a complex of two proteins, p65 (rel) and p50. NF-kB is held inactive in the cytoplasm by I-kB, until signals initiated by TNF or several other factors lead to the phosphorylation and degradation of I-kB and the subsequent release of NF-kB to bind DNA and activate genes. The activation of transcription by NF-kB requires transcriptional coactivators such as p300 and CBP to interact with the rest of the transcriptional apparatus. These coactivators posses enzyme activity, acting to catalyze the posttranslational acetylation of proteins on lysine groups. Acetylation of histones has been known for some time to occur in transcriptionally active chromatin regions. Histone deacetylase (HDAC) enzymes reverse the acetylation of histones. As with other signals, there an off-switch as well as an on-switch for NF-kB activation. The signal to terminate gene activation by NF-kB involves regulation of NF-kB acetylation. P300 and CBP recruited by NF-kB to the transcriptional complex acetylate RelA. Acetylated NF-kB proteins do not interact with I-kB and so continue stimulating transcription. To turn off NF-kB dependent transcription, the histone deacetylase HDAC3 binds to and deacetylates RelA, which then interacts strongly with I-kB once again and is inactivated. The reformed complex of NF-kB and I-kB is exported from the nucleus to the cytoplasm where it replenishes the pool of inactive NF-kB awaiting the next activation signal. The activity of other proteins may also be regulated by acetylation in a similar manner. (This definition may be outdated - see the DesignNote.)
MCID: MC00525065
PMOID: PMO:00014866
Subclass_of: Regulatory Pathway
Synonym: Acetylation and Deacetylation of RelA in The Nucleus
Tree Number: T4.8.48
database_cross_reference: NCI:C39221
database_cross_reference: NCI_BioC:C39221

Spermatogenesis Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcriptional activation of post-meiotic genes involved in this process such as calspermin and testis angiotensin-converting enzyme. The key role of CREM in sperm formation is demonstrated by the male sterility of mice lacking CREM, the failure of spermatids to develop into mature sperm, and a lack of post-meiotic gene expression in these animals. Prior to meiosis, splice variants of CREM act as antagonists of cAMP-dependent transcriptional activation, but coordinate with spermatogenesis, the potent transcriptional activator CREM tau splice variant is highly expressed. In other tissues CREM activates genes in response to cAMP through phosphorylation and CBP association, but transcriptional activation by CREM in male germ cells is CBP independent. Stimulation of spermatids with follicle-stimulating hormone (FSH) induces cAMP formation, and the association of CREM with the coactivator ACT, although the mechanism regulating the interaction of CREM with ACT is not yet known. A two-hybrid screen looking for ACT interacting factors revealed another surprising component regulating CREM, the kinesin Kif17b. Kinesins are molecular motors that interact with microtubules to transport organelles and other material within the cell. Kif17b is actively exported from the nucleus in a Crm1-dependent manner, so when it is bound to ACT the export of Kif17b excludes CREM-ACT from the nucleus and blocks transcriptional activation by this complex. The mechanism regulating the interaction of Kif17b with ACT to drive CREM activation is not yet known. Although the regulation of transcription by a kinesin is surprising, a functional connection between cytoskeletal elements and transcriptional regulation is not unprecedented, as demonstrated by the transcription factor MIZ-1 that regulates transcription in response to changes in microtubule structure. (Thi…
MCID: MC00527643
PMOID: PMO:00014867
Subclass_of: Regulatory Pathway
Synonym: Regulation of Spermatogenesis by CREM
Tree Number: T4.8.49
database_cross_reference: NCI:C39037
database_cross_reference: NCI_BioC:C39037

Stathmin Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Stathmin is a ubiquitous, cytosolic 19-kDa protein, that is phosphorylated on up to four sites in response to many regulatory signals within cells. Its molecular characterization indicates a functional organization including an N-terminal regulatory domain that bears the phosphorylation sites linked to a putative alpha-helical binding domain predicted to participate in coiled-coil, protein-protein interactions. In addition to the protein kinases that phosphorylate Stathmin such as CaMK, MAPK, p34cdc2, PKA, a few other proteins have been suggested to interact with stathmin in vivo. One of them was identified as BiP, a member of the hsp70 heat-shock protein family. Another is a previously unidentified, putative serine/threonine kinase, KIS, which might be regulated by stathmin or, more likely, be part of the kinases controlling its phosphorylation state. Finally, proteins CC1 and CC2, predicted to form alpha-helices participating in coiled-coil interacting structures. It has been suggest that the action of antimicrotubule drugs can be affected by stathmin in at least two ways: (a) altered drug binding; and (b) growth arrest at the G2 to M boundary. Mutant p53 breast cancers exhibiting high levels of stathmin may be resistant to antimicrotubule agents. (This definition may be outdated - see the DesignNote.)
MCID: MC00525228
PMOID: PMO:00014868
Subclass_of: Regulatory Pathway
Synonym: Stathmin and breast cancer resistance to antimicrotubule agents
Tree Number: T4.8.50
database_cross_reference: NCI:C39239
database_cross_reference: NCI_BioC:C39239

Sumoylation in Modulation of CtBP-Dependent Gene Response Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Covalent attachment of one eukaryotic protein to another is a prominent posttranslational modification and Ubiquitin is the most familiar of the protein modifiers. Recently a new group of ubiquitin-like (Ubl) proteins have come to light. One of the most intriguing of them is SUMO (small ubiquitin-like modifier, 12kDa) also known as Sentrin. SUMO family has been described in vertebrates: SUMO-1 and the closest homologs SUMO-2 and SUMO-3. SUMO have been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, CtBP, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. In the case of the transcription co-repressor CtBP, which can be recruited to the target promoter via interaction with a conserved PxDLS motif in the interacting repressor, CtBP SUMOylation profoundly affected its subcellular localization. SUMOylation occurred at a single Lys residue, Lys428, of CtBP1. Mutating Lys428 into Arg (K428R) shifted CtBP1 from the nucleus to the cytoplasm, while it had little effect on its interaction with the PxDLS motif. The K428R mutation also abolished the ability of CtBP1 to repress the E-cadherin promoter activity. Consistent with the known inhibitory effect of nNOS on the nuclear accumulation of CtBP1, PDZ domain of nNOS inhibits the SUMOylation of CtBP1. The current data indicates that SUMOylation can regulate CtBP1-dependent transcriptional repression. (This definition may be outdated - see the DesignNote.)
MCID: MC00525273
PMOID: PMO:00014869
Subclass_of: Regulatory Pathway
Synonym: SUMOylation as a mechanism to modulate CtBP-dependent gene responses
Tree Number: T4.8.51
database_cross_reference: NCI:C39039
database_cross_reference: NCI_BioC:C39039

Sumoylation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Like ubiquitin, SUMO (small ubiquitin-related modifier) proteins are small protein tags that are conjugated to proteins to modify their function. The ubiquitin system tags proteins for degradation by the proteasome but SUMO conjugation has a range of other functions, stabilizing some proteins and altering their subcellular localization. Sumoylation may also influence ubiquitination and protein stability indirectly. Three different SUMO proteins are conjugated to proteins, SUMO-1, SUMO-2 and SUMO-3. The SUMO-2 and SUMO-3 genes are closely related, with 86% sequence identity while SUMO-1 is less closely related with about 50% sequence identity with SUMO-2 and SUMO-3. These SUMO proteins also have distinct functions, with SUMO-1 conjugated to proteins as a monomer, while SUMO-2 and SUMO-3 are conjugated to proteins as higher molecular weight polymers with SUMO-1 terminating further SUMO addition. SUMO proteins are first activated by adenylation by one enzyme complex (SAE1/SAE2), then transferred to Ubc-9 and finally to the terminal amino group of a lysine side chain in target proteins. The same conjugation system appears to work for all three SUMO proteins. One target of SUMO modification is proteins involved in formation of the PML nuclear bodies, promoting the stability of these structures and perhaps altering their role in transcriptional regulation, cellular proliferation and anti-viral responses. Other targets of SUMO addition include DAXX, p53 and ran-Gap. The transcriptional activation by p53 is increased by SUMO addition. The localization of DAXX to the PML nuclear bodies and the localization of ran-Gap to the nuclear pores are also regulated by SUMO addition. The activity of several transcription factors is altered by sumoylation, including C/EBP proteins, c-Myb, glucocorticoid receptor, androgen receptor, and progesterone receptor. PIAS is a protein that modulates the activity of many different transcription factors perhaps by acting itself as a sumo ligase. …
MCID: MC00525271
PMOID: PMO:00014870
Subclass_of: Regulatory Pathway
Synonym: Basic Mechanisms of SUMOylation
Tree Number: T4.8.52
database_cross_reference: NCI:C39242
database_cross_reference: NCI_BioC:C39242

Sumoylation Regulation of Transcriptional Repression Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptional repression. (This definition may be outdated - see the DesignNote.)
MCID: MC00525272
PMOID: PMO:00014871
Subclass_of: Regulatory Pathway
Synonym: Sumoylation by RanBP2 Regulates Transcriptional Repression
Tree Number: T4.8.53
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39211
database_cross_reference: NCI_BioC:C39211

Telomerase Regulation Pathway
type: Class
subclass of: Regulatory Pathway
MCID: MC01393804
PMOID: PMO:00014872
Subclass_of: Regulatory Pathway
Synonym: Regulation of Telomerase
Tree Number: T4.8.54
database_cross_reference: NCI:C91664
database_cross_reference: NCI_PID:C91664

Terc Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Telomerase is an enzyme that replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells that have an unlimited replicative capacity, such as male germ cells and the majority of human cancers, have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential RNA subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase RNA gene (hTERC) are controlled at least in part at the transcriptional level. The hTERC gene is expressed at high levels in cancer cells, and is absent or at low levels in some normal tissues. (This definition may be outdated - see the DesignNote.)
MCID: MC00525417
PMOID: PMO:00014873
Subclass_of: Regulatory Pathway
Synonym: Overview of telomerase RNA component gene hTerc Transcriptional Regulation
Tree Number: T4.8.55
database_cross_reference: NCI:C39248
database_cross_reference: NCI_BioC:C39248

Tert Regulation Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Telomerase is an enzyme that replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells that have an unlimited replicative capacity, such as male germ cells and the majority of human cancers, have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential RNA subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase RNA gene (hTERC) are controlled at least in part at the transcriptional level. The hTERT gene is expressed at low levels in cancer cells and is generally undetectable in normal cells. (This definition may be outdated - see the DesignNote.)
MCID: MC00525421
PMOID: PMO:00014874
Subclass_of: Regulatory Pathway
Synonym: Overview of telomerase protein component gene hTert Transcriptional Regulation
Tree Number: T4.8.56
database_cross_reference: NCI:C39249
database_cross_reference: NCI_BioC:C39249

Th2 Cytokine Gene Induction Pathway
type: Class
subclass of: Regulatory Pathway
Definition: CD4+ helper T cells differentiate into distinct subtypes, Th1 and Th2. Th2 cells are involved in the response to extracellular helminth parasites and allergic responses and secrete a distinct set of cytokines including IL-4, IL-5 and IL-13. The development and differentiation of T cells is influenced by many factors, including transcription factors such as GATA-3, a transcription factor associated with induction of Th2 cells. Factors that increase cAMP levels in Th2 cells activate p38 kinase, which phosphorylates and activates GATA-3 independently of PKA. Cells expressing GATA-3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. These cytokines are found in a gene cluster together and are regulated coordinately by GATA-3. Binding of GATA-3 in the regulatory regions of these genes alters chromatin structure, increasing accessibility to other transcription factors. Activation of the T cell receptor through interaction with antigen on antigen presenting cells activates NFAT and other transcription factors that cooperate with GATA-3 in inducing Th2 cell differentiation. Dominant negative GATA-3 can repress the secretion of these cytokines and block the airway inflammation that causes asthma. Blocking GATA-3 action such as through antisense treatment has been suggested as a therapeutic strategy to treat asthma. GATA-3 has also been implicated in developmental processes such as the development of the inner ear. (This definition may be outdated - see the DesignNote.)
MCID: MC00525477
PMOID: PMO:00014875
Subclass_of: Regulatory Pathway
Synonym: GATA3 participate in activating the Th2 cytokine genes expression
Tree Number: T4.8.57
database_cross_reference: NCI:C39090
database_cross_reference: NCI_BioC:C39090

Tight Junction Assembly Pathway
type: Class
subclass of: Regulatory Pathway
Definition: Epithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. The transmembrane proteins mediate cell adhesion and are thought to constitute the intramembrane and paracellular diffusion barriers. The cytoplasmic 'plaque' contains three major multi-protein complexes consisting largely of scaffolding proteins, the ZO protein complex, the CRB3-Pals1-PATJ complex and the PAR-3-aPKC-PAR-6 complex. The ZO protein complex appears to organize the transmembrane proteins and couple them to other cytoplasmic proteins and to actin microfilaments. Two evolutionarily conserved protein complexes, the CRB3 and PAR complexes are involved in the establishment and maintenance of epithelial cell polarity. Besides these three protein complexes which seem to be constitutively associated at TJs, a number of proteins with different functions has been identified at TJs. These include additional scaffolding proteins like MUPP1 and MAGI-1, adaptor proteins, transcription regulators and RNA processing factors, regulatory proteins like small GTPases and G-proteins, kinases and phosphatases, and heat shock proteins. These are proposed to be involved in junction assembly, barrier regulation, gene transcription, and perhaps other, presently undefined pathways.
MCID: MC01394345
PMOID: PMO:00014876
Subclass_of: Regulatory Pathway
Synonym: Tight junction
Tree Number: T4.8.58
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91475
database_cross_reference: NCI_KEGG:C91475

Transport Pathway
type: Class
subclass of: Regulatory Pathway
Definition: An elaboration of the sequence of biological or biochemical events that result in the transport of molecules from one physiological space to another.
MCID: MC01393691
PMOID: PMO:00014877
Subclass_of: Regulatory Pathway
Tree Number: T4.8.59
database_cross_reference: NCI:C91760

ABC Transporter Pathway
type: Class
subclass of: Transport Pathway
Definition: The ATP-binding cassette (ABC) transporters form one of the largest known protein families and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
MCID: MC01393828
PMOID: PMO:00014878
Subclass_of: Transport Pathway
Synonym: ABC transporters
Synonym: ATP-Binding Cassette Transporter Pathway
Tree Number: T4.8.59.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91509
database_cross_reference: NCI_KEGG:C91509

Bacterial Secretion System Pathway
type: Class
subclass of: Transport Pathway
Definition: Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
MCID: MC01393813
PMOID: PMO:00014879
Subclass_of: Transport Pathway
Synonym: Bacterial secretion system
Synonym: Type II Secretion System
Synonym: Type III Secretion System
Synonym: Type IV Secretion System
Tree Number: T4.8.59.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38877
database_cross_reference: NCI_KEGG:C38877

Fc Gamma Receptor-Mediated Phagocytosis Pathway
type: Class
subclass of: Transport Pathway
Definition: Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsinization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
MCID: MC01393684
PMOID: PMO:00014880
Subclass_of: Transport Pathway
Synonym: Fc gamma R-mediated phagocytosis
Tree Number: T4.8.59.3
database_cross_reference: NCI:C91499
database_cross_reference: NCI_KEGG:C91499

Multi-Drug Resistance Factor Pathway
type: Class
subclass of: Transport Pathway
Definition: Cancer cells resistant to a diverse set of hydrophobic drugs are known as MDR cells (multidrug-resistant). Large membrane proteins overproduced in MDR cells, belong to a family of transport P-glycoproteins known as ATP-binding cassette transporter proteins (ABC-ATPases). These proteins were initially thought to affect the permeability of cells to drugs, but they were later found to be pumps that remove drugs from cells at the cost of ATP hydrolysis. There are seven major families of ABC(ATP-binding cassette) proteins, two of them are shown on this pathway, MDR/TAP (Multi-Drug Resistance) and MRP (Multi-Drug Resistance Related Proteins). Members of the MDR/TAP subfamily are involved in multi-drug resistance as well as antigen presentation. Additional factors involved in detoxification are the P450 cytochromes (CYPs), glutathione-S-transferase (GST). Lack of MDR3 can cause a form of Progressive Familial Intrahepatic Cholestasis (PFIC), a heterogeneous group of autosomal recessive liver disorders, characterized by early onset of cholestasis that progresses to cirrhosis and liver failure before adulthood. (This definition may be outdated - see the DesignNote.)
MCID: MC01394132
PMOID: PMO:00014881
Subclass_of: Transport Pathway
Synonym: Multi-Drug Resistance Factors
Tree Number: T4.8.59.4
database_cross_reference: NCI:C91308
database_cross_reference: NCI_BioC:C91308

Phagocytosis Pathway
type: Class
subclass of: Transport Pathway
Definition: Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
MCID: MC01393761
PMOID: PMO:00014882
Subclass_of: Transport Pathway
Synonym: Phagosome
Tree Number: T4.8.59.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91809
database_cross_reference: NCI_KEGG:C91809

Protein Cycling Pathway
type: Class
subclass of: Transport Pathway
Definition: A representation of the sequence of biological or biochemical events that occur as a protein is cycled between the plasma membrane and endosomal vesicles.
MCID: MC01394007
PMOID: PMO:00014883
Subclass_of: Transport Pathway
Synonym: Protein Recycling Pathway
Tree Number: T4.8.59.6
database_cross_reference: NCI:C40421

ErbB3 Receptor Recycling Pathway
type: Class
subclass of: Protein Cycling Pathway
Definition: The neuregulins comprise a subfamily of at least four epidermal growth factor (EGF)-like growth factors that influence a variety of cellular events, including proliferation, differentiation, migration, survival, and fate. The most thoroughly examined neuregulin, neu differentiation factor NDF (AKA: neuregulin-1; NRG1; also heregulin, glial growth factor, or acetylcholine receptor-inducing activity), has been shown to play essential roles in the development of cardiac and neural tissues and also has been shown to play a role in the postsynaptic development of the neuromuscular junction. The neuregulins bind to ErbB3 or ErbB4 and can activate the ErbB2 receptor through a heterodimerization mechanism. Heterodimers of ErbB3 and ErbB2, which has no direct ligand, are potent in causing cell transformation. Controlled levels of signaling through ErbB and other growth factor receptors are maintained by keeping a relatively limited amount of receptors at the cell surface. Receptor overexpression can lead to disease states such as the genesis or progression of tumors. Hence, mechanisms must exist for localizing and maintaining a precise concentration of growth factor receptors at the site of signal reception. ErbB2, ErbB3, and ErbB4 are somewhat unique among studied receptor tyrosine kinases in that they exhibit impaired ligand-induced internalization, down-regulation, and degradation. In fact, the rate of degradation is dependent on factors that appear to act independent of ligand binding. Nrdp-1 (Neuregulin receptor degradation protein-1) is one such protein. Ndrp-1 is an E3 ubiquitin ligase that tags ErbB3 for degradation in non-lysosomal compartments. The cycling of ErbB1 is similar to that of EGF receptor and is included for contrast. (This definition may be outdated - see the DesignNote.)
MCID: MC00526384
PMOID: PMO:00014884
Subclass_of: Protein Cycling Pathway
Synonym: Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling
Tree Number: T4.8.59.6.1
database_cross_reference: NCI:C39069
database_cross_reference: NCI_BioC:C39069

GABA Receptor Life Cycle Pathway
type: Class
subclass of: Protein Cycling Pathway
Definition: Gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter that acts at synapses through binding to ligand-gated ion channels, the GABA receptors. Clustering of the GABA-A receptor chloride channel alters receptor pharmacology on the cell surface and reduced clustering of the GABA receptor is associated with anxiety. GABA-A interacts with several proteins that modulate its clustering, endocytosis, and recycling or degradation. Plic-1 is a ubiquitin-like protein that binds to GABA-A receptors and causes them to accumulate at inhibitory synapses. Gephyrin interacts with the cytoplasmic domain of GABA-A, and with microtubules, bringing receptors together in plasma microdomains. Curiously, Gephyrin appears to be a bifunctional protein, with a domain involved in molybdenum metabolism. Another protein interacting with the GABA-A receptor is GABARAP, a microtubule-associated protein. Anchoring of the GABA-A receptor to GABARAP helps to cluster the receptor at the synaptic termini and to mediate fast synaptic transmission. GABARAP may mediate interaction of gephyrin with the GABA-A receptor and gephyrin may stabilize clusters by forming multimeric structures. GABARAP and gephyrin may play more of a role in receptor sorting and transport to the cell surface than in anchoring to the cytoplasm, since at inhibitory synapses GABARAP appears to associate with transport vesicles rather than the cell surface. The association of GABARAP with NSF (N-ethyl maleimide sensitive factor), a protein involved in intracellular vesicle transport, supports this hypothesis. (This definition may be outdated - see the DesignNote.)
MCID: MC00526577
PMOID: PMO:00014885
Subclass_of: Protein Cycling Pathway
Synonym: Gamma-aminobutyric Acid Receptor Life Cycle
Tree Number: T4.8.59.6.2
database_cross_reference: NCI:C39089
database_cross_reference: NCI_BioC:C39089

GPCR Desensitization Pathway
type: Class
subclass of: Protein Cycling Pathway
Definition: Homologous desensitization of GPCRs results from the binding of b-arrestins (b-arr) to agonist -occupied receptors following phosphorylation of the receptor by GRKs. b-arrestin binding sterically precludes coupling between the receptor and heterotrimeric G proteins, leading to termination of signaling by G proteins effectors. Receptor-bound b-arrestins also act as adapter proteins, binding to components of the clathrin endocytic machinery including clathrin, b2-adaptin (AP-2). Receptor sequestration reflects the dynamin (Dyn)-dependent endocytosis of GPCRs via clathrin-coated pits. Once internalized, GPCRs exhibit two distinct patterns of b-arrestin interaction. Class A GPCRs, for example the b2 adrenergic receptor, rapidly dissociate from b-arrestin upon internalization. These receptors are trafficked to an acidified endosomal compartment, wherein the ligand is dissociated and the receptor dephosphorylated by a GPCR-specific protein phosphatase PP2A isoform, and are subsequently recycled to the plasma membrane. Class B receptors, for example the angiotensin II AT1a receptor, form stable receptor-b-arrestin complexes. These receptors accumulate in endocytic vesicles and are either targeted for degradation or slowly recycled to the membrane via as yet poorly defined routes. (This definition may be outdated - see the DesignNote.)
MCID: MC00526589
PMOID: PMO:00014886
Subclass_of: Protein Cycling Pathway
Synonym: beta-arrestins in GPCR Desensitization
Tree Number: T4.8.59.6.3
database_cross_reference: NCI:C39000
database_cross_reference: NCI_BioC:C39000

Ran Cycling Pathway
type: Class
subclass of: Protein Cycling Pathway
Definition: Ran is a member of the Ras family of small GTPases. Ran is an important component of many crucial nucleocytoplasmic transport pathways. The cycling of Ran is controlled by the RanGTP-RanGDP gradient established by the Ran Guanine nucleotide exchange Factor (RanGEF) RCC1 and the Ran GTPase-activating Protein (RanGAP). These two proteins combine to create a Ran gradient where RanGDP is predominantly cytoplasmic. RCC1 binds to chromatin and so RanGTP is found associated with DNA. RCC1 dissociated GDP from Ran and allows GTP to be bound. As Ran leaves the nucleus the two Ran binding proteins, RanBP1 and RanBP2 cooperate with RanGAP to induce GTP hydrolysis of Ran. There are several nuclear import factors that use the Ran gradient as part of their translocation mechanism. (This definition may be outdated - see the DesignNote.)
MCID: MC00525103
PMOID: PMO:00014887
Subclass_of: Protein Cycling Pathway
Synonym: Cycling of Ran in nucleocytoplasmic transport
Tree Number: T4.8.59.6.4
database_cross_reference: NCI:C39214
database_cross_reference: NCI_BioC:C39214

Protein Export Pathway
type: Class
subclass of: Transport Pathway
Definition: Protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
MCID: MC00525018
PMOID: PMO:00014888
Subclass_of: Transport Pathway
Synonym: Protein Export
Tree Number: T4.8.59.7
database_cross_reference: NCI:C38857
database_cross_reference: NCI_KEGG:C38857

Protein Import into Nucleus Pathway
type: Class
subclass of: Transport Pathway
Definition: Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus and cytoplasm. This includes the movement of small molecules and the selective, facilitated transport of large proteins and RNAs. Faithful, continuous NPC assembly is key for maintaining normal physiological function and is closely tied to proper cell division. One of the unexpected developments during the past decade was the realization that the NPC itself probably does not function primarily as a gating mechanism or by directly transporting cargo macromolecules between the nuclear and cytoplasmic compartments. Instead, nuclear trafficking relies on a range of soluble components. Transport factors bind their cargo in one compartment and then move through the NPCs to the other compartment, where the cargo is released. The transport factor then recycles back through the NPC to participate in another round of transport. In many instances, this process is orchestrated by the Ras-superfamily GTPase Ran. Bischoff et al. describe in detail how the nucleotide state of Ran is controlled by its nuclear guanine-nucleotide-exchange factor (RCC1) and cytoplasmic GTPase-activating protein (RanGAP). The nucleotide state of Ran is crucial to defining the interactions between transport factors, their cargoes and nucleoporins, and is fundamental to the sorting mechanism that defines the directionality of transport. (This definition may be outdated - see the DesignNote.)
MCID: MC00525020
PMOID: PMO:00014889
Subclass_of: Transport Pathway
Synonym: Mechanism of Protein Import into the Nucleus
Tree Number: T4.8.59.8
database_cross_reference: NCI:C39171
database_cross_reference: NCI_BioC:C39171

Rab GTPases in Endocytosis Pathway
type: Class
subclass of: Transport Pathway
Definition: The eukaryotic cell contains compartments with distinct functions bounded by lipid bilayer membranes. The movement of membrane vesicles between these compartments allows proteins in the secretory pathway to move outward from the endoplasmic reticulum (ER) to the Golgi, trans Golgi network (TGN), secretory vesicles, and the plasma membrane and to be secreted into the extracellular environment. The trafficking of membrane vesicles is also essential for endocytosis and the movement of material from the extracellular environment into the early endosome (EE), late endosome (LE), and lysosome. The movement of vesicles and their contents between these compartments, and their secretion, are essential for a host of cellular functions, including the release of neurotransmitters and hormones. The movement of membrane vesicles between all of these compartments is regulated by members of the Rab family of GTPases, part of the ras superfamily of genes, regulated through binding of GTP and hydrolysis of bound GTP to GDP. At least eleven yeast genes in this family have been identified as Ypts, yeast transport proteins, and over sixty mammalian Rab genes have been identified in this highly conserved gene family. The products of the Rab genes regulate specific steps in vesicle transport. Rab1 is involved in the movement of membranes from the ER through the Golgi. Rab3 regulates secretory vesicle release and Rab27 is also involved in regulated release of secreted proteins. Rab5, 7 and 9 contribute to endocytosis while Rab4 and Rab11 mediate recycling from the endosome back to the plasma membrane. Rab11 is involved in both endocytosis and exocytosis. As with other Ras family GTPases, the activity of Rabs is regulated by guanine-nucleotide exchange factors (GEFs) and GAPs (GTPase activating proteins). Downstream effectors must also interact with Rabs to transmit their signals regulating each step of the membrane trafficking pathways including vesicle formation, movement of vesicles betw…
MCID: MC00525088
PMOID: PMO:00014890
Subclass_of: Transport Pathway
Synonym: Rab GTPases Mark Targets in the Endocytotic Machinery
Tree Number: T4.8.59.9
database_cross_reference: NCI:C39207
database_cross_reference: NCI_BioC:C39207

SNARE Proteins Vesicular Transport Pathway
type: Class
subclass of: Transport Pathway
MCID: MC01394231
PMOID: PMO:00014891
Subclass_of: Transport Pathway
Synonym: SNARE interactions in vesicular transport
Tree Number: T4.8.59.10
database_cross_reference: NCI:C91429
database_cross_reference: NCI_KEGG:C91429

Synaptic Vesicle Endocytosis Pathway
type: Class
subclass of: Transport Pathway
Definition: Reliable neurotransmitter release requires the presence of sufficient numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) is coordinated by a group of proteins called dephosphins. The current set of seven known dephosphins are nerve terminal proteins with little or no structural homology but satisfy two essential criteria: they are essential for SVE and they are rapidly and coordinately dephosphorylated in response to a calcium influx through voltage-dependent calcium channels. The calcium signal is mediated by calmodulin (CaM) and calcineurin. Each dephosphin plays an essential role in overlapping phases or segments of the cycle. The four phases of SVE are nucleation, invagination, fission and uncoating. The nucleation phase initiates with the activation of CaM/Calcineurin and the subsequent dephosphorylation of AP180. AP180 and clathrin are then recruited to the membrane by AP2 and PtdIns(4,5)P2. Nucleation is completed by the addition of epsin and eps15. Invagination proceeds with the formation of the amphiphysin1/2 heterodimer and its addition to the maturing vesicle surface complexes. The final components, dynamin and synaptojanin, are recruited to the budding vesicle by the amphiphysin1/2 heterodimer. Dynamin forms a complete ring around the vesicle neck and completes fission via its PtdIns(4,5)P2 stimulated GTPase activity. After internalization the vesicle is quickly uncoated, in a process believed to be mediated by synaptojanin, and is accompanied by the disassembly of clathrin. (This definition may be outdated - see the DesignNote.)
MCID: MC00526337
PMOID: PMO:00014892
Subclass_of: Transport Pathway
Synonym: Endocytotic role of NDK, Phosphins and Dynamin
Synonym: SVE Pathway
Tree Number: T4.8.59.11
database_cross_reference: NCI:C39161
database_cross_reference: NCI_BioC:C39161

Vesicle Transport Pathway
type: Class
subclass of: Transport Pathway
Definition: Eukaryotic cells take up constituents of the extra-cellular environment and regulate the cell-surface level of membrane proteins via a recycling system of membrane vesicles called endosomes. When cells are taking up elements from the cell-surface it is called endocytosis, and when they are delivered to the cell-surface it is called exocytosis. The transferrin receptor (TfR) is often employed as a model protein for studying this process. The transferrin receptor mediates uptake of iron by binding diferrictransferrin (Tf-2Fe++) from the plasma. Endocytosis of the receptor is initiated by the formation of a clathrin-coated pit in the cell membrane, which subsequently forms the primary endosome and then fuses with the early endosome. The lumen of an early endosome has a slightly acidic pH, which enables the ions to be released. The ions move to the cytosol and the receptor-apotransferrin (Tf) complex is sorted for recycling back to the cell membrane in recycling endosomes. At the cell surface the apotransferrin is replaced with diferrictransferrin and the cycle repeats. Whether an endocytosed protein is recycled or not is determined by a sorting process initiated in the early endosome. The early endosome is the first organelle along the endo-lysosomal pathway and it is the major sorting station. Internalized membrane proteins can either be sorted for recycling from the early endosome by a fast route (e.g., TfR) or make it to the late endosome and recycle by a slow route (e.g., angiotensin receptor, AT1R) or be retained in the late endosome and directed to the lysosome for degradation (e.g., epidermal growth factor receptor, EGFR). The early endosome has been suggested to turn into a multi-vesicular late endosome through a maturation process that changes its biochemical composition and morphology. The late endosome is followed by the lysosome, which is the terminal organelle on the endocytic pathway and is devoid of recycling receptors. The lysosome has a very acidic env…
MCID: MC00527912
PMOID: PMO:00014893
Subclass_of: Transport Pathway
Synonym: The role of FYVE-finger proteins in vesicle transport
Tree Number: T4.8.59.12
database_cross_reference: NCI:C39056
database_cross_reference: NCI_BioC:C39056

Signaling Pathway
type: Class
subclass of: Biochemical Pathway
Definition: An elaboration of the known or inferred interactions involved in a signal transduction pathway.
MCID: MC00011850
PMOID: PMO:00014894
Subclass_of: Biochemical Pathway
Synonym: Pathway, Signal
Synonym: Pathways, Signal
Synonym: Signal Pathway
Synonym: Signal Pathways
Synonym: pathway signaling
Synonym: pathways signaling
Synonym: signal pathway
Tree Number: T4.9
database_cross_reference: CHV:0000011337
database_cross_reference: MSH:D015398

Adherens Junction Assembly Pathway
type: Class
subclass of: Signaling Pathway
Definition: Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
MCID: MC01394292
PMOID: PMO:00014895
Subclass_of: Signaling Pathway
Synonym: Adherens junction
Tree Number: T4.9.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91462
database_cross_reference: NCI_KEGG:C91462

Adipocytokine Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin.
MCID: MC00690425
PMOID: PMO:00014896
Subclass_of: Signaling Pathway
Synonym: Adipocytokine signaling pathway
Synonym: adipocytokine signaling pathway
Tree Number: T4.9.2
database_cross_reference: GO:GO:0033209
database_cross_reference: GO:GO:0033210
database_cross_reference: GO:GO:0033211
database_cross_reference: NCI:C91486
database_cross_reference: NCI_KEGG:C91486

ADP-Ribosylation Pathway
type: Class
subclass of: Signaling Pathway
Definition: ADP-ribosylation factors (ARFs) are 20-kDa guanine nucleotide-binding proteins, members of the Ras GTPase superfamily that were initially recognized and purified because of their ability to stimulate the ADP-ribosyltransferase activity of the cholera toxin A subunit. We now know that they are critical components of several different vesicular trafficking pathways in all eukaryotic cells and activators of specific phospholipase Ds (PLDs). ARF interacts with many proteins and other molecules that regulate its state of activation or are involved in its intracellular function. Arf proteins cycle between GDP-bound, inactive and GTP-bound, active forms, and the cycling is regulated by specific GEPs and GAPs. Members of the Arf GEP family can be grouped into two major subfamilies on the basis of their sequence similarities and functional differences. The high-molecular-weight Arf GEP subfamily includes yeast Sec7, Gea1, and Gea2, and mammalian BIG1/p200, BIG2, and GBF1, which all consist of 1,400-2,000 amino acid residues. Many Arf GAPs are multidomain proteins and have been found to interact with multiple signaling molecules. For instance, ASAP1 has a PH domain, ankyrin (ANK) repeats, proline-rich and Src-homology (SH) 3 domains and has been shown to bind PI, P2, Src, and Crk. PAPa/PAG3, with a similar domain structure, binds phosphoinositides, Src, Pyk, and paxillin. The GITs bind bARK, paxillin and the Rac/Cdc42 exchange factor PIX (also known as Cool). ASAP-related proteins, ARAP1, 2 and 3 have Arf GAP, Rho GAP, Ankyrin repeat, Ras-associating (RA), and five PH domains, and therefore have the potential of integrating four signaling pathways. (This definition may be outdated - see the DesignNote.)
MCID: MC01393939
PMOID: PMO:00014897
Subclass_of: Signaling Pathway
Synonym: ADP-Ribosylation Factor
Tree Number: T4.9.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38989
database_cross_reference: NCI_BioC:C38989

AHR Signal Transduction Pathway
type: Class
subclass of: Signaling Pathway
Definition: The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus and heterodimerizes with the transcription factor ARNT. The Ah receptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and NAD(P)H quinone oxidoreductase. The inactive form of the Ah receptor exists in the cytoplasm as a tetrameric complex composed of the ligand binding subunit, a dimer of the 90-kDa heat shock protein, and X-associated protein 2 (also referred to as AIP or ARA9). (This definition may be outdated - see the DesignNote.)
MCID: MC00522966
PMOID: PMO:00014898
Subclass_of: Signaling Pathway
Synonym: Ahr Signal Transduction Pathway
Tree Number: T4.9.4
database_cross_reference: NCI:C38972
database_cross_reference: NCI_BioC:C38972

AKT Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activate the kinase PDK1, 3-phosphoinositide-dependent protein kinase-1, which in turn activates the kinase AKT, also known as protein kinase B. Proteins phosphorylated by activated AKT promote cell survival. Phosphorylation of Ikappa-B kinase leads to activation of the transcription factor NF-kB to oppose apoptosis. Bad is a protein in the Bcl-2 gene family that opposes Bcl-2 to induce apoptosis. Phosphorylation of Bad by AKT blocks anti-apoptotic activity to promote cell survival. Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors. AKT promotes cell survival and opposes apoptosis by a variety of routes. (This definition may be outdated - see the DesignNote.)
MCID: MC00525861
PMOID: PMO:00014899
Subclass_of: Signaling Pathway
Tree Number: T4.9.5
database_cross_reference: NCI:C38981
database_cross_reference: NCI_BioC:C38981

Alpha-Synuclein Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393794
PMOID: PMO:00014900
Subclass_of: Signaling Pathway
Synonym: Alpha-synuclein signaling
Tree Number: T4.9.6
database_cross_reference: NCI:C91535
database_cross_reference: NCI_PID:C91535

Alternative NF-kappaB Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393796
PMOID: PMO:00014901
Subclass_of: Signaling Pathway
Synonym: Alternative NF-kappaB pathway
Tree Number: T4.9.7
database_cross_reference: NCI:C91536
database_cross_reference: NCI_PID:C91536

Androgen-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393801
PMOID: PMO:00014902
Subclass_of: Signaling Pathway
Synonym: Androgen-mediated signaling
Tree Number: T4.9.8
database_cross_reference: NCI:C91538
database_cross_reference: NCI_PID:C91538

Androgen Receptor Regulation Pathway
type: Class
subclass of: Androgen-Mediated Signaling Pathway
MCID: MC00815383
PMOID: PMO:00014903
Subclass_of: Androgen-Mediated Signaling Pathway
Synonym: Regulation of Androgen receptor activity
Synonym: regulation of androgen receptor activity
Tree Number: T4.9.8.1
database_cross_reference: GO:GO:2000823
database_cross_reference: NCI:C91659
database_cross_reference: NCI_PID:C91659

Coregulation Pathway for Androgen Receptor Activity
type: Class
subclass of: Androgen-Mediated Signaling Pathway
MCID: MC01394125
PMOID: PMO:00014904
Subclass_of: Androgen-Mediated Signaling Pathway
Synonym: Coregulation of Androgen receptor activity
Tree Number: T4.9.8.2
database_cross_reference: NCI:C91568
database_cross_reference: NCI_PID:C91568

Nongenotropic Androgen Signaling Pathway
type: Class
subclass of: Androgen-Mediated Signaling Pathway
MCID: MC01393871
PMOID: PMO:00014905
Subclass_of: Androgen-Mediated Signaling Pathway
Synonym: Nongenotropic Androgen signaling
Tree Number: T4.9.8.3
database_cross_reference: NCI:C91640
database_cross_reference: NCI_PID:C91640

Angiopoietin-1 Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393803
PMOID: PMO:00014906
Subclass_of: Signaling Pathway
Synonym: Angiopoietin receptor Tie2-mediated signaling
Synonym: TEK Signaling Pathway
Tree Number: T4.9.9
database_cross_reference: NCI:C91539
database_cross_reference: NCI_PID:C91539

Angiotensin II Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Ang II binding to AT1-R triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and to the small G protein Rac1 but not Cdc42. In turn, Rac1 activates a small G protein-activated kinase whose identity is still controversial, but which has been suggested to be PAK1. Finally, the JNK cascade, including MEKK1, SEK1, and JNK, is activated, causing induction of the c-Jun gene via binding of ATF2 and c-Jun heterodimer to the junTRE2 site. Ang II is closely involved in cardiac remodeling by stimulating synthesis of extracellular matrix proteins. It was recently found that expression of fibronectin by Ang II is transcriptionally regulated by AP-1 complex in cardiac fibroblasts. The collagenase gene, containing AP-1 sites, is also regulated by AP-1 components, including c-Jun. AP-1 activity is also enhanced in Ang II-induced cardiac hypertrophy. Expression of ANF is regulated by AP-1 components. (This definition may be outdated - see the DesignNote.)
MCID: MC00523074
PMOID: PMO:00014907
Subclass_of: Signaling Pathway
Synonym: Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
Tree Number: T4.9.10
database_cross_reference: NCI:C38995
database_cross_reference: NCI_BioC:C38995

Arf1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393805
PMOID: PMO:00014908
Subclass_of: Signaling Pathway
Synonym: Arf1 pathway
Tree Number: T4.9.11
database_cross_reference: NCI:C91540
database_cross_reference: NCI_PID:C91540

Arf6 Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393808
PMOID: PMO:00014909
Subclass_of: Signaling Pathway
Synonym: Arf6 signaling events
Tree Number: T4.9.12
database_cross_reference: NCI:C91541
database_cross_reference: NCI_PID:C91541

Arf6 Signaling Pathway
type: Class
subclass of: Arf6 Pathway
MCID: MC01393781
PMOID: PMO:00014910
Subclass_of: Arf6 Pathway
Synonym: Arf6 downstream pathway
Tree Number: T4.9.12.1
database_cross_reference: NCI:C91542
database_cross_reference: NCI_PID:C91542

Arf6 Trafficking Pathway
type: Class
subclass of: Arf6 Pathway
MCID: MC01393783
PMOID: PMO:00014911
Subclass_of: Arf6 Pathway
Synonym: Arf6 trafficking events
Tree Number: T4.9.12.2
database_cross_reference: NCI:C91543
database_cross_reference: NCI_PID:C91543

ATM Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells. (This definition may be outdated - see the DesignNote.)
MCID: MC00522972
PMOID: PMO:00014912
Subclass_of: Signaling Pathway
Tree Number: T4.9.13
database_cross_reference: NCI:C38996
database_cross_reference: NCI_BioC:C38996

Attenuation of GPCR Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The G-protein coupled receptor (GPCR) family transduces extracellular signals across the plasma membrane, activating cellular responses through a variety of second messenger cascades (see PKA and PKC signaling pathways). These receptors provide rapid responses to a variety of stimuli, and are often rapidly attenuated in their signaling. Failure to attenuate GPCR signaling can have dramatic consequences. One method to attenuate GPCR signaling is by removal of the stimulus from the extracellular fluid. At the synapse, removal of neurotransmitter or peptide signaling molecules is accomplished by either reuptake or degradation. Acetylcholine is removed from synapses through degradation by the enzyme acetylcholinesterase. Inhibition of acetylcholinesterase results in prolonged signaling at the neuromuscular junction, and uncontrollable spasms in humans caused by nerve gas or in insects by some insecticides. Inhibition of acetylcholinesterase is also used therapeutically to treat Alzheimer's disease, compensating for the loss of cholinergic neurons. Transporters for serotonin, dopamine, GABA and noradrenaline remove these neurotransmitters from the synapse to terminate signaling. Antidepressants such as Prozac inhibit reuptake of serotonin and many drugs of abuse such as cocaine act by blocking reuptake of dopamine or adrenaline. Reuptake not only terminates signaling, but can also conserve neurotransmitter through recycling back into the presynaptic cell. The next step in the attenuation of GPCR signaling is receptor desensitization, in which receptors are modified to no longer transduce a signal even if the stimulus is still present. Desensitization of GPCRs occurs through protein kinases that phosphorylate the GPCR to turn off signaling. Downstream protein kinases such as PKA and PKC turned on by GPCR signaling can phosphorylate the activated GPCR and other GPCRs to prevent further signaling. G-protein receptor kinases (GRKs) are a family of kinases that specifically p…
MCID: MC00526012
PMOID: PMO:00014913
Subclass_of: Signaling Pathway
Synonym: Attenuation of GPCR Signaling
Tree Number: T4.9.14
database_cross_reference: NCI:C38974
database_cross_reference: NCI_BioC:C38974

Atypical NF-kappaB Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394179
PMOID: PMO:00014914
Subclass_of: Signaling Pathway
Synonym: Atypical NF-kappaB pathway
Tree Number: T4.9.15
database_cross_reference: NCI:C91545
database_cross_reference: NCI_PID:C91545

BCR Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Significant progress has been made towards delineation of the intrinsic molecular processes that regulate B lymphocyte immune function. Recent observations have provided a clearer picture of the interactive signaling pathways that emanate from the mature B cell antigen receptor (BCR) complex and the different precursor complexes that are expressed during development. Studies have also revealed that the net functional response to a given antigenic challenge is affected by the combined action of BCR-dependent signaling pathways, as well as those originating from various coreceptors expressed by B cells (e.g. CD19, CD22, FcgRIIb and PIR-B).It is now well established that reversible tyrosine phosphorylation plays an important role in regulating B cell biology. In particular, binding of antigen to the BCR promotes the activation of several protein tyrosine kinases (PTK) that, in conjunction with protein tyrosine phosphatases (PTP), alter the homeostasis of reversible tyrosine phosphorylation in the resting B cell. The net effect is a transient increase in protein tyrosine phosphorylation that facilitates the phosphotyrosine dependent formation of effector protein complexes, promotes targeting of effector proteins to specific microenvironments within the B cell and initiates the catalytic activation of downstream effector proteins. Studies have demonstrated that Src family PTKs are activated initially and serve to phosphorylate CD79a and CD79b thereby creating phosphotyrosine motifs that recruit downstream signaling proteins. In particular, phosphorylation of the BCR complex leads to the recruitment and activation of the PTK Syk, which in turn promotes phosphorylation of PLCg, Shc and Vav. Additionally, the Tec family member Btk is recruited to the plasma membrane where it is involved in activation of PLCg. Initiation of B lymphocyte activation is dependent on the tyrosine phosphorylation-dependent formation of multi-molecular effector protein complexes that activate down…
PMOID: PMO:00014915
Subclass_of: Signaling Pathway
Tree Number: T4.9.16

Beta-Catenin Accumulation Pathway
type: Class
subclass of: Signaling Pathway
Definition: Lipopolysaccharide (LPS) from XX bacteria induces a wide range of inflammatory responses, including the response of alveolar macrophages to bacteria in the lungs. CD14 and the Toll-like receptor TLR4 are activated by LPS, initiating a signaling cascade that activates PI3 kinase and increases synthesis of the inositol phosphate PIP3. PIP3 activates the inositol phosphate dependent protein kinase PDK1, which activates AKT (protein kinase B). One of the key actions of AKT is to block apoptosis. AKT phosphorylation of NF-kB promotes the survival and activation of macrophages responding to LPS. Another substrate of AKT is the protein kinase Gsk3-beta. AKT phosphorylates and deactivates Gsk3-beta. Non-phosphorylated Gsk3-beta is active and phosphorylates beta-catenin, leading to its degradation in the ubiquitin dependent proteasome pathway. Stimulation by LPS causes the accumulation of beta-catenin in the nucleus and the activation of genes in concert with the transcription factor LEF1. This pathway is probably not restricted to alveolar pathway, but leads to the activation of beta-catenin dependent genes by LPS in other cells as well. Other pathways regulate this pathway also, such as the modulation of PI3 kinase activity by ceramide and the inhibition of Gsk3-beta activity by the Wnt/frizzled/disheveled (DSH) pathway. (This definition may be outdated - see the DesignNote.)
MCID: MC00523206
PMOID: PMO:00014916
Subclass_of: Signaling Pathway
Synonym: Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
Tree Number: T4.9.17
database_cross_reference: NCI:C39098
database_cross_reference: NCI_BioC:C39098

Bioactive Peptide Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pressure regulating peptide angiotensin. While these three proteins are distinct in their sequence and physiology, and act through different cell surface receptors, they share in a common class of cell surface receptors called G-protein coupled receptors (GPCRs). Other polypeptide ligands of GPCRs include vasopressin, oxytocin, somatostatin, neuropeptide Y, GnRH, luteinizing hormone, follicle stimulating hormone, parathyroid hormone, orexins, urotensin II, endorphins, enkephalins, and many others. GPCRs form a broad and diverse gene family that responds not only to peptide ligands but also small molecule neurotransmitters (acetylcholine, dopamine, serotonin and adrenaline), light, odorants, taste, lipids, nucleotides, and ions. The main signaling mechanism used by GPCRs is to interact with G-protein GTPase proteins coupled to downstream second messenger systems including intracellular calcium release and cAMP production. The intracellular signaling systems used by peptide GPCRs are similar to those used by all GPCRs, and are typically classified according to the G-protein they interact with and the second messenger system that is activated. For Gs-coupled GPCRs, activation of the G-protein Gs by receptor stimulates the downstream activation of adenylate cyclase and the production of cyclic AMP, while Gi-coupled receptors inhibit cAMP production. One of the key results of cAMP production is activation of protein kinase A. Gq-coupled receptors stimulate phospholipase C, releasing IP3 and diacylglycerol. IP3 binds to a receptor in the ER to cause the release of intracellular calcium, and the subsequent activation of protein kinase C, calmodulin-dependent pathways. In addition to these second messenger signaling systems for GPCRs, GPCR pathways exhibit crosstalk with other signaling pathways including tyrosine kinase growth fa…
MCID: MC00523213
PMOID: PMO:00014917
Subclass_of: Signaling Pathway
Synonym: Bioactive Peptide Induced Signaling Pathway
Tree Number: T4.9.18
database_cross_reference: NCI:C39006
database_cross_reference: NCI_BioC:C39006

BMP Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00388913
PMOID: PMO:00014918
Subclass_of: Signaling Pathway
Synonym: BMP receptor signaling
Synonym: BMP receptor signaling pathway
Synonym: BMP signaling pathway
Synonym: BMP signalling pathway
Synonym: Bone Morphogenic Protein Receptor Family Signaling Pathway
Synonym: bone morphogenetic protein signaling pathway
Synonym: bone morphogenetic protein signalling pathway
Tree Number: T4.9.19
database_cross_reference: GO:GO:0030509
database_cross_reference: NCI:C91552
database_cross_reference: NCI_PID:C91552

Calcium-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
MCID: MC01394327
PMOID: PMO:00014919
Subclass_of: Signaling Pathway
Synonym: Calcium signaling pathway
Tree Number: T4.9.20
database_cross_reference: NCI:C91460
database_cross_reference: NCI_KEGG:C91460

Canonical NF-kappaB Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394223
PMOID: PMO:00014920
Subclass_of: Signaling Pathway
Synonym: Canonical NF-kappaB pathway
Tree Number: T4.9.21
database_cross_reference: NCI:C91558
database_cross_reference: NCI_PID:C91558

CCR3 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response in inflammation is absent in mice lacking CCR3, indicating the key role of this G protein coupled receptor in inflammation and allergic responses. Eotaxin is a chemokine ligand for CCR3 that recruits eosinophils to the site of inflammation and activates them. Other chemokine ligands of CCR3 include eotaxin-2, MCP-3, MCP-4, and RANTES. Multiple signaling pathways activated by CCR3 participate in the inflammatory response of eosinophils. Eotaxin stimulates intracellular calcium release, production of reactive oxygen species, and changes in actin polymerization through a pertussis sensitive pathway. Rho is a G protein that activates ROCK, a protein kinase. Rho and ROCK regulate actin stress fiber formation and are required for eosinophil chemotaxis. Map kinase pathways are also involved in chemotaxis. Another key action of activated eosinophils is the release of reactive oxygen species, causing tissue damage during chronic inflammatory responses. Blocking eosinophil activation and the signaling pathways that lead to chemotaxis, degranulation, and reactive oxygen release may alleviate inflammatory conditions and inflammation-associated tissue damage. (This definition may be outdated - see the DesignNote.)
MCID: MC00523356
PMOID: PMO:00014921
Subclass_of: Signaling Pathway
Synonym: CCR3 signaling in Eosinophils
Tree Number: T4.9.22
database_cross_reference: NCI:C39017
database_cross_reference: NCI_BioC:C39017

CCR5 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection. One mechanism of signaling by these GPCRs is through activation of Gi signaling. These chemokine receptors can also signal through a Gi-independent pertussis toxin-insensitive pathway. This pathway elevates calcium influx into the cell through CRAC channels, ion channels that are activated by calcium release. Elevated calcium from CRAC is required for downstream activation of Pyk2, a focal adhesion-associated protein kinase. Non Gi signaling by these chemokine receptors also involves the Jnk and p38 Map kinase pathways leading to AP-1 activation and activation of genes such as MIP-1 and MCP-1. This pathway may be involved in the role of macrophages in the pathogenesis of AIDS. (This definition may be outdated - see the DesignNote.)
MCID: MC00523357
PMOID: PMO:00014922
Subclass_of: Signaling Pathway
Synonym: Pertussis toxin-insensitive CCR5 Signaling in Macrophage
Tree Number: T4.9.23
database_cross_reference: NCI:C39018
database_cross_reference: NCI_BioC:C39018

CD40/CD40L Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394230
PMOID: PMO:00014923
Subclass_of: Signaling Pathway
Synonym: CD40/CD40L signaling
Tree Number: T4.9.24
database_cross_reference: NCI:C91561
database_cross_reference: NCI_PID:C91561

CD40L Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The CD40 receptor was first associated with expression in B cells and the role it plays through its ligand CD40L (CD154) in moderating T cell activation. Broader expression may indicate a broader role for CD40 and CD40L in immune function and disease states such as transplant rejection and HIV infection. Disruption and modulation of CD40 interaction with CD40L may prove therapeutic in the treatment of autoimmune disorders, heart disease, and cancer. As a member of the TNF receptor family, CD40 relies on interaction with TRAF proteins to mediate an intracellular signal in response to CD40L binding. The pathway downstream of TRAFs activates the transcription factor NF-kappaB through a kinase pathway involving map kinases, NIK (NF-kappaB inducing kinase) and I-kappa B kinases. Some CD40 responses like regulation of immunoglobulin expression might be mediated by NF-kappaB transcriptional activation. (This definition may be outdated - see the DesignNote.)
MCID: MC00523361
PMOID: PMO:00014924
Subclass_of: Signaling Pathway
Tree Number: T4.9.25
database_cross_reference: NCI:C39019
database_cross_reference: NCI_BioC:C39019

Cell Adhesion Molecule Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell-cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
MCID: MC01394287
PMOID: PMO:00014925
Subclass_of: Signaling Pathway
Synonym: CAM Signaling Pathway
Synonym: Cell adhesion molecules (CAMs)
Tree Number: T4.9.26
database_cross_reference: NCI:C91461
database_cross_reference: NCI_KEGG:C91461

Cell to Cell Adhesion Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Interactions between cells, responsible for cell to cell adhesion, can communicate signals into the cellular interior. These signals often involve interactions with cytoskeletal elements to produce changes in cell motility, migration, proliferation and shape. The cadherins are cell surface adhesion molecules that help form tight junctions between cells, such as in formation of epithelial cell layers. E-cadherin inactivation has been implicated in cancer development. In addition to mediating adhesion with other cells, cadherins transduce signals into cells through interactions with the catenins. Catenins probably affect actin cytoskeletal function through interactions with proteins such as actinin and vinculin. Catenins also probably trigger changes in cell shape and motility by signals through the Rho small GTPases. Another important cell adhesion molecule is CD-31, or PECAM-1, involved in the formation of junctions between endothelial cells, cell migration, migration of lymphocytes, and regulation of lymphocyte activation. Src phosphorylates PECAM-1 on tyrosine residues causing SHP-2 association with PECAM-1. Paxillin acts as an adaptor protein between proteins involved in adhesion signaling like FAK and src and cytoskeletal elements. In addition to signals created by adhesion molecules to alter cellular responses, other signaling pathways can alter adhesion through components of the focal adhesion complex. (This definition may be outdated - see the DesignNote.)
MCID: MC00526126
PMOID: PMO:00014926
Subclass_of: Signaling Pathway
Synonym: Cell to Cell Adhesion Signaling
Tree Number: T4.9.27
database_cross_reference: NCI:C39024
database_cross_reference: NCI_BioC:C39024

Ceramide Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
Definition: Ceramide is a sphingosine-based lipid-signaling molecule involved in the regulation of cellular differentiation, proliferation, and apoptosis. This diagram represents some of the current understanding of the cascades that couple ceramide to specific signaling pathways. These cascades illustrate that ceramide can be a growth stimulus or proapoptotic signal. The ultimate ceramide action is determined within the context of other stimuli and by the subcellular topology of its production and is cell-type specific. There are 2 forms of sphingomyelinase, acid (acid-sphingomyelinase, A-SMase) and neutral (neutral-sphingomyelinase, N-SMase), that can produce ceramide. TNF-alpha can stimulate either form of sphingomyelinase as can other death receptors. Different domains of TNF-alpha stimulate the different SMases. N-SMase stimulation is enhanced by the receptor for activated-C kinase 1 (RACK1). The activity of each form is dependent on the local intracellular pH. In the illustration the forms are separated to reduce confusion however ceramide produced by either method can stimulate either cascade depending on the presence of specific co-factors and activators. A-SMase has been recognized as one of the required molecules to mediate proapoptotic signaling in cell death induced by a diverse array of stresses such as H2O2, Heat, UV exposure and Radiation. ROS generation in mitochondria activates caspase-3 via cooperation of cytochrome c, Aif and caspase-9 and stimulates or increases ceramide generation through A-SMase in a proapoptotic activation cycle. Caspase-3 further increases its own activation by proteolytically cleaving ceramide inhibited catalase which is an inhibitor of ROS generation. Ceramide-activated protein kinase(CARK) also known as Kinase Suppressor of RAS (KSR) activity is in some cases the switch point in the balance between proapoptotic and antiapoptotic signals and is also cell-type specific. In endothelial cells for example the activation of KSR is required …
MCID: MC00526140
PMOID: PMO:00014927
Subclass_of: Signaling Pathway
Synonym: Ceramide Signaling Pathway
Tree Number: T4.9.28
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39026
database_cross_reference: NCI_BioC:C39026

Ceramide Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
MCID: MC00815373
PMOID: PMO:00014928
Subclass_of: Signaling Pathway
Synonym: Ceramide signaling pathway
Synonym: ceramide signaling pathway
Tree Number: T4.9.29
database_cross_reference: GO:GO:0090520
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91563
database_cross_reference: NCI_PID:C91563

Class I PI3K Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394246
PMOID: PMO:00014929
Subclass_of: Signaling Pathway
Synonym: Class I PI3K signaling events
Tree Number: T4.9.30
database_cross_reference: NCI:C91565
database_cross_reference: NCI_PID:C91565

PI3K/AKT1 Signaling Pathway
type: Class
subclass of: Class I PI3K Signaling Pathway
MCID: MC01394215
PMOID: PMO:00014930
Subclass_of: Class I PI3K Signaling Pathway
Synonym: Class I PI3K signaling events mediated by Akt
Tree Number: T4.9.30.1
database_cross_reference: NCI:C91566
database_cross_reference: NCI_PID:C91566

PI3K/Non-Lipid Kinase Signaling Pathway
type: Class
subclass of: Class I PI3K Signaling Pathway
MCID: MC01394122
PMOID: PMO:00014931
Subclass_of: Class I PI3K Signaling Pathway
Synonym: Class IB PI3K non-lipid kinase events
Tree Number: T4.9.30.2
database_cross_reference: NCI:C91567
database_cross_reference: NCI_PID:C91567

Cone Cell Visual Signal Transduction Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394105
PMOID: PMO:00014932
Subclass_of: Signaling Pathway
Synonym: Visual signal transduction: Cones
Tree Number: T4.9.31
database_cross_reference: NCI:C91698
database_cross_reference: NCI_PID:C91698

CREB Activation Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinases CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Growth and neurotrophic factors also stimulate CREB phosphorylation at Ser133. Phosphorylation occurs at Ser133 via p44/42 MAP Kinase and p90RSK and also via p38 MAP Kinase and MSK1. CREB mutants exhibit deficiencies in spatial learning tasks, while flies overexpressing or lacking CREB show enhanced or diminished learning, respectively. (This definition may be outdated - see the DesignNote.)
MCID: MC00523379
PMOID: PMO:00014933
Subclass_of: Signaling Pathway
Synonym: Transcription factor CREB and its extracellular signals
Tree Number: T4.9.32
database_cross_reference: NCI:C39036
database_cross_reference: NCI_BioC:C39036

CXCR3-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394089
PMOID: PMO:00014934
Subclass_of: Signaling Pathway
Synonym: CXCR3-mediated signaling events
Tree Number: T4.9.33
database_cross_reference: NCI:C91569
database_cross_reference: NCI_PID:C91569

CXCR4 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: CXCR4 is a chemokine receptor in the GPCR gene family, and is expressed by cells in the immune system and the central nervous system. In response to binding its ligand SDF-1 (stromal cell-derived factor-1), CXCR4 triggers the migration and recruitment of immune cells. This ligand-receptor pair may also play a role in development of the nervous system. In addition to acting as a chemokine receptor, CXCR4 is a co-receptor for entry of HIV into T cells and ligands of CXCR4, including SDF-1, may help to block HIV infection. Early in the infection of an individual, HIV viruses often are tropic for the CCR5 coreceptor that provides for macrophage entry, then later in infection are tropic for CXCR4 and T cell entry. Viruses that are tropic for CXCR4 are generally syncytium forming, causing T cells to aggregate and be destroyed at a rapid rate. CXCR4 induces downstream signaling by several different pathways. As a GPCR, CXCR4 binding of SDF-1 activates G-protein mediated signaling, including downstream pathways such as ras, and PI3 kinase. PI3 kinase activated by SDF-1 and CXCR4 plays a role in lymphocyte chemotaxis in response to these signals. One endpoint of CXCR4 signaling is the activation of transcription factors such as AP-1 and chemokine regulated genes. JAK/STAT signaling pathways also appear to play a role in SDF-1/CXCR4 signaling. Delineation of the signaling mechanisms utilized by CXCR4 may assist in determining the role of CXCR4 in HIV infection and in the immune response. (This definition may be outdated - see the DesignNote.)
MCID: MC00523385
PMOID: PMO:00014935
Subclass_of: Signaling Pathway
Synonym: C-X-C chemokine receptor CXCR4 signaling pathway
Synonym: CXCR4 signaling pathway
Tree Number: T4.9.34
database_cross_reference: GO:GO:0038159
database_cross_reference: NCI:C39043
database_cross_reference: NCI_BioC:C39043

CXCR4-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394092
PMOID: PMO:00014936
Subclass_of: Signaling Pathway
Synonym: CXCR4-mediated signaling events
Tree Number: T4.9.35
database_cross_reference: NCI:C91570
database_cross_reference: NCI_PID:C91570

Cytokine-Cytokine Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
MCID: MC01394358
PMOID: PMO:00014937
Subclass_of: Signaling Pathway
Synonym: Cytokine-cytokine receptor interaction
Tree Number: T4.9.36
database_cross_reference: NCI:C91469
database_cross_reference: NCI_KEGG:C91469

Cytosolic DNA-Sensing Pathway
type: Class
subclass of: Signaling Pathway
Definition: Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-kappa B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.
MCID: MC01393815
PMOID: PMO:00014938
Subclass_of: Signaling Pathway
Synonym: Cytosolic DNA-sensing pathway
Tree Number: T4.9.37
database_cross_reference: NCI:C91504
database_cross_reference: NCI_KEGG:C91504

D4-GDI Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: D4-GDP dissociation inhibitor (D4-GDI) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kDa mature form of D4-GDI to give a 5 kDa and 23 kDa size fragment. The 23 kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms. (This definition may be outdated - see the DesignNote.)
MCID: MC00523486
PMOID: PMO:00014939
Subclass_of: Signaling Pathway
Tree Number: T4.9.38
database_cross_reference: NCI:C39045
database_cross_reference: NCI_BioC:C39045

E-Cadherin Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394108
PMOID: PMO:00014940
Subclass_of: Signaling Pathway
Synonym: E-cadherin signaling events
Tree Number: T4.9.39
database_cross_reference: NCI:C91575
database_cross_reference: NCI_PID:C91575

Adherens Junction Formation Pathway
type: Class
subclass of: E-Cadherin Signaling Pathway
MCID: MC01394162
PMOID: PMO:00014941
Subclass_of: E-Cadherin Signaling Pathway
Synonym: E-cadherin signaling in the nascent adherens junction
Tree Number: T4.9.39.1
database_cross_reference: NCI:C91577
database_cross_reference: NCI_PID:C91577

Adherens Junction Stabilization Pathway
type: Class
subclass of: E-Cadherin Signaling Pathway
MCID: MC01394229
PMOID: PMO:00014942
Subclass_of: E-Cadherin Signaling Pathway
Synonym: Stabilization and expansion of the E-cadherin adherens junction
Tree Number: T4.9.39.2
database_cross_reference: NCI:C91684
database_cross_reference: NCI_PID:C91684

E-Cadherin Signaling Pathway in Keratinocytes
type: Class
subclass of: E-Cadherin Signaling Pathway
MCID: MC01394114
PMOID: PMO:00014943
Subclass_of: E-Cadherin Signaling Pathway
Synonym: E-cadherin signaling in keratinocytes
Tree Number: T4.9.39.3
database_cross_reference: NCI:C91576
database_cross_reference: NCI_PID:C91576

ECM-Receptor Interaction Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
MCID: MC01393879
PMOID: PMO:00014944
Subclass_of: Signaling Pathway
Synonym: ECM-receptor interaction
Tree Number: T4.9.40
database_cross_reference: NCI:C91515
database_cross_reference: NCI_KEGG:C91515

EGF Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor. Inhibitors of the EGF receptor are being pursued as potential cancer therapies and EGF may stimulate wound healing. Mutation of the EGF receptor has been associated with cancer in humans. The proliferative effects of EGF are signaled through several pathways. Binding of EGF results in EGF receptor dimerization, autophosphorylation of the receptor, and tyrosine phosphorylation of other proteins. The EGF receptor activates ras and the MAP kinase pathway, ultimately causing phosphorylation of transcription factors such as c-Fos to create AP-1 and ELK-1 that contribute to proliferation. Activation of STAT-1 and STAT-3 transcription factors by JAK kinases in response to EGF contributes to proliferative signaling. Phosphatidylinositol signaling and calcium release induced by EGF activate protein kinase C, another component of EGF signaling. Crosstalk of EGF signaling with other pathways make the EGF receptor a junction point between signaling systems. (This definition may be outdated - see the DesignNote.)
MCID: MC00523741
PMOID: PMO:00014945
Subclass_of: Signaling Pathway
Tree Number: T4.9.41
database_cross_reference: NCI:C39058
database_cross_reference: NCI_BioC:C39058

Endothelin Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394136
PMOID: PMO:00014946
Subclass_of: Signaling Pathway
Synonym: Endothelins
Tree Number: T4.9.42
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91580
database_cross_reference: NCI_PID:C91580

EGFR-Dependent Endothelin Signaling Pathway
type: Class
subclass of: Endothelin Pathway
MCID: MC01394138
PMOID: PMO:00014947
Subclass_of: Endothelin Pathway
Synonym: EGFR-dependent Endothelin signaling events
Tree Number: T4.9.42.1
database_cross_reference: NCI:C91581
database_cross_reference: NCI_PID:C91581

Ephrin A Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394141
PMOID: PMO:00014948
Subclass_of: Signaling Pathway
Synonym: EPHA Signaling Pathway
Synonym: EphrinA-EPHA pathway
Tree Number: T4.9.43
database_cross_reference: NCI:C91582
database_cross_reference: NCI_PID:C91582

Ephrin A Forward Signaling Pathway
type: Class
subclass of: Ephrin A Signaling Pathway
MCID: MC01394148
PMOID: PMO:00014949
Subclass_of: Ephrin A Signaling Pathway
Synonym: EPHA forward signaling
Tree Number: T4.9.43.1
database_cross_reference: NCI:C91584
database_cross_reference: NCI_PID:C91584

Ephrin A Reverse Signaling Pathway
type: Class
subclass of: Ephrin A Signaling Pathway
MCID: MC01394318
PMOID: PMO:00014950
Subclass_of: Ephrin A Signaling Pathway
Synonym: Ephrin A reverse signaling
Tree Number: T4.9.43.2
database_cross_reference: NCI:C91587
database_cross_reference: NCI_PID:C91587

Ephrin A2 Forward Signaling Pathway
type: Class
subclass of: Ephrin A Signaling Pathway
MCID: MC01394155
PMOID: PMO:00014951
Subclass_of: Ephrin A Signaling Pathway
Synonym: EPHA2 forward signaling
Tree Number: T4.9.43.3
database_cross_reference: NCI:C91585
database_cross_reference: NCI_PID:C91585

Ephrin B Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394146
PMOID: PMO:00014952
Subclass_of: Signaling Pathway
Synonym: EPHB Signaling Pathway
Synonym: EphrinB-EPHB pathway
Tree Number: T4.9.44
database_cross_reference: NCI:C91583
database_cross_reference: NCI_PID:C91583

Ephrin B Forward Signaling Pathway
type: Class
subclass of: Ephrin B Signaling Pathway
MCID: MC01394156
PMOID: PMO:00014953
Subclass_of: Ephrin B Signaling Pathway
Synonym: EPHB forward signaling
Tree Number: T4.9.44.1
database_cross_reference: NCI:C91586
database_cross_reference: NCI_PID:C91586

Ephrin B Reverse Signaling Pathway
type: Class
subclass of: Ephrin B Signaling Pathway
MCID: MC01394321
PMOID: PMO:00014954
Subclass_of: Ephrin B Signaling Pathway
Synonym: Ephrin B reverse signaling
Tree Number: T4.9.44.2
database_cross_reference: NCI:C91588
database_cross_reference: NCI_PID:C91588

Epidermal Growth Factor Receptor Family Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394328
PMOID: PMO:00014955
Subclass_of: Signaling Pathway
Synonym: ErbB receptor signaling network
Tree Number: T4.9.45
database_cross_reference: NCI:C91590
database_cross_reference: NCI_PID:C91590

Epidermal Growth Factor Receptor Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394167
PMOID: PMO:00014956
Subclass_of: Signaling Pathway
Synonym: EGF receptor (ErbB1) signaling pathway
Tree Number: T4.9.46
database_cross_reference: NCI:C91579
database_cross_reference: NCI_PID:C91579

Epidermal Growth Factor Receptor Downstream Signaling Pathway
type: Class
subclass of: Epidermal Growth Factor Receptor Pathway
MCID: MC01394288
PMOID: PMO:00014957
Subclass_of: Epidermal Growth Factor Receptor Pathway
Synonym: ErbB1 downstream signaling
Tree Number: T4.9.46.1
database_cross_reference: NCI:C91591
database_cross_reference: NCI_PID:C91591

Internalization Pathway for Epidermal Growth Factor Receptor
type: Class
subclass of: Epidermal Growth Factor Receptor Pathway
MCID: MC01393835
PMOID: PMO:00014958
Subclass_of: Epidermal Growth Factor Receptor Pathway
Synonym: Internalization of ErbB1
Tree Number: T4.9.46.2
database_cross_reference: NCI:C91628
database_cross_reference: NCI_PID:C91628

EPO Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes for any number of reasons. The signaling mechanism includes multimerization of the receptor upon ligand binding, activation of MAPK cascade, and phosphorylation and activation of Stat5. (This definition may be outdated - see the DesignNote.)
MCID: MC00523745
PMOID: PMO:00014959
Subclass_of: Signaling Pathway
Synonym: EPO signaling pathway
Synonym: Erythropoietin Signaling Pathway
Tree Number: T4.9.47
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39067
database_cross_reference: NCI:C91589
database_cross_reference: NCI_BioC:C39067
database_cross_reference: NCI_PID:C91589

ERBB Family Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family-epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase.
MCID: MC00815371
PMOID: PMO:00014960
Subclass_of: Signaling Pathway
Synonym: EGF receptor family signaling pathway
Synonym: ERBB signaling pathway
Synonym: ERBB signalling pathway
Synonym: ErbB signaling
Synonym: ErbB signaling pathway
Tree Number: T4.9.48
database_cross_reference: GO:GO:0038127
database_cross_reference: NCI:C91514
database_cross_reference: NCI_KEGG:C91514

ERBB2 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with a molecular weight of 185 KDa. Unlike other members of the EGFR family, no ligand for Her2 has been found and it usually associates with members of ERBB1 family to form functional heterodimers. It has been shown that it can form dimers with ERBB (EGFR), ERBB3 and ERBB4 as well as gp130 subunits of IL-6 receptor. In at least some cell types, the association between gp130 and HRBB2 is essential for HRBB2-ERBB3 phosphorylation and subsequent MAP kinase signaling. Although ERBB1 can form homodimers, the signaling for ERBB1 is usually transient and the receptor undergoes internalization after ligand binding and activation. EGFR-HER2 complex increases the signaling capacity of EGFR by increasing the ligand affinity as well as the recycling of the heterodimer. Of all the ERBB heterodimers, ERBB2-ERBB3 heterodimers perhaps elicit the strongest signal. Removing ERBB3 from the cell has a drastic effect on ERBB2 mediated signaling and downstream effectors. The clinical importance of HER2 cannot be overstated. In addition, monoclonal antibody (Herceptin) against this receptor has been shown to be an effective treatment of breast cancer patients who have a high level of HER2 over expression. (This definition may be outdated - see the DesignNote.)
MCID: MC00523747
PMOID: PMO:00014961
Subclass_of: Signaling Pathway
Synonym: ERBB2 signaling pathway
Synonym: ERBB2 signalling pathway
Synonym: HER2 signaling pathway
Synonym: NEU signaling
Synonym: Role of ERBB2 in Signal Transduction and Oncology
Synonym: receptor tyrosine-protein kinase erbB-2 signaling pathway
Tree Number: T4.9.49
database_cross_reference: GO:GO:0038128
database_cross_reference: NCI:C39103
database_cross_reference: NCI_BioC:C39103

ERBB2/ERBB3 Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00815375
PMOID: PMO:00014962
Subclass_of: Signaling Pathway
Synonym: ERBB2-ERBB3 signaling pathway
Synonym: ERBB2-ERBB3 signalling pathway
Synonym: ErbB2/ErbB3 signaling events
Synonym: HER2-HER3 signaling pathway
Tree Number: T4.9.50
database_cross_reference: GO:GO:0038133
database_cross_reference: NCI:C91592
database_cross_reference: NCI_PID:C91592

ERBB4 Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00815376
PMOID: PMO:00014963
Subclass_of: Signaling Pathway
Synonym: ERBB4 signaling pathway
Synonym: ERBB4 signalling pathway
Synonym: ErbB4 signaling events
Synonym: HER4 signaling pathway
Synonym: receptor tyrosine-protein kinase erbB-4 signaling pathway
Tree Number: T4.9.51
database_cross_reference: GO:GO:0038130
database_cross_reference: NCI:C91593
database_cross_reference: NCI_PID:C91593

Erk1/Erk2 MAPK Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kinase. Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, and MEK and by their effects on development. Signal amplification and the potential for crosstalk appear to be important features of this regulatory network. (This definition may be outdated - see the DesignNote.)
MCID: MC01394016
PMOID: PMO:00014964
Subclass_of: Signaling Pathway
Synonym: Erk1/Erk2 Mapk Signaling pathway
Tree Number: T4.9.52
database_cross_reference: NCI:C39072
database_cross_reference: NCI_BioC:C39072

Erythropoietin Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014965
Subclass_of: Signaling Pathway
Tree Number: T4.9.53

Fas Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
Definition: Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligomerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated and then cleave and activate downstream caspases, and a variety of cellular substrates, leading to cell death. Caspases cleave nuclear lamins, causing the nucleus to break down and lose its normal structure. They also cleave DFF, inducing cleavage and degradation of the genome. Other caspase substrates are involved in cytoskeletal structure, cell cycle regulation and signaling pathways. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of Fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of Fas-mediated apoptosis. (This definition may be outdated - see the DesignNote.)
MCID: MC00526463
PMOID: PMO:00014966
Subclass_of: Signaling Pathway
Synonym: FAS signaling pathway ( CD95 )
Tree Number: T4.9.54
database_cross_reference: NCI:C39077
database_cross_reference: NCI_BioC:C39077

FAS Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
MCID: MC01394300
PMOID: PMO:00014967
Subclass_of: Signaling Pathway
Synonym: FAS signaling pathway (CD95)
Tree Number: T4.9.55
database_cross_reference: NCI:C91594
database_cross_reference: NCI_PID:C91594

FGF Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394309
PMOID: PMO:00014968
Subclass_of: Signaling Pathway
Synonym: FGF signaling pathway
Tree Number: T4.9.56
database_cross_reference: NCI:C91596
database_cross_reference: NCI_PID:C91596

Formyl Peptide Receptor 1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Neutrophils respond to bacterial infection by releasing reactive oxygen species that kill bacteria and by expressing chemokines that attract other immune cells to the site of infection. The multisubunit enzyme NADPH oxidase, expressed by neutrophils, produces reactive oxygen species that are rapidly released in what is known as the respiratory burst. Activity of the NADPH oxidase is induced by fMLP receptor ligands, formylated peptides from bacteria. The fMLP receptor is a G-protein coupled receptor, FPR-1, that activates Map kinase pathways and phospholipase C. Phospholipase C activation releases IP3 and calcium, activating protein kinase C and also activating the transcription factor NFAT, which contributes to activation of chemokine genes. One of the components of the NADPH oxidase is p47phox. PKC activation phosphorylates p47phox to activate NADPH oxidase activity. Activation of Map kinase cascades leads to Erk1/Erk2 dependent p47phox phosphorylation as well as activation of the Elk-1 transcription factor and chemokine gene expression. Inhibition of p38 did not affect p47phox phosphorylation, indicating that p38 is not involved in Erk1/2 activation of the NADPH oxidase. Inhibition of p38 did inhibit NADPH oxidase though, indicating that other pathways contribute to activation of this enzyme. (This definition may be outdated - see the DesignNote.)
MCID: MC00526545
PMOID: PMO:00014969
Subclass_of: Signaling Pathway
Synonym: fMLP induced chemokine gene expression in HMC-1 cells
Tree Number: T4.9.57
database_cross_reference: NCI:C39082
database_cross_reference: NCI_BioC:C39082

G-Protein Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behavior; in many cases this includes the regulation of gene transcription. (This definition may be outdated - see the DesignNote.)
MCID: MC00526561
PMOID: PMO:00014970
Subclass_of: Signaling Pathway
Synonym: Signaling Pathway from G-Protein Families
Tree Number: T4.9.58
database_cross_reference: NCI:C39096
database_cross_reference: NCI_BioC:C39096

Gamma-Secretase Mediated ErbB4 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The HER4/erbB4 receptor tyrosine kinase is a member of the EGF1 receptor family. HER4 is a receptor for the neuregulins (NRGs), a family of growth and differentiation factors. HER4 can also bind and be activated by heparin-binding EGF growth factor, betacellulin, and epiregulin, members of the EGF family which, unlike the NRGs, are also ligands for the EGF receptor. HER4 mRNA is expressed in several tissues such as heart, brain, kidney, and skeletal muscle, suggesting that this receptor is involved in the development and maintenance of a variety of organs and cell types. It is likely that the control of expression and function of HER4 is important in normal development as well as in disease. (This definition may be outdated - see the DesignNote.)
MCID: MC00526650
PMOID: PMO:00014971
Subclass_of: Signaling Pathway
Synonym: g-Secretase mediated ErbB4 Signaling Pathway
Tree Number: T4.9.59
database_cross_reference: NCI:C39070
database_cross_reference: NCI_BioC:C39070

Glucocorticoid Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00451140
PMOID: PMO:00014972
Subclass_of: Signaling Pathway
Synonym: Glucocorticoid receptor signaling
Synonym: glucocorticoid receptor signaling pathway
Synonym: glucocorticoid receptor signalling pathway
Tree Number: T4.9.60
database_cross_reference: GO:GO:0042921
database_cross_reference: NCI:C91602
database_cross_reference: NCI_PID:C91602

Glucocorticoid Receptor Regulatory Network
type: Class
subclass of: Glucocorticoid Receptor Signaling Pathway
MCID: MC01393723
PMOID: PMO:00014973
Subclass_of: Glucocorticoid Receptor Signaling Pathway
Synonym: Glucocorticoid receptor regulatory network
Tree Number: T4.9.60.1
database_cross_reference: NCI:C91603
database_cross_reference: NCI_PID:C91603

Rapid Glucocorticoid Signaling Pathway
type: Class
subclass of: Glucocorticoid Receptor Signaling Pathway
MCID: MC01393743
PMOID: PMO:00014974
Subclass_of: Glucocorticoid Receptor Signaling Pathway
Synonym: Rapid glucocorticoid signaling
Tree Number: T4.9.60.2
database_cross_reference: NCI:C91656
database_cross_reference: NCI_PID:C91656

Glypican Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393724
PMOID: PMO:00014975
Subclass_of: Signaling Pathway
Synonym: Glypican pathway
Tree Number: T4.9.61
database_cross_reference: NCI:C91604
database_cross_reference: NCI_PID:C91604

Glypican 1 Signaling Pathway
type: Class
subclass of: Glypican Signaling Pathway
MCID: MC01393726
PMOID: PMO:00014976
Subclass_of: Glypican Signaling Pathway
Synonym: Glypican 1 network
Tree Number: T4.9.61.1
database_cross_reference: NCI:C91605
database_cross_reference: NCI_PID:C91605

Glypican 2 Signaling Pathway
type: Class
subclass of: Glypican Signaling Pathway
MCID: MC01393728
PMOID: PMO:00014977
Subclass_of: Glypican Signaling Pathway
Synonym: Glypican 2 network
Tree Number: T4.9.61.2
database_cross_reference: NCI:C91606
database_cross_reference: NCI_PID:C91606

Glypican 3 Signaling Pathway
type: Class
subclass of: Glypican Signaling Pathway
MCID: MC01393729
PMOID: PMO:00014978
Subclass_of: Glypican Signaling Pathway
Synonym: Glypican 3 network
Tree Number: T4.9.61.3
database_cross_reference: NCI:C91607
database_cross_reference: NCI_PID:C91607

Gonadotropin-Releasing Hormone Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
MCID: MC01394271
PMOID: PMO:00014979
Subclass_of: Signaling Pathway
Synonym: GnRH signaling pathway
Tree Number: T4.9.62
database_cross_reference: NCI:C91480
database_cross_reference: NCI_KEGG:C91480

GPCR Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The binding of b-arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kinases, including c-Src, Hck and c-Fgr (Src-TK), to the receptor-b-arrestin complex. Several signaling events have been reported to involve b-arrestin-dependent Src recruitment. These include the regulation of clathrin-dependent beta2-adrenergic receptor endocytosis by tyrosine phosphorylation of dynamin, Ras-dependent activation of the ERK1/2 MAP kinase cascade and stimulation of cell proliferation by beta2-adrenergic and neurokinin NK1 receptors, and stimulation of chemokine CXCR1 receptor-mediated neutrophil degranulation. (This definition may be outdated - see the DesignNote.)
MCID: MC00526590
PMOID: PMO:00014980
Subclass_of: Signaling Pathway
Synonym: G protein coupled receptor protein signaling pathway
Synonym: G protein coupled receptor protein signalling pathway
Synonym: G-protein coupled receptor protein signal transduction
Synonym: G-protein coupled receptor protein signaling pathway
Synonym: G-protein coupled receptor signaling pathway
Synonym: G-protein coupled receptor signalling pathway
Synonym: G-protein-coupled receptor protein signaling pathway
Synonym: G-protein-coupled receptor protein signalling pathway
Synonym: GPCR signaling pathway
Synonym: GPCR signalling pathway
Tree Number: T4.9.63
database_cross_reference: GO:GO:0007186
database_cross_reference: NCI:C39001
database_cross_reference: NCI_BioC:C39001

Growth Hormone Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signaling can result in dwarfism and decreases in growth hormone levels with age have been suggested to play a role in the reduced function of some physiological systems. Growth hormone signals a response in cells through the growth hormone receptor, a member of the cytokine receptor gene family. Growth hormone causes the receptor to dimerize, activating the JAK2 protein kinase. The activity of JAK2 mediates many of the downstream responses to growth hormone through phosphorylation of STAT transcription factors, MAP kinases, other kinase cascades and molecules involved in metabolism like IRS-1. Factors like SOCS and SHP-1 appear to play a role in the down regulation of signaling by growth hormone and cytokines. (This definition may be outdated - see the DesignNote.)
MCID: MC00523849
PMOID: PMO:00014981
Subclass_of: Signaling Pathway
Tree Number: T4.9.64
database_cross_reference: NCI:C39092
database_cross_reference: NCI_BioC:C39092

HDAC Class I Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394192
PMOID: PMO:00014982
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by HDAC Class I
Tree Number: T4.9.65
database_cross_reference: NCI:C91674
database_cross_reference: NCI_PID:C91674

HDAC Class II Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394196
PMOID: PMO:00014983
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by HDAC Class II
Tree Number: T4.9.66
database_cross_reference: NCI:C91675
database_cross_reference: NCI_PID:C91675

HDAC Class III Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394199
PMOID: PMO:00014984
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by HDAC Class III
Tree Number: T4.9.67
database_cross_reference: NCI:C91676
database_cross_reference: NCI_PID:C91676

Hedgehog Family-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393746
PMOID: PMO:00014985
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by the Hedgehog family
Tree Number: T4.9.68
database_cross_reference: NCI:C91532
database_cross_reference: NCI_PID:C91532

Hedgehog Signaling Events Mediated by Gli Family Proteins
type: Class
subclass of: Hedgehog Family-Mediated Signaling Pathway
MCID: MC01393652
PMOID: PMO:00014986
Subclass_of: Hedgehog Family-Mediated Signaling Pathway
Synonym: Hedgehog signaling events mediated by Gli proteins
Tree Number: T4.9.68.1
database_cross_reference: NCI:C91608
database_cross_reference: NCI_PID:C91608

Hedgehog Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes.
MCID: MC01393892
PMOID: PMO:00014987
Subclass_of: Signaling Pathway
Synonym: Hedgehog signaling pathway
Synonym: hedgehog signaling pathway
Synonym: smoothened signaling pathway
Synonym: smoothened signalling pathway
Tree Number: T4.9.69
database_cross_reference: GO:GO:0007224
database_cross_reference: NCI:C91516
database_cross_reference: NCI_KEGG:C91516

Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
Definition: The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutated forms of the HGF receptor are associated with oncogenesis and metastasis, making the HGF receptor a potential therapeutic target for cancer drugs. Changes in cell motility, cell shape, adhesion, resistance to apoptosis, and anchorage independent growth all contribute to the role of c-Met in cancer. The HGF receptor is a heterodimer with tyrosine kinase activity and associates with a multiprotein complex involved in downstream signal transduction. The HGF receptor can associate with several different signaling systems, including src, Grb2/SOS, PI3 kinase and Gab1. One of the major substrates of the activated HGF receptor tyrosine kinase is the adaptor protein Gab1. Gab1 interacts with Crk and CrkL, two proteins with SH2 and SH3 protein interaction domains that couple to signaling further downstream. The actions of HGF on paxillin, DOCK180, and Rap1, mediated through GAB1 and other members of this complex, alter cell motility. Regulation of Rho, Rac1, and CDC42 pathways in response to HGF all contribute to changes in cellular motility. Another target of the HGF receptor kinase is the focal adhesion kinase, FAK. The activation of FAK induces the formation of focal adhesions, a preliminary step to increased cell motility and tissue invasion by transformed cells, and paxillin phosphorylation may also alter cell adhesion of Met transformed cells. Src and p130cas are required for the role of FAK in HGF induced cellular transformation. HGF also blocks anoikis, the induction of apoptosis through suspension of cells, by acting on Erk and AKT kinases. This activity may contribute to anchorage independent growth of Met transformed cells. Signaling by integrins also plays a key role in the activation of tissue invasive growth by HGF. The alpha6beta4 integrin acts as a cofactor along with Meta to participate in cell growth and pro…
MCID: MC00388938
PMOID: PMO:00014988
Subclass_of: Signaling Pathway
Synonym: HGF receptor signaling pathway
Synonym: HGF receptor signalling pathway
Synonym: Hepatocyte Growth Factor Receptor Signaling Pathway
Synonym: Met signaling pathway
Synonym: Signaling of Hepatocyte Growth Factor Receptor
Synonym: hepatocyte growth factor receptor signaling pathway
Tree Number: T4.9.70
database_cross_reference: GO:GO:0048012
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39152
database_cross_reference: NCI_BioC:C39152

Hepatocyte Growth Factor Receptor Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
MCID: MC00388938
PMOID: PMO:00014989
Subclass_of: Signaling Pathway
Synonym: HGF receptor signaling pathway
Synonym: HGF receptor signalling pathway
Synonym: Hepatocyte Growth Factor Receptor Signaling Pathway
Synonym: Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta
Synonym: Met signaling pathway
Synonym: Signaling of Hepatocyte Growth Factor Receptor
Synonym: hepatocyte growth factor receptor signaling pathway
Tree Number: T4.9.71
database_cross_reference: GO:GO:0048012
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39152
database_cross_reference: NCI_BioC:C39152

HIF-2-Alpha Transcription Factor Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393639
PMOID: PMO:00014990
Subclass_of: Signaling Pathway
Synonym: HIF-2-alpha transcription factor network
Tree Number: T4.9.72
database_cross_reference: NCI:C91611
database_cross_reference: NCI_PID:C91611

IFN Alpha Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Interferon alpha plays a role in viral infections. Signaling takes place through an IFN receptor complex consisting of two alpha chains (type I receptor) complexed with Jak1 and Tyk2. These kinases phosphorylate Stat1 and Stat2 respectively. (This definition may be outdated - see the DesignNote.)
MCID: MC01394322
PMOID: PMO:00014991
Subclass_of: Signaling Pathway
Synonym: IFN alpha signaling pathway
Tree Number: T4.9.73
database_cross_reference: NCI:C39111
database_cross_reference: NCI_BioC:C39111

IFN Gamma Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Interferon gamma is secreted from CD4+ Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. It plays a role in activating lymphocytes to enhance anti-microbial and anti-tumor effects. In addition it plays a role in regulating the proliferation, differentiation, and response of lymphocyte subsets. Signaling takes place through an IFN Receptor complex consisting of two alpha chains (type I receptor) and two beta chains (type 2 receptor). Upon phosphorylation by Jak1, Stat1 (alpha) transduces the signal into transcriptional events. (This definition may be outdated - see the DesignNote.)
MCID: MC01394297
PMOID: PMO:00014992
Subclass_of: Signaling Pathway
Synonym: IFN gamma signaling pathway
Tree Number: T4.9.74
database_cross_reference: NCI:C39112
database_cross_reference: NCI_BioC:C39112

IGF-1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many different cell types and blocks apoptosis. In vivo IGF-1 acts as an intermediate of many growth hormone responses, and may stimulate the growth of some types of cancer. IGF-1 also provides a mitogenic signal to act as a growth factor for many tissue culture cells. One component of IGF-1 mitogenic signaling is association of the receptor tyrosine kinase with Shc, Grb2, and Sos-1 to activate ras and the Map kinase cascade (raf, Mek, Erk). An endpoint of the Map kinase pathway is modification of transcription factor activity, such as activation of ELK transcription factors. Serum response factor (SRF) and AP-1 contribute to mitogenic signaling by many factors. Phosphorylation of IRS-1 and PI3 kinase activation are also involved in IGF-1 signaling, similar to insulin signaling. (This definition may be outdated - see the DesignNote.)
MCID: MC00523996
PMOID: PMO:00014993
Subclass_of: Signaling Pathway
Tree Number: T4.9.75
database_cross_reference: NCI:C39114
database_cross_reference: NCI_BioC:C39114

IGF1 Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393645
PMOID: PMO:00014994
Subclass_of: Signaling Pathway
Synonym: IGF1 pathway
Synonym: Insulin-Like Growth Factor 1 Signaling Pathway
Synonym: Somatomedin C Signaling Pathway
Tree Number: T4.9.76
database_cross_reference: NCI:C91614
database_cross_reference: NCI_PID:C91614

IL1-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393648
PMOID: PMO:00014995
Subclass_of: Signaling Pathway
Synonym: IL1-mediated signaling events
Tree Number: T4.9.77
database_cross_reference: NCI:C91617
database_cross_reference: NCI_PID:C91617

IL12 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic cells and macrophages in peripheral tissues act as antigen presenting cells and secrete IL-12 as one component of the antigen response, Th1 differentiation. The role of IL-12 in cellular immunity is largely mediated by the STAT-4 transcription factor. STAT-4 is essential for IL-12 activity and the phenotype of mice lacking STAT-4 is very similar to the phenotype of mice lacking the IL-12 receptor or IL-12. The role of IL-12 in Th1 differentiation may not be to induce the Th1 cell fate, but to stimulate growth of cells determined for the Th1 cell fate by the T-bet transcription factor. Several signaling pathways contribute to IL-12 activation of STAT-4 to regulate cell-mediated immune responses. The JAK kinases such as JAK2 and TYK2 interact with the activated IL-12 receptor and tyrosine phosphorylate the IL-12 receptor and STAT-4. IL-12 also activates a map kinase pathway activating the map kinase kinase MKK6 and p38. Phosphorylation of STAT-4 on serine 721 by p38 contributes to the full transcriptional activation of genes by STAT-4. Some of the events downstream of IL-12 appear to include genes activated indirectly by STAT-4, such as genes activated by the transcription factor ERM. ERM is in the Ets family of transcription factors, is activated by IL-12 and activates IL-12 inducible genes such as Interferon-gamma that are not activated by STAT-4 itself. Interferon-gamma transcription in T cells is also activated by other signals such as from the T cell receptor. Other proteins activated transcriptionally downstream of IL-12 and STAT-4 include the chemokine receptor CCR5 and IL-18 and its receptor. Some viruses, including HIV, repress cell-mediated immunity by blocking IL-12 signaling. (This definition may be outdated - see the DesignNote.)
MCID: MC00524000
PMOID: PMO:00014996
Subclass_of: Signaling Pathway
Synonym: IL12 and Stat4 Dependent Signaling Pathway in Th1 Development
Tree Number: T4.9.78
database_cross_reference: NCI:C39117
database_cross_reference: NCI_BioC:C39117

IL12-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393646
PMOID: PMO:00014997
Subclass_of: Signaling Pathway
Synonym: IL12-mediated signaling events
Synonym: Interleukin-12-Mediated Signaling
Tree Number: T4.9.79
database_cross_reference: NCI:C91615
database_cross_reference: NCI_PID:C91615

IL12/STAT4 Signaling Pathway
type: Class
subclass of: IL12-Mediated Signaling Pathway
MCID: MC01393647
PMOID: PMO:00014998
Subclass_of: IL12-Mediated Signaling Pathway
Synonym: IL12 signaling mediated by STAT4
Tree Number: T4.9.79.1
database_cross_reference: NCI:C91616
database_cross_reference: NCI_PID:C91616

IL17 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor for IL-17 is widely expressed throughout the body, including fibroblasts and epithelial cells. Inflammatory responses involving IL-17 probably contribute to arthritis, asthma, skin immune reactions, and autoimmune disorders. Fibroblasts and other cells stimulated by IL-17 are induced themselves to secrete inflammatory and hematopoietic cytokines, including IL-6, IL-8, G-CSF, and Stem Cell Factor (SCF). These cytokines in turn provoke a range of activities, including the stimulation of neutrophil proliferation and differentiation. (This definition may be outdated - see the DesignNote.)
MCID: MC00524001
PMOID: PMO:00014999
Subclass_of: Signaling Pathway
Synonym: IL 17 Signaling Pathway
Tree Number: T4.9.80
database_cross_reference: NCI:C39118
database_cross_reference: NCI_BioC:C39118

IL18 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: IL-18 is a pro-inflammatory cytokine similar in structure and mechanism of action to IL-1 beta. Formation of active IL-18 by macrophages requires cleavage of an inactive precursor by caspase-1 protease, also termed the IL-1 converting enzyme (ICE). One of the key biological responses induced by IL-18 is that, in combination with IL-12, it stimulates Th1 cell differentiation and involvement in immune responses. IL-18 was originally known as interferon-gamma-inducing factor, named after its induction of interferon-gamma production. Up-regulation of Fas ligand in Th1 cells by IL-18 may increase apoptosis of Fas receptor expressing cells that interact with the activated Th1 cells. This induction of apoptosis may allow IL-18 to have anti-tumor activity and may also play a role in chronic inflammatory and autoimmune conditions. (This definition may be outdated - see the DesignNote.)
MCID: MC00524002
PMOID: PMO:00015000
Subclass_of: Signaling Pathway
Synonym: IL 18 Signaling Pathway
Tree Number: T4.9.81
database_cross_reference: NCI:C39119
database_cross_reference: NCI_BioC:C39119

IL1R Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Interleukin-1 (IL-1) is a pro-inflammatory cytokine that signals primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include induction of fever, expression of vascular adhesion molecules, and roles in arthritis and septic shock. The inflammatory activities of IL-1 are partially derived by transcriptionally inducing expression of cytokines such as TNF-alpha and interferons, as well as inducing the expression of other inflammation-related genes. There are two forms of IL-1 encoded by distinct genes, IL-1 alpha and IL-1 beta. IL-1 beta is produced as a 269 amino acid precursor that is cleaved by IL-1beta converting enzyme (ICE) to the active IL-1 beta form that is secreted. IL-1 signaling is opposed by the naturally occurring peptide IL-1 receptor antagonist which is a therapeutic agent for the treatment of arthritis. The type 1 IL-1 receptor protein binds IL-1 beta but requires the IL-1 receptor accessory protein (IL-1RAcP) to transduce a signal. IL-1 binding causes activation of two kinases, IRAK-1 and IRAK-2, associated with the IL-1 receptor complex. IRAK-1 (IL-1 Receptor Associated Kinase) activates and recruits TRAF6 to the IL-1 receptor complex. TRAF6 activates two pathways, one leading to NF-kB activation and another leading to c-jun activation. The TRAF associated protein ECSIT leads to c-Jun activation through the Map kinase/JNK signaling system. TRAF6 also signals through the TAB1/TAK1 kinases to trigger the degradation of I-kB, and activation of NF-kB. The IL-1 signaling cascade represents a highly conserved response to pathogens through evolution, with homologs in insects and even in plants. The signal transduction cascade utilized by IL-1 receptor is similar to that of TNF, resulting in NF-kB activation, and is most similar to that of the Toll-like receptors that also participate in inflammatory signaling responses to pathogen components like endotoxin (see Toll-like receptor pathway). (This definition may be outdated - see the Des…
MCID: MC00524003
PMOID: PMO:00015001
Subclass_of: Signaling Pathway
Synonym: Signal transduction through IL1R
Tree Number: T4.9.82
database_cross_reference: NCI:C39120
database_cross_reference: NCI_BioC:C39120

IL2 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Interleukin 2 (IL-2) is a potent cytokine that can lead to cellular activation and proliferation. IL-2 receptors are found on activated B-cells, LPS treated monocytes, and many T-cells. The receptor is formed from three chains, alpha (CD25), beta (CD122), and gamma (CD132). Primary signaling is through the JAK/Stat pathway and MAPKs. (This definition may be outdated - see the DesignNote.)
MCID: MC00524006
PMOID: PMO:00015002
Subclass_of: Signaling Pathway
Synonym: IL 2 signaling pathway
Tree Number: T4.9.83
database_cross_reference: NCI:C39122
database_cross_reference: NCI_BioC:C39122

IL2-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393692
PMOID: PMO:00015003
Subclass_of: Signaling Pathway
Synonym: IL2-mediated signaling events
Synonym: Interleukin-2-Mediated Signaling
Tree Number: T4.9.84
database_cross_reference: NCI:C91620
database_cross_reference: NCI_PID:C91620

IL2/PI3K Signaling Pathway
type: Class
subclass of: IL2-Mediated Signaling Pathway
MCID: MC01393695
PMOID: PMO:00015004
Subclass_of: IL2-Mediated Signaling Pathway
Synonym: IL2 signaling events mediated by PI3K
Tree Number: T4.9.84.1
database_cross_reference: NCI:C91621
database_cross_reference: NCI_PID:C91621

IL2/STAT5 Signaling Pathway
type: Class
subclass of: IL2-Mediated Signaling Pathway
MCID: MC01393669
PMOID: PMO:00015005
Subclass_of: IL2-Mediated Signaling Pathway
Synonym: IL2 signaling events mediated by STAT5
Tree Number: T4.9.84.2
database_cross_reference: NCI:C91622
database_cross_reference: NCI_PID:C91622

IL22 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C. One of the actions of IL-22 appears to be the induction of acute phase inflammatory response in hepatocytes, acting through activation of STATs and transcriptional regulation. A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains. The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor. The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses. The IL-22 soluble receptor may act as an anti-inflammatory agent. (This definition may be outdated - see the DesignNote.)
MCID: MC00524004
PMOID: PMO:00015006
Subclass_of: Signaling Pathway
Synonym: IL22 Soluble Receptor Signaling Pathway
Tree Number: T4.9.85
database_cross_reference: NCI:C39121
database_cross_reference: NCI_BioC:C39121

IL23-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393686
PMOID: PMO:00015007
Subclass_of: Signaling Pathway
Synonym: IL23-mediated signaling events
Tree Number: T4.9.86
database_cross_reference: NCI:C91618
database_cross_reference: NCI_PID:C91618

IL27-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393688
PMOID: PMO:00015008
Subclass_of: Signaling Pathway
Synonym: IL27-mediated signaling events
Tree Number: T4.9.87
database_cross_reference: NCI:C91619
database_cross_reference: NCI_PID:C91619

IL3 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific alpha chain (70 kD, CD123) and a common beta chain (shared with IL-5 and GM-CSF). Signaling is believed to be primarily through Stat5 and the MAPK pathways. (This definition may be outdated - see the DesignNote.)
MCID: MC00524007
PMOID: PMO:00015009
Subclass_of: Signaling Pathway
Synonym: IL 3 signaling pathway
Tree Number: T4.9.88
database_cross_reference: NCI:C39124
database_cross_reference: NCI_BioC:C39124

IL4 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Interleukin 4 (IL-4) is a cytokine that can lead to development of Th2 cells. The 140 kD IL-4 Receptor (CD124) is found on many cell types, even those of non-hematopoietic origin. The receptor is formed from two chains: IL-4R-alpha and the IL-2R gamma chain (CD132). Primary signaling is through the JAK/Stat6 pathway and MAPKs. (This definition may be outdated - see the DesignNote.)
MCID: MC00524008
PMOID: PMO:00015010
Subclass_of: Signaling Pathway
Synonym: IL 4 signaling pathway
Tree Number: T4.9.89
database_cross_reference: NCI:C39125
database_cross_reference: NCI_BioC:C39125

IL4-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393673
PMOID: PMO:00015011
Subclass_of: Signaling Pathway
Synonym: IL4-mediated signaling events
Tree Number: T4.9.90
database_cross_reference: NCI:C91623
database_cross_reference: NCI_PID:C91623

IL5 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: IL-5 is an inflammatory signaling molecule that primarily stimulates eosinophil proliferation, maturation, and activation. Eosinophils are leukocytes involved in inflammatory responses that defend against parasites and cause some aspects of asthma, allergic reactions, and perhaps autoimmune disorders. The action of IL-5 begins with an immune response in tissues, such as activation of macrophages and T cells that secrete IL-1, IL-4, and IL-6. The immune response can lead to IL-5 secretion by T cells, eosinophils, and mast cells. Secreted IL-5 stimulates production and maturation of eosinophils in bone marrow that migrate to tissues in response to eotaxin and release factors that damage tissues, causing some of the undesirable consequences of inflammation. The receptor for IL-5 is a heterodimer of an alpha subunit that is required for IL-5 selective binding and a beta subunit that is also part of the IL-3 and GM-CSF receptors. Binding of IL-5 to the IL-5 receptor at the cell surface activates JAK/STAT signaling pathways that regulate transcription, proliferation, and differentiation. (This definition may be outdated - see the DesignNote.)
MCID: MC00524009
PMOID: PMO:00015012
Subclass_of: Signaling Pathway
Synonym: IL 5 Signaling Pathway
Tree Number: T4.9.91
database_cross_reference: NCI:C39126
database_cross_reference: NCI_BioC:C39126

IL6 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Interleukin-6 (IL-6) is a cytokine that provokes a broad range of cellular and physiological responses. In addition to playing a role in inflammation and hematopoiesis, IL-6 is involved in other processes such as neuronal differentiation and bone loss. To produce these effects IL-6 signals through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and gp130, a receptor subunit shared in common with other cytokines in the IL-6 family. Binding of IL-6 to its receptor initiates cellular events including activation of JAK kinases and activation of ras-mediated signaling. Activated JAK kinases phosphorylate and activate STAT transcription factors, particularly STAT3, that move into the nucleus to activate transcription of genes containing STAT3 response elements. The ras-mediated pathway, acting through Shc, Grb-2 and Sos-1 upstream and activating Map kinases downstream, activates transcription factors such as ELK-1 and NF-IL-6 (C/EBP-beta) that can act through their own cognate response elements in the genome. These factors and other transcription factors like AP-1 and SRF (serum response factor) that respond to many different signaling pathways come together to regulate a variety of complex promoters and enhancers that respond to IL-6 and other signaling factors. (This definition may be outdated - see the DesignNote.)
MCID: MC00524010
PMOID: PMO:00015013
Subclass_of: Signaling Pathway
Synonym: IL 6 signaling pathway
Tree Number: T4.9.92
database_cross_reference: NCI:C39127
database_cross_reference: NCI_BioC:C39127

IL6-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393674
PMOID: PMO:00015014
Subclass_of: Signaling Pathway
Synonym: IL6-mediated signaling events
Tree Number: T4.9.93
database_cross_reference: NCI:C91624
database_cross_reference: NCI_PID:C91624

IL7 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T cells. Some humans with SCID (severe combined immunodeficiency disease) also have mutation of their IL-7 receptor gene leading to an absence of T cells and greatly impaired B cell production. The IL-7 receptor includes two polypeptides, a gamma chain and an alpha chain. The alpha-chain is unique to the IL-7 receptor while several other cytokines use the same gamma receptor chain as IL-7, including IL-2, IL-4, IL-9, IL-15 and IL-21. Binding of IL-7 to the alpha chain leads to dimerization of the alpha and gamma chains. JAK3 associated with the gamma chain tyrosine phosphorylates the alpha chain after dimerization. The importance of JAK3 in IL-7 signaling is supported by the similarity of the immune defects in JAK3 knockout mice and IL-7 knockout mice. The phosphorylated alpha chain serves as the site for recruiting other signaling molecules to the complex to be phosphorylated and activated, including STAT5, src kinases, PI3 kinase, Pyk2, and Bcl2 proteins. Some targets of IL-7 signaling contribute to cellular survival, including Bcl2 and Pyk2. Other targets contribute to cellular proliferation, including PI3 kinase, src family kinases (lck and fyn) and STAT5. The transcription factor STAT5 contributes to activation of multiple different downstream genes in B and T cells and may contribute to VDJ recombination through alteration of chromatin structure. The cell survival and cell proliferation signals induced by IL-7 combine to induce normal B and T cell development. (This definition may be outdated - see the DesignNote.)
MCID: MC00524011
PMOID: PMO:00015015
Subclass_of: Signaling Pathway
Synonym: IL-7 Signal Transduction
Tree Number: T4.9.94
database_cross_reference: NCI:C39128
database_cross_reference: NCI_BioC:C39128

Insulin Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393676
PMOID: PMO:00015016
Subclass_of: Signaling Pathway
Tree Number: T4.9.95
database_cross_reference: NCI:C91625
database_cross_reference: NCI_PID:C91625

Insulin-Mediated Glucose Transport Pathway
type: Class
subclass of: Insulin Pathway
MCID: MC01393679
PMOID: PMO:00015017
Subclass_of: Insulin Pathway
Synonym: Insulin-mediated glucose transport
Tree Number: T4.9.95.1
database_cross_reference: NCI:C91626
database_cross_reference: NCI_PID:C91626

Insulin Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The appropriate signaling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a complex with the insulin receptor (IR) and b chains to form the active signaling complex. Through recruitment of adaptor molecules and the activation of RAS, the activated IR can cause transcriptional activation. (This definition may be outdated - see the DesignNote.)
MCID: MC00524124
PMOID: PMO:00015018
Subclass_of: Signaling Pathway
Tree Number: T4.9.96
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39130
database_cross_reference: NCI_BioC:C39130

Insulin/Insulin Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
MCID: MC00815368
PMOID: PMO:00015019
Subclass_of: Signaling Pathway
Synonym: Insulin signaling pathway
Tree Number: T4.9.97
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91489
database_cross_reference: NCI_KEGG:C91489

Integrin Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals in response to the extracellular matrix including cellular shape, mobility, and progression through the cell cycle. Integrins do not themselves possess a kinase domain or enzymatic activity but rely on association with other signaling molecules to transmit signals. Interactions between the extracellular matrix and the actin cytoskeleton commonly take place at focal adhesions on the cell surface that contain localized concentrations of integrins, signaling molecules, and cytoskeletal elements. Talin forms a direct interaction with the integrin cytoplasmic domain, and interacts with cytoskeletal elements (actin) and signaling factors. Paxillin and CAS also localize in focal adhesions and may serve as a scaffold for other integrin signaling components like FAK and src. Interaction of FAK, CAS and src may be required for integrin regulation of cell cycle progression. The CrkL adaptor protein may regulate downstream integrin signaling. Growth factor signaling pathways and the caveolin receptor exhibit important cross talk with integrin receptors in cellular responses like activation of map kinase, proliferation and motility. (This definition may be outdated - see the DesignNote.)
MCID: MC00524127
PMOID: PMO:00015020
Subclass_of: Signaling Pathway
Tree Number: T4.9.98
database_cross_reference: NCI:C39131
database_cross_reference: NCI_BioC:C39131

Interferon Signaling Modulation Pathway
type: Class
subclass of: Signaling Pathway
Definition: Signaling by interferon-gamma stimulates anti-viral responses and tumor suppression through the heterodimeric interferon-gamma receptor. Signaling is initiated by binding of interferon-gamma to its receptor, activating the receptor-associated JAK2 tyrosine kinase to phosphorylate STAT transcription factors that activate interferon responsive genes. Molecular chaperones that modulate or alter protein folding interact with different components of the interferon signaling pathway. One chaperone that modulates interferon signaling is hTid-1, a member of the DnaJ family of chaperones and a co-chaperone for the heat shock protein Hsp70, another molecular chaperone. hTid-1 was found in a two-hybrid screen to bind to JAK2 and also to interact with the interferon-gamma receptor. In addition, hTid-1 and JAK2 also interact with Hsp70. Overexpression of hTid-1 represses transcriptional activation by interferon-gamma and Hsp70 dissociates from these proteins when interferon is added to cells, suggesting that Hsp70 holds Jak2 in an inactive conformation prior to ligand activation, and is released in the presence of agonist to allow the activation of Jak-2 and downstream pathways. hTid-1 and Hsp-70 interact with other signaling proteins as well. One of these is Tax, a protein encoded by the HTLV-1 virus that binds to hTid-1. hTid-1 also represses NF-kB activation by blocking the phosphorylation and inactivation of I-kappaB by the IkappaB kinase beta. Hsp70 plays a significant role in protein unfolding for entry into mitochondria and also interacts with tumor suppressor gene products to produce their anti-proliferative activity. One of the actions of interferon is to induce apoptosis of infected target cells, in part through a mitochondrial dependent mechanism. An interaction between interferon signaling and Hsp70 may alter this mitochondrial apoptosis pathway, perhaps playing a role in interferon-mediated apoptosis of infected or transformed cells. The HTLV-1 Tax protein that inte…
MCID: MC00524141
PMOID: PMO:00015021
Subclass_of: Signaling Pathway
Synonym: Chaperones modulate interferon Signaling Pathway
Tree Number: T4.9.99
database_cross_reference: NCI:C39253
database_cross_reference: NCI_BioC:C39253

Interferon-Gamma Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393644
PMOID: PMO:00015022
Subclass_of: Signaling Pathway
Synonym: IFN-gamma pathway
Tree Number: T4.9.100
database_cross_reference: NCI:C91613
database_cross_reference: NCI_PID:C91613

Ion Channel and Phorbal Esters Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Molecules transmitting signals into cells often act through receptors in the plasma membrane that stimulate production of second messengers. When activated by a plasma membrane receptor, the enzyme phospholipase C (PLCg) hydrolyzes the membrane lipid phosphatidylinositol (PIP2) into the second messengers diacylglycerol (DAG) and IP3. IP3 releases calcium from intracellular stores into the cytoplasm where calcium alters many cellular activities, including activating protein kinase C. DAG also activates protein kinase C. Biologists often study signaling by artificially manipulating pathways using molecules like ionomycin and phorbol esters as research tools. Ionomycin is a molecule that carries calcium through the plasma membrane to increase the calcium concentration in the cytoplasm and activate protein kinase C without activating phospholipase C. Phorbol esters are molecules that mimic the action of DAG in the activation of protein kinase C, and were originally identified as tumor-promoting agents. The combination of ionomycin and phorbol esters is often used experimentally to study the effect of calcium and DAG signaling in cellular responses like T cell activation. (This definition may be outdated - see the DesignNote.)
MCID: MC00526704
PMOID: PMO:00015023
Subclass_of: Signaling Pathway
Tree Number: T4.9.101
database_cross_reference: NCI:C39133
database_cross_reference: NCI_BioC:C39133

Jak-STAT Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
MCID: MC01393859
PMOID: PMO:00015024
Subclass_of: Signaling Pathway
Synonym: Jak-STAT signaling pathway
Tree Number: T4.9.102
database_cross_reference: NCI:C91519
database_cross_reference: NCI_KEGG:C91519

LKB1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393841
PMOID: PMO:00015025
Subclass_of: Signaling Pathway
Synonym: LKB1 signaling events
Synonym: STK11 Signaling Pathway
Tree Number: T4.9.103
database_cross_reference: NCI:C91631
database_cross_reference: NCI_PID:C91631

Lysophosphatidic Acid Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393845
PMOID: PMO:00015026
Subclass_of: Signaling Pathway
Synonym: LPA receptor mediated events
Tree Number: T4.9.104
database_cross_reference: NCI:C91632
database_cross_reference: NCI_PID:C91632

Lysophosphatidic Acid Receptor 4 Signaling Pathway
type: Class
subclass of: Lysophosphatidic Acid Receptor Signaling Pathway
MCID: MC01393816
PMOID: PMO:00015027
Subclass_of: Lysophosphatidic Acid Receptor Signaling Pathway
Synonym: LPA4-mediated signaling events
Tree Number: T4.9.104.1
database_cross_reference: NCI:C91633
database_cross_reference: NCI_PID:C91633

Macrophage Stimulating 1 Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: MSP, macrophage-stimulating protein, acts through the transmembrane receptor kinase RON (Stk in mice) to play a role in inflammation and the response to tissue injury. MSP is secreted by the liver into the blood as pro-MSP, an inactive precursor form. MSP is related to clotting factors that are activated by proteolytic cleavage and pro-MSP is itself also activated by cleavage to MSP. Binding of activated MSP heterodimer to RON expressed on macrophages, monocytes and keratinocytes stimulates activation of the RON kinase and second messenger pathways, including PI-3 kinase. Macrophages respond to MSP with changes in cell shape and motility and keratinocytes respond by proliferating. Tissue injury leads to pro-MSP cleavage and activation, and macrophages and keratinocytes that respond to MSP are key cells in tissue injury response, supporting a role for MSP and RON in the response to tissue injury. The interaction of MSP and macrophages at sites of inflammation such as infection also depends on chemotactic factors such as MCP1 and inflammatory cytokines such as IL-1 and TNF that attract and activate immune cells in the affected tissue. (This definition may be outdated - see the DesignNote.)
MCID: MC00527051
PMOID: PMO:00015028
Subclass_of: Signaling Pathway
Synonym: Msp/Ron Receptor Signaling Pathway
Tree Number: T4.9.105
database_cross_reference: NCI:C39157
database_cross_reference: NCI_BioC:C39157

MAPK Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
MCID: MC00527013
PMOID: PMO:00015029
Subclass_of: Signaling Pathway
Tree Number: T4.9.106
database_cross_reference: NCI:C38834
database_cross_reference: NCI_KEGG:C38834

MAPKinase Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major groupings and numerous related proteins which constitute interrelated signal transduction cascades activated by stimuli such as growth factors, stress, cytokines and inflammation. The four major groupings are the Erk, JNK or SAPK, p38, and the Big MAPK or ERK5 cascades. Signals from cell surface receptors such as GPCRs and growth factor receptors are transduced, directly or via small G proteins such as ras and rac, to multiple tiers of protein kinases that amplify these signals and/or regulate each other. In some cascades the first activation tier involves the MAPKKKKs, MAP kinase kinase kinase kinases or MAP4K proteins. The next tier are the serine/threonine MAPKKKs, MAP kinase kinase kinase or MAP3Ks such as RAF, TAK, ASK, and MEKK1. This level has the greatest amount of cross-communication currently known. The serine/threonine/tyrosine MAPKKs, MAP Kinase kinases or MAP2Ks, such as the MKK and MEK kinases, are one step up from the MAP kinase cascade, phosphorylating and activating these kinases. The focal tier, the MAPKs or MAP kinases includes JNK1, p38, and ERKs, and are the kinases that give each cascade its name. The endpoints of these cascades include the MAPK activated protein kinases (MAPKAPK) and some of the numerous transcription factors that regulate genes involved in apoptosis, inflammation, cell growth and differentiation. (This definition may be outdated - see the DesignNote.)
MCID: MC00527014
PMOID: PMO:00015030
Subclass_of: Signaling Pathway
Tree Number: T4.9.107
database_cross_reference: NCI:C39146
database_cross_reference: NCI_BioC:C39146

Mast/Stem Cell Growth Factor Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00815385
PMOID: PMO:00015031
Subclass_of: Signaling Pathway
Synonym: KIT Signaling Pathway
Synonym: Kit signaling pathway
Synonym: Kit signalling pathway
Synonym: SCF signaling pathway
Synonym: Signaling events mediated by Stem cell factor receptor (c-Kit)
Synonym: stem cell factor receptor signaling pathway
Synonym: stem cell factor signaling pathway
Tree Number: T4.9.108
database_cross_reference: GO:GO:0038109
database_cross_reference: NCI:C91679
database_cross_reference: NCI_PID:C91679

Mitochondria in Apoptotic Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase pathway. Smac/DIABLO is released from mitochondria and inhibits IAP proteins that normally interact with caspase-9 to inhibit apoptosis. Apoptosis regulation by Bcl-2 family proteins occurs as family members form complexes that enter the mitochondrial membrane, regulating the release of cytochrome c and other proteins. TNF family receptors that cause apoptosis directly activate the caspase cascade, but can also activate Bid, a Bcl-2 family member, which activates mitochondria-mediated apoptosis. Bax, another Bcl-2 family member, is activated by this pathway to localize to the mitochondrial membrane and increase its permeability, releasing cytochrome c and other mitochondrial proteins. Bcl-2 and Bcl-xL prevent pore formation, blocking apoptosis. AIF (apoptosis inducing factor) is another mitochondrial factor that is released into the cytoplasm to induce apoptosis. AIF-induced apoptosis is important during development but is not caspase dependent. (This definition may be outdated - see the DesignNote.)
MCID: MC00524413
PMOID: PMO:00015032
Subclass_of: Signaling Pathway
Synonym: Role of Mitochondria in Apoptotic Signaling
Tree Number: T4.9.109
database_cross_reference: NCI:C39154
database_cross_reference: NCI_BioC:C39154

mTOR Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
Definition: mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate translation. The drug rapamycin acts on mammalian cells through the mTOR protein kinase, also known as FRAP. When bound to the immunophilin binding protein FKBP12, rapamycin inhibits mTOR kinase activity and has immunosuppressant activity. Rapamycin and the mTOR inhibitor CCI-779 are being tested as anti-cancer agents, acting to block mitogenic signaling. Recently, mTOR was also found to act as an ATP sensor to regulate cell growth. Upstream activation of PI 3 kinase activity that leads to oncogenic transformation can be blocked by inhibition of mTOR by rapamycin. Growth factor receptors first stimulate PI 3 kinase, and through inositol phosphates activate PDK-1 and AKT (protein kinase B). AKT phosphorylates mTOR. The phosphorylation of p70S6K and 4EBP by mTOR and the phosphorylation downstream of RPS6 and EIF-4B stimulate translational initiation and contribute to cell growth. (This definition may be outdated - see the DesignNote.)
MCID: MC00525729
PMOID: PMO:00015033
Subclass_of: Signaling Pathway
Synonym: mTOR Signaling Pathway
Tree Number: T4.9.110
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39159
database_cross_reference: NCI_BioC:C39159

mTOR Signaling Pathway KEGG
type: Class
subclass of: Signaling Pathway
MCID: MC00815363
PMOID: PMO:00015034
Subclass_of: Signaling Pathway
Synonym: mTOR signaling pathway
Tree Number: T4.9.111
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91431
database_cross_reference: NCI_KEGG:C91431

mTOR Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
MCID: MC00815377
PMOID: PMO:00015035
Subclass_of: Signaling Pathway
Synonym: mTOR signaling pathway
Tree Number: T4.9.112
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91634
database_cross_reference: NCI_PID:C91634

N-Cadherin Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393822
PMOID: PMO:00015036
Subclass_of: Signaling Pathway
Synonym: N-cadherin signaling events
Tree Number: T4.9.113
database_cross_reference: NCI:C91635
database_cross_reference: NCI_PID:C91635

Nectin Adhesion Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393826
PMOID: PMO:00015037
Subclass_of: Signaling Pathway
Synonym: Nectin adhesion pathway
Tree Number: T4.9.114
database_cross_reference: NCI:C91636
database_cross_reference: NCI_PID:C91636

Nerve Growth Factor Pathway
type: Class
subclass of: Signaling Pathway
Definition: Nerve growth factor (NGF) is one of a family of neurotrophins that induce the survival and proliferation of neurons. In cell culture NGF induces the formation of neurite projections and in vivo may stimulate the innervation of tissues. NGF plays a role in the repair, regeneration, and protection of neurons, and as such could serve as a therapeutic agent in neurodegenerative conditions such as Alzheimer's disease. One potential method of NGF application would be through gene therapy or through implantation of cells that have been genetically modified ex vivo. NGF has also been suggested to play a role in other physiological systems and tissues such as the immune system. NGF has two receptors, TrkA and the p75(NTR). NGF may signal its neuroprotective actions through the tyrosine kinase TrkA receptor and trigger apoptosis in some cells through the p75 receptor. High-affinity binding of NGF requires both TrkA and p75(NTR). Binding of NGF to the TrkA receptor causes activation of the receptor tyrosine kinase and downstream signaling cascades. One of the downstream signaling pathways of NGF activates phospholipase C, releasing DAG and IP3 and activating associated downstream pathways such as protein kinase C. Another NGF-activated pathway is the ras-mediated activation of the map kinase pathway. This pathway is initiated through recruitment and activation of Shc, which leads to ras activation through Grb-2 and Sos-1. The Map kinase cascade includes raf, Mek and Erk. The downstream effectors of the ras pathway include activation of fos and jun to form AP-1, activating genes through this transcription factor. Other transcription factors involved in NGF responses include Egr and CREB. The Egr family of transcription factors, as well as the Mek/Erk pathway, contribute to NGF-induced neurite formation. The CREB family of transcription factors are involved in NGF-induced survival of sympathetic neurons. Further understanding of NGF signaling may be applied to the modulation of …
MCID: MC00524776
PMOID: PMO:00015038
Subclass_of: Signaling Pathway
Synonym: Nerve growth factor pathway (NGF)
Tree Number: T4.9.115
database_cross_reference: NCI:C39164
database_cross_reference: NCI_BioC:C39164

Neuroactive Ligand-Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394090
PMOID: PMO:00015039
Subclass_of: Signaling Pathway
Synonym: Neuroactive ligand-receptor interaction
Tree Number: T4.9.116
database_cross_reference: NCI:C91438
database_cross_reference: NCI_KEGG:C91438

Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393866
PMOID: PMO:00015040
Subclass_of: Signaling Pathway
Synonym: High Affinity Nerve Growth Factor Receptor Signaling Pathway
Synonym: Neurotrophic factor-mediated Trk receptor signaling
Tree Number: T4.9.117
database_cross_reference: NCI:C91638
database_cross_reference: NCI_PID:C91638

NTRK1/MAPK Signaling Pathway
type: Class
subclass of: Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
MCID: MC01394096
PMOID: PMO:00015041
Subclass_of: Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
Synonym: Trk receptor signaling mediated by the MAPK pathway
Tree Number: T4.9.117.1
database_cross_reference: NCI:C91695
database_cross_reference: NCI_PID:C91695

NTRK1/PI3K/PLC-Gamma Signaling Pathway
type: Class
subclass of: Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
MCID: MC01394094
PMOID: PMO:00015042
Subclass_of: Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
Synonym: Trk receptor signaling mediated by PI3K and PLC-gamma
Tree Number: T4.9.117.2
database_cross_reference: NCI:C91694
database_cross_reference: NCI_PID:C91694

NFKB Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Nuclear factor kB (NF-kB) is a nuclear transcription factor that regulates expression of a large number of genes that are critical for the regulation of apoptosis, viral replication, tumorigenesis, inflammation, and various autoimmune diseases. The activation of NF-kB is thought to be part of a stress response as it is activated by a variety of stimuli that include growth factors, cytokines, lymphokines, UV, pharmacological agents, and stress. In its inactive form, NF-kB is sequestered in the cytoplasm, bound by members of the IkB family of inhibitor proteins, which include IkBa, IkBb, IkBg, and IkBe. The various stimuli that activate NF-kB cause phosphorylation of IkB, which is followed by its ubiquitination and subsequent degradation. This results in the exposure of the nuclear localization signals (NLS) on NF-kB subunits and the subsequent translocation of the molecule to the nucleus. In the nucleus, NF-kB binds with a consensus sequence (5'GGGACTTTCC-3') of various genes and thus activates their transcription. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins; IKK1/IKKa, IKK2/IKKb, and IKK3/IKKg. These enzymes phosphorylate IkB leading to its ubiquitination and degradation. Tumor necrosis factor (TNF) which is the best-studied activator binds to its receptor and recruits a protein called TNF receptor death domain (TRADD). TRADD binds to the TNF receptor-associated factor 2 (TRAF-2) that recruits NF-kB-inducible kinase (NIK). Both IKK1 and IKK2 have canonical sequences that can be phosphorylated by the MAP kinase NIK/MEKK1 and both kinases can independently phosphorylate IkBa or IkBb. TRAF-2 also interacts with A20, a zinc finger protein whose expression is induced by agents that activate NF-kB. A20 functions to block TRAF2-mediated NF-kB activation. A20 also inhibits TNF and IL-1 induced activation of NF-kB suggesting that it may act as a general inhibitor of NF-kB activation. (This definition may be outdated - see the D…
MCID: MC00524576
PMOID: PMO:00015043
Subclass_of: Signaling Pathway
Synonym: NF-kB Signaling Pathway
Tree Number: T4.9.118
database_cross_reference: NCI:C39163
database_cross_reference: NCI_BioC:C39163

Nitric Oxide Pathway
type: Class
subclass of: Signaling Pathway
Definition: Nitric oxide (NO) has a number of important physiological actions in the cardiovascular system. In the heart, NO plays a role in keeping the vessels open via vasodilation and prevention of platelet aggregation. It also plays an important role in regulating the force and rate of contraction. In vivo NO is released by shear stress of ligands that increase intracellular Ca2+ in endothelial cells. The increased intracellular Ca2+ activates nitric oxide synthase III (NOSIII) by promoting the binding of Ca/Calmodulin to the enzyme. NOSIII, which is resident in the Golgi complex, is transported together with caveolin-1 to the caveolae at the plasma membrane via vesicles. Shear stress signals via a potassium channel and the cytoskeleton, which results in tyrosine phosphorylation of specific proteins, activation of phosphatidylinositol 3-kinase, and subsequently in activation of Akt kinase. Akt activation by shear stress, but also by VEGF, activates NOSIII by serine phosphorylation, which increases the affinity of NOSIII for calmodulin. After agonist binding at the plasma membrane, NOSIII-activating receptors translocate to caveolae. VEGF receptor signals via its tyrosine kinase domain. Furthermore, agonist receptors activate calcium channels of the endoplasmic reticulum (ER) via phospholipase C and inositol 1,4,5-trisphosphate. This calcium flux induces binding of calmodulin to NOSIII, whereas the NOSIII-caveolin-1 interaction is disrupted. At the same time, NOSIII is translocated into the cytosol. On binding of calmodulin, NOSIII generates NO, is enhanced by the interaction with Hsp90. Once activated, NOSIII catabolizes L-arginine to NO, which diffuses out of the cell. NO stimulates guanylate (G-) cyclase and increases cGMP levels. cGMP activates cGMP-dependent protein kinase (PKG), cGMP-inhibited phosphodiesterase (PDEIII), and cGMP-stimulated phosphodiesterase (PDEII). PKG may reduce the force and rate of contraction, possibly by phosphorylating troponin I or by phosphor…
MCID: MC00527160
PMOID: PMO:00015044
Subclass_of: Signaling Pathway
Synonym: Actions of Nitric Oxide in the Heart
Tree Number: T4.9.119
database_cross_reference: NCI:C39167
database_cross_reference: NCI_BioC:C39167

Nitric Oxide Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Glutamatergic-mediated nitric oxide (NO) production occurs via the N-methyl-D-aspartic acid (NMDA) postsynaptic density protein 95 (PSD95)-neuronal nitric oxide synthase (NOS1) ternary complex. The increased intracellular Ca2+ stimulates the interaction of nNOS and calmodulin (CaM) and the translocation of nNOS from the plasma membrane to the cytoplasm. The dephosphorylation of nNOS by Calcineurin catalyzes the conversion of arginine to citrulline and nitric oxide (NO), which turns on guanylate cyclase and the various cGMP regulated signaling pathways. (This definition may be outdated - see the DesignNote.)
MCID: MC00527161
PMOID: PMO:00015045
Subclass_of: Signaling Pathway
Tree Number: T4.9.120
database_cross_reference: NCI:C39169
database_cross_reference: NCI_BioC:C39169

NOD-Like Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-kappa-B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway.
MCID: MC00815370
PMOID: PMO:00015046
Subclass_of: Signaling Pathway
Synonym: NOD-like receptor signaling pathway
Tree Number: T4.9.121
database_cross_reference: GO:GO:0035872
database_cross_reference: NCI:C91506
database_cross_reference: NCI_KEGG:C91506

Notch and Wnt Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Presenilin-1 (PS1) is associated with gamma secretase activity that cleaves amyloid precursor protein (APP) and is implicated in Alzheimer's disease. Presenilin-1 is also a component in gamma-secretase activity involved in signaling by the transmembrane protein Notch. Active gamma secretase requires PS-1 N-terminal fragment and a C-terminal fragment and is unique in catalyzing proteolysis within the transmembrane region of proteins. Other proteins such as nicastrin may also be components of the gamma-secretase. Binding of the ligand Delta by Notch appears to trigger two proteolytic cleavages of Notch. The first step cleaves an extracellular domain and is catalyzed by a metalloprotease termed alpha-secretase or TACE. The second cleavage step appears to occur within the transmembrane domain of Notch, and releases a Notch intracellular domain (NICD). Once released, NICD moves into the nucleus where it is involved in transcriptional regulation through CSL family transcription factors (CBF1, Su(H), Lag-1) or other transcriptional regulators such as LEF-1. Presenilin is also involved in the Wnt/frizzled signaling pathway through beta-catenin. Beta-catenin is a cytoskeletal component that enters the nucleus to act as a transcriptional cofactor. Binding of WNT to Frizzled causes disheveled (DSH) to inhibit Glycogen synthase kinase 3 beta (GSK-3b) activity. Phosphorylation of Beta-catenin induces the ubiquitination and proteolytic degradation of beta-catenin by the proteasome. Non-phosphorylated beta-catenin is stable and enters the nucleus to regulate transcription with TCF. The beta-catenin/TCF complex activates genes that promote cellular survival, proliferation and differentiation during development. Presenilin stimulates beta-catenin turnover, reducing its transcriptional activation. (This definition may be outdated - see the DesignNote.)
MCID: MC00527184
PMOID: PMO:00015047
Subclass_of: Signaling Pathway
Synonym: Presenilin action in Notch and Wnt signaling
Tree Number: T4.9.122
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39202
database_cross_reference: NCI_BioC:C39202

Notch Proteolysis and Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Notch is a large cell-surface receptor that is activated by contact with membrane-bound ligands on neighboring cells. The ligands that activate Notch include Delta and Serrate, and Lag-2 is a Notch ligand in C. elegans. Activation of Notch by binding with its ligand on the surface of neighboring cells is involved in several developmental pathways, helping to determine cell fate. Much of the early insight into Notch signaling was derived from genetic studies in Drosophila and C. elegans models. Three different proteolytic steps process the 300 kD precursor of mature Notch. One protease is a furin-like enzyme that cleaves Notch constitutively adjacent to the amino acid sequence RQRR in the extracellular domain. Another proteolytic step in Notch processing is carried out by TACE, also known as ADAM17. Binding of extracellular ligand to Notch also induces cleavage at the transmembrane region by a gamma-secretase activity that is dependent on presenilin-1. The exact identity of the polypeptide that catalyzes the gamma-secretase enzyme activity has been debated. Labeling of presenilin with irreversible gamma-secretase transition state inhibitors indicates that is itself in fact the site of protease activity. It has also been argued that the gamma secretase is not presenilin-1 itself, but another polypeptide that requires Notch for its activity and is distinct from Presenilin-1. Cleavage of Notch in the extracellular domain releases the Notch intracellular domain (BIOCARTAD) which migrates into the nucleus where it associates with CSL transcription factors and acts as a transcriptional coactivator. The proteolytic processing of Notch resembles in several ways the proteolytic processing of amyloid precursor protein (APP) that is implicated in plaque formation in Alzheimer's disease, with TACE and Presenilin-1 implicated in proteolytic processing of both Notch and APP. (This definition may be outdated - see the DesignNote.)
MCID: MC00388995
PMOID: PMO:00015048
Subclass_of: Signaling Pathway
Synonym: N signaling pathway
Synonym: N signalling pathway
Synonym: Notch Signaling Pathway
Synonym: Notch receptor signaling pathway
Synonym: Notch receptor signalling pathway
Synonym: Notch signaling pathway
Synonym: Notch signalling pathway
Synonym: Notch-receptor signaling pathway
Synonym: Notch-receptor signalling pathway
Synonym: Proteolysis and Signaling Pathway of Notch
Tree Number: T4.9.123
database_cross_reference: GO:GO:0007219
database_cross_reference: NCI:C39170
database_cross_reference: NCI:C91520
database_cross_reference: NCI_BioC:C39170
database_cross_reference: NCI_KEGG:C91520

Notch Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
MCID: MC00388995
PMOID: PMO:00015049
Subclass_of: Signaling Pathway
Synonym: N signaling pathway
Synonym: N signalling pathway
Synonym: Notch Proteolysis and Signaling Pathway
Synonym: Notch receptor signaling pathway
Synonym: Notch receptor signalling pathway
Synonym: Notch signaling pathway
Synonym: Notch signalling pathway
Synonym: Notch-receptor signaling pathway
Synonym: Notch-receptor signalling pathway
Synonym: Proteolysis and Signaling Pathway of Notch
Tree Number: T4.9.124
database_cross_reference: GO:GO:0007219
database_cross_reference: NCI:C39170
database_cross_reference: NCI:C91520
database_cross_reference: NCI_BioC:C39170
database_cross_reference: NCI_KEGG:C91520

Olfactory Transduction Pathway
type: Class
subclass of: Signaling Pathway
Definition: Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP. Longer exposure to odorants can stimulate particulate guanylyl cyclase in cilia to produce cGMP and activate PKG, leading to a further increase in amount and duration of intracellular cAMP levels, which may serve to convert inactive forms of protein kinase A (PKA2) to active forms (PKA*). As part of a feedback loop, PKA can inhibit the activation of particulate guanylyl cyclase.
MCID: MC01393769
PMOID: PMO:00015050
Subclass_of: Signaling Pathway
Synonym: Olfactory transduction
Synonym: olfactory transduction
Tree Number: T4.9.125
database_cross_reference: NCI:C91530
database_cross_reference: NCI_KEGG:C91530
database_cross_reference: NCI_NCI-GLOSS:CDR0000462728

OX40 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Two key features of the immune system are the clonal expansion of B cells and T cells in response to antigens, and the potentiation of future immune responses by long-lived memory cells. CD4-expressing T cells require costimulatory signals along with antigen stimulation to mount an effective immune response. CD28 has been widely characterized as a costimulatory receptor for CD4+ T cells. OX40, also called CD134, is another transmembrane receptor protein expressed by CD4 T cells that provides a costimulatory signal for T cell activation by antigen. The OX40L ligand for OX40 is expressed as a transmembrane protein by antigen-presenting cells, and is required for function of antigen-presenting cells. The T cell costimulatory signal provided by the OX40/OX40L interaction increases the clonal amplification of antigen-specific T cells and the survival of memory T cells that respond to this antigen. (This definition may be outdated - see the DesignNote.)
MCID: MC00527214
PMOID: PMO:00015051
Subclass_of: Signaling Pathway
Tree Number: T4.9.126
database_cross_reference: NCI:C39175
database_cross_reference: NCI_BioC:C39175

p38 MAPK Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
Definition: p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, and Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/5. The p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, Max/Myc complex, MEF-2, ELK-1, and indirectly CREB via activation of MSK1. (This definition may be outdated - see the DesignNote.)
MCID: MC00525734
PMOID: PMO:00015052
Subclass_of: Signaling Pathway
Synonym: p38 MAPK Signaling Pathway
Tree Number: T4.9.127
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39178
database_cross_reference: NCI_BioC:C39178

p38 MAPK Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
MCID: MC00815378
PMOID: PMO:00015053
Subclass_of: Signaling Pathway
Synonym: p38 MAPK signaling pathway
Tree Number: T4.9.128
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91642
database_cross_reference: NCI_PID:C91642

p38 MAPK/MAPKAP Signaling Pathway
type: Class
subclass of: p38 MAPK Signaling Pathway PID
MCID: MC01393880
PMOID: PMO:00015054
Subclass_of: p38 MAPK Signaling Pathway PID
Synonym: p38 signaling mediated by MAPKAP kinases
Tree Number: T4.9.128.1
database_cross_reference: NCI:C91643
database_cross_reference: NCI_PID:C91643

p38-alpha and p38-beta Signaling Pathway
type: Class
subclass of: p38 MAPK Signaling Pathway PID
MCID: MC01394224
PMOID: PMO:00015055
Subclass_of: p38 MAPK Signaling Pathway PID
Synonym: Signaling mediated by p38-alpha and p38-beta
Tree Number: T4.9.128.2
database_cross_reference: NCI:C91682
database_cross_reference: NCI_PID:C91682

p38-gamma and p38-delta Signaling Pathway
type: Class
subclass of: p38 MAPK Signaling Pathway PID
MCID: MC01394228
PMOID: PMO:00015056
Subclass_of: p38 MAPK Signaling Pathway PID
Synonym: Signaling mediated by p38-gamma and p38-delta
Tree Number: T4.9.128.3
database_cross_reference: NCI:C91683
database_cross_reference: NCI_PID:C91683

Regulation of p38-alpha and p38-beta Pathway
type: Class
subclass of: p38 MAPK Signaling Pathway PID
MCID: MC01393800
PMOID: PMO:00015057
Subclass_of: p38 MAPK Signaling Pathway PID
Synonym: Regulation of p38-alpha and p38-beta
Tree Number: T4.9.128.4
database_cross_reference: NCI:C91662
database_cross_reference: NCI_PID:C91662

Pain Repression Pathway
type: Class
subclass of: Signaling Pathway
Definition: The molecular events that lead to the perception of pain are a key research field in medicine and drug discovery. The opioid receptors modulate pain signaling in response to endogenous peptide ligands and opiate drugs such as morphine. The kappa opioid receptor plays a key role in the profound analgesia of opiates and is activated by the endogenous peptide ligand dynorphin, encoded by the prodynorphin gene. Production of prodynorphin is transcriptionally regulated by a downstream regulatory element (DRE) in the prodynorphin gene. A transcription factor called DREAM (DRE antagonistic modulator) binds to the DRE and represses prodynorphin transcription when bound. DREAM binds calcium with 4 EF-hand motifs and the binding of DREAM to DNA is repressed in the presence of calcium. Many transcription factors are regulated by calcium indirectly through calcium sensitive kinases and phosphatases, but DREAM is unique to date in being a transcription factor that directly binds calcium and is regulated by calcium binding. DREAM may also regulate other genes such as c-fos. DREAM is expressed in spinal cord neurons in regions involved in pain signaling. The regulation of prodynorphin expression by DREAM also leads to the hypothesis that DREAM is involved in pain signaling. Transgenic mice lacking the DREAM gene were unusually pain insensitive and had elevated spinal levels of dynorphin and tonic activation of the kappa opioid receptor, supporting this hypothesis. Other functions of DREAM may exist such as regulation of presenilins and potassium channel activity in the heart. DREAM is also known as calsenilin and KChIP3 through its association with these other proteins. These processes were not affected in mice lacking the DREAM gene however. (This definition may be outdated - see the DesignNote.)
MCID: MC00527383
PMOID: PMO:00015058
Subclass_of: Signaling Pathway
Synonym: Repression of Pain Sensation by the Transcriptional Regulator DREAM
Tree Number: T4.9.129
database_cross_reference: NCI:C39052
database_cross_reference: NCI_BioC:C39052

PDGF Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Platelet Derived Growth Factor (PDGF) plays a critical role in cellular proliferation and development. The biologically active form is a dimer formed from the A and B chains. PDGF is active to a differing degree depending on which dimer is formed (AA, AB, or BB). The PDGF Receptor (PDGFR) is also a dimer and can form from the combination of the alpha and beta chains in any order (alpha-alpha, alpha-beta, beta-beta). The PDGFR dimer is only formed after ligand binding so the alpha/beta composition of the receptor can be influenced by the form of PDGF that is present. Upon binding of ligand the PDGFR is tyrosine phosphorylated and leads to the phosphorylation of several other cellular proteins. (This definition may be outdated - see the DesignNote.)
MCID: MC00527338
PMOID: PMO:00015059
Subclass_of: Signaling Pathway
Tree Number: T4.9.130
database_cross_reference: NCI:C39184
database_cross_reference: NCI_BioC:C39184

PDGFR-alpha Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00815379
PMOID: PMO:00015060
Subclass_of: Signaling Pathway
Synonym: Alpha-Type Platelet-Derived Growth Factor Receptor Signaling Pathway
Synonym: PDGFR-alpha signaling pathway
Tree Number: T4.9.131
database_cross_reference: GO:GO:0035790
database_cross_reference: NCI:C91647
database_cross_reference: NCI_PID:C91647

PDGFR-beta Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00815380
PMOID: PMO:00015061
Subclass_of: Signaling Pathway
Synonym: Beta-Type Platelet-Derived Growth Factor Receptor Signaling Pathway
Synonym: PDGF receptor-beta signaling pathway
Synonym: PDGFR-beta signaling pathway
Synonym: betaPDGF receptor signaling pathway
Synonym: platelet-derived growth factor receptor-beta signaling pathway
Synonym: platelet-derived growth factor receptor-beta signalling pathway
Tree Number: T4.9.132
database_cross_reference: GO:GO:0035791
database_cross_reference: NCI:C91648
database_cross_reference: NCI_PID:C91648

Pelp1 Estrogen Receptor Pathway
type: Class
subclass of: Signaling Pathway
Definition: Proline-, glutamic acid-, leucine-rich protein 1 (Pelp1 or modulator of nongenomic activity of estrogen, MNAR) is a recently discovered transmitter of estrogen signals. The receptors for estrogen (ER), progestin (PR), androgen (AR) and others are steroid hormone receptors, which are part of a large family of ligand-inducible transcription factors. It has been established that estrogen has at least two courses of action termed classical or genomic and nongenomic. The classical activation cascade is well known. The nongenomic or nontranscriptional activation cascade for the estrogen receptor was determined based on the rapid response times observed for the activation of the MAPK cascade and other cell proliferation effects. The mechanism was believed to involve a membrane bound ER but attempts to isolate such a protein have not been successful. A second possibility would involve a scaffold protein that interacts with ER. Pelp1 appears to fit the second scenario. Pelp1 was first isolated as a coactivator of transcription for ER-alpha. It was observed that Pelp1 was expressed at levels 3-5 times normal in breast tumors. Several breast cancer cell lines have been shown to express Pelp1. Like many nuclear hormone receptors Pelp1 also interacts with Cbp and p300. More recently it has been demonstrated that Pelp1 mediates the interaction of ER and Src leading to the activation of the Mitogen Activated Protein Kinases Erk1 and Erk2. (This definition may be outdated - see the DesignNote.)
MCID: MC00527414
PMOID: PMO:00015062
Subclass_of: Signaling Pathway
Synonym: Pelp1 Modulation of Estrogen Receptor Activity
Tree Number: T4.9.133
database_cross_reference: NCI:C39186
database_cross_reference: NCI_BioC:C39186

Phosphatidylinositol Signaling System Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00527466
PMOID: PMO:00015063
Subclass_of: Signaling Pathway
Synonym: Phosphatidylinositol Signaling System
Tree Number: T4.9.134
database_cross_reference: NCI:C38850
database_cross_reference: NCI_KEGG:C38850

Phospholipase C Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Phospholipase C comes in multiple forms and plays a key role in the signal transduction process for many receptors. Its main function is to hydrolyze phosphatidylinositol diphosphate into diacylglycerol (DG) and inositol triphosphate (IP3). DG is necessary for further activation of Protein Kinase C while IP3 leads to the release of intracellular calcium. (This definition may be outdated - see the DesignNote.)
MCID: MC00527469
PMOID: PMO:00015064
Subclass_of: Signaling Pathway
Tree Number: T4.9.135
database_cross_reference: NCI:C39194
database_cross_reference: NCI_BioC:C39194

Phospholipase C-Epsilon Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Proposed model for b2-AR- and prostanoid-receptor-mediated PLC and calcium signaling. Receptors coupling to Gs stimulate AC, resulting in elevated cAMP levels and activation of Epac1. Epac1 then catalyses GTP-loading on Rap2B, which leads to PLC-e activation. The proposed pathway may involve additional signaling components to attain PLC stimulation. The action of cAMP seems to be independent of PKA; instead, the cAMP-activated Rap-GEF Epac seems to serve as a cAMP effector, inducing GTP loading and, hence, activation of Rap2B, which then leads to specific activation of PLC-e, which has been shown to interact with Rap GTPases. It is an attractive hypothesis, therefore, that the Rap-dependent PLC and calcium signaling pathway reported here is not restricted to Gs-and AC-coupled receptors, such as the b2-AR and the prostanoid receptor, but could be used by other receptors as well. (This definition may be outdated - see the DesignNote.)
MCID: MC00527468
PMOID: PMO:00015065
Subclass_of: Signaling Pathway
Synonym: Phospholipase C-epsilon pathway
Tree Number: T4.9.136
database_cross_reference: NCI:C39193
database_cross_reference: NCI_BioC:C39193

Phospholipid Associated Cell Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Phospholipase C (PLC) d1 is a member of the PLC family that produces two second messengers, diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) by hydrolyzing the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). DAG in combination with Ca++ is necessary for further activation of Protein Kinase C, while IP3 diffuses into the cytoplasm and mediates the release of intracellular calcium. PLC d1 has a pleckstrin homology (PH) domain that binds to PIP2 in the membrane with an affinity of 1.7 mM. It has selectivity for PIP2 over other phosphatidylinositol lipids and provides a specific probe for activation of PIP2 metabolism to DG and IP3. Activation of PLC d1 results in its translocation from the membrane to the cytoplasm. PLC d1 activity is feedback-inhibited by IP3, which has an 8-fold higher affinity for PLC d1 than does PIP2. The members of the PLC family play a key role in the signal transduction cascade for many receptors. At basal Ca++ levels PLC d1 has been shown to be activated by the adrenoreceptor a1B, adrenoreceptor a1D, a-thromboxane receptor and oxytocin receptor. The G protein involved is the GTP-binding protein known as tissue transglutaminase (Gah or TGII). Gah is a bifunctional enzyme, having GTPase and transglutaminase (TGase) activity and is present in the plasma membrane, cytosol, and nucleus. Exchange of GDP to GTP by Gah is facilitated by activation of the receptors. However, a bimodal regulation of PLC d1 activity has been observed depending on Ca++ levels and occupancy of the guanine nucleotide binding site of Gah. In addition, the GTPase activating protein RhoGAP interacts with and stimulates PLC d1. The complex regulation of PLC d1 activity enables the protein to modulate intracellular signaling. (This definition may be outdated - see the DesignNote.)
MCID: MC00527470
PMOID: PMO:00015066
Subclass_of: Signaling Pathway
Synonym: Phospholipase C d1 in phospholipid associated cell signaling
Tree Number: T4.9.137
database_cross_reference: NCI:C39192
database_cross_reference: NCI_BioC:C39192

Phospholipid Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Sphingosine-1-phosphate (S1P) is an example of a lipid messenger with both intracellular and extracellular functions. Intracellularly S1P regulates proliferation and survival; extracellularly S1P is a ligand for EDG1 (also known as S1P1). Activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine, increases cellular levels of S1P. Inhibitors of SPHK block formation of S1P and inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (PDGF) and PMA. In a study using endothelial cells it was demonstrated that S1P induces activation of alpha-v and B3 integrins via RhoA. S1P also activates Akt via Gi and PI3K. The activated Akt phosphorylates the Edg1 receptor on threonine 236 leading to the activation of Rac1 and subsequent signals leading to actin assembly, chemotaxis and lamellipodia formation. Edg1 stimulation also leads to the activation of the ERK signaling cascade resulting in anti-apoptotic reversal, proliferation and cell survival. (This definition may be outdated - see the DesignNote.)
MCID: MC00527472
PMOID: PMO:00015067
Subclass_of: Signaling Pathway
Synonym: Phospholipids as signaling intermediaries
Tree Number: T4.9.138
database_cross_reference: NCI:C39055
database_cross_reference: NCI_BioC:C39055

Phototransduction Pathway
type: Class
subclass of: Signaling Pathway
Definition: Phototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons by the photoreceptive pigments, the rhodopsins, which consist of a membrane embedded chromophore, 11-cis-retinal, and a G-protein-coupled receptor, opsin. The photon isomerizes 11-cis-retinal to all-trans-retinal which induces a structural change that activates the opsin. This triggers hydrolysis of cGMP by activating a transducin-phosphodiesterase 6 (PDE6) cascade, which results in closure of the cGMP-gated cation channels (CNG) in the plasma membrane and membrane hyperpolarization. The hyperpolarization of the membrane potential of the photoreceptor cell modulates the release of neurotransmitters to downstream cells. Recovery from light involves the deactivation of the light-activated intermediates: photolyzed rhodopsin is phosphorylated by rhodopsin kinase (RK) and subsequently capped off by arrestin; GTP-binding transducin alpha subunit deactivates through a process that is stimulated by RGS9.
MCID: MC01393751
PMOID: PMO:00015068
Subclass_of: Signaling Pathway
Synonym: Phototransduction
Tree Number: T4.9.139
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91805
database_cross_reference: NCI_KEGG:C91805

Plasma Membrane Estrogen Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393752
PMOID: PMO:00015069
Subclass_of: Signaling Pathway
Synonym: Plasma membrane estrogen receptor signaling
Tree Number: T4.9.140
database_cross_reference: NCI:C91649
database_cross_reference: NCI_PID:C91649

PPAR Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
MCID: MC00761768
PMOID: PMO:00015070
Subclass_of: Signaling Pathway
Synonym: PPAR signaling pathway
Synonym: Peroxisome Proliferator-Activated Receptor Signaling Pathway
Synonym: peroxisome proliferator activated receptor signaling pathway
Synonym: peroxisome proliferator activated receptor signalling pathway
Synonym: peroxisome proliferator-activated receptor signaling pathway
Tree Number: T4.9.141
database_cross_reference: GO:GO:0035357
database_cross_reference: NCI:C91497
database_cross_reference: NCI_KEGG:C91497

Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394221
PMOID: PMO:00015071
Subclass_of: Signaling Pathway
Synonym: Signaling events regulated by Ret tyrosine kinase
Tree Number: T4.9.142
database_cross_reference: NCI:C91681
database_cross_reference: NCI_PID:C91681

PTP4A Family Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394202
PMOID: PMO:00015072
Subclass_of: Signaling Pathway
Synonym: PRL Signaling Pathway
Synonym: Signaling events mediated by PRL
Tree Number: T4.9.143
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91677
database_cross_reference: NCI_PID:C91677

PTPN1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394171
PMOID: PMO:00015073
Subclass_of: Signaling Pathway
Synonym: PTP1B Signaling Pathway
Synonym: Signaling events mediated by PTP1B
Tree Number: T4.9.144
database_cross_reference: NCI:C91678
database_cross_reference: NCI_PID:C91678

Pyk2 and Map Kinase Pathway
type: Class
subclass of: Signaling Pathway
Definition: This pathway is a compilation of Pyk2 effort cascades; in specific cell types the receptor and effectors will vary. Binding of a transmembrane receptor triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatives the JNK cascade, starting with PAK followed by MEKK1, SEK1, and JNK. JNK activation causes induction of c-Jun gene binding. Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38. The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2. (This definition may be outdated - see the DesignNote.)
MCID: MC00525051
PMOID: PMO:00015074
Subclass_of: Signaling Pathway
Synonym: Links between Pyk2 and Map Kinases
Tree Number: T4.9.145
database_cross_reference: NCI:C39206
database_cross_reference: NCI_BioC:C39206

Rac1 Cell Motility Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Rac-1 is a small G-protein in the Rho family that regulates cell motility in response to extracellular signals. Several changes in cytoskeletal structure and other aspects of cell structure are involved in cell motility. Rac-1 is activated by GEF factors, and repressed by GAPs. GEFs are guanine nucleotide exchange factors, including Trio and Vav. Sos-1 is involved in Ras signaling and also acts as a GEF for Rac to transduce signals between Ras and Rac. SWAP-70 is a Rac GEF that binds IP3 and transduces signals from tyrosine kinases to Rac to modulate the cytoskeleton and cause membrane ruffling. GAPs are GTPase- activating proteins. Rac stimulates the formation of actin-based structures such as filopodia and lamellipodia, while GAPs such as chimerin oppose the formation of these Rac dependent structures. Several different factors downstream of Rac act on cytoskeletal structure and other aspects of cell motility. Pak1 provides a direct link from Rac to cell motility through phosphorylation of the myosin light chain. Pak1 also phosphorylates and activates LIM kinase, which phosphorylates cofilin as one target. Cofilin stimulates actin depolymerization and changes in cell structure, and phosphorylation of cofilin by LIM kinase represses its activity. In neurons, Rac acts through the protein kinase cdk5 and p35 to phosphorylate and down regulate Pak1, increasing neuronal migration. Rac-1 also interacts with several other factors to regulate a variety of processes. Interaction of Por1 with Rac-1 is involved in membrane ruffling. WAVE is a member of the WASP family of proteins that regulate actin organization and that is involved in Rac signaling to cause membrane ruffling. Interaction of Rac-1 with MEKK1 integrates Rac signaling with pathways signaling through map kinases. (This definition may be outdated - see the DesignNote.)
MCID: MC00525089
PMOID: PMO:00015075
Subclass_of: Signaling Pathway
Synonym: Rac 1 cell motility signaling pathway
Tree Number: T4.9.146
database_cross_reference: NCI:C39208
database_cross_reference: NCI_BioC:C39208

Ras Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Ras activates many signaling cascades. Here we illustrate some of the well-characterized cascades in a generic compilation of effector molecules. The effectors mediate Ras stimulation to a diverse set of cellular signals. Many of these signals are interpreted differently depending on the cell type or microenvironment receiving the stimulus. Not all of these effectors are activated in any given cell type. The primary method of activation is to promote the translocation of the molecule to the plasma membrane where additional interactions lead to the activation of the molecule. RalGDS is a Guanine Exchange Factor (GEF) for Ral but also has other independent functions. RalGDS activates RalA/B-related small GTPases. RalBP1 is a GTPase activating protein that leads to the inhibition of the Rac and CDC42 GTPases. Ral can also interact with phospholipase D1 (PLD1) that can also be activated by RhoA. Ras stimulation of the lipid kinase activity of PI3K occurs through an interaction with the p110 catalytic subunit. PI3K phosphorylates the D3 position of phosphatidylinositides. In this example Pip2 is converted to PIP3. PIP3 stimulates the AKT/PKB kinase and several of the Rac-GEFs such as Sos1 AND Vav. AKT activation inhibits apoptosis by inhibiting the actions of Bad, Caspase 9, and AFX. AKT further hinders apoptosis by phosphorylating the IkB repressor of NFkB. Stimulus of Rac causes, among other things, the activation of NFkB. Ras also stimulates the mitogen-activated kinases ERK1/2 via the Raf1 cascade. The Erk kinases translocate to the nucleus where they phosphorylate various transcription factors such as ELK1. (This definition may be outdated - see the DesignNote.)
MCID: MC00525110
PMOID: PMO:00015076
Subclass_of: Signaling Pathway
Tree Number: T4.9.147
database_cross_reference: NCI:C39217
database_cross_reference: NCI_BioC:C39217

RB Checkpoint Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Cell cycle checkpoint controls at the G1 to S transition and the G2 to M transition prevent the cell cycle from progressing when DNA is damaged. The ATM protein kinase detects DNA damage and, in response to this, activates DNA repair factors and inhibits cell cycle progression. Two of the proteins that ATM phosphorylates in response to DNA damage are the tumor suppressor p53 and the checkpoint kinase chk1. In turn, the tumor suppressor p53 interacts with p21 to block the activity of cdk2 (cyclin dependent kinase 2) preventing passage from G1 to S phase and harmful replication of damaged DNA. One of the targets of cdk2 is the Rb gene product, another tumor suppressor. When dephosphorylated, Rb interacts with E2F transcription factors and prevents transcription of genes required for progression through the cell cycle. When phosphorylated by cell cycle dependent kinases like cdk2 and cdk4, Rb no longer interacts with E2F and the cell cycle proceeds through the G1-S checkpoint. DNA damage also regulates the G2-M phase transition by acting on the cell cycle regulator cdc2. (This definition may be outdated - see the DesignNote.)
MCID: MC00525062
PMOID: PMO:00015077
Subclass_of: Signaling Pathway
Synonym: RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
Tree Number: T4.9.148
database_cross_reference: NCI:C39218
database_cross_reference: NCI_BioC:C39218

Reelin Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
Definition: Reelin is an extracellular protein secreted by neurons. Reeler mice with a defective Reelin gene exhibit neuronal abnormalities in development. Mice that are heterozygous for the Reelin knockout have neuroanatomical and behavioral traits similar to those of schizophrenia patients, suggesting that mice with a deficiency in Reelin may provide a useful model for schizophrenia. Reelin protein may be involved in cognitive function in adults as well as playing a role in the developmental organization of neurons in the cortex. Multiple cell surface receptors transduce Reelin signaling into neurons. One class of Reelin receptor includes the VLDL receptor and the ApoER2. The intracellular adaptor Dab1 binds to the VLDL receptor and ApoER2 receptor through an NPxY motif and is involved in transmission of Reelin signals through these lipoprotein receptors. Mutation of the mDab1 gene in mice creates a phenotype identical to Reeler mice, supporting the role of this cytoplasmic factor in signaling downstream from Reelin. Another class of receptor for Reelin is the cadherin-related neuronal receptors, CNR receptors. Reelin signaling through several different CNR receptors activates the Fyn tyrosine kinases. Reelin stimulates phosphorylation of Dab1 and Dab1 appears to link Reelin signaling with tyrosine kinases. Disruption of the p35 and Cdk5 genes in mice indicates that cdk5 is also involved in the role of Reelin in neuronal development. (This definition may be outdated - see the DesignNote.)
MCID: MC00525162
PMOID: PMO:00015078
Subclass_of: Signaling Pathway
Synonym: Reelin Signaling Pathway
Tree Number: T4.9.149
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39220
database_cross_reference: NCI_BioC:C39220

Reelin Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
MCID: MC00815382
PMOID: PMO:00015079
Subclass_of: Signaling Pathway
Synonym: Reelin signaling pathway
Tree Number: T4.9.150
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91658
database_cross_reference: NCI_PID:C91658

Retinoic Acid Receptor Family-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393806
PMOID: PMO:00015080
Subclass_of: Signaling Pathway
Synonym: Retinoic acid receptors-mediated signaling
Tree Number: T4.9.151
database_cross_reference: NCI:C91665
database_cross_reference: NCI_PID:C91665

RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway
type: Class
subclass of: Retinoic Acid Receptor Family-Mediated Signaling Pathway
MCID: MC01393809
PMOID: PMO:00015081
Subclass_of: Retinoic Acid Receptor Family-Mediated Signaling Pathway
Synonym: RXR and RAR heterodimerization with other nuclear receptor
Tree Number: T4.9.151.1
database_cross_reference: NCI:C91666
database_cross_reference: NCI_PID:C91666

Rho Cell Motility Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: RhoA is a small G-protein in the Rho family that regulates cell morphology via actin cytoskeleton reorganization in response to extracellular signals. The majority of RhoA activations are due to disruption of intramolecular autoinhibitory interactions. Changes in cytoskeletal structure and other aspects of cell structure are involved in cell morphology. RhoA is activated by GEF factors, and repressed by GAPs. GEFs are guanine nucleotide exchange factors. GAPs are GTPase-activating proteins. The RhoGAP ARHGAP1 also acts as a GAP for Rac and CDC42. Active RhoA increases the stability of actin-based structures such as stress fibers and focal adhesions. Several different factors downstream of RhoA act on cytoskeletal structures to affect stability of these structures. Rock1 provides a direct link from RhoA to cell morphology through phosphorylation of the myosin light chain. Rock1 also phosphorylates and activates LIM kinase, which phosphorylates cofilin. Cofilin stimulates actin depolymerization and changes in cell structure, and phosphorylation of cofilin by LIM kinase represses this activity. According to Nimnual et al. Rho activity is reduced as a result of Rac-induced redox-dependent inhibition. (This definition may be outdated - see the DesignNote.)
MCID: MC01394117
PMOID: PMO:00015082
Subclass_of: Signaling Pathway
Synonym: Rho cell motility signaling pathway
Tree Number: T4.9.152
database_cross_reference: NCI:C39223
database_cross_reference: NCI_BioC:C39223

RIG-I-Like Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
MCID: MC01393823
PMOID: PMO:00015083
Subclass_of: Signaling Pathway
Synonym: RIG-I-like receptor signaling pathway
Tree Number: T4.9.153
database_cross_reference: NCI:C91507
database_cross_reference: NCI_KEGG:C91507

Rod Cell Visual Signal Transduction Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394112
PMOID: PMO:00015084
Subclass_of: Signaling Pathway
Synonym: Visual signal transduction: Rods
Tree Number: T4.9.154
database_cross_reference: NCI:C91699
database_cross_reference: NCI_PID:C91699

SODD/TNFR1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The tumor necrosis factor (TNF) receptor superfamily contains several members with homologous cytoplasmic domains known as death domains (DD). The intracellular DD are important in initiating apoptosis and other signaling pathways following ligand binding by the receptors. In the absence of ligand, DD-containing receptors are maintained in an inactive state. TNFR1 contains a cytoplasmic DD required for signaling pathways associated with apoptosis and NF-kB activation. Jiang et al. identified a widely expressed 60 kDa protein, named SODD (silencer of death domains), associated with the DD of TNFR1 and DR3. Overexpression of SODD suppresses TNF-induced cell death and NF-kB activation demonstrating its role as a negative regulatory protein for these signaling pathways. TNF-induced receptor trimerization aggregates the DD of TNFR1 and recruits the adapter protein TRADD. This in turn promotes the recruitment of the DD-containing cytoplasmic proteins FADD, TRAF2, and RIP to form an active TNFR1 signaling complex. In contrast, SODD acts as a silencer of TNFR1 signaling and does not interact with TRADD, FADD, or RIP. It is associated with the DD of TNFR1 and maintains TNFR1 in an inactive, monomeric state. TNF-induced aggregation of TNFR1 promotes the disruption of the SODD-TNFR1 complex. SODD does not interact with the DD of other TNF receptor superfamily members such as Fas, DR4, DR5, or TNFR2. SODD association with TNFR1 may represent a general model for the prevention of spontaneous TNF signaling by other DD-containing receptors. (This definition may be outdated - see the DesignNote.)
MCID: MC00527513
PMOID: PMO:00015085
Subclass_of: Signaling Pathway
Tree Number: T4.9.155
database_cross_reference: NCI:C39234
database_cross_reference: NCI_BioC:C39234

Sonic Hedgehog Pathway
type: Class
subclass of: Signaling Pathway
Definition: Sonic Hedgehog (Shh) is one of a family of three secreted proteins, including Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh), that play distinct and crucial roles in development. The morphogenic signal Shh provides in the developing CNS induces proliferation of neuronal precursor cells in the developing cerebellum and other tissues. Proliferative signaling by Shh is involved in the development of cancer, including specific brain and skin cancers such as basal cell carcinomas, while activation of Shh signaling in neurons may also provide a means to induce neuronal regeneration. Mitogenic Shh signaling does not appear to involve Map kinase pathways, but may involve induction of Cyclin D1 expression to maintain Rb in the hyperphosphorylated state and allow progression through the G1 phase of the cell cycle. Activation of myc may be one mechanism by which Shh induces cell cycle progression. Activation of Shh proliferative signaling occurs through binding to a receptor complex including Patched (Ptc-1) and Smoothened, a G-protein coupled receptor. Patched is an integral membrane protein with twelve transmembrane domains that acts as an inhibitor of Smoothened activation. Patched has been classified as a tumor suppressor due to its inhibition of Smoothened and the presence of inactivated Ptc-1 mutations in some cancers. One possibility is that Ptc-1, which resembles transmembrane channels, may not directly associate with Smoothened but may repress Smoothened signaling by transporting an endogenous Smoothened inhibitor across the plasma membrane into the cytoplasm. Small non-peptide agonists and antagonists of the Shh pathway have been identified and appear to act at the level of the Smoothened receptor, providing pharmacological tools to study Shh signaling. The pathway downstream of the Smoothened receptor has remained somewhat unclear, but involves the Gli family of transcriptional activators, including Gli-1, Gli-2, and Gli-3, homologs of the drosophila gene cubitis i…
MCID: MC01393693
PMOID: PMO:00015086
Subclass_of: Signaling Pathway
Synonym: Sonic Hedgehog (Shh) Pathway
Tree Number: T4.9.156
database_cross_reference: NCI:C39231
database_cross_reference: NCI_BioC:C39231

Sphingosine 1-Phosphate Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00815384
PMOID: PMO:00015087
Subclass_of: Signaling Pathway
Synonym: S1P receptor signaling pathway
Synonym: S1P signaling pathway
Synonym: S1P-activated G-protein coupled receptor signaling pathway
Synonym: S1P-activated GPCR signaling pathway
Synonym: S1P-stimulated signal transduction pathway
Synonym: Sphingosine 1-phosphate (S1P) pathway
Synonym: sphingosine-1-phosphate signal transduction
Synonym: sphingosine-1-phosphate signaling pathway
Tree Number: T4.9.157
database_cross_reference: GO:GO:0003376
database_cross_reference: NCI:C91667
database_cross_reference: NCI_PID:C91667

Sphingosine 1-Phosphate Receptor 1 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
MCID: MC01393785
PMOID: PMO:00015088
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG1 Signaling Pathway
Synonym: S1P1 pathway
Tree Number: T4.9.157.1
database_cross_reference: NCI:C91668
database_cross_reference: NCI_PID:C91668

Sphingosine 1-Phosphate Receptor 2 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
MCID: MC01394209
PMOID: PMO:00015089
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG2 Signaling Pathway
Synonym: S1P2 pathway
Tree Number: T4.9.157.2
database_cross_reference: NCI:C91669
database_cross_reference: NCI_PID:C91669

Sphingosine 1-Phosphate Receptor 3 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
MCID: MC01394180
PMOID: PMO:00015090
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG3 Signaling Pathway
Synonym: S1P3 pathway
Tree Number: T4.9.157.3
database_cross_reference: NCI:C91670
database_cross_reference: NCI_PID:C91670

Sphingosine 1-Phosphate Receptor 4 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
MCID: MC01394184
PMOID: PMO:00015091
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG4 Signaling Pathway
Synonym: S1P4 pathway
Tree Number: T4.9.157.4
database_cross_reference: NCI:C91671
database_cross_reference: NCI_PID:C91671

Sphingosine 1-Phosphate Receptor 5 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
MCID: MC01394187
PMOID: PMO:00015092
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG5 Signaling Pathway
Synonym: S1P5 pathway
Tree Number: T4.9.157.5
database_cross_reference: NCI:C91672
database_cross_reference: NCI_PID:C91672

Sprouty Regulation of Tyrosine Kinase Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors, including EGF and FGF. One mechanism by which Sprouty proteins inhibit signaling is through binding to Grb-2, a signaling intermediary between the tyrosine kinase growth factors and the Ras/map kinase pathway. Binding of Sprouty to Grb-2 prevents Grb-2 and Sos-1 from interacting with downstream signaling factors that activate Ras and map kinases, including Ras, Raf-1, Mek1, Erk1/2, and downstream transcription factors. The action of Sprouty as an inhibitor of this pathway requires Sprouty phosphorylation and membrane localization at the site of the factors it interacts with. The inhibition of growth factor signaling by Sprouty is specific to the Ras pathway since the PI3 Kinase pathway responsible for cell survival signals from growth factor receptors is not inhibited by Sprouty. Tyrosine kinase activity of growth factor receptors is also not affected. The mechanism by which Sprouty inhibits Ras activation may be by blocking the nucleotide exchange activity of Sos. Sprouty expression is induced by growth factor receptor activation of Ras signaling, provided a self-regulatory feedback inhibition mechanism that regulates growth factor signaling through Ras. In addition to blocking the Ras pathway, Sprouty also induces protein tyrosine phosphatase 1B activity. Activation of PTP1B by Sprouty is responsible for the inhibition of cellular migration that Sprouty causes, but is not involved in regulation of cellular proliferation. While blocking receptor tyrosine kinase signaling, at least one member of the Sprouty family, Sprouty-2, also acts by one mechanism to stimulate EGF receptor signaling. Cbl targets the EGF receptor for tagging with ubiquitin and proteolytic destruction. Sprouty-2 binds to Cbl and blocks the ubiquitination and destruction of the EGF receptor, increasing EGF signaling. (This definition may be outdated…
MCID: MC00527667
PMOID: PMO:00015093
Subclass_of: Signaling Pathway
Synonym: Sprouty regulation of tyrosine kinase signals
Tree Number: T4.9.158
database_cross_reference: NCI:C39236
database_cross_reference: NCI_BioC:C39236

Stat3 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: STATs, Signal Transducers and Activators of Transcription, are transcription factors that are phosphorylated by JAK kinases in response to cytokine activation to dimerize and move into the nucleus to activate transcription of cytokine-responsive genes. There are at least 3 JAK kinases and at least six STATs, with different cytokines inducing different patterns of JAK and STAT activation. Cytokines that activate STAT3 include growth hormone, IL-6 family cytokines, and G-CSF. STAT3, as well as STAT5, induces progression through the cell cycle, prevents apoptosis, and may be associated with cancer development in some cases. STAT3 plays an important role in normal development, particularly hematopoiesis. The importance of STAT3 is underscored by the failure of mice lacking STAT3 to survive embryogenesis. Crosstalk from pathways other than JAK kinases also leads to phosphorylation and activation of STAT3 as indicated by a role of mTOR (mammalian target of rapamycin, or p70 S6 kinase) and mitogen-activated protein kinase (MAP kinase) pathways in STAT3 activation and signaling. (This definition may be outdated - see the DesignNote.)
MCID: MC00525227
PMOID: PMO:00015094
Subclass_of: Signaling Pathway
Tree Number: T4.9.159
database_cross_reference: NCI:C39238
database_cross_reference: NCI_BioC:C39238

Stress Fiber Formation Pathway
type: Class
subclass of: Signaling Pathway
Definition: The A-kinase anchor protein 13 (AKAP13, also known as AKAP-LBC) is one of a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP13 is a splice variant of the oncogene Lbc. Alternative splicing of the AKAP13 gene results in at least 3 transcript variants encoding different isoforms containing a Dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. These splice variants contain a fragment that was originally identified as Ht31 (See Carr et al 1991) which acts as a scaffolding protein to regulate the Rho signaling pathway and as protein kinase A-anchoring protein creating a coordination of these two signaling pathways. Diviani et al. found that in HEK293 cells LPA induced stimulation preferentially activates AKAP13 via G-alpha12. As yet targets for the anchored PKA have not been identified. AKAP13 and Rho do not appear to be phosphorylated by PKA. Diviani et al also found that the Lbc oncogene and protooncogene splice variant show higher activation and stress fiber localization. This appears to be a result of the presence of N terminal inhibitory sequences. A similar model of regulation has been proposed for Dbl and Vav. (This definition may be outdated - see the DesignNote.)
MCID: MC00525244
PMOID: PMO:00015095
Subclass_of: Signaling Pathway
Synonym: Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation
Tree Number: T4.9.160
database_cross_reference: NCI:C38978
database_cross_reference: NCI_BioC:C38978

Syndecan-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01393770
PMOID: PMO:00015096
Subclass_of: Signaling Pathway
Synonym: Proteogylcan syndecan-mediated signaling events
Tree Number: T4.9.161
database_cross_reference: NCI:C91655
database_cross_reference: NCI_PID:C91655

Syndecan-1-Mediated Signaling Pathway
type: Class
subclass of: Syndecan-Mediated Signaling Pathway
MCID: MC01394240
PMOID: PMO:00015097
Subclass_of: Syndecan-Mediated Signaling Pathway
Synonym: Syndecan-1-mediated signaling events
Tree Number: T4.9.161.1
database_cross_reference: NCI:C91686
database_cross_reference: NCI_PID:C91686

Syndecan-2-Mediated Signaling Pathway
type: Class
subclass of: Syndecan-Mediated Signaling Pathway
MCID: MC01394245
PMOID: PMO:00015098
Subclass_of: Syndecan-Mediated Signaling Pathway
Synonym: Syndecan-2-mediated signaling events
Tree Number: T4.9.161.2
database_cross_reference: NCI:C91687
database_cross_reference: NCI_PID:C91687

Syndecan-3-Mediated Signaling Pathway
type: Class
subclass of: Syndecan-Mediated Signaling Pathway
MCID: MC01394249
PMOID: PMO:00015099
Subclass_of: Syndecan-Mediated Signaling Pathway
Synonym: Syndecan-3-mediated signaling events
Tree Number: T4.9.161.3
database_cross_reference: NCI:C91688
database_cross_reference: NCI_PID:C91688

Syndecan-4-Mediated Signaling Pathway
type: Class
subclass of: Syndecan-Mediated Signaling Pathway
MCID: MC01394121
PMOID: PMO:00015100
Subclass_of: Syndecan-Mediated Signaling Pathway
Synonym: Syndecan-4-mediated signaling events
Tree Number: T4.9.161.4
database_cross_reference: NCI:C91689
database_cross_reference: NCI_PID:C91689

Taste Transduction Pathway
type: Class
subclass of: Signaling Pathway
Definition: All taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na+ through the amiloride-sensitive Na+ channel (ENaC). Acids depolarize taste cells by a variety of mechanisms, including influx of protons (H+) through ENaC and a proton-gated cation channel (MDEG). Two putative umami receptors have been identified: a truncated variant of the metabotropic glutamate receptor mGluR4 and the heterodimer, T1R1 + T1R3. Umami receptors are coupled to a signaling pathway involving activation of PLCbeta2, production of IP3 and diacylglycerol, release of Ca2+ from intracellular stores and activation of a transient receptor potential channel, TRPM5. Bitter compounds, such as denatonium and PROP, activate particular T2R/TRB isoforms, which activate gustducin heterotrimers. Activated alpha-gustducin stimulates PDE to hydrolyze cAMP, whereas betagamma subunits activate PLCbeta2 to generate IP3, which leads to release of Ca2+ from internal stores. Artificial sweeteners activate GPCRs (T1R heterodimers) apparently linked via PLC to IP3 production and release of Ca2+ from intracellular stores. Sugars apparently activate GPCRs linked via AC to cAMP production which, in turn, may inhibit basolateral K+ channels through phosphorylation by cAMP-activated protein kinase A (PKA).
MCID: MC01394151
PMOID: PMO:00015101
Subclass_of: Signaling Pathway
Synonym: Taste transduction
Tree Number: T4.9.162
database_cross_reference: NCI:C91453
database_cross_reference: NCI_KEGG:C91453

TGF Beta Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
Definition: TGF-beta regulates growth and proliferation of cells, blocking growth of many cell types. The TGF-beta receptor includes type 1 and type 2 subunits that are serine-threonine kinases and that signal through the SMAD family of transcriptional regulators. Defects in TGF-beta signaling, including mutation in SMADs, have been associated with cancer in humans. Prior to activation, receptor regulated SMADs are anchored to the cell membrane by factors like SARA (SMAD Anchor for Receptor Activation) that brings the SMADs into proximity of the TGF receptor kinases. Binding of TGF induces phosphorylation and activation of the TGF-beta R1 receptor by the TGF-beta R2 receptor. The activated TGF-beta R1 phosphorylates SMAD2 and SMAD3, which bind to the SMAD4 mediator to move into the nucleus and form complexes that regulate transcription. SMADs regulate transcription in several ways, including binding to DNA, interacting with other transcription factors, and interacting with transcription corepressors and coactivators like p300 and CBP. SMAD-7 represses signaling by other SMADs to down-regulate the system. Other signaling pathways, like the MAP kinase-ERK cascade activated by TGF-beta signaling, modulate SMAD activation. SnoN also regulates TGF-beta signaling, by binding to SMADs to block transcriptional activation. TGF-beta signaling causes degradation of SnoN, releasing SMADs to regulate transcription, and also activates expression of SnoN, to down-regulate SMAD signaling at later times. (This definition may be outdated - see the DesignNote.)
MCID: MC01393992
PMOID: PMO:00015102
Subclass_of: Signaling Pathway
Synonym: TGF beta signaling pathway
Tree Number: T4.9.163
database_cross_reference: NCI:C39251
database_cross_reference: NCI_BioC:C39251

TGF-Beta Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00388912
PMOID: PMO:00015103
Subclass_of: Signaling Pathway
Synonym: TGF-beta receptor signaling
Synonym: TGF-beta receptor signaling pathway
Synonym: TGF-beta receptor signalling pathway
Synonym: TGFbeta receptor signaling pathway
Synonym: TGFbeta receptor signalling pathway
Synonym: Tumor Growth Factor-Beta Receptor Signaling Pathway
Synonym: transforming growth factor beta receptor signaling pathway
Synonym: transforming growth factor beta receptor signalling pathway
Tree Number: T4.9.164
database_cross_reference: GO:GO:0007179
database_cross_reference: NCI:C91690
database_cross_reference: NCI_PID:C91690

TGF-beta Signaling Pathway KEGG
type: Class
subclass of: Signaling Pathway
Definition: The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads (R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
MCID: MC01393862
PMOID: PMO:00015104
Subclass_of: Signaling Pathway
Synonym: TGF-beta signaling pathway
Tree Number: T4.9.165
database_cross_reference: NCI:C91522
database_cross_reference: NCI_KEGG:C91522

Thrombin/Protease-Activated Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Thrombin is an extracellular protease that is involved in the clotting of blood and inflammation through its action on platelets and endothelial cells in the vasculature and that plays a role in thrombosis and myocardial infarction. The protease activated receptors PAR1 and PAR4 are cellular targets of thrombin signaling and members of the G-protein coupled receptor gene family. Both of these receptors are cleaved in their N-terminus by thrombin, unmasking a portion of the receptor sequence that acts itself as a tethered peptide ligand that activates the receptor. The tethered ligand that activates PAR1 is SFLLRN and the tethered ligand that activates PAR4 is GYPGQV. Other members of the family include PAR2 which is activated by trypsin rather than thrombin and PAR3 which seems to play a role in the activation of other PARs but does not itself transduce a signal directly. Addition of peptide agonist exogenously in solution can also activate PAR1, PAR2 and PAR4. PAR1 activation may be involved in the dilation of arteries during inflammation through the action of thrombin on endothelial cells and in platelet activation by thrombin during clotting. PAR1 and PAR2 activation cause bronchodilation in airway and may protect against asthma. PAR 4 activation by thrombin activates platelets during clotting and mice lacking PAR4 have impaired clotting and platelets that do not respond to thrombin signaling. The action of thrombin on PAR1 and PAR4 on platelets and endothelial cells may also contribute to vascular permeability and inflammation. Activated PARs appear to couple primarily through Gq-mediated stimulation of inositol phosphate metabolism and intracellular calcium levels to activate platelets. PAR1 and PAR4 also appear to couple to multiple G-proteins and transduce signals through more than one G-protein mediated pathway in some circumstances. Signaling by PAR1 and PAR4 through Galpha12 pathways couples to Rho signaling and changes in cytoskeletal structure and cell s…
MCID: MC01394035
PMOID: PMO:00015105
Subclass_of: Signaling Pathway
Synonym: Thrombin signaling and protease-activated receptors
Tree Number: T4.9.166
database_cross_reference: NCI:C39278
database_cross_reference: NCI_BioC:C39278

Thromboxane A2 Receptor Family Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394123
PMOID: PMO:00015106
Subclass_of: Signaling Pathway
Synonym: Thromboxane A2 receptor signaling
Tree Number: T4.9.167
database_cross_reference: NCI:C91691
database_cross_reference: NCI_PID:C91691

TNF Receptor Family Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394127
PMOID: PMO:00015107
Subclass_of: Signaling Pathway
Synonym: TNF receptor signaling pathway
Synonym: Tumor Necrosis Factor Receptor Signaling Pathway
Tree Number: T4.9.168
database_cross_reference: NCI:C91692
database_cross_reference: NCI_PID:C91692

TNF Stress Related Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: TNF acts on several different signaling pathways through two cell surface receptors, TNFR1 and TNFR2 to regulate apoptotic pathways, NF-kB activation of inflammation, and activate stress-activated protein kinases (SAPKs). Interaction of TNFR1 with TRADD leads to activation of NF-kB and apoptosis pathways, while interaction with TRAF2 has generally been thought to be involved in stress kinase and NF-kB activation but is not required for TNF to induce apoptosis. Activation of NF-kB is mediated by TRAF2 through the NIK kinase and also by RIP but the observation that TNF activates NF-kB in mice lacking TRAF2 indicates that TRAF-2 does not play an essential role in this process. Stress-activated protein kinases, also called JNKs, are a family of map kinases activated by cellular stress and inflammatory signals. Binding of TNF to the TNFR1 receptor activates the germinal center kinase (GCK) through the TNF adaptor Traf2, activating the map kinase MEKK1. Both GCK and MEKK1 interact with Traf2, and GCK is required for MEKK1 activation by TNF, but GCK kinase activity does not appear to be required for MEKK1 activation. Instead, GCK activates MEKK1 by causing MEKK1 oligomerization and autophosphorylation. Tank increases the affinity of Traf2 for GCK to increase Map kinase activation by TNF. Once activated, MEKK1 stands at the top of a map kinase pathway leading to transcriptional regulation, including JNK phosphorylation of c-Jun to stimulate transcriptional activation by AP-1, a heterodimer of c-jun and fos or ATF proteins. The activation of the p38 Map kinase also contributes to AP-1 activation leading to the transcriptional activation of many stress and growth related genes. RIP has been suggested as a component of the p38 pathway in addition to playing a role in NF-kB activation. MEKK1 knockout mice support the role of MEKK1 in JNK activation in some cells but did not support MEKK1 dependent activation of NF-kB. Alternative redundant mechanisms may obscure the role of MEK…
MCID: MC00525344
PMOID: PMO:00015108
Subclass_of: Signaling Pathway
Synonym: TNF/Stress Related Signaling
Tree Number: T4.9.169
database_cross_reference: NCI:C39241
database_cross_reference: NCI_BioC:C39241

TNFR1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: TNFR1 (p55, CD120a) is the receptor for TNF-alpha and also will bind TNF-beta. Upon binding TNF-alpha a TNFR1+ cell is triggered to undergo apoptosis. This critical regulatory process is accomplished by activating the proteolytic caspase cascade that results in the degradation of many critical cellular proteins. (This definition may be outdated - see the DesignNote.)
MCID: MC00525342
PMOID: PMO:00015109
Subclass_of: Signaling Pathway
Tree Number: T4.9.170
database_cross_reference: NCI:C39254
database_cross_reference: NCI_BioC:C39254

TNFR2 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: TNFR2 is the receptor for the 171 amino acid 19 kD TNF-beta (a.k.a. lymphotoxin). TNF-beta is produced by activated lymphocytes and can be cytotoxic to many tumor and other cells. In neutrophils, endothelial cells and osteoclasts TNF-beta can lead to activation while in many other cell types it can lead to increased expression of MHC and adhesion molecules. (This definition may be outdated - see the DesignNote.)
MCID: MC00525343
PMOID: PMO:00015110
Subclass_of: Signaling Pathway
Tree Number: T4.9.171
database_cross_reference: NCI:C39255
database_cross_reference: NCI_BioC:C39255

Toll-Like Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-kappa B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-kappa B and MAPK.
MCID: MC00594112
PMOID: PMO:00015111
Subclass_of: Signaling Pathway
Synonym: TLR signaling pathway
Synonym: Toll-like receptor signaling pathway
Synonym: toll-like receptor signaling pathway
Synonym: toll-like receptor signalling pathway
Tree Number: T4.9.172
database_cross_reference: GO:GO:0002224
database_cross_reference: NCI:C91505
database_cross_reference: NCI_KEGG:C91505

TPO Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several major pathways including MAPK (ERK and JNK), Protein Kinase C, and JAK/Stat. (This definition may be outdated - see the DesignNote.)
MCID: MC00525349
PMOID: PMO:00015112
Subclass_of: Signaling Pathway
Tree Number: T4.9.173
database_cross_reference: NCI:C39258
database_cross_reference: NCI_BioC:C39258

TRAIL Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC01394091
PMOID: PMO:00015113
Subclass_of: Signaling Pathway
Synonym: TRAIL signaling pathway
Tree Number: T4.9.174
database_cross_reference: NCI:C91693
database_cross_reference: NCI_PID:C91693

Trka Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine kinase receptors that also includes TrkB and TrkC. Some NGF responses are also mediated or modified by p75LNTR, a low affinity neurotrophin receptor. Binding of NGF to TrkA stimulates neuronal survival, and also proliferation. Pathways coupled to these responses are linked to TrkA through association of signaling factors with specific amino acids in the TrkA cytoplasmic domain. Cell survival through inhibition of apoptosis is signaled through activation of PI3-kinase and AKT. Ras-mediated signaling and phospholipase C both activate the MAP kinase pathway to stimulate proliferation. (This definition may be outdated - see the DesignNote.)
MCID: MC00527730
PMOID: PMO:00015114
Subclass_of: Signaling Pathway
Tree Number: T4.9.175
database_cross_reference: NCI:C39259
database_cross_reference: NCI_BioC:C39259

Tubby Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: The tubby gene product is expressed in the brain and has been implicated by mouse genetics in obesity and other disorders such as blindness. Structural analysis predicts that this gene acts as a transcription factor, binding to DNA to regulate gene expression. More recently, it was reported that tubby binds to phosphoinositides in the plasma membrane, helping to localize this factor in the membrane region in the absence of pathway activation. Tubby also interacts with Gq-alpha g-protein subunits, localizing tubby to regions of g-protein activation. Activation of phosphatase C activity and hydrolysis of membrane phosphoinositides leads to release of tubby from the plasma membrane, allowing tubby to enter the nucleus to bind DNA and regulate transcription. Some G-protein coupled receptors such as 5-HT2c may signal in part through tubby in addition to calcium-mediated pathways and protein-kinase signaling pathways. The identity of genes regulated by tubby and the mechanism by which tubby affects obesity remain to be explored. (This definition may be outdated - see the DesignNote.)
MCID: MC00527735
PMOID: PMO:00015115
Subclass_of: Signaling Pathway
Synonym: G-Protein Signaling Through Tubby Proteins
Tree Number: T4.9.176
database_cross_reference: NCI:C39261
database_cross_reference: NCI_BioC:C39261

VEGF Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma-PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3'-kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
MCID: MC01393863
PMOID: PMO:00015116
Subclass_of: Signaling Pathway
Synonym: VEGF signaling pathway
Tree Number: T4.9.177
database_cross_reference: NCI:C91524
database_cross_reference: NCI_KEGG:C91524

VEGFR1 and VEGFR2 Signaling
type: Class
subclass of: Signaling Pathway
MCID: MC01394253
PMOID: PMO:00015117
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by VEGFR1 and VEGFR2
Tree Number: T4.9.178
database_cross_reference: NCI:C91680
database_cross_reference: NCI_PID:C91680

VEGFR1 Signaling Pathway
type: Class
subclass of: VEGFR1 and VEGFR2 Signaling
MCID: MC00815387
PMOID: PMO:00015118
Subclass_of: VEGFR1 and VEGFR2 Signaling
Synonym: FLT1 Signaling Pathway
Synonym: FLT1 signaling pathway
Synonym: VEGFR-1 signaling pathway
Synonym: VEGFR1 signaling pathway
Synonym: VEGFR1 specific signals
Synonym: Vascular Endothelial Growth Factor Receptor 1 Signaling Pathway
Synonym: vascular endothelial growth factor receptor-1 signaling pathway
Tree Number: T4.9.178.1
database_cross_reference: GO:GO:0036323
database_cross_reference: NCI:C91696
database_cross_reference: NCI_PID:C91696

VEGFR3 Lymphatic Signaling Pathway
type: Class
subclass of: Signaling Pathway
MCID: MC00815388
PMOID: PMO:00015119
Subclass_of: Signaling Pathway
Synonym: FLT4 Signaling Pathway
Synonym: FLT4 signaling pathway
Synonym: VEGFR-3 signaling pathway
Synonym: VEGFR3 signaling in lymphatic endothelium
Synonym: VEGFR3 signaling pathway
Synonym: Vascular Endothelial Growth Factor Receptor 3 Signaling Pathway
Synonym: vascular endothelial growth factor receptor-3 signaling pathway
Tree Number: T4.9.179
database_cross_reference: GO:GO:0036325
database_cross_reference: NCI:C91697
database_cross_reference: NCI_PID:C91697

Visual Signal Transduction Pathway
type: Class
subclass of: Signaling Pathway
Definition: The signal transduction cascade responsible for sensing light in vertebrates is one of the best studied signal transduction processes, and is initiated by rhodopsin in rod cells, a member of the G-protein coupled receptor gene family. Rhodopsin remains the only GPCR whose structure has been resolved at high resolution. Rhodopsin in the discs of rod cells contains a bound 11-cis retinal chromophore, a small molecule derived from Vitamin A that acts as the light sensitive portion of the receptor molecule, absorbing light to initiate the signal transduction cascade. When light strikes 11-cis retinal and is absorbed, it isomerizes to all-trans retinal, changing the shape of the molecule and the receptor it is bound to. This change in rhodopsin's shape alters its interaction with transducin, the member of the G-protein gene family that is specific in its role in visual signal transduction. Activation of transducin causes its alpha subunit to dissociate from the trimer and exchange bound GDP for GTP, activating in turn a membrane-bound cyclic-GMP specific phosphodiesterase that hydrolyzes cGMP. In the resting rod cell, high levels of cGMP associate with a cyclic-GMP gated sodium channel in the plasma membrane, keeping the channels open and the membrane of the resting rod cells depolarized. This is distinct from synaptic generation of action potentials, in which stimulation induces opening of sodium channels and depolarization. When cGMP gated channels in rod cells open, both sodium and calcium ions enter the cell, hyperpolarizing the membrane and initiating the electrochemical impulse responsible for conveying the signal from the sensory neuron to the CNS. The rod cell in the resting state releases high levels of the inhibitory neurotransmitter glutamate, while the release of glutamate is repressed by the hyperpolarization in the presence of light to trigger a downstream action potential by ganglion cells that convey signals to the brain. The calcium which enters the cell…
MCID: MC00527942
PMOID: PMO:00015120
Subclass_of: Signaling Pathway
Synonym: Visual Signal Transduction
Tree Number: T4.9.180
database_cross_reference: NCI:C39222
database_cross_reference: NCI_BioC:C39222

WNT Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
Definition: Wnt family members are secreted glycoproteins that bind to cell surface receptors such as Frizzled. Wnt members can play a role in the expression of many genes by interacting with multiple disparate signaling pathways. (This definition may be outdated - see the DesignNote.)
MCID: MC00528008
PMOID: PMO:00015121
Subclass_of: Signaling Pathway
Synonym: Pathway, Wnt
Synonym: Pathway, Wnt Signaling
Synonym: Pathways, Wnt
Synonym: Pathways, Wnt Signaling
Synonym: Signaling Pathway, Wnt
Synonym: Signaling Pathways, Wnt
Synonym: WNT Signaling Pathway
Synonym: Wg signaling pathway
Synonym: Wg signalling pathway
Synonym: Wingless signaling pathway
Tree Number: T4.9.181
database_cross_reference: GO:GO:0016055
database_cross_reference: MSH:D060449
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39270
database_cross_reference: NCI_BioC:C39270

Wnt Signaling Pathway KEGG
type: Class
subclass of: Signaling Pathway
Definition: Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
MCID: MC00815372
PMOID: PMO:00015122
Subclass_of: Signaling Pathway
Synonym: Wnt signaling pathway
Tree Number: T4.9.182
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91531
database_cross_reference: NCI_KEGG:C91531

Wnt Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
MCID: MC01394174
PMOID: PMO:00015123
Subclass_of: Signaling Pathway
Synonym: Wnt signaling network
Tree Number: T4.9.183
database_cross_reference: NCI:C91555
database_cross_reference: NCI_PID:C91555

Canonical Wnt Signaling Pathway
type: Class
subclass of: Wnt Signaling Pathway PID
MCID: MC00696187
PMOID: PMO:00015124
Subclass_of: Wnt Signaling Pathway PID
Synonym: Canonical Wnt signaling pathway
Synonym: Wnt receptor signaling pathway through beta-catenin
Synonym: Wnt receptor signaling pathway via beta-catenin
Synonym: Wnt receptor signalling pathway through beta-catenin
Synonym: canonical Wnt receptor signaling pathway
Synonym: canonical Wnt signaling pathway
Synonym: canonical Wnt-activated signaling pathway
Tree Number: T4.9.183.1
database_cross_reference: GO:GO:0060070
database_cross_reference: NCI:C91559
database_cross_reference: NCI_PID:C91559

Noncanonical Wnt Signaling Pathway
type: Class
subclass of: Wnt Signaling Pathway PID
MCID: MC01393869
PMOID: PMO:00015125
Subclass_of: Wnt Signaling Pathway PID
Synonym: Noncanonical Wnt signaling pathway
Tree Number: T4.9.183.2
database_cross_reference: NCI:C91639
database_cross_reference: NCI_PID:C91639

Presenilin Action in Notch and Wnt Signaling Pathways
type: Class
subclass of: Wnt Signaling Pathway PID
MCID: MC00815381
PMOID: PMO:00015126
Subclass_of: Wnt Signaling Pathway PID
Synonym: Presenilin action in Notch and Wnt signaling
Tree Number: T4.9.183.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91654
database_cross_reference: NCI_PID:C91654

Wnt/LRP6 Signaling Pathway
type: Class
subclass of: Signaling Pathway
Definition: Wnt glycoproteins play a role in diverse processes during embryonic patterning in metazoa through interaction with frizzled-type seven-transmembrane-domain receptors (Frz) to stabilize b-catenin. LDL-receptor-related protein 6 (LRP6), a Wnt co-receptor, is required for this interaction. Dikkopf (dkk) proteins are both positive and negative modulators of this signaling. (This definition may be outdated - see the DesignNote.)
MCID: MC00528028
PMOID: PMO:00015127
Subclass_of: Signaling Pathway
Synonym: Wnt/LRP6 Signaling
Tree Number: T4.9.184
database_cross_reference: NCI:C39269
database_cross_reference: NCI_BioC:C39269

Wound Repair Pathway
type: Class
subclass of: Signaling Pathway
Definition: This pathway illustrates the opposing effects that Proepithelin (PEPI) and the elastase digest fragments, the epithelins (EPIa-g), have on epithelial growth and neutrophil activation. PEPI (also known as progranulin, PC-cell derived growth factor, and acrogranin) is comprised of seven full and one half EPI motif separated by a linker. NMR studies indicate that EPIs are compact globular structures leading to the current suggestion of a string of beads. The epithelins are highly homologous 6kDa peptides with significant conservation in plants, insects, worms and mammals. The EPIs stimulate epithelial cell secretion of IL-8, which in turn stimulates neutrophils to secrete elastase. PEPI also inhibits the inhibition of secretory leukocyte protease inhibitor (SLPI) and stimulates the growth of epithelial cells leading to wound closure. SLPI is secreted by epithelial cell, neutrophils and macrophages. SLPI inhibits elastase and cathepsinG and the inhibition of SLPI from free radicals produced by neutrophils in the blood stream as part of the balance between wound repair and wound cleaning. SLPI binds to PEPI and prevents elastase from cleaving the various linker regions between the EPIs. SLPI also binds and blocks the protease activities of elastase. Unchecked elastase leads to impaired wound healing. In summary PEPI and SLPI, normally prevalent epithelial cells, protect the epithelia from roving neutrophils. Injury causes a reduction in SLPI leading to the cleavage of PEPI into the individual EPIs. The individual EPIs activate the neutrophils and generate the wound cleaning response. As the level of SLPI returns the amount of PEPI is restored and the switch from inflammation to repair occurs. (This definition may be outdated - see the DesignNote.)
MCID: MC00528030
PMOID: PMO:00015128
Subclass_of: Signaling Pathway
Synonym: Proepithelin Conversion to Epithelin and Wound Repair Control
Tree Number: T4.9.185
database_cross_reference: NCI:C39187
database_cross_reference: NCI_BioC:C39187

Biologic Function
type: Class
subclass of: Thing
PMOID: PMO:00015129
Subclass_of: owl:Thing
Tree Number: T5

Physiologic Function
type: Class
subclass of: Biologic Function
PMOID: PMO:00015130
Subclass_of: Biologic Function
Tree Number: T5.1

Organism Function
type: Class
subclass of: Physiologic Function
PMOID: PMO:00015131
Subclass_of: Physiologic Function
Tree Number: T5.1.1

Organ or Tissue Function
type: Class
subclass of: Physiologic Function
PMOID: PMO:00015132
Subclass_of: Physiologic Function
Tree Number: T5.1.2

Cell Function
type: Class
subclass of: Physiologic Function
MCID: MC00002450
PMOID: PMO:00015133
Subclass_of: Physiologic Function
Synonym: CELL PHYSIOL
Synonym: Cell Physiological Phenomena
Synonym: Cell Physiological Phenomenon
Synonym: Cell Physiology
Synonym: Cell Process
Synonym: Cell physiology
Synonym: Cellular Function
Synonym: Cellular Physiology
Synonym: Cellular Process
Synonym: PHYSIOL CELL
Tree Number: T5.1.3
database_cross_reference: AOD:0000002339
database_cross_reference: CHV:0000002597
database_cross_reference: LCH_NW:sh85021662
database_cross_reference: MSH:D002468
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16405
database_cross_reference: NCI:C17710
database_cross_reference: NCI:C20480

Molecular Function
type: Class
subclass of: Physiologic Function
MCID: MC00383177
PMOID: PMO:00015134
Subclass_of: Physiologic Function
Synonym: molecular function
Synonym: molecular_function
Tree Number: T5.1.4
database_cross_reference: GO:GO:0003674

Genetic Function
type: Class
subclass of: Molecular Function
PMOID: PMO:00015135
Subclass_of: Molecular Function
Tree Number: T5.1.4.1

Pathologic Function
type: Class
subclass of: Biologic Function
PMOID: PMO:00015136
Subclass_of: Biologic Function
Tree Number: T5.2

Cell or Molecular Dysfunction
type: Class
subclass of: Pathologic Function
PMOID: PMO:00015140
Subclass_of: Pathologic Function
Tree Number: T5.2.2

Chemical and Drug
type: Class
subclass of: Thing
subclass of: Restriction
  on property: regulation
  some values from: PMO:00025081
subclass of: Restriction
  on property: binding regulation
  some values from: PMO:00025081
subclass of: Restriction
  on property: activation regulation
  some values from: PMO:00025081
subclass of: Restriction
  on property: degradation regulation
  some values from: PMO:00025081
subclass of: Restriction
  on property: stabilization regulation
  some values from: PMO:00025081
subclass of: Restriction
  on property: ubiquitination regulation
  some values from: PMO:00025081
subclass of: Restriction
  on property: acetylation regulation
  some values from: PMO:00025081
subclass of: Restriction
  on property: localization regulation
  some values from: PMO:00025081
subclass of: Restriction
  on property: translocation regulation
  some values from: PMO:00025081
subclass of: Restriction
  on property: mutation regulation
  some values from: PMO:00025066
subclass of: Restriction
  on property: impact of
  some values from: PMO:00025066
PMOID: PMO:00015141
Subclass_of: owl:Thing
Tree Number: T6

Inorganic Chemicals
type: Class
subclass of: Chemical and Drug
MCID: MC00006870
PMOID: PMO:00015142
Subclass_of: Chemical and Drug
Synonym: Chemicals, Inorganic
Synonym: Inorganic Chemical
Synonym: Inorganic Chemicals [Chemical/Ingredient]
Synonym: Inorganic chemical
Synonym: Inorganic chemical (substance)
Synonym: Inorganic chemical compound
Synonym: Inorganic chemical compound, NOS
Synonym: Inorganic chemical, NOS
Synonym: Inorganic compound
Synonym: Inorganic compounds
Tree Number: T6.1
database_cross_reference: AOD:0000019569
database_cross_reference: CHV:0000006749
database_cross_reference: LCH_NW:sh86005967
database_cross_reference: MSH:D007287
database_cross_reference: NCI:C579
database_cross_reference: NDFRT:N0000008257
database_cross_reference: RCD:Xa4Hs
database_cross_reference: SNM:E-5010
database_cross_reference: SNM:U000129
database_cross_reference: SNMI:C-10090
database_cross_reference: SNOMEDCT_US:58295004

Acids
type: Class
subclass of: Inorganic Chemicals
MCID: MC00000244
PMOID: PMO:00015143
Subclass_of: Inorganic Chemicals
Synonym: ACID
Synonym: Acid
Synonym: Acid (substance)
Synonym: Acid, NOS
Synonym: Acidic
Synonym: Acids [Chemical/Ingredient]
Synonym: acid
Synonym: acid substances
Synonym: acidity
Synonym: acids
Tree Number: T6.1.1
database_cross_reference: AOD:0000000749
database_cross_reference: CCPSS:0034137
database_cross_reference: CHV:0000000638
database_cross_reference: CSP:0030-0942
database_cross_reference: LCH:U000037
database_cross_reference: LCH_NW:sh85000532
database_cross_reference: LNC:LP20964-0
database_cross_reference: LNC:LP28790-1
database_cross_reference: MEDCIN:250653
database_cross_reference: MSH:D000143
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C48057
database_cross_reference: NCI_NCI-GLOSS:CDR0000642987
database_cross_reference: NCI_NCI-GLOSS:CDR0000642991
database_cross_reference: NDFRT:N0000007626
database_cross_reference: PSY:00550
database_cross_reference: RCD:X794A
database_cross_reference: SNM:E-5002
database_cross_reference: SNMI:C-10040
database_cross_reference: SNOMEDCT_US:34957004

Acids, Noncarboxylic
type: Class
subclass of: Acids
MCID: MC00000249
PMOID: PMO:00015144
Subclass_of: Acids
Synonym: Acids, Noncarboxylic [Chemical/Ingredient]
Synonym: Noncarboxylic Acids
Tree Number: T6.1.1.1
database_cross_reference: MSH:D000148
database_cross_reference: NDFRT:N0000007630

Boric Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Boron Compounds
MCID: MC00001886
PMOID: PMO:00015145
Subclass_of: Acids, Noncarboxylic
Subclass_of: Boron Compounds
Synonym: Acids, Boric
Synonym: Boric Acids [Chemical/Ingredient]
Tree Number: T6.1.1.1.1
Tree Number: T6.1.4.2
Tree Number: T6.2.11.2
database_cross_reference: MSH:D001888
database_cross_reference: NDFRT:N0000008066

Borinic Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Boron Compounds
MCID: MC00001887
PMOID: PMO:00015146
Subclass_of: Acids, Noncarboxylic
Subclass_of: Boron Compounds
Synonym: Acids, Borinic
Synonym: Borinic Acids [Chemical/Ingredient]
Tree Number: T6.1.1.1.2
Tree Number: T6.1.4.3
Tree Number: T6.2.11.3
database_cross_reference: MSH:D001889
database_cross_reference: NDFRT:N0000166857

Boronic Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Boron Compounds
MCID: MC00001892
PMOID: PMO:00015147
Subclass_of: Acids, Noncarboxylic
Subclass_of: Boron Compounds
Synonym: Acids, Boronic
Synonym: Boronic Acids [Chemical/Ingredient]
Tree Number: T6.1.1.1.3
Tree Number: T6.1.4.4
Tree Number: T6.2.11.4
database_cross_reference: MSH:D001897
database_cross_reference: NDFRT:N0000011463

Bortezomib
type: Class
subclass of: Boronic Acids
subclass of: Pyrazines
MCID: MC00401165
PMOID: PMO:00015148
Subclass_of: Boronic Acids
Subclass_of: Pyrazines
Synonym: Act Bortezomib
Synonym: BORTEZOMIB
Synonym: Bortezomib (product)
Synonym: Bortezomib (substance)
Synonym: Bortezomib [Chemical/Ingredient]
Synonym: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
Synonym: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
Synonym: PMS-bortezomib
Synonym: [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid
Synonym: [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
Tree Number: T6.1.4.4.1
Tree Number: T6.2.11.4.1
Tree Number: T6.3.5.18.2
database_cross_reference: ATC:L01XX32
database_cross_reference: CHV:0000055829
database_cross_reference: DRUGBANK:DB00188
database_cross_reference: MEDCIN:258083
database_cross_reference: MMSL:17263
database_cross_reference: MMSL:d04871
database_cross_reference: MSH:D000069286
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:69G8BD63PP
database_cross_reference: NCI:C1851
database_cross_reference: NCI_DCP:31947
database_cross_reference: NCI_FDA:69G8BD63PP
database_cross_reference: NCI_NCI-GLOSS:CDR0000269133
database_cross_reference: NDDF:009985
database_cross_reference: NDFRT:N0000010079
database_cross_reference: NDFRT:N0000148811
database_cross_reference: PDQ:CDR0000043560
database_cross_reference: RXNORM:358258
database_cross_reference: SNOMEDCT_US:398907002
database_cross_reference: SNOMEDCT_US:407097007
database_cross_reference: VANDF:4021393

Carbonic Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Carbon Compounds, Inorganic
MCID: MC00002244
PMOID: PMO:00015149
Subclass_of: Acids, Noncarboxylic
Subclass_of: Carbon Compounds, Inorganic
Synonym: Acid, Carbonic
Synonym: Carbonic Acid [Chemical/Ingredient]
Synonym: Carbonic acid
Synonym: Carbonic acid (substance)
Synonym: carbonic acid
Tree Number: T6.1.1.1.4
Tree Number: T6.1.16.4
database_cross_reference: CHV:0000002400
database_cross_reference: LCH_NW:sh89006832
database_cross_reference: MSH:D002255
database_cross_reference: NDFRT:N0000008133
database_cross_reference: SNM:F-10190
database_cross_reference: SNMI:C-10523
database_cross_reference: SNOMEDCT_US:37938000

Hydrochloric Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Chlorine Compounds
MCID: MC00006458
PMOID: PMO:00015150
Subclass_of: Acids, Noncarboxylic
Subclass_of: Chlorine Compounds
Synonym: Acid, Hydrochloric
Synonym: Acid, Muriatic
Synonym: Chloride, Hydrogen
Synonym: HCL
Synonym: HCl
Synonym: HYDROCHLORIC ACID
Synonym: Hydrochloric Acid (HCL)
Synonym: Hydrochloric Acid [Chemical/Ingredient]
Synonym: Hydrochloric acid
Synonym: Hydrochloric acid (product)
Tree Number: T6.1.1.1.5
Tree Number: T6.1.20.4
database_cross_reference: ALT:HAMCP
database_cross_reference: AOD:0000019572
database_cross_reference: ATC:A09AB03
database_cross_reference: ATC:B05XA13
database_cross_reference: CHV:0000006346
database_cross_reference: CSP:1371-6102
database_cross_reference: LCH:U002273
database_cross_reference: LCH_NW:sh85063381
database_cross_reference: MEDCIN:41265
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D006851
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: MTHSPL:QTT17582CB
database_cross_reference: NCI:C76716
database_cross_reference: NCI_FDA:QTT17582CB
database_cross_reference: NDDF:001112
database_cross_reference: NDFRT:N0000006448
database_cross_reference: NDFRT:N0000146547
database_cross_reference: RCD:X90Ed
database_cross_reference: RXNORM:5486
database_cross_reference: SNM:E-5022
database_cross_reference: SNMI:C-10220
database_cross_reference: SNOMEDCT_US:27763000
database_cross_reference: SNOMEDCT_US:420502008
database_cross_reference: VANDF:4018214

Hydrogen Cyanide
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Nitrogen Compounds
MCID: MC00006465
PMOID: PMO:00015151
Subclass_of: Acids, Noncarboxylic
Subclass_of: Nitrogen Compounds
Synonym: Acid, Hydrocyanic
Synonym: Cyanhydric acid
Synonym: Cyanide, Hydrogen
Synonym: HYDROGEN CYANIDE
Synonym: Hydrocyanic Acid
Synonym: Hydrocyanic acid
Synonym: Hydrocyanic acid (substance)
Synonym: Hydrogen Cyanide [Chemical/Ingredient]
Synonym: Hydrogen cyanide
Synonym: Prussic acid
Tree Number: T6.1.1.1.6
Tree Number: T6.1.33.5
database_cross_reference: CHV:0000006352
database_cross_reference: LCH:U002275
database_cross_reference: LCH_NW:sh85063385
database_cross_reference: MSH:D006856
database_cross_reference: MTH:U001989
database_cross_reference: MTHSPL:2WTB3V159F
database_cross_reference: NCI:C77470
database_cross_reference: NCI_FDA:2WTB3V159F
database_cross_reference: NDFRT:N0000008281
database_cross_reference: RCD:XaD1S
database_cross_reference: RXNORM:1367183
database_cross_reference: SNM:E-5054
database_cross_reference: SNMI:C-10540
database_cross_reference: SNOMEDCT_US:54841005

Hydrofluoric Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Fluorine Compounds
MCID: MC00006467
PMOID: PMO:00015152
Subclass_of: Acids, Noncarboxylic
Subclass_of: Fluorine Compounds
Synonym: Acid, Fluohydric
Synonym: Acid, Fluorhydric
Synonym: Acid, Hydrofluoric
Synonym: Alpha-Pro
Synonym: Denti-Care Topical Fluoride Foam Bubble Gum
Synonym: Denti-Care Topical Fluoride Foam Grape
Synonym: Denti-Care Topical Fluoride Foam Orange
Synonym: Denti-Care Topical Fluoride Foam Raspberry
Synonym: Denti-Care Topical Sodium Fluoride Strawberry
Synonym: Fluohydric Acid
Tree Number: T6.1.1.1.7
Tree Number: T6.1.25.1
database_cross_reference: CHV:0000006353
database_cross_reference: CSP:0030-0942
database_cross_reference: DRUGBANK:DB11072
database_cross_reference: LCH:U002276
database_cross_reference: LCH_NW:sh85063411
database_cross_reference: LNC:LP34850-5
database_cross_reference: LNC:MTHU017657
database_cross_reference: MMSL:4846
database_cross_reference: MSH:D006858
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:RGL5YE86CZ
database_cross_reference: NCI:C82286
database_cross_reference: NCI_FDA:RGL5YE86CZ
database_cross_reference: NDDF:003889
database_cross_reference: NDFRT:N0000006470
database_cross_reference: NDFRT:N0000146794
database_cross_reference: RCD:XaD6A
database_cross_reference: RCD:XaD6B
database_cross_reference: RXNORM:5496
database_cross_reference: SNM:E-5023
database_cross_reference: SNMI:C-10230
database_cross_reference: SNOMEDCT_US:311993005
database_cross_reference: SNOMEDCT_US:42757007
database_cross_reference: VANDF:4018471

Hydrogen Sulfide
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Gases
subclass of: Sulfur Compounds
MCID: MC00006470
PMOID: PMO:00015153
Subclass_of: Acids, Noncarboxylic
Subclass_of: Gases
Subclass_of: Sulfur Compounds
Synonym: Hydrogen Sulfide [Chemical/Ingredient]
Synonym: Hydrogen sulfide
Synonym: Hydrogen sulfide (H2S)
Synonym: Hydrogen sulfide (substance)
Synonym: Hydrogen sulphide
Synonym: Sulfide, Hydrogen
Synonym: Sulfur hydride
Synonym: Sulphur hydride
Synonym: hydrogen sulfide
Synonym: hydrogen sulphide
Tree Number: T6.1.1.1.8
Tree Number: T6.1.13.1
Tree Number: T6.1.8.8
database_cross_reference: CHV:0000006357
database_cross_reference: CSP:2837-1786
database_cross_reference: LCH_NW:sh85063433
database_cross_reference: LNC:LP15644-5
database_cross_reference: LNC:MTHU011758
database_cross_reference: MSH:D006862
database_cross_reference: MTH:U001990
database_cross_reference: NDFRT:N0000008233
database_cross_reference: RCD:XaD1V
database_cross_reference: RCDAE:XaD1V
database_cross_reference: SNM:E-5082
database_cross_reference: SNMI:C-10812
database_cross_reference: SNOMEDCT_US:27390006

Hypochlorous Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Oxides
subclass of: Reactive Oxygen Species
subclass of: Chlorine Compounds
MCID: MC00006604
PMOID: PMO:00015154
Subclass_of: Acids, Noncarboxylic
Subclass_of: Chlorine Compounds
Subclass_of: Oxides
Subclass_of: Reactive Oxygen Species
Synonym: HYPOCHLOROUS ACID
Synonym: Hypochlorous Acid [Chemical/Ingredient]
Synonym: Hypochlorous acid
Synonym: Hypochlorous acid (substance)
Synonym: hypochlorous acid
Tree Number: T6.1.1.1.9
Tree Number: T6.1.18.1.4
Tree Number: T6.1.20.5
Tree Number: T6.1.7.2.1
database_cross_reference: CHV:0000006469
database_cross_reference: MSH:D006997
database_cross_reference: MTHSPL:712K4CDC10
database_cross_reference: NDDF:013504
database_cross_reference: NDFRT:N0000007498
database_cross_reference: NDFRT:N0000188990
database_cross_reference: RXNORM:1483316
database_cross_reference: SNMI:C-10410
database_cross_reference: SNOMEDCT_US:35690007
database_cross_reference: VANDF:4032746

Nitrous Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Nitrogen Compounds
MCID: MC00008963
PMOID: PMO:00015155
Subclass_of: Acids, Noncarboxylic
Subclass_of: Nitrogen Compounds
Synonym: Acid, Nitrous
Synonym: Nitrous Acid [Chemical/Ingredient]
Synonym: Nitrous acid
Synonym: Nitrous acid (substance)
Synonym: nitrous acid
Tree Number: T6.1.1.1.10
Tree Number: T6.1.33.7
database_cross_reference: AOD:0000019600
database_cross_reference: CSP:2083-3379
database_cross_reference: LCH:U003252
database_cross_reference: LCH_NW:sh85092096
database_cross_reference: MSH:D009608
database_cross_reference: NDFRT:N0000008205
database_cross_reference: SNM:E-5079
database_cross_reference: SNMI:C-10730
database_cross_reference: SNOMEDCT_US:30749004

Perchlorates
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Chlorine Compounds
MCID: MC00067194
PMOID: PMO:00015156
Subclass_of: Acids, Noncarboxylic
Subclass_of: Chlorine Compounds
Synonym: Perchlorates [Chemical/Ingredient]
Tree Number: T6.1.1.1.11
Tree Number: T6.1.20.6
database_cross_reference: MSH:D010472
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000189416

Periodic Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Iodine Compounds
MCID: MC00009918
PMOID: PMO:00015157
Subclass_of: Acids, Noncarboxylic
Subclass_of: Iodine Compounds
Synonym: Acid, Paraperiodic
Synonym: Acid, Periodic
Synonym: Paraperiodic Acid
Synonym: Periodic Acid [Chemical/Ingredient]
Synonym: Periodic acid
Synonym: Periodic acid (H5IO6)
Synonym: paraperiodic acid
Synonym: periodic acid
Tree Number: T6.1.1.1.12
Tree Number: T6.1.27.4
database_cross_reference: AOD:0000019596
database_cross_reference: CHV:0000009500
database_cross_reference: CSP:0030-0942
database_cross_reference: LCH_NW:sh89006199
database_cross_reference: MSH:D010504
database_cross_reference: NDFRT:N0000166200

Silicic Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Silicon Dioxide
MCID: MC00011860
PMOID: PMO:00015158
Subclass_of: Acids, Noncarboxylic
Subclass_of: Silicon Dioxide
Synonym: Gel, Hydrated Silica
Synonym: HYDRATED SILICA
Synonym: Hydrate, Silica
Synonym: Hydrate, Silicate
Synonym: Hydrated Silica
Synonym: Hydrated Silica Gel
Synonym: Hydrated silica
Synonym: Silica Gel, Hydrated
Synonym: Silica Hydrate
Synonym: Silicate Hydrate
Tree Number: T6.1.1.1.13
Tree Number: T6.1.29.2.3
database_cross_reference: LCH:U004314
database_cross_reference: LCH_NW:sh85122508
database_cross_reference: MSH:D012824
database_cross_reference: MTHSPL:Y6O7T4G8P9
database_cross_reference: NDDF:007387
database_cross_reference: NDDF:010496
database_cross_reference: NDFRT:N0000007598
database_cross_reference: RXNORM:1311243

Sulfur Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Sulfur Compounds
MCID: MC00012411
PMOID: PMO:00015159
Subclass_of: Acids, Noncarboxylic
Subclass_of: Sulfur Compounds
Synonym: Acids, Sulfur
Synonym: Sulfur Acids [Chemical/Ingredient]
Synonym: Sulfur acids
Synonym: acid sulfur
Synonym: sulfur acid
Synonym: sulfur acids
Tree Number: T6.1.1.1.14
Tree Number: T6.1.13.3
Tree Number: T6.2.32.11
database_cross_reference: CHV:0000011875
database_cross_reference: LCH_NW:sh2007003784
database_cross_reference: MSH:D013456
database_cross_reference: NDFRT:N0000008248

Sulfinic Acids
type: Class
subclass of: Sulfur Acids
MCID: MC00012391
PMOID: PMO:00015160
Subclass_of: Sulfur Acids
Synonym: Acids, Sulfinic
Synonym: Sulfinic Acids [Chemical/Ingredient]
Tree Number: T6.1.13.3.1
Tree Number: T6.2.32.11.2
database_cross_reference: MSH:D013441
database_cross_reference: NDFRT:N0000166476

Sulfonic Acids
type: Class
subclass of: Sulfur Acids
MCID: MC00012405
PMOID: PMO:00015161
Subclass_of: Sulfur Acids
Synonym: Acids, Sulfonic
Synonym: Sulfonic Acids [Chemical/Ingredient]
Synonym: acid sulfonic
Synonym: sulfonic acid
Tree Number: T6.1.13.3.2
Tree Number: T6.2.32.11.3
database_cross_reference: AOD:0000019953
database_cross_reference: CHV:0000011870
database_cross_reference: MSH:D013451
database_cross_reference: NDDF:007190
database_cross_reference: NDFRT:N0000008245

Sulfuric Acids
type: Class
subclass of: Sulfur Acids
MCID: MC00012420
PMOID: PMO:00015163
Subclass_of: Sulfur Acids
Synonym: Acids, Sulfuric
Synonym: Sulfuric Acids [Chemical/Ingredient]
Synonym: Sulfuric acid
Tree Number: T6.1.13.3.3
Tree Number: T6.2.32.11.4
database_cross_reference: LCH_NW:sh85130391
database_cross_reference: MSH:D013464
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008059

Nitric Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Nitrogen Compounds
MCID: MC00033272
PMOID: PMO:00015165
Subclass_of: Acids, Noncarboxylic
Subclass_of: Nitrogen Compounds
Synonym: Acid, Nitric
Synonym: Aqua fortis / nitric acid
Synonym: Hydrogen Nitrate
Synonym: NITRIC ACID
Synonym: Nitric Acid [Chemical/Ingredient]
Synonym: Nitric acid
Synonym: Nitric acid (substance)
Synonym: acid nitric
Synonym: aqua fortis/nitric acid
Synonym: nitric acid
Tree Number: T6.1.1.1.15
Tree Number: T6.1.33.9
database_cross_reference: ALT:HAAEZ
database_cross_reference: CHV:0000014505
database_cross_reference: LCH:U005843
database_cross_reference: LCH_NW:sh85092048
database_cross_reference: MSH:D017942
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:411VRN1TV4
database_cross_reference: NCI:C28202
database_cross_reference: NCI_FDA:411VRN1TV4
database_cross_reference: NCI_NCI-GLOSS:CDR0000044136
database_cross_reference: NDDF:005607
database_cross_reference: NDFRT:N0000008166
database_cross_reference: RCD:X90Ej
database_cross_reference: RXNORM:1311391
database_cross_reference: SNM:E-5024
database_cross_reference: SNMI:C-10240
database_cross_reference: SNOMEDCT_US:59442008

Phosphorus Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Phosphorus Compounds
MCID: MC00067408
PMOID: PMO:00015166
Subclass_of: Acids, Noncarboxylic
Subclass_of: Phosphorus Compounds
Synonym: Acids, Phosphorus
Synonym: Phosphorus Acids [Chemical/Ingredient]
Synonym: phosphorus acid
Tree Number: T6.1.1.1.16
Tree Number: T6.1.15.4
database_cross_reference: CSP:0030-0942
database_cross_reference: MSH:D017976
database_cross_reference: NDFRT:N0000007696

Phosphinic Acids
type: Class
subclass of: Phosphorus Acids
subclass of: Organophosphorus Compounds
MCID: MC00010110
PMOID: PMO:00015167
Subclass_of: Organophosphorus Compounds
Subclass_of: Phosphorus Acids
Synonym: Acids, Hypophosphorous
Synonym: Acids, Phosphinic
Synonym: Hypophosphorous Acids
Synonym: Phosphinic Acids [Chemical/Ingredient]
Synonym: Phosphinic acid
Tree Number: T6.1.15.4.1
Tree Number: T6.2.29.3
database_cross_reference: LCH_NW:sh2005008190
database_cross_reference: MSH:D010721
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166429

Phosphoric Acids
type: Class
subclass of: Phosphorus Acids
MCID: MC00010149
PMOID: PMO:00015168
Subclass_of: Phosphorus Acids
Synonym: Acids, Phosphoric
Synonym: Phosphoric Acids [Chemical/Ingredient]
Synonym: acid phosphoric
Synonym: phosphoric acid
Tree Number: T6.1.15.4.2
database_cross_reference: AOD:0000019623
database_cross_reference: CHV:0000009675
database_cross_reference: MSH:D010756
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000006915

Struvite
type: Class
subclass of: Magnesium Compounds
MCID: MC00038346
PMOID: PMO:00015170
Subclass_of: Magnesium Compounds
Synonym: Struvate
Synonym: Struvate (substance)
Synonym: Struvite (substance)
Synonym: Struvite [Chemical/Ingredient]
Synonym: struvite
Tree Number: T6.1.28.1
database_cross_reference: CHV:0000014871
database_cross_reference: MSH:D000069877
database_cross_reference: NDFRT:N0000192949
database_cross_reference: RCD:XC0ux
database_cross_reference: SNOMEDCT_US:264928008

Acidulated Phosphate Fluoride
type: Class
subclass of: Sodium Fluoride
subclass of: PMO:00024406
MCID: MC00000250
PMOID: PMO:00015171
Subclass_of: Cariostatic Agents
Subclass_of: Sodium Fluoride
Synonym: ACIDULATED PHOSPHATE FLUORIDE
Synonym: Acid Phosphate Fluoride
Synonym: Acidulated Phosphate Fluoride [Chemical/Ingredient]
Synonym: Acidulated phosphate fluoride
Synonym: Acidulated phosphate fluoride (substance)
Synonym: Fluoride, Acid Phosphate
Synonym: Fluoride, Acidulated Phosphate
Synonym: Phosphate Fluoride, Acidulated
Synonym: Phosphoric acid, mixt. with sodium fluoride (NaF)
Synonym: acidulated fluoride phosphate
Tree Number: T6.1.31.3.1
Tree Number: T6.14.4.1
database_cross_reference: MEDCIN:250631
database_cross_reference: MMSL:10398
database_cross_reference: MSH:D000149
database_cross_reference: NDFRT:N0000006411
database_cross_reference: NDFRT:N0000148064
database_cross_reference: RXNORM:236
database_cross_reference: SNMI:C-B70C2
database_cross_reference: SNOMEDCT_US:55495002
database_cross_reference: VANDF:4019988

Calcium Phosphates
type: Class
subclass of: Calcium Compounds
MCID: MC00002131
PMOID: PMO:00015172
Subclass_of: Calcium Compounds
Synonym: Calcium Phosphates [Chemical/Ingredient]
Synonym: Calcium phosphates
Synonym: Calcium/Phosphate
Synonym: Phosphates, Calcium
Synonym: calcium phosphates
Synonym: phosphates calcium
Tree Number: T6.1.24.5
database_cross_reference: CHV:0000002306
database_cross_reference: DRUGBANK:DB11348
database_cross_reference: LNC:LP28906-3
database_cross_reference: LNC:MTHU006836
database_cross_reference: MSH:D002130
database_cross_reference: NDFRT:N0000007989

Apatites
type: Class
subclass of: Calcium Phosphates
subclass of: Minerals
MCID: MC00001148
PMOID: PMO:00015173
Subclass_of: Calcium Phosphates
Subclass_of: Minerals
Synonym: Apatite
Synonym: Apatites [Chemical/Ingredient]
Synonym: apatite
Tree Number: T6.1.11.1
Tree Number: T6.1.24.5.1
database_cross_reference: CHV:0000001365
database_cross_reference: CSP:0532-2130
database_cross_reference: DRUGBANK:DB09484
database_cross_reference: LCH:U000323
database_cross_reference: LCH_NW:sh85005932
database_cross_reference: MSH:D001031
database_cross_reference: NDFRT:N0000166283
database_cross_reference: RCD:X80N1
database_cross_reference: SNOMEDCT_US:259546007

Hydroxyapatites
type: Class
subclass of: Apatites
MCID: MC00006485
PMOID: PMO:00015174
Subclass_of: Apatites
Synonym: Derivatives, Hydroxyapatite
Synonym: Hydroxyapatite Derivatives
Synonym: Hydroxyapatites [Chemical/Ingredient]
Tree Number: T6.1.11.1.1
database_cross_reference: MSH:D006882
database_cross_reference: NDFRT:N0000166284

Calcium Pyrophosphate
type: Class
subclass of: Calcium Phosphates
MCID: MC00002133
PMOID: PMO:00015176
Subclass_of: Calcium Phosphates
Synonym: CALCIUM PYROPHOSPHATE
Synonym: Calcium Diphosphate
Synonym: Calcium Pyrophosphate [Chemical/Ingredient]
Synonym: Calcium pyrophosphate
Synonym: Calcium pyrophosphate (substance)
Synonym: Diphosphate, Calcium
Synonym: Diphosphoric acid, calcium salt
Synonym: Pyrophosphate, Calcium
Synonym: calcium diphosphate
Synonym: calcium pyrophosphate
Tree Number: T6.1.24.5.2
database_cross_reference: CHV:0000002307
database_cross_reference: MSH:D002131
database_cross_reference: MTHSPL:X69NU20D19
database_cross_reference: NCI:C75639
database_cross_reference: NCI_FDA:X69NU20D19
database_cross_reference: NDDF:010438
database_cross_reference: NDFRT:N0000166212
database_cross_reference: RCD:XaDpH
database_cross_reference: RXNORM:1362901
database_cross_reference: SNOMEDCT_US:312258005

Technetium Tc 99m Pyrophosphate
type: Class
subclass of: Technetium Compounds
MCID: MC00043234
PMOID: PMO:00015179
Subclass_of: Technetium Compounds
Synonym: 99mTc Pyrophosphate
Synonym: 99mTc-Pyrophosphate
Synonym: Diphosphoric Acid, Technetium Salt
Synonym: Kit for the Preparation of Technetium Tc99m Pyrophosphate
Synonym: TC PYRO
Synonym: TC PYROPHOSPHATE 099M
Synonym: TECHNETIUM TC PYROPHOSPHATE 099M
Synonym: TECHNETIUM TC-99M PYROPHOSPHATE
Synonym: Tc 99m Pyrophosphate
Synonym: Tc 99m-Pyrophosphate
Tree Number: T6.1.17.3
database_cross_reference: DRUGBANK:DB09165
database_cross_reference: MSH:D016698
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5L76I61H2B
database_cross_reference: NCI:C90869
database_cross_reference: NCI_FDA:5L76I61H2B
database_cross_reference: NDFRT:N0000166195
database_cross_reference: RXNORM:1488368
database_cross_reference: SNM:E-5278

Tin Polyphosphates
type: Class
subclass of: Tin Compounds
MCID: MC00012869
PMOID: PMO:00015180
Subclass_of: Tin Compounds
Synonym: Polyphosphates, Tin
Synonym: Tin Polyphosphates [Chemical/Ingredient]
Tree Number: T6.1.40.2
database_cross_reference: MSH:D014003
database_cross_reference: NDFRT:N0000166217

Phosphoramides
type: Class
subclass of: Organophosphorus Compounds
MCID: MC00909592
PMOID: PMO:00015181
Subclass_of: Organophosphorus Compounds
Synonym: Phosphoramides [Chemical/Ingredient]
Tree Number: T6.2.29.7
database_cross_reference: MSH:D063088
database_cross_reference: NDFRT:N0000185716

Phosphotungstic Acid
type: Class
subclass of: Tungsten Compounds
MCID: MC00010166
PMOID: PMO:00015182
Subclass_of: Tungsten Compounds
Synonym: Acid, Phosphotungstic
Synonym: Phosphotungstic Acid [Chemical/Ingredient]
Synonym: Tungsten hydroxide oxide phosphate
Tree Number: T6.1.41.1
database_cross_reference: MSH:D010772
database_cross_reference: NDFRT:N0000166201

Phosphorous Acids
type: Class
subclass of: Phosphorus Acids
MCID: MC00010150
PMOID: PMO:00015183
Subclass_of: Phosphorus Acids
Synonym: Acids, Phosphorous
Synonym: Phosphorous Acids [Chemical/Ingredient]
Tree Number: T6.1.15.4.3
database_cross_reference: MSH:D010757
database_cross_reference: NDFRT:N0000166426

Hydrobromic Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Bromine Compounds
MCID: MC00028860
PMOID: PMO:00015184
Subclass_of: Acids, Noncarboxylic
Subclass_of: Bromine Compounds
Synonym: Acid, Hydrobromic
Synonym: Bromide, Hydrogen
Synonym: HYDROBROMIC ACID
Synonym: Hydrobromic Acid [Chemical/Ingredient]
Synonym: Hydrobromic acid
Synonym: Hydrobromic acid (substance)
Synonym: Hydrogen Bromide
Synonym: Hydrogen bromide
Synonym: hydrobromic acid
Tree Number: T6.1.1.1.17
Tree Number: T6.1.19.2
database_cross_reference: LCH:U005118
database_cross_reference: LCH_NW:sh85063370
database_cross_reference: MSH:D018054
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:3IY7CNP8XJ
database_cross_reference: NDDF:010263
database_cross_reference: NDFRT:N0000166202
database_cross_reference: RXNORM:1426869
database_cross_reference: SNM:E-5021
database_cross_reference: SNMI:C-10210
database_cross_reference: SNOMEDCT_US:84274008

Lewis Acids
type: Class
subclass of: Acids
subclass of: Organic Chemicals
MCID: MC00106469
PMOID: PMO:00015185
Subclass_of: Acids
Subclass_of: Organic Chemicals
Synonym: Acids, Lewis
Synonym: Lewis Acids [Chemical/Ingredient]
Synonym: Lewis acid
Synonym: Lewis acid (substance)
Synonym: Lewis acids
Tree Number: T6.1.1.2
Tree Number: T6.2.42
database_cross_reference: LCH_NW:sh89004433
database_cross_reference: MSH:D058116
database_cross_reference: NDFRT:N0000182057
database_cross_reference: SNMI:C-10043
database_cross_reference: SNOMEDCT_US:49426007

Alkalies
type: Class
subclass of: Inorganic Chemicals
MCID: MC00000555
PMOID: PMO:00015186
Subclass_of: Inorganic Chemicals
Synonym: Alkali
Synonym: Alkali (substance)
Synonym: Alkali, NOS
Synonym: Alkalies [Chemical/Ingredient]
Synonym: Alkalis
Synonym: alkali
Synonym: alkalies
Synonym: alkalis
Synonym: alkalising
Synonym: base
Tree Number: T6.1.2
database_cross_reference: AOD:0000028722
database_cross_reference: CHV:0000000897
database_cross_reference: LCH:U000144
database_cross_reference: LCH_NW:sh85003591
database_cross_reference: MSH:D000468
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI_NCI-GLOSS:CDR0000643003
database_cross_reference: NCI_NCI-GLOSS:CDR0000689975
database_cross_reference: NDFRT:N0000008132
database_cross_reference: RCD:X794B
database_cross_reference: SNM:E-5003
database_cross_reference: SNMI:C-10055
database_cross_reference: SNOMEDCT_US:63813000

Carbonates
type: Class
subclass of: Carbonic Acid
subclass of: Alkalies
MCID: MC00002243
PMOID: PMO:00015187
Subclass_of: Alkalies
Subclass_of: Carbonic Acid
Synonym: Carbonate
Synonym: Carbonate (substance)
Synonym: Carbonates [Chemical/Ingredient]
Synonym: carbonate
Synonym: carbonated
Synonym: carbonates
Tree Number: T6.1.16.4.1
Tree Number: T6.1.2.1
database_cross_reference: CHV:0000002399
database_cross_reference: CSP:0558-7159
database_cross_reference: LCH:U000789
database_cross_reference: LCH_NW:sh85020136
database_cross_reference: LNC:LP15472-1
database_cross_reference: LNC:MTHU004921
database_cross_reference: MSH:D002254
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007504
database_cross_reference: RCD:X8071
database_cross_reference: SNOMEDCT_US:259094000

Lithium Carbonate
type: Class
subclass of: Carbonates
subclass of: Lithium Compounds
MCID: MC00043212
PMOID: PMO:00015188
Subclass_of: Carbonates
Subclass_of: Lithium Compounds
Synonym: Carbonate, Dilithium
Synonym: Carbonate, Lithium
Synonym: Carbonic acid, dilithium salt
Synonym: Dilithium Carbonate
Synonym: LITHIUM CARBONATE
Synonym: Lithium Carbonate [Chemical/Ingredient]
Synonym: Lithium carbonate
Synonym: Lithium carbonate (product)
Synonym: Lithium carbonate (substance)
Synonym: Lithium carbonate preparation
Tree Number: T6.1.2.1.1
Tree Number: T6.1.44.1
database_cross_reference: CHV:0000015502
database_cross_reference: DRUGBANK:DB01356
database_cross_reference: MEDCIN:41360
database_cross_reference: MMSL:1990
database_cross_reference: MMSL:4986
database_cross_reference: MSH:D016651
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2BMD2GNA4V
database_cross_reference: NCI:C1318
database_cross_reference: NCI_DTP:NSC0016895
database_cross_reference: NCI_FDA:2BMD2GNA4V
database_cross_reference: NDDF:001533
database_cross_reference: NDFRT:N0000006445
database_cross_reference: NDFRT:N0000146351
database_cross_reference: PDQ:CDR0000039491
database_cross_reference: PSY:28610
database_cross_reference: RCD:d61..
database_cross_reference: RXNORM:42351
database_cross_reference: SNM:E-7960
database_cross_reference: SNMI:C-63C11
database_cross_reference: SNOMEDCT_US:16977003
database_cross_reference: SNOMEDCT_US:387095003
database_cross_reference: USPMG:MTHU000812
database_cross_reference: VANDF:4018007

Hydroxides
type: Class
subclass of: Alkalies
MCID: MC00006481
PMOID: PMO:00015189
Subclass_of: Alkalies
Synonym: Hydroxides [Chemical/Ingredient]
Synonym: hydroxides
Tree Number: T6.1.2.2
database_cross_reference: AOD:0000019573
database_cross_reference: CHV:0000006371
database_cross_reference: LCH:U002290
database_cross_reference: LCH_NW:sh85063504
database_cross_reference: MSH:D006878
database_cross_reference: MTH:U001992
database_cross_reference: NDFRT:N0000007982

Aluminum Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Aluminum Compounds
MCID: MC00000683
PMOID: PMO:00015190
Subclass_of: Aluminum Compounds
Subclass_of: Hydroxides
Synonym: ALUMINUM (AS HYDROXIDE)
Synonym: ALUMINUM HYDROXIDE
Synonym: Al(OH)3
Synonym: Alum Adjuvant
Synonym: Alumina, Hydrated
Synonym: Aluminium hydroxide
Synonym: Aluminium hydroxide (in vac)
Synonym: Aluminium hydroxide (in vaccine)
Synonym: Aluminium hydroxide - chemical
Synonym: Aluminium hydroxide [antacid]
Tree Number: T6.1.2.2.1
Tree Number: T6.1.21.2
database_cross_reference: ATC:A02AB01
database_cross_reference: CHV:0000000957
database_cross_reference: DRUGBANK:DB06723
database_cross_reference: LCH:U000170
database_cross_reference: LCH_NW:sh85004013
database_cross_reference: MEDCIN:40852
database_cross_reference: MMSL:4159
database_cross_reference: MMSL:7537
database_cross_reference: MMSL:d00978
database_cross_reference: MSH:D000536
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5QB0T2IUN0
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C39707
database_cross_reference: NCI_DTP:NSC0664400
database_cross_reference: NCI_FDA:5QB0T2IUN0
database_cross_reference: NDDF:001123
database_cross_reference: NDFRT:N0000006641
database_cross_reference: NDFRT:N0000146330
database_cross_reference: NDFRT:N0000146920
database_cross_reference: PDQ:CDR0000042000
database_cross_reference: RCD:X794W
database_cross_reference: RCD:XM0l1
database_cross_reference: RCD:a11..
database_cross_reference: RCD:ij1..
database_cross_reference: RCD:x02L7
database_cross_reference: RCDAE:X794W
database_cross_reference: RCDAE:XM0l1
database_cross_reference: RCDAE:a11..
database_cross_reference: RCDAE:ij1..
database_cross_reference: RCDAE:x02L7
database_cross_reference: RXNORM:612
database_cross_reference: SNM:E-8213
database_cross_reference: SNMI:C-84212
database_cross_reference: SNOMEDCT_US:255628000
database_cross_reference: SNOMEDCT_US:273944007
database_cross_reference: SNOMEDCT_US:316932002
database_cross_reference: SNOMEDCT_US:329185005
database_cross_reference: SNOMEDCT_US:80399002
database_cross_reference: VANDF:4017984
database_cross_reference: VANDF:4018607

Calcium Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Calcium Compounds
MCID: MC00002121
PMOID: PMO:00015191
Subclass_of: Calcium Compounds
Subclass_of: Hydroxides
Synonym: CALCIUM HYDROXIDE
Synonym: Ca(OH) - Calcium hydroxide
Synonym: Ca(OH) - calcium hydroxide
Synonym: Calcium Hydroxide [Chemical/Ingredient]
Synonym: Calcium hydroxide
Synonym: Calcium hydroxide (Ca(OH)2)
Synonym: Calcium hydroxide (substance)
Synonym: Hydroxide, Calcium
Synonym: LIME WATER
Synonym: Lime water
Tree Number: T6.1.2.2.2
Tree Number: T6.1.24.4
database_cross_reference: CHV:0000002301
database_cross_reference: LCH_NW:sh90004203
database_cross_reference: MEDCIN:199190
database_cross_reference: MMSL:72391
database_cross_reference: MMSL:7477
database_cross_reference: MSH:D002126
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:PF5DZW74VN
database_cross_reference: NCI:C77032
database_cross_reference: NCI_FDA:PF5DZW74VN
database_cross_reference: NDDF:001118
database_cross_reference: NDFRT:N0000006550
database_cross_reference: NDFRT:N0000147560
database_cross_reference: NDFRT:N0000147684
database_cross_reference: RCD:Xa6Yw
database_cross_reference: RXNORM:1910
database_cross_reference: SNM:E-8012
database_cross_reference: SNM:E-8052
database_cross_reference: SNMI:C-A7060
database_cross_reference: SNOMEDCT_US:7325009
database_cross_reference: VANDF:4019429
database_cross_reference: VANDF:4019587

Lye
type: Class
subclass of: Hydroxides
MCID: MC00007727
PMOID: PMO:00015192
Subclass_of: Hydroxides
Synonym: Lixivium
Synonym: Lye (substance)
Synonym: Lye [Chemical/Ingredient]
Synonym: lye
Synonym: lyes
Tree Number: T6.1.2.2.3
database_cross_reference: CHV:0000007587
database_cross_reference: LCH:U002753
database_cross_reference: LCH_NW:sh85079104
database_cross_reference: MSH:D008191
database_cross_reference: NDFRT:N0000166220
database_cross_reference: RCD:XaD1C
database_cross_reference: SNM:E-5030
database_cross_reference: SNMI:C-10300
database_cross_reference: SNOMEDCT_US:311721007
database_cross_reference: SNOMEDCT_US:61504000

Magnesium Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Magnesium Compounds
MCID: MC00007824
PMOID: PMO:00015193
Subclass_of: Hydroxides
Subclass_of: Magnesium Compounds
Synonym: Hydrate, Magnesium
Synonym: Hydroxide, Magnesium
Synonym: MAGNESIUM HYDROXIDE
Synonym: Magnesium Hydrate
Synonym: Magnesium Hydroxide [Chemical/Ingredient]
Synonym: Magnesium dihydroxide
Synonym: Magnesium hydrate
Synonym: Magnesium hydrate (substance)
Synonym: Magnesium hydroxide
Synonym: Magnesium hydroxide (Mg(OH)2)
Tree Number: T6.1.2.2.4
Tree Number: T6.1.28.2
database_cross_reference: ATC:A02AA04
database_cross_reference: ATC:G04BX01
database_cross_reference: CHV:0000007663
database_cross_reference: DRUGBANK:DB09104
database_cross_reference: MEDCIN:40864
database_cross_reference: MMSL:5013
database_cross_reference: MMSL:5579
database_cross_reference: MMSL:d00982
database_cross_reference: MSH:D008276
database_cross_reference: MTHSPL:NBZ3QY004S
database_cross_reference: NCI:C29262
database_cross_reference: NCI_DCP:1278
database_cross_reference: NCI_FDA:NBZ3QY004S
database_cross_reference: NDDF:001119
database_cross_reference: NDDF:001186
database_cross_reference: NDFRT:N0000006344
database_cross_reference: NDFRT:N0000146067
database_cross_reference: RCD:ae2..
database_cross_reference: RCD:x007O
database_cross_reference: RXNORM:6581
database_cross_reference: SNM:E-8215
database_cross_reference: SNM:E-8222
database_cross_reference: SNMI:C-84232
database_cross_reference: SNMI:C-84270
database_cross_reference: SNOMEDCT_US:25550008
database_cross_reference: SNOMEDCT_US:317584009
database_cross_reference: SNOMEDCT_US:387337001
database_cross_reference: SNOMEDCT_US:60468008
database_cross_reference: VANDF:4017693

Sodium Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Sodium Compounds
MCID: MC00011990
PMOID: PMO:00015194
Subclass_of: Hydroxides
Subclass_of: Sodium Compounds
Synonym: Caustic Soda
Synonym: Caustic alkali of sodium
Synonym: Hydroxide, Sodium
Synonym: SODIUM HYDROXIDE
Synonym: SOdium Hydroxide
Synonym: Soda, Caustic
Synonym: Sodium Hydroxide [Chemical/Ingredient]
Synonym: Sodium hydroxide
Synonym: Sodium hydroxide (Na(OH))
Synonym: Sodium hydroxide (substance)
Tree Number: T6.1.2.2.5
Tree Number: T6.1.31.5
database_cross_reference: AOD:0000019576
database_cross_reference: CHV:0000011492
database_cross_reference: DRUGBANK:DB11151
database_cross_reference: LCH:U004376
database_cross_reference: LCH_NW:sh85124265
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D012972
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:55X04QC32I
database_cross_reference: NCI:C74373
database_cross_reference: NCI_FDA:55X04QC32I
database_cross_reference: NDDF:001962
database_cross_reference: NDFRT:N0000007231
database_cross_reference: NDFRT:N0000146255
database_cross_reference: RCD:Xa0UK
database_cross_reference: RXNORM:9880
database_cross_reference: SNM:E-5031
database_cross_reference: SNMI:C-10310
database_cross_reference: SNOMEDCT_US:23423003
database_cross_reference: VANDF:4017904

Water
type: Class
subclass of: Hydroxides
subclass of: Oxides
MCID: MC00013692
PMOID: PMO:00015195
Subclass_of: Hydroxides
Subclass_of: Oxides
Synonym: Dihydrogen oxide
Synonym: H2O - Water
Synonym: Hydrogen Oxide
Synonym: WATER
Synonym: Water (substance)
Synonym: Water [Chemical/Ingredient]
Synonym: Water product
Synonym: Water product (product)
Synonym: Water product (substance)
Synonym: Watering
Tree Number: T6.1.18.1.12
Tree Number: T6.1.2.2.6
database_cross_reference: AOD:0000001140
database_cross_reference: CHV:0000013112
database_cross_reference: CSP:3156-9415
database_cross_reference: DRUGBANK:DB09145
database_cross_reference: LCH:U005007
database_cross_reference: LCH_NW:sh85145447
database_cross_reference: LNC:LA14387-7
database_cross_reference: LNC:LA16273-7
database_cross_reference: LNC:LP35030-3
database_cross_reference: LNC:LP7719-0
database_cross_reference: LNC:LP99666-7
database_cross_reference: LNC:MTHU001475
database_cross_reference: LNC:MTHU036072
database_cross_reference: MEDLINEPLUS:1435
database_cross_reference: MSH:D014867
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:059QF0KO0R
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C65147
database_cross_reference: NCI_CRCH:C65147
database_cross_reference: NCI_FDA:059QF0KO0R
database_cross_reference: NDDF:000738
database_cross_reference: NDFRT:N0000006428
database_cross_reference: NDFRT:N0000147042
database_cross_reference: RCD:XM0ll
database_cross_reference: RCD:x00C7
database_cross_reference: RXNORM:11295
database_cross_reference: SNM:E-5015
database_cross_reference: SNMI:C-10120
database_cross_reference: SNOMEDCT_US:11713004
database_cross_reference: SNOMEDCT_US:346712003
database_cross_reference: VANDF:4018738

Hydroxyl Radical
type: Class
subclass of: Hydroxides
subclass of: Reactive Oxygen Species
MCID: MC00028918
PMOID: PMO:00015202
Subclass_of: Hydroxides
Subclass_of: Reactive Oxygen Species
Synonym: Hydroxyl
Synonym: Hydroxyl Radical [Chemical/Ingredient]
Synonym: OH
Synonym: hydroxyl
Synonym: hydroxyl radical
Tree Number: T6.1.2.2.7
Tree Number: T6.1.7.2.3
database_cross_reference: CHV:0000014191
database_cross_reference: CSP:4003-0025
database_cross_reference: MSH:D017665
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C1130
database_cross_reference: NDFRT:N0000166219

Ammonium Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Ammonium Compounds
MCID: MC00020052
PMOID: PMO:00015203
Subclass_of: Ammonium Compounds
Subclass_of: Hydroxides
Synonym: AMMONIUM HYDROXIDE
Synonym: Ammonia water
Synonym: Ammonium Hydroxide [Chemical/Ingredient]
Synonym: Ammonium hydroxide
Synonym: Ammonium hydroxide (substance)
Synonym: Hydroxide, Ammonium
Synonym: ammonia water
Synonym: ammonium hydroxide
Tree Number: T6.1.2.2.8
Tree Number: T6.1.33.11.5
database_cross_reference: CHV:0000013480
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D064753
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NDDF:008846
database_cross_reference: NDFRT:N0000005888
database_cross_reference: NDFRT:N0000022628
database_cross_reference: RXNORM:1362884
database_cross_reference: SNM:E-5073
database_cross_reference: SNMI:C-10761
database_cross_reference: SNOMEDCT_US:76198002
database_cross_reference: VANDF:4020005

Lewis Bases
type: Class
subclass of: Alkalies
subclass of: Organic Chemicals
MCID: MC00224125
PMOID: PMO:00015204
Subclass_of: Alkalies
Subclass_of: Organic Chemicals
Synonym: Bases, Lewis
Synonym: Lewis Bases [Chemical/Ingredient]
Synonym: Lewis base
Tree Number: T6.1.2.3
Tree Number: T6.2.41
database_cross_reference: AOD:0000019568
database_cross_reference: MSH:D058115
database_cross_reference: NDFRT:N0000182067

Arsenicals
type: Class
subclass of: Inorganic Chemicals
subclass of: Organometallic Compounds
MCID: MC00001246
PMOID: PMO:00015205
Subclass_of: Inorganic Chemicals
Subclass_of: Organometallic Compounds
Synonym: ARSENIC CPDS
Synonym: Arsenic Compound
Synonym: Arsenic Compounds
Synonym: Arsenic compound
Synonym: Arsenic compound (substance)
Synonym: Arsenic compound, NOS
Synonym: Arsenic compounds
Synonym: Arsenicals [Chemical/Ingredient]
Synonym: Compounds, Arsenic
Synonym: arsenic compounds
Tree Number: T6.1.3
Tree Number: T6.2.28.5
database_cross_reference: CHV:0000001443
database_cross_reference: LCH_NW:sh85007453
database_cross_reference: MSH:D001152
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45557
database_cross_reference: NDFRT:N0000008120
database_cross_reference: SNMI:C-11510
database_cross_reference: SNOMEDCT_US:23217006

Arsenates
type: Class
subclass of: Arsenicals
MCID: MC00001243
PMOID: PMO:00015206
Subclass_of: Arsenicals
Synonym: Arsenates [Chemical/Ingredient]
Tree Number: T6.1.3.1
Tree Number: T6.2.28.5.3
database_cross_reference: LCH:U000360
database_cross_reference: LCH_NW:sh85007448
database_cross_reference: MSH:D001149
database_cross_reference: NDFRT:N0000166776

Arsenites
type: Class
subclass of: Arsenicals
MCID: MC00067433
PMOID: PMO:00015207
Subclass_of: Arsenicals
Synonym: Arsenites [Chemical/Ingredient]
Tree Number: T6.1.3.2
Tree Number: T6.2.28.5.10
database_cross_reference: MSH:D018053
database_cross_reference: NDFRT:N0000166773

Boron Compounds
type: Class
subclass of: Inorganic Chemicals
subclass of: Organic Chemicals
MCID: MC00001891
PMOID: PMO:00015208
Subclass_of: Inorganic Chemicals
Subclass_of: Organic Chemicals
Synonym: BORON CPDS
Synonym: Boron Compounds [Chemical/Ingredient]
Synonym: Boron compound
Synonym: Boron compound (substance)
Synonym: Boron compound, NOS
Synonym: Boron compounds
Synonym: Compounds, Boron
Tree Number: T6.1.4
Tree Number: T6.2.11
database_cross_reference: LCH_NW:sh89002772
database_cross_reference: MSH:D001896
database_cross_reference: NDFRT:N0000008253
database_cross_reference: SNMI:C-10910
database_cross_reference: SNOMEDCT_US:11555005

Boranes
type: Class
subclass of: Boron Compounds
MCID: MC00001878
PMOID: PMO:00015209
Subclass_of: Boron Compounds
Synonym: Borane
Synonym: Boranes [Chemical/Ingredient]
Synonym: Boron Hydrides
Synonym: Hydrides, Boron
Synonym: borane
Tree Number: T6.1.4.1
Tree Number: T6.2.11.1
database_cross_reference: CSP:1852-7336
database_cross_reference: LCH:U000645
database_cross_reference: LCH_NW:sh90001883
database_cross_reference: MSH:D001880
database_cross_reference: NDFRT:N0000166854

Borohydrides
type: Class
subclass of: Boranes
MCID: MC00001889
PMOID: PMO:00015210
Subclass_of: Boranes
Synonym: Borohydrides [Chemical/Ingredient]
Synonym: borohydride
Tree Number: T6.1.4.1.1
Tree Number: T6.2.11.1.1
database_cross_reference: CSP:1852-7336
database_cross_reference: MSH:D001894
database_cross_reference: NDFRT:N0000166855

Borates
type: Class
subclass of: Boric Acids
MCID: MC00001879
PMOID: PMO:00015211
Subclass_of: Boric Acids
Synonym: Borate
Synonym: Borate product
Synonym: Borate product (product)
Synonym: Borate product (substance)
Synonym: Borate salt
Synonym: Borate salt (substance)
Synonym: Borates [Chemical/Ingredient]
Synonym: borate
Synonym: borated
Synonym: borates
Tree Number: T6.1.4.2.1
Tree Number: T6.2.11.2.1
database_cross_reference: CHV:0000002091
database_cross_reference: LCH:U000646
database_cross_reference: LCH_NW:sh85015805
database_cross_reference: LNC:LP14927-5
database_cross_reference: LNC:MTHU001846
database_cross_reference: MSH:D001881
database_cross_reference: NDFRT:N0000007027
database_cross_reference: RCD:x01Jw
database_cross_reference: SNM:E-5092
database_cross_reference: SNMI:C-10920
database_cross_reference: SNOMEDCT_US:34074001
database_cross_reference: SNOMEDCT_US:350267000

Electrolytes
type: Class
subclass of: Inorganic Chemicals
MCID: MC00004347
PMOID: PMO:00015212
Subclass_of: Inorganic Chemicals
Synonym: ELECTROLYTE
Synonym: ELECTROLYTES
Synonym: Electrolyte
Synonym: Electrolyte (substance)
Synonym: Electrolyte, NOS
Synonym: Electrolytes [Chemical/Ingredient]
Synonym: electrolyte
Synonym: electrolytes
Synonym: electrolytes (medication)
Tree Number: T6.1.5
database_cross_reference: ATC:B05BB01
database_cross_reference: CCPSS:0031473
database_cross_reference: CHV:0000004340
database_cross_reference: CSP:1627-0882
database_cross_reference: GS:44438
database_cross_reference: GS:44529
database_cross_reference: GS:44534
database_cross_reference: GS:44535
database_cross_reference: GS:44606
database_cross_reference: GS:79077
database_cross_reference: GS:79078
database_cross_reference: LCH:U001534
database_cross_reference: LCH_NW:sh85042157
database_cross_reference: LNC:LP19403-2
database_cross_reference: LNC:MTHU008531
database_cross_reference: MEDCIN:41197
database_cross_reference: MEDLINEPLUS:4224
database_cross_reference: MMSL:10465
database_cross_reference: MMSL:20358
database_cross_reference: MSH:D004573
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C464
database_cross_reference: NCI_NCI-GLOSS:CDR0000044338
database_cross_reference: NDFRT:N0000008272
database_cross_reference: NDFRT:N0000020495
database_cross_reference: PSY:16540
database_cross_reference: RCD:X80Cx
database_cross_reference: SNMI:C-10010
database_cross_reference: SNOMEDCT_US:86355000
database_cross_reference: VANDF:4022490

Polyelectrolytes
type: Class
subclass of: Electrolytes
subclass of: Polymers
MCID: MC01054888
PMOID: PMO:00015213
Subclass_of: Electrolytes
Subclass_of: Polymers
Synonym: Polyelectrolytes [Chemical/Ingredient]
Tree Number: T6.1.5.1
Tree Number: T6.5.2.1
database_cross_reference: MSH:D000071228
database_cross_reference: NDFRT:N0000193173

Ions
type: Class
subclass of: Electrolytes
MCID: MC00007023
PMOID: PMO:00015214
Subclass_of: Electrolytes
Synonym: Ion
Synonym: Ion (substance)
Synonym: Ion, NOS
Synonym: Ions [Chemical/Ingredient]
Synonym: charged particles
Synonym: ion
Synonym: ions
Tree Number: T6.1.5.2
database_cross_reference: AOD:0000001096
database_cross_reference: AOD:0000021453
database_cross_reference: CHV:0000006908
database_cross_reference: CSP:1626-5132
database_cross_reference: LCH:U002504
database_cross_reference: LCH_NW:sh85067842
database_cross_reference: MSH:D007477
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C597
database_cross_reference: NCI_NCI-GLOSS:CDR0000643017
database_cross_reference: NDFRT:N0000008197
database_cross_reference: PSY:26580
database_cross_reference: RCD:XM0Eo
database_cross_reference: SNM:F-10020
database_cross_reference: SNMI:C-10001
database_cross_reference: SNOMEDCT_US:48006008

Anions
type: Class
subclass of: Ions
MCID: MC00000945
PMOID: PMO:00015215
Subclass_of: Ions
Synonym: Anion
Synonym: Anion (substance)
Synonym: Anions [Chemical/Ingredient]
Synonym: anion
Synonym: anions
Synonym: negatively charged particle
Tree Number: T6.1.5.2.1
database_cross_reference: AOD:0000001097
database_cross_reference: AOD:0000021455
database_cross_reference: CHV:0000001210
database_cross_reference: CSP:1626-7005
database_cross_reference: LCH:U000256
database_cross_reference: LCH_NW:sh85005295
database_cross_reference: MSH:D000838
database_cross_reference: NDFRT:N0000007541
database_cross_reference: RCD:Xa4gK
database_cross_reference: SNMI:C-10003
database_cross_reference: SNOMEDCT_US:47707009

Bromates
type: Class
subclass of: Bromine Compounds
MCID: MC00001949
PMOID: PMO:00015216
Subclass_of: Bromine Compounds
Synonym: Bromate
Synonym: Bromates [Chemical/Ingredient]
Synonym: bromate
Tree Number: T6.1.19.1
database_cross_reference: CHV:0000002168
database_cross_reference: LCH:U000682
database_cross_reference: LCH_NW:sh85017042
database_cross_reference: MMSL:9917
database_cross_reference: MSH:D001959
database_cross_reference: NDFRT:N0000166197
database_cross_reference: RXNORM:1748

Bromides
type: Class
subclass of: Hydrobromic Acid
MCID: MC00001954
PMOID: PMO:00015217
Subclass_of: Hydrobromic Acid
Synonym: Bromide
Synonym: Bromide salt
Synonym: Bromide salt (substance)
Synonym: Bromide salt, NOS
Synonym: Bromide, NOS
Synonym: Bromides [Chemical/Ingredient]
Synonym: br
Synonym: bromide
Synonym: bromide (Br)
Synonym: bromide salts
Tree Number: T6.1.19.2.1
database_cross_reference: ATC:N05CM11
database_cross_reference: CHV:0000002172
database_cross_reference: LCH:U000684
database_cross_reference: LCH_NW:sh85017050
database_cross_reference: LNC:LP14091-0
database_cross_reference: LNC:MTHU005164
database_cross_reference: MMSL:46577
database_cross_reference: MSH:D001965
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:001426
database_cross_reference: NDFRT:N0000166198
database_cross_reference: PSY:06990
database_cross_reference: RCD:X794y
database_cross_reference: SNM:E-5107
database_cross_reference: SNMI:C-11320
database_cross_reference: SNOMEDCT_US:16624005

Chlorates
type: Class
subclass of: Chlorine Compounds
MCID: MC00002637
PMOID: PMO:00015219
Subclass_of: Chlorine Compounds
Synonym: Chlorate
Synonym: Chlorates [Chemical/Ingredient]
Synonym: chlorate
Synonym: chlorates
Tree Number: T6.1.20.2
database_cross_reference: CHV:0000002816
database_cross_reference: LCH:U000967
database_cross_reference: LCH_NW:sh85024526
database_cross_reference: LNC:LP18050-2
database_cross_reference: LNC:MTHU003042
database_cross_reference: MSH:D002704
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166286

Chlorides
type: Class
subclass of: Hydrochloric Acid
MCID: MC00002648
PMOID: PMO:00015220
Subclass_of: Hydrochloric Acid
Synonym: Chloride
Synonym: Chloride salt
Synonym: Chloride salt (substance)
Synonym: Chloride salt, NOS
Synonym: Chloride, NOS
Synonym: Chlorides [Chemical/Ingredient]
Synonym: chloride salt
Synonym: chlorides
Tree Number: T6.1.20.4.1
database_cross_reference: AOD:0000002431
database_cross_reference: CHV:0000002823
database_cross_reference: LCH:U000971
database_cross_reference: LCH_NW:sh85024536
database_cross_reference: MSH:D002712
database_cross_reference: MTH:U000240
database_cross_reference: MTH:U001804
database_cross_reference: NDFRT:N0000007711
database_cross_reference: RCD:X80D1
database_cross_reference: SNM:E-5105
database_cross_reference: SNMI:C-11220
database_cross_reference: SNOMEDCT_US:50213009

Chromates
type: Class
subclass of: Chromium Compounds
MCID: MC00002804
PMOID: PMO:00015221
Subclass_of: Chromium Compounds
Synonym: CHROMATES
Synonym: Chromate
Synonym: Chromates [Chemical/Ingredient]
Synonym: chromate
Synonym: chromated
Synonym: chromates
Tree Number: T6.1.22.1
database_cross_reference: CHV:0000002924
database_cross_reference: LNC:LP30820-2
database_cross_reference: LNC:MTHU015325
database_cross_reference: MSH:D002840
database_cross_reference: NDFRT:N0000007919
database_cross_reference: NDFRT:N0000176169
database_cross_reference: VANDF:4027809

Cyanides
type: Class
subclass of: Hydrogen Cyanide
MCID: MC00003387
PMOID: PMO:00015222
Subclass_of: Hydrogen Cyanide
Synonym: Cyanide
Synonym: Cyanide (substance)
Synonym: Cyanides [Chemical/Ingredient]
Synonym: cyanide
Synonym: cyanides
Tree Number: T6.1.33.5.1
database_cross_reference: AOD:0000019601
database_cross_reference: CHV:0000003514
database_cross_reference: CSP:0774-4855
database_cross_reference: LCH:U001226
database_cross_reference: LCH_NW:sh85035028
database_cross_reference: LNC:LP16815-0
database_cross_reference: LNC:MTHU009326
database_cross_reference: MSH:D003486
database_cross_reference: MTH:U001836
database_cross_reference: NDFRT:N0000008185
database_cross_reference: RCD:X807f
database_cross_reference: SNOMEDCT_US:259102005

Ferricyanides
type: Class
subclass of: Ferric Compounds
MCID: MC00005041
PMOID: PMO:00015223
Subclass_of: Ferric Compounds
Synonym: Ferricyanides [Chemical/Ingredient]
Synonym: ferricyanide
Tree Number: T6.1.49.1.1
database_cross_reference: AOD:0000019606
database_cross_reference: CHV:0000004973
database_cross_reference: MSH:D005292
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007756

Ferrocyanides
type: Class
subclass of: Ferrous Compounds
MCID: MC00005049
PMOID: PMO:00015225
Subclass_of: Ferrous Compounds
Synonym: Ferrocyanides [Chemical/Ingredient]
Tree Number: T6.1.49.2.1
database_cross_reference: LCH:U001763
database_cross_reference: LCH_NW:sh85047876
database_cross_reference: MSH:D005295
database_cross_reference: NDFRT:N0000011441

Fluorides
type: Class
subclass of: Hydrofluoric Acid
MCID: MC00005192
PMOID: PMO:00015226
Subclass_of: Hydrofluoric Acid
Synonym: F-
Synonym: FLUORIDE
Synonym: FLUORIDE ION
Synonym: Fluoride
Synonym: Fluoride (substance)
Synonym: Fluoride Ion
Synonym: Fluoride ion
Synonym: Fluoride preparation
Synonym: Fluoride product
Synonym: Fluoride product (product)
Tree Number: T6.1.25.1.1
database_cross_reference: AOD:0000019580
database_cross_reference: CHV:0000005120
database_cross_reference: DRUGBANK:DB09325
database_cross_reference: DRUGBANK:DB09484
database_cross_reference: DRUGBANK:DB11257
database_cross_reference: LCH:U001828
database_cross_reference: LCH_NW:sh85049419
database_cross_reference: LNC:LP16818-4
database_cross_reference: LNC:MTHU003484
database_cross_reference: MMSL:4741
database_cross_reference: MMSL:d00428
database_cross_reference: MSH:D005459
database_cross_reference: MTH:U001930
database_cross_reference: NCI:C28149
database_cross_reference: NCI_CRCH:C28149
database_cross_reference: NCI_FDA:Q80VPU408O
database_cross_reference: NCI_NCI-GLOSS:CDR0000044670
database_cross_reference: NDDF:001102
database_cross_reference: NDFRT:N0000007067
database_cross_reference: NDFRT:N0000146047
database_cross_reference: RCD:Xa4gR
database_cross_reference: RCD:x01QE
database_cross_reference: SNM:E-5101
database_cross_reference: SNM:F-10280
database_cross_reference: SNMI:C-11111
database_cross_reference: SNOMEDCT_US:260778008
database_cross_reference: SNOMEDCT_US:290007002
database_cross_reference: SNOMEDCT_US:350594000
database_cross_reference: SNOMEDCT_US:372639009
database_cross_reference: SNOMEDCT_US:387415009
database_cross_reference: SNOMEDCT_US:73550007
database_cross_reference: USPMG:MTHU001738
database_cross_reference: VANDF:4017671

Iodates
type: Class
subclass of: Iodine Compounds
MCID: MC00006990
PMOID: PMO:00015227
Subclass_of: Iodine Compounds
Synonym: Iodates [Chemical/Ingredient]
Synonym: iodate
Synonym: iodates
Tree Number: T6.1.27.1
database_cross_reference: CHV:0000006896
database_cross_reference: LCH:U002495
database_cross_reference: LCH_NW:sh85067767
database_cross_reference: MSH:D007452
database_cross_reference: NDFRT:N0000166190

Iodides
type: Class
subclass of: Iodine Compounds
MCID: MC00006992
PMOID: PMO:00015228
Subclass_of: Iodine Compounds
Synonym: I - Iodide
Synonym: I-
Synonym: Iodide
Synonym: Iodide salt
Synonym: Iodide salt (substance)
Synonym: Iodide salt, NOS
Synonym: Iodide, NOS
Synonym: Iodides [Chemical/Ingredient]
Synonym: Iodine-
Synonym: iodide
Tree Number: T6.1.27.2
database_cross_reference: AOD:0000019582
database_cross_reference: CHV:0000006898
database_cross_reference: DRUGBANK:DB12754
database_cross_reference: LCH:U002496
database_cross_reference: LCH_NW:sh85067768
database_cross_reference: LNC:LP36777-8
database_cross_reference: LNC:MTHU020182
database_cross_reference: MMSL:5877
database_cross_reference: MMSL:7443
database_cross_reference: MSH:D007454
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C68255
database_cross_reference: NCI_CRCH:C68255
database_cross_reference: NDFRT:N0000007779
database_cross_reference: RCD:X80RF
database_cross_reference: SNMI:C-11420
database_cross_reference: SNOMEDCT_US:42146005

Nitrates
type: Class
subclass of: Nitric Acid
subclass of: Organic Chemicals
MCID: MC00008919
PMOID: PMO:00015229
Subclass_of: Nitric Acid
Subclass_of: Organic Chemicals
Synonym: Nitrate
Synonym: Nitrate salt
Synonym: Nitrate salt (substance)
Synonym: Nitrate salt, NOS
Synonym: Nitrates [Chemical/Ingredient]
Synonym: nitrate salts
Synonym: nitrates
Tree Number: T6.1.33.9.1
Tree Number: T6.2.22
database_cross_reference: AOD:0000018481
database_cross_reference: CHV:0000008730
database_cross_reference: LCH:U003239
database_cross_reference: LCH_NW:sh85092042
database_cross_reference: LNC:LP14269-2
database_cross_reference: LNC:MTHU003455
database_cross_reference: MSH:D009566
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C80487
database_cross_reference: NDDF:000693
database_cross_reference: NDFRT:N0000007647
database_cross_reference: RCD:Xa0ib
database_cross_reference: SNM:E-5078
database_cross_reference: SNMI:C-10740
database_cross_reference: SNOMEDCT_US:89119000

Nitrites
type: Class
subclass of: Nitrous Acid
subclass of: Organic Chemicals
MCID: MC00008926
PMOID: PMO:00015230
Subclass_of: Nitrous Acid
Subclass_of: Organic Chemicals
Synonym: Nitrite
Synonym: Nitrite salt
Synonym: Nitrite salt (substance)
Synonym: Nitrite salt, NOS
Synonym: Nitrites [Chemical/Ingredient]
Synonym: nitrite
Synonym: nitrites
Tree Number: T6.1.33.7.1
Tree Number: T6.2.24
database_cross_reference: AOD:0000018483
database_cross_reference: CHV:0000008735
database_cross_reference: CSP:2073-7856
database_cross_reference: DRUGBANK:DB12529
database_cross_reference: LCH:U003243
database_cross_reference: LCH_NW:sh85092056
database_cross_reference: MSH:D009573
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007649
database_cross_reference: SNM:E-5077
database_cross_reference: SNMI:C-10731
database_cross_reference: SNOMEDCT_US:31528005

Oxides
type: Class
subclass of: Oxygen Compounds
MCID: MC00009567
PMOID: PMO:00015231
Subclass_of: Oxygen Compounds
Synonym: Oxides (substance)
Synonym: Oxides [Chemical/Ingredient]
Synonym: oxide
Synonym: oxides
Tree Number: T6.1.18.1
database_cross_reference: AOD:0000019609
database_cross_reference: CHV:0000009146
database_cross_reference: CSP:2165-9372
database_cross_reference: LCH:U003422
database_cross_reference: LCH_NW:sh85096314
database_cross_reference: MSH:D010087
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007842
database_cross_reference: RCD:XM0Ee
database_cross_reference: SNOMEDCT_US:272156001

Peroxides
type: Class
subclass of: Oxides
subclass of: Free Radicals
subclass of: Reactive Oxygen Species
MCID: MC00009951
PMOID: PMO:00015232
Subclass_of: Free Radicals
Subclass_of: Oxides
Subclass_of: Reactive Oxygen Species
Synonym: PEROXIDE
Synonym: Peroxide
Synonym: Peroxide (substance)
Synonym: Peroxides [Chemical/Ingredient]
Synonym: peroxide
Synonym: peroxides
Tree Number: T6.1.18.1.8
Tree Number: T6.1.7.2.2
Tree Number: T6.2.15.1
database_cross_reference: AOD:0000019631
database_cross_reference: CCPSS:0044542
database_cross_reference: CHV:0000009537
database_cross_reference: CSP:2251-5333
database_cross_reference: LCH:U003576
database_cross_reference: LCH_NW:sh85100033
database_cross_reference: MSH:D010545
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008023
database_cross_reference: SNOMEDCT_US:418339008

Hydrogen Peroxide
type: Class
subclass of: Peroxides
MCID: MC00006469
PMOID: PMO:00015233
Subclass_of: Peroxides
Synonym: 3% Hydrogen Peroxide Well at Walgreens
Synonym: Aplicare Hydrogen Peroxide
Synonym: Blossom HP 3
Synonym: CURAD Hydrogen Peroxide
Synonym: DOP Hydrogen Peroxide 3%
Synonym: Dihydrogen Dioxide
Synonym: Dihydrogen Peroxide
Synonym: Dio Whitening
Synonym: Dynarex HP 3
Synonym: ECOLAB Hydrogen Peroxide
Tree Number: T6.2.15.1.1
database_cross_reference: ATC:A01AB02
database_cross_reference: ATC:D08AX01
database_cross_reference: ATC:S02AA06
database_cross_reference: CHV:0000006356
database_cross_reference: CSP:2251-6269
database_cross_reference: DRUGBANK:DB11091
database_cross_reference: LCH:U002279
database_cross_reference: LCH_NW:sh85063431
database_cross_reference: MEDCIN:309056
database_cross_reference: MEDCIN:41345
database_cross_reference: MMSL:35389
database_cross_reference: MMSL:35390
database_cross_reference: MMSL:4847
database_cross_reference: MMSL:5359
database_cross_reference: MSH:D006861
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:BBX060AN9V
database_cross_reference: NCI:C28156
database_cross_reference: NCI_DCP:00829
database_cross_reference: NCI_FDA:BBX060AN9V
database_cross_reference: NCI_NCI-GLOSS:CDR0000044113
database_cross_reference: NDDF:003157
database_cross_reference: NDFRT:N0000006490
database_cross_reference: NDFRT:N0000147686
database_cross_reference: RCD:XM0lZ
database_cross_reference: RCD:le4..
database_cross_reference: RCD:mib..
database_cross_reference: RCD:x02Mb
database_cross_reference: RXNORM:5499
database_cross_reference: SNM:E-7116
database_cross_reference: SNMI:C-96010
database_cross_reference: SNOMEDCT_US:273956008
database_cross_reference: SNOMEDCT_US:31231007
database_cross_reference: SNOMEDCT_US:331301001
database_cross_reference: SNOMEDCT_US:333301006
database_cross_reference: SNOMEDCT_US:387171003
database_cross_reference: VANDF:4019590

Lipid Peroxides
type: Class
subclass of: Peroxides
subclass of: PMO:00021062
MCID: MC00007591
PMOID: PMO:00015234
Subclass_of: Lipids
Subclass_of: Peroxides
Synonym: Acid Hydroperoxides, Fatty
Synonym: Fatty Acid Hydroperoxides
Synonym: HO2R
Synonym: Hydroperoxide, Lipid
Synonym: Hydroperoxides, Fatty Acid
Synonym: LOOH
Synonym: LPO
Synonym: Lipid Hydroperoxide
Synonym: Lipid Peroxides [Chemical/Ingredient]
Synonym: Lipoperoxides
Tree Number: T6.2.15.1.2
Tree Number: T6.9.7
database_cross_reference: CHV:0000007453
database_cross_reference: CSP:1744-1137
database_cross_reference: MSH:D008054
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124072
database_cross_reference: NDFRT:N0000168561

Prostaglandin Endoperoxides
type: Class
subclass of: Peroxides
MCID: MC00010739
PMOID: PMO:00015235
Subclass_of: Peroxides
Synonym: Endoperoxides, Prostaglandin
Synonym: PG ENDOPEROXIDES
Synonym: Prostaglandin Endoperoxides [Chemical/Ingredient]
Synonym: prostaglandin endoperoxide
Tree Number: T6.2.15.1.3
database_cross_reference: AOD:0000020053
database_cross_reference: MSH:D011449
database_cross_reference: NDFRT:N0000171026

Superoxides
type: Class
subclass of: Peroxides
MCID: MC00012435
PMOID: PMO:00015240
Subclass_of: Peroxides
Synonym: Superoxide
Synonym: Superoxide Anion
Synonym: Superoxide Radical
Synonym: Superoxides [Chemical/Ingredient]
Synonym: superoxide
Synonym: superoxide anion
Synonym: superoxide radical
Tree Number: T6.2.15.1.4
database_cross_reference: AOD:0000001291
database_cross_reference: AOD:0000001292
database_cross_reference: CHV:0000011894
database_cross_reference: CSP:2166-1558
database_cross_reference: LCH:U004530
database_cross_reference: LCH_NW:sh85130640
database_cross_reference: MSH:D013481
database_cross_reference: NCI:C852
database_cross_reference: NDFRT:N0000166189

tert-Butylhydroperoxide
type: Class
subclass of: Peroxides
MCID: MC00038965
PMOID: PMO:00015241
Subclass_of: Peroxides
Synonym: BUTYL HYDROPEROXIDE T
Synonym: Hydroperoxide, 1,1-dimethylethyl
Synonym: Hydroperoxide, t-Butyl
Synonym: Hydroperoxide, tert-Butyl
Synonym: t Butyl Hydroperoxide
Synonym: t Butylhydroperoxide
Synonym: t-Butyl Hydroperoxide
Synonym: t-Butylhydroperoxide
Synonym: tert Butyl Hydroperoxide
Synonym: tert Butylhydroperoxide
Tree Number: T6.2.15.1.5
database_cross_reference: MSH:D020122
database_cross_reference: NDFRT:N0000166626

Artemisinins
type: Class
subclass of: Peroxides
MCID: MC00377871
PMOID: PMO:00015242
Subclass_of: Peroxides
Synonym: Artemisinin
Synonym: Artemisinins [Chemical/Ingredient]
Synonym: artemisinins
Tree Number: T6.2.15.1.6
database_cross_reference: CHV:0000054942
database_cross_reference: DRUGBANK:DB13132
database_cross_reference: LCH_NW:sh2007003203
database_cross_reference: MSH:D037621
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166625

Tetraoxanes
type: Class
subclass of: Peroxides
PMOID: PMO:00015243
Subclass_of: Peroxides
Tree Number: T6.2.15.1.7

Sulfides
type: Class
subclass of: Hydrogen Sulfide
subclass of: Sulfur Compounds
MCID: MC00012389
PMOID: PMO:00015246
Subclass_of: Hydrogen Sulfide
Subclass_of: Sulfur Compounds
Synonym: Sulfide
Synonym: Sulfide (substance)
Synonym: Sulfides [Chemical/Ingredient]
Synonym: Sulphide
Synonym: sulfide
Synonym: sulfides
Synonym: sulphide
Synonym: sulphides
Tree Number: T6.1.13.1.1
Tree Number: T6.2.32.7
database_cross_reference: AOD:0000019638
database_cross_reference: CHV:0000011862
database_cross_reference: CSP:2837-0331
database_cross_reference: LCH_NW:sh85130342
database_cross_reference: LNC:LP17951-2
database_cross_reference: LNC:MTHU007719
database_cross_reference: MSH:D013440
database_cross_reference: NDFRT:N0000008042
database_cross_reference: SNOMEDCT_US:116252005

Disulfides
type: Class
subclass of: Sulfides
MCID: MC00004069
PMOID: PMO:00015247
Subclass_of: Sulfides
Synonym: Disulfides [Chemical/Ingredient]
Synonym: disulfide
Synonym: disulfides
Tree Number: T6.2.32.7.1
database_cross_reference: CHV:0000004041
database_cross_reference: MSH:D004220
database_cross_reference: NDFRT:N0000007877

Cystine
type: Class
subclass of: PMO:00021283
subclass of: PMO:00021298
MCID: MC00003472
PMOID: PMO:00015248
Subclass_of: Amino Acids, Diamino
Subclass_of: Amino Acids, Dicarboxylic
Synonym: (2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoic acid)
Synonym: (R,R)-3,3'-dithiobis(2-aminopropanoic acid)
Synonym: (R-(R*,R*))-3,3'-Dithiobis(2-Aminopropanoic Acid)
Synonym: 1-Cystine
Synonym: 3,3'-Dithiobis(2-Aminopropanoic Acid)
Synonym: 3,3'-Dithiobis(2-Aminopropanoic Acid), (R-(R*,R*))-
Synonym: 3,3'-Dithiodialanine
Synonym: Alanine, 3,3'-Dithiobis-
Synonym: Alanine, 3,3'-Dithiodi-
Synonym: Beta,Beta'-Diamino-Beta,Beta'-Dicarboxydiethyl Disulfide
Tree Number: T6.10.1.5.5
Tree Number: T6.10.1.6.4
database_cross_reference: AOD:0000020257
database_cross_reference: CHV:0000003555
database_cross_reference: CSP:2842-7411
database_cross_reference: DRUGBANK:DB00138
database_cross_reference: LNC:LP14976-2
database_cross_reference: LNC:MTHU004102
database_cross_reference: MEDCIN:199253
database_cross_reference: MMSL:4525
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D003553
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:48TCX9A1VT
database_cross_reference: NCI:C29610
database_cross_reference: NCI_DCP:02778
database_cross_reference: NCI_FDA:48TCX9A1VT
database_cross_reference: NDDF:005113
database_cross_reference: NDFRT:N0000006059
database_cross_reference: NDFRT:N0000147293
database_cross_reference: RCD:X807F
database_cross_reference: RCD:XaDdK
database_cross_reference: RXNORM:3036
database_cross_reference: SNM:F-14390
database_cross_reference: SNMI:F-64190
database_cross_reference: SNOMEDCT_US:312174006
database_cross_reference: SNOMEDCT_US:37927000
database_cross_reference: VANDF:4019019

Sulfites
type: Class
subclass of: Sulfur Compounds
MCID: MC00012398
PMOID: PMO:00015249
Subclass_of: Sulfur Compounds
Synonym: INORG SULFITES
Synonym: Inorganic Sulfites
Synonym: SULFITES INORG
Synonym: Sulfite
Synonym: Sulfite salt
Synonym: Sulfite salt (substance)
Synonym: Sulfite salt, NOS
Synonym: Sulfites [Chemical/Ingredient]
Synonym: Sulfites, Inorganic
Synonym: Sulphite
Tree Number: T6.1.13.2
database_cross_reference: AOD:0000018504
database_cross_reference: CHV:0000011865
database_cross_reference: CSP:2838-5315
database_cross_reference: LNC:LP99342-5
database_cross_reference: LNC:MTHU035518
database_cross_reference: MSH:D013447
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:006300
database_cross_reference: NDFRT:N0000008046
database_cross_reference: RCD:X80MA
database_cross_reference: RCDAE:X80MA
database_cross_reference: SNM:E-5087
database_cross_reference: SNMI:C-10831
database_cross_reference: SNOMEDCT_US:51963001

Dithionite
type: Class
subclass of: Sulfites
MCID: MC00004077
PMOID: PMO:00015250
Subclass_of: Sulfites
Synonym: Dithionite [Chemical/Ingredient]
Synonym: Hyposulfite
Tree Number: T6.1.13.2.1
database_cross_reference: MSH:D004227
database_cross_reference: NDFRT:N0000166207

Vanadates
type: Class
subclass of: Vanadium Compounds
MCID: MC00013469
PMOID: PMO:00015251
Subclass_of: Vanadium Compounds
Synonym: Vanadate
Synonym: Vanadates [Chemical/Ingredient]
Synonym: vanadate
Tree Number: T6.1.38.1
database_cross_reference: CHV:0000012889
database_cross_reference: CSP:1852-9180
database_cross_reference: LCH:U004893
database_cross_reference: LCH_NW:sh85142004
database_cross_reference: MSH:D014638
database_cross_reference: NDFRT:N0000166279

Cations
type: Class
subclass of: Ions
MCID: MC00002389
PMOID: PMO:00015253
Subclass_of: Ions
Synonym: Cation
Synonym: Cation (substance)
Synonym: Cations [Chemical/Ingredient]
Synonym: cation
Synonym: cations
Synonym: positively charged particle
Tree Number: T6.1.5.2.2
database_cross_reference: AOD:0000001098
database_cross_reference: AOD:0000021457
database_cross_reference: CHV:0000002541
database_cross_reference: CSP:1627-0751
database_cross_reference: LCH:U000850
database_cross_reference: LCH_NW:sh85021247
database_cross_reference: MSH:D002412
database_cross_reference: NDFRT:N0000166191
database_cross_reference: RCD:Xa4gJ
database_cross_reference: SNMI:C-10002
database_cross_reference: SNOMEDCT_US:31046007

Protons
type: Class
subclass of: Hydrogen
MCID: MC00010809
PMOID: PMO:00015256
Subclass_of: Hydrogen
Synonym: H+
Synonym: H+ element
Synonym: H^+^
Synonym: Hydrogen Ion
Synonym: Hydrogen Ions
Synonym: Hydrogen ion
Synonym: Ion, Hydrogen
Synonym: Ions, Hydrogen
Synonym: Proton
Tree Number: T6.1.6.5.2
Tree Number: T6.1.8.7.2
database_cross_reference: AOD:0000001091
database_cross_reference: CHV:0000010262
database_cross_reference: CSP:4007-0059
database_cross_reference: LCH:U003885
database_cross_reference: LCH_NW:sh85107796
database_cross_reference: LNC:LA4665-1
database_cross_reference: LNC:LP33343-2
database_cross_reference: LNC:MTHU016661
database_cross_reference: MSH:D011522
database_cross_reference: MTH:U002198
database_cross_reference: NCI:C17024
database_cross_reference: NCI_NCI-GLOSS:CDR0000044715
database_cross_reference: NDFRT:N0000166194
database_cross_reference: RCD:X79Of
database_cross_reference: SNM:E-9334
database_cross_reference: SNM:F-10300
database_cross_reference: SNMI:C-10005
database_cross_reference: SNOMEDCT_US:123228009
database_cross_reference: SNOMEDCT_US:89177007

Elements
type: Class
subclass of: Inorganic Chemicals
MCID: MC00004352
PMOID: PMO:00015257
Subclass_of: Inorganic Chemicals
Synonym: Chemical Elements
Synonym: Chemical element
Synonym: Chemical element (substance)
Synonym: Chemical element, NOS
Synonym: Chemical elements
Synonym: Element
Synonym: Element, NOS
Synonym: Element, chemical
Synonym: Elements [Chemical/Ingredient]
Synonym: chemical elements
Tree Number: T6.1.6
database_cross_reference: AOD:0000019447
database_cross_reference: CHV:0000004360
database_cross_reference: CSP:0631-2320
database_cross_reference: LCH:U005508
database_cross_reference: LCH_NW:sh85022897
database_cross_reference: MSH:D004602
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C1940
database_cross_reference: NCI_NCI-GLOSS:CDR0000613508
database_cross_reference: NDFRT:N0000007912
database_cross_reference: PSY:08550
database_cross_reference: RCD:XM0EY
database_cross_reference: SNM:E-5001
database_cross_reference: SNMI:C-10000
database_cross_reference: SNOMEDCT_US:57795002

Carbon
type: Class
subclass of: Elements
MCID: MC00002234
PMOID: PMO:00015258
Subclass_of: Elements
Synonym: C element
Synonym: Carbon (substance)
Synonym: Carbon [Chemical/Ingredient]
Synonym: Carbon, NOS
Synonym: Elemental Carbon
Synonym: carbon
Synonym: carbons
Tree Number: T6.1.6.1
database_cross_reference: AOD:0000001960
database_cross_reference: CHV:0000002391
database_cross_reference: CSP:0552-0356
database_cross_reference: CSP:4007-0020
database_cross_reference: DRUGBANK:DB09278
database_cross_reference: LCH:U000784
database_cross_reference: LCH_NW:sh85020090
database_cross_reference: MSH:D002244
database_cross_reference: NCI:C63798
database_cross_reference: NDFRT:N0000007500
database_cross_reference: PSY:07520
database_cross_reference: RCD:Xa1gj
database_cross_reference: SNM:E-5050
database_cross_reference: SNMI:C-10500
database_cross_reference: SNOMEDCT_US:87453002

Carbon Isotopes
type: Class
subclass of: Carbon
subclass of: Isotopes
MCID: MC00002239
PMOID: PMO:00015259
Subclass_of: Carbon
Subclass_of: Isotopes
Synonym: Carbon Isotopes [Chemical/Ingredient]
Synonym: Carbon isotope
Synonym: Carbon isotope (substance)
Synonym: Carbon--Isotopes
Synonym: Isotopes, Carbon
Tree Number: T6.1.6.1.1
Tree Number: T6.1.9.2
database_cross_reference: LCH_NW:sh85020091
database_cross_reference: MSH:D002247
database_cross_reference: NDFRT:N0000166117
database_cross_reference: SNMI:C-10501
database_cross_reference: SNOMEDCT_US:31947001

Carbon Radioisotopes
type: Class
subclass of: Carbon Isotopes
subclass of: Radioisotopes
MCID: MC00002241
PMOID: PMO:00015260
Subclass_of: Carbon Isotopes
Subclass_of: Radioisotopes
Synonym: Carbon Radioisotopes [Chemical/Ingredient]
Synonym: Carbon radioisotope
Synonym: Carbon radioisotope (substance)
Synonym: Carbon radioisotope, NOS
Synonym: Radioisotopes, Carbon
Tree Number: T6.1.9.17.5
Tree Number: T6.1.9.2.1
database_cross_reference: MSH:D002250
database_cross_reference: NDFRT:N0000166118
database_cross_reference: SNM:E-5052
database_cross_reference: SNMI:C-105A0
database_cross_reference: SNOMEDCT_US:90355009

Charcoal
type: Class
subclass of: Carbon
MCID: MC00002588
PMOID: PMO:00015261
Subclass_of: Carbon
Synonym: CHARCOAL
Synonym: Charcoal [Chemical/Ingredient]
Synonym: charcoal
Tree Number: T6.1.6.1.2
database_cross_reference: CHV:0000002721
database_cross_reference: CSP:4007-0027
database_cross_reference: DRUGBANK:DB09278
database_cross_reference: LCH:U000926
database_cross_reference: LCH_NW:sh85022633
database_cross_reference: LNC:LA12905-8
database_cross_reference: LNC:LP65027-2
database_cross_reference: LNC:MTHU026680
database_cross_reference: MMSL:4402
database_cross_reference: MMSL:6014
database_cross_reference: MMSL:d01028
database_cross_reference: MSH:D002606
database_cross_reference: NDFRT:N0000005865
database_cross_reference: NDFRT:N0000147348
database_cross_reference: RXNORM:2296
database_cross_reference: VANDF:4019088

Graphite
type: Class
subclass of: Carbon
subclass of: Minerals
PMOID: PMO:00015262
Subclass_of: Carbon
Subclass_of: Minerals
Tree Number: T6.1.11.4
Tree Number: T6.1.6.1.3

Diamond
type: Class
subclass of: Carbon
MCID: MC00024691
PMOID: PMO:00015263
Subclass_of: Carbon
Synonym: DIAMOND
Synonym: Diamond (substance)
Synonym: Diamond [Chemical/Ingredient]
Synonym: Diamonds
Synonym: diamond
Synonym: diamonds
Tree Number: T6.1.6.1.4
database_cross_reference: CHV:0000013863
database_cross_reference: LCH_NW:sh85037566
database_cross_reference: MSH:D018130
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:6GRV67N0U2
database_cross_reference: NDFRT:N0000166169
database_cross_reference: RXNORM:1362686
database_cross_reference: SNMI:C-10504
database_cross_reference: SNOMEDCT_US:1726000

Fullerenes
type: Class
subclass of: Carbon
MCID: MC00106483
PMOID: PMO:00015265
Subclass_of: Carbon
Synonym: Buckminsterfullerene
Synonym: Buckminsterfullerenes
Synonym: Buckyball
Synonym: Buckyballs
Synonym: Fullerene
Synonym: Fullerene (substance)
Synonym: Fullerenes [Chemical/Ingredient]
Synonym: buckminsterfullerene
Synonym: buckyballs
Synonym: fullerene
Tree Number: T6.1.6.1.5
database_cross_reference: CHV:0000028025
database_cross_reference: LCH_NW:sh91005662
database_cross_reference: MSH:D037741
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C62382
database_cross_reference: NDFRT:N0000166167
database_cross_reference: SNMI:C-10505
database_cross_reference: SNOMEDCT_US:77433007

Elements, Radioactive
type: Class
subclass of: Elements
subclass of: Radioisotopes
MCID: MC00004353
PMOID: PMO:00015267
Subclass_of: Elements
Subclass_of: Radioisotopes
Synonym: Elements, Radioactive [Chemical/Ingredient]
Synonym: Elements, radioactive
Synonym: Radioactive Element
Synonym: Radioactive Elements
Tree Number: T6.1.6.2
Tree Number: T6.1.9.17.11
database_cross_reference: MSH:D004603
database_cross_reference: NCI:C465
database_cross_reference: NDFRT:N0000007913

Transactinide Series Elements
type: Class
subclass of: Elements, Radioactive
PMOID: PMO:00015268
Subclass_of: Elements, Radioactive
Tree Number: T6.1.6.2.1

Astatine
type: Class
subclass of: Elements, Radioactive
subclass of: Halogens
MCID: MC00001326
PMOID: PMO:00015269
Subclass_of: Elements, Radioactive
Subclass_of: Halogens
Synonym: Astatine [Chemical/Ingredient]
Synonym: astatine
Tree Number: T6.1.6.2.2
Tree Number: T6.1.6.4.1
database_cross_reference: AOD:0000019492
database_cross_reference: LCH:U000402
database_cross_reference: LCH_NW:sh85008844
database_cross_reference: MSH:D001246
database_cross_reference: NDFRT:N0000166178

Bismuth
type: Class
subclass of: Elements, Radioactive
subclass of: Metals, Heavy
MCID: MC00001775
PMOID: PMO:00015270
Subclass_of: Elements, Radioactive
Subclass_of: Metals, Heavy
Synonym: BISMUTH
Synonym: Bi
Synonym: Bi - Bismuth
Synonym: Bi element
Synonym: Bismuth (substance)
Synonym: Bismuth Metallicum
Synonym: Bismuth [Chemical/Ingredient]
Synonym: Bismuth, NOS
Synonym: bismuth
Tree Number: T6.1.10.6.6
Tree Number: T6.1.6.12.6
Tree Number: T6.1.6.2.3
database_cross_reference: AOD:0000019481
database_cross_reference: CHV:0000001935
database_cross_reference: CSP:1852-9415
database_cross_reference: DRUGBANK:DB01294
database_cross_reference: LCH:U000593
database_cross_reference: LCH_NW:sh85014436
database_cross_reference: LNC:LP16806-9
database_cross_reference: LNC:MTHU006824
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D001729
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:U015TT5I8H
database_cross_reference: NCI:C95193
database_cross_reference: NCI_FDA:U015TT5I8H
database_cross_reference: NDDF:001158
database_cross_reference: NDFRT:N0000007888
database_cross_reference: NDFRT:N0000148861
database_cross_reference: RCD:X794w
database_cross_reference: RXNORM:1599
database_cross_reference: SNMI:C-12500
database_cross_reference: SNOMEDCT_US:23172004
database_cross_reference: VANDF:4021482

Francium
type: Class
subclass of: Elements, Radioactive
subclass of: Metals, Alkali
subclass of: Metals, Heavy
MCID: MC00005294
PMOID: PMO:00015271
Subclass_of: Elements, Radioactive
Subclass_of: Metals, Alkali
Subclass_of: Metals, Heavy
Synonym: Francium [Chemical/Ingredient]
Synonym: francium
Tree Number: T6.1.10.3.2
Tree Number: T6.1.10.6.16
Tree Number: T6.1.6.12.16
Tree Number: T6.1.6.2.4
Tree Number: T6.1.6.6.2
database_cross_reference: AOD:0000019457
database_cross_reference: LCH:U001875
database_cross_reference: LCH_NW:sh85051541
database_cross_reference: MSH:D005605
database_cross_reference: NDFRT:N0000166246

Actinoid Series Elements
type: Class
subclass of: Elements, Radioactive
subclass of: Metals
MCID: MC00008135
PMOID: PMO:00015272
Subclass_of: Elements, Radioactive
Subclass_of: Metals
Synonym: Actinide Metals
Synonym: Actinides
Synonym: Actinoid Metals
Synonym: Actinoid Series Elements [Chemical/Ingredient]
Synonym: Actinoids
Synonym: Elements, Actinoid Series
Synonym: Metals, Actinide
Synonym: Metals, Actinoid
Synonym: actinide
Tree Number: T6.1.10.2
Tree Number: T6.1.6.2.5
database_cross_reference: CSP:2540-7596
database_cross_reference: MSH:D008671
database_cross_reference: NDFRT:N0000166223

Actinium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00000288
PMOID: PMO:00015273
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Ac element
Synonym: Actinium
Synonym: Actinium (substance)
Synonym: Actinium [Chemical/Ingredient]
Synonym: Actinium, NOS
Synonym: actinium
Tree Number: T6.1.10.2.1
Tree Number: T6.1.10.6.1
Tree Number: T6.1.6.12.1
database_cross_reference: CSP:2540-7596
database_cross_reference: DRUGBANK:DB00776
database_cross_reference: DRUGBANK:DB12860
database_cross_reference: LCH:U000049
database_cross_reference: LCH_NW:sh85000706
database_cross_reference: MSH:D000186
database_cross_reference: NDFRT:N0000166262
database_cross_reference: SNMI:C-11900
database_cross_reference: SNOMEDCT_US:1396009

Americium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00000713
PMOID: PMO:00015274
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: AMERICIUM
Synonym: Am
Synonym: Am element
Synonym: Americium (substance)
Synonym: Americium [Chemical/Ingredient]
Synonym: Americium, NOS
Synonym: Americum, NOS
Synonym: americium
Tree Number: T6.1.10.2.2
Tree Number: T6.1.10.6.2
Tree Number: T6.1.6.12.2
database_cross_reference: AOD:0000019554
database_cross_reference: CSP:2540-7689
database_cross_reference: LCH:U000186
database_cross_reference: LCH_NW:sh85004443
database_cross_reference: MSH:D000576
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C229
database_cross_reference: NCI_FDA:VW92PHU2UY
database_cross_reference: NDFRT:N0000166269
database_cross_reference: SNMI:C-17900
database_cross_reference: SNOMEDCT_US:88781006

Berkelium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00001622
PMOID: PMO:00015275
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Berkelium [Chemical/Ingredient]
Synonym: berkelium
Tree Number: T6.1.10.2.3
Tree Number: T6.1.10.6.5
Tree Number: T6.1.6.12.5
database_cross_reference: AOD:0000019556
database_cross_reference: DRUGBANK:DB12993
database_cross_reference: LCH_NW:sh2012004283
database_cross_reference: MSH:D001603
database_cross_reference: NDFRT:N0000166263

Californium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00002150
PMOID: PMO:00015276
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Californium (substance)
Synonym: Californium [Chemical/Ingredient]
Synonym: Californium, NOS
Synonym: californium
Tree Number: T6.1.10.2.4
Tree Number: T6.1.10.6.8
Tree Number: T6.1.6.12.8
database_cross_reference: AOD:0000019557
database_cross_reference: CSP:2540-7596
database_cross_reference: LCH_NW:sh89004338
database_cross_reference: MSH:D002142
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166252
database_cross_reference: SNMI:C-12400
database_cross_reference: SNOMEDCT_US:12292006

Curium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00003375
PMOID: PMO:00015277
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Curium (substance)
Synonym: Curium [Chemical/Ingredient]
Synonym: curium
Tree Number: T6.1.10.2.5
Tree Number: T6.1.10.6.13
Tree Number: T6.1.6.12.13
database_cross_reference: AOD:0000019555
database_cross_reference: LCH:U001223
database_cross_reference: LCH_NW:sh85034863
database_cross_reference: MSH:D003476
database_cross_reference: NDFRT:N0000166259
database_cross_reference: SNOMEDCT_US:416918003

Einsteinium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00004334
PMOID: PMO:00015278
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Einsteinium [Chemical/Ingredient]
Synonym: einsteinium
Tree Number: T6.1.10.2.6
Tree Number: T6.1.10.6.14
Tree Number: T6.1.6.12.14
database_cross_reference: AOD:0000019558
database_cross_reference: MSH:D004540
database_cross_reference: NDFRT:N0000166242

Fermium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00005034
PMOID: PMO:00015279
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Fermium [Chemical/Ingredient]
Synonym: fermium
Tree Number: T6.1.10.2.7
Tree Number: T6.1.10.6.15
Tree Number: T6.1.6.12.15
database_cross_reference: AOD:0000019559
database_cross_reference: LCH_NW:sh2012003995
database_cross_reference: MSH:D005286
database_cross_reference: NDFRT:N0000166271

Lawrencium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00007401
PMOID: PMO:00015280
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Lawrencium [Chemical/Ingredient]
Synonym: lawrencium
Tree Number: T6.1.10.2.8
Tree Number: T6.1.10.6.24
Tree Number: T6.1.6.12.24
Tree Number: T6.1.6.14.9
database_cross_reference: AOD:0000019562
database_cross_reference: DRUGBANK:DB12599
database_cross_reference: LCH:U002636
database_cross_reference: LCH_NW:sh85075345
database_cross_reference: MSH:D007852
database_cross_reference: NDFRT:N0000166245

Mendelevium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00008033
PMOID: PMO:00015281
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Mendelevium [Chemical/Ingredient]
Synonym: mendelevium
Tree Number: T6.1.10.2.9
Tree Number: T6.1.10.6.27
Tree Number: T6.1.6.12.27
database_cross_reference: AOD:0000019560
database_cross_reference: LCH_NW:sh2012003626
database_cross_reference: MSH:D008573
database_cross_reference: NDFRT:N0000166253

Neptunium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00008778
PMOID: PMO:00015282
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Neptunium [Chemical/Ingredient]
Synonym: neptunium
Tree Number: T6.1.10.2.10
Tree Number: T6.1.10.6.30
Tree Number: T6.1.6.12.30
database_cross_reference: AOD:0000019552
database_cross_reference: LCH:U003159
database_cross_reference: LCH_NW:sh85090879
database_cross_reference: MSH:D009405
database_cross_reference: NDFRT:N0000166248

Nobelium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00008970
PMOID: PMO:00015283
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Nobelium [Chemical/Ingredient]
Synonym: nobelium
Tree Number: T6.1.10.2.11
Tree Number: T6.1.10.6.33
Tree Number: T6.1.6.12.33
database_cross_reference: AOD:0000019561
database_cross_reference: LCH_NW:sh2012003649
database_cross_reference: MSH:D009614
database_cross_reference: NDFRT:N0000166258

Plutonium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00010343
PMOID: PMO:00015284
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: PLUTONIUM
Synonym: Plutonium (substance)
Synonym: Plutonium [Chemical/Ingredient]
Synonym: Plutonium, NOS
Synonym: Pu element
Synonym: plutonium
Tree Number: T6.1.10.2.12
Tree Number: T6.1.10.6.37
Tree Number: T6.1.6.12.37
database_cross_reference: AOD:0000019553
database_cross_reference: CHV:0000009859
database_cross_reference: CSP:2540-7947
database_cross_reference: LCH:U003726
database_cross_reference: LCH_NW:sh85103582
database_cross_reference: LNC:LP19200-2
database_cross_reference: LNC:MTHU007565
database_cross_reference: MSH:D011005
database_cross_reference: MTHSPL:53023GN24M
database_cross_reference: NDFRT:N0000166260
database_cross_reference: RCD:Xa9gB
database_cross_reference: RXNORM:1600135
database_cross_reference: SNMI:C-16100
database_cross_reference: SNOMEDCT_US:38327007

Protactinium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00010763
PMOID: PMO:00015285
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Protactinium [Chemical/Ingredient]
Synonym: protactinium
Tree Number: T6.1.10.2.13
Tree Number: T6.1.10.6.38
Tree Number: T6.1.6.12.38
database_cross_reference: AOD:0000019549
database_cross_reference: LCH:U003872
database_cross_reference: LCH_NW:sh85107634
database_cross_reference: MSH:D011478
database_cross_reference: NDFRT:N0000166274

Thorium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00012776
PMOID: PMO:00015286
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: THORIUM
Synonym: Th - Thorium
Synonym: Thorium (substance)
Synonym: Thorium [Chemical/Ingredient]
Synonym: Thorium, NOS
Synonym: thorium
Tree Number: T6.1.10.2.14
Tree Number: T6.1.10.6.49
Tree Number: T6.1.6.12.49
database_cross_reference: AOD:0000019547
database_cross_reference: CHV:0000012215
database_cross_reference: LCH:U004664
database_cross_reference: LCH_NW:sh85134957
database_cross_reference: LNC:LP18154-2
database_cross_reference: LNC:MTHU003501
database_cross_reference: MSH:D013910
database_cross_reference: MTHSPL:60YU5MIG9W
database_cross_reference: NDFRT:N0000166249
database_cross_reference: RCD:Xa1gh
database_cross_reference: RXNORM:1534769
database_cross_reference: SNMI:C-15700
database_cross_reference: SNOMEDCT_US:7269004

Uranium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
MCID: MC00013335
PMOID: PMO:00015287
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: U element
Synonym: URANIUM
Synonym: Uranium (substance)
Synonym: Uranium U-238
Synonym: Uranium [Chemical/Ingredient]
Synonym: Uranium, NOS
Synonym: Uranium, Natural
Synonym: uranium
Tree Number: T6.1.10.2.15
Tree Number: T6.1.10.6.52
Tree Number: T6.1.6.12.52
database_cross_reference: AOD:0000019548
database_cross_reference: CHV:0000012748
database_cross_reference: CSP:2540-8649
database_cross_reference: LCH:U004848
database_cross_reference: LCH_NW:sh85141276
database_cross_reference: LNC:LP16841-6
database_cross_reference: LNC:MTHU009462
database_cross_reference: MSH:D014501
database_cross_reference: MTH:U002336
database_cross_reference: MTHSPL:4OC371KSTK
database_cross_reference: NCI:C86020
database_cross_reference: NCI_FDA:4OC371KSTK
database_cross_reference: NDDF:006174
database_cross_reference: NDFRT:N0000166268
database_cross_reference: RXNORM:10999
database_cross_reference: SNMI:C-14000
database_cross_reference: SNOMEDCT_US:40584000

Polonium
type: Class
subclass of: Elements, Radioactive
subclass of: Chalcogens
subclass of: Metalloids
MCID: MC00010378
PMOID: PMO:00015288
Subclass_of: Chalcogens
Subclass_of: Elements, Radioactive
Subclass_of: Metalloids
Synonym: Polonium [Chemical/Ingredient]
Synonym: polonium
Tree Number: T6.1.6.11.2
Tree Number: T6.1.6.15.5
Tree Number: T6.1.6.2.6
database_cross_reference: AOD:0000019486
database_cross_reference: CHV:0000009900
database_cross_reference: LCH:U003749
database_cross_reference: LCH_NW:sh85104579
database_cross_reference: MSH:D011059
database_cross_reference: NDFRT:N0000166179

Promethium
type: Class
subclass of: Elements, Radioactive
MCID: MC00010691
PMOID: PMO:00015289
Subclass_of: Elements, Radioactive
Synonym: Promethium [Chemical/Ingredient]
Synonym: promethium
Tree Number: T6.1.6.2.7
database_cross_reference: AOD:0000019533
database_cross_reference: CHV:0000010180
database_cross_reference: LCH:U003855
database_cross_reference: LCH_NW:sh85107404
database_cross_reference: MSH:D011399
database_cross_reference: NDFRT:N0000166235

Radium
type: Class
subclass of: Elements, Radioactive
subclass of: Metals, Alkaline Earth
subclass of: Metals, Heavy
MCID: MC00011110
PMOID: PMO:00015290
Subclass_of: Elements, Radioactive
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Heavy
Synonym: Ra
Synonym: Radium (substance)
Synonym: Radium [Chemical/Ingredient]
Synonym: Radium, NOS
Synonym: radium
Tree Number: T6.1.10.4.3
Tree Number: T6.1.10.6.39
Tree Number: T6.1.6.12.39
Tree Number: T6.1.6.2.8
Tree Number: T6.1.6.7.5
database_cross_reference: AOD:0000019462
database_cross_reference: CHV:0000010556
database_cross_reference: LCH:U004036
database_cross_reference: LCH_NW:sh85110804
database_cross_reference: MSH:D011883
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2391
database_cross_reference: NDFRT:N0000166243
database_cross_reference: RXNORM:1546450
database_cross_reference: SNMI:C-13600
database_cross_reference: SNOMEDCT_US:73469000

Radon
type: Class
subclass of: Elements, Radioactive
subclass of: Noble Gases
MCID: MC00011113
PMOID: PMO:00015291
Subclass_of: Elements, Radioactive
Subclass_of: Noble Gases
Synonym: RADON
Synonym: Radon (substance)
Synonym: Radon [Chemical/Ingredient]
Synonym: Radon, NOS
Synonym: Rn
Synonym: Rn element
Synonym: radon
Tree Number: T6.1.6.2.9
Tree Number: T6.1.6.3.5
Tree Number: T6.1.8.6.5
database_cross_reference: AOD:0000013602
database_cross_reference: CHV:0000010559
database_cross_reference: CSP:2548-0292
database_cross_reference: LCH:U004038
database_cross_reference: LCH_NW:sh85110814
database_cross_reference: MEDLINEPLUS:1443
database_cross_reference: MSH:D011886
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C800
database_cross_reference: NCI_FDA:Q74S4N8N1G
database_cross_reference: NCI_NCI-GLOSS:CDR0000046554
database_cross_reference: NDFRT:N0000166180
database_cross_reference: SNM:E-5204
database_cross_reference: SNMI:C-13650
database_cross_reference: SNOMEDCT_US:72927002

Technetium
type: Class
subclass of: Elements, Radioactive
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00012575
PMOID: PMO:00015293
Subclass_of: Elements, Radioactive
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: TC
Synonym: TECHNETIUM
Synonym: Tc element
Synonym: Technetium (substance)
Synonym: Technetium [Chemical/Ingredient]
Synonym: Technetium, NOS
Synonym: technetium
Tree Number: T6.1.10.6.47
Tree Number: T6.1.6.12.47
Tree Number: T6.1.6.14.25
Tree Number: T6.1.6.2.10
database_cross_reference: AOD:0000019512
database_cross_reference: CHV:0000012058
database_cross_reference: CSP:2550-0895
database_cross_reference: LCH:U004594
database_cross_reference: LCH_NW:sh85133086
database_cross_reference: LNC:LP57566-9
database_cross_reference: MSH:D013667
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007138
database_cross_reference: NDFRT:N0000020228
database_cross_reference: SNMI:C-16300
database_cross_reference: SNOMEDCT_US:71789007
database_cross_reference: VANDF:4022222

Noble Gases
type: Class
subclass of: Elements
subclass of: Gases
MCID: MC00005444
PMOID: PMO:00015294
Subclass_of: Elements
Subclass_of: Gases
Synonym: 170-175 INERT GASES
Synonym: Elements, Group 18
Synonym: Gases, Inert
Synonym: Gases, Noble
Synonym: Gases, Rare
Synonym: Group 18 Elements
Synonym: INERT GASES
Synonym: Inert Gases
Synonym: Inert gas
Synonym: Inert gas (substance)
Tree Number: T6.1.6.3
Tree Number: T6.1.8.6
database_cross_reference: AOD:0000019495
database_cross_reference: CSP:1243-0936
database_cross_reference: LCH:U001919
database_cross_reference: LCH_NW:sh85053403
database_cross_reference: MSH:D005741
database_cross_reference: NDFRT:N0000007950
database_cross_reference: SNM:E-6680
database_cross_reference: SNM:U000150
database_cross_reference: SNMI:C-17000
database_cross_reference: SNOMEDCT_US:39769000

Argon
type: Class
subclass of: Noble Gases
MCID: MC00001231
PMOID: PMO:00015295
Subclass_of: Noble Gases
Synonym: 174 ARGON
Synonym: ARGON
Synonym: Ar element
Synonym: Argon (substance)
Synonym: Argon [Chemical/Ingredient]
Synonym: Argon, NOS
Synonym: argon
Tree Number: T6.1.6.3.1
Tree Number: T6.1.8.6.1
database_cross_reference: AOD:0000019498
database_cross_reference: CHV:0000001429
database_cross_reference: CSP:1243-1123
database_cross_reference: LCH:U000350
database_cross_reference: LCH_NW:sh85007108
database_cross_reference: LNC:LP101945-6
database_cross_reference: LNC:MTHU052448
database_cross_reference: MSH:D001128
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:67XQY1V3KH
database_cross_reference: NDFRT:N0000166175
database_cross_reference: RXNORM:1368133
database_cross_reference: SNMI:C-17400
database_cross_reference: SNOMEDCT_US:52503005

Helium
type: Class
subclass of: Noble Gases
MCID: MC00006005
PMOID: PMO:00015296
Subclass_of: Noble Gases
Synonym: 171 HELIUM
Synonym: Carbon Monox, Helium, Oxygen, Nitrogen L.D.M.
Synonym: Co-HE-O2-N2 Mixture
Synonym: Compressed Gas Oxidizing, N.O.S.
Synonym: Compressed Gas, N.O.S.
Synonym: Gaseous Inh Mixture 20% Oxygen 80% Helium
Synonym: HELIUM
Synonym: He
Synonym: He - Helium
Synonym: He element
Tree Number: T6.1.6.3.2
Tree Number: T6.1.8.6.2
database_cross_reference: AOD:0000019496
database_cross_reference: ATC:V03AN03
database_cross_reference: CHV:0000005922
database_cross_reference: CSP:1243-2996
database_cross_reference: DRUGBANK:DB09155
database_cross_reference: LCH:U002120
database_cross_reference: LCH_NW:sh85060043
database_cross_reference: LNC:LP101902-7
database_cross_reference: LNC:LP35985-8
database_cross_reference: LNC:MTHU052447
database_cross_reference: MMSL:d06862
database_cross_reference: MSH:D006371
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:206GF3GB41
database_cross_reference: NCI:C85242
database_cross_reference: NCI_FDA:206GF3GB41
database_cross_reference: NDDF:000716
database_cross_reference: NDFRT:N0000007123
database_cross_reference: NDFRT:N0000147379
database_cross_reference: PSY:22620
database_cross_reference: RCD:X799U
database_cross_reference: RXNORM:5140
database_cross_reference: SNMI:C-17100
database_cross_reference: SNOMEDCT_US:90317004
database_cross_reference: VANDF:4019128

Krypton
type: Class
subclass of: Noble Gases
MCID: MC00007286
PMOID: PMO:00015297
Subclass_of: Noble Gases
Synonym: 173 KRYPTON
Synonym: KRYPTON
Synonym: Krypton (substance)
Synonym: Krypton [Chemical/Ingredient]
Synonym: Krypton, NOS
Synonym: krypton
Tree Number: T6.1.6.3.3
Tree Number: T6.1.8.6.3
database_cross_reference: AOD:0000019499
database_cross_reference: CSP:1243-0936
database_cross_reference: LCH:U002592
database_cross_reference: LCH_NW:sh85073327
database_cross_reference: MSH:D007726
database_cross_reference: NDFRT:N0000166173
database_cross_reference: SNMI:C-17300
database_cross_reference: SNOMEDCT_US:12375004

Neon
type: Class
subclass of: Noble Gases
MCID: MC00008710
PMOID: PMO:00015298
Subclass_of: Noble Gases
Synonym: 175 NEON
Synonym: Co-NE-O2-N2 Mixture
Synonym: Lung Diffusion Test Mix No Ne Co
Synonym: NEON
Synonym: Ne element
Synonym: Neon (substance)
Synonym: Neon [Chemical/Ingredient]
Synonym: Neon, NOS
Synonym: neon
Tree Number: T6.1.6.3.4
Tree Number: T6.1.8.6.4
database_cross_reference: AOD:0000019497
database_cross_reference: CHV:0000008556
database_cross_reference: CSP:1243-6742
database_cross_reference: DRUGBANK:DB11589
database_cross_reference: LCH:U003150
database_cross_reference: LCH_NW:sh85090790
database_cross_reference: MSH:D009356
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:000717
database_cross_reference: NDFRT:N0000166174
database_cross_reference: RXNORM:7301
database_cross_reference: SNMI:C-17500
database_cross_reference: SNOMEDCT_US:12112000

Xenon
type: Class
subclass of: Noble Gases
MCID: MC00013759
PMOID: PMO:00015299
Subclass_of: Noble Gases
Synonym: 172 XENON
Synonym: XENON
Synonym: Xe
Synonym: Xe - Xenon
Synonym: Xe element
Synonym: Xenon (substance)
Synonym: Xenon [Chemical/Ingredient]
Synonym: Xenon, NOS
Synonym: xenon
Synonym: xenon xe
Tree Number: T6.1.6.3.6
Tree Number: T6.1.8.6.6
database_cross_reference: AOD:0000007200
database_cross_reference: ATC:N01AX15
database_cross_reference: CHV:0000013231
database_cross_reference: CSP:1243-8625
database_cross_reference: DRUGBANK:DB09315
database_cross_reference: LCH:U005059
database_cross_reference: LCH_NW:sh85148790
database_cross_reference: LNC:LP188442-0
database_cross_reference: LNC:LP34323-3
database_cross_reference: LNC:MTHU052554
database_cross_reference: MMSL:192699
database_cross_reference: MSH:D014978
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85247
database_cross_reference: NCI_FDA:3H3U766W84
database_cross_reference: NDDF:000718
database_cross_reference: NDFRT:N0000007405
database_cross_reference: NDFRT:N0000147400
database_cross_reference: RCD:X90Er
database_cross_reference: RXNORM:11363
database_cross_reference: SNMI:C-17200
database_cross_reference: SNOMEDCT_US:83598005
database_cross_reference: VANDF:4019155

Xenon Isotopes
type: Class
subclass of: Isotopes
MCID: MC00013760
PMOID: PMO:00015300
Subclass_of: Isotopes
Synonym: Isotopes, Xenon
Synonym: Xenon Isotopes [Chemical/Ingredient]
Synonym: Xenon isotope
Synonym: Xenon isotope (substance)
Synonym: Xenon--Isotopes
Tree Number: T6.1.9.21
database_cross_reference: LCH_NW:sh85148791
database_cross_reference: MSH:D014979
database_cross_reference: NDFRT:N0000166129
database_cross_reference: SNMI:C-17201
database_cross_reference: SNOMEDCT_US:16745008

Xenon Radioisotopes
type: Class
subclass of: Xenon Isotopes
subclass of: Radioisotopes
MCID: MC00013761
PMOID: PMO:00015301
Subclass_of: Radioisotopes
Subclass_of: Xenon Isotopes
Synonym: Radioisotopes, Xenon
Synonym: Xenon Radioisotopes [Chemical/Ingredient]
Synonym: Xenon radioisotope
Synonym: Xenon radioisotope (substance)
Synonym: Xenon radioisotope, NOS
Tree Number: T6.1.9.17.36
Tree Number: T6.1.9.21.1
database_cross_reference: MSH:D014980
database_cross_reference: NDFRT:N0000166130
database_cross_reference: SNMI:C-172A0
database_cross_reference: SNOMEDCT_US:44776005

Halogens
type: Class
subclass of: Elements
MCID: MC00005930
PMOID: PMO:00015302
Subclass_of: Elements
Synonym: Elements, Group 17
Synonym: Group 17 Elements
Synonym: Halogen
Synonym: Halogen (substance)
Synonym: Halogen, NOS
Synonym: Halogens [Chemical/Ingredient]
Synonym: halogen
Synonym: halogen elements
Synonym: halogens
Tree Number: T6.1.6.4
database_cross_reference: AOD:0000019488
database_cross_reference: CHV:0000005781
database_cross_reference: CSP:4000-0196
database_cross_reference: LCH:U002072
database_cross_reference: MSH:D006219
database_cross_reference: NDFRT:N0000007573
database_cross_reference: SNMI:C-11000
database_cross_reference: SNOMEDCT_US:28227002

Bromine
type: Class
subclass of: Halogens
MCID: MC00001955
PMOID: PMO:00015303
Subclass_of: Halogens
Synonym: BROMINE
Synonym: Br - Bromine
Synonym: Br element
Synonym: Br- element
Synonym: Bromine (substance)
Synonym: Bromine [Chemical/Ingredient]
Synonym: Bromine, NOS
Synonym: bromine
Tree Number: T6.1.6.4.2
database_cross_reference: AOD:0000019491
database_cross_reference: CHV:0000002173
database_cross_reference: CSP:1374-2377
database_cross_reference: LCH:U000685
database_cross_reference: LCH_NW:sh85017053
database_cross_reference: LNC:MTHU017569
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D001966
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:SBV4XY874G
database_cross_reference: NDFRT:N0000166170
database_cross_reference: RCD:Xa4kF
database_cross_reference: RXNORM:1311476
database_cross_reference: SNM:F-10100
database_cross_reference: SNMI:C-11300
database_cross_reference: SNOMEDCT_US:85378003

Chlorine
type: Class
subclass of: Halogens
subclass of: Gases
MCID: MC00002650
PMOID: PMO:00015304
Subclass_of: Gases
Subclass_of: Halogens
Synonym: CHLORINE
Synonym: Chlorine (substance)
Synonym: Chlorine [Chemical/Ingredient]
Synonym: Chlorine gas
Synonym: Chlorine, NOS
Synonym: Cl
Synonym: Cl - Chlorine
Synonym: Cl element
Synonym: chlorine
Synonym: chlorine gas
Tree Number: T6.1.6.4.3
Tree Number: T6.1.8.5
database_cross_reference: AOD:0000019490
database_cross_reference: AOD:0000028717
database_cross_reference: CHV:0000002824
database_cross_reference: CSP:1374-2714
database_cross_reference: CSP:4007-0028
database_cross_reference: DRUGBANK:DB11109
database_cross_reference: LCH:U000972
database_cross_reference: LCH_NW:sh85024541
database_cross_reference: LNC:LP18922-2
database_cross_reference: LNC:MTHU006887
database_cross_reference: MSH:D002713
database_cross_reference: MTH:U001805
database_cross_reference: MTHSPL:4R7X1O2820
database_cross_reference: NCI:C28140
database_cross_reference: NCI_NCI-GLOSS:CDR0000044424
database_cross_reference: NDFRT:N0000166171
database_cross_reference: NDFRT:N0000171756
database_cross_reference: RCD:X79Au
database_cross_reference: RXNORM:1310122
database_cross_reference: SNMI:C-11200
database_cross_reference: SNOMEDCT_US:29276003
database_cross_reference: VANDF:4025220

Fluorine
type: Class
subclass of: Halogens
MCID: MC00005194
PMOID: PMO:00015305
Subclass_of: Halogens
Synonym: F
Synonym: F - Fluorine
Synonym: F element
Synonym: FLUORINE
Synonym: Fluorine (substance)
Synonym: Fluorine [Chemical/Ingredient]
Synonym: Fluorine, NOS
Synonym: fluorine
Synonym: fluorines
Tree Number: T6.1.6.4.4
database_cross_reference: AOD:0000019489
database_cross_reference: CHV:0000005122
database_cross_reference: CSP:1374-2951
database_cross_reference: CSP:4007-0046
database_cross_reference: LCH:U001829
database_cross_reference: LCH_NW:sh85049424
database_cross_reference: MSH:D005461
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:284SYP0193
database_cross_reference: NCI:C502
database_cross_reference: NDFRT:N0000010504
database_cross_reference: NDFRT:N0000023134
database_cross_reference: RCD:Ub09Y
database_cross_reference: RXNORM:1310123
database_cross_reference: SNMI:C-11100
database_cross_reference: SNOMEDCT_US:35883004
database_cross_reference: VANDF:4017805

Iodine
type: Class
subclass of: Halogens
MCID: MC00006993
PMOID: PMO:00015306
Subclass_of: Halogens
Synonym: Alphadine Scrub Foam Antimicrobial Foam
Synonym: Alphadine Scrub Topical Microbiocidal Skin Cleanser
Synonym: Basic Foley Cath Kit Iodophor Pvp Pad 1%
Synonym: Blood Culture Prep Kit
Synonym: CVS Iodine
Synonym: Chela Potassium Plus
Synonym: Colloidal Iodine Ophthalmic
Synonym: Diodine
Synonym: Foam Care Pvp Iodophor Surg Hand Scrub 0.75%
Synonym: GNP Idoinde Tincture 2% Mild
Tree Number: T6.1.6.4.5
database_cross_reference: AOD:0000007536
database_cross_reference: ATC:D08AG03
database_cross_reference: CHV:0000006899
database_cross_reference: CSP:1374-3188
database_cross_reference: DRUGBANK:DB00898
database_cross_reference: DRUGBANK:DB05382
database_cross_reference: DRUGBANK:DB06715
database_cross_reference: DRUGBANK:DB06812
database_cross_reference: DRUGBANK:DB11119
database_cross_reference: LCH:U002497
database_cross_reference: LCH_NW:sh85067769
database_cross_reference: LNC:LP15157-8
database_cross_reference: LNC:MTHU009375
database_cross_reference: MEDCIN:198714
database_cross_reference: MEDCIN:199206
database_cross_reference: MMSL:4900
database_cross_reference: MMSL:d05776
database_cross_reference: MSH:D007455
database_cross_reference: MTH:U002017
database_cross_reference: MTHSPL:9679TC07X4
database_cross_reference: NCI:C594
database_cross_reference: NCI_DCP:04675
database_cross_reference: NCI_DTP:NSC0042355
database_cross_reference: NCI_FDA:9679TC07X4
database_cross_reference: NCI_NCI-GLOSS:CDR0000044548
database_cross_reference: NDDF:000852
database_cross_reference: NDDF:003150
database_cross_reference: NDDF:007599
database_cross_reference: NDFRT:N0000007196
database_cross_reference: NDFRT:N0000146037
database_cross_reference: RCD:XM0lG
database_cross_reference: RCD:fa2..
database_cross_reference: RXNORM:5933
database_cross_reference: SNM:F-10310
database_cross_reference: SNMI:C-11400
database_cross_reference: SNOMEDCT_US:325330005
database_cross_reference: SNOMEDCT_US:44588005
database_cross_reference: VANDF:4017659

Iodine Isotopes
type: Class
subclass of: Isotopes
MCID: MC00006994
PMOID: PMO:00015307
Subclass_of: Isotopes
Synonym: Iodine Isotopes [Chemical/Ingredient]
Synonym: Iodine isotope
Synonym: Iodine isotope (substance)
Synonym: Iodine--Isotopes
Synonym: Isotopes, Iodine
Tree Number: T6.1.9.10
database_cross_reference: LCH_NW:sh85067771
database_cross_reference: MSH:D007456
database_cross_reference: NDFRT:N0000166139
database_cross_reference: SNMI:C-11401
database_cross_reference: SNOMEDCT_US:67719005

Iodine Radioisotopes
type: Class
subclass of: Iodine Isotopes
subclass of: Radioisotopes
MCID: MC00006995
PMOID: PMO:00015308
Subclass_of: Iodine Isotopes
Subclass_of: Radioisotopes
Synonym: Iodine Radioisotopes [Chemical/Ingredient]
Synonym: Iodine radioesotope, NOS
Synonym: Iodine radioisotope
Synonym: Iodine radioisotope (substance)
Synonym: Iodine radioisotope, NOS
Synonym: Radioisotopes, Iodine
Tree Number: T6.1.9.10.1
Tree Number: T6.1.9.17.16
database_cross_reference: MSH:D007457
database_cross_reference: NDFRT:N0000166140
database_cross_reference: SNM:E-510X
database_cross_reference: SNMI:C-114A0
database_cross_reference: SNOMEDCT_US:14399003

Hydrogen
type: Class
subclass of: Elements
subclass of: Gases
MCID: MC00006468
PMOID: PMO:00015309
Subclass_of: Elements
Subclass_of: Gases
Synonym: H - Hydrogen
Synonym: H element
Synonym: H2 - Hydrogen
Synonym: HYDROGEN
Synonym: Hydrogen (substance)
Synonym: Hydrogen [Chemical/Ingredient]
Synonym: Hydrogen, NOS
Synonym: hydrogen
Synonym: hydrogen (H)
Tree Number: T6.1.6.5
Tree Number: T6.1.8.7
database_cross_reference: AOD:0000001304
database_cross_reference: CHV:0000006354
database_cross_reference: CSP:1473-8637
database_cross_reference: CSP:4007-0059
database_cross_reference: LCH:U002277
database_cross_reference: LCH_NW:sh85063416
database_cross_reference: LNC:LP15643-7
database_cross_reference: MSH:D006859
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7YNJ3PO35Z
database_cross_reference: NDFRT:N0000166166
database_cross_reference: PSY:23650
database_cross_reference: RCD:X80At
database_cross_reference: RXNORM:5497
database_cross_reference: SNM:E-5011
database_cross_reference: SNMI:C-10100
database_cross_reference: SNOMEDCT_US:2141009

Deuterium
type: Class
subclass of: Hydrogen
subclass of: Isotopes
MCID: MC00003756
PMOID: PMO:00015310
Subclass_of: Hydrogen
Subclass_of: Isotopes
Synonym: 2 H
Synonym: 2H
Synonym: Deuterium (substance)
Synonym: Deuterium [Chemical/Ingredient]
Synonym: Deuterium gas
Synonym: H2 isotope
Synonym: Heavy hydrogen
Synonym: ^2^H
Synonym: deuterium
Synonym: h 2
Tree Number: T6.1.6.5.1
Tree Number: T6.1.8.7.1
Tree Number: T6.1.9.7
database_cross_reference: AOD:0000019449
database_cross_reference: CHV:0000003818
database_cross_reference: CSP:1647-6878
database_cross_reference: LCH:U001361
database_cross_reference: LCH_NW:sh85037316
database_cross_reference: MSH:D003903
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166156
database_cross_reference: SNM:E-5014
database_cross_reference: SNMI:C-10102
database_cross_reference: SNOMEDCT_US:91137000

Tritium
type: Class
subclass of: Hydrogen
subclass of: Radioisotopes
MCID: MC00013139
PMOID: PMO:00015311
Subclass_of: Hydrogen
Subclass_of: Radioisotopes
Synonym: 3 H
Synonym: 3 h
Synonym: 3H
Synonym: H3 radionuclide
Synonym: Hydrogen 3
Synonym: Hydrogen-3
Synonym: Tritium (substance)
Synonym: Tritium [Chemical/Ingredient]
Synonym: ^3^H
Synonym: h 3
Tree Number: T6.1.6.5.3
Tree Number: T6.1.8.7.3
Tree Number: T6.1.9.17.35
database_cross_reference: AOD:0000019450
database_cross_reference: CHV:0000012588
database_cross_reference: CSP:2543-6275
database_cross_reference: LCH:U004789
database_cross_reference: LCH_NW:sh85137936
database_cross_reference: LNC:LP29127-5
database_cross_reference: LNC:MTHU013330
database_cross_reference: MSH:D014316
database_cross_reference: NDFRT:N0000166155
database_cross_reference: SNM:E-5012
database_cross_reference: SNMI:C-10103
database_cross_reference: SNOMEDCT_US:16082008

Metals, Alkali
type: Class
subclass of: Elements
subclass of: Metals
MCID: MC00008136
PMOID: PMO:00015312
Subclass_of: Elements
Subclass_of: Metals
Synonym: Alkali Metals
Synonym: Alkali metals
Synonym: Elements, Group 1
Synonym: Group 1 Elements
Synonym: Metals, Alkali [Chemical/Ingredient]
Synonym: alkali metal
Synonym: alkali metals
Tree Number: T6.1.10.3
Tree Number: T6.1.6.6
database_cross_reference: AOD:0000019453
database_cross_reference: CSP:1852-5946
database_cross_reference: LCH_NW:sh85003587
database_cross_reference: MSH:D008672
database_cross_reference: NDFRT:N0000007991

Cesium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Heavy
MCID: MC00002561
PMOID: PMO:00015313
Subclass_of: Metals, Alkali
Subclass_of: Metals, Heavy
Synonym: CESIUM
Synonym: Caesium
Synonym: Cesium (substance)
Synonym: Cesium [Chemical/Ingredient]
Synonym: Cesium, NOS
Synonym: Cs element
Synonym: caesium
Synonym: cesium
Synonym: cesium (Cs)
Tree Number: T6.1.10.3.1
Tree Number: T6.1.10.6.9
Tree Number: T6.1.6.12.9
Tree Number: T6.1.6.6.1
database_cross_reference: AOD:0000019456
database_cross_reference: CHV:0000002704
database_cross_reference: CSP:1852-6049
database_cross_reference: LCH:U000918
database_cross_reference: LCH_NW:sh85022200
database_cross_reference: LNC:LP16811-9
database_cross_reference: LNC:MTHU014149
database_cross_reference: MSH:D002586
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:1KSV9V4Y4I
database_cross_reference: NDDF:014059
database_cross_reference: NDFRT:N0000166264
database_cross_reference: RXNORM:1310121
database_cross_reference: SNM:F-10220
database_cross_reference: SNMI:C-14200
database_cross_reference: SNOMEDCT_US:5040002

Cesium Isotopes
type: Class
subclass of: Isotopes
MCID: MC00002562
PMOID: PMO:00015314
Subclass_of: Isotopes
Synonym: Caesium isotope
Synonym: Cesium Isotopes [Chemical/Ingredient]
Synonym: Cesium isotope
Synonym: Cesium isotope (substance)
Synonym: Cesium isotope [dup] (substance)
Synonym: Cesium--Isotopes
Synonym: Isotopes, Cesium
Tree Number: T6.1.9.4
database_cross_reference: LCH_NW:sh85022201
database_cross_reference: MSH:D002587
database_cross_reference: NDFRT:N0000166121
database_cross_reference: SNMI:C-14201
database_cross_reference: SNOMEDCT_US:276174007
database_cross_reference: SNOMEDCT_US:53532001

Cesium Radioisotopes
type: Class
subclass of: Cesium Isotopes
subclass of: Radioisotopes
MCID: MC00002563
PMOID: PMO:00015315
Subclass_of: Cesium Isotopes
Subclass_of: Radioisotopes
Synonym: Caesium radioisotope
Synonym: Cesium Radioisotopes [Chemical/Ingredient]
Synonym: Cesium radioisotope
Synonym: Cesium radioisotope (substance)
Synonym: Cesium radioisotope [dup] (substance)
Synonym: Cesium radioisotope, NOS
Synonym: Radioisotopes, Cesium
Tree Number: T6.1.9.17.7
Tree Number: T6.1.9.4.1
database_cross_reference: MSH:D002588
database_cross_reference: NDFRT:N0000166122
database_cross_reference: SNM:E-5220
database_cross_reference: SNMI:C-142A0
database_cross_reference: SNOMEDCT_US:276175008
database_cross_reference: SNOMEDCT_US:69703007

Lithium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Light
MCID: MC00007637
PMOID: PMO:00015316
Subclass_of: Metals, Alkali
Subclass_of: Metals, Light
Synonym: LITHIUM
Synonym: Li
Synonym: Li - Lithium
Synonym: Li element
Synonym: Li+ element
Synonym: Lithium (product)
Synonym: Lithium (substance)
Synonym: Lithium Metallicum
Synonym: Lithium [Chemical/Ingredient]
Synonym: Lithium product
Tree Number: T6.1.10.3.3
Tree Number: T6.1.10.7.3
Tree Number: T6.1.6.13.3
Tree Number: T6.1.6.6.3
database_cross_reference: AOD:0000019454
database_cross_reference: ATC:N05AN01
database_cross_reference: CHV:0000007490
database_cross_reference: CSP:1852-6098
database_cross_reference: DRUGBANK:DB01356
database_cross_reference: LCH:U002722
database_cross_reference: LCH_NW:sh85077577
database_cross_reference: LNC:LP16175-9
database_cross_reference: LNC:MTHU004197
database_cross_reference: MEDCIN:199593
database_cross_reference: MMSL:d00061
database_cross_reference: MSH:D008094
database_cross_reference: MTH:U002050
database_cross_reference: MTHSPL:9FN79X2M3F
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C1318
database_cross_reference: NCI:C95186
database_cross_reference: NCI_FDA:9FN79X2M3F
database_cross_reference: NCI_NCI-GLOSS:CDR0000476347
database_cross_reference: NDDF:001532
database_cross_reference: NDFRT:N0000147892
database_cross_reference: NDFRT:N0000166224
database_cross_reference: PDQ:CDR0000039491
database_cross_reference: PSY:28590
database_cross_reference: RCD:XM0lB
database_cross_reference: RCD:d6...
database_cross_reference: RXNORM:6448
database_cross_reference: SNM:F-10380
database_cross_reference: SNMI:C-15400
database_cross_reference: SNOMEDCT_US:321719003
database_cross_reference: SNOMEDCT_US:85899009
database_cross_reference: USPMG:MTHU000811
database_cross_reference: VANDF:4019803

Potassium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Light
MCID: MC00010519
PMOID: PMO:00015317
Subclass_of: Metals, Alkali
Subclass_of: Metals, Light
Synonym: Alphaligo
Synonym: Aminosyn 3.5% M
Synonym: Aqua-S Supplement
Synonym: B 6 Plus
Synonym: Bseltzer
Synonym: Buffered Vitamin C Powder With Ca Mg and K
Synonym: Buffered Vitamin C Pwr W Cal-mag-potassium
Synonym: C-1000 Plus Zinc & Potassium
Synonym: C.R.D.-force
Synonym: Cal & Mag Hvp Chel Plus C Potass & Zinc Tab
Tree Number: T6.1.10.3.4
Tree Number: T6.1.10.7.5
Tree Number: T6.1.6.13.5
Tree Number: T6.1.6.6.4
database_cross_reference: AOD:0000002435
database_cross_reference: CCPSS:1006930
database_cross_reference: CCPSS:1013246
database_cross_reference: CHV:0000010004
database_cross_reference: CSP:2390-5099
database_cross_reference: CSP:4007-0102
database_cross_reference: DRUGBANK:DB01345
database_cross_reference: LCH:U003782
database_cross_reference: LCH_NW:sh85105593
database_cross_reference: LNC:LP15098-4
database_cross_reference: LNC:LP32134-6
database_cross_reference: LNC:MTHU003561
database_cross_reference: MEDCIN:41250
database_cross_reference: MMSL:5321
database_cross_reference: MSH:D011188
database_cross_reference: MTH:U000145
database_cross_reference: MTH:U000315
database_cross_reference: MTH:U002180
database_cross_reference: MTHSPL:RWP5GA015D
database_cross_reference: NCI:C765
database_cross_reference: NCI_DCP:31091
database_cross_reference: NCI_NCI-GLOSS:CDR0000044344
database_cross_reference: NDDF:000763
database_cross_reference: NDFRT:N0000005839
database_cross_reference: NDFRT:N0000146069
database_cross_reference: PSY:39750
database_cross_reference: RCD:X80D4
database_cross_reference: RCD:x01Pg
database_cross_reference: RXNORM:8588
database_cross_reference: SNM:F-10530
database_cross_reference: SNMI:C-13500
database_cross_reference: SNOMEDCT_US:350560002
database_cross_reference: SNOMEDCT_US:88480006
database_cross_reference: USPMG:MTHU001685
database_cross_reference: VANDF:4017695

Potassium Isotopes
type: Class
subclass of: Isotopes
MCID: MC00010529
PMOID: PMO:00015318
Subclass_of: Isotopes
Synonym: Isotopes, Potassium
Synonym: Potassium Isotopes [Chemical/Ingredient]
Synonym: Potassium isotope
Synonym: Potassium isotope (substance)
Synonym: Potassium--Isotopes
Tree Number: T6.1.9.16
database_cross_reference: LCH_NW:sh85105594
database_cross_reference: MSH:D011194
database_cross_reference: NDFRT:N0000166147
database_cross_reference: SNMI:C-13501
database_cross_reference: SNOMEDCT_US:14146003

Potassium Radioisotopes
type: Class
subclass of: Potassium Isotopes
subclass of: Radioisotopes
MCID: MC00010535
PMOID: PMO:00015319
Subclass_of: Potassium Isotopes
Subclass_of: Radioisotopes
Synonym: Potassium Radioisotopes [Chemical/Ingredient]
Synonym: Potassium radioisotope
Synonym: Potassium radioisotope (substance)
Synonym: Potassium radioisotope, NOS
Synonym: Radioisotopes, Potassium
Tree Number: T6.1.9.16.1
Tree Number: T6.1.9.17.25
database_cross_reference: MSH:D011197
database_cross_reference: NDFRT:N0000166148
database_cross_reference: SNM:E-5193
database_cross_reference: SNMI:C-135A0
database_cross_reference: SNOMEDCT_US:56167000

Rubidium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Heavy
MCID: MC00011517
PMOID: PMO:00015320
Subclass_of: Metals, Alkali
Subclass_of: Metals, Heavy
Synonym: RUBIDIUM
Synonym: Rb
Synonym: Rb element
Synonym: Rubidium (substance)
Synonym: Rubidium Metallicum
Synonym: Rubidium [Chemical/Ingredient]
Synonym: Rubidium, NOS
Synonym: rubidium
Synonym: rubidium (Rb)
Tree Number: T6.1.10.3.5
Tree Number: T6.1.10.6.42
Tree Number: T6.1.6.12.42
Tree Number: T6.1.6.6.5
database_cross_reference: AOD:0000019455
database_cross_reference: CHV:0000010963
database_cross_reference: CSP:1852-6152
database_cross_reference: LCH:U004171
database_cross_reference: LCH_NW:sh85115684
database_cross_reference: LNC:LP16833-3
database_cross_reference: LNC:MTHU014145
database_cross_reference: MSH:D012413
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:MLT4718TJW
database_cross_reference: NCI:C95191
database_cross_reference: NCI_FDA:MLT4718TJW
database_cross_reference: NDFRT:N0000005885
database_cross_reference: RXNORM:1311489
database_cross_reference: SNM:F-10540
database_cross_reference: SNMI:C-15900
database_cross_reference: SNOMEDCT_US:51304003

Sodium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Light
MCID: MC00011962
PMOID: PMO:00015321
Subclass_of: Metals, Alkali
Subclass_of: Metals, Light
Synonym: Na
Synonym: Na - Sodium
Synonym: Na element
Synonym: SODIUM
Synonym: Sodium (NOS)
Synonym: Sodium (substance)
Synonym: Sodium [Chemical/Ingredient]
Synonym: Sodium, NOS
Synonym: na sodium
Synonym: sodium
Tree Number: T6.1.10.3.6
Tree Number: T6.1.10.7.6
Tree Number: T6.1.6.13.6
Tree Number: T6.1.6.6.6
database_cross_reference: AOD:0000005817
database_cross_reference: AOD:0000028710
database_cross_reference: CCPSS:0024754
database_cross_reference: CHV:0000011478
database_cross_reference: CSP:2730-2702
database_cross_reference: CSP:4007-0114
database_cross_reference: LCH:U004374
database_cross_reference: LCH_NW:sh85124249
database_cross_reference: LNC:LP15099-2
database_cross_reference: LNC:LP32156-9
database_cross_reference: LNC:MTHU003686
database_cross_reference: MEDLINEPLUS:3666
database_cross_reference: MMSL:5467
database_cross_reference: MSH:D012964
database_cross_reference: MTH:U003358
database_cross_reference: MTHSPL:9NEZ333N27
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C830
database_cross_reference: NCI_DCP:31090
database_cross_reference: NCI_NCI-GLOSS:CDR0000044731
database_cross_reference: NDDF:000755
database_cross_reference: NDFRT:N0000007201
database_cross_reference: NDFRT:N0000146496
database_cross_reference: PSY:48590
database_cross_reference: RCD:X80D5
database_cross_reference: RXNORM:9853
database_cross_reference: SNM:F-10580
database_cross_reference: SNMI:C-15500
database_cross_reference: SNOMEDCT_US:39972003
database_cross_reference: USPMG:MTHU001768
database_cross_reference: VANDF:4018159

Sodium Isotopes
type: Class
subclass of: Isotopes
MCID: MC00011998
PMOID: PMO:00015322
Subclass_of: Isotopes
Synonym: Isotopes, Sodium
Synonym: Sodium Isotopes [Chemical/Ingredient]
Synonym: Sodium isotope
Synonym: Sodium isotope (substance)
Tree Number: T6.1.9.18
database_cross_reference: MSH:D012975
database_cross_reference: NDFRT:N0000166131
database_cross_reference: SNMI:C-15501
database_cross_reference: SNOMEDCT_US:31936008

Sodium Radioisotopes
type: Class
subclass of: Sodium Isotopes
subclass of: Radioisotopes
MCID: MC00012014
PMOID: PMO:00015323
Subclass_of: Radioisotopes
Subclass_of: Sodium Isotopes
Synonym: Radioisotopes, Sodium
Synonym: Sodium Radioisotopes [Chemical/Ingredient]
Synonym: Sodium radioisotope
Synonym: Sodium radioisotope (substance)
Synonym: Sodium radioisotope, NOS
Tree Number: T6.1.9.17.30
Tree Number: T6.1.9.18.1
database_cross_reference: MSH:D012979
database_cross_reference: NDFRT:N0000166132
database_cross_reference: SNM:E-5244
database_cross_reference: SNMI:C-155A0
database_cross_reference: SNOMEDCT_US:76527008

Metals, Alkaline Earth
type: Class
subclass of: Elements
subclass of: Metals
MCID: MC00008137
PMOID: PMO:00015324
Subclass_of: Elements
Subclass_of: Metals
Synonym: Alkaline Earth Metals
Synonym: Alkaline earth metals
Synonym: Earth Metals, Alkaline
Synonym: Elements, Group 2
Synonym: Group 2 Elements
Synonym: Metals, Alkaline Earth [Chemical/Ingredient]
Synonym: alkaline earth metal
Synonym: alkaline earth metals
Tree Number: T6.1.10.4
Tree Number: T6.1.6.7
database_cross_reference: AOD:0000019458
database_cross_reference: CSP:1852-6255
database_cross_reference: LCH:U000145
database_cross_reference: LCH_NW:sh85003595
database_cross_reference: MSH:D008673
database_cross_reference: NDFRT:N0000007992

Barium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: Metals, Heavy
MCID: MC00001495
PMOID: PMO:00015325
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Heavy
Synonym: BARIUM
Synonym: Ba
Synonym: Ba - Barium
Synonym: Ba element
Synonym: Barium (product)
Synonym: Barium (substance)
Synonym: Barium [Chemical/Ingredient]
Synonym: Barium, NOS
Synonym: ba
Synonym: barium
Tree Number: T6.1.10.4.1
Tree Number: T6.1.10.6.4
Tree Number: T6.1.6.12.4
Tree Number: T6.1.6.7.1
database_cross_reference: AOD:0000019461
database_cross_reference: CHV:0000001701
database_cross_reference: CSP:1852-6358
database_cross_reference: DRUGBANK:DB12481
database_cross_reference: LCH:U000499
database_cross_reference: LCH_NW:sh85011853
database_cross_reference: LNC:LP16803-6
database_cross_reference: LNC:MTHU006093
database_cross_reference: MSH:D001464
database_cross_reference: MTH:U001727
database_cross_reference: MTHSPL:24GP945V5T
database_cross_reference: NCI:C61475
database_cross_reference: NCI_FDA:24GP945V5T
database_cross_reference: NDFRT:N0000166273
database_cross_reference: PSY:05420
database_cross_reference: RCD:X808b
database_cross_reference: RXNORM:1311067
database_cross_reference: SNM:F-10080
database_cross_reference: SNMI:C-12200
database_cross_reference: SNOMEDCT_US:39290007
database_cross_reference: SNOMEDCT_US:426728000
database_cross_reference: UMD:-1929

Beryllium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: Metals, Light
MCID: MC00001628
PMOID: PMO:00015326
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Light
Synonym: BERYLLIUM
Synonym: Be
Synonym: Be - Beryllium
Synonym: Be element
Synonym: Beryllium (substance)
Synonym: Beryllium Metal
Synonym: Beryllium Powder
Synonym: Beryllium [Chemical/Ingredient]
Synonym: Beryllium, NOS
Synonym: beryllium
Tree Number: T6.1.10.7.2
Tree Number: T6.1.6.13.2
Tree Number: T6.1.6.7.2
database_cross_reference: AOD:0000019459
database_cross_reference: CHV:0000001816
database_cross_reference: CSP:1852-6461
database_cross_reference: LCH:U000545
database_cross_reference: LCH_NW:sh85013403
database_cross_reference: LNC:LP16805-1
database_cross_reference: LNC:MTHU005565
database_cross_reference: MSH:D001608
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:OW5102UV6N
database_cross_reference: NCI:C44338
database_cross_reference: NCI_FDA:OW5102UV6N
database_cross_reference: NDFRT:N0000166277
database_cross_reference: RCD:X794s
database_cross_reference: RXNORM:1310252
database_cross_reference: SNMI:C-12300
database_cross_reference: SNOMEDCT_US:88014003

Calcium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: PMO:00021947
MCID: MC00002107
PMOID: PMO:00015327
Subclass_of: Blood Coagulation Factors
Subclass_of: Metals, Alkaline Earth
Synonym: 7030 Calcium Gold
Synonym: 7030 Calcium Premium
Synonym: A D Calcium Tab
Synonym: A-D Calcium Cap
Synonym: A.R.T.H. Away Formula
Synonym: Act Etidrocal
Synonym: Acti-cal/mag 2:1 + Zinc and D Caplet
Synonym: Acti-megascorb Crystals Pwr
Synonym: Actical Plus Calcium-magnesium-vitamin D3-silicon Chewable
Synonym: Active Calcium Plus Magnesium, Vitamin D and Silicon
Tree Number: T6.1.10.4.2
Tree Number: T6.1.6.7.3
Tree Number: T6.13.4.2
database_cross_reference: AOD:0000001937
database_cross_reference: AOD:0000028712
database_cross_reference: CHV:0000002292
database_cross_reference: CSP:0530-2463
database_cross_reference: CSP:4007-0018
database_cross_reference: DRUGBANK:DB01373
database_cross_reference: LCH:U000740
database_cross_reference: LCH_NW:sh85018768
database_cross_reference: LNC:LP15257-6
database_cross_reference: LNC:LP32547-9
database_cross_reference: LNC:LP70404-6
database_cross_reference: LNC:MTHU001930
database_cross_reference: MEDCIN:41226
database_cross_reference: MMSL:4325
database_cross_reference: MMSL:6778
database_cross_reference: MSH:D002118
database_cross_reference: MTH:U000229
database_cross_reference: MTH:U001774
database_cross_reference: MTHSPL:SY7Q814VUP
database_cross_reference: NCI:C331
database_cross_reference: NCI_DCP:30724
database_cross_reference: NCI_FDA:SY7Q814VUP
database_cross_reference: NCI_NCI-GLOSS:CDR0000045632
database_cross_reference: NDDF:000771
database_cross_reference: NDFRT:N0000006512
database_cross_reference: NDFRT:N0000146031
database_cross_reference: PSY:07240
database_cross_reference: RCD:X80Cy
database_cross_reference: RCD:Xa4k9
database_cross_reference: RXNORM:1895
database_cross_reference: SNM:F-10120
database_cross_reference: SNM:F-53040
database_cross_reference: SNMI:C-14300
database_cross_reference: SNMI:F-D7340
database_cross_reference: SNOMEDCT_US:290128009
database_cross_reference: SNOMEDCT_US:5540006
database_cross_reference: SNOMEDCT_US:80161001
database_cross_reference: VANDF:4017652

Calcium Isotopes
type: Class
subclass of: Isotopes
MCID: MC00002123
PMOID: PMO:00015328
Subclass_of: Isotopes
Synonym: Calcium Isotopes [Chemical/Ingredient]
Synonym: Calcium isotope
Synonym: Calcium isotope (substance)
Synonym: Calcium--Isotopes
Synonym: Isotopes, Calcium
Tree Number: T6.1.9.1
database_cross_reference: LCH_NW:sh85018770
database_cross_reference: MSH:D002127
database_cross_reference: NDFRT:N0000166115
database_cross_reference: SNMI:C-14301
database_cross_reference: SNOMEDCT_US:64974009

Calcium Radioisotopes
type: Class
subclass of: Calcium Isotopes
subclass of: Radioisotopes
MCID: MC00002135
PMOID: PMO:00015329
Subclass_of: Calcium Isotopes
Subclass_of: Radioisotopes
Synonym: Calcium Radioisotopes [Chemical/Ingredient]
Synonym: Calcium radioisotope
Synonym: Calcium radioisotope (substance)
Synonym: Calcium radioisotope, NOS
Synonym: Radioisotopes, Calcium
Tree Number: T6.1.9.1.1
Tree Number: T6.1.9.17.4
database_cross_reference: MSH:D002132
database_cross_reference: NDFRT:N0000166116
database_cross_reference: SNM:E-5222
database_cross_reference: SNMI:C-143A0
database_cross_reference: SNOMEDCT_US:33137005

Magnesium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: Metals, Light
MCID: MC00007817
PMOID: PMO:00015330
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Light
Synonym: Acetabolan III Vitamin and Mineral Supplement
Synonym: Acetabolan-II Vitamin and Mineral Supplement
Synonym: Acti Mag 250 Caplet
Synonym: Acti-cal/mag 2:1 + Zinc and D Caplet
Synonym: Actical Plus Calcium-magnesium-vitamin D3-silicon Chewable
Synonym: Active Calcium Plus Magnesium, Vitamin D and Silicon
Synonym: Actyform
Synonym: Alphaligo
Synonym: Aminosyn 3.5% M
Synonym: Armax
Tree Number: T6.1.10.7.4
Tree Number: T6.1.6.13.4
Tree Number: T6.1.6.7.4
database_cross_reference: AOD:0000005765
database_cross_reference: AOD:0000028711
database_cross_reference: CCPSS:0046813
database_cross_reference: CHV:0000007660
database_cross_reference: CSP:1852-6512
database_cross_reference: CSP:4007-0080
database_cross_reference: DRUGBANK:DB01378
database_cross_reference: LCH:U002778
database_cross_reference: LCH_NW:sh85079651
database_cross_reference: LNC:LP14343-5
database_cross_reference: LNC:MTHU002163
database_cross_reference: MEDCIN:199598
database_cross_reference: MEDLINEPLUS:4298
database_cross_reference: MMSL:5005
database_cross_reference: MMSL:5535
database_cross_reference: MSH:D008274
database_cross_reference: MTH:U002057
database_cross_reference: MTHSPL:I38ZP9992A
database_cross_reference: NCI:C29239
database_cross_reference: NCI_DCP:03072
database_cross_reference: NCI_NCI-GLOSS:CDR0000373087
database_cross_reference: NDDF:000784
database_cross_reference: NDDF:004557
database_cross_reference: NDDF:004558
database_cross_reference: NDDF:004559
database_cross_reference: NDDF:004560
database_cross_reference: NDFRT:N0000006335
database_cross_reference: NDFRT:N0000146038
database_cross_reference: PSY:29110
database_cross_reference: RCD:X80D2
database_cross_reference: RXNORM:6574
database_cross_reference: SNM:F-10400
database_cross_reference: SNMI:C-14800
database_cross_reference: SNOMEDCT_US:72717003
database_cross_reference: USPMG:MTHU001746
database_cross_reference: VANDF:4017660

Strontium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: Metals, Heavy
MCID: MC00012283
PMOID: PMO:00015331
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Heavy
Synonym: STRONTIUM
Synonym: Sr
Synonym: Sr - Strontium
Synonym: Strontium (substance)
Synonym: Strontium [Chemical/Ingredient]
Synonym: Strontium preparation
Synonym: Strontium preparation (product)
Synonym: Strontium, NOS
Synonym: strontium
Tree Number: T6.1.10.4.4
Tree Number: T6.1.10.6.45
Tree Number: T6.1.6.12.45
Tree Number: T6.1.6.7.6
database_cross_reference: AOD:0000019460
database_cross_reference: CHV:0000011785
database_cross_reference: CSP:1852-6564
database_cross_reference: LCH:U004499
database_cross_reference: LCH_NW:sh85129178
database_cross_reference: LNC:LP16835-8
database_cross_reference: LNC:MTHU003499
database_cross_reference: MSH:D013324
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:YZS2RPE8LE
database_cross_reference: NCI:C846
database_cross_reference: NCI_FDA:YZS2RPE8LE
database_cross_reference: NCI_NCI-GLOSS:CDR0000045913
database_cross_reference: NDDF:010549
database_cross_reference: NDFRT:N0000007902
database_cross_reference: RCD:X808l
database_cross_reference: RXNORM:10122
database_cross_reference: SNM:F-10590
database_cross_reference: SNMI:C-15800
database_cross_reference: SNOMEDCT_US:415633000
database_cross_reference: SNOMEDCT_US:43136004

Strontium Isotopes
type: Class
subclass of: Isotopes
MCID: MC00012284
PMOID: PMO:00015332
Subclass_of: Isotopes
Synonym: Isotopes, Strontium
Synonym: Strontium Isotopes [Chemical/Ingredient]
Synonym: Strontium isotope
Synonym: Strontium isotope (substance)
Synonym: Strontium--Isotopes
Tree Number: T6.1.9.19
database_cross_reference: LCH_NW:sh85129179
database_cross_reference: MSH:D013325
database_cross_reference: NDFRT:N0000166127
database_cross_reference: SNMI:C-15801
database_cross_reference: SNOMEDCT_US:44234001

Strontium Radioisotopes
type: Class
subclass of: Strontium Isotopes
subclass of: Radioisotopes
MCID: MC00012285
PMOID: PMO:00015333
Subclass_of: Radioisotopes
Subclass_of: Strontium Isotopes
Synonym: Radioisotopes, Strontium
Synonym: Strontium Radioisotopes [Chemical/Ingredient]
Synonym: Strontium radioisotope
Synonym: Strontium radioisotope (substance)
Synonym: Strontium radioisotope, NOS
Tree Number: T6.1.9.17.31
Tree Number: T6.1.9.19.1
database_cross_reference: MSH:D013326
database_cross_reference: NDFRT:N0000166128
database_cross_reference: SNM:E-5271
database_cross_reference: SNMI:C-158A0
database_cross_reference: SNOMEDCT_US:54179002

Metals, Rare Earth
type: Class
subclass of: Elements
subclass of: Metals
MCID: MC00008138
PMOID: PMO:00015334
Subclass_of: Elements
Subclass_of: Metals
Synonym: Earth Metals, Rare
Synonym: Earths, Rare
Synonym: Metals, Rare Earth [Chemical/Ingredient]
Synonym: Rare Earth Metals
Synonym: Rare earth metal compounds
Synonym: Rare earth metals
Synonym: rare earth
Synonym: rare earth element
Synonym: rare earth elements
Synonym: rare earths
Tree Number: T6.1.10.5
Tree Number: T6.1.6.8
database_cross_reference: AOD:0000019526
database_cross_reference: CHV:0000008006
database_cross_reference: CSP:1853-0057
database_cross_reference: LCH:U004048
database_cross_reference: LCH:U005771
database_cross_reference: LCH:U005772
database_cross_reference: LCH_NW:sh85111458
database_cross_reference: MSH:D008674
database_cross_reference: NDFRT:N0000007993

Scandium
type: Class
subclass of: Metals, Rare Earth
subclass of: Transition Elements
MCID: MC00011622
PMOID: PMO:00015335
Subclass_of: Metals, Rare Earth
Subclass_of: Transition Elements
Synonym: SCANDIUM
Synonym: Scandium [Chemical/Ingredient]
Synonym: scandium
Tree Number: T6.1.10.5.1
Tree Number: T6.1.6.14.22
Tree Number: T6.1.6.8.1
database_cross_reference: AOD:0000019527
database_cross_reference: LCH:U004221
database_cross_reference: LCH_NW:sh85117977
database_cross_reference: LNC:LP28503-8
database_cross_reference: LNC:MTHU014130
database_cross_reference: MSH:D012538
database_cross_reference: MTHSPL:YUJ4U1EW7R
database_cross_reference: NDFRT:N0000166225
database_cross_reference: RXNORM:1311273

Yttrium
type: Class
subclass of: Metals, Rare Earth
subclass of: Transition Elements
MCID: MC00013790
PMOID: PMO:00015336
Subclass_of: Metals, Rare Earth
Subclass_of: Transition Elements
Synonym: Y
Synonym: YTTRIUM
Synonym: Yttrium (substance)
Synonym: Yttrium [Chemical/Ingredient]
Synonym: Yttrium, NOS
Synonym: yttrium
Tree Number: T6.1.10.5.2
Tree Number: T6.1.6.14.29
Tree Number: T6.1.6.8.2
database_cross_reference: AOD:0000019528
database_cross_reference: CHV:0000013265
database_cross_reference: CSP:2551-4006
database_cross_reference: LCH:U005080
database_cross_reference: LCH_NW:sh85149410
database_cross_reference: MSH:D015019
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:58784XQC3Y
database_cross_reference: NCI:C28199
database_cross_reference: NCI_NCI-GLOSS:CDR0000044261
database_cross_reference: NDFRT:N0000166239
database_cross_reference: RXNORM:1534770
database_cross_reference: SNMI:C-16200
database_cross_reference: SNOMEDCT_US:63754004

Yttrium Isotopes
type: Class
subclass of: Isotopes
MCID: MC00013791
PMOID: PMO:00015337
Subclass_of: Isotopes
Synonym: Isotopes, Yttrium
Synonym: Yttrium Isotopes [Chemical/Ingredient]
Synonym: Yttrium isotope
Synonym: Yttrium isotope (substance)
Synonym: Yttrium--Isotopes
Tree Number: T6.1.9.22
database_cross_reference: LCH_NW:sh85149411
database_cross_reference: MSH:D015020
database_cross_reference: NDFRT:N0000166111
database_cross_reference: SNMI:C-16201
database_cross_reference: SNOMEDCT_US:50491009

Yttrium Radioisotopes
type: Class
subclass of: Yttrium Isotopes
subclass of: Radioisotopes
MCID: MC00013792
PMOID: PMO:00015338
Subclass_of: Radioisotopes
Subclass_of: Yttrium Isotopes
Synonym: Radioisotopes, Yttrium
Synonym: Yttrium Radioisotopes [Chemical/Ingredient]
Synonym: Yttrium radioisotope
Synonym: Yttrium radioisotope (substance)
Synonym: Yttrium radioisotope, NOS
Tree Number: T6.1.9.17.37
Tree Number: T6.1.9.22.1
database_cross_reference: MSH:D015021
database_cross_reference: NDFRT:N0000166112
database_cross_reference: SNMI:C-162A0
database_cross_reference: SNOMEDCT_US:68117004

Lanthanoid Series Elements
type: Class
subclass of: Metals, Rare Earth
MCID: MC00067168
PMOID: PMO:00015339
Subclass_of: Metals, Rare Earth
Synonym: Elements, Lanthanoid Series
Synonym: Lanthanides
Synonym: Lanthanoid Series Elements [Chemical/Ingredient]
Synonym: Lanthanoids
Synonym: lanthanide
Tree Number: T6.1.10.5.3
Tree Number: T6.1.6.8.3
database_cross_reference: CSP:1853-0057
database_cross_reference: MSH:D028581
database_cross_reference: NDFRT:N0000011410

Cerium Isotopes
type: Class
subclass of: Isotopes
MCID: MC00002537
PMOID: PMO:00015341
Subclass_of: Isotopes
Synonym: Cerium Isotopes [Chemical/Ingredient]
Synonym: Cerium--Isotopes
Synonym: Isotopes, Cerium
Tree Number: T6.1.9.3
database_cross_reference: LCH_NW:sh85022139
database_cross_reference: MSH:D002564
database_cross_reference: NDFRT:N0000166109

Cerium Radioisotopes
type: Class
subclass of: Cerium Isotopes
subclass of: Radioisotopes
MCID: MC00002538
PMOID: PMO:00015342
Subclass_of: Cerium Isotopes
Subclass_of: Radioisotopes
Synonym: Cerium Radioisotopes [Chemical/Ingredient]
Synonym: Radioisotopes, Cerium
Tree Number: T6.1.9.17.6
Tree Number: T6.1.9.3.1
database_cross_reference: MSH:D002565
database_cross_reference: NDFRT:N0000166110

Lutetium
type: Class
subclass of: Transition Elements
MCID: MC00007725
PMOID: PMO:00015349
Subclass_of: Transition Elements
Synonym: LUTETIUM
Synonym: Lutetium (substance)
Synonym: Lutetium [Chemical/Ingredient]
Synonym: lutetium
Tree Number: T6.1.6.14.10
database_cross_reference: AOD:0000019543
database_cross_reference: CHV:0000007583
database_cross_reference: LCH:U002751
database_cross_reference: LCH_NW:sh85078994
database_cross_reference: MSH:D008187
database_cross_reference: MTHSPL:5H0DOZ21UJ
database_cross_reference: NDFRT:N0000166227
database_cross_reference: RXNORM:1534772
database_cross_reference: SNOMEDCT_US:447191008

Nitrogen
type: Class
subclass of: Elements
subclass of: Gases
MCID: MC00008936
PMOID: PMO:00015356
Subclass_of: Elements
Subclass_of: Gases
Synonym: Air USP
Synonym: Carbon Dioxide Mixture
Synonym: Carbon Monox, Helium, Oxygen, Nitrogen L.D.M.
Synonym: Co-HE-O2-N2 Mixture
Synonym: Co-NE-O2-N2 Mixture
Synonym: Compressed Gas N.O.S.
Synonym: Gaseous Nitrogen 99.0%
Synonym: Helium Oxygen Nitrogen mixture
Synonym: Hyperbaric Chamber Mix
Synonym: Liquid Nitrogen Nf
Tree Number: T6.1.6.9
Tree Number: T6.1.8.9
database_cross_reference: AOD:0000001947
database_cross_reference: ATC:V03AN04
database_cross_reference: CHV:0000008740
database_cross_reference: CSP:2076-7824
database_cross_reference: DRUGBANK:DB09152
database_cross_reference: LCH:U003246
database_cross_reference: LCH_NW:sh85092062
database_cross_reference: LNC:LP15746-8
database_cross_reference: LNC:MTHU006085
database_cross_reference: MSH:D009584
database_cross_reference: MTH:U002109
database_cross_reference: MTHSPL:N762921K75
database_cross_reference: NCI:C61863
database_cross_reference: NCI_FDA:N762921K75
database_cross_reference: NDDF:002515
database_cross_reference: NDFRT:N0000006654
database_cross_reference: NDFRT:N0000147408
database_cross_reference: PSY:34070
database_cross_reference: RCD:X799L
database_cross_reference: RXNORM:7456
database_cross_reference: SNM:F-10440
database_cross_reference: SNMI:C-10700
database_cross_reference: SNOMEDCT_US:36012007
database_cross_reference: VANDF:4019163

Nitrogen Isotopes
type: Class
subclass of: Nitrogen
subclass of: Isotopes
MCID: MC00008940
PMOID: PMO:00015357
Subclass_of: Isotopes
Subclass_of: Nitrogen
Synonym: Isotopes, Nitrogen
Synonym: Nitrogen Isotopes [Chemical/Ingredient]
Synonym: Nitrogen isotope
Synonym: Nitrogen isotope (substance)
Synonym: Nitrogen--Isotopes
Tree Number: T6.1.6.9.1
Tree Number: T6.1.8.9.1
Tree Number: T6.1.9.13
database_cross_reference: LCH_NW:sh85092064
database_cross_reference: MSH:D009587
database_cross_reference: NDFRT:N0000166145
database_cross_reference: SNMI:C-10701
database_cross_reference: SNOMEDCT_US:86575005

Nitrogen Radioisotopes
type: Class
subclass of: Nitrogen Isotopes
subclass of: Radioisotopes
MCID: MC00008942
PMOID: PMO:00015358
Subclass_of: Nitrogen Isotopes
Subclass_of: Radioisotopes
Synonym: Nitrogen Radioisotopes [Chemical/Ingredient]
Synonym: Nitrogen radioisotope
Synonym: Nitrogen radioisotope (substance)
Synonym: Nitrogen radioisotope, NOS
Synonym: Radioisotopes, Nitrogen
Tree Number: T6.1.9.13.1
Tree Number: T6.1.9.17.22
database_cross_reference: MSH:D009590
database_cross_reference: NDFRT:N0000166146
database_cross_reference: SNM:E-5071
database_cross_reference: SNMI:C-107A0
database_cross_reference: SNOMEDCT_US:86710005

Phosphorus
type: Class
subclass of: Elements
MCID: MC00010151
PMOID: PMO:00015359
Subclass_of: Elements
Synonym: P
Synonym: P element
Synonym: PHOSPHORUS
Synonym: Phosphoric
Synonym: Phosphorous
Synonym: Phosphorous (NOS)
Synonym: Phosphorus (substance)
Synonym: Phosphorus [Chemical/Ingredient]
Synonym: Phosphorus, NOS
Synonym: mineral supplements phosphorus preparations
Tree Number: T6.1.6.10
database_cross_reference: AOD:0000001941
database_cross_reference: CHV:0000009676
database_cross_reference: CSP:2301-3551
database_cross_reference: LCH:U003643
database_cross_reference: LCH_NW:sh85101119
database_cross_reference: LNC:MTHU014112
database_cross_reference: MEDCIN:41245
database_cross_reference: MEDLINEPLUS:4298
database_cross_reference: MMSL:5295
database_cross_reference: MSH:D010758
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:27YLU75U4W
database_cross_reference: NCI:C28375
database_cross_reference: NCI:C47934
database_cross_reference: NCI_DCP:31089
database_cross_reference: NCI_NCI-GLOSS:CDR0000044340
database_cross_reference: NCI_NCI-GLOSS:CDR0000044356
database_cross_reference: NDDF:000863
database_cross_reference: NDFRT:N0000006920
database_cross_reference: NDFRT:N0000146063
database_cross_reference: PSY:38370
database_cross_reference: RCD:X796m
database_cross_reference: RXNORM:8263
database_cross_reference: SNM:F-10510
database_cross_reference: SNMI:C-10600
database_cross_reference: SNOMEDCT_US:30820000
database_cross_reference: VANDF:4017689

Phosphorus Isotopes
type: Class
subclass of: Phosphorus
subclass of: Isotopes
MCID: MC00010152
PMOID: PMO:00015360
Subclass_of: Isotopes
Subclass_of: Phosphorus
Synonym: Isotopes, Phosphorus
Synonym: Phosphorus Isotopes [Chemical/Ingredient]
Synonym: Phosphorus isotope
Synonym: Phosphorus isotope (substance)
Synonym: Phosphorus--Isotopes
Tree Number: T6.1.6.10.1
Tree Number: T6.1.9.15
database_cross_reference: LCH_NW:sh85101120
database_cross_reference: MSH:D010759
database_cross_reference: NDFRT:N0000166125
database_cross_reference: SNMI:C-10601
database_cross_reference: SNOMEDCT_US:7156005

Phosphorus Radioisotopes
type: Class
subclass of: Phosphorus Isotopes
subclass of: Radioisotopes
MCID: MC00010154
PMOID: PMO:00015361
Subclass_of: Phosphorus Isotopes
Subclass_of: Radioisotopes
Synonym: Phosphorus Radioisotopes [Chemical/Ingredient]
Synonym: Phosphorus radioisotope
Synonym: Phosphorus radioisotope (substance)
Synonym: Phosphorus radioisotope, NOS
Synonym: Radioisotopes, Phosphorus
Tree Number: T6.1.9.15.1
Tree Number: T6.1.9.17.24
database_cross_reference: MSH:D010761
database_cross_reference: NDFRT:N0000166126
database_cross_reference: SNM:E-5097
database_cross_reference: SNMI:C-106A0
database_cross_reference: SNOMEDCT_US:77923008

Chalcogens
type: Class
subclass of: Elements
MCID: MC00067592
PMOID: PMO:00015362
Subclass_of: Elements
Synonym: Chalcogens [Chemical/Ingredient]
Synonym: Elements, Group 16
Synonym: Group 16 Elements
Tree Number: T6.1.6.11
database_cross_reference: LCH_NW:sh2002008811
database_cross_reference: MSH:D018011
database_cross_reference: NDFRT:N0000007935

Oxygen
type: Class
subclass of: Chalcogens
subclass of: Gases
MCID: MC00009581
PMOID: PMO:00015363
Subclass_of: Chalcogens
Subclass_of: Gases
Synonym: Air Compressed Medical Air
Synonym: Air USP
Synonym: Alnox Gas
Synonym: Carbon Dioxide 1% W Oxygen
Synonym: Carbon Dioxide 12.1% W Oxygen
Synonym: Carbon Dioxide 23.1% W Oxygen
Synonym: Carbon Dioxide 7.1% W Oxygen
Synonym: Carbon Dioxide Mixture
Synonym: Carbon Dioxide Oxygen Mix
Synonym: Carbon Dioxide Oxygen Mixture 5/95
Tree Number: T6.1.6.11.1
Tree Number: T6.1.8.11
database_cross_reference: AOD:0000001289
database_cross_reference: ATC:V03AN01
database_cross_reference: CHV:0000009153
database_cross_reference: CSP:2189-1281
database_cross_reference: DRUGBANK:DB09140
database_cross_reference: LCH:U003425
database_cross_reference: LCH_NW:sh85096329
database_cross_reference: LNC:LP14536-4
database_cross_reference: LNC:LP99292-2
database_cross_reference: LNC:MTHU002757
database_cross_reference: MMSL:d06860
database_cross_reference: MSH:D010100
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000131
database_cross_reference: MTH:U000187
database_cross_reference: MTHSPL:S88TT14065
database_cross_reference: NCI:C722
database_cross_reference: NCI_FDA:S88TT14065
database_cross_reference: NCI_NCI-GLOSS:CDR0000538149
database_cross_reference: NDDF:000826
database_cross_reference: NDFRT:N0000006405
database_cross_reference: NDFRT:N0000147362
database_cross_reference: PSY:36090
database_cross_reference: RCD:XM0l9
database_cross_reference: RXNORM:7806
database_cross_reference: SNM:F-10470
database_cross_reference: SNMI:C-10110
database_cross_reference: SNOMEDCT_US:24099007
database_cross_reference: VANDF:4019105

Oxygen Isotopes
type: Class
subclass of: Oxygen
subclass of: Isotopes
MCID: MC00009582
PMOID: PMO:00015364
Subclass_of: Isotopes
Subclass_of: Oxygen
Synonym: Isotopes, Oxygen
Synonym: Oxygen Isotopes [Chemical/Ingredient]
Synonym: Oxygen isotope
Synonym: Oxygen isotope (substance)
Synonym: Oxygen--Isotopes
Tree Number: T6.1.8.11.1
Tree Number: T6.1.9.14
database_cross_reference: LCH_NW:sh85096331
database_cross_reference: MSH:D010103
database_cross_reference: NDFRT:N0000166113
database_cross_reference: SNOMEDCT_US:722230006

Oxygen Radioisotopes
type: Class
subclass of: Oxygen Isotopes
subclass of: Radioisotopes
MCID: MC00009583
PMOID: PMO:00015365
Subclass_of: Oxygen Isotopes
Subclass_of: Radioisotopes
Synonym: Oxygen Radioisotopes [Chemical/Ingredient]
Synonym: Oxygen radioisotope
Synonym: Oxygen radioisotope (substance)
Synonym: Radioisotopes, Oxygen
Tree Number: T6.1.9.14.1
Tree Number: T6.1.9.17.23
database_cross_reference: MSH:D010104
database_cross_reference: NDFRT:N0000166114
database_cross_reference: SNM:E-5018
database_cross_reference: SNMI:C-10111
database_cross_reference: SNOMEDCT_US:6038004

Selenium
type: Class
subclass of: Chalcogens
subclass of: Minerals
MCID: MC00011715
PMOID: PMO:00015366
Subclass_of: Chalcogens
Subclass_of: Minerals
Synonym: A.R.T.H. Away Formula
Synonym: B-Traxim Se
Synonym: Cell-wise
Synonym: Cell-wise Natural Source
Synonym: Complete Multivitamins and Minerals Tablets Timed Release
Synonym: Enviroflex - Tab
Synonym: Formula 14 Dietary Supplement
Synonym: Formula CF
Synonym: Formula Im-vitamins and Minerals Tab
Synonym: Formula Inf
Tree Number: T6.1.11.5
Tree Number: T6.1.6.11.3
database_cross_reference: AOD:0000019484
database_cross_reference: CHV:0000011166
database_cross_reference: CSP:1852-9448
database_cross_reference: DRUGBANK:DB11127
database_cross_reference: DRUGBANK:DB11135
database_cross_reference: LCH:U004254
database_cross_reference: LCH_NW:sh85119688
database_cross_reference: LNC:LP14283-3
database_cross_reference: LNC:MTHU007657
database_cross_reference: MEDCIN:250039
database_cross_reference: MEDLINEPLUS:4298
database_cross_reference: MMSL:10641
database_cross_reference: MMSL:5450
database_cross_reference: MMSL:d00484
database_cross_reference: MSH:D012643
database_cross_reference: MTH:U002234
database_cross_reference: MTHSPL:H6241UJ22B
database_cross_reference: NCI:C825
database_cross_reference: NCI_DCP:00930
database_cross_reference: NCI_FDA:H6241UJ22B
database_cross_reference: NCI_NCI-GLOSS:CDR0000045113
database_cross_reference: NDDF:000864
database_cross_reference: NDFRT:N0000006104
database_cross_reference: NDFRT:N0000148196
database_cross_reference: PDQ:CDR0000038725
database_cross_reference: RCD:X7987
database_cross_reference: RCD:x01Fn
database_cross_reference: RXNORM:9641
database_cross_reference: SNMI:C-11600
database_cross_reference: SNOMEDCT_US:22038003
database_cross_reference: SNOMEDCT_US:350057002
database_cross_reference: USPMG:MTHU001145
database_cross_reference: VANDF:4020392

Sulfur
type: Class
subclass of: Chalcogens
MCID: MC00012410
PMOID: PMO:00015367
Subclass_of: Chalcogens
Synonym: 5s Blemish Treatment
Synonym: Acne Aid Gel
Synonym: Acne Blemish Cream(sulfur Cream)
Synonym: Acne Clearning Treatment Face
Synonym: Acne LotionSulfur Sulfur
Synonym: Acne Treatment Sulfur Wash Rodan and Field
Synonym: Acne Treatment maximum strength CVS
Synonym: Acnefree Therapeutic Sulfur Mask
Synonym: Acnomel Skin Tone Cream
Synonym: Actinac Pwr
Tree Number: T6.1.6.11.4
database_cross_reference: AOD:0000019483
database_cross_reference: ATC:D10AB02
database_cross_reference: CHV:0000011874
database_cross_reference: CSP:4000-0342
database_cross_reference: DRUGBANK:DB09353
database_cross_reference: LCH_NW:sh85130365
database_cross_reference: MEDCIN:40705
database_cross_reference: MMSL:5415
database_cross_reference: MMSL:5534
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D013455
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:70FD1KFU70
database_cross_reference: NDDF:002558
database_cross_reference: NDDF:002997
database_cross_reference: NDFRT:N0000007000
database_cross_reference: NDFRT:N0000147169
database_cross_reference: RCD:Xa4kH
database_cross_reference: RCD:m63..
database_cross_reference: RCDAE:Xa4kH
database_cross_reference: RCDAE:m63..
database_cross_reference: RXNORM:10223
database_cross_reference: SNM:F-10610
database_cross_reference: SNMI:C-10800
database_cross_reference: SNOMEDCT_US:332304007
database_cross_reference: SNOMEDCT_US:43735007
database_cross_reference: VANDF:4018870

Sulfur Isotopes
type: Class
subclass of: Isotopes
MCID: MC00012415
PMOID: PMO:00015368
Subclass_of: Isotopes
Synonym: Isotopes, Sulfur
Synonym: Sulfur Isotopes [Chemical/Ingredient]
Synonym: Sulfur isotope
Synonym: Sulfur isotope (substance)
Synonym: Sulfur--Isotopes
Synonym: Sulphur isotope
Tree Number: T6.1.9.20
database_cross_reference: LCH_NW:sh85130366
database_cross_reference: MSH:D013460
database_cross_reference: NDFRT:N0000166133
database_cross_reference: SNMI:C-10801
database_cross_reference: SNOMEDCT_US:7985000

Sulfur Radioisotopes
type: Class
subclass of: Sulfur Isotopes
subclass of: Radioisotopes
MCID: MC00012417
PMOID: PMO:00015369
Subclass_of: Radioisotopes
Subclass_of: Sulfur Isotopes
Synonym: Radioisotopes, Sulfur
Synonym: Sulfur Radioisotopes [Chemical/Ingredient]
Synonym: Sulfur radioisotope
Synonym: Sulfur radioisotope (substance)
Synonym: Sulfur radioisotope, NOS
Synonym: Sulphur radioisotope
Tree Number: T6.1.9.17.32
Tree Number: T6.1.9.20.1
database_cross_reference: MSH:D013462
database_cross_reference: NDFRT:N0000166134
database_cross_reference: SNM:E-5081
database_cross_reference: SNMI:C-108A0
database_cross_reference: SNOMEDCT_US:88287006

Tellurium
type: Class
subclass of: Chalcogens
subclass of: Metalloids
MCID: MC00012588
PMOID: PMO:00015370
Subclass_of: Chalcogens
Subclass_of: Metalloids
Synonym: TELLURIUM
Synonym: Te
Synonym: Te element
Synonym: Tellurium (substance)
Synonym: Tellurium Metallicum
Synonym: Tellurium [Chemical/Ingredient]
Synonym: Tellurium metallicum / tellurium
Synonym: Tellurium, NOS
Synonym: te
Synonym: tellurium
Tree Number: T6.1.6.11.5
Tree Number: T6.1.6.15.7
database_cross_reference: ALT:HATAL
database_cross_reference: AOD:0000019485
database_cross_reference: CHV:0000012080
database_cross_reference: CSP:1852-9515
database_cross_reference: LCH:U004601
database_cross_reference: LCH_NW:sh85133642
database_cross_reference: LNC:LP16836-6
database_cross_reference: LNC:MTHU003500
database_cross_reference: MSH:D013691
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NQA0O090ZJ
database_cross_reference: NCI:C95192
database_cross_reference: NCI_FDA:NQA0O090ZJ
database_cross_reference: NDFRT:N0000166176
database_cross_reference: RXNORM:1311384
database_cross_reference: SNMI:C-11700
database_cross_reference: SNOMEDCT_US:41577000

Metals, Heavy
type: Class
subclass of: Elements
subclass of: Metals
MCID: MC00124017
PMOID: PMO:00015371
Subclass_of: Elements
Subclass_of: Metals
Synonym: Heavy Metals
Synonym: Heavy metal
Synonym: Heavy metal (substance)
Synonym: Heavy metal, NOS
Synonym: Heavy metals
Synonym: Metals, Heavy [Chemical/Ingredient]
Synonym: heavy metal
Synonym: heavy metals
Tree Number: T6.1.10.6
Tree Number: T6.1.6.12
database_cross_reference: CHV:0000031162
database_cross_reference: CSP:1852-7783
database_cross_reference: LCH_NW:sh85059851
database_cross_reference: LNC:LP14257-7
database_cross_reference: LNC:MTHU011486
database_cross_reference: MSH:D019216
database_cross_reference: NDFRT:N0000008098
database_cross_reference: RCD:X79AM
database_cross_reference: SNM:E-5290
database_cross_reference: SNMI:C-11820
database_cross_reference: SNOMEDCT_US:22907001

Antimony
type: Class
subclass of: Metals, Heavy
subclass of: Metalloids
MCID: MC00001084
PMOID: PMO:00015372
Subclass_of: Metalloids
Subclass_of: Metals, Heavy
Synonym: ANTIMONY
Synonym: Antimony (product)
Synonym: Antimony (substance)
Synonym: Antimony Metallicum
Synonym: Antimony [Chemical/Ingredient]
Synonym: Antimony, NOS
Synonym: Sb
Synonym: Sb - Antimony
Synonym: Sb element
Synonym: antimony
Tree Number: T6.1.10.6.3
Tree Number: T6.1.6.12.3
Tree Number: T6.1.6.15.1
database_cross_reference: AOD:0000019480
database_cross_reference: CHV:0000001309
database_cross_reference: CSP:1852-9349
database_cross_reference: DRUGBANK:DB13110
database_cross_reference: LCH:U000299
database_cross_reference: LCH_NW:sh85005702
database_cross_reference: LNC:LP16801-0
database_cross_reference: LNC:MTHU002647
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000965
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9IT35J3UV3
database_cross_reference: NCI:C95187
database_cross_reference: NCI_FDA:9IT35J3UV3
database_cross_reference: NDDF:006221
database_cross_reference: NDFRT:N0000166272
database_cross_reference: RCD:X808Z
database_cross_reference: RXNORM:1311407
database_cross_reference: SNMI:C-12100
database_cross_reference: SNOMEDCT_US:421045002
database_cross_reference: SNOMEDCT_US:42449005

Cadmium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00002087
PMOID: PMO:00015373
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: CADMIUM
Synonym: Cadmium (substance)
Synonym: Cadmium Metal
Synonym: Cadmium [Chemical/Ingredient]
Synonym: Cadmium, NOS
Synonym: Cd
Synonym: Cd - Cadmium
Synonym: Cd element
Synonym: cadmium
Synonym: cadmium (Cd)
Tree Number: T6.1.10.6.7
Tree Number: T6.1.6.12.7
Tree Number: T6.1.6.14.1
database_cross_reference: AOD:0000019465
database_cross_reference: CHV:0000002279
database_cross_reference: CSP:1852-7850
database_cross_reference: LCH:U000735
database_cross_reference: LCH_NW:sh85018635
database_cross_reference: LNC:LP16810-1
database_cross_reference: LNC:MTHU003442
database_cross_reference: MSH:D002104
database_cross_reference: MTH:U001771
database_cross_reference: MTHSPL:00BH33GNGH
database_cross_reference: NCI:C44348
database_cross_reference: NCI_FDA:00BH33GNGH
database_cross_reference: NCI_NCI-GLOSS:CDR0000344348
database_cross_reference: NDFRT:N0000166266
database_cross_reference: RCD:X7952
database_cross_reference: RXNORM:1362694
database_cross_reference: SNM:E-5152
database_cross_reference: SNMI:C-12600
database_cross_reference: SNOMEDCT_US:66586000

Chromium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00002808
PMOID: PMO:00015374
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Accelerator
Synonym: Actichrom
Synonym: Advanced 2000 Capsules
Synonym: Bio-chrome
Synonym: Biosculpt
Synonym: CHROMIUM
Synonym: Calcium Complex High Grade
Synonym: Calcium With Mg Zn Mn Cu CR Si and Vit. C & D
Synonym: Carbaway
Synonym: Chela-chromium 200
Tree Number: T6.1.10.6.10
Tree Number: T6.1.6.12.10
Tree Number: T6.1.6.14.2
database_cross_reference: AOD:0000019504
database_cross_reference: CHV:0000002935
database_cross_reference: CSP:1852-7917
database_cross_reference: DRUGBANK:DB09129
database_cross_reference: DRUGBANK:DB11136
database_cross_reference: LCH:U001009
database_cross_reference: LCH_NW:sh85025350
database_cross_reference: LNC:LP16812-7
database_cross_reference: LNC:MTHU005181
database_cross_reference: MDR:10008797
database_cross_reference: MEDCIN:250035
database_cross_reference: MMSL:4440
database_cross_reference: MMSL:8627
database_cross_reference: MSH:D002857
database_cross_reference: MTH:U001814
database_cross_reference: MTHSPL:0R0008Q3JB
database_cross_reference: NCI:C370
database_cross_reference: NDDF:000861
database_cross_reference: NDFRT:N0000006135
database_cross_reference: NDFRT:N0000146088
database_cross_reference: RCD:X80RB
database_cross_reference: RXNORM:2496
database_cross_reference: SNM:F-10260
database_cross_reference: SNMI:C-12900
database_cross_reference: SNOMEDCT_US:111070004
database_cross_reference: VANDF:4017719

Chromium Isotopes
type: Class
subclass of: Isotopes
MCID: MC00002812
PMOID: PMO:00015375
Subclass_of: Isotopes
Synonym: Chromium Isotopes [Chemical/Ingredient]
Synonym: Chromium isotope
Synonym: Chromium isotope (substance)
Synonym: Chromium--Isotopes
Synonym: Isotopes, Chromium
Tree Number: T6.1.9.5
database_cross_reference: LCH_NW:sh85025351
database_cross_reference: MSH:D002859
database_cross_reference: NDFRT:N0000166141
database_cross_reference: SNMI:C-12901
database_cross_reference: SNOMEDCT_US:67266008

Chromium Radioisotopes
type: Class
subclass of: Chromium Isotopes
subclass of: Radioisotopes
MCID: MC00002813
PMOID: PMO:00015376
Subclass_of: Chromium Isotopes
Subclass_of: Radioisotopes
Synonym: Chromium Radioisotopes [Chemical/Ingredient]
Synonym: Chromium radioisotope
Synonym: Chromium radioisotope (substance)
Synonym: Chromium radioisotope, NOS
Synonym: Radioisotopes, Chromium
Tree Number: T6.1.9.17.8
Tree Number: T6.1.9.5.1
database_cross_reference: MSH:D002860
database_cross_reference: NDFRT:N0000166142
database_cross_reference: SNM:E-5164
database_cross_reference: SNMI:C-129A0
database_cross_reference: SNOMEDCT_US:111071000

Cobalt
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00003009
PMOID: PMO:00015377
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: COBALT
Synonym: Co
Synonym: Co - Cobalt
Synonym: Co element
Synonym: Cobalt (substance)
Synonym: Cobalt [Chemical/Ingredient]
Synonym: Cobalt, NOS
Synonym: Cobaltum metallicum / cobalt
Synonym: cobalt
Synonym: cobalt (Co)
Tree Number: T6.1.10.6.11
Tree Number: T6.1.6.12.11
Tree Number: T6.1.6.14.3
database_cross_reference: ALT:HACEO
database_cross_reference: AOD:0000019506
database_cross_reference: AOD:0000028720
database_cross_reference: CHV:0000003094
database_cross_reference: CSP:1852-7984
database_cross_reference: LCH:U001066
database_cross_reference: LCH_NW:sh85027513
database_cross_reference: LNC:LP14368-2
database_cross_reference: LNC:MTHU005182
database_cross_reference: MSH:D003035
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:3G0H8C9362
database_cross_reference: NCI:C382
database_cross_reference: NCI_FDA:3G0H8C9362
database_cross_reference: NDDF:004707
database_cross_reference: NDFRT:N0000006610
database_cross_reference: NDFRT:N0000022936
database_cross_reference: PSY:09920
database_cross_reference: RCD:X79A6
database_cross_reference: RXNORM:1310300
database_cross_reference: SNM:E-5228
database_cross_reference: SNM:F-10250
database_cross_reference: SNMI:C-14400
database_cross_reference: SNOMEDCT_US:54808007
database_cross_reference: VANDF:4020826

Cobalt Isotopes
type: Class
subclass of: Isotopes
MCID: MC00003012
PMOID: PMO:00015378
Subclass_of: Isotopes
Synonym: Cobalt Isotopes [Chemical/Ingredient]
Synonym: Cobalt isotope
Synonym: Cobalt isotope (substance)
Synonym: Cobalt--Isotopes
Synonym: Isotopes, Cobalt
Tree Number: T6.1.9.6
database_cross_reference: LCH_NW:sh85027514
database_cross_reference: MSH:D003036
database_cross_reference: NDFRT:N0000166123
database_cross_reference: SNMI:C-14401
database_cross_reference: SNOMEDCT_US:1603001

Cobalt Radioisotopes
type: Class
subclass of: Cobalt Isotopes
subclass of: Radioisotopes
MCID: MC00003013
PMOID: PMO:00015379
Subclass_of: Cobalt Isotopes
Subclass_of: Radioisotopes
Synonym: Cobalt Radioisotopes [Chemical/Ingredient]
Synonym: Cobalt radioisotope
Synonym: Cobalt radioisotope (substance)
Synonym: Cobalt radioisotope, NOS
Synonym: Radioisotopes, Cobalt
Tree Number: T6.1.9.17.9
Tree Number: T6.1.9.6.1
database_cross_reference: MSH:D003037
database_cross_reference: NDFRT:N0000166124
database_cross_reference: SNM:E-5229
database_cross_reference: SNMI:C-144A0
database_cross_reference: SNOMEDCT_US:78870008

Copper
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00003244
PMOID: PMO:00015380
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: A.R.T.H. Away Formula
Synonym: Actyform
Synonym: B & J Formula Dietary Supplement
Synonym: C.A.G. Tab
Synonym: COPPER
Synonym: Cal Mag Plus - Tab
Synonym: Calcium Plus
Synonym: Calcium With Mg Zn Mn Cu CR Si and Vit. C & D
Synonym: Calplus
Synonym: Carti-aide Tab
Tree Number: T6.1.10.6.12
Tree Number: T6.1.6.12.12
Tree Number: T6.1.6.14.4
database_cross_reference: AOD:0000005761
database_cross_reference: AOD:0000028721
database_cross_reference: CHV:0000003343
database_cross_reference: CHV:0000055213
database_cross_reference: CSP:1852-8118
database_cross_reference: DRUGBANK:DB09130
database_cross_reference: DRUGBANK:DB09131
database_cross_reference: LCH:U001157
database_cross_reference: LCH_NW:sh85032278
database_cross_reference: LNC:LP16814-3
database_cross_reference: LNC:MTHU003471
database_cross_reference: MEDCIN:250030
database_cross_reference: MEDLINEPLUS:4298
database_cross_reference: MMSL:127948
database_cross_reference: MMSL:4501
database_cross_reference: MMSL:NOCODE
database_cross_reference: MMSL:d07505
database_cross_reference: MSH:D003300
database_cross_reference: MTH:U001827
database_cross_reference: MTHSPL:789U1901C5
database_cross_reference: NCI:C391
database_cross_reference: NCI_DCP:03574
database_cross_reference: NCI_FDA:789U1901C5
database_cross_reference: NDDF:000853
database_cross_reference: NDFRT:N0000005747
database_cross_reference: NDFRT:N0000146034
database_cross_reference: PSY:11800
database_cross_reference: RCD:X795J
database_cross_reference: RXNORM:2837
database_cross_reference: SNM:F-10270
database_cross_reference: SNMI:C-12700
database_cross_reference: SNOMEDCT_US:422528000
database_cross_reference: SNOMEDCT_US:66925006
database_cross_reference: VANDF:4017655

Gallium
type: Class
subclass of: Metals, Heavy
MCID: MC00005398
PMOID: PMO:00015381
Subclass_of: Metals, Heavy
Synonym: GALLIUM
Synonym: Ga
Synonym: Ga element
Synonym: Gallium (substance)
Synonym: Gallium [Chemical/Ingredient]
Synonym: Gallium, NOS
Synonym: ga
Synonym: gallium
Synonym: gallium(Ga)
Tree Number: T6.1.10.6.17
Tree Number: T6.1.6.12.17
database_cross_reference: AOD:0000019470
database_cross_reference: CHV:0000005325
database_cross_reference: CSP:1852-8185
database_cross_reference: DRUGBANK:DB06784
database_cross_reference: LCH:U001904
database_cross_reference: LCH_NW:sh85052848
database_cross_reference: LNC:LP16820-0
database_cross_reference: LNC:MTHU002891
database_cross_reference: MSH:D005708
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:CH46OC8YV4
database_cross_reference: NCI:C66798
database_cross_reference: NCI_FDA:CH46OC8YV4
database_cross_reference: NDDF:004829
database_cross_reference: NDFRT:N0000007939
database_cross_reference: RXNORM:1310124
database_cross_reference: SNMI:C-13100
database_cross_reference: SNOMEDCT_US:62543003

Gallium Isotopes
type: Class
subclass of: Isotopes
MCID: MC00005399
PMOID: PMO:00015382
Subclass_of: Isotopes
Synonym: Gallium Isotopes [Chemical/Ingredient]
Synonym: Gallium isotope
Synonym: Gallium isotope (substance)
Synonym: Gallium--Isotopes
Synonym: Isotopes, Gallium
Tree Number: T6.1.9.8
database_cross_reference: LCH_NW:sh85052850
database_cross_reference: MSH:D005709
database_cross_reference: NDFRT:N0000166143
database_cross_reference: SNMI:C-13101
database_cross_reference: SNOMEDCT_US:4231000

Gallium Radioisotopes
type: Class
subclass of: Gallium Isotopes
subclass of: Radioisotopes
MCID: MC00005400
PMOID: PMO:00015383
Subclass_of: Gallium Isotopes
Subclass_of: Radioisotopes
Synonym: Gallium Radioisotopes [Chemical/Ingredient]
Synonym: Gallium radioisotope
Synonym: Gallium radioisotope (substance)
Synonym: Gallium radioisotope, NOS
Synonym: Radioisotopes, Gallium
Tree Number: T6.1.9.17.13
Tree Number: T6.1.9.8.1
database_cross_reference: MSH:D005710
database_cross_reference: NDFRT:N0000166144
database_cross_reference: SNM:E-5174
database_cross_reference: SNMI:C-131A0
database_cross_reference: SNOMEDCT_US:26095004

Germanium
type: Class
subclass of: Metals, Heavy
subclass of: Metalloids
MCID: MC00005582
PMOID: PMO:00015384
Subclass_of: Metalloids
Subclass_of: Metals, Heavy
Synonym: GERMANIUM
Synonym: Ge
Synonym: Ge element
Synonym: Germanium (substance)
Synonym: Germanium Metallicum
Synonym: Germanium [Chemical/Ingredient]
Synonym: Germanium, NOS
Synonym: ge
Synonym: germanium
Synonym: germanium (Ge)
Tree Number: T6.1.10.6.18
Tree Number: T6.1.6.12.18
Tree Number: T6.1.6.15.4
database_cross_reference: AOD:0000019475
database_cross_reference: CHV:0000005473
database_cross_reference: CSP:1852-8218
database_cross_reference: LCH:U001952
database_cross_reference: LCH_NW:sh85054449
database_cross_reference: LNC:LP16821-8
database_cross_reference: LNC:MTHU022374
database_cross_reference: MEDCIN:250038
database_cross_reference: MSH:D005857
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:00072J7XWS
database_cross_reference: NCI:C95170
database_cross_reference: NCI_FDA:00072J7XWS
database_cross_reference: NDFRT:N0000166255
database_cross_reference: NDFRT:N0000176163
database_cross_reference: RXNORM:4784
database_cross_reference: SNMI:C-12800
database_cross_reference: SNOMEDCT_US:79061004
database_cross_reference: VANDF:4027690

Gold
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00005785
PMOID: PMO:00015385
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Assay of gold
Synonym: Au
Synonym: Au - Gold
Synonym: Au element
Synonym: GOLD
Synonym: Gold (substance)
Synonym: Gold [Chemical/Ingredient]
Synonym: Gold, NOS
Synonym: Golds
Synonym: gold
Tree Number: T6.1.10.6.19
Tree Number: T6.1.6.12.19
Tree Number: T6.1.6.14.5
database_cross_reference: AOD:0000019524
database_cross_reference: CHV:0000005645
database_cross_reference: CSP:1852-8252
database_cross_reference: HCPCS:G6035
database_cross_reference: LCH:U002018
database_cross_reference: LCH:U002021
database_cross_reference: LCH_NW:sh85055692
database_cross_reference: LNC:LP16822-6
database_cross_reference: LNC:MTHU005003
database_cross_reference: MEDCIN:40222
database_cross_reference: MMSL:8796
database_cross_reference: MSH:D006046
database_cross_reference: MTH:U001966
database_cross_reference: MTHSPL:79Y1949PYO
database_cross_reference: NCI:C2392
database_cross_reference: NCI_FDA:79Y1949PYO
database_cross_reference: NDFRT:N0000005996
database_cross_reference: NDFRT:N0000022608
database_cross_reference: RCD:X795i
database_cross_reference: RXNORM:1311190
database_cross_reference: SNM:F-10290
database_cross_reference: SNMI:C-14600
database_cross_reference: SNOMEDCT_US:2309006
database_cross_reference: VANDF:4019622

Gold Isotopes
type: Class
subclass of: Isotopes
MCID: MC00005788
PMOID: PMO:00015386
Subclass_of: Isotopes
Synonym: Gold Isotopes [Chemical/Ingredient]
Synonym: Gold isotope
Synonym: Gold isotope (substance)
Synonym: Gold--Isotopes
Synonym: Isotopes, Gold
Tree Number: T6.1.9.9
database_cross_reference: LCH_NW:sh85055695
database_cross_reference: MSH:D006049
database_cross_reference: NDFRT:N0000166135
database_cross_reference: SNMI:C-14601
database_cross_reference: SNOMEDCT_US:5670008

Gold Radioisotopes
type: Class
subclass of: Gold Isotopes
subclass of: Radioisotopes
MCID: MC00005789
PMOID: PMO:00015387
Subclass_of: Gold Isotopes
Subclass_of: Radioisotopes
Synonym: Gold Radioisotopes [Chemical/Ingredient]
Synonym: Gold radioisotope
Synonym: Gold radioisotope (substance)
Synonym: Gold radioisotope, NOS
Synonym: Radioisotopes, Gold
Tree Number: T6.1.9.17.14
Tree Number: T6.1.9.9.1
database_cross_reference: MSH:D006050
database_cross_reference: NDFRT:N0000166136
database_cross_reference: SNM:E-5232
database_cross_reference: SNMI:C-146A0
database_cross_reference: SNOMEDCT_US:14330001

Gold Colloid, Radioactive
type: Class
subclass of: Gold Colloid
MCID: MC00005787
PMOID: PMO:00015388
Subclass_of: Gold Colloid
Synonym: Colloid, Radioactive Gold
Synonym: Gold Colloid, Radioactive [Chemical/Ingredient]
Synonym: Gold, Radio-Colloidal
Synonym: Radio Colloidal Gold
Synonym: Radio-Colloidal Gold
Synonym: Radioactive Gold Colloid
Tree Number: T6.1.26.3.1
database_cross_reference: MSH:D006048
database_cross_reference: NDFRT:N0000166160

Hafnium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00005910
PMOID: PMO:00015389
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: HAFNIUM
Synonym: Hafnium (substance)
Synonym: Hafnium [Chemical/Ingredient]
Synonym: Hafnium, NOS
Synonym: Hf
Synonym: hafnium
Tree Number: T6.1.10.6.20
Tree Number: T6.1.6.12.20
Tree Number: T6.1.6.14.6
database_cross_reference: AOD:0000019517
database_cross_reference: LCH:U002064
database_cross_reference: LCH_NW:sh85058238
database_cross_reference: MSH:D006195
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:X71938L1DO
database_cross_reference: NCI:C99317
database_cross_reference: NCI_FDA:X71938L1DO
database_cross_reference: NDFRT:N0000166251
database_cross_reference: RXNORM:1534767
database_cross_reference: SNMI:C-14700
database_cross_reference: SNOMEDCT_US:50672002

Indium
type: Class
subclass of: Metals, Heavy
MCID: MC00006802
PMOID: PMO:00015390
Subclass_of: Metals, Heavy
Synonym: INDIUM
Synonym: In
Synonym: In element
Synonym: Indium (substance)
Synonym: Indium [Chemical/Ingredient]
Synonym: Indium, NOS
Synonym: in
Synonym: indium
Tree Number: T6.1.10.6.21
Tree Number: T6.1.6.12.21
database_cross_reference: AOD:0000019471
database_cross_reference: CHV:0000006663
database_cross_reference: CSP:1852-8319
database_cross_reference: DRUGBANK:DB11659
database_cross_reference: LCH:U002408
database_cross_reference: LCH_NW:sh85065672
database_cross_reference: LNC:LP16824-2
database_cross_reference: LNC:MTHU022378
database_cross_reference: MSH:D007204
database_cross_reference: MTH:U002006
database_cross_reference: MTHSPL:045A6V3VFX
database_cross_reference: NCI:C66827
database_cross_reference: NCI_FDA:045A6V3VFX
database_cross_reference: NDFRT:N0000166265
database_cross_reference: RXNORM:1362699
database_cross_reference: SNMI:C-14500
database_cross_reference: SNOMEDCT_US:14401009

Iridium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00007041
PMOID: PMO:00015391
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: IRIDIUM
Synonym: Ir
Synonym: Ir element
Synonym: Iridium (substance)
Synonym: Iridium Metallicum
Synonym: Iridium [Chemical/Ingredient]
Synonym: Iridium, NOS
Synonym: iridium
Tree Number: T6.1.10.6.22
Tree Number: T6.1.6.12.22
Tree Number: T6.1.6.14.7
database_cross_reference: AOD:0000019522
database_cross_reference: CHV:0000006920
database_cross_reference: CSP:2544-4705
database_cross_reference: LCH:U002510
database_cross_reference: LCH_NW:sh85068067
database_cross_reference: MSH:D007495
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:44448S9773
database_cross_reference: NCI:C95183
database_cross_reference: NCI_FDA:44448S9773
database_cross_reference: NDFRT:N0000166270
database_cross_reference: RXNORM:1311131
database_cross_reference: SNMI:C-15100
database_cross_reference: SNOMEDCT_US:32926003

Iron
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00106392
PMOID: PMO:00015392
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Actyform
Synonym: Alsimine W Vitamins A D
Synonym: Appedrine
Synonym: Ascofer Cap 275mg
Synonym: Aurovela 24 Fe
Synonym: Aurovela Fe 1/20
Synonym: Bev 29 Tab
Synonym: BioFerr 90
Synonym: Bugs Bunny Chew Multi Vit Plus Iron
Synonym: C-Nate DHA
Tree Number: T6.1.10.6.23
Tree Number: T6.1.6.12.23
Tree Number: T6.1.6.14.8
database_cross_reference: AOD:0000001943
database_cross_reference: AOD:0000028719
database_cross_reference: CCPSS:1007469
database_cross_reference: CHV:0000006926
database_cross_reference: CHV:0000027969
database_cross_reference: CSP:1629-5100
database_cross_reference: DRUGBANK:DB01592
database_cross_reference: LCH:U002512
database_cross_reference: LCH_NW:sh85068131
database_cross_reference: LNC:LP15677-5
database_cross_reference: LNC:MTHU004837
database_cross_reference: MEDCIN:41222
database_cross_reference: MEDLINEPLUS:5542
database_cross_reference: MMSL:6958
database_cross_reference: MMSL:7441
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D007501
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:E1UOL152H7
database_cross_reference: NCI:C598
database_cross_reference: NCI_DCP:01419
database_cross_reference: NCI_FDA:E1UOL152H7
database_cross_reference: NCI_NCI-GLOSS:CDR0000446805
database_cross_reference: NDDF:000828
database_cross_reference: NDFRT:N0000006237
database_cross_reference: NDFRT:N0000146032
database_cross_reference: PDQ:CDR0000042183
database_cross_reference: PSY:26640
database_cross_reference: RCD:X795v
database_cross_reference: RCD:i1z..
database_cross_reference: RXNORM:90176
database_cross_reference: SNM:E-8473
database_cross_reference: SNM:F-10360
database_cross_reference: SNMI:C-13000
database_cross_reference: SNMI:C-A6210
database_cross_reference: SNOMEDCT_US:30729008
database_cross_reference: SNOMEDCT_US:350552003
database_cross_reference: SNOMEDCT_US:373755001
database_cross_reference: SNOMEDCT_US:3829006
database_cross_reference: VANDF:4017653

Iron Isotopes
type: Class
subclass of: Isotopes
MCID: MC00007049
PMOID: PMO:00015393
Subclass_of: Isotopes
Synonym: Iron Isotopes [Chemical/Ingredient]
Synonym: Iron isotope
Synonym: Iron isotope (substance)
Synonym: Iron--Isotopes
Synonym: Isotopes, Iron
Tree Number: T6.1.9.11
database_cross_reference: LCH_NW:sh85068140
database_cross_reference: MSH:D007503
database_cross_reference: NDFRT:N0000166107
database_cross_reference: SNMI:C-13001
database_cross_reference: SNOMEDCT_US:90567005

Iron Radioisotopes
type: Class
subclass of: Iron Isotopes
subclass of: Radioisotopes
MCID: MC00007050
PMOID: PMO:00015394
Subclass_of: Iron Isotopes
Subclass_of: Radioisotopes
Synonym: Iron Radioisotopes [Chemical/Ingredient]
Synonym: Iron radioisotope
Synonym: Iron radioisotope (substance)
Synonym: Iron radioisotope, NOS
Synonym: Radioisotopes, Iron
Tree Number: T6.1.9.11.1
Tree Number: T6.1.9.17.18
database_cross_reference: MSH:D007504
database_cross_reference: NDFRT:N0000166108
database_cross_reference: SNM:E-5168
database_cross_reference: SNMI:C-130A0
database_cross_reference: SNOMEDCT_US:69770009

Lead
type: Class
subclass of: Metals, Heavy
MCID: MC00007407
PMOID: PMO:00015395
Subclass_of: Metals, Heavy
Synonym: ???lead
Synonym: LEAD
Synonym: Lead (Metal)
Synonym: Lead (substance)
Synonym: Lead Metal
Synonym: Lead [Chemical/Ingredient]
Synonym: Lead analyte
Synonym: Lead analyte (substance)
Synonym: Lead, NOS
Synonym: Metallic Lead
Tree Number: T6.1.10.6.25
Tree Number: T6.1.6.12.25
database_cross_reference: AOD:0000019477
database_cross_reference: AOD:0000028716
database_cross_reference: CHV:0000007256
database_cross_reference: CSP:1852-8386
database_cross_reference: LCH:U002637
database_cross_reference: LCH_NW:sh85075435
database_cross_reference: LNC:LP14259-3
database_cross_reference: LNC:MTHU001584
database_cross_reference: LNC:MTHU022407
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D007854
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U002035
database_cross_reference: MTHSPL:2P299V784P
database_cross_reference: NCI:C44396
database_cross_reference: NCI_FDA:2P299V784P
database_cross_reference: NDDF:006305
database_cross_reference: NDFRT:N0000007826
database_cross_reference: PSY:27910
database_cross_reference: RCD:X79A9
database_cross_reference: RCD:Xa4kA
database_cross_reference: RXNORM:6260
database_cross_reference: SNM:F-10370
database_cross_reference: SNMI:C-13200
database_cross_reference: SNOMEDCT_US:290129001
database_cross_reference: SNOMEDCT_US:88488004

Manganese
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00007884
PMOID: PMO:00015396
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: 4 Trace Elements Injection, USP
Synonym: A.R.T.H. Away Formula
Synonym: Acti-MN + B1 + C Caplet
Synonym: Adrenergy Tablets
Synonym: Advanced 2000 Capsules
Synonym: Alphaligo
Synonym: Armax
Synonym: B & J Formula Dietary Supplement
Synonym: Bio-plex Tab 0.95mg
Synonym: C.H.V. Formula
Tree Number: T6.1.10.6.26
Tree Number: T6.1.6.12.26
Tree Number: T6.1.6.14.11
database_cross_reference: AOD:0000019505
database_cross_reference: AOD:0000028718
database_cross_reference: CHV:0000007724
database_cross_reference: CSP:1852-8510
database_cross_reference: DRUGBANK:DB06757
database_cross_reference: LCH:U002807
database_cross_reference: LCH_NW:sh85080479
database_cross_reference: LNC:LP16827-5
database_cross_reference: LNC:MTHU004292
database_cross_reference: MEDCIN:199599
database_cross_reference: MMSL:7425
database_cross_reference: MSH:D008345
database_cross_reference: MTH:U002061
database_cross_reference: MTHSPL:42Z2K6ZL8P
database_cross_reference: NCI:C624
database_cross_reference: NCI_DCP:01874
database_cross_reference: NDDF:000856
database_cross_reference: NDFRT:N0000007194
database_cross_reference: NDFRT:N0000146073
database_cross_reference: RCD:X79AB
database_cross_reference: RXNORM:6623
database_cross_reference: SNM:F-10410
database_cross_reference: SNMI:C-14900
database_cross_reference: SNOMEDCT_US:421451000
database_cross_reference: SNOMEDCT_US:87869004
database_cross_reference: USPMG:MTHU001749
database_cross_reference: VANDF:4017703

Mercury
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00008091
PMOID: PMO:00015397
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Hg
Synonym: Hg - Mercury
Synonym: Hg element
Synonym: Hydrargyrum
Synonym: Liquid Silver
Synonym: MERCURY
Synonym: Mercury (Metal)
Synonym: Mercury (substance)
Synonym: Mercury [Chemical/Ingredient]
Synonym: Mercury, NOS
Tree Number: T6.1.10.6.28
Tree Number: T6.1.6.12.28
Tree Number: T6.1.6.14.12
database_cross_reference: AOD:0000019466
database_cross_reference: CHV:0000007978
database_cross_reference: CSP:1852-8644
database_cross_reference: LCH:U002913
database_cross_reference: LCH_NW:sh85083794
database_cross_reference: LNC:LP14344-3
database_cross_reference: LNC:MTHU002897
database_cross_reference: MEDLINEPLUS:1436
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D008628
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:FXS1BY2PGL
database_cross_reference: NCI:C66842
database_cross_reference: NCI_FDA:FXS1BY2PGL
database_cross_reference: NCI_NCI-GLOSS:CDR0000285976
database_cross_reference: NDDF:003130
database_cross_reference: NDFRT:N0000166254
database_cross_reference: NDFRT:N0000176083
database_cross_reference: PSY:30930
database_cross_reference: RCD:X7963
database_cross_reference: RXNORM:6769
database_cross_reference: SNM:F-10390
database_cross_reference: SNMI:C-13300
database_cross_reference: SNOMEDCT_US:45262002
database_cross_reference: VANDF:4025953

Mercury Isotopes
type: Class
subclass of: Isotopes
MCID: MC00008092
PMOID: PMO:00015398
Subclass_of: Isotopes
Synonym: Isotopes, Mercury
Synonym: Mercury Isotopes [Chemical/Ingredient]
Synonym: Mercury isotope
Synonym: Mercury isotope (substance)
Synonym: Mercury--Isotopes
Tree Number: T6.1.9.12
database_cross_reference: LCH_NW:sh85083797
database_cross_reference: MSH:D008629
database_cross_reference: NDFRT:N0000166119
database_cross_reference: SNMI:C-13301
database_cross_reference: SNOMEDCT_US:14195003

Mercury Radioisotopes
type: Class
subclass of: Mercury Isotopes
subclass of: Radioisotopes
MCID: MC00008093
PMOID: PMO:00015399
Subclass_of: Mercury Isotopes
Subclass_of: Radioisotopes
Synonym: Mercury Radioisotopes [Chemical/Ingredient]
Synonym: Mercury radioisotope
Synonym: Mercury radioisotope (substance)
Synonym: Mercury radioisotope, NOS
Synonym: Radioisotopes, Mercury
Tree Number: T6.1.9.12.1
Tree Number: T6.1.9.17.21
database_cross_reference: MSH:D008631
database_cross_reference: NDFRT:N0000166120
database_cross_reference: SNM:E-5184
database_cross_reference: SNMI:C-133A0
database_cross_reference: SNOMEDCT_US:2441001

Molybdenum
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00008379
PMOID: PMO:00015400
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Formula Im-vitamins and Minerals Tab
Synonym: Iron 25mg With Vit B-cmplx, Vit C, Cu & Mo
Synonym: MOLYBDENUM
Synonym: Mineralex
Synonym: Mo
Synonym: Mo - Molybdenum
Synonym: Mo element
Synonym: Molybdenum (substance)
Synonym: Molybdenum [Chemical/Ingredient]
Synonym: Molybdenum, NOS
Tree Number: T6.1.10.6.29
Tree Number: T6.1.6.12.29
Tree Number: T6.1.6.14.13
database_cross_reference: AOD:0000019511
database_cross_reference: CHV:0000008220
database_cross_reference: CSP:1852-8711
database_cross_reference: DRUGBANK:DB11137
database_cross_reference: LCH:U003010
database_cross_reference: LCH_NW:sh85086637
database_cross_reference: LNC:LP16828-3
database_cross_reference: LNC:MTHU008687
database_cross_reference: MEDCIN:250033
database_cross_reference: MMSL:5128
database_cross_reference: MSH:D008982
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:81AH48963U
database_cross_reference: NCI:C666
database_cross_reference: NCI_DCP:01901
database_cross_reference: NCI_FDA:81AH48963U
database_cross_reference: NDDF:000865
database_cross_reference: NDFRT:N0000005881
database_cross_reference: NDFRT:N0000148158
database_cross_reference: PDQ:CDR0000038724
database_cross_reference: RCD:X80Ly
database_cross_reference: RXNORM:7024
database_cross_reference: SNM:F-10420
database_cross_reference: SNMI:C-15000
database_cross_reference: SNOMEDCT_US:71128006
database_cross_reference: VANDF:4020277

Nickel
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00008878
PMOID: PMO:00015401
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Metallic Nickel
Synonym: NICKEL
Synonym: Ni
Synonym: Ni - Nickel
Synonym: Ni element
Synonym: Nickel (substance)
Synonym: Nickel [Chemical/Ingredient]
Synonym: Nickel, NOS
Synonym: ni
Synonym: nickel
Tree Number: T6.1.10.6.31
Tree Number: T6.1.6.12.31
Tree Number: T6.1.6.14.14
database_cross_reference: AOD:0000019507
database_cross_reference: CHV:0000008704
database_cross_reference: CSP:1852-8778
database_cross_reference: LCH:U003229
database_cross_reference: LCH_NW:sh85091772
database_cross_reference: LNC:LP16829-1
database_cross_reference: LNC:MTHU003538
database_cross_reference: MSH:D009532
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7OV03QG267
database_cross_reference: NCI:C690
database_cross_reference: NCI_FDA:7OV03QG267
database_cross_reference: NDDF:006308
database_cross_reference: NDFRT:N0000006488
database_cross_reference: NDFRT:N0000022900
database_cross_reference: RCD:X79AE
database_cross_reference: RXNORM:1311629
database_cross_reference: SNM:F-10430
database_cross_reference: SNMI:C-13400
database_cross_reference: SNOMEDCT_US:33396006
database_cross_reference: VANDF:4020727

Niobium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00008909
PMOID: PMO:00015402
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: NIOBIUM
Synonym: Niobium [Chemical/Ingredient]
Synonym: niobium
Tree Number: T6.1.10.6.32
Tree Number: T6.1.6.12.32
Tree Number: T6.1.6.14.15
database_cross_reference: AOD:0000019510
database_cross_reference: CHV:0000008724
database_cross_reference: DRUGBANK:DB13031
database_cross_reference: LCH:U003235
database_cross_reference: LCH_NW:sh85091993
database_cross_reference: LNC:LP188755-5
database_cross_reference: LNC:MTHU049026
database_cross_reference: MSH:D009556
database_cross_reference: MTHSPL:05175J654G
database_cross_reference: NDFRT:N0000166256
database_cross_reference: RXNORM:1426867

Osmium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00009264
PMOID: PMO:00015403
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: OSMIUM
Synonym: Os
Synonym: Os - Osmium
Synonym: Os element
Synonym: Osmium (substance)
Synonym: Osmium Metallicum
Synonym: Osmium [Chemical/Ingredient]
Synonym: Osmium metallicum / osmium
Synonym: Osmium, NOS
Synonym: osmium
Tree Number: T6.1.10.6.34
Tree Number: T6.1.6.12.34
Tree Number: T6.1.6.14.16
database_cross_reference: ALT:HAOAR
database_cross_reference: AOD:0000019521
database_cross_reference: CHV:0000009059
database_cross_reference: CSP:1852-8831
database_cross_reference: LCH:U003397
database_cross_reference: LCH_NW:sh85095926
database_cross_reference: LNC:LP19176-4
database_cross_reference: LNC:MTHU006112
database_cross_reference: MSH:D009992
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2E7M255OPY
database_cross_reference: NCI:C95182
database_cross_reference: NCI_FDA:2E7M255OPY
database_cross_reference: NDFRT:N0000166267
database_cross_reference: RCD:X796R
database_cross_reference: RXNORM:1311130
database_cross_reference: SNMI:C-15200
database_cross_reference: SNOMEDCT_US:72578004

Palladium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00009638
PMOID: PMO:00015404
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: PALLADIUM
Synonym: Palladium (substance)
Synonym: Palladium Metallicum
Synonym: Palladium [Chemical/Ingredient]
Synonym: Palladium metallicum / palladium
Synonym: Palladium, NOS
Synonym: Pd
Synonym: Pd - Palladium
Synonym: Pd element
Synonym: palladium
Tree Number: T6.1.10.6.35
Tree Number: T6.1.6.12.35
Tree Number: T6.1.6.14.17
database_cross_reference: ALT:HAPAB
database_cross_reference: AOD:0000019515
database_cross_reference: CHV:0000009196
database_cross_reference: CSP:1852-8845
database_cross_reference: LCH:U003446
database_cross_reference: LCH_NW:sh85097207
database_cross_reference: LNC:LP65754-1
database_cross_reference: LNC:MTHU026991
database_cross_reference: MSH:D010165
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5TWQ1V240M
database_cross_reference: NCI:C95184
database_cross_reference: NCI_FDA:5TWQ1V240M
database_cross_reference: NDDF:016321
database_cross_reference: NDFRT:N0000166240
database_cross_reference: RCD:Xa4kD
database_cross_reference: RXNORM:1311279
database_cross_reference: SNMI:C-16000
database_cross_reference: SNOMEDCT_US:48714008

Platinum
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00010324
PMOID: PMO:00015405
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: PLATINUM
Synonym: Platinum (substance)
Synonym: Platinum Black
Synonym: Platinum [Chemical/Ingredient]
Synonym: Platinum, NOS
Synonym: Pt
Synonym: Pt - Platinum
Synonym: Pt element
Synonym: platinum
Synonym: platinum (Pt)
Tree Number: T6.1.10.6.36
Tree Number: T6.1.6.12.36
Tree Number: T6.1.6.14.18
database_cross_reference: AOD:0000019523
database_cross_reference: CHV:0000009840
database_cross_reference: CSP:1852-8912
database_cross_reference: DRUGBANK:DB12257
database_cross_reference: LCH:U003717
database_cross_reference: LCH_NW:sh85103305
database_cross_reference: LNC:LP14931-7
database_cross_reference: LNC:MTHU002192
database_cross_reference: MSH:D010984
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000086
database_cross_reference: MTHSPL:49DFR088MY
database_cross_reference: NCI:C376
database_cross_reference: NCI:C756
database_cross_reference: NCI_FDA:49DFR088MY
database_cross_reference: NCI_NCI-GLOSS:CDR0000045841
database_cross_reference: NDFRT:N0000166244
database_cross_reference: RCD:X79AG
database_cross_reference: RXNORM:1311280
database_cross_reference: SNMI:C-15300
database_cross_reference: SNOMEDCT_US:84847000

Rhenium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00011350
PMOID: PMO:00015406
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: RHENIUM
Synonym: Rhenium (substance)
Synonym: Rhenium [Chemical/Ingredient]
Synonym: rhenium
Tree Number: T6.1.10.6.40
Tree Number: T6.1.6.12.40
Tree Number: T6.1.6.14.19
database_cross_reference: AOD:0000019520
database_cross_reference: CHV:0000010839
database_cross_reference: LCH:U004116
database_cross_reference: LCH_NW:sh85113607
database_cross_reference: MSH:D012211
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7YHU292INY
database_cross_reference: NDFRT:N0000166247
database_cross_reference: RXNORM:1667763
database_cross_reference: SNOMEDCT_US:396000007

Rhodium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00011373
PMOID: PMO:00015407
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: RHODIUM
Synonym: Rh
Synonym: Rh element
Synonym: Rhodium (substance)
Synonym: Rhodium Metallicum
Synonym: Rhodium [Chemical/Ingredient]
Synonym: Rhodium metallicum / rhodium
Synonym: Rhodium, NOS
Synonym: rhodium
Synonym: rhodium metallicum/rhodium
Tree Number: T6.1.10.6.41
Tree Number: T6.1.6.12.41
Tree Number: T6.1.6.14.20
database_cross_reference: ALT:HARAR
database_cross_reference: AOD:0000019514
database_cross_reference: CSP:1852-8954
database_cross_reference: LCH:U004129
database_cross_reference: LCH_NW:sh85113755
database_cross_reference: MSH:D012238
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:DMK383DSAC
database_cross_reference: NCI:C95190
database_cross_reference: NCI_FDA:DMK383DSAC
database_cross_reference: NDFRT:N0000166250
database_cross_reference: RXNORM:1311402
database_cross_reference: SNMI:C-16700
database_cross_reference: SNOMEDCT_US:59801003

Ruthenium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00011529
PMOID: PMO:00015408
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: RUTHENIUM
Synonym: Ru element
Synonym: Ruthenium (substance)
Synonym: Ruthenium [Chemical/Ingredient]
Synonym: Ruthenium, NOS
Synonym: ruthenium
Tree Number: T6.1.10.6.43
Tree Number: T6.1.6.12.43
Tree Number: T6.1.6.14.21
database_cross_reference: AOD:0000019513
database_cross_reference: CHV:0000010977
database_cross_reference: CSP:1852-8967
database_cross_reference: LCH:U004178
database_cross_reference: LCH_NW:sh85116086
database_cross_reference: MSH:D012428
database_cross_reference: MTHSPL:7UI0TKC3U5
database_cross_reference: NDFRT:N0000166261
database_cross_reference: RXNORM:1534768
database_cross_reference: SNMI:C-18000
database_cross_reference: SNOMEDCT_US:7446004

Silver
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00011871
PMOID: PMO:00015409
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Ag
Synonym: Ag - Silver
Synonym: Ag element
Synonym: SILVER
Synonym: Silver (substance)
Synonym: Silver [Chemical/Ingredient]
Synonym: Silver, NOS
Synonym: silver
Synonym: silvers
Tree Number: T6.1.10.6.44
Tree Number: T6.1.6.12.44
Tree Number: T6.1.6.14.23
database_cross_reference: AOD:0000016815
database_cross_reference: ATC:D08AL30
database_cross_reference: CHV:0000011351
database_cross_reference: CSP:1852-8979
database_cross_reference: DRUGBANK:DB12965
database_cross_reference: LCH:U004321
database_cross_reference: LCH_NW:sh85122588
database_cross_reference: LNC:LP15141-2
database_cross_reference: LNC:MTHU007668
database_cross_reference: MSH:D012834
database_cross_reference: MTH:U002243
database_cross_reference: NCI:C84590
database_cross_reference: NCI_FDA:3M4G523W1G
database_cross_reference: NDFRT:N0000010175
database_cross_reference: RCD:Xa0vO
database_cross_reference: SNM:E-5205
database_cross_reference: SNM:F-10570
database_cross_reference: SNMI:C-13700
database_cross_reference: SNOMEDCT_US:41967008

Tantalum
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00012553
PMOID: PMO:00015410
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: TANTALUM
Synonym: Ta element
Synonym: Tantalum (substance)
Synonym: Tantalum [Chemical/Ingredient]
Synonym: Tantalum, NOS
Synonym: tantalum
Tree Number: T6.1.10.6.46
Tree Number: T6.1.6.12.46
Tree Number: T6.1.6.14.24
database_cross_reference: AOD:0000019518
database_cross_reference: CHV:0000012032
database_cross_reference: CSP:1852-9028
database_cross_reference: DRUGBANK:DB12859
database_cross_reference: LCH:U004580
database_cross_reference: LCH_NW:sh85132346
database_cross_reference: MSH:D013635
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:6424HBN274
database_cross_reference: NDFRT:N0000166275
database_cross_reference: RXNORM:1311490
database_cross_reference: SNMI:C-15600
database_cross_reference: SNOMEDCT_US:45215009

Thallium
type: Class
subclass of: Metals, Heavy
MCID: MC00012685
PMOID: PMO:00015411
Subclass_of: Metals, Heavy
Synonym: THALLIUM
Synonym: Th
Synonym: Thallium (substance)
Synonym: Thallium Metallicum
Synonym: Thallium [Chemical/Ingredient]
Synonym: Thallium metallicum / thallium
Synonym: Thallium, NOS
Synonym: Tl
Synonym: Tl - Thallium
Synonym: Tl element
Tree Number: T6.1.10.6.48
Tree Number: T6.1.6.12.48
database_cross_reference: ALT:HATAR
database_cross_reference: AOD:0000019472
database_cross_reference: AOD:0000028714
database_cross_reference: CHV:0000012149
database_cross_reference: CSP:1852-9046
database_cross_reference: LCH:U004640
database_cross_reference: LCH_NW:sh85134473
database_cross_reference: LNC:LP16837-4
database_cross_reference: LNC:MTHU005398
database_cross_reference: MSH:D013793
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:AD84R52XLF
database_cross_reference: NCI:C95188
database_cross_reference: NCI_FDA:AD84R52XLF
database_cross_reference: NDFRT:N0000007969
database_cross_reference: RCD:XC0RO
database_cross_reference: RXNORM:1311633
database_cross_reference: SNMI:C-13800
database_cross_reference: SNOMEDCT_US:71763007

Tin
type: Class
subclass of: Metals, Heavy
MCID: MC00012867
PMOID: PMO:00015412
Subclass_of: Metals, Heavy
Synonym: C.I. 77860
Synonym: Sn
Synonym: Sn - Tin
Synonym: Sn element
Synonym: Stannum
Synonym: Stannum metallicum / tin
Synonym: TIN
Synonym: Tin (substance)
Synonym: Tin Element
Synonym: Tin [Chemical/Ingredient]
Tree Number: T6.1.10.6.50
Tree Number: T6.1.6.12.50
database_cross_reference: ALT:HASDE
database_cross_reference: AOD:0000019476
database_cross_reference: AOD:0000028715
database_cross_reference: CHV:0000012298
database_cross_reference: CSP:1852-9088
database_cross_reference: LCH:U004701
database_cross_reference: LCH_NW:sh85135484
database_cross_reference: LNC:LP16838-2
database_cross_reference: LNC:MTHU003504
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D014001
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:387GMG9FH5
database_cross_reference: NCI:C76209
database_cross_reference: NCI_FDA:387GMG9FH5
database_cross_reference: NDDF:000859
database_cross_reference: NDFRT:N0000005778
database_cross_reference: NDFRT:N0000147401
database_cross_reference: RCD:X79GK
database_cross_reference: RXNORM:10603
database_cross_reference: SNM:F-10620
database_cross_reference: SNMI:C-13900
database_cross_reference: SNOMEDCT_US:12597001
database_cross_reference: VANDF:4019156

Tungsten
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00013235
PMOID: PMO:00015413
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: TUNGSTEN
Synonym: Tungsten (substance)
Synonym: Tungsten [Chemical/Ingredient]
Synonym: Tungsten, NOS
Synonym: W element
Synonym: Wolfram
Synonym: tungsten
Synonym: wolfram
Tree Number: T6.1.10.6.51
Tree Number: T6.1.6.12.51
Tree Number: T6.1.6.14.27
database_cross_reference: AOD:0000019519
database_cross_reference: CHV:0000012662
database_cross_reference: CSP:1852-9146
database_cross_reference: LCH:U004816
database_cross_reference: LCH_NW:sh85138607
database_cross_reference: LNC:LP18123-7
database_cross_reference: LNC:MTHU003430
database_cross_reference: MSH:D014414
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:V9306CXO6G
database_cross_reference: NDFRT:N0000166257
database_cross_reference: RXNORM:1667702
database_cross_reference: SNM:E-5279
database_cross_reference: SNMI:C-16400
database_cross_reference: SNOMEDCT_US:26194003

Vanadium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00013470
PMOID: PMO:00015414
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: V - Vanadium
Synonym: V element
Synonym: VANADIUM
Synonym: Vanadium (substance)
Synonym: Vanadium [Chemical/Ingredient]
Synonym: Vanadium, NOS
Synonym: mineral supplements vanadium
Synonym: vanadium
Synonym: vanadium (V)
Synonym: vanadium (medication)
Tree Number: T6.1.10.6.53
Tree Number: T6.1.6.12.53
Tree Number: T6.1.6.14.28
database_cross_reference: AOD:0000019503
database_cross_reference: CHV:0000012890
database_cross_reference: CSP:1852-9180
database_cross_reference: LCH:U004894
database_cross_reference: LCH_NW:sh85142005
database_cross_reference: LNC:LP16842-4
database_cross_reference: LNC:MTHU014134
database_cross_reference: MEDCIN:250042
database_cross_reference: MSH:D014639
database_cross_reference: MTH:U002346
database_cross_reference: MTHSPL:00J9J9XKDE
database_cross_reference: NCI_FDA:00J9J9XKDE
database_cross_reference: NDDF:006802
database_cross_reference: NDFRT:N0000006262
database_cross_reference: NDFRT:N0000148327
database_cross_reference: RCD:X79AJ
database_cross_reference: RXNORM:11121
database_cross_reference: SNMI:C-16500
database_cross_reference: SNOMEDCT_US:18925001
database_cross_reference: VANDF:4020799

Zinc
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00013807
PMOID: PMO:00015415
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: 30Zn
Synonym: 4 Trace Elements Injection, USP
Synonym: A + Zinc
Synonym: A.B.C. Formula #1
Synonym: A.R.T.H. Away Formula
Synonym: Acetabolan III Vitamin and Mineral Supplement
Synonym: Acetabolan-II Vitamin and Mineral Supplement
Synonym: Acti-ZN 25 Caplet
Synonym: Acti-cal/mag 2:1 + Zinc and D Caplet
Synonym: Acti-carotene + Zn Caplet
Tree Number: T6.1.10.6.54
Tree Number: T6.1.6.12.54
Tree Number: T6.1.6.14.30
database_cross_reference: AOD:0000019463
database_cross_reference: AOD:0000028713
database_cross_reference: CHV:0000013277
database_cross_reference: CSP:1852-9247
database_cross_reference: DRUGBANK:DB01593
database_cross_reference: LCH:U005086
database_cross_reference: LCH_NW:sh85149842
database_cross_reference: LNC:LP14795-6
database_cross_reference: LNC:MTHU001006
database_cross_reference: MEDCIN:41246
database_cross_reference: MMSL:207818
database_cross_reference: MMSL:5705
database_cross_reference: MSH:D015032
database_cross_reference: MTH:U002369
database_cross_reference: MTHSPL:J41CSQ7QDS
database_cross_reference: NCI:C948
database_cross_reference: NCI_DCP:00268
database_cross_reference: NCI_FDA:J41CSQ7QDS
database_cross_reference: NDDF:000841
database_cross_reference: NDDF:001941
database_cross_reference: NDFRT:N0000006869
database_cross_reference: NDFRT:N0000146033
database_cross_reference: PSY:57375
database_cross_reference: RCD:X79AK
database_cross_reference: RCD:x01QB
database_cross_reference: RXNORM:11416
database_cross_reference: SNM:E-8049
database_cross_reference: SNM:F-10650
database_cross_reference: SNMI:C-14100
database_cross_reference: SNMI:C-93050
database_cross_reference: SNOMEDCT_US:350591008
database_cross_reference: SNOMEDCT_US:387254007
database_cross_reference: SNOMEDCT_US:46856009
database_cross_reference: SNOMEDCT_US:86739005
database_cross_reference: VANDF:4017654

Zinc Isotopes
type: Class
subclass of: Isotopes
MCID: MC00013812
PMOID: PMO:00015416
Subclass_of: Isotopes
Synonym: Isotopes, Zinc
Synonym: Zinc Isotopes [Chemical/Ingredient]
Synonym: Zinc isotope
Synonym: Zinc isotope (substance)
Synonym: Zinc--Isotopes
Tree Number: T6.1.9.23
database_cross_reference: LCH_NW:sh85149846
database_cross_reference: MSH:D015033
database_cross_reference: NDFRT:N0000166137
database_cross_reference: SNMI:C-14101
database_cross_reference: SNOMEDCT_US:53560004

Zinc Radioisotopes
type: Class
subclass of: Zinc Isotopes
subclass of: Radioisotopes
MCID: MC00013820
PMOID: PMO:00015417
Subclass_of: Radioisotopes
Subclass_of: Zinc Isotopes
Synonym: Radioisotopes, Zinc
Synonym: Zinc Radioisotopes [Chemical/Ingredient]
Synonym: Zinc radioisotope
Synonym: Zinc radioisotope (substance)
Synonym: Zinc radioisotope, NOS
Tree Number: T6.1.9.17.38
Tree Number: T6.1.9.23.1
database_cross_reference: MSH:D015037
database_cross_reference: NDFRT:N0000166138
database_cross_reference: SNM:E-5213
database_cross_reference: SNMI:C-141A0
database_cross_reference: SNOMEDCT_US:57273000

Zirconium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
MCID: MC00013825
PMOID: PMO:00015418
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: ZIRCONIUM
Synonym: Zirconium (substance)
Synonym: Zirconium [Chemical/Ingredient]
Synonym: Zirconium, NOS
Synonym: Zr - Zirconium
Synonym: Zr element
Synonym: zirconium
Tree Number: T6.1.10.6.55
Tree Number: T6.1.6.12.55
Tree Number: T6.1.6.14.31
database_cross_reference: AOD:0000019509
database_cross_reference: CHV:0000013280
database_cross_reference: CSP:1853-1500
database_cross_reference: LCH:U005087
database_cross_reference: LCH_NW:sh85149899
database_cross_reference: LNC:LP17263-2
database_cross_reference: LNC:MTHU012984
database_cross_reference: MSH:D015040
database_cross_reference: MTHSPL:C6V6S92N3C
database_cross_reference: NDFRT:N0000166241
database_cross_reference: RCD:X79AL
database_cross_reference: RXNORM:1534771
database_cross_reference: SNMI:C-16800
database_cross_reference: SNOMEDCT_US:17678002

Metals, Light
type: Class
subclass of: Elements
subclass of: Metals
MCID: MC00133408
PMOID: PMO:00015419
Subclass_of: Elements
Subclass_of: Metals
Synonym: Light Metals
Synonym: Light metal
Synonym: Light metal (substance)
Synonym: Light metal, NOS
Synonym: Light metals
Synonym: Metals, Light [Chemical/Ingredient]
Tree Number: T6.1.10.7
Tree Number: T6.1.6.13
database_cross_reference: LCH_NW:sh85076899
database_cross_reference: MSH:D019565
database_cross_reference: NDFRT:N0000008004
database_cross_reference: SNMI:C-11830
database_cross_reference: SNOMEDCT_US:65436002

Aluminum
type: Class
subclass of: Metals, Light
MCID: MC00000679
PMOID: PMO:00015420
Subclass_of: Metals, Light
Synonym: 13Al
Synonym: AL
Synonym: ALUMINUM
Synonym: Al
Synonym: Al - Aluminium
Synonym: Al - Aluminum
Synonym: Al element
Synonym: Aluminio
Synonym: Aluminium
Synonym: Aluminium atom
Tree Number: T6.1.10.7.1
Tree Number: T6.1.6.13.1
database_cross_reference: AOD:0000019469
database_cross_reference: CHV:0000000955
database_cross_reference: CSP:1852-6873
database_cross_reference: DRUGBANK:DB00518
database_cross_reference: DRUGBANK:DB01370
database_cross_reference: LCH:U000169
database_cross_reference: LCH_NW:sh85003956
database_cross_reference: LNC:LP16800-2
database_cross_reference: LNC:MTHU004906
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000535
database_cross_reference: MTH:U001677
database_cross_reference: MTHSPL:CPD4NFA903
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C93162
database_cross_reference: NCI_FDA:CPD4NFA903
database_cross_reference: NCI_NCI-GLOSS:CDR0000639941
database_cross_reference: NDDF:001931
database_cross_reference: NDFRT:N0000166276
database_cross_reference: PSY:01930
database_cross_reference: RCD:X79HT
database_cross_reference: RCD:XaCwN
database_cross_reference: RCDAE:X79HT
database_cross_reference: RCDAE:XaCwN
database_cross_reference: RXNORM:1311504
database_cross_reference: SNM:F-10050
database_cross_reference: SNMI:C-12000
database_cross_reference: SNOMEDCT_US:12503006
database_cross_reference: SNOMEDCT_US:255977005

Titanium
type: Class
subclass of: Metals, Light
subclass of: Transition Elements
MCID: MC00012887
PMOID: PMO:00015421
Subclass_of: Metals, Light
Subclass_of: Transition Elements
Synonym: TITANIUM
Synonym: Ti
Synonym: Ti - Titanium
Synonym: Ti element
Synonym: Titanium (substance)
Synonym: Titanium Metallicum
Synonym: Titanium [Chemical/Ingredient]
Synonym: Titanium metallicum / titanium
Synonym: Titanium, NOS
Synonym: titanium
Tree Number: T6.1.10.7.7
Tree Number: T6.1.6.13.7
Tree Number: T6.1.6.14.26
database_cross_reference: ALT:HATBG
database_cross_reference: AOD:0000019502
database_cross_reference: CHV:0000012322
database_cross_reference: CSP:1852-9113
database_cross_reference: LCH:U004707
database_cross_reference: LCH_NW:sh85135605
database_cross_reference: LNC:LP16839-0
database_cross_reference: LNC:MTHU014132
database_cross_reference: MSH:D014025
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:D1JT611TNE
database_cross_reference: NCI:C95189
database_cross_reference: NCI_FDA:D1JT611TNE
database_cross_reference: NDDF:001910
database_cross_reference: NDFRT:N0000007879
database_cross_reference: RCD:X79AI
database_cross_reference: RXNORM:1305547
database_cross_reference: SNMI:C-16600
database_cross_reference: SNOMEDCT_US:1166006

Transition Elements
type: Class
subclass of: Elements
MCID: MC00224116
PMOID: PMO:00015422
Subclass_of: Elements
Synonym: Elements, Transition
Synonym: Transition Elements [Chemical/Ingredient]
Synonym: Transition metals
Synonym: transition elements
Synonym: transition metal
Tree Number: T6.1.6.14
database_cross_reference: AOD:0000019500
database_cross_reference: CSP:1852-7783
database_cross_reference: LCH_NW:sh85136954
database_cross_reference: MSH:D028561
database_cross_reference: NDFRT:N0000011255

Metalloids
type: Class
subclass of: Elements
MCID: MC00146749
PMOID: PMO:00015423
Subclass_of: Elements
Synonym: Intermediate Metals
Synonym: Metalloids (substance)
Synonym: Metalloids [Chemical/Ingredient]
Synonym: Metals, Intermediate
Synonym: Semi Metals
Synonym: Semi-Metals
Tree Number: T6.1.6.15
database_cross_reference: MSH:D058955
database_cross_reference: NDFRT:N0000182063
database_cross_reference: RCD:XM0Eb
database_cross_reference: SNOMEDCT_US:272154003

Arsenic
type: Class
subclass of: Metalloids
MCID: MC00001245
PMOID: PMO:00015424
Subclass_of: Metalloids
Synonym: ARSENIC
Synonym: Arsenic (substance)
Synonym: Arsenic [Chemical/Ingredient]
Synonym: Arsenic product
Synonym: Arsenic product (product)
Synonym: Arsenic, NOS
Synonym: As
Synonym: As - Arsenic
Synonym: As element
Synonym: arsenic
Tree Number: T6.1.6.15.2
database_cross_reference: AOD:0000019479
database_cross_reference: CHV:0000001442
database_cross_reference: CSP:1852-9381
database_cross_reference: LCH:U000361
database_cross_reference: LCH_NW:sh85007449
database_cross_reference: LNC:LP16802-8
database_cross_reference: LNC:MTHU004556
database_cross_reference: MEDLINEPLUS:1569
database_cross_reference: MSH:D001151
database_cross_reference: MTH:U001715
database_cross_reference: MTHSPL:N712M78A8G
database_cross_reference: NCI:C28131
database_cross_reference: NCI_FDA:N712M78A8G
database_cross_reference: NCI_NCI-GLOSS:CDR0000044303
database_cross_reference: NDDF:003137
database_cross_reference: NDFRT:N0000022206
database_cross_reference: NDFRT:N0000166177
database_cross_reference: RCD:X794o
database_cross_reference: RXNORM:1111
database_cross_reference: SNM:F-10070
database_cross_reference: SNMI:C-11500
database_cross_reference: SNOMEDCT_US:413576005
database_cross_reference: SNOMEDCT_US:47809000
database_cross_reference: VANDF:4024201

Boron
type: Class
subclass of: Metalloids
MCID: MC00001890
PMOID: PMO:00015425
Subclass_of: Metalloids
Synonym: B
Synonym: B - Boron
Synonym: B element
Synonym: BORON
Synonym: Boron (substance)
Synonym: Boron [Chemical/Ingredient]
Synonym: Boron, NOS
Synonym: Calcium Folic Acid Plus D Chewable
Synonym: boron
Synonym: boron (medication)
Tree Number: T6.1.6.15.3
database_cross_reference: AOD:0000019467
database_cross_reference: CHV:0000002099
database_cross_reference: CSP:1852-7182
database_cross_reference: DRUGBANK:DB11203
database_cross_reference: LCH:U000653
database_cross_reference: LCH_NW:sh85015871
database_cross_reference: LNC:LP16808-5
database_cross_reference: LNC:MTHU014128
database_cross_reference: MEDCIN:250028
database_cross_reference: MMSL:7468
database_cross_reference: MSH:D001895
database_cross_reference: MTH:U001757
database_cross_reference: MTHSPL:N9E3X5056Q
database_cross_reference: NCI:C61481
database_cross_reference: NCI_FDA:N9E3X5056Q
database_cross_reference: NDDF:005179
database_cross_reference: NDFRT:N0000007066
database_cross_reference: NDFRT:N0000148267
database_cross_reference: RCD:Xa4kE
database_cross_reference: RXNORM:1705
database_cross_reference: SNM:F-10090
database_cross_reference: SNMI:C-10900
database_cross_reference: SNOMEDCT_US:70597009
database_cross_reference: VANDF:4020564

Silicon
type: Class
subclass of: Metalloids
MCID: MC00011861
PMOID: PMO:00015426
Subclass_of: Metalloids
Synonym: Actical Plus Calcium-magnesium-vitamin D3-silicon Chewable
Synonym: Active Calcium Plus Magnesium, Vitamin D and Silicon
Synonym: Calcium Complex High Grade
Synonym: Calcium Magnesium Sulfur Silicon - Tab
Synonym: Osteo Formula Tab
Synonym: Osteo Tablets
Synonym: Procosa II
Synonym: SILICON
Synonym: Si
Synonym: Si - Silicon
Tree Number: T6.1.6.15.6
database_cross_reference: AOD:0000019474
database_cross_reference: CHV:0000011344
database_cross_reference: CSP:2706-6723
database_cross_reference: DRUGBANK:DB12982
database_cross_reference: LCH:U004315
database_cross_reference: LCH_NW:sh85122512
database_cross_reference: LNC:LP14884-8
database_cross_reference: LNC:MTHU002106
database_cross_reference: MEDCIN:199521
database_cross_reference: MSH:D012825
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:Z4152N8IUI
database_cross_reference: NCI:C84589
database_cross_reference: NCI_FDA:Z4152N8IUI
database_cross_reference: NDDF:009771
database_cross_reference: NDFRT:N0000166172
database_cross_reference: RCD:X90Ek
database_cross_reference: RXNORM:9774
database_cross_reference: SNM:F-10550
database_cross_reference: SNMI:C-10940
database_cross_reference: SNOMEDCT_US:51420009

Free Radicals
type: Class
subclass of: Inorganic Chemicals
subclass of: Organic Chemicals
MCID: MC00005295
PMOID: PMO:00015427
Subclass_of: Inorganic Chemicals
Subclass_of: Organic Chemicals
Synonym: Free Radical
Synonym: Free Radicals [Chemical/Ingredient]
Synonym: Free radical
Synonym: Free radical (substance)
Synonym: Radicals, Free
Synonym: free radical
Synonym: free radical -Highly reactive chemicals
Synonym: free radicals
Tree Number: T6.1.7
Tree Number: T6.2.15
database_cross_reference: AOD:0000001288
database_cross_reference: CHV:0000005253
database_cross_reference: CSP:1010-1403
database_cross_reference: MSH:D005609
database_cross_reference: NCI:C512
database_cross_reference: NCI_NCI-GLOSS:CDR0000044030
database_cross_reference: NDFRT:N0000011364
database_cross_reference: RCD:Xa4gL
database_cross_reference: SNM:F-10040
database_cross_reference: SNMI:C-10023
database_cross_reference: SNOMEDCT_US:39265005

Nitric Oxide
type: Class
subclass of: Free Radicals
subclass of: Nitrogen Oxides
subclass of: Reactive Nitrogen Species
MCID: MC00008922
PMOID: PMO:00015428
Subclass_of: Free Radicals
Subclass_of: Nitrogen Oxides
Subclass_of: Reactive Nitrogen Species
Synonym: (.)NO
Synonym: (NO)(.)
Synonym: EDRF
Synonym: Endogenous Nitrate Vasodilator
Synonym: Endothelium-Derived Nitric Oxide
Synonym: Endothelium-Derived Relaxing Factor
Synonym: Kinox
Synonym: Mononitrogen Monoxide
Synonym: Mononitrogen monoxide
Synonym: Monoxide, Mononitrogen
Tree Number: T6.1.33.10.1
Tree Number: T6.1.33.6.1
Tree Number: T6.1.7.1
database_cross_reference: AOD:0000019613
database_cross_reference: ATC:R07AX01
database_cross_reference: CHV:0000008733
database_cross_reference: CSP:4000-0268
database_cross_reference: DRUGBANK:DB00435
database_cross_reference: LCH_NW:sh90001567
database_cross_reference: LNC:LP173640-6
database_cross_reference: LNC:MTHU047590
database_cross_reference: MEDCIN:258041
database_cross_reference: MMSL:17479
database_cross_reference: MMSL:d04508
database_cross_reference: MSH:D009569
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:31C4KY9ESH
database_cross_reference: NCI:C695
database_cross_reference: NCI_FDA:31C4KY9ESH
database_cross_reference: NDDF:012088
database_cross_reference: NDFRT:N0000006603
database_cross_reference: NDFRT:N0000148689
database_cross_reference: PSY:34068
database_cross_reference: RCD:X799J
database_cross_reference: RXNORM:7442
database_cross_reference: SNM:E-5075
database_cross_reference: SNMI:C-10712
database_cross_reference: SNOMEDCT_US:409378005
database_cross_reference: SNOMEDCT_US:6710000
database_cross_reference: VANDF:4021248

Reactive Oxygen Species
type: Class
subclass of: Free Radicals
subclass of: Oxygen Compounds
MCID: MC00063399
PMOID: PMO:00015429
Subclass_of: Free Radicals
Subclass_of: Oxygen Compounds
Synonym: Active Oxygen
Synonym: Active oxygen
Synonym: Oxygen Radical
Synonym: Oxygen Radicals
Synonym: Oxygen Species, Reactive
Synonym: Oxygen, Active
Synonym: Pro Oxidants
Synonym: Pro-Oxidants
Synonym: Pro-oxidant
Synonym: ROS
Tree Number: T6.1.18.2
Tree Number: T6.1.7.2
database_cross_reference: AOD:0000001290
database_cross_reference: CHV:0000017978
database_cross_reference: CSP:2191-6300
database_cross_reference: LCH:U006204
database_cross_reference: LCH_NW:sh85000738
database_cross_reference: MSH:D017382
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C1421
database_cross_reference: NCI:C93260
database_cross_reference: NCI_NCI-GLOSS:CDR0000372940
database_cross_reference: NDFRT:N0000166150

Singlet Oxygen
type: Class
subclass of: Reactive Oxygen Species
MCID: MC00037775
PMOID: PMO:00015430
Subclass_of: Reactive Oxygen Species
Synonym: Dioxygen, Singlet
Synonym: Oxygen, Singlet
Synonym: Singlet Dioxygen
Synonym: Singlet Oxygen [Chemical/Ingredient]
Synonym: Singlet oxygen
Synonym: Singlet oxygen (substance)
Synonym: singlet oxygen
Tree Number: T6.1.7.2.4
database_cross_reference: CHV:0000014814
database_cross_reference: CSP:2189-2569
database_cross_reference: MSH:D026082
database_cross_reference: NDFRT:N0000166151
database_cross_reference: SNMI:C-10113
database_cross_reference: SNOMEDCT_US:51776002

Gases
type: Class
subclass of: Inorganic Chemicals
MCID: MC00005443
PMOID: PMO:00015431
Subclass_of: Inorganic Chemicals
Synonym: Gas
Synonym: Gas, NOS
Synonym: Gaseous substance
Synonym: Gaseous substance (substance)
Synonym: Gases [Chemical/Ingredient]
Synonym: gas
Synonym: gases
Tree Number: T6.1.8
database_cross_reference: AOD:0000001129
database_cross_reference: CHV:0000005358
database_cross_reference: CSP:1244-3286
database_cross_reference: FMA:85816
database_cross_reference: LCH:U001918
database_cross_reference: LCH_NW:sh85053380
database_cross_reference: LNC:LP7253-0
database_cross_reference: LNC:MTHU009035
database_cross_reference: MSH:D005740
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45299
database_cross_reference: NDFRT:N0000007949
database_cross_reference: RCD:X799E
database_cross_reference: SNM:E-6600
database_cross_reference: SNM:U000147
database_cross_reference: SNMI:C-10080
database_cross_reference: SNOMEDCT_US:74947009

Greenhouse Gases
type: Class
subclass of: Gases
PMOID: PMO:00015432
Subclass_of: Gases
Tree Number: T6.1.8.1

Ammonia
type: Class
subclass of: Gases
subclass of: Nitrogen Compounds
MCID: MC00000786
PMOID: PMO:00015433
Subclass_of: Gases
Subclass_of: Nitrogen Compounds
Synonym: AMMONIA
Synonym: After Bite Liquid 3.61%
Synonym: After Bite Outdoor
Synonym: After Bite Xtra
Synonym: After Bite the Itch Eraser Xtra
Synonym: Ammonia (product)
Synonym: Ammonia (substance)
Synonym: Ammonia Pad
Synonym: Ammonia [Chemical/Ingredient]
Synonym: Ammonia, NOS
Tree Number: T6.1.33.1
Tree Number: T6.1.8.2
database_cross_reference: AOD:0000018367
database_cross_reference: CHV:0000001028
database_cross_reference: CSP:0155-6463
database_cross_reference: DRUGBANK:DB11118
database_cross_reference: LCH:U000204
database_cross_reference: LCH_NW:sh85004538
database_cross_reference: LNC:LP14071-2
database_cross_reference: LNC:MTHU005196
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000641
database_cross_reference: MTH:U001685
database_cross_reference: MTHSPL:5138Q19F1X
database_cross_reference: NCI:C76698
database_cross_reference: NCI_FDA:5138Q19F1X
database_cross_reference: NDDF:001386
database_cross_reference: NDFRT:N0000005783
database_cross_reference: NDFRT:N0000022607
database_cross_reference: RCD:X794Z
database_cross_reference: RXNORM:1299884
database_cross_reference: SNM:F-10060
database_cross_reference: SNMI:C-10750
database_cross_reference: SNOMEDCT_US:421024009
database_cross_reference: SNOMEDCT_US:43953005
database_cross_reference: VANDF:4019608

Carbon Dioxide
type: Class
subclass of: Oxides
subclass of: Gases
subclass of: Carbon Compounds, Inorganic
MCID: MC00002237
PMOID: PMO:00015434
Subclass_of: Carbon Compounds, Inorganic
Subclass_of: Gases
Subclass_of: Oxides
Synonym: Air 90% Carbon Dioxide 10%
Synonym: Anhydride, Carbonic
Synonym: CARBON DIOXIDE
Synonym: CO2
Synonym: CO2 - Carbon dioxide
Synonym: Carbon Dioxide 1% W Air
Synonym: Carbon Dioxide 1% W Oxygen
Synonym: Carbon Dioxide 12.1% W Oxygen
Synonym: Carbon Dioxide 15.1% W Air
Synonym: Carbon Dioxide 23.1% W Oxygen
Tree Number: T6.1.16.1
Tree Number: T6.1.18.1.2
Tree Number: T6.1.8.3
database_cross_reference: AOD:0000019628
database_cross_reference: AOD:0000028729
database_cross_reference: ATC:V03AN02
database_cross_reference: CHV:0000002393
database_cross_reference: CSP:2604-9089
database_cross_reference: DRUGBANK:DB09157
database_cross_reference: LCH:U000785
database_cross_reference: LCH_NW:sh85020108
database_cross_reference: LNC:LP15150-3
database_cross_reference: LNC:MTHU002535
database_cross_reference: MMSL:21415
database_cross_reference: MMSL:d06861
database_cross_reference: MSH:D002245
database_cross_reference: MTH:U000112
database_cross_reference: MTH:U000181
database_cross_reference: MTH:U000237
database_cross_reference: MTH:U001780
database_cross_reference: MTHSPL:142M471B3J
database_cross_reference: NCI:C65288
database_cross_reference: NCI_FDA:142M471B3J
database_cross_reference: NCI_NCI-GLOSS:CDR0000538147
database_cross_reference: NDDF:002516
database_cross_reference: NDFRT:N0000005729
database_cross_reference: NDFRT:N0000147376
database_cross_reference: PSY:07530
database_cross_reference: RCD:X799H
database_cross_reference: RXNORM:2034
database_cross_reference: SNM:E-5013
database_cross_reference: SNM:F-10170
database_cross_reference: SNMI:C-10520
database_cross_reference: SNOMEDCT_US:31811003
database_cross_reference: SNOMEDCT_US:421982008
database_cross_reference: VANDF:4019125

Carbon Monoxide
type: Class
subclass of: Oxides
subclass of: Gases
subclass of: Carbon Compounds, Inorganic
MCID: MC00002240
PMOID: PMO:00015435
Subclass_of: Carbon Compounds, Inorganic
Subclass_of: Gases
Subclass_of: Oxides
Synonym: CARBON MONOXIDE
Synonym: CO
Synonym: CO - Carbon monoxide
Synonym: Carbon Monox, Helium, Oxygen, Nitrogen L.D.M.
Synonym: Carbon Monoxide [Chemical/Ingredient]
Synonym: Carbon Monoxide, Compressed Air Medical G.M.
Synonym: Carbon monoxide
Synonym: Carbon monoxide (substance)
Synonym: Carbon monoxide gas
Synonym: Carboneum oxygenisatum
Tree Number: T6.1.16.3
Tree Number: T6.1.18.1.3
Tree Number: T6.1.8.4
database_cross_reference: AOD:0000019630
database_cross_reference: CHV:0000002395
database_cross_reference: CSP:0556-4683
database_cross_reference: DRUGBANK:DB11588
database_cross_reference: LCH:U000786
database_cross_reference: LCH_NW:sh85020121
database_cross_reference: MSH:D002248
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7U1EE4V452
database_cross_reference: NCI:C76742
database_cross_reference: NCI_FDA:7U1EE4V452
database_cross_reference: NCI_NCI-GLOSS:CDR0000496500
database_cross_reference: NDDF:003798
database_cross_reference: NDFRT:N0000005737
database_cross_reference: NDFRT:N0000147407
database_cross_reference: PSY:07540
database_cross_reference: RCD:X8070
database_cross_reference: RXNORM:2037
database_cross_reference: SNM:E-5053
database_cross_reference: SNMI:C-10526
database_cross_reference: SNOMEDCT_US:51765001
database_cross_reference: VANDF:4019162

Nitrogen Oxides
type: Class
subclass of: Oxides
subclass of: Gases
subclass of: Nitrogen Compounds
MCID: MC00008941
PMOID: PMO:00015436
Subclass_of: Gases
Subclass_of: Nitrogen Compounds
Subclass_of: Oxides
Synonym: Nitrogen Oxides [Chemical/Ingredient]
Synonym: Nitrogen oxides
Synonym: Oxide of nitrogen
Synonym: Oxide of nitrogen (substance)
Synonym: Oxides, Nitrogen
Synonym: nitrogen oxide
Synonym: nitrogen oxides
Tree Number: T6.1.18.1.6
Tree Number: T6.1.33.6
Tree Number: T6.1.8.10
database_cross_reference: AOD:0000019610
database_cross_reference: CHV:0000008743
database_cross_reference: CSP:2078-6554
database_cross_reference: LCH:U003248
database_cross_reference: LCH_NW:sh85092082
database_cross_reference: MSH:D009589
database_cross_reference: MTH:U002111
database_cross_reference: NDFRT:N0000007660
database_cross_reference: RCD:XaD1X
database_cross_reference: SNOMEDCT_US:311735009

Nitrogen Dioxide
type: Class
subclass of: Nitrogen Oxides
MCID: MC00008938
PMOID: PMO:00015437
Subclass_of: Nitrogen Oxides
Synonym: Dioxide, Nitrogen
Synonym: NO2 - Nitrogen dioxide
Synonym: Nitrogen Dioxide [Chemical/Ingredient]
Synonym: Nitrogen Peroxide
Synonym: Nitrogen dioxide
Synonym: Nitrogen dioxide (substance)
Synonym: Nitrogen oxide (NO2)
Synonym: Nitrogen peroxide
Synonym: Nitrogen peroxide (substance)
Synonym: Peroxide, Nitrogen
Tree Number: T6.1.33.6.2
Tree Number: T6.1.8.10.1
database_cross_reference: AOD:0000019619
database_cross_reference: CHV:0000008741
database_cross_reference: LCH:U003247
database_cross_reference: LCH_NW:sh85092072
database_cross_reference: LNC:LP186951-2
database_cross_reference: LNC:MTHU052550
database_cross_reference: MSH:D009585
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C29843
database_cross_reference: NDFRT:N0000166161
database_cross_reference: RCD:X79Bq
database_cross_reference: SNM:E-5076
database_cross_reference: SNMI:C-10713
database_cross_reference: SNMI:C-10715
database_cross_reference: SNOMEDCT_US:23398000
database_cross_reference: SNOMEDCT_US:91424007

Nitrous Oxide
type: Class
subclass of: Nitrogen Oxides
MCID: MC00008964
PMOID: PMO:00015438
Subclass_of: Nitrogen Oxides
Synonym: Alnox Gas
Synonym: Dinitrogen Monoxide
Synonym: Dinitrogen monoxide
Synonym: Gas, Laughing
Synonym: Laughing Gas
Synonym: Laughing gas
Synonym: Liqui-med Analgesic Gas
Synonym: N2O - Nitrous oxide
Synonym: NITROUS OXIDE
Synonym: Nitrious oxide
Tree Number: T6.1.33.6.3
Tree Number: T6.1.8.10.2
database_cross_reference: AOD:0000019620
database_cross_reference: ATC:N01AX13
database_cross_reference: CHV:0000008748
database_cross_reference: CSP:2083-5252
database_cross_reference: DRUGBANK:DB06690
database_cross_reference: LCH:U003253
database_cross_reference: LCH_NW:sh85092097
database_cross_reference: LNC:LP100617-2
database_cross_reference: LNC:MTHU035878
database_cross_reference: MEDCIN:199095
database_cross_reference: MMSL:d00934
database_cross_reference: MSH:D009609
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:K50XQU1029
database_cross_reference: NCI:C73617
database_cross_reference: NCI_FDA:K50XQU1029
database_cross_reference: NDDF:001387
database_cross_reference: NDFRT:N0000007349
database_cross_reference: NDFRT:N0000147387
database_cross_reference: RCD:XM0ld
database_cross_reference: RCD:o26..
database_cross_reference: RXNORM:7486
database_cross_reference: SNM:E-7062
database_cross_reference: SNMI:C-6A118
database_cross_reference: SNOMEDCT_US:111132001
database_cross_reference: SNOMEDCT_US:273959001
database_cross_reference: SNOMEDCT_US:388185005
database_cross_reference: VANDF:4019137

Ozone
type: Class
subclass of: Oxygen
MCID: MC00009603
PMOID: PMO:00015439
Subclass_of: Oxygen
Synonym: O3
Synonym: O3 - Ozone
Synonym: O>3<
Synonym: Ozone (substance)
Synonym: Ozone [Chemical/Ingredient]
Synonym: ozone
Synonym: ozone (O3)
Tree Number: T6.1.8.11.2
database_cross_reference: CHV:0000009171
database_cross_reference: CSP:2189-1975
database_cross_reference: DRUGBANK:DB12510
database_cross_reference: LCH:U003434
database_cross_reference: LCH_NW:sh85096391
database_cross_reference: MEDLINEPLUS:1539
database_cross_reference: MSH:D010126
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166152
database_cross_reference: RCD:X796S
database_cross_reference: SNM:E-5041
database_cross_reference: SNMI:C-10114
database_cross_reference: SNOMEDCT_US:40057008

Sulfur Dioxide
type: Class
subclass of: Gases
subclass of: Sulfur Oxides
MCID: MC00012413
PMOID: PMO:00015441
Subclass_of: Gases
Subclass_of: Sulfur Oxides
Synonym: Anhydride, Sulfurous
Synonym: Dioxide, Sulfur
Synonym: SO2
Synonym: SULFUR DIOXIDE
Synonym: Sulfur Dioxide [Chemical/Ingredient]
Synonym: Sulfur dioxide
Synonym: Sulfur dioxide (substance)
Synonym: Sulfurous Anhydride
Synonym: Sulfurous anhydride
Synonym: Sulphur dioxide
Tree Number: T6.1.13.5.1
Tree Number: T6.1.8.12
database_cross_reference: ALT:HASEE
database_cross_reference: AOD:0000019642
database_cross_reference: AOD:0000028731
database_cross_reference: CHV:0000011877
database_cross_reference: LCH_NW:sh85130378
database_cross_reference: MSH:D013458
database_cross_reference: MTH:U002278
database_cross_reference: MTHSPL:0UZA3422Q4
database_cross_reference: NDDF:009284
database_cross_reference: NDFRT:N0000166209
database_cross_reference: RCD:X796u
database_cross_reference: RCDAE:X796u
database_cross_reference: RXNORM:1362879
database_cross_reference: SNM:E-5085
database_cross_reference: SNMI:C-10813
database_cross_reference: SNOMEDCT_US:86233005

Sulfur Hexafluoride
type: Class
subclass of: Gases
subclass of: Sulfur Compounds
MCID: MC00012414
PMOID: PMO:00015442
Subclass_of: Gases
Subclass_of: Sulfur Compounds
Synonym: Hexafluoride, Sulfur
Synonym: Hexafluorosulfur
Synonym: S6F
Synonym: SULFUR HEXAFLUORIDE
Synonym: Sulfur Hexafluoride [Chemical/Ingredient]
Synonym: Sulfur fluoride (SF6), (OC-6-11)-
Synonym: Sulfur hexafluoride
Synonym: Sulfur hexafluoride (product)
Synonym: Sulfur hexafluoride (substance)
Synonym: Sulphur Hexafluoride
Tree Number: T6.1.13.4
Tree Number: T6.1.8.13
database_cross_reference: ATC:V08DA05
database_cross_reference: CHV:0000011878
database_cross_reference: DRUGBANK:DB11104
database_cross_reference: LCH:U006203
database_cross_reference: LCH_NW:sh85130381
database_cross_reference: MMSL:22240
database_cross_reference: MMSL:d05887
database_cross_reference: MSH:D013459
database_cross_reference: MTHSPL:WS7LR3I1D6
database_cross_reference: NCI:C84187
database_cross_reference: NCI_FDA:WS7LR3I1D6
database_cross_reference: NDDF:010822
database_cross_reference: NDFRT:N0000166210
database_cross_reference: NDFRT:N0000192569
database_cross_reference: RCD:X80CT
database_cross_reference: RCDAE:X80CT
database_cross_reference: RXNORM:1599276
database_cross_reference: SNOMEDCT_US:259276004
database_cross_reference: SNOMEDCT_US:418601008
database_cross_reference: VANDF:4035805

Plasma Gases
type: Class
subclass of: Gases
MCID: MC00797941
PMOID: PMO:00015443
Subclass_of: Gases
Synonym: Gases, Plasma
Synonym: Plasma Gases [Chemical/Ingredient]
Tree Number: T6.1.8.14
database_cross_reference: MSH:D058626
database_cross_reference: NDFRT:N0000182120

Gasotransmitters
type: Class
subclass of: Gases
MCID: MC00943884
PMOID: PMO:00015444
Subclass_of: Gases
Synonym: Gaseous Mediators
Synonym: Gaseous Messenger Molecules
Synonym: Gaseous Secondary Messengers
Synonym: Gaseous Signal Transducers
Synonym: Gasotransmitters [Chemical/Ingredient]
Synonym: Mediators, Gaseous
Synonym: Messenger Molecules, Gaseous
Synonym: Messengers, Gaseous Secondary
Synonym: Molecules, Gaseous Messenger
Synonym: Secondary Messengers, Gaseous
Tree Number: T6.1.8.15
database_cross_reference: MSH:D064426
database_cross_reference: NDFRT:N0000189474

Isotopes
type: Class
subclass of: Inorganic Chemicals
MCID: MC00007119
PMOID: PMO:00015445
Subclass_of: Inorganic Chemicals
Synonym: ISOTOPE
Synonym: Isotope
Synonym: Isotope (substance)
Synonym: Isotope, NOS
Synonym: Isotopes [Chemical/Ingredient]
Synonym: isotope
Synonym: isotopes
Tree Number: T6.1.9
database_cross_reference: AOD:0000001492
database_cross_reference: CHV:0000006973
database_cross_reference: LCH:U002527
database_cross_reference: LCH_NW:sh85068681
database_cross_reference: MSH:D007554
database_cross_reference: NCI:C47933
database_cross_reference: NCI_FDA:C47933
database_cross_reference: NCI_NCI-GLOSS:CDR0000613515
database_cross_reference: NDFRT:N0000166090
database_cross_reference: SNMI:C-10070
database_cross_reference: SNOMEDCT_US:33638001

Radioisotopes
type: Class
subclass of: Isotopes
MCID: MC00011108
PMOID: PMO:00015446
Subclass_of: Isotopes
Synonym: Isotopes, Radioactive
Synonym: Radioactive Isotopes
Synonym: Radioactive isotope
Synonym: Radioactive isotope (substance)
Synonym: Radioisotope
Synonym: Radioisotope, NOS
Synonym: Radioisotopes [Chemical/Ingredient]
Synonym: Radionuclide
Synonym: Radionuclides
Synonym: radioactive isotope
Tree Number: T6.1.9.17
database_cross_reference: AOD:0000001094
database_cross_reference: CHV:0000010546
database_cross_reference: CSP:2540-7245
database_cross_reference: LCH:U004030
database_cross_reference: LCH_NW:sh85110713
database_cross_reference: LNC:LA4385-6
database_cross_reference: LNC:LP208665-2
database_cross_reference: LNC:LP34231-8
database_cross_reference: LNC:LP35970-0
database_cross_reference: MSH:D011868
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C799
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000045856
database_cross_reference: NCI_NCI-GLOSS:CDR0000476884
database_cross_reference: NDFRT:N0000166091
database_cross_reference: SNM:E-5007
database_cross_reference: SNMI:C-10072
database_cross_reference: SNOMEDCT_US:89457008
database_cross_reference: UMD:-1919

Barium Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00001497
PMOID: PMO:00015447
Subclass_of: Radioisotopes
Synonym: Barium Radioisotopes [Chemical/Ingredient]
Synonym: Barium radioisotope
Synonym: Barium radioisotope (substance)
Synonym: Barium radioisotope, NOS
Synonym: Radioisotopes, Barium
Tree Number: T6.1.9.17.1
database_cross_reference: MSH:D001465
database_cross_reference: NDFRT:N0000166094
database_cross_reference: SNMI:C-122A0
database_cross_reference: SNOMEDCT_US:31896007

Bromine Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00001956
PMOID: PMO:00015448
Subclass_of: Radioisotopes
Synonym: Bromine Radioisotopes [Chemical/Ingredient]
Synonym: Bromine radioisotope
Synonym: Bromine radioisotope (substance)
Synonym: Bromine radioisotope, NOS
Synonym: Radioisotopes, Bromine
Tree Number: T6.1.9.17.2
database_cross_reference: MSH:D001967
database_cross_reference: NDFRT:N0000166092
database_cross_reference: SNM:E-5108
database_cross_reference: SNMI:C-113A0
database_cross_reference: SNOMEDCT_US:53393007

Cadmium Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00002090
PMOID: PMO:00015449
Subclass_of: Radioisotopes
Synonym: Cadmium Radioisotopes [Chemical/Ingredient]
Synonym: Cadmium radioisotope
Synonym: Cadmium radioisotope (substance)
Synonym: Cadmium radioisotope, NOS
Synonym: Radioisotopes, Cadmium
Tree Number: T6.1.9.17.3
database_cross_reference: MSH:D002106
database_cross_reference: NDFRT:N0000166097
database_cross_reference: SNMI:C-126A0
database_cross_reference: SNOMEDCT_US:68929009

Copper Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00003248
PMOID: PMO:00015450
Subclass_of: Radioisotopes
Synonym: Copper Radioisotopes [Chemical/Ingredient]
Synonym: Copper radioisotope
Synonym: Copper radioisotope (substance)
Synonym: Copper radioisotope, NOS
Synonym: Radioisotopes, Copper
Tree Number: T6.1.9.17.10
database_cross_reference: MSH:D003301
database_cross_reference: NDFRT:N0000166100
database_cross_reference: SNMI:C-127A0
database_cross_reference: SNOMEDCT_US:111069000

Fluorine Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00005195
PMOID: PMO:00015451
Subclass_of: Radioisotopes
Synonym: Fluorine Radioisotopes [Chemical/Ingredient]
Synonym: Fluorine radioisotope
Synonym: Fluorine radioisotope (substance)
Synonym: Fluorine radioisotope, NOS
Synonym: Radioisotopes, Fluorine
Tree Number: T6.1.9.17.12
database_cross_reference: MSH:D005462
database_cross_reference: NDFRT:N0000166102
database_cross_reference: SNM:E-5102
database_cross_reference: SNMI:C-111A0
database_cross_reference: SNOMEDCT_US:25205007

Indium Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00006803
PMOID: PMO:00015452
Subclass_of: Radioisotopes
Synonym: Indium Radioisotopes [Chemical/Ingredient]
Synonym: Indium radioisotope
Synonym: Indium radioisotope (substance)
Synonym: Indium radioisotope, NOS
Synonym: Radioisotopes, Indium
Tree Number: T6.1.9.17.15
database_cross_reference: MSH:D007205
database_cross_reference: NDFRT:N0000166099
database_cross_reference: SNMI:C-145A0
database_cross_reference: SNOMEDCT_US:26434005

Iridium Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00007042
PMOID: PMO:00015453
Subclass_of: Radioisotopes
Synonym: Iridium Radioisotopes [Chemical/Ingredient]
Synonym: Iridium radioisotope
Synonym: Iridium radioisotope (substance)
Synonym: Iridium radioisotope, NOS
Synonym: Radioisotopes, Iridium
Tree Number: T6.1.9.17.17
database_cross_reference: MSH:D007496
database_cross_reference: NDFRT:N0000166105
database_cross_reference: SNMI:C-151A0
database_cross_reference: SNOMEDCT_US:33239004

Krypton Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00007287
PMOID: PMO:00015454
Subclass_of: Radioisotopes
Synonym: Krypton Radioisotopes [Chemical/Ingredient]
Synonym: Krypton radioisotope
Synonym: Krypton radioisotope (substance)
Synonym: Krypton radioisotope, NOS
Synonym: Radioisotopes, Krypton
Tree Number: T6.1.9.17.19
database_cross_reference: MSH:D007727
database_cross_reference: NDFRT:N0000166095
database_cross_reference: SNMI:C-173A0
database_cross_reference: SNOMEDCT_US:75874000

Lead Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00007408
PMOID: PMO:00015455
Subclass_of: Radioisotopes
Synonym: Lead Radioisotopes [Chemical/Ingredient]
Synonym: Lead radioisotope
Synonym: Lead radioisotope (substance)
Synonym: Lead radioisotope, NOS
Synonym: Radioisotopes, Lead
Tree Number: T6.1.9.17.20
database_cross_reference: MSH:D007856
database_cross_reference: NDFRT:N0000166101
database_cross_reference: SNMI:C-132A0
database_cross_reference: SNOMEDCT_US:25001008

Radioactive Tracers
type: Class
subclass of: Radioisotopes
MCID: MC00011106
PMOID: PMO:00015456
Subclass_of: Radioisotopes
Synonym: Radioactive Tracers [Chemical/Ingredient]
Synonym: Radioactive tracers
Synonym: Tracers, Radioactive
Synonym: radioactive tracer
Synonym: radioactive tracers
Tree Number: T6.1.9.17.26
database_cross_reference: CHV:0000010532
database_cross_reference: LCH:U004018
database_cross_reference: LCH_NW:sh85110620
database_cross_reference: MSH:D011849
database_cross_reference: NDFRT:N0000166093

Rubidium Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00011518
PMOID: PMO:00015457
Subclass_of: Radioisotopes
Synonym: Radioisotopes, Rubidium
Synonym: Rubidium Radioisotopes [Chemical/Ingredient]
Synonym: Rubidium radioisotope
Synonym: Rubidium radioisotope (substance)
Synonym: Rubidium radioisotope, NOS
Tree Number: T6.1.9.17.27
database_cross_reference: MSH:D012414
database_cross_reference: NDFRT:N0000166103
database_cross_reference: SNMI:C-159A0
database_cross_reference: SNOMEDCT_US:84342004

Ruthenium Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00011530
PMOID: PMO:00015458
Subclass_of: Radioisotopes
Synonym: Radioisotopes, Ruthenium
Synonym: Ruthenium Radioisotopes [Chemical/Ingredient]
Synonym: Ruthenium radioisotope
Synonym: Ruthenium radioisotope (substance)
Synonym: Ruthenium radioisotope, NOS
Tree Number: T6.1.9.17.28
database_cross_reference: MSH:D012429
database_cross_reference: NDFRT:N0000166104
database_cross_reference: SNMI:C-180A0
database_cross_reference: SNOMEDCT_US:35151007

Selenium Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00011716
PMOID: PMO:00015459
Subclass_of: Radioisotopes
Synonym: Radioisotopes, Selenium
Synonym: Selenium Radioisotopes [Chemical/Ingredient]
Synonym: Selenium radioisotope
Synonym: Selenium radioisotope (substance)
Synonym: Selenium radioisotope, NOS
Tree Number: T6.1.9.17.29
database_cross_reference: MSH:D012644
database_cross_reference: NDFRT:N0000166098
database_cross_reference: SNM:E-5132
database_cross_reference: SNMI:C-116A0
database_cross_reference: SNOMEDCT_US:23459009

Thallium Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00012686
PMOID: PMO:00015460
Subclass_of: Radioisotopes
Synonym: Radioisotopes, Thallium
Synonym: Thallium Radioisotopes [Chemical/Ingredient]
Synonym: Thallium radioisotope
Synonym: Thallium radioisotope (substance)
Synonym: Thallium radioisotope, NOS
Tree Number: T6.1.9.17.33
database_cross_reference: MSH:D013794
database_cross_reference: NDFRT:N0000166106
database_cross_reference: SNMI:C-138A0
database_cross_reference: SNOMEDCT_US:90841008

Tin Radioisotopes
type: Class
subclass of: Radioisotopes
MCID: MC00012870
PMOID: PMO:00015461
Subclass_of: Radioisotopes
Synonym: Radioisotopes, Tin
Synonym: Tin Radioisotopes [Chemical/Ingredient]
Synonym: Tin radioisotope
Synonym: Tin radioisotope (substance)
Synonym: Tin radioisotope, NOS
Tree Number: T6.1.9.17.34
database_cross_reference: MSH:D014004
database_cross_reference: NDFRT:N0000166096
database_cross_reference: SNMI:C-139A0
database_cross_reference: SNOMEDCT_US:85369009

Metals
type: Class
subclass of: Inorganic Chemicals
MCID: MC00008134
PMOID: PMO:00015462
Subclass_of: Inorganic Chemicals
Synonym: Metal
Synonym: Metal (element)
Synonym: Metal (element) (substance)
Synonym: Metal (element, substance) (substance)
Synonym: Metal (substance)
Synonym: Metal element
Synonym: Metal element (substance)
Synonym: Metal, NOS
Synonym: Metallic Elements
Synonym: Metals [Chemical/Ingredient]
Tree Number: T6.1.10
database_cross_reference: AOD:0000019451
database_cross_reference: CHV:0000008005
database_cross_reference: CSP:1852-5843
database_cross_reference: LCH:U002929
database_cross_reference: LCH_NW:sh85084167
database_cross_reference: LNC:LP21226-3
database_cross_reference: MSH:D008670
database_cross_reference: NCI:C637
database_cross_reference: NDFRT:N0000008237
database_cross_reference: PSY:31050
database_cross_reference: PSY:31052
database_cross_reference: RCD:Ua0zf
database_cross_reference: RCD:X79A3
database_cross_reference: SNMI:C-11800
database_cross_reference: SNOMEDCT_US:255751005
database_cross_reference: SNOMEDCT_US:425620007
database_cross_reference: SNOMEDCT_US:72761006

Alloys
type: Class
subclass of: Metals
subclass of: PMO:00024401
MCID: MC00000591
PMOID: PMO:00015463
Subclass_of: Biomedical and Dental Materials
Subclass_of: Metals
Synonym: Alloy
Synonym: Alloys [Chemical/Ingredient]
Synonym: Metallic alloy
Synonym: Metallic alloy (substance)
Synonym: Metallic alloy, NOS
Synonym: alloy
Synonym: alloys
Tree Number: T6.1.10.1
Tree Number: T6.14.1
database_cross_reference: CHV:0000000919
database_cross_reference: CSP:1852-6667
database_cross_reference: LCH:U000157
database_cross_reference: LCH_NW:sh85003721
database_cross_reference: MSH:D000497
database_cross_reference: NDFRT:N0000171551
database_cross_reference: RCD:XM0Em
database_cross_reference: SNMI:C-11811
database_cross_reference: SNOMEDCT_US:56427006
database_cross_reference: UMD:16-392

Chromium Alloys
type: Class
subclass of: Alloys
subclass of: Chromium Compounds
subclass of: PMO:00024408
MCID: MC00002809
PMOID: PMO:00015464
Subclass_of: Alloys
Subclass_of: Chromium Compounds
Subclass_of: Dental Alloys
Synonym: Alloys, Chromium
Synonym: Chromium Alloys [Chemical/Ingredient]
Synonym: Chromium alloys
Tree Number: T6.1.10.1.1
Tree Number: T6.1.22.2
Tree Number: T6.14.1.1
Tree Number: T6.14.5.1.1
database_cross_reference: LCH:U001010
database_cross_reference: LCH_NW:sh85025354
database_cross_reference: MSH:D002858
database_cross_reference: NDFRT:N0000171555

Vitallium
type: Class
subclass of: Chromium Alloys
MCID: MC00013623
PMOID: PMO:00015465
Subclass_of: Chromium Alloys
Synonym: Cobalt alloy, base, Co 56-68,Cr 25.00-29.00,Mo 5.00-6.00,Ni 1.75-3.75,Fe 0-3.00,Mn 0-1.00,Si 0-1.00,C 0.20-0.30,B 0-0.007 (UNS R30021)
Synonym: Vitallium [Chemical/Ingredient]
Tree Number: T6.1.22.2.1
Tree Number: T6.14.1.1.1
database_cross_reference: MSH:D014800
database_cross_reference: NDFRT:N0000171556

Gold Alloys
type: Class
subclass of: Alloys
subclass of: Gold Compounds
subclass of: PMO:00024408
MCID: MC00005786
PMOID: PMO:00015466
Subclass_of: Alloys
Subclass_of: Dental Alloys
Subclass_of: Gold Compounds
Synonym: Alloys, Gold
Synonym: Au - Gold alloy
Synonym: Gold Alloys [Chemical/Ingredient]
Synonym: Gold alloy
Synonym: Gold alloy (substance)
Synonym: Gold alloys
Synonym: High-gold content alloy
Synonym: High-gold content alloy (substance)
Tree Number: T6.1.10.1.2
Tree Number: T6.1.26.1
Tree Number: T6.14.1.2
Tree Number: T6.14.5.1.3
database_cross_reference: LCH:U002019
database_cross_reference: LCH_NW:sh85055704
database_cross_reference: MSH:D006047
database_cross_reference: NDFRT:N0000171552
database_cross_reference: RCD:X79Tg
database_cross_reference: RCD:X79Th
database_cross_reference: SNOMEDCT_US:256496006
database_cross_reference: SNOMEDCT_US:256497002

Steel
type: Class
subclass of: Alloys
subclass of: Iron Compounds
MCID: MC00012212
PMOID: PMO:00015467
Subclass_of: Alloys
Subclass_of: Iron Compounds
Synonym: Steel [Chemical/Ingredient]
Synonym: Steels
Synonym: steel
Synonym: steeling
Synonym: steels
Tree Number: T6.1.10.1.3
Tree Number: T6.1.49.3
Tree Number: T6.14.1.3
database_cross_reference: CHV:0000011714
database_cross_reference: CSP:1852-6667
database_cross_reference: LCH:U004470
database_cross_reference: LCH_NW:sh85127749
database_cross_reference: MSH:D013232
database_cross_reference: NDFRT:N0000171557

Stainless Steel
type: Class
subclass of: Steel
MCID: MC00012179
PMOID: PMO:00015468
Subclass_of: Steel
Synonym: SS - Stainless steel
Synonym: Stainless Steel [Chemical/Ingredient]
Synonym: Stainless steel
Synonym: Stainless steel material
Synonym: Stainless steel material (substance)
Synonym: Steel, Stainless
Synonym: stainless steel
Tree Number: T6.1.49.3.1
Tree Number: T6.14.1.3.1
database_cross_reference: CHV:0000011681
database_cross_reference: LCH_NW:sh85127793
database_cross_reference: MSH:D013193
database_cross_reference: NDFRT:N0000171558
database_cross_reference: RCD:X79Tr
database_cross_reference: SNOMEDCT_US:256506002

Metal Ceramic Alloys
type: Class
subclass of: Alloys
subclass of: PMO:00024408
MCID: MC00043287
PMOID: PMO:00015469
Subclass_of: Alloys
Subclass_of: Dental Alloys
Synonym: Alloy, Metal Ceramic
Synonym: Alloy, Metallo-Ceramic
Synonym: Alloy, Metalloceramic
Synonym: Alloys, Metal Ceramic
Synonym: Alloys, Metallo-Ceramic
Synonym: Alloys, Metalloceramic
Synonym: Alloys, Porcelain-Metal
Synonym: Bonding alloy
Synonym: Metal Ceramic Alloy
Synonym: Metal Ceramic Alloys [Chemical/Ingredient]
Tree Number: T6.1.10.1.4
Tree Number: T6.14.1.4
Tree Number: T6.14.5.1.4
database_cross_reference: MSH:D016876
database_cross_reference: NDFRT:N0000171553
database_cross_reference: RCD:X79Th
database_cross_reference: SNOMEDCT_US:256497002

Cermet Cements
type: Class
subclass of: Metal Ceramic Alloys
MCID: MC00043244
PMOID: PMO:00015470
Subclass_of: Metal Ceramic Alloys
Synonym: Cements, Cermet
Synonym: Cermet
Synonym: Cermet Cements [Chemical/Ingredient]
Synonym: cermet
Tree Number: T6.14.1.4.1
database_cross_reference: CHV:0000015526
database_cross_reference: MSH:D016722
database_cross_reference: NDFRT:N0000171554

Minerals
type: Class
subclass of: Inorganic Chemicals
MCID: MC00008325
PMOID: PMO:00015471
Subclass_of: Inorganic Chemicals
Synonym: 201 MINERALS
Synonym: MINERALS
Synonym: Mineral
Synonym: Mineral (substance)
Synonym: Mineral, NOS
Synonym: Minerals [Chemical/Ingredient]
Synonym: mineral
Synonym: minerals
Tree Number: T6.1.11
database_cross_reference: CHV:0000008160
database_cross_reference: CSP:0631-2946
database_cross_reference: LCH_NW:sh90001070
database_cross_reference: MEDLINEPLUS:4298
database_cross_reference: MSH:D008903
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C656
database_cross_reference: NCI_NCI-GLOSS:CDR0000045787
database_cross_reference: NDDF:000851
database_cross_reference: NDFRT:N0000007824
database_cross_reference: NDFRT:N0000178502
database_cross_reference: SNMI:C-20100
database_cross_reference: SNOMEDCT_US:87918000
database_cross_reference: VANDF:4028810

Calcium Carbonate
type: Class
subclass of: Minerals
subclass of: Calcium Compounds
MCID: MC00002109
PMOID: PMO:00015472
Subclass_of: Calcium Compounds
Subclass_of: Minerals
Synonym: 7 Select Antacid
Synonym: Acid Controller Complete
Synonym: Acid Controller Complete dual action
Synonym: Acid Reducer Complete
Synonym: Acid Reducer Plus Antacid
Synonym: After Dinner Antacid
Synonym: Alka-Seltzer Extra Strength Heartburn ReliefChews
Synonym: Alka-Seltzer Heartburn Plus Gas ReliefChews Tropical Punch
Synonym: Alka-Seltzer Heartburn ReliefChews
Synonym: Alka-Seltzer Heartburn ReliefChews Cool Mint
Tree Number: T6.1.11.2
Tree Number: T6.1.24.1
database_cross_reference: ATC:A02AC01
database_cross_reference: ATC:A12AA04
database_cross_reference: CHV:0000002293
database_cross_reference: CSP:0530-8082
database_cross_reference: DRUGBANK:DB01373
database_cross_reference: DRUGBANK:DB06724
database_cross_reference: LCH:U000741
database_cross_reference: LCH_NW:sh85018780
database_cross_reference: LNC:LP16845-7
database_cross_reference: MEDCIN:133275
database_cross_reference: MEDCIN:78268
database_cross_reference: MMSL:10153
database_cross_reference: MMSL:4326
database_cross_reference: MMSL:4330
database_cross_reference: MMSL:6070
database_cross_reference: MMSL:d00425
database_cross_reference: MSH:D002119
database_cross_reference: MTHSPL:H0G9379FGK
database_cross_reference: NCI:C332
database_cross_reference: NCI_DCP:00336
database_cross_reference: NCI_FDA:H0G9379FGK
database_cross_reference: NCI_NCI-GLOSS:CDR0000045239
database_cross_reference: NDDF:000773
database_cross_reference: NDDF:001117
database_cross_reference: NDFRT:N0000006514
database_cross_reference: NDFRT:N0000146023
database_cross_reference: NDFRT:N0000147304
database_cross_reference: NDFRT:N0000147306
database_cross_reference: PDQ:CDR0000039679
database_cross_reference: RCD:ij2..
database_cross_reference: RXNORM:1897
database_cross_reference: SNM:E-8216
database_cross_reference: SNMI:C-84221
database_cross_reference: SNOMEDCT_US:387307005
database_cross_reference: SNOMEDCT_US:55217007
database_cross_reference: VANDF:4017644
database_cross_reference: VANDF:4019033
database_cross_reference: VANDF:4019035

Nacre
type: Class
subclass of: Calcium Carbonate
MCID: MC00849061
PMOID: PMO:00015473
Subclass_of: Calcium Carbonate
Synonym: Mother of Pearl
Synonym: Mother-of-pearl
Synonym: Nacre [Chemical/Ingredient]
Tree Number: T6.1.11.2.1
Tree Number: T6.1.24.1.1
database_cross_reference: LCH_NW:sh85087521
database_cross_reference: MSH:D060734
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000183547

Calcium Sulfate
type: Class
subclass of: Minerals
subclass of: Calcium Compounds
MCID: MC00002136
PMOID: PMO:00015474
Subclass_of: Calcium Compounds
Subclass_of: Minerals
Synonym: CALCIUM (AS SULFATE)
Synonym: CALCIUM SULFATE
Synonym: CALCIUM SULFATE, UNSPECIFIED
Synonym: CALCIUM SULFATE, UNSPECIFIED FORM
Synonym: Calcium Sulfate Anhydrous
Synonym: Calcium Sulfate [Chemical/Ingredient]
Synonym: Calcium Sulfate, Unspecified Form
Synonym: Calcium Sulfate, Unspecified form
Synonym: Calcium Sulphate
Synonym: Calcium sulfate
Tree Number: T6.1.11.3
Tree Number: T6.1.24.6
database_cross_reference: CHV:0000002309
database_cross_reference: LCH_NW:sh85018793
database_cross_reference: MSH:D002133
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:E934B3V59H
database_cross_reference: MTHSPL:WAT0DDB505
database_cross_reference: NCI:C65280
database_cross_reference: NCI_FDA:WAT0DDB505
database_cross_reference: NDDF:000782
database_cross_reference: NDFRT:N0000006584
database_cross_reference: NDFRT:N0000146059
database_cross_reference: NDFRT:N0000146074
database_cross_reference: RXNORM:1925
database_cross_reference: SNMI:C-14316
database_cross_reference: SNOMEDCT_US:2880004
database_cross_reference: SNOMEDCT_US:418745003
database_cross_reference: SNOMEDCT_US:419624005
database_cross_reference: VANDF:4017685
database_cross_reference: VANDF:4017704

Silicon Dioxide
type: Class
subclass of: Oxides
subclass of: Minerals
subclass of: Silicon Compounds
MCID: MC00011857
PMOID: PMO:00015475
Subclass_of: Minerals
Subclass_of: Oxides
Subclass_of: Silicon Compounds
Synonym: Cristobalite
Synonym: Dioxide, Silicon
Synonym: Light Anhydrous Silicic Acid
Synonym: SILICON DIOXIDE
Synonym: SILICON DIOXIDE [VA Product]
Synonym: Sand
Synonym: Sand (substance)
Synonym: Silica
Synonym: Silica (SiO2)
Synonym: Silicon Dioxide [Chemical/Ingredient]
Tree Number: T6.1.11.6
Tree Number: T6.1.18.1.9
Tree Number: T6.1.29.2
database_cross_reference: CHV:0000011343
database_cross_reference: DRUGBANK:DB11132
database_cross_reference: LCH:U004313
database_cross_reference: LCH_NW:sh85122495
database_cross_reference: LNC:LP36406-4
database_cross_reference: LNC:MTHU019423
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D012822
database_cross_reference: MTH:U002242
database_cross_reference: MTHSPL:ETJ7Z6XBU4
database_cross_reference: NCI:C29853
database_cross_reference: NCI_FDA:ETJ7Z6XBU4
database_cross_reference: NDDF:005872
database_cross_reference: NDFRT:N0000006148
database_cross_reference: NDFRT:N0000145795
database_cross_reference: NDFRT:N0000158434
database_cross_reference: RCD:X7989
database_cross_reference: RCD:XC0RJ
database_cross_reference: RXNORM:9771
database_cross_reference: SNM:E-5095
database_cross_reference: SNMI:C-10955
database_cross_reference: SNOMEDCT_US:128489003
database_cross_reference: SNOMEDCT_US:83581005
database_cross_reference: VANDF:4010521
database_cross_reference: VANDF:4024439

Diatomaceous Earth
type: Class
subclass of: Silicon Dioxide
MCID: MC00007261
PMOID: PMO:00015476
Subclass_of: Silicon Dioxide
Synonym: DIATOMACEOUS EARTH
Synonym: Diatomaceous Earth [Chemical/Ingredient]
Synonym: Diatomaceous earth
Synonym: Earth, Diatomaceous
Synonym: Earth, Infusorial
Synonym: Fossil flour
Synonym: Infusorial Earth
Synonym: Infusorial earth
Synonym: Infusorial earth (substance)
Synonym: Kieselguhr
Tree Number: T6.1.11.6.1
Tree Number: T6.1.29.2.1
database_cross_reference: LCH:U005714
database_cross_reference: LCH_NW:sh85037626
database_cross_reference: MSH:D007692
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2RF6EJ0M85
database_cross_reference: NDFRT:N0000166297
database_cross_reference: RXNORM:1362874
database_cross_reference: SNM:E-8233
database_cross_reference: SNMI:C-10957
database_cross_reference: SNOMEDCT_US:33817009

Quartz
type: Class
subclass of: Silicon Dioxide
MCID: MC00011055
PMOID: PMO:00015477
Subclass_of: Silicon Dioxide
Synonym: Quartz (SiO2)
Synonym: Quartz (substance)
Synonym: Quartz [Chemical/Ingredient]
Synonym: quartz
Tree Number: T6.1.11.6.2
Tree Number: T6.1.29.2.2
database_cross_reference: CHV:0000010486
database_cross_reference: LCH:U003989
database_cross_reference: LCH_NW:sh85109732
database_cross_reference: MSH:D011791
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44441
database_cross_reference: NDFRT:N0000166298
database_cross_reference: SNMI:C-10956
database_cross_reference: SNOMEDCT_US:64827004

Silicates
type: Class
subclass of: Minerals
MCID: MC00043854
PMOID: PMO:00015478
Subclass_of: Minerals
Synonym: SILICATE
Synonym: Silicate
Synonym: Silicate salt
Synonym: Silicate salt (substance)
Synonym: Silicate salt, NOS
Synonym: Silicates [Chemical/Ingredient]
Synonym: silicate
Synonym: silicates
Tree Number: T6.1.11.7
database_cross_reference: CHV:0000016053
database_cross_reference: CSP:2706-2977
database_cross_reference: LCH:U006142
database_cross_reference: LCH_NW:sh85122503
database_cross_reference: LNC:LP16834-1
database_cross_reference: LNC:MTHU008026
database_cross_reference: MSH:D017640
database_cross_reference: NDFRT:N0000007392
database_cross_reference: NDFRT:N0000022759
database_cross_reference: RCD:X798A
database_cross_reference: SNM:E-5094
database_cross_reference: SNMI:C-10960
database_cross_reference: SNOMEDCT_US:55972001
database_cross_reference: VANDF:4020396

Aluminum Silicates
type: Class
subclass of: Silicates
subclass of: Aluminum Oxide
MCID: MC00000687
PMOID: PMO:00015479
Subclass_of: Aluminum Oxide
Subclass_of: Silicates
Synonym: Aluminum Silicates [Chemical/Ingredient]
Synonym: Aluminum silicate
Synonym: Aluminum silicates
Synonym: Silicates, Aluminum
Tree Number: T6.1.11.7.1
Tree Number: T6.1.21.3.1
database_cross_reference: LCH:U000172
database_cross_reference: LCH_NW:sh85004034
database_cross_reference: MSH:D000538
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007657
database_cross_reference: SNM:E-5143

Asbestos
type: Class
subclass of: Silicates
MCID: MC00001284
PMOID: PMO:00015483
Subclass_of: Silicates
Synonym: Asbestos (substance)
Synonym: Asbestos [Chemical/Ingredient]
Synonym: Asbestos fibers
Synonym: Asbestos fibers, NOS
Synonym: Asbestos fibres
Synonym: Asbestos, NOS
Synonym: asbestos
Synonym: asbestos fiber
Synonym: asbestos fibers
Tree Number: T6.1.11.7.2
database_cross_reference: CHV:0000001493
database_cross_reference: CSP:2706-3602
database_cross_reference: LCH:U000385
database_cross_reference: LCH_NW:sh85008511
database_cross_reference: LNC:LA15923-8
database_cross_reference: LNC:LP18896-8
database_cross_reference: LNC:MTHU017387
database_cross_reference: MEDLINEPLUS:1330
database_cross_reference: MSH:D001194
database_cross_reference: NCI:C284
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046528
database_cross_reference: NDFRT:N0000166292
database_cross_reference: PSY:03965
database_cross_reference: RCD:X79D5
database_cross_reference: SNM:E-5301
database_cross_reference: SNMI:C-20110
database_cross_reference: SNOMEDCT_US:16369005

Asbestos, Serpentine
type: Class
subclass of: Magnesium Silicates
MCID: MC00055842
PMOID: PMO:00015484
Subclass_of: Magnesium Silicates
Synonym: Asbestos, Serpentine [Chemical/Ingredient]
Synonym: SERPENTINE
Synonym: Serpentine
Synonym: Serpentine (Mineral)
Synonym: Serpentine Asbestos
Synonym: Serpentine asbestos
Synonym: Serpentine asbestos (substance)
Synonym: Serpentine asbestos, NOS
Tree Number: T6.1.28.6.2
database_cross_reference: LCH_NW:sh85120306
database_cross_reference: MSH:D017632
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166296
database_cross_reference: SNMI:C-20111
database_cross_reference: SNOMEDCT_US:86180007

Asbestos, Amosite
type: Class
subclass of: Magnesium Silicates
MCID: MC00020072
PMOID: PMO:00015487
Subclass_of: Magnesium Silicates
Synonym: Amosite
Synonym: Amosite (substance)
Synonym: Amosite Asbestos
Synonym: Asbestos, Amosite [Chemical/Ingredient]
Synonym: Asbestos, grunerite
Tree Number: T6.1.28.6.3
database_cross_reference: LCH_NW:sh85004586
database_cross_reference: MSH:D017639
database_cross_reference: NCI:C45527
database_cross_reference: NCI:TCGA
database_cross_reference: NDFRT:N0000166295
database_cross_reference: RCD:X79D6
database_cross_reference: SNMI:C-20114
database_cross_reference: SNOMEDCT_US:68753007

Magnesium Silicates
type: Class
subclass of: Silicates
subclass of: Magnesium Compounds
MCID: MC00067299
PMOID: PMO:00015488
Subclass_of: Magnesium Compounds
Subclass_of: Silicates
Synonym: Magnesium Silicates [Chemical/Ingredient]
Synonym: Silicates, Magnesium
Tree Number: T6.1.11.7.3
Tree Number: T6.1.28.6
database_cross_reference: MSH:D017633
database_cross_reference: NDFRT:N0000007817

Talc
type: Class
subclass of: Magnesium Silicates
MCID: MC00012545
PMOID: PMO:00015489
Subclass_of: Magnesium Silicates
Synonym: AHC Premium Intense Contour Balm
Synonym: Baby
Synonym: Budpak Baby
Synonym: Careline Perfect Care BB
Synonym: Face It Hd Perfect Bb Spf30 Pa 01
Synonym: Face It Hd Perfect Bb Spf30 Pa 02
Synonym: Foot Spray With Powder
Synonym: Foot and Body Powder
Synonym: Fresh Scent Protective Powder
Synonym: Health Smart Baby
Tree Number: T6.1.28.6.1
database_cross_reference: CHV:0000012022
database_cross_reference: DRUGBANK:DB09511
database_cross_reference: LCH:U004575
database_cross_reference: LCH_NW:sh85132075
database_cross_reference: MEDCIN:250645
database_cross_reference: MEDCIN:258070
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D013627
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7SEV7J4R1U
database_cross_reference: NCI:C854
database_cross_reference: NCI_FDA:7SEV7J4R1U
database_cross_reference: NCI_NCI-GLOSS:CDR0000470254
database_cross_reference: NDDF:001919
database_cross_reference: NDFRT:N0000007033
database_cross_reference: NDFRT:N0000147573
database_cross_reference: PDQ:CDR0000042168
database_cross_reference: RCD:X79Cy
database_cross_reference: RXNORM:10323
database_cross_reference: SNM:E-8042
database_cross_reference: SNMI:C-14821
database_cross_reference: SNOMEDCT_US:1557002
database_cross_reference: SNOMEDCT_US:409109009
database_cross_reference: VANDF:4019447

Mineral Fibers
type: Class
subclass of: Minerals
MCID: MC00099013
PMOID: PMO:00015490
Subclass_of: Minerals
Synonym: Fiber, Mineral
Synonym: Fibers, Mineral
Synonym: Mineral Fiber
Synonym: Mineral Fibers [Chemical/Ingredient]
Synonym: mineral fiber
Synonym: mineral fibers
Tree Number: T6.1.11.8
database_cross_reference: CHV:0000027659
database_cross_reference: MSH:D019016
database_cross_reference: NDFRT:N0000166281

Ferrosoferric Oxide
type: Class
subclass of: Minerals
subclass of: Ferric Compounds
subclass of: Ferrous Compounds
MCID: MC00884674
PMOID: PMO:00015491
Subclass_of: Ferric Compounds
Subclass_of: Ferrous Compounds
Subclass_of: Minerals
Synonym: Black Iron Oxide
Synonym: Black iron oxide
Synonym: C.I. 77499
Synonym: FERRIC OXIDE BLACK
Synonym: FERRIC OXIDE Black
Synonym: FERROSOFERRIC OXIDE
Synonym: Ferric Oxide Black
Synonym: Ferriferrous Oxide
Synonym: Ferrosoferric Oxide [Chemical/Ingredient]
Synonym: Ferrosoferric oxide
Tree Number: T6.1.11.9
Tree Number: T6.1.49.1.2
Tree Number: T6.1.49.2.2
database_cross_reference: MSH:D052203
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: MTHSPL:XM0M87F357
database_cross_reference: NCI:C38138
database_cross_reference: NCI_FDA:XM0M87F357
database_cross_reference: NDDF:010253
database_cross_reference: NDFRT:N0000166280
database_cross_reference: RXNORM:1310708
database_cross_reference: SNMI:C-13016
database_cross_reference: SNOMEDCT_US:51922007

Magnetite Nanoparticles
type: Class
subclass of: Ferrosoferric Oxide
MCID: MC00744222
PMOID: PMO:00015492
Subclass_of: Ferrosoferric Oxide
Synonym: Magnetite Nanoparticle
Synonym: Magnetite Nanoparticles [Chemical/Ingredient]
Synonym: Nanoparticle, Magnetite
Synonym: Nanoparticles, Magnetite
Tree Number: T6.1.11.9.1
database_cross_reference: MSH:D058185
database_cross_reference: NDFRT:N0000182084

Salts
type: Class
subclass of: Inorganic Chemicals
MCID: MC00011579
PMOID: PMO:00015493
Subclass_of: Inorganic Chemicals
Synonym: Salt
Synonym: Salts [Chemical/Ingredient]
Synonym: salt
Synonym: salts
Tree Number: T6.1.12
database_cross_reference: AOD:0000019263
database_cross_reference: CHV:0000011031
database_cross_reference: CSP:0631-3572
database_cross_reference: LCH:U004201
database_cross_reference: LCH_NW:sh85116900
database_cross_reference: MSH:D012492
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C822
database_cross_reference: NDFRT:N0000166153

Sulfur Compounds
type: Class
subclass of: Inorganic Chemicals
subclass of: Organic Chemicals
MCID: MC00012412
PMOID: PMO:00015494
Subclass_of: Inorganic Chemicals
Subclass_of: Organic Chemicals
Synonym: Compounds, Sulfur
Synonym: SULFUR CPDS
Synonym: Sulfur Compounds [Chemical/Ingredient]
Synonym: Sulfur compound
Synonym: Sulfur compound (substance)
Synonym: Sulfur compound [dup] (substance)
Synonym: Sulfur compound, NOS
Synonym: Sulfur compounds
Synonym: Sulphur compound
Synonym: compound sulphur
Tree Number: T6.1.13
Tree Number: T6.2.32
database_cross_reference: CHV:0000011876
database_cross_reference: CSP:2842-2775
database_cross_reference: LCH_NW:sh85130373
database_cross_reference: MSH:D013457
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008249
database_cross_reference: SNMI:C-10810
database_cross_reference: SNOMEDCT_US:111064005
database_cross_reference: SNOMEDCT_US:276171004

Carbon Disulfide
type: Class
subclass of: Carbon Compounds, Inorganic
MCID: MC00002238
PMOID: PMO:00015495
Subclass_of: Carbon Compounds, Inorganic
Synonym: CARBON DISULFIDE
Synonym: Carbon Disulfide [Chemical/Ingredient]
Synonym: Carbon bisulfide
Synonym: Carbon bisulphide
Synonym: Carbon disulfide
Synonym: Carbon disulfide (substance)
Synonym: Carbon disulfide [dup] (substance)
Synonym: Carbon disulphide
Synonym: Disulfide, Carbon
Synonym: carbon disulfide
Tree Number: T6.1.16.2
database_cross_reference: CHV:0000002394
database_cross_reference: LCH:U005284
database_cross_reference: LCH_NW:sh85020116
database_cross_reference: LNC:LP14350-0
database_cross_reference: LNC:MTHU007991
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D002246
database_cross_reference: MTH:U001781
database_cross_reference: MTHSPL:S54S8B99E8
database_cross_reference: NCI:C29813
database_cross_reference: NCI_DCP:00814
database_cross_reference: NCI_FDA:S54S8B99E8
database_cross_reference: NDDF:015251
database_cross_reference: NDFRT:N0000166211
database_cross_reference: RCD:X809M
database_cross_reference: RCDAE:X809M
database_cross_reference: RXNORM:1311478
database_cross_reference: SNM:E-5067
database_cross_reference: SNMI:C-10515
database_cross_reference: SNOMEDCT_US:259144004
database_cross_reference: SNOMEDCT_US:6044000

Alum Compounds
type: Class
subclass of: Aluminum Compounds
MCID: MC00000677
PMOID: PMO:00015496
Subclass_of: Aluminum Compounds
Synonym: ALUM CPDS
Synonym: Alum Compounds [Chemical/Ingredient]
Synonym: Compounds, Alum
Tree Number: T6.1.21.1
database_cross_reference: MSH:D000534
database_cross_reference: NDFRT:N0000007655

Ammonium Sulfate
type: Class
subclass of: Ammonium Compounds
MCID: MC00000795
PMOID: PMO:00015497
Subclass_of: Ammonium Compounds
Synonym: AMMONIUM SULFATE
Synonym: Ammonium Sulfate [Chemical/Ingredient]
Synonym: Ammonium sulfate
Synonym: Ammonium sulfate (substance)
Synonym: Ammonium sulphate
Synonym: Sulfate, Ammonium
Synonym: Sulfuric acid diammonium salt
Synonym: ammonium sulfate
Tree Number: T6.1.33.11.3
database_cross_reference: CHV:0000001031
database_cross_reference: LCH_NW:sh96011270
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000645
database_cross_reference: MTHSPL:SU46BAM238
database_cross_reference: NCI:C76740
database_cross_reference: NCI_FDA:SU46BAM238
database_cross_reference: NDDF:005436
database_cross_reference: NDFRT:N0000166204
database_cross_reference: RXNORM:1362695
database_cross_reference: SNOMEDCT_US:412087001

Barium Sulfate
type: Class
subclass of: Barium Compounds
MCID: MC00001498
PMOID: PMO:00015498
Subclass_of: Barium Compounds
Synonym: Anatrast Pst 55%
Synonym: BARIUM SULFATE
Synonym: Baricon for Suspension
Synonym: Barium Sulfate [Chemical/Ingredient]
Synonym: Barium sulfate
Synonym: Barium sulfate (product)
Synonym: Barium sulfate (substance)
Synonym: Barium sulfate [dup] (substance)
Synonym: Barium sulphate
Synonym: Barium sulphate (product)
Tree Number: T6.1.23.1
database_cross_reference: CHV:0000001702
database_cross_reference: DRUGBANK:DB11150
database_cross_reference: LCH_NW:sh85011860
database_cross_reference: MMSL:4245
database_cross_reference: MMSL:740
database_cross_reference: MMSL:d01445
database_cross_reference: MSH:D001466
database_cross_reference: MTHSPL:25BB7EKE2E
database_cross_reference: NCI:C28859
database_cross_reference: NCI_FDA:25BB7EKE2E
database_cross_reference: NDDF:001100
database_cross_reference: NDFRT:N0000006747
database_cross_reference: NDFRT:N0000146525
database_cross_reference: PDQ:CDR0000483042
database_cross_reference: RCD:x02JW
database_cross_reference: RCDAE:x02JW
database_cross_reference: RXNORM:1331
database_cross_reference: SNM:E-8131
database_cross_reference: SNMI:C-12217
database_cross_reference: SNOMEDCT_US:25419009
database_cross_reference: SNOMEDCT_US:353934005
database_cross_reference: SNOMEDCT_US:396014007
database_cross_reference: SNOMEDCT_US:407958001
database_cross_reference: VANDF:4018191

Magnesium Sulfate
type: Class
subclass of: Magnesium Compounds
MCID: MC00007828
PMOID: PMO:00015499
Subclass_of: Magnesium Compounds
Synonym: 50% Magnesium Sulfate Injection USP
Synonym: Assured Epsom Salt
Synonym: Calcium Lactate Et Magnesium Sulfate
Synonym: ColPrep Kit
Synonym: Eau Purgative Riga
Synonym: Epsom Salt Magnesium Sulfate
Synonym: Epsom Salt Pws 100%
Synonym: Epsom Salt Soaking Solution
Synonym: Epsom Salts Relief
Synonym: Eucalyptus Scented Natural Epsom Salt
Tree Number: T6.1.28.4
database_cross_reference: ATC:A06AD04
database_cross_reference: ATC:A12CC02
database_cross_reference: ATC:B05XA05
database_cross_reference: ATC:D11AX05
database_cross_reference: ATC:V04CC02
database_cross_reference: CHV:0000007665
database_cross_reference: CSP:1852-6512
database_cross_reference: CSP:2834-7855
database_cross_reference: DRUGBANK:DB00653
database_cross_reference: MEDCIN:41242
database_cross_reference: MMSL:5017
database_cross_reference: MMSL:7114
database_cross_reference: MMSL:d00468
database_cross_reference: MSH:D008278
database_cross_reference: MTHSPL:DE08037SAB
database_cross_reference: NCI:C623
database_cross_reference: NCI_DCP:01385
database_cross_reference: NCI_DTP:NSC0146179
database_cross_reference: NCI_FDA:DE08037SAB
database_cross_reference: NCI_NCI-GLOSS:CDR0000484434
database_cross_reference: NDDF:000789
database_cross_reference: NDDF:001184
database_cross_reference: NDFRT:N0000006351
database_cross_reference: NDFRT:N0000145856
database_cross_reference: NDFRT:N0000147424
database_cross_reference: PDQ:CDR0000038723
database_cross_reference: RCD:ae3..
database_cross_reference: RCDAE:ae3..
database_cross_reference: RXNORM:6585
database_cross_reference: SNM:E-8273
database_cross_reference: SNMI:C-848F0
database_cross_reference: SNOMEDCT_US:37400007
database_cross_reference: SNOMEDCT_US:387202002
database_cross_reference: USPMG:MTHU001748
database_cross_reference: VANDF:4017468
database_cross_reference: VANDF:4019181

Gold Sodium Thiosulfate
type: Class
subclass of: Gold Compounds
subclass of: Sodium Compounds
MCID: MC00011986
PMOID: PMO:00015500
Subclass_of: Gold Compounds
Subclass_of: Sodium Compounds
Synonym: Aurate(3-), bis(monothiosulfato(2-)-O,S)-, trisodium, (T-4)-
Synonym: Aurothiosulfate, Sodium
Synonym: Bis(monothiosulfato(2-)-O,S)aurate(3-) Trisodium
Synonym: GOLD SODIUM THIOSULFATE
Synonym: Gold Sodium Thiosulfate [Chemical/Ingredient]
Synonym: Gold Thiosulfate, Sodium
Synonym: Gold sodium thiosulfate
Synonym: Gold sodium thiosulfate (in water)
Synonym: Gold sodium thiosulfate (in water) (product)
Synonym: Gold sodium thiosulfate (in water) (substance)
Tree Number: T6.1.26.2
Tree Number: T6.1.31.4
database_cross_reference: ATC:M01CB02
database_cross_reference: MEDCIN:199074
database_cross_reference: MSH:D012971
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:CKS1YQ9W1J
database_cross_reference: NDDF:006964
database_cross_reference: NDFRT:N0000166205
database_cross_reference: RCD:X79GE
database_cross_reference: RCD:X79Hf
database_cross_reference: RCDAE:X79GE
database_cross_reference: RCDAE:X79Hf
database_cross_reference: RXNORM:9876
database_cross_reference: SNMI:C-14612
database_cross_reference: SNOMEDCT_US:255938007
database_cross_reference: SNOMEDCT_US:255984002
database_cross_reference: SNOMEDCT_US:411326004
database_cross_reference: SNOMEDCT_US:411327008
database_cross_reference: SNOMEDCT_US:85494006

Zinc Sulfate
type: Class
subclass of: Zinc Compounds
MCID: MC00040910
PMOID: PMO:00015501
Subclass_of: Zinc Compounds
Synonym: 8-symptom Relief
Synonym: Allergy Eye Drops
Synonym: Anodan-HC 10mg Suppositories
Synonym: Anodan-HC Ointment
Synonym: Anodan-plus
Synonym: Anodan-plus Ointment
Synonym: Anu-aide - Ont Top 0.5%
Synonym: Anugesic-HC Ointment
Synonym: Anusol Plus Ointment
Synonym: Anusol Plus Suppositories
Tree Number: T6.1.37.2
database_cross_reference: ATC:A12CB01
database_cross_reference: CHV:0000015066
database_cross_reference: DRUGBANK:DB09322
database_cross_reference: LCH_NW:sh85149871
database_cross_reference: MEDCIN:199449
database_cross_reference: MEDCIN:41247
database_cross_reference: MMSL:1512
database_cross_reference: MMSL:5710
database_cross_reference: MMSL:d04057
database_cross_reference: MSH:D019287
database_cross_reference: MTHSPL:89DS0H96TB
database_cross_reference: NCI:C1280
database_cross_reference: NCI_DCP:01250
database_cross_reference: NCI_DTP:NSC0032677
database_cross_reference: NCI_FDA:89DS0H96TB
database_cross_reference: NCI_NCI-GLOSS:CDR0000256545
database_cross_reference: NDDF:000844
database_cross_reference: NDDF:001944
database_cross_reference: NDFRT:N0000007465
database_cross_reference: NDFRT:N0000146030
database_cross_reference: NDFRT:N0000146080
database_cross_reference: PDQ:CDR0000038721
database_cross_reference: RCD:kb7..
database_cross_reference: RCD:mii..
database_cross_reference: RCDAE:kb7..
database_cross_reference: RCDAE:mii..
database_cross_reference: RXNORM:39954
database_cross_reference: SNM:E-8014
database_cross_reference: SNMI:C-96240
database_cross_reference: SNOMEDCT_US:330847007
database_cross_reference: SNOMEDCT_US:333387008
database_cross_reference: SNOMEDCT_US:387367007
database_cross_reference: SNOMEDCT_US:6625006
database_cross_reference: VANDF:4017651
database_cross_reference: VANDF:4017710

Sulfur Oxides
type: Class
subclass of: Oxides
subclass of: Sulfur Compounds
MCID: MC00012416
PMOID: PMO:00015503
Subclass_of: Oxides
Subclass_of: Sulfur Compounds
Synonym: Oxides, Sulfur
Synonym: Sulfur Oxides [Chemical/Ingredient]
Synonym: Sulfur oxides
Synonym: oxide sulfur
Synonym: sulfur oxide
Synonym: sulfur oxides
Tree Number: T6.1.13.5
Tree Number: T6.1.18.1.10
database_cross_reference: AOD:0000019639
database_cross_reference: CHV:0000011879
database_cross_reference: CSP:2843-3076
database_cross_reference: LCH_NW:sh85130388
database_cross_reference: MSH:D013461
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166208

Technetium Tc 99m Sulfur Colloid
type: Class
subclass of: Sulfur Compounds
subclass of: Technetium Compounds
MCID: MC00012579
PMOID: PMO:00015504
Subclass_of: Sulfur Compounds
Subclass_of: Technetium Compounds
Synonym: Colloid, Tc-99m Sulfur
Synonym: Colloid, Technetium Sulfur
Synonym: Kit for the Prepartion of Technetium Tc99m Sulfur Colloid
Synonym: TC SULFUR COLLOID
Synonym: TC SULFUR COLLOID 099M
Synonym: TECHNETIUM TC SULFUR COLLOID 099M
Synonym: TECHNETIUM TC-99M SULFUR COLLOID
Synonym: Tc 99m Sulfur Colloid
Synonym: Tc 99m sulfur colloid
Synonym: Tc-99m SC
Tree Number: T6.1.13.6
Tree Number: T6.1.17.2
database_cross_reference: ATC:V09DB05
database_cross_reference: DRUGBANK:DB09397
database_cross_reference: LNC:LP208684-3
database_cross_reference: MEDCIN:224739
database_cross_reference: MSH:D013671
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:556Q0P6PB1
database_cross_reference: NCI:C856
database_cross_reference: NCI_FDA:556Q0P6PB1
database_cross_reference: NCI_NCI-GLOSS:CDR0000045558
database_cross_reference: NCI_NCI-GLOSS:CDR0000674716
database_cross_reference: NCI_NCI-GLOSS:CDR0000674717
database_cross_reference: NDFRT:N0000166203
database_cross_reference: PDQ:CDR0000042818
database_cross_reference: RXNORM:1423270
database_cross_reference: SNM:E-5278
database_cross_reference: SNMI:C-B1222
database_cross_reference: SNOMEDCT_US:5931004

Thiones
type: Class
subclass of: Inorganic Chemicals
subclass of: Sulfur Compounds
MCID: MC00012740
PMOID: PMO:00015505
Subclass_of: Inorganic Chemicals
Subclass_of: Sulfur Compounds
Synonym: Thiones [Chemical/Ingredient]
Synonym: thione
Tree Number: T6.1.14
Tree Number: T6.2.32.19
database_cross_reference: CSP:2909-3309
database_cross_reference: MSH:D013871
database_cross_reference: NDFRT:N0000166440

Phosphorus Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067586
PMOID: PMO:00015506
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Phosphorus
Synonym: PHOSPHORUS CPDS
Synonym: Phosphorus Compounds [Chemical/Ingredient]
Synonym: Phosphorus Compounds, Inorganic
Synonym: inorganic phosphorus compounds
Tree Number: T6.1.15
database_cross_reference: AOD:0000019621
database_cross_reference: MSH:D017553
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008156

Phosphines
type: Class
subclass of: Phosphorus Compounds
subclass of: Organophosphorus Compounds
MCID: MC00010109
PMOID: PMO:00015507
Subclass_of: Organophosphorus Compounds
Subclass_of: Phosphorus Compounds
Synonym: Phosphines [Chemical/Ingredient]
Tree Number: T6.1.15.1
Tree Number: T6.2.29.2
database_cross_reference: MSH:D010720
database_cross_reference: NDFRT:N0000166433

Phosphoranes
type: Class
subclass of: Phosphorus Compounds
subclass of: Organophosphorus Compounds
MCID: MC00010145
PMOID: PMO:00015508
Subclass_of: Organophosphorus Compounds
Subclass_of: Phosphorus Compounds
Synonym: Phosphoranes [Chemical/Ingredient]
Tree Number: T6.1.15.2
Tree Number: T6.2.29.4
database_cross_reference: MSH:D010753
database_cross_reference: NDFRT:N0000166423

Phosphorus, Dietary
type: Class
subclass of: Phosphorus Compounds
MCID: MC00041213
PMOID: PMO:00015509
Subclass_of: Phosphorus Compounds
Synonym: Dietary Phosphorus
Synonym: P
Synonym: PHOSPHORUS
Synonym: Phosphorus
Synonym: Phosphorus, Dietary [Chemical/Ingredient]
Synonym: dietary phosphorus
Tree Number: T6.1.15.3
database_cross_reference: CHV:0000015276
database_cross_reference: MSH:D016226
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C68277
database_cross_reference: NCI_CRCH:C68277
database_cross_reference: NCI_FDA:27YLU75U4W
database_cross_reference: NDFRT:N0000166157

Carbon Compounds, Inorganic
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067587
PMOID: PMO:00015510
Subclass_of: Inorganic Chemicals
Synonym: CARBON CPDS INORGANIC
Synonym: Carbon Compounds, Inorganic [Chemical/Ingredient]
Synonym: Compounds, Inorganic Carbon
Synonym: INORGANIC CARBON CPDS
Synonym: Inorganic Carbon Compounds
Tree Number: T6.1.16
database_cross_reference: MSH:D017554
database_cross_reference: NDFRT:N0000007639

Dry Ice
type: Class
subclass of: Carbon Dioxide
MCID: MC00004194
PMOID: PMO:00015511
Subclass_of: Carbon Dioxide
Synonym: Carbon Dioxide Snow
Synonym: Dioxide Snow, Carbon
Synonym: Dry Ice [Chemical/Ingredient]
Synonym: Dry ice
Synonym: Ice, Dry
Synonym: Snow, Carbon Dioxide
Synonym: Solid carbon dioxide
Synonym: Solid carbon dioxide (substance)
Synonym: dry ice
Synonym: solid carbon dioxide
Tree Number: T6.1.16.1.1
database_cross_reference: CHV:0000004164
database_cross_reference: LCH:U001472
database_cross_reference: LCH_NW:sh85039805
database_cross_reference: MSH:D004367
database_cross_reference: NCI:C63373
database_cross_reference: NDFRT:N0000166149
database_cross_reference: SNMI:C-10521
database_cross_reference: SNOMEDCT_US:44639001

Sodium Bicarbonate
type: Class
subclass of: Sodium Compounds
MCID: MC00037869
PMOID: PMO:00015512
Subclass_of: Sodium Compounds
Synonym: 800 Sodium Bicarbonate Powder
Synonym: Accusol 35 K0
Synonym: Accusol 35 K2
Synonym: Accusol 35 K4
Synonym: After Bite Kids
Synonym: After Bite Sensitive
Synonym: After Bite The Itch Eraser KIDS
Synonym: After Bite the Itch Eraser
Synonym: Alka Seltzer Evt
Synonym: Alka Seltzer Original
Tree Number: T6.1.31.10
database_cross_reference: ATC:B05CB04
database_cross_reference: ATC:B05XA02
database_cross_reference: CHV:0000014823
database_cross_reference: CSP:2730-2721
database_cross_reference: DRUGBANK:DB01390
database_cross_reference: LCH_NW:sh94006042
database_cross_reference: MEDCIN:198505
database_cross_reference: MEDCIN:198775
database_cross_reference: MMSL:1720
database_cross_reference: MMSL:5473
database_cross_reference: MMSL:d00440
database_cross_reference: MSH:D017693
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:8MDF5V39QO
database_cross_reference: NCI:C29457
database_cross_reference: NCI_FDA:8MDF5V39QO
database_cross_reference: NDDF:000743
database_cross_reference: NDDF:001116
database_cross_reference: NDDF:011039
database_cross_reference: NDFRT:N0000005741
database_cross_reference: NDFRT:N0000146526
database_cross_reference: RCD:a13..
database_cross_reference: RCD:x00Aq
database_cross_reference: RXNORM:36676
database_cross_reference: SNM:E-8227
database_cross_reference: SNMI:C-70410
database_cross_reference: SNOMEDCT_US:316947006
database_cross_reference: SNOMEDCT_US:387319002
database_cross_reference: SNOMEDCT_US:57376006
database_cross_reference: USPMG:MTHU001770
database_cross_reference: VANDF:4018192

Technetium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067270
PMOID: PMO:00015513
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Technetium
Synonym: TECHNETIUM CPDS
Synonym: Technetium Compounds [Chemical/Ingredient]
Synonym: Technetium compound
Synonym: Technetium compound (substance)
Synonym: Technetium compound, NOS
Synonym: Technetium compounds
Tree Number: T6.1.17
database_cross_reference: LCH_NW:sh00000215
database_cross_reference: MSH:D017556
database_cross_reference: NDFRT:N0000007640
database_cross_reference: SNMI:C-16310
database_cross_reference: SNOMEDCT_US:47379009

Sodium Pertechnetate Tc 99m
type: Class
subclass of: Technetium Compounds
MCID: MC00012578
PMOID: PMO:00015514
Subclass_of: Technetium Compounds
Synonym: Pertechnetate (99mtc) sodium
Synonym: Pertechnetate sodium Tc-99m
Synonym: SODIUM PERTECHNETATE
Synonym: SODIUM PERTECHNETATE (Tc 99m)
Synonym: SODIUM PERTECHNETATE TC 099M
Synonym: Sodium Pertechnetate (Na99mtco4)
Synonym: Sodium Pertechnetate Tc 99m [Chemical/Ingredient]
Synonym: Sodium pertechnetate (99m Tc)
Synonym: Sodium pertechnetate (Tc 99m)
Synonym: Sodium pertechnetate Tc 99m
Tree Number: T6.1.17.1
database_cross_reference: DRUGBANK:DB09314
database_cross_reference: MEDCIN:224725
database_cross_reference: MEDCIN:224738
database_cross_reference: MMSL:26801
database_cross_reference: MMSL:d07476
database_cross_reference: MSH:D013670
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:A0730CX801
database_cross_reference: NCI:C87407
database_cross_reference: NCI_FDA:A0730CX801
database_cross_reference: NDDF:009831
database_cross_reference: NDFRT:N0000007148
database_cross_reference: NDFRT:N0000146127
database_cross_reference: NDFRT:N0000146128
database_cross_reference: RXNORM:10349
database_cross_reference: SNMI:C-B1206
database_cross_reference: SNOMEDCT_US:19495007
database_cross_reference: VANDF:4017763
database_cross_reference: VANDF:4017764

Oxygen Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067588
PMOID: PMO:00015515
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Oxygen
Synonym: OXYGEN CPDS
Synonym: Oxygen Compounds [Chemical/Ingredient]
Synonym: Oxygen Compounds, Inorganic
Synonym: Oxygen compounds
Synonym: inorganic oxygen compounds
Tree Number: T6.1.18
database_cross_reference: AOD:0000019627
database_cross_reference: LCH_NW:sh2012001667
database_cross_reference: MSH:D017601
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008198

Aluminum Oxide
type: Class
subclass of: Oxides
subclass of: Aluminum Compounds
MCID: MC00000686
PMOID: PMO:00015516
Subclass_of: Aluminum Compounds
Subclass_of: Oxides
Synonym: ALUMINUM OXIDE
Synonym: Activated Aluminum Oxide
Synonym: Alumina
Synonym: Alumina / aluminum oxide
Synonym: Aluminium oxide
Synonym: Aluminium oxide - chemical
Synonym: Aluminium oxide - chemical (substance)
Synonym: Aluminum Lake
Synonym: Aluminum Oxide [Chemical/Ingredient]
Synonym: Aluminum oxide
Tree Number: T6.1.18.1.1
Tree Number: T6.1.21.3
database_cross_reference: ALT:HAABX
database_cross_reference: ATC:D10AX04
database_cross_reference: CHV:0000000959
database_cross_reference: CSP:1852-7079
database_cross_reference: DRUGBANK:DB11342
database_cross_reference: LCH:U000171
database_cross_reference: LCH_NW:sh85004029
database_cross_reference: LNC:MTHU017587
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000537
database_cross_reference: MTHSPL:LMI26O6933
database_cross_reference: NCI:C77450
database_cross_reference: NCI_FDA:LMI26O6933
database_cross_reference: NDDF:001978
database_cross_reference: NDDF:010257
database_cross_reference: NDFRT:N0000008161
database_cross_reference: RXNORM:615
database_cross_reference: SNMI:C-12013
database_cross_reference: SNOMEDCT_US:391749007
database_cross_reference: SNOMEDCT_US:418673005
database_cross_reference: SNOMEDCT_US:83881004

Sodium Hypochlorite
type: Class
subclass of: Hypochlorous Acid
subclass of: Sodium Compounds
MCID: MC00011991
PMOID: PMO:00015517
Subclass_of: Hypochlorous Acid
Subclass_of: Sodium Compounds
Synonym: Hypochlorite Sodium
Synonym: Hypochlorite, Sodium
Synonym: Hypochlorous Acid, Sodium Salt
Synonym: Hypochlorous acid, sodium salt
Synonym: SODIUM HYPOCHLORITE
Synonym: Sodium Hypochlorite (Solution)
Synonym: Sodium Hypochlorite Solution
Synonym: Sodium Hypochlorite [Chemical/Ingredient]
Synonym: Sodium hypochlorite
Synonym: Sodium hypochlorite (substance)
Tree Number: T6.1.20.5.1
Tree Number: T6.1.31.6
database_cross_reference: AOD:0000019579
database_cross_reference: ATC:D08AX07
database_cross_reference: CHV:0000011493
database_cross_reference: LCH:U004377
database_cross_reference: LCH_NW:sh86006536
database_cross_reference: MEDCIN:250648
database_cross_reference: MMSL:5230
database_cross_reference: MMSL:5485
database_cross_reference: MMX:104683
database_cross_reference: MSH:D012973
database_cross_reference: MTHSPL:DY38VHM5OD
database_cross_reference: NCI:C80658
database_cross_reference: NCI_FDA:DY38VHM5OD
database_cross_reference: NDDF:003161
database_cross_reference: NDFRT:N0000007235
database_cross_reference: NDFRT:N0000148260
database_cross_reference: RXNORM:9881
database_cross_reference: SNMI:C-23757
database_cross_reference: SNOMEDCT_US:71374001
database_cross_reference: VANDF:4020554

Magnesium Oxide
type: Class
subclass of: Oxides
subclass of: Magnesium Compounds
MCID: MC00007825
PMOID: PMO:00015518
Subclass_of: Magnesium Compounds
Subclass_of: Oxides
Synonym: Aspirin Plus Stomach Guard Ext.stgth.caplet
Synonym: Aspirin Plus Stomach Guard Extra Strength
Synonym: Aspirin Plus Stomach Guard Tab
Synonym: Aspirin With Stomach Guard
Synonym: Aspirin With Stomach Guard Extra Strength - Tab
Synonym: B6 Plus Tab
Synonym: C-apnto-B6 Vitamins W Magnesium Tab
Synonym: Calcium - Magnesium - Zinc Tab
Synonym: Calcium Magnesium Avec Vitamine D Et Zinc
Synonym: Calcium Magnesium Tab
Tree Number: T6.1.18.1.5
Tree Number: T6.1.28.3
database_cross_reference: ATC:A02AA02
database_cross_reference: ATC:A06AD02
database_cross_reference: ATC:A12CC10
database_cross_reference: CHV:0000007664
database_cross_reference: DRUGBANK:DB01377
database_cross_reference: MEDCIN:41240
database_cross_reference: MMSL:42624
database_cross_reference: MMSL:5015
database_cross_reference: MMSL:5585
database_cross_reference: MMSL:d03797
database_cross_reference: MSH:D008277
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:3A3U0GI71G
database_cross_reference: NCI:C29242
database_cross_reference: NCI_DCP:30037
database_cross_reference: NCI_FDA:3A3U0GI71G
database_cross_reference: NDDF:000788
database_cross_reference: NDDF:002435
database_cross_reference: NDFRT:N0000006347
database_cross_reference: NDFRT:N0000146020
database_cross_reference: NDFRT:N0000146086
database_cross_reference: NDFRT:N0000148146
database_cross_reference: RXNORM:6582
database_cross_reference: SNM:E-8223
database_cross_reference: SNMI:C-84233
database_cross_reference: SNOMEDCT_US:419521006
database_cross_reference: SNOMEDCT_US:66389008
database_cross_reference: VANDF:4017641
database_cross_reference: VANDF:4017717
database_cross_reference: VANDF:4020248

Osmium Tetroxide
type: Class
subclass of: Oxides
subclass of: Osmium Compounds
MCID: MC00009266
PMOID: PMO:00015519
Subclass_of: Osmium Compounds
Subclass_of: Oxides
Synonym: Acid, Osmic
Synonym: Osmic Acid
Synonym: Osmic acid
Synonym: Osmium Tetroxide [Chemical/Ingredient]
Synonym: Osmium oxide (OsO4), (T-4)-
Synonym: Osmium tetroxide
Synonym: Osmium tetroxide (substance)
Synonym: Tetroxide, Osmium
Tree Number: T6.1.18.1.7
Tree Number: T6.1.35.1
database_cross_reference: LCH_NW:sh2007005729
database_cross_reference: MSH:D009993
database_cross_reference: NDFRT:N0000166216
database_cross_reference: SNM:E-5240
database_cross_reference: SNMI:C-15211
database_cross_reference: SNOMEDCT_US:13931001

Thorium Dioxide
type: Class
subclass of: Oxides
subclass of: Thorium Compounds
MCID: MC00012777
PMOID: PMO:00015520
Subclass_of: Oxides
Subclass_of: Thorium Compounds
Synonym: Dioxide, Thorium
Synonym: Oxide, Thorium
Synonym: THORIUM DIOXIDE
Synonym: Thoria
Synonym: Thorium Anhydride
Synonym: Thorium Dioxide [Chemical/Ingredient]
Synonym: Thorium Oxide
Synonym: Thorium dioxide
Synonym: Thorium oxide
Synonym: Thorium oxide (ThO2)
Tree Number: T6.1.18.1.11
Tree Number: T6.1.39.1
database_cross_reference: LCH_NW:sh2012003207
database_cross_reference: MSH:D013911
database_cross_reference: NCI:C1449
database_cross_reference: NCI_FDA:9XA7X17UQC
database_cross_reference: NDFRT:N0000166222
database_cross_reference: SNMI:C-15711
database_cross_reference: SNOMEDCT_US:12743004

Zinc Oxide
type: Class
subclass of: Oxides
subclass of: Zinc Compounds
MCID: MC00013814
PMOID: PMO:00015521
Subclass_of: Oxides
Subclass_of: Zinc Compounds
Synonym: 01 Moisture Foundation SPF 15
Synonym: 02 Moisture Foundation SPF 15
Synonym: 03 Moisture Foundation SPF 15
Synonym: 04 Moisture Foundation SPF 15
Synonym: 05 Moisture Foundation SPF 15
Synonym: 06 Moisture Foundation SPF 15
Synonym: 07 Moisture Foundation SPF 15
Synonym: 08 Moisture Foundation SPF 15
Synonym: 100% Pure Argan Oil Moisturizer SPF 30
Synonym: 100% Pure Baby Sunscreen SPF 30
Tree Number: T6.1.18.1.13
Tree Number: T6.1.37.1
database_cross_reference: CHV:0000013279
database_cross_reference: DRUGBANK:DB00936
database_cross_reference: DRUGBANK:DB09321
database_cross_reference: LCH_NW:sh90003294
database_cross_reference: MEDCIN:199230
database_cross_reference: MEDCIN:40810
database_cross_reference: MMSL:5049
database_cross_reference: MMSL:5709
database_cross_reference: MSH:D015034
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:SOI2LOH54Z
database_cross_reference: NCI:C949
database_cross_reference: NCI_DCP:05066
database_cross_reference: NCI_FDA:SOI2LOH54Z
database_cross_reference: NCI_NCI-GLOSS:CDR0000045442
database_cross_reference: NDDF:001922
database_cross_reference: NDFRT:N0000006874
database_cross_reference: NDFRT:N0000023178
database_cross_reference: NDFRT:N0000146022
database_cross_reference: NDFRT:N0000147305
database_cross_reference: PDQ:CDR0000042277
database_cross_reference: RCD:m572.
database_cross_reference: RXNORM:11423
database_cross_reference: SNM:E-8049
database_cross_reference: SNMI:C-93360
database_cross_reference: SNOMEDCT_US:332177006
database_cross_reference: SNOMEDCT_US:398971002
database_cross_reference: SNOMEDCT_US:42841002
database_cross_reference: VANDF:4017643
database_cross_reference: VANDF:4019034
database_cross_reference: VANDF:4019036

Bromine Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067287
PMOID: PMO:00015522
Subclass_of: Inorganic Chemicals
Synonym: BROMINE CPDS
Synonym: Bromine Compounds [Chemical/Ingredient]
Synonym: Bromine compound
Synonym: Bromine compound (substance)
Synonym: Bromine compound, NOS
Synonym: Bromine compounds
Synonym: Compounds, Bromine
Tree Number: T6.1.19
database_cross_reference: LCH_NW:sh90006056
database_cross_reference: MSH:D017605
database_cross_reference: MTH:U002403
database_cross_reference: NDFRT:N0000166196
database_cross_reference: SNMI:C-11310
database_cross_reference: SNOMEDCT_US:9639005

Cyanogen Bromide
type: Class
subclass of: Nitrogen Compounds
MCID: MC00003389
PMOID: PMO:00015523
Subclass_of: Nitrogen Compounds
Synonym: Bromide, Cyanogen
Synonym: Bromine Cyanide
Synonym: Bromocyanogen
Synonym: CNBr
Synonym: CYANOGEN BROMIDE
Synonym: Cyanogen Bromide [Chemical/Ingredient]
Synonym: Cyanogen bromide
Synonym: Cyanogen bromide ((CN)Br)
Synonym: Cyanogen bromide (substance)
Synonym: cyanogen bromide
Tree Number: T6.1.33.4
database_cross_reference: CSP:0774-5316
database_cross_reference: MSH:D003488
database_cross_reference: NCI:C402
database_cross_reference: NCI_DTP:NSC0089684
database_cross_reference: NCI_FDA:OS382OHJ8P
database_cross_reference: NDFRT:N0000166199
database_cross_reference: RCD:X809g
database_cross_reference: SNOMEDCT_US:259159005

Chlorine Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067589
PMOID: PMO:00015524
Subclass_of: Inorganic Chemicals
Synonym: CHLORINE CPDS
Synonym: Chlorine Compounds [Chemical/Ingredient]
Synonym: Chlorine Compounds, Inorganic
Synonym: Compounds, Chlorine
Synonym: Compounds, Inorganic Chlorine
Synonym: Inorganic Chlorine Compounds
Synonym: chlorine compounds
Tree Number: T6.1.20
database_cross_reference: AOD:0000019590
database_cross_reference: MSH:D017606
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007794

Chloramines
type: Class
subclass of: Chlorine Compounds
subclass of: Amines
MCID: MC00002634
PMOID: PMO:00015525
Subclass_of: Amines
Subclass_of: Chlorine Compounds
Synonym: Chloramine
Synonym: Chloramine (category)
Synonym: Chloramine (category, substance) (substance)
Synonym: Chloramine (substance)
Synonym: Chloramines [Chemical/Ingredient]
Synonym: Chloroamines
Synonym: chloramine
Synonym: chloramines
Synonym: chloroamine
Tree Number: T6.1.20.1
Tree Number: T6.2.6.10
database_cross_reference: CHV:0000002813
database_cross_reference: LCH:U000966
database_cross_reference: LCH_NW:sh85024524
database_cross_reference: LNC:LP17904-1
database_cross_reference: LNC:MTHU024757
database_cross_reference: MSH:D002700
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166860
database_cross_reference: SNOMEDCT_US:116282004

Cisplatin
type: Class
subclass of: Chlorine Compounds
subclass of: Platinum Compounds
subclass of: Nitrogen Compounds
MCID: MC00002921
PMOID: PMO:00015526
Subclass_of: Chlorine Compounds
Subclass_of: Nitrogen Compounds
Subclass_of: Platinum Compounds
Synonym: (SP-4-2)-Diamminedichloroplatinum
Synonym: C.I. 77795
Synonym: CACP
Synonym: CDDP
Synonym: CDDP - Cisplatin
Synonym: CISPLATIN
Synonym: CISplatin
Synonym: CPDD
Synonym: Cis-DDP
Synonym: Cis-diammine-dichloroplatinum
Tree Number: T6.1.20.3
Tree Number: T6.1.32.1
Tree Number: T6.1.33.3
database_cross_reference: ATC:L01XA01
database_cross_reference: CHV:0000003006
database_cross_reference: CSP:1852-8933
database_cross_reference: CSP:5001-0018
database_cross_reference: DRUGBANK:DB00515
database_cross_reference: DRUGBANK:DB12117
database_cross_reference: LCH:U001035
database_cross_reference: LCH_NW:sh85026108
database_cross_reference: LNC:LP16079-3
database_cross_reference: LNC:MTHU016242
database_cross_reference: MEDCIN:48465
database_cross_reference: MMSL:31747
database_cross_reference: MMSL:4456
database_cross_reference: MMSL:d00195
database_cross_reference: MSH:D002945
database_cross_reference: MTH:U002562
database_cross_reference: MTHSPL:Q20Q21Q62J
database_cross_reference: NCI:C376
database_cross_reference: NCI:C756
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_DCP:00524
database_cross_reference: NCI_FDA:Q20Q21Q62J
database_cross_reference: NCI_NCI-GLOSS:CDR0000045230
database_cross_reference: NDDF:002641
database_cross_reference: NDFRT:N0000007062
database_cross_reference: NDFRT:N0000146476
database_cross_reference: PDQ:CDR0000039515
database_cross_reference: RCD:Xa9RU
database_cross_reference: RCD:h53..
database_cross_reference: RXNORM:2555
database_cross_reference: SNM:E-8378
database_cross_reference: SNMI:C-78060
database_cross_reference: SNOMEDCT_US:303282001
database_cross_reference: SNOMEDCT_US:387318005
database_cross_reference: SNOMEDCT_US:57066004
database_cross_reference: VANDF:4018139

Ammonium Chloride
type: Class
subclass of: Ammonium Compounds
MCID: MC00000791
PMOID: PMO:00015527
Subclass_of: Ammonium Compounds
Synonym: AMMONIUM CHLORIDE
Synonym: Acidax Inj 0.9% USP
Synonym: Acididyn Tab
Synonym: Amchlor
Synonym: Ammoniac, Sal
Synonym: Ammonium Chloride [Chemical/Ingredient]
Synonym: Ammonium Muriate
Synonym: Ammonium chloride
Synonym: Ammonium chloride ((NH4)Cl)
Synonym: Ammonium chloride (product)
Tree Number: T6.1.33.11.1
database_cross_reference: ATC:B05XA04
database_cross_reference: ATC:G04BA01
database_cross_reference: CHV:0000001030
database_cross_reference: CSP:0156-7701
database_cross_reference: DRUGBANK:DB06767
database_cross_reference: LCH_NW:sh2009008354
database_cross_reference: MMSL:4182
database_cross_reference: MMSL:5668
database_cross_reference: MMSL:d00476
database_cross_reference: MSH:D000643
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:01Q9PC255D
database_cross_reference: NCI:C47396
database_cross_reference: NCI_DCP:00274
database_cross_reference: NCI_FDA:01Q9PC255D
database_cross_reference: NDDF:000729
database_cross_reference: NDDF:002276
database_cross_reference: NDFRT:N0000005786
database_cross_reference: NDFRT:N0000146891
database_cross_reference: RXNORM:712
database_cross_reference: SNM:E-8942
database_cross_reference: SNMI:C-70210
database_cross_reference: SNOMEDCT_US:391765008
database_cross_reference: SNOMEDCT_US:419332007
database_cross_reference: SNOMEDCT_US:51366003
database_cross_reference: USPMG:MTHU001727
database_cross_reference: VANDF:4018575

Calcium Chloride
type: Class
subclass of: Calcium Compounds
MCID: MC00002113
PMOID: PMO:00015528
Subclass_of: Calcium Compounds
Synonym: (40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USP
Synonym: 10% Calcium Chloride Injection USP
Synonym: 5% Dextrose In Lactated Ringer's Injection
Synonym: Accusol 35 K0
Synonym: Accusol 35 K2
Synonym: Accusol 35 K4
Synonym: Acetate Concentrate R07376
Synonym: Acid Concentrate D12028
Synonym: Acid Concentrate D12054
Synonym: Acid Concentrate D12092
Tree Number: T6.1.24.2
database_cross_reference: ATC:A12AA07
database_cross_reference: ATC:B05XA07
database_cross_reference: ATC:G04BA03
database_cross_reference: CHV:0000002296
database_cross_reference: DRUGBANK:DB01164
database_cross_reference: LCH:U000742
database_cross_reference: LCH_NW:sh85018781
database_cross_reference: MMSL:16
database_cross_reference: MMSL:4331
database_cross_reference: MMSL:d03799
database_cross_reference: MSH:D002122
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:M4I0D6VV5M
database_cross_reference: NCI:C28901
database_cross_reference: NCI_DCP:00774
database_cross_reference: NCI_FDA:M4I0D6VV5M
database_cross_reference: NDDF:000774
database_cross_reference: NDFRT:N0000006545
database_cross_reference: NDFRT:N0000146424
database_cross_reference: RCD:x01Pb
database_cross_reference: RXNORM:1901
database_cross_reference: SNM:E-8721
database_cross_reference: SNMI:C-71016
database_cross_reference: SNOMEDCT_US:387377009
database_cross_reference: SNOMEDCT_US:68395000
database_cross_reference: VANDF:4018085

Mercuric Chloride
type: Class
subclass of: Mercury Compounds
MCID: MC00008089
PMOID: PMO:00015529
Subclass_of: Mercury Compounds
Synonym: Bichloride of mercury
Synonym: Bichloride, Mercury
Synonym: Chloride, Mercuric
Synonym: Corrosive Sublimate
Synonym: Corrosive sublimate
Synonym: Dichloride, Mercury
Synonym: HgCl2
Synonym: MERCURIC CHLORIDE
Synonym: Mercuric Chloride [Chemical/Ingredient]
Synonym: Mercuric Perchloride
Tree Number: T6.1.30.1
database_cross_reference: ATC:D08AK03
database_cross_reference: CHV:0000007976
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D008627
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:53GH7MZT1R
database_cross_reference: NCI:C80330
database_cross_reference: NCI_FDA:53GH7MZT1R
database_cross_reference: NDDF:003122
database_cross_reference: NDFRT:N0000007976
database_cross_reference: NDFRT:N0000185024
database_cross_reference: RCD:X79Ju
database_cross_reference: RXNORM:1311634
database_cross_reference: SNM:E-5188
database_cross_reference: SNMI:C-13321
database_cross_reference: SNOMEDCT_US:11496005
database_cross_reference: SNOMEDCT_US:411387005
database_cross_reference: VANDF:4031521

Potassium Chloride
type: Class
subclass of: Potassium Compounds
MCID: MC00010522
PMOID: PMO:00015530
Subclass_of: Potassium Compounds
Synonym: (20 Mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP
Synonym: (20 Mmol/l) Potassium Chloride In 5% Dextrose Injection USP
Synonym: (20 Mmol/l) Potassium Chloride In 5% Dextrose and 0.9% Sodium Chloride Injection USP
Synonym: (20mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP
Synonym: (20mmol/l) Potassium Chloride In 5% Dextrose and 0.2% Sodium Chloride Injection USP
Synonym: (20mmol/l) Potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USP
Synonym: (40 Mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP
Synonym: (40 Mmol/l) Potassium Chloride In 5% Dextrose Injection USP
Synonym: (40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USP
Synonym: (40mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP
Tree Number: T6.1.34.1
database_cross_reference: AOD:0000019585
database_cross_reference: ATC:A12BA01
database_cross_reference: ATC:B05XA01
database_cross_reference: CHV:0000010006
database_cross_reference: CSP:2390-8845
database_cross_reference: DRUGBANK:DB00761
database_cross_reference: LCH:U003783
database_cross_reference: LCH_NW:sh85105603
database_cross_reference: MEDCIN:41254
database_cross_reference: MMSL:5326
database_cross_reference: MMSL:7330
database_cross_reference: MMSL:d00345
database_cross_reference: MSH:D011189
database_cross_reference: MTHSPL:660YQ98I10
database_cross_reference: NCI:C47679
database_cross_reference: NCI_DCP:00479
database_cross_reference: NCI_FDA:660YQ98I10
database_cross_reference: NDDF:000767
database_cross_reference: NDDF:007231
database_cross_reference: NDFRT:N0000005841
database_cross_reference: NDFRT:N0000145835
database_cross_reference: NDFRT:N0000148085
database_cross_reference: NDFRT:N0000148186
database_cross_reference: RXNORM:8591
database_cross_reference: SNM:E-8725
database_cross_reference: SNMI:C-71063
database_cross_reference: SNOMEDCT_US:420155008
database_cross_reference: SNOMEDCT_US:8631001
database_cross_reference: USPMG:MTHU001756
database_cross_reference: VANDF:4017447
database_cross_reference: VANDF:4020073
database_cross_reference: VANDF:4020361

Sodium Chloride
type: Class
subclass of: Sodium Compounds
MCID: MC00011973
PMOID: PMO:00015531
Subclass_of: Sodium Compounds
Synonym: (20 Mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP
Synonym: (20 Mmol/l) Potassium Chloride In 5% Dextrose and 0.9% Sodium Chloride Injection USP
Synonym: (20mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP
Synonym: (20mmol/l) Potassium Chloride In 5% Dextrose and 0.2% Sodium Chloride Injection USP
Synonym: (20mmol/l) Potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USP
Synonym: (40 Mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP
Synonym: (40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USP
Synonym: (40mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP
Synonym: (40mmol/l)potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USP
Synonym: 0.15% Potassium Chloride In 3.3% Dextrose and 0.30% Sodium Chloride Injection
Tree Number: T6.1.31.1
database_cross_reference: AOD:0000019577
database_cross_reference: ATC:A12CA01
database_cross_reference: ATC:B05CB01
database_cross_reference: ATC:B05XA03
database_cross_reference: CHV:0000011482
database_cross_reference: CHV:0000045218
database_cross_reference: CSP:2730-4594
database_cross_reference: DRUGBANK:DB09153
database_cross_reference: LCH:U004199
database_cross_reference: LCH_NW:sh85116850
database_cross_reference: LNC:LP20777-6
database_cross_reference: MEDCIN:41199
database_cross_reference: MMSL:5476
database_cross_reference: MMSL:6383
database_cross_reference: MMSL:d00438
database_cross_reference: MSH:D012965
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:451W47IQ8X
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C29974
database_cross_reference: NCI_DCP:00250
database_cross_reference: NCI_DTP:NSC0077364
database_cross_reference: NCI_FDA:451W47IQ8X
database_cross_reference: NDDF:000759
database_cross_reference: NDDF:002238
database_cross_reference: NDFRT:N0000007207
database_cross_reference: NDFRT:N0000145832
database_cross_reference: RCD:Xa6Yy
database_cross_reference: RCD:kb5..
database_cross_reference: RCD:lA1..
database_cross_reference: RCD:le7..
database_cross_reference: RCD:mif..
database_cross_reference: RCD:x00Ar
database_cross_reference: RXNORM:9863
database_cross_reference: SNM:E-8727
database_cross_reference: SNMI:C-71070
database_cross_reference: SNOMEDCT_US:297161004
database_cross_reference: SNOMEDCT_US:330828009
database_cross_reference: SNOMEDCT_US:331125002
database_cross_reference: SNOMEDCT_US:331317007
database_cross_reference: SNOMEDCT_US:333350000
database_cross_reference: SNOMEDCT_US:387390002
database_cross_reference: SNOMEDCT_US:70379000
database_cross_reference: USPMG:MTHU001772
database_cross_reference: VANDF:4017444

Magnesium Chloride
type: Class
subclass of: Magnesium Compounds
MCID: MC00007822
PMOID: PMO:00015532
Subclass_of: Magnesium Compounds
Synonym: 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose
Synonym: 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix
Synonym: 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex
Synonym: 2.75% Travas. Amino Acid InJ.W.elecw.25%dex
Synonym: 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix
Synonym: 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix
Synonym: 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.
Synonym: 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose
Synonym: 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose
Synonym: 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix
Tree Number: T6.1.28.5
database_cross_reference: ATC:A12CC01
database_cross_reference: ATC:B05XA11
database_cross_reference: CHV:0000007661
database_cross_reference: DRUGBANK:DB09407
database_cross_reference: LCH_NW:sh2009007663
database_cross_reference: MEDCIN:198462
database_cross_reference: MEDCIN:199993
database_cross_reference: MMSL:5007
database_cross_reference: MMSL:5009
database_cross_reference: MMSL:71973
database_cross_reference: MMSL:d03796
database_cross_reference: MSH:D015636
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:02F3473H9O
database_cross_reference: NCI:C29240
database_cross_reference: NCI_DCP:01548
database_cross_reference: NCI_FDA:02F3473H9O
database_cross_reference: NDDF:000786
database_cross_reference: NDFRT:N0000007198
database_cross_reference: NDFRT:N0000146546
database_cross_reference: RXNORM:6579
database_cross_reference: SNMI:C-14815
database_cross_reference: SNOMEDCT_US:45733002
database_cross_reference: USPMG:MTHU001747
database_cross_reference: VANDF:4018213

Lithium Chloride
type: Class
subclass of: Lithium Compounds
MCID: MC00030391
PMOID: PMO:00015533
Subclass_of: Lithium Compounds
Synonym: Chloride, Lithium
Synonym: LITHIUM CHLORIDE
Synonym: Lithium Chloride [Chemical/Ingredient]
Synonym: Lithium chloride
Synonym: Lithium chloride (LiCl)
Synonym: Lithium chloride (substance)
Synonym: Lithium chloride agent
Synonym: Lithium chloride preparation
Synonym: lithium chloride
Tree Number: T6.1.44.2
database_cross_reference: CHV:0000014306
database_cross_reference: LCH_NW:sh85077583
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D018021
database_cross_reference: MTHSPL:G4962QA067
database_cross_reference: NDDF:016804
database_cross_reference: NDFRT:N0000166288
database_cross_reference: RXNORM:1311533
database_cross_reference: SNM:E-7960
database_cross_reference: SNMI:C-62150
database_cross_reference: SNOMEDCT_US:54835003

Cadmium Chloride
type: Class
subclass of: Cadmium Compounds
MCID: MC00022134
PMOID: PMO:00015534
Subclass_of: Cadmium Compounds
Synonym: CADMIUM CHLORIDE
Synonym: Cadmium Chloride [Chemical/Ingredient]
Synonym: Cadmium Dichloride
Synonym: Cadmium chloride
Synonym: Cadmium chloride (CdCl2)
Synonym: Cadmium chloride (in water)
Synonym: Cadmium chloride (in water) (product)
Synonym: Cadmium chloride (in water) (substance)
Synonym: Cadmium chloride (substance)
Synonym: CdCl2
Tree Number: T6.1.47.1
database_cross_reference: MSH:D019256
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:J6K4F9V3BA
database_cross_reference: NCI:C45894
database_cross_reference: NCI_DCP:00581
database_cross_reference: NCI_FDA:J6K4F9V3BA
database_cross_reference: NDFRT:N0000166287
database_cross_reference: RCD:X79HX
database_cross_reference: RCD:Xa4gg
database_cross_reference: RXNORM:1863268
database_cross_reference: SNOMEDCT_US:255981005
database_cross_reference: SNOMEDCT_US:290010009
database_cross_reference: SNOMEDCT_US:411323007

Ruthenium Red
type: Class
subclass of: Chlorine Compounds
subclass of: Nitrogen Compounds
subclass of: Ruthenium Compounds
MCID: MC00011531
PMOID: PMO:00015535
Subclass_of: Chlorine Compounds
Subclass_of: Nitrogen Compounds
Subclass_of: Ruthenium Compounds
Synonym: Ammoniated Ruthenium Oxychloride
Synonym: Oxychloride, Ammoniated Ruthenium
Synonym: Red, Ruthenium
Synonym: Ruthenium Oxychloride, Ammoniated
Synonym: Ruthenium Red [Chemical/Ingredient]
Synonym: Ruthenium red
Tree Number: T6.1.20.7
Tree Number: T6.1.33.8
Tree Number: T6.1.43.1
database_cross_reference: MSH:D012430
database_cross_reference: NDFRT:N0000166290

Aluminum Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067288
PMOID: PMO:00015536
Subclass_of: Inorganic Chemicals
Synonym: ALUMINUM CPDS
Synonym: Aluminium compound
Synonym: Aluminum Compounds [Chemical/Ingredient]
Synonym: Aluminum compound
Synonym: Aluminum compound (substance)
Synonym: Aluminum compound [dup] (substance)
Synonym: Aluminum compound, NOS
Synonym: Aluminum compounds
Synonym: Compounds, Aluminum
Tree Number: T6.1.21
database_cross_reference: LCH_NW:sh85004000
database_cross_reference: MSH:D017607
database_cross_reference: NDFRT:N0000007796
database_cross_reference: SNMI:C-12010
database_cross_reference: SNOMEDCT_US:276173001
database_cross_reference: SNOMEDCT_US:41433005

Chromium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067289
PMOID: PMO:00015537
Subclass_of: Inorganic Chemicals
Synonym: CHROMIUM CPDS
Synonym: Chromium Compounds [Chemical/Ingredient]
Synonym: Chromium compound
Synonym: Chromium compound (substance)
Synonym: Chromium compound, NOS
Synonym: Chromium compounds
Synonym: Compounds, Chromium
Tree Number: T6.1.22
database_cross_reference: LCH_NW:sh85025359
database_cross_reference: MSH:D017608
database_cross_reference: NDFRT:N0000007797
database_cross_reference: SNMI:C-12910
database_cross_reference: SNOMEDCT_US:34865002

Potassium Dichromate
type: Class
subclass of: Chromates
subclass of: Potassium Compounds
MCID: MC00010526
PMOID: PMO:00015538
Subclass_of: Chromates
Subclass_of: Potassium Compounds
Synonym: Bichromate, Potassium
Synonym: Chromic acid (H2Cr2O7), dipotassium salt
Synonym: Dichromate, Potassium
Synonym: K2Cr2O7
Synonym: POTASSIUM DICHROMATE
Synonym: Potassium Bichromate
Synonym: Potassium Dichromate [Chemical/Ingredient]
Synonym: Potassium dichromate
Synonym: Potassium dichromate (product)
Synonym: Potassium dichromate (substance)
Tree Number: T6.1.22.1.1
Tree Number: T6.1.34.3
database_cross_reference: CHV:0000010008
database_cross_reference: LCH:U003785
database_cross_reference: LCH_NW:sh85105608
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D011192
database_cross_reference: MTHSPL:T4423S18FM
database_cross_reference: NCI:C45890
database_cross_reference: NCI_FDA:T4423S18FM
database_cross_reference: NDDF:008993
database_cross_reference: NDFRT:N0000166188
database_cross_reference: NDFRT:N0000176046
database_cross_reference: RCD:X79Dh
database_cross_reference: RXNORM:8595
database_cross_reference: SNM:E-5202
database_cross_reference: SNMI:C-13518
database_cross_reference: SNOMEDCT_US:19893005
database_cross_reference: SNOMEDCT_US:411143006
database_cross_reference: VANDF:4025491

Barium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067290
PMOID: PMO:00015539
Subclass_of: Inorganic Chemicals
Synonym: BARIUM CPDS
Synonym: Barium Compounds [Chemical/Ingredient]
Synonym: Barium compound
Synonym: Barium compound (substance)
Synonym: Barium compound, NOS
Synonym: Barium compounds
Synonym: Compounds, Barium
Tree Number: T6.1.23
database_cross_reference: LCH_NW:sh85011856
database_cross_reference: MSH:D017609
database_cross_reference: NDFRT:N0000007799
database_cross_reference: SNMI:C-12210
database_cross_reference: SNOMEDCT_US:56958004

Calcium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067291
PMOID: PMO:00015540
Subclass_of: Inorganic Chemicals
Synonym: CALCIUM CPDS
Synonym: Calcium Compounds [Chemical/Ingredient]
Synonym: Calcium Compounds, Inorganic
Synonym: Calcium compounds
Synonym: Compounds, Calcium
Tree Number: T6.1.24
database_cross_reference: LCH_NW:sh2001000783
database_cross_reference: MSH:D017610
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007800

Calcium Fluoride
type: Class
subclass of: Calcium Compounds
MCID: MC00002116
PMOID: PMO:00015541
Subclass_of: Calcium Compounds
Synonym: CALCIUM FLUORIDE
Synonym: Calcium Fluoride [Chemical/Ingredient]
Synonym: Calcium fluoride
Synonym: Calcium fluoride (CaF2)
Synonym: Fluoride, Calcium
Synonym: calcium fluoride
Synonym: fluoride + calcium
Synonym: fluoride + calcium (medication)
Synonym: fluoride calcium
Tree Number: T6.1.24.3
database_cross_reference: CHV:0000002299
database_cross_reference: LCH_NW:sh2001000599
database_cross_reference: MEDCIN:199202
database_cross_reference: MSH:D002124
database_cross_reference: MTHSPL:O3B55K4YKI
database_cross_reference: NDDF:003792
database_cross_reference: NDFRT:N0000166213
database_cross_reference: RXNORM:1905

Calcium, Dietary
type: Class
subclass of: Calcium Compounds
MCID: MC00002139
PMOID: PMO:00015542
Subclass_of: Calcium Compounds
Synonym: Calcium
Synonym: Calcium, Dietary [Chemical/Ingredient]
Synonym: Dietary Calcium
Synonym: calcium dietary
Synonym: dietary calcium
Tree Number: T6.1.24.7
database_cross_reference: CHV:0000002311
database_cross_reference: CSP:2116-5595
database_cross_reference: MEDLINEPLUS:2780
database_cross_reference: MSH:D002136
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C68241
database_cross_reference: NCI_CRCH:C68241
database_cross_reference: NDFRT:N0000166214

Calcium Citrate
type: Class
subclass of: Calcium Compounds
MCID: MC00048248
PMOID: PMO:00015543
Subclass_of: Calcium Compounds
Synonym: 2-Hydroxy-1,2,3-propanetricarboxylic Acid, Calcium Salt (2:3)
Synonym: CALCIT
Synonym: CALCIUM (AS CITRATE)
Synonym: CALCIUM CITRATE
Synonym: Calcium Citrate Tab 350mg
Synonym: Calcium Citrate W Vitamin D Tab
Synonym: Calcium Citrate [Chemical/Ingredient]
Synonym: Calcium Citrates
Synonym: Calcium citrate
Synonym: Calcium citrate (substance)
Tree Number: T6.1.24.8
database_cross_reference: ATC:A12AA13
database_cross_reference: CHV:0000016179
database_cross_reference: DRUGBANK:DB01373
database_cross_reference: DRUGBANK:DB11093
database_cross_reference: MEDCIN:133276
database_cross_reference: MMSL:16535
database_cross_reference: MMSL:4334
database_cross_reference: MMSL:6782
database_cross_reference: MMSL:d03866
database_cross_reference: MSH:D019355
database_cross_reference: MTHSPL:MLM29U2X85
database_cross_reference: NCI:C1355
database_cross_reference: NCI_DCP:20119
database_cross_reference: NCI_FDA:MLM29U2X85
database_cross_reference: NDDF:003645
database_cross_reference: NDFRT:N0000006567
database_cross_reference: NDFRT:N0000147599
database_cross_reference: NDFRT:N0000147604
database_cross_reference: PDQ:CDR0000041817
database_cross_reference: RXNORM:47613
database_cross_reference: SNMI:C-71012
database_cross_reference: SNOMEDCT_US:52209008
database_cross_reference: VANDF:4019479
database_cross_reference: VANDF:4019484

Fluorine Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067292
PMOID: PMO:00015544
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Fluorine
Synonym: FLUORINE CPDS
Synonym: Fluorine Compounds [Chemical/Ingredient]
Synonym: Fluorine compound
Synonym: Fluorine compound (substance)
Synonym: Fluorine compound, NOS
Synonym: Fluorine compounds
Tree Number: T6.1.25
database_cross_reference: LCH:U005561
database_cross_reference: LCH_NW:sh85049431
database_cross_reference: MSH:D017611
database_cross_reference: NDFRT:N0000007801
database_cross_reference: SNMI:C-11110
database_cross_reference: SNOMEDCT_US:29183001

Fluorides, Topical
type: Class
subclass of: PMO:00024406
MCID: MC00005193
PMOID: PMO:00015545
Subclass_of: Cariostatic Agents
Synonym: Fluorides, Topical [Chemical/Ingredient]
Synonym: Topical Fluorides
Synonym: fluoride topical
Synonym: fluorides topical
Synonym: topical fluoride
Synonym: topical fluorides
Tree Number: T6.14.4.2
database_cross_reference: CHV:0000005121
database_cross_reference: MMSL:d04397
database_cross_reference: MSH:D005460
database_cross_reference: NDFRT:N0000171566

Sodium Fluoride
type: Class
subclass of: Sodium Compounds
subclass of: PMO:00024406
MCID: MC00011983
PMOID: PMO:00015546
Subclass_of: Cariostatic Agents
Subclass_of: Sodium Compounds
Synonym: 0.2% Sodium Fluoride Weekly Oral Rinse
Synonym: 1.1% Neutral Sodium Fluoride Topical Gel
Synonym: 2080 K Ginger Mint
Synonym: 2080 K Herbal Mint
Synonym: 2080 K Original
Synonym: 60 Second Gel Bubblegum
Synonym: 60 Second Gel Grape
Synonym: 60 Second Gel Mint
Synonym: 60 Second Gel Orange Cream
Synonym: 60 Second Gel Strawberry
Tree Number: T6.1.31.3
Tree Number: T6.14.4.3
database_cross_reference: AOD:0000019581
database_cross_reference: ATC:A01AA01
database_cross_reference: ATC:A12CD01
database_cross_reference: CHV:0000011488
database_cross_reference: DRUGBANK:DB09325
database_cross_reference: LCH:U004375
database_cross_reference: LCH_NW:sh85124263
database_cross_reference: MEDCIN:199669
database_cross_reference: MEDCIN:41201
database_cross_reference: MMSL:1752
database_cross_reference: MMSL:4742
database_cross_reference: MMSL:5482
database_cross_reference: MSH:D012969
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:8ZYQ1474W7
database_cross_reference: NCI:C832
database_cross_reference: NCI_DCP:00026
database_cross_reference: NCI_DTP:NSC0077385
database_cross_reference: NCI_FDA:8ZYQ1474W7
database_cross_reference: NDDF:001103
database_cross_reference: NDFRT:N0000007218
database_cross_reference: NDFRT:N0000146026
database_cross_reference: NDFRT:N0000146042
database_cross_reference: NDFRT:N0000148121
database_cross_reference: PDQ:CDR0000039598
database_cross_reference: RCD:ik1..
database_cross_reference: RXNORM:9873
database_cross_reference: SNM:E-8983
database_cross_reference: SNMI:C-15523
database_cross_reference: SNOMEDCT_US:329199009
database_cross_reference: SNOMEDCT_US:6910009
database_cross_reference: USPMG:MTHU001739
database_cross_reference: VANDF:4017647
database_cross_reference: VANDF:4017665
database_cross_reference: VANDF:4020179

Tin Fluorides
type: Class
subclass of: Tin Compounds
subclass of: PMO:00024406
MCID: MC00012868
PMOID: PMO:00015547
Subclass_of: Cariostatic Agents
Subclass_of: Tin Compounds
Synonym: Fluoride, Tin
Synonym: Fluorides, Tin
Synonym: Tin Fluoride
Synonym: Tin Fluorides [Chemical/Ingredient]
Tree Number: T6.1.40.1
Tree Number: T6.14.4.4
database_cross_reference: MSH:D014002
database_cross_reference: NDFRT:N0000005779

Gold Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067293
PMOID: PMO:00015548
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Gold
Synonym: GOLD CPDS
Synonym: Gold Compounds [Chemical/Ingredient]
Synonym: Gold compound
Synonym: Gold compound (substance)
Synonym: Gold compound, NOS
Synonym: Gold compounds
Synonym: gold compound
Synonym: gold compounds
Tree Number: T6.1.26
database_cross_reference: CHV:0000020809
database_cross_reference: LCH_NW:sh85055716
database_cross_reference: MSH:D017612
database_cross_reference: NDFRT:N0000166158
database_cross_reference: SNMI:C-14610
database_cross_reference: SNOMEDCT_US:90618003

Gold Colloid
type: Class
subclass of: Gold Compounds
MCID: MC00003098
PMOID: PMO:00015549
Subclass_of: Gold Compounds
Synonym: Colloid, Gold
Synonym: Colloidal Gold
Synonym: Colloidal gold
Synonym: Gold Colloid [Chemical/Ingredient]
Synonym: Gold, Colloidal
Synonym: colloidal gold
Tree Number: T6.1.26.3
database_cross_reference: CHV:0000003165
database_cross_reference: LCH_NW:sh88004931
database_cross_reference: MSH:D017979
database_cross_reference: NDFRT:N0000166159

Iodine Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067294
PMOID: PMO:00015550
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Iodine
Synonym: IODINE CPDS
Synonym: Iodine Compounds [Chemical/Ingredient]
Synonym: Iodine compound
Synonym: Iodine compound (substance)
Synonym: Iodine compound, NOS
Synonym: Iodine compounds
Synonym: Iodine compounds (product)
Synonym: Iodine compounds (substance)
Synonym: iodine compounds
Tree Number: T6.1.27
database_cross_reference: AOD:0000019595
database_cross_reference: LCH:U005701
database_cross_reference: LCH_NW:sh85067777
database_cross_reference: MSH:D017613
database_cross_reference: NDFRT:N0000007802
database_cross_reference: RCD:mic..
database_cross_reference: SNMI:C-11410
database_cross_reference: SNOMEDCT_US:333308000
database_cross_reference: SNOMEDCT_US:57272005

Potassium Iodide
type: Class
subclass of: Iodides
subclass of: Potassium Compounds
MCID: MC00010528
PMOID: PMO:00015551
Subclass_of: Iodides
Subclass_of: Potassium Compounds
Synonym: Antistrumin
Synonym: Central-vite 18 Essential
Synonym: Century Complete
Synonym: Complete Multivitamins and Minerals Tablets Timed Release
Synonym: Diodine
Synonym: Foltabs Prenatal
Synonym: Formula Fe-vitamin and Mineral Tab
Synonym: Fusion Activator Formula Tab
Synonym: HUMCO Strong Iodine Solution
Synonym: Hemarexin Tab
Tree Number: T6.1.27.2.1
Tree Number: T6.1.34.4
database_cross_reference: AOD:0000019586
database_cross_reference: ATC:R05CA02
database_cross_reference: ATC:S01XA04
database_cross_reference: ATC:V03AB21
database_cross_reference: CHV:0000010009
database_cross_reference: DRUGBANK:DB06715
database_cross_reference: LCH:U003786
database_cross_reference: LCH_NW:sh85105614
database_cross_reference: MEDCIN:199207
database_cross_reference: MMSL:1847
database_cross_reference: MMSL:5333
database_cross_reference: MMSL:d00800
database_cross_reference: MSH:D011193
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:1C4QK22F9J
database_cross_reference: NCI:C47680
database_cross_reference: NCI_DCP:00932
database_cross_reference: NCI_FDA:1C4QK22F9J
database_cross_reference: NDDF:000734
database_cross_reference: NDDF:000846
database_cross_reference: NDDF:003151
database_cross_reference: NDDF:007600
database_cross_reference: NDFRT:N0000005866
database_cross_reference: NDFRT:N0000146024
database_cross_reference: NDFRT:N0000146052
database_cross_reference: RXNORM:8597
database_cross_reference: SNM:E-8951
database_cross_reference: SNMI:C-88340
database_cross_reference: SNOMEDCT_US:400389005
database_cross_reference: SNOMEDCT_US:89351005
database_cross_reference: VANDF:4017645
database_cross_reference: VANDF:4017676

Sodium Iodide
type: Class
subclass of: Iodides
subclass of: Sodium Compounds
MCID: MC00011994
PMOID: PMO:00015552
Subclass_of: Iodides
Subclass_of: Sodium Compounds
Synonym: IODIDE (AS SODIUM IODIDE)
Synonym: SODIUM IODIDE
Synonym: Sodium Iodide [Chemical/Ingredient]
Synonym: Sodium iodide
Synonym: Sodium iodide (NaI)
Synonym: Sodium iodide (substance)
Synonym: iodide sodium
Synonym: sodium iodide
Synonym: sodium iodide (medication)
Tree Number: T6.1.27.2.2
Tree Number: T6.1.31.7
database_cross_reference: AOD:0000019583
database_cross_reference: CHV:0000011494
database_cross_reference: DRUGBANK:DB11119
database_cross_reference: LCH_NW:sh88002051
database_cross_reference: MEDCIN:199208
database_cross_reference: MMSL:5486
database_cross_reference: MMSL:72100
database_cross_reference: MMSL:d03721
database_cross_reference: MSH:D012974
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:F5WR8N145C
database_cross_reference: NCI:C80943
database_cross_reference: NCI_FDA:F5WR8N145C
database_cross_reference: NDDF:000850
database_cross_reference: NDDF:003671
database_cross_reference: NDFRT:N0000007240
database_cross_reference: NDFRT:N0000145855
database_cross_reference: NDFRT:N0000147314
database_cross_reference: RXNORM:9884
database_cross_reference: SNM:E-8952
database_cross_reference: SNMI:C-88385
database_cross_reference: SNOMEDCT_US:62754006
database_cross_reference: VANDF:4017467
database_cross_reference: VANDF:4019045

Iodophors
type: Class
subclass of: Iodine Compounds
MCID: MC00007005
PMOID: PMO:00015553
Subclass_of: Iodine Compounds
Synonym: Iodine, Tamed
Synonym: Iodophors [Chemical/Ingredient]
Synonym: Tamed Iodine
Synonym: iodophor
Synonym: iodophors
Tree Number: T6.1.27.3
database_cross_reference: CHV:0000006902
database_cross_reference: LCH_NW:sh2013000291
database_cross_reference: MSH:D007466
database_cross_reference: NDFRT:N0000175091
database_cross_reference: RXNORM:596712

Povidone-Iodine
type: Class
subclass of: Iodophors
MCID: MC00010539
PMOID: PMO:00015554
Subclass_of: Iodophors
Synonym: 2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine
Synonym: 3-Step First Aid Kit
Synonym: AMSure Three Povidone-Iodine Swabsticks
Synonym: Acu Dyne Ointment
Synonym: Acu Dyne Prep Soln Liq
Synonym: Acu Dyne Skin Cleanser
Synonym: Acu Dyne Swab Stick
Synonym: Acudyne Prep Solution
Synonym: Acudyne Prep Swab F420
Synonym: Alphadine Solution 10%
Tree Number: T6.1.27.3.1
database_cross_reference: ATC:D08AG02
database_cross_reference: ATC:D09AA09
database_cross_reference: ATC:D11AC06
database_cross_reference: ATC:G01AX11
database_cross_reference: ATC:R02AA15
database_cross_reference: ATC:S01AX18
database_cross_reference: CHV:0000010018
database_cross_reference: DRUGBANK:DB05382
database_cross_reference: DRUGBANK:DB06812
database_cross_reference: LCH:U003793
database_cross_reference: LCH_NW:sh85105954
database_cross_reference: MEDCIN:40738
database_cross_reference: MMSL:1871
database_cross_reference: MMSL:5338
database_cross_reference: MSH:D011206
database_cross_reference: MTHSPL:85H0HZU99M
database_cross_reference: NCI:C766
database_cross_reference: NCI_DTP:NSC0026245
database_cross_reference: NCI_FDA:85H0HZU99M
database_cross_reference: NDDF:003153
database_cross_reference: NDFRT:N0000006587
database_cross_reference: NDFRT:N0000146508
database_cross_reference: NDFRT:N0000147472
database_cross_reference: PDQ:CDR0000039166
database_cross_reference: RCD:g62..
database_cross_reference: RCD:le6..
database_cross_reference: RCD:x02MD
database_cross_reference: RCDAE:g62..
database_cross_reference: RXNORM:8611
database_cross_reference: SNM:E-7141
database_cross_reference: SNMI:C-902CF
database_cross_reference: SNOMEDCT_US:111144003
database_cross_reference: SNOMEDCT_US:326293001
database_cross_reference: SNOMEDCT_US:331314000
database_cross_reference: SNOMEDCT_US:386989006
database_cross_reference: VANDF:4018171
database_cross_reference: VANDF:4019273

Magnesium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067295
PMOID: PMO:00015555
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Magnesium
Synonym: MAGNESIUM CPDS
Synonym: Magnesium Compounds [Chemical/Ingredient]
Synonym: Magnesium Compounds, Inorganic
Synonym: Magnesium compounds
Synonym: inorganic magnesium compounds
Tree Number: T6.1.28
database_cross_reference: AOD:0000019587
database_cross_reference: LCH_NW:sh90000932
database_cross_reference: MSH:D017616
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007803

Silicon Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067307
PMOID: PMO:00015556
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Silicon
Synonym: SILICON CPDS
Synonym: Silicon Compounds [Chemical/Ingredient]
Synonym: Silicon Compounds, Inorganic
Synonym: Silicon compounds
Tree Number: T6.1.29
database_cross_reference: LCH:U006143
database_cross_reference: LCH_NW:sh85122521
database_cross_reference: MSH:D017655
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007828

Silanes
type: Class
subclass of: Silicon Compounds
subclass of: Organosilicon Compounds
MCID: MC00011856
PMOID: PMO:00015557
Subclass_of: Organosilicon Compounds
Subclass_of: Silicon Compounds
Synonym: Silanes [Chemical/Ingredient]
Tree Number: T6.1.29.1
Tree Number: T6.2.36.1
database_cross_reference: MSH:D012821
database_cross_reference: NDFRT:N0000166554

Silica Gel
type: Class
subclass of: PMO:00024215
MCID: MC00797883
PMOID: PMO:00015558
Subclass_of: Gels
Synonym: 2080 Dentistry Night Fresh
Synonym: 2080 Dentistry Night Repair
Synonym: Calcium With Mg Zn Mn Cu CR Si and Vit. C & D
Synonym: Calcium and Magnesium 1:1 Plus Tablets
Synonym: Calcor
Synonym: Calplus
Synonym: Chunzam Silk Amino Acid Tooth
Synonym: Colgate Total Advanced Health Daily Repair
Synonym: Colgate Total Advanced Health Sensitive
Synonym: DIO Enamel Coating Pen Pro Tooth
Tree Number: T6.12.3.3.2
database_cross_reference: CHV:0000014810
database_cross_reference: DRUGBANK:DB11132
database_cross_reference: LCH_NW:sh85122499
database_cross_reference: MDDB:06693
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D058428
database_cross_reference: NDFRT:N0000022948
database_cross_reference: NDFRT:N0000182101
database_cross_reference: VANDF:4020878

Siloxanes
type: Class
subclass of: Silicon Compounds
subclass of: Organosilicon Compounds
subclass of: Polymers
MCID: MC00011869
PMOID: PMO:00015559
Subclass_of: Organosilicon Compounds
Subclass_of: Polymers
Subclass_of: Silicon Compounds
Synonym: Polysiloxane
Synonym: Polysiloxanes
Synonym: Siloxane
Synonym: Siloxanes [Chemical/Ingredient]
Synonym: polysiloxane
Synonym: siloxane
Tree Number: T6.1.29.3
Tree Number: T6.14.9.13
Tree Number: T6.2.36.2
Tree Number: T6.5.2.15
database_cross_reference: CHV:0000011350
database_cross_reference: CSP:4000-0332
database_cross_reference: LCH:U004320
database_cross_reference: LCH_NW:sh85122576
database_cross_reference: MSH:D012833
database_cross_reference: NDFRT:N0000007600

Mercury Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067311
PMOID: PMO:00015560
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Mercury
Synonym: Inorganic mercury compound
Synonym: Inorganic mercury compound (substance)
Synonym: MERCURY CPDS
Synonym: Mercury Compounds [Chemical/Ingredient]
Synonym: Mercury Compounds, Inorganic
Synonym: Mercury compounds
Tree Number: T6.1.30
database_cross_reference: LCH:U005765
database_cross_reference: LCH_NW:sh85083809
database_cross_reference: MSH:D017669
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007831
database_cross_reference: RCD:XaD1o
database_cross_reference: SNOMEDCT_US:311748008

Sodium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067312
PMOID: PMO:00015561
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Sodium
Synonym: SODIUM CPDS
Synonym: Sodium Compounds [Chemical/Ingredient]
Synonym: Sodium Compounds, Inorganic
Synonym: Sodium compounds
Synonym: inorganic sodium compounds
Tree Number: T6.1.31
database_cross_reference: AOD:0000019574
database_cross_reference: LCH_NW:sh85124260
database_cross_reference: MSH:D017670
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007844

Sodium Chloride, Dietary
type: Class
subclass of: Sodium Chloride
subclass of: Sodium, Dietary
PMOID: PMO:00015562
Subclass_of: Sodium Chloride
Subclass_of: Sodium, Dietary
Tree Number: T6.1.31.1.1
Tree Number: T6.1.31.9.1

Sodium Cyanide
type: Class
subclass of: Sodium Compounds
MCID: MC00011975
PMOID: PMO:00015563
Subclass_of: Sodium Compounds
Synonym: Cyanide, Sodium
Synonym: Sodium Cyanide [Chemical/Ingredient]
Synonym: Sodium cyanide
Synonym: Sodium cyanide (Na(CN))
Synonym: Sodium cyanide (substance)
Synonym: sodium cyanide
Tree Number: T6.1.31.2
database_cross_reference: CHV:0000011484
database_cross_reference: LCH_NW:sh2006001698
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D012966
database_cross_reference: NDFRT:N0000166184
database_cross_reference: RCD:XaD13
database_cross_reference: SNM:E-5245
database_cross_reference: SNMI:C-15511
database_cross_reference: SNOMEDCT_US:84144005

Sodium Nitrite
type: Class
subclass of: Sodium Compounds
MCID: MC00012003
PMOID: PMO:00015564
Subclass_of: Sodium Compounds
Synonym: Nitrite, Sodium
Synonym: Nitrous acid, sodium salt
Synonym: SODIUM NITRITE
Synonym: Sodium Nitrite Injection, USP
Synonym: Sodium Nitrite [Chemical/Ingredient]
Synonym: Sodium nitrite
Synonym: Sodium nitrite (substance)
Synonym: Sodium nitrite product
Synonym: Sodium nitrite product (product)
Synonym: Sodium nitrite product (substance)
Tree Number: T6.1.31.8
database_cross_reference: AOD:0000019618
database_cross_reference: ATC:V03AB08
database_cross_reference: CHV:0000011497
database_cross_reference: DRUGBANK:DB09112
database_cross_reference: LNC:LP62282-6
database_cross_reference: MMSL:47919
database_cross_reference: MMSL:5488
database_cross_reference: MMSL:d04086
database_cross_reference: MSH:D012977
database_cross_reference: MTHSPL:M0KG633D4F
database_cross_reference: NDDF:000682
database_cross_reference: NDFRT:N0000007245
database_cross_reference: NDFRT:N0000145900
database_cross_reference: RCD:Ub0e1
database_cross_reference: RCD:as2..
database_cross_reference: RXNORM:9894
database_cross_reference: SNM:E-7705
database_cross_reference: SNMI:C-81625
database_cross_reference: SNOMEDCT_US:10377000
database_cross_reference: SNOMEDCT_US:228101007
database_cross_reference: SNOMEDCT_US:317873006
database_cross_reference: VANDF:4017515

Sodium, Dietary
type: Class
subclass of: Sodium Compounds
PMOID: PMO:00015565
Subclass_of: Sodium Compounds
Tree Number: T6.1.31.9

Sodium Selenite
type: Class
subclass of: Sodium Compounds
subclass of: Selenious Acid
MCID: MC00056144
PMOID: PMO:00015566
Subclass_of: Selenious Acid
Subclass_of: Sodium Compounds
Synonym: Disodium Selenite
Synonym: Disodium Selenium Trioxide
Synonym: SODIUM SELENITE
Synonym: Selenious Acid Disodium Salt
Synonym: Selenious Acid, Sodium Salt (1:2)
Synonym: Selenious acid, disodium salt
Synonym: Selenite, Disodium
Synonym: Selenite, Sodium
Synonym: Selenous Acid Disodium Salt
Synonym: Selenous Acid, Disodium Salt
Tree Number: T6.1.31.11
Tree Number: T6.1.46.1.1
database_cross_reference: ATC:A12CE02
database_cross_reference: CHV:0000016510
database_cross_reference: MEDCIN:250041
database_cross_reference: MSH:D018038
database_cross_reference: MTHSPL:HIW548RQ3W
database_cross_reference: NCI:C87346
database_cross_reference: NCI_FDA:HIW548RQ3W
database_cross_reference: NDDF:005523
database_cross_reference: NDDF:011642
database_cross_reference: NDFRT:N0000006253
database_cross_reference: NDFRT:N0000148373
database_cross_reference: RXNORM:56519
database_cross_reference: SNMI:C-71091
database_cross_reference: SNOMEDCT_US:96277001
database_cross_reference: VANDF:4020869

Sodium Azide
type: Class
subclass of: Sodium Compounds
subclass of: Azides
MCID: MC00037868
PMOID: PMO:00015567
Subclass_of: Azides
Subclass_of: Sodium Compounds
Synonym: Azide, Sodium
Synonym: NAN 003
Synonym: NaN3
Synonym: Sodium Azide [Chemical/Ingredient]
Synonym: Sodium azide
Synonym: Sodium azide (substance)
Synonym: sodium azide
Tree Number: T6.1.31.12
Tree Number: T6.1.33.2.1
database_cross_reference: CHV:0000014822
database_cross_reference: MSH:D019810
database_cross_reference: NDFRT:N0000166185
database_cross_reference: SNOMEDCT_US:6261000124101

Platinum Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067313
PMOID: PMO:00015568
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Inorganic Platinum
Synonym: Compounds, Platinum
Synonym: Inorganic Platinum Compounds
Synonym: PLATINUM CPDS
Synonym: PLATINUM CPDS INORGANIC
Synonym: Platinum Compounds [Chemical/Ingredient]
Synonym: Platinum Compounds, Inorganic
Synonym: Platinum compounds
Tree Number: T6.1.32
database_cross_reference: LCH_NW:sh85103311
database_cross_reference: MSH:D017671
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007845

Nitrogen Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00008937
PMOID: PMO:00015569
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Nitrogen
Synonym: NITROGEN CPDS
Synonym: Nitrogen Compounds [Chemical/Ingredient]
Synonym: Nitrogen Compounds, Inorganic
Synonym: Nitrogen compounds
Synonym: inorganic nitrogen compounds
Tree Number: T6.1.33
database_cross_reference: AOD:0000019597
database_cross_reference: LCH_NW:sh85092069
database_cross_reference: MSH:D017672
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007847

Azides
type: Class
subclass of: Nitrogen Compounds
subclass of: Organic Chemicals
MCID: MC00001439
PMOID: PMO:00015570
Subclass_of: Nitrogen Compounds
Subclass_of: Organic Chemicals
Synonym: Azides [Chemical/Ingredient]
Synonym: azide
Synonym: azides
Tree Number: T6.1.33.2
Tree Number: T6.2.9
database_cross_reference: AOD:0000020013
database_cross_reference: CHV:0000001639
database_cross_reference: CSP:0315-0386
database_cross_reference: LCH:U000460
database_cross_reference: LCH_NW:sh85010647
database_cross_reference: MSH:D001386
database_cross_reference: NDFRT:N0000011411

Cyanamide
type: Class
subclass of: Carbodiimides
MCID: MC00003384
PMOID: PMO:00015571
Subclass_of: Carbodiimides
Synonym: CYANAMIDE
Synonym: Carbimide
Synonym: Cyanamid
Synonym: Cyanamide [Chemical/Ingredient]
Synonym: carbimide
Synonym: cyanamide
Tree Number: T6.2.19.1.2
database_cross_reference: AOD:0000019602
database_cross_reference: CHV:0000003513
database_cross_reference: CSP:0113-1292
database_cross_reference: DRUGBANK:DB02679
database_cross_reference: LCH:U005421
database_cross_reference: MSH:D003484
database_cross_reference: NCI:C76744
database_cross_reference: NCI_FDA:21CP7826LC
database_cross_reference: NDDF:003954
database_cross_reference: NDFRT:N0000166163

Potassium Cyanide
type: Class
subclass of: Potassium Compounds
MCID: MC00010523
PMOID: PMO:00015572
Subclass_of: Potassium Compounds
Synonym: Cyanide, Potassium
Synonym: Kali cyanatum / potassium cyanide
Synonym: Potassium Cyanide [Chemical/Ingredient]
Synonym: Potassium cyanide
Synonym: Potassium cyanide (K(CN))
Synonym: Potassium cyanide (substance)
Synonym: kali cyanatum/potassium cyan
Tree Number: T6.1.34.2
database_cross_reference: ALT:HAKAH
database_cross_reference: LCH:U003784
database_cross_reference: LCH_NW:sh85105605
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D011190
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166187
database_cross_reference: RCD:XaD1W
database_cross_reference: SNM:E-5196
database_cross_reference: SNMI:C-13514
database_cross_reference: SNOMEDCT_US:84424008

Peroxynitrous Acid
type: Class
subclass of: Nitrous Acid
subclass of: Reactive Nitrogen Species
MCID: MC00218819
PMOID: PMO:00015573
Subclass_of: Nitrous Acid
Subclass_of: Reactive Nitrogen Species
Synonym: Acid, Peroxynitrous
Synonym: Acids, Peroxynitrous
Synonym: Peroxynitrous Acid [Chemical/Ingredient]
Synonym: Peroxynitrous Acids
Tree Number: T6.1.33.10.2
Tree Number: T6.1.33.7.2
database_cross_reference: MSH:D030421
database_cross_reference: NDFRT:N0000166165

Silver Nitrate
type: Class
subclass of: Silver Compounds
MCID: MC00011875
PMOID: PMO:00015574
Subclass_of: Silver Compounds
Synonym: AgNO3 - Silver nitrate
Synonym: Grafco Applicator 15 Cm
Synonym: Grafco Applicator 30 Cm
Synonym: Grafco Applicator 45 Cm
Synonym: Lunar caustic
Synonym: Nitric acid silver(1+) salt
Synonym: Repara Silver Nitrate Applicators
Synonym: SILVER NITRATE
Synonym: Silver Nitrate Applicators
Synonym: Silver Nitrate Ophthalmic
Tree Number: T6.1.45.1
database_cross_reference: AOD:0000019611
database_cross_reference: ATC:D08AL01
database_cross_reference: CHV:0000011353
database_cross_reference: DRUGBANK:DB11080
database_cross_reference: LCH:U004322
database_cross_reference: LCH_NW:sh85122640
database_cross_reference: MEDCIN:41335
database_cross_reference: MMSL:11553
database_cross_reference: MMSL:1644
database_cross_reference: MMSL:5461
database_cross_reference: MMSL:d01212
database_cross_reference: MSH:D012835
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:95IT3W8JZE
database_cross_reference: NCI:C77057
database_cross_reference: NCI_FDA:95IT3W8JZE
database_cross_reference: NDDF:003132
database_cross_reference: NDFRT:N0000006190
database_cross_reference: NDFRT:N0000145853
database_cross_reference: RCD:X79Hg
database_cross_reference: RCD:Xa1rr
database_cross_reference: RCD:m88..
database_cross_reference: RCD:mie..
database_cross_reference: RCD:x02Mc
database_cross_reference: RXNORM:9789
database_cross_reference: SNM:E-7143
database_cross_reference: SNMI:C-96230
database_cross_reference: SNOMEDCT_US:255985001
database_cross_reference: SNOMEDCT_US:281759006
database_cross_reference: SNOMEDCT_US:332464009
database_cross_reference: SNOMEDCT_US:333344005
database_cross_reference: SNOMEDCT_US:35476001
database_cross_reference: SNOMEDCT_US:373483000
database_cross_reference: SNOMEDCT_US:411331002
database_cross_reference: VANDF:4017465

Uranyl Nitrate
type: Class
subclass of: Uranium Compounds
MCID: MC00013336
PMOID: PMO:00015575
Subclass_of: Uranium Compounds
Synonym: Nitrate, Uranium
Synonym: Nitrate, Uranyl
Synonym: URANYL NITRATE
Synonym: Uranium Nitrate
Synonym: Uranium nitrate
Synonym: Uranium nitrate (substance)
Synonym: Uranium, bis(nitrato-O)dioxo-, (T-4)-
Synonym: Uranyl Nitrate [Chemical/Ingredient]
Synonym: Uranyl nitrate
Synonym: uranyl nitrate
Tree Number: T6.1.42.1
database_cross_reference: MSH:D014502
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:0C0WI17JYF
database_cross_reference: NDFRT:N0000166162
database_cross_reference: RXNORM:1858851
database_cross_reference: SNM:E-5211
database_cross_reference: SNMI:C-14011
database_cross_reference: SNOMEDCT_US:83963003

Reactive Nitrogen Species
type: Class
subclass of: Nitrogen Compounds
subclass of: Nitroso Compounds
MCID: MC00353510
PMOID: PMO:00015576
Subclass_of: Nitrogen Compounds
Subclass_of: Nitroso Compounds
Synonym: Nitrogen Species, Reactive
Synonym: Reactive Nitrogen Species [Chemical/Ingredient]
Synonym: Species, Reactive Nitrogen
Tree Number: T6.1.33.10
Tree Number: T6.2.26.5
database_cross_reference: MSH:D026361
database_cross_reference: NDFRT:N0000011365

Ammonium Compounds
type: Class
subclass of: Nitrogen Compounds
MCID: MC00000792
PMOID: PMO:00015577
Subclass_of: Nitrogen Compounds
Synonym: AMMONIUM CPDS
Synonym: Ammonium Compounds [Chemical/Ingredient]
Synonym: Ammonium compound
Synonym: Ammonium compound (substance)
Synonym: Ammonium compound, NOS
Synonym: Ammonium compounds
Synonym: ammonium compound
Tree Number: T6.1.33.11
database_cross_reference: CSP:0156-5828
database_cross_reference: LCH:U000205
database_cross_reference: LCH_NW:sh85004547
database_cross_reference: MSH:D064751
database_cross_reference: NDFRT:N0000189391
database_cross_reference: SNMI:C-10760
database_cross_reference: SNOMEDCT_US:6999006

Quaternary Ammonium Compounds
type: Class
subclass of: Ammonium Compounds
subclass of: Amines
subclass of: Onium Compounds
MCID: MC00177868
PMOID: PMO:00015578
Subclass_of: Amines
Subclass_of: Ammonium Compounds
Subclass_of: Onium Compounds
Synonym: Ammonium Compounds, Quaternary
Synonym: QUATERNARY AMMONIUM CPDS
Synonym: Quaternary Ammonium Compounds [Chemical/Ingredient]
Synonym: Quaternary ammonium compound
Synonym: Quaternary ammonium compound (substance)
Synonym: ammonium compounds quaternary
Synonym: quaternary ammonium compound
Tree Number: T6.1.33.11.2
Tree Number: T6.2.27.1
Tree Number: T6.2.6.4
database_cross_reference: CHV:0000040424
database_cross_reference: CSP:0156-8322
database_cross_reference: LNC:LP36294-4
database_cross_reference: LNC:MTHU019422
database_cross_reference: MSH:D000644
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166489
database_cross_reference: RCD:Xa83n
database_cross_reference: SNOMEDCT_US:301712000

Hydroxylamine
type: Class
subclass of: Ammonium Compounds
MCID: MC00006502
PMOID: PMO:00015579
Subclass_of: Ammonium Compounds
Synonym: Hydroxylamine (substance)
Synonym: Hydroxylamine [Chemical/Ingredient]
Synonym: hydroxylamine
Tree Number: T6.1.33.11.4
database_cross_reference: AOD:0000020130
database_cross_reference: CHV:0000006382
database_cross_reference: LCH:U002292
database_cross_reference: LCH_NW:sh85063506
database_cross_reference: MSH:D019811
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166164
database_cross_reference: SNM:E-5074
database_cross_reference: SNMI:C-21740
database_cross_reference: SNOMEDCT_US:33190009

Potassium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067316
PMOID: PMO:00015580
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Potassium
Synonym: POTASSIUM CPDS
Synonym: Potassium Compounds [Chemical/Ingredient]
Synonym: Potassium compound
Synonym: Potassium compound (substance)
Synonym: Potassium compound, NOS
Synonym: Potassium compounds
Synonym: inorganic potassium compounds
Tree Number: T6.1.34
database_cross_reference: AOD:0000019584
database_cross_reference: LCH_NW:sh85105604
database_cross_reference: MSH:D017680
database_cross_reference: NDFRT:N0000007854
database_cross_reference: SNMI:C-13510
database_cross_reference: SNOMEDCT_US:19751002

Potassium Permanganate
type: Class
subclass of: Potassium Compounds
subclass of: Manganese Compounds
MCID: MC00010534
PMOID: PMO:00015581
Subclass_of: Manganese Compounds
Subclass_of: Potassium Compounds
Synonym: Kali permanganicum / potassium permanganate
Synonym: POTASSIUM PERMANGANATE
Synonym: Permanganate, Potassium
Synonym: Permanganic acid (HMnO4), potassium salt
Synonym: Pot permang
Synonym: Potassium Permanganate [Chemical/Ingredient]
Synonym: Potassium permanganate
Synonym: Potassium permanganate (substance)
Synonym: Potassium permanganate product
Synonym: Potassium permanganate product (product)
Tree Number: T6.1.34.5
Tree Number: T6.1.36.1
database_cross_reference: ALT:HAKAO
database_cross_reference: ATC:D08AX06
database_cross_reference: ATC:V03AB18
database_cross_reference: CHV:0000010011
database_cross_reference: LCH:U003787
database_cross_reference: LCH_NW:sh85105616
database_cross_reference: MEDCIN:40100
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D011196
database_cross_reference: NCI:C76726
database_cross_reference: NCI_FDA:00OT1QX5U4
database_cross_reference: NDDF:003160
database_cross_reference: NDFRT:N0000005868
database_cross_reference: NDFRT:N0000148188
database_cross_reference: RCD:mid..
database_cross_reference: RXNORM:8604
database_cross_reference: SNM:E-7137
database_cross_reference: SNMI:C-10422
database_cross_reference: SNOMEDCT_US:333339003
database_cross_reference: SNOMEDCT_US:4681002
database_cross_reference: VANDF:4020365

Potassium, Dietary
type: Class
subclass of: Potassium Compounds
PMOID: PMO:00015582
Subclass_of: Potassium Compounds
Tree Number: T6.1.34.6

Potassium Acetate
type: Class
subclass of: Potassium Compounds
MCID: MC00054778
PMOID: PMO:00015583
Subclass_of: Potassium Compounds
Synonym: Acetate, Potassium
Synonym: Acetic Acid, Potassium Salt
Synonym: FEMA No. 2920
Synonym: POTASSIUM ACETATE
Synonym: Potassium Acetate [Chemical/Ingredient]
Synonym: Potassium Ethanoate
Synonym: Potassium acetate
Synonym: Potassium acetate (substance)
Synonym: potassium acetate
Synonym: potassium acetate (medication)
Tree Number: T6.1.34.7
database_cross_reference: ATC:B05XA17
database_cross_reference: CHV:0000016448
database_cross_reference: DRUGBANK:DB01345
database_cross_reference: MEDCIN:41251
database_cross_reference: MMSL:1780
database_cross_reference: MMSL:5322
database_cross_reference: MMSL:d03777
database_cross_reference: MSH:D019347
database_cross_reference: MTHSPL:M911911U02
database_cross_reference: NCI:C47677
database_cross_reference: NCI_FDA:M911911U02
database_cross_reference: NDDF:000764
database_cross_reference: NDFRT:N0000006530
database_cross_reference: NDFRT:N0000145902
database_cross_reference: RXNORM:54987
database_cross_reference: SNM:E-8702
database_cross_reference: SNMI:C-71061
database_cross_reference: SNOMEDCT_US:52394008
database_cross_reference: USPMG:MTHU001753
database_cross_reference: VANDF:4017517

Osmium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067389
PMOID: PMO:00015584
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Osmium
Synonym: OSMIUM CPDS
Synonym: Osmium Compounds [Chemical/Ingredient]
Synonym: Osmium compound
Synonym: Osmium compound (substance)
Synonym: Osmium compound, NOS
Synonym: Osmium compounds
Tree Number: T6.1.35
database_cross_reference: LCH_NW:sh85095931
database_cross_reference: MSH:D017892
database_cross_reference: NDFRT:N0000166215
database_cross_reference: SNMI:C-15210
database_cross_reference: SNOMEDCT_US:35747000

Manganese Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067390
PMOID: PMO:00015585
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Manganese
Synonym: MANGANESE CPDS
Synonym: Manganese Compounds [Chemical/Ingredient]
Synonym: Manganese compound
Synonym: Manganese compound (substance)
Synonym: Manganese compound, NOS
Synonym: Manganese compounds
Tree Number: T6.1.36
database_cross_reference: LCH_NW:sh85080489
database_cross_reference: MSH:D017895
database_cross_reference: NDFRT:N0000007531
database_cross_reference: SNMI:C-14910
database_cross_reference: SNOMEDCT_US:73196006

Zinc Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067401
PMOID: PMO:00015586
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Zinc
Synonym: ZINC CPDS
Synonym: Zinc Compounds [Chemical/Ingredient]
Synonym: Zinc Compounds, Inorganic
Synonym: Zinc compounds
Tree Number: T6.1.37
database_cross_reference: LCH_NW:sh85149856
database_cross_reference: MSH:D017967
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007687

Vanadium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067402
PMOID: PMO:00015587
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Vanadium
Synonym: VANADIUM CPDS
Synonym: Vanadium Compounds [Chemical/Ingredient]
Synonym: Vanadium compound
Synonym: Vanadium compound (substance)
Synonym: Vanadium compound, NOS
Synonym: Vanadium compounds
Tree Number: T6.1.38
database_cross_reference: LCH_NW:sh2008020195
database_cross_reference: MSH:D017968
database_cross_reference: NDFRT:N0000166278
database_cross_reference: SNMI:C-16510
database_cross_reference: SNOMEDCT_US:55368008

Thorium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067403
PMOID: PMO:00015588
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Thorium
Synonym: THORIUM CPDS
Synonym: Thorium Compounds [Chemical/Ingredient]
Synonym: Thorium compound
Synonym: Thorium compound (substance)
Synonym: Thorium compound, NOS
Synonym: Thorium compounds
Tree Number: T6.1.39
database_cross_reference: LCH_NW:sh2012003208
database_cross_reference: MSH:D017970
database_cross_reference: NDFRT:N0000166221
database_cross_reference: SNMI:C-15710
database_cross_reference: SNOMEDCT_US:90879003

Tin Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067404
PMOID: PMO:00015589
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Tin
Synonym: TIN CPDS
Synonym: Tin Compounds [Chemical/Ingredient]
Synonym: Tin compound
Synonym: Tin compound (substance)
Synonym: Tin compound, NOS
Synonym: Tin compounds
Tree Number: T6.1.40
database_cross_reference: LCH_NW:sh85135492
database_cross_reference: MSH:D017971
database_cross_reference: NDFRT:N0000007695
database_cross_reference: SNMI:C-13910
database_cross_reference: SNOMEDCT_US:88097006

Tungsten Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067405
PMOID: PMO:00015590
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Tungsten
Synonym: TUNGSTEN CPDS
Synonym: Tungsten Compounds [Chemical/Ingredient]
Synonym: Tungsten compound
Synonym: Tungsten compound (substance)
Synonym: Tungsten compound, NOS
Synonym: Tungsten compounds
Tree Number: T6.1.41
database_cross_reference: LCH_NW:sh85138618
database_cross_reference: MSH:D017973
database_cross_reference: NDFRT:N0000166087
database_cross_reference: SNMI:C-16410
database_cross_reference: SNOMEDCT_US:64843006

Uranium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067406
PMOID: PMO:00015591
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Uranium
Synonym: URANIUM CPDS
Synonym: Uranium Compounds [Chemical/Ingredient]
Synonym: Uranium compound
Synonym: Uranium compound (substance)
Synonym: Uranium compound, NOS
Synonym: Uranium compounds
Tree Number: T6.1.42
database_cross_reference: LCH_NW:sh85141285
database_cross_reference: MSH:D017974
database_cross_reference: NDFRT:N0000166089
database_cross_reference: SNMI:C-14010
database_cross_reference: SNOMEDCT_US:32269000

Ruthenium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067407
PMOID: PMO:00015592
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Ruthenium
Synonym: RUTHENIUM CPDS
Synonym: Ruthenium Compounds [Chemical/Ingredient]
Synonym: Ruthenium compounds
Tree Number: T6.1.43
database_cross_reference: LCH_NW:sh85116090
database_cross_reference: MSH:D017975
database_cross_reference: NDFRT:N0000166289

Lithium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067426
PMOID: PMO:00015593
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Lithium
Synonym: LITHIUM CPDS
Synonym: Lithium Compounds [Chemical/Ingredient]
Synonym: Lithium compound
Synonym: Lithium compound (substance)
Synonym: Lithium compound, NOS
Synonym: Lithium compounds
Tree Number: T6.1.44
database_cross_reference: LCH_NW:sh98005205
database_cross_reference: MSH:D018020
database_cross_reference: NDFRT:N0000007941
database_cross_reference: SNMI:C-15410
database_cross_reference: SNOMEDCT_US:36378007

Silver Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067428
PMOID: PMO:00015594
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Silver
Synonym: SILVER CPDS
Synonym: Silver Compounds [Chemical/Ingredient]
Synonym: Silver Compounds, Inorganic
Synonym: Silver compounds
Tree Number: T6.1.45
database_cross_reference: LCH_NW:sh85122611
database_cross_reference: MSH:D018030
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007942

Selenium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00067431
PMOID: PMO:00015595
Subclass_of: Inorganic Chemicals
Synonym: Compounds, Selenium
Synonym: SELENIUM CPDS
Synonym: Selenium Compound
Synonym: Selenium Compounds [Chemical/Ingredient]
Synonym: Selenium Compounds, Inorganic
Synonym: Selenium compounds
Synonym: selenium compounds
Tree Number: T6.1.46
database_cross_reference: AOD:0000019648
database_cross_reference: LCH_NW:sh85119694
database_cross_reference: MSH:D018036
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45499
database_cross_reference: NDFRT:N0000007943

Selenious Acid
type: Class
subclass of: Selenium Compounds
MCID: MC00037555
PMOID: PMO:00015596
Subclass_of: Selenium Compounds
Synonym: Acid, Selenious
Synonym: Acid, Selenous
Synonym: Hydrogen Selenite
Synonym: M.T.E.-6 Concentrated
Synonym: Monohydrated Selenium Dioxide
Synonym: SELENIOUS ACID
Synonym: SELENIUM (AS SELENIOUS ACID)
Synonym: Selenious Acid [Chemical/Ingredient]
Synonym: Selenious acid
Synonym: Selenium Dioxide, Monohydrated
Tree Number: T6.1.46.1
database_cross_reference: DRUGBANK:DB11127
database_cross_reference: MEDCIN:250040
database_cross_reference: MMSL:1562
database_cross_reference: MMSL:5449
database_cross_reference: MSH:D020887
database_cross_reference: MTHSPL:F6A27P4Q4R
database_cross_reference: NCI:C87344
database_cross_reference: NCI_FDA:F6A27P4Q4R
database_cross_reference: NDDF:007254
database_cross_reference: NDDF:011641
database_cross_reference: NDFRT:N0000006282
database_cross_reference: NDFRT:N0000146552
database_cross_reference: NDFRT:N0000146553
database_cross_reference: RXNORM:36344
database_cross_reference: SNOMEDCT_US:712681009
database_cross_reference: VANDF:4018220
database_cross_reference: VANDF:4018221

Selenic Acid
type: Class
subclass of: Selenium Compounds
MCID: MC00037554
PMOID: PMO:00015597
Subclass_of: Selenium Compounds
Synonym: Acid, Selenic
Synonym: Selenic Acid [Chemical/Ingredient]
Synonym: selenic acid
Tree Number: T6.1.46.2
database_cross_reference: MSH:D064586
database_cross_reference: NDDF:011639
database_cross_reference: NDFRT:N0000189404

Selenium Oxides
type: Class
subclass of: Selenium Compounds
MCID: MC00943930
PMOID: PMO:00015598
Subclass_of: Selenium Compounds
Synonym: Oxides, Selenium
Synonym: Selenium Oxides [Chemical/Ingredient]
Tree Number: T6.1.46.3
database_cross_reference: MSH:D064588
database_cross_reference: NDFRT:N0000189488

Cadmium Compounds
type: Class
subclass of: Inorganic Chemicals
MCID: MC00106714
PMOID: PMO:00015599
Subclass_of: Inorganic Chemicals
Synonym: CADMIUM CPDS
Synonym: Cadmium Compound
Synonym: Cadmium Compounds [Chemical/Ingredient]
Synonym: Cadmium Compounds, Inorganic
Synonym: Cadmium compounds
Synonym: Compounds, Cadmium
Tree Number: T6.1.47
database_cross_reference: LCH_NW:sh85018645
database_cross_reference: MSH:D019187
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44349
database_cross_reference: NDFRT:N0000166088

Coordination Complexes
type: Class
subclass of: Inorganic Chemicals
subclass of: Organometallic Compounds
MCID: MC00182822
PMOID: PMO:00015600
Subclass_of: Inorganic Chemicals
Subclass_of: Organometallic Compounds
Synonym: Complexes, Coordination
Synonym: Complexes, Metal
Synonym: Coordination Complexes [Chemical/Ingredient]
Synonym: Metal Complexes
Synonym: Metal complexes
Synonym: metal complex
Tree Number: T6.1.48
Tree Number: T6.2.28.16
database_cross_reference: CSP:1851-2732
database_cross_reference: LCH_NW:sh88005204
database_cross_reference: MSH:D056831
database_cross_reference: NDFRT:N0000180217

Iron Compounds
type: Class
subclass of: Inorganic Chemicals
subclass of: Organometallic Compounds
MCID: MC00224505
PMOID: PMO:00015601
Subclass_of: Inorganic Chemicals
Subclass_of: Organometallic Compounds
Synonym: Compounds, Iron
Synonym: Iron Compounds [Chemical/Ingredient]
Synonym: Iron Compounds, Unspecified
Synonym: Iron compound
Synonym: Iron compound (substance)
Synonym: Iron compound, NOS
Synonym: Iron compounds
Tree Number: T6.1.49
Tree Number: T6.2.28.17
database_cross_reference: LCH_NW:sh85068181
database_cross_reference: MSH:D058085
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008199
database_cross_reference: SNMI:C-13010
database_cross_reference: SNOMEDCT_US:71482002

Ferric Compounds
type: Class
subclass of: Iron Compounds
MCID: MC00005039
PMOID: PMO:00015602
Subclass_of: Iron Compounds
Synonym: Compounds, Ferric
Synonym: FERRIC CPDS
Synonym: Ferric Compounds [Chemical/Ingredient]
Synonym: Ferric iron compound
Synonym: Ferric iron compound (substance)
Synonym: Ferric iron compound, NOS
Tree Number: T6.1.49.1
Tree Number: T6.2.28.17.1
database_cross_reference: MSH:D005290
database_cross_reference: NDFRT:N0000007754
database_cross_reference: SNM:E-5172
database_cross_reference: SNMI:C-13030
database_cross_reference: SNOMEDCT_US:111072007

Ferrous Compounds
type: Class
subclass of: Iron Compounds
MCID: MC00005051
PMOID: PMO:00015603
Subclass_of: Iron Compounds
Synonym: Compounds, Ferrous
Synonym: FERROUS CPDS
Synonym: Ferrous Compounds [Chemical/Ingredient]
Tree Number: T6.1.49.2
Tree Number: T6.2.28.17.2
database_cross_reference: MSH:D005296
database_cross_reference: NDFRT:N0000007760

Iron, Dietary
type: Class
subclass of: Iron Compounds
MCID: MC00133350
PMOID: PMO:00015604
Subclass_of: Iron Compounds
Synonym: Dietary Iron
Synonym: Fe
Synonym: Iron
Synonym: Iron, Dietary [Chemical/Ingredient]
Synonym: dietary iron
Synonym: iron dietary
Tree Number: T6.1.49.4
Tree Number: T6.2.28.17.3
database_cross_reference: CHV:0000031793
database_cross_reference: CSP:2116-5642
database_cross_reference: MSH:D019266
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C68256
database_cross_reference: NCI_CRCH:C68256
database_cross_reference: NDFRT:N0000166154

Iron Carbonyl Compounds
type: Class
subclass of: Iron Compounds
MCID: MC00029453
PMOID: PMO:00015605
Subclass_of: Iron Compounds
Synonym: Carbonyl Compounds, Iron
Synonym: Compounds, Iron Carbonyl
Synonym: Iron Carbonyl Compounds [Chemical/Ingredient]
Synonym: carbonyl iron
Synonym: iron carbonyl
Synonym: iron carbonyl compounds
Tree Number: T6.1.49.5
Tree Number: T6.2.28.17.4
database_cross_reference: CHV:0000014228
database_cross_reference: MSH:D054354
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178593

Organic Chemicals
type: Class
subclass of: Chemical and Drug
MCID: MC00009221
PMOID: PMO:00015606
Subclass_of: Chemical and Drug
Synonym: Chemicals, Organic
Synonym: Organic Chemical
Synonym: Organic Chemicals [Chemical/Ingredient]
Synonym: Organic Compounds
Synonym: Organic chemical
Synonym: Organic chemical, NOS
Synonym: Organic compound
Synonym: Organic compound (substance)
Synonym: Organic compound, NOS
Synonym: Organic compounds
Tree Number: T6.2
database_cross_reference: AOD:0000019649
database_cross_reference: CHV:0000009018
database_cross_reference: CSP:0631-3259
database_cross_reference: LCH:U006539
database_cross_reference: LCH_NW:sh85095499
database_cross_reference: MSH:D009930
database_cross_reference: NCI:C718
database_cross_reference: NDFRT:N0000007676
database_cross_reference: RCD:XM0Eg
database_cross_reference: SNM:E-5400
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:C-10092
database_cross_reference: SNOMEDCT_US:41175001

Dioxins and Dioxin-like Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC01054885
PMOID: PMO:00015607
Subclass_of: Organic Chemicals
Synonym: Dioxins and Dioxin like Compounds
Synonym: Dioxins and Dioxin-like Compounds [Chemical/Ingredient]
Tree Number: T6.2.1
database_cross_reference: MSH:D000072316
database_cross_reference: NDFRT:N0000193171

Dibenzofurans, Polychlorinated
type: Class
subclass of: Dioxins and Dioxin-like Compounds
MCID: MC01054806
PMOID: PMO:00015608
Subclass_of: Dioxins and Dioxin-like Compounds
Synonym: Dibenzofurans, Polychlorinated [Chemical/Ingredient]
Synonym: Polychlorinated Dibenzofurans
Tree Number: T6.2.1.1
database_cross_reference: MSH:D000072338
database_cross_reference: NDFRT:N0000193127

Dioxins
type: Class
subclass of: Dioxins and Dioxin-like Compounds
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00003996
PMOID: PMO:00015609
Subclass_of: Dioxins and Dioxin-like Compounds
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Dioxin
Synonym: Dioxin (category)
Synonym: Dioxin (category) (substance)
Synonym: Dioxin (category, substance) (substance)
Synonym: Dioxin Compound
Synonym: Dioxins [Chemical/Ingredient]
Synonym: dioxin
Synonym: dioxins
Tree Number: T6.2.1.2
Tree Number: T6.3.5.8
database_cross_reference: AOD:0000020729
database_cross_reference: CHV:0000003978
database_cross_reference: LCH:U001405
database_cross_reference: LCH_NW:sh85038140
database_cross_reference: MSH:D004147
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C442
database_cross_reference: NDFRT:N0000167045
database_cross_reference: SNOMEDCT_US:116281006

Polychlorinated Dibenzodioxins
type: Class
subclass of: Dioxins
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC01054808
PMOID: PMO:00015610
Subclass_of: Dioxins
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Chlorinated Dibenzo p dioxins
Synonym: Chlorinated Dibenzo-p-dioxins
Synonym: Dibenzo-p-dioxins, Chlorinated
Synonym: Dibenzo-p-dioxins, Polychlorinated
Synonym: Dibenzodioxin, Polychlorinated
Synonym: Dibenzodioxins, Polychlorinated
Synonym: Polychlorinated Dibenzo p dioxins
Synonym: Polychlorinated Dibenzo-p-dioxins
Synonym: Polychlorinated Dibenzodioxin
Synonym: Polychlorinated Dibenzodioxins [Chemical/Ingredient]
Tree Number: T6.2.1.2.1
Tree Number: T6.3.1.2.2
database_cross_reference: MSH:D000072317
database_cross_reference: NDFRT:N0000193129

Polychlorinated Biphenyls
type: Class
subclass of: Dioxins and Dioxin-like Compounds
MCID: MC00010401
PMOID: PMO:00015612
Subclass_of: Dioxins and Dioxin-like Compounds
Synonym: Biphenyls, Polychlorinated
Synonym: Chlorinated Biphenyls
Synonym: Chlorinated Biphenylsl
Synonym: Chlorobiphenyls
Synonym: Compounds, Polychlorobiphenyl
Synonym: PCB
Synonym: PCBs
Synonym: POLYCHLOROBIPHENYL CPDS
Synonym: Polychlorinated Biphenyl
Synonym: Polychlorinated Biphenyls [Chemical/Ingredient]
Tree Number: T6.2.1.3
database_cross_reference: CHV:0000009905
database_cross_reference: CSP:1372-6747
database_cross_reference: LCH:U006012
database_cross_reference: LCH_NW:sh85104599
database_cross_reference: LNC:LP16832-5
database_cross_reference: LNC:MTHU005566
database_cross_reference: MSH:D011078
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C760
database_cross_reference: NDFRT:N0000166408
database_cross_reference: RCD:X797s
database_cross_reference: SNM:E-6957
database_cross_reference: SNMI:C-29051
database_cross_reference: SNOMEDCT_US:42001007

Aroclors
type: Class
subclass of: Polychlorinated Biphenyls
MCID: MC00001236
PMOID: PMO:00015613
Subclass_of: Polychlorinated Biphenyls
Synonym: Aroclors [Chemical/Ingredient]
Tree Number: T6.2.1.3.1
database_cross_reference: LNC:LP175707-1
database_cross_reference: MSH:D001140
database_cross_reference: NDFRT:N0000166319

Alcohols
type: Class
subclass of: Organic Chemicals
MCID: MC00000522
PMOID: PMO:00015615
Subclass_of: Organic Chemicals
Synonym: 210 ALCOHOLS
Synonym: ALCOHOL
Synonym: ALCOHOLS
Synonym: Alcohol
Synonym: Alcohol (substance)
Synonym: Alcohol [Chemical Class]
Synonym: Alcohol, NOS
Synonym: Alcohols [Chemical/Ingredient]
Synonym: alcohol
Synonym: alcohol in any form
Tree Number: T6.2.2
database_cross_reference: AOD:0000000064
database_cross_reference: AOD:0000000479
database_cross_reference: AOD:0000019695
database_cross_reference: CCPSS:0063702
database_cross_reference: CHV:0000000876
database_cross_reference: CSP:0081-1009
database_cross_reference: DRUGBANK:DB02325
database_cross_reference: LCH:U000130
database_cross_reference: LCH:U000134
database_cross_reference: LCH_NW:sh85003314
database_cross_reference: MSH:D000438
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C218
database_cross_reference: NCI_DTP:NSC0085228
database_cross_reference: NDFRT:N0000007439
database_cross_reference: PSY:01760
database_cross_reference: RCD:X79AZ
database_cross_reference: SNM:E-5510
database_cross_reference: SNM:U000134
database_cross_reference: SNMI:C-21000
database_cross_reference: SNOMEDCT_US:53041004

Ethanol
type: Class
subclass of: Alcohols
MCID: MC00000516
PMOID: PMO:00015616
Subclass_of: Alcohols
Synonym: 1-Hydroxyethane
Synonym: 1.8oz Hand Sanitizer With Clip -assorted
Synonym: 10 Person ANSI
Synonym: 2 Pack Assured Instant Hand Sanitizer with moisturizers (Vitamin E and aloe)
Synonym: 2 Pack Assured Instant Hand Sanitizer with moisturizers (Vitamin E and aloe) lemon scented
Synonym: 2-Pack Hand Sanitizer
Synonym: 25 Person ANSI
Synonym: 2pk 2oz Hand Sanitiizer-aloe Vera
Synonym: 3 Hand Sanitizers
Synonym: 3 Hand Sanitizers Kit
Tree Number: T6.2.2.1
database_cross_reference: AOD:0000000480
database_cross_reference: AOD:0000000576
database_cross_reference: AOD:0000021272
database_cross_reference: AOD:0000021273
database_cross_reference: ATC:D08AX08
database_cross_reference: ATC:V03AB16
database_cross_reference: ATC:V03AZ01
database_cross_reference: CHV:0000000869
database_cross_reference: CSP:0081-2416
database_cross_reference: DRUGBANK:DB00898
database_cross_reference: DRUGBANK:DB02325
database_cross_reference: LCH_NW:sh2009007801
database_cross_reference: LNC:LP14348-4
database_cross_reference: LNC:LP20735-4
database_cross_reference: LNC:MTHU001345
database_cross_reference: MEDLINEPLUS:1558
database_cross_reference: MMSL:10010
database_cross_reference: MMSL:4693
database_cross_reference: MMSL:9888
database_cross_reference: MMSL:d03162
database_cross_reference: MSH:D000431
database_cross_reference: MTH:U001669
database_cross_reference: MTHSPL:3K9958V90M
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C2190
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_DCP:00164
database_cross_reference: NCI_DTP:NSC0085228
database_cross_reference: NCI_FDA:3K9958V90M
database_cross_reference: NCI_NCI-GLOSS:CDR0000463134
database_cross_reference: NDDF:001539
database_cross_reference: NDDF:002464
database_cross_reference: NDFRT:N0000007432
database_cross_reference: NDFRT:N0000145812
database_cross_reference: NDFRT:N0000146104
database_cross_reference: PDQ:CDR0000446576
database_cross_reference: PSY:01653
database_cross_reference: PSY:18040
database_cross_reference: PSY:18170
database_cross_reference: RCD:X80AK
database_cross_reference: RXNORM:448
database_cross_reference: SNM:E-5512
database_cross_reference: SNMI:C-21005
database_cross_reference: SNOMEDCT_US:32055008
database_cross_reference: SNOMEDCT_US:398624005
database_cross_reference: SNOMEDCT_US:419442005
database_cross_reference: VANDF:4017424
database_cross_reference: VANDF:4017736

Blood Alcohol Content
type: Class
subclass of: Ethanol
PMOID: PMO:00015617
Subclass_of: Ethanol
Tree Number: T6.2.2.1.1

Ethamoxytriphetol
type: Class
subclass of: Ethanol
MCID: MC00004759
PMOID: PMO:00015618
Subclass_of: Ethanol
Synonym: Benzeneethanol, alpha-(4-(2-(diethylamino)ethoxy)phenyl)-4-methoxy-alpha-phenyl-
Synonym: Ethamoxytriphetol (substance)
Synonym: Ethamoxytriphetol [Chemical/Ingredient]
Synonym: ethamoxytriphetol
Tree Number: T6.2.2.1.2
database_cross_reference: AOD:0000000481
database_cross_reference: MSH:D004978
database_cross_reference: NDFRT:N0000166824
database_cross_reference: SNMI:C-A3210
database_cross_reference: SNOMEDCT_US:96377004

Ethanolamines
type: Class
subclass of: Ethanol
subclass of: Amino Alcohols
MCID: MC00004764
PMOID: PMO:00015619
Subclass_of: Amino Alcohols
Subclass_of: Ethanol
Synonym: Aminoethanols
Synonym: Ethanolamine
Synonym: Ethanolamines [Chemical/Ingredient]
Synonym: aminoethanol
Synonym: ethanolamine
Synonym: ethanolamines
Tree Number: T6.2.2.1.3
Tree Number: T6.2.2.3.1
Tree Number: T6.2.6.2.1
database_cross_reference: AOD:0000020135
database_cross_reference: CHV:0000004687
database_cross_reference: DRUGBANK:DB03994
database_cross_reference: LCH:U001671
database_cross_reference: LCH_NW:sh85045075
database_cross_reference: MSH:D004983
database_cross_reference: MTH:U001906
database_cross_reference: NDFRT:N0000007805

Ethylene Chlorohydrin
type: Class
subclass of: Ethanol
subclass of: Chlorohydrins
MCID: MC00004798
PMOID: PMO:00015621
Subclass_of: Chlorohydrins
Subclass_of: Ethanol
Synonym: 2 Chlorethanol
Synonym: 2 Chloroethyl Alcohol
Synonym: 2-Chlorethanol
Synonym: 2-Chloroethanol
Synonym: 2-Chloroethyl Alcohol
Synonym: 2-Hydroxyethyl Chloride
Synonym: 2-Monochloroethanol
Synonym: Alcohol, 2-Chloroethyl
Synonym: CHLORETHANOL 02
Synonym: CHLOROETHYL ALCOHOL 02
Tree Number: T6.2.2.1.4
Tree Number: T6.2.2.5.4
database_cross_reference: AOD:0000000484
database_cross_reference: MSH:D005023
database_cross_reference: NCI:C122479
database_cross_reference: NCI:iCaRe2
database_cross_reference: NCI_FDA:753N66IHAN
database_cross_reference: NDFRT:N0000166820
database_cross_reference: RCD:X809Y
database_cross_reference: SNM:E-5531
database_cross_reference: SNMI:C-21022
database_cross_reference: SNOMEDCT_US:37318009

Mercaptoethanol
type: Class
subclass of: Ethanol
subclass of: Sulfhydryl Compounds
MCID: MC00008085
PMOID: PMO:00015622
Subclass_of: Ethanol
Subclass_of: Sulfhydryl Compounds
Synonym: 2 Mercaptoethanol
Synonym: 2-ME
Synonym: 2-Mercaptoethanol
Synonym: 2-Mercaptoethanol (substance)
Synonym: Ethanol, 2-mercapto-
Synonym: Mercaptoethanol [Chemical/Ingredient]
Synonym: mercaptoethanol
Tree Number: T6.2.2.1.5
Tree Number: T6.2.32.6.5
database_cross_reference: AOD:0000000485
database_cross_reference: MSH:D008623
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166823
database_cross_reference: RCD:X80BD
database_cross_reference: SNOMEDCT_US:259220007

Phenylethyl Alcohol
type: Class
subclass of: Ethanol
MCID: MC01073544
PMOID: PMO:00015623
Subclass_of: Ethanol
Synonym: 2-phenylethanol
Synonym: Benzeneethanol
Synonym: Phenethyl alcohol
Synonym: Phenylethanol
Synonym: Phenylethyl alcohol
Tree Number: T6.2.2.1.6
database_cross_reference: DRUGBANK:DB02192

Trifluoroethanol
type: Class
subclass of: Ethanol
MCID: MC00013081
PMOID: PMO:00015624
Subclass_of: Ethanol
Synonym: 2,2,2-Trifluoroethanol
Synonym: 2,2,2-Trifluoroethanol (substance)
Synonym: Alcohol, Trifluoroethyl
Synonym: Ethanol, 2,2,2-trifluoro-
Synonym: Trifluoroethanol [Chemical/Ingredient]
Synonym: Trifluoroethyl Alcohol
Synonym: trifluoroethanol
Tree Number: T6.2.2.1.7
database_cross_reference: AOD:0000000489
database_cross_reference: DRUGBANK:DB03226
database_cross_reference: MSH:D014270
database_cross_reference: NDFRT:N0000166819
database_cross_reference: RCD:X80Cm
database_cross_reference: SNOMEDCT_US:259287007

Methanol
type: Class
subclass of: Alcohols
MCID: MC00000517
PMOID: PMO:00015625
Subclass_of: Alcohols
Synonym: ALCOHOL,METHYL
Synonym: Alcohol Methyl
Synonym: Alcohol, Methyl
Synonym: Alcohol, Wood
Synonym: Carbinol
Synonym: METHANOL
Synonym: METHYL ALCOHOL
Synonym: Methanol (substance)
Synonym: Methanol [Chemical/Ingredient]
Synonym: Methyl Alcohol
Tree Number: T6.2.2.2
database_cross_reference: AOD:0000019697
database_cross_reference: AOD:0000028736
database_cross_reference: AOD:0000028737
database_cross_reference: CHV:0000000870
database_cross_reference: CSP:0081-2617
database_cross_reference: LCH_NW:sh85084383
database_cross_reference: LNC:LP14349-2
database_cross_reference: LNC:MTHU005019
database_cross_reference: MDDB:06208
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000432
database_cross_reference: MTH:U001670
database_cross_reference: MTHSPL:Y4S76JWI15
database_cross_reference: NCI:C217
database_cross_reference: NCI_DCP:03096
database_cross_reference: NCI_DTP:NSC0085232
database_cross_reference: NCI_FDA:Y4S76JWI15
database_cross_reference: NDDF:002467
database_cross_reference: NDFRT:N0000007433
database_cross_reference: NDFRT:N0000022622
database_cross_reference: PSY:31100
database_cross_reference: PSY:31170
database_cross_reference: RCD:X80BF
database_cross_reference: RCD:XaD1M
database_cross_reference: RXNORM:1310568
database_cross_reference: SNM:E-5511
database_cross_reference: SNMI:C-21002
database_cross_reference: SNOMEDCT_US:259221006
database_cross_reference: SNOMEDCT_US:29846004
database_cross_reference: SNOMEDCT_US:311730004
database_cross_reference: VANDF:4019992

Amino Alcohols
type: Class
subclass of: Alcohols
subclass of: Amines
MCID: MC00000747
PMOID: PMO:00015626
Subclass_of: Alcohols
Subclass_of: Amines
Synonym: Alcohols, Amino
Synonym: Amino Alcohols [Chemical/Ingredient]
Synonym: Amino alcohol
Synonym: Amino alcohol (substance)
Synonym: Amino alcohols
Synonym: Aminoalcohol, NOS
Synonym: amino alcohols
Synonym: aminoalcohol
Tree Number: T6.2.2.3
Tree Number: T6.2.6.2
database_cross_reference: AOD:0000020134
database_cross_reference: CSP:0125-4910
database_cross_reference: LCH:U000195
database_cross_reference: LCH_NW:sh85004493
database_cross_reference: MSH:D000605
database_cross_reference: NDFRT:N0000007838
database_cross_reference: SNMI:C-67710
database_cross_reference: SNOMEDCT_US:55816008

Mometasone Furoate, Formoterol Fumarate Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC01007816
PMOID: PMO:00015629
Subclass_of: Drug Combinations
Synonym: Mometasone Furoate Formoterol Fumarate Drug Combination
Synonym: Mometasone Furoate, Formoterol Fumarate Drug Combination [Chemical/Ingredient]
Synonym: Mometasone Furoate-Formoterol Fumarate Drug Combination
Tree Number: T6.15.3.8
database_cross_reference: MSH:D000068758
database_cross_reference: NDFRT:N0000192006

Budesonide, Formoterol Fumarate Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC01007800
PMOID: PMO:00015630
Subclass_of: Drug Combinations
Synonym: Budesonide Formoterol Drug Combination
Synonym: Budesonide Formoterol Fumarate Drug Combination
Synonym: Budesonide, Formoterol Fumarate Drug Combination [Chemical/Ingredient]
Synonym: Budesonide-Formoterol Drug Combination
Synonym: Budesonide-Formoterol Fumarate Drug Combination
Synonym: Combination, Budesonide-Formoterol Drug
Synonym: Drug Combination, Budesonide-Formoterol
Tree Number: T6.15.3.15
database_cross_reference: MSH:D000069502
database_cross_reference: NDFRT:N0000191996

Fluticasone-Salmeterol Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00335720
PMOID: PMO:00015633
Subclass_of: Drug Combinations
Synonym: Combination, Fluticasone-Salmeterol
Synonym: Combination, Fluticasone-Salmeterol Drug
Synonym: Drug Combination, Fluticasone-Salmeterol
Synonym: FLUTICASONE/SALMETEROL
Synonym: Fluticasone + Salmeterol
Synonym: Fluticasone + salmeterol
Synonym: Fluticasone + salmeterol (product)
Synonym: Fluticasone - Salmeterol
Synonym: Fluticasone Salmeterol
Synonym: Fluticasone Salmeterol Combination
Tree Number: T6.15.3.2
database_cross_reference: ATC:R03AK06
database_cross_reference: CHV:0000052902
database_cross_reference: GS:43215
database_cross_reference: GS:43216
database_cross_reference: GS:43269
database_cross_reference: GS:44237
database_cross_reference: GS:44238
database_cross_reference: GS:44239
database_cross_reference: GS:78968
database_cross_reference: GS:78969
database_cross_reference: GS:78970
database_cross_reference: MMSL:d04611
database_cross_reference: MSH:D000068297
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000022222
database_cross_reference: NDFRT:N0000191957
database_cross_reference: RXNORM:284635
database_cross_reference: SNOMEDCT_US:411106009
database_cross_reference: VANDF:4024217

Albuterol, Ipratropium Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00240339
PMOID: PMO:00015634
Subclass_of: Drug Combinations
Synonym: ALBUTEROL/IPRATROPIUM
Synonym: Albuterol + ipratropium
Synonym: Albuterol + ipratropium (product)
Synonym: Albuterol / Ipratropium
Synonym: Albuterol Ipratropium
Synonym: Albuterol Ipratropium Drug Combination
Synonym: Albuterol+ipratropium
Synonym: Albuterol+ipratropium (product)
Synonym: Albuterol, Ipratropium Drug Combination [Chemical/Ingredient]
Synonym: Albuterol-Ipratropium
Tree Number: T6.15.3.6
database_cross_reference: CHV:0000045133
database_cross_reference: GS:82201
database_cross_reference: GS:82203
database_cross_reference: MMSL:d04066
database_cross_reference: MSH:D000068600
database_cross_reference: NCI:C29129
database_cross_reference: NDFRT:N0000022065
database_cross_reference: NDFRT:N0000191928
database_cross_reference: RXNORM:214199
database_cross_reference: SNOMEDCT_US:421685007
database_cross_reference: VANDF:4024060

Choline
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00002742
PMOID: PMO:00015636
Subclass_of: Quaternary Ammonium Compounds
Synonym: (2-Hydroxyethyl)trimethylammonium
Synonym: 2-Hydroxy-N,N,N-trimethylethanaminium
Synonym: 2-hydroxyethyl-trimethyl-ammonium
Synonym: Advanced 2000 Capsules
Synonym: Alertonic
Synonym: American Eagle Energizer Plus Vitamin Supplement Drink
Synonym: American Plus Energy & Vitamin Drink
Synonym: B 50 Capsules
Synonym: B Complex 25mg Vitamin Supplement
Synonym: B Complex 50 Vitamin Cap
Tree Number: T6.2.27.1.10
database_cross_reference: AOD:0000018517
database_cross_reference: CHV:0000002888
database_cross_reference: CSP:0663-0420
database_cross_reference: DRUGBANK:DB00122
database_cross_reference: LCH:U000991
database_cross_reference: LCH_NW:sh85024656
database_cross_reference: MMSL:4436
database_cross_reference: MMSL:4875
database_cross_reference: MMSL:d03159
database_cross_reference: MSH:D002794
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:N91BDP6H0X
database_cross_reference: NCI:C61674
database_cross_reference: NCI_CRCH:C61674
database_cross_reference: NCI_DCP:00994
database_cross_reference: NCI_FDA:N91BDP6H0X
database_cross_reference: NCI_NCI-GLOSS:CDR0000556410
database_cross_reference: NDDF:002058
database_cross_reference: NDFRT:N0000007087
database_cross_reference: NDFRT:N0000146071
database_cross_reference: PSY:09030
database_cross_reference: RCD:Ub08Y
database_cross_reference: RXNORM:2449
database_cross_reference: SNM:E-8768
database_cross_reference: SNM:F-11620
database_cross_reference: SNMI:C-A4030
database_cross_reference: SNMI:F-61620
database_cross_reference: SNOMEDCT_US:111156002
database_cross_reference: SNOMEDCT_US:386992005
database_cross_reference: SNOMEDCT_US:65123005
database_cross_reference: VANDF:4017699

Platelet Activating Factor
type: Class
subclass of: PMO:00021947
subclass of: PMO:00024397
MCID: MC00010308
PMOID: PMO:00015637
Subclass_of: Autacoids
Subclass_of: Blood Coagulation Factors
Synonym: 1 Alkyl 2 acetyl sn glycerophosphocholine
Synonym: 1-Alkyl-2-acetyl-sn-glycerophosphocholine
Synonym: 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
Synonym: AGEPC
Synonym: Acetyl Glyceryl Ether Phosphorylcholine
Synonym: Aggregating Factor, Platelet
Synonym: Factor, Platelet Activating
Synonym: PAF
Synonym: PAF Acether
Synonym: PAF-Acether
Tree Number: T6.13.10.2.4
Tree Number: T6.13.4.17
database_cross_reference: AOD:0000020031
database_cross_reference: CHV:0000009828
database_cross_reference: CSP:0445-3954
database_cross_reference: DRUGBANK:DB02261
database_cross_reference: LCH:U003716
database_cross_reference: LCH_NW:sh85103285
database_cross_reference: MSH:D010972
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16998
database_cross_reference: NDFRT:N0000171496
database_cross_reference: SNM:F-47040
database_cross_reference: SNMI:F-CB440
database_cross_reference: SNOMEDCT_US:43278003

Epinephrine
type: Class
subclass of: Catecholamines
MCID: MC00004610
PMOID: PMO:00015640
Subclass_of: Catecholamines
Synonym: (-)-(R)-Epinephrine
Synonym: (R)-(-)-Adnephrine
Synonym: (R)-(-)-Adrenaline
Synonym: (R)-(-)-Epinephrine
Synonym: (R)-(-)-Epirenamine
Synonym: (R)-(-)-adrenaline
Synonym: (R)-(−)-adrenaline
Synonym: (−)-adrenaline
Synonym: 1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-
Synonym: 2% Lidocaine and Epinephrine 1:100,000 Injection USP
Tree Number: T6.2.6.9.4
database_cross_reference: AOD:0000018735
database_cross_reference: AOD:0000028375
database_cross_reference: ATC:A01AD01
database_cross_reference: ATC:B02BC09
database_cross_reference: ATC:C01CA24
database_cross_reference: ATC:R01AA14
database_cross_reference: ATC:R03AA01
database_cross_reference: ATC:S01EA01
database_cross_reference: CHV:0000004565
database_cross_reference: CSP:2268-5502
database_cross_reference: DRUGBANK:DB00668
database_cross_reference: FMA:67243
database_cross_reference: LCH:U005523
database_cross_reference: LCH_NW:sh85001007
database_cross_reference: LNC:LP15027-3
database_cross_reference: LNC:MTHU002341
database_cross_reference: MEDCIN:198367
database_cross_reference: MEDCIN:41185
database_cross_reference: MMSL:3451
database_cross_reference: MMSL:4663
database_cross_reference: MMSL:d00699
database_cross_reference: MSH:D004837
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:YKH834O4BH
database_cross_reference: NCI:C2292
database_cross_reference: NCI:C473
database_cross_reference: NCI_DTP:NSC0062786
database_cross_reference: NCI_FDA:YKH834O4BH
database_cross_reference: NCI_NCI-GLOSS:CDR0000045404
database_cross_reference: NCI_NCI-GLOSS:CDR0000046758
database_cross_reference: NDDF:001774
database_cross_reference: NDFRT:N0000006261
database_cross_reference: NDFRT:N0000146377
database_cross_reference: PDQ:CDR0000041857
database_cross_reference: PSY:01060
database_cross_reference: PSY:17700
database_cross_reference: RCD:X80FK
database_cross_reference: RCD:bp1..
database_cross_reference: RCD:c21..
database_cross_reference: RCD:x02LH
database_cross_reference: RXNORM:3992
database_cross_reference: SNM:F-25910
database_cross_reference: SNMI:C-68060
database_cross_reference: SNMI:F-B2110
database_cross_reference: SNOMEDCT_US:259342005
database_cross_reference: SNOMEDCT_US:319480007
database_cross_reference: SNOMEDCT_US:320288006
database_cross_reference: SNOMEDCT_US:354037007
database_cross_reference: SNOMEDCT_US:372575003
database_cross_reference: SNOMEDCT_US:387362001
database_cross_reference: SNOMEDCT_US:391721000
database_cross_reference: SNOMEDCT_US:65502005
database_cross_reference: SNOMEDCT_US:78890004
database_cross_reference: USPMG:MTHU000797
database_cross_reference: UWDA:67243
database_cross_reference: VANDF:4018034

Isoproterenol
type: Class
subclass of: Catecholamines
MCID: MC00007111
PMOID: PMO:00015642
Subclass_of: Catecholamines
Synonym: (+-)-Isoprenaline
Synonym: (+-)-Isoproterenol
Synonym: (Â±)-isoprenaline
Synonym: (Â±)-isoproterenol
Synonym: 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-
Synonym: 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol
Synonym: 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol
Synonym: 3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol
Synonym: 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol
Synonym: ISOPROTERENOL
Tree Number: T6.2.6.9.5
database_cross_reference: AOD:0000020142
database_cross_reference: ATC:C01CA02
database_cross_reference: ATC:R03AB02
database_cross_reference: ATC:R03CB01
database_cross_reference: CHV:0000006964
database_cross_reference: CSP:2268-5748
database_cross_reference: DRUGBANK:DB01064
database_cross_reference: LCH:U002525
database_cross_reference: LCH_NW:sh85068667
database_cross_reference: MEDCIN:41474
database_cross_reference: MMSL:d00697
database_cross_reference: MSH:D007545
database_cross_reference: MTHSPL:L628TT009W
database_cross_reference: NCI:C62041
database_cross_reference: NCI_DCP:01867
database_cross_reference: NCI_FDA:L628TT009W
database_cross_reference: NDDF:001778
database_cross_reference: NDFRT:N0000006336
database_cross_reference: NDFRT:N0000147882
database_cross_reference: PSY:26740
database_cross_reference: RCD:x01Cu
database_cross_reference: RXNORM:6054
database_cross_reference: SNM:E-7478
database_cross_reference: SNMI:C-68080
database_cross_reference: SNOMEDCT_US:372781009
database_cross_reference: SNOMEDCT_US:57845006
database_cross_reference: VANDF:4019793

Labetalol
type: Class
subclass of: Salicylamides
MCID: MC00007305
PMOID: PMO:00015643
Subclass_of: Salicylamides
Synonym: 3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol
Synonym: 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide
Synonym: Apo-labetalol Tablets
Synonym: Benzamide, 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-
Synonym: LABETALOL
Synonym: Labetalol (product)
Synonym: Labetalol (substance)
Synonym: Labetalol Hydrochloride Injection
Synonym: Labetalol Hydrochloride Injection USP
Synonym: Labetalol Hydrochloride Injection, USP
Tree Number: T6.2.4.12.1
database_cross_reference: ATC:C07AG01
database_cross_reference: CHV:0000007150
database_cross_reference: DRUGBANK:DB00598
database_cross_reference: LCH:U002598
database_cross_reference: LCH_NW:sh85073626
database_cross_reference: LNC:LP16170-0
database_cross_reference: LNC:MTHU007202
database_cross_reference: MEDCIN:340428
database_cross_reference: MMSL:d00016
database_cross_reference: MSH:D007741
database_cross_reference: MTHSPL:R5H8897N95
database_cross_reference: NCI:C29146
database_cross_reference: NCI_DCP:30283
database_cross_reference: NCI_FDA:R5H8897N95
database_cross_reference: NDDF:001839
database_cross_reference: NDFRT:N0000006446
database_cross_reference: NDFRT:N0000147886
database_cross_reference: RCD:x01C7
database_cross_reference: RXNORM:6185
database_cross_reference: SNMI:C-81190
database_cross_reference: SNOMEDCT_US:372750000
database_cross_reference: SNOMEDCT_US:46547007
database_cross_reference: USPMG:MTHU000762
database_cross_reference: VANDF:4019797

Norepinephrine
type: Class
subclass of: Amino Alcohols
subclass of: Catecholamines
MCID: MC00008996
PMOID: PMO:00015645
Subclass_of: Amino Alcohols
Subclass_of: Catecholamines
Synonym: (-)-Arterenol
Synonym: (-)-Noradrenaline
Synonym: (-)-Norepinephrine
Synonym: (-)-alpha-(aminomethyl)-3,4-dihydroxybenzyl Alcohol
Synonym: (R)-(-)-Norepinephrine
Synonym: (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol
Synonym: (R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol
Synonym: (R)-Norepinephrine
Synonym: 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-
Synonym: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
Tree Number: T6.2.6.2.4
Tree Number: T6.2.6.9.6
database_cross_reference: AOD:0000018738
database_cross_reference: AOD:0000028377
database_cross_reference: AOD:0000028378
database_cross_reference: ATC:C01CA03
database_cross_reference: CHV:0000008769
database_cross_reference: CSP:2268-5994
database_cross_reference: DRUGBANK:DB00368
database_cross_reference: FMA:61799
database_cross_reference: LCH:U005856
database_cross_reference: LCH_NW:sh85092392
database_cross_reference: LNC:LP15271-7
database_cross_reference: LNC:MTHU003447
database_cross_reference: MEDCIN:40647
database_cross_reference: MMSL:2706
database_cross_reference: MMSL:d00323
database_cross_reference: MSH:D009638
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:X4W3ENH1CV
database_cross_reference: NCI:C2321
database_cross_reference: NCI_DCP:06013
database_cross_reference: NCI_FDA:X4W3ENH1CV
database_cross_reference: NDDF:004718
database_cross_reference: NDFRT:N0000007426
database_cross_reference: NDFRT:N0000147945
database_cross_reference: PSY:34400
database_cross_reference: PSY:34410
database_cross_reference: RCD:X80FL
database_cross_reference: RCD:x01Cc
database_cross_reference: RXNORM:7512
database_cross_reference: SNM:E-7473
database_cross_reference: SNM:F-25920
database_cross_reference: SNMI:C-680D0
database_cross_reference: SNMI:F-B2120
database_cross_reference: SNOMEDCT_US:111130009
database_cross_reference: SNOMEDCT_US:349918005
database_cross_reference: SNOMEDCT_US:386986004
database_cross_reference: SNOMEDCT_US:45555007
database_cross_reference: UWDA:61799
database_cross_reference: VANDF:4019859

Normetanephrine
type: Class
subclass of: PMO:00024394
MCID: MC00009006
PMOID: PMO:00015646
Subclass_of: Biomarkers, Tumor
Synonym: 3 Methoxynoradrenaline
Synonym: 3-Methoxynoradrenaline
Synonym: Benzenemethanol, alpha-(aminomethyl)-4-hydroxy-3-methoxy-
Synonym: Normetadrenaline
Synonym: Normetanephrine (substance)
Synonym: Normetanephrine [Chemical/Ingredient]
Synonym: normetanephrine
Synonym: normetanephrines
Tree Number: T6.13.9.5.5
database_cross_reference: AOD:0000018740
database_cross_reference: CHV:0000008775
database_cross_reference: CSP:2268-6240
database_cross_reference: LNC:LP15749-2
database_cross_reference: LNC:MTHU004756
database_cross_reference: MSH:D009647
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171373
database_cross_reference: RCD:X80FO
database_cross_reference: SNM:F-25970
database_cross_reference: SNMI:F-B2170
database_cross_reference: SNOMEDCT_US:24939007

Metaproterenol
type: Class
subclass of: Catecholamines
MCID: MC00009215
PMOID: PMO:00015648
Subclass_of: Catecholamines
Synonym: 1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-
Synonym: Alupent Aer
Synonym: Alupent Liq 50mg/ml
Synonym: Alupent Syr 10mg/5.0ml
Synonym: Alupent Tab 20mg
Synonym: METAPROTERENOL
Synonym: Metaproterenol (product)
Synonym: Metaproterenol (substance)
Synonym: Metaproterenol [Chemical/Ingredient]
Synonym: Nu-orciprenaline
Tree Number: T6.2.6.9.7
database_cross_reference: ATC:R03AB03
database_cross_reference: ATC:R03CB03
database_cross_reference: CHV:0000009006
database_cross_reference: DRUGBANK:DB00816
database_cross_reference: LNC:LP17252-5
database_cross_reference: LNC:MTHU023119
database_cross_reference: MMSL:d00750
database_cross_reference: MSH:D009921
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:53QOG569E0
database_cross_reference: NCI:C61834
database_cross_reference: NCI_FDA:53QOG569E0
database_cross_reference: NDDF:004408
database_cross_reference: NDFRT:N0000006698
database_cross_reference: NDFRT:N0000147906
database_cross_reference: RCD:x01Cm
database_cross_reference: RXNORM:7688
database_cross_reference: SNM:E-747X
database_cross_reference: SNMI:C-680A0
database_cross_reference: SNOMEDCT_US:372797004
database_cross_reference: SNOMEDCT_US:6067003
database_cross_reference: USPMG:MTHU001666
database_cross_reference: VANDF:4019817

Heptaminol
type: Class
subclass of: Amino Alcohols
MCID: MC00006152
PMOID: PMO:00015657
Subclass_of: Amino Alcohols
Synonym: 2-Heptanol, 6-amino-2-methyl-
Synonym: Heptaminol (substance)
Synonym: Heptaminol [Chemical/Ingredient]
Synonym: heptaminol
Tree Number: T6.2.2.3.2
Tree Number: T6.2.6.2.2
database_cross_reference: AOD:0000020143
database_cross_reference: ATC:C01DX08
database_cross_reference: CHV:0000006067
database_cross_reference: LNC:LP16159-3
database_cross_reference: LNC:MTHU016803
database_cross_reference: MSH:D006535
database_cross_reference: NDDF:005587
database_cross_reference: NDDF:006399
database_cross_reference: NDFRT:N0000166812
database_cross_reference: RXNORM:5254
database_cross_reference: SNMI:C-68140
database_cross_reference: SNOMEDCT_US:96259006

Isoetharine
type: Class
subclass of: Amino Alcohols
MCID: MC00007080
PMOID: PMO:00015658
Subclass_of: Amino Alcohols
Synonym: 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)butyl)-
Synonym: Etyprenalinum
Synonym: ISOETHARINE
Synonym: Isoetarin
Synonym: Isoetarina
Synonym: Isoetarine
Synonym: Isoetarinum
Synonym: Isoetharine (product)
Synonym: Isoetharine (substance)
Synonym: Isoetharine [Chemical/Ingredient]
Tree Number: T6.2.2.3.3
Tree Number: T6.2.6.2.3
database_cross_reference: ATC:R03AC07
database_cross_reference: ATC:R03CC06
database_cross_reference: CHV:0000006948
database_cross_reference: DRUGBANK:DB00221
database_cross_reference: MEDCIN:41473
database_cross_reference: MMSL:7493
database_cross_reference: MMSL:d00751
database_cross_reference: MSH:D007528
database_cross_reference: NCI:C65974
database_cross_reference: NCI_FDA:YV0SN3276Q
database_cross_reference: NDDF:001783
database_cross_reference: NDFRT:N0000006297
database_cross_reference: NDFRT:N0000147881
database_cross_reference: RXNORM:6023
database_cross_reference: SNM:E-7466
database_cross_reference: SNMI:C-68070
database_cross_reference: SNOMEDCT_US:386181008
database_cross_reference: SNOMEDCT_US:66004009
database_cross_reference: VANDF:4019792

Propanolamines
type: Class
subclass of: Amino Alcohols
subclass of: Propanols
MCID: MC00010706
PMOID: PMO:00015659
Subclass_of: Amino Alcohols
Subclass_of: Propanols
Synonym: Aminopropanols
Synonym: Propanolamine
Synonym: Propanolamine (substance)
Synonym: Propanolamines [Chemical/Ingredient]
Synonym: propanolamine
Tree Number: T6.2.2.10.2
Tree Number: T6.2.2.3.4
Tree Number: T6.2.6.2.5
database_cross_reference: AOD:0000020144
database_cross_reference: LCH_NW:sh94005221
database_cross_reference: MSH:D011412
database_cross_reference: NDFRT:N0000007669
database_cross_reference: SNOMEDCT_US:441338003

Oxyfedrine
type: Class
subclass of: Propiophenones
MCID: MC00009580
PMOID: PMO:00015665
Subclass_of: Propiophenones
Synonym: 1-Propanone, 3-((2-hydroxy-1-methyl-2-phenylethyl)amino)-1-(3-methoxyphenyl)-, (R-(R*,S*))-
Synonym: OXYFEDRINE
Synonym: Oxifedrine
Synonym: Oxiphedrin
Synonym: Oxyfedrine [Chemical/Ingredient]
Synonym: Oxyphedrin
Synonym: oxyfedrine
Tree Number: T6.2.20.14.3
database_cross_reference: ATC:C01DX03
database_cross_reference: CHV:0000009152
database_cross_reference: MSH:D010099
database_cross_reference: NCI:C74199
database_cross_reference: NCI_FDA:DWL616XF1K
database_cross_reference: NDDF:006755
database_cross_reference: NDFRT:N0000166832
database_cross_reference: RXNORM:7805

Brimonidine Tartrate, Timolol Maleate Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC01007818
PMOID: PMO:00015673
Subclass_of: Drug Combinations
Synonym: Brimonidine Tartrate Timolol Maleate
Synonym: Brimonidine Tartrate Timolol Maleate Drug Combination
Synonym: Brimonidine Tartrate, Timolol Maleate Drug Combination [Chemical/Ingredient]
Synonym: Brimonidine Tartrate-Timolol Maleate
Synonym: Brimonidine Tartrate-Timolol Maleate Drug Combination
Synonym: Maleate, Brimonidine Tartrate-Timolol
Synonym: Tartrate-Timolol Maleate, Brimonidine
Tree Number: T6.15.3.5
database_cross_reference: MSH:D000068599
database_cross_reference: NDFRT:N0000192008

Propranolol
type: Class
subclass of: Naphthalenes
MCID: MC00010727
PMOID: PMO:00015689
Subclass_of: Naphthalenes
Synonym: 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
Synonym: 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
Synonym: 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol
Synonym: 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-
Synonym: Apo Propranolol Tab 10mg
Synonym: Apo Propranolol Tab 120mg
Synonym: Apo Propranolol Tab 40mg
Synonym: Apo Propranolol Tab 80mg
Synonym: Apo-propranolol Tab 20mg
Synonym: Ciplar
Tree Number: T6.4.3.7.12
database_cross_reference: AOD:0000020145
database_cross_reference: ATC:C07AA05
database_cross_reference: CHV:0000010206
database_cross_reference: CSP:1993-7252
database_cross_reference: DRUGBANK:DB00571
database_cross_reference: LNC:LP16266-6
database_cross_reference: LNC:MTHU005037
database_cross_reference: MEDCIN:340472
database_cross_reference: MMSL:d00032
database_cross_reference: MSH:D011433
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9Y8NXQ24VQ
database_cross_reference: NCI:C62073
database_cross_reference: NCI_DCP:01564
database_cross_reference: NCI_FDA:9Y8NXQ24VQ
database_cross_reference: NDDF:004740
database_cross_reference: NDFRT:N0000006760
database_cross_reference: NDFRT:N0000148001
database_cross_reference: PSY:41100
database_cross_reference: RCD:x01CD
database_cross_reference: RXNORM:8787
database_cross_reference: SNM:E-7674
database_cross_reference: SNMI:C-80450
database_cross_reference: SNOMEDCT_US:372772003
database_cross_reference: SNOMEDCT_US:55745002
database_cross_reference: USPMG:MTHU000438
database_cross_reference: VANDF:4019916

Celiprolol
type: Class
subclass of: Phenylurea Compounds
MCID: MC00022571
PMOID: PMO:00015692
Subclass_of: Phenylurea Compounds
Synonym: CELIPROLOL
Synonym: Cardem
Synonym: Celipres
Synonym: Celipro
Synonym: Celiprolol (product)
Synonym: Celiprolol (substance)
Synonym: Celiprolol [Chemical/Ingredient]
Synonym: Celol
Synonym: Cordiax
Synonym: Dilanorm
Tree Number: T6.2.34.8.5
database_cross_reference: ATC:C07AB08
database_cross_reference: CHV:0000013704
database_cross_reference: DRUGBANK:DB04846
database_cross_reference: MSH:D017272
database_cross_reference: NCI:C79558
database_cross_reference: NCI_FDA:DRB57K47QC
database_cross_reference: NDDF:003948
database_cross_reference: NDFRT:N0000166834
database_cross_reference: NDFRT:N0000171770
database_cross_reference: RCD:x01C2
database_cross_reference: RXNORM:20498
database_cross_reference: SNOMEDCT_US:349901006
database_cross_reference: SNOMEDCT_US:395960002
database_cross_reference: VANDF:4025238

Sphingosine
type: Class
subclass of: Amino Alcohols
subclass of: Glycols
MCID: MC00012121
PMOID: PMO:00015698
Subclass_of: Amino Alcohols
Subclass_of: Glycols
Synonym: 4 Sphingenine
Synonym: 4-Octadecene-1,3-diol, 2-amino-, (R-(R*,S*-(E)))-
Synonym: 4-Sphingenine
Synonym: Sphingosine (substance)
Synonym: Sphingosine [Chemical/Ingredient]
Synonym: sphingosine
Tree Number: T6.2.2.3.5
Tree Number: T6.2.2.7.4
Tree Number: T6.2.6.2.6
database_cross_reference: CHV:0000011604
database_cross_reference: CSP:2757-0560
database_cross_reference: DRUGBANK:DB03203
database_cross_reference: LCH:U004426
database_cross_reference: LCH_NW:sh85126607
database_cross_reference: MSH:D013110
database_cross_reference: NDFRT:N0000166817
database_cross_reference: RCD:X80OE
database_cross_reference: SNM:F-13790
database_cross_reference: SNMI:F-63790
database_cross_reference: SNOMEDCT_US:90086005

Psychosine
type: Class
subclass of: PMO:00020924
MCID: MC00010882
PMOID: PMO:00015700
Subclass_of: Glycosphingolipids
Synonym: Galactoside, Sphingosine
Synonym: Galactosylsphingosine
Synonym: Psychosine [Chemical/Ingredient]
Synonym: Sphingosine Galactoside
Synonym: beta-D-Galactopyranoside, 2-amino-3-hydroxy-4-octadecenyl, (R-(R*,S*-(E)))-
Tree Number: T6.9.6.2.1
database_cross_reference: FMA:82810
database_cross_reference: MSH:D011609
database_cross_reference: NDFRT:N0000168609

Benzyl Alcohols
type: Class
subclass of: Alcohols
MCID: MC00001608
PMOID: PMO:00015701
Subclass_of: Alcohols
Synonym: Alcohols, Benzyl
Synonym: Benzyl Alcohols [Chemical/Ingredient]
Synonym: Phenylcarbinols
Synonym: Phenylmethanols
Synonym: benzyl alcohols
Synonym: phenylcarbinol
Synonym: phenylcarbinol (medication)
Synonym: topical analgesics phenylcarbinol
Tree Number: T6.2.2.4
database_cross_reference: CHV:0000001805
database_cross_reference: MEDCIN:40208
database_cross_reference: MSH:D001592
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007562

Benzyl Alcohol
type: Class
subclass of: Benzyl Alcohols
MCID: MC00001607
PMOID: PMO:00015702
Subclass_of: Benzyl Alcohols
Synonym: (Hydroxymethyl)benzene
Synonym: ALCOHOL,BENZYL
Synonym: Alcohol Benzyl
Synonym: Alcohol, Benzyl
Synonym: Alcoholum benzylicum
Synonym: Alcool benzylique
Synonym: Alcoolbenzylique
Synonym: Aromatic alcohol
Synonym: BENZYL ALCOHOL
Synonym: Baby's Own Teething Gel - 2.5%
Tree Number: T6.2.2.4.1
database_cross_reference: ATC:P03AX06
database_cross_reference: CHV:0000001804
database_cross_reference: DRUGBANK:DB06770
database_cross_reference: LNC:LP18054-4
database_cross_reference: LNC:MTHU003048
database_cross_reference: MDDB:10194
database_cross_reference: MEDCIN:40232
database_cross_reference: MMSL:11807
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D019905
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:LKG8494WBH
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C77028
database_cross_reference: NCI_FDA:LKG8494WBH
database_cross_reference: NDDF:003192
database_cross_reference: NDFRT:N0000006750
database_cross_reference: NDFRT:N0000145833
database_cross_reference: NDFRT:N0000146159
database_cross_reference: RCD:X79Jg
database_cross_reference: RXNORM:1426
database_cross_reference: SNM:E-7013
database_cross_reference: SNMI:C-6B0B0
database_cross_reference: SNOMEDCT_US:256062006
database_cross_reference: SNOMEDCT_US:400850005
database_cross_reference: SNOMEDCT_US:55902002
database_cross_reference: USPMG:MTHU002572
database_cross_reference: VANDF:4017445
database_cross_reference: VANDF:4017798

Chlorohydrins
type: Class
subclass of: Alcohols
MCID: MC00002666
PMOID: PMO:00015703
Subclass_of: Alcohols
Synonym: Chlorhydrins
Synonym: Chlorohydrins [Chemical/Ingredient]
Tree Number: T6.2.2.5
database_cross_reference: MSH:D002728
database_cross_reference: NDFRT:N0000007722

alpha-Chlorohydrin
type: Class
subclass of: Chlorohydrins
MCID: MC00000636
PMOID: PMO:00015704
Subclass_of: Chlorohydrins
Synonym: 1,2-Propanediol, 3-chloro-
Synonym: 3 Chloro 1,2 propanediol
Synonym: 3 Chloropropanediol
Synonym: 3 Monochloropropane 1,2 diol
Synonym: 3-Chloro-1,2-propanediol
Synonym: 3-Chloropropanediol
Synonym: 3-MCPD
Synonym: 3-Monochloropropane-1,2-diol
Synonym: Glycerol alpha Monochlorohydrin
Synonym: Glycerol alpha-Monochlorohydrin
Tree Number: T6.2.2.5.1
database_cross_reference: MSH:D000517
database_cross_reference: NDFRT:N0000166818

Chlorobutanol
type: Class
subclass of: Chlorohydrins
subclass of: Butanols
MCID: MC00002661
PMOID: PMO:00015705
Subclass_of: Butanols
Subclass_of: Chlorohydrins
Synonym: 1,1,1-Trichloro-2-methyl-2-propanol
Synonym: 1,1,1-Trichloro-tert-butyl Alcohol
Synonym: 2-(Trichloromethyl)-2-propanol
Synonym: 2-Propanol, 1,1,1-trichloro-2-methyl-
Synonym: 2-Propanol, 2-methyl-1,1,1-trichloro-
Synonym: Acetonchloroform
Synonym: Aurisan Dps
Synonym: Balminil Nasal Ointment
Synonym: CHLOROBUTANOL
Synonym: Chlorbutol
Tree Number: T6.2.2.5.2
Tree Number: T6.9.4.2.1
database_cross_reference: ATC:A04AD04
database_cross_reference: CHV:0000002829
database_cross_reference: DRUGBANK:DB11386
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D002724
database_cross_reference: MTHSPL:HM4YQM8WRC
database_cross_reference: NCI:C65317
database_cross_reference: NCI_FDA:HM4YQM8WRC
database_cross_reference: NDDF:003205
database_cross_reference: NDDF:009289
database_cross_reference: NDFRT:N0000006881
database_cross_reference: NDFRT:N0000145875
database_cross_reference: RCD:X809W
database_cross_reference: RXNORM:2378
database_cross_reference: SNM:E-8964
database_cross_reference: SNMI:C-2A454
database_cross_reference: SNOMEDCT_US:420493005
database_cross_reference: SNOMEDCT_US:9234005
database_cross_reference: VANDF:4017487

Ethchlorvynol
type: Class
subclass of: Chlorohydrins
MCID: MC00004766
PMOID: PMO:00015706
Subclass_of: Chlorohydrins
Synonym: 1-Chloro-3-ethyl-pent-1-en-4-yn-3-ol
Synonym: 1-Penten-4-yn-3-ol, 1-chloro-3-ethyl-
Synonym: 1-chloro-3-ethyl-1-penten-4-yn-3-ol
Synonym: 3-(beta-chlorovinyl)-1-pentyn-3-ol
Synonym: 3-(β-chlorovinyl)-1-pentyn-3-ol
Synonym: Arvynol
Synonym: ETHCHLORVYNOL
Synonym: Ethchlorovynol
Synonym: Ethchlorvinol
Synonym: Ethchlorvynol (product)
Tree Number: T6.2.2.5.3
database_cross_reference: ATC:N05CM08
database_cross_reference: CHV:0000004689
database_cross_reference: DRUGBANK:DB00189
database_cross_reference: LNC:LP16135-3
database_cross_reference: LNC:MTHU013924
database_cross_reference: MEDCIN:41382
database_cross_reference: MMSL:4697
database_cross_reference: MMSL:d00226
database_cross_reference: MSH:D004984
database_cross_reference: MTH:U001907
database_cross_reference: NCI:C61758
database_cross_reference: NCI_FDA:6EIM3851UZ
database_cross_reference: NDDF:001430
database_cross_reference: NDFRT:N0000007325
database_cross_reference: NDFRT:N0000147035
database_cross_reference: RXNORM:4118
database_cross_reference: SNM:E-7871
database_cross_reference: SNMI:C-64240
database_cross_reference: SNOMEDCT_US:111126006
database_cross_reference: SNOMEDCT_US:400660004
database_cross_reference: VANDF:4018730

Fatty Alcohols
type: Class
subclass of: Alcohols
subclass of: PMO:00021062
MCID: MC00004988
PMOID: PMO:00015707
Subclass_of: Alcohols
Subclass_of: Lipids
Synonym: Alcohols, Fatty
Synonym: Fatty Alcohols [Chemical/Ingredient]
Synonym: Fatty alcohol
Synonym: Fatty alcohol (substance)
Synonym: Fatty alcohols
Synonym: alcohol fatty
Synonym: fatty alcohols
Tree Number: T6.2.2.6
Tree Number: T6.9.4
database_cross_reference: AOD:0000019723
database_cross_reference: CHV:0000004926
database_cross_reference: LCH:U001741
database_cross_reference: LCH_NW:sh85047472
database_cross_reference: MSH:D005233
database_cross_reference: NDFRT:N0000007718
database_cross_reference: SNOMEDCT_US:420151004

Pentanols
type: Class
subclass of: Fatty Alcohols
MCID: MC00000523
PMOID: PMO:00015708
Subclass_of: Fatty Alcohols
Synonym: Alcohols, Amyl
Synonym: Alcohols, Pentyl
Synonym: Amyl Alcohols
Synonym: Hydroxypentanes
Synonym: Methylbutanols
Synonym: Pentanols [Chemical/Ingredient]
Synonym: Pentyl Alcohols
Tree Number: T6.2.2.6.1
Tree Number: T6.9.4.1
database_cross_reference: MSH:D000439
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168648

Butanols
type: Class
subclass of: Fatty Alcohols
MCID: MC00000524
PMOID: PMO:00015709
Subclass_of: Fatty Alcohols
Synonym: Alcohol Butyl
Synonym: Alcohols, Butyl
Synonym: BUTANOLS
Synonym: BUTYL ALCOHOL
Synonym: Butanol
Synonym: Butanols [Chemical/Ingredient]
Synonym: Butyl Alcohol
Synonym: Butyl Alcohols
Synonym: Butyl alcohol
Synonym: Butyl alcohol (substance)
Tree Number: T6.2.2.6.2
Tree Number: T6.9.4.2
database_cross_reference: AOD:0000019702
database_cross_reference: AOD:0000028746
database_cross_reference: CHV:0000000877
database_cross_reference: CSP:0081-1411
database_cross_reference: DRUGBANK:DB02145
database_cross_reference: LCH_NW:sh85018354
database_cross_reference: LNC:LP17974-4
database_cross_reference: LNC:MTHU004528
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000440
database_cross_reference: MTH:U001673
database_cross_reference: NCI:C76700
database_cross_reference: NCI_FDA:8PJ61P6TS3
database_cross_reference: NDFRT:N0000008125
database_cross_reference: NDFRT:N0000176058
database_cross_reference: RCD:X809H
database_cross_reference: SNM:E-5523
database_cross_reference: SNMI:C-21015
database_cross_reference: SNOMEDCT_US:13531009
database_cross_reference: VANDF:4025695

1-Butanol
type: Class
subclass of: Butanols
MCID: MC00044348
PMOID: PMO:00015710
Subclass_of: Butanols
Synonym: 1 Butanol
Synonym: 1-Butanol [Chemical/Ingredient]
Synonym: ALCOHOL,BUTYL
Synonym: Alcohol, Butyl
Synonym: Alcohol, n-Butyl
Synonym: BUTANOL 001
Synonym: BUTANOL N
Synonym: BUTYL ALCOHOL
Synonym: Butan-1-ol
Synonym: Butan-1-ol (substance)
Tree Number: T6.9.4.2.2
database_cross_reference: CHV:0000016107
database_cross_reference: DRUGBANK:DB02145
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D020001
database_cross_reference: MTH:U002501
database_cross_reference: MTHSPL:8PJ61P6TS3
database_cross_reference: NDDF:007150
database_cross_reference: NDFRT:N0000168650
database_cross_reference: NDFRT:N0000176059
database_cross_reference: RCD:Xa7Nh
database_cross_reference: RXNORM:1310579
database_cross_reference: SNOMEDCT_US:299988003
database_cross_reference: VANDF:4025696

tert-Butyl Alcohol
type: Class
subclass of: Butanols
MCID: MC00038959
PMOID: PMO:00015711
Subclass_of: Butanols
Synonym: 2-Methyl-2-Propanol
Synonym: 2-Methyl-2-propanol
Synonym: Alcohol, tert-Butyl
Synonym: Alcohol, tertiary-Butyl
Synonym: TERT-BUTYL ALCOHOL
Synonym: Tert-Butyl Alcohol
Synonym: Tert-butyl Alcohol
Synonym: Tert-butyl alcohol
Synonym: t Butanol
Synonym: t-Butanol
Tree Number: T6.9.4.2.3
database_cross_reference: DRUGBANK:DB03900
database_cross_reference: LNC:LP17972-8
database_cross_reference: LNC:MTHU027270
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D020002
database_cross_reference: MTHSPL:MD83SFE959
database_cross_reference: NCI:C80660
database_cross_reference: NCI_FDA:MD83SFE959
database_cross_reference: NDFRT:N0000168651
database_cross_reference: RXNORM:1363061
database_cross_reference: SNMI:C-21017
database_cross_reference: SNOMEDCT_US:88863000

Hexanols
type: Class
subclass of: Fatty Alcohols
MCID: MC00000525
PMOID: PMO:00015712
Subclass_of: Fatty Alcohols
Synonym: Alcohols, Hexyl
Synonym: Hexanol
Synonym: Hexanol (substance)
Synonym: Hexanols [Chemical/Ingredient]
Synonym: Hexyl Alcohols
Synonym: Hydroxyhexanes
Synonym: hexanol
Synonym: hexyl alcohol
Tree Number: T6.2.2.6.3
Tree Number: T6.9.4.3
database_cross_reference: AOD:0000019706
database_cross_reference: AOD:0000028749
database_cross_reference: MSH:D000441
database_cross_reference: NDFRT:N0000008268
database_cross_reference: RCD:Xa7Nt
database_cross_reference: SNOMEDCT_US:299998009

Cyclohexanols
type: Class
subclass of: Hexanols
MCID: MC00003416
PMOID: PMO:00015713
Subclass_of: Hexanols
Synonym: Cyclohexanols [Chemical/Ingredient]
Tree Number: T6.9.4.3.1
database_cross_reference: MSH:D003511
database_cross_reference: NDFRT:N0000007891

Octanols
type: Class
subclass of: Fatty Alcohols
MCID: MC00000526
PMOID: PMO:00015718
Subclass_of: Fatty Alcohols
Synonym: Alcohols, Octyl
Synonym: Alcohols, Octylic
Synonym: Heptylcarbinols
Synonym: Hydroxyoctanes
Synonym: Octanol
Synonym: Octanol (substance)
Synonym: Octanols [Chemical/Ingredient]
Synonym: Octyl Alcohols
Synonym: Octylic Alcohols
Synonym: octanol
Tree Number: T6.2.2.6.4
Tree Number: T6.9.4.4
database_cross_reference: AOD:0000028750
database_cross_reference: CHV:0000000878
database_cross_reference: MSH:D000442
database_cross_reference: NDFRT:N0000168643
database_cross_reference: RCD:Xa7Ny
database_cross_reference: SNOMEDCT_US:300001004

1-Octanol
type: Class
subclass of: Octanols
MCID: MC00014554
PMOID: PMO:00015719
Subclass_of: Octanols
Synonym: 1 Octanol
Synonym: 1-Octanol [Chemical/Ingredient]
Synonym: Alcohol, n-Octyl
Synonym: CAPRYLIC ALCOHOL
Synonym: Caprylic Alcohol
Synonym: Caprylic alcohol
Synonym: Caprylic alcohol (substance)
Synonym: OCTANOL 01
Synonym: OCTANOL N
Synonym: n Octanol
Tree Number: T6.9.4.4.1
database_cross_reference: DRUGBANK:DB12452
database_cross_reference: MSH:D020003
database_cross_reference: MTHSPL:NV1779205D
database_cross_reference: NDFRT:N0000168644
database_cross_reference: RXNORM:1487826
database_cross_reference: SNOMEDCT_US:115617001

Dolichol
type: Class
subclass of: Fatty Alcohols
subclass of: Terpenes
MCID: MC00004142
PMOID: PMO:00015720
Subclass_of: Fatty Alcohols
Subclass_of: Terpenes
Synonym: 6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78-Octacontanonadecaen-1-ol, 3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79-eicosamethyl-
Synonym: Dolichol (substance)
Synonym: Dolichol [Chemical/Ingredient]
Synonym: dolichol
Tree Number: T6.2.17.6.4
Tree Number: T6.2.2.6.5
Tree Number: T6.9.4.5
database_cross_reference: CSP:2828-4742
database_cross_reference: LNC:LP18153-4
database_cross_reference: LNC:MTHU003488
database_cross_reference: MSH:D004286
database_cross_reference: NDFRT:N0000168646
database_cross_reference: SNOMEDCT_US:117157000

Dolichol Phosphates
type: Class
subclass of: Dolichol
MCID: MC00004145
PMOID: PMO:00015721
Subclass_of: Dolichol
Synonym: Dolichol Phosphates [Chemical/Ingredient]
Synonym: Phosphates, Dolichol
Tree Number: T6.9.4.5.1
database_cross_reference: MSH:D004288
database_cross_reference: NDFRT:N0000168647

Farnesol
type: Class
subclass of: Fatty Alcohols
MCID: MC00004965
PMOID: PMO:00015722
Subclass_of: Fatty Alcohols
Synonym: (E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
Synonym: 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-
Synonym: 3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
Synonym: FARNESOL
Synonym: FARNESOL, (2E,6E)-
Synonym: Farnesol (substance)
Synonym: Farnesol [Chemical/Ingredient]
Synonym: Farnesol, (2E,6E)-
Synonym: Farnesyl Alcohol
Synonym: Farnesyl alcohol
Tree Number: T6.2.2.6.6
Tree Number: T6.9.4.6
database_cross_reference: CHV:0000004897
database_cross_reference: DRUGBANK:DB02509
database_cross_reference: MSH:D005204
database_cross_reference: MTHSPL:EB41QIU6JL
database_cross_reference: MTHSPL:X23PI60R17
database_cross_reference: NCI:C64169
database_cross_reference: NCI_DCP:31621
database_cross_reference: NCI_FDA:X23PI60R17
database_cross_reference: NDDF:012712
database_cross_reference: NDFRT:N0000168649
database_cross_reference: RXNORM:1362903
database_cross_reference: SNOMEDCT_US:420069006

Dodecanol
type: Class
subclass of: Fatty Alcohols
MCID: MC00007400
PMOID: PMO:00015723
Subclass_of: Fatty Alcohols
Synonym: 1 Dodecanol
Synonym: 1-DODECANOL
Synonym: 1-Dodecanol
Synonym: Alcohol, Dodecyl
Synonym: Alcohol, Lauryl
Synonym: Alcohol, n-Dodecyl
Synonym: Dodecanol [Chemical/Ingredient]
Synonym: Dodecyl Alcohol
Synonym: LAURYL ALCOHOL
Synonym: Lauryl Alcohol
Tree Number: T6.2.2.6.7
Tree Number: T6.9.4.7
database_cross_reference: AOD:0000019725
database_cross_reference: DRUGBANK:DB06894
database_cross_reference: MSH:D007851
database_cross_reference: MTHSPL:178A96NLP2
database_cross_reference: NDFRT:N0000007825
database_cross_reference: RXNORM:1362875

Sodium Dodecyl Sulfate
type: Class
subclass of: Dodecanol
MCID: MC00011981
PMOID: PMO:00015724
Subclass_of: Dodecanol
Synonym: Anticerumen
Synonym: Bamboo Salt
Synonym: Bamboo Salt 160g
Synonym: Dodecyl Sulfate, Sodium
Synonym: Dr.G Hydra Intensive Moist Cleansing gel
Synonym: Emal 10
Synonym: Empicol
Synonym: For Sope
Synonym: Genapol LSS
Synonym: Lauryl Sulfate, Sodium
Tree Number: T6.9.4.7.1
database_cross_reference: AOD:0000019727
database_cross_reference: CHV:0000011486
database_cross_reference: DRUGBANK:DB00815
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D012967
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:368GB5141J
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C76733
database_cross_reference: NCI_FDA:368GB5141J
database_cross_reference: NDDF:002550
database_cross_reference: NDFRT:N0000007211
database_cross_reference: NDFRT:N0000147556
database_cross_reference: RXNORM:9871
database_cross_reference: SNOMEDCT_US:412310002
database_cross_reference: VANDF:4019424

Sodium Tetradecyl Sulfate
type: Class
subclass of: Fatty Alcohols
MCID: MC00012022
PMOID: PMO:00015725
Subclass_of: Fatty Alcohols
Synonym: 1-Tetradecanol, hydrogen sulfate, sodium salt
Synonym: 7-Ethyl-2-methyl-4-undecanol sulfate sodium salt
Synonym: 7-ethyl-2-methyl-4-undecanolsulfate, sodium salt
Synonym: Natrii tetradecylis sulfa
Synonym: SODIUM TETRADECYL SULFATE
Synonym: STD - Sodium tetradecyl
Synonym: STD - Sodium tetradecyl sulfate
Synonym: STD - Sodium tetradecyl sulphate
Synonym: STS
Synonym: Sodium 2-methyl-7-ethylundecanol-4-sulfate
Tree Number: T6.2.2.6.8
Tree Number: T6.9.4.8
database_cross_reference: AOD:0000019729
database_cross_reference: ATC:C05BB04
database_cross_reference: CHV:0000011504
database_cross_reference: DRUGBANK:DB00464
database_cross_reference: MMSL:1154
database_cross_reference: MMSL:5497
database_cross_reference: MMSL:d01383
database_cross_reference: MSH:D012981
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C66555
database_cross_reference: NCI_FDA:Q1SUG5KBD6
database_cross_reference: NDDF:002554
database_cross_reference: NDFRT:N0000007258
database_cross_reference: NDFRT:N0000147335
database_cross_reference: RCD:by2..
database_cross_reference: RCDAE:by2..
database_cross_reference: RXNORM:9913
database_cross_reference: SNMI:C-81821
database_cross_reference: SNOMEDCT_US:387320008
database_cross_reference: SNOMEDCT_US:57616006
database_cross_reference: VANDF:4019068

Heptanol
type: Class
subclass of: Fatty Alcohols
MCID: MC00032637
PMOID: PMO:00015726
Subclass_of: Fatty Alcohols
Synonym: 1 Heptanol
Synonym: 1-Heptanol
Synonym: Alcohol, Heptyl
Synonym: HEPTANOL 01
Synonym: HEPTANOL N
Synonym: Heptan-1-ol
Synonym: Heptan-1-ol (substance)
Synonym: Heptanol (substance)
Synonym: Heptanol [Chemical/Ingredient]
Synonym: Heptyl Alcohol
Tree Number: T6.2.2.6.9
Tree Number: T6.9.4.9
database_cross_reference: MSH:D019850
database_cross_reference: NDFRT:N0000168645
database_cross_reference: RCD:X80Ac
database_cross_reference: RCD:Xa7Nu
database_cross_reference: SNOMEDCT_US:259192004
database_cross_reference: SNOMEDCT_US:299999001

Acetogenins
type: Class
subclass of: Fatty Alcohols
subclass of: Lactones
subclass of: Furans
MCID: MC00510485
PMOID: PMO:00015727
Subclass_of: Fatty Alcohols
Subclass_of: Furans
Subclass_of: Lactones
Synonym: Acetogenin Compounds
Synonym: Acetogenins [Chemical/Ingredient]
Tree Number: T6.2.2.6.10
Tree Number: T6.2.21.9
Tree Number: T6.3.5.10.12
Tree Number: T6.9.4.10
database_cross_reference: MSH:D054378
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178726

Glycols
type: Class
subclass of: Alcohols
MCID: MC00005756
PMOID: PMO:00015728
Subclass_of: Alcohols
Synonym: Glycol
Synonym: Glycol (substance)
Synonym: Glycol, NOS
Synonym: Glycols [Chemical/Ingredient]
Synonym: glycol
Tree Number: T6.2.2.7
database_cross_reference: CHV:0000005619
database_cross_reference: LCH:U002008
database_cross_reference: LCH_NW:sh85055401
database_cross_reference: MSH:D006018
database_cross_reference: MTH:U001964
database_cross_reference: NDFRT:N0000008218
database_cross_reference: SNMI:C-21300
database_cross_reference: SNOMEDCT_US:52086008

Butylene Glycols
type: Class
subclass of: Glycols
MCID: MC00002045
PMOID: PMO:00015729
Subclass_of: Glycols
Synonym: BUTYLENE GLYCOL
Synonym: Butanediols
Synonym: Butylene Glycol
Synonym: Butylene Glycols [Chemical/Ingredient]
Synonym: Dihydroxybutanes
Synonym: Glycols, Butylene
Synonym: butanediol
Synonym: butylene glycol
Tree Number: T6.2.2.7.1
database_cross_reference: AOD:0000019711
database_cross_reference: CHV:0000002250
database_cross_reference: MSH:D002072
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C77457
database_cross_reference: NCI_FDA:3XUS85K0RA
database_cross_reference: NDFRT:N0000007849

Ethylene Glycols
type: Class
subclass of: Glycols
MCID: MC00004804
PMOID: PMO:00015731
Subclass_of: Glycols
Synonym: Dihydroxyethanes
Synonym: Ethanediols
Synonym: Ethylene Glycols [Chemical/Ingredient]
Synonym: Ethylene glycols
Synonym: Glycols, Ethylene
Tree Number: T6.2.2.7.2
database_cross_reference: LCH_NW:sh2006002244
database_cross_reference: MSH:D005026
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008014

Chloralose
type: Class
subclass of: PMO:00020974
MCID: MC00002633
PMOID: PMO:00015733
Subclass_of: Glucosides
Synonym: Alphachloralose
Synonym: Alphachloralose (substance)
Synonym: Anhydroglucochloral
Synonym: Chloralose [Chemical/Ingredient]
Synonym: Glucochloral
Synonym: Glucochloralose
Synonym: alpha Chloralose
Synonym: alpha Chloralose (substance)
Synonym: alpha-Chloralose
Synonym: alpha-D-Glucofuranose, 1,2-O-(2,2,2-trichloroethylidene)-, (R)-
Tree Number: T6.8.6.7.4
database_cross_reference: CHV:0000002811
database_cross_reference: MSH:D002698
database_cross_reference: NDDF:006147
database_cross_reference: NDFRT:N0000168436
database_cross_reference: PSY:08920
database_cross_reference: RCD:Xa0HT
database_cross_reference: SNMI:C-6A184
database_cross_reference: SNOMEDCT_US:277016007
database_cross_reference: SNOMEDCT_US:3389002

Polyethylene Glycols
type: Class
subclass of: Polymers
MCID: MC00010416
PMOID: PMO:00015735
Subclass_of: Polymers
Synonym: PEG
Synonym: PEG-400
Synonym: PEO-400
Synonym: POLYETHYLENE GLYCOL 400
Synonym: POLYETHYLENE GLYCOL 400 LIQUID
Synonym: POLYETHYLENE GLYCOL 400 [VA Product]
Synonym: POLYETHYLENE GLYCOLS
Synonym: Peg
Synonym: Peg 400
Synonym: Poly(oxyethylene)
Tree Number: T6.14.9.9
Tree Number: T6.5.2.11
database_cross_reference: CHV:0000009914
database_cross_reference: DRUGBANK:DB11077
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:C000595213
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:B697894SGQ
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C762
database_cross_reference: NCI:C84080
database_cross_reference: NCI_DCP:03226
database_cross_reference: NCI_FDA:3WJQ0SDW1A
database_cross_reference: NCI_FDA:B697894SGQ
database_cross_reference: NCI_NCI-GLOSS:CDR0000643074
database_cross_reference: NDDF:007839
database_cross_reference: NDFRT:N0000145793
database_cross_reference: NDFRT:N0000148316
database_cross_reference: NDFRT:N0000158423
database_cross_reference: RXNORM:8514
database_cross_reference: VANDF:4010510
database_cross_reference: VANDF:4020744
database_cross_reference: VANDF:4024435

Cetomacrogol
type: Class
subclass of: Polyethylene Glycols
MCID: MC00002566
PMOID: PMO:00015736
Subclass_of: Polyethylene Glycols
Synonym: Cetomacrogol (substance)
Synonym: Cetomacrogol [Chemical/Ingredient]
Synonym: Poly(oxy-1,2-ethanediyl), alpha-hexadecyl-omega-hydroxy-
Synonym: Polyethylene Glycol Cetyl Ether
Synonym: Polyethylene Glycol Monohexadecyl Ether
Synonym: alpha-Hexadecyl-omega-Hydroxypoly(oxy-1,2-Ethanediyl)
Synonym: cetomacrogol
Synonym: n Hexadecane Polyoxyethylene Glycol Monether
Synonym: n-Hexadecane Polyoxyethylene Glycol Monether
Tree Number: T6.14.9.9.1
Tree Number: T6.5.2.11.2
database_cross_reference: CHV:0000002708
database_cross_reference: MSH:D002592
database_cross_reference: NCI:C84073
database_cross_reference: NDFRT:N0000171522
database_cross_reference: SNOMEDCT_US:396448001

Poloxalene
type: Class
subclass of: Polyethylene Glycols
MCID: MC00010380
PMOID: PMO:00015737
Subclass_of: Polyethylene Glycols
Synonym: Oxyethylene Oxypropylene Polymer
Synonym: Oxypropylene Polymer, Oxyethylene
Synonym: POLOXALENE
Synonym: Poloxalene (substance)
Synonym: Poloxalene [Chemical/Ingredient]
Synonym: Polyethylene-polypropylene glycol
Synonym: Polymer, Oxyethylene Oxypropylene
Synonym: Polyoxyethylene Polyoxypropylene Polyoxyethylene Polymer
Synonym: poloxalene
Tree Number: T6.14.9.9.2
Tree Number: T6.5.2.11.3
database_cross_reference: CSP:2188-3197
database_cross_reference: MSH:D011060
database_cross_reference: MTHSPL:V8B3K56SW0
database_cross_reference: NCI:C84069
database_cross_reference: NCI_FDA:V8B3K56SW0
database_cross_reference: NDDF:014081
database_cross_reference: NDFRT:N0000171521
database_cross_reference: RXNORM:1314414
database_cross_reference: SNMI:C-22632
database_cross_reference: SNOMEDCT_US:95988006

Polyhydroxyethyl Methacrylate
type: Class
subclass of: Polyethylene Glycols
MCID: MC00010428
PMOID: PMO:00015738
Subclass_of: Polyethylene Glycols
Synonym: 2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, homopolymer
Synonym: Gel, Glycol Methacrylate
Synonym: Gel, Hydroxymethacrylate
Synonym: Glycol Methacrylate Gel
Synonym: Hydroxymethacrylate Gel
Synonym: Methacrylate Gel, Glycol
Synonym: Methacrylate, Polyglycol
Synonym: Methacrylate, Polyhydroxyethyl
Synonym: PHEMA
Synonym: Poly Hema
Tree Number: T6.14.9.9.3
Tree Number: T6.5.2.11.4
database_cross_reference: MSH:D011102
database_cross_reference: NDFRT:N0000171547

Polysorbates
type: Class
subclass of: Polyethylene Glycols
MCID: MC00010471
PMOID: PMO:00015739
Subclass_of: Polyethylene Glycols
Synonym: Monolaurate, Polyoxyethylene Sorbitan
Synonym: POLYSORBATE
Synonym: PSML
Synonym: Polyoxyethylene Sorbitan Monolaurate
Synonym: Polysorbate
Synonym: Polysorbate (product)
Synonym: Polysorbate (substance)
Synonym: Polysorbate ester
Synonym: Polysorbates [Chemical/Ingredient]
Synonym: Sorbitan Monolaurate, Polyoxyethylene
Tree Number: T6.14.9.9.4
Tree Number: T6.5.2.11.5
database_cross_reference: AOD:0000019718
database_cross_reference: CHV:0000009945
database_cross_reference: DRUGBANK:DB11063
database_cross_reference: MSH:D011136
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NDDF:002551
database_cross_reference: NDFRT:N0000007478
database_cross_reference: NDFRT:N0000148239
database_cross_reference: RXNORM:8561
database_cross_reference: SNOMEDCT_US:412166009
database_cross_reference: SNOMEDCT_US:412167000
database_cross_reference: VANDF:4020520

Nonoxynol
type: Class
subclass of: Polyethylene Glycols
MCID: MC00033381
PMOID: PMO:00015740
Subclass_of: Polyethylene Glycols
Synonym: NONOXYNOL
Synonym: Nonoxinol
Synonym: Nonoxinol (product)
Synonym: Nonoxinol (substance)
Synonym: Nonoxinols
Synonym: Nonoxynol (substance)
Synonym: Nonoxynol [Chemical/Ingredient]
Synonym: Nonoxynols
Synonym: Nonylphenoxypolyethoxyethanol
Synonym: Nonylphenoxypolyethoxyethanols
Tree Number: T6.14.9.9.5
Tree Number: T6.5.2.11.6
database_cross_reference: CHV:0000014511
database_cross_reference: MSH:D017137
database_cross_reference: NDDF:007492
database_cross_reference: NDFRT:N0000006214
database_cross_reference: NDFRT:N0000147216
database_cross_reference: RCD:gb1..
database_cross_reference: SNOMEDCT_US:326454008
database_cross_reference: SNOMEDCT_US:397179004
database_cross_reference: VANDF:4018924

Octoxynol
type: Class
subclass of: Polyethylene Glycols
MCID: MC00033722
PMOID: PMO:00015741
Subclass_of: Polyethylene Glycols
Synonym: Anapoe-305
Synonym: Octoxinol
Synonym: Octoxinol (product)
Synonym: Octoxinol (substance)
Synonym: Octoxinols
Synonym: Octoxynol (substance)
Synonym: Octoxynol [Chemical/Ingredient]
Synonym: Octoxynols
Synonym: Octylphenoxy Polyethoxyethanol
Synonym: Octylphenoxy polyethoxyethanol
Tree Number: T6.14.9.9.6
Tree Number: T6.5.2.11.7
database_cross_reference: CHV:0000014532
database_cross_reference: DRUGBANK:DB04682
database_cross_reference: MEDCIN:41427
database_cross_reference: MMSL:5195
database_cross_reference: MSH:D017830
database_cross_reference: NDFRT:N0000007486
database_cross_reference: RCD:gb2..
database_cross_reference: RXNORM:32301
database_cross_reference: SNOMEDCT_US:326485004
database_cross_reference: SNOMEDCT_US:418139001
database_cross_reference: SNOMEDCT_US:419217003

Hydrogel, Polyethylene Glycol Dimethacrylate
type: Class
subclass of: Polyethylene Glycols
PMOID: PMO:00015742
Subclass_of: Polyethylene Glycols
Tree Number: T6.14.9.9.7
Tree Number: T6.5.2.11.8

Poloxamer
type: Class
subclass of: Polyethylene Glycols
MCID: MC00184396
PMOID: PMO:00015743
Subclass_of: Polyethylene Glycols
Synonym: POLOXAMER
Synonym: Poloxamer [Chemical/Ingredient]
Synonym: alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene)a block copolymer
Synonym: poloxamer
Tree Number: T6.14.9.9.8
Tree Number: T6.5.2.11.9
database_cross_reference: CHV:0000042319
database_cross_reference: MSH:D020442
database_cross_reference: NDDF:001178
database_cross_reference: NDFRT:N0000005921
database_cross_reference: NDFRT:N0000147367
database_cross_reference: RXNORM:155156
database_cross_reference: VANDF:4019115

Propylene Glycols
type: Class
subclass of: Glycols
MCID: MC00010703
PMOID: PMO:00015745
Subclass_of: Glycols
Synonym: Glycols, Propylene
Synonym: Propanediols
Synonym: Propylene Glycols [Chemical/Ingredient]
Tree Number: T6.2.2.7.3
database_cross_reference: MSH:D011409
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007665

Chloramphenicol
type: Class
subclass of: Nitrobenzenes
MCID: MC00002635
PMOID: PMO:00015746
Subclass_of: Nitrobenzenes
Synonym: 528 CHLORAMPHENICOLS
Synonym: Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R*,R*))-
Synonym: Actinac Pwr
Synonym: Actinac Pws
Synonym: Brochlor
Synonym: CHLORAMPHENICOL
Synonym: CHLORAMPHENICOLS
Synonym: Cebenicol Oph Liq 0.4%
Synonym: Chloramphenicol (class of antibiotic)
Synonym: Chloramphenicol (class of antibiotic, substance)
Tree Number: T6.2.25.3.1
database_cross_reference: AOD:0000019720
database_cross_reference: ATC:D06AX02
database_cross_reference: ATC:D10AF03
database_cross_reference: ATC:G01AA05
database_cross_reference: ATC:J01BA01
database_cross_reference: ATC:S01AA01
database_cross_reference: ATC:S02AA01
database_cross_reference: ATC:S03AA08
database_cross_reference: CHV:0000002814
database_cross_reference: CHV:0000045151
database_cross_reference: CSP:0194-6047
database_cross_reference: DRUGBANK:DB00446
database_cross_reference: LCH_NW:sh85024570
database_cross_reference: LNC:LP15321-0
database_cross_reference: LNC:MTHU004842
database_cross_reference: MEDCIN:40284
database_cross_reference: MMSL:3887
database_cross_reference: MMSL:4406
database_cross_reference: MMSL:d00025
database_cross_reference: MSH:D002701
database_cross_reference: MTH:U001803
database_cross_reference: MTHSPL:66974FR9Q1
database_cross_reference: NCI:C363
database_cross_reference: NCI_DCP:00420
database_cross_reference: NCI_DTP:NSC0003069
database_cross_reference: NCI_FDA:66974FR9Q1
database_cross_reference: NDDF:002767
database_cross_reference: NDFRT:N0000006813
database_cross_reference: NDFRT:N0000146533
database_cross_reference: RCD:XM0lE
database_cross_reference: RCD:eb2..
database_cross_reference: RCD:k32..
database_cross_reference: RCD:l31..
database_cross_reference: RCD:mc1..
database_cross_reference: RCD:x02Lt
database_cross_reference: RXNORM:2348
database_cross_reference: SNM:E-7204
database_cross_reference: SNMI:C-52800
database_cross_reference: SNOMEDCT_US:105907002
database_cross_reference: SNOMEDCT_US:273949002
database_cross_reference: SNOMEDCT_US:324291001
database_cross_reference: SNOMEDCT_US:330285002
database_cross_reference: SNOMEDCT_US:330915003
database_cross_reference: SNOMEDCT_US:332767001
database_cross_reference: SNOMEDCT_US:372777009
database_cross_reference: SNOMEDCT_US:57191001
database_cross_reference: USPMG:MTHU000235
database_cross_reference: VANDF:4018199

Polyvinyl Alcohol
type: Class
subclass of: Alcohols
MCID: MC00010480
PMOID: PMO:00015753
Subclass_of: Alcohols
Synonym: Alcohol Polyvinyl
Synonym: Alcohol, Polyvinyl
Synonym: Ethenol homopolymer
Synonym: Ethenol, homopolymer
Synonym: POLYVINYL ALCOHOL
Synonym: POLYVINYL ALCOHOL, UNSPECIFIED
Synonym: POLYVINYL ALCOHOl
Synonym: PVA
Synonym: PVA - Polyvinyl alcohol
Synonym: Polydesis
Tree Number: T6.2.2.8
database_cross_reference: CHV:0000009951
database_cross_reference: DRUGBANK:DB11060
database_cross_reference: LCH_NW:sh91003332
database_cross_reference: MEDCIN:199343
database_cross_reference: MMSL:60685
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D011142
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:532B59J990
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C29370
database_cross_reference: NCI_FDA:532B59J990
database_cross_reference: NDDF:002533
database_cross_reference: NDFRT:N0000005699
database_cross_reference: NDFRT:N0000147643
database_cross_reference: RCD:ka4..
database_cross_reference: RXNORM:8570
database_cross_reference: SNMI:C-2A310
database_cross_reference: SNOMEDCT_US:330790003
database_cross_reference: SNOMEDCT_US:83619009
database_cross_reference: VANDF:4019529

Sugar Alcohols
type: Class
subclass of: Alcohols
subclass of: PMO:00020868
MCID: MC00012351
PMOID: PMO:00015754
Subclass_of: Alcohols
Subclass_of: Carbohydrates
Synonym: Alcohols, Sugar
Synonym: Alditols
Synonym: Sugar Alcohols [Chemical/Ingredient]
Synonym: Sugar alcohol
Synonym: Sugar alcohol (substance)
Synonym: Sugar alcohols
Synonym: alcohol sugar
Synonym: alcohol sugars
Synonym: sugar alcohol
Synonym: sugar alcohols
Tree Number: T6.2.2.9
Tree Number: T6.8.9
database_cross_reference: AOD:0000019730
database_cross_reference: CHV:0000011839
database_cross_reference: CSP:2828-4553
database_cross_reference: LNC:LP64092-7
database_cross_reference: MSH:D013402
database_cross_reference: NDFRT:N0000008029
database_cross_reference: RCD:Ub09C
database_cross_reference: SNOMEDCT_US:116267009

Triose Sugar Alcohols
type: Class
subclass of: Sugar Alcohols
PMOID: PMO:00015755
Subclass_of: Sugar Alcohols
Tree Number: T6.2.2.9.1
Tree Number: T6.8.9.1

Glycerol
type: Class
subclass of: Triose Sugar Alcohols
MCID: MC00005724
PMOID: PMO:00015756
Subclass_of: Triose Sugar Alcohols
Synonym: 1,2,3-Propanetriol
Synonym: 1,2,3-Trihydroxypropane
Synonym: 1,2,3-propanetriol
Synonym: 1,2,3-trihydroxypropane
Synonym: 2x First Essence
Synonym: 3 en 1 Cleanser. Deep Cleansing
Synonym: 3D Lifting
Synonym: 3ce Liqu Id Eye Liner Black
Synonym: 3ce Liqu Id Eye Liner Brown
Synonym: 7 Select Redness Relief
Tree Number: T6.8.9.1.1
database_cross_reference: AOD:0000019731
database_cross_reference: AOD:0000028752
database_cross_reference: AOD:0000028755
database_cross_reference: ATC:A06AG04
database_cross_reference: ATC:A06AX01
database_cross_reference: CHV:0000005599
database_cross_reference: CSP:2997-3616
database_cross_reference: DRUGBANK:DB09462
database_cross_reference: LCH:U002004
database_cross_reference: LCH_NW:sh85055393
database_cross_reference: LNC:LP15619-7
database_cross_reference: LNC:MTHU011557
database_cross_reference: MEDCIN:250642
database_cross_reference: MEDCIN:48567
database_cross_reference: MMSL:108842
database_cross_reference: MMSL:4792
database_cross_reference: MMSL:52080
database_cross_reference: MMSL:602
database_cross_reference: MMSL:d00652
database_cross_reference: MSH:D005990
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: MTHSPL:PDC6A3C0OX
database_cross_reference: NCI:C29077
database_cross_reference: NCI_DCP:00947
database_cross_reference: NCI_FDA:PDC6A3C0OX
database_cross_reference: NDDF:001176
database_cross_reference: NDDF:001893
database_cross_reference: NDDF:002240
database_cross_reference: NDDF:002291
database_cross_reference: NDDF:002469
database_cross_reference: NDDF:004085
database_cross_reference: NDFRT:N0000006566
database_cross_reference: NDFRT:N0000145799
database_cross_reference: RCD:Ua20d
database_cross_reference: RCD:X80KY
database_cross_reference: RCD:x0055
database_cross_reference: RXNORM:4910
database_cross_reference: SNM:E-8040
database_cross_reference: SNM:F-11640
database_cross_reference: SNMI:C-96060
database_cross_reference: SNMI:F-61640
database_cross_reference: SNOMEDCT_US:225749008
database_cross_reference: SNOMEDCT_US:259474004
database_cross_reference: SNOMEDCT_US:346459006
database_cross_reference: SNOMEDCT_US:387330004
database_cross_reference: SNOMEDCT_US:404833002
database_cross_reference: SNOMEDCT_US:59018003
database_cross_reference: SNOMEDCT_US:80582002
database_cross_reference: VANDF:4017411

Glycerophosphates
type: Class
subclass of: Triose Sugar Alcohols
subclass of: PMO:00021046
subclass of: PMO:00021218
MCID: MC00005729
PMOID: PMO:00015757
Subclass_of: Phospholipids
Subclass_of: Sugar Phosphates
Subclass_of: Triose Sugar Alcohols
Synonym: Glycerolphosphates
Synonym: Glycerophosphates [Chemical/Ingredient]
Synonym: glycerophosphate
Tree Number: T6.8.10.2
Tree Number: T6.8.9.1.2
Tree Number: T6.9.11.2.1
database_cross_reference: AOD:0000020019
database_cross_reference: CSP:2997-4240
database_cross_reference: MSH:D005994
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000006571

Glyceryl Ethers
type: Class
subclass of: Ethers
MCID: MC00005730
PMOID: PMO:00015759
Subclass_of: Ethers
Synonym: Ethers, Glycerol
Synonym: Ethers, Glyceryl
Synonym: Glycerol Ethers
Synonym: Glyceryl Ethers [Chemical/Ingredient]
Synonym: Glyceryl ethers
Synonym: glyceryl ether
Tree Number: T6.2.14.5
database_cross_reference: AOD:0000019766
database_cross_reference: CSP:2997-3616
database_cross_reference: LCH_NW:sh97007072
database_cross_reference: MSH:D005995
database_cross_reference: NDFRT:N0000166836

Phospholipid Ethers
type: Class
subclass of: Glyceryl Ethers
MCID: MC00010134
PMOID: PMO:00015760
Subclass_of: Glyceryl Ethers
Synonym: Ether Phosphatidates
Synonym: Ether Phospholipids
Synonym: Ethers, Glycerol Phosphate
Synonym: Ethers, Glycerophosphate
Synonym: Ethers, Phospholipid
Synonym: Glycerol Phosphate Ethers
Synonym: Glycerophosphate Ethers
Synonym: Phosphate Ethers, Glycerol
Synonym: Phosphatidates, Ether
Synonym: Phospholipid Ethers [Chemical/Ingredient]
Tree Number: T6.2.14.5.1
database_cross_reference: AOD:0000020028
database_cross_reference: MSH:D010742
database_cross_reference: NDFRT:N0000168628

Dithioerythritol
type: Class
subclass of: Sugar Alcohols
subclass of: Thioglycosides
MCID: MC00004076
PMOID: PMO:00015761
Subclass_of: Sugar Alcohols
Subclass_of: Thioglycosides
Synonym: (2R*,3S*)-1,4-dimercapto-2,3-butanediol
Synonym: (2R,3S)-1,4-dimercaptobutane-2,3-diol
Synonym: 1,4-dithioerythritol
Synonym: 2,3-Butanediol, 1,4-dimercapto-, (R*,S*)-
Synonym: DTE
Synonym: Dithioerythreitol
Synonym: Dithioerythritol [Chemical/Ingredient]
Synonym: erythro-1,4-Dimercapto-2,3-butanediol
Tree Number: T6.2.2.9.2
Tree Number: T6.2.32.18.1
Tree Number: T6.8.9.2
database_cross_reference: DRUGBANK:DB01692
database_cross_reference: MSH:D004226
database_cross_reference: NDFRT:N0000168414

Dithiothreitol
type: Class
subclass of: Sugar Alcohols
subclass of: Thioglycosides
MCID: MC00004079
PMOID: PMO:00015762
Subclass_of: Sugar Alcohols
Subclass_of: Thioglycosides
Synonym: 1,4-Dithiothreitol
Synonym: 2,3-Butanediol, 1,4-dimercapto-, (R*,R*)-
Synonym: 2,3-dihydroxy-1,4-dithiobutane
Synonym: Cleland Reagent
Synonym: Cleland's Reagent
Synonym: Clelands Reagent
Synonym: DITHIOTHREITOL
Synonym: DTT
Synonym: Dithiothreitol [Chemical/Ingredient]
Synonym: Reagent, Cleland
Tree Number: T6.2.2.9.3
Tree Number: T6.2.32.18.2
Tree Number: T6.8.9.3
database_cross_reference: DRUGBANK:DB04447
database_cross_reference: MSH:D004229
database_cross_reference: NCI:C76286
database_cross_reference: NCI_FDA:T8ID5YZU6Y
database_cross_reference: NDFRT:N0000168413

Galactitol
type: Class
subclass of: Sugar Alcohols
MCID: MC00004203
PMOID: PMO:00015763
Subclass_of: Sugar Alcohols
Synonym: Galactitol (substance)
Synonym: Galactitol [Chemical/Ingredient]
Synonym: galactitol
Tree Number: T6.2.2.9.4
Tree Number: T6.8.9.4
database_cross_reference: CSP:2828-4553
database_cross_reference: FMA:82791
database_cross_reference: LNC:LP61820-4
database_cross_reference: LNC:MTHU026383
database_cross_reference: MSH:D004376
database_cross_reference: NCI:C425
database_cross_reference: NDFRT:N0000168409
database_cross_reference: PDQ:CDR0000039215
database_cross_reference: RCD:X80Hq
database_cross_reference: SNOMEDCT_US:116268004

Dianhydrogalactitol
type: Class
subclass of: Galactitol
MCID: MC00003815
PMOID: PMO:00015764
Subclass_of: Galactitol
Synonym: 1,2,5,6 dianhydrogalactitol
Synonym: 1,2,5,6-Dianhydrogalactitol
Synonym: 1,2:5, 6-Dianhydrogalactitol
Synonym: 1,2:5, 6-diepoxydulcitol
Synonym: 1,2:5,6 dianhydrogalactitol
Synonym: 1,2:5,6-Dianhydrodulcitol
Synonym: 1,2:5,6-Diepoxydulcitol
Synonym: 1,2:5,6-dianhydrodulcitol
Synonym: DAG
Synonym: Dianhydrodulcitol
Tree Number: T6.8.9.4.1
database_cross_reference: DRUGBANK:DB12873
database_cross_reference: MSH:D003961
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C425
database_cross_reference: NCI_DTP:NSC0132313
database_cross_reference: NDFRT:N0000168410
database_cross_reference: PDQ:CDR0000039215

Mitolactol
type: Class
subclass of: Galactitol
MCID: MC00008352
PMOID: PMO:00015765
Subclass_of: Galactitol
Synonym: 6-Dibromodideoxydulcitol
Synonym: 6-Dibromodulcitol
Synonym: 6-dibromodideoxydulcitol
Synonym: 6-dibromodulcitol
Synonym: DBD
Synonym: Dibromdicil
Synonym: Dibromodulcitol
Synonym: Galactitol, 1,6-dibromo-1,6-dideoxy-
Synonym: MITOLACTOL
Synonym: Mitolactol [Chemical/Ingredient]
Tree Number: T6.8.9.4.2
database_cross_reference: CHV:0000008185
database_cross_reference: DRUGBANK:DB12916
database_cross_reference: MSH:D008936
database_cross_reference: NCI:C662
database_cross_reference: NCI_DTP:NSC0104800
database_cross_reference: NCI_FDA:LJ2P1SIK8Y
database_cross_reference: NCI_NCI-GLOSS:CDR0000045191
database_cross_reference: NDFRT:N0000168411
database_cross_reference: PDQ:CDR0000039216

Erythritol
type: Class
subclass of: Sugar Alcohols
MCID: MC00004671
PMOID: PMO:00015766
Subclass_of: Sugar Alcohols
Synonym: 1,2,3,4-Butanetetrol, (R*,S*)-
Synonym: ERYTHRITOL
Synonym: Erythritol (substance)
Synonym: Erythritol [Chemical/Ingredient]
Synonym: erythritol
Tree Number: T6.2.2.9.5
Tree Number: T6.8.9.5
database_cross_reference: LNC:LP62166-1
database_cross_reference: MSH:D004896
database_cross_reference: MTHSPL:RA96B954X6
database_cross_reference: NDDF:010760
database_cross_reference: NDFRT:N0000007625
database_cross_reference: NDFRT:N0000185380
database_cross_reference: RXNORM:1369563
database_cross_reference: SNOMEDCT_US:444471000124101
database_cross_reference: VANDF:4031612

Erythrityl Tetranitrate
type: Class
subclass of: Nitrates
subclass of: Erythritol
MCID: MC00004672
PMOID: PMO:00015767
Subclass_of: Erythritol
Subclass_of: Nitrates
Synonym: (2R*,3S)-rel-1,2,3,4-butanetetroltetranitrate
Synonym: 1,2,3,4-Butanetetralyl tetranitrate
Synonym: 1,2,3,4-Butanetetrol, Tetranitrate, (R*,S*)-
Synonym: 1,2,3,4-Butanetetrol, tetranitrate, (R*,S*)-
Synonym: ERYTHRITYL TETRANITRATE
Synonym: ETN
Synonym: Eritrityl Tetranitrate
Synonym: Eritrityl tetranitrate
Synonym: Eritrityli tetranitras
Synonym: Erythritol Tetranitrate
Tree Number: T6.2.22.1
Tree Number: T6.8.9.5.1
database_cross_reference: ATC:C01DA13
database_cross_reference: DRUGBANK:DB01613
database_cross_reference: MEDCIN:40537
database_cross_reference: MSH:D004897
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87282
database_cross_reference: NCI_FDA:35X333P19D
database_cross_reference: NDDF:000685
database_cross_reference: NDFRT:N0000006404
database_cross_reference: NDFRT:N0000147067
database_cross_reference: RXNORM:4040
database_cross_reference: SNM:E-7693
database_cross_reference: SNMI:C-81540
database_cross_reference: SNOMEDCT_US:398960003
database_cross_reference: SNOMEDCT_US:62368002
database_cross_reference: VANDF:4018764

Inositol
type: Class
subclass of: Sugar Alcohols
MCID: MC00006879
PMOID: PMO:00015768
Subclass_of: Sugar Alcohols
Synonym: Anti-alopecia factor
Synonym: Biosculpt
Synonym: Chiro Inositol
Synonym: Chiro-Inositol
Synonym: Cyclohexanehexol
Synonym: INOSITOL
Synonym: Inose
Synonym: Inositol (substance)
Synonym: Inositol [Chemical/Ingredient]
Synonym: Inositol preparation
Tree Number: T6.2.2.9.6
Tree Number: T6.8.9.6
database_cross_reference: AOD:0000019733
database_cross_reference: ATC:A11HA07
database_cross_reference: CHV:0000006754
database_cross_reference: CHV:0000041658
database_cross_reference: CSP:2828-5087
database_cross_reference: DRUGBANK:DB13178
database_cross_reference: FMA:82800
database_cross_reference: LCH:U002446
database_cross_reference: LCH_NW:sh85066543
database_cross_reference: LNC:LP64093-5
database_cross_reference: MEDCIN:41266
database_cross_reference: MMSL:4879
database_cross_reference: MMSL:5751
database_cross_reference: MMSL:d00496
database_cross_reference: MSH:D007294
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:4L6452S749
database_cross_reference: NCI:C28163
database_cross_reference: NCI_DCP:01001
database_cross_reference: NCI_FDA:4L6452S749
database_cross_reference: NCI_NCI-GLOSS:CDR0000044134
database_cross_reference: NCI_NCI-GLOSS:CDR0000629166
database_cross_reference: NDDF:002057
database_cross_reference: NDFRT:N0000007204
database_cross_reference: NDFRT:N0000146062
database_cross_reference: PDQ:CDR0000305828
database_cross_reference: RCD:Ub09T
database_cross_reference: RCD:x01PO
database_cross_reference: RXNORM:5833
database_cross_reference: SNM:F-11990
database_cross_reference: SNMI:F-61A90
database_cross_reference: SNOMEDCT_US:108960004
database_cross_reference: SNOMEDCT_US:386946007
database_cross_reference: SNOMEDCT_US:72164009
database_cross_reference: VANDF:4017688

Inositol Phosphates
type: Class
subclass of: Inositol
subclass of: PMO:00021046
MCID: MC00006882
PMOID: PMO:00015769
Subclass_of: Inositol
Subclass_of: Sugar Phosphates
Synonym: Inositol Phosphates [Chemical/Ingredient]
Synonym: Inositol phosphates
Synonym: Phosphates, Inositol
Synonym: inositol phosphate
Tree Number: T6.8.10.4
Tree Number: T6.8.9.6.1
database_cross_reference: AOD:0000019734
database_cross_reference: CSP:2828-5164
database_cross_reference: LCH_NW:sh89001804
database_cross_reference: MSH:D007295
database_cross_reference: NDFRT:N0000008091

Phytic Acid
type: Class
subclass of: Inositol Phosphates
MCID: MC00010189
PMOID: PMO:00015770
Subclass_of: Inositol Phosphates
Synonym: Acid, Phytic
Synonym: FYTIC ACID
Synonym: Fytic Acid
Synonym: Hexakisphosphate, Inositol
Synonym: Hexaphosphate, Inositol
Synonym: IP6
Synonym: Inositol Hexakisphosphate
Synonym: Inositol Hexaphosphate
Synonym: Myo-Inosistol Hexakisphosphate
Synonym: Myo-Inositol Hexakis(Dihydrogen Phosphate)
Tree Number: T6.8.10.4.1
database_cross_reference: CHV:0000009718
database_cross_reference: LCH:U003670
database_cross_reference: LCH_NW:sh85101685
database_cross_reference: MSH:D010833
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7IGF0S7R8I
database_cross_reference: NCI:C87652
database_cross_reference: NCI_FDA:7IGF0S7R8I
database_cross_reference: NCI_NCI-GLOSS:CDR0000044155
database_cross_reference: NCI_NCI-GLOSS:CDR0000044414
database_cross_reference: NCI_NCI-GLOSS:CDR0000044415
database_cross_reference: NDDF:005858
database_cross_reference: NDDF:007838
database_cross_reference: NDFRT:N0000006019
database_cross_reference: RXNORM:8302

Inositol 1,4,5-Trisphosphate
type: Class
subclass of: Inositol Phosphates
MCID: MC00006880
PMOID: PMO:00015771
Subclass_of: Inositol Phosphates
Synonym: (H super 3) inositol triphosphate
Synonym: 1 4 5 INSP3
Synonym: 1 4 5 IP3
Synonym: 1,4,5-IP3
Synonym: 1,4,5-InsP3
Synonym: 1,4,5-Insp3
Synonym: 1D-myo-inositol 1,4,5-trisphosphate
Synonym: D-myo-Inositol 1,4,5-trisphosphate
Synonym: D-myo-Inositol, 1,4,5-tris(dihydrogen phosphate)
Synonym: D-myo-Inositol-1,4,5-triphosphate
Tree Number: T6.8.10.4.2
database_cross_reference: AOD:0000019748
database_cross_reference: AOD:0000028763
database_cross_reference: AOD:0000028764
database_cross_reference: AOD:0000028767
database_cross_reference: AOD:0000028769
database_cross_reference: DRUGBANK:DB03401
database_cross_reference: MSH:D015544
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C580
database_cross_reference: NDFRT:N0000168540

Mannitol
type: Class
subclass of: Sugar Alcohols
MCID: MC00007891
PMOID: PMO:00015772
Subclass_of: Sugar Alcohols
Synonym: (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
Synonym: (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
Synonym: Additive Solution Sodium Adenine Glucose Mannitol (sagm)
Synonym: Anol
Synonym: Bronchitol
Synonym: Cordycepic acid
Synonym: Cystosol W 3% Hexitols
Synonym: D-(-)-Mannitol
Synonym: D-Mannitol
Synonym: D-mannitol
Tree Number: T6.2.2.9.7
Tree Number: T6.8.9.7
database_cross_reference: AOD:0000019752
database_cross_reference: ATC:A06AD16
database_cross_reference: ATC:B05BC01
database_cross_reference: ATC:B05CX04
database_cross_reference: ATC:R05CB16
database_cross_reference: CHV:0000007731
database_cross_reference: CSP:2828-5241
database_cross_reference: DRUGBANK:DB00742
database_cross_reference: LCH_NW:sh2008008250
database_cross_reference: LNC:LP15722-9
database_cross_reference: LNC:LP173649-7
database_cross_reference: LNC:MTHU015736
database_cross_reference: MEDCIN:40618
database_cross_reference: MMSL:5022
database_cross_reference: MMSL:7928
database_cross_reference: MMSL:d00282
database_cross_reference: MSH:D008353
database_cross_reference: MTHSPL:3OWL53L36A
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C625
database_cross_reference: NCI_DCP:03076
database_cross_reference: NCI_FDA:3OWL53L36A
database_cross_reference: NCI_NCI-GLOSS:CDR0000468771
database_cross_reference: NDDF:002272
database_cross_reference: NDDF:004521
database_cross_reference: NDFRT:N0000007229
database_cross_reference: NDFRT:N0000146108
database_cross_reference: PDQ:CDR0000039493
database_cross_reference: RCD:XM0l6
database_cross_reference: RCD:b61..
database_cross_reference: RXNORM:6628
database_cross_reference: SNM:E-889Y
database_cross_reference: SNMI:C-72050
database_cross_reference: SNOMEDCT_US:273946009
database_cross_reference: SNOMEDCT_US:30761007
database_cross_reference: SNOMEDCT_US:387168006
database_cross_reference: VANDF:4017741

Mannitol Phosphates
type: Class
subclass of: Mannitol
subclass of: PMO:00021046
MCID: MC00007893
PMOID: PMO:00015773
Subclass_of: Mannitol
Subclass_of: Sugar Phosphates
Synonym: Mannitol Phosphates [Chemical/Ingredient]
Synonym: Phosphates, Mannitol
Tree Number: T6.8.10.5
Tree Number: T6.8.9.7.1
database_cross_reference: MSH:D008355
database_cross_reference: NDFRT:N0000168554

Mitobronitol
type: Class
subclass of: Mannitol
MCID: MC00008342
PMOID: PMO:00015774
Subclass_of: Mannitol
Synonym: 1,6-Dibromo-1,6-dideoxy-D-mannitol
Synonym: D-Mannitol, 1,6-dibromo-1,6-dideoxy-
Synonym: DBM
Synonym: Dibromomannitol
Synonym: Dibromomannitol (product)
Synonym: Dibromomannitol (substance)
Synonym: MITOBRONITOL
Synonym: Mitobronitol (substance)
Synonym: Mitobronitol [Chemical/Ingredient]
Synonym: mitobronitol
Tree Number: T6.8.9.7.2
database_cross_reference: ATC:L01AX01
database_cross_reference: MSH:D008927
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C659
database_cross_reference: NCI_DTP:NSC0094100
database_cross_reference: NCI_FDA:5UP30YED7N
database_cross_reference: NDDF:004464
database_cross_reference: NDFRT:N0000168408
database_cross_reference: RCD:h1a..
database_cross_reference: RXNORM:6996
database_cross_reference: SNM:E-8382
database_cross_reference: SNMI:C-78295
database_cross_reference: SNOMEDCT_US:29089004
database_cross_reference: SNOMEDCT_US:387156002
database_cross_reference: SNOMEDCT_US:395797000

Ribitol
type: Class
subclass of: Sugar Alcohols
MCID: MC00011377
PMOID: PMO:00015775
Subclass_of: Sugar Alcohols
Synonym: Adonitol
Synonym: Ribitol (substance)
Synonym: Ribitol [Chemical/Ingredient]
Synonym: adonitol
Synonym: ribitol
Tree Number: T6.2.2.9.8
Tree Number: T6.8.9.8
database_cross_reference: CHV:0000010876
database_cross_reference: LNC:LP61775-0
database_cross_reference: MSH:D012255
database_cross_reference: NDDF:004913
database_cross_reference: NDFRT:N0000168412
database_cross_reference: SNOMEDCT_US:116271007

Sorbitol
type: Class
subclass of: Sugar Alcohols
MCID: MC00012057
PMOID: PMO:00015776
Subclass_of: Sugar Alcohols
Synonym: (-)-sorbitol
Synonym: (−)-sorbitol
Synonym: Char-flo With Sorbitol - Sus
Synonym: Cystosol W 3% Hexitols
Synonym: D glucitol
Synonym: D-(-)-sorbitol
Synonym: D-(−)-sorbitol
Synonym: D-Glucitol
Synonym: D-Sorbit
Synonym: D-Sorbitol
Tree Number: T6.2.2.9.9
Tree Number: T6.8.9.9
database_cross_reference: AOD:0000019753
database_cross_reference: ATC:A06AD18
database_cross_reference: ATC:A06AG07
database_cross_reference: ATC:B05CX02
database_cross_reference: ATC:V04CC01
database_cross_reference: CHV:0000011533
database_cross_reference: CSP:2828-5010
database_cross_reference: DRUGBANK:DB01638
database_cross_reference: FMA:82796
database_cross_reference: LCH:U004391
database_cross_reference: LCH_NW:sh85125297
database_cross_reference: LNC:LP62208-1
database_cross_reference: MMSL:11078
database_cross_reference: MMSL:5502
database_cross_reference: MMSL:d04159
database_cross_reference: MSH:D013012
database_cross_reference: MTHSPL:506T60A25R
database_cross_reference: NCI:C29462
database_cross_reference: NCI_FDA:506T60A25R
database_cross_reference: NDDF:002599
database_cross_reference: NDFRT:N0000006662
database_cross_reference: NDFRT:N0000146220
database_cross_reference: RCD:X798Q
database_cross_reference: RXNORM:9945
database_cross_reference: SNM:F-11960
database_cross_reference: SNMI:C-848B0
database_cross_reference: SNMI:F-61A60
database_cross_reference: SNOMEDCT_US:19839007
database_cross_reference: SNOMEDCT_US:412513004
database_cross_reference: SNOMEDCT_US:89939002
database_cross_reference: VANDF:4017867

Isosorbide
type: Class
subclass of: Sorbitol
MCID: MC00007114
PMOID: PMO:00015777
Subclass_of: Sorbitol
Synonym: D-Glucitol, 1,4:3,6-dianhydro-
Synonym: ISOSORBIDE
Synonym: Isosorbide (product)
Synonym: Isosorbide (substance)
Synonym: Isosorbide [Chemical/Ingredient]
Synonym: isosorbide
Tree Number: T6.8.9.9.1
database_cross_reference: AOD:0000019754
database_cross_reference: CHV:0000006967
database_cross_reference: DRUGBANK:DB00883
database_cross_reference: DRUGBANK:DB01020
database_cross_reference: LNC:LP171613-5
database_cross_reference: MMSL:4933
database_cross_reference: MMSL:d00653
database_cross_reference: MSH:D007547
database_cross_reference: MTHSPL:WXR179L51S
database_cross_reference: NCI:C60773
database_cross_reference: NCI_FDA:WXR179L51S
database_cross_reference: NDDF:000687
database_cross_reference: NDFRT:N0000006345
database_cross_reference: NDFRT:N0000146900
database_cross_reference: RXNORM:6057
database_cross_reference: SNOMEDCT_US:108478001
database_cross_reference: SNOMEDCT_US:386853004
database_cross_reference: VANDF:4018584

Meglumine
type: Class
subclass of: Sorbitol
subclass of: PMO:00020902
MCID: MC00007985
PMOID: PMO:00015779
Subclass_of: Hexosamines
Subclass_of: Sorbitol
Synonym: 1-Deoxy-1-methylaminosorbitol
Synonym: D-(-)-N-Methylglucamine
Synonym: D-Glucitol, 1-deoxy-1-(methylamino)-
Synonym: MEGLUMINE
Synonym: Meglumine [Chemical/Ingredient]
Synonym: Methylglucamine
Synonym: N-Methyl-D(-)-glucamine
Synonym: meglumine
Synonym: methylglucamine
Tree Number: T6.8.2.1.3
Tree Number: T6.8.9.9.2
database_cross_reference: CHV:0000007886
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D008536
database_cross_reference: MTHSPL:6HG8UB2MUY
database_cross_reference: NCI:C61828
database_cross_reference: NCI_FDA:6HG8UB2MUY
database_cross_reference: NDDF:010198
database_cross_reference: NDFRT:N0000007289
database_cross_reference: NDFRT:N0000147678
database_cross_reference: RXNORM:6704
database_cross_reference: VANDF:4019579

Xylitol
type: Class
subclass of: Sugar Alcohols
MCID: MC00013772
PMOID: PMO:00015782
Subclass_of: Sugar Alcohols
Synonym: XYLITOL
Synonym: Xylitol (product)
Synonym: Xylitol (substance)
Synonym: Xylitol (substance) -RETIRED-
Synonym: Xylitol -RETIRED-
Synonym: Xylitol [Chemical/Ingredient]
Synonym: xylitol
Tree Number: T6.2.2.9.10
Tree Number: T6.8.9.10
database_cross_reference: AOD:0000019757
database_cross_reference: CHV:0000013242
database_cross_reference: DRUGBANK:DB01904
database_cross_reference: DRUGBANK:DB11195
database_cross_reference: LCH:U005066
database_cross_reference: LCH_NW:sh85148854
database_cross_reference: LNC:LP62192-7
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D014993
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: MTHSPL:VCQ006KQ1E
database_cross_reference: NCI:C76517
database_cross_reference: NCI_FDA:VCQ006KQ1E
database_cross_reference: NDDF:006331
database_cross_reference: NDFRT:N0000007463
database_cross_reference: NDFRT:N0000148228
database_cross_reference: RCD:Ub01H
database_cross_reference: RXNORM:11377
database_cross_reference: SNOMEDCT_US:116270008
database_cross_reference: SNOMEDCT_US:116540004
database_cross_reference: SNOMEDCT_US:395951005
database_cross_reference: SNOMEDCT_US:398986008
database_cross_reference: VANDF:4020499

Propanols
type: Class
subclass of: Alcohols
MCID: MC00066533
PMOID: PMO:00015783
Subclass_of: Alcohols
Synonym: 1-proponol
Synonym: Alcohols, Propyl
Synonym: Propanol
Synonym: Propanol (substance)
Synonym: Propanols [Chemical/Ingredient]
Synonym: Propyl Alcohols
Synonym: Propyl alcohol
Synonym: propanol
Synonym: propyl alcohol
Tree Number: T6.2.2.10
database_cross_reference: CHV:0000018215
database_cross_reference: CSP:0081-3220
database_cross_reference: DRUGBANK:DB03175
database_cross_reference: LCH:U005136
database_cross_reference: LCH_NW:sh85107481
database_cross_reference: MSH:D020005
database_cross_reference: MTH:U000003
database_cross_reference: NDFRT:N0000008112
database_cross_reference: RCD:X80CH
database_cross_reference: SNOMEDCT_US:259270005

1-Propanol
type: Class
subclass of: Propanols
MCID: MC00000518
PMOID: PMO:00015784
Subclass_of: Propanols
Synonym: 1 Propanol
Synonym: 1-Propanol [Chemical/Ingredient]
Synonym: 1-propanol
Synonym: 1-proponol
Synonym: Alcohol, Propyl
Synonym: N-propanol
Synonym: N-propyl alcohol
Synonym: PROPANOL 01
Synonym: PROPANOL N
Synonym: PROPYL ALCOHOL
Tree Number: T6.2.2.10.1
database_cross_reference: AOD:0000019701
database_cross_reference: AOD:0000028738
database_cross_reference: AOD:0000028739
database_cross_reference: ATC:D08AX03
database_cross_reference: CHV:0000000871
database_cross_reference: DRUGBANK:DB03175
database_cross_reference: LNC:LP19173-1
database_cross_reference: LNC:MTHU007487
database_cross_reference: MSH:D000433
database_cross_reference: MTH:U001672
database_cross_reference: MTHSPL:96F264O9SV
database_cross_reference: NDDF:007055
database_cross_reference: NDFRT:N0000166835
database_cross_reference: RCD:Xa7Np
database_cross_reference: RXNORM:1362872
database_cross_reference: SNM:E-5514
database_cross_reference: SNMI:C-21008
database_cross_reference: SNOMEDCT_US:299995007
database_cross_reference: SNOMEDCT_US:78843001

2-Propanol
type: Class
subclass of: Propanols
MCID: MC00007109
PMOID: PMO:00015785
Subclass_of: Propanols
Synonym: 2 Propanol
Synonym: 2-Propanol [Chemical/Ingredient]
Synonym: 25 Person ANSI
Synonym: 3M DuraPrep Surgical
Synonym: 3m Soluprep Sponge
Synonym: 50 Person ANSI
Synonym: 50 percent Isopropyl alcohol
Synonym: 50% Isopropyl Rubbing Alcohol
Synonym: 50% Isopropyl Rubbing Alcohol with Wintergreen
Synonym: 50% Rubbing
Tree Number: T6.2.2.10.3
database_cross_reference: AOD:0000000617
database_cross_reference: AOD:0000028743
database_cross_reference: AOD:0000028745
database_cross_reference: ATC:D08AX05
database_cross_reference: CHV:0000006963
database_cross_reference: DRUGBANK:DB00898
database_cross_reference: DRUGBANK:DB02325
database_cross_reference: LCH_NW:sh2003005845
database_cross_reference: LNC:LP14375-7
database_cross_reference: LNC:MTHU005007
database_cross_reference: MDDB:06195
database_cross_reference: MDDB:06201
database_cross_reference: MEDCIN:250109
database_cross_reference: MMSL:11314
database_cross_reference: MMSL:4930
database_cross_reference: MSH:D019840
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:ND2M416302
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C602
database_cross_reference: NCI_DTP:NSC0135801
database_cross_reference: NCI_FDA:ND2M416302
database_cross_reference: NDDF:002465
database_cross_reference: NDFRT:N0000005909
database_cross_reference: NDFRT:N0000145970
database_cross_reference: NDFRT:N0000146763
database_cross_reference: RCD:X80CE
database_cross_reference: RCD:XaCyH
database_cross_reference: RXNORM:797541
database_cross_reference: SNM:E-5513
database_cross_reference: SNMI:C-21007
database_cross_reference: SNOMEDCT_US:259215007
database_cross_reference: SNOMEDCT_US:259268001
database_cross_reference: SNOMEDCT_US:311549002
database_cross_reference: SNOMEDCT_US:414547000
database_cross_reference: SNOMEDCT_US:85062008
database_cross_reference: VANDF:4017589
database_cross_reference: VANDF:4018437

Aldehydes
type: Class
subclass of: Organic Chemicals
MCID: MC00000533
PMOID: PMO:00015786
Subclass_of: Organic Chemicals
Synonym: 214 ALDEHYDES
Synonym: ALDEHYDES
Synonym: Aldehyde
Synonym: Aldehyde (substance)
Synonym: Aldehyde, NOS
Synonym: Aldehydes [Chemical/Ingredient]
Synonym: aldehyde
Synonym: aldehydes
Tree Number: T6.2.3
database_cross_reference: AOD:0000018363
database_cross_reference: CHV:0000000880
database_cross_reference: CSP:0081-8501
database_cross_reference: LCH:U000136
database_cross_reference: LCH_NW:sh85003324
database_cross_reference: MSH:D000447
database_cross_reference: NCI:C94714
database_cross_reference: NCI_NCI-GLOSS:CDR0000463111
database_cross_reference: NDFRT:N0000008128
database_cross_reference: RCD:X794T
database_cross_reference: SNM:E-5620
database_cross_reference: SNM:U000137
database_cross_reference: SNMI:C-21400
database_cross_reference: SNOMEDCT_US:60530008

Acetaldehyde
type: Class
subclass of: Aldehydes
MCID: MC00000169
PMOID: PMO:00015787
Subclass_of: Aldehydes
Synonym: ACETALDEHYDE
Synonym: Acetaldehyde (substance)
Synonym: Acetaldehyde [Chemical/Ingredient]
Synonym: Acetic Aldehyde
Synonym: Acetylaldehyde
Synonym: Ethanal
Synonym: Ethyl Aldehyde
Synonym: Ethylaldehyde
Synonym: acetaldehyde
Synonym: acetic aldehyde
Tree Number: T6.2.3.1
database_cross_reference: AOD:0000001857
database_cross_reference: AOD:0000028778
database_cross_reference: CHV:0000000598
database_cross_reference: CSP:0081-8970
database_cross_reference: LNC:LP15311-1
database_cross_reference: LNC:MTHU007073
database_cross_reference: MSH:D000079
database_cross_reference: MTHSPL:GO1N1ZPR3B
database_cross_reference: NCI:C44328
database_cross_reference: NCI_FDA:GO1N1ZPR3B
database_cross_reference: NDFRT:N0000008110
database_cross_reference: PSY:00415
database_cross_reference: PSY:00425
database_cross_reference: PSY:18038
database_cross_reference: PSY:18184
database_cross_reference: RCD:X794Q
database_cross_reference: RXNORM:1311137
database_cross_reference: SNM:E-5624
database_cross_reference: SNMI:C-21404
database_cross_reference: SNOMEDCT_US:38705000

Paraldehyde
type: Class
subclass of: Acetaldehyde
MCID: MC00009705
PMOID: PMO:00015788
Subclass_of: Acetaldehyde
Synonym: 1,3,5-Trioxane, 2,4,6-trimethyl-
Synonym: PARALDEHYDE
Synonym: Paracetaldehyde
Synonym: Paraldehyde (product)
Synonym: Paraldehyde (substance)
Synonym: Paraldehyde Inj Bp 100%
Synonym: Paraldehyde Injection BP
Synonym: Paraldehyde [Chemical/Ingredient]
Synonym: Paraldehyde product
Synonym: paracetaldehyde
Tree Number: T6.2.3.1.1
database_cross_reference: AOD:0000019796
database_cross_reference: AOD:0000028779
database_cross_reference: ATC:N05CC05
database_cross_reference: CHV:0000009268
database_cross_reference: DRUGBANK:DB09117
database_cross_reference: LNC:LP16235-1
database_cross_reference: LNC:MTHU008129
database_cross_reference: MEDCIN:41182
database_cross_reference: MMSL:42494
database_cross_reference: MMSL:5232
database_cross_reference: MMSL:d00911
database_cross_reference: MSH:D010242
database_cross_reference: MTH:U002141
database_cross_reference: NDDF:001429
database_cross_reference: NDFRT:N0000007474
database_cross_reference: NDFRT:N0000146529
database_cross_reference: PSY:36305
database_cross_reference: RCD:X80C1
database_cross_reference: RCD:do5..
database_cross_reference: RXNORM:7909
database_cross_reference: SNM:E-7883
database_cross_reference: SNMI:C-64304
database_cross_reference: SNOMEDCT_US:259257001
database_cross_reference: SNOMEDCT_US:35324004
database_cross_reference: SNOMEDCT_US:387190006
database_cross_reference: VANDF:4018195

Acrolein
type: Class
subclass of: Aldehydes
MCID: MC00000273
PMOID: PMO:00015789
Subclass_of: Aldehydes
Synonym: 2 Propenal
Synonym: 2-Propenal
Synonym: Acraldehyde
Synonym: Acrolein (substance)
Synonym: Acrolein [Chemical/Ingredient]
Synonym: Acrylaldehyde
Synonym: Acrylic Aldehyde
Synonym: Acrylic aldehyde
Synonym: Aldehyde, Acrylic
Synonym: Aldehyde, Allyl
Tree Number: T6.2.3.2
database_cross_reference: CSP:0094-2700
database_cross_reference: LCH_NW:sh00009449
database_cross_reference: LNC:LP19575-7
database_cross_reference: LNC:MTHU009448
database_cross_reference: MSH:D000171
database_cross_reference: NDFRT:N0000166840
database_cross_reference: RCD:X794R
database_cross_reference: SNM:E-5628
database_cross_reference: SNMI:C-21408
database_cross_reference: SNOMEDCT_US:85937005

Benzaldehydes
type: Class
subclass of: Aldehydes
MCID: MC00001559
PMOID: PMO:00015790
Subclass_of: Aldehydes
Synonym: Benzaldehydes [Chemical/Ingredient]
Tree Number: T6.2.3.3
database_cross_reference: MSH:D001547
database_cross_reference: NDFRT:N0000007519

Formaldehyde
type: Class
subclass of: Aldehydes
MCID: MC00005263
PMOID: PMO:00015791
Subclass_of: Aldehydes
Synonym: British Army Foot Pwr
Synonym: FORMALDEHYDE
Synonym: Formaldehyde (substance)
Synonym: Formaldehyde [Chemical/Ingredient]
Synonym: Formaldehyde product
Synonym: Formaldehyde product (product)
Synonym: Formaldehyde product (substance)
Synonym: Formic Aldehyde
Synonym: Methanal
Synonym: Methyl Aldehyde
Tree Number: T6.2.3.4
database_cross_reference: AOD:0000019794
database_cross_reference: AOD:0000028777
database_cross_reference: CHV:0000005217
database_cross_reference: CSP:0081-9437
database_cross_reference: DRUGBANK:DB03843
database_cross_reference: LCH:U001859
database_cross_reference: LCH_NW:sh85050805
database_cross_reference: LNC:LA15929-5
database_cross_reference: LNC:LP16819-2
database_cross_reference: LNC:MTHU004682
database_cross_reference: MEDCIN:48410
database_cross_reference: MMSL:286
database_cross_reference: MMSL:4763
database_cross_reference: MSH:D005557
database_cross_reference: MTH:U001933
database_cross_reference: MTHSPL:1HG84L3525
database_cross_reference: NCI:C29744
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_FDA:1HG84L3525
database_cross_reference: NCI_NCI-GLOSS:CDR0000269439
database_cross_reference: NDDF:003204
database_cross_reference: NDFRT:N0000006222
database_cross_reference: NDFRT:N0000147328
database_cross_reference: RCD:XM0lQ
database_cross_reference: RCD:m83..
database_cross_reference: RXNORM:4530
database_cross_reference: SNM:E-5621
database_cross_reference: SNMI:C-21402
database_cross_reference: SNOMEDCT_US:111095003
database_cross_reference: SNOMEDCT_US:332436004
database_cross_reference: VANDF:4019061

Formocresols
type: Class
subclass of: Formaldehyde
MCID: MC00005274
PMOID: PMO:00015792
Subclass_of: Formaldehyde
Synonym: Formocresols [Chemical/Ingredient]
Tree Number: T6.2.3.4.1
database_cross_reference: MSH:D005566
database_cross_reference: NDFRT:N0000166841

Furaldehyde
type: Class
subclass of: Aldehydes
subclass of: Furans
MCID: MC00005352
PMOID: PMO:00015793
Subclass_of: Aldehydes
Subclass_of: Furans
Synonym: 2-Furancarboxaldehyde
Synonym: Furaldehyde [Chemical/Ingredient]
Synonym: Furfural
Synonym: furfural
Tree Number: T6.2.3.5
Tree Number: T6.3.5.10.3
database_cross_reference: CHV:0000005295
database_cross_reference: LCH_NW:sh99011536
database_cross_reference: MSH:D005662
database_cross_reference: NDFRT:N0000167139

Glutaral
type: Class
subclass of: Aldehydes
MCID: MC00005702
PMOID: PMO:00015794
Subclass_of: Aldehydes
Synonym: GLUTARAL
Synonym: GLUTARALDEHYDE
Synonym: Glutaral [Chemical/Ingredient]
Synonym: Glutaraldehyde
Synonym: Glutaraldehyde (product)
Synonym: Glutaraldehyde (substance)
Synonym: Glutaraldehyde product
Synonym: Glutaraldehyde product (product)
Synonym: Glutaraldehyde product (substance)
Synonym: Glutardialdehyde
Tree Number: T6.2.3.6
database_cross_reference: AOD:0000019801
database_cross_reference: CHV:0000005589
database_cross_reference: CSP:4001-0061
database_cross_reference: DRUGBANK:DB03266
database_cross_reference: LCH_NW:sh2010014517
database_cross_reference: LNC:LP14378-1
database_cross_reference: LNC:MTHU011544
database_cross_reference: MEDCIN:48610
database_cross_reference: MSH:D005976
database_cross_reference: MTHSPL:T3C89M417N
database_cross_reference: NCI:C80930
database_cross_reference: NCI_FDA:T3C89M417N
database_cross_reference: NDDF:003180
database_cross_reference: NDFRT:N0000006501
database_cross_reference: NDFRT:N0000148249
database_cross_reference: RCD:XM0lR
database_cross_reference: RCD:m84..
database_cross_reference: RXNORM:4888
database_cross_reference: SNM:E-5633
database_cross_reference: SNMI:C-21412
database_cross_reference: SNOMEDCT_US:22242006
database_cross_reference: SNOMEDCT_US:255865001
database_cross_reference: SNOMEDCT_US:332445003
database_cross_reference: SNOMEDCT_US:411200007
database_cross_reference: VANDF:4020533

Glyceraldehyde
type: Class
subclass of: Aldehydes
MCID: MC00005719
PMOID: PMO:00015795
Subclass_of: Aldehydes
Synonym: 2,3-dihydroxypropanal
Synonym: Glyceraldehyde (substance)
Synonym: Glyceraldehyde [Chemical/Ingredient]
Synonym: Propanal, 2,3-dihydroxy-
Synonym: glyceraldehyde
Synonym: glyceric aldehyde
Tree Number: T6.2.3.7
database_cross_reference: AOD:0000019797
database_cross_reference: AOD:0000028780
database_cross_reference: AOD:0000028784
database_cross_reference: CSP:2998-1200
database_cross_reference: MSH:D005985
database_cross_reference: NDFRT:N0000168493
database_cross_reference: SNM:F-11100
database_cross_reference: SNMI:F-61100
database_cross_reference: SNOMEDCT_US:54045000

Glyceraldehyde 3-Phosphate
type: Class
subclass of: Glyceraldehyde
MCID: MC00005720
PMOID: PMO:00015796
Subclass_of: Glyceraldehyde
Synonym: 3 Phosphoglyceraldehyde
Synonym: 3-Phosphoglyceraldehyde
Synonym: GLYCERALDEHYDEPHOSPHATE A 03
Synonym: Glyceraldehyde 3 Phosphate
Synonym: Glyceraldehyde 3-Phosphate [Chemical/Ingredient]
Synonym: Glyceraldehyde-3-Phosphate
Synonym: Glyceraldehyde-3-phosphate
Synonym: Glyceraldehyde-3-phosphate (substance)
Synonym: PHOSPHOGLYCERALDEHYDE A 03
Synonym: Propanal, 2-hydroxy-3-(phosphonooxy)-
Tree Number: T6.2.3.7.1
database_cross_reference: AOD:0000019799
database_cross_reference: CHV:0000005597
database_cross_reference: CSP:0551-7347
database_cross_reference: DRUGBANK:DB02263
database_cross_reference: MSH:D005986
database_cross_reference: NDFRT:N0000168494
database_cross_reference: SNM:F-11100
database_cross_reference: SNMI:F-61108
database_cross_reference: SNOMEDCT_US:47167003

Glyoxal
type: Class
subclass of: Aldehydes
MCID: MC00005778
PMOID: PMO:00015797
Subclass_of: Aldehydes
Synonym: Ethanedial
Synonym: Ethanedione
Synonym: GLYOXAL
Synonym: Glyoxal [Chemical/Ingredient]
Synonym: glyoxal
Tree Number: T6.2.3.8
database_cross_reference: CHV:0000005633
database_cross_reference: CSP:1673-4619
database_cross_reference: LCH_NW:sh2005003558
database_cross_reference: MSH:D006037
database_cross_reference: MTHSPL:50NP6JJ975
database_cross_reference: NDDF:006889
database_cross_reference: NDFRT:N0000166837
database_cross_reference: RXNORM:4967

Phenylglyoxal
type: Class
subclass of: Glyoxal
MCID: MC00010047
PMOID: PMO:00015798
Subclass_of: Glyoxal
Synonym: Benzeneacetaldehyde, alpha-oxo-
Synonym: Phenylglyoxal [Chemical/Ingredient]
Tree Number: T6.2.3.8.1
database_cross_reference: MSH:D010658
database_cross_reference: NDFRT:N0000166839

Pyruvaldehyde
type: Class
subclass of: Glyoxal
MCID: MC00011038
PMOID: PMO:00015799
Subclass_of: Glyoxal
Synonym: 2-ketopropionaldehyde
Synonym: 2-oxopropanal
Synonym: Acetyl formaldehyde
Synonym: Acetylformaldehyde
Synonym: Acetylformyl
Synonym: Aldehyde, Pyruvic
Synonym: Methyl glyoxal
Synonym: Methylglyoxal
Synonym: PYRUVALDEHYDE
Synonym: Propanal, 2-oxo-
Tree Number: T6.2.3.8.2
database_cross_reference: DRUGBANK:DB03587
database_cross_reference: MSH:D011765
database_cross_reference: MTHSPL:722KLD7415
database_cross_reference: NDFRT:N0000166838
database_cross_reference: RXNORM:1373350

Malondialdehyde
type: Class
subclass of: Aldehydes
MCID: MC00007869
PMOID: PMO:00015800
Subclass_of: Aldehydes
Synonym: 1,3-Propanedial
Synonym: 1,3-Propanedialdehyde
Synonym: 1,3-Propanedione
Synonym: MALONDIALDEHYDE
Synonym: Malonaldehyde
Synonym: Malonaldehyde (substance)
Synonym: Malondialdehyde [Chemical/Ingredient]
Synonym: Malonic Aldehyde
Synonym: Malonicdialdehyde
Synonym: Malonodialdehyde
Tree Number: T6.2.3.9
database_cross_reference: AOD:0000019804
database_cross_reference: AOD:0000028788
database_cross_reference: AOD:0000028789
database_cross_reference: CHV:0000007704
database_cross_reference: CSP:0881-0662
database_cross_reference: DRUGBANK:DB03057
database_cross_reference: LCH_NW:sh00007059
database_cross_reference: LNC:LP61822-0
database_cross_reference: LNC:MTHU025311
database_cross_reference: MSH:D008315
database_cross_reference: MTHSPL:4Y8F71G49Q
database_cross_reference: NCI:C94711
database_cross_reference: NCI_FDA:4Y8F71G49Q
database_cross_reference: NCI_NCI-GLOSS:CDR0000373088
database_cross_reference: NDFRT:N0000166843
database_cross_reference: RXNORM:1657018
database_cross_reference: SNOMEDCT_US:706962006

Thiobarbituric Acid Reactive Substances
type: Class
subclass of: Malondialdehyde
MCID: MC00063403
PMOID: PMO:00015801
Subclass_of: Malondialdehyde
Synonym: TBARs
Synonym: Thiobarbituric Acid Reactive Substances [Chemical/Ingredient]
Synonym: tbars
Tree Number: T6.2.3.9.1
database_cross_reference: CHV:0000017980
database_cross_reference: MSH:D017392
database_cross_reference: NDFRT:N0000166844

o-Phthalaldehyde
type: Class
subclass of: Aldehydes
MCID: MC00009084
PMOID: PMO:00015802
Subclass_of: Aldehydes
Synonym: 1,2-Benzenedicarboxaldehyde
Synonym: Aldehyde, ortho-Phthalic
Synonym: ORTHOPHTHALALDEHYDE
Synonym: Orthophthaldialdehyde
Synonym: PHTHALALDEHYDE O
Synonym: o Phthalaldehyde
Synonym: o Phthaldialdehyde
Synonym: o-Phthalaldehyde [Chemical/Ingredient]
Synonym: o-Phthaldialdehyde
Synonym: o-phthalaldehyde
Tree Number: T6.2.3.10
database_cross_reference: CHV:0000008859
database_cross_reference: MSH:D009764
database_cross_reference: NDDF:009893
database_cross_reference: NDFRT:N0000148683
database_cross_reference: NDFRT:N0000166842
database_cross_reference: RXNORM:7602
database_cross_reference: VANDF:4021241

Retinaldehyde
type: Class
subclass of: Aldehydes
MCID: MC00011320
PMOID: PMO:00015803
Subclass_of: Aldehydes
Synonym: Aldehyde, Vitamin A
Synonym: Axerophthal
Synonym: RETINAL, ALL-TRANS
Synonym: Retinal
Synonym: Retinaldehyde (substance)
Synonym: Retinaldehyde [Chemical/Ingredient]
Synonym: Retinene
Synonym: Retinyl Aldehyde
Synonym: Vitamin A Aldehyde
Synonym: retinal
Tree Number: T6.2.3.11
database_cross_reference: AOD:0000020993
database_cross_reference: CHV:0000010810
database_cross_reference: CSP:2328-3889
database_cross_reference: CSP:3147-4026
database_cross_reference: LNC:LP15851-6
database_cross_reference: MSH:D012172
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C68300
database_cross_reference: NCI_CRCH:C68300
database_cross_reference: NCI_FDA:RR725D715M
database_cross_reference: NDDF:016731
database_cross_reference: NDFRT:N0000171228
database_cross_reference: SNMI:F-BB055
database_cross_reference: SNOMEDCT_US:103067001

Amides
type: Class
subclass of: Organic Chemicals
MCID: MC00000715
PMOID: PMO:00015804
Subclass_of: Organic Chemicals
Synonym: 218 AMIDES
Synonym: AMIDES
Synonym: Amide
Synonym: Amide (substance)
Synonym: Amide, NOS
Synonym: Amides [Chemical/Ingredient]
Synonym: amide
Synonym: amides
Tree Number: T6.2.4
database_cross_reference: AOD:0000020168
database_cross_reference: CHV:0000001000
database_cross_reference: CSP:0113-1292
database_cross_reference: LCH:U000187
database_cross_reference: LCH_NW:sh85004464
database_cross_reference: MSH:D000577
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007681
database_cross_reference: SNM:E-5720
database_cross_reference: SNM:U000140
database_cross_reference: SNMI:C-21800
database_cross_reference: SNOMEDCT_US:31414002

Bimatoprost
type: Class
subclass of: Amides
MCID: MC00335187
PMOID: PMO:00015805
Subclass_of: Amides
Synonym: (Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1e,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide
Synonym: 5-Heptenamide, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-,(5Z)-
Synonym: 5-Heptenamide, 7-(3,5-dihydroxy-2-(3-hydrdoxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (1R-(1alpha(Z),2beta(1E,3S*),3alpha,5alpha))-
Synonym: Apo-bimatoprost
Synonym: BIMATOPROST
Synonym: Bimatoprost (product)
Synonym: Bimatoprost (substance)
Synonym: Bimatoprost [Chemical/Ingredient]
Synonym: Bimatoprostum
Synonym: Lumigan PF
Tree Number: T6.2.4.1
database_cross_reference: ATC:S01EE03
database_cross_reference: CHV:0000052892
database_cross_reference: DRUGBANK:DB00905
database_cross_reference: MEDCIN:195475
database_cross_reference: MMSL:15937
database_cross_reference: MMSL:234008
database_cross_reference: MSH:D000069580
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:QXS94885MZ
database_cross_reference: NCI:C47414
database_cross_reference: NCI_FDA:QXS94885MZ
database_cross_reference: NCI_NCI-GLOSS:CDR0000666204
database_cross_reference: NDDF:009115
database_cross_reference: NDFRT:N0000010075
database_cross_reference: NDFRT:N0000148703
database_cross_reference: RXNORM:283810
database_cross_reference: SNOMEDCT_US:129492005
database_cross_reference: SNOMEDCT_US:395300006
database_cross_reference: USPMG:MTHU001586
database_cross_reference: VANDF:4021262

Acetamides
type: Class
subclass of: Amides
MCID: MC00000171
PMOID: PMO:00015806
Subclass_of: Amides
Synonym: Acetamides [Chemical/Ingredient]
Tree Number: T6.2.4.2
database_cross_reference: MSH:D000081
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008113

Linezolid
type: Class
subclass of: Acetamides
MCID: MC00217917
PMOID: PMO:00015807
Subclass_of: Acetamides
Synonym: Antizolid
Synonym: Apo-linezolid
Synonym: Gpc-linezolid Injection
Synonym: LINEZOLID
Synonym: Linezolid (product)
Synonym: Linezolid (substance)
Synonym: Linezolid [Chemical/Ingredient]
Synonym: Linezolide
Synonym: Linezolidum
Synonym: Linosept
Tree Number: T6.2.4.2.1
database_cross_reference: ATC:J01XX08
database_cross_reference: CHV:0000042522
database_cross_reference: DRUGBANK:DB00601
database_cross_reference: LNC:LP21256-0
database_cross_reference: LNC:MTHU013614
database_cross_reference: MEDCIN:192413
database_cross_reference: MMSL:229070
database_cross_reference: MMSL:8840
database_cross_reference: MMSL:d04534
database_cross_reference: MSH:D000069349
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:ISQ9I6J12J
database_cross_reference: NCI:C29158
database_cross_reference: NCI_FDA:ISQ9I6J12J
database_cross_reference: NDDF:008223
database_cross_reference: NDFRT:N0000006027
database_cross_reference: NDFRT:N0000148664
database_cross_reference: RXNORM:190376
database_cross_reference: SNOMEDCT_US:125695009
database_cross_reference: SNOMEDCT_US:387056004
database_cross_reference: USPMG:MTHU000232
database_cross_reference: VANDF:4021218

Allylisopropylacetamide
type: Class
subclass of: Acetamides
MCID: MC00000596
PMOID: PMO:00015808
Subclass_of: Acetamides
Synonym: 2 Isopropyl 4 Pentenamide
Synonym: 2-(1-Methylethyl)-4-pentenamide
Synonym: 2-Isopropyl-4-Pentenamide
Synonym: 4-Pentenamide, 2-(1-methylethyl)-
Synonym: AI3-61022
Synonym: Allylisopropylacetamide [Chemical/Ingredient]
Synonym: Ro 01-0973
Tree Number: T6.2.4.2.2
database_cross_reference: MSH:D000502
database_cross_reference: NCI:C64186
database_cross_reference: NCI_DCP:30238
database_cross_reference: NDFRT:N0000166890

Iodoacetamide
type: Class
subclass of: Acetamides
MCID: MC00006997
PMOID: PMO:00015809
Subclass_of: Acetamides
Synonym: Acetamide, 2-iodo-
Synonym: Iodoacetamide [Chemical/Ingredient]
Tree Number: T6.2.4.2.3
database_cross_reference: MSH:D007460
database_cross_reference: NDFRT:N0000166891

Piracetam
type: Class
subclass of: Acetamides
MCID: MC00010244
PMOID: PMO:00015810
Subclass_of: Acetamides
Synonym: 1-Pyrrolidineacetamide, 2-oxo-
Synonym: 2-Pyrrolidone-N-Acetamide
Synonym: Myocalm
Synonym: PIRACETAM
Synonym: Piracetam (product)
Synonym: Piracetam (substance)
Synonym: Piracetam [Chemical/Ingredient]
Synonym: Pirazetam
Synonym: Pyracetam
Synonym: Pyramem
Tree Number: T6.2.4.2.4
database_cross_reference: AOD:0000020170
database_cross_reference: ATC:N06BX03
database_cross_reference: CHV:0000009751
database_cross_reference: DRUGBANK:DB09210
database_cross_reference: MEDCIN:305549
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D010889
database_cross_reference: MTHSPL:ZH516LNZ10
database_cross_reference: NCI:C66410
database_cross_reference: NCI_FDA:ZH516LNZ10
database_cross_reference: NDDF:004363
database_cross_reference: NDFRT:N0000007934
database_cross_reference: PSY:38900
database_cross_reference: RCD:dng..
database_cross_reference: RXNORM:8351
database_cross_reference: SNOMEDCT_US:322998004
database_cross_reference: SNOMEDCT_US:395833008

Thioacetamide
type: Class
subclass of: Acetamides
subclass of: Thioamides
MCID: MC00012724
PMOID: PMO:00015811
Subclass_of: Acetamides
Subclass_of: Thioamides
Synonym: Acetothioamide
Synonym: Ethanethioamide
Synonym: Sulfo-amine
Synonym: TAA
Synonym: THIOACETAMIDE
Synonym: Thiacetamid
Synonym: Thioacetamid
Synonym: Thioacetamide [Chemical/Ingredient]
Synonym: Thioacetimidic Acid
Synonym: thioacetamid
Tree Number: T6.2.32.15.1
Tree Number: T6.2.4.14.1
Tree Number: T6.2.4.2.5
database_cross_reference: AOD:0000020171
database_cross_reference: CHV:0000012184
database_cross_reference: CSP:2903-5246
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D013853
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44454
database_cross_reference: NCI_FDA:075T165X8M
database_cross_reference: NDFRT:N0000166892

2-Acetylaminofluorene
type: Class
subclass of: Acetamides
subclass of: Fluorenes
MCID: MC00000034
PMOID: PMO:00015812
Subclass_of: Acetamides
Subclass_of: Fluorenes
Synonym: 2 Acetamidofluorene
Synonym: 2 Acetylaminofluorene
Synonym: 2 Fluorenylacetamide
Synonym: 2-AAF
Synonym: 2-ACETYLAMINOFLUORENE
Synonym: 2-Acetamidofluorene
Synonym: 2-Acetylaminofluorene [Chemical/Ingredient]
Synonym: 2-FAA
Synonym: 2-Fluorenylacetamide
Synonym: AAF, Aminofluorene
Tree Number: T6.2.4.2.6
Tree Number: T6.4.3.4.2
database_cross_reference: LNC:LP34752-3
database_cross_reference: LNC:MTHU027462
database_cross_reference: MSH:D015073
database_cross_reference: NCI:C29791
database_cross_reference: NCI_FDA:9M98QLJ2DL
database_cross_reference: NDFRT:N0000167342

Benzeneacetamides
type: Class
subclass of: Acetamides
MCID: MC00421618
PMOID: PMO:00015815
Subclass_of: Acetamides
Synonym: 2-Phenylacetamides
Synonym: Benzeneacetamides [Chemical/Ingredient]
Tree Number: T6.2.4.2.7
database_cross_reference: MSH:D044482
database_cross_reference: NDFRT:N0000011341

Oseltamivir
type: Class
subclass of: Acetamides
MCID: MC00305394
PMOID: PMO:00015817
Subclass_of: Acetamides
Synonym: (-)-oseltamivir
Synonym: (−)-oseltamivir
Synonym: 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R-(3alpha,4beta,5alpha))-
Synonym: Agucort
Synonym: Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
Synonym: Nat-oseltamivir
Synonym: OSELTAMIVIR
Synonym: Oseltamivir (product)
Synonym: Oseltamivir (substance)
Synonym: Oseltamivir [Chemical/Ingredient]
Tree Number: T6.2.4.2.8
database_cross_reference: ATC:J05AH02
database_cross_reference: CHV:0000051664
database_cross_reference: DRUGBANK:DB00198
database_cross_reference: LNC:LP101308-7
database_cross_reference: LNC:MTHU036068
database_cross_reference: MMSL:d04462
database_cross_reference: MSH:D053139
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:20O93L6F9H
database_cross_reference: NCI:C62061
database_cross_reference: NCI_FDA:20O93L6F9H
database_cross_reference: NDDF:007918
database_cross_reference: NDFRT:N0000148635
database_cross_reference: NDFRT:N0000175097
database_cross_reference: RXNORM:260101
database_cross_reference: SNOMEDCT_US:386142008
database_cross_reference: SNOMEDCT_US:412261005
database_cross_reference: USPMG:MTHU000687
database_cross_reference: VANDF:4021189

Acrylamides
type: Class
subclass of: Amides
MCID: MC00000280
PMOID: PMO:00015818
Subclass_of: Amides
Synonym: Acrylamides [Chemical/Ingredient]
Synonym: acrylamides
Tree Number: T6.2.4.3
database_cross_reference: CHV:0000000661
database_cross_reference: MSH:D000178
database_cross_reference: NDFRT:N0000011219

Acrylamide
type: Class
subclass of: Acrylamides
MCID: MC00019158
PMOID: PMO:00015819
Subclass_of: Acrylamides
Synonym: 2-Propenamide
Synonym: ACRYLAMIDE
Synonym: Acrylamide (substance)
Synonym: Acrylamide [Chemical/Ingredient]
Synonym: Ethylene Carboxamide
Synonym: Propenoic Acid Amide
Synonym: Vinyl Amide
Synonym: acrylamide
Tree Number: T6.2.4.3.1
database_cross_reference: CHV:0000013427
database_cross_reference: CSP:0113-1826
database_cross_reference: LCH:U000045
database_cross_reference: LCH_NW:sh87000368
database_cross_reference: LNC:LP18223-5
database_cross_reference: LNC:MTHU002906
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D020106
database_cross_reference: MTHSPL:20R035KLCI
database_cross_reference: NCI:C44329
database_cross_reference: NCI_FDA:20R035KLCI
database_cross_reference: NDDF:014021
database_cross_reference: NDFRT:N0000166858
database_cross_reference: RCD:Xa0XC
database_cross_reference: RXNORM:1368125
database_cross_reference: SNMI:C-2A112
database_cross_reference: SNOMEDCT_US:6983000

Anilides
type: Class
subclass of: Amides
subclass of: Aniline Compounds
MCID: MC00000939
PMOID: PMO:00015820
Subclass_of: Amides
Subclass_of: Aniline Compounds
Synonym: Anilides [Chemical/Ingredient]
Synonym: anilide
Tree Number: T6.2.4.4
Tree Number: T6.2.6.5.2
database_cross_reference: AOD:0000020173
database_cross_reference: CSP:2268-7470
database_cross_reference: LCH_NW:sh91005148
database_cross_reference: MSH:D000813
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007515

Acetanilides
type: Class
subclass of: Anilides
MCID: MC00000174
PMOID: PMO:00015821
Subclass_of: Anilides
Synonym: Acetanilides [Chemical/Ingredient]
Synonym: Acetylanilines
Synonym: N-Phenylacetamides
Tree Number: T6.2.4.4.1
database_cross_reference: MSH:D000083
database_cross_reference: NDFRT:N0000007361

Ranolazine
type: Class
subclass of: Piperazines
MCID: MC00037072
PMOID: PMO:00015822
Subclass_of: Piperazines
Synonym: 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-(2-hydroxy- 3-(2-methoxyphenoxy)propyl)-
Synonym: N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide
Synonym: RANOLAZINE
Synonym: Ranolazine (product)
Synonym: Ranolazine (substance)
Synonym: Ranolazine [Chemical/Ingredient]
Synonym: Renolazine
Synonym: ranolazine
Synonym: ranolazine (medication)
Tree Number: T6.3.5.15.6
database_cross_reference: ATC:C01EB18
database_cross_reference: DRUGBANK:DB00243
database_cross_reference: MEDCIN:302336
database_cross_reference: MMSL:20936
database_cross_reference: MMSL:d05719
database_cross_reference: MSH:D000069458
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:A6IEZ5M406
database_cross_reference: NCI:C66507
database_cross_reference: NCI_FDA:A6IEZ5M406
database_cross_reference: NDDF:011195
database_cross_reference: NDFRT:N0000171743
database_cross_reference: NDFRT:N0000175343
database_cross_reference: RXNORM:35829
database_cross_reference: SNOMEDCT_US:420365007
database_cross_reference: SNOMEDCT_US:420624001
database_cross_reference: USPMG:MTHU002996
database_cross_reference: VANDF:4025078

Benzoylarginine Nitroanilide
type: Class
subclass of: Anilides
MCID: MC00001600
PMOID: PMO:00015830
Subclass_of: Anilides
Synonym: BAPA
Synonym: BAPNA
Synonym: Benzamide, N-(4-((aminoiminomethyl)amino)-1-(((4-nitrophenyl)amino)carbonyl)butyl)-, (+-)-
Synonym: Benzoylarginine Nitroanilide [Chemical/Ingredient]
Synonym: N Benzoylarginine 4 nitroanilide
Synonym: N Benzoylarginyl 4 nitroanilide
Synonym: N-Benzoylarginine-4-nitroanilide
Synonym: N-Benzoylarginyl-4-nitroanilide
Synonym: Nitroanilide, Benzoylarginine
Tree Number: T6.2.4.4.2
database_cross_reference: MSH:D001586
database_cross_reference: NDFRT:N0000170233

Bupivacaine
type: Class
subclass of: Anilides
MCID: MC00002022
PMOID: PMO:00015831
Subclass_of: Anilides
Synonym: (RS)-bupivacaine
Synonym: (Â±)-bupivacaine
Synonym: 1-Butyl-2',6'-pipecoloxylidide
Synonym: 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
Synonym: 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-
Synonym: BUPIVACAINE
Synonym: Bupivacaina
Synonym: Bupivacaine (product)
Synonym: Bupivacaine (substance)
Synonym: Bupivacaine HCl 0.5% and Epinephrine 1:200,000 Injection
Tree Number: T6.2.4.4.3
database_cross_reference: ATC:N01BB01
database_cross_reference: CHV:0000002225
database_cross_reference: DRUGBANK:DB00297
database_cross_reference: LNC:LP16053-8
database_cross_reference: LNC:MTHU014869
database_cross_reference: MEDCIN:309431
database_cross_reference: MMSL:d00180
database_cross_reference: MSH:D002045
database_cross_reference: MTHSPL:Y8335394RO
database_cross_reference: NCI:C62011
database_cross_reference: NCI_FDA:Y8335394RO
database_cross_reference: NCI_NCI-GLOSS:CDR0000597094
database_cross_reference: NDDF:005054
database_cross_reference: NDFRT:N0000007415
database_cross_reference: NDFRT:N0000147736
database_cross_reference: PDQ:CDR0000481366
database_cross_reference: RCD:x01AB
database_cross_reference: RXNORM:1815
database_cross_reference: SNMI:C-6B010
database_cross_reference: SNOMEDCT_US:27196008
database_cross_reference: SNOMEDCT_US:387150008
database_cross_reference: VANDF:4019643

Carbanilides
type: Class
subclass of: Anilides
subclass of: Phenylurea Compounds
MCID: MC00002210
PMOID: PMO:00015832
Subclass_of: Anilides
Subclass_of: Phenylurea Compounds
Synonym: Carbanilides [Chemical/Ingredient]
Synonym: Compounds, Diphenylurea
Synonym: DIPHENYLUREA CPDS
Synonym: Diphenylurea Compounds
Tree Number: T6.2.34.8.1
Tree Number: T6.2.4.4.4
database_cross_reference: MSH:D002224
database_cross_reference: NDFRT:N0000166895

Nicarbazin
type: Class
subclass of: Pyrimidines
MCID: MC00008873
PMOID: PMO:00015834
Subclass_of: Pyrimidines
Synonym: NICARBAZIN
Synonym: Nicarbazin (substance)
Synonym: Nicarbazin [Chemical/Ingredient]
Synonym: Nicarbazine
Synonym: Urea, N,N'-bis(4-nitrophenyl)-, compd. with 4,6-dimethyl-2(1H)-pyrimidinone (1:1)
Synonym: nicarbazin
Synonym: nicarbazine
Tree Number: T6.3.5.21.13
database_cross_reference: CHV:0000008701
database_cross_reference: MSH:D009528
database_cross_reference: MTHSPL:11P9NUA12U
database_cross_reference: NCI:C76086
database_cross_reference: NCI_FDA:11P9NUA12U
database_cross_reference: NDFRT:N0000167194
database_cross_reference: RXNORM:1311583
database_cross_reference: SNMI:C-56D50
database_cross_reference: SNOMEDCT_US:96165004

Carboxin
type: Class
subclass of: Anilides
subclass of: Oxathiins
MCID: MC00002254
PMOID: PMO:00015835
Subclass_of: Anilides
Subclass_of: Oxathiins
Synonym: 1,4-Oxathiin-3-carboxamide, 5,6-dihydro-2-methyl-N-phenyl-
Synonym: 5,6-Dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide
Synonym: Carboxin [Chemical/Ingredient]
Synonym: carboxin
Tree Number: T6.2.4.4.5
Tree Number: T6.3.5.12.1
database_cross_reference: CHV:0000002405
database_cross_reference: DRUGBANK:DB04657
database_cross_reference: MSH:D002261
database_cross_reference: NDFRT:N0000167117

Flutamide
type: Class
subclass of: Anilides
MCID: MC00005222
PMOID: PMO:00015836
Subclass_of: Anilides
Synonym: 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Synonym: 4'-Nitro-3'-trifluoromethylisobutyranilide
Synonym: Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide
Synonym: Andraxan
Synonym: Antipros
Synonym: Curestat
Synonym: Dedile
Synonym: Dom-flutamide
Synonym: Elbat
Synonym: Etaconil
Tree Number: T6.2.4.4.6
database_cross_reference: ATC:L02BB01
database_cross_reference: CHV:0000005138
database_cross_reference: CSP:0170-7665
database_cross_reference: CSP:0220-6201
database_cross_reference: DRUGBANK:DB00499
database_cross_reference: LCH_NW:sh91005137
database_cross_reference: LNC:LP57553-7
database_cross_reference: MEDCIN:48471
database_cross_reference: MMSL:42238
database_cross_reference: MMSL:4755
database_cross_reference: MMSL:d00240
database_cross_reference: MSH:D005485
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:76W6J0943E
database_cross_reference: NCI:C509
database_cross_reference: NCI_DCP:01895
database_cross_reference: NCI_DTP:NSC0215876
database_cross_reference: NCI_FDA:76W6J0943E
database_cross_reference: NCI_NCI-GLOSS:CDR0000045264
database_cross_reference: NDDF:002677
database_cross_reference: NDFRT:N0000007136
database_cross_reference: NDFRT:N0000147534
database_cross_reference: PDQ:CDR0000039811
database_cross_reference: RCD:he7..
database_cross_reference: RXNORM:4508
database_cross_reference: SNMI:C-A3120
database_cross_reference: SNOMEDCT_US:387587007
database_cross_reference: SNOMEDCT_US:96371003
database_cross_reference: USPMG:MTHU001423
database_cross_reference: VANDF:4019377

Prilocaine
type: Class
subclass of: Anilides
MCID: MC00010616
PMOID: PMO:00015837
Subclass_of: Anilides
Synonym: 2-(Propylamino)-O-propionotoluidide
Synonym: 2-Methyl-alpha-propylaminopropionanilide
Synonym: 4% Citanest Forte Dental With Epinephrine 1:200,000
Synonym: 4% Citanest Plain Dental
Synonym: 6,7-Epoxytropine Tropate
Synonym: Anodyne LPT
Synonym: Cadira Compliant Blood Stat
Synonym: Dentsply 4% Prilocaine Hydrochloride Dental Injection
Synonym: Dentsply 4% Prilocaine and Epinephrine Injection 1:200,000
Synonym: DermacinRx Cinlone-I CPI
Tree Number: T6.2.4.4.7
database_cross_reference: ATC:N01BB04
database_cross_reference: CHV:0000010109
database_cross_reference: DRUGBANK:DB00750
database_cross_reference: LNC:LP32686-5
database_cross_reference: LNC:MTHU016255
database_cross_reference: MMSL:5352
database_cross_reference: MMSL:d01396
database_cross_reference: MSH:D011318
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:046O35D44R
database_cross_reference: NCI:C47685
database_cross_reference: NCI_FDA:046O35D44R
database_cross_reference: NDDF:004574
database_cross_reference: NDFRT:N0000005730
database_cross_reference: NDFRT:N0000147987
database_cross_reference: RCD:x01AI
database_cross_reference: RXNORM:8686
database_cross_reference: SNM:E-7028
database_cross_reference: SNMI:C-6B060
database_cross_reference: SNOMEDCT_US:19232009
database_cross_reference: SNOMEDCT_US:387107003
database_cross_reference: USPMG:MTHU001103
database_cross_reference: VANDF:4019902

Propanil
type: Class
subclass of: Anilides
MCID: MC00010705
PMOID: PMO:00015838
Subclass_of: Anilides
Synonym: Propanamide, N-(3,4-dichlorophenyl)-
Synonym: Propanide
Synonym: Propanil [Chemical/Ingredient]
Tree Number: T6.2.4.4.8
database_cross_reference: MSH:D011411
database_cross_reference: NDFRT:N0000166897

Salicylanilides
type: Class
subclass of: Anilides
subclass of: Salicylamides
MCID: MC00011552
PMOID: PMO:00015839
Subclass_of: Anilides
Subclass_of: Salicylamides
Synonym: N Phenylsalicylamides
Synonym: N-Phenylsalicylamides
Synonym: PHENYLSALICYLAMIDES N
Synonym: Salicylanilides [Chemical/Ingredient]
Tree Number: T6.2.4.12.2
Tree Number: T6.2.4.4.9
database_cross_reference: LCH_NW:sh2006001589
database_cross_reference: MSH:D012458
database_cross_reference: NDFRT:N0000007578

Tocainide
type: Class
subclass of: Anilides
MCID: MC00043224
PMOID: PMO:00015843
Subclass_of: Anilides
Synonym: 2-Amino-2',6'-propionoxylidide
Synonym: 2-Amino-N-(2,6-dimethylphenyl)propionamid
Synonym: 2-amino-N-(2,6-Dimethylphenyl)propanamide
Synonym: Alanyl-2,6-xylidide
Synonym: Propanamide, 2-amino-N-(2,6-dimethylphenyl)-
Synonym: TOCAINIDE
Synonym: Tocainida
Synonym: Tocainide (product)
Synonym: Tocainide (substance)
Synonym: Tocainide [Chemical/Ingredient]
Tree Number: T6.2.4.4.10
database_cross_reference: ATC:C01BB03
database_cross_reference: CHV:0000015512
database_cross_reference: DRUGBANK:DB01056
database_cross_reference: LNC:LP16295-5
database_cross_reference: LNC:MTHU018215
database_cross_reference: MEDCIN:40574
database_cross_reference: MMSL:d00392
database_cross_reference: MSH:D016677
database_cross_reference: NCI:C66607
database_cross_reference: NCI_FDA:27DXO59SAN
database_cross_reference: NDDF:004482
database_cross_reference: NDFRT:N0000006535
database_cross_reference: NDFRT:N0000148035
database_cross_reference: RCD:x01QO
database_cross_reference: RXNORM:42359
database_cross_reference: SNMI:C-80480
database_cross_reference: SNOMEDCT_US:10555000
database_cross_reference: SNOMEDCT_US:372479006
database_cross_reference: VANDF:4019950

Encainide
type: Class
subclass of: Anilides
MCID: MC00043235
PMOID: PMO:00015844
Subclass_of: Anilides
Synonym: (+-)-2'-[2-(1-Methyl-2-piperidyl)ethyl]-P-anisanilide
Synonym: (+-)-4-Methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide
Synonym: 4-Methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
Synonym: 4-Methoxy-N-{2-[2-(1-methyl-piperidin-2-yl)-ethyl]-phenyl}-benzamide
Synonym: Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)-, (+-)-
Synonym: ENCAINIDE
Synonym: Encainida
Synonym: Encainide (product)
Synonym: Encainide (substance)
Synonym: Encainide [Chemical/Ingredient]
Tree Number: T6.2.4.4.11
database_cross_reference: ATC:C01BC08
database_cross_reference: DRUGBANK:DB01228
database_cross_reference: LNC:LP16127-0
database_cross_reference: LNC:MTHU016700
database_cross_reference: MEDCIN:42126
database_cross_reference: MSH:D016700
database_cross_reference: NCI:C65511
database_cross_reference: NCI_FDA:SY3J0147NB
database_cross_reference: NDDF:004486
database_cross_reference: NDFRT:N0000007247
database_cross_reference: NDFRT:N0000147836
database_cross_reference: RXNORM:42368
database_cross_reference: SNM:E-7677
database_cross_reference: SNMI:C-803D0
database_cross_reference: SNOMEDCT_US:372749000
database_cross_reference: SNOMEDCT_US:46479001
database_cross_reference: VANDF:4019745

Benzamides
type: Class
subclass of: Amides
MCID: MC00001563
PMOID: PMO:00015845
Subclass_of: Amides
Synonym: Benzamides [Chemical/Ingredient]
Synonym: benzamides
Tree Number: T6.2.4.5
database_cross_reference: AOD:0000020177
database_cross_reference: MSH:D001549
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007520

Imatinib Mesylate
type: Class
subclass of: Benzamides
subclass of: Piperazines
subclass of: Pyrimidines
MCID: MC00335991
PMOID: PMO:00015846
Subclass_of: Benzamides
Subclass_of: Piperazines
Subclass_of: Pyrimidines
Synonym: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide Monomethanesulfonate
Synonym: IMATINIB MESYLATE
Synonym: Imatinib Mesylate [Chemical/Ingredient]
Synonym: Imatinib Methanesulfonate
Synonym: Imatinib mesilate
Synonym: Imatinib mesylate
Synonym: Imatinib mesylate (substance)
Synonym: Mesylate, Imatinib
Synonym: Methanesulfonate, Imatinib
Synonym: imatinib (as imatinib mesylate)
Tree Number: T6.2.4.5.1
Tree Number: T6.3.5.15.4
Tree Number: T6.3.5.21.3
database_cross_reference: CHV:0000053000
database_cross_reference: DRUGBANK:DB00619
database_cross_reference: LNC:LP97866-5
database_cross_reference: LNC:MTHU035097
database_cross_reference: MMSL:16030
database_cross_reference: MMSL:238904
database_cross_reference: MSH:D000068877
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:8A1O1M485B
database_cross_reference: NCI:C1687
database_cross_reference: NCI_DCP:50363
database_cross_reference: NCI_FDA:8A1O1M485B
database_cross_reference: NCI_NCI-GLOSS:CDR0000044893
database_cross_reference: NDDF:009152
database_cross_reference: NDFRT:N0000148699
database_cross_reference: NDFRT:N0000191939
database_cross_reference: PDQ:CDR0000037862
database_cross_reference: RXNORM:284924
database_cross_reference: SNOMEDCT_US:129558005
database_cross_reference: USPMG:MTHU000505
database_cross_reference: VANDF:4021258

Bezafibrate
type: Class
subclass of: Benzamides
MCID: MC00001703
PMOID: PMO:00015847
Subclass_of: Benzamides
Synonym: 2-(P-(2-(P-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
Synonym: 2-(p-(2-(p-Chlorobenzamido)Ethyl)Phenoxy)-2-Methylpropionic Acid
Synonym: Act-bezafibrate SR
Synonym: BEZAFIBRATE
Synonym: Bezafibrat
Synonym: Bezafibrate (product)
Synonym: Bezafibrate (substance)
Synonym: Bezafibrate [Chemical/Ingredient]
Synonym: Bezafibrate product
Synonym: Bezafibrate product (product)
Tree Number: T6.2.4.5.2
database_cross_reference: ATC:C10AB02
database_cross_reference: CHV:0000001839
database_cross_reference: DRUGBANK:DB01393
database_cross_reference: MEDCIN:197692
database_cross_reference: MSH:D001629
database_cross_reference: NCI:C87449
database_cross_reference: NCI_FDA:Y9449Q51XH
database_cross_reference: NDDF:003937
database_cross_reference: NDFRT:N0000166742
database_cross_reference: RCD:bx1..
database_cross_reference: RXNORM:1525
database_cross_reference: SNOMEDCT_US:319937007
database_cross_reference: SNOMEDCT_US:363621005
database_cross_reference: SNOMEDCT_US:396025003

DEET
type: Class
subclass of: Benzamides
MCID: MC00003573
PMOID: PMO:00015848
Subclass_of: Benzamides
Synonym: Benzamide, N,N-diethyl-3-methyl-
Synonym: DEET N,N-DIETHYL-META-TOLUAMIDE
Synonym: DEET [Chemical/Ingredient]
Synonym: DET
Synonym: DETA
Synonym: DIETHYLTOLUAMIDE
Synonym: Deet
Synonym: Diethyl toluamide
Synonym: Diethyl toluamide (substance)
Synonym: Diethyltoluamide
Tree Number: T6.2.4.5.3
database_cross_reference: ATC:P03BX01
database_cross_reference: CHV:0000003654
database_cross_reference: CHV:0000027830
database_cross_reference: LCH_NW:sh2007003019
database_cross_reference: MSH:D003671
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:FB0C1XZV4Y
database_cross_reference: NCI:C80601
database_cross_reference: NCI_FDA:FB0C1XZV4Y
database_cross_reference: NDDF:003001
database_cross_reference: NDFRT:N0000023079
database_cross_reference: NDFRT:N0000166886
database_cross_reference: RXNORM:3129
database_cross_reference: SNM:E-6436
database_cross_reference: SNM:E-7445
database_cross_reference: SNMI:C-23408
database_cross_reference: SNMI:C-91172
database_cross_reference: SNOMEDCT_US:15414003
database_cross_reference: SNOMEDCT_US:16968005
database_cross_reference: VANDF:4021506

Dinitolmide
type: Class
subclass of: Benzamides
MCID: MC00003974
PMOID: PMO:00015849
Subclass_of: Benzamides
Synonym: 3,5-Dinitro-o-toluamide
Synonym: Benzamide, 2-methyl-3,5-dinitro-
Synonym: DINITOLMIDE
Synonym: Dinitolmide [Chemical/Ingredient]
Synonym: Dinitrotoluamide
Synonym: Methyldinitrobenzamide
Tree Number: T6.2.4.5.4
database_cross_reference: MSH:D004135
database_cross_reference: MTHSPL:AOX68RY4TV
database_cross_reference: NCI:C79128
database_cross_reference: NCI_FDA:AOX68RY4TV
database_cross_reference: NDFRT:N0000166884
database_cross_reference: RXNORM:1487907

Hippurates
type: Class
subclass of: Benzamides
subclass of: Keto Acids
MCID: MC00006278
PMOID: PMO:00015850
Subclass_of: Benzamides
Subclass_of: Keto Acids
Synonym: Hippurates [Chemical/Ingredient]
Synonym: hippurates
Tree Number: T6.2.12.7.2
Tree Number: T6.2.4.5.5
database_cross_reference: AOD:0000020178
database_cross_reference: MSH:D006626
database_cross_reference: MTH:U001982
database_cross_reference: NDFRT:N0000007609

Indoramin
type: Class
subclass of: Benzamides
subclass of: Piperidines
MCID: MC00006815
PMOID: PMO:00015854
Subclass_of: Benzamides
Subclass_of: Piperidines
Synonym: Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-
Synonym: INDORAMIN
Synonym: Indoramin (substance)
Synonym: Indoramin [Chemical/Ingredient]
Synonym: Indoramin product
Synonym: Indoramin product (product)
Synonym: Indoramin product (substance)
Synonym: Indoramina
Synonym: Indoramine
Synonym: Vidora
Tree Number: T6.2.4.5.6
Tree Number: T6.3.5.16.10
database_cross_reference: ATC:C02CA02
database_cross_reference: DRUGBANK:DB08950
database_cross_reference: MSH:D007217
database_cross_reference: NCI:C65916
database_cross_reference: NCI_FDA:0Z802HMY7H
database_cross_reference: NDDF:003737
database_cross_reference: NDFRT:N0000167199
database_cross_reference: RCD:x01CO
database_cross_reference: RXNORM:5784
database_cross_reference: SNOMEDCT_US:349913001
database_cross_reference: SNOMEDCT_US:395748009

Metoclopramide
type: Class
subclass of: Benzamides
MCID: MC00008257
PMOID: PMO:00015855
Subclass_of: Benzamides
Synonym: 2-Methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide
Synonym: 2-methoxy-5-chloroprocainamide
Synonym: 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide
Synonym: 4-amino-5-chloro-2-Methoxy-N-(beta-diethylaminoethyl)benzamide
Synonym: 4-amino-5-chloro-2-methoxy-N-(β-diethylaminoethyl)benzamide
Synonym: 4-amino-5-chloro-N-(2-(Diethylamino)ethyl)-2-methoxybenzamide
Synonym: 4-amino-5-chloro-N-(2-(Diethylamino)ethyl)-O-anisamide
Synonym: Apo-metoclop Tab 10mg
Synonym: Apo-metoclop Tab 5mg
Synonym: Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-
Tree Number: T6.2.4.5.7
database_cross_reference: AOD:0000020185
database_cross_reference: ATC:A03FA01
database_cross_reference: CCPSS:0042059
database_cross_reference: CHV:0000008069
database_cross_reference: CSP:1248-0970
database_cross_reference: CSP:2268-7470
database_cross_reference: DRUGBANK:DB01233
database_cross_reference: LNC:LP17995-9
database_cross_reference: LNC:LP62994-6
database_cross_reference: LNC:MTHU008221
database_cross_reference: MEDCIN:41955
database_cross_reference: MMSL:d00298
database_cross_reference: MSH:D008787
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:L4YEB44I46
database_cross_reference: NCI:C62046
database_cross_reference: NCI_FDA:L4YEB44I46
database_cross_reference: NCI_NCI-GLOSS:CDR0000045225
database_cross_reference: NDDF:004778
database_cross_reference: NDFRT:N0000005745
database_cross_reference: NDFRT:N0000147923
database_cross_reference: PDQ:CDR0000039502
database_cross_reference: RCD:a4h..
database_cross_reference: RCD:x019Y
database_cross_reference: RXNORM:6915
database_cross_reference: SNM:E-824X
database_cross_reference: SNMI:C-858A0
database_cross_reference: SNOMEDCT_US:123235001
database_cross_reference: SNOMEDCT_US:317170007
database_cross_reference: SNOMEDCT_US:372776000
database_cross_reference: SNOMEDCT_US:56549003
database_cross_reference: USPMG:MTHU000369
database_cross_reference: VANDF:4019835

Procainamide
type: Class
subclass of: Benzamides
MCID: MC00010638
PMOID: PMO:00015856
Subclass_of: Benzamides
Synonym: Amide, Procaine
Synonym: Apo-procainamide Cap 250mg
Synonym: Apo-procainamide Cap 375mg
Synonym: Apo-procainamide Cap 500mg
Synonym: Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-
Synonym: Benzamide, p-amino-N-(2-(diethylamino)ethyl)-
Synonym: PROCAINAMIDE
Synonym: Procainamida
Synonym: Procainamide (product)
Synonym: Procainamide (substance)
Tree Number: T6.2.4.5.8
database_cross_reference: AOD:0000019971
database_cross_reference: ATC:C01BA02
database_cross_reference: CCPSS:1012729
database_cross_reference: CHV:0000010137
database_cross_reference: CSP:2268-8208
database_cross_reference: DRUGBANK:DB01035
database_cross_reference: LNC:LP16261-7
database_cross_reference: LNC:LP32138-7
database_cross_reference: LNC:MTHU005035
database_cross_reference: MMSL:d00075
database_cross_reference: MSH:D011342
database_cross_reference: MTH:U002190
database_cross_reference: MTHSPL:L39WTC366D
database_cross_reference: NCI:C61905
database_cross_reference: NCI_DCP:50327
database_cross_reference: NCI_FDA:L39WTC366D
database_cross_reference: NDDF:004481
database_cross_reference: NDFRT:N0000005813
database_cross_reference: NDFRT:N0000147989
database_cross_reference: RCD:x01QM
database_cross_reference: RXNORM:8700
database_cross_reference: SNM:E-7671
database_cross_reference: SNMI:C-80440
database_cross_reference: SNOMEDCT_US:11959009
database_cross_reference: SNOMEDCT_US:372589008
database_cross_reference: USPMG:MTHU000905
database_cross_reference: VANDF:4019904

Procarbazine
type: Class
subclass of: Benzamides
MCID: MC00010640
PMOID: PMO:00015857
Subclass_of: Benzamides
Synonym: 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine
Synonym: 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine
Synonym: 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide
Synonym: Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-
Synonym: Benzethyzin
Synonym: Ibenzmethyzin
Synonym: Indicarb
Synonym: MIH
Synonym: N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide
Synonym: N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
Tree Number: T6.2.4.5.9
database_cross_reference: AOD:0000020186
database_cross_reference: ATC:L01XB01
database_cross_reference: CHV:0000010139
database_cross_reference: CSP:0316-4491
database_cross_reference: DRUGBANK:DB01168
database_cross_reference: MMSL:d00354
database_cross_reference: MSH:D011344
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:35S93Y190K
database_cross_reference: NCI:C62072
database_cross_reference: NCI:C773
database_cross_reference: NCI_FDA:35S93Y190K
database_cross_reference: NCI_NCI-GLOSS:CDR0000045378
database_cross_reference: NDDF:004827
database_cross_reference: NDFRT:N0000005818
database_cross_reference: NDFRT:N0000147991
database_cross_reference: PDQ:CDR0000041607
database_cross_reference: RCD:h57..
database_cross_reference: RXNORM:8702
database_cross_reference: SNM:E-8346
database_cross_reference: SNMI:C-781C0
database_cross_reference: SNMI:C-781C1
database_cross_reference: SNOMEDCT_US:10174003
database_cross_reference: SNOMEDCT_US:387474003
database_cross_reference: SNOMEDCT_US:81583003
database_cross_reference: USPMG:MTHU000477
database_cross_reference: VANDF:4019906

Sulpiride
type: Class
subclass of: Benzamides
MCID: MC00012426
PMOID: PMO:00015858
Subclass_of: Benzamides
Synonym: (+-)-Sulpiride
Synonym: 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide
Synonym: Benzamide, 5-(Aminosulfonyl)-N-((1-Ethyl-2-Pyrrolidinyl)Methyl)-2-Methoxy-
Synonym: Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-
Synonym: Bosnyl
Synonym: Dogmatyl
Synonym: Espiride
Synonym: Modal
Synonym: N-((1-Ethyl-2-Pyrrolidinyl)Methyl)-5-Sulfamoyl-O-Anisamide
Synonym: N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide
Tree Number: T6.2.4.5.10
database_cross_reference: AOD:0000020187
database_cross_reference: ATC:N05AL01
database_cross_reference: CHV:0000011882
database_cross_reference: CSP:4003-0013
database_cross_reference: DRUGBANK:DB00391
database_cross_reference: LNC:LP33040-4
database_cross_reference: LNC:MTHU015698
database_cross_reference: MEDCIN:340481
database_cross_reference: MSH:D013469
database_cross_reference: NCI:C87713
database_cross_reference: NCI_FDA:7MNE9M8287
database_cross_reference: NDDF:003764
database_cross_reference: NDFRT:N0000166882
database_cross_reference: PSY:50660
database_cross_reference: RCD:d4f..
database_cross_reference: RXNORM:10239
database_cross_reference: SNOMEDCT_US:321506004
database_cross_reference: SNOMEDCT_US:395891007

Remoxipride
type: Class
subclass of: Benzamides
MCID: MC00036616
PMOID: PMO:00015859
Subclass_of: Benzamides
Synonym: (S)-3-Bromo-N-((1-ethyl-2-pyrrolidinyl)methyl)-2,6-dimethoxybenzamide
Synonym: Benzamide, 3-bromo-N-((1-ethyl-2-pyrrolidinyl)methyl)-2,6-dimethoxy-, (S)-
Synonym: REMOXIPRIDE
Synonym: Remoxiprida
Synonym: Remoxipride (product)
Synonym: Remoxipride (substance)
Synonym: Remoxipride [Chemical/Ingredient]
Synonym: Remoxipridum
Synonym: Romoxipride
Synonym: remoxipride
Tree Number: T6.2.4.5.11
database_cross_reference: ATC:N05AL04
database_cross_reference: DRUGBANK:DB00409
database_cross_reference: MSH:D017330
database_cross_reference: NCI:C73312
database_cross_reference: NCI_FDA:0223RD59PE
database_cross_reference: NDDF:004031
database_cross_reference: NDFRT:N0000166887
database_cross_reference: RCD:x01Ba
database_cross_reference: RXNORM:35350
database_cross_reference: SNOMEDCT_US:349884002
database_cross_reference: SNOMEDCT_US:419361008

Cisapride
type: Class
subclass of: Benzamides
subclass of: Piperidines
MCID: MC00036530
PMOID: PMO:00015860
Subclass_of: Benzamides
Subclass_of: Piperidines
Synonym: (+-)-Cisapride
Synonym: 4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide
Synonym: 4-amino-5-chloro-N-(1-(3-(4-Fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide
Synonym: Benzamide, 4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy -4-piperidinyl)-2-methoxy-, cis-
Synonym: CISAPRIDE
Synonym: Cisaprid
Synonym: Cisaprida
Synonym: Cisapride (product)
Synonym: Cisapride (substance)
Synonym: Cisapride [Chemical/Ingredient]
Tree Number: T6.2.4.5.12
Tree Number: T6.3.5.16.31
database_cross_reference: ATC:A03FA02
database_cross_reference: CHV:0000014735
database_cross_reference: CSP:4001-0030
database_cross_reference: DRUGBANK:DB00604
database_cross_reference: LCH_NW:sh87006695
database_cross_reference: LNC:LP21146-3
database_cross_reference: LNC:MTHU012783
database_cross_reference: MEDCIN:71081
database_cross_reference: MMSL:4453
database_cross_reference: MMSL:d03166
database_cross_reference: MSH:D020117
database_cross_reference: MTHSPL:UVL329170W
database_cross_reference: NCI:C1210
database_cross_reference: NCI_FDA:UVL329170W
database_cross_reference: NDDF:003705
database_cross_reference: NDFRT:N0000006590
database_cross_reference: NDFRT:N0000148339
database_cross_reference: PDQ:CDR0000041689
database_cross_reference: RCD:dhj..
database_cross_reference: RXNORM:35255
database_cross_reference: SNMI:C-84990
database_cross_reference: SNOMEDCT_US:30317002
database_cross_reference: SNOMEDCT_US:387164008
database_cross_reference: VANDF:4020825

Raclopride
type: Class
subclass of: Benzamides
MCID: MC00036555
PMOID: PMO:00015861
Subclass_of: Benzamides
Synonym: Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)-methyl)-2-hydroxy-6-methoxy-
Synonym: Raclopride [Chemical/Ingredient]
Synonym: raclopride
Tree Number: T6.2.4.5.13
database_cross_reference: CSP:4008-0083
database_cross_reference: DRUGBANK:DB12518
database_cross_reference: MSH:D020891
database_cross_reference: NDFRT:N0000166885

Moclobemide
type: Class
subclass of: Benzamides
MCID: MC00031624
PMOID: PMO:00015862
Subclass_of: Benzamides
Synonym: 4-Chlor-N-(2-morpholinoethyl)benzamid
Synonym: 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide
Synonym: 4-Chloro-N-(2-morpholin-4-yl-ethyl)-benzamide
Synonym: Benzamide, 4-Chloro-N-(2-(4-Morpholinyl)Ethyl)-
Synonym: Benzamide, 4-Chloro-N-(2-(4-morpholinyl)ethyl)-
Synonym: Dom-moclobemide Tablets 150mg
Synonym: Dom-moclobemide Tablets 300mg
Synonym: MOCLOBEMIDE
Synonym: Manerix Tab 100mg
Synonym: Moclaime
Tree Number: T6.2.4.5.14
database_cross_reference: ATC:N06AG02
database_cross_reference: CHV:0000014417
database_cross_reference: DRUGBANK:DB01171
database_cross_reference: LCH_NW:sh87007396
database_cross_reference: LNC:LP31802-9
database_cross_reference: LNC:MTHU016081
database_cross_reference: MEDCIN:198815
database_cross_reference: MSH:D020912
database_cross_reference: NCI:C87772
database_cross_reference: NCI_FDA:PJ0Y7AZB63
database_cross_reference: NDDF:004179
database_cross_reference: NDFRT:N0000166883
database_cross_reference: PSY:31780
database_cross_reference: RCD:d85..
database_cross_reference: RXNORM:30121
database_cross_reference: SNOMEDCT_US:321911007
database_cross_reference: SNOMEDCT_US:395800003

Benzoylarginine-2-Naphthylamide
type: Class
subclass of: Amides
MCID: MC00001601
PMOID: PMO:00015863
Subclass_of: Amides
Synonym: 2 Naphthylamide, Benzoylarginine
Synonym: BANA
Synonym: BENZOYLARGININE NAPHTHYLAMIDE 02
Synonym: Benzamide, N-(4-((aminoiminomethyl)amino)-1-((2-naphthalenylamino)carbonyl)butyl)-, (+-)-
Synonym: Benzoylarginine 2 Naphthylamide
Synonym: Benzoylarginine beta Naphthylamide
Synonym: Benzoylarginine beta-Naphthylamide
Synonym: Benzoylarginine-2-Naphthylamide [Chemical/Ingredient]
Synonym: Naphthylamide, Benzoylarginine 2
Synonym: beta-Naphthylamide, Benzoylarginine
Tree Number: T6.2.4.6
database_cross_reference: MSH:D001587
database_cross_reference: NDFRT:N0000170229

Ceramides
type: Class
subclass of: Amides
MCID: MC00002496
PMOID: PMO:00015864
Subclass_of: Amides
Synonym: Ceramide
Synonym: Ceramide (lipids)
Synonym: Ceramide (substance)
Synonym: Ceramides [Chemical/Ingredient]
Synonym: N-Acyl Sphingosine
Synonym: ceramide
Synonym: ceramides
Tree Number: T6.2.4.7
database_cross_reference: AOD:0000020035
database_cross_reference: CHV:0000002643
database_cross_reference: CSP:2756-7851
database_cross_reference: LCH_NW:sh2002008720
database_cross_reference: MSH:D002518
database_cross_reference: NCI:C359
database_cross_reference: NCI_DCP:20107
database_cross_reference: NCI_NCI-GLOSS:CDR0000044999
database_cross_reference: NDDF:006805
database_cross_reference: NDFRT:N0000168602
database_cross_reference: PDQ:CDR0000038167
database_cross_reference: RCD:X80JP
database_cross_reference: RXNORM:2243
database_cross_reference: SNM:F-13820
database_cross_reference: SNMI:F-63820
database_cross_reference: SNOMEDCT_US:37112001

Cerebrosides
type: Class
subclass of: Ceramides
MCID: MC00002527
PMOID: PMO:00015865
Subclass_of: Ceramides
Synonym: Cerebroside
Synonym: Cerebroside (substance)
Synonym: Cerebrosides [Chemical/Ingredient]
Synonym: Gaucher lipid
Synonym: cerebroside
Tree Number: T6.2.4.7.1
database_cross_reference: CSP:1333-2638
database_cross_reference: LCH:U000907
database_cross_reference: LCH_NW:sh85022116
database_cross_reference: MSH:D002554
database_cross_reference: NDFRT:N0000168603
database_cross_reference: RCD:Xa9vk
database_cross_reference: SNM:F-13860
database_cross_reference: SNMI:F-63860
database_cross_reference: SNOMEDCT_US:53005004

Globosides
type: Class
subclass of: Ceramides
MCID: MC00005636
PMOID: PMO:00015868
Subclass_of: Ceramides
Synonym: Globoside
Synonym: Globoside (substance)
Synonym: Globoside, NOS
Synonym: Globosides [Chemical/Ingredient]
Synonym: globoside
Tree Number: T6.2.4.7.2
database_cross_reference: CHV:0000005529
database_cross_reference: CSP:1333-2530
database_cross_reference: MSH:D005915
database_cross_reference: NDFRT:N0000168608
database_cross_reference: RCD:X80JY
database_cross_reference: SNM:F-13950
database_cross_reference: SNMI:F-63950
database_cross_reference: SNOMEDCT_US:7030001

Lactosylceramides
type: Class
subclass of: Ceramides
MCID: MC00007343
PMOID: PMO:00015869
Subclass_of: Ceramides
Synonym: Ceramides, Lactosyl
Synonym: Lactosyl Ceramides
Synonym: Lactosylceramides [Chemical/Ingredient]
Tree Number: T6.2.4.7.3
database_cross_reference: MSH:D007790
database_cross_reference: NDFRT:N0000168606

Trihexosylceramides
type: Class
subclass of: Ceramides
MCID: MC00013093
PMOID: PMO:00015870
Subclass_of: Ceramides
Synonym: Ceramide Trihexosides
Synonym: Ceramides, Trihexosyl
Synonym: Trihexosides, Ceramide
Synonym: Trihexosyl Ceramides
Synonym: Trihexosylceramides [Chemical/Ingredient]
Tree Number: T6.2.4.7.4
database_cross_reference: MSH:D014281
database_cross_reference: MTH:U002326
database_cross_reference: NDFRT:N0000168607

Cerulenin
type: Class
subclass of: Amides
MCID: MC00002541
PMOID: PMO:00015871
Subclass_of: Amides
Synonym: (2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide
Synonym: (2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)oxirane-2-carboxamide
Synonym: 2,3-Epoxy-4-oxo-7,10-dodecadienoylamide
Synonym: Cerulenin [Chemical/Ingredient]
Synonym: Helicocerin
Synonym: Oxiranecarboxamide, 3-(1-oxo-4,7-nonadienyl)-, (2R-(2alpha,3alpha(4E,7E)))-
Tree Number: T6.2.4.8
database_cross_reference: DRUGBANK:DB01034
database_cross_reference: MSH:D002569
database_cross_reference: NDFRT:N0000166875

Dibucaine
type: Class
subclass of: Amides
MCID: MC00003847
PMOID: PMO:00015872
Subclass_of: Amides
Synonym: 2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide
Synonym: 2-Butoxy-N-(alpha-diethylaminoethyl)cinchoninamide
Synonym: 2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide
Synonym: 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide
Synonym: 2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide
Synonym: 2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide
Synonym: 2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide
Synonym: 4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-
Synonym: CINCHOCAINE
Synonym: CVS Hemorrhoidal Topical Analgesic
Tree Number: T6.2.4.9
database_cross_reference: ATC:C05AD04
database_cross_reference: ATC:D04AB02
database_cross_reference: ATC:N01BB06
database_cross_reference: ATC:S01HA06
database_cross_reference: ATC:S02DA04
database_cross_reference: CHV:0000003881
database_cross_reference: DRUGBANK:DB00527
database_cross_reference: LCH_NW:sh85093298
database_cross_reference: LNC:LP190766-8
database_cross_reference: LNC:LP20160-5
database_cross_reference: MEDCIN:40247
database_cross_reference: MEDCIN:40901
database_cross_reference: MMSL:4577
database_cross_reference: MMSL:5847
database_cross_reference: MSH:D003992
database_cross_reference: MTHSPL:L6JW2TJG99
database_cross_reference: NCI:C28984
database_cross_reference: NCI_FDA:L6JW2TJG99
database_cross_reference: NDDF:001371
database_cross_reference: NDFRT:N0000006372
database_cross_reference: NDFRT:N0000147191
database_cross_reference: RCD:x01AD
database_cross_reference: RXNORM:3339
database_cross_reference: SNM:E-7022
database_cross_reference: SNOMEDCT_US:349831001
database_cross_reference: SNOMEDCT_US:395953008
database_cross_reference: SNOMEDCT_US:39808001
database_cross_reference: VANDF:4018897

Formamides
type: Class
subclass of: Amides
MCID: MC00005266
PMOID: PMO:00015873
Subclass_of: Amides
Synonym: Formamides [Chemical/Ingredient]
Tree Number: T6.2.4.10
database_cross_reference: MSH:D005559
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166873

Dimethylformamide
type: Class
subclass of: Formamides
MCID: MC00003966
PMOID: PMO:00015874
Subclass_of: Formamides
Synonym: DMFA
Synonym: Dimethylformamide (substance)
Synonym: Dimethylformamide [Chemical/Ingredient]
Synonym: Formamide, N,N-dimethyl-
Synonym: N,N Dimethylformamide
Synonym: N,N-DIMETHYLFORMAMIDE
Synonym: N,N-Dimethylformamide
Synonym: N,N-Dimethylmethanamide
Synonym: N,N-dimethylformamide
Synonym: N-Formyldimethylamine
Tree Number: T6.2.4.10.1
database_cross_reference: DRUGBANK:DB01844
database_cross_reference: LCH_NW:sh91005517
database_cross_reference: LNC:LP14354-2
database_cross_reference: LNC:MTHU017555
database_cross_reference: MSH:D004126
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C83974
database_cross_reference: NCI_FDA:8696NH0Y2X
database_cross_reference: NDFRT:N0000166874
database_cross_reference: RCD:X80AB
database_cross_reference: SNM:E-5722
database_cross_reference: SNMI:C-21804
database_cross_reference: SNOMEDCT_US:71454009

Lactams
type: Class
subclass of: Amides
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00007325
PMOID: PMO:00015875
Subclass_of: Amides
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Lactam
Synonym: Lactams [Chemical/Ingredient]
Synonym: lactam
Synonym: lactams
Tree Number: T6.2.4.11
Tree Number: T6.3.5.11
database_cross_reference: CHV:0000007179
database_cross_reference: CSP:2074-8853
database_cross_reference: LCH:U002604
database_cross_reference: LCH_NW:sh85073858
database_cross_reference: MSH:D007769
database_cross_reference: NDFRT:N0000007642
database_cross_reference: SNOMEDCT_US:406778007

Caprolactam
type: Class
subclass of: Lactams
subclass of: Azepines
MCID: MC00002194
PMOID: PMO:00015876
Subclass_of: Azepines
Subclass_of: Lactams
Synonym: 2H-Azepin-2-one, hexahydro-
Synonym: Aminocaproic Lactam
Synonym: Caprolactam (substance)
Synonym: Caprolactam [Chemical/Ingredient]
Synonym: Hexahydro 2H Azepin 2 One
Synonym: Hexahydro-2H-Azepin-2-One
Synonym: Lactam, Aminocaproic
Tree Number: T6.2.4.11.1
Tree Number: T6.3.5.11.1
Tree Number: T6.3.5.2.1
database_cross_reference: LCH_NW:sh88007210
database_cross_reference: LNC:MTHU017573
database_cross_reference: MSH:D002209
database_cross_reference: NDFRT:N0000167246
database_cross_reference: SNMI:C-20641
database_cross_reference: SNOMEDCT_US:11238005

Lactams, Macrocyclic
type: Class
subclass of: Lactams
subclass of: Macrocyclic Compounds
MCID: MC00516310
PMOID: PMO:00015877
Subclass_of: Lactams
Subclass_of: Macrocyclic Compounds
Synonym: Cyclams
Synonym: Lactams, Macrocyclic [Chemical/Ingredient]
Synonym: Macrocyclic Lactams
Tree Number: T6.2.4.11.2
Tree Number: T6.4.5.7
database_cross_reference: MSH:D047029
database_cross_reference: NDFRT:N0000011415

beta-Lactams
type: Class
subclass of: Sulfur Compounds
subclass of: Lactams
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00098847
PMOID: PMO:00015878
Subclass_of: Heterocyclic Compounds, 2-Ring
Subclass_of: Lactams
Subclass_of: Sulfur Compounds
Synonym: BETA LACTAM
Synonym: Beta-lactam
Synonym: Beta-lactam (substance)
Synonym: beta Lactams
Synonym: beta lactam
Synonym: beta lactams
Synonym: beta-Lactams [Chemical/Ingredient]
Synonym: beta-lactam
Synonym: beta-lactams
Tree Number: T6.2.32.27
Tree Number: T6.2.4.11.3
Tree Number: T6.3.1.1.25
database_cross_reference: CCPSS:0011635
database_cross_reference: CHV:0000027521
database_cross_reference: LNC:LP173426-0
database_cross_reference: MSH:D047090
database_cross_reference: NDFRT:N0000011162
database_cross_reference: SNOMEDCT_US:406778007

Cephalosporins
type: Class
subclass of: Thiazines
MCID: MC00922457
PMOID: PMO:00015879
Subclass_of: Thiazines
Synonym: 530 MISCELLANEOUS CEPHALOSPORINS
Synonym: 530-535 CEPHALOSPORINS
Synonym: Antibiotics, Cephalosporin
Synonym: CEPHALOSPORINS
Synonym: Cephalosporin
Synonym: Cephalosporin -class of antibiotic-
Synonym: Cephalosporin -class of antibiotic- (product)
Synonym: Cephalosporin -class of antibiotic- (substance)
Synonym: Cephalosporin Antibiotic
Synonym: Cephalosporin Antibiotics
Tree Number: T6.2.32.12.1
database_cross_reference: CHV:0000002637
database_cross_reference: CSP:0199-6901
database_cross_reference: LCH:U000886
database_cross_reference: LCH_NW:sh85021981
database_cross_reference: LNC:LP65105-6
database_cross_reference: MEDCIN:45753
database_cross_reference: MSH:D002511
database_cross_reference: NCI:C357
database_cross_reference: NCI_NCI-GLOSS:CDR0000046676
database_cross_reference: NDFRT:N0000011161
database_cross_reference: RCD:x01HQ
database_cross_reference: SNM:E-7216
database_cross_reference: SNMI:C-53000
database_cross_reference: SNOMEDCT_US:373262009
database_cross_reference: SNOMEDCT_US:51779009

Monobactams
type: Class
subclass of: Lactams
subclass of: beta-Lactams
MCID: MC00008388
PMOID: PMO:00015910
Subclass_of: Lactams
Subclass_of: beta-Lactams
Synonym: 537 MISCELLANEOUS BETA-LACTAM ANTIBIOTICS
Synonym: Antibiotics, Monobactam
Synonym: Beta lactam antibiotics
Synonym: Beta-Lactam Antibiotic
Synonym: Beta-lactam antibiotic
Synonym: Beta-lactam antibiotic (substance)
Synonym: Lactam Antibiotics
Synonym: MISCELLANEOUS BETA-LACTAM ANTIBIOTICS
Synonym: Monobactam
Synonym: Monobactam (product)
Tree Number: T6.2.32.27.1
Tree Number: T6.3.5.11.2
database_cross_reference: AOD:0000019204
database_cross_reference: ATC:J01DF
database_cross_reference: CHV:0000008233
database_cross_reference: CSP:0199-5177
database_cross_reference: LCH_NW:sh86002798
database_cross_reference: MSH:D008997
database_cross_reference: NCI:C260
database_cross_reference: NDFRT:N0000011311
database_cross_reference: RCD:x01Hs
database_cross_reference: SNMI:C-53700
database_cross_reference: SNOMEDCT_US:373297006
database_cross_reference: SNOMEDCT_US:409132008
database_cross_reference: SNOMEDCT_US:409133003
database_cross_reference: SNOMEDCT_US:90614001

Moxalactam
type: Class
subclass of: Sulfides
MCID: MC00008440
PMOID: PMO:00015912
Subclass_of: Sulfides
Synonym: 5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((carboxy(4-hydroxyphenyl)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-
Synonym: 7-((Carboxy(4-Hydroxyphenyl)Acetyl)Amino)-7-Methoxy-(3-((1-Methyl-1h-Tetrazol-5-Yl)Thio)Methyl)-8-Oxo-5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
Synonym: LMOX
Synonym: Lamoxactam
Synonym: Latamoxef
Synonym: Latamoxef (product)
Synonym: Latamoxef (substance)
Synonym: Latamoxefum
Synonym: MOXALACTAM
Synonym: Moxalactam (product)
Tree Number: T6.2.32.7.2
database_cross_reference: AOD:0000019205
database_cross_reference: ATC:J01DD06
database_cross_reference: CHV:0000008294
database_cross_reference: DRUGBANK:DB04342
database_cross_reference: DRUGBANK:DB04570
database_cross_reference: LNC:LP16056-1
database_cross_reference: LNC:MTHU008458
database_cross_reference: MSH:D009070
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C66207
database_cross_reference: NCI:C670
database_cross_reference: NCI_FDA:VUF6C936Z3
database_cross_reference: NDDF:004889
database_cross_reference: NDFRT:N0000007187
database_cross_reference: NDFRT:N0000147933
database_cross_reference: PDQ:CDR0000039507
database_cross_reference: RCD:x01HS
database_cross_reference: RXNORM:7069
database_cross_reference: SNMI:C-53760
database_cross_reference: SNOMEDCT_US:17983007
database_cross_reference: SNOMEDCT_US:350135006
database_cross_reference: SNOMEDCT_US:387099009
database_cross_reference: VANDF:4019847

Penicillins
type: Class
subclass of: beta-Lactams
MCID: MC00009819
PMOID: PMO:00015913
Subclass_of: beta-Lactams
Synonym: 54 PENICILLINS
Synonym: Antibiotics, Penicillin
Synonym: BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Synonym: PENICILLINS
Synonym: Penicillin
Synonym: Penicillin -class of antibiotic-
Synonym: Penicillin -class of antibiotic- (product)
Synonym: Penicillin -class of antibiotic- (substance)
Synonym: Penicillin Antibiotic
Synonym: Penicillin Antibiotics
Tree Number: T6.2.32.27.2
database_cross_reference: ATC:J01C
database_cross_reference: CHV:0000009423
database_cross_reference: CSP:0199-8025
database_cross_reference: MEDCIN:40319
database_cross_reference: MSH:D010406
database_cross_reference: MTH:U002151
database_cross_reference: NCI:C1500
database_cross_reference: NCI_NCI-GLOSS:CDR0000045296
database_cross_reference: NDFRT:N0000011281
database_cross_reference: PSY:37190
database_cross_reference: RCD:x009C
database_cross_reference: SNMI:C-54000
database_cross_reference: SNOMEDCT_US:373270004
database_cross_reference: SNOMEDCT_US:6369005

Salicylamides
type: Class
subclass of: Amides
MCID: MC00011550
PMOID: PMO:00015943
Subclass_of: Amides
Synonym: Salicylamides [Chemical/Ingredient]
Synonym: salicylamide preparations
Synonym: salicylamide preparations (medication)
Tree Number: T6.2.4.12
database_cross_reference: MEDCIN:199661
database_cross_reference: MSH:D012457
database_cross_reference: NDFRT:N0000007577

Sulfonamides
type: Class
subclass of: Amides
subclass of: Sulfones
MCID: MC00012403
PMOID: PMO:00015944
Subclass_of: Amides
Subclass_of: Sulfones
Synonym: SULFONAMIDE
Synonym: Sulfonamide
Synonym: Sulfonamide (substance)
Synonym: Sulfonamides [Chemical/Ingredient]
Synonym: Sulphonamide
Synonym: sulfonamide
Synonym: sulfonamides
Synonym: sulfonilamide
Synonym: sulphonamide
Synonym: sulphonamides
Tree Number: T6.2.32.8.4
Tree Number: T6.2.4.13
database_cross_reference: CCPSS:0019395
database_cross_reference: CHV:0000011868
database_cross_reference: CSP:2840-2172
database_cross_reference: LCH_NW:sh85130353
database_cross_reference: LNC:LP97420-1
database_cross_reference: MSH:D013449
database_cross_reference: MTH:U002277
database_cross_reference: NDFRT:N0000008048
database_cross_reference: SNOMEDCT_US:387406002
database_cross_reference: USPMG:MTHU002166

Celecoxib
type: Class
subclass of: Sulfonamides
MCID: MC00169196
PMOID: PMO:00015945
Subclass_of: Sulfonamides
Synonym: 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
Synonym: Accel-celecoxib
Synonym: Act Celecoxib
Synonym: Ag-celecoxib
Synonym: Apo-celecoxib
Synonym: Articox
Synonym: Articoxib
Synonym: Artiflex
Synonym: Artilog
Synonym: Artix
Tree Number: T6.2.4.13.1
database_cross_reference: ATC:L01XX33
database_cross_reference: ATC:M01AH01
database_cross_reference: CHV:0000038485
database_cross_reference: CSP:1040-0769
database_cross_reference: CSP:4007-0090
database_cross_reference: DRUGBANK:DB00482
database_cross_reference: LNC:LP28519-4
database_cross_reference: LNC:MTHU013163
database_cross_reference: MEDCIN:133342
database_cross_reference: MMSL:174627
database_cross_reference: MMSL:7872
database_cross_reference: MMSL:d04380
database_cross_reference: MSH:D000068579
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:JCX84Q7J1L
database_cross_reference: NCI:C1728
database_cross_reference: NCI_DCP:09260
database_cross_reference: NCI_DTP:NSC0719627
database_cross_reference: NCI_FDA:JCX84Q7J1L
database_cross_reference: NCI_NCI-GLOSS:CDR0000045969
database_cross_reference: NDDF:007731
database_cross_reference: NDFRT:N0000007233
database_cross_reference: NDFRT:N0000148596
database_cross_reference: PDQ:CDR0000043023
database_cross_reference: RXNORM:140587
database_cross_reference: SNOMEDCT_US:116081000
database_cross_reference: SNOMEDCT_US:330166009
database_cross_reference: SNOMEDCT_US:370187009
database_cross_reference: USPMG:MTHU000046
database_cross_reference: VANDF:4021143

Sildenafil Citrate
type: Class
subclass of: Sulfonamides
subclass of: Piperazines
MCID: MC00246772
PMOID: PMO:00015946
Subclass_of: Piperazines
Subclass_of: Sulfonamides
Synonym: 1-((3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Synonym: Citrate, Sildenafil
Synonym: SILDENAFIL CITRATE
Synonym: Sildenafil Citrate [Chemical/Ingredient]
Synonym: Sildenafil citrate
Synonym: Sildenafil citrate (product)
Synonym: Sildenafil citrate (substance)
Synonym: sildenafil (as citrate)
Synonym: sildenafil citrate
Synonym: sildenafil citrate (medication)
Tree Number: T6.2.4.13.2
Tree Number: T6.3.5.15.2
database_cross_reference: CHV:0000046499
database_cross_reference: DRUGBANK:DB00203
database_cross_reference: LNC:LP28528-5
database_cross_reference: LNC:MTHU013331
database_cross_reference: MEDCIN:132931
database_cross_reference: MMSL:194438
database_cross_reference: MMSL:29679
database_cross_reference: MMSL:5460
database_cross_reference: MSH:D000068677
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:BW9B0ZE037
database_cross_reference: NCI:C26670
database_cross_reference: NCI_DCP:20611
database_cross_reference: NCI_FDA:BW9B0ZE037
database_cross_reference: NDDF:007449
database_cross_reference: NDFRT:N0000148549
database_cross_reference: NDFRT:N0000191931
database_cross_reference: PDQ:CDR0000269137
database_cross_reference: RXNORM:221161
database_cross_reference: SNOMEDCT_US:108482004
database_cross_reference: SNOMEDCT_US:397226003
database_cross_reference: USPMG:MTHU001247
database_cross_reference: VANDF:4021093

Rosuvastatin Calcium
type: Class
subclass of: Sulfonamides
subclass of: Pyrimidines
MCID: MC00368326
PMOID: PMO:00015947
Subclass_of: Pyrimidines
Subclass_of: Sulfonamides
Synonym: Calcium, Rosuvastatin
Synonym: HMG-CoA reductase inhibitors rosuvastatin calcium
Synonym: ROSUVASTATIN CALCIUM
Synonym: Rosuvastatin Calcium [Chemical/Ingredient]
Synonym: Rosuvastatin calcium
Synonym: Rosuvastatin calcium (substance)
Synonym: rosuvastatin calcium
Synonym: rosuvastatin calcium (medication)
Tree Number: T6.2.4.13.3
Tree Number: T6.3.5.21.2
database_cross_reference: CHV:0000054656
database_cross_reference: DRUGBANK:DB01098
database_cross_reference: MEDCIN:258092
database_cross_reference: MMSL:107656
database_cross_reference: MMSL:17536
database_cross_reference: MSH:D000068718
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:83MVU38M7Q
database_cross_reference: NCI:C61933
database_cross_reference: NCI_FDA:83MVU38M7Q
database_cross_reference: NCI_NCI-GLOSS:CDR0000663321
database_cross_reference: NDDF:009903
database_cross_reference: NDFRT:N0000191941
database_cross_reference: RXNORM:323828
database_cross_reference: SNOMEDCT_US:406435003
database_cross_reference: USPMG:MTHU001009

Darunavir
type: Class
subclass of: Sulfonamides
subclass of: Furans
MCID: MC00510193
PMOID: PMO:00015948
Subclass_of: Furans
Subclass_of: Sulfonamides
Synonym: (3-((4-aminobenzenesulfonyl)isobutylamino)-1-benzyl-2-hydroxypropyl)carbamic acid hexahydrofuro(2,3-b)furan-3-yl ester
Synonym: (3R,3AS,6ar)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(1)-isobutylsulfanilamido)propyl)carbamate
Synonym: (3R,3AS,6ar)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate
Synonym: (3R,3AS,6ar)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
Synonym: (3R,3AS,6ar)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-neopentylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
Synonym: (3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate
Synonym: DARUNAVIR
Synonym: Darunavir (product)
Synonym: Darunavir (substance)
Synonym: Darunavir [Chemical/Ingredient]
Tree Number: T6.2.4.13.4
Tree Number: T6.3.5.10.1
database_cross_reference: ATC:J05AE10
database_cross_reference: DRUGBANK:DB01264
database_cross_reference: LNC:LP64724-5
database_cross_reference: LNC:MTHU026540
database_cross_reference: MEDCIN:302448
database_cross_reference: MMSL:d05825
database_cross_reference: MSH:D000069454
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:YO603Y8113
database_cross_reference: NCI:C65364
database_cross_reference: NCI_FDA:YO603Y8113
database_cross_reference: NDDF:011599
database_cross_reference: NDFRT:N0000175996
database_cross_reference: NDFRT:N0000179778
database_cross_reference: RXNORM:460132
database_cross_reference: SNOMEDCT_US:423888002
database_cross_reference: SNOMEDCT_US:424096001
database_cross_reference: USPMG:MTHU002701
database_cross_reference: VANDF:4025441

Benzolamide
type: Class
subclass of: Sulfonamides
MCID: MC00001588
PMOID: PMO:00015949
Subclass_of: Sulfonamides
Synonym: 1,3,4-Thiadiazole-2-sulfonamide, 5-((phenylsulfonyl)amino)-
Synonym: 1,3,4-Thiadiazole-2-sulfonamide, 5-benzenesulfonamido- (6CI)
Synonym: 2-(Phenylsulfonylamino)-1,3,4-thiadiazole-5-sulfonamide
Synonym: 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
Synonym: BENZOLAMIDE
Synonym: Benzolamide [Chemical/Ingredient]
Synonym: W 1803
Tree Number: T6.2.4.13.5
database_cross_reference: DRUGBANK:DB07050
database_cross_reference: MSH:D001574
database_cross_reference: NCI:C96537
database_cross_reference: NCI_FDA:FC5AAH89R5
database_cross_reference: NDFRT:N0000167091

Bumetanide
type: Class
subclass of: Sulfonamides
MCID: MC00002009
PMOID: PMO:00015950
Subclass_of: Sulfonamides
Synonym: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Synonym: 3-Butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid
Synonym: 3-Butylamino-4-phenoxy-5-sulfamoyl-benzoic acid
Synonym: 3-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid
Synonym: BUMETANIDE
Synonym: Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-
Synonym: Bumetanida
Synonym: Bumetanide (product)
Synonym: Bumetanide (substance)
Synonym: Bumetanide [Chemical/Ingredient]
Tree Number: T6.2.4.13.6
database_cross_reference: ATC:C03CA02
database_cross_reference: CHV:0000002219
database_cross_reference: CSP:2840-3310
database_cross_reference: DRUGBANK:DB00887
database_cross_reference: LCH:U000712
database_cross_reference: LCH_NW:sh85017982
database_cross_reference: LNC:LP16052-0
database_cross_reference: LNC:MTHU006833
database_cross_reference: MEDCIN:41882
database_cross_reference: MMSL:3606
database_cross_reference: MMSL:4304
database_cross_reference: MMSL:d00179
database_cross_reference: MSH:D002034
database_cross_reference: MTHSPL:0Y2S3XUQ5H
database_cross_reference: NCI:C28875
database_cross_reference: NCI_FDA:0Y2S3XUQ5H
database_cross_reference: NDDF:002312
database_cross_reference: NDFRT:N0000007386
database_cross_reference: NDFRT:N0000146155
database_cross_reference: RCD:b32..
database_cross_reference: RXNORM:1808
database_cross_reference: SNMI:C-72020
database_cross_reference: SNOMEDCT_US:387498005
database_cross_reference: SNOMEDCT_US:86647004
database_cross_reference: USPMG:MTHU000962
database_cross_reference: VANDF:4017794

Chlorthalidone
type: Class
subclass of: Sulfonamides
subclass of: Phthalimides
subclass of: Benzophenones
MCID: MC00002692
PMOID: PMO:00015951
Subclass_of: Benzophenones
Subclass_of: Phthalimides
Subclass_of: Sulfonamides
Synonym: 1-keto-3-(3'-Sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline
Synonym: 1-oxo-3-(3-Sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline
Synonym: 2-chloro-5-(1-Hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide
Synonym: 2-chloro-5-(2,3-dihydro-1-Hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide
Synonym: 3-(4'-chloro-3'-Sulfamoylphenyl)-3-hydroxyphthalimidine
Synonym: 3-Hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine
Synonym: Apo Chlorthalidone Tab 100mg
Synonym: Apo-atenidone
Synonym: Benzenesulfonamide, 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-
Synonym: Benzenesulfonamide, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-
Tree Number: T6.2.18.4.1
Tree Number: T6.2.20.3.1
Tree Number: T6.2.4.13.7
database_cross_reference: ATC:C03BA04
database_cross_reference: CHV:0000002846
database_cross_reference: CSP:2840-3294
database_cross_reference: DRUGBANK:DB00310
database_cross_reference: LCH:U000983
database_cross_reference: LCH_NW:sh85024593
database_cross_reference: LNC:LP16077-7
database_cross_reference: LNC:MTHU006890
database_cross_reference: MEDCIN:40543
database_cross_reference: MMSL:4364
database_cross_reference: MMSL:4432
database_cross_reference: MMSL:d00192
database_cross_reference: MSH:D002752
database_cross_reference: MTHSPL:Q0MQD1073Q
database_cross_reference: NCI:C47449
database_cross_reference: NCI_DCP:01647
database_cross_reference: NCI_FDA:Q0MQD1073Q
database_cross_reference: NDDF:002309
database_cross_reference: NDFRT:N0000006970
database_cross_reference: NDFRT:N0000146240
database_cross_reference: RCD:b23..
database_cross_reference: RXNORM:2409
database_cross_reference: SNM:E-8893
database_cross_reference: SNMI:C-72240
database_cross_reference: SNOMEDCT_US:387324004
database_cross_reference: SNOMEDCT_US:57893000
database_cross_reference: USPMG:MTHU000980
database_cross_reference: VANDF:4017887

Clopamide
type: Class
subclass of: Sulfonamides
subclass of: Piperidines
MCID: MC00002973
PMOID: PMO:00015952
Subclass_of: Piperidines
Subclass_of: Sulfonamides
Synonym: 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide
Synonym: Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-, cis-
Synonym: CLOPAMIDE
Synonym: Clopamide (product)
Synonym: Clopamide (substance)
Synonym: Clopamide [Chemical/Ingredient]
Synonym: Clopamide [ingred see bdek.]
Synonym: Clopamide [ingredient see bdek.]
Synonym: Clopamide [ingredient see bdek.] (product)
Synonym: Clopamide [ingredient see bdek.] (substance)
Tree Number: T6.2.4.13.8
Tree Number: T6.3.5.16.4
database_cross_reference: ATC:C03BA03
database_cross_reference: CHV:0000003063
database_cross_reference: DRUGBANK:DB13792
database_cross_reference: MSH:D003005
database_cross_reference: NCI:C81074
database_cross_reference: NCI_FDA:17S83WON0I
database_cross_reference: NDDF:003711
database_cross_reference: NDFRT:N0000167202
database_cross_reference: RCD:b24..
database_cross_reference: RXNORM:2603
database_cross_reference: SNOMEDCT_US:317937003
database_cross_reference: SNOMEDCT_US:395940005
database_cross_reference: SNOMEDCT_US:429462003

Dichlorphenamide
type: Class
subclass of: Sulfonamides
MCID: MC00003861
PMOID: PMO:00015953
Subclass_of: Sulfonamides
Synonym: 1,3-Benzenedisulfonamide, 4,5-dichloro-
Synonym: 1,3-Disulfamyl-4,5-dichlorobenzene
Synonym: 1,3-disulfamoyl-4,5-dichlorobenzene
Synonym: 3,4-Dichloro-5-sulfamylbenzenesulfonamide
Synonym: 4,5-DICHLOROBENZENE-1,3-disulfonamide
Synonym: 4,5-Dichloro-1,3-benzenedisulfonamide
Synonym: 4,5-Dichloro-benzene-1,3-disulfonic acid diamide
Synonym: 4,5-dichloro-1,3-disulfamoylbenzene
Synonym: 4,5-dichloro-m-benzenedisulfonamide
Synonym: DICHLORPHENAMIDE
Tree Number: T6.2.4.13.9
database_cross_reference: ATC:S01EC02
database_cross_reference: CHV:0000003888
database_cross_reference: DRUGBANK:DB01144
database_cross_reference: LNC:LP16111-4
database_cross_reference: LNC:MTHU016578
database_cross_reference: MEDCIN:44712
database_cross_reference: MMSL:4581
database_cross_reference: MMSL:d00639
database_cross_reference: MSH:D004005
database_cross_reference: MTHSPL:VVJ6673MHY
database_cross_reference: NCI:C65376
database_cross_reference: NCI_FDA:VVJ6673MHY
database_cross_reference: NDDF:002288
database_cross_reference: NDFRT:N0000007475
database_cross_reference: NDFRT:N0000146279
database_cross_reference: RCD:k87..
database_cross_reference: RXNORM:3353
database_cross_reference: SNM:E-8894
database_cross_reference: SNMI:C-97920
database_cross_reference: SNOMEDCT_US:19583005
database_cross_reference: SNOMEDCT_US:387111009
database_cross_reference: VANDF:4017928

Ethoxzolamide
type: Class
subclass of: Sulfonamides
subclass of: Thiazoles
MCID: MC00004788
PMOID: PMO:00015954
Subclass_of: Sulfonamides
Subclass_of: Thiazoles
Synonym: 2-Benzothiazolesulfonamide, 6-ethoxy-
Synonym: 6-Ethoxy-1,3-benzothiazole-2-sulfonamide
Synonym: 6-Ethoxy-2-benzothiazolesulfonamide
Synonym: Cardrase
Synonym: ETHOXZOLAMIDE
Synonym: Ethoxazolamide
Synonym: Ethoxyzolamide
Synonym: Ethoxyzolamide (substance)
Synonym: Ethoxzolamide [Chemical/Ingredient]
Synonym: ethoxzolamide
Tree Number: T6.2.32.13.7
Tree Number: T6.2.4.13.10
database_cross_reference: DRUGBANK:DB00311
database_cross_reference: MEDCIN:197666
database_cross_reference: MSH:D005016
database_cross_reference: NCI:C65561
database_cross_reference: NCI_FDA:Z52H4811WX
database_cross_reference: NDDF:002290
database_cross_reference: NDFRT:N0000167096
database_cross_reference: SNM:E-8897
database_cross_reference: SNMI:C-72085
database_cross_reference: SNOMEDCT_US:63203003

Indapamide
type: Class
subclass of: Sulfonamides
MCID: MC00006792
PMOID: PMO:00015955
Subclass_of: Sulfonamides
Synonym: Apo-indapamide 1.25 Mg Tablets
Synonym: Apo-indapamide 2.5mg Tablets
Synonym: Arcosyl Plus
Synonym: Arcosyl Plus Ld
Synonym: Arifon
Synonym: Bajaten
Synonym: Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-
Synonym: Coversyl Plus
Synonym: Coversyl Plus Hd
Synonym: Coversyl Plus Ld
Tree Number: T6.2.4.13.11
database_cross_reference: ATC:C03BA11
database_cross_reference: CHV:0000006651
database_cross_reference: DRUGBANK:DB00808
database_cross_reference: MEDCIN:48821
database_cross_reference: MMSL:2360
database_cross_reference: MMSL:4873
database_cross_reference: MMSL:d00260
database_cross_reference: MSH:D007190
database_cross_reference: MTHSPL:F089I0511L
database_cross_reference: NCI:C29119
database_cross_reference: NCI_DCP:32078
database_cross_reference: NCI_FDA:F089I0511L
database_cross_reference: NDDF:002313
database_cross_reference: NDFRT:N0000006274
database_cross_reference: NDFRT:N0000147050
database_cross_reference: RCD:b28..
database_cross_reference: RXNORM:5764
database_cross_reference: SNMI:C-72010
database_cross_reference: SNOMEDCT_US:387419003
database_cross_reference: SNOMEDCT_US:74213004
database_cross_reference: USPMG:MTHU000983
database_cross_reference: VANDF:4018746

Mafenide
type: Class
subclass of: Sulfonamides
MCID: MC00007814
PMOID: PMO:00015956
Subclass_of: Sulfonamides
Synonym: 4 Homosulfanilamide
Synonym: 4-(Aminomethyl)benzenesulfonamide
Synonym: 4-(aminomethyl)benzenesulfonamide
Synonym: 4-Homosufanilamide
Synonym: 4-Homosulfanilamide
Synonym: Ambamide
Synonym: Bensulfamide
Synonym: Benzenesulfonamide, 4-(aminomethyl)-
Synonym: HOMOSULFANILAMIDE 4
Synonym: MAFENIDE
Tree Number: T6.2.4.13.12
database_cross_reference: ATC:D06BA03
database_cross_reference: DRUGBANK:DB06795
database_cross_reference: LNC:LP19442-0
database_cross_reference: LNC:MTHU009174
database_cross_reference: MSH:D008272
database_cross_reference: MTHSPL:58447S8P4L
database_cross_reference: NCI:C61819
database_cross_reference: NCI_FDA:58447S8P4L
database_cross_reference: NDDF:004960
database_cross_reference: NDFRT:N0000006329
database_cross_reference: NDFRT:N0000146586
database_cross_reference: RCD:mc4..
database_cross_reference: RXNORM:6572
database_cross_reference: SNM:E-7163
database_cross_reference: SNMI:C-90260
database_cross_reference: SNOMEDCT_US:372876009
database_cross_reference: SNOMEDCT_US:84737005
database_cross_reference: USPMG:MTHU001114
database_cross_reference: VANDF:4018256

Mefruside
type: Class
subclass of: Sulfonamides
MCID: MC00007975
PMOID: PMO:00015957
Subclass_of: Sulfonamides
Synonym: 1,3-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-((tetrahydro-2-methyl-2-furanyl)methyl)-
Synonym: Mefruside (product)
Synonym: Mefruside (substance)
Synonym: Mefruside [Chemical/Ingredient]
Synonym: mefruside
Tree Number: T6.2.4.13.13
database_cross_reference: ATC:C03BA05
database_cross_reference: MSH:D008529
database_cross_reference: NDDF:004000
database_cross_reference: NDFRT:N0000166872
database_cross_reference: RCD:b29..
database_cross_reference: RXNORM:6696
database_cross_reference: SNOMEDCT_US:317957004
database_cross_reference: SNOMEDCT_US:406772008

Metolazone
type: Class
subclass of: Sulfonamides
MCID: MC00008258
PMOID: PMO:00015958
Subclass_of: Sulfonamides
Synonym: 2-Methyl-3-O-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
Synonym: 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
Synonym: 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-
Synonym: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
Synonym: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-O-tolyl-6-quinazolinesulfonamide
Synonym: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide
Synonym: Diurem
Synonym: METOLAZONE
Synonym: Metadure
Synonym: Metolaz
Tree Number: T6.2.4.13.14
database_cross_reference: ATC:C03BA08
database_cross_reference: CHV:0000008070
database_cross_reference: CSP:0394-7343
database_cross_reference: DRUGBANK:DB00524
database_cross_reference: LNC:LP17954-6
database_cross_reference: LNC:MTHU003340
database_cross_reference: MEDCIN:40611
database_cross_reference: MMSL:47402
database_cross_reference: MMSL:5101
database_cross_reference: MMSL:d00299
database_cross_reference: MSH:D008788
database_cross_reference: MTHSPL:TZ7V40X7VX
database_cross_reference: NCI:C650
database_cross_reference: NCI_DCP:32079
database_cross_reference: NCI_FDA:TZ7V40X7VX
database_cross_reference: NDDF:002310
database_cross_reference: NDFRT:N0000005746
database_cross_reference: NDFRT:N0000146498
database_cross_reference: RCD:b2b..
database_cross_reference: RXNORM:6916
database_cross_reference: SNM:E-8909
database_cross_reference: SNMI:C-72290
database_cross_reference: SNOMEDCT_US:22198003
database_cross_reference: SNOMEDCT_US:387123003
database_cross_reference: USPMG:MTHU000985
database_cross_reference: VANDF:4018161

Probenecid
type: Class
subclass of: Sulfonamides
MCID: MC00010635
PMOID: PMO:00015959
Subclass_of: Sulfonamides
Synonym: 4-((Dipropylamino)sulfonyl)benzoic acid
Synonym: 4-(Di-N-propylsulfamoyl)benzoesaeure
Synonym: 4-(N,N-Dipropylsulfamoyl)benzoesaeure
Synonym: Benemid Tab 500mg
Synonym: Benzoic acid, 4-((dipropylamino)sulfonyl)-
Synonym: P-(Dipropylsulfamoyl)benzoic acid
Synonym: PROB
Synonym: PROBENECID
Synonym: Pro Biosan Kit
Synonym: Probalan
Tree Number: T6.2.4.13.15
database_cross_reference: AOD:0000020189
database_cross_reference: ATC:M04AB01
database_cross_reference: CHV:0000010133
database_cross_reference: CSP:2840-3387
database_cross_reference: DRUGBANK:DB01032
database_cross_reference: LNC:LP16260-9
database_cross_reference: LNC:MTHU007603
database_cross_reference: MEDCIN:40220
database_cross_reference: MMSL:128
database_cross_reference: MMSL:5356
database_cross_reference: MMSL:d00031
database_cross_reference: MSH:D011339
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:PO572Z7917
database_cross_reference: NCI:C772
database_cross_reference: NCI_DTP:NSC0018786
database_cross_reference: NCI_FDA:PO572Z7917
database_cross_reference: NCI_NCI-GLOSS:CDR0000045288
database_cross_reference: NDDF:002321
database_cross_reference: NDFRT:N0000005795
database_cross_reference: NDFRT:N0000146225
database_cross_reference: PDQ:CDR0000040223
database_cross_reference: PSY:40535
database_cross_reference: RCD:j63..
database_cross_reference: RXNORM:8698
database_cross_reference: SNM:E-8982
database_cross_reference: SNMI:C-72610
database_cross_reference: SNOMEDCT_US:387365004
database_cross_reference: SNOMEDCT_US:66094001
database_cross_reference: USPMG:MTHU000409
database_cross_reference: VANDF:4017872

Sulfasalazine
type: Class
subclass of: Sulfonamides
MCID: MC00011555
PMOID: PMO:00015960
Subclass_of: Sulfonamides
Synonym: 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid
Synonym: 2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid
Synonym: 2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic Acid
Synonym: 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene
Synonym: 5-((P-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid
Synonym: 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid
Synonym: 5-(P-(2-Pyridylsulfamyl)phenylazo)salicylic acid
Synonym: Apo Sulfasalazine Tab 500mg
Synonym: Asasurfan
Synonym: Azulfdidina
Tree Number: T6.2.4.13.16
database_cross_reference: AOD:0000020190
database_cross_reference: ATC:A07EC01
database_cross_reference: CHV:0000011000
database_cross_reference: CSP:2832-5379
database_cross_reference: DRUGBANK:DB00795
database_cross_reference: LNC:LP18088-2
database_cross_reference: LNC:MTHU003000
database_cross_reference: LNC:MTHU006799
database_cross_reference: MEDCIN:40926
database_cross_reference: MMSL:2061
database_cross_reference: MMSL:5528
database_cross_reference: MMSL:d00379
database_cross_reference: MSH:D012460
database_cross_reference: MTHSPL:3XC8GUZ6CB
database_cross_reference: NCI:C29469
database_cross_reference: NCI_DCP:00800
database_cross_reference: NCI_FDA:3XC8GUZ6CB
database_cross_reference: NDDF:002832
database_cross_reference: NDFRT:N0000006054
database_cross_reference: NDFRT:N0000146249
database_cross_reference: RCD:aa6..
database_cross_reference: RCD:j55..
database_cross_reference: RCD:x02L9
database_cross_reference: RCDAE:aa6..
database_cross_reference: RCDAE:j55..
database_cross_reference: RXNORM:9524
database_cross_reference: SNM:E-7190
database_cross_reference: SNMI:C-55960
database_cross_reference: SNOMEDCT_US:317422008
database_cross_reference: SNOMEDCT_US:330038003
database_cross_reference: SNOMEDCT_US:363635007
database_cross_reference: SNOMEDCT_US:387248006
database_cross_reference: SNOMEDCT_US:45844004
database_cross_reference: USPMG:MTHU001525
database_cross_reference: VANDF:4017897

Sulfanilamides
type: Class
subclass of: Sulfonamides
subclass of: Aniline Compounds
MCID: MC00012372
PMOID: PMO:00015961
Subclass_of: Aniline Compounds
Subclass_of: Sulfonamides
Synonym: Sulfanilamides [Chemical/Ingredient]
Tree Number: T6.2.4.13.17
Tree Number: T6.2.6.5.16
database_cross_reference: LCH_NW:sh2007003930
database_cross_reference: MSH:D013424
database_cross_reference: NDFRT:N0000008034

Sulfaguanidine
type: Class
subclass of: Guanidines
MCID: MC00012361
PMOID: PMO:00015969
Subclass_of: Guanidines
Synonym: Benzenesulfonamide, 4-amino-N-(aminoiminomethyl)-
Synonym: Gastro Entericanis Biocanina
Synonym: Gastro-Entericanis Biocanina
Synonym: GastroEntericanis Biocanina
Synonym: SULFAGUANIDINE
Synonym: Sulfaguanidine (product)
Synonym: Sulfaguanidine (substance)
Synonym: Sulfaguanidine [Chemical/Ingredient]
Synonym: Sulfanilylguanidine
Synonym: Sulphaguanidine
Tree Number: T6.2.5.3.12
database_cross_reference: ATC:A07AB03
database_cross_reference: CHV:0000011849
database_cross_reference: LCH_NW:sh2007003953
database_cross_reference: MSH:D013414
database_cross_reference: NCI:C76977
database_cross_reference: NCI_FDA:15XQ8043FN
database_cross_reference: NDDF:002839
database_cross_reference: NDFRT:N0000166871
database_cross_reference: RCD:eca..
database_cross_reference: RCDAE:eca..
database_cross_reference: RXNORM:10174
database_cross_reference: SNM:E-7183
database_cross_reference: SNMI:C-559BA
database_cross_reference: SNOMEDCT_US:387500006
database_cross_reference: SNOMEDCT_US:86939001

Trimethoprim, Sulfamethoxazole Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00013114
PMOID: PMO:00015975
Subclass_of: Drug Combinations
Synonym: Bactrimel
Synonym: Benzenesulfonamide, 4-a)mino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl-2,4-pyrimidinediamine
Synonym: Centran
Synonym: Centrin
Synonym: Co Trimoxazole
Synonym: Co-Trimoxazole
Synonym: Co-trimazole
Synonym: Co-trimoxazole
Synonym: Co-trimoxazole (product)
Synonym: Co-trimoxazole (substance)
Tree Number: T6.15.3.20
database_cross_reference: ATC:J01EE01
database_cross_reference: CCPSS:1003806
database_cross_reference: CHV:0000012574
database_cross_reference: DRUGBANK:DB00440
database_cross_reference: DRUGBANK:DB01015
database_cross_reference: LCH_NW:sh85027289
database_cross_reference: LNC:LP16302-9
database_cross_reference: LNC:MTHU008494
database_cross_reference: MEDCIN:41535
database_cross_reference: MMSL:2044
database_cross_reference: MMSL:d00124
database_cross_reference: MSH:D015662
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C909
database_cross_reference: NCI_DTP:NSC0618652
database_cross_reference: NCI_NCI-GLOSS:CDR0000045244
database_cross_reference: NCI_NCI-GLOSS:CDR0000046089
database_cross_reference: NDFRT:N0000020114
database_cross_reference: NDFRT:N0000167190
database_cross_reference: PDQ:CDR0000039724
database_cross_reference: RCD:ec1..
database_cross_reference: RCD:ec2..
database_cross_reference: RCD:x02Lv
database_cross_reference: RXNORM:10831
database_cross_reference: SNMI:C-52020
database_cross_reference: SNOMEDCT_US:13939004
database_cross_reference: SNOMEDCT_US:324356006
database_cross_reference: SNOMEDCT_US:324367007
database_cross_reference: SNOMEDCT_US:387079003
database_cross_reference: SNOMEDCT_US:398731002
database_cross_reference: SNOMEDCT_US:703745000
database_cross_reference: USPMG:MTHU000202
database_cross_reference: VANDF:4022108

Sulfathiazoles
type: Class
subclass of: Thiazoles
MCID: MC00012381
PMOID: PMO:00015982
Subclass_of: Thiazoles
Synonym: Sulfathiazoles [Chemical/Ingredient]
Tree Number: T6.2.32.13.14
database_cross_reference: LCH_NW:sh2007003949
database_cross_reference: MSH:D013432
database_cross_reference: NDFRT:N0000008036

Xipamide
type: Class
subclass of: Sulfonamides
MCID: MC00013765
PMOID: PMO:00015986
Subclass_of: Sulfonamides
Synonym: 4-Chloro-5-Sulfamoyl-2',6'-Salicyloxylidide
Synonym: Benzamide, 5-(Aminosulfonyl)-4-Chloro-N-(2,6-Dimethylphenyl)-2-Hydroxy-
Synonym: Benzamide, 5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-
Synonym: XIPAMIDE
Synonym: Xipamid
Synonym: Xipamide (product)
Synonym: Xipamide (substance)
Synonym: Xipamide [Chemical/Ingredient]
Synonym: xipamid
Synonym: xipamide
Tree Number: T6.2.4.13.18
database_cross_reference: ATC:C03BA10
database_cross_reference: CHV:0000013238
database_cross_reference: LNC:LP35744-9
database_cross_reference: LNC:MTHU018597
database_cross_reference: MEDCIN:197670
database_cross_reference: MSH:D014988
database_cross_reference: NCI:C87708
database_cross_reference: NCI_FDA:4S9EY0NUEC
database_cross_reference: NDDF:004068
database_cross_reference: NDFRT:N0000166859
database_cross_reference: RCD:b2d..
database_cross_reference: RXNORM:11371
database_cross_reference: SNOMEDCT_US:317968004
database_cross_reference: SNOMEDCT_US:395923001

Sumatriptan
type: Class
subclass of: Sulfonamides
MCID: MC00038573
PMOID: PMO:00015987
Subclass_of: Sulfonamides
Synonym: (3-[2-(dimethylamino)Ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide
Synonym: 1-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide
Synonym: 1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-
Synonym: 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide
Synonym: 3-(2-(dimethylamino)Ethyl)-N-methyl-1H-indole-5-methanesulfonamide
Synonym: 3-[2-(dimethylamino)Ethyl]-N-methylindole-5-methanesulfonamide
Synonym: Act Sumatriptan
Synonym: Adracon
Synonym: Altaxa
Synonym: Apigrane
Tree Number: T6.2.4.13.19
database_cross_reference: ATC:N02CC01
database_cross_reference: CHV:0000014885
database_cross_reference: CSP:5001-0017
database_cross_reference: DRUGBANK:DB00669
database_cross_reference: LCH_NW:sh96010267
database_cross_reference: LNC:LP28529-3
database_cross_reference: LNC:MTHU013332
database_cross_reference: MEDCIN:258069
database_cross_reference: MMSL:166806
database_cross_reference: MMSL:31925
database_cross_reference: MMSL:d03160
database_cross_reference: MSH:D018170
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:8R78F6L9VO
database_cross_reference: NCI:C1240
database_cross_reference: NCI_FDA:8R78F6L9VO
database_cross_reference: NDDF:004044
database_cross_reference: NDFRT:N0000007273
database_cross_reference: NDFRT:N0000148514
database_cross_reference: RCD:dl7..
database_cross_reference: RXNORM:37418
database_cross_reference: SNOMEDCT_US:322822007
database_cross_reference: SNOMEDCT_US:350311006
database_cross_reference: SNOMEDCT_US:395892000
database_cross_reference: USPMG:MTHU000434
database_cross_reference: VANDF:4021050

Thioamides
type: Class
subclass of: Sulfur Compounds
subclass of: Amides
MCID: MC00012725
PMOID: PMO:00015988
Subclass_of: Amides
Subclass_of: Sulfur Compounds
Synonym: Thioamide
Synonym: Thioamide (substance)
Synonym: Thioamides [Chemical/Ingredient]
Synonym: thioamide
Synonym: thioamides
Tree Number: T6.2.32.15
Tree Number: T6.2.4.14
database_cross_reference: AOD:0000020198
database_cross_reference: CHV:0000012185
database_cross_reference: CSP:2903-5246
database_cross_reference: MSH:D013854
database_cross_reference: NDFRT:N0000166888
database_cross_reference: SNOMEDCT_US:406762005

Polyunsaturated Alkamides
type: Class
subclass of: Amides
MCID: MC00583147
PMOID: PMO:00015989
Subclass_of: Amides
Synonym: Alkamides, Polyunsaturated
Synonym: Alkylamides, Polyunsaturated
Synonym: Polyunsaturated Alkamides [Chemical/Ingredient]
Synonym: Polyunsaturated Alkylamides
Tree Number: T6.2.4.15
database_cross_reference: MSH:D053284
database_cross_reference: NDFRT:N0000175092

Capsaicin
type: Class
subclass of: Polyunsaturated Alkamides
subclass of: Solanaceous Alkaloids
MCID: MC00002197
PMOID: PMO:00015990
Subclass_of: Polyunsaturated Alkamides
Subclass_of: Solanaceous Alkaloids
Synonym: (E)-8-Methyl-N-vanillyl-6-nonenamide
Synonym: (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
Synonym: (E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide
Synonym: 2-Count HEAT PATCHES
Synonym: 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-
Synonym: 8 Methyl N Vanillyl 6 Nonenamide
Synonym: 8-Methyl-N-Vanillyl-6-Nonenamide
Synonym: Adazin
Synonym: Aflexeryl-MC
Synonym: Alegenix Biofrequency Chip
Tree Number: T6.2.4.15.1
Tree Number: T6.3.3.18.2
database_cross_reference: AOD:0000020523
database_cross_reference: ATC:M02AB01
database_cross_reference: ATC:N01BX04
database_cross_reference: CHV:0000002373
database_cross_reference: CSP:4000-0137
database_cross_reference: DRUGBANK:DB06774
database_cross_reference: LCH:U000776
database_cross_reference: LCH_NW:sh85020016
database_cross_reference: MMSL:4346
database_cross_reference: MMSL:6074
database_cross_reference: MSH:D002211
database_cross_reference: MTHSPL:S07O44R1ZM
database_cross_reference: NCI:C339
database_cross_reference: NCI_CRCH:C339
database_cross_reference: NCI_DCP:00534
database_cross_reference: NCI_DTP:NSC0056353
database_cross_reference: NCI_FDA:S07O44R1ZM
database_cross_reference: NCI_NCI-GLOSS:CDR0000045377
database_cross_reference: NDDF:001988
database_cross_reference: NDFRT:N0000007430
database_cross_reference: NDFRT:N0000147626
database_cross_reference: PDQ:CDR0000041591
database_cross_reference: PSY:07475
database_cross_reference: RCD:X7956
database_cross_reference: RXNORM:1992
database_cross_reference: SNMI:C-30379
database_cross_reference: SNOMEDCT_US:400416009
database_cross_reference: SNOMEDCT_US:95995002
database_cross_reference: VANDF:4019506

Amidines
type: Class
subclass of: Organic Chemicals
MCID: MC00000716
PMOID: PMO:00015991
Subclass_of: Organic Chemicals
Synonym: Amidine
Synonym: Amidine (substance)
Synonym: Amidines [Chemical/Ingredient]
Synonym: amidine
Tree Number: T6.2.5
database_cross_reference: CSP:0114-0657
database_cross_reference: LCH:U000188
database_cross_reference: LCH_NW:sh85004465
database_cross_reference: MSH:D000578
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008167
database_cross_reference: SNOMEDCT_US:413501004

Benzamidines
type: Class
subclass of: Amidines
MCID: MC00001564
PMOID: PMO:00015992
Subclass_of: Amidines
Synonym: Benzamidines [Chemical/Ingredient]
Tree Number: T6.2.5.1
database_cross_reference: MSH:D001550
database_cross_reference: NDFRT:N0000007523

Diminazene
type: Class
subclass of: Benzamidines
subclass of: Triazenes
MCID: MC00003972
PMOID: PMO:00015993
Subclass_of: Benzamidines
Subclass_of: Triazenes
Synonym: 4,4' Diazoaminobenzamidine
Synonym: 4,4'-(1-Triazene-1,3-diyl)bis-benzenecarboximidamide
Synonym: 4,4'-Diazoaminobenzamidine
Synonym: Benzenecarboximidamide, 4,4'-(1-triazene-1,3-diyl)bis-
Synonym: DIMINAZENE
Synonym: Diminazene [Chemical/Ingredient]
Tree Number: T6.2.33.2
Tree Number: T6.2.5.1.1
database_cross_reference: DRUGBANK:DB03608
database_cross_reference: MSH:D004133
database_cross_reference: NCI:C65409
database_cross_reference: NCI_FDA:Y5G36EEA5Z
database_cross_reference: NDFRT:N0000166580

Pentamidine
type: Class
subclass of: Benzamidines
MCID: MC00009828
PMOID: PMO:00015994
Subclass_of: Benzamidines
Synonym: 1,5-Bis(4-amidinophenoxy)pentane
Synonym: 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide
Synonym: 4,4'-(Pentamethylenedioxy)dibenzamidine
Synonym: 4,4'-Diamidinodiphenoxypentane
Synonym: Aerosolized Pentamadine
Synonym: Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-
Synonym: P,P'-(pentamethylenedioxy)dibenzamidine
Synonym: PENTAMIDINE
Synonym: Pentacarinat 300 Inj Pws 300mg/vial
Synonym: Pentacrinat
Tree Number: T6.2.5.1.2
database_cross_reference: CCPSS:0044660
database_cross_reference: CHV:0000009436
database_cross_reference: CSP:0114-0900
database_cross_reference: DRUGBANK:DB00738
database_cross_reference: MEDCIN:40396
database_cross_reference: MMSL:7933
database_cross_reference: MMSL:d00030
database_cross_reference: MSH:D010419
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:673LC5J4LQ
database_cross_reference: NCI:C731
database_cross_reference: NCI_DTP:NSC0009921
database_cross_reference: NCI_FDA:673LC5J4LQ
database_cross_reference: NCI_NCI-GLOSS:CDR0000630950
database_cross_reference: NDFRT:N0000005709
database_cross_reference: NDFRT:N0000147966
database_cross_reference: PDQ:CDR0000040324
database_cross_reference: RCD:x01JH
database_cross_reference: RXNORM:7994
database_cross_reference: SNM:E-7361
database_cross_reference: SNMI:C-52050
database_cross_reference: SNOMEDCT_US:31692006
database_cross_reference: SNOMEDCT_US:372699006
database_cross_reference: USPMG:MTHU000567
database_cross_reference: VANDF:4019881

Chlorphenamidine
type: Class
subclass of: Amidines
MCID: MC00002681
PMOID: PMO:00015995
Subclass_of: Amidines
Synonym: (EZ)-N2-(4-chloro-o-tolyl)-N1,N1-dimethylformamidine
Synonym: Chlordimeform
Synonym: Chlordimeform (substance)
Synonym: Chlorphenamidine [Chemical/Ingredient]
Synonym: Methanimidamide, N'-(4-chloro-2-methylphenyl)-N,N-dimethyl-
Synonym: N'-(4-chloro-2-methylphenyl)-N,N-dimethylmethanimidamide
Tree Number: T6.2.5.2
database_cross_reference: MSH:D002742
database_cross_reference: NDFRT:N0000166592
database_cross_reference: SNOMEDCT_US:441838009

Guanidines
type: Class
subclass of: Amidines
MCID: MC00005868
PMOID: PMO:00015996
Subclass_of: Amidines
Synonym: Guanidines [Chemical/Ingredient]
Synonym: guanidine
Tree Number: T6.2.5.3
database_cross_reference: CSP:1356-9885
database_cross_reference: MSH:D006146
database_cross_reference: MTH:U001969
database_cross_reference: NDFRT:N0000008038

Agmatine
type: Class
subclass of: Guanidines
MCID: MC00000470
PMOID: PMO:00015997
Subclass_of: Guanidines
Synonym: (4-aminobutyl) guanidine
Synonym: (4-aminobutyl)guanidine
Synonym: 1 Amino 4 guanidinobutane
Synonym: 1-Amino-4-guanidinobutane
Synonym: 1-amino-4-guanidobutane
Synonym: 4-(Aminobutyl)guanidine
Synonym: Agmatine [Chemical/Ingredient]
Synonym: Guanidine, (4-aminobutyl)-
Synonym: N-(4-aminobutyl)guanidine
Tree Number: T6.2.5.3.1
database_cross_reference: DRUGBANK:DB08838
database_cross_reference: LCH_NW:sh2003008321
database_cross_reference: MSH:D000376
database_cross_reference: NDFRT:N0000166582

Bethanidine
type: Class
subclass of: Guanidines
MCID: MC00001702
PMOID: PMO:00015998
Subclass_of: Guanidines
Synonym: BETHANIDINE
Synonym: Betanidina
Synonym: Betanidine
Synonym: Betanidinum
Synonym: Bethanidine (product)
Synonym: Bethanidine (substance)
Synonym: Bethanidine [Chemical/Ingredient]
Synonym: Esbatal
Synonym: Guanidine, N,N'-dimethyl-N''-(phenylmethyl)-
Synonym: N,N'-dimethyl-N''-(phenylmethyl)-guanidine
Tree Number: T6.2.5.3.2
database_cross_reference: ATC:C02CC01
database_cross_reference: DRUGBANK:DB00217
database_cross_reference: MSH:D001627
database_cross_reference: NCI:C81343
database_cross_reference: NCI_FDA:W8S3YM7AUU
database_cross_reference: NDDF:003935
database_cross_reference: NDFRT:N0000166585
database_cross_reference: RCD:x01QY
database_cross_reference: RXNORM:1523
database_cross_reference: SNOMEDCT_US:350601007
database_cross_reference: SNOMEDCT_US:418981008

Biguanides
type: Class
subclass of: Guanidines
MCID: MC00001710
PMOID: PMO:00015999
Subclass_of: Guanidines
Synonym: Biguanide
Synonym: Biguanide (product)
Synonym: Biguanide (substance)
Synonym: Biguanides [Chemical/Ingredient]
Synonym: biguanide
Synonym: biguanides
Tree Number: T6.2.5.3.3
database_cross_reference: CHV:0000001850
database_cross_reference: DRUGBANK:DB13100
database_cross_reference: LCH:U000555
database_cross_reference: LCH_NW:sh85013986
database_cross_reference: MSH:D001645
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007698
database_cross_reference: RCD:f4...
database_cross_reference: SNOMEDCT_US:109082004
database_cross_reference: SNOMEDCT_US:373306007

Sitagliptin Phosphate, Metformin Hydrochloride Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC01007813
PMOID: PMO:00016004
Subclass_of: Drug Combinations
Synonym: Sitagliptin Phosphate Metformin Hydrochloride Drug Combination
Synonym: Sitagliptin Phosphate, Metformin Hydrochloride Drug Combination [Chemical/Ingredient]
Synonym: Sitagliptin Phosphate-Metformin Hydrochloride Drug Combination
Tree Number: T6.15.3.11
database_cross_reference: MSH:D000068899
database_cross_reference: NDFRT:N0000192004

Cimetidine
type: Class
subclass of: Guanidines
MCID: MC00002907
PMOID: PMO:00016006
Subclass_of: Guanidines
Synonym: 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine
Synonym: 2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine
Synonym: Acid Reducer
Synonym: Apo Cimetidine Tab 200mg
Synonym: Apo Cimetidine Tab 300mg
Synonym: Apo Cimetidine Tab 400mg
Synonym: Apo Cimetidine Tab 600mg
Synonym: Apo-cimetidine Oral Solution
Synonym: Apo-cimetidine Tab 800mg
Synonym: CIMETIDINE
Tree Number: T6.2.5.3.4
database_cross_reference: AOD:0000020847
database_cross_reference: ATC:A02BA01
database_cross_reference: CHV:0000002994
database_cross_reference: CSP:1357-0225
database_cross_reference: DRUGBANK:DB00501
database_cross_reference: LCH:U001024
database_cross_reference: LCH_NW:sh85025995
database_cross_reference: LNC:LP16078-5
database_cross_reference: LNC:MTHU004923
database_cross_reference: MEDCIN:40859
database_cross_reference: MMSL:101
database_cross_reference: MMSL:4448
database_cross_reference: MMSL:d00140
database_cross_reference: MSH:D002927
database_cross_reference: MTHSPL:80061L1WGD
database_cross_reference: NCI:C374
database_cross_reference: NCI_DCP:01655
database_cross_reference: NCI_FDA:80061L1WGD
database_cross_reference: NCI_NCI-GLOSS:CDR0000045184
database_cross_reference: NDDF:003415
database_cross_reference: NDFRT:N0000007007
database_cross_reference: NDFRT:N0000147147
database_cross_reference: PDQ:CDR0000039185
database_cross_reference: PSY:09225
database_cross_reference: RCD:a61..
database_cross_reference: RXNORM:2541
database_cross_reference: SNM:E-8207
database_cross_reference: SNMI:C-84010
database_cross_reference: SNOMEDCT_US:373541007
database_cross_reference: SNOMEDCT_US:83532008
database_cross_reference: USPMG:MTHU001189
database_cross_reference: VANDF:4018845

Creatine
type: Class
subclass of: Guanidines
subclass of: PMO:00021256
MCID: MC00003325
PMOID: PMO:00016007
Subclass_of: Amino Acids
Subclass_of: Guanidines
Synonym: ((amino(Imino)methyl)(methyl)amino)acetic acid
Synonym: (N-methylcarbamimidamido)acetic acid
Synonym: (alpha-Methylguanido)acetic acid
Synonym: (α-methylguanido)acetic acid
Synonym: CREATINE
Synonym: Creatin
Synonym: Creatine (substance)
Synonym: Creatine [Chemical/Ingredient]
Synonym: Glycine, N-(aminoiminomethyl)-N-methyl-
Synonym: Kreatin
Tree Number: T6.10.1.13
Tree Number: T6.2.5.3.5
database_cross_reference: AOD:0000018554
database_cross_reference: CHV:0000003436
database_cross_reference: CSP:0124-2448
database_cross_reference: DRUGBANK:DB00148
database_cross_reference: LCH:U001195
database_cross_reference: LCH_NW:sh85033819
database_cross_reference: LNC:LP15509-0
database_cross_reference: LNC:LP32032-2
database_cross_reference: LNC:MTHU005167
database_cross_reference: MMSL:d04417
database_cross_reference: MSH:D003401
database_cross_reference: MTH:U001833
database_cross_reference: MTHSPL:MU72812GK0
database_cross_reference: NCI:C37937
database_cross_reference: NCI_FDA:MU72812GK0
database_cross_reference: NCI_NCI-GLOSS:CDR0000377706
database_cross_reference: NDDF:008272
database_cross_reference: NDFRT:N0000023110
database_cross_reference: NDFRT:N0000170276
database_cross_reference: PDQ:CDR0000361777
database_cross_reference: RCD:X80N4
database_cross_reference: RXNORM:2907
database_cross_reference: SNM:F-11380
database_cross_reference: SNMI:F-61380
database_cross_reference: SNOMEDCT_US:14804005
database_cross_reference: VANDF:4024927

Guanabenz
type: Class
subclass of: Guanidines
MCID: MC00005863
PMOID: PMO:00016008
Subclass_of: Guanidines
Synonym: 2,6 Dichlorobenzylideneaminoguanidine
Synonym: 2,6-Dichlorobenzylideneaminoguanidine
Synonym: GUANABENZ
Synonym: Guanabenz (product)
Synonym: Guanabenz (substance)
Synonym: Guanabenz [Chemical/Ingredient]
Synonym: Guanabenzo
Synonym: Guanabenzum
Synonym: Hydrazinecarboximidamide, 2-((2,6-dichlorophenyl)methylene)-
Synonym: Lisapres
Tree Number: T6.2.5.3.6
database_cross_reference: DRUGBANK:DB00629
database_cross_reference: MMSL:d00130
database_cross_reference: MSH:D006143
database_cross_reference: MTHSPL:GGD30112WC
database_cross_reference: NCI:C83740
database_cross_reference: NCI_FDA:GGD30112WC
database_cross_reference: NDDF:004496
database_cross_reference: NDFRT:N0000006937
database_cross_reference: NDFRT:N0000147859
database_cross_reference: RXNORM:5033
database_cross_reference: SNMI:C-81150
database_cross_reference: SNOMEDCT_US:372867002
database_cross_reference: SNOMEDCT_US:82951001
database_cross_reference: VANDF:4019768

Guanethidine
type: Class
subclass of: Guanidines
MCID: MC00005866
PMOID: PMO:00016009
Subclass_of: Guanidines
Synonym: ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine
Synonym: (2-(Octahydro-1-azocinyl)ethyl)guanidine
Synonym: (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine
Synonym: 2-(1'-Azacyclooctyl)ethylguanidine
Synonym: 2-(1-N,N-Heptamethyleneimino)ethylguanidine
Synonym: Apo Guanethidine Sulfate Tab 10mg
Synonym: Apo Guanethidine Sulfate Tab 25mg
Synonym: Azocine, 1-(2-guanidinoethyl)octahydro-
Synonym: GUANETHIDINE
Synonym: Guanethidine (product)
Tree Number: T6.2.5.3.7
database_cross_reference: ATC:C02CC02
database_cross_reference: ATC:S01EX01
database_cross_reference: CHV:0000005728
database_cross_reference: CSP:0570-1869
database_cross_reference: CSP:1356-9885
database_cross_reference: DRUGBANK:DB01170
database_cross_reference: LCH_NW:sh88007115
database_cross_reference: MEDCIN:257698
database_cross_reference: MMSL:d00131
database_cross_reference: MSH:D006145
database_cross_reference: NCI:C65830
database_cross_reference: NCI_FDA:ZTI6C33Q2Q
database_cross_reference: NDDF:004524
database_cross_reference: NDFRT:N0000006941
database_cross_reference: NDFRT:N0000147861
database_cross_reference: PSY:21930
database_cross_reference: RCD:x01Qa
database_cross_reference: RXNORM:5036
database_cross_reference: SNM:E-7636
database_cross_reference: SNMI:C-81170
database_cross_reference: SNOMEDCT_US:387456007
database_cross_reference: SNOMEDCT_US:79305004
database_cross_reference: VANDF:4019770

Methylguanidine
type: Class
subclass of: Guanidines
MCID: MC00008230
PMOID: PMO:00016010
Subclass_of: Guanidines
Synonym: Guanidine, methyl-
Synonym: Methylguanidine [Chemical/Ingredient]
Synonym: methylguanidine
Tree Number: T6.2.5.3.8
database_cross_reference: CSP:1357-0597
database_cross_reference: MSH:D008760
database_cross_reference: NDFRT:N0000166584

Mitoguazone
type: Class
subclass of: Guanidines
MCID: MC00008351
PMOID: PMO:00016011
Subclass_of: Guanidines
Synonym: Hydrazinecarboximidamide, 2,2'-(1-methyl-1,2-ethanediylidene)bis-
Synonym: MGBG
Synonym: MGGH
Synonym: MITOGUAZONE
Synonym: Me-GAG
Synonym: Methyl-G
Synonym: Methylglyoxal Bis(guanylhydrazone)
Tree Number: T6.2.5.3.9
database_cross_reference: ATC:L01XX16
database_cross_reference: CHV:0000008184
database_cross_reference: CSP:1359-4234
database_cross_reference: DRUGBANK:DB12967
database_cross_reference: MSH:D008935
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C661
database_cross_reference: NCI_DCP:50544
database_cross_reference: NCI_FDA:OD5Q0L447W
database_cross_reference: NDDF:006109
database_cross_reference: NDFRT:N0000166583
database_cross_reference: PDQ:CDR0000039500

Nitrosoguanidines
type: Class
subclass of: Guanidines
subclass of: Nitroso Compounds
MCID: MC00008960
PMOID: PMO:00016012
Subclass_of: Guanidines
Subclass_of: Nitroso Compounds
Synonym: Nitrosoguanidines [Chemical/Ingredient]
Synonym: nitrosoguanidine
Tree Number: T6.2.26.2
Tree Number: T6.2.5.3.10
database_cross_reference: CSP:1357-0686
database_cross_reference: MSH:D009604
database_cross_reference: NDFRT:N0000166745

Methylnitronitrosoguanidine
type: Class
subclass of: Nitrosoguanidines
MCID: MC00008239
PMOID: PMO:00016013
Subclass_of: Nitrosoguanidines
Synonym: 1-Methyl-3-nitro-1-nitrosoguanidine
Synonym: Guanidine, N-methyl-N'-nitro-N-nitroso-
Synonym: MNG
Synonym: MNNG
Synonym: Methylnitronitrosoguanidine [Chemical/Ingredient]
Synonym: Methylnitrosonitroguanidine
Synonym: N Methyl N' nitro N nitrosoguanidine
Synonym: N methyl N' nitro N nitrosoguanidine
Synonym: N'-nitro-N-nitroso-N-methylguanidine
Synonym: N-Methyl-N'-nitro-N-nitrosoguanidine
Tree Number: T6.2.26.2.1
database_cross_reference: CSP:4000-0262
database_cross_reference: MSH:D008769
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44415
database_cross_reference: NDFRT:N0000166746

Robenidine
type: Class
subclass of: Guanidines
MCID: MC00011481
PMOID: PMO:00016014
Subclass_of: Guanidines
Synonym: Carbonimidic dihydrazide, bis((4-chlorophenyl)methylene)-
Synonym: ROBENIDINE
Synonym: Robenidine [Chemical/Ingredient]
Tree Number: T6.2.5.3.11
database_cross_reference: MSH:D012370
database_cross_reference: MTHSPL:4888ME6C4E
database_cross_reference: NCI:C76427
database_cross_reference: NCI_FDA:4888ME6C4E
database_cross_reference: NDFRT:N0000166589
database_cross_reference: RXNORM:1311554

Guanfacine
type: Class
subclass of: Guanidines
MCID: MC00041105
PMOID: PMO:00016015
Subclass_of: Guanidines
Synonym: Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-
Synonym: GUANFACINE
Synonym: GuanFACINE
Synonym: Guanfacina
Synonym: Guanfacine (product)
Synonym: Guanfacine (substance)
Synonym: Guanfacine Extended-Release
Synonym: Guanfacine [Chemical/Ingredient]
Synonym: Guanfacinum
Synonym: Intuniv XR
Tree Number: T6.2.5.3.13
database_cross_reference: ATC:C02AC02
database_cross_reference: CHV:0000015178
database_cross_reference: DRUGBANK:DB01018
database_cross_reference: MEDCIN:340415
database_cross_reference: MMSL:6549
database_cross_reference: MMSL:d00717
database_cross_reference: MSH:D016316
database_cross_reference: MTHSPL:30OMY4G3MK
database_cross_reference: NCI:C61779
database_cross_reference: NCI_FDA:30OMY4G3MK
database_cross_reference: NDDF:004497
database_cross_reference: NDFRT:N0000007075
database_cross_reference: NDFRT:N0000147862
database_cross_reference: RXNORM:40114
database_cross_reference: SNOMEDCT_US:108553003
database_cross_reference: SNOMEDCT_US:372507007
database_cross_reference: USPMG:MTHU000779
database_cross_reference: VANDF:4019771

Gabexate
type: Class
subclass of: Guanidines
MCID: MC00043221
PMOID: PMO:00016016
Subclass_of: Guanidines
Synonym: Benzoic acid, 4-((6-((aminoiminomethyl)amino)-1-oxohexyl)oxy)-, ethyl ester
Synonym: Ethyl p-hydroxybenzoate 6-guanidinohexanoate
Synonym: GABEXATE
Synonym: Gabexate [Chemical/Ingredient]
Synonym: gabexate
Tree Number: T6.2.5.3.14
database_cross_reference: CHV:0000015509
database_cross_reference: DRUGBANK:DB12831
database_cross_reference: MSH:D016670
database_cross_reference: NCI:C76960
database_cross_reference: NCI_FDA:4V7M9137X9
database_cross_reference: NDFRT:N0000166586

Impromidine
type: Class
subclass of: Guanidines
MCID: MC00029136
PMOID: PMO:00016017
Subclass_of: Guanidines
Synonym: Guanidine, N-(3-(1H-imidazol-4-yl)propyl)-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-
Synonym: IMPROMIDINE
Synonym: Impromidine (product)
Synonym: Impromidine (substance)
Synonym: Impromidine [Chemical/Ingredient]
Tree Number: T6.2.5.3.15
database_cross_reference: MSH:D017446
database_cross_reference: NCI:C65902
database_cross_reference: NCI_FDA:931L4X5WMM
database_cross_reference: NDFRT:N0000167082
database_cross_reference: RCD:X797c
database_cross_reference: SNOMEDCT_US:255687007
database_cross_reference: SNOMEDCT_US:715271009

Guanidine
type: Class
subclass of: Guanidines
MCID: MC00005868
PMOID: PMO:00016018
Subclass_of: Guanidines
Synonym: Guanidines
Synonym: Guanidines [Chemical/Ingredient]
Synonym: guanidine
Tree Number: T6.2.5.3.16
database_cross_reference: CSP:1356-9885
database_cross_reference: MSH:D006146
database_cross_reference: MTH:U001969
database_cross_reference: NDFRT:N0000008038

3-Iodobenzylguanidine
type: Class
subclass of: Guanidines
MCID: MC00016818
PMOID: PMO:00016019
Subclass_of: Guanidines
Synonym: ((3-Iodophenyl)Methyl)Guanidine
Synonym: ((3-iodophenyl)methyl)guanidine
Synonym: 3 Iodobenzylguanidine
Synonym: 3-Iodobenzylguanidine [Chemical/Ingredient]
Synonym: 3-iodobenzylguanidine
Synonym: IOBENGUANE
Synonym: IODOBENZYLGUANIDINE 03
Synonym: Iobenguane
Synonym: M-Iodobenzylguanidine
Synonym: MIBG
Tree Number: T6.2.5.3.17
database_cross_reference: CHV:0000013361
database_cross_reference: DRUGBANK:DB06704
database_cross_reference: LNC:LP34991-7
database_cross_reference: MSH:D019797
database_cross_reference: NCI:C87757
database_cross_reference: NCI_FDA:35MRW7B4AD
database_cross_reference: NDFRT:N0000166590
database_cross_reference: NDFRT:N0000177925
database_cross_reference: PDQ:CDR0000038020
database_cross_reference: RXNORM:14448
database_cross_reference: SNOMEDCT_US:395786000
database_cross_reference: VANDF:4027963

Pinacidil
type: Class
subclass of: Guanidines
MCID: MC00035067
PMOID: PMO:00016020
Subclass_of: Guanidines
Synonym: Guanidine, N''-cyano-N-4-pyridinyl-N'-(1,2,2-trimethylpropylmonohydrate), (+-)-
Synonym: PINACIDIL
Synonym: Pinacidil [Chemical/Ingredient]
Synonym: pinacidil
Tree Number: T6.2.5.3.18
database_cross_reference: ATC:C02DG01
database_cross_reference: CSP:1356-9885
database_cross_reference: MSH:D020110
database_cross_reference: NCI:C66387
database_cross_reference: NCI_FDA:7B0ZZH8P2W
database_cross_reference: NDDF:003753
database_cross_reference: NDFRT:N0000166591
database_cross_reference: NDFRT:N0000171786
database_cross_reference: RXNORM:33717
database_cross_reference: VANDF:4025256

Zanamivir
type: Class
subclass of: Guanidines
subclass of: Pyrans
MCID: MC00069815
PMOID: PMO:00016021
Subclass_of: Guanidines
Subclass_of: Pyrans
Synonym: (2R,3R,4S)-3-(acetylamino)-4-Carbamimidamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
Synonym: 2,3-Didehydro-2,4-Dideoxy-4-Guanidino-N-Acetyl-D-Neuraminic Acid
Synonym: 2,3-Didehydro-2,4-Dideoxy-4-Guanidinyl-N-Acetylneuraminic Acid
Synonym: 4 Guanidino 2 Deoxy 2,3 Didehydro N Acetylneuraminic Acid
Synonym: 4 Guanidino Neu5Ac2en
Synonym: 4-Guanidino-2,4-Dideoxy-2,3-Didehydro-N-Acetylneuraminic Acid
Synonym: 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic Acid
Synonym: 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid
Synonym: 4-Guanidino-2-Deoxy-2,3-Didehydro-N-Acetylneuraminic Acid
Synonym: 4-Guanidino-Neu5Ac2en
Tree Number: T6.2.5.3.19
Tree Number: T6.3.5.17.11
database_cross_reference: ATC:J05AH01
database_cross_reference: CHV:0000021147
database_cross_reference: DRUGBANK:DB00558
database_cross_reference: LNC:LP101309-5
database_cross_reference: LNC:MTHU047708
database_cross_reference: MEDCIN:139772
database_cross_reference: MMSL:8261
database_cross_reference: MMSL:d04443
database_cross_reference: MSH:D053243
database_cross_reference: MTHSPL:L6O3XI777I
database_cross_reference: NCI:C47786
database_cross_reference: NCI_FDA:L6O3XI777I
database_cross_reference: NCI_NCI-GLOSS:CDR0000644781
database_cross_reference: NDDF:007857
database_cross_reference: NDFRT:N0000006453
database_cross_reference: NDFRT:N0000148618
database_cross_reference: RXNORM:69722
database_cross_reference: SNOMEDCT_US:116100000
database_cross_reference: SNOMEDCT_US:387010007
database_cross_reference: USPMG:MTHU000691
database_cross_reference: VANDF:4021167

Stilbamidines
type: Class
subclass of: Amidines
MCID: MC00012240
PMOID: PMO:00016022
Subclass_of: Amidines
Synonym: Stilbamidines [Chemical/Ingredient]
Synonym: stilbamidine
Tree Number: T6.2.5.4
database_cross_reference: CSP:2796-5763
database_cross_reference: MSH:D013266
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166581

Amines
type: Class
subclass of: Organic Chemicals
MCID: MC00000728
PMOID: PMO:00016023
Subclass_of: Organic Chemicals
Synonym: 217 AMINES
Synonym: AMINES
Synonym: Amine
Synonym: Amine (substance)
Synonym: Amine, NOS
Synonym: Amines [Chemical/Ingredient]
Synonym: NH2
Synonym: amine
Synonym: amines
Tree Number: T6.2.6
database_cross_reference: AOD:0000018449
database_cross_reference: CHV:0000001004
database_cross_reference: CSP:0118-9355
database_cross_reference: LCH:U000191
database_cross_reference: LCH_NW:sh85004479
database_cross_reference: MSH:D000588
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45564
database_cross_reference: NDFRT:N0000008168
database_cross_reference: PSY:02060
database_cross_reference: RCD:Xa7Nc
database_cross_reference: SNM:E-5700
database_cross_reference: SNM:U000139
database_cross_reference: SNMI:C-21700
database_cross_reference: SNOMEDCT_US:43201005

Allylamine
type: Class
subclass of: Amines
MCID: MC00000593
PMOID: PMO:00016024
Subclass_of: Amines
Synonym: 2-Propen-1-amine
Synonym: 3 Aminopropylene
Synonym: 3-Aminopropylene
Synonym: AMINOPROPYLENE 03
Synonym: Allylamine [Chemical/Ingredient]
Synonym: allylamine
Synonym: allylamines
Tree Number: T6.2.6.1
database_cross_reference: CHV:0000000920
database_cross_reference: CSP:0118-9355
database_cross_reference: MSH:D000499
database_cross_reference: NDFRT:N0000007522

Colesevelam Hydrochloride
type: Class
subclass of: Allylamine
MCID: MC00170097
PMOID: PMO:00016025
Subclass_of: Allylamine
Synonym: 1-Hexaminium, N,N,N-trimethyl-6-(2-propenylamino)-, Chloride, Polymer with (chloromethyl)oxirane, 2-propen-4-amine and N-2-propenyl-1-decanamine, Hydrochloride
Synonym: COLESEVELAM HYDROCHLORIDE
Synonym: Colesevelam HCl
Synonym: Colesevelam Hydrochloride [Chemical/Ingredient]
Synonym: Colesevelam hydrochloride
Synonym: Colesevelam hydrochloride (product)
Synonym: Colesevelam hydrochloride (substance)
Synonym: HCl, Colesevelam
Synonym: Hydrochloride, Colesevelam
Synonym: colesevelam HCl
Tree Number: T6.2.6.1.1
database_cross_reference: CHV:0000038496
database_cross_reference: MEDCIN:194754
database_cross_reference: MMSL:26906
database_cross_reference: MSH:D000069472
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:P4SG24WI5Q
database_cross_reference: NCI:C28937
database_cross_reference: NCI_FDA:P4SG24WI5Q
database_cross_reference: NDDF:008853
database_cross_reference: NDFRT:N0000180630
database_cross_reference: NDFRT:N0000191924
database_cross_reference: RXNORM:141625
database_cross_reference: SNOMEDCT_US:127965004
database_cross_reference: SNOMEDCT_US:397335007
database_cross_reference: USPMG:MTHU000993
database_cross_reference: VANDF:4029706

Aminopyridines
type: Class
subclass of: Amines
subclass of: Pyridines
MCID: MC00000774
PMOID: PMO:00016026
Subclass_of: Amines
Subclass_of: Pyridines
Synonym: Aminopyridines [Chemical/Ingredient]
Synonym: aminopyridine
Synonym: aminopyridines
Tree Number: T6.2.6.3
Tree Number: T6.3.5.20.4
database_cross_reference: CHV:0000001021
database_cross_reference: CSP:2511-0062
database_cross_reference: LCH:U000201
database_cross_reference: LCH_NW:sh85004507
database_cross_reference: MSH:D000631
database_cross_reference: MTH:U001683
database_cross_reference: NDFRT:N0000007862

Amrinone
type: Class
subclass of: Aminopyridines
MCID: MC00000824
PMOID: PMO:00016027
Subclass_of: Aminopyridines
Synonym: (3,4'-Bipyridin)-6(1H)-one, 5-amino-
Synonym: 5-Amino-(3,4'-bipyridine)-6(1H)-one
Synonym: AMRINONE
Synonym: Amrinon
Synonym: Amrinona
Synonym: Amrinone (product)
Synonym: Amrinone (substance)
Synonym: Amrinone [Chemical/Ingredient]
Synonym: Amrinonum
Synonym: INAMRINONE
Tree Number: T6.2.6.3.1
database_cross_reference: ATC:C01CE01
database_cross_reference: CHV:0000001062
database_cross_reference: DRUGBANK:DB01427
database_cross_reference: MEDCIN:40642
database_cross_reference: MMSL:d00172
database_cross_reference: MSH:D000676
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C61789
database_cross_reference: NCI_FDA:JUT23379TN
database_cross_reference: NDDF:006203
database_cross_reference: NDFRT:N0000005907
database_cross_reference: NDFRT:N0000147706
database_cross_reference: NDFRT:N0000148677
database_cross_reference: RXNORM:738
database_cross_reference: SNMI:C-80360
database_cross_reference: SNOMEDCT_US:373502005
database_cross_reference: SNOMEDCT_US:412411004
database_cross_reference: SNOMEDCT_US:412412006
database_cross_reference: SNOMEDCT_US:50163006
database_cross_reference: VANDF:4019612
database_cross_reference: VANDF:4021233

4-Aminopyridine
type: Class
subclass of: Aminopyridines
MCID: MC00000073
PMOID: PMO:00016029
Subclass_of: Aminopyridines
Synonym: 4 Aminopyridine
Synonym: 4 aminopyridine
Synonym: 4-AP
Synonym: 4-Aminopyridine (product)
Synonym: 4-Aminopyridine (substance)
Synonym: 4-Aminopyridine [Chemical/Ingredient]
Synonym: 4-Pyridinamine
Synonym: 4-Pyridylamine
Synonym: 4-aminopyridine
Synonym: AMINOPYRIDINE 04
Tree Number: T6.2.6.3.2
database_cross_reference: ATC:N07XX07
database_cross_reference: CHV:0000000512
database_cross_reference: DRUGBANK:DB06637
database_cross_reference: MEDCIN:307569
database_cross_reference: MMSL:26967
database_cross_reference: MMSL:NOCODE
database_cross_reference: MMSL:d07546
database_cross_reference: MSH:D015761
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:BH3B64OKL9
database_cross_reference: NCI:C76777
database_cross_reference: NCI_FDA:BH3B64OKL9
database_cross_reference: NDDF:006829
database_cross_reference: NDFRT:N0000167244
database_cross_reference: NDFRT:N0000176063
database_cross_reference: NDFRT:N0000176193
database_cross_reference: NDFRT:N0000180628
database_cross_reference: RXNORM:897018
database_cross_reference: SNMI:C-23419
database_cross_reference: SNOMEDCT_US:413355004
database_cross_reference: SNOMEDCT_US:80994002
database_cross_reference: USPMG:MTHU003018
database_cross_reference: VANDF:4025700
database_cross_reference: VANDF:4025705
database_cross_reference: VANDF:4029704

Butylscopolammonium Bromide
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00002059
PMOID: PMO:00016030
Subclass_of: Quaternary Ammonium Compounds
Synonym: 3-Oxa-9-azoniatricyclo(3.3.1.02,4)nonane, 9-butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-
Synonym: BUTYLSCOPOLAMINE BROMIDE
Synonym: Bromide, Butylscopolammonium
Synonym: Bromide, N-Butylscopolammonium
Synonym: Buscopan Sup 10mg
Synonym: Butylhyoscine
Synonym: Butylscopolamine
Synonym: Butylscopolamine Bromide
Synonym: Butylscopolamine bromide
Synonym: Butylscopolaminebromide
Tree Number: T6.2.6.4.1
database_cross_reference: CHV:0000002259
database_cross_reference: DRUGBANK:DB09300
database_cross_reference: MEDCIN:198517
database_cross_reference: MSH:D002086
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:0GH9JX37C8
database_cross_reference: NCI:C65277
database_cross_reference: NCI_FDA:0GH9JX37C8
database_cross_reference: NDDF:003459
database_cross_reference: NDFRT:N0000166994
database_cross_reference: RCD:a47..
database_cross_reference: RXNORM:1851
database_cross_reference: SNOMEDCT_US:317114008
database_cross_reference: SNOMEDCT_US:384974000
database_cross_reference: SNOMEDCT_US:395739004
database_cross_reference: SNOMEDCT_VET:5921000009102

Emepronium
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00004381
PMOID: PMO:00016031
Subclass_of: Quaternary Ammonium Compounds
Synonym: Benzenepropanaminium, N-ethyl-N,N,alpha-trimethyl-gamma-phenyl-
Synonym: Emepronium (product)
Synonym: Emepronium (substance)
Synonym: Emepronium [Chemical/Ingredient]
Synonym: emepronium
Tree Number: T6.2.27.1.12
Tree Number: T6.2.6.4.2
database_cross_reference: ATC:G04BD01
database_cross_reference: MSH:D004629
database_cross_reference: NDDF:005136
database_cross_reference: NDFRT:N0000166490
database_cross_reference: RXNORM:3816
database_cross_reference: SNOMEDCT_US:421158004
database_cross_reference: SNOMEDCT_US:421500009

Gallamine Triethiodide
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00005392
PMOID: PMO:00016032
Subclass_of: Quaternary Ammonium Compounds
Synonym: Ethanaminium, 2,2',2''-(1,2,3-benzenetriyltris(oxy))tris(N,N,N-triethyl)-, triiodide
Synonym: Flaxedil Inj 20mg/ml
Synonym: GALLAMINE TRIETHIODIDE
Synonym: Gallamin triethiodid
Synonym: Gallamine Triethiodide [Chemical/Ingredient]
Synonym: Gallamine Triethyl Iodide
Synonym: Gallamine triethiodide
Synonym: Gallamine triethiodide (product)
Synonym: Gallamine triethiodide (substance)
Synonym: Gallamine triethiodide [dup] (substance)
Tree Number: T6.2.27.1.13
Tree Number: T6.2.6.4.3
database_cross_reference: CSP:2268-3660
database_cross_reference: DRUGBANK:DB00483
database_cross_reference: MEDCIN:199119
database_cross_reference: MSH:D005703
database_cross_reference: NCI:C65798
database_cross_reference: NCI_FDA:Q3254X40X2
database_cross_reference: NDDF:005160
database_cross_reference: NDFRT:N0000006181
database_cross_reference: NDFRT:N0000147209
database_cross_reference: RCD:o63..
database_cross_reference: RXNORM:4639
database_cross_reference: SNM:E-7984
database_cross_reference: SNMI:C-68731
database_cross_reference: SNOMEDCT_US:17502009
database_cross_reference: SNOMEDCT_US:334036006
database_cross_reference: SNOMEDCT_US:387097006
database_cross_reference: VANDF:4018916

Glycopyrrolate
type: Class
subclass of: Quaternary Ammonium Compounds
subclass of: Pyrrolidines
MCID: MC00005769
PMOID: PMO:00016033
Subclass_of: Pyrrolidines
Subclass_of: Quaternary Ammonium Compounds
Synonym: GLYCOPYRROLATE
Synonym: Glycopyrrolate (product)
Synonym: Glycopyrrolate (substance)
Synonym: Glycopyrrolate [Chemical/Ingredient]
Synonym: glycopyrrolate
Synonym: glycopyrrolate (medication)
Tree Number: T6.2.27.1.14
Tree Number: T6.2.6.4.4
Tree Number: T6.3.5.22.3
database_cross_reference: CHV:0000005624
database_cross_reference: CSP:0156-8322
database_cross_reference: DRUGBANK:DB00986
database_cross_reference: MEDCIN:41078
database_cross_reference: MMSL:4794
database_cross_reference: MMSL:609
database_cross_reference: MMSL:d00992
database_cross_reference: MSH:D006024
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:V92SO9WP2I
database_cross_reference: NCI:C29078
database_cross_reference: NCI_FDA:V92SO9WP2I
database_cross_reference: NDDF:001737
database_cross_reference: NDFRT:N0000005922
database_cross_reference: NDFRT:N0000146747
database_cross_reference: RXNORM:4955
database_cross_reference: SNM:E-7566
database_cross_reference: SNMI:C-677B0
database_cross_reference: SNOMEDCT_US:22168005
database_cross_reference: SNOMEDCT_US:387122008
database_cross_reference: SNOMEDCT_US:395311003
database_cross_reference: USPMG:MTHU000709
database_cross_reference: VANDF:4018421

Hemicholinium 3
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00006047
PMOID: PMO:00016034
Subclass_of: Quaternary Ammonium Compounds
Synonym: Hemicholinium
Synonym: Hemicholinium 3 [Chemical/Ingredient]
Synonym: Morpholinium, 2,2'-(1,1'-biphenyl)-4,4'-diylbis(2-hydroxy-4,4-dimethyl)-, dibromide
Synonym: hemicholinium
Synonym: hemicholinium 3
Tree Number: T6.2.27.1.15
Tree Number: T6.2.6.4.5
database_cross_reference: CHV:0000005968
database_cross_reference: MSH:D006426
database_cross_reference: NDFRT:N0000166494

Lissamine Green Dyes
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00007633
PMOID: PMO:00016035
Subclass_of: Quaternary Ammonium Compounds
Synonym: Dyes, Lissamine Green
Synonym: Green Dyes, Lissamine
Synonym: Lissamine Green Dyes [Chemical/Ingredient]
Tree Number: T6.2.27.1.16
Tree Number: T6.2.6.4.6
database_cross_reference: MSH:D008086
database_cross_reference: NDFRT:N0000011170

Bis-Trimethylammonium Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00539798
PMOID: PMO:00016036
Subclass_of: Quaternary Ammonium Compounds
Synonym: Bis Trimethyl Ammonium Compounds
Synonym: Bis Trimethylammonium Compounds
Synonym: Bis-Trimethyl-Ammonium Compounds
Synonym: Bis-Trimethylammonium Compounds [Chemical/Ingredient]
Tree Number: T6.2.27.1.19
Tree Number: T6.2.6.4.7
database_cross_reference: MSH:D008725
database_cross_reference: NDFRT:N0000166491

Oxyphenonium
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00009592
PMOID: PMO:00016040
Subclass_of: Quaternary Ammonium Compounds
Synonym: 2-((Cyclohexylhydroxyphenylacetyl)oxy)-N,N-diethyl-N-methylethanaminium
Synonym: A-Spasm
Synonym: Antispasmin
Synonym: Antrenex
Synonym: Antrenyl
Synonym: Atrenex
Synonym: Ethanaminium, 2-((cyclohexylhydroxyphenylacetyl)oxy)-N,N-diethyl-N-methyl-
Synonym: Metacin
Synonym: Methacin
Synonym: OXYPHENONIUM
Tree Number: T6.2.27.1.22
Tree Number: T6.2.6.4.8
database_cross_reference: ATC:A03AB03
database_cross_reference: CHV:0000009162
database_cross_reference: DRUGBANK:DB00219
database_cross_reference: MSH:D010115
database_cross_reference: NCI:C78076
database_cross_reference: NCI_FDA:D2G5508Y7I
database_cross_reference: NDDF:004694
database_cross_reference: NDFRT:N0000006438
database_cross_reference: NDFRT:N0000147958
database_cross_reference: RXNORM:7818
database_cross_reference: SNM:E-7581
database_cross_reference: SNMI:C-67365
database_cross_reference: SNOMEDCT_US:69506001
database_cross_reference: VANDF:4019873

Propantheline
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00010707
PMOID: PMO:00016041
Subclass_of: Quaternary Ammonium Compounds
Synonym: 2-Propanaminium, N-methyl-N-(1-methylethyl)-N-(2-((9H-xanthen-9-ylcarbonyl)oxy)ethyl)-
Synonym: Ercoril
Synonym: Methaphyllin
Synonym: PROPANTHELINE
Synonym: Pro-banthine Tablets 7.5 mg
Synonym: Prokind
Synonym: Propanline
Synonym: Propanthel Tab 15mg
Synonym: Propantheline (product)
Synonym: Propantheline (substance)
Tree Number: T6.2.27.1.23
Tree Number: T6.2.6.4.9
database_cross_reference: ATC:A03AB05
database_cross_reference: CHV:0000010188
database_cross_reference: DRUGBANK:DB00782
database_cross_reference: MMSL:d00359
database_cross_reference: MSH:D011413
database_cross_reference: MTHSPL:1306V2B0Q8
database_cross_reference: NCI:C78077
database_cross_reference: NCI_FDA:1306V2B0Q8
database_cross_reference: NDDF:004693
database_cross_reference: NDFRT:N0000006715
database_cross_reference: NDFRT:N0000147997
database_cross_reference: RCD:x01Dk
database_cross_reference: RXNORM:8761
database_cross_reference: SNM:E-7591
database_cross_reference: SNMI:C-67830
database_cross_reference: SNOMEDCT_US:36642006
database_cross_reference: SNOMEDCT_US:372721007
database_cross_reference: VANDF:4019912

Tetraethylammonium Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00012651
PMOID: PMO:00016042
Subclass_of: Quaternary Ammonium Compounds
Synonym: Compounds, Tetraethylammonium
Synonym: TETRAETHYLAMMONIUM CPDS
Synonym: Tetraethylammonium Compounds [Chemical/Ingredient]
Synonym: Tetrylammonium
Synonym: tetraethylammonium compound
Synonym: tetramethylammonium compound
Tree Number: T6.2.27.1.24
Tree Number: T6.2.6.4.10
database_cross_reference: CSP:0156-8322
database_cross_reference: CSP:0157-3911
database_cross_reference: MSH:D013757
database_cross_reference: NDFRT:N0000166495

Toxiferine
type: Class
subclass of: Quaternary Ammonium Compounds
subclass of: Benzylisoquinolines
MCID: MC00012949
PMOID: PMO:00016044
Subclass_of: Benzylisoquinolines
Subclass_of: Quaternary Ammonium Compounds
Synonym: Toxiferine I, 2,2',16,16'-tetradehydro-16,16',17,17'-tetrahydro-
Synonym: Toxiferine [Chemical/Ingredient]
Synonym: toxiferine
Tree Number: T6.2.27.1.25
Tree Number: T6.2.6.4.11
Tree Number: T6.3.3.26.5
database_cross_reference: CHV:0000012406
database_cross_reference: MSH:D014117
database_cross_reference: NDFRT:N0000166957

Tubocurarine
type: Class
subclass of: Quaternary Ammonium Compounds
subclass of: Benzylisoquinolines
MCID: MC00013219
PMOID: PMO:00016046
Subclass_of: Benzylisoquinolines
Subclass_of: Quaternary Ammonium Compounds
Synonym: (+)-tubocurarine
Synonym: 7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium
Synonym: TUBOCURARINE
Synonym: Tubarine
Synonym: Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-
Synonym: Tubocurare
Synonym: Tubocurarin
Synonym: Tubocurarine (product)
Synonym: Tubocurarine (substance)
Synonym: Tubocurarine Chloride Inj 3mg/ml USP
Tree Number: T6.2.27.1.26
Tree Number: T6.2.6.4.12
Tree Number: T6.3.3.26.6
database_cross_reference: AOD:0000020510
database_cross_reference: ATC:M03AA02
database_cross_reference: CHV:0000012652
database_cross_reference: CSP:2530-4485
database_cross_reference: DRUGBANK:DB01199
database_cross_reference: LCH:U004811
database_cross_reference: LCH_NW:sh85138466
database_cross_reference: MMSL:d00949
database_cross_reference: MSH:D014403
database_cross_reference: MTHSPL:W9YXS298BM
database_cross_reference: NCI:C47777
database_cross_reference: NDDF:002399
database_cross_reference: NDFRT:N0000006051
database_cross_reference: NDFRT:N0000148050
database_cross_reference: PSY:54420
database_cross_reference: RCD:x01G0
database_cross_reference: RXNORM:10917
database_cross_reference: SNM:E-7994
database_cross_reference: SNMI:C-68760
database_cross_reference: SNOMEDCT_US:373486008
database_cross_reference: SNOMEDCT_US:37803001
database_cross_reference: VANDF:4019965

Trimethyl Ammonium Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00540235
PMOID: PMO:00016047
Subclass_of: Quaternary Ammonium Compounds
Synonym: Ammonium Compounds, Trimethyl
Synonym: TRIMETHYL AMMONIUM CPDS
Synonym: Trimethyl Ammonium Compounds [Chemical/Ingredient]
Tree Number: T6.2.6.4.13
database_cross_reference: MSH:D050337
database_cross_reference: NDFRT:N0000166501

Betaine
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00001692
PMOID: PMO:00016048
Subclass_of: Quaternary Ammonium Compounds
Synonym: 2-(Trimethylammonio)Acetate
Synonym: 2-N,N,N-trimethylammonio acetate
Synonym: 2-trimethylammonioacetate
Synonym: ATONO2 Oxygen Baby
Synonym: Acididyn Tab
Synonym: BETAINE
Synonym: Bemosin Tab
Synonym: Betacol
Synonym: Betaine (substance)
Synonym: Betaine HCl Tab 500mg
Tree Number: T6.2.27.1.5
database_cross_reference: ATC:A16AA06
database_cross_reference: CHV:0000001833
database_cross_reference: CSP:0156-9564
database_cross_reference: DRUGBANK:DB06756
database_cross_reference: LCH_NW:sh2005007337
database_cross_reference: MEDCIN:258267
database_cross_reference: MMSL:11810
database_cross_reference: MMSL:d04875
database_cross_reference: MSH:D001622
database_cross_reference: MTHSPL:3SCV180C9W
database_cross_reference: NCI:C81038
database_cross_reference: NCI_FDA:3SCV180C9W
database_cross_reference: NDDF:004543
database_cross_reference: NDDF:006281
database_cross_reference: NDFRT:N0000006734
database_cross_reference: NDFRT:N0000147725
database_cross_reference: RXNORM:1512
database_cross_reference: SNM:E-8709
database_cross_reference: SNMI:C-85310
database_cross_reference: SNOMEDCT_US:413645006
database_cross_reference: SNOMEDCT_US:43356007
database_cross_reference: USPMG:MTHU001174
database_cross_reference: VANDF:4019632

Bethanechol Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00001701
PMOID: PMO:00016049
Subclass_of: Quaternary Ammonium Compounds
Synonym: BETHANECHOL CPDS
Synonym: Bethanechol Compounds [Chemical/Ingredient]
Synonym: Compounds, Bethanechol
Tree Number: T6.2.27.1.6
database_cross_reference: MSH:D001626
database_cross_reference: NDFRT:N0000007678

Cetrimonium Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00002568
PMOID: PMO:00016054
Subclass_of: Quaternary Ammonium Compounds
Synonym: CETRIMONIUM CPDS
Synonym: CETYLTRIMETHYLAMMONIUM CPDS
Synonym: Cetrimonium Compounds [Chemical/Ingredient]
Synonym: Cetyltrimethylammonium Compounds
Synonym: Compounds, Cetrimonium
Synonym: Compounds, Cetyltrimethylammonium
Tree Number: T6.2.27.1.7
database_cross_reference: MSH:D002593
database_cross_reference: NDFRT:N0000008047

Chlorisondamine
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00002651
PMOID: PMO:00016055
Subclass_of: Quaternary Ammonium Compounds
Synonym: 1H-Isoindolium, 4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-(2-(trimethylammonio)ethyl)-, dichloride
Synonym: CHLORISONDAMINE
Synonym: Chlorisondamine (substance)
Synonym: Chlorisondamine [Chemical/Ingredient]
Tree Number: T6.2.27.1.8
database_cross_reference: MSH:D002714
database_cross_reference: NCI:C83619
database_cross_reference: NCI_FDA:JD3M24F66I
database_cross_reference: NDFRT:N0000166970
database_cross_reference: PSY:08960
database_cross_reference: SNM:E-7632
database_cross_reference: SNMI:C-81270
database_cross_reference: SNOMEDCT_US:26992003

Chlormequat
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00002653
PMOID: PMO:00016056
Subclass_of: Quaternary Ammonium Compounds
Synonym: Chlormequat [Chemical/Ingredient]
Synonym: Ethanaminium, 2-chloro-N,N,N-trimethyl-
Tree Number: T6.2.27.1.9
database_cross_reference: MSH:D002716
database_cross_reference: NDFRT:N0000166502

Thiocholine
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00012728
PMOID: PMO:00016063
Subclass_of: Sulfhydryl Compounds
Synonym: Ethanaminium, 2-mercapto-N,N,N-trimethyl-
Synonym: Thiocholine [Chemical/Ingredient]
Tree Number: T6.2.32.6.9
database_cross_reference: MSH:D013860
database_cross_reference: NDFRT:N0000166504

Methacholine Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00008154
PMOID: PMO:00016066
Subclass_of: Quaternary Ammonium Compounds
Synonym: Compounds, Methacholine
Synonym: METHACHOLINE CPDS
Synonym: Methacholine Compounds [Chemical/Ingredient]
Tree Number: T6.2.27.1.18
database_cross_reference: MSH:D008688
database_cross_reference: NDFRT:N0000007995

Muscarine
type: Class
subclass of: Quaternary Ammonium Compounds
subclass of: Alkaloids
MCID: MC00008481
PMOID: PMO:00016068
Subclass_of: Alkaloids
Subclass_of: Quaternary Ammonium Compounds
Synonym: 2-Furanmethanaminium, tetrahydro-4-hydroxy-N,N,N,5-tetramethyl-, (2S-(2alpha,4beta,5alpha))-
Synonym: Muscarine (substance)
Synonym: Muscarine [Chemical/Ingredient]
Synonym: muscarine
Tree Number: T6.2.27.1.20
Tree Number: T6.3.3.13
database_cross_reference: CHV:0000008343
database_cross_reference: CSP:0092-8747
database_cross_reference: LCH:U003059
database_cross_reference: LCH_NW:sh85088669
database_cross_reference: MSH:D009116
database_cross_reference: NDDF:001692
database_cross_reference: NDFRT:N0000166905
database_cross_reference: RCD:Xa3di
database_cross_reference: SNM:E-6873
database_cross_reference: SNMI:C-30901
database_cross_reference: SNOMEDCT_US:59755005

Phenylammonium Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00540236
PMOID: PMO:00016069
Subclass_of: Quaternary Ammonium Compounds
Synonym: Phenylammonium Compounds [Chemical/Ingredient]
Tree Number: T6.2.6.4.14
database_cross_reference: MSH:D050338
database_cross_reference: NDFRT:N0000166497

Edrophonium
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00004308
PMOID: PMO:00016070
Subclass_of: Quaternary Ammonium Compounds
Synonym: (3-Hydroxyphenyl)dimethylethylammonium
Synonym: 3-hydroxy-N,N-dimethyl-N-ethylanilinium
Synonym: Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-
Synonym: EDR
Synonym: EDROPHONIUM
Synonym: Edrophonium (product)
Synonym: Edrophonium (substance)
Synonym: Edrophonium Ion
Synonym: Edrophonium [Chemical/Ingredient]
Synonym: Edroponium
Tree Number: T6.2.27.1.11
database_cross_reference: CHV:0000004271
database_cross_reference: DRUGBANK:DB01010
database_cross_reference: MMSL:d00220
database_cross_reference: MSH:D004491
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:70FP3JLY7N
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C76137
database_cross_reference: NCI_FDA:70FP3JLY7N
database_cross_reference: NDDF:004688
database_cross_reference: NDFRT:N0000006186
database_cross_reference: NDFRT:N0000147833
database_cross_reference: RCD:x01DJ
database_cross_reference: RXNORM:3752
database_cross_reference: SNMI:C-67160
database_cross_reference: SNOMEDCT_US:373342004
database_cross_reference: SNOMEDCT_US:46913003
database_cross_reference: VANDF:4019741

(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00442176
PMOID: PMO:00016071
Subclass_of: Quaternary Ammonium Compounds
Synonym: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride [Chemical/Ingredient]
Synonym: 2-Butyn-1-aminium, 4-((((3-chlorophenyl)amino)carbonyl)oxy)-N,N,N-trimethyl-, chloride
Synonym: CHLOROPHENYLCARBAMOYLOXY 2 BUTYNYL TRIMETHYLAMMONIUM CHLORIDE 4 M
Tree Number: T6.2.27.1.17
database_cross_reference: MSH:D008455
database_cross_reference: NDFRT:N0000166498

Neostigmine
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00008752
PMOID: PMO:00016072
Subclass_of: Quaternary Ammonium Compounds
Synonym: (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate
Synonym: 3-Trimethylammoniumphenyl N,N-dimethylcarbamate
Synonym: Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-
Synonym: Eustigmin
Synonym: Eustigmine
Synonym: NEOSTIGMINE
Synonym: Neostigmine (product)
Synonym: Neostigmine (substance)
Synonym: Neostigmine Methylsulfate Inj 0.5mg/ml USP
Synonym: Neostigmine Methylsulfate Inj 1mg/ml USP
Tree Number: T6.2.27.1.21
database_cross_reference: ATC:N07AA01
database_cross_reference: ATC:S01EB06
database_cross_reference: CHV:0000008572
database_cross_reference: CSP:2268-8823
database_cross_reference: DRUGBANK:DB01400
database_cross_reference: LNC:LP19164-0
database_cross_reference: LNC:MTHU007457
database_cross_reference: MMSL:d00313
database_cross_reference: MSH:D009388
database_cross_reference: MTHSPL:3982TWQ96G
database_cross_reference: NCI:C75024
database_cross_reference: NCI_FDA:3982TWQ96G
database_cross_reference: NDDF:001703
database_cross_reference: NDFRT:N0000006537
database_cross_reference: NDFRT:N0000147942
database_cross_reference: PSY:33390
database_cross_reference: PSY:41130
database_cross_reference: RCD:j73..
database_cross_reference: RCD:x02MR
database_cross_reference: RXNORM:7315
database_cross_reference: SNM:E-7531
database_cross_reference: SNMI:C-67130
database_cross_reference: SNOMEDCT_US:330093009
database_cross_reference: SNOMEDCT_US:373346001
database_cross_reference: SNOMEDCT_US:80024007
database_cross_reference: VANDF:4019856

Benzylammonium Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00540237
PMOID: PMO:00016073
Subclass_of: Quaternary Ammonium Compounds
Synonym: Ammonium Compounds, Benzyl
Synonym: Ammonium Compounds, Phenylmethyl
Synonym: BENZENEMETHANAMINIUM CPDS
Synonym: BENZYL AMMONIUM CPDS
Synonym: BENZYLAMMONIUM CPDS
Synonym: Benzenemethanaminium Compounds
Synonym: Benzyl Ammonium Compounds
Synonym: Benzylammonium Compounds [Chemical/Ingredient]
Synonym: PHENYLMETHYL AMMONIUM CPDS
Synonym: Phenylmethyl Ammonium Compounds
Tree Number: T6.2.6.4.15
database_cross_reference: MSH:D050339
database_cross_reference: NDFRT:N0000166499

Ambenonium Chloride
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00000697
PMOID: PMO:00016074
Subclass_of: Quaternary Ammonium Compounds
Synonym: (Oxalylbis(iminoethylene))bis((o-chlorobenzyl)diethyl-ammonium), Dichloride
Synonym: AMBENONIUM CHLORIDE
Synonym: Ambenonium Chloride [Chemical/Ingredient]
Synonym: Ambenonium chloride
Synonym: Ambenonium chloride (substance)
Synonym: Ambestigmine chloride
Synonym: Benzenemethanaminium, N,N'-((1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl))bis(2-chloro-N,N-diethyl)-, dichloride
Synonym: Chloride, Ambenonium
Synonym: Misuran
Synonym: N,N'-((1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl))bis(2-chloro-N,N-diethyl-benzenemethanaminium), Dichloride
Tree Number: T6.2.27.1.1
database_cross_reference: MEDCIN:199125
database_cross_reference: MMSL:4162
database_cross_reference: MSH:D000549
database_cross_reference: NCI:C47388
database_cross_reference: NCI_FDA:51FOB87G3I
database_cross_reference: NDDF:001706
database_cross_reference: NDFRT:N0000006673
database_cross_reference: NDFRT:N0000146577
database_cross_reference: RXNORM:624
database_cross_reference: SNM:E-7542
database_cross_reference: SNMI:C-67111
database_cross_reference: SNOMEDCT_US:46887006
database_cross_reference: USPMG:MTHU000724
database_cross_reference: VANDF:4018246

Benzalkonium Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00001562
PMOID: PMO:00016075
Subclass_of: Quaternary Ammonium Compounds
Synonym: BENZALKONIUM CPDS
Synonym: Benzalkonium Compounds [Chemical/Ingredient]
Synonym: Compounds, Benzalkonium
Tree Number: T6.2.27.1.2
database_cross_reference: MSH:D001548
database_cross_reference: NDFRT:N0000005837

Benzethonium
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00001572
PMOID: PMO:00016076
Subclass_of: Quaternary Ammonium Compounds
Synonym: BENZETHONIUM
Synonym: Benzenemethanaminium, N,N-Dimethyl-N-(2-(2-(4-(1,1,3,3-Tetramethylbutyl)Phenoxy)Ethoxy)Ethyl)
Synonym: Benzenemethanaminium, N,N-dimethyl-N-(2-(2-(4-(1,1,3,3-tetramethylbutyl)phenoxy)ethoxy)ethyl)-, chloride
Synonym: Benzethonium (product)
Synonym: Benzethonium (substance)
Synonym: Benzethonium [Chemical/Ingredient]
Synonym: benzethonium
Tree Number: T6.2.27.1.3
database_cross_reference: ATC:R02AA09
database_cross_reference: DRUGBANK:DB11125
database_cross_reference: MSH:D001558
database_cross_reference: MTHSPL:1VU15B70BP
database_cross_reference: NCI:C87255
database_cross_reference: NCI_FDA:1VU15B70BP
database_cross_reference: NDFRT:N0000005872
database_cross_reference: RXNORM:1390
database_cross_reference: SNM:E-7104
database_cross_reference: SNMI:C-90280
database_cross_reference: SNOMEDCT_US:34929006
database_cross_reference: SNOMEDCT_US:373482005

Bephenium Compounds
type: Class
subclass of: Quaternary Ammonium Compounds
MCID: MC00001616
PMOID: PMO:00016077
Subclass_of: Quaternary Ammonium Compounds
Synonym: BEPHENIUM CPDS
Synonym: Bephenium Compounds [Chemical/Ingredient]
Synonym: Bephenium Derivatives
Synonym: Compounds, Bephenium
Synonym: Derivatives, Bephenium
Tree Number: T6.2.27.1.4
database_cross_reference: MSH:D001598
database_cross_reference: NDFRT:N0000166500

Betalains
type: Class
subclass of: Quaternary Ammonium Compounds
subclass of: Alkaloids
subclass of: Piperidines
MCID: MC00184456
PMOID: PMO:00016080
Subclass_of: Alkaloids
Subclass_of: Piperidines
Subclass_of: Quaternary Ammonium Compounds
Synonym: Betalains [Chemical/Ingredient]
Tree Number: T6.2.27.1.27
Tree Number: T6.2.6.4.16
Tree Number: T6.3.3.28
Tree Number: T6.3.5.16.33
database_cross_reference: MSH:D050858
database_cross_reference: NDFRT:N0000170248

Betacyanins
type: Class
subclass of: Betalains
MCID: MC00541123
PMOID: PMO:00016081
Subclass_of: Betalains
Synonym: Betacyanins [Chemical/Ingredient]
Tree Number: T6.3.3.28.1
database_cross_reference: MSH:D050859
database_cross_reference: NDFRT:N0000170249

Betaxanthins
type: Class
subclass of: Betalains
MCID: MC00541126
PMOID: PMO:00016082
Subclass_of: Betalains
Synonym: Betaxanthins [Chemical/Ingredient]
Tree Number: T6.3.3.28.2
database_cross_reference: MSH:D050860
database_cross_reference: NDFRT:N0000167213

Aniline Compounds
type: Class
subclass of: Amines
MCID: MC00000941
PMOID: PMO:00016083
Subclass_of: Amines
Synonym: ANILINE CPDS
Synonym: Aniline Compounds [Chemical/Ingredient]
Synonym: Anilines
Synonym: Compounds, Aniline
Synonym: Phenylamines
Synonym: aniline compounds
Tree Number: T6.2.6.5
database_cross_reference: AOD:0000020200
database_cross_reference: MSH:D000814
database_cross_reference: NDFRT:N0000007516

Aminophenols
type: Class
subclass of: Aniline Compounds
MCID: MC00000769
PMOID: PMO:00016084
Subclass_of: Aniline Compounds
Synonym: Aminophenols [Chemical/Ingredient]
Synonym: Hydroxyanilines
Tree Number: T6.2.6.5.1
database_cross_reference: MSH:D000627
database_cross_reference: NDFRT:N0000166619

Phenetidine
type: Class
subclass of: Ethyl Ethers
subclass of: Phenyl Ethers
MCID: MC00010010
PMOID: PMO:00016085
Subclass_of: Ethyl Ethers
Subclass_of: Phenyl Ethers
Synonym: Aminophenetole
Synonym: Benzenamine, 4-ethoxy-
Synonym: Ethoxyaniline
Synonym: Phenetidine [Chemical/Ingredient]
Tree Number: T6.2.14.4.4
Tree Number: T6.2.14.7.3
database_cross_reference: MSH:D010628
database_cross_reference: NDFRT:N0000166637

Anilino Naphthalenesulfonates
type: Class
subclass of: Aniline Compounds
MCID: MC00000943
PMOID: PMO:00016086
Subclass_of: Aniline Compounds
Synonym: Anilino Naphthalenesulfonates [Chemical/Ingredient]
Synonym: Naphthalenesulfonates, Anilino
Tree Number: T6.2.6.5.3
database_cross_reference: MSH:D000817
database_cross_reference: NDFRT:N0000167384

Benzophenoneidum
type: Class
subclass of: Aniline Compounds
MCID: MC00001590
PMOID: PMO:00016087
Subclass_of: Aniline Compounds
Synonym: Benzenamine, 4,4'-carbonimidoylbis(N,N-dimethyl)-, monohydrochloride
Synonym: Benzophenoneidum [Chemical/Ingredient]
Tree Number: T6.2.6.5.4
database_cross_reference: MSH:D001576
database_cross_reference: NDFRT:N0000166538

Bromhexine
type: Class
subclass of: Aniline Compounds
subclass of: Cyclohexylamines
MCID: MC00001953
PMOID: PMO:00016088
Subclass_of: Aniline Compounds
Subclass_of: Cyclohexylamines
Synonym: 3,5-Dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine
Synonym: Amiorel
Synonym: BROMHEXINE
Synonym: Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-
Synonym: Bisolmed
Synonym: Bisolvon Chesty
Synonym: Bromexina
Synonym: Bromhexina
Synonym: Bromhexine (substance)
Synonym: Bromhexine [Chemical/Ingredient]
Tree Number: T6.2.6.11.1
Tree Number: T6.2.6.5.5
database_cross_reference: ATC:R05CB02
database_cross_reference: CHV:0000002171
database_cross_reference: DRUGBANK:DB09019
database_cross_reference: MSH:D001964
database_cross_reference: MTHSPL:Q1J152VB1P
database_cross_reference: NDDF:003678
database_cross_reference: NDFRT:N0000166541
database_cross_reference: RXNORM:1753
database_cross_reference: SNOMEDCT_US:708561003

Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide
type: Class
subclass of: Aniline Compounds
MCID: MC00474715
PMOID: PMO:00016090
Subclass_of: Aniline Compounds
Synonym: BENZENAMINIUM 4 4 3 OXO 1 5 PENTANEDIYL BIS N N DIMETHYL N 2 PROPENYL DIBROMIDE
Synonym: Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl)-, dibromide
Synonym: Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide [Chemical/Ingredient]
Tree Number: T6.2.6.5.6
database_cross_reference: MSH:D002093
database_cross_reference: NDFRT:N0000166533

p-Dimethylaminoazobenzene
type: Class
subclass of: Aniline Compounds
MCID: MC00003964
PMOID: PMO:00016091
Subclass_of: Aniline Compounds
Synonym: 4 Dimethylaminoazobenzene
Synonym: 4-Dimethylaminoazo benzene
Synonym: 4-Dimethylaminoazobenzene
Synonym: 4-Dimethylaminoazobenzene (substance)
Synonym: Benzenamine, N,N-dimethyl-4-(phenylazo)-
Synonym: Butter Yellow
Synonym: Butter yellow
Synonym: C.I. 11020
Synonym: C.I. Solvent Yellow 2
Synonym: DAB
Tree Number: T6.2.6.5.7
database_cross_reference: MSH:D004124
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44324
database_cross_reference: NCI_DCP:01336
database_cross_reference: NCI_FDA:A49L8E13FD
database_cross_reference: NDFRT:N0000166539
database_cross_reference: SNM:E-6945
database_cross_reference: SNMI:C-29031
database_cross_reference: SNOMEDCT_US:49952006

Diphenylamine
type: Class
subclass of: Aniline Compounds
MCID: MC00004008
PMOID: PMO:00016093
Subclass_of: Aniline Compounds
Synonym: Benzenamine, N-phenyl-
Synonym: DIPHENYLAMINE
Synonym: Diphenylamine (substance)
Synonym: Diphenylamine [Chemical/Ingredient]
Synonym: diphenylamine
Tree Number: T6.2.6.5.8
database_cross_reference: CHV:0000003984
database_cross_reference: LCH_NW:sh91004706
database_cross_reference: MSH:D004159
database_cross_reference: MTHSPL:9N3CBB0BIQ
database_cross_reference: NDFRT:N0000166535
database_cross_reference: RXNORM:1363044
database_cross_reference: SNM:E-5705
database_cross_reference: SNMI:C-21721
database_cross_reference: SNOMEDCT_US:12233003

Gentian Violet
type: Class
subclass of: Aniline Compounds
MCID: MC00105710
PMOID: PMO:00016094
Subclass_of: Aniline Compounds
Synonym: Crystal Violet
Synonym: Crystal violet carbocation
Synonym: Crystal violet ion(1)
Synonym: Crystal violet(1+)
Synonym: De LA Cruz Gentian Violet
Synonym: Gentian Violet 2%
Synonym: Gentian Violet Topical Solution
Synonym: Gentian violet carbocation
Synonym: Gentian violet cation
Synonym: Gentian violet(1+)
Tree Number: T6.2.6.5.9
database_cross_reference: ATC:D01AE02
database_cross_reference: ATC:G01AX09
database_cross_reference: DRUGBANK:DB00406
database_cross_reference: SNM:E-7132
database_cross_reference: SNMI:C-902C6
database_cross_reference: SNOMEDCT_US:61306004

Kynuramine
type: Class
subclass of: Aniline Compounds
subclass of: Propiophenones
MCID: MC00007294
PMOID: PMO:00016095
Subclass_of: Aniline Compounds
Subclass_of: Propiophenones
Synonym: 1-Propanone, 3-amino-1-(2-aminophenyl)-
Synonym: 2,3 Diaminopropiophenone
Synonym: 2,3-Diaminopropiophenone
Synonym: Diaminopropiophenone
Synonym: Kynuramine [Chemical/Ingredient]
Tree Number: T6.2.20.14.2
Tree Number: T6.2.6.5.10
database_cross_reference: MSH:D007735
database_cross_reference: NDFRT:N0000166789

Methyl Green
type: Class
subclass of: Aniline Compounds
MCID: MC00008205
PMOID: PMO:00016096
Subclass_of: Aniline Compounds
Synonym: Basic blue 20
Synonym: Benzenaminium, 4-((4-(dimethylamino)phenyl)(4-(dimethyliminio)-2,5-cyclohexadien-1-ylidene)methyl)-N,N,N-trimethyl-, dichloride
Synonym: Green, Light
Synonym: Green, Methyl
Synonym: Light Green
Synonym: Methyl Green [Chemical/Ingredient]
Synonym: Methyl green
Synonym: Methyl green (substance)
Synonym: Methyl green stain
Synonym: Methyl green stain (substance)
Tree Number: T6.2.6.5.11
database_cross_reference: CHV:0000008050
database_cross_reference: MSH:D008739
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166537
database_cross_reference: SNMI:C-22896
database_cross_reference: SNOMEDCT_US:22021002

Methylenebis(chloroaniline)
type: Class
subclass of: Aniline Compounds
MCID: MC00008222
PMOID: PMO:00016097
Subclass_of: Aniline Compounds
Synonym: 2,2'-Dichloro-4,4'-methylenedianiline
Synonym: 3,3'-Dichloro-4,4'-Diaminodiphenylmethane
Synonym: 4,4'-METHYLENEBIS(2-CHLOROANILINE)
Synonym: 4,4'-Methylene(bis)chloroaniline
Synonym: 4,4'-Methylenebis(2-chloroaniline)
Synonym: 4,4'-Methylenebis(2-chlorobenzeneamine)
Synonym: 4,4-Methylenebis,2-Chloroaniline
Synonym: Benzenamine, 4,4'-methylenebis(2-chloro)-
Synonym: DACPM
Synonym: MBOCA
Tree Number: T6.2.6.5.12
database_cross_reference: CHV:0000008057
database_cross_reference: MSH:D008753
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44319
database_cross_reference: NCI_FDA:3L2W5VTT2A
database_cross_reference: NDFRT:N0000166536

p-Aminoazobenzene
type: Class
subclass of: Aniline Compounds
subclass of: Azo Compounds
MCID: MC00009605
PMOID: PMO:00016098
Subclass_of: Aniline Compounds
Subclass_of: Azo Compounds
Synonym: 4-(Phenylazo)benzenamine
Synonym: 4-(Phenyldiazenyl)aniline
Synonym: 4-Aminoazobenzene
Synonym: 4-Aminoazobenzene (product)
Synonym: 4-Aminoazobenzene (substance)
Synonym: AMINOAZOBENZENE P
Synonym: Aniline Yellow
Synonym: Benzenamine, 4-(phenylazo)-
Synonym: p Aminoazobenzene
Synonym: p-Aminoazobenzene [Chemical/Ingredient]
Tree Number: T6.2.10.12
Tree Number: T6.2.6.5.13
database_cross_reference: MSH:D010128
database_cross_reference: NDFRT:N0000166314
database_cross_reference: RCD:X79KO
database_cross_reference: SNOMEDCT_US:256089001
database_cross_reference: SNOMEDCT_US:411434006

Phenylenediamines
type: Class
subclass of: Aniline Compounds
MCID: MC00010043
PMOID: PMO:00016099
Subclass_of: Aniline Compounds
Synonym: PHENYLENEDIAMINE
Synonym: Phenylenediamines [Chemical/Ingredient]
Synonym: phenylenediamine
Synonym: phenylenediamines
Tree Number: T6.2.6.5.14
database_cross_reference: AOD:0000020202
database_cross_reference: CHV:0000009614
database_cross_reference: CSP:2268-8331
database_cross_reference: LCH_NW:sh97002862
database_cross_reference: MSH:D010655
database_cross_reference: NDFRT:N0000023078
database_cross_reference: NDFRT:N0000166543
database_cross_reference: VANDF:4021505

Rosaniline Dyes
type: Class
subclass of: Aniline Compounds
MCID: MC00011495
PMOID: PMO:00016101
Subclass_of: Aniline Compounds
Synonym: Aniline Compounds, Triphenylmethane
Synonym: Compounds, Triphenylmethane Aniline
Synonym: Dyes, Rosaniline
Synonym: Fuchsin
Synonym: Fuchsins
Synonym: Magentas
Synonym: Rosaniline Dyes [Chemical/Ingredient]
Synonym: Triphenylmethane Aniline Compounds
Synonym: fuchsin
Synonym: magenta
Tree Number: T6.2.6.5.15
database_cross_reference: CHV:0000010945
database_cross_reference: MSH:D012394
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000011181

Toluidines
type: Class
subclass of: Aniline Compounds
MCID: MC00012905
PMOID: PMO:00016102
Subclass_of: Aniline Compounds
Synonym: Toluidines [Chemical/Ingredient]
Tree Number: T6.2.6.5.17
database_cross_reference: MSH:D014052
database_cross_reference: NDFRT:N0000007901

Fenamates
type: Class
subclass of: Aniline Compounds
MCID: MC00628715
PMOID: PMO:00016104
Subclass_of: Aniline Compounds
Synonym: 2 Anilino Benzoates
Synonym: 2 Anilinobenzoates
Synonym: 2-Anilino-Benzoates
Synonym: 2-Anilinobenzoates
Synonym: Fenamates [Chemical/Ingredient]
Synonym: N Phenyl 2 Aminobenzoates
Synonym: N-Phenyl-2-Aminobenzoates
Tree Number: T6.2.6.5.18
database_cross_reference: MSH:D054361
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178763

Benzylamines
type: Class
subclass of: Amines
MCID: MC00001612
PMOID: PMO:00016105
Subclass_of: Amines
Synonym: Benzylamine
Synonym: Benzylamines [Chemical/Ingredient]
Synonym: benzylamine
Tree Number: T6.2.6.6
database_cross_reference: CSP:2268-4272
database_cross_reference: DRUGBANK:DB02464
database_cross_reference: MSH:D001596
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007566

Pargyline
type: Class
subclass of: Benzylamines
MCID: MC00009743
PMOID: PMO:00016106
Subclass_of: Benzylamines
Synonym: Benzenemethanamine, N-methyl-N-2-propynyl-
Synonym: N-Methyl-N-2-Propynylbenzylamine
Synonym: PARGYLINE
Synonym: Pargyline (product)
Synonym: Pargyline (substance)
Synonym: Pargyline [Chemical/Ingredient]
Synonym: antihypertensives pargyline
Synonym: pargyline
Synonym: pargyline (medication)
Tree Number: T6.2.6.6.1
database_cross_reference: ATC:C02KC01
database_cross_reference: CSP:0570-1869
database_cross_reference: CSP:2268-4272
database_cross_reference: DRUGBANK:DB01626
database_cross_reference: LNC:LP101037-2
database_cross_reference: LNC:MTHU036237
database_cross_reference: MEDCIN:340466
database_cross_reference: MSH:D010293
database_cross_reference: NCI:C66322
database_cross_reference: NCI_FDA:9MV14S8G3E
database_cross_reference: NDDF:004598
database_cross_reference: NDFRT:N0000005825
database_cross_reference: NDFRT:N0000147962
database_cross_reference: PSY:36700
database_cross_reference: RXNORM:7930
database_cross_reference: SNM:E-8911
database_cross_reference: SNMI:C-811F5
database_cross_reference: SNOMEDCT_US:21159006
database_cross_reference: SNOMEDCT_US:373749006
database_cross_reference: VANDF:4019877

Biogenic Amines
type: Class
subclass of: Amines
MCID: MC00001747
PMOID: PMO:00016107
Subclass_of: Amines
Synonym: Amine, Biogenic
Synonym: Amines, Biogenic
Synonym: Amines.biogenic
Synonym: Biogenic Amine
Synonym: Biogenic Amines [Chemical/Ingredient]
Synonym: Biogenic amine
Synonym: Biogenic amine (substance)
Synonym: Biogenic amines
Synonym: biogenic amine
Synonym: biogenic amines
Tree Number: T6.2.6.7
database_cross_reference: AOD:0000020154
database_cross_reference: CHV:0000001879
database_cross_reference: CSP:0397-6790
database_cross_reference: CSP:1549-4121
database_cross_reference: CSP:2268-5256
database_cross_reference: CSP:2268-5502
database_cross_reference: CSP:2268-5994
database_cross_reference: FMA:67161
database_cross_reference: LCH:U000565
database_cross_reference: LCH_NW:sh85014143
database_cross_reference: LNC:LP19586-4
database_cross_reference: LNC:MTHU009271
database_cross_reference: MSH:D001679
database_cross_reference: NDFRT:N0000007726
database_cross_reference: SNOMEDCT_US:117497006

Acetylcholine
type: Class
subclass of: Biogenic Amines
MCID: MC00000206
PMOID: PMO:00016108
Subclass_of: Biogenic Amines
Synonym: 2-(Acetyloxy)-N,N,N-trimethylethanaminium
Synonym: ACETYLCHOLINE
Synonym: Acetylcholine (substance)
Synonym: Acetylcholine [Chemical/Ingredient]
Synonym: Acetylcholine preparation
Synonym: Acetylcholine preparation (product)
Synonym: Acetylcholine preparation (substance)
Synonym: Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-
Synonym: Miochol E Acetylcholine Chloride Oph Soln
Synonym: Miogan Pws 20mg/vial
Tree Number: T6.2.6.7.1
database_cross_reference: AOD:0000018205
database_cross_reference: ATC:S01EB09
database_cross_reference: CHV:0000000615
database_cross_reference: CSP:0663-0733
database_cross_reference: DRUGBANK:DB03128
database_cross_reference: FMA:61789
database_cross_reference: LCH:U000028
database_cross_reference: LCH_NW:sh85000467
database_cross_reference: LNC:LA24503-7
database_cross_reference: LNC:LP15314-5
database_cross_reference: LNC:MTHU007258
database_cross_reference: MSH:D000109
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:N9YNS0M02X
database_cross_reference: NCI:C77840
database_cross_reference: NCI_FDA:N9YNS0M02X
database_cross_reference: NCI_NCI-GLOSS:CDR0000653099
database_cross_reference: NDDF:004684
database_cross_reference: NDFRT:N0000006306
database_cross_reference: NDFRT:N0000147690
database_cross_reference: PSY:00430
database_cross_reference: RXNORM:194
database_cross_reference: SNM:E-7528
database_cross_reference: SNM:F-11590
database_cross_reference: SNMI:C-67180
database_cross_reference: SNMI:F-61590
database_cross_reference: SNOMEDCT_US:13525006
database_cross_reference: SNOMEDCT_US:387074008
database_cross_reference: SNOMEDCT_US:57308006
database_cross_reference: UWDA:61789
database_cross_reference: VANDF:4019594

Biogenic Monoamines
type: Class
subclass of: Biogenic Amines
MCID: MC00001748
PMOID: PMO:00016109
Subclass_of: Biogenic Amines
Synonym: Biogenic Monoamines [Chemical/Ingredient]
Synonym: Monoamines, Biogenic
Synonym: biogenic monoamines
Tree Number: T6.2.6.7.2
database_cross_reference: AOD:0000020155
database_cross_reference: MSH:D015306
database_cross_reference: NDFRT:N0000007586

Catecholamines
type: Class
subclass of: Amines
MCID: MC00002378
PMOID: PMO:00016110
Subclass_of: Amines
Synonym: Catecholamine
Synonym: Catecholamine (substance)
Synonym: Catecholamine, NOS
Synonym: Catecholamines [Chemical/Ingredient]
Synonym: Coumel
Synonym: Sympathins
Synonym: Total catecholamines
Synonym: catecholamine
Synonym: catecholamines
Synonym: coumel
Tree Number: T6.2.6.9
database_cross_reference: AOD:0000001932
database_cross_reference: CHV:0000002525
database_cross_reference: CSP:2268-5010
database_cross_reference: FMA:61791
database_cross_reference: LCH:U000846
database_cross_reference: LCH_NW:sh85020986
database_cross_reference: LNC:LP15090-1
database_cross_reference: LNC:MTHU003446
database_cross_reference: MSH:D002395
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C88516
database_cross_reference: NCI_NCI-GLOSS:CDR0000537553
database_cross_reference: NDFRT:N0000007715
database_cross_reference: PSY:07920
database_cross_reference: RCD:X7959
database_cross_reference: SNM:F-25930
database_cross_reference: SNMI:F-B2130
database_cross_reference: SNOMEDCT_US:34582008
database_cross_reference: UWDA:61791

Dopamine
type: Class
subclass of: Catecholamines
MCID: MC00004151
PMOID: PMO:00016111
Subclass_of: Catecholamines
Synonym: 1,2-Benzenediol, 4-(2-aminoethyl)-
Synonym: 2-(3,4-Dihydroxyphenyl)ethylamine
Synonym: 3,4 Dihydroxyphenethylamine
Synonym: 3,4-Dihydroxyphenethylamine
Synonym: 3-Hydroxytyramine
Synonym: 4-(2-Aminoethyl)-1,2-benzenediol
Synonym: 4-(2-Aminoethyl)benzene-1,2-diol
Synonym: 4-(2-Aminoethyl)catechol
Synonym: 4-(2-Aminoethyl)pyrocatechol
Synonym: DOPAMINE
Tree Number: T6.2.6.9.3
database_cross_reference: AOD:0000020122
database_cross_reference: ATC:C01CA04
database_cross_reference: CHV:0000004091
database_cross_reference: CSP:2268-5256
database_cross_reference: DRUGBANK:DB00988
database_cross_reference: FMA:67238
database_cross_reference: LCH:U001449
database_cross_reference: LCH_NW:sh85039075
database_cross_reference: LNC:LA16923-7
database_cross_reference: LNC:LP15543-9
database_cross_reference: LNC:MTHU004130
database_cross_reference: MMSL:6641
database_cross_reference: MMSL:d00216
database_cross_reference: MSH:D004298
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:VTD58H1Z2X
database_cross_reference: NCI:C62025
database_cross_reference: NCI_DCP:30365
database_cross_reference: NCI_DTP:NSC0173182
database_cross_reference: NCI_FDA:VTD58H1Z2X
database_cross_reference: NDDF:004721
database_cross_reference: NDFRT:N0000006091
database_cross_reference: NDFRT:N0000147825
database_cross_reference: PDQ:CDR0000042164
database_cross_reference: PSY:14950
database_cross_reference: RCD:x01D5
database_cross_reference: RXNORM:3628
database_cross_reference: SNM:E-7471
database_cross_reference: SNM:F-25940
database_cross_reference: SNMI:C-68040
database_cross_reference: SNMI:F-B2140
database_cross_reference: SNOMEDCT_US:387443000
database_cross_reference: SNOMEDCT_US:412383006
database_cross_reference: SNOMEDCT_US:59187003
database_cross_reference: SNOMEDCT_US:77935007
database_cross_reference: UWDA:67238
database_cross_reference: VANDF:4019733

Histamine
type: Class
subclass of: Ethylamines
subclass of: PMO:00024397
MCID: MC00006286
PMOID: PMO:00016114
Subclass_of: Autacoids
Subclass_of: Ethylamines
Synonym: 1H-Imidazole-4-ethanamine
Synonym: 2-(4-Imidazolyl)ethylamine
Synonym: 2-(4-imidazolyl)ethylamine
Synonym: 4-(2-Aminoethyl)-1H-imidazole
Synonym: 4-imidazoleethylamine
Synonym: 5-Imidazoleethylamine
Synonym: 5-imidazoleethylamine
Synonym: Abee Med
Synonym: ActivOn Ultra Strength Arthritis
Synonym: Alo Therapeutic Massage
Tree Number: T6.13.10.2.2
Tree Number: T6.2.6.12.6
database_cross_reference: AOD:0000019290
database_cross_reference: CHV:0000006157
database_cross_reference: CSP:1549-4121
database_cross_reference: DRUGBANK:DB05381
database_cross_reference: FMA:61806
database_cross_reference: LCH:U002198
database_cross_reference: LCH_NW:sh85061073
database_cross_reference: LNC:LP15636-1
database_cross_reference: LNC:MTHU010971
database_cross_reference: MSH:D006632
database_cross_reference: MTH:U001984
database_cross_reference: MTHSPL:820484N8I3
database_cross_reference: NCI:C73238
database_cross_reference: NCI_FDA:820484N8I3
database_cross_reference: NCI_NCI-GLOSS:CDR0000657848
database_cross_reference: NDDF:004785
database_cross_reference: NDFRT:N0000006292
database_cross_reference: NDFRT:N0000147867
database_cross_reference: PSY:23050
database_cross_reference: RCD:X795m
database_cross_reference: RXNORM:5333
database_cross_reference: SNM:F-46640
database_cross_reference: SNMI:F-CB050
database_cross_reference: SNOMEDCT_US:54235008
database_cross_reference: UWDA:61806
database_cross_reference: VANDF:4019776

Serotonin
type: Class
subclass of: PMO:00024397
MCID: MC00011773
PMOID: PMO:00016119
Subclass_of: Autacoids
Synonym: 1H-Indol-5-ol, 3-(2-aminoethyl)-
Synonym: 3-(2-Aminoethyl)-1H-indol-5-ol
Synonym: 5 Hydroxytryptamine
Synonym: 5 ht
Synonym: 5 hydroxy tryptamine
Synonym: 5 hydroxytryptamine
Synonym: 5-HT
Synonym: 5-HT - 5-Hydroxytryptamine
Synonym: 5-Hydroxy tryptamine
Synonym: 5-Hydroxytryptamine
Tree Number: T6.13.10.2.5
database_cross_reference: AOD:0000018881
database_cross_reference: AOD:0000018883
database_cross_reference: AOD:0000028498
database_cross_reference: CHV:0000011221
database_cross_reference: CSP:0397-6790
database_cross_reference: FMA:67245
database_cross_reference: LCH:U004270
database_cross_reference: LCH_NW:sh85120301
database_cross_reference: LNC:LP14693-3
database_cross_reference: LNC:MTHU005043
database_cross_reference: MSH:D012701
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U002237
database_cross_reference: MTHSPL:333DO1RDJY
database_cross_reference: NCI:C828
database_cross_reference: NCI_DTP:NSC0058241
database_cross_reference: NCI_FDA:333DO1RDJY
database_cross_reference: NCI_NCI-GLOSS:CDR0000335511
database_cross_reference: NCI_NCI-GLOSS:CDR0000335512
database_cross_reference: NDDF:003368
database_cross_reference: NDFRT:N0000171062
database_cross_reference: PSY:23680
database_cross_reference: PSY:46740
database_cross_reference: RCD:X80Eu
database_cross_reference: RXNORM:1311214
database_cross_reference: SNM:F-46630
database_cross_reference: SNMI:F-CB040
database_cross_reference: SNOMEDCT_US:33635003
database_cross_reference: UWDA:67245

Biogenic Polyamines
type: Class
subclass of: Biogenic Amines
MCID: MC00001749
PMOID: PMO:00016122
Subclass_of: Biogenic Amines
Synonym: Biogenic Polyamines [Chemical/Ingredient]
Synonym: Polyamines, Biogenic
Synonym: biogenic polyamines
Tree Number: T6.2.6.7.3
database_cross_reference: AOD:0000020162
database_cross_reference: MSH:D015317
database_cross_reference: NDFRT:N0000166487

Spermidine
type: Class
subclass of: Polyamines
MCID: MC00012108
PMOID: PMO:00016125
Subclass_of: Polyamines
Synonym: 1,4-Butanediamine, N-(3-Aminopropyl)-
Synonym: 1,4-Butanediamine, N-(3-aminopropyl)-
Synonym: 1,4-Butanediamine, N1-(3-Aminopropyl)-
Synonym: 1,4-Diaminobutane, N-(3-Aminopropyl)-
Synonym: 1,5,10-Triazadecane
Synonym: 1,8-Diamino-4-azaoctane
Synonym: 4-Azaoctamethylenediamine
Synonym: 4-Azaoctane-1,8-Diamine
Synonym: 4-Azaoctane-1,8-diamine
Synonym: N-(3-Aminopropyl)-1,4-Butane-Diamine
Tree Number: T6.2.6.16.7
database_cross_reference: AOD:0000020165
database_cross_reference: CSP:0119-1003
database_cross_reference: DRUGBANK:DB03566
database_cross_reference: LCH:U004419
database_cross_reference: LCH_NW:sh85126549
database_cross_reference: MSH:D013095
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:U87FK77H25
database_cross_reference: NCI:C129012
database_cross_reference: NCI_FDA:U87FK77H25
database_cross_reference: NDFRT:N0000166548
database_cross_reference: RXNORM:1483262
database_cross_reference: SNM:F-11280
database_cross_reference: SNMI:F-61280
database_cross_reference: SNOMEDCT_US:111992002

Spermine
type: Class
subclass of: Polyamines
MCID: MC00012109
PMOID: PMO:00016126
Subclass_of: Polyamines
Synonym: 1,4-Bis(Aminopropyl) Butanediamine
Synonym: 1,4-Bis(Aminopropyl)Butanediamine
Synonym: 1,4-Butanediamine, N,N'-Bis(3-Aminopropyl)-
Synonym: 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-
Synonym: 1,4-Butanediamine, N1,N4-Bis(3-Aminopropyl)-
Synonym: 1,4-Diaminobutane, N,N'-Bis(3-Aminopropyl)-
Synonym: 4,9-Diaza-1,12-Dodecanediamine
Synonym: 4,9-Diaza-1,12-dodecanediamine
Synonym: 4,9-Diazadodecamethylenediamine
Synonym: 4,9-Diazadodecane-1,12-diamine
Tree Number: T6.2.6.16.8
database_cross_reference: AOD:0000020166
database_cross_reference: CSP:0119-1130
database_cross_reference: DRUGBANK:DB00127
database_cross_reference: LCH:U004420
database_cross_reference: LCH_NW:sh85126550
database_cross_reference: MSH:D013096
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2FZ7Y3VOQX
database_cross_reference: NCI:C106406
database_cross_reference: NDFRT:N0000166547
database_cross_reference: RXNORM:1483263
database_cross_reference: SNM:F-11290
database_cross_reference: SNMI:F-61290
database_cross_reference: SNOMEDCT_US:26858000

Butylamines
type: Class
subclass of: Amines
MCID: MC00002055
PMOID: PMO:00016127
Subclass_of: Amines
Synonym: Butylamines [Chemical/Ingredient]
Tree Number: T6.2.6.8
database_cross_reference: MSH:D002082
database_cross_reference: NDFRT:N0000007857

Dobutamine
type: Class
subclass of: Catecholamines
MCID: MC00004137
PMOID: PMO:00016128
Subclass_of: Catecholamines
Synonym: (+-)-4-(2-((3-(P-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
Synonym: 1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, (+-)-
Synonym: 3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
Synonym: 4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol
Synonym: DL-Dobutamine
Synonym: DOBUTAMINE
Synonym: DOBUTamine
Synonym: Dobusafe
Synonym: Dobutamin
Synonym: Dobutamina
Tree Number: T6.2.6.9.1
database_cross_reference: AOD:0000020114
database_cross_reference: ATC:C01CA07
database_cross_reference: CHV:0000004078
database_cross_reference: CSP:2268-5194
database_cross_reference: DRUGBANK:DB00841
database_cross_reference: LCH:U001442
database_cross_reference: LCH_NW:sh85038697
database_cross_reference: LNC:LP19573-2
database_cross_reference: LNC:LP208670-2
database_cross_reference: LNC:LP35685-4
database_cross_reference: LNC:MTHU008963
database_cross_reference: MMSL:d00215
database_cross_reference: MSH:D004280
database_cross_reference: MTHSPL:3S12J47372
database_cross_reference: NCI:C61733
database_cross_reference: NCI_FDA:3S12J47372
database_cross_reference: NDDF:000614
database_cross_reference: NDFRT:N0000006055
database_cross_reference: NDFRT:N0000147822
database_cross_reference: RCD:x01Ci
database_cross_reference: RXNORM:3616
database_cross_reference: SNMI:C-68030
database_cross_reference: SNOMEDCT_US:26523005
database_cross_reference: SNOMEDCT_US:387145002
database_cross_reference: VANDF:4019730

Dihydroxyphenylalanine
type: Class
subclass of: Catecholamines
MCID: MC00004150
PMOID: PMO:00016129
Subclass_of: Catecholamines
Synonym: (−)-dopa
Synonym: 3 Hydroxy DL tyrosine
Synonym: 3,4 Dihydroxyphenylalanine
Synonym: 3,4-Dihydroxyphenylalanine
Synonym: 3,4-dihydroxyphenylalanine
Synonym: 3-Hydroxy-DL-tyrosine
Synonym: DL-Tyrosine, 3-hydroxy-
Synonym: DOPA
Synonym: Dihydroxyphenylalanine (substance)
Synonym: Dihydroxyphenylalanine [Chemical/Ingredient]
Tree Number: T6.2.6.9.2
database_cross_reference: AOD:0000020115
database_cross_reference: AOD:0000028870
database_cross_reference: CHV:0000004090
database_cross_reference: CSP:0777-7405
database_cross_reference: DRUGBANK:DB01235
database_cross_reference: LCH_NW:sh87004151
database_cross_reference: MSH:D004295
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007917
database_cross_reference: PSY:14940
database_cross_reference: SNM:E-7741
database_cross_reference: SNM:F-26000
database_cross_reference: SNMI:C-67560
database_cross_reference: SNMI:F-B2200
database_cross_reference: SNOMEDCT_US:40040009
database_cross_reference: SNOMEDCT_US:65955006

Carbidopa
type: Class
subclass of: Hydrazines
MCID: MC00002221
PMOID: PMO:00016133
Subclass_of: Hydrazines
Synonym: (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic Acid
Synonym: (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate
Synonym: (S)-(-)-carbidopa
Synonym: (S)-(−)-carbidopa
Synonym: (S)-carbidopa
Synonym: (αS)-α-hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid
Synonym: Apo-levocarb - Tab 10mg/100mg
Synonym: Apo-levocarb - Tab 25mg/250mg
Synonym: Apo-levocarb CR
Synonym: Apo-levocarb-tab 25mg/100mg
Tree Number: T6.2.16.2
database_cross_reference: AOD:0000020121
database_cross_reference: CHV:0000002385
database_cross_reference: CSP:2059-0413
database_cross_reference: CSP:4003-0012
database_cross_reference: DRUGBANK:DB00190
database_cross_reference: LNC:LP17846-4
database_cross_reference: LNC:MTHU024576
database_cross_reference: MEDCIN:199115
database_cross_reference: MMSL:4355
database_cross_reference: MMSL:71847
database_cross_reference: MMSL:d00184
database_cross_reference: MSH:D002230
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:MNX7R8C5VO
database_cross_reference: NCI:C47431
database_cross_reference: NCI_FDA:MNX7R8C5VO
database_cross_reference: NDDF:001085
database_cross_reference: NDFRT:N0000005697
database_cross_reference: NDFRT:N0000146299
database_cross_reference: PDQ:CDR0000363634
database_cross_reference: PSY:07485
database_cross_reference: RXNORM:2019
database_cross_reference: SNM:E-7742
database_cross_reference: SNMI:C-B70E1
database_cross_reference: SNOMEDCT_US:386107009
database_cross_reference: SNOMEDCT_US:73579000
database_cross_reference: USPMG:MTHU000583
database_cross_reference: VANDF:4017949

Cyclohexylamines
type: Class
subclass of: Amines
MCID: MC00003420
PMOID: PMO:00016138
Subclass_of: Amines
Synonym: Cyclohexylamine
Synonym: Cyclohexylamines [Chemical/Ingredient]
Tree Number: T6.2.6.11
database_cross_reference: LCH_NW:sh2010014519
database_cross_reference: MSH:D003514
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166488

Ethylamines
type: Class
subclass of: Amines
MCID: MC00004795
PMOID: PMO:00016139
Subclass_of: Amines
Synonym: Ethylamines [Chemical/Ingredient]
Synonym: ethylamines
Tree Number: T6.2.6.12
database_cross_reference: AOD:0000020124
database_cross_reference: LCH:U001681
database_cross_reference: LCH_NW:sh85045432
database_cross_reference: MSH:D005021
database_cross_reference: NDFRT:N0000008011

Cystamine
type: Class
subclass of: Ethylamines
MCID: MC00003448
PMOID: PMO:00016140
Subclass_of: Ethylamines
Synonym: 2,2' Dithiobisethanamine
Synonym: 2,2'-Dithiobis(ethylamine)
Synonym: 2,2'-Dithiobisethanamine
Synonym: 2-Mercaptoethylamine (oxidized)
Synonym: Bis(beta-aminoethyl)disulfide
Synonym: CYSTAMINE
Synonym: Cystamine [Chemical/Ingredient]
Synonym: Cysteinamine Disulfide
Synonym: Cystinamin
Synonym: Cystineamine
Tree Number: T6.2.6.12.1
database_cross_reference: MSH:D003538
database_cross_reference: MTHSPL:R110LV8L02
database_cross_reference: NCI:C97355
database_cross_reference: NCI_FDA:R110LV8L02
database_cross_reference: NDFRT:N0000166532
database_cross_reference: RXNORM:1426401

Dibenzylchlorethamine
type: Class
subclass of: Ethylamines
MCID: MC00003838
PMOID: PMO:00016141
Subclass_of: Ethylamines
Synonym: Benzenemethanamine, N-(2-chloroethyl)-N-(phenylmethyl)-
Synonym: Chlorethylamine, Dibenzyl
Synonym: Dibenzyl Chlorethylamine
Synonym: Dibenzylchlorethamine [Chemical/Ingredient]
Tree Number: T6.2.6.12.2
database_cross_reference: MSH:D003983
database_cross_reference: NDFRT:N0000166517

Diethylamines
type: Class
subclass of: Ethylamines
MCID: MC00003887
PMOID: PMO:00016142
Subclass_of: Ethylamines
Synonym: Diethylamines [Chemical/Ingredient]
Tree Number: T6.2.6.12.3
database_cross_reference: MSH:D004048
database_cross_reference: NDFRT:N0000011408

Diethylpropion
type: Class
subclass of: Ethylamines
MCID: MC00003893
PMOID: PMO:00016144
Subclass_of: Ethylamines
Synonym: 1-Propanone, 2-(diethylamino)-1-phenyl-
Synonym: 1-phenyl-2-diethylamino-1-propanone
Synonym: 2-(Diethylamino)-1-phenyl-1-propanone
Synonym: 2-(Diethylamino)propiophenone
Synonym: 2-Diethylaminopropiophenone
Synonym: Amfepramon
Synonym: Amfepramone
Synonym: Amfepramonum
Synonym: Anfepramona
Synonym: DIETHYLPROPION
Tree Number: T6.2.6.12.4
database_cross_reference: ATC:A08AA03
database_cross_reference: CHV:0000003928
database_cross_reference: DRUGBANK:DB00937
database_cross_reference: LNC:LP19505-4
database_cross_reference: LNC:MTHU006725
database_cross_reference: MMSL:d00810
database_cross_reference: MSH:D004053
database_cross_reference: MTHSPL:Q94YYU22B8
database_cross_reference: NCI:C61721
database_cross_reference: NCI_FDA:Q94YYU22B8
database_cross_reference: NDDF:004773
database_cross_reference: NDFRT:N0000005815
database_cross_reference: NDFRT:N0000147809
database_cross_reference: RCD:x01Bv
database_cross_reference: RXNORM:3389
database_cross_reference: SNM:E-7463
database_cross_reference: SNMI:C-65030
database_cross_reference: SNOMEDCT_US:387303009
database_cross_reference: SNOMEDCT_US:54882005
database_cross_reference: VANDF:4019717

Diphenhydramine
type: Class
subclass of: Ethylamines
MCID: MC00004003
PMOID: PMO:00016145
Subclass_of: Ethylamines
Synonym: 2-(Benzhydryloxy)-N,N-dimethylethylamine
Synonym: 2-(Diphenylmethoxy)-N,N-dimethylethylamine
Synonym: 2-Diphenylmethoxy-N,N-dimethylethylamine
Synonym: 2-diphenylmethoxy-N,N-demthylethanamine
Synonym: 7 Select Allergy
Synonym: 7 Select Allergy Childrens
Synonym: 7 Select Ibuprofen PM
Synonym: 7 Select Night Time Severe Cold Cough and Flu
Synonym: 7 Select Night Time Sleep Aid
Synonym: 7 Select Night Time severe cold, cough and flu
Tree Number: T6.2.6.12.5
database_cross_reference: ATC:D04AA32
database_cross_reference: ATC:R06AA02
database_cross_reference: CCPSS:0011620
database_cross_reference: CHV:0000003981
database_cross_reference: CSP:2268-3427
database_cross_reference: DRUGBANK:DB01075
database_cross_reference: DRUGBANK:DB01593
database_cross_reference: LNC:LP16116-3
database_cross_reference: LNC:MTHU013946
database_cross_reference: LNC:MTHU019051
database_cross_reference: MEDCIN:197234
database_cross_reference: MEDCIN:199649
database_cross_reference: MMSL:d00212
database_cross_reference: MSH:D004155
database_cross_reference: MTHSPL:8GTS82S83M
database_cross_reference: NCI:C61728
database_cross_reference: NCI_DCP:01519
database_cross_reference: NCI_FDA:8GTS82S83M
database_cross_reference: NCI_NCI-GLOSS:CDR0000449930
database_cross_reference: NDDF:004787
database_cross_reference: NDFRT:N0000006794
database_cross_reference: NDFRT:N0000147816
database_cross_reference: PSY:14310
database_cross_reference: RCD:X79JE
database_cross_reference: RCD:x01E1
database_cross_reference: RXNORM:3498
database_cross_reference: SNM:E-8845
database_cross_reference: SNMI:C-51450
database_cross_reference: SNOMEDCT_US:256043008
database_cross_reference: SNOMEDCT_US:26458009
database_cross_reference: SNOMEDCT_US:372682005
database_cross_reference: USPMG:MTHU000361
database_cross_reference: VANDF:4019724

Dimenhydrinate
type: Class
subclass of: PMO:00024461
MCID: MC00003951
PMOID: PMO:00016146
Subclass_of: Drug Combinations
Synonym: (O-Benzhydryl(dimethylamino)ethanol) 8-chlorotheophyllinate
Synonym: 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
Synonym: 8-chloro-1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
Synonym: Airmit Ace
Synonym: Anti-nauseant
Synonym: Anti-nauseant Tablet
Synonym: Apo Dimenhydrinate Tab 50mg
Synonym: Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline
Synonym: Children's Motion Sickness Liq
Synonym: DIMENHYDRINATE
Tree Number: T6.15.3.19
database_cross_reference: CHV:0000003960
database_cross_reference: DRUGBANK:DB00985
database_cross_reference: LNC:LP18075-9
database_cross_reference: LNC:MTHU003001
database_cross_reference: MEDCIN:41127
database_cross_reference: MMSL:1568
database_cross_reference: MMSL:4605
database_cross_reference: MMSL:d00861
database_cross_reference: MSH:D004111
database_cross_reference: MTHSPL:JB937PER5C
database_cross_reference: NCI:C28992
database_cross_reference: NCI_FDA:JB937PER5C
database_cross_reference: NDDF:003371
database_cross_reference: NDFRT:N0000006683
database_cross_reference: NDFRT:N0000146389
database_cross_reference: RCD:dh5..
database_cross_reference: RXNORM:3444
database_cross_reference: SNM:E-8242
database_cross_reference: SNMI:C-85840
database_cross_reference: SNOMEDCT_US:387469006
database_cross_reference: SNOMEDCT_US:81073007
database_cross_reference: VANDF:4018048

Mercaptoethylamines
type: Class
subclass of: Ethylamines
subclass of: Sulfhydryl Compounds
MCID: MC00008086
PMOID: PMO:00016147
Subclass_of: Ethylamines
Subclass_of: Sulfhydryl Compounds
Synonym: Mercaptoethylamines [Chemical/Ingredient]
Tree Number: T6.2.32.6.6
Tree Number: T6.2.6.12.7
database_cross_reference: MSH:D008624
database_cross_reference: NDFRT:N0000007974

Orphenadrine
type: Class
subclass of: Ethylamines
MCID: MC00009256
PMOID: PMO:00016149
Subclass_of: Ethylamines
Synonym: 2-(phenyl-o-tolylmethoxy)ethyldimethylamine
Synonym: 2-methyldiphenhydramine
Synonym: Dimethyl-[2-(phenyl-O-tolyl-methoxy)-ethyl]-amine
Synonym: Disipal Tab 50mg
Synonym: Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-
Synonym: Methyldiphenylhydramine
Synonym: N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine
Synonym: N,N-Dimethyl-2-(phenyl(O-tolyl)methoxy)ethanamine
Synonym: N,N-Dimethyl-2-[(O-methyl-alpha-phenylbenzyl)oxy]ethylamine
Synonym: Norgesic Forte Tab
Tree Number: T6.2.6.12.8
database_cross_reference: CHV:0000009040
database_cross_reference: DRUGBANK:DB01173
database_cross_reference: LNC:LP15175-0
database_cross_reference: LNC:MTHU002564
database_cross_reference: MEDCIN:199123
database_cross_reference: MMSL:d00966
database_cross_reference: MSH:D009966
database_cross_reference: MTHSPL:AL805O9OG9
database_cross_reference: NCI:C61868
database_cross_reference: NCI_FDA:AL805O9OG9
database_cross_reference: NDDF:001648
database_cross_reference: NDFRT:N0000006810
database_cross_reference: NDFRT:N0000147952
database_cross_reference: PSY:31185
database_cross_reference: PSY:35870
database_cross_reference: RCD:x01De
database_cross_reference: RXNORM:7715
database_cross_reference: SNM:E-7988
database_cross_reference: SNMI:C-68800
database_cross_reference: SNOMEDCT_US:35035001
database_cross_reference: SNOMEDCT_US:372714007
database_cross_reference: USPMG:MTHU000716
database_cross_reference: VANDF:4019866

Phenethylamines
type: Class
subclass of: Ethylamines
MCID: MC00010009
PMOID: PMO:00016150
Subclass_of: Ethylamines
Synonym: Phenethylamine
Synonym: Phenethylamines [Chemical/Ingredient]
Synonym: Phenylethylamine
Synonym: Phenylethylamines
Synonym: benzeneethanamine
Synonym: phenethylamine
Synonym: phenethylamines
Synonym: phenylethylamine
Synonym: phenylethylamines
Synonym: β-aminoethylbenzene
Tree Number: T6.2.6.12.9
database_cross_reference: AOD:0000020127
database_cross_reference: CHV:0000009594
database_cross_reference: CSP:2268-7224
database_cross_reference: DRUGBANK:DB04325
database_cross_reference: LCH:U003608
database_cross_reference: LCH_NW:sh85100668
database_cross_reference: LNC:LP18064-3
database_cross_reference: LNC:MTHU003327
database_cross_reference: MSH:D010627
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007526
database_cross_reference: PSY:38135
database_cross_reference: PSY:38225

Mescaline
type: Class
subclass of: Alkaloids
MCID: MC00008096
PMOID: PMO:00016173
Subclass_of: Alkaloids
Synonym: 3,4,5-Trimethoxyphenethylamine
Synonym: Benzeneethanamine, 3,4,5-trimethoxy-
Synonym: Mescalin
Synonym: Mescalin substance of abuse
Synonym: Mescalin substance of abuse (substance)
Synonym: Mescaline (product)
Synonym: Mescaline (substance)
Synonym: Mescaline [Chemical/Ingredient]
Synonym: Peyote extract
Synonym: Trimethoxyphenethylamine
Tree Number: T6.3.3.12
database_cross_reference: AOD:0000000740
database_cross_reference: AOD:0000000741
database_cross_reference: CHV:0000007980
database_cross_reference: CSP:2268-7224
database_cross_reference: LCH:U002914
database_cross_reference: LCH_NW:sh85083910
database_cross_reference: LNC:LP17987-6
database_cross_reference: LNC:MTHU003041
database_cross_reference: MSH:D008635
database_cross_reference: NDFRT:N0000166902
database_cross_reference: PSY:30950
database_cross_reference: RCD:Ub18Z
database_cross_reference: SNM:E-7859
database_cross_reference: SNMI:C-63A30
database_cross_reference: SNOMEDCT_US:229008008
database_cross_reference: SNOMEDCT_US:373780001
database_cross_reference: SNOMEDCT_US:83192000

Tiapamil Hydrochloride
type: Class
subclass of: Phenyl Ethers
MCID: MC00831327
PMOID: PMO:00016176
Subclass_of: Phenyl Ethers
Synonym: 1,3-Dithiane-2-propanamine, 2-(3,4-dimethoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-N-methyl-, 1,1,3,3-tetraoxide, hydrochloride
Synonym: Hydrochloride, Tiapamil
Synonym: N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-N-methyl-m-dithian-2-propylamin-1,1,3,3-tetroxide hydrochloride
Synonym: Tiapamil Hydrochloride [Chemical/Ingredient]
Tree Number: T6.2.14.7.4
database_cross_reference: MSH:D013976
database_cross_reference: NDFRT:N0000166881

Phenoxybenzamine
type: Class
subclass of: Ethylamines
MCID: MC00010030
PMOID: PMO:00016180
Subclass_of: Ethylamines
Synonym: Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
Synonym: Fenossibenzamina
Synonym: Fenoxibenzamina
Synonym: N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine
Synonym: PHENOXYBENZAMINE
Synonym: POB
Synonym: Phenoxybenzamine (product)
Synonym: Phenoxybenzamine (substance)
Synonym: Phenoxybenzamine [Chemical/Ingredient]
Synonym: Phenoxybenzaminum
Tree Number: T6.2.6.12.10
database_cross_reference: AOD:0000020128
database_cross_reference: ATC:C04AX02
database_cross_reference: CHV:0000009605
database_cross_reference: CSP:2268-4272
database_cross_reference: DRUGBANK:DB00925
database_cross_reference: MEDCIN:340470
database_cross_reference: MMSL:d00734
database_cross_reference: MSH:D010643
database_cross_reference: MTHSPL:0TTZ664R7Z
database_cross_reference: NCI:C62065
database_cross_reference: NCI_FDA:0TTZ664R7Z
database_cross_reference: NDDF:004738
database_cross_reference: NDFRT:N0000005925
database_cross_reference: NDFRT:N0000147975
database_cross_reference: PSY:38210
database_cross_reference: RCD:x01CP
database_cross_reference: RXNORM:8149
database_cross_reference: SNM:E-7512
database_cross_reference: SNMI:C-68490
database_cross_reference: SNOMEDCT_US:372838003
database_cross_reference: SNOMEDCT_US:74771007
database_cross_reference: USPMG:MTHU000740
database_cross_reference: VANDF:4019890

Tiapride Hydrochloride
type: Class
subclass of: Ethylamines
MCID: MC00309355
PMOID: PMO:00016181
Subclass_of: Ethylamines
Synonym: Hydrochloride, Tiapride
Synonym: Monohydrochloride, Tiapride
Synonym: N,N-Diethyl-2-((2-methoxy-5-(methylsulfonyl)benzoyl)amino)ethanaminium chloride
Synonym: Tiapride Hydrochloride [Chemical/Ingredient]
Synonym: Tiapride Monohydrochloride
Synonym: tiapride HCl
Tree Number: T6.2.6.12.11
database_cross_reference: MSH:D063325
database_cross_reference: NDDF:005729
database_cross_reference: NDFRT:N0000185648

Hydroxylamines
type: Class
subclass of: Amines
MCID: MC00006503
PMOID: PMO:00016182
Subclass_of: Amines
Synonym: Hydroxylamines [Chemical/Ingredient]
Synonym: hydroxylamine
Tree Number: T6.2.6.13
database_cross_reference: CSP:0119-0117
database_cross_reference: MSH:D006898
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008238

Aminooxyacetic Acid
type: Class
subclass of: Hydroxylamines
MCID: MC00000767
PMOID: PMO:00016183
Subclass_of: Hydroxylamines
Synonym: (aminooxy)acetic acid
Synonym: AOAA
Synonym: Acetic acid, (aminooxy)-
Synonym: Acid, Aminooxyacetic
Synonym: Aminooxyacetic Acid [Chemical/Ingredient]
Synonym: Aminooxyacetic acid
Synonym: Carboxymethoxyamine
Synonym: Carboxymethoxylamine
Synonym: aminoxyacetic acid
Synonym: carboxymethoxyamine
Tree Number: T6.2.6.13.1
database_cross_reference: DRUGBANK:DB02079
database_cross_reference: MSH:D000625
database_cross_reference: NDFRT:N0000166699

Hydroxamic Acids
type: Class
subclass of: Hydroxylamines
subclass of: Hydroxy Acids
MCID: MC00006480
PMOID: PMO:00016184
Subclass_of: Hydroxy Acids
Subclass_of: Hydroxylamines
Synonym: Acid, Hydroxamic
Synonym: Acids, Hydroxamic
Synonym: Hydroxamic Acid
Synonym: Hydroxamic Acids [Chemical/Ingredient]
Synonym: Hydroxamic acids
Synonym: hydroxamic acid
Tree Number: T6.2.12.6.3
Tree Number: T6.2.6.13.2
database_cross_reference: CHV:0000006370
database_cross_reference: LCH_NW:sh90003600
database_cross_reference: MSH:D006877
database_cross_reference: NCI:C556
database_cross_reference: NDFRT:N0000007981

Ferrichrome
type: Class
subclass of: Peptides, Cyclic
MCID: MC00005040
PMOID: PMO:00016186
Subclass_of: Peptides, Cyclic
Synonym: Ferrichrome [Chemical/Ingredient]
Tree Number: T6.10.2.15.9
Tree Number: T6.4.5.4.9
database_cross_reference: MSH:D005291
database_cross_reference: NDFRT:N0000170362

Oximes
type: Class
subclass of: Hydroxylamines
MCID: MC00009571
PMOID: PMO:00016187
Subclass_of: Hydroxylamines
Synonym: Compounds, Hydroxyimino
Synonym: HYDROXYIMINO CPDS
Synonym: Hydroxyimino Compounds
Synonym: Oxime
Synonym: Oxime (substance)
Synonym: Oximes [Chemical/Ingredient]
Synonym: oxime
Synonym: oximes
Tree Number: T6.2.6.13.3
database_cross_reference: AOD:0000020131
database_cross_reference: CHV:0000009148
database_cross_reference: CSP:2187-4767
database_cross_reference: MSH:D010091
database_cross_reference: NDFRT:N0000007850
database_cross_reference: SNOMEDCT_US:440250004

Technetium Tc 99m Exametazime
type: Class
subclass of: Organotechnetium Compounds
MCID: MC00056576
PMOID: PMO:00016192
Subclass_of: Organotechnetium Compounds
Synonym: (99m)Tc HM-PAO
Synonym: (99m)Tc HMPAO
Synonym: 99m-Tc-HMPAO
Synonym: 99mTc-HMPAO
Synonym: Drax Exametazime
Synonym: TC HMPAO
Synonym: TC HMPAO 099M
Synonym: TECHNETIUM TC EXAMETAZIME 099M
Synonym: TECHNETIUM TC HEXAMETHYLPROPYLENEAMINE OXIME 099M
Synonym: TECHNETIUM TC-99M EXAMETAZIME
Tree Number: T6.2.28.13.6
database_cross_reference: ATC:V09AA01
database_cross_reference: DRUGBANK:DB09163
database_cross_reference: LNC:LP208688-4
database_cross_reference: MSH:D019690
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:3B744AG22N
database_cross_reference: NCI:C87402
database_cross_reference: NCI_FDA:3B744AG22N
database_cross_reference: NDDF:009748
database_cross_reference: NDFRT:N0000166771
database_cross_reference: RXNORM:1431726
database_cross_reference: SNMI:C-B1223
database_cross_reference: SNOMEDCT_US:77313009

4-Hydroxyaminoquinoline-1-oxide
type: Class
subclass of: Hydroxylamines
subclass of: Cyclic N-Oxides
MCID: MC00000077
PMOID: PMO:00016193
Subclass_of: Cyclic N-Oxides
Subclass_of: Hydroxylamines
Synonym: 4 Hydroxyaminoquinoline 1 oxide
Synonym: 4 Hydroxyaminoquinoline N oxide
Synonym: 4-Hydroxyaminoquinoline-1-oxide [Chemical/Ingredient]
Synonym: 4-Hydroxyaminoquinoline-N-oxide
Synonym: 4-Quinolinamine, N-hydroxy-, 1-oxide
Synonym: HYDROXYAMINOQUINOLINE A OXIDE 04 01
Synonym: HYDROXYAMINOQUINOLINE N OXIDE 04
Tree Number: T6.2.6.13.4
Tree Number: T6.3.6.1.2
database_cross_reference: MSH:D015108
database_cross_reference: NDFRT:N0000167040

Mannich Bases
type: Class
subclass of: Amines
subclass of: Ketones
MCID: MC00007890
PMOID: PMO:00016194
Subclass_of: Amines
Subclass_of: Ketones
Synonym: Bases, Mannich
Synonym: Mannich Bases [Chemical/Ingredient]
Synonym: Mannich base
Synonym: Mannich bases
Tree Number: T6.2.20.10
Tree Number: T6.2.6.14
database_cross_reference: CSP:0118-9355
database_cross_reference: LCH_NW:sh94002475
database_cross_reference: MSH:D008352
database_cross_reference: NDFRT:N0000166791

Methylamines
type: Class
subclass of: Amines
MCID: MC00008212
PMOID: PMO:00016195
Subclass_of: Amines
Synonym: Methylamines [Chemical/Ingredient]
Tree Number: T6.2.6.15
database_cross_reference: LCH:U002942
database_cross_reference: LCH_NW:sh85084423
database_cross_reference: MSH:D008744
database_cross_reference: NDFRT:N0000008122

Dimethylamines
type: Class
subclass of: Methylamines
MCID: MC00003963
PMOID: PMO:00016196
Subclass_of: Methylamines
Synonym: Dimethylamines [Chemical/Ingredient]
Tree Number: T6.2.6.15.1
database_cross_reference: MSH:D004123
database_cross_reference: NDFRT:N0000007671

Polyamines
type: Class
subclass of: Amines
MCID: MC00010397
PMOID: PMO:00016198
Subclass_of: Amines
Synonym: Polyamine
Synonym: Polyamine (substance)
Synonym: Polyamine Compound
Synonym: Polyamines [Chemical/Ingredient]
Synonym: polyamine
Synonym: polyamines
Tree Number: T6.2.6.16
database_cross_reference: CHV:0000009903
database_cross_reference: CSP:0119-0759
database_cross_reference: LCH:U003750
database_cross_reference: LCH_NW:sh85104589
database_cross_reference: MSH:D011073
database_cross_reference: NCI:C759
database_cross_reference: NDFRT:N0000007662
database_cross_reference: SNOMEDCT_US:415130003

Sevelamer
type: Class
subclass of: Polyamines
MCID: MC00240736
PMOID: PMO:00016199
Subclass_of: Polyamines
Synonym: 2-Propen-1-amine, Polymer with (Chloromethyl)oxirane
Synonym: Allylamine Polymer with 1-Chloro-2,3-epoxypropane
Synonym: Allylamine-epichlorohydrin Copolymer
Synonym: Phosblock
Synonym: SEVELAMER
Synonym: Sevelamer (product)
Synonym: Sevelamer (substance)
Synonym: Sevelamer [Chemical/Ingredient]
Synonym: Sevelamero
Synonym: Sevelamerum
Tree Number: T6.2.6.16.1
database_cross_reference: ATC:V03AE02
database_cross_reference: CHV:0000045217
database_cross_reference: DRUGBANK:DB00658
database_cross_reference: MMSL:d04363
database_cross_reference: MSH:D000069603
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:941N5DUU5C
database_cross_reference: NCI:C84172
database_cross_reference: NCI_FDA:941N5DUU5C
database_cross_reference: NDDF:007676
database_cross_reference: NDFRT:N0000007344
database_cross_reference: NDFRT:N0000022136
database_cross_reference: RXNORM:214824
database_cross_reference: SNOMEDCT_US:329195003
database_cross_reference: SNOMEDCT_US:395871000
database_cross_reference: USPMG:MTHU001225
database_cross_reference: VANDF:4024131

Colestipol
type: Class
subclass of: Polyamines
subclass of: Polymers
MCID: MC00003054
PMOID: PMO:00016200
Subclass_of: Polyamines
Subclass_of: Polymers
Synonym: COLESTIPOL
Synonym: Cholestabyl
Synonym: Colestid Orange Granules
Synonym: Colestid Tablets 1 G
Synonym: Colestipol (product)
Synonym: Colestipol (substance)
Synonym: Colestipol [Chemical/Ingredient]
Synonym: Colestipolum
Synonym: Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane
Synonym: Epichlorohydrin-tetraethylenepentamine polymer
Tree Number: T6.14.9.2
Tree Number: T6.2.6.16.2
Tree Number: T6.5.2.4
database_cross_reference: ATC:C10AC02
database_cross_reference: CHV:0000003147
database_cross_reference: CSP:0658-5530
database_cross_reference: DRUGBANK:DB00375
database_cross_reference: MMSL:d00744
database_cross_reference: MSH:D003084
database_cross_reference: MTHSPL:K50N755924
database_cross_reference: NCI:C81540
database_cross_reference: NCI_FDA:K50N755924
database_cross_reference: NDDF:004708
database_cross_reference: NDFRT:N0000006745
database_cross_reference: NDFRT:N0000147784
database_cross_reference: RCD:x01R0
database_cross_reference: RXNORM:2685
database_cross_reference: SNMI:C-80640
database_cross_reference: SNOMEDCT_US:372811005
database_cross_reference: SNOMEDCT_US:66971004
database_cross_reference: USPMG:MTHU000994
database_cross_reference: VANDF:4019692

Diamines
type: Class
subclass of: Polyamines
MCID: MC00003813
PMOID: PMO:00016201
Subclass_of: Polyamines
Synonym: Diamine
Synonym: Diamine (substance)
Synonym: Diamines [Chemical/Ingredient]
Synonym: diamine
Tree Number: T6.2.6.16.3
database_cross_reference: CHV:0000003861
database_cross_reference: CSP:0118-9736
database_cross_reference: MSH:D003959
database_cross_reference: NDFRT:N0000008224
database_cross_reference: RCD:X79B4
database_cross_reference: SNOMEDCT_US:255760002

Aminophylline
type: Class
subclass of: PMO:00024461
MCID: MC00000770
PMOID: PMO:00016203
Subclass_of: Drug Combinations
Synonym: 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)
Synonym: 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1)
Synonym: AMINOPHYLLINE
Synonym: Aminophylline (product)
Synonym: Aminophylline (substance)
Synonym: Aminophylline - chemical
Synonym: Aminophylline - chemical (substance)
Synonym: Aminophylline Inj 50mg/ml
Synonym: Aminophylline Injection 50mg/ml
Synonym: Aminophylline Tab 0.1gm
Tree Number: T6.15.3.17
database_cross_reference: ATC:R03DA05
database_cross_reference: CHV:0000001018
database_cross_reference: CSP:2503-3703
database_cross_reference: DRUGBANK:DB01223
database_cross_reference: MEDCIN:41459
database_cross_reference: MMSL:3058
database_cross_reference: MMSL:4172
database_cross_reference: MMSL:d00758
database_cross_reference: MSH:D000628
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:27Y3KJK423
database_cross_reference: NCI:C47393
database_cross_reference: NCI_DCP:06095
database_cross_reference: NCI_FDA:27Y3KJK423
database_cross_reference: NDDF:000608
database_cross_reference: NDFRT:N0000005738
database_cross_reference: NDFRT:N0000146397
database_cross_reference: RCD:c41..
database_cross_reference: RXNORM:689
database_cross_reference: SNMI:C-69520
database_cross_reference: SNOMEDCT_US:373508009
database_cross_reference: SNOMEDCT_US:391758000
database_cross_reference: SNOMEDCT_US:55867006
database_cross_reference: USPMG:MTHU001653
database_cross_reference: VANDF:4018056

Pentetic Acid
type: Class
subclass of: Polyamines
MCID: MC00004196
PMOID: PMO:00016210
Subclass_of: Polyamines
Synonym: (Diethylenetriamine)pentaacetic acid
Synonym: Acid, Diethylenetriamine Pentaacetic
Synonym: DETAPAC
Synonym: DIETHYLENETRIAMINE PENTAACETIC ACID
Synonym: DTPA
Synonym: DTPA - Diethylenetriaminepentaacetic acid
Synonym: Detapac
Synonym: Diethylenetriamine Pentaacetic Acid
Synonym: Diethylenetriamine-N,N,N',N'',N''-pentaacetic Acid
Synonym: Diethylenetriaminepentaacetic acid
Tree Number: T6.2.6.16.4
database_cross_reference: CHV:0000004166
database_cross_reference: CSP:0124-2496
database_cross_reference: LCH:U005484
database_cross_reference: LCH_NW:sh85037868
database_cross_reference: LNC:LP34996-6
database_cross_reference: MMSL:194369
database_cross_reference: MMSL:28970
database_cross_reference: MMSL:d07922
database_cross_reference: MSH:D004369
database_cross_reference: MTHSPL:7A314HQM0I
database_cross_reference: NCI:C460
database_cross_reference: NCI_DTP:NSC0007340
database_cross_reference: NCI_FDA:7A314HQM0I
database_cross_reference: NDDF:006655
database_cross_reference: NDDF:009768
database_cross_reference: NDFRT:N0000006954
database_cross_reference: NDFRT:N0000146524
database_cross_reference: NDFRT:N0000147679
database_cross_reference: PDQ:CDR0000042451
database_cross_reference: RXNORM:3690
database_cross_reference: SNOMEDCT_US:429352009
database_cross_reference: SNOMEDCT_US:429461005
database_cross_reference: VANDF:4018190
database_cross_reference: VANDF:4019580

Technetium Tc 99m Pentetate
type: Class
subclass of: Organotechnetium Compounds
MCID: MC00041255
PMOID: PMO:00016211
Subclass_of: Organotechnetium Compounds
Synonym: 99m-DTPA, Tc
Synonym: 99m-technetium Diethylenetriaminepentaacetic Acid
Synonym: TC DTPA 099M
Synonym: TCDTPA
Synonym: TECHNETIUM 99M PENTETATE
Synonym: TECHNETIUM TC PENTETATE 099M
Synonym: TECHNETIUM TC-99M PENTETATE
Synonym: Tc 99m DTPA
Synonym: Tc 99m-DTPA
Synonym: Tc-99m DTPA
Tree Number: T6.2.28.13.3
database_cross_reference: CHV:0000015316
database_cross_reference: LNC:LP208683-5
database_cross_reference: MSH:D016284
database_cross_reference: NCI:C87406
database_cross_reference: NCI:C95205
database_cross_reference: NCI_FDA:VW78417PU1
database_cross_reference: NDFRT:N0000166768
database_cross_reference: SNM:E-5278
database_cross_reference: SNOMEDCT_US:430276001

Gadolinium DTPA
type: Class
subclass of: Organometallic Compounds
MCID: MC00027281
PMOID: PMO:00016212
Subclass_of: Organometallic Compounds
Synonym: DTPA, Gadolinium
Synonym: Diethylenetriaminepenta-acetic Acid, Gadolinium
Synonym: GADOPENTETIC ACID
Synonym: Gadolinium DTPA [Chemical/Ingredient]
Synonym: Gadolinium Diethylenetriaminepenta acetic Acid
Synonym: Gadolinium Diethylenetriaminepenta-acetic Acid
Synonym: Gadopentetic Acid
Synonym: Gadopentetic acid
Synonym: Gadopentetic acid (substance)
Synonym: Gd DTPA
Tree Number: T6.2.28.14
database_cross_reference: ATC:V08CA01
database_cross_reference: CHV:0000014063
database_cross_reference: DRUGBANK:DB00789
database_cross_reference: MSH:D019786
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2588
database_cross_reference: NCI:C87737
database_cross_reference: NCI_FDA:K2I13DR72L
database_cross_reference: NCI_NCI-GLOSS:CDR0000546740
database_cross_reference: NDDF:004527
database_cross_reference: NDFRT:N0000006865
database_cross_reference: PDQ:CDR0000037987
database_cross_reference: SNOMEDCT_US:710811005

Hexadimethrine Bromide
type: Class
subclass of: Polyamines
subclass of: Polymers
MCID: MC00006234
PMOID: PMO:00016213
Subclass_of: Polyamines
Subclass_of: Polymers
Synonym: 1,5-Dimethyl-1,5-Diazaundecamethylene Polymethobromide
Synonym: 1,6-Hexanediamine, N,N,N',N'-tetramethyl-, polymer with 1,3-dibromopropane
Synonym: Bromide, Hexadimethrine
Synonym: Hexadimethrine
Synonym: Hexadimethrine (substance)
Synonym: Hexadimethrine - chemical
Synonym: Hexadimethrine - chemical (substance)
Synonym: Hexadimethrine Bromide [Chemical/Ingredient]
Synonym: hexadimethrine
Synonym: hexadimethrine bromide
Tree Number: T6.14.9.5
Tree Number: T6.2.6.16.5
Tree Number: T6.5.2.7
database_cross_reference: CHV:0000006120
database_cross_reference: MSH:D006583
database_cross_reference: NDFRT:N0000171533
database_cross_reference: SNOMEDCT_US:118258004
database_cross_reference: SNOMEDCT_US:363741008

Methenamine
type: Class
subclass of: Polyamines
MCID: MC00008174
PMOID: PMO:00016214
Subclass_of: Polyamines
Synonym: 1,3,5,7-Tetraazatricyclo(3.3.1.13,7)decane
Synonym: 1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane
Synonym: Azo Urinary Tract Defense Antibacterial Protection
Synonym: CVS Antibacterial Plus Urinary Pain Relief
Synonym: Cystex Plus
Synonym: HMT
Synonym: HMTA
Synonym: Hexamethylenetetram (Hexamin)
Synonym: Hexamethylenetetramine
Synonym: Hexamethylenetetramine (Hexamin)
Tree Number: T6.2.6.16.6
database_cross_reference: ATC:J01XX05
database_cross_reference: CHV:0000008034
database_cross_reference: DRUGBANK:DB06799
database_cross_reference: LCH_NW:sh2011002550
database_cross_reference: LNC:LP28592-1
database_cross_reference: MEDCIN:41520
database_cross_reference: MMSL:5069
database_cross_reference: MMSL:72179
database_cross_reference: MMSL:d00106
database_cross_reference: MSH:D008709
database_cross_reference: MTHSPL:J50OIX95QV
database_cross_reference: NCI:C61841
database_cross_reference: NCI_FDA:J50OIX95QV
database_cross_reference: NDDF:002861
database_cross_reference: NDFRT:N0000007322
database_cross_reference: NDFRT:N0000146894
database_cross_reference: RCD:X79FD
database_cross_reference: RXNORM:6832
database_cross_reference: SNM:E-5708
database_cross_reference: SNMI:C-55610
database_cross_reference: SNOMEDCT_US:255894008
database_cross_reference: SNOMEDCT_US:372773008
database_cross_reference: SNOMEDCT_US:411252008
database_cross_reference: SNOMEDCT_US:56123002
database_cross_reference: USPMG:MTHU000240
database_cross_reference: VANDF:4018578

Propylamines
type: Class
subclass of: Amines
MCID: MC00010731
PMOID: PMO:00016215
Subclass_of: Amines
Synonym: Propylamine
Synonym: Propylamine (substance)
Synonym: Propylamine, NOS
Synonym: Propylamines [Chemical/Ingredient]
Synonym: propylamine
Tree Number: T6.2.6.17
database_cross_reference: AOD:0000020110
database_cross_reference: LCH:U003864
database_cross_reference: LCH_NW:sh85107557
database_cross_reference: MSH:D011437
database_cross_reference: NDFRT:N0000007691
database_cross_reference: RCD:X80CM
database_cross_reference: SNMI:C-51600
database_cross_reference: SNOMEDCT_US:259273007
database_cross_reference: SNOMEDCT_US:58502006

Atomoxetine Hydrochloride
type: Class
subclass of: Propylamines
MCID: MC00397211
PMOID: PMO:00016216
Subclass_of: Propylamines
Synonym: (-)-N -Methyl-3-phenyl-3-(o-tolyloxy)-propylamine Hydrochloride
Synonym: (-)-N -methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride
Synonym: (-)-N-methyl-gamma(2-methylphenoxy)benzenepropamine Hydrochloride
Synonym: ATOMOXETINE HCL
Synonym: ATOMOXETINE HYDROCHLORIDE
Synonym: Atomoxetine HCl
Synonym: Atomoxetine Hydrochloride [Chemical/Ingredient]
Synonym: Atomoxetine hydrochloride
Synonym: Atomoxetine hydrochloride (substance)
Synonym: HCl, Atomoxetine
Tree Number: T6.2.6.17.1
database_cross_reference: DRUGBANK:DB00289
database_cross_reference: MEDCIN:258262
database_cross_reference: MMSL:17042
database_cross_reference: MMSL:192105
database_cross_reference: MSH:D000069445
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:57WVB6I2W0
database_cross_reference: NCI:C47405
database_cross_reference: NCI_FDA:57WVB6I2W0
database_cross_reference: NDDF:009863
database_cross_reference: NDFRT:N0000148783
database_cross_reference: NDFRT:N0000191944
database_cross_reference: PDQ:CDR0000475797
database_cross_reference: RXNORM:353103
database_cross_reference: SNOMEDCT_US:412577007
database_cross_reference: USPMG:MTHU001084
database_cross_reference: VANDF:4021364

Clorgyline
type: Class
subclass of: Propylamines
MCID: MC00002979
PMOID: PMO:00016217
Subclass_of: Propylamines
Synonym: 2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-
Synonym: CLORGILINE
Synonym: Chlorgyline
Synonym: Clorgilin
Synonym: Clorgiline
Synonym: Clorgyline [Chemical/Ingredient]
Synonym: clorgyline
Tree Number: T6.2.6.17.2
database_cross_reference: CHV:0000003065
database_cross_reference: MSH:D003010
database_cross_reference: NCI:C77522
database_cross_reference: NCI_FDA:LYJ16FZU9Q
database_cross_reference: NDFRT:N0000166516

Fluoxetine
type: Class
subclass of: Propylamines
MCID: MC00005208
PMOID: PMO:00016218
Subclass_of: Propylamines
Synonym: (+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-P-tolyl)oxy)propylamine
Synonym: (+/-)-Fluoxetine
Synonym: (R)-(+/-)-Fluoxetine
Synonym: (R)-Fluoxetine
Synonym: (S)-(−)-fluoxetine
Synonym: (S)-Fluoxetine
Synonym: (S)-N-methyl-3-(4-trifluoromethylphenoxy)-3-phenylpropylamine
Synonym: (S)-N-methyl-3-(4-trifluoromethylphenyloxy)-3-(phenyl)propylamine
Synonym: (S)-N-methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine
Tree Number: T6.2.6.17.3
database_cross_reference: AOD:0000020111
database_cross_reference: ATC:N06AB03
database_cross_reference: CHV:0000005130
database_cross_reference: CSP:4001-0056
database_cross_reference: DRUGBANK:DB00472
database_cross_reference: DRUGBANK:DB08472
database_cross_reference: DRUGBANK:DB08544
database_cross_reference: LCH_NW:sh90005418
database_cross_reference: LNC:LP14381-5
database_cross_reference: LNC:MTHU003396
database_cross_reference: MMSL:17711
database_cross_reference: MMSL:d00236
database_cross_reference: MSH:D005473
database_cross_reference: MTHSPL:01K63SUP8D
database_cross_reference: NCI:C506
database_cross_reference: NCI_FDA:01K63SUP8D
database_cross_reference: NCI_NCI-GLOSS:CDR0000045374
database_cross_reference: NDDF:004613
database_cross_reference: NDFRT:N0000007101
database_cross_reference: NDFRT:N0000147852
database_cross_reference: PDQ:CDR0000041578
database_cross_reference: PSY:19967
database_cross_reference: RCD:x01Ar
database_cross_reference: RXNORM:4493
database_cross_reference: SNMI:C-62290
database_cross_reference: SNOMEDCT_US:372767007
database_cross_reference: SNOMEDCT_US:53640004
database_cross_reference: USPMG:MTHU000306
database_cross_reference: VANDF:4019761

Mexiletine
type: Class
subclass of: Propylamines
MCID: MC00008270
PMOID: PMO:00016219
Subclass_of: Propylamines
Synonym: (+-)-1-(2,6-Dimethylphenoxy)propan-2-amine
Synonym: (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane
Synonym: 1-(2',6'-Dimethylphenoxy)-2-aminopropane
Synonym: 1-(2,6-Dimethylphenoxy)-2-propanamine
Synonym: 1-Methyl-2-(2,6-xylyloxy)ethanamine
Synonym: 1-Methyl-2-(2,6-xylyloxy)ethylamine
Synonym: 2-Propanamine, 1-(2,6-dimethylphenoxy)-
Synonym: Alti-mexiletine
Synonym: Cirumimeru
Synonym: MEXILETINE
Tree Number: T6.2.6.17.4
database_cross_reference: ATC:C01BB02
database_cross_reference: CHV:0000008079
database_cross_reference: CSP:4008-0065
database_cross_reference: DRUGBANK:DB00379
database_cross_reference: LCH:U002953
database_cross_reference: LCH_NW:sh85084629
database_cross_reference: LNC:LP16205-4
database_cross_reference: LNC:MTHU004263
database_cross_reference: MEDCIN:44444
database_cross_reference: MMSL:d00300
database_cross_reference: MSH:D008801
database_cross_reference: MTHSPL:1U511HHV4Z
database_cross_reference: NCI:C62047
database_cross_reference: NCI_FDA:1U511HHV4Z
database_cross_reference: NDDF:004485
database_cross_reference: NDFRT:N0000006486
database_cross_reference: NDFRT:N0000147925
database_cross_reference: RCD:x01QK
database_cross_reference: RXNORM:6926
database_cross_reference: SNMI:C-804B0
database_cross_reference: SNOMEDCT_US:372909002
database_cross_reference: SNOMEDCT_US:96298001
database_cross_reference: USPMG:MTHU000901
database_cross_reference: VANDF:4019837

Promethazine
type: Class
subclass of: Propylamines
subclass of: Phenothiazines
MCID: MC00010690
PMOID: PMO:00016220
Subclass_of: Phenothiazines
Subclass_of: Propylamines
Synonym: (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
Synonym: 10-(2-Dimethylaminopropyl)phenothiazine
Synonym: 10-[2-(dimethylamino)Propyl]phenothiazine
Synonym: 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-
Synonym: Diprazinum
Synonym: Fargan
Synonym: Farganesse
Synonym: Histantil Tab 25mg
Synonym: Histantil Tab 50mg
Synonym: Lergigan
Tree Number: T6.2.32.5.13
Tree Number: T6.2.6.17.5
database_cross_reference: AOD:0000020958
database_cross_reference: ATC:D04AA10
database_cross_reference: ATC:R06AD02
database_cross_reference: CHV:0000010179
database_cross_reference: CSP:2264-4570
database_cross_reference: DRUGBANK:DB01069
database_cross_reference: LCH_NW:sh2007005455
database_cross_reference: LNC:LP15006-7
database_cross_reference: LNC:MTHU001492
database_cross_reference: MMSL:d00787
database_cross_reference: MSH:D011398
database_cross_reference: MTHSPL:FF28EJQ494
database_cross_reference: NCI:C779
database_cross_reference: NCI_DTP:NSC0030321
database_cross_reference: NCI_FDA:FF28EJQ494
database_cross_reference: NDDF:004459
database_cross_reference: NDFRT:N0000006007
database_cross_reference: NDFRT:N0000147995
database_cross_reference: PSY:41050
database_cross_reference: RCD:X79JO
database_cross_reference: RCD:dhf..
database_cross_reference: RCD:x00A2
database_cross_reference: RXNORM:8745
database_cross_reference: SNM:E-7943
database_cross_reference: SNMI:C-62820
database_cross_reference: SNOMEDCT_US:256051006
database_cross_reference: SNOMEDCT_US:322154000
database_cross_reference: SNOMEDCT_US:372871004
database_cross_reference: SNOMEDCT_US:8372007
database_cross_reference: USPMG:MTHU000374
database_cross_reference: VANDF:4019910

Tranylcypromine
type: Class
subclass of: Propylamines
MCID: MC00013018
PMOID: PMO:00016221
Subclass_of: Propylamines
Synonym: (Â±)-trans-2-phenylcyclopropylamine
Synonym: Cyclopropanamine, 2-phenyl-, trans-(+-)-
Synonym: MAOI - Tranylcypromine
Synonym: TRANYLCYPROMINE
Synonym: Tranilcipromina
Synonym: Trans-2-Phenylcyclopropylamine
Synonym: Tranylcypromin
Synonym: Tranylcypromine (product)
Synonym: Tranylcypromine (substance)
Synonym: Tranylcypromine [Chemical/Ingredient]
Tree Number: T6.2.6.17.6
database_cross_reference: ATC:N06AF04
database_cross_reference: CHV:0000012493
database_cross_reference: DRUGBANK:DB00752
database_cross_reference: DRUGBANK:DB02665
database_cross_reference: LNC:LP14552-1
database_cross_reference: LNC:MTHU001574
database_cross_reference: MEDCIN:340489
database_cross_reference: MMSL:d00884
database_cross_reference: MSH:D014191
database_cross_reference: MTHSPL:3E3V44J4Z9
database_cross_reference: NCI:C61979
database_cross_reference: NCI_DCP:01583
database_cross_reference: NCI_FDA:3E3V44J4Z9
database_cross_reference: NDDF:004597
database_cross_reference: NDFRT:N0000007022
database_cross_reference: NDFRT:N0000148038
database_cross_reference: PSY:54090
database_cross_reference: RCD:d84..
database_cross_reference: RXNORM:10734
database_cross_reference: SNM:E-7946
database_cross_reference: SNMI:C-62430
database_cross_reference: SNOMEDCT_US:372891006
database_cross_reference: SNOMEDCT_US:89092006
database_cross_reference: USPMG:MTHU000298
database_cross_reference: VANDF:4019953

Citalopram
type: Class
subclass of: Propylamines
subclass of: Nitriles
MCID: MC00002924
PMOID: PMO:00016222
Subclass_of: Nitriles
Subclass_of: Propylamines
Synonym: 1,3-Dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile
Synonym: 5-Isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-
Synonym: Abbott-citalopram
Synonym: Accel-citalopram Tablets
Synonym: Act Citalopram
Synonym: Ag-citalopram
Synonym: Akarin
Synonym: Apo-citalopram
Synonym: Auro-citalopram
Synonym: Ava-citalopram
Tree Number: T6.2.23.11
Tree Number: T6.2.6.17.7
database_cross_reference: AOD:0000020112
database_cross_reference: ATC:N06AB04
database_cross_reference: CHV:0000003009
database_cross_reference: CSP:5002-0018
database_cross_reference: DRUGBANK:DB00215
database_cross_reference: LNC:LP20806-3
database_cross_reference: LNC:MTHU012380
database_cross_reference: MMSL:d04332
database_cross_reference: MSH:D015283
database_cross_reference: MTHSPL:0DHU5B8D6V
database_cross_reference: NCI:C61680
database_cross_reference: NCI_FDA:0DHU5B8D6V
database_cross_reference: NCI_NCI-GLOSS:CDR0000450095
database_cross_reference: NDDF:005106
database_cross_reference: NDFRT:N0000007127
database_cross_reference: NDFRT:N0000148583
database_cross_reference: PSY:09265
database_cross_reference: RCD:da9..
database_cross_reference: RXNORM:2556
database_cross_reference: SNOMEDCT_US:321986007
database_cross_reference: SNOMEDCT_US:372596005
database_cross_reference: USPMG:MTHU000302
database_cross_reference: VANDF:4021129

1-Naphthylamine
type: Class
subclass of: Amines
subclass of: Naphthalenes
MCID: MC00000009
PMOID: PMO:00016223
Subclass_of: Amines
Subclass_of: Naphthalenes
Synonym: 1 Aminonaphthalene
Synonym: 1 Naphthylamine
Synonym: 1-Aminonaphthalene
Synonym: 1-Naphthalenamine
Synonym: 1-Naphthylamine [Chemical/Ingredient]
Synonym: 1-Naththylamine
Synonym: 1-Naththylamine (substance)
Synonym: 1-naphthylamine
Synonym: 8 Aminonaphthalene
Synonym: 8-Aminonaphthalene
Tree Number: T6.2.6.18
Tree Number: T6.4.3.7.16
database_cross_reference: CHV:0000000502
database_cross_reference: MSH:D015057
database_cross_reference: NDFRT:N0000007745
database_cross_reference: SNM:E-6946
database_cross_reference: SNMI:C-29040
database_cross_reference: SNOMEDCT_US:13579002

Sertraline
type: Class
subclass of: 1-Naphthylamine
MCID: MC00037640
PMOID: PMO:00016224
Subclass_of: 1-Naphthylamine
Synonym: (+)-Sertraline
Synonym: (1S,4S)-Sertraline
Synonym: (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine
Synonym: 1-Naphthalenamine,1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)-
Synonym: Act Sertraline
Synonym: Auro-sertraline
Synonym: Bio-sertraline
Synonym: Dom-sertraline
Synonym: Gd-sertraline
Synonym: Ipg-sertraline
Tree Number: T6.2.6.18.1
database_cross_reference: AOD:0000019780
database_cross_reference: ATC:N06AB06
database_cross_reference: CHV:0000014797
database_cross_reference: CSP:4006-0085
database_cross_reference: DRUGBANK:DB01104
database_cross_reference: LCH_NW:sh93006171
database_cross_reference: LNC:LP17242-6
database_cross_reference: LNC:MTHU004268
database_cross_reference: MMSL:d00880
database_cross_reference: MSH:D020280
database_cross_reference: MTHSPL:QUC7NX6WMB
database_cross_reference: NCI:C61939
database_cross_reference: NCI_FDA:QUC7NX6WMB
database_cross_reference: NCI_NCI-GLOSS:CDR0000335513
database_cross_reference: NDDF:004615
database_cross_reference: NDFRT:N0000005919
database_cross_reference: NDFRT:N0000148257
database_cross_reference: PDQ:CDR0000322832
database_cross_reference: PSY:46765
database_cross_reference: RCD:da5..
database_cross_reference: RXNORM:36437
database_cross_reference: SNMI:C-62320
database_cross_reference: SNOMEDCT_US:321958004
database_cross_reference: SNOMEDCT_US:372594008
database_cross_reference: SNOMEDCT_US:96211006
database_cross_reference: USPMG:MTHU000312
database_cross_reference: VANDF:4020551

2-Naphthylamine
type: Class
subclass of: Amines
subclass of: Naphthalenes
MCID: MC00000045
PMOID: PMO:00016225
Subclass_of: Amines
Subclass_of: Naphthalenes
Synonym: 2 Aminonaphthalene
Synonym: 2 Naphthylamine
Synonym: 2-Aminonaphthalene
Synonym: 2-Naphthalenamine
Synonym: 2-Naphthylamine (substance)
Synonym: 2-Naphthylamine [Chemical/Ingredient]
Synonym: AMINONAPHTHALENE 02
Synonym: Beta-naphthylamine
Synonym: Fast Scarlet Base B
Synonym: NAPHTHYLAMINE 02
Tree Number: T6.2.6.19
Tree Number: T6.4.3.7.18
database_cross_reference: MSH:D015081
database_cross_reference: NCI:C44311
database_cross_reference: NDFRT:N0000167383
database_cross_reference: SNM:E-6947
database_cross_reference: SNMI:C-29041
database_cross_reference: SNOMEDCT_US:26822007

Anhydrides
type: Class
subclass of: Organic Chemicals
MCID: MC00000938
PMOID: PMO:00016226
Subclass_of: Organic Chemicals
Synonym: Anhydride
Synonym: Anhydrides [Chemical/Ingredient]
Synonym: anhydride
Synonym: anhydrides
Tree Number: T6.2.7
database_cross_reference: AOD:0000001404
database_cross_reference: CHV:0000001190
database_cross_reference: LCH:U000252
database_cross_reference: LCH_NW:sh85005152
database_cross_reference: LNC:LP28422-1
database_cross_reference: MSH:D000812
database_cross_reference: NDFRT:N0000166564

Acetic Anhydrides
type: Class
subclass of: Anhydrides
MCID: MC00000182
PMOID: PMO:00016227
Subclass_of: Anhydrides
Synonym: Acetic Anhydrides [Chemical/Ingredient]
Synonym: Anhydrides, Acetic
Tree Number: T6.2.7.1
database_cross_reference: MSH:D000089
database_cross_reference: NDFRT:N0000166700

Citraconic Anhydrides
type: Class
subclass of: Anhydrides
subclass of: Furans
MCID: MC00002927
PMOID: PMO:00016228
Subclass_of: Anhydrides
Subclass_of: Furans
Synonym: Anhydrides, Citraconic
Synonym: Anhydrides, Methylmaleic
Synonym: Citraconic Anhydrides [Chemical/Ingredient]
Synonym: Methylmaleic Anhydrides
Tree Number: T6.2.7.2
Tree Number: T6.3.5.10.2
database_cross_reference: MSH:D002949
database_cross_reference: NDFRT:N0000167138

Maleic Anhydrides
type: Class
subclass of: Anhydrides
subclass of: Furans
MCID: MC00007853
PMOID: PMO:00016229
Subclass_of: Anhydrides
Subclass_of: Furans
Synonym: 2,5 Furandiones
Synonym: 2,5-Furandiones
Synonym: Anhydrides, Maleic
Synonym: FURANDIONES 02 05
Synonym: Maleic Anhydrides [Chemical/Ingredient]
Tree Number: T6.2.7.3
Tree Number: T6.3.5.10.5
database_cross_reference: MSH:D008299
database_cross_reference: NDFRT:N0000167140

Phthalic Anhydrides
type: Class
subclass of: Anhydrides
MCID: MC00010178
PMOID: PMO:00016230
Subclass_of: Anhydrides
Synonym: Anhydrides, Phthalic
Synonym: Phthalic Anhydrides [Chemical/Ingredient]
Synonym: Phthalic anhydride
Tree Number: T6.2.7.4
database_cross_reference: LCH_NW:sh2011001273
database_cross_reference: MSH:D010796
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166644

Succinic Anhydrides
type: Class
subclass of: Anhydrides
MCID: MC00012340
PMOID: PMO:00016231
Subclass_of: Anhydrides
Synonym: Anhydrides, Succinic
Synonym: Succinic Anhydrides [Chemical/Ingredient]
Tree Number: T6.2.7.5
database_cross_reference: MSH:D013387
database_cross_reference: NDFRT:N0000166717

Polyanhydrides
type: Class
subclass of: Anhydrides
subclass of: Polymers
MCID: MC00516676
PMOID: PMO:00016232
Subclass_of: Anhydrides
Subclass_of: Polymers
Synonym: Polyanhydrides [Chemical/Ingredient]
Tree Number: T6.2.7.6
Tree Number: T6.5.2.16
database_cross_reference: MSH:D049388
database_cross_reference: NDFRT:N0000167476

Aza Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00001426
PMOID: PMO:00016233
Subclass_of: Organic Chemicals
Synonym: AZA CPDS
Synonym: Aza Compounds [Chemical/Ingredient]
Synonym: Compounds, Aza
Tree Number: T6.2.8
database_cross_reference: MSH:D001372
database_cross_reference: NDFRT:N0000011324

Azacitidine
type: Class
subclass of: Aza Compounds
MCID: MC00001428
PMOID: PMO:00016234
Subclass_of: Aza Compounds
Synonym: 1,3,5-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-
Synonym: 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Synonym: 4-Amino-1-beta-D-ribofuranosyl-S-triazin-2(1H)-one
Synonym: 5 AZC
Synonym: 5 Azacytidine
Synonym: 5 aza
Synonym: 5 azacytidine
Synonym: 5-AC
Synonym: 5-AZC
Synonym: 5-Aza-cytidine
Tree Number: T6.2.8.1
database_cross_reference: ATC:L01BC07
database_cross_reference: CHV:0000001634
database_cross_reference: CSP:2980-0131
database_cross_reference: DRUGBANK:DB00928
database_cross_reference: LCH_NW:sh2010007274
database_cross_reference: MEDCIN:258951
database_cross_reference: MEDCIN:40494
database_cross_reference: MMSL:18639
database_cross_reference: MMSL:205981
database_cross_reference: MMSL:d05293
database_cross_reference: MSH:D001374
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:M801H13NRU
database_cross_reference: NCI:C288
database_cross_reference: NCI_DTP:NSC0102816
database_cross_reference: NCI_FDA:M801H13NRU
database_cross_reference: NCI_NCI-GLOSS:CDR0000045177
database_cross_reference: NDDF:008661
database_cross_reference: NDFRT:N0000010550
database_cross_reference: NDFRT:N0000148852
database_cross_reference: PDQ:CDR0000039153
database_cross_reference: RXNORM:1251
database_cross_reference: SNM:E-8381
database_cross_reference: SNMI:C-78290
database_cross_reference: SNOMEDCT_US:412328000
database_cross_reference: SNOMEDCT_US:412329008
database_cross_reference: SNOMEDCT_US:88551000
database_cross_reference: VANDF:4021468

Azaguanine
type: Class
subclass of: Aza Compounds
MCID: MC00001429
PMOID: PMO:00016235
Subclass_of: Aza Compounds
Synonym: 5-Amino-1,4-dihydro-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
Synonym: 5-Amino-1H-v-triazolo(d)pyrimidin-7-ol
Synonym: 5-Amino-7-hydroxy-1H-v-triazolo(d)pyrimidine
Synonym: 7H-1,2,3-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-1,4-dihydro-
Synonym: 8 AG
Synonym: 8 Azaguanine
Synonym: 8-AZAGUANINE
Synonym: 8-Azaguanine
Synonym: 8-azaguanine
Synonym: Azaguanine [Chemical/Ingredient]
Tree Number: T6.2.8.2
database_cross_reference: CHV:0000001635
database_cross_reference: CSP:0312-9783
database_cross_reference: DRUGBANK:DB01667
database_cross_reference: MSH:D001375
database_cross_reference: NCI:C28788
database_cross_reference: NCI_FDA:Q150359I72
database_cross_reference: NDFRT:N0000166991

Azauridine
type: Class
subclass of: Aza Compounds
MCID: MC00001434
PMOID: PMO:00016236
Subclass_of: Aza Compounds
Synonym: 1,2,4-Triazine-3,5(2H,4H)-dione, 2-Beta-D-ribofuranosyl-
Synonym: 1,2,4-Triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl-
Synonym: 1,2,4-triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl
Synonym: 2-beta-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione
Synonym: 2-beta-D-ribofuranosyl-1,2,4-triazine-3,5(2H, 4H)-dione
Synonym: 2-beta-D-ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione
Synonym: 3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine riboside
Synonym: 6 Azauridine
Synonym: 6 azauridine
Synonym: 6-AZAURIDINE
Tree Number: T6.2.8.3
database_cross_reference: CSP:2109-1853
database_cross_reference: MSH:D001380
database_cross_reference: NCI:C1008
database_cross_reference: NCI:C291
database_cross_reference: NCI_DTP:NSC0032074
database_cross_reference: NCI_FDA:7BVB29RCPR
database_cross_reference: NDFRT:N0000170637
database_cross_reference: PDQ:CDR0000039158

Azabicyclo Compounds
type: Class
subclass of: Aza Compounds
subclass of: Bridged Bicyclo Compounds, Heterocyclic
MCID: MC00628677
PMOID: PMO:00016237
Subclass_of: Aza Compounds
Subclass_of: Bridged Bicyclo Compounds, Heterocyclic
Synonym: Azabicyclo Compounds [Chemical/Ingredient]
Synonym: Azabicyclo compound
Synonym: Azabicyclo compound (substance)
Tree Number: T6.2.8.4
Tree Number: T6.3.4.5.1
database_cross_reference: MSH:D053961
database_cross_reference: NDFRT:N0000178749
database_cross_reference: SNOMEDCT_US:441193001

Tropanes
type: Class
subclass of: Azabicyclo Compounds
subclass of: Alkaloids
subclass of: Heterocyclic Compounds, Bridged-Ring
MCID: MC00013149
PMOID: PMO:00016238
Subclass_of: Alkaloids
Subclass_of: Azabicyclo Compounds
Subclass_of: Heterocyclic Compounds, Bridged-Ring
Synonym: Tropane
Synonym: Tropane (substance)
Synonym: Tropane alkaloid
Synonym: Tropane alkaloid (substance)
Synonym: Tropanes [Chemical/Ingredient]
Synonym: tropane
Tree Number: T6.2.8.4.1
Tree Number: T6.3.3.20
Tree Number: T6.3.4.4
database_cross_reference: AOD:0000020540
database_cross_reference: CHV:0000018386
database_cross_reference: CSP:3002-2317
database_cross_reference: LCH_NW:sh91005153
database_cross_reference: MSH:D014326
database_cross_reference: NDFRT:N0000007744
database_cross_reference: SNOMEDCT_US:415755000
database_cross_reference: SNOMEDCT_US:419693009
database_cross_reference: SNOMEDCT_US:419961004

Atropine Derivatives
type: Class
subclass of: Tropanes
MCID: MC00001367
PMOID: PMO:00016239
Subclass_of: Tropanes
Synonym: Atropine Derivatives [Chemical/Ingredient]
Synonym: Atropines
Synonym: atropine derivatives
Synonym: atropine derivatives (medication)
Tree Number: T6.3.4.4.1
database_cross_reference: MEDCIN:41067
database_cross_reference: MSH:D001286
database_cross_reference: NDFRT:N0000007667

Benztropine
type: Class
subclass of: Tropanes
MCID: MC00001605
PMOID: PMO:00016243
Subclass_of: Tropanes
Synonym: 3-alpha-(diphenylmethoxy)tropane
Synonym: 3alpha-(Diphenylmethoxy)-1alphah,5alphah-tropane
Synonym: 3alpha-(Diphenylmethoxy)tropane
Synonym: 3alpha-Benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
Synonym: 3endo-benzhydryloxytropane
Synonym: 3α-(diphenylmethoxy)-1αH,5αH-tropane
Synonym: 3α-(diphenylmethoxy)tropane
Synonym: 3α-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
Synonym: 8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-
Synonym: BENZTROPINE
Tree Number: T6.3.3.20.2
Tree Number: T6.3.4.4.2
database_cross_reference: ATC:N04AC01
database_cross_reference: CCPSS:0059532
database_cross_reference: CHV:0000001802
database_cross_reference: CSP:3002-3254
database_cross_reference: DRUGBANK:DB00245
database_cross_reference: LNC:LP17858-9
database_cross_reference: LNC:MTHU019541
database_cross_reference: MEDCIN:340352
database_cross_reference: MMSL:d00175
database_cross_reference: MSH:D001590
database_cross_reference: MTHSPL:1NHL2J4X8K
database_cross_reference: NCI:C61649
database_cross_reference: NCI_FDA:1NHL2J4X8K
database_cross_reference: NDDF:004667
database_cross_reference: NDFRT:N0000007558
database_cross_reference: NDFRT:N0000147723
database_cross_reference: RCD:x01DT
database_cross_reference: RXNORM:1424
database_cross_reference: SNM:E-7553
database_cross_reference: SNMI:C-67510
database_cross_reference: SNOMEDCT_US:372846002
database_cross_reference: SNOMEDCT_US:77390008
database_cross_reference: USPMG:MTHU000593
database_cross_reference: VANDF:4019630

Cocaine
type: Class
subclass of: Tropanes
MCID: MC00132298
PMOID: PMO:00016244
Subclass_of: Tropanes
Synonym: (-)-Cocaine
Synonym: (−)-cocaine
Synonym: 2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylate benzoate (ester)
Synonym: Benzoylmethylecgonine
Synonym: Benzoylmethylecgonine (substance)
Synonym: Cocain
Synonym: Cocaina
Synonym: Cocaine Hydrochloride Top Sol 40mg/ml
Synonym: Cocaine Hydrochloride Topical Sol 10%
Synonym: Cocainum
Tree Number: T6.3.3.20.3
Tree Number: T6.3.4.4.3
database_cross_reference: DRUGBANK:DB00907
database_cross_reference: SNMI:C-6B242
database_cross_reference: SNOMEDCT_US:96270004

Crack Cocaine
type: Class
subclass of: PMO:00024495
MCID: MC00043181
PMOID: PMO:00016245
Subclass_of: Street Drugs
Synonym: COCAINE CRACK
Synonym: Cocaine freebase
Synonym: Cocaine freebase (substance)
Synonym: Cocaine, Crack
Synonym: Crack
Synonym: Crack Cocaine [Chemical/Ingredient]
Synonym: Crack cocaine
Synonym: Rocks - cocaine
Synonym: cocaine crack
Synonym: crack cocaine
Tree Number: T6.15.13.1
database_cross_reference: AOD:0000000859
database_cross_reference: AOD:0000021395
database_cross_reference: CCPSS:0055295
database_cross_reference: CHV:0000015471
database_cross_reference: CSP:4000-0157
database_cross_reference: MEDLINEPLUS:193
database_cross_reference: MSH:D016578
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C105553
database_cross_reference: NDFRT:N0000166993
database_cross_reference: PSY:12305
database_cross_reference: RCD:Ub18U
database_cross_reference: SNOMEDCT_US:229003004

Nortropanes
type: Class
subclass of: Tropanes
MCID: MC00009016
PMOID: PMO:00016246
Subclass_of: Tropanes
Synonym: Nortropanes [Chemical/Ingredient]
Tree Number: T6.3.4.4.4
database_cross_reference: MSH:D009662
database_cross_reference: NDFRT:N0000166992

Scopolamine Derivatives
type: Class
subclass of: Tropanes
MCID: MC00011672
PMOID: PMO:00016247
Subclass_of: Tropanes
Synonym: Derivatives, Scopolamine
Synonym: Scopolamine Derivatives [Chemical/Ingredient]
Synonym: Scopolamines
Synonym: scopolamine derivative
Tree Number: T6.3.3.20.4
Tree Number: T6.3.4.4.5
database_cross_reference: AOD:0000020542
database_cross_reference: MSH:D012602
database_cross_reference: NDFRT:N0000007907

Granisetron
type: Class
subclass of: Azabicyclo Compounds
MCID: MC00028005
PMOID: PMO:00016251
Subclass_of: Azabicyclo Compounds
Synonym: 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide
Synonym: 1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide
Synonym: 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, endo-
Synonym: Apo-granisetron
Synonym: GRAN
Synonym: GRANISETRON
Synonym: Gran
Synonym: Granisetron (product)
Synonym: Granisetron (substance)
Synonym: Granisetron Hydrochloride Injection
Tree Number: T6.2.8.4.2
database_cross_reference: ATC:A04AA02
database_cross_reference: CHV:0000014123
database_cross_reference: DRUGBANK:DB00099
database_cross_reference: DRUGBANK:DB00889
database_cross_reference: MMSL:25895
database_cross_reference: MMSL:d03171
database_cross_reference: MSH:D017829
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:WZG3J2MCOL
database_cross_reference: NCI:C62031
database_cross_reference: NCI:C80377
database_cross_reference: NCI_FDA:WZG3J2MCOL
database_cross_reference: NCI_NCI-GLOSS:CDR0000045432
database_cross_reference: NDDF:003975
database_cross_reference: NDFRT:N0000007467
database_cross_reference: NDFRT:N0000021915
database_cross_reference: PDQ:CDR0000042236
database_cross_reference: RCD:x019d
database_cross_reference: RXNORM:26237
database_cross_reference: SNOMEDCT_US:108424001
database_cross_reference: SNOMEDCT_US:372489005
database_cross_reference: USPMG:MTHU000350
database_cross_reference: VANDF:4023910

Azo Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00001444
PMOID: PMO:00016252
Subclass_of: Organic Chemicals
Synonym: AZO CPDS
Synonym: Azo Compounds [Chemical/Ingredient]
Synonym: Azo compounds
Synonym: Compounds, Azo
Synonym: azo compound
Tree Number: T6.2.10
database_cross_reference: CSP:0316-3497
database_cross_reference: LCH:U000461
database_cross_reference: LCH_NW:sh85010652
database_cross_reference: MSH:D001391
database_cross_reference: NDFRT:N0000007882

Amaranth Dye
type: Class
subclass of: Azo Compounds
MCID: MC00000695
PMOID: PMO:00016253
Subclass_of: Azo Compounds
Synonym: 1-(4-sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic Acid Trisodium Salt
Synonym: 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodium salt
Synonym: 3-hydroxy-4-(2-(4-sulfo-1-naphthalenyl)diazenyl)-2,7-naphthalenedisulfonic Acid Sodium Salt (1:3)
Synonym: AMARANTH
Synonym: Amaranth
Synonym: Amaranth (product)
Synonym: Amaranth (substance)
Synonym: Amaranth Dye [Chemical/Ingredient]
Synonym: Amaranth dye
Synonym: Amaranths
Tree Number: T6.2.10.1
database_cross_reference: CHV:0000000970
database_cross_reference: LCH_NW:sh85004105
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000548
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:37RBV3X49K
database_cross_reference: NCI:C71677
database_cross_reference: NCI_FDA:37RBV3X49K
database_cross_reference: NDDF:002623
database_cross_reference: NDFRT:N0000167385
database_cross_reference: RCD:Ub0db
database_cross_reference: RXNORM:1433189
database_cross_reference: SNM:E-6287
database_cross_reference: SNMI:C-22831
database_cross_reference: SNOMEDCT_US:2159007
database_cross_reference: SNOMEDCT_US:420963005
database_cross_reference: SNOMEDCT_US:422210001

Amido Black
type: Class
subclass of: Azo Compounds
MCID: MC00000718
PMOID: PMO:00016254
Subclass_of: Azo Compounds
Synonym: 2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-3-((4-nitrophenyl)azo)-6-(phenylazo)-, disodium salt
Synonym: Amido Black [Chemical/Ingredient]
Synonym: Black, Amido
Tree Number: T6.2.10.2
database_cross_reference: MSH:D000580
database_cross_reference: NDFRT:N0000167388

Arsenazo III
type: Class
subclass of: Arsenicals
subclass of: Azo Compounds
MCID: MC00001244
PMOID: PMO:00016255
Subclass_of: Arsenicals
Subclass_of: Azo Compounds
Synonym: 2,7-Naphthalenedisulfonic acid, 3,6-bis((2-arsonophenyl)azo)-4,5-dihydroxy-
Synonym: ARSENAZO 03
Synonym: Arsenazo III [Chemical/Ingredient]
Tree Number: T6.2.10.3
Tree Number: T6.2.28.5.4
database_cross_reference: MSH:D001150
database_cross_reference: NDFRT:N0000166775

Azoxymethane
type: Class
subclass of: Azo Compounds
MCID: MC00001448
PMOID: PMO:00016256
Subclass_of: Azo Compounds
Synonym: AOM
Synonym: AZOXYMETHANE
Synonym: Azoxymethane [Chemical/Ingredient]
Synonym: Diazene, dimethyl-, 1-oxide
Synonym: azoxymethane
Tree Number: T6.2.10.4
database_cross_reference: MSH:D001397
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C294
database_cross_reference: NCI_FDA:MO0N1J0SEN
database_cross_reference: NCI_NCI-GLOSS:CDR0000367457
database_cross_reference: NDFRT:N0000166310

Cycasin
type: Class
subclass of: Azoxymethane
MCID: MC00003392
PMOID: PMO:00016257
Subclass_of: Azoxymethane
Synonym: (Methyl-ONN-azoxy)methyl beta-D-Glucopyranoside
Synonym: Cycasin [Chemical/Ingredient]
Synonym: Glucuronate, Methylazoxymethanol
Synonym: Methylazoxymethanol Glucuronate
Synonym: Methylazoxymethanol beta D Glucoside
Synonym: Methylazoxymethanol beta-D-Glucoside
Synonym: beta-D-Glucopyranoside, (methyl-ONN-azoxy)methyl
Synonym: beta-D-Glucoside, Methylazoxymethanol
Synonym: cycasin
Tree Number: T6.2.10.4.1
database_cross_reference: CSP:0316-3497
database_cross_reference: MSH:D003492
database_cross_reference: NDFRT:N0000166312

Methylazoxymethanol Acetate
type: Class
subclass of: Azoxymethane
MCID: MC00008214
PMOID: PMO:00016258
Subclass_of: Azoxymethane
Synonym: (Methyl-ONN-azoxy)methanol Acetate
Synonym: Acetate, Methylazoxymethanol
Synonym: Methanol, (methyl-ONN-azoxy)-, acetate (ester)
Synonym: Methylazoxymethanol Acetate [Chemical/Ingredient]
Tree Number: T6.2.10.4.2
database_cross_reference: MSH:D008746
database_cross_reference: NDFRT:N0000166311

Diamide
type: Class
subclass of: Azo Compounds
MCID: MC00003812
PMOID: PMO:00016259
Subclass_of: Azo Compounds
Synonym: Acid Bisdimethylamide, Diazodicarboxylic
Synonym: Bisdimethylamide, Diazodicarboxylic Acid
Synonym: Diamide [Chemical/Ingredient]
Synonym: Diazenedicarboxamide, tetramethyl-
Synonym: Diazodicarboxylic Acid Bis(N,N-dimethyl)amide
Synonym: Diazodicarboxylic Acid Bisdimethylamide
Synonym: Dizene Dicarboxylic Acid Bis(N,N-dimethylamide)
Synonym: Dizenedicarboxylic Acid Bis(N,N-dimethylamide)
Synonym: Tetramethylazoformamide
Synonym: diamide
Tree Number: T6.2.10.5
database_cross_reference: CHV:0000003860
database_cross_reference: MSH:D003958
database_cross_reference: NDFRT:N0000166313

Diazonium Compounds
type: Class
subclass of: Azo Compounds
MCID: MC00003833
PMOID: PMO:00016260
Subclass_of: Azo Compounds
Synonym: Compounds, Diazonium
Synonym: DIAZONIUM CPDS
Synonym: Diazonium Compounds [Chemical/Ingredient]
Tree Number: T6.2.10.6
database_cross_reference: MSH:D003979
database_cross_reference: NCI:C426
database_cross_reference: NDFRT:N0000166308

Diazomethane
type: Class
subclass of: Diazonium Compounds
MCID: MC00003832
PMOID: PMO:00016261
Subclass_of: Diazonium Compounds
Synonym: Diazirine
Synonym: Diazomethane (substance)
Synonym: Diazomethane [Chemical/Ingredient]
Synonym: Methane, diazo-
Tree Number: T6.2.10.6.1
database_cross_reference: LCH:U001382
database_cross_reference: LCH_NW:sh85037642
database_cross_reference: LNC:MTHU017584
database_cross_reference: MSH:D003978
database_cross_reference: NDFRT:N0000166309
database_cross_reference: SNMI:C-20515
database_cross_reference: SNOMEDCT_US:46601006

Diazooxonorleucine
type: Class
subclass of: Azo Compounds
MCID: MC00003834
PMOID: PMO:00016262
Subclass_of: Azo Compounds
Synonym: 6 Diazo 5 oxo L norleucine
Synonym: 6-DIAZO-5-OXO-L-NORLEUCINE
Synonym: 6-Diazo-5-oxo-L-norleucine
Synonym: 6-diazo-5-oxo-L-norleucine
Synonym: 6-diazo-5-oxo-norleucine
Synonym: DON
Synonym: Diazooxonorleucine [Chemical/Ingredient]
Synonym: Norleucine, 6-diazo-5-oxo-
Synonym: diazooxonorleucine
Tree Number: T6.2.10.7
database_cross_reference: MSH:D003980
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C427
database_cross_reference: NCI_DTP:NSC0007365
database_cross_reference: NCI_DTP:NSC0083700
database_cross_reference: NDFRT:N0000170209
database_cross_reference: PDQ:CDR0000039224

Dithizone
type: Class
subclass of: Azo Compounds
subclass of: Phenylhydrazines
MCID: MC00004080
PMOID: PMO:00016263
Subclass_of: Azo Compounds
Subclass_of: Phenylhydrazines
Synonym: Diazenecarbothioic acid, phenyl-, 2-phenylhydrazide
Synonym: Diphenylthiocarbazone
Synonym: Dithizon
Synonym: Dithizone [Chemical/Ingredient]
Tree Number: T6.2.10.8
Tree Number: T6.2.16.8.1
database_cross_reference: MSH:D004230
database_cross_reference: NDFRT:N0000166557

Evans Blue
type: Class
subclass of: Azo Compounds
MCID: MC00004838
PMOID: PMO:00016264
Subclass_of: Azo Compounds
Synonym: 1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(4-amino-5-hydroxy)-, tetrasodium salt
Synonym: Azovan Blue
Synonym: Blue, Azovan
Synonym: Blue, Evan's
Synonym: Blue, Evans
Synonym: Diazol pure blue
Synonym: Direct blue 58
Synonym: EVANS BLUE
Synonym: Evan Blue
Synonym: Evan's Blue
Tree Number: T6.2.10.9
database_cross_reference: CHV:0000004746
database_cross_reference: LCH:U001697
database_cross_reference: LCH_NW:sh85045947
database_cross_reference: MSH:D005070
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C65605
database_cross_reference: NCI_FDA:45PG892GO1
database_cross_reference: NDDF:002040
database_cross_reference: NDDF:002625
database_cross_reference: NDFRT:N0000006872
database_cross_reference: NDFRT:N0000147338
database_cross_reference: RXNORM:4191
database_cross_reference: SNM:E-8103
database_cross_reference: SNMI:C-22854
database_cross_reference: SNOMEDCT_US:22931006
database_cross_reference: VANDF:4019071

Formazans
type: Class
subclass of: Azo Compounds
MCID: MC00005269
PMOID: PMO:00016265
Subclass_of: Azo Compounds
Synonym: Formazans [Chemical/Ingredient]
Tree Number: T6.2.10.10
database_cross_reference: MSH:D005562
database_cross_reference: NDFRT:N0000166307

o-Aminoazotoluene
type: Class
subclass of: Azo Compounds
MCID: MC00009082
PMOID: PMO:00016266
Subclass_of: Azo Compounds
Synonym: 4-o-Tolylazo-o-Toluidine
Synonym: AMINOAZOTOLUENE O
Synonym: Benzenamine, 2-methyl-4-((2-methylphenyl)azo)-
Synonym: o Aminoazotoluene
Synonym: o-Aminoazotoluene [Chemical/Ingredient]
Synonym: ortho Aminoazotoluene
Synonym: ortho-Aminoazotoluene
Tree Number: T6.2.10.11
database_cross_reference: MSH:D009762
database_cross_reference: NCI:C29845
database_cross_reference: NDFRT:N0000166306

p-Azobenzenearsonate
type: Class
subclass of: Arsenicals
subclass of: Azo Compounds
MCID: MC00009608
PMOID: PMO:00016267
Subclass_of: Arsenicals
Subclass_of: Azo Compounds
Synonym: AZOBENZENEARSONATE P
Synonym: Arsonic acid, (azodi-4,1-phenylene)bis-
Synonym: p Azobenzenearsonate
Synonym: p-Azobenzenearsonate [Chemical/Ingredient]
Synonym: para Azobenzenearsonate
Synonym: para-Azobenzenearsonate
Tree Number: T6.2.10.13
Tree Number: T6.2.28.5.8
database_cross_reference: MSH:D010132
database_cross_reference: NDFRT:N0000171185

Tartrazine
type: Class
subclass of: Azo Compounds
MCID: MC00012558
PMOID: PMO:00016268
Subclass_of: Azo Compounds
Synonym: 1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-((4-sulfophenyl)azo)-, trisodium salt
Synonym: Acid yellow 23
Synonym: F D & C YELLOW #5
Synonym: F D & C Yellow #5
Synonym: FD & C Yellow No. 5
Synonym: FD and C no.5 (tartrazine)
Synonym: FD and C yellow 5
Synonym: FD&C YELLOW NO. 5
Synonym: FD&C YELLOW No. 5
Synonym: FD&C Yellow #5
Tree Number: T6.2.10.14
database_cross_reference: CHV:0000012040
database_cross_reference: LNC:LP62285-9
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D013645
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:I753WB2F1M
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C71681
database_cross_reference: NCI_FDA:I753WB2F1M
database_cross_reference: NDDF:008923
database_cross_reference: NDFRT:N0000007078
database_cross_reference: NDFRT:N0000022452
database_cross_reference: NDFRT:N0000022694
database_cross_reference: RCD:Ub0dW
database_cross_reference: RXNORM:1305578
database_cross_reference: SNM:E-6299
database_cross_reference: SNMI:C-22844
database_cross_reference: SNOMEDCT_US:21592006
database_cross_reference: SNOMEDCT_US:419479008
database_cross_reference: VANDF:4018441
database_cross_reference: VANDF:4020156

Trypan Blue
type: Class
subclass of: Azo Compounds
MCID: MC00013163
PMOID: PMO:00016269
Subclass_of: Azo Compounds
Synonym: 2,7-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(5-amino-4-hydroxy-), tetrasodium salt
Synonym: Benzamine Blue
Synonym: Blue, Diamine
Synonym: Blue, Niagara
Synonym: Blue, Trypan
Synonym: C34H28N6O14S4
Synonym: Congo blue 3B
Synonym: D.O.R.C. Vision Blue
Synonym: Diamine Blue
Synonym: Direct blue 14
Tree Number: T6.2.10.15
database_cross_reference: CHV:0000012606
database_cross_reference: CSP:0316-5263
database_cross_reference: DRUGBANK:DB09158
database_cross_reference: LCH:U004798
database_cross_reference: LCH_NW:sh85138290
database_cross_reference: MMSL:20134
database_cross_reference: MSH:D014343
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:I2ZWO3LS3M
database_cross_reference: NCI:C910
database_cross_reference: NCI_DCP:03387
database_cross_reference: NCI_DTP:NSC0011247
database_cross_reference: NCI_FDA:I2ZWO3LS3M
database_cross_reference: NDDF:005491
database_cross_reference: NDFRT:N0000023102
database_cross_reference: NDFRT:N0000167386
database_cross_reference: RXNORM:10878
database_cross_reference: SNM:E-8113
database_cross_reference: SNMI:C-22853
database_cross_reference: SNOMEDCT_US:408741002
database_cross_reference: SNOMEDCT_US:417560000
database_cross_reference: SNOMEDCT_US:60441008
database_cross_reference: VANDF:4024919

Carboxylic Acids
type: Class
subclass of: Organic Chemicals
MCID: MC00002260
PMOID: PMO:00016271
Subclass_of: Organic Chemicals
Synonym: Acids, Carboxylic
Synonym: Carboxylic Acids [Chemical/Ingredient]
Synonym: Carboxylic acid
Synonym: Carboxylic acid (substance)
Synonym: Carboxylic acid, NOS
Synonym: Carboxylic acids
Synonym: carboxylic acid
Synonym: carboxylic acids
Tree Number: T6.2.12
database_cross_reference: AOD:0000019860
database_cross_reference: CHV:0000002409
database_cross_reference: LCH:U000791
database_cross_reference: LCH_NW:sh85020144
database_cross_reference: MSH:D002264
database_cross_reference: NCI:C345
database_cross_reference: NDFRT:N0000008137
database_cross_reference: SNMI:C-21600
database_cross_reference: SNOMEDCT_US:42907009

Acids, Acyclic
type: Class
subclass of: Carboxylic Acids
MCID: MC00000245
PMOID: PMO:00016272
Subclass_of: Carboxylic Acids
Synonym: Acids, Acyclic [Chemical/Ingredient]
Synonym: Acyclic Acids
Tree Number: T6.2.12.1
database_cross_reference: MSH:D000144
database_cross_reference: NDFRT:N0000007627

Acetates
type: Class
subclass of: Acids, Acyclic
subclass of: PMO:00021158
MCID: MC00000177
PMOID: PMO:00016273
Subclass_of: Acids, Acyclic
Subclass_of: Fatty Acids, Volatile
Synonym: Acetates [Chemical/Ingredient]
Synonym: acetates
Tree Number: T6.2.12.1.1
Tree Number: T6.9.3.6.1
database_cross_reference: CHV:0000000603
database_cross_reference: LCH:U000022
database_cross_reference: LCH_NW:sh85000457
database_cross_reference: MSH:D000085
database_cross_reference: MTH:U001658
database_cross_reference: NDFRT:N0000007362

Glycolates
type: Class
subclass of: Hydroxy Acids
MCID: MC00005754
PMOID: PMO:00016276
Subclass_of: Hydroxy Acids
Synonym: 2 Hydroxyacetates
Synonym: 2-Hydroxyacetates
Synonym: Glycolates [Chemical/Ingredient]
Synonym: Hydroxyacetates
Synonym: glycolate
Synonym: glycolated
Tree Number: T6.2.12.6.2
database_cross_reference: CHV:0000005617
database_cross_reference: CSP:1129-2824
database_cross_reference: MSH:D006016
database_cross_reference: MTH:U001963
database_cross_reference: NDFRT:N0000007885

Ticrynafen
type: Class
subclass of: Thiophenes
MCID: MC00012857
PMOID: PMO:00016282
Subclass_of: Thiophenes
Synonym: (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid
Synonym: (2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid
Synonym: (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid
Synonym: 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure
Synonym: 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid
Synonym: Acetic acid, (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-
Synonym: Acid, Thienylic
Synonym: Acid, Tienilic
Synonym: Acide tienilique
Synonym: Acido tienilico
Tree Number: T6.2.32.22.12
Tree Number: T6.3.5.25.11
database_cross_reference: ATC:C03CC02
database_cross_reference: CHV:0000012285
database_cross_reference: DRUGBANK:DB04831
database_cross_reference: MSH:D013989
database_cross_reference: NDDF:002311
database_cross_reference: NDFRT:N0000167168
database_cross_reference: SNM:E-7658
database_cross_reference: SNMI:C-812C5
database_cross_reference: SNOMEDCT_US:64029000

Phosphonoacetic Acid
type: Class
subclass of: Organophosphonates
MCID: MC00010139
PMOID: PMO:00016289
Subclass_of: Organophosphonates
Synonym: Acetic acid, phosphono-
Synonym: Carboxymethanephosphonic Acid
Synonym: Fosfonet
Synonym: PHOSPHONOACETIC ACID
Synonym: PPA
Synonym: Phosphonacetic Acid
Synonym: Phosphonacetic acid
Synonym: Phosphonacetic acid (substance)
Synonym: Phosphonoacetic Acid [Chemical/Ingredient]
Synonym: fosfonet
Tree Number: T6.2.29.6.6
database_cross_reference: ATC:J05AD02
database_cross_reference: DRUGBANK:DB02823
database_cross_reference: MSH:D010746
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84056
database_cross_reference: NCI_FDA:N919E46723
database_cross_reference: NDFRT:N0000007721
database_cross_reference: SNM:E-7357
database_cross_reference: SNMI:C-55B80
database_cross_reference: SNOMEDCT_US:84317008

Thioglycolates
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00012733
PMOID: PMO:00016291
Subclass_of: Sulfhydryl Compounds
Synonym: Thioglycolate
Synonym: Thioglycolate (substance)
Synonym: Thioglycolates [Chemical/Ingredient]
Synonym: Thioglycollates
Synonym: thioglycolate
Synonym: thioglycollate
Synonym: thioglycollates
Tree Number: T6.2.32.6.10
database_cross_reference: CHV:0000012187
database_cross_reference: MSH:D013864
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166693
database_cross_reference: SNOMEDCT_US:425526007

Acrylates
type: Class
subclass of: Acids, Acyclic
MCID: MC00000281
PMOID: PMO:00016298
Subclass_of: Acids, Acyclic
Synonym: Acrylates [Chemical/Ingredient]
Synonym: acrylates
Tree Number: T6.2.12.1.2
database_cross_reference: CHV:0000000662
database_cross_reference: LCH_NW:sh91004852
database_cross_reference: MSH:D000179
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000006515
database_cross_reference: RCD:XM0Ei

Cyanoacrylates
type: Class
subclass of: Nitriles
subclass of: Polymers
subclass of: PMO:00024440
MCID: MC00003388
PMOID: PMO:00016299
Subclass_of: Nitriles
Subclass_of: Polymers
Subclass_of: Tissue Adhesives
Synonym: Cyanoacrylate
Synonym: Cyanoacrylate (substance)
Synonym: Cyanoacrylate, NOS
Synonym: Cyanoacrylates [Chemical/Ingredient]
Synonym: cyanoacrylate
Synonym: cyanoacrylates
Tree Number: T6.14.11.1
Tree Number: T6.14.9.3
Tree Number: T6.2.23.8
Tree Number: T6.5.2.5
database_cross_reference: CHV:0000003515
database_cross_reference: LCH:U001227
database_cross_reference: LCH_NW:sh86004636
database_cross_reference: MSH:D003487
database_cross_reference: NDFRT:N0000171530
database_cross_reference: RCD:X79B1
database_cross_reference: SNM:E-5304
database_cross_reference: SNMI:C-2A200
database_cross_reference: SNOMEDCT_US:79549001

Bucrylate
type: Class
subclass of: Cyanoacrylates
MCID: MC00001998
PMOID: PMO:00016300
Subclass_of: Cyanoacrylates
Synonym: 2-Propenoic acid, 2-cyano-, 2-methylpropyl ester
Synonym: Bucrilate
Synonym: Bucrylate [Chemical/Ingredient]
Synonym: Cyanoacrylate, Isobutyl
Synonym: Isobutyl 2 cyanoacrylate
Synonym: Isobutyl Cyanoacrylate
Synonym: Isobutyl alpha Cyanoacrylate
Synonym: Isobutyl alpha-Cyanoacrylate
Synonym: Isobutyl-2-cyanoacrylate
Synonym: Isobutylcyanoacrylate
Tree Number: T6.2.23.8.1
database_cross_reference: MSH:D002015
database_cross_reference: NDFRT:N0000171532

Enbucrilate
type: Class
subclass of: Cyanoacrylates
MCID: MC00004403
PMOID: PMO:00016301
Subclass_of: Cyanoacrylates
Synonym: 2 Cyanobutylacrylate
Synonym: 2-Cyanacrylates, Butyl
Synonym: 2-Cyanobutylacrylate
Synonym: 2-Cyanobutylacrylates
Synonym: 2-Propenoic acid, 2-cyano-, butyl ester
Synonym: Butyl 2 Cyanacrylate
Synonym: Butyl 2-Cyanacrylate
Synonym: Butyl 2-Cyanacrylates
Synonym: Butyl 2-cyanoacrylate
Synonym: Butyl-2-cyanoacrylate
Tree Number: T6.14.11.1.1
Tree Number: T6.14.9.3.1
Tree Number: T6.2.23.8.2
Tree Number: T6.5.2.5.1
database_cross_reference: DRUGBANK:DB12358
database_cross_reference: MSH:D004659
database_cross_reference: NDDF:004461
database_cross_reference: NDFRT:N0000171531
database_cross_reference: RCD:x0045
database_cross_reference: SNOMEDCT_US:346412004
database_cross_reference: SNOMEDCT_US:396041002
database_cross_reference: SNOMEDCT_US:407747001
database_cross_reference: SNOMEDCT_US:409102000

Butyrates
type: Class
subclass of: Acids, Acyclic
subclass of: PMO:00021158
MCID: MC00002060
PMOID: PMO:00016310
Subclass_of: Acids, Acyclic
Subclass_of: Fatty Acids, Volatile
Synonym: Butyrate
Synonym: Butyrates [Chemical/Ingredient]
Synonym: butyrate
Tree Number: T6.2.12.1.3
Tree Number: T6.9.3.6.2
database_cross_reference: CHV:0000002260
database_cross_reference: CSP:1129-2668
database_cross_reference: DRUGBANK:DB03568
database_cross_reference: MSH:D002087
database_cross_reference: MTH:U001768
database_cross_reference: NDFRT:N0000007859

Aminobutyrates
type: Class
subclass of: PMO:00021256
MCID: MC00638159
PMOID: PMO:00016312
Subclass_of: Amino Acids
Synonym: Aminobutyrates [Chemical/Ingredient]
Tree Number: T6.10.1.9
database_cross_reference: LNC:LP31651-0
database_cross_reference: MSH:D000613
database_cross_reference: NDFRT:N0000185670

gamma-Aminobutyric Acid
type: Class
subclass of: Aminobutyrates
MCID: MC00005370
PMOID: PMO:00016313
Subclass_of: Aminobutyrates
Synonym: .GAMMA.-AMINOBUTYRIC ACID
Synonym: .gamma.-aminobutyric Acid
Synonym: .gamma.-aminobutyric acid
Synonym: 4 Aminobutanoic Acid
Synonym: 4 Aminobutyric Acid
Synonym: 4-Aminobutanoic Acid
Synonym: 4-Aminobutyric Acid
Synonym: 4-aminobutanoic acid
Synonym: 4-aminobutyric acid
Synonym: 4Abu
Tree Number: T6.10.1.9.2
database_cross_reference: AOD:0000018838
database_cross_reference: AOD:0000028807
database_cross_reference: CHV:0000005309
database_cross_reference: CSP:0124-2160
database_cross_reference: DRUGBANK:DB02530
database_cross_reference: FMA:84786
database_cross_reference: LCH:U001896
database_cross_reference: LCH_NW:sh85052647
database_cross_reference: MSH:D005680
database_cross_reference: MTHSPL:2ACZ6IPC6I
database_cross_reference: NCI:C80523
database_cross_reference: NCI_FDA:2ACZ6IPC6I
database_cross_reference: NDDF:006466
database_cross_reference: NDFRT:N0000007783
database_cross_reference: NDFRT:N0000191506
database_cross_reference: PSY:20585
database_cross_reference: RCD:X807G
database_cross_reference: RXNORM:4617
database_cross_reference: SNOMEDCT_US:259100002
database_cross_reference: VANDF:4034308

Hydroxybutyrates
type: Class
subclass of: Hydroxy Acids
MCID: MC00006488
PMOID: PMO:00016318
Subclass_of: Hydroxy Acids
Synonym: Hydroxybutyrate
Synonym: Hydroxybutyrates [Chemical/Ingredient]
Synonym: hydroxybutyrate
Tree Number: T6.2.12.6.4
database_cross_reference: AOD:0000019887
database_cross_reference: CHV:0000006375
database_cross_reference: LNC:LP28775-2
database_cross_reference: LNC:LP31650-2
database_cross_reference: MSH:D006885
database_cross_reference: NDFRT:N0000011469

3-Hydroxybutyric Acid
type: Class
subclass of: Ketone Bodies
MCID: MC00016779
PMOID: PMO:00016320
Subclass_of: Ketone Bodies
Synonym: (+ -)-3-Hydroxybutyric Acid
Synonym: 3 Hydroxybutyric Acid
Synonym: 3-Hydroxybutyric Acid [Chemical/Ingredient]
Synonym: Butanoic acid, 3-hydroxy-
Synonym: HYDROXYBUTYRIC ACID A 003
Synonym: beta Hydroxybutyric Acid
Synonym: beta hydroxybutyric acid
Synonym: beta-Hydroxybutyric Acid
Synonym: beta-hydroxybutyric acid
Tree Number: T6.2.20.9.2
database_cross_reference: CHV:0000013360
database_cross_reference: MSH:D020155
database_cross_reference: NDFRT:N0000011470

Aminoisobutyric Acids
type: Class
subclass of: Aminobutyrates
subclass of: PMO:00021261
MCID: MC00000763
PMOID: PMO:00016323
Subclass_of: Amino Acids, Branched-Chain
Subclass_of: Aminobutyrates
Synonym: Acids, Aminoisobutyric
Synonym: Aminoisobutyric Acids [Chemical/Ingredient]
Tree Number: T6.10.1.3.1
Tree Number: T6.10.1.9.1
database_cross_reference: MSH:D000621
database_cross_reference: NDFRT:N0000170279

Fibric Acids
type: Class
subclass of: Phenyl Ethers
MCID: MC00797932
PMOID: PMO:00016324
Subclass_of: Phenyl Ethers
Synonym: 2 Phenoxy 2 Methylpropionic Acid Derivatives
Synonym: 2 Phenoxy Isobutyric Acids
Synonym: 2-Phenoxy Isobutyric Acids
Synonym: 2-Phenoxy-2-Methylpropionic Acid Derivatives
Synonym: Acid Derivatives, Fibric
Synonym: Fibric Acid Derivatives
Synonym: Fibric Acids [Chemical/Ingredient]
Synonym: Isobutyric Acids, 2-Phenoxy
Synonym: Methyl 2 Phenoxypropanoic Acid Derivatives
Synonym: Methyl-2-Phenoxypropanoic Acid Derivatives
Tree Number: T6.2.14.7.7
database_cross_reference: MSH:D058607
database_cross_reference: NDFRT:N0000182116

Fenofibrate
type: Class
subclass of: Benzophenones
MCID: MC00010642
PMOID: PMO:00016328
Subclass_of: Benzophenones
Synonym: 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
Synonym: Apo-feno-micro Capsules
Synonym: Apo-feno-super
Synonym: Ava-fenofibrate Micro
Synonym: Dom-fenofibrate Micro
Synonym: Dom-fenofibrate Supra
Synonym: FENOFIBRATE
Synonym: FNF
Synonym: Feno-micro-200
Synonym: Fenofibrate (product)
Tree Number: T6.2.20.3.2
database_cross_reference: ATC:C10AB05
database_cross_reference: CHV:0000010140
database_cross_reference: DRUGBANK:DB01039
database_cross_reference: LCH_NW:sh95008680
database_cross_reference: LNC:LP171398-3
database_cross_reference: MEDCIN:133035
database_cross_reference: MMSL:12032
database_cross_reference: MMSL:44688
database_cross_reference: MMSL:d04286
database_cross_reference: MSH:D011345
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:U202363UOS
database_cross_reference: NCI:C29047
database_cross_reference: NCI_FDA:U202363UOS
database_cross_reference: NCI_NCI-GLOSS:CDR0000518309
database_cross_reference: NDDF:003789
database_cross_reference: NDFRT:N0000005823
database_cross_reference: NDFRT:N0000148554
database_cross_reference: PDQ:CDR0000459750
database_cross_reference: RCD:bxc..
database_cross_reference: RXNORM:8703
database_cross_reference: SNOMEDCT_US:108603001
database_cross_reference: SNOMEDCT_US:386879008
database_cross_reference: USPMG:MTHU000998
database_cross_reference: VANDF:4021098

Caproates
type: Class
subclass of: Acids, Acyclic
subclass of: PMO:00021158
MCID: MC00002193
PMOID: PMO:00016330
Subclass_of: Acids, Acyclic
Subclass_of: Fatty Acids, Volatile
Synonym: Caproates [Chemical/Ingredient]
Synonym: Hexanoates
Tree Number: T6.2.12.1.4
Tree Number: T6.9.3.6.3
database_cross_reference: MSH:D002208
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008121

Aminocaproates
type: Class
subclass of: PMO:00021256
MCID: MC00943926
PMOID: PMO:00016331
Subclass_of: Amino Acids
Synonym: Aminocaproates [Chemical/Ingredient]
Synonym: Aminohexanoates
Tree Number: T6.10.1.10
database_cross_reference: MSH:D000614
database_cross_reference: NDFRT:N0000189486

Aminocaproic Acid
type: Class
subclass of: Aminocaproates
MCID: MC00000097
PMOID: PMO:00016332
Subclass_of: Aminocaproates
Synonym: 6 Aminocaproic Acid
Synonym: 6 Aminohexanoic Acid
Synonym: 6-Aminocaproic Acid
Synonym: 6-Aminocaproic acid
Synonym: 6-Aminohexanoic Acid
Synonym: 6-aminohexanoic acid
Synonym: AMINOCAPROIC
Synonym: AMINOCAPROIC ACID
Synonym: AMINOCAPROIC ACID 06
Synonym: AMINOHEXANOIC ACID 06
Tree Number: T6.10.1.10.2
database_cross_reference: ATC:B02AA01
database_cross_reference: CHV:0000000519
database_cross_reference: DRUGBANK:DB00513
database_cross_reference: MEDCIN:40935
database_cross_reference: MMSL:4169
database_cross_reference: MMSL:4207
database_cross_reference: MMSL:d00528
database_cross_reference: MSH:D015119
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:U6F3787206
database_cross_reference: NCI:C47391
database_cross_reference: NCI_DCP:01191
database_cross_reference: NCI_FDA:U6F3787206
database_cross_reference: NDDF:002072
database_cross_reference: NDFRT:N0000146262
database_cross_reference: NDFRT:N0000170207
database_cross_reference: RXNORM:99
database_cross_reference: SNM:E-8457
database_cross_reference: SNMI:C-A7010
database_cross_reference: SNOMEDCT_US:360246003
database_cross_reference: SNOMEDCT_US:59882007
database_cross_reference: VANDF:4017911

Mycophenolic Acid
type: Class
subclass of: PMO:00021087
MCID: MC00008522
PMOID: PMO:00016333
Subclass_of: Fatty Acids
Synonym: (e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Synonym: -Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)-
Synonym: 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)-
Synonym: 4-Hexenoic acid, 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (E)-
Synonym: Acide mycophenolique
Synonym: Acido micofenolico
Synonym: Acidum mycophenolicum
Synonym: Apo-mycophenolic Acid
Synonym: MPA
Synonym: MYCOPHENOLIC ACID
Tree Number: T6.9.3.11
database_cross_reference: ATC:L04AA06
database_cross_reference: CSP:0201-9562
database_cross_reference: DRUGBANK:DB01024
database_cross_reference: LCH_NW:sh2010012388
database_cross_reference: MEDCIN:258953
database_cross_reference: MMSL:18132
database_cross_reference: MMSL:210716
database_cross_reference: MMSL:d05217
database_cross_reference: MSH:D009173
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:HU9DX48N0T
database_cross_reference: NCI:C673
database_cross_reference: NCI_DCP:30198
database_cross_reference: NCI_FDA:HU9DX48N0T
database_cross_reference: NDDF:005013
database_cross_reference: NDFRT:N0000007622
database_cross_reference: NDFRT:N0000148832
database_cross_reference: RXNORM:7145
database_cross_reference: SNOMEDCT_US:409330005
database_cross_reference: SNOMEDCT_US:409331009
database_cross_reference: USPMG:MTHU003316
database_cross_reference: VANDF:4021418

Penicillic Acid
type: Class
subclass of: PMO:00024389
MCID: MC00009809
PMOID: PMO:00016334
Subclass_of: Mycotoxins
Synonym: 2,5-Hexadienoic acid, 3-methoxy-5-methyl-4-oxo-
Synonym: Acid, Penicillic
Synonym: Penicillic Acid [Chemical/Ingredient]
Synonym: Penicillic acid
Synonym: Penicillic acid (substance)
Synonym: penicillic acid
Tree Number: T6.13.8.6.10
database_cross_reference: AOD:0000019904
database_cross_reference: MSH:D010398
database_cross_reference: NDFRT:N0000171415
database_cross_reference: SNMI:C-30815
database_cross_reference: SNOMEDCT_US:3145006

Caprylates
type: Class
subclass of: Acids, Acyclic
subclass of: PMO:00021087
MCID: MC00002196
PMOID: PMO:00016335
Subclass_of: Acids, Acyclic
Subclass_of: Fatty Acids
Synonym: Caprylates [Chemical/Ingredient]
Synonym: Octanoates
Synonym: caprylates
Synonym: octanoates
Tree Number: T6.2.12.1.5
Tree Number: T6.9.3.1
database_cross_reference: CHV:0000002372
database_cross_reference: MSH:D002210
database_cross_reference: NDFRT:N0000168588

Carbamates
type: Class
subclass of: Acids, Acyclic
MCID: MC00002204
PMOID: PMO:00016336
Subclass_of: Acids, Acyclic
Synonym: Carbamate
Synonym: Carbamate (substance)
Synonym: Carbamates [Chemical/Ingredient]
Synonym: Carbamates, NOS
Synonym: carbamate
Synonym: carbamates
Tree Number: T6.2.12.1.6
database_cross_reference: AOD:0000019890
database_cross_reference: CHV:0000002380
database_cross_reference: CSP:0543-1700
database_cross_reference: LCH:U000778
database_cross_reference: LCH_NW:sh85020069
database_cross_reference: LNC:LP19594-8
database_cross_reference: LNC:MTHU008703
database_cross_reference: MSH:D002219
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008124
database_cross_reference: SNMI:C-23260
database_cross_reference: SNOMEDCT_US:406748003
database_cross_reference: SNOMEDCT_US:79522001

Cobicistat
type: Class
subclass of: Thiazoles
MCID: MC00829729
PMOID: PMO:00016337
Subclass_of: Thiazoles
Synonym: 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate
Synonym: 2,7,10,12-Tetraazatridecanoic acid, 12-methyl-13-(2-(1-methylethyl)-4-thiazolyl)-9-(2-(4-morpholinyl)ethyl)-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3R,6R,9S)-
Synonym: COBICISTAT
Synonym: Cobicistat (product)
Synonym: Cobicistat (substance)
Synonym: Cobicistat [Chemical/Ingredient]
Synonym: antiviral pharmacokinetic enhancers cobicistat
Synonym: cobicistat
Synonym: cobicistat (medication)
Tree Number: T6.2.32.13.4
database_cross_reference: ATC:V03AX03
database_cross_reference: DRUGBANK:DB09065
database_cross_reference: MEDCIN:344274
database_cross_reference: MMSL:28748
database_cross_reference: MMSL:d07897
database_cross_reference: MSH:D000069547
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:LW2E03M5PG
database_cross_reference: NCI:C97360
database_cross_reference: NCI_FDA:LW2E03M5PG
database_cross_reference: NDDF:014623
database_cross_reference: NDFRT:N0000185511
database_cross_reference: NDFRT:N0000191982
database_cross_reference: RXNORM:1306284
database_cross_reference: SNOMEDCT_US:710109003
database_cross_reference: SNOMEDCT_US:714771003
database_cross_reference: VANDF:4031664

Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00973610
PMOID: PMO:00016338
Subclass_of: Drug Combinations
Synonym: Elvitegravir Cobicistat Emtricitabine Tenofovir Disoproxil Fumarate Drug Combination
Synonym: Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination [Chemical/Ingredient]
Synonym: Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate
Synonym: Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate Drug Combination
Synonym: Elvitegravir-Cobicistat-Emtricitabine-Tenofovir Disoproxil Fumarate Drug Combination
Synonym: Elvitegravir/ Cobicistat/ Emtricitabine/ Tenofovir disoproxil fumarate
Synonym: elvitegravir + cobicistat + emtricitabine + tenofovir disoproxil fumarate
Synonym: elvitegravir + cobicistat + emtricitabine + tenofovir disoproxil fumarate (medication)
Tree Number: T6.15.3.16
database_cross_reference: MEDCIN:343259
database_cross_reference: MSH:D000069545
database_cross_reference: NDFRT:N0000191986
database_cross_reference: USPMG:MTHU002717

Carbamyl Phosphate
type: Class
subclass of: Organophosphates
MCID: MC00002207
PMOID: PMO:00016342
Subclass_of: Organophosphates
Synonym: Carbamic acid, monoanhydride with phosphoric acid
Synonym: Carbamoyl Phosphate
Synonym: Carbamyl Phosphate [Chemical/Ingredient]
Synonym: Carbamyl phosphate
Synonym: Carbamyl phosphate (substance)
Synonym: Phosphate, Carbamoyl
Synonym: Phosphate, Carbamyl
Synonym: carbamoyl phosphate
Synonym: carbamyl phosphate
Tree Number: T6.2.29.5.1
database_cross_reference: CHV:0000002382
database_cross_reference: MSH:D002221
database_cross_reference: NDFRT:N0000166709
database_cross_reference: SNM:F-11600
database_cross_reference: SNMI:F-61600
database_cross_reference: SNOMEDCT_US:63789002

Diethylcarbamazine
type: Class
subclass of: Piperazines
MCID: MC00003888
PMOID: PMO:00016344
Subclass_of: Piperazines
Synonym: 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-
Synonym: Banocide Forte
Synonym: Carbamazine
Synonym: Carbilazine
Synonym: Caricide
Synonym: Cypip
Synonym: DIETHYLCARBAMAZINE
Synonym: Decet
Synonym: Dicarb
Synonym: Diethizine
Tree Number: T6.3.5.15.12
database_cross_reference: ATC:P02CB02
database_cross_reference: CHV:0000003925
database_cross_reference: CSP:0715-1475
database_cross_reference: CSP:2332-0723
database_cross_reference: DRUGBANK:DB00711
database_cross_reference: MEDCIN:40412
database_cross_reference: MSH:D004049
database_cross_reference: MTHSPL:V867Q8X3ZD
database_cross_reference: NCI:C65378
database_cross_reference: NCI_FDA:V867Q8X3ZD
database_cross_reference: NDDF:004969
database_cross_reference: NDFRT:N0000167124
database_cross_reference: RCD:ev1..
database_cross_reference: RXNORM:3384
database_cross_reference: SNM:E-7412
database_cross_reference: SNMI:C-56A91
database_cross_reference: SNOMEDCT_US:387340001
database_cross_reference: SNOMEDCT_US:60731009

Methomyl
type: Class
subclass of: Thiocarbamates
MCID: MC00008190
PMOID: PMO:00016348
Subclass_of: Thiocarbamates
Synonym: Ethanimidothioic acid, N-(((methylamino)carbonyl)oxy)-, methyl ester
Synonym: Methomyl (substance)
Synonym: Methomyl [Chemical/Ingredient]
Synonym: methomyl
Tree Number: T6.2.32.16.4
database_cross_reference: CHV:0000008043
database_cross_reference: LCH:U002938
database_cross_reference: LCH_NW:sh85084417
database_cross_reference: MSH:D008724
database_cross_reference: NDFRT:N0000166702
database_cross_reference: SNMI:C-23264
database_cross_reference: SNOMEDCT_US:42951000

Carbaryl
type: Class
subclass of: Naphthalenes
MCID: MC00011794
PMOID: PMO:00016349
Subclass_of: Naphthalenes
Synonym: 1-Naphthalenol, methylcarbamate
Synonym: 1-Naphthol N-methylcarbamate
Synonym: 1-Naphthyl-N-methylcarbamate
Synonym: CARBARIL
Synonym: Carbamine
Synonym: Carbaril
Synonym: Carbaryl (substance)
Synonym: Carbaryl [Chemical/Ingredient]
Synonym: Carbaryl product
Synonym: Carbaryl product (product)
Tree Number: T6.4.3.7.13
database_cross_reference: CHV:0000011258
database_cross_reference: LCH:U006138
database_cross_reference: LCH_NW:sh85020071
database_cross_reference: LNC:LP17975-1
database_cross_reference: LNC:MTHU009559
database_cross_reference: MSH:D012721
database_cross_reference: NCI:C76389
database_cross_reference: NCI_FDA:R890C8J3N1
database_cross_reference: NDDF:003720
database_cross_reference: NDFRT:N0000167377
database_cross_reference: RCD:XM0lV
database_cross_reference: RCD:mg2..
database_cross_reference: RXNORM:9724
database_cross_reference: SNMI:C-23261
database_cross_reference: SNOMEDCT_US:333035001
database_cross_reference: SNOMEDCT_US:9021002

Thiocarbamates
type: Class
subclass of: Sulfur Compounds
MCID: MC00012727
PMOID: PMO:00016350
Subclass_of: Sulfur Compounds
Synonym: Thiocarbamates [Chemical/Ingredient]
Synonym: thiocarbamate
Synonym: thiocarbamates
Tree Number: T6.2.32.16
database_cross_reference: AOD:0000019892
database_cross_reference: CSP:2903-8742
database_cross_reference: MSH:D013859
database_cross_reference: NDFRT:N0000008093

Ditiocarb
type: Class
subclass of: Thiocarbamates
MCID: MC00003890
PMOID: PMO:00016351
Subclass_of: Thiocarbamates
Synonym: Carbamodithioic acid, diethyl-
Synonym: DDTC
Synonym: DIECA
Synonym: DITIOCARB
Synonym: DTC
Synonym: Diethylcarbamodithioic Acid
Synonym: Diethyldione
Synonym: Diethyldithiocarbamic Acid
Synonym: Diethyldithiocarbaminic Acid
Synonym: Diethyldithione
Tree Number: T6.2.32.16.1
database_cross_reference: DRUGBANK:DB02520
database_cross_reference: MSH:D004050
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C432
database_cross_reference: NCI_DCP:01360
database_cross_reference: NCI_FDA:99Z2744345
database_cross_reference: NDFRT:N0000007514
database_cross_reference: PDQ:CDR0000040247

Dimethyldithiocarbamate
type: Class
subclass of: Thiocarbamates
MCID: MC00003965
PMOID: PMO:00016353
Subclass_of: Thiocarbamates
Synonym: Dimethyldithiocarbamate [Chemical/Ingredient]
Synonym: dimethyldithiocarbamate
Tree Number: T6.2.32.16.2
database_cross_reference: AOD:0000019894
database_cross_reference: MSH:D004125
database_cross_reference: NDFRT:N0000166712

Ethylenebis(dithiocarbamates)
type: Class
subclass of: Thiocarbamates
MCID: MC00004806
PMOID: PMO:00016356
Subclass_of: Thiocarbamates
Synonym: Ethylenebis(dithiocarbamates) [Chemical/Ingredient]
Tree Number: T6.2.32.16.3
database_cross_reference: MSH:D005028
database_cross_reference: NDFRT:N0000166711

Maneb
type: Class
subclass of: Organometallic Compounds
MCID: MC00007883
PMOID: PMO:00016357
Subclass_of: Organometallic Compounds
Synonym: Maneb (product)
Synonym: Maneb (substance)
Synonym: Maneb [Chemical/Ingredient]
Synonym: Manganese, ((1,2-ethanediylbis(carbamodithioato))(2-))-
Tree Number: T6.2.28.6
database_cross_reference: LCH_NW:sh2008020248
database_cross_reference: MSH:D008344
database_cross_reference: NDFRT:N0000166772
database_cross_reference: RCD:X79J4
database_cross_reference: SNM:E-6514
database_cross_reference: SNMI:C-23703
database_cross_reference: SNOMEDCT_US:411382004
database_cross_reference: SNOMEDCT_US:54651009

Zineb
type: Class
subclass of: Organometallic Compounds
MCID: MC00013823
PMOID: PMO:00016358
Subclass_of: Organometallic Compounds
Synonym: Zinc Ethylenebis(dithiocarbamate)
Synonym: Zinc ethylenebis
Synonym: Zinc ethylenebis(dithiocarbamate)
Synonym: Zinc ethylenebis(dithiocarbamate) (product)
Synonym: Zinc ethylenebis(dithiocarbamate) (substance)
Synonym: Zinc, ((1,2-ethanediylbis(carbamodithioato))(2-))-
Synonym: Zineb (product)
Synonym: Zineb (substance)
Synonym: Zineb [Chemical/Ingredient]
Tree Number: T6.2.28.12
database_cross_reference: MSH:D015038
database_cross_reference: NDFRT:N0000166782
database_cross_reference: RCD:X79IF
database_cross_reference: RCD:X79J6
database_cross_reference: SNM:E-6515
database_cross_reference: SNMI:C-23704
database_cross_reference: SNOMEDCT_US:256005005
database_cross_reference: SNOMEDCT_US:411384003
database_cross_reference: SNOMEDCT_US:411385002
database_cross_reference: SNOMEDCT_US:57899001

Tolnaftate
type: Class
subclass of: Thiocarbamates
subclass of: Naphthalenes
MCID: MC00012899
PMOID: PMO:00016359
Subclass_of: Naphthalenes
Subclass_of: Thiocarbamates
Synonym: 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate
Synonym: Absorbine Antifungal Powder 1%
Synonym: Absorbine Jr Antifungal Liq
Synonym: Absorbine Jr Antifungal Liquid
Synonym: Aftate Athlete Foot Cream
Synonym: Antifungal Cream
Synonym: Antifungal Foot Care
Synonym: Athlete's Foot Gel 1%
Synonym: Athlete's Foot Spray Power
Synonym: Athletes Foot Medicated Antifungal
Tree Number: T6.2.32.16.5
Tree Number: T6.4.3.7.15
database_cross_reference: ATC:D01AE18
database_cross_reference: CHV:0000012342
database_cross_reference: DRUGBANK:DB00525
database_cross_reference: MEDCIN:40716
database_cross_reference: MMSL:4874
database_cross_reference: MMSL:5599
database_cross_reference: MSH:D014047
database_cross_reference: MTHSPL:06KB629TKV
database_cross_reference: NCI:C47763
database_cross_reference: NCI_FDA:06KB629TKV
database_cross_reference: NDDF:002904
database_cross_reference: NDFRT:N0000005933
database_cross_reference: NDFRT:N0000147552
database_cross_reference: RCD:med..
database_cross_reference: RXNORM:10637
database_cross_reference: SNM:E-730X
database_cross_reference: SNMI:C-90B20
database_cross_reference: SNOMEDCT_US:38166006
database_cross_reference: SNOMEDCT_US:387204001
database_cross_reference: VANDF:4019415

Triallate
type: Class
subclass of: Thiocarbamates
MCID: MC00013037
PMOID: PMO:00016360
Subclass_of: Thiocarbamates
Synonym: Carbamothioic acid, bis(1-methylethyl)-, S-(2,3,3-trichloro-2-propenyl) ester
Synonym: Tri allate
Synonym: Tri-allate
Synonym: Triallate [Chemical/Ingredient]
Tree Number: T6.2.32.16.6
database_cross_reference: MSH:D014214
database_cross_reference: NDFRT:N0000166715

Nitrosomethylurethane
type: Class
subclass of: Nitroso Compounds
MCID: MC00008961
PMOID: PMO:00016363
Subclass_of: Nitroso Compounds
Synonym: Carbamic acid, methylnitroso-, ethyl ester
Synonym: Methylnitrosourethane
Synonym: Nitrosomethylurethane [Chemical/Ingredient]
Tree Number: T6.2.26.3
database_cross_reference: MSH:D009605
database_cross_reference: NDFRT:N0000166751

Polyurethanes
type: Class
subclass of: Plastics
subclass of: PMO:00024438
MCID: MC00010477
PMOID: PMO:00016364
Subclass_of: Elastomers
Subclass_of: Plastics
Synonym: Ostamer
Synonym: Ostamers
Synonym: POLYURETHANE
Synonym: Pellethane
Synonym: Pellethanes
Synonym: Polyisocyanate
Synonym: Polyisocyanate (substance)
Synonym: Polyisocyanates
Synonym: Polyurethane
Synonym: Polyurethanes [Chemical/Ingredient]
Tree Number: T6.14.9.14.2
Tree Number: T6.14.9.6.5
Tree Number: T6.5.2.8.5
database_cross_reference: CHV:0000009949
database_cross_reference: CSP:2349-0441
database_cross_reference: LCH:U003767
database_cross_reference: LCH_NW:sh85104740
database_cross_reference: MSH:D011140
database_cross_reference: NDFRT:N0000171539
database_cross_reference: NDFRT:N0000177945
database_cross_reference: RCD:X79C1
database_cross_reference: SNOMEDCT_US:255781002
database_cross_reference: VANDF:4028233

Physostigmine
type: Class
subclass of: Indole Alkaloids
MCID: MC00010186
PMOID: PMO:00016373
Subclass_of: Indole Alkaloids
Synonym: Antilirium Inj 1mg/ml
Synonym: PHYSOSTIGMINE
Synonym: Physostigmine (product)
Synonym: Physostigmine (substance)
Synonym: Physostigmine [Chemical/Ingredient]
Synonym: Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-
Synonym: physostigmine
Synonym: physostigmines
Synonym: physostigmines (medication)
Tree Number: T6.3.3.25.3
database_cross_reference: AOD:0000020517
database_cross_reference: ATC:S01EB05
database_cross_reference: ATC:V03AB19
database_cross_reference: CHV:0000009715
database_cross_reference: CSP:0397-6388
database_cross_reference: DRUGBANK:DB00981
database_cross_reference: LCH_NW:sh2010009087
database_cross_reference: MEDCIN:250548
database_cross_reference: MMSL:d00342
database_cross_reference: MSH:D010830
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9U1VM840SP
database_cross_reference: NCI:C81337
database_cross_reference: NCI_FDA:9U1VM840SP
database_cross_reference: NDDF:001700
database_cross_reference: NDFRT:N0000007908
database_cross_reference: NDFRT:N0000147979
database_cross_reference: PSY:38750
database_cross_reference: RCD:x01DC
database_cross_reference: RXNORM:8299
database_cross_reference: SNM:E-7532
database_cross_reference: SNMI:C-67140
database_cross_reference: SNOMEDCT_US:373347005
database_cross_reference: SNOMEDCT_US:85429009
database_cross_reference: VANDF:4019894

Dicarboxylic Acids
type: Class
subclass of: Acids, Acyclic
MCID: MC00003854
PMOID: PMO:00016375
Subclass_of: Acids, Acyclic
Synonym: Acids, Dicarboxylic
Synonym: Dicarboxylic Acid
Synonym: Dicarboxylic Acids [Chemical/Ingredient]
Synonym: dicarboxylic acid
Synonym: dicarboxylic acids
Tree Number: T6.2.12.1.7
database_cross_reference: AOD:0000019998
database_cross_reference: CHV:0000003884
database_cross_reference: MSH:D003998
database_cross_reference: NCI:C120005
database_cross_reference: NDFRT:N0000007971

Dimethyl Adipimidate
type: Class
subclass of: Imidoesters
MCID: MC00003959
PMOID: PMO:00016377
Subclass_of: Imidoesters
Synonym: Adipimate, Dimethyl
Synonym: Adipimidate, Dimethyl
Synonym: Adipinamidate, Dimethyl
Synonym: Dimethyl Adipimate
Synonym: Dimethyl Adipimidate [Chemical/Ingredient]
Synonym: Dimethyl Adipinamidate
Synonym: Hexanediimidic acid, dimethyl ester
Tree Number: T6.2.18.1.1
database_cross_reference: MSH:D004119
database_cross_reference: NDFRT:N0000166723

2-Aminoadipic Acid
type: Class
subclass of: PMO:00021298
MCID: MC00000036
PMOID: PMO:00016378
Subclass_of: Amino Acids, Dicarboxylic
Synonym: 2 Aminoadipic Acid
Synonym: 2 Aminohexanedioic Acid
Synonym: 2-Aminoadipic Acid [Chemical/Ingredient]
Synonym: 2-Aminoadipic acid
Synonym: 2-Aminohexanedioic Acid
Synonym: AMINOADIPIC ACID 02
Synonym: Acid, 2 Aminoadipic
Synonym: Acid, 2-Aminoadipic
Synonym: Acid, 2-Aminohexanedioic
Synonym: Acid, alpha-Aminoadipic
Tree Number: T6.10.1.6.7
database_cross_reference: MSH:D015074
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118881
database_cross_reference: NDFRT:N0000170288
database_cross_reference: SNMI:C-21673
database_cross_reference: SNOMEDCT_US:95984008

Ketoglutaric Acids
type: Class
subclass of: Keto Acids
MCID: MC00007229
PMOID: PMO:00016384
Subclass_of: Keto Acids
Synonym: Acids, Ketoglutaric
Synonym: Ketoglutaric Acids [Chemical/Ingredient]
Synonym: Oxoglutarates
Tree Number: T6.2.12.7.3
database_cross_reference: MSH:D007656
database_cross_reference: NDFRT:N0000166732

Malates
type: Class
subclass of: Hydroxy Acids
MCID: MC00007849
PMOID: PMO:00016386
Subclass_of: Hydroxy Acids
Synonym: Malates [Chemical/Ingredient]
Tree Number: T6.2.12.6.6
database_cross_reference: MSH:D008293
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008226

Thiomalates
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00012739
PMOID: PMO:00016387
Subclass_of: Sulfhydryl Compounds
Synonym: Thiomalates [Chemical/Ingredient]
Synonym: thiomalate
Synonym: thiomalates
Tree Number: T6.2.32.6.11
database_cross_reference: CHV:0000012189
database_cross_reference: MSH:D013870
database_cross_reference: NDFRT:N0000008099

Gold Sodium Thiomalate
type: Class
subclass of: Organogold Compounds
MCID: MC00005791
PMOID: PMO:00016388
Subclass_of: Organogold Compounds
Synonym: Aurothiomalate Disodium
Synonym: Aurothiomalate, Sodium
Synonym: Butanedioic acid, mercapto-, monogold(1+) sodium salt
Synonym: GOLD SODIUM THIOMALATE
Synonym: Gold Sodium Thiomalate [Chemical/Ingredient]
Synonym: Gold Thiomalate, Sodium
Synonym: Gold sodium thiomalate
Synonym: Gold sodium thiomalate (product)
Synonym: Gold sodium thiomalate (substance)
Synonym: Mercaptobutanedioic Acid Monogold(1+) Sodium Salt
Tree Number: T6.2.28.15.2
database_cross_reference: ATC:M01CB01
database_cross_reference: CHV:0000005647
database_cross_reference: DRUGBANK:DB09276
database_cross_reference: MEDCIN:199073
database_cross_reference: MMSL:4795
database_cross_reference: MMSL:615
database_cross_reference: MMSL:d00250
database_cross_reference: MSH:D006052
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C74037
database_cross_reference: NCI_FDA:E4768ZY6GM
database_cross_reference: NDDF:002396
database_cross_reference: NDFRT:N0000006015
database_cross_reference: NDFRT:N0000146340
database_cross_reference: RCD:j51..
database_cross_reference: RXNORM:4981
database_cross_reference: SNM:E-8977
database_cross_reference: SNMI:C-B8214
database_cross_reference: SNOMEDCT_US:387380005
database_cross_reference: SNOMEDCT_US:68702006
database_cross_reference: VANDF:4017995

Maleimides
type: Class
subclass of: Imides
MCID: MC00007855
PMOID: PMO:00016390
Subclass_of: Imides
Synonym: Maleimides [Chemical/Ingredient]
Synonym: maleimide
Tree Number: T6.2.18.2
database_cross_reference: CSP:2521-2719
database_cross_reference: MSH:D008301
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167051

Ethylmaleimide
type: Class
subclass of: Maleimides
MCID: MC00004812
PMOID: PMO:00016391
Subclass_of: Maleimides
Synonym: 1H-Pyrrole-2,5-dione, 1-ethyl-
Synonym: Ethylmaleimide [Chemical/Ingredient]
Synonym: N Ethylmaleimide
Synonym: N-Ethylmaleimide
Synonym: NEM (N ethylmaleimide)
Tree Number: T6.2.18.2.1
database_cross_reference: CSP:2521-2719
database_cross_reference: DRUGBANK:DB02967
database_cross_reference: MSH:D005033
database_cross_reference: NDFRT:N0000167052

Oxaloacetates
type: Class
subclass of: Keto Acids
MCID: MC00009550
PMOID: PMO:00016396
Subclass_of: Keto Acids
Synonym: Ketosuccinates
Synonym: Oxaloacetates [Chemical/Ingredient]
Synonym: Oxosuccinates
Synonym: oxaloacetate
Tree Number: T6.2.12.7.5
database_cross_reference: CHV:0000009138
database_cross_reference: CSP:0880-9694
database_cross_reference: MSH:D010071
database_cross_reference: MTH:U002132
database_cross_reference: NDFRT:N0000166727

Diaminopimelic Acid
type: Class
subclass of: PMO:00021283
MCID: MC00003814
PMOID: PMO:00016401
Subclass_of: Amino Acids, Diamino
Synonym: 2,6 Diaminopimelic Acid
Synonym: 2,6 Diaminopimelic acid
Synonym: 2,6-Diaminopimelic Acid
Synonym: Acid, 2,6-Diaminopimelic
Synonym: Acid, Diaminopimelic
Synonym: Diaminopimelate
Synonym: Diaminopimelic Acid [Chemical/Ingredient]
Synonym: Diaminopimelic acid
Synonym: Diaminopimelic acid (substance)
Synonym: Heptanedioic acid, 2,6-diamino-
Tree Number: T6.10.1.5.6
database_cross_reference: DRUGBANK:DB03590
database_cross_reference: MSH:D003960
database_cross_reference: NDFRT:N0000170240
database_cross_reference: SNOMEDCT_US:410983005

Succimer
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00003953
PMOID: PMO:00016404
Subclass_of: Sulfhydryl Compounds
Synonym: Acid, meso-Dimercaptosuccinic
Synonym: Butanedioic Acid, 2,3-Dimercapto-, (2R,3S)-rel-
Synonym: Butanedioic Acid, 2,3-Dimercapto-, (R*,S*)-Isomer
Synonym: Butanedioic acid, 2,3-dimercapto-, (R*,S*)-
Synonym: DMSA
Synonym: Meso 2, 3-Dimercaptosuccinic Acid
Synonym: SUCCIMER
Synonym: Succimer (product)
Synonym: Succimer (substance)
Synonym: Succimer [Chemical/Ingredient]
Tree Number: T6.2.32.6.3
database_cross_reference: CHV:0000003962
database_cross_reference: CHV:0000020701
database_cross_reference: CSP:0881-0255
database_cross_reference: DRUGBANK:DB00566
database_cross_reference: LNC:LP35288-7
database_cross_reference: MEDCIN:48825
database_cross_reference: MMSL:194288
database_cross_reference: MMSL:5516
database_cross_reference: MMSL:NOCODE
database_cross_reference: MMSL:d01417
database_cross_reference: MSH:D004113
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:DX1U2629QE
database_cross_reference: NCI:C61953
database_cross_reference: NCI_FDA:DX1U2629QE
database_cross_reference: NDDF:003583
database_cross_reference: NDFRT:N0000006686
database_cross_reference: NDFRT:N0000147417
database_cross_reference: RXNORM:3446
database_cross_reference: SNOMEDCT_US:109104002
database_cross_reference: SNOMEDCT_US:397224000
database_cross_reference: USPMG:MTHU003568
database_cross_reference: VANDF:4019174

Technetium Tc 99m Dimercaptosuccinic Acid
type: Class
subclass of: Organotechnetium Compounds
MCID: MC00038797
PMOID: PMO:00016405
Subclass_of: Organotechnetium Compounds
Synonym: 99Tc Succimer
Synonym: 99Tc-Succimer
Synonym: 99m Tc Dimercaptosuccinic Acid
Synonym: 99m-Tc-Dimercaptosuccinic Acid
Synonym: 99mTc DMSA
Synonym: 99mTc Dimercaptosuccinic Acid
Synonym: 99mTc-DMSA
Synonym: 99mTc-Dimercaptosuccinic Acid
Synonym: Acid, 99m-Tc-Dimercaptosuccinic
Synonym: Acid, 99mTc-Dimercaptosuccinic
Tree Number: T6.2.28.13.8
database_cross_reference: ATC:V09CA02
database_cross_reference: MSH:D019783
database_cross_reference: NCI:C87408
database_cross_reference: NCI_FDA:494JNQ8L28
database_cross_reference: NDFRT:N0000166770
database_cross_reference: SNM:E-5278
database_cross_reference: SNMI:C-B1221
database_cross_reference: SNOMEDCT_US:24511001
database_cross_reference: SNOMEDCT_US:447201007
database_cross_reference: SNOMEDCT_US:703377004

Tartrates
type: Class
subclass of: Sugar Acids
MCID: MC00012557
PMOID: PMO:00016408
Subclass_of: Sugar Acids
Synonym: Tartrates [Chemical/Ingredient]
Synonym: tartrate
Synonym: tartrates
Tree Number: T6.8.8.7
database_cross_reference: CHV:0000012039
database_cross_reference: CSP:0880-7076
database_cross_reference: MSH:D013644
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007763

Tartronates
type: Class
subclass of: Sugar Acids
MCID: MC00012559
PMOID: PMO:00016409
Subclass_of: Sugar Acids
Synonym: Acids, Hydroxymalonic
Synonym: Hydroxymalonic Acids
Synonym: Tartronate
Synonym: Tartronates [Chemical/Ingredient]
Tree Number: T6.8.8.8
database_cross_reference: DRUGBANK:DB03680
database_cross_reference: MSH:D013646
database_cross_reference: NDFRT:N0000168489

Formates
type: Class
subclass of: Acids, Acyclic
MCID: MC00005268
PMOID: PMO:00016410
Subclass_of: Acids, Acyclic
Synonym: Formate
Synonym: Formates [Chemical/Ingredient]
Synonym: formate
Tree Number: T6.2.12.1.8
database_cross_reference: CHV:0000005219
database_cross_reference: CSP:0562-8677
database_cross_reference: DRUGBANK:DB01942
database_cross_reference: MSH:D005561
database_cross_reference: MTH:U001934
database_cross_reference: NDFRT:N0000166689

Imino Acids
type: Class
subclass of: Acids, Acyclic
subclass of: Imines
subclass of: PMO:00021266
MCID: MC00006721
PMOID: PMO:00016413
Subclass_of: Acids, Acyclic
Subclass_of: Amino Acids, Cyclic
Subclass_of: Imines
Synonym: AA SECOND
Synonym: ACIDS SECOND AMINO
Synonym: Acids, Imino
Synonym: Acids, Secondary Amino
Synonym: Amino Acids, Secondary
Synonym: Imino Acids [Chemical/Ingredient]
Synonym: Imino acid
Synonym: Imino acid (substance)
Synonym: Imino acid, NOS
Synonym: Imino acids
Tree Number: T6.10.1.4.4
Tree Number: T6.2.12.1.9
Tree Number: T6.2.19.2
database_cross_reference: AOD:0000020254
database_cross_reference: CSP:0124-2825
database_cross_reference: LCH:U002372
database_cross_reference: LCH_NW:sh85064496
database_cross_reference: MSH:D007098
database_cross_reference: NDFRT:N0000007771
database_cross_reference: SNM:F-14780
database_cross_reference: SNMI:F-64580
database_cross_reference: SNOMEDCT_US:39862002

Azetidinecarboxylic Acid
type: Class
subclass of: Imino Acids
MCID: MC00001436
PMOID: PMO:00016414
Subclass_of: Imino Acids
Synonym: 2-Azetidinecarboxylic acid
Synonym: Acid, Azetidine-2-carboxylic
Synonym: Acid, Azetidinecarboxylic
Synonym: Azetidine 2 carboxylic Acid
Synonym: Azetidine-2-carboxylic Acid
Synonym: Azetidinecarboxylic Acid [Chemical/Ingredient]
Tree Number: T6.2.19.2.1
database_cross_reference: MSH:D001383
database_cross_reference: NDFRT:N0000170256

Technetium Tc 99m Lidofenin
type: Class
subclass of: Imino Acids
subclass of: Organotechnetium Compounds
MCID: MC00038819
PMOID: PMO:00016415
Subclass_of: Imino Acids
Subclass_of: Organotechnetium Compounds
Synonym: 99m Tc Lidofenin
Synonym: 99m-Tc-Lidofenin
Synonym: 99mTc HIDA
Synonym: 99mTc Lidofenin
Synonym: 99mTc-HIDA
Synonym: 99mTc-Lidofenin
Synonym: 99mtc-hida
Synonym: Lidofenin, Tc-99m
Synonym: TC LIDOFENIN 099M
Synonym: TECHNETIUM TC LIDOFENIN 099M
Tree Number: T6.2.19.2.2
Tree Number: T6.2.28.13.7
database_cross_reference: ATC:V09DA03
database_cross_reference: CHV:0000014903
database_cross_reference: MSH:D019780
database_cross_reference: NDFRT:N0000170259
database_cross_reference: SNMI:C-B1209
database_cross_reference: SNOMEDCT_US:7281000

Technetium Tc 99m Diethyl-iminodiacetic Acid
type: Class
subclass of: Imino Acids
subclass of: Organotechnetium Compounds
MCID: MC00038794
PMOID: PMO:00016416
Subclass_of: Imino Acids
Subclass_of: Organotechnetium Compounds
Synonym: 99m Tc Diethyl IDA
Synonym: 99m-Tc-Diethyl IDA
Synonym: 99mTc Diethyl IDA
Synonym: 99mTc Diethyliminodiacetic Acid
Synonym: 99mTc EHIDA
Synonym: 99mTc-Diethyl IDA
Synonym: 99mTc-Diethyliminodiacetic Acid
Synonym: 99mTc-EHIDA
Synonym: Acid, 99mTc-Diethyliminodiacetic
Synonym: IDA, 99m-Tc-Diethyl
Tree Number: T6.2.19.2.3
Tree Number: T6.2.28.13.9
database_cross_reference: MSH:D019784
database_cross_reference: NDFRT:N0000170258

Technetium Tc 99m Disofenin
type: Class
subclass of: Imino Acids
subclass of: Organotechnetium Compounds
MCID: MC00038800
PMOID: PMO:00016417
Subclass_of: Imino Acids
Subclass_of: Organotechnetium Compounds
Synonym: 99m Tc Disofenin
Synonym: 99m-Tc-Disofenin
Synonym: 99mTc DISIDA
Synonym: 99mTc Disofenin
Synonym: 99mTc-DISIDA
Synonym: 99mTc-Disofenin
Synonym: Acid, Technetium-99m-Diisopropyliminodiacetic
Synonym: Disofenin, Tc-99m
Synonym: Kit for the Preparation of Technetium Tc99m Disofenin
Synonym: TC DISIDA
Tree Number: T6.2.19.2.4
Tree Number: T6.2.28.13.10
database_cross_reference: ATC:V09DA01
database_cross_reference: DRUGBANK:DB09164
database_cross_reference: MSH:D019785
database_cross_reference: MTHSPL:QTJ2VIW97T
database_cross_reference: NCI:C87401
database_cross_reference: NCI_FDA:QTJ2VIW97T
database_cross_reference: NDFRT:N0000006863
database_cross_reference: NDFRT:N0000146523
database_cross_reference: RXNORM:37665
database_cross_reference: SNMI:C-B1207
database_cross_reference: SNOMEDCT_US:3040004
database_cross_reference: VANDF:4018189

Propionates
type: Class
subclass of: Acids, Acyclic
subclass of: PMO:00021158
MCID: MC00010719
PMOID: PMO:00016418
Subclass_of: Acids, Acyclic
Subclass_of: Fatty Acids, Volatile
Synonym: Propanoates
Synonym: Propionates [Chemical/Ingredient]
Synonym: propionate
Tree Number: T6.2.12.1.10
Tree Number: T6.9.3.6.4
database_cross_reference: AOD:0000019877
database_cross_reference: CSP:1129-3653
database_cross_reference: LCH:U003859
database_cross_reference: LCH_NW:sh85107534
database_cross_reference: MSH:D011422
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007677

3-Mercaptopropionic Acid
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00000068
PMOID: PMO:00016422
Subclass_of: Sulfhydryl Compounds
Synonym: 3 Mercaptopropanoic Acid
Synonym: 3 Mercaptopropionic Acid
Synonym: 3-Mercaptopropanoic Acid
Synonym: 3-Mercaptopropionic Acid [Chemical/Ingredient]
Synonym: Acid, 3-Mercaptopropanoic
Synonym: Acid, 3-Mercaptopropionic
Synonym: MERCAPTOPROPANOIC ACID 03
Synonym: MERCAPTOPROPIONIC ACID 03
Synonym: Propanoic acid, 3-mercapto-
Tree Number: T6.2.32.6.13
database_cross_reference: MSH:D015097
database_cross_reference: NDFRT:N0000166740

Sugar Acids
type: Class
subclass of: Acids, Acyclic
subclass of: Hydroxy Acids
subclass of: PMO:00020868
MCID: MC00012349
PMOID: PMO:00016424
Subclass_of: Acids, Acyclic
Subclass_of: Carbohydrates
Subclass_of: Hydroxy Acids
Synonym: Acids, Sugar
Synonym: Sugar Acids [Chemical/Ingredient]
Synonym: Sugar acid
Synonym: Sugar acid (substance)
Synonym: sugar acid
Synonym: sugar acids
Tree Number: T6.2.12.1.11
Tree Number: T6.2.12.6.13
Tree Number: T6.8.8
database_cross_reference: AOD:0000019851
database_cross_reference: CSP:2828-2376
database_cross_reference: MSH:D013400
database_cross_reference: NDFRT:N0000008028
database_cross_reference: SNOMEDCT_US:438901003

Ascorbic Acid
type: Class
subclass of: Sugar Acids
MCID: MC00001290
PMOID: PMO:00016425
Subclass_of: Sugar Acids
Synonym: 2-(1,2-dihydroxyethyl)-4,5-dihydroxy-furan-3-one
Synonym: A & C Powder
Synonym: A46 VITAMIN C PREPARATIONS
Synonym: ASCORBIC ACID
Synonym: Acerotab
Synonym: Acetabolan III Vitamin and Mineral Supplement
Synonym: Acetabolan-II Vitamin and Mineral Supplement
Synonym: Acid, Ascorbic
Synonym: Acid, L-Ascorbic
Synonym: Acti-MN + B1 + C Caplet
Tree Number: T6.8.8.1
database_cross_reference: AOD:0000018216
database_cross_reference: AOD:0000028202
database_cross_reference: ATC:A11GA01
database_cross_reference: ATC:G01AD03
database_cross_reference: ATC:S01XA15
database_cross_reference: CHV:0000001505
database_cross_reference: CSP:3147-6588
database_cross_reference: DRUGBANK:DB00126
database_cross_reference: LCH_NW:sh85143977
database_cross_reference: MEDCIN:199136
database_cross_reference: MEDLINEPLUS:5380
database_cross_reference: MMSL:1132
database_cross_reference: MMSL:4221
database_cross_reference: MMSL:5687
database_cross_reference: MMSL:6032
database_cross_reference: MMSL:d00426
database_cross_reference: MSH:D001205
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:PQ6CK8PD0R
database_cross_reference: NCI:C285
database_cross_reference: NCI_CRCH:C285
database_cross_reference: NCI_DCP:00243
database_cross_reference: NCI_DTP:NSC0033832
database_cross_reference: NCI_FDA:PQ6CK8PD0R
database_cross_reference: NCI_NCI-GLOSS:CDR0000439435
database_cross_reference: NCI_NCI-GLOSS:CDR0000439436
database_cross_reference: NDDF:001010
database_cross_reference: NDFRT:N0000006439
database_cross_reference: NDFRT:N0000145859
database_cross_reference: NDFRT:N0000146025
database_cross_reference: PDQ:CDR0000039737
database_cross_reference: PSY:03980
database_cross_reference: PSY:56030
database_cross_reference: RCD:X80RY
database_cross_reference: RCD:ge1..
database_cross_reference: RCD:io...
database_cross_reference: RCD:io1..
database_cross_reference: RXNORM:1151
database_cross_reference: SNM:E-8751
database_cross_reference: SNM:F-16270
database_cross_reference: SNMI:C-A4600
database_cross_reference: SNMI:F-BB370
database_cross_reference: SNOMEDCT_US:326586001
database_cross_reference: SNOMEDCT_US:329313003
database_cross_reference: SNOMEDCT_US:43706004
database_cross_reference: SNOMEDCT_US:46123006
database_cross_reference: VANDF:4017471
database_cross_reference: VANDF:4017646

Dehydroascorbic Acid
type: Class
subclass of: Ascorbic Acid
subclass of: Lactones
MCID: MC00003589
PMOID: PMO:00016426
Subclass_of: Ascorbic Acid
Subclass_of: Lactones
Synonym: 5-(1,2-dihydroxyethyl)oxolane-2,3,4-trione
Synonym: Acid, Dehydroascorbic
Synonym: DEHYDROASCORBIC ACID
Synonym: DHAA
Synonym: Dehydroascorbic Acid [Chemical/Ingredient]
Synonym: Dehydroascorbic acid
Synonym: L-dehydroascorbate
Synonym: L-dehydroascorbic acid
Synonym: L-threo-2,3-Hexodiulosonic acid, gamma-lactone
Synonym: L-threo-2,3-hexodiulosonic acid, γ-lactone
Tree Number: T6.2.21.1
Tree Number: T6.8.8.1.1
database_cross_reference: AOD:0000018218
database_cross_reference: DRUGBANK:DB08830
database_cross_reference: MSH:D003683
database_cross_reference: NCI:C68508
database_cross_reference: NCI_CRCH:C68508
database_cross_reference: NCI_FDA:Y2Z3ZTP9UM
database_cross_reference: NDFRT:N0000168481
database_cross_reference: SNOMEDCT_US:707244004

Glucaric Acid
type: Class
subclass of: Sugar Acids
MCID: MC00005659
PMOID: PMO:00016427
Subclass_of: Sugar Acids
Synonym: Acid, Saccharic
Synonym: D Glucaric Acid
Synonym: D Saccharic Acid
Synonym: D-Glucaric Acid
Synonym: D-Saccharic Acid
Synonym: Glucaric Acid [Chemical/Ingredient]
Synonym: Glucaric acid
Synonym: Glucosaccharic Acid
Synonym: Saccharic Acid
Synonym: Tetrahydroxyadipic Acid
Tree Number: T6.8.8.2
database_cross_reference: DRUGBANK:DB03603
database_cross_reference: MSH:D005937
database_cross_reference: NDFRT:N0000168487

Gluconates
type: Class
subclass of: Sugar Acids
MCID: MC00005666
PMOID: PMO:00016428
Subclass_of: Sugar Acids
Synonym: Gluconates [Chemical/Ingredient]
Synonym: gluconate
Tree Number: T6.8.8.3
database_cross_reference: CSP:2828-3356
database_cross_reference: MSH:D005942
database_cross_reference: MTH:U001952
database_cross_reference: NDFRT:N0000006390

Antimony Sodium Gluconate
type: Class
subclass of: Gluconates
subclass of: Organometallic Compounds
MCID: MC00001087
PMOID: PMO:00016429
Subclass_of: Gluconates
Subclass_of: Organometallic Compounds
Synonym: Antimony Gluconate Sodium
Synonym: Antimony Sodium Gluconate [Chemical/Ingredient]
Synonym: SSG
Synonym: Sodium Stibogluconate
Synonym: Sodium, Stibogluconate
Synonym: Stibogluconate Sodium
Synonym: Stibogluconate, Sodium
Synonym: antimony sodium gluconate
Synonym: sodium antimony gluconate
Tree Number: T6.2.28.4
Tree Number: T6.8.8.3.1
database_cross_reference: CHV:0000001311
database_cross_reference: MSH:D000967
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C61083
database_cross_reference: NCI_NCI-GLOSS:CDR0000523297
database_cross_reference: NDFRT:N0000168480

Calcium Gluconate
type: Class
subclass of: Gluconates
MCID: MC00002119
PMOID: PMO:00016430
Subclass_of: Gluconates
Synonym: CALCIUM GLUCONATE
Synonym: CALGLUC
Synonym: Calcarea gluconica
Synonym: Calcii gluconas
Synonym: Calcium D-gluconate
Synonym: Calcium Gluconate 10% Inj 100mg/ml
Synonym: Calcium Gluconate Inj USP 10%
Synonym: Calcium Gluconate Injection USP
Synonym: Calcium Gluconate Tab 600mg
Synonym: Calcium Gluconate Tab 648mg
Tree Number: T6.8.8.3.2
database_cross_reference: ATC:A12AA03
database_cross_reference: ATC:D11AX03
database_cross_reference: CHV:0000002300
database_cross_reference: DRUGBANK:DB11126
database_cross_reference: MEDCIN:41231
database_cross_reference: MMSL:20
database_cross_reference: MMSL:4337
database_cross_reference: MMSL:d03800
database_cross_reference: MSH:D002125
database_cross_reference: MTHSPL:SQE6VB453K
database_cross_reference: NCI:C336
database_cross_reference: NCI_DCP:00985
database_cross_reference: NCI_FDA:SQE6VB453K
database_cross_reference: NCI_NCI-GLOSS:CDR0000483995
database_cross_reference: NDDF:000777
database_cross_reference: NDFRT:N0000006549
database_cross_reference: NDFRT:N0000146426
database_cross_reference: PDQ:CDR0000039172
database_cross_reference: RCD:x01Pc
database_cross_reference: RXNORM:1908
database_cross_reference: SNM:E-8723
database_cross_reference: SNMI:C-71014
database_cross_reference: SNOMEDCT_US:387292008
database_cross_reference: SNOMEDCT_US:53691001
database_cross_reference: VANDF:4018087

Glyceric Acids
type: Class
subclass of: Sugar Acids
MCID: MC00005722
PMOID: PMO:00016431
Subclass_of: Sugar Acids
Synonym: Acids, Glyceric
Synonym: Glyceric Acids [Chemical/Ingredient]
Tree Number: T6.8.8.4
database_cross_reference: MSH:D005988
database_cross_reference: NDFRT:N0000168490

Diphosphoglyceric Acids
type: Class
subclass of: Glyceric Acids
subclass of: Organophosphates
MCID: MC00004012
PMOID: PMO:00016432
Subclass_of: Glyceric Acids
Subclass_of: Organophosphates
Synonym: Acids, Diphosphoglyceric
Synonym: Bisphosphoglycerates
Synonym: Diphosphoglyceric Acids [Chemical/Ingredient]
Synonym: Diphosphoglyceric acid
Synonym: Diphosphoglyceric acid (substance)
Tree Number: T6.2.29.5.4
Tree Number: T6.8.8.4.1
database_cross_reference: MSH:D004163
database_cross_reference: NDFRT:N0000168491
database_cross_reference: SNOMEDCT_US:125713008

Muramic Acids
type: Class
subclass of: Sugar Acids
subclass of: PMO:00020901
MCID: MC00008478
PMOID: PMO:00016434
Subclass_of: Amino Sugars
Subclass_of: Sugar Acids
Synonym: Acids, Muramic
Synonym: Muramic Acids [Chemical/Ingredient]
Tree Number: T6.8.2.2
Tree Number: T6.8.8.5
database_cross_reference: MSH:D009112
database_cross_reference: NDFRT:N0000168486

Neuraminic Acids
type: Class
subclass of: Sugar Acids
subclass of: PMO:00020901
MCID: MC00008809
PMOID: PMO:00016435
Subclass_of: Amino Sugars
Subclass_of: Sugar Acids
Synonym: Acids, Neuraminic
Synonym: Neuraminic Acids [Chemical/Ingredient]
Tree Number: T6.8.2.3
Tree Number: T6.8.8.6
database_cross_reference: MSH:D009438
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008265

Sialic Acids
type: Class
subclass of: Neuraminic Acids
MCID: MC00011834
PMOID: PMO:00016436
Subclass_of: Neuraminic Acids
Synonym: ACETYLNEURAMINIC ACIDS N
Synonym: Acids, N-Acetylneuraminic
Synonym: Acids, Sialic
Synonym: N Acetylneuraminic Acids
Synonym: N-Acetylneuraminic Acids
Synonym: Sialic Acids [Chemical/Ingredient]
Synonym: Sialic acids
Tree Number: T6.8.2.3.1
Tree Number: T6.8.8.6.1
database_cross_reference: LCH:U004306
database_cross_reference: LCH_NW:sh85122186
database_cross_reference: MSH:D012794
database_cross_reference: NDFRT:N0000008088

Uronic Acids
type: Class
subclass of: Sugar Acids
subclass of: Acids, Aldehydic
MCID: MC00013399
PMOID: PMO:00016439
Subclass_of: Acids, Aldehydic
Subclass_of: Sugar Acids
Synonym: Acids, Uronic
Synonym: Uronic Acids [Chemical/Ingredient]
Synonym: Uronic acid
Synonym: Uronic acid (substance)
Synonym: Uronic acids
Tree Number: T6.2.12.2.2
Tree Number: T6.8.8.9
database_cross_reference: LCH:U004872
database_cross_reference: LCH_NW:sh85141454
database_cross_reference: MSH:D014574
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008256
database_cross_reference: SNMI:F-61116
database_cross_reference: SNOMEDCT_US:102641001

Glucuronates
type: Class
subclass of: Uronic Acids
MCID: MC00005690
PMOID: PMO:00016440
Subclass_of: Uronic Acids
Synonym: D-(+)-glucuronate
Synonym: D-glucuronate
Synonym: GCU
Synonym: Glucosiduronate
Synonym: Glucosiduronates
Synonym: Glucosiduronic acid
Synonym: Glucuronate
Synonym: Glucuronates [Chemical/Ingredient]
Synonym: alpha-D-glucopyranuronic acid
Synonym: alpha-D-glucuronic acid
Tree Number: T6.8.8.9.1
database_cross_reference: CHV:0000005579
database_cross_reference: CSP:2828-3716
database_cross_reference: DRUGBANK:DB03156
database_cross_reference: MSH:D005965
database_cross_reference: MTH:U001957
database_cross_reference: NDFRT:N0000168483

Hexuronic Acids
type: Class
subclass of: Uronic Acids
MCID: MC00006259
PMOID: PMO:00016443
Subclass_of: Uronic Acids
Synonym: Acids, Hexouronic
Synonym: Acids, Hexuronic
Synonym: Hexouronic Acids
Synonym: Hexuronic Acids [Chemical/Ingredient]
Tree Number: T6.8.8.9.2
database_cross_reference: MSH:D006603
database_cross_reference: NDFRT:N0000011366

2,3-Diketogulonic Acid
type: Class
subclass of: Sugar Acids
MCID: MC00000029
PMOID: PMO:00016445
Subclass_of: Sugar Acids
Synonym: 2,3 Diketogulonic Acid
Synonym: 2,3-Diketogulonic Acid [Chemical/Ingredient]
Synonym: Acid, 2,3-Diketogulonic
Synonym: DIKETOGULONIC ACID 02 03
Synonym: threo-2,3-Hexodiulosonic acid
Tree Number: T6.8.8.10
database_cross_reference: MSH:D015083
database_cross_reference: NDFRT:N0000168482

Tricarboxylic Acids
type: Class
subclass of: Acids, Acyclic
MCID: MC00013052
PMOID: PMO:00016446
Subclass_of: Acids, Acyclic
Synonym: Acids, Tricarboxylic
Synonym: Tricarboxylic Acids [Chemical/Ingredient]
Synonym: tricarboxylic acid
Tree Number: T6.2.12.1.12
database_cross_reference: AOD:0000020001
database_cross_reference: MSH:D014233
database_cross_reference: NDFRT:N0000008144

Valerates
type: Class
subclass of: Acids, Acyclic
subclass of: PMO:00021158
MCID: MC00013462
PMOID: PMO:00016453
Subclass_of: Acids, Acyclic
Subclass_of: Fatty Acids, Volatile
Synonym: Pentanoates
Synonym: Valerates [Chemical/Ingredient]
Synonym: valerate
Tree Number: T6.2.12.1.13
Tree Number: T6.9.3.6.5
database_cross_reference: AOD:0000019899
database_cross_reference: CHV:0000012881
database_cross_reference: LCH:U004892
database_cross_reference: LCH_NW:sh85141834
database_cross_reference: LNC:LP31727-8
database_cross_reference: MSH:D014631
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008150

Acids, Aldehydic
type: Class
subclass of: Carboxylic Acids
MCID: MC00000246
PMOID: PMO:00016457
Subclass_of: Carboxylic Acids
Synonym: Acids, Aldehydic [Chemical/Ingredient]
Synonym: Aldehydic Acids
Tree Number: T6.2.12.2
database_cross_reference: MSH:D000145
database_cross_reference: NDFRT:N0000008269

Glyoxylates
type: Class
subclass of: Acids, Aldehydic
MCID: MC00005779
PMOID: PMO:00016458
Subclass_of: Acids, Aldehydic
Synonym: Glyoxylate
Synonym: Glyoxylates [Chemical/Ingredient]
Synonym: glyoxylate
Tree Number: T6.2.12.2.1
database_cross_reference: CSP:4000-0328
database_cross_reference: LNC:LP18438-9
database_cross_reference: LNC:MTHU014316
database_cross_reference: MSH:D006038
database_cross_reference: MTH:U001965
database_cross_reference: NDFRT:N0000008220

Oxamic Acid
type: Class
subclass of: PMO:00021256
MCID: MC00009551
PMOID: PMO:00016459
Subclass_of: Amino Acids
Synonym: Acetic acid, aminooxo-
Synonym: Acid, Aminooxoacetic
Synonym: Acid, Oxalamic
Synonym: Acid, Oxamic
Synonym: Acid, Oxamidic
Synonym: Aminooxoacetic Acid
Synonym: Oxalamic Acid
Synonym: Oxamic Acid [Chemical/Ingredient]
Synonym: Oxamic acid
Synonym: Oxamic acid (substance)
Tree Number: T6.10.1.17
database_cross_reference: DRUGBANK:DB03940
database_cross_reference: MSH:D010072
database_cross_reference: NDFRT:N0000007829
database_cross_reference: SNM:F-11200
database_cross_reference: SNMI:F-61200
database_cross_reference: SNOMEDCT_US:46942006

Acids, Carbocyclic
type: Class
subclass of: Carboxylic Acids
MCID: MC00000247
PMOID: PMO:00016460
Subclass_of: Carboxylic Acids
Synonym: Acids, Carbocyclic [Chemical/Ingredient]
Synonym: Carbocyclic Acids
Synonym: carbocyclic acid
Tree Number: T6.2.12.3
database_cross_reference: AOD:0000028839
database_cross_reference: MSH:D000146
database_cross_reference: NDFRT:N0000007628

Benzoates
type: Class
subclass of: Acids, Carbocyclic
MCID: MC00001580
PMOID: PMO:00016461
Subclass_of: Acids, Carbocyclic
Synonym: Benzoates [Chemical/Ingredient]
Synonym: benzoate
Synonym: benzoates
Tree Number: T6.2.12.3.1
database_cross_reference: CHV:0000001791
database_cross_reference: CSP:2270-1307
database_cross_reference: LCH:U000537
database_cross_reference: LCH_NW:sh85013237
database_cross_reference: MSH:D001565
database_cross_reference: MTH:U001734
database_cross_reference: NDFRT:N0000005901

Adapalene, Benzoyl Peroxide Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00743583
PMOID: PMO:00016464
Subclass_of: Drug Combinations
Synonym: ADAPALENE/BENZOYL PEROXIDE
Synonym: Adapalene + benzoyl peroxide
Synonym: Adapalene + benzoyl peroxide (product)
Synonym: Adapalene - Benzoyl Peroxide Drug Combination
Synonym: Adapalene Benzoyl Peroxide Drug Combination
Synonym: Adapalene and Benzoyl Peroxide
Synonym: Adapalene, Benzoyl Peroxide Drug Combination [Chemical/Ingredient]
Synonym: Adapalene-Benzoyl Peroxide Drug Combination
Synonym: adapalene + benzoyl peroxide
Synonym: adapalene + benzoyl peroxide (medication)
Tree Number: T6.15.3.9
database_cross_reference: DRUGBANK:DB00210
database_cross_reference: DRUGBANK:DB09096
database_cross_reference: MEDCIN:304457
database_cross_reference: MSH:D000068801
database_cross_reference: NDFRT:N0000180559
database_cross_reference: NDFRT:N0000192005
database_cross_reference: RXNORM:859393
database_cross_reference: SNOMEDCT_US:442447008
database_cross_reference: VANDF:4029648

Metrizamide
type: Class
subclass of: PMO:00020951
MCID: MC00008263
PMOID: PMO:00016481
Subclass_of: Aminoglycosides
Synonym: D-Glucose, 2-((3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl)amino)-2-deoxy-
Synonym: METRIZAMIDE
Synonym: Metrizamide (product)
Synonym: Metrizamide (substance)
Synonym: Metrizamide [Chemical/Ingredient]
Synonym: metrizamide
Synonym: metrizamide (discontinued)
Synonym: metrizamide (discontinued) (procedure)
Tree Number: T6.8.6.1.6
database_cross_reference: ATC:V08AB01
database_cross_reference: DRUGBANK:DB01578
database_cross_reference: LCH:U002949
database_cross_reference: LCH_NW:sh85084446
database_cross_reference: MEDCIN:224697
database_cross_reference: MMSL:5104
database_cross_reference: MMSL:d01472
database_cross_reference: MSH:D008793
database_cross_reference: NCI:C66139
database_cross_reference: NCI_FDA:RHH3W8F1CO
database_cross_reference: NDDF:002350
database_cross_reference: NDFRT:N0000005775
database_cross_reference: NDFRT:N0000146557
database_cross_reference: RXNORM:6920
database_cross_reference: SNM:E-8155
database_cross_reference: SNMI:C-B0348
database_cross_reference: SNOMEDCT_US:414693007
database_cross_reference: SNOMEDCT_US:90733003
database_cross_reference: VANDF:4018226

Niflumic Acid
type: Class
subclass of: Nicotinic Acids
MCID: MC00008895
PMOID: PMO:00016504
Subclass_of: Nicotinic Acids
Synonym: 3-Pyridinecarboxylic acid, 2-((3-(trifluoromethyl)phenyl)amino)-
Synonym: Acid, Niflumic
Synonym: Acide niflumique
Synonym: Acido niflumico
Synonym: Acidum niflumicum
Synonym: NFA
Synonym: NIFLUMIC ACID
Synonym: Niflam
Synonym: Niflumic Acid [Chemical/Ingredient]
Synonym: niflumic acid
Tree Number: T6.3.2.5.7
database_cross_reference: ATC:M01AX02
database_cross_reference: ATC:M02AA17
database_cross_reference: CHV:0000008714
database_cross_reference: DRUGBANK:DB04552
database_cross_reference: MSH:D009544
database_cross_reference: NCI:C76807
database_cross_reference: NCI_FDA:4U5MP5IUD8
database_cross_reference: NDDF:005830
database_cross_reference: NDFRT:N0000167326
database_cross_reference: RXNORM:7418

Hydroxybenzoates
type: Class
subclass of: Hydroxy Acids
MCID: MC00066719
PMOID: PMO:00016507
Subclass_of: Hydroxy Acids
Synonym: Hydroxybenzoate
Synonym: Hydroxybenzoates [Chemical/Ingredient]
Synonym: hydroxybenzoate
Synonym: hydroxybenzoates
Tree Number: T6.2.12.6.14
database_cross_reference: CHV:0000018350
database_cross_reference: CSP:2270-1982
database_cross_reference: LNC:LP36601-0
database_cross_reference: MSH:D062385
database_cross_reference: NDFRT:N0000185640

Hydroxybenzoate Ethers
type: Class
subclass of: Phenyl Ethers
MCID: MC00909536
PMOID: PMO:00016519
Subclass_of: Phenyl Ethers
Synonym: Ethers, Hydroxybenzoate
Synonym: Hydroxybenzoate Ethers [Chemical/Ingredient]
Tree Number: T6.2.14.7.8
database_cross_reference: MSH:D062425
database_cross_reference: NDFRT:N0000185689

Cinnamates
type: Class
subclass of: Acids, Carbocyclic
MCID: MC00002910
PMOID: PMO:00016523
Subclass_of: Acids, Carbocyclic
Synonym: Cinnamates [Chemical/Ingredient]
Synonym: cinnamate
Synonym: cinnamates
Tree Number: T6.2.12.3.2
database_cross_reference: CHV:0000002998
database_cross_reference: CSP:2270-0872
database_cross_reference: LCH:U001028
database_cross_reference: LCH_NW:sh86006849
database_cross_reference: MSH:D002934
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008060

Puromycin
type: Class
subclass of: PMO:00020951
MCID: MC00010934
PMOID: PMO:00016529
Subclass_of: Aminoglycosides
Synonym: Adenosine, 3'-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyl-, (S)-
Synonym: Adenosine, 3'-(alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl-, L-
Synonym: L-3'-(alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine
Synonym: PUROMYCIN
Synonym: Puromicina
Synonym: Puromycin [Chemical/Ingredient]
Synonym: Puromycine
Synonym: Puromycinum
Synonym: puromycin
Tree Number: T6.8.6.1.8
database_cross_reference: CSP:0206-4046
database_cross_reference: DRUGBANK:DB08437
database_cross_reference: LCH:U003957
database_cross_reference: LCH_NW:sh85109203
database_cross_reference: MSH:D011691
database_cross_reference: NCI:C787
database_cross_reference: NCI_DCP:07447
database_cross_reference: NCI_DTP:NSC0003055
database_cross_reference: NCI_FDA:4A6ZS6Q2CL
database_cross_reference: NDFRT:N0000170627
database_cross_reference: PSY:42390

Cyclohexanecarboxylic Acids
type: Class
subclass of: Acids, Carbocyclic
MCID: MC00003413
PMOID: PMO:00016531
Subclass_of: Acids, Carbocyclic
Synonym: Acids, Cyclohexanecarboxylic
Synonym: Cyclohexanecarboxylic Acids [Chemical/Ingredient]
Tree Number: T6.2.12.3.3
database_cross_reference: MSH:D003509
database_cross_reference: NDFRT:N0000007887

Quinic Acid
type: Class
subclass of: Hydroxy Acids
MCID: MC00011062
PMOID: PMO:00016536
Subclass_of: Hydroxy Acids
Synonym: Acid, Quinic
Synonym: Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, (1R-(1alpha,3alpha,4alpha,5beta))-
Synonym: QUINIC ACID
Synonym: Quinic Acid [Chemical/Ingredient]
Tree Number: T6.2.12.6.11
database_cross_reference: MSH:D011801
database_cross_reference: MTHSPL:058C04BGYI
database_cross_reference: NDFRT:N0000166670
database_cross_reference: RXNORM:1427232

Shikimic Acid
type: Class
subclass of: Hydroxy Acids
MCID: MC00011818
PMOID: PMO:00016537
Subclass_of: Hydroxy Acids
Synonym: 1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R-(3alpha,4alpha,5beta))-
Synonym: Acid, Shikimic
Synonym: Shikimic Acid [Chemical/Ingredient]
Synonym: Shikimic acid
Tree Number: T6.2.12.6.12
database_cross_reference: LCH:U004297
database_cross_reference: LCH_NW:sh86002803
database_cross_reference: MSH:D012765
database_cross_reference: NDFRT:N0000166685

Mandelic Acids
type: Class
subclass of: Acids, Carbocyclic
subclass of: Hydroxy Acids
MCID: MC00007877
PMOID: PMO:00016540
Subclass_of: Acids, Carbocyclic
Subclass_of: Hydroxy Acids
Synonym: (2R)-2-hydroxy-2-phenylacetic acid
Synonym: (R)-2-Hydroxy-2-phenylacetic acid
Synonym: (R)-Mandelic acid
Synonym: (R)-α-hydroxybenzeneacetic acid
Synonym: (R)-α-hydroxyphenylacetic acid
Synonym: (−)-(R)-mandelic acid
Synonym: (−)-mandelic acid
Synonym: (−)-α-hydroxyphenylacetic acid
Synonym: Acids, Mandelic
Synonym: D(−)-mandelic acid
Tree Number: T6.2.12.3.4
Tree Number: T6.2.12.6.7
database_cross_reference: DRUGBANK:DB02280
database_cross_reference: MSH:D008333
database_cross_reference: NDFRT:N0000008084

Phenylacetates
type: Class
subclass of: Acids, Carbocyclic
MCID: MC00010036
PMOID: PMO:00016543
Subclass_of: Acids, Carbocyclic
Synonym: Benzeneacetates
Synonym: Phenylacetates [Chemical/Ingredient]
Synonym: phenylacetate
Synonym: phenylacetates
Tree Number: T6.2.12.3.5
database_cross_reference: AOD:0000019989
database_cross_reference: CHV:0000009609
database_cross_reference: CSP:2266-1995
database_cross_reference: LCH_NW:sh96008818
database_cross_reference: MSH:D010648
database_cross_reference: MTH:U002161
database_cross_reference: NDFRT:N0000007551

Benzilates
type: Class
subclass of: Hydroxy Acids
MCID: MC00001577
PMOID: PMO:00016547
Subclass_of: Hydroxy Acids
Synonym: Benzilates [Chemical/Ingredient]
Synonym: benzilate
Tree Number: T6.2.12.6.1
database_cross_reference: AOD:0000019938
database_cross_reference: CHV:0000001789
database_cross_reference: CSP:2270-1307
database_cross_reference: MSH:D001561
database_cross_reference: NDFRT:N0000007535

Quinuclidinyl Benzilate
type: Class
subclass of: Quinuclidines
MCID: MC00011082
PMOID: PMO:00016549
Subclass_of: Quinuclidines
Synonym: Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 1-azabicyclo(2.2.2)oct-3-yl ester
Synonym: Benzilate, Quinuclidinyl
Synonym: Quinuclidinyl Benzilate [Chemical/Ingredient]
Synonym: quinuclidinyl benzilate
Tree Number: T6.3.4.3.4
database_cross_reference: AOD:0000019940
database_cross_reference: MSH:D011813
database_cross_reference: NDFRT:N0000007741

Methylphenidate
type: Class
subclass of: Piperidines
MCID: MC00008243
PMOID: PMO:00016552
Subclass_of: Piperidines
Synonym: 2-Piperidineacetic acid, alpha-phenyl-, methyl ester
Synonym: Apo-methylphenidate
Synonym: Apo-methylphenidate ER
Synonym: Apo-methylphenidate SR
Synonym: Biphentin
Synonym: Cotempla XR-ODT
Synonym: Equasym XL
Synonym: METHYLPHENIDATE
Synonym: MPH
Synonym: Medikinet XL
Tree Number: T6.3.5.16.17
database_cross_reference: AOD:0000019942
database_cross_reference: ATC:N06BA04
database_cross_reference: CHV:0000008064
database_cross_reference: CSP:2332-4330
database_cross_reference: DRUGBANK:DB00422
database_cross_reference: LCH_NW:sh91001552
database_cross_reference: LNC:LP16202-1
database_cross_reference: LNC:MTHU008754
database_cross_reference: MEDCIN:340443
database_cross_reference: MMSL:d00900
database_cross_reference: MSH:D008774
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:207ZZ9QZ49
database_cross_reference: NCI:C62045
database_cross_reference: NCI_FDA:207ZZ9QZ49
database_cross_reference: NDDF:004619
database_cross_reference: NDFRT:N0000005717
database_cross_reference: NDFRT:N0000147920
database_cross_reference: PDQ:CDR0000041225
database_cross_reference: PSY:31210
database_cross_reference: RCD:dw1..
database_cross_reference: RXNORM:6901
database_cross_reference: SNM:E-7731
database_cross_reference: SNMI:C-65520
database_cross_reference: SNOMEDCT_US:18548003
database_cross_reference: SNOMEDCT_US:373337007
database_cross_reference: USPMG:MTHU001089
database_cross_reference: VANDF:4019832

Phenylbutyrates
type: Class
subclass of: Acids, Carbocyclic
MCID: MC00010042
PMOID: PMO:00016555
Subclass_of: Acids, Carbocyclic
Synonym: Phenylbutyrate
Synonym: Phenylbutyrates [Chemical/Ingredient]
Synonym: phenylbutyrate
Tree Number: T6.2.12.3.6
database_cross_reference: CHV:0000009613
database_cross_reference: CSP:5000-0015
database_cross_reference: DRUGBANK:DB06819
database_cross_reference: MSH:D010654
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000005961

Phenylpropionates
type: Class
subclass of: Acids, Carbocyclic
MCID: MC00010057
PMOID: PMO:00016556
Subclass_of: Acids, Carbocyclic
Synonym: Phenylpropionates [Chemical/Ingredient]
Synonym: phenylpropionate
Synonym: phenylpropionates
Tree Number: T6.2.12.3.7
database_cross_reference: CHV:0000009620
database_cross_reference: MSH:D010666
database_cross_reference: NDFRT:N0000007564

Phenylpyruvic Acids
type: Class
subclass of: Acids, Carbocyclic
MCID: MC00010059
PMOID: PMO:00016562
Subclass_of: Acids, Carbocyclic
Synonym: Acids, Phenylpyruvic
Synonym: Phenylpyruvic Acids [Chemical/Ingredient]
Synonym: Phenylpyruvic acid
Synonym: phenylpyruvic acid
Tree Number: T6.2.12.3.8
database_cross_reference: DRUGBANK:DB03884
database_cross_reference: MSH:D010667
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:014395
database_cross_reference: NDFRT:N0000166687

Phthalic Acids
type: Class
subclass of: Acids, Carbocyclic
MCID: MC00010177
PMOID: PMO:00016563
Subclass_of: Acids, Carbocyclic
Synonym: Acids, Phthalic
Synonym: Phthalic Acids [Chemical/Ingredient]
Tree Number: T6.2.12.3.9
database_cross_reference: MSH:D010795
database_cross_reference: NDFRT:N0000008186

Phthalimides
type: Class
subclass of: Imides
MCID: MC00010179
PMOID: PMO:00016566
Subclass_of: Imides
Synonym: Phthalimides [Chemical/Ingredient]
Synonym: phthalimide
Synonym: phthalimides
Tree Number: T6.2.18.4
database_cross_reference: CHV:0000009695
database_cross_reference: CSP:0397-5785
database_cross_reference: MSH:D010797
database_cross_reference: MTH:U002166
database_cross_reference: NDFRT:N0000007753

Esters
type: Class
subclass of: Carboxylic Acids
MCID: MC00004728
PMOID: PMO:00016568
Subclass_of: Carboxylic Acids
Synonym: Ester
Synonym: Ester (substance)
Synonym: Ester, NOS
Synonym: Esters [Chemical/Ingredient]
Synonym: Organic Ester
Synonym: ester
Synonym: esters
Tree Number: T6.2.12.4
database_cross_reference: AOD:0000018269
database_cross_reference: CHV:0000004670
database_cross_reference: CSP:1064-4259
database_cross_reference: LCH:U001663
database_cross_reference: LCH_NW:sh85044949
database_cross_reference: LNC:LP21220-6
database_cross_reference: LNC:LP21224-8
database_cross_reference: MSH:D004952
database_cross_reference: NCI:C94712
database_cross_reference: NCI_NCI-GLOSS:CDR0000463104
database_cross_reference: NDFRT:N0000166743
database_cross_reference: RCD:Xa85l
database_cross_reference: SNMI:C-10048
database_cross_reference: SNOMEDCT_US:45120003

Humic Substances
type: Class
subclass of: Carboxylic Acids
subclass of: PMO:00024235
MCID: MC00516314
PMOID: PMO:00016569
Subclass_of: Carboxylic Acids
Subclass_of: Soil
Synonym: Humic Substances [Chemical/Ingredient]
Synonym: Substances, Humic
Tree Number: T6.12.9.1
Tree Number: T6.2.12.5
database_cross_reference: MSH:D006812
database_cross_reference: NDFRT:N0000166639

Hydroxy Acids
type: Class
subclass of: Carboxylic Acids
MCID: MC00006483
PMOID: PMO:00016570
Subclass_of: Carboxylic Acids
Synonym: Acids, Hydroxy
Synonym: Hydroxy Acids [Chemical/Ingredient]
Synonym: Hydroxy acids
Synonym: acid hydroxy
Synonym: hydroxy acids
Synonym: hydroxyacid
Tree Number: T6.2.12.6
database_cross_reference: AOD:0000019933
database_cross_reference: CHV:0000006373
database_cross_reference: CSP:0562-8365
database_cross_reference: LCH_NW:sh97005617
database_cross_reference: MSH:D006880
database_cross_reference: NDFRT:N0000007983

Lactates
type: Class
subclass of: Hydroxy Acids
MCID: MC00007331
PMOID: PMO:00016571
Subclass_of: Hydroxy Acids
Synonym: Lactates [Chemical/Ingredient]
Synonym: lactate
Synonym: lactates
Tree Number: T6.2.12.6.5
database_cross_reference: CHV:0000007182
database_cross_reference: CSP:1129-3175
database_cross_reference: LCH_NW:sh94005186
database_cross_reference: MSH:D007773
database_cross_reference: MTH:U002031
database_cross_reference: NDFRT:N0000006568

Mevalonic Acid
type: Class
subclass of: Hydroxy Acids
MCID: MC00008268
PMOID: PMO:00016574
Subclass_of: Hydroxy Acids
Synonym: (R)-3,5-dihydroxy-3-methylvaleric acid
Synonym: (R)-mevalonate
Synonym: (R)-mevalonic acid
Synonym: 3,5-Dihydroxy-3-methylvaleric acid
Synonym: Acid, Mevalonic
Synonym: Mevalonic Acid [Chemical/Ingredient]
Synonym: Mevalonic acid
Synonym: Mevalonic acid (substance)
Synonym: Pentanoic acid, 3,5-dihydroxy-3-methyl-
Synonym: mevalonic acid
Tree Number: T6.2.12.6.8
database_cross_reference: CHV:0000008076
database_cross_reference: DRUGBANK:DB03518
database_cross_reference: LCH:U002951
database_cross_reference: LCH_NW:sh85084470
database_cross_reference: MSH:D008798
database_cross_reference: NDFRT:N0000166679
database_cross_reference: SNOMEDCT_US:115390008

Mycolic Acids
type: Class
subclass of: Hydroxy Acids
subclass of: PMO:00021087
MCID: MC00008521
PMOID: PMO:00016575
Subclass_of: Fatty Acids
Subclass_of: Hydroxy Acids
Synonym: Acids, Mycolic
Synonym: Mycolic Acids [Chemical/Ingredient]
Synonym: mycolic acid
Tree Number: T6.2.12.6.9
Tree Number: T6.9.3.10
database_cross_reference: CSP:1129-3019
database_cross_reference: MSH:D009171
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168562

Phosphoenolpyruvate
type: Class
subclass of: Hydroxy Acids
MCID: MC00010118
PMOID: PMO:00016576
Subclass_of: Hydroxy Acids
Synonym: 2-Propenoic acid, 2-(phosphonooxy)-, ion(1-)
Synonym: PEP
Synonym: Phosphoenolpyruvate [Chemical/Ingredient]
Synonym: pep
Synonym: phosphoenolpyruvate
Synonym: phosphoenolpyruvate (PEP)
Tree Number: T6.2.12.6.10
database_cross_reference: AOD:0000018377
database_cross_reference: CHV:0000009662
database_cross_reference: CSP:1129-3731
database_cross_reference: DRUGBANK:DB01819
database_cross_reference: MSH:D010728
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166677

Keto Acids
type: Class
subclass of: Carboxylic Acids
MCID: MC00007223
PMOID: PMO:00016577
Subclass_of: Carboxylic Acids
Synonym: Acids, Keto
Synonym: Acids, Oxo
Synonym: Keto Acids [Chemical/Ingredient]
Synonym: Keto acids
Synonym: Ketoacid
Synonym: Ketoacid (substance)
Synonym: Ketoacid, NOS
Synonym: Oxo Acids
Synonym: Oxoacid
Synonym: Oxoacids
Tree Number: T6.2.12.7
database_cross_reference: AOD:0000019944
database_cross_reference: CHV:0000007075
database_cross_reference: CSP:0562-9513
database_cross_reference: LNC:LP31728-6
database_cross_reference: MSH:D007651
database_cross_reference: NDFRT:N0000008264
database_cross_reference: SNM:F-14240
database_cross_reference: SNMI:F-64040
database_cross_reference: SNOMEDCT_US:88020002

Acetoacetates
type: Class
subclass of: Keto Acids
subclass of: Ketone Bodies
MCID: MC00000183
PMOID: PMO:00016578
Subclass_of: Keto Acids
Subclass_of: Ketone Bodies
Synonym: Acetoacetate
Synonym: Acetoacetates [Chemical/Ingredient]
Synonym: acetoacetate
Tree Number: T6.2.12.7.1
Tree Number: T6.2.20.9.1
database_cross_reference: CHV:0000000607
database_cross_reference: CSP:1129-2395
database_cross_reference: LNC:LP15312-9
database_cross_reference: LNC:LP70346-9
database_cross_reference: LNC:MTHU007082
database_cross_reference: MSH:D000090
database_cross_reference: MTH:U001659
database_cross_reference: NDFRT:N0000166790

Levulinic Acids
type: Class
subclass of: Keto Acids
MCID: MC00007544
PMOID: PMO:00016579
Subclass_of: Keto Acids
Synonym: Acids, Levulinic
Synonym: Laevulinic Acid
Synonym: Levulinic Acids [Chemical/Ingredient]
Tree Number: T6.2.12.7.4
database_cross_reference: DRUGBANK:DB02239
database_cross_reference: MSH:D007982
database_cross_reference: NDFRT:N0000008003

Aminolevulinic Acid
type: Class
subclass of: PMO:00021256
MCID: MC00000764
PMOID: PMO:00016580
Subclass_of: Amino Acids
Synonym: 5 aminolevulinic acid
Synonym: 5-ALA
Synonym: 5-Amino-4-oxopentanoic Acid
Synonym: 5-Amino-4-oxovaleric acid
Synonym: 5-Aminolaevulinic Acid
Synonym: 5-Aminolaevulinic acid
Synonym: 5-Aminolevulinic Acid
Synonym: 5-Aminolevulinic acid
Synonym: 5-Aminolevulinic acid (product)
Synonym: 5-Aminolevulinic acid (substance)
Tree Number: T6.10.1.11
database_cross_reference: AOD:0000019950
database_cross_reference: ATC:L01XD04
database_cross_reference: CHV:0000001017
database_cross_reference: DRUGBANK:DB00855
database_cross_reference: MSH:D000622
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:88755TAZ87
database_cross_reference: NCI:C234
database_cross_reference: NCI_FDA:88755TAZ87
database_cross_reference: NCI_NCI-GLOSS:CDR0000045532
database_cross_reference: NDFRT:N0000170216
database_cross_reference: NDFRT:N0000176068
database_cross_reference: PDQ:CDR0000042648
database_cross_reference: RCD:X80L1
database_cross_reference: RXNORM:683
database_cross_reference: SNM:F-14810
database_cross_reference: SNMI:F-64810
database_cross_reference: SNOMEDCT_US:115458002
database_cross_reference: SNOMEDCT_US:259496005
database_cross_reference: SNOMEDCT_US:409398000
database_cross_reference: SNOMEDCT_US:72677001
database_cross_reference: VANDF:4025779

Pyruvates
type: Class
subclass of: Keto Acids
MCID: MC00011051
PMOID: PMO:00016581
Subclass_of: Keto Acids
Synonym: Pyruvates [Chemical/Ingredient]
Synonym: pyruvate
Synonym: pyruvates
Tree Number: T6.2.12.7.6
database_cross_reference: CHV:0000010473
database_cross_reference: CSP:1129-3692
database_cross_reference: LCH:U003979
database_cross_reference: LCH_NW:sh85109370
database_cross_reference: MSH:D011773
database_cross_reference: MTH:U002212
database_cross_reference: NDFRT:N0000166686

Thioctic Acid
type: Class
subclass of: Carboxylic Acids
subclass of: Thiophenes
subclass of: Coenzymes
subclass of: PMO:00021087
MCID: MC00007600
PMOID: PMO:00016583
Subclass_of: Carboxylic Acids
Subclass_of: Coenzymes
Subclass_of: Fatty Acids
Subclass_of: Thiophenes
Synonym: (+)-alpha-Lipoic acid
Synonym: (R)-(+)-Lipoate
Synonym: (R)-1,2-Dithiolane-3-pentanoic acid
Synonym: (R)-1,2-dithiolane-3-valeric acid
Synonym: (R)-6,8-thioctic acid
Synonym: .ALPHA.-LIPOIC ACID
Synonym: .ALPHA.-LIPOIC ACID, (+/-)-
Synonym: .Alpha.-Lipoic Acid
Synonym: .alpha.-lipoic Acid
Synonym: .alpha.-lipoic acid
Tree Number: T6.2.12.8
Tree Number: T6.2.32.22.7
Tree Number: T6.7.1.6
Tree Number: T6.9.3.9
database_cross_reference: AOD:0000018231
database_cross_reference: ATC:A16AX01
database_cross_reference: CHV:0000007460
database_cross_reference: DRUGBANK:DB00166
database_cross_reference: LCH_NW:sh96009518
database_cross_reference: MEDCIN:199525
database_cross_reference: MMSL:107951
database_cross_reference: MMSL:23416
database_cross_reference: MMSL:NOCODE
database_cross_reference: MMSL:d06655
database_cross_reference: MSH:D008063
database_cross_reference: MTHSPL:73Y7P0K73Y
database_cross_reference: NCI:C61595
database_cross_reference: NCI_DCP:03352
database_cross_reference: NCI_FDA:73Y7P0K73Y
database_cross_reference: NCI_NCI-GLOSS:CDR0000443026
database_cross_reference: NDDF:006470
database_cross_reference: NDFRT:N0000010560
database_cross_reference: NDFRT:N0000148846
database_cross_reference: NDFRT:N0000148863
database_cross_reference: PDQ:CDR0000440740
database_cross_reference: RXNORM:6417
database_cross_reference: SNMI:F-630A0
database_cross_reference: SNOMEDCT_US:70496003
database_cross_reference: SNOMEDCT_US:715405004
database_cross_reference: VANDF:4021443
database_cross_reference: VANDF:4021484

Cyanates
type: Class
subclass of: Organic Chemicals
MCID: MC00003385
PMOID: PMO:00016584
Subclass_of: Organic Chemicals
Synonym: Cyanates [Chemical/Ingredient]
Synonym: cyanate
Tree Number: T6.2.13
database_cross_reference: CSP:0774-1109
database_cross_reference: LCH_NW:sh2007003844
database_cross_reference: MSH:D003485
database_cross_reference: NDFRT:N0000166620

Thiocyanates
type: Class
subclass of: Sulfur Compounds
subclass of: Cyanates
MCID: MC00012729
PMOID: PMO:00016585
Subclass_of: Cyanates
Subclass_of: Sulfur Compounds
Synonym: Rhodanates
Synonym: Thiocyanates [Chemical/Ingredient]
Synonym: thiocyanate
Synonym: thiocyanates
Tree Number: T6.2.13.1
Tree Number: T6.2.32.17
database_cross_reference: CHV:0000012186
database_cross_reference: CSP:2904-6484
database_cross_reference: LCH:U004653
database_cross_reference: LCH_NW:sh85134880
database_cross_reference: MSH:D013861
database_cross_reference: MTH:U002297
database_cross_reference: NDFRT:N0000166621

Ethers
type: Class
subclass of: Organic Chemicals
MCID: MC00004769
PMOID: PMO:00016586
Subclass_of: Organic Chemicals
Synonym: 1,1'-Oxybisethane
Synonym: 212 ETHERS
Synonym: ETHER
Synonym: ETHERS
Synonym: Ether
Synonym: Ether, NOS
Synonym: Ethers [Chemical/Ingredient]
Synonym: Ethyl Ether
Synonym: ether
Synonym: ethers
Tree Number: T6.2.14
database_cross_reference: AOD:0000019693
database_cross_reference: CHV:0000004691
database_cross_reference: CSP:1068-9211
database_cross_reference: LCH:U001673
database_cross_reference: LCH_NW:sh85045088
database_cross_reference: MSH:D004987
database_cross_reference: MTH:U001909
database_cross_reference: NCI:C29819
database_cross_reference: NCI_DCP:04580
database_cross_reference: NCI_FDA:0F5N573A2Y
database_cross_reference: NDFRT:N0000008201
database_cross_reference: RCD:X79OD
database_cross_reference: SNM:E-5590
database_cross_reference: SNM:U000136
database_cross_reference: SNMI:C-21200

Acetals
type: Class
subclass of: Ethers
MCID: MC00000170
PMOID: PMO:00016587
Subclass_of: Ethers
Synonym: ACETAL
Synonym: Acetal
Synonym: Acetal (substance)
Synonym: Acetals [Chemical/Ingredient]
Synonym: acetal
Tree Number: T6.2.14.1
database_cross_reference: CHV:0000000599
database_cross_reference: CSP:1672-1675
database_cross_reference: MSH:D000080
database_cross_reference: NCI:C83515
database_cross_reference: NCI_FDA:5G14F9E2HB
database_cross_reference: NDFRT:N0000166636
database_cross_reference: SNM:E-5631
database_cross_reference: SNMI:C-21409
database_cross_reference: SNOMEDCT_US:72802008

Ethers, Cyclic
type: Class
subclass of: Ethers
subclass of: Macrocyclic Compounds
MCID: MC00004770
PMOID: PMO:00016588
Subclass_of: Ethers
Subclass_of: Macrocyclic Compounds
Synonym: Cyclic Ethers
Synonym: Ethers, Cyclic [Chemical/Ingredient]
Tree Number: T6.2.14.2
Tree Number: T6.4.5.3
database_cross_reference: MSH:D004988
database_cross_reference: NDFRT:N0000008202

Ciguatoxins
type: Class
subclass of: Ethers, Cyclic
subclass of: PMO:00024388
MCID: MC00002902
PMOID: PMO:00016589
Subclass_of: Ethers, Cyclic
Subclass_of: Marine Toxins
Synonym: Ciguatoxin
Synonym: Ciguatoxin (substance)
Synonym: Ciguatoxins [Chemical/Ingredient]
Synonym: ciguatoxin
Tree Number: T6.13.8.5.1
Tree Number: T6.2.14.2.1
database_cross_reference: CSP:4008-0106
database_cross_reference: MSH:D002922
database_cross_reference: NDFRT:N0000171398
database_cross_reference: RCD:Xa9Sd
database_cross_reference: SNM:E-6972
database_cross_reference: SNMI:C-34005
database_cross_reference: SNOMEDCT_US:26426004

Epoxy Compounds
type: Class
subclass of: Ethers, Cyclic
MCID: MC00004631
PMOID: PMO:00016590
Subclass_of: Ethers, Cyclic
Synonym: Compounds, Epoxy
Synonym: EPOXY CPDS
Synonym: Epoxides
Synonym: Epoxy Compounds [Chemical/Ingredient]
Synonym: Epoxy compounds
Synonym: Oxiranes
Synonym: epoxide
Synonym: epoxides
Tree Number: T6.2.14.2.2
database_cross_reference: CHV:0000004583
database_cross_reference: CSP:2166-0308
database_cross_reference: LCH:U001635
database_cross_reference: LCH_NW:sh85044476
database_cross_reference: MSH:D004852
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007613

Ethoglucid
type: Class
subclass of: Ethers
MCID: MC00004781
PMOID: PMO:00016592
Subclass_of: Ethers
Synonym: 1,2-Bis[2-(2, 3-epoxypropoxy)ethoxy]ethane
Synonym: 1,2-bis[2-(2,3-epoxypropoxy)ethoxy]ethane
Synonym: 1,2:15,16-Diepoxy-4,7,10, 13-tetraoxahexadecane
Synonym: 1,2:15,16-diepoxy-4,7,10,13-tetraoxahexadecane
Synonym: 2,2'-(2,5,8,11-tetraoxadodecane-1,12-diyl)bisoxirane
Synonym: ETOG
Synonym: ETOGLUCID
Synonym: Ethane, 1, 2-bis[2-(2,3-epoxypropoxy)ethoxy]-
Synonym: Ethoglucid (product)
Synonym: Ethoglucid (substance)
Tree Number: T6.2.14.3
database_cross_reference: ATC:L01AG01
database_cross_reference: MSH:D005009
database_cross_reference: NCI:C489
database_cross_reference: NCI_DTP:NSC0080439
database_cross_reference: NCI_FDA:4F9KUA0T4D
database_cross_reference: NDDF:003715
database_cross_reference: NDFRT:N0000166635
database_cross_reference: PDQ:CDR0000039233
database_cross_reference: RCD:h16..
database_cross_reference: RXNORM:4132
database_cross_reference: SNOMEDCT_US:326748008
database_cross_reference: SNOMEDCT_US:419766000

Mupirocin
type: Class
subclass of: Pyrans
subclass of: PMO:00021087
MCID: MC00043241
PMOID: PMO:00016595
Subclass_of: Fatty Acids
Subclass_of: Pyrans
Synonym: 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid
Synonym: Acid, Pseudomonic
Synonym: Bactroban Cream
Synonym: Bactroban Nasal
Synonym: Bactroban Nasal Ointment
Synonym: Centany AT
Synonym: MUPIROCIN
Synonym: Mupirocin (product)
Synonym: Mupirocin (substance)
Synonym: Mupirocin 2%
Tree Number: T6.3.5.17.8
Tree Number: T6.9.3.17
database_cross_reference: ATC:D06AX09
database_cross_reference: ATC:R01AX06
database_cross_reference: CHV:0000015522
database_cross_reference: DRUGBANK:DB00410
database_cross_reference: LCH_NW:sh85088527
database_cross_reference: LNC:LP17279-8
database_cross_reference: LNC:MTHU009172
database_cross_reference: MEDCIN:48552
database_cross_reference: MMSL:47751
database_cross_reference: MMSL:5138
database_cross_reference: MSH:D016712
database_cross_reference: MTHSPL:D0GX863OA5
database_cross_reference: NCI:C29271
database_cross_reference: NCI_FDA:D0GX863OA5
database_cross_reference: NDDF:002802
database_cross_reference: NDFRT:N0000007274
database_cross_reference: NDFRT:N0000147519
database_cross_reference: RCD:mc5..
database_cross_reference: RXNORM:42372
database_cross_reference: SNMI:C-90660
database_cross_reference: SNOMEDCT_US:387397004
database_cross_reference: SNOMEDCT_US:71453003
database_cross_reference: USPMG:MTHU001116
database_cross_reference: VANDF:4019345

Oxepins
type: Class
subclass of: Ethers, Cyclic
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00009561
PMOID: PMO:00016596
Subclass_of: Ethers, Cyclic
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Oxepene
Synonym: Oxepenes
Synonym: Oxepin
Synonym: Oxepins [Chemical/Ingredient]
Synonym: oxepin
Tree Number: T6.2.14.2.3
Tree Number: T6.3.5.14
database_cross_reference: CSP:2188-5123
database_cross_reference: LCH_NW:sh2007002601
database_cross_reference: MSH:D010082
database_cross_reference: NDFRT:N0000011425

Okadaic Acid
type: Class
subclass of: Ethers, Cyclic
MCID: MC00033749
PMOID: PMO:00016598
Subclass_of: Ethers, Cyclic
Synonym: Acid, Ocadaic
Synonym: Acid, Okadaic
Synonym: OKA
Synonym: Ocadaic Acid
Synonym: Okadaic Acid [Chemical/Ingredient]
Synonym: Okadaic acid
Synonym: Okadaic acid (substance)
Synonym: oka
Synonym: okadaic acid
Tree Number: T6.2.14.2.4
database_cross_reference: CHV:0000014535
database_cross_reference: CSP:4001-0096
database_cross_reference: MSH:D019319
database_cross_reference: NDFRT:N0000166628
database_cross_reference: RCD:Xa3db
database_cross_reference: SNOMEDCT_US:286859001

Oxocins
type: Class
subclass of: Ethers, Cyclic
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00377833
PMOID: PMO:00016599
Subclass_of: Ethers, Cyclic
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Oxocenes
Synonym: Oxocins [Chemical/Ingredient]
Tree Number: T6.2.14.2.5
Tree Number: T6.3.5.27
database_cross_reference: MSH:D035964
database_cross_reference: NDFRT:N0000167167

Crown Ethers
type: Class
subclass of: Ethers, Cyclic
subclass of: Crown Compounds
MCID: MC00023742
PMOID: PMO:00016600
Subclass_of: Crown Compounds
Subclass_of: Ethers, Cyclic
Synonym: Crown Ethers [Chemical/Ingredient]
Synonym: Crown ethers
Synonym: Ethers, Crown
Synonym: crown ether
Synonym: crown ethers
Tree Number: T6.2.14.2.6
Tree Number: T6.4.5.3.1
Tree Number: T6.4.5.8.1
database_cross_reference: CHV:0000013806
database_cross_reference: LCH_NW:sh89006653
database_cross_reference: MSH:D043844
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167396

Ethyl Ethers
type: Class
subclass of: Ethers
MCID: MC00004791
PMOID: PMO:00016601
Subclass_of: Ethers
Synonym: Ethers, Ethyl
Synonym: Ethyl Ethers [Chemical/Ingredient]
Tree Number: T6.2.14.4
database_cross_reference: MSH:D005019
database_cross_reference: NDFRT:N0000008007

Ether
type: Class
subclass of: Ethyl Ethers
MCID: MC00004768
PMOID: PMO:00016602
Subclass_of: Ethyl Ethers
Synonym: Diethyl Ether
Synonym: Diethyl ether
Synonym: ETHER
Synonym: ETHER [VA Product]
Synonym: Ethane, 1,1'-oxybis-
Synonym: Ether (substance)
Synonym: Ether [Chemical/Ingredient]
Synonym: Ether solvent
Synonym: Ether, Diethyl
Synonym: Ether, Ethyl
Tree Number: T6.2.14.4.1
database_cross_reference: CHV:0000004690
database_cross_reference: CSP:1068-9211
database_cross_reference: LCH:U001672
database_cross_reference: LCH_NW:sh85045081
database_cross_reference: LNC:LP15535-5
database_cross_reference: LNC:MTHU004530
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D004986
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:0F5N573A2Y
database_cross_reference: NDDF:001392
database_cross_reference: NDDF:002461
database_cross_reference: NDFRT:N0000007330
database_cross_reference: NDFRT:N0000037309
database_cross_reference: NDFRT:N0000157724
database_cross_reference: RCD:X80A2
database_cross_reference: RCD:mr1..
database_cross_reference: RXNORM:1363043
database_cross_reference: SNOMEDCT_US:259170003
database_cross_reference: SNOMEDCT_US:333509007
database_cross_reference: SNOMEDCT_US:3601005
database_cross_reference: SNOMEDCT_US:56281006
database_cross_reference: VANDF:4009769
database_cross_reference: VANDF:4024416

Flurothyl
type: Class
subclass of: Ethyl Ethers
MCID: MC00005218
PMOID: PMO:00016603
Subclass_of: Ethyl Ethers
Synonym: Ethane, 1,1'-oxybis(2,2,2-trifluoro)-
Synonym: FLUROTHYL
Synonym: Fluorothyl
Synonym: Flurothyl (substance)
Synonym: Flurothyl [Chemical/Ingredient]
Synonym: Flurothyl [dup] (substance)
Synonym: Flurotyl
Synonym: Hexafluorodiethyl ether
Tree Number: T6.2.14.4.2
database_cross_reference: DRUGBANK:DB08969
database_cross_reference: LCH:U001834
database_cross_reference: LCH_NW:sh85049449
database_cross_reference: MSH:D005481
database_cross_reference: NCI:C76624
database_cross_reference: NCI_FDA:9Z467FG2YK
database_cross_reference: NDFRT:N0000166638
database_cross_reference: RCD:X798F
database_cross_reference: SNM:E-7067
database_cross_reference: SNMI:C-65570
database_cross_reference: SNOMEDCT_US:255699000
database_cross_reference: SNOMEDCT_US:6261006

Methoxyflurane
type: Class
subclass of: Ethyl Ethers
subclass of: Methyl Ethers
MCID: MC00008199
PMOID: PMO:00016604
Subclass_of: Ethyl Ethers
Subclass_of: Methyl Ethers
Synonym: 2,2-Dichloro-1,1-difluoro-1-methoxyethane
Synonym: Ethane, 2,2-dichloro-1,1-difluoro-1-methoxy-
Synonym: METHOXYFLURANE
Synonym: Methoflurane
Synonym: Methofluranum
Synonym: Methoxyfluoran
Synonym: Methoxyfluran
Synonym: Methoxyflurane (substance)
Synonym: Methoxyflurane [Chemical/Ingredient]
Synonym: Methoxyfluranum
Tree Number: T6.2.14.4.3
Tree Number: T6.2.14.6.6
database_cross_reference: ATC:N02BG09
database_cross_reference: CSP:1372-8204
database_cross_reference: DRUGBANK:DB01028
database_cross_reference: LNC:LP18611-1
database_cross_reference: LNC:MTHU004796
database_cross_reference: MMSL:5081
database_cross_reference: MMSL:d00291
database_cross_reference: MSH:D008733
database_cross_reference: NCI:C75098
database_cross_reference: NCI_FDA:30905R8O7B
database_cross_reference: NDDF:001401
database_cross_reference: NDFRT:N0000007396
database_cross_reference: NDFRT:N0000147038
database_cross_reference: RXNORM:6857
database_cross_reference: SNM:E-7061
database_cross_reference: SNMI:C-6A16A
database_cross_reference: SNOMEDCT_US:11136004
database_cross_reference: VANDF:4018733

Methyl Ethers
type: Class
subclass of: Ethers
MCID: MC00008204
PMOID: PMO:00016605
Subclass_of: Ethers
Synonym: Ethers, Methyl
Synonym: Methyl Ethers [Chemical/Ingredient]
Tree Number: T6.2.14.6
database_cross_reference: MSH:D008738
database_cross_reference: NDFRT:N0000008119

Anisoles
type: Class
subclass of: Methyl Ethers
subclass of: Phenyl Ethers
MCID: MC00000948
PMOID: PMO:00016606
Subclass_of: Methyl Ethers
Subclass_of: Phenyl Ethers
Synonym: Anisoles [Chemical/Ingredient]
Synonym: Ethers, Methylphenyl
Synonym: Methylphenyl Ethers
Tree Number: T6.2.14.6.1
Tree Number: T6.2.14.7.1
database_cross_reference: MSH:D000840
database_cross_reference: NDFRT:N0000007545

Anethole Trithione
type: Class
subclass of: Thiones
MCID: MC00000908
PMOID: PMO:00016607
Subclass_of: Thiones
Synonym: (p-Methoxyphenyl)trithiopropene
Synonym: 3-(p-Anisyl)-4,5-dithiacyclopent-2-ene-1-thione
Synonym: 3-(p-Anisyl)trithione
Synonym: 3-(p-Methoxyphenyl)-4,5-dithiacyclopent-2-ene-1-thione
Synonym: 3-(p-Methoxyphenyl)trithione
Synonym: 3H-1,2-Dithiole-3-thione, 5-(4-methoxyphenyl)-
Synonym: 5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione
Synonym: 5-(p-Methoxyphenyl)-1,2-dithiacyclopent-4-ene-3-thione
Synonym: 5-(p-Methoxyphenyl)-3H-1,2-dithiole-3-thione
Synonym: ANETHOLTRITHION
Tree Number: T6.2.32.19.1
database_cross_reference: ATC:A16AX02
database_cross_reference: CHV:0000001158
database_cross_reference: DRUGBANK:DB13853
database_cross_reference: MEDCIN:199784
database_cross_reference: MSH:D000781
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C246
database_cross_reference: NCI_DCP:01005
database_cross_reference: NCI_FDA:QUY32964DJ
database_cross_reference: NCI_NCI-GLOSS:CDR0000045559
database_cross_reference: NDDF:003828
database_cross_reference: NDDF:003829
database_cross_reference: NDFRT:N0000166632
database_cross_reference: PDQ:CDR0000042828
database_cross_reference: RXNORM:820
database_cross_reference: SNOMEDCT_US:703112006

Bis(Chloromethyl) Ether
type: Class
subclass of: Methyl Ethers
MCID: MC00001771
PMOID: PMO:00016609
Subclass_of: Methyl Ethers
Synonym: 1,1'-Dichlorodimethyl Ether
Synonym: BIS(CHLOROMETHYL)ETHER
Synonym: BISCHLOROMETHYL ETHER
Synonym: Bis(Chloromethyl) Ether [Chemical/Ingredient]
Synonym: Bis(Chloromethyl)Ether
Synonym: Bis(chloromethyl) Ether
Synonym: Bis(chloromethyl)ether
Synonym: Bis-CME
Synonym: Chloromethyl Ether
Synonym: Dichlorodimethyl Ether
Tree Number: T6.2.14.6.2
database_cross_reference: LCH:U005231
database_cross_reference: LCH_NW:sh85037668
database_cross_reference: LNC:MTHU017565
database_cross_reference: MSH:D001725
database_cross_reference: NCI:C44343
database_cross_reference: NCI_FDA:77382IHE37
database_cross_reference: NDFRT:N0000166634
database_cross_reference: SNM:E-6952
database_cross_reference: SNMI:C-29062
database_cross_reference: SNOMEDCT_US:3854006

Enflurane
type: Class
subclass of: Methyl Ethers
MCID: MC00004526
PMOID: PMO:00016610
Subclass_of: Methyl Ethers
Synonym: 2-Chloro-1,1,2-trifluoroethyl difluoromethyl Ether
Synonym: 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
Synonym: 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether
Synonym: ENFLURANE
Synonym: Endurane
Synonym: Enfluran
Synonym: Enflurane (product)
Synonym: Enflurane (substance)
Synonym: Enflurane [Chemical/Ingredient]
Synonym: Enflurano
Tree Number: T6.2.14.6.3
database_cross_reference: ATC:N01AB04
database_cross_reference: CHV:0000004485
database_cross_reference: CSP:1372-8093
database_cross_reference: DRUGBANK:DB00228
database_cross_reference: LCH_NW:sh90004981
database_cross_reference: LNC:LP18610-3
database_cross_reference: LNC:MTHU004794
database_cross_reference: MMSL:3821
database_cross_reference: MMSL:7410
database_cross_reference: MMSL:d00937
database_cross_reference: MSH:D004737
database_cross_reference: NCI:C47511
database_cross_reference: NCI_FDA:91I69L5AY5
database_cross_reference: NDDF:001390
database_cross_reference: NDFRT:N0000007081
database_cross_reference: NDFRT:N0000147363
database_cross_reference: RCD:o22..
database_cross_reference: RXNORM:3920
database_cross_reference: SNM:E-7073
database_cross_reference: SNMI:C-6A114
database_cross_reference: SNOMEDCT_US:32313007
database_cross_reference: SNOMEDCT_US:387176008
database_cross_reference: VANDF:4019106

Guaiacol
type: Class
subclass of: Methyl Ethers
subclass of: Phenyl Ethers
MCID: MC00005861
PMOID: PMO:00016611
Subclass_of: Methyl Ethers
Subclass_of: Phenyl Ethers
Synonym: 1-hydroxy-2-methoxybenzene
Synonym: 2-Hydroxy-Anisole
Synonym: 2-Hydroxyanisole
Synonym: 2-Methoxy-Phenol
Synonym: 2-Methoxyphenol
Synonym: 2-methoxyl-4-vinylphenol
Synonym: 2-methoxyphenol
Synonym: Catechol, Methyl
Synonym: Creo-rectal Adulte
Synonym: Creo-rectal Enfants/children
Tree Number: T6.2.14.6.4
Tree Number: T6.2.14.7.2
database_cross_reference: DRUGBANK:DB11359
database_cross_reference: LCH_NW:sh99013827
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D006139
database_cross_reference: MTHSPL:6JKA7MAH9C
database_cross_reference: NCI:C76663
database_cross_reference: NCI_FDA:6JKA7MAH9C
database_cross_reference: NDDF:003178
database_cross_reference: NDDF:005633
database_cross_reference: NDFRT:N0000006916
database_cross_reference: NDFRT:N0000148129
database_cross_reference: RXNORM:5031
database_cross_reference: SNM:E-6858
database_cross_reference: SNMI:C-31533
database_cross_reference: SNOMEDCT_US:424656002
database_cross_reference: SNOMEDCT_US:67636005
database_cross_reference: VANDF:4020199

Isoflurane
type: Class
subclass of: Methyl Ethers
MCID: MC00007083
PMOID: PMO:00016613
Subclass_of: Methyl Ethers
Synonym: 1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether
Synonym: 1-chloro-2,2,2-Trifluoroethyl difluoromethyl ether
Synonym: 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
Synonym: Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-
Synonym: Forane Liq Inh
Synonym: ISOFLURANE
Synonym: Isocane
Synonym: Isoflurane (product)
Synonym: Isoflurane (substance)
Synonym: Isoflurane USP
Tree Number: T6.2.14.6.5
database_cross_reference: ATC:N01AB06
database_cross_reference: CHV:0000006951
database_cross_reference: CSP:1372-8195
database_cross_reference: DRUGBANK:DB00753
database_cross_reference: LCH:U002520
database_cross_reference: LCH_NW:sh86005547
database_cross_reference: LNC:LP17885-2
database_cross_reference: LNC:MTHU024731
database_cross_reference: MMSL:4326
database_cross_reference: MMSL:4926
database_cross_reference: MMSL:d00267
database_cross_reference: MSH:D007530
database_cross_reference: MTHSPL:CYS9AKD70P
database_cross_reference: NCI:C65978
database_cross_reference: NCI_FDA:CYS9AKD70P
database_cross_reference: NDDF:001391
database_cross_reference: NDFRT:N0000006307
database_cross_reference: NDFRT:N0000147364
database_cross_reference: RCD:o25..
database_cross_reference: RXNORM:6026
database_cross_reference: SNM:E-7072
database_cross_reference: SNMI:C-6A116
database_cross_reference: SNOMEDCT_US:387368002
database_cross_reference: SNOMEDCT_US:66492008
database_cross_reference: VANDF:4019107

Phenyl Ethers
type: Class
subclass of: Ethers
MCID: MC00010035
PMOID: PMO:00016614
Subclass_of: Ethers
Synonym: Ethers, Phenyl
Synonym: Phenyl Ethers [Chemical/Ingredient]
Tree Number: T6.2.14.7
database_cross_reference: MSH:D010647
database_cross_reference: NDFRT:N0000007549

Triclosan
type: Class
subclass of: Phenyl Ethers
MCID: MC00013070
PMOID: PMO:00016615
Subclass_of: Phenyl Ethers
Synonym: 1% Triclosan Anti-microbial Foaming Skin Cleanser
Synonym: 1% Triclosan Anti-microbial Skin Cleanser
Synonym: 1014 Foaming Antimicrobial
Synonym: 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether
Synonym: 2,4,4'-Trichloro-2'-hydroxydiphenyl ether
Synonym: 2-Hydroxy-2',4,4'-trichlorodiphenyl Ether
Synonym: 3 in 1 Antibacterial Hair and Body Wash
Synonym: 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol
Synonym: AEROSCENT Milk and Honey Antibacterial Moisturizing
Synonym: APRIL Bath and Shower Anti-bacterial Hand 3 Pack
Tree Number: T6.2.14.7.5
database_cross_reference: ATC:D08AE04
database_cross_reference: ATC:D09AA06
database_cross_reference: CHV:0000012549
database_cross_reference: DRUGBANK:DB08604
database_cross_reference: MEDCIN:40741
database_cross_reference: MMSL:5622
database_cross_reference: MSH:D014260
database_cross_reference: MTHSPL:4NM5039Y5X
database_cross_reference: NCI:C61986
database_cross_reference: NCI_DCP:20601
database_cross_reference: NCI_FDA:4NM5039Y5X
database_cross_reference: NDDF:003179
database_cross_reference: NDFRT:N0000006097
database_cross_reference: NDFRT:N0000148259
database_cross_reference: RCD:XM0la
database_cross_reference: RCD:mih..
database_cross_reference: RXNORM:10795
database_cross_reference: SNOMEDCT_US:125577003
database_cross_reference: SNOMEDCT_US:255908001
database_cross_reference: SNOMEDCT_US:273957004
database_cross_reference: SNOMEDCT_US:387054001
database_cross_reference: VANDF:4020553

Halogenated Diphenyl Ethers
type: Class
subclass of: Phenyl Ethers
MCID: MC00715550
PMOID: PMO:00016616
Subclass_of: Phenyl Ethers
Synonym: Diphenyl Ethers, Halogenated
Synonym: Ethers, Halogenated Diphenyl
Synonym: Halogenated Diphenyl Ethers [Chemical/Ingredient]
Tree Number: T6.2.14.7.6
database_cross_reference: MSH:D055768
database_cross_reference: NDFRT:N0000178873

Spin Labels
type: Class
subclass of: Free Radicals
MCID: MC00012122
PMOID: PMO:00016617
Subclass_of: Free Radicals
Synonym: Labels, Spin
Synonym: Spin Labels [Chemical/Ingredient]
Synonym: Spin labels
Synonym: labeling spin
Synonym: spin label
Synonym: spin labels
Tree Number: T6.2.15.2
database_cross_reference: CHV:0000011608
database_cross_reference: LCH:U004428
database_cross_reference: LCH_NW:sh85126654
database_cross_reference: MSH:D013113
database_cross_reference: NDFRT:N0000166624

Triacetoneamine-N-Oxyl
type: Class
subclass of: Spin Labels
subclass of: Cyclic N-Oxides
MCID: MC00013039
PMOID: PMO:00016618
Subclass_of: Cyclic N-Oxides
Subclass_of: Spin Labels
Synonym: 1-Piperidinyloxy, 2,2,6,6-tetramethyl-4-oxo-
Synonym: 2,2,6,6-Tetramethyl-4-oxopiperidine-1-oxyl
Synonym: TAN
Synonym: TRIACETONEAMINEOXYL N
Synonym: Triacetoneamine N Oxyl
Synonym: Triacetoneamine-N-Oxyl [Chemical/Ingredient]
Tree Number: T6.2.15.2.1
Tree Number: T6.3.6.1.1
database_cross_reference: MSH:D014216
database_cross_reference: MTH:U002322
database_cross_reference: NDFRT:N0000167210
database_cross_reference: RXNORM:10757

Hydrazines
type: Class
subclass of: Organic Chemicals
MCID: MC00006441
PMOID: PMO:00016619
Subclass_of: Organic Chemicals
Synonym: Hydrazine
Synonym: Hydrazine (substance)
Synonym: Hydrazine compound
Synonym: Hydrazine compound, NOS
Synonym: Hydrazine, NOS
Synonym: Hydrazines [Chemical/Ingredient]
Synonym: hydrazine
Synonym: hydrazine compound
Synonym: hydrazines
Tree Number: T6.2.16
database_cross_reference: AOD:0000020209
database_cross_reference: CHV:0000006336
database_cross_reference: CSP:0316-3852
database_cross_reference: LCH:U002268
database_cross_reference: LCH_NW:sh85063356
database_cross_reference: MSH:D006834
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:014054
database_cross_reference: NDFRT:N0000007972
database_cross_reference: SNM:E-5761
database_cross_reference: SNMI:C-21900
database_cross_reference: SNOMEDCT_US:34641002

Benserazide
type: Class
subclass of: Hydrazines
MCID: MC00001556
PMOID: PMO:00016620
Subclass_of: Hydrazines
Synonym: BENSERAZIDE
Synonym: Benserazide (product)
Synonym: Benserazide (substance)
Synonym: Benserazide - chemical
Synonym: Benserazide - chemical (substance)
Synonym: Benserazide [Chemical/Ingredient]
Synonym: Benzylhydrazine, Seryltrihydroxy
Synonym: DL-Serine 2-((2,3,4-trihydroxyphenyl)methyl)hydrazide
Synonym: DL-Serine, 2-((2,3,4-trihydroxyphenyl)methyl)hydrazide
Synonym: DL-Seryltrihydroxybenzylhydrazine
Tree Number: T6.2.16.1
database_cross_reference: CHV:0000001779
database_cross_reference: DRUGBANK:DB12783
database_cross_reference: MSH:D001545
database_cross_reference: NCI:C81109
database_cross_reference: NCI_FDA:762OS3ZEJU
database_cross_reference: NDDF:003682
database_cross_reference: NDFRT:N0000166563
database_cross_reference: RXNORM:1374
database_cross_reference: SNOMEDCT_US:391821005
database_cross_reference: SNOMEDCT_US:420240007

Hydrazones
type: Class
subclass of: Hydrazines
MCID: MC00006442
PMOID: PMO:00016621
Subclass_of: Hydrazines
Synonym: Hydrazones [Chemical/Ingredient]
Synonym: hydrazone
Tree Number: T6.2.16.3
database_cross_reference: CSP:0316-4633
database_cross_reference: LCH_NW:sh92001500
database_cross_reference: MSH:D006835
database_cross_reference: NDFRT:N0000166562

Carbonyl Cyanide m-Chlorophenyl Hydrazone
type: Class
subclass of: Hydrazones
subclass of: Nitriles
MCID: MC00002250
PMOID: PMO:00016622
Subclass_of: Hydrazones
Subclass_of: Nitriles
Synonym: CARBONYL CYANIDE CHLOROPHENYL HYDRAZONE M
Synonym: CARBONYL CYANIDE CHLOROPHENYL HYDRAZONE META
Synonym: CCCP
Synonym: Carbonyl Cyanide m Chlorophenyl Hydrazone
Synonym: Carbonyl Cyanide m-Chlorophenyl Hydrazone [Chemical/Ingredient]
Synonym: Carbonyl Cyanide meta Chlorophenyl Hydrazone
Synonym: Carbonyl Cyanide meta-Chlorophenyl Hydrazone
Synonym: Propanedinitrile, ((3-chlorophenyl)hydrazono)-
Tree Number: T6.2.16.3.1
Tree Number: T6.2.23.6
database_cross_reference: MSH:D002258
database_cross_reference: NDFRT:N0000166566

Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
type: Class
subclass of: Hydrazones
subclass of: Nitriles
MCID: MC00002251
PMOID: PMO:00016623
Subclass_of: Hydrazones
Subclass_of: Nitriles
Synonym: CARBONYL CYANIDE TRIFLUOROMETHOXYPHENYLHYDRAZONE P
Synonym: CARBONYL CYANIDE TRIFLUOROMETHOXYPHENYLHYDRAZONE PARA
Synonym: Carbonyl Cyanide p Trifluoromethoxyphenylhydrazone
Synonym: Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone [Chemical/Ingredient]
Synonym: Carbonyl Cyanide para Trifluoromethoxyphenylhydrazone
Synonym: Carbonyl Cyanide para-Trifluoromethoxyphenylhydrazone
Synonym: Cyanide p-Trifluoromethoxyphenylhydrazone, Carbonyl
Synonym: Cyanide para-Trifluoromethoxyphenylhydrazone, Carbonyl
Synonym: FCCP
Tree Number: T6.2.16.3.2
Tree Number: T6.2.23.7
database_cross_reference: CHV:0000002403
database_cross_reference: MSH:D002259
database_cross_reference: NDFRT:N0000166565

Iproniazid
type: Class
subclass of: Hydrazines
subclass of: Isonicotinic Acids
MCID: MC00007039
PMOID: PMO:00016624
Subclass_of: Hydrazines
Subclass_of: Isonicotinic Acids
Synonym: 1-Isonicotinoyl-2-isopropylhydrazine
Synonym: 4-Pyridinecarboxylic acid, 2-(1-methylethyl)hydrazide
Synonym: IPRONIAZID
Synonym: Iprazid
Synonym: Iproniazid (product)
Synonym: Iproniazid (substance)
Synonym: Iproniazid [Chemical/Ingredient]
Synonym: Ipronid
Synonym: Ipronin
Synonym: iproniazid
Tree Number: T6.2.16.4
Tree Number: T6.3.2.3.2
database_cross_reference: CSP:0316-3852
database_cross_reference: DRUGBANK:DB04818
database_cross_reference: MSH:D007490
database_cross_reference: NCI:C97714
database_cross_reference: NCI_FDA:D892HFI3XA
database_cross_reference: NDDF:005260
database_cross_reference: NDFRT:N0000167316
database_cross_reference: PSY:26600
database_cross_reference: RCD:d82..
database_cross_reference: RXNORM:5981
database_cross_reference: SNM:E-7910
database_cross_reference: SNMI:C-62440
database_cross_reference: SNOMEDCT_US:387438007
database_cross_reference: SNOMEDCT_US:76962009

Isoniazid
type: Class
subclass of: Hydrazines
subclass of: Isonicotinic Acids
MCID: MC00007095
PMOID: PMO:00016625
Subclass_of: Hydrazines
Subclass_of: Isonicotinic Acids
Synonym: 4-Pyridinecarboxylic acid, hydrazide
Synonym: Dom-isoniazid 300mg Tablets
Synonym: Hydrazide, Isonicotinic Acid
Synonym: INA - Isoniazid
Synonym: INAH - Isoniazid
Synonym: INH
Synonym: ISONIAZID
Synonym: Isoniazid (product)
Synonym: Isoniazid (substance)
Synonym: Isoniazid [Chemical/Ingredient]
Tree Number: T6.2.16.5
Tree Number: T6.3.2.3.3
database_cross_reference: AOD:0000019768
database_cross_reference: AOD:0000028772
database_cross_reference: ATC:J04AC01
database_cross_reference: CHV:0000006959
database_cross_reference: CSP:0316-4065
database_cross_reference: DRUGBANK:DB00951
database_cross_reference: LCH:U002523
database_cross_reference: LCH_NW:sh87001831
database_cross_reference: LNC:LP15831-8
database_cross_reference: LNC:MTHU008094
database_cross_reference: MEDCIN:40361
database_cross_reference: MMSL:2955
database_cross_reference: MMSL:4929
database_cross_reference: MMSL:d00101
database_cross_reference: MSH:D007538
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:V83O1VOZ8L
database_cross_reference: NCI:C600
database_cross_reference: NCI_DTP:NSC0009659
database_cross_reference: NCI_FDA:V83O1VOZ8L
database_cross_reference: NDDF:002844
database_cross_reference: NDFRT:N0000006318
database_cross_reference: NDFRT:N0000145890
database_cross_reference: PDQ:CDR0000039484
database_cross_reference: PSY:26730
database_cross_reference: RCD:ed4..
database_cross_reference: RXNORM:6038
database_cross_reference: SNM:E-7344
database_cross_reference: SNMI:C-55260
database_cross_reference: SNOMEDCT_US:387472004
database_cross_reference: SNOMEDCT_US:81335000
database_cross_reference: USPMG:MTHU000453
database_cross_reference: VANDF:4017505

Methylhydrazines
type: Class
subclass of: Hydrazines
MCID: MC00008233
PMOID: PMO:00016626
Subclass_of: Hydrazines
Synonym: Methylhydrazines [Chemical/Ingredient]
Tree Number: T6.2.16.6
database_cross_reference: MSH:D008763
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166558

Dimethylhydrazines
type: Class
subclass of: Methylhydrazines
MCID: MC00003967
PMOID: PMO:00016627
Subclass_of: Methylhydrazines
Synonym: Dimethylhydrazines [Chemical/Ingredient]
Tree Number: T6.2.16.6.1
database_cross_reference: MSH:D004127
database_cross_reference: NCI:C438
database_cross_reference: NDFRT:N0000166559

Monomethylhydrazine
type: Class
subclass of: Methylhydrazines
MCID: MC00008398
PMOID: PMO:00016629
Subclass_of: Methylhydrazines
Synonym: Hydrazine, methyl-
Synonym: Methyl hydrazine
Synonym: Methylhydrazine
Synonym: Monomethyl hydrazine
Synonym: Monomethyl hydrazine (substance)
Synonym: Monomethylhydrazine [Chemical/Ingredient]
Synonym: methylhydrazine
Tree Number: T6.2.16.6.2
database_cross_reference: CSP:0316-4207
database_cross_reference: LNC:LP34816-6
database_cross_reference: LNC:MTHU017303
database_cross_reference: MSH:D009002
database_cross_reference: NDFRT:N0000166561
database_cross_reference: SNMI:C-21923
database_cross_reference: SNOMEDCT_US:71823000

Phenelzine
type: Class
subclass of: Hydrazines
MCID: MC00010006
PMOID: PMO:00016630
Subclass_of: Hydrazines
Synonym: 2 Phenethylhydrazine
Synonym: 2-Phenethylhydrazine
Synonym: Fenelzin
Synonym: Fenelzina
Synonym: Hydrazine, (2-phenylethyl)-
Synonym: MAOI - Phenelzine
Synonym: PHENELZINE
Synonym: Phenelzin
Synonym: Phenelzine (product)
Synonym: Phenelzine (substance)
Tree Number: T6.2.16.7
database_cross_reference: AOD:0000019370
database_cross_reference: ATC:N06AF03
database_cross_reference: CHV:0000009593
database_cross_reference: CSP:0316-4349
database_cross_reference: DRUGBANK:DB00780
database_cross_reference: LNC:LP17998-3
database_cross_reference: LNC:MTHU024864
database_cross_reference: MEDCIN:340468
database_cross_reference: MMSL:d00883
database_cross_reference: MSH:D010624
database_cross_reference: MTHSPL:O408N561GF
database_cross_reference: NCI:C61888
database_cross_reference: NCI_FDA:O408N561GF
database_cross_reference: NDDF:004596
database_cross_reference: NDFRT:N0000005861
database_cross_reference: NDFRT:N0000147971
database_cross_reference: PSY:38130
database_cross_reference: RCD:d81..
database_cross_reference: RXNORM:8123
database_cross_reference: SNM:E-7935
database_cross_reference: SNMI:C-62420
database_cross_reference: SNOMEDCT_US:387528000
database_cross_reference: SNOMEDCT_US:9500005
database_cross_reference: USPMG:MTHU000296
database_cross_reference: VANDF:4019886

Phenylhydrazines
type: Class
subclass of: Hydrazines
MCID: MC00010049
PMOID: PMO:00016631
Subclass_of: Hydrazines
Synonym: Phenylhydrazines [Chemical/Ingredient]
Tree Number: T6.2.16.8
database_cross_reference: MSH:D010659
database_cross_reference: NDFRT:N0000166556

Todralazine
type: Class
subclass of: Hydrazines
MCID: MC00012892
PMOID: PMO:00016632
Subclass_of: Hydrazines
Synonym: Ecarazine
Synonym: Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, monohydrochloride
Synonym: TODRALAZINE
Synonym: Todralazine [Chemical/Ingredient]
Synonym: Todrazoline
Tree Number: T6.2.16.9
database_cross_reference: MSH:D014032
database_cross_reference: NCI:C77080
database_cross_reference: NCI_FDA:WEN3K83YKD
database_cross_reference: NDFRT:N0000167109

Hydrocarbons
type: Class
subclass of: Organic Chemicals
MCID: MC00006445
PMOID: PMO:00016633
Subclass_of: Organic Chemicals
Synonym: 205-207 HYDROCARBONS
Synonym: HYDROCARBONS
Synonym: Hydrocarbon
Synonym: Hydrocarbon (substance)
Synonym: Hydrocarbon, NOS
Synonym: Hydrocarbons [Chemical/Ingredient]
Synonym: hydrocarbon
Synonym: hydrocarbons
Tree Number: T6.2.17
database_cross_reference: AOD:0000019650
database_cross_reference: CHV:0000006339
database_cross_reference: CSP:1472-3653
database_cross_reference: LCH:U002270
database_cross_reference: LCH_NW:sh85063372
database_cross_reference: LNC:LP31750-0
database_cross_reference: MSH:D006838
database_cross_reference: NCI:C552
database_cross_reference: NCI_NCI-GLOSS:CDR0000661192
database_cross_reference: NDFRT:N0000007973
database_cross_reference: RCD:Xa7Mu
database_cross_reference: SNM:E-5410
database_cross_reference: SNM:U000132
database_cross_reference: SNMI:C-20500
database_cross_reference: SNOMEDCT_US:80382003

Hydrocarbons, Acyclic
type: Class
subclass of: Hydrocarbons
MCID: MC00006446
PMOID: PMO:00016634
Subclass_of: Hydrocarbons
Synonym: Acyclic Hydrocarbons
Synonym: Hydrocarbons, Acyclic [Chemical/Ingredient]
Synonym: acyclic hydrocarbons
Tree Number: T6.2.17.1
database_cross_reference: AOD:0000019652
database_cross_reference: MSH:D006839
database_cross_reference: NDFRT:N0000008227

Alkanes
type: Class
subclass of: Hydrocarbons, Acyclic
MCID: MC00000563
PMOID: PMO:00016635
Subclass_of: Hydrocarbons, Acyclic
Synonym: Alkane
Synonym: Alkane (substance)
Synonym: Alkanes [Chemical/Ingredient]
Synonym: alkane
Synonym: alkanes
Tree Number: T6.2.17.1.1
database_cross_reference: AOD:0000019664
database_cross_reference: CHV:0000000902
database_cross_reference: CSP:0094-0101
database_cross_reference: LCH_NW:sh85097763
database_cross_reference: MSH:D000473
database_cross_reference: NDFRT:N0000007505
database_cross_reference: RCD:Xa7NW
database_cross_reference: SNOMEDCT_US:299982002

Tetranitromethane
type: Class
subclass of: Nitroparaffins
MCID: MC00012670
PMOID: PMO:00016644
Subclass_of: Nitroparaffins
Synonym: Methane, tetranitro-
Synonym: TETRANITROMETHANE
Synonym: TNM
Synonym: Tetan
Synonym: Tetranitromethane (substance)
Synonym: Tetranitromethane [Chemical/Ingredient]
Tree Number: T6.2.25.6.1
database_cross_reference: LNC:LP57604-8
database_cross_reference: MSH:D013774
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44453
database_cross_reference: NCI_FDA:K1G7CKU98F
database_cross_reference: NDFRT:N0000166578
database_cross_reference: SNM:E-5733
database_cross_reference: SNMI:C-21903
database_cross_reference: SNOMEDCT_US:35684008

Nitroparaffins
type: Class
subclass of: Nitro Compounds
MCID: MC00008949
PMOID: PMO:00016645
Subclass_of: Nitro Compounds
Synonym: Nitroparaffins [Chemical/Ingredient]
Tree Number: T6.2.25.6
database_cross_reference: LCH:U003250
database_cross_reference: MSH:D009595
database_cross_reference: NDFRT:N0000166577

Mesna
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00000044
PMOID: PMO:00016654
Subclass_of: Sulfhydryl Compounds
Synonym: 2-Mercaptoethane
Synonym: 2-Mercaptoethanesulfonate, Sodium Salt
Synonym: 2-Mercaptoethanesulfonic Acid Sodium Salt
Synonym: 2-Mercaptoethanesulphonate, Sodium
Synonym: 2-mercaptoethane sulfonate Na
Synonym: 2-mercaptoethylsulfonate
Synonym: 2-sulfanylethylsulfonate
Synonym: CoM
Synonym: Ethanesulfonic acid, 2-mercapto-, monosodium salt
Synonym: HS-CoM
Tree Number: T6.2.32.6.12
database_cross_reference: ATC:R05CB05
database_cross_reference: ATC:V03AF01
database_cross_reference: CHV:0000000508
database_cross_reference: CSP:4005-0035
database_cross_reference: DRUGBANK:DB09110
database_cross_reference: MEDCIN:48713
database_cross_reference: MMSL:41498
database_cross_reference: MMSL:5057
database_cross_reference: MMSL:d01411
database_cross_reference: MSH:D015080
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NR7O1405Q9
database_cross_reference: NCI:C192
database_cross_reference: NCI_DCP:01550
database_cross_reference: NCI_DTP:NSC0113891
database_cross_reference: NCI_FDA:NR7O1405Q9
database_cross_reference: NCI_NCI-GLOSS:CDR0000045257
database_cross_reference: NDDF:002678
database_cross_reference: NDFRT:N0000007017
database_cross_reference: NDFRT:N0000147597
database_cross_reference: PDQ:CDR0000039759
database_cross_reference: RCD:h61..
database_cross_reference: RXNORM:44
database_cross_reference: SNOMEDCT_US:108821000
database_cross_reference: SNOMEDCT_US:386922000
database_cross_reference: VANDF:4019477

HEPES
type: Class
subclass of: Piperazines
MCID: MC00006148
PMOID: PMO:00016655
Subclass_of: Piperazines
Synonym: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-
Synonym: HEPES [Chemical/Ingredient]
Synonym: HYDROXYETHYLPIPERAZINE ETHANESULFONIC ACID N N 02 02
Synonym: N 2 Hydroxyethylpiperazine N' 2' ethanesulfonic Acid
Synonym: N-2-Hydroxyethylpiperazine-N'-2'-ethanesulfonic Acid
Synonym: hepe
Synonym: hepes
Tree Number: T6.3.5.15.16
database_cross_reference: CHV:0000006065
database_cross_reference: MSH:D006531
database_cross_reference: NDDF:015070
database_cross_reference: NDFRT:N0000167122

Fumonisins
type: Class
subclass of: PMO:00024389
MCID: MC00107532
PMOID: PMO:00016662
Subclass_of: Mycotoxins
Synonym: Fumonisin
Synonym: Fumonisin (substance)
Synonym: Fumonisins [Chemical/Ingredient]
Synonym: fumonisin
Synonym: fumonisins
Tree Number: T6.13.8.6.17
database_cross_reference: CHV:0000028073
database_cross_reference: LCH_NW:sh95009543
database_cross_reference: LNC:LP14120-7
database_cross_reference: LNC:MTHU009344
database_cross_reference: MSH:D037341
database_cross_reference: NDFRT:N0000171407
database_cross_reference: SNMI:C-30842
database_cross_reference: SNOMEDCT_US:55261004

Alkenes
type: Class
subclass of: Hydrocarbons, Acyclic
MCID: MC00000565
PMOID: PMO:00016663
Subclass_of: Hydrocarbons, Acyclic
Synonym: Alkene
Synonym: Alkene (substance)
Synonym: Alkenes [Chemical/Ingredient]
Synonym: Olefin
Synonym: Olefin (substance)
Synonym: Olefins
Synonym: alkene
Synonym: alkenes
Synonym: olefin
Tree Number: T6.2.17.1.2
database_cross_reference: AOD:0000019673
database_cross_reference: CHV:0000000904
database_cross_reference: CSP:0094-2588
database_cross_reference: LCH_NW:sh85094589
database_cross_reference: MSH:D000475
database_cross_reference: NDFRT:N0000008134
database_cross_reference: RCD:Xa7NX
database_cross_reference: SNMI:C-2A410
database_cross_reference: SNOMEDCT_US:116565002
database_cross_reference: SNOMEDCT_US:9749001

Allylglycine
type: Class
subclass of: PMO:00021314
MCID: MC00000595
PMOID: PMO:00016665
Subclass_of: Glycine
Synonym: 2-Amino-4-Pentenoic Acid
Synonym: 4-Pentenoic acid, 2-amino-
Synonym: Allylglycine [Chemical/Ingredient]
Tree Number: T6.10.1.14.1
database_cross_reference: MSH:D000501
database_cross_reference: NDFRT:N0000170215

Carotenoids
type: Class
subclass of: Terpenes
subclass of: PMO:00024379
MCID: MC00002337
PMOID: PMO:00016673
Subclass_of: Pigments, Biological
Subclass_of: Terpenes
Synonym: Carotenes and Carotenoids
Synonym: Carotenoid
Synonym: Carotenoids (NOS)
Synonym: Carotenoids [Chemical/Ingredient]
Synonym: Carotinoid
Synonym: Carotinoid (substance)
Synonym: Carotinoids
Synonym: carotenoid
Synonym: carotenoids
Tree Number: T6.13.7.4
Tree Number: T6.2.17.6.2
database_cross_reference: AOD:0000020997
database_cross_reference: CHV:0000002473
database_cross_reference: CSP:2876-1992
database_cross_reference: LCH:U000817
database_cross_reference: LCH_NW:sh85020408
database_cross_reference: MSH:D002338
database_cross_reference: NCI:C351
database_cross_reference: NCI_CRCH:C351
database_cross_reference: NCI_DCP:30953
database_cross_reference: NCI_NCI-GLOSS:CDR0000046132
database_cross_reference: NDDF:012701
database_cross_reference: NDFRT:N0000008165
database_cross_reference: SNOMEDCT_US:413767000

Retinoids
type: Class
subclass of: Carotenoids
MCID: MC00011325
PMOID: PMO:00016674
Subclass_of: Carotenoids
Synonym: RA - Retinoic acid product
Synonym: Retinoic Acid Agent
Synonym: Retinoic Acid and Derivatives
Synonym: Retinoic Acids
Synonym: Retinoid
Synonym: Retinoid (product)
Synonym: Retinoid (substance)
Synonym: Retinoid product
Synonym: Retinoids [Chemical/Ingredient]
Synonym: retinoid
Tree Number: T6.13.7.4.1
database_cross_reference: AOD:0000020990
database_cross_reference: CHV:0000010814
database_cross_reference: CSP:3147-3660
database_cross_reference: LCH:U004111
database_cross_reference: LCH_NW:sh85113339
database_cross_reference: MEDCIN:72088
database_cross_reference: MSH:D012176
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C68299
database_cross_reference: NCI:C804
database_cross_reference: NCI_CRCH:C68299
database_cross_reference: NCI_NCI-GLOSS:CDR0000045870
database_cross_reference: NDFRT:N0000007700
database_cross_reference: RCD:x01Fq
database_cross_reference: SNOMEDCT_US:116085009
database_cross_reference: SNOMEDCT_US:372579009
database_cross_reference: USPMG:MTHU002537

beta Carotene
type: Class
subclass of: Carotenoids
MCID: MC00021316
PMOID: PMO:00016681
Subclass_of: Carotenoids
Synonym: .BETA.-CAROTENE
Synonym: .BETA.-Carotene
Synonym: .Beta.-Carotene
Synonym: .Beta.-carotene
Synonym: .beta.-Carotene
Synonym: .beta.-carotene
Synonym: 3,7,12,16-tetramethyl-1,18-bis(2,6,6-trimethyl-1-cyclohexenyl)-octadeca-1,3,5,7,9,11,13,15,17-nonaene
Synonym: A.B.C. Formula #1
Synonym: Absorbene
Synonym: Acti-carotene + Zn Caplet
Tree Number: T6.13.7.4.2
database_cross_reference: AOD:0000020998
database_cross_reference: ATC:A11CA02
database_cross_reference: ATC:D02BB01
database_cross_reference: CHV:0000013582
database_cross_reference: DRUGBANK:DB00162
database_cross_reference: DRUGBANK:DB06755
database_cross_reference: LCH_NW:sh2008007530
database_cross_reference: MEDCIN:195894
database_cross_reference: MMSL:4269
database_cross_reference: MMSL:5679
database_cross_reference: MMSL:6766
database_cross_reference: MMSL:d01385
database_cross_reference: MSH:D019207
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:01YAE03M7J
database_cross_reference: NCI:C1016
database_cross_reference: NCI_CRCH:C1016
database_cross_reference: NCI_DCP:252
database_cross_reference: NCI_DTP:NSC0062794
database_cross_reference: NCI_FDA:01YAE03M7J
database_cross_reference: NCI_NCI-GLOSS:CDR0000045328
database_cross_reference: NDDF:001003
database_cross_reference: NDDF:002022
database_cross_reference: NDFRT:N0000007226
database_cross_reference: NDFRT:N0000146154
database_cross_reference: NDFRT:N0000148286
database_cross_reference: PDQ:CDR0000040992
database_cross_reference: RCD:X80R8
database_cross_reference: RCD:iz11.
database_cross_reference: RXNORM:19143
database_cross_reference: SNM:E-8764
database_cross_reference: SNMI:C-A4210
database_cross_reference: SNMI:F-BB062
database_cross_reference: SNOMEDCT_US:103068006
database_cross_reference: SNOMEDCT_US:127385007
database_cross_reference: SNOMEDCT_US:329507006
database_cross_reference: SNOMEDCT_US:36142007
database_cross_reference: VANDF:4017793
database_cross_reference: VANDF:4020599

zeta Carotene
type: Class
subclass of: Carotenoids
MCID: MC00013802
PMOID: PMO:00016682
Subclass_of: Carotenoids
Synonym: Carotene, zeta
Synonym: zeta Carotene [Chemical/Ingredient]
Synonym: zeta-Carotene
Tree Number: T6.13.7.4.3
database_cross_reference: MSH:D024321
database_cross_reference: NDFRT:N0000171224

Xanthophylls
type: Class
subclass of: Carotenoids
MCID: MC00337734
PMOID: PMO:00016683
Subclass_of: Carotenoids
Synonym: Carotenoids, Xanthophyll
Synonym: Doctor Super Lutein
Synonym: Macuzin
Synonym: Ocuvel
Synonym: Xanthophyll
Synonym: Xanthophyll Carotenoids
Synonym: Xanthophylls [Chemical/Ingredient]
Synonym: Xantofyl
Synonym: xanthophyll
Synonym: xanthophylls
Tree Number: T6.13.7.4.4
database_cross_reference: CHV:0000053424
database_cross_reference: DRUGBANK:DB00137
database_cross_reference: LCH:U005058
database_cross_reference: LCH_NW:sh85148772
database_cross_reference: MSH:D024341
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C1965
database_cross_reference: NDFRT:N0000171225

Mepartricin
type: Class
subclass of: Macrolides
MCID: MC00008073
PMOID: PMO:00016692
Subclass_of: Macrolides
Synonym: Mepartricin [Chemical/Ingredient]
Synonym: Methyl Partricin
Synonym: Methylpartricin
Synonym: Partricin, methyl ester
Synonym: mepartricin
Synonym: methyl partricin
Tree Number: T6.2.21.8.3
database_cross_reference: ATC:A01AB16
database_cross_reference: ATC:D01AA06
database_cross_reference: ATC:G01AA09
database_cross_reference: ATC:G04CX03
database_cross_reference: CHV:0000007968
database_cross_reference: MSH:D008613
database_cross_reference: NDFRT:N0000168423

Neoprene
type: Class
subclass of: PMO:00024438
MCID: MC00008750
PMOID: PMO:00016693
Subclass_of: Elastomers
Synonym: 1,3-Butadiene, 2-chloro-, homopolymer
Synonym: Chloroprene Polymer
Synonym: Chloroprene Polymers
Synonym: Duprene
Synonym: Neoprene (substance)
Synonym: Neoprene [Chemical/Ingredient]
Synonym: Polychloroprene
Synonym: Polychloroprenes
Synonym: chloroprene polymer
Synonym: neoprene
Tree Number: T6.14.9.14.1
database_cross_reference: CHV:0000008571
database_cross_reference: CSP:2349-0686
database_cross_reference: MSH:D009387
database_cross_reference: NCI:C44356
database_cross_reference: NDDF:012194
database_cross_reference: NDFRT:N0000171516
database_cross_reference: RCD:X90Eg
database_cross_reference: SNOMEDCT_US:261248007

Polyethylenes
type: Class
subclass of: Plastics
MCID: MC00010420
PMOID: PMO:00016694
Subclass_of: Plastics
Synonym: Ethene Homopolymers
Synonym: Ethylene Homopolymers
Synonym: Ethylene Polymers
Synonym: Homopolymers, Ethene
Synonym: Polyethylenes [Chemical/Ingredient]
Synonym: Polymers, Ethylene
Synonym: polyethylene
Tree Number: T6.14.9.6.2
Tree Number: T6.5.2.8.2
database_cross_reference: CHV:0000009918
database_cross_reference: CSP:2349-0299
database_cross_reference: MSH:D011095
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007673
database_cross_reference: RXNORM:8519

Polyethyleneimine
type: Class
subclass of: Imines
MCID: MC00010419
PMOID: PMO:00016695
Subclass_of: Imines
Synonym: Aziridine, homopolymer
Synonym: Polyaziridine
Synonym: Polyaziridines
Synonym: Polyethyleneimine [Chemical/Ingredient]
Synonym: Polyethyleneimines
Synonym: Polyethylenimine
Synonym: Polyethylenimines
Synonym: polyethyleneimine
Synonym: polyethylenimine
Tree Number: T6.2.19.3
database_cross_reference: AOD:0000020204
database_cross_reference: CHV:0000009917
database_cross_reference: MSH:D011094
database_cross_reference: NDFRT:N0000171540

Polypropylenes
type: Class
subclass of: Plastics
MCID: MC00010457
PMOID: PMO:00016697
Subclass_of: Plastics
Synonym: Polymers, Propene
Synonym: Polymers, Propylene
Synonym: Polypropylene
Synonym: Polypropylene (substance)
Synonym: Polypropylenes [Chemical/Ingredient]
Synonym: Propene Polymers
Synonym: Propylene Polymers
Synonym: polypropylene
Tree Number: T6.14.9.6.3
Tree Number: T6.5.2.8.3
database_cross_reference: CHV:0000009936
database_cross_reference: CSP:2349-0376
database_cross_reference: LCH:U003763
database_cross_reference: LCH_NW:sh85104718
database_cross_reference: MSH:D011126
database_cross_reference: NDFRT:N0000171538
database_cross_reference: RCD:X79X1
database_cross_reference: SNOMEDCT_US:256633009

Polyvinyls
type: Class
subclass of: Plastics
MCID: MC00010483
PMOID: PMO:00016698
Subclass_of: Plastics
Synonym: Polyvinyl
Synonym: Polyvinyls [Chemical/Ingredient]
Synonym: polyvinyl
Tree Number: T6.14.9.6.6
Tree Number: T6.5.2.8.6
database_cross_reference: CHV:0000009953
database_cross_reference: CSP:2349-0507
database_cross_reference: MSH:D011145
database_cross_reference: NDFRT:N0000007851

Polyvinyl Chloride
type: Class
subclass of: PMO:00024438
MCID: MC00010481
PMOID: PMO:00016701
Subclass_of: Elastomers
Synonym: Chlorethylene polymer
Synonym: Chloride, Polyvinyl
Synonym: Chloroethylene Homopolymer
Synonym: Chloroethylene Polymer
Synonym: Chloroethylene polymer
Synonym: Ethene, chloro-, homopolymer
Synonym: Homopolymer, Chloroethylene
Synonym: POLYVINYL CHLORIDE
Synonym: PVC
Synonym: PVC (polyvinylchloride)
Tree Number: T6.14.9.14.3
database_cross_reference: CHV:0000009952
database_cross_reference: CSP:2349-0507
database_cross_reference: LCH:U003768
database_cross_reference: LCH_NW:sh85104742
database_cross_reference: LNC:LA14249-9
database_cross_reference: MSH:D011143
database_cross_reference: MTH:U000124
database_cross_reference: NDDF:010320
database_cross_reference: NDFRT:N0000171548
database_cross_reference: NDFRT:N0000171755
database_cross_reference: RCD:X79U6
database_cross_reference: SNM:E-6956
database_cross_reference: SNMI:C-2A312
database_cross_reference: SNOMEDCT_US:256518006
database_cross_reference: SNOMEDCT_US:35233000
database_cross_reference: VANDF:4025219

Polyvinylpyridine N-Oxide
type: Class
subclass of: Pyridines
MCID: MC00010482
PMOID: PMO:00016702
Subclass_of: Pyridines
Synonym: N-Oxide, Poly-2-vinylpyridine
Synonym: N-Oxide, Polyvinylpyridine
Synonym: Poly 2 vinylpyridine N Oxide
Synonym: Poly-2-vinylpyridine N-Oxide
Synonym: Polyvinylpyridine N Oxide
Synonym: Polyvinylpyridine N-Oxide [Chemical/Ingredient]
Synonym: Pyridine, 2-ethenyl-, 1-oxide, homopolymer
Tree Number: T6.3.5.20.21
database_cross_reference: MSH:D011144
database_cross_reference: NDFRT:N0000167245

Alkynes
type: Class
subclass of: Hydrocarbons, Acyclic
MCID: MC00000571
PMOID: PMO:00016707
Subclass_of: Hydrocarbons, Acyclic
Synonym: Acetylenes
Synonym: Acetylenic Compounds
Synonym: Alkyne
Synonym: Alkyne (substance)
Synonym: Alkynes [Chemical/Ingredient]
Synonym: alkyne
Synonym: alkynes
Tree Number: T6.2.17.1.3
database_cross_reference: AOD:0000019678
database_cross_reference: CSP:0097-1361
database_cross_reference: LCH_NW:sh97007297
database_cross_reference: MSH:D000480
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166367
database_cross_reference: RCD:Xa7NY
database_cross_reference: SNOMEDCT_US:299984001

Hydrocarbons, Cyclic
type: Class
subclass of: Hydrocarbons
MCID: MC00006451
PMOID: PMO:00016712
Subclass_of: Hydrocarbons
Synonym: Cyclic Hydrocarbons
Synonym: Hydrocarbons, Cyclic [Chemical/Ingredient]
Synonym: cyclic hydrocarbons
Tree Number: T6.2.17.2
database_cross_reference: AOD:0000019659
database_cross_reference: MSH:D006844
database_cross_reference: NDFRT:N0000008280

Bridged-Ring Compounds
type: Class
subclass of: Hydrocarbons, Cyclic
subclass of: Polycyclic Compounds
MCID: MC00001939
PMOID: PMO:00016713
Subclass_of: Hydrocarbons, Cyclic
Subclass_of: Polycyclic Compounds
Synonym: BRIDGED CPDS
Synonym: Bridged Compounds
Synonym: Bridged Ring Compounds
Synonym: Bridged-Ring Compounds [Chemical/Ingredient]
Synonym: bridged cyclic compound
Tree Number: T6.2.17.2.1
Tree Number: T6.4.2
database_cross_reference: CSP:0779-2529
database_cross_reference: MSH:D001952
database_cross_reference: NDFRT:N0000008149

Bridged Bicyclo Compounds
type: Class
subclass of: Bridged-Ring Compounds
MCID: MC01054879
PMOID: PMO:00016718
Subclass_of: Bridged-Ring Compounds
Synonym: Bicyclo Compounds, Bridged
Synonym: Bridged Bicyclo Compounds [Chemical/Ingredient]
Tree Number: T6.4.2.1
database_cross_reference: MSH:D001643
database_cross_reference: NDFRT:N0000193167

Biperiden
type: Class
subclass of: Piperidines
MCID: MC00001765
PMOID: PMO:00016719
Subclass_of: Piperidines
Synonym: 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol
Synonym: 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-
Synonym: Akineton Tab 2mg
Synonym: BIPERIDEN
Synonym: Beperiden
Synonym: Bilino
Synonym: Biperiden (product)
Synonym: Biperiden (substance)
Synonym: Biperiden [Chemical/Ingredient]
Synonym: Biperidene
Tree Number: T6.3.5.16.3
database_cross_reference: ATC:N04AA02
database_cross_reference: CHV:0000001916
database_cross_reference: DRUGBANK:DB00810
database_cross_reference: LNC:LP18883-6
database_cross_reference: LNC:MTHU006765
database_cross_reference: MMSL:4285
database_cross_reference: MMSL:d00972
database_cross_reference: MSH:D001712
database_cross_reference: NCI:C65263
database_cross_reference: NCI_FDA:0FRP6G56LD
database_cross_reference: NDDF:001644
database_cross_reference: NDFRT:N0000007878
database_cross_reference: NDFRT:N0000147728
database_cross_reference: RCD:dr4..
database_cross_reference: RXNORM:1589
database_cross_reference: SNM:E-7554
database_cross_reference: SNMI:C-67520
database_cross_reference: SNOMEDCT_US:387359004
database_cross_reference: SNOMEDCT_US:65041000
database_cross_reference: VANDF:4019635

Hydrocarbons, Alicyclic
type: Class
subclass of: Hydrocarbons, Cyclic
MCID: MC00006447
PMOID: PMO:00016720
Subclass_of: Hydrocarbons, Cyclic
Synonym: Alicyclic Hydrocarbons
Synonym: Hydrocarbons, Alicyclic [Chemical/Ingredient]
Tree Number: T6.2.17.2.2
database_cross_reference: MSH:D006840
database_cross_reference: NDFRT:N0000008228

Cycloparaffins
type: Class
subclass of: Macrocyclic Compounds
MCID: MC00003422
PMOID: PMO:00016721
Subclass_of: Macrocyclic Compounds
Synonym: Cyclic Olefins
Synonym: Cycloalkanes
Synonym: Cycloparaffin
Synonym: Cycloparaffin (substance)
Synonym: Cycloparaffins [Chemical/Ingredient]
Synonym: Olefins, Cyclic
Synonym: cycloalkanes
Synonym: cycloparaffins
Tree Number: T6.4.5.2
database_cross_reference: AOD:0000019653
database_cross_reference: AOD:0000019670
database_cross_reference: LCH:U001234
database_cross_reference: LCH_NW:sh85035091
database_cross_reference: MSH:D003516
database_cross_reference: NDFRT:N0000007896
database_cross_reference: SNOMEDCT_US:126067003

Azulenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00543361
PMOID: PMO:00016728
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Azulenes [Chemical/Ingredient]
Tree Number: T6.4.3.11
database_cross_reference: MSH:D052176
database_cross_reference: NDFRT:N0000167353

Cyclohexanones
type: Class
subclass of: Ketones
MCID: MC00003417
PMOID: PMO:00016733
Subclass_of: Ketones
Synonym: Cyclohexanones [Chemical/Ingredient]
Tree Number: T6.2.20.7
database_cross_reference: LCH_NW:sh2006005740
database_cross_reference: MSH:D003512
database_cross_reference: NDFRT:N0000011466

Picrotoxin
type: Class
subclass of: Lactones
MCID: MC00010209
PMOID: PMO:00016735
Subclass_of: Lactones
Synonym: 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8
Synonym: 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1)
Synonym: Picrotoxin (substance)
Synonym: Picrotoxin [Chemical/Ingredient]
Synonym: cocculin
Synonym: picrotoxin
Synonym: picrotoxins
Tree Number: T6.2.21.2
database_cross_reference: AOD:0000019375
database_cross_reference: CHV:0000009729
database_cross_reference: CSP:2948-5430
database_cross_reference: DRUGBANK:DB00466
database_cross_reference: LCH:U003676
database_cross_reference: LCH_NW:sh85101980
database_cross_reference: MSH:D010852
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:001378
database_cross_reference: NDFRT:N0000168439
database_cross_reference: PSY:38800
database_cross_reference: SNM:E-8807
database_cross_reference: SNMI:C-655D5
database_cross_reference: SNOMEDCT_US:57979006

Tiletamine
type: Class
subclass of: Cyclohexanones
subclass of: Thiophenes
MCID: MC00012859
PMOID: PMO:00016736
Subclass_of: Cyclohexanones
Subclass_of: Thiophenes
Synonym: 2-(Ethylamino)-2-(2-thienyl)cyclohexanone
Synonym: Cyclohexanone, 2-(ethylamino)-2-(2-thienyl)-
Synonym: TILETAMINE
Synonym: Tiletamine [Chemical/Ingredient]
Synonym: tiletamine
Tree Number: T6.2.20.7.1
Tree Number: T6.2.32.22.13
Tree Number: T6.3.5.25.12
database_cross_reference: CHV:0000012288
database_cross_reference: MSH:D013992
database_cross_reference: MTHSPL:2YFC543249
database_cross_reference: NCI:C84211
database_cross_reference: NCI_FDA:2YFC543249
database_cross_reference: NDFRT:N0000167171
database_cross_reference: RXNORM:1535217

Cycloleucine
type: Class
subclass of: PMO:00021266
MCID: MC00003421
PMOID: PMO:00016739
Subclass_of: Amino Acids, Cyclic
Synonym: 1 Aminocyclopentanecarboxylic Acid
Synonym: 1-Amino-1-cyclopentanecarboxylic acid
Synonym: 1-Amino-cyclopentanecarboxylic acid
Synonym: 1-Aminocyclopentane
Synonym: 1-Aminocyclopentane-1-carboxylic acid
Synonym: 1-Aminocyclopentanecarboxylate
Synonym: 1-Aminocyclopentanecarboxylic Acid
Synonym: 1-Aminocyclopentanecarboxylic acid
Synonym: 1-aminocyclopentanecarboxylic acid
Synonym: ACP
Tree Number: T6.10.1.4.1
database_cross_reference: CHV:0000003527
database_cross_reference: DRUGBANK:DB04620
database_cross_reference: MSH:D003515
database_cross_reference: MTH:U001839
database_cross_reference: NCI:C404
database_cross_reference: NCI_DTP:NSC0001026
database_cross_reference: NCI_FDA:0TQU7668EI
database_cross_reference: NDFRT:N0000170255
database_cross_reference: PDQ:CDR0000039200

Hypoglycins
type: Class
subclass of: PMO:00024382
MCID: MC00006614
PMOID: PMO:00016741
Subclass_of: Toxins, Biological
Synonym: Hypoglycins [Chemical/Ingredient]
Tree Number: T6.13.8.4
database_cross_reference: MSH:D007005
database_cross_reference: NDFRT:N0000171469

Albumin-Bound Paclitaxel
type: Class
subclass of: PMO:00021885
MCID: MC00632211
PMOID: PMO:00016748
Subclass_of: Albumins
Synonym: Albumin Bound Paclitaxel
Synonym: Albumin bound paclitaxel
Synonym: Albumin bound paclitaxel (substance)
Synonym: Albumin-Bound Paclitaxel [Chemical/Ingredient]
Synonym: Albumin-bound Paclitaxel
Synonym: PACLitaxel protein-bound
Synonym: Paclitaxel, Albumin-Bound
Synonym: Paclitaxel, Protein-Bound
Synonym: Protein Bound Paclitaxel
Synonym: Protein-Bound Paclitaxel
Tree Number: T6.10.3.7.1
database_cross_reference: MEDCIN:301142
database_cross_reference: MMSL:19175
database_cross_reference: MMSL:d05427
database_cross_reference: MSH:D000068196
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2688
database_cross_reference: NCI_NCI-GLOSS:CDR0000507600
database_cross_reference: NCI_NCI-GLOSS:CDR0000507601
database_cross_reference: NCI_NCI-GLOSS:CDR0000507751
database_cross_reference: NDDF:008823
database_cross_reference: NDFRT:N0000191965
database_cross_reference: RXNORM:486610
database_cross_reference: SNOMEDCT_US:426653008

Hydrocarbons, Aromatic
type: Class
subclass of: Hydrocarbons, Cyclic
MCID: MC00006448
PMOID: PMO:00016750
Subclass_of: Hydrocarbons, Cyclic
Synonym: Aromatic Hydrocarbon
Synonym: Aromatic Hydrocarbons
Synonym: Aromatic hydrocarbon
Synonym: Aromatic hydrocarbon (substance)
Synonym: Aromatic hydrocarbon, NOS
Synonym: Hydrocarbons, Aromatic [Chemical/Ingredient]
Synonym: aromatic hydrocarbon
Synonym: aromatic hydrocarbons
Tree Number: T6.2.17.2.3
database_cross_reference: AOD:0000019680
database_cross_reference: CHV:0000006340
database_cross_reference: MSH:D006841
database_cross_reference: NCI:C553
database_cross_reference: NDFRT:N0000008229
database_cross_reference: RCD:Xa7NZ
database_cross_reference: SNM:E-5440
database_cross_reference: SNMI:C-20700
database_cross_reference: SNOMEDCT_US:34862004

Ferrozine
type: Class
subclass of: Triazines
MCID: MC00005053
PMOID: PMO:00016757
Subclass_of: Triazines
Synonym: Benzenesulfonic acid, 4,4'-(3-(2-pyridinyl)-1,2,4-triazine-5,6-diyl)bis-, disodium salt
Synonym: Ferrozine [Chemical/Ingredient]
Tree Number: T6.3.5.26.3
database_cross_reference: MSH:D005297
database_cross_reference: NDFRT:N0000167160

Polyanetholesulfonate
type: Class
subclass of: Polymers
MCID: MC00010398
PMOID: PMO:00016758
Subclass_of: Polymers
Synonym: Benzene, 1-methoxy-4-(1-propenyl)-, (E)-, homopolymer, sulfonated, sodium salt
Synonym: Polyanethol Sulfonate
Synonym: Polyanetholesulfonate [Chemical/Ingredient]
Synonym: Sulfonate, Polyanethol
Tree Number: T6.14.9.7
Tree Number: T6.5.2.9
database_cross_reference: MSH:D011074
database_cross_reference: NDFRT:N0000171534

Meclizine
type: Class
subclass of: Piperazines
MCID: MC00007950
PMOID: PMO:00016761
Subclass_of: Piperazines
Synonym: 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
Synonym: Antivert Tab
Synonym: Bonamine Tab 25mg Chewable
Synonym: CVS Motion Sickness Fast Melting
Synonym: Less Drowsy Formula Motion Sickness Relief
Synonym: Less Drowsy Motion Sickness Relief
Synonym: MECLIZINE
Synonym: Meclizine (product)
Synonym: Meclizine (substance)
Synonym: Meclizine 25
Tree Number: T6.3.5.15.20
database_cross_reference: ATC:R06AE05
database_cross_reference: CHV:0000007829
database_cross_reference: DRUGBANK:DB00737
database_cross_reference: LNC:LP18131-0
database_cross_reference: LNC:MTHU003449
database_cross_reference: MMSL:d00859
database_cross_reference: MSH:D008468
database_cross_reference: MTHSPL:3L5TQ84570
database_cross_reference: NCI:C61610
database_cross_reference: NCI_FDA:3L5TQ84570
database_cross_reference: NDDF:004798
database_cross_reference: NDFRT:N0000006431
database_cross_reference: NDFRT:N0000147898
database_cross_reference: RXNORM:6676
database_cross_reference: SNM:E-8243
database_cross_reference: SNMI:C-51860
database_cross_reference: SNOMEDCT_US:372879002
database_cross_reference: SNOMEDCT_US:84951002
database_cross_reference: USPMG:MTHU000367
database_cross_reference: VANDF:4019809

Terfenadine
type: Class
subclass of: Piperidines
MCID: MC00043189
PMOID: PMO:00016762
Subclass_of: Piperidines
Synonym: (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol
Synonym: 1-Piperidinebutanol, alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-
Synonym: Apo-terfenadine Tab 120mg
Synonym: Apo-terfenadine Tablets 60mg
Synonym: Bronal
Synonym: Daylert
Synonym: Novo-terfenadine Tab 60mg
Synonym: Pharmaplus Once A Day Allergy Caplet 120mg
Synonym: Seldane - Sus 30mg/5ml
Synonym: Seldane - Tab 60mg
Tree Number: T6.3.5.16.28
database_cross_reference: ATC:R06AX12
database_cross_reference: CHV:0000015478
database_cross_reference: DRUGBANK:DB00342
database_cross_reference: LNC:LP18101-3
database_cross_reference: LNC:MTHU003387
database_cross_reference: MMSL:2365
database_cross_reference: MMSL:5550
database_cross_reference: MMSL:d00387
database_cross_reference: MSH:D016593
database_cross_reference: NCI:C29494
database_cross_reference: NCI_DCP:20184
database_cross_reference: NCI_FDA:7BA5G9Y06Q
database_cross_reference: NDDF:003412
database_cross_reference: NDFRT:N0000007398
database_cross_reference: NDFRT:N0000147493
database_cross_reference: RCD:c8j..
database_cross_reference: RXNORM:42330
database_cross_reference: SNMI:C-51050
database_cross_reference: SNOMEDCT_US:16037009
database_cross_reference: SNOMEDCT_US:387089004
database_cross_reference: VANDF:4019295

Benzophenones
type: Class
subclass of: Ketones
MCID: MC00001591
PMOID: PMO:00016763
Subclass_of: Ketones
Synonym: Benzophenones [Chemical/Ingredient]
Tree Number: T6.2.20.3
database_cross_reference: MSH:D001577
database_cross_reference: NDFRT:N0000007552

2-Hydroxy-5-nitrobenzyl Bromide
type: Class
subclass of: Nitrophenols
MCID: MC00000041
PMOID: PMO:00016766
Subclass_of: Nitrophenols
Synonym: 2 Hydroxy 5 nitrobenzyl Bromide
Synonym: 2-Hydroxy-5-nitrobenzyl Bromide [Chemical/Ingredient]
Synonym: HYDROXYNITROBENZYL BROMIDE 02 05
Synonym: KOSHLANDS REAGENT 01
Synonym: Koshland Reagent
Synonym: Koshland Reagent I
Synonym: Koshland's Reagent I
Synonym: Koshlands Reagent
Synonym: Koshlands Reagent I
Synonym: Phenol, 2-(bromomethyl)-4-nitro-
Tree Number: T6.2.25.7.6
database_cross_reference: MSH:D015077
database_cross_reference: NDFRT:N0000166603

4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid
type: Class
subclass of: Isothiocyanates
MCID: MC00011905
PMOID: PMO:00016779
Subclass_of: Isothiocyanates
Synonym: 4 Acetamido 4' isothiocyanatostilbene 2,2' disulfonic Acid
Synonym: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid [Chemical/Ingredient]
Synonym: 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid (SITS)
Synonym: ACETAMIDOISOTHIOCYANATOSTILBENEDISULFONIC ACID 04 04 02 02
Synonym: Benzenesulfonic acid, 5-(acetylamino)-2-(2-(4-isothiocyanato-2-sulfophenyl)ethenyl)-
Synonym: SITS
Tree Number: T6.2.32.26.1
Tree Number: T6.2.37.2.1
database_cross_reference: CHV:0000011377
database_cross_reference: MSH:D012856
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166553

4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
type: Class
subclass of: Isothiocyanates
MCID: MC00024860
PMOID: PMO:00016783
Subclass_of: Isothiocyanates
Synonym: 4,4'-Diisothiocyano-2,2'-Stilbene Disulfonic Acid
Synonym: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid [Chemical/Ingredient]
Synonym: Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis(5-isothiocyanato)-
Synonym: DIDS
Synonym: DIISOTHIOCYANOSTILBENEDISULFONIC ACID 04 04 02 02
Tree Number: T6.2.32.26.4
Tree Number: T6.2.37.2.4
database_cross_reference: MSH:D017878
database_cross_reference: NDFRT:N0000166552

Polystyrenes
type: Class
subclass of: Plastics
MCID: MC00010472
PMOID: PMO:00016786
Subclass_of: Plastics
Synonym: Polystyrene
Synonym: Polystyrene (substance)
Synonym: Polystyrenes [Chemical/Ingredient]
Synonym: Polystyrol
Synonym: Polystyrols
Synonym: polystyrene
Tree Number: T6.14.9.6.4
Tree Number: T6.5.2.8.4
database_cross_reference: CHV:0000009946
database_cross_reference: CSP:2349-0867
database_cross_reference: LCH_NW:sh2002004630
database_cross_reference: MSH:D011137
database_cross_reference: NDFRT:N0000007840
database_cross_reference: RCD:Ub1Xz
database_cross_reference: SNMI:C-2A520
database_cross_reference: SNOMEDCT_US:47358009

Tyrphostins
type: Class
subclass of: Nitriles
MCID: MC00184334
PMOID: PMO:00016787
Subclass_of: Nitriles
Synonym: Tyrphostins [Chemical/Ingredient]
Synonym: tyrphostin
Synonym: tyrphostins
Tree Number: T6.2.23.14
database_cross_reference: CHV:0000042272
database_cross_reference: MSH:D020032
database_cross_reference: NDFRT:N0000166940

Niclofolan
type: Class
subclass of: Nitrophenols
MCID: MC00008879
PMOID: PMO:00016793
Subclass_of: Nitrophenols
Synonym: (1,1'-Biphenyl)-2,2'-diol, 5,5'-dichloro-3,3'-dinitro-
Synonym: Menichlopholan
Synonym: NICLOFOLAN
Synonym: Niclofan
Synonym: Niclofolan [Chemical/Ingredient]
Tree Number: T6.2.25.7.2
database_cross_reference: MSH:D009533
database_cross_reference: NCI:C75223
database_cross_reference: NCI_FDA:82KFT81F6W
database_cross_reference: NDFRT:N0000166602

Nitrobenzenes
type: Class
subclass of: Nitro Compounds
MCID: MC00008930
PMOID: PMO:00016810
Subclass_of: Nitro Compounds
Synonym: Nitrobenzene
Synonym: Nitrobenzenes [Chemical/Ingredient]
Tree Number: T6.2.25.3
database_cross_reference: LCH_NW:sh97009279
database_cross_reference: MSH:D009578
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007652

Dinitrobenzenes
type: Class
subclass of: Nitrobenzenes
MCID: MC00003975
PMOID: PMO:00016811
Subclass_of: Nitrobenzenes
Synonym: Dinitrobenzene
Synonym: Dinitrobenzene (substance)
Synonym: Dinitrobenzenes [Chemical/Ingredient]
Synonym: dinitrobenzene
Tree Number: T6.2.25.3.2
database_cross_reference: CSP:2075-0967
database_cross_reference: LCH_NW:sh96010945
database_cross_reference: LNC:LP15541-3
database_cross_reference: LNC:MTHU010537
database_cross_reference: MSH:D004136
database_cross_reference: NDFRT:N0000166573
database_cross_reference: SNM:E-5737
database_cross_reference: SNMI:C-21907
database_cross_reference: SNOMEDCT_US:60303002

Trinitrobenzenes
type: Class
subclass of: Nitrobenzenes
MCID: MC00013120
PMOID: PMO:00016813
Subclass_of: Nitrobenzenes
Synonym: Compounds, Trinitrophenyl
Synonym: TRINITROPHENYL CPDS
Synonym: Trinitrobenzenes [Chemical/Ingredient]
Synonym: Trinitrophenyl Compounds
Tree Number: T6.2.25.3.3
database_cross_reference: MSH:D014301
database_cross_reference: NDFRT:N0000166575

Dinitrocresols
type: Class
subclass of: Nitro Compounds
MCID: MC00003978
PMOID: PMO:00016832
Subclass_of: Nitro Compounds
Synonym: Dinitrocresols [Chemical/Ingredient]
Tree Number: T6.2.25.1
database_cross_reference: MSH:D004138
database_cross_reference: NDFRT:N0000166611

Tritolyl Phosphates
type: Class
subclass of: Organophosphates
MCID: MC00013140
PMOID: PMO:00016833
Subclass_of: Organophosphates
Synonym: Phosphate, Tricresyl
Synonym: Phosphate, Tritolyl
Synonym: Phosphates, Tricresyl
Synonym: Phosphates, Tritolyl
Synonym: Tricresyl Phosphate
Synonym: Tricresyl Phosphates
Synonym: Tricresyl phosphate
Synonym: Tricresyl phosphate (product)
Synonym: Tricresyl phosphate (substance)
Synonym: Tritolyl Phosphate
Tree Number: T6.2.29.5.12
database_cross_reference: MSH:D014317
database_cross_reference: NDFRT:N0000166614
database_cross_reference: RCD:X79K2
database_cross_reference: SNOMEDCT_US:256074005
database_cross_reference: SNOMEDCT_US:411417003

Nitrophenols
type: Class
subclass of: Nitro Compounds
MCID: MC00008951
PMOID: PMO:00016838
Subclass_of: Nitro Compounds
Synonym: Nitrophenols [Chemical/Ingredient]
Tree Number: T6.2.25.7
database_cross_reference: LCH_NW:sh93006725
database_cross_reference: MSH:D009596
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166599

Dinitrophenols
type: Class
subclass of: Nitrophenols
MCID: MC00003980
PMOID: PMO:00016839
Subclass_of: Nitrophenols
Synonym: Dinitrophenol
Synonym: Dinitrophenol (substance)
Synonym: Dinitrophenols [Chemical/Ingredient]
Synonym: dinitrophenol
Tree Number: T6.2.25.7.1
database_cross_reference: CHV:0000003969
database_cross_reference: DRUGBANK:DB04528
database_cross_reference: LCH:U001403
database_cross_reference: LCH_NW:sh85038073
database_cross_reference: LNC:LP18948-7
database_cross_reference: LNC:MTHU006971
database_cross_reference: MSH:D004140
database_cross_reference: NDFRT:N0000166600
database_cross_reference: SNM:E-5746
database_cross_reference: SNMI:C-21915
database_cross_reference: SNOMEDCT_US:19964006

Nitrohydroxyiodophenylacetate
type: Class
subclass of: Nitrophenols
MCID: MC00008945
PMOID: PMO:00016841
Subclass_of: Nitrophenols
Synonym: (4-Hydroxy-3-iodo-5-nitrophenyl)acetyl
Synonym: (4-Hydroxy-5-iodo-3-nitrophenyl)acetyl
Synonym: 5 Iodo 4 hydroxy 3 nitrophenacetyl
Synonym: 5-Iodo-4-hydroxy-3-nitrophenacetyl
Synonym: Acetyl Hapten, NIP
Synonym: Benzeneacetic acid, 4-hydroxy-3-iodo-5-nitro-
Synonym: Hapten, NIP Acetyl
Synonym: Hydroxyiodonitrophenylacetate
Synonym: NIP Acetyl Hapten
Synonym: NIP Hapten
Tree Number: T6.2.25.7.3
database_cross_reference: MSH:D009592
database_cross_reference: NDFRT:N0000171187

Nitroxinil
type: Class
subclass of: Nitrophenols
MCID: MC00008966
PMOID: PMO:00016842
Subclass_of: Nitrophenols
Synonym: Benzonitrile, 4-hydroxy-3-iodo-5-nitro-
Synonym: NITROXINIL
Synonym: Nitroxinil [Chemical/Ingredient]
Synonym: Nitroxynil
Tree Number: T6.2.25.7.4
database_cross_reference: MSH:D009611
database_cross_reference: NCI:C75227
database_cross_reference: NCI_FDA:9L0EXQ7125
database_cross_reference: NDFRT:N0000166605

Picrates
type: Class
subclass of: Nitrophenols
MCID: MC00010208
PMOID: PMO:00016843
Subclass_of: Nitrophenols
Synonym: Picrates [Chemical/Ingredient]
Tree Number: T6.2.25.7.5
database_cross_reference: MSH:D010851
database_cross_reference: NDFRT:N0000166604

Polyphloretin Phosphate
type: Class
subclass of: Polymers
MCID: MC00010452
PMOID: PMO:00016851
Subclass_of: Polymers
Synonym: 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, phosphate, homopolymer
Synonym: Phosphate, Polyphloretin
Synonym: Polyphloretin Phosphate [Chemical/Ingredient]
Tree Number: T6.14.9.11
Tree Number: T6.5.2.13
database_cross_reference: MSH:D011121
database_cross_reference: NDFRT:N0000171549

Zearalenone
type: Class
subclass of: Lactones
subclass of: PMO:00024389
MCID: MC00013797
PMOID: PMO:00016856
Subclass_of: Lactones
Subclass_of: Mycotoxins
Synonym: 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,5,6,9,10-hexahydro-14,16-dihydroxy-3-methyl-, (S-(E))-
Synonym: F 2 Toxin
Synonym: F A 02 TOXIN
Synonym: F-2 Toxin
Synonym: F-2 toxin
Synonym: F2 Toxin
Synonym: Toxin, F-2
Synonym: Toxin, F2
Synonym: Zearalenone (substance)
Synonym: Zearalenone [Chemical/Ingredient]
Tree Number: T6.13.8.6.16
Tree Number: T6.2.21.6
database_cross_reference: MSH:D015025
database_cross_reference: NDFRT:N0000171426
database_cross_reference: SNMI:C-30833
database_cross_reference: SNOMEDCT_US:73741007

Zeranol
type: Class
subclass of: Zearalenone
MCID: MC00013801
PMOID: PMO:00016857
Subclass_of: Zearalenone
Synonym: 1H-2-Benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-, (3S-(3R*,7S*))-
Synonym: Xeranol
Synonym: ZERANOL
Synonym: Zearalanol
Synonym: Zearanol
Synonym: Zeranol (substance)
Synonym: Zeranol [Chemical/Ingredient]
Synonym: Zeranol preparation
Synonym: Zeranol preparation (product)
Synonym: Zeranol preparation (substance)
Tree Number: T6.2.21.6.1
database_cross_reference: LCH:U005084
database_cross_reference: LCH_NW:sh85149756
database_cross_reference: MSH:D015029
database_cross_reference: MTHSPL:76LO2L2V39
database_cross_reference: NCI:C76826
database_cross_reference: NCI_FDA:76LO2L2V39
database_cross_reference: NDFRT:N0000166852
database_cross_reference: RXNORM:1368476
database_cross_reference: SNMI:C-A05A1
database_cross_reference: SNOMEDCT_US:126176008
database_cross_reference: SNOMEDCT_US:96340007

Aspirin, Dipyridamole Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00249010
PMOID: PMO:00016862
Subclass_of: Drug Combinations
Synonym: ASPIRIN/DIPYRIDAMOLE
Synonym: Aspirin + Dipyridamole
Synonym: Aspirin / Dipyridamole
Synonym: Aspirin Dipyridamole Drug Combination
Synonym: Aspirin and Dipyridamole
Synonym: Aspirin, Dipyridamole Drug Combination [Chemical/Ingredient]
Synonym: Aspirin-Dipyridamole Drug Combination
Synonym: Combination, Aspirin-Dipyridamole Drug
Synonym: Dipyridamole and Aspirin
Synonym: Dipyridamole+aspirin
Tree Number: T6.15.3.3
database_cross_reference: DRUGBANK:DB00945
database_cross_reference: DRUGBANK:DB00975
database_cross_reference: MEDCIN:191428
database_cross_reference: MMSL:d04497
database_cross_reference: MSH:D000068342
database_cross_reference: NDFRT:N0000022178
database_cross_reference: NDFRT:N0000191933
database_cross_reference: RCD:bu4..
database_cross_reference: RXNORM:226716
database_cross_reference: SNOMEDCT_US:319796006
database_cross_reference: USPMG:MTHU002820
database_cross_reference: VANDF:4024173

Phenylurea Compounds
type: Class
subclass of: Urea
MCID: MC00010063
PMOID: PMO:00016865
Subclass_of: Urea
Synonym: Compounds, Phenylurea
Synonym: Derivatives, Phenylurea
Synonym: PHENYLUREA CPDS
Synonym: Phenylcarbamides
Synonym: Phenylurea Compounds [Chemical/Ingredient]
Synonym: Phenylurea Derivatives
Tree Number: T6.2.34.8
database_cross_reference: MSH:D010671
database_cross_reference: NDFRT:N0000166301

Diflubenzuron
type: Class
subclass of: Phenylurea Compounds
MCID: MC00003971
PMOID: PMO:00016866
Subclass_of: Phenylurea Compounds
Synonym: Benzamide, N-(((4-chlorophenyl)amino)carbonyl)-2,6-difluoro-
Synonym: Diflubenzuron [Chemical/Ingredient]
Synonym: Dioflubenzuron
Synonym: diflubenzuron
Tree Number: T6.2.34.8.2
database_cross_reference: MSH:D004132
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167492
database_cross_reference: RXNORM:1665336

Diuron
type: Class
subclass of: Phenylurea Compounds
MCID: MC00004087
PMOID: PMO:00016867
Subclass_of: Phenylurea Compounds
Synonym: 3-(3,4-Dichlorophenyl)-1,1-dimethylurea
Synonym: DCMU
Synonym: Dichlorophenyl dimethyl urea
Synonym: Dichlorophenyl dimethyl urea (substance)
Synonym: Diuron [Chemical/Ingredient]
Synonym: Urea, N'-(3,4-dichlorophenyl)-N,N-dimethyl-
Tree Number: T6.2.34.8.3
database_cross_reference: LCH:U001437
database_cross_reference: LCH_NW:sh85038569
database_cross_reference: MSH:D004237
database_cross_reference: NDFRT:N0000166302
database_cross_reference: SNM:E-6475
database_cross_reference: SNMI:C-23517
database_cross_reference: SNOMEDCT_US:22551004

Linuron
type: Class
subclass of: Phenylurea Compounds
MCID: MC00007581
PMOID: PMO:00016868
Subclass_of: Phenylurea Compounds
Synonym: Linuron (substance)
Synonym: Linuron [Chemical/Ingredient]
Synonym: Methoxydiuron
Synonym: Urea, N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl-
Tree Number: T6.2.34.8.4
database_cross_reference: MSH:D008044
database_cross_reference: NDFRT:N0000166303
database_cross_reference: SNMI:C-23554
database_cross_reference: SNOMEDCT_US:72773006

Toluene 2,4-Diisocyanate
type: Class
subclass of: Isocyanates
MCID: MC00012904
PMOID: PMO:00016874
Subclass_of: Isocyanates
Synonym: 2,4 Toluenediisocyanate
Synonym: 2,4-Diisocyanate, Toluene
Synonym: 2,4-Toluene diisocyanate
Synonym: 2,4-Toluenediisocyanate
Synonym: Benzene, 2,4-diisocyanato-1-methyl-
Synonym: TOLUENE DIISOCYANATE 02 04
Synonym: Toluene 2,4 Diisocyanate
Synonym: Toluene 2,4-Diisocyanate [Chemical/Ingredient]
Synonym: Toluene-2-4-diisocyanate
Synonym: Toluene-2-4-diisocyanate (substance)
Tree Number: T6.2.37.1
database_cross_reference: LNC:LP34856-2
database_cross_reference: LNC:MTHU027476
database_cross_reference: MSH:D014051
database_cross_reference: NDFRT:N0000166550
database_cross_reference: SNMI:C-20713
database_cross_reference: SNOMEDCT_US:20564006

Tosyl Compounds
type: Class
subclass of: Sulfones
MCID: MC00012939
PMOID: PMO:00016875
Subclass_of: Sulfones
Synonym: Compounds, Toluenesulfonyl
Synonym: Compounds, Tosyl
Synonym: TOLUENESULFONYL CPDS
Synonym: TOSYL CPDS
Synonym: Toluenesulfonyl Compounds
Synonym: Tosyl Compounds [Chemical/Ingredient]
Tree Number: T6.2.32.8.6
database_cross_reference: MSH:D014105
database_cross_reference: NDFRT:N0000008020

Tosyllysine Chloromethyl Ketone
type: Class
subclass of: PMO:00021260
MCID: MC00012941
PMOID: PMO:00016877
Subclass_of: Amino Acid Chloromethyl Ketones
Synonym: Benzenesulfonamide, N-(5-amino-1-(chloroacetyl)pentyl)-4-methyl-
Synonym: Chloromethane, Tosyllysyl
Synonym: Chloromethyl Ketone, Tosyllysine
Synonym: Chlorotosylamidoaminoheptanone
Synonym: Ketone, Tosyllysine Chloromethyl
Synonym: TLCK
Synonym: Tosyllysine Chloromethyl Ketone [Chemical/Ingredient]
Synonym: Tosyllysyl Chloromethane
Tree Number: T6.10.1.2.1
database_cross_reference: MSH:D014107
database_cross_reference: NDFRT:N0000170227

Tosylphenylalanyl Chloromethyl Ketone
type: Class
subclass of: PMO:00021260
MCID: MC00012942
PMOID: PMO:00016878
Subclass_of: Amino Acid Chloromethyl Ketones
Synonym: Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-
Synonym: Chloromethane, Tosylphenylalanyl
Synonym: Chloromethyl Ketone, Tosylphenylalanyl
Synonym: Chlorophenyltosylamidobutanone
Synonym: Ketone, Tosylphenylalanyl Chloromethyl
Synonym: TPCK
Synonym: Tosylphenylalanyl Chloromethane
Synonym: Tosylphenylalanyl Chloromethyl Ketone [Chemical/Ingredient]
Tree Number: T6.10.1.2.2
database_cross_reference: MSH:D014108
database_cross_reference: NDFRT:N0000170226

Polycyclic Aromatic Hydrocarbons
type: Class
subclass of: Polycyclic Compounds
MCID: MC00010406
PMOID: PMO:00016883
Subclass_of: Polycyclic Compounds
Synonym: Aromatic Hydrocarbons, Polycyclic
Synonym: Aromatic Hydrocarbons, Polynuclear
Synonym: Aromatic Polycyclic Hydrocarbons
Synonym: Hydrocarbons, Aromatic Polycyclic
Synonym: Hydrocarbons, Polycyclic Aromatic
Synonym: Hydrocarbons, Polynuclear Aromatic
Synonym: PAH
Synonym: PAH (polynuclear aromatic hydrocarbon)
Synonym: Polycyclic Aromatic Hydrocarbons [Chemical/Ingredient]
Synonym: Polycyclic Hydrocarbons, Aromatic
Tree Number: T6.4.3
database_cross_reference: AOD:0000019775
database_cross_reference: CHV:0000009908
database_cross_reference: CSP:0779-4894
database_cross_reference: LCH_NW:sh85104606
database_cross_reference: MSH:D011084
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C761
database_cross_reference: NDFRT:N0000008164

Anthracenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00000977
PMOID: PMO:00016884
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Anthracenes [Chemical/Ingredient]
Tree Number: T6.4.3.1
database_cross_reference: MSH:D000873
database_cross_reference: NDFRT:N0000007574

Anthralin
type: Class
subclass of: Anthracenes
MCID: MC00000980
PMOID: PMO:00016885
Subclass_of: Anthracenes
Synonym: 1,8 Dihydroxy 9 anthrone
Synonym: 1,8,9-Anthracenetriol
Synonym: 1,8-Dihydroxy-9(10H)-anthracenone
Synonym: 1,8-Dihydroxy-9-anthrone
Synonym: ANTHRALIN
Synonym: Anthraforte 1 Ointment 1%
Synonym: Anthraforte 2 Ointment 2%
Synonym: Anthralin (product)
Synonym: Anthralin (substance)
Synonym: Anthralin [Chemical/Ingredient]
Tree Number: T6.4.3.1.1
database_cross_reference: ATC:D05AC01
database_cross_reference: CHV:0000001243
database_cross_reference: DRUGBANK:DB11157
database_cross_reference: MEDCIN:40744
database_cross_reference: MMSL:24
database_cross_reference: MMSL:4206
database_cross_reference: MSH:D000875
database_cross_reference: MTHSPL:U8CJK0JH5M
database_cross_reference: NCI:C28827
database_cross_reference: NCI_DCP:00828
database_cross_reference: NCI_FDA:U8CJK0JH5M
database_cross_reference: NDDF:001984
database_cross_reference: NDFRT:N0000006034
database_cross_reference: NDFRT:N0000146914
database_cross_reference: RCD:m53..
database_cross_reference: RCD:m5z..
database_cross_reference: RXNORM:873
database_cross_reference: SNM:E-8001
database_cross_reference: SNMI:C-92420
database_cross_reference: SNOMEDCT_US:332227001
database_cross_reference: SNOMEDCT_US:387293003
database_cross_reference: SNOMEDCT_US:53800008
database_cross_reference: VANDF:4018598

Anthraquinones
type: Class
subclass of: Anthracenes
subclass of: Quinones
MCID: MC00000986
PMOID: PMO:00016886
Subclass_of: Anthracenes
Subclass_of: Quinones
Synonym: Anthracenedione
Synonym: Anthracenediones
Synonym: Anthranoids
Synonym: Anthraquinone
Synonym: Anthraquinone (substance)
Synonym: Anthraquinone Analogue
Synonym: Anthraquinone Compound
Synonym: Anthraquinone Compounds
Synonym: Anthraquinone Derivatives
Synonym: Anthraquinones [Chemical/Ingredient]
Tree Number: T6.2.30.1
Tree Number: T6.4.3.1.2
database_cross_reference: CHV:0000001245
database_cross_reference: LCH:U000274
database_cross_reference: LCH_NW:sh85005561
database_cross_reference: LNC:LP16038-9
database_cross_reference: LNC:MTHU015517
database_cross_reference: MSH:D000880
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C253
database_cross_reference: NCI_NCI-GLOSS:CDR0000045594
database_cross_reference: NCI_NCI-GLOSS:CDR0000045595
database_cross_reference: NDFRT:N0000007583
database_cross_reference: SNM:E-6446
database_cross_reference: SNOMEDCT_US:116283009

Carmine
type: Class
subclass of: Anthraquinones
MCID: MC00002326
PMOID: PMO:00016887
Subclass_of: Anthraquinones
Synonym: 2-Anthracenecarboxylic acid, 7-beta-D-glucopyranosyl-9,10-dihydro-3,5,6,8-tetrahydroxy-1-methyl-9,10-dioxo-
Synonym: 7-Glucopyranosyl-3,5,6,8-tetrahydroxyl-1-methyl-9,10-dioxoanthracene-2-carboxylic Acid
Synonym: Carmine (substance)
Synonym: Carmine [Chemical/Ingredient]
Synonym: Carmine stain
Synonym: Carmine stain (substance)
Synonym: Cochineal Dye
Synonym: Dye, Cochineal
Synonym: Natural Red 4
Synonym: carmine
Tree Number: T6.2.30.1.1
database_cross_reference: CHV:0000002466
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D002329
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:002629
database_cross_reference: NDFRT:N0000167362
database_cross_reference: SNMI:C-22971
database_cross_reference: SNOMEDCT_US:73892005

Cascara
type: Class
subclass of: Anthraquinones
MCID: MC00067106
PMOID: PMO:00016888
Subclass_of: Anthraquinones
Synonym: CASCARA SAGRADA
Synonym: CASCARA SAGRADA EXTRACT
Synonym: CASCARA SAGRADA ORAL FLUID EXTRACT
Synonym: CASCARA SAGRADA@@ORAL@FLUID EXTRACT
Synonym: Cascara (product)
Synonym: Cascara (substance)
Synonym: Cascara Sagrada
Synonym: Cascara Sagrada Fluid Extract
Synonym: Cascara [Chemical/Ingredient]
Synonym: Cascara sagrada
Tree Number: T6.2.30.1.2
database_cross_reference: ATC:A06AB07
database_cross_reference: CHV:0000020687
database_cross_reference: LCH:U000826
database_cross_reference: LCH_NW:sh00006751
database_cross_reference: MEDCIN:40909
database_cross_reference: MMSL:4365
database_cross_reference: MMSL:4366
database_cross_reference: MMSL:6007
database_cross_reference: MMSL:6008
database_cross_reference: MMSL:d01010
database_cross_reference: MSH:D002362
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:001168
database_cross_reference: NDDF:002894
database_cross_reference: NDDF:014277
database_cross_reference: NDFRT:N0000006762
database_cross_reference: NDFRT:N0000147280
database_cross_reference: NDFRT:N0000147323
database_cross_reference: RCD:ac2..
database_cross_reference: RXNORM:66869
database_cross_reference: SNM:E-8261
database_cross_reference: SNMI:C-84822
database_cross_reference: SNOMEDCT_US:23888001
database_cross_reference: SNOMEDCT_US:387128007
database_cross_reference: VANDF:4019004
database_cross_reference: VANDF:4019055

Mitoxantrone
type: Class
subclass of: Anthraquinones
MCID: MC00008357
PMOID: PMO:00016890
Subclass_of: Anthraquinones
Synonym: 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione
Synonym: 1,4-DIHYDROXY-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthracenedione
Synonym: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone
Synonym: 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-
Synonym: DHAD
Synonym: DHAQ
Synonym: Dihydroxyanthracenedione
Synonym: MITOXANTRONE
Synonym: Mitoxantrona
Synonym: Mitoxantrone (product)
Tree Number: T6.2.30.1.3
database_cross_reference: ATC:L01DB07
database_cross_reference: CHV:0000008190
database_cross_reference: CSP:0187-6935
database_cross_reference: DRUGBANK:DB01204
database_cross_reference: MMSL:d00306
database_cross_reference: MSH:D008942
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:BZ114NVM5P
database_cross_reference: NCI:C62050
database_cross_reference: NCI:C665
database_cross_reference: NCI_DTP:NSC0279836
database_cross_reference: NCI_DTP:NSC0301739
database_cross_reference: NCI_FDA:BZ114NVM5P
database_cross_reference: NCI_NCI-GLOSS:CDR0000045192
database_cross_reference: NDDF:004828
database_cross_reference: NDFRT:N0000005740
database_cross_reference: NDFRT:N0000147929
database_cross_reference: PDQ:CDR0000039219
database_cross_reference: RCD:h56..
database_cross_reference: RXNORM:7005
database_cross_reference: SNOMEDCT_US:108791001
database_cross_reference: SNOMEDCT_US:386913001
database_cross_reference: USPMG:MTHU002544
database_cross_reference: VANDF:4019842

Senna Extract
type: Class
subclass of: Anthraquinones
MCID: MC00011742
PMOID: PMO:00016891
Subclass_of: Anthraquinones
Synonym: Extract, Senna
Synonym: SENNA EXTRACT
Synonym: Senna Extract [Chemical/Ingredient]
Synonym: senna extract
Tree Number: T6.2.30.1.4
database_cross_reference: MSH:D012676
database_cross_reference: NCI:C61324
database_cross_reference: NDFRT:N0000005452
database_cross_reference: NDFRT:N0000147575
database_cross_reference: PDQ:CDR0000480408
database_cross_reference: VANDF:4019451

Maprotiline
type: Class
subclass of: Anthracenes
MCID: MC00007907
PMOID: PMO:00016892
Subclass_of: Anthracenes
Synonym: 9,10-Ethanoanthracene-9(10H)-propanamine, N-methyl-
Synonym: Dibencycladine
Synonym: Ludiomil Tab 10mg
Synonym: Ludiomil Tab 25mg
Synonym: Ludiomil Tab 50mg
Synonym: Ludiomil Tab 75mg
Synonym: MAPROTILINE
Synonym: Maprotilin
Synonym: Maprotilina
Synonym: Maprotiline (product)
Tree Number: T6.4.3.1.3
database_cross_reference: AOD:0000019774
database_cross_reference: ATC:N06AA21
database_cross_reference: CHV:0000007742
database_cross_reference: DRUGBANK:DB00934
database_cross_reference: LNC:LP16180-9
database_cross_reference: LNC:MTHU005013
database_cross_reference: MMSL:d00877
database_cross_reference: MSH:D008376
database_cross_reference: MTHSPL:2U1W68TROF
database_cross_reference: NCI:C61824
database_cross_reference: NCI_FDA:2U1W68TROF
database_cross_reference: NDDF:004608
database_cross_reference: NDFRT:N0000007296
database_cross_reference: NDFRT:N0000147895
database_cross_reference: PSY:29527
database_cross_reference: RCD:x01Au
database_cross_reference: RXNORM:6646
database_cross_reference: SNMI:C-62120
database_cross_reference: SNOMEDCT_US:32823007
database_cross_reference: SNOMEDCT_US:387180003
database_cross_reference: USPMG:MTHU000341
database_cross_reference: VANDF:4019806

Benz(a)Anthracenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00519927
PMOID: PMO:00016893
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: BENZANTHRACENES A
Synonym: Benz(a)Anthracenes [Chemical/Ingredient]
Synonym: Benz(b)Phenanthrenes
Synonym: Naphthanthracenes
Tree Number: T6.4.3.2
database_cross_reference: MSH:D001551
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167350

Methylcholanthrene
type: Class
subclass of: Benz(a)Anthracenes
MCID: MC00000047
PMOID: PMO:00016894
Subclass_of: Benz(a)Anthracenes
Synonym: 1,2-Dihydro-3-methyl-benz(j)aceanthrylene
Synonym: 20 Methylcholanthrene
Synonym: 20-Methylcholanthrene
Synonym: 3 Methylcholanthrene
Synonym: 3-Methylcholanthrene
Synonym: MCA
Tree Number: T6.4.3.2.1
database_cross_reference: MSH:D008748
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C29795

Perylene
type: Class
subclass of: Benz(a)Anthracenes
subclass of: Phenalenes
MCID: MC00009963
PMOID: PMO:00016895
Subclass_of: Benz(a)Anthracenes
Subclass_of: Phenalenes
Synonym: Peri Dinaphthalene
Synonym: Peri-Dinaphthalene
Synonym: Perilene
Synonym: Perylene [Chemical/Ingredient]
Tree Number: T6.4.3.10.1
Tree Number: T6.4.3.2.2
database_cross_reference: LCH_NW:sh89003056
database_cross_reference: MSH:D010569
database_cross_reference: NDFRT:N0000167374

9,10-Dimethyl-1,2-benzanthracene
type: Class
subclass of: Benz(a)Anthracenes
MCID: MC00000108
PMOID: PMO:00016896
Subclass_of: Benz(a)Anthracenes
Synonym: 1,4-Dimethyl-2,3-benzphenanthrene
Synonym: 7,12 Dimethylbenzanthracene
Synonym: 7,12-Dimethylbenz(a)anthracene
Synonym: 7,12-Dimethylbenzanthracene
Synonym: 7,12-dimentylbenzanthracene
Synonym: 9,10-Dimethyl-1,2-Benzanthracene
Synonym: 9,10-Dimethyl-1,2-benzanthracene [Chemical/Ingredient]
Synonym: 9,10-dimethyl-1,2-benzanthracene (DMBA)
Synonym: Benz(a)anthracene, 7,12-dimethyl-
Synonym: DIMETHYLBENZANTHRACENE 07 12
Tree Number: T6.4.3.2.3
database_cross_reference: CHV:0000000523
database_cross_reference: CSP:5000-0031
database_cross_reference: MSH:D015127
database_cross_reference: NCI:C197
database_cross_reference: NCI_DCP:00008
database_cross_reference: NCI_DTP:NSC0408823
database_cross_reference: NDFRT:N0000167352

Benzocycloheptenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00001582
PMOID: PMO:00016897
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Benzocycloheptene
Synonym: Benzocycloheptene (substance)
Synonym: Benzocycloheptenes [Chemical/Ingredient]
Synonym: benzocycloheptene
Tree Number: T6.4.3.3
database_cross_reference: AOD:0000019782
database_cross_reference: MSH:D001567
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008139
database_cross_reference: SNOMEDCT_US:438934001

Dibenzocycloheptenes
type: Class
subclass of: Benzocycloheptenes
MCID: MC00003841
PMOID: PMO:00016898
Subclass_of: Benzocycloheptenes
Synonym: Dibenzocycloheptenes [Chemical/Ingredient]
Tree Number: T6.4.3.3.1
database_cross_reference: MSH:D003986
database_cross_reference: NDFRT:N0000007964

Cyproheptadine
type: Class
subclass of: Piperidines
MCID: MC00003440
PMOID: PMO:00016901
Subclass_of: Piperidines
Synonym: 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine
Synonym: 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine
Synonym: 4-(5-Dibenzo(a,D)cyclohepten-5-ylidine)-1-methylpiperidine
Synonym: 4-(5H-Dibenzo(a,D)cyclohepten-5-ylidene)-1-methylpiperidine
Synonym: 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine
Synonym: 4-Dibenzo[a,D]cyclohepten-5-ylidene-1-methyl-piperidine
Synonym: 5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
Synonym: 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
Synonym: Apeplus
Synonym: Apitup
Tree Number: T6.3.5.16.5
database_cross_reference: ATC:R06AX02
database_cross_reference: CHV:0000003537
database_cross_reference: CSP:0780-7203
database_cross_reference: DRUGBANK:DB00434
database_cross_reference: LNC:LP18932-1
database_cross_reference: LNC:MTHU006211
database_cross_reference: MEDCIN:340367
database_cross_reference: MMSL:d00790
database_cross_reference: MSH:D003533
database_cross_reference: MTHSPL:2YHB6175DO
database_cross_reference: NCI:C61695
database_cross_reference: NCI_FDA:2YHB6175DO
database_cross_reference: NCI_NCI-GLOSS:CDR0000340927
database_cross_reference: NDDF:004617
database_cross_reference: NDFRT:N0000005988
database_cross_reference: NDFRT:N0000147793
database_cross_reference: PDQ:CDR0000315774
database_cross_reference: RCD:x01Dw
database_cross_reference: RXNORM:3013
database_cross_reference: SNM:E-8849
database_cross_reference: SNMI:C-51030
database_cross_reference: SNOMEDCT_US:26462003
database_cross_reference: SNOMEDCT_US:372683000
database_cross_reference: USPMG:MTHU001634
database_cross_reference: VANDF:4019701

Fluorenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00005186
PMOID: PMO:00016906
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Fluorenes [Chemical/Ingredient]
Synonym: fluorene
Tree Number: T6.4.3.4
database_cross_reference: CSP:0779-4894
database_cross_reference: MSH:D005449
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008064

Tilorone
type: Class
subclass of: Fluorenes
MCID: MC00012861
PMOID: PMO:00016907
Subclass_of: Fluorenes
Synonym: 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-
Synonym: BISDEAEFLUORENONE
Synonym: Bis DEAE Fluorenone
Synonym: Bis-DEAE-Fluorenone
Synonym: TILORONE
Synonym: Tilorone (substance)
Synonym: Tilorone [Chemical/Ingredient]
Tree Number: T6.4.3.4.1
database_cross_reference: MSH:D013994
database_cross_reference: NCI:C73335
database_cross_reference: NCI_FDA:O6W7VEW6KS
database_cross_reference: NDFRT:N0000167341
database_cross_reference: SNM:E-7602
database_cross_reference: SNMI:C-79010
database_cross_reference: SNOMEDCT_US:30236005

Indenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00006794
PMOID: PMO:00016908
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Indenes [Chemical/Ingredient]
Tree Number: T6.4.3.5
database_cross_reference: LCH:U002404
database_cross_reference: LCH_NW:sh85064827
database_cross_reference: MSH:D007192
database_cross_reference: NDFRT:N0000007947

Dimethindene
type: Class
subclass of: Indenes
subclass of: Pyridines
MCID: MC00003955
PMOID: PMO:00016909
Subclass_of: Indenes
Subclass_of: Pyridines
Synonym: 1H-Indene-1,3(2h)-Dione, 5,6-Dimethyl-2-Nitro-, Ion(1-)
Synonym: 1H-Indene-2-Ethanamine, N,N-Dimethyl-3-(1-(2-Pyridinyl)Ethyl)-
Synonym: 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-
Synonym: 2-(1-(2-(2-(Dimethylamino)Ethyl)Inden-3-yl)Ethyl)Pyridine
Synonym: 3-(Alpha-(2'-Pyridyl)Ethyl)-2-(Beta-Dimethylaminoethyl)Indene
Synonym: DIMETHINDENE
Synonym: Dimethindene (product)
Synonym: Dimethindene (substance)
Synonym: Dimethindene [Chemical/Ingredient]
Synonym: Dimethpyrindene
Tree Number: T6.3.5.20.9
Tree Number: T6.4.3.5.1
database_cross_reference: ATC:D04AA13
database_cross_reference: ATC:R06AB03
database_cross_reference: CHV:0000003964
database_cross_reference: DRUGBANK:DB08801
database_cross_reference: MSH:D004115
database_cross_reference: MTHSPL:661FH77Z3P
database_cross_reference: NCI:C83675
database_cross_reference: NCI:C84130
database_cross_reference: NCI_FDA:661FH77Z3P
database_cross_reference: NDDF:004804
database_cross_reference: NDFRT:N0000167349
database_cross_reference: RCD:x01Dx
database_cross_reference: RXNORM:3449
database_cross_reference: SNM:E-8846
database_cross_reference: SNM:E-8848
database_cross_reference: SNMI:C-51660
database_cross_reference: SNOMEDCT_US:26122009
database_cross_reference: SNOMEDCT_US:387142004

Indans
type: Class
subclass of: Indenes
MCID: MC00006791
PMOID: PMO:00016910
Subclass_of: Indenes
Synonym: Indans [Chemical/Ingredient]
Tree Number: T6.4.3.5.2
database_cross_reference: MSH:D007189
database_cross_reference: NDFRT:N0000007944

Sulindac
type: Class
subclass of: Indenes
MCID: MC00012424
PMOID: PMO:00016914
Subclass_of: Indenes
Synonym: (Z)-5-Fluoro-2-methyl-1-((P-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
Synonym: (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Synonym: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-
Synonym: Apo-sulin Tab 150mg
Synonym: Apo-sulin Tab 200mg
Synonym: Clinoril Tab 150mg
Synonym: Clinoril Tab 200mg
Synonym: Nu-sulindac Tab 150mg
Synonym: Nu-sulindac Tab 200mg
Synonym: Penta-sulindac
Tree Number: T6.4.3.5.3
database_cross_reference: ATC:M01AB02
database_cross_reference: CCPSS:0032287
database_cross_reference: CHV:0000011881
database_cross_reference: DRUGBANK:DB00605
database_cross_reference: LCH:U004529
database_cross_reference: LCH_NW:sh85130323
database_cross_reference: LNC:LP18100-5
database_cross_reference: LNC:MTHU003386
database_cross_reference: MEDCIN:41964
database_cross_reference: MMSL:2100
database_cross_reference: MMSL:5535
database_cross_reference: MMSL:d00033
database_cross_reference: MSH:D013467
database_cross_reference: MTHSPL:184SNS8VUH
database_cross_reference: NCI:C850
database_cross_reference: NCI_DCP:00516
database_cross_reference: NCI_FDA:184SNS8VUH
database_cross_reference: NCI_NCI-GLOSS:CDR0000045372
database_cross_reference: NDDF:002386
database_cross_reference: NDFRT:N0000007042
database_cross_reference: NDFRT:N0000146307
database_cross_reference: PDQ:CDR0000041538
database_cross_reference: RCD:j2f..
database_cross_reference: RXNORM:10237
database_cross_reference: SNM:E-8825
database_cross_reference: SNMI:C-60440
database_cross_reference: SNOMEDCT_US:363623008
database_cross_reference: SNOMEDCT_US:387513000
database_cross_reference: SNOMEDCT_US:89505005
database_cross_reference: USPMG:MTHU000077
database_cross_reference: VANDF:4017957

Naphthacenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00008652
PMOID: PMO:00016915
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Benz(b)Anthracenes
Synonym: Naphthacenes [Chemical/Ingredient]
Synonym: Tetracenes
Tree Number: T6.4.3.6
database_cross_reference: MSH:D009279
database_cross_reference: NDFRT:N0000008200

Tetracyclines
type: Class
subclass of: Naphthacenes
MCID: MC00012648
PMOID: PMO:00016916
Subclass_of: Naphthacenes
Synonym: Tetracyclines [Chemical/Ingredient]
Tree Number: T6.4.3.6.1
database_cross_reference: MSH:D013754
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007948

Anthracyclines
type: Class
subclass of: Naphthacenes
subclass of: PMO:00020951
MCID: MC00098996
PMOID: PMO:00016926
Subclass_of: Aminoglycosides
Subclass_of: Naphthacenes
Synonym: Anthracyclines [Chemical/Ingredient]
Synonym: anthracycline
Synonym: anthracyclines
Tree Number: T6.4.3.6.2
Tree Number: T6.8.6.1.12
database_cross_reference: CHV:0000027648
database_cross_reference: LCH_NW:sh85005559
database_cross_reference: MSH:D018943
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007530

Naphthalenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00008655
PMOID: PMO:00016936
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Naphthalenes [Chemical/Ingredient]
Synonym: naphthalene
Synonym: naphthalenes
Tree Number: T6.4.3.7
database_cross_reference: AOD:0000019776
database_cross_reference: CSP:1991-2079
database_cross_reference: MSH:D009281
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007809

Adapalene
type: Class
subclass of: Naphthalenes
MCID: MC00064581
PMOID: PMO:00016937
Subclass_of: Naphthalenes
Synonym: 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid
Synonym: 6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid
Synonym: 6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic Acid
Synonym: ADAPALENE
Synonym: Adapalene (product)
Synonym: Adapalene (substance)
Synonym: Adapalene - chemical
Synonym: Adapalene - chemical (substance)
Synonym: Adapalene [Chemical/Ingredient]
Synonym: Adapaleno
Tree Number: T6.4.3.7.1
database_cross_reference: ATC:D10AD03
database_cross_reference: CHV:0000018073
database_cross_reference: DRUGBANK:DB00210
database_cross_reference: MEDCIN:75160
database_cross_reference: MMSL:173193
database_cross_reference: MMSL:4134
database_cross_reference: MSH:D000068816
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:1L4806J2QF
database_cross_reference: NCI:C28989
database_cross_reference: NCI_DCP:30033
database_cross_reference: NCI_FDA:1L4806J2QF
database_cross_reference: NDDF:005905
database_cross_reference: NDFRT:N0000006484
database_cross_reference: NDFRT:N0000148452
database_cross_reference: RCD:m6D..
database_cross_reference: RXNORM:60223
database_cross_reference: SNOMEDCT_US:108903004
database_cross_reference: SNOMEDCT_US:332377001
database_cross_reference: SNOMEDCT_US:386934008
database_cross_reference: SNOMEDCT_US:391719005
database_cross_reference: USPMG:MTHU003044
database_cross_reference: VANDF:4020981

Cinacalcet Hydrochloride
type: Class
subclass of: Naphthalenes
MCID: MC00423267
PMOID: PMO:00016938
Subclass_of: Naphthalenes
Synonym: 1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride
Synonym: Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride
Synonym: CINACALCET HYDROCHLORIDE
Synonym: Cinacalcet Hydrochloride [Chemical/Ingredient]
Synonym: Cinacalcet hydrochloride
Synonym: Cinacalcet hydrochloride (substance)
Synonym: Hydrochloride, Cinacalcet
Synonym: cinacalcet HCl
Synonym: cinacalcet hydrochloride
Synonym: cinacalcet hydrochloride (medication)
Tree Number: T6.4.3.7.2
database_cross_reference: MEDCIN:258978
database_cross_reference: MMSL:18133
database_cross_reference: MSH:D000069449
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:1K860WSG25
database_cross_reference: NCI:C47450
database_cross_reference: NCI_FDA:1K860WSG25
database_cross_reference: NDDF:008596
database_cross_reference: NDFRT:N0000191947
database_cross_reference: RXNORM:384379
database_cross_reference: SNOMEDCT_US:426512007
database_cross_reference: USPMG:MTHU001442

Acenaphthenes
type: Class
subclass of: Naphthalenes
MCID: MC00000163
PMOID: PMO:00016939
Subclass_of: Naphthalenes
Synonym: Acenaphthenes [Chemical/Ingredient]
Tree Number: T6.4.3.7.3
database_cross_reference: MSH:D000073
database_cross_reference: NDFRT:N0000167363

Bunaftine
type: Class
subclass of: Naphthalenes
MCID: MC00002010
PMOID: PMO:00016940
Subclass_of: Naphthalenes
Synonym: 1-Naphthalenecarboxamide, N-butyl-N-(2-(diethylamino)ethyl)-
Synonym: BUNAFTINE
Synonym: Bunaftide
Synonym: Bunaftine [Chemical/Ingredient]
Synonym: Bunaphtide
Synonym: Bunaphtine
Synonym: bunaftine
Tree Number: T6.4.3.7.4
database_cross_reference: ATC:C01BD03
database_cross_reference: MSH:D002035
database_cross_reference: NCI:C72578
database_cross_reference: NCI_FDA:GH09PRQ3FU
database_cross_reference: NDFRT:N0000167382

Dansyl Compounds
type: Class
subclass of: Naphthalenes
subclass of: Sulfones
MCID: MC00003539
PMOID: PMO:00016941
Subclass_of: Naphthalenes
Subclass_of: Sulfones
Synonym: Compounds, Dansyl
Synonym: Compounds, Dimethylaminonaphthalenesulfonyl
Synonym: DANSYL CPDS
Synonym: DIMETHYLAMINONAPHTHALENESULFONYL CPDS
Synonym: Dansyl Compounds [Chemical/Ingredient]
Synonym: Dimethylaminonaphthalenesulfonyl Compounds
Tree Number: T6.2.32.8.1
Tree Number: T6.4.3.7.5
database_cross_reference: MSH:D003619
database_cross_reference: NDFRT:N0000167380

Lovastatin
type: Class
subclass of: Naphthalenes
MCID: MC00007680
PMOID: PMO:00016942
Subclass_of: Naphthalenes
Synonym: (1S,3R,7S,8S,8AR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate
Synonym: (2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester
Synonym: 2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
Synonym: 6 Methylcompactin
Synonym: 6-Methylcompactin
Synonym: 6-alpha-methylcompactin
Synonym: 6alpha-Methylcompactin
Synonym: 6α-methylcompactin
Synonym: Act Lovastatin
Synonym: Apo-lovastatin - Tab 20mg
Tree Number: T6.4.3.7.6
database_cross_reference: ATC:C10AA02
database_cross_reference: CHV:0000007547
database_cross_reference: CSP:1991-4266
database_cross_reference: DRUGBANK:DB00227
database_cross_reference: LNC:LP171620-0
database_cross_reference: MEDCIN:41868
database_cross_reference: MMSL:42628
database_cross_reference: MMSL:4998
database_cross_reference: MMSL:d00280
database_cross_reference: MSH:D008148
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9LHU78OQFD
database_cross_reference: NCI:C620
database_cross_reference: NCI_DCP:30571
database_cross_reference: NCI_DTP:NSC0633781
database_cross_reference: NCI_FDA:9LHU78OQFD
database_cross_reference: NCI_NCI-GLOSS:CDR0000549703
database_cross_reference: NDDF:002063
database_cross_reference: NDFRT:N0000007106
database_cross_reference: NDFRT:N0000147602
database_cross_reference: PDQ:CDR0000041658
database_cross_reference: RXNORM:6472
database_cross_reference: SNMI:C-80810
database_cross_reference: SNOMEDCT_US:386024001
database_cross_reference: SNOMEDCT_US:74205000
database_cross_reference: SNOMEDCT_US:96303004
database_cross_reference: USPMG:MTHU001005
database_cross_reference: VANDF:4019482

Ezetimibe, Simvastatin Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00533962
PMOID: PMO:00016944
Subclass_of: Drug Combinations
Synonym: Butanoic Acid, 2,2-Dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl Ester, Mixture with (3R,4S)-1-(4-Fluorophenyl)-3-((3S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-2-azetidinone
Synonym: Combination, Ezetimibe-Simvastatin
Synonym: Combination, Ezetimibe-Simvastatin Drug
Synonym: Drug Combination, Ezetimibe-Simvastatin
Synonym: EZETIMIBE/SIMVASTATIN
Synonym: Ezetimibe + Simvastatin
Synonym: Ezetimibe + simvastatin
Synonym: Ezetimibe + simvastatin (product)
Synonym: Ezetimibe Simvastatin Combination
Synonym: Ezetimibe Simvastatin Drug Combination
Tree Number: T6.15.3.14
database_cross_reference: ATC:C10BA02
database_cross_reference: DRUGBANK:DB00641
database_cross_reference: DRUGBANK:DB00973
database_cross_reference: MEDCIN:259661
database_cross_reference: MMSL:d05348
database_cross_reference: MSH:D000069499
database_cross_reference: NCI:C123926
database_cross_reference: NDFRT:N0000022372
database_cross_reference: NDFRT:N0000191956
database_cross_reference: RXNORM:484211
database_cross_reference: SNOMEDCT_US:414175005
database_cross_reference: VANDF:4024368

Naphthaleneacetic Acids
type: Class
subclass of: Naphthalenes
MCID: MC00008654
PMOID: PMO:00016945
Subclass_of: Naphthalenes
Synonym: Acids, Naphthaleneacetic
Synonym: Naphthaleneacetic Acids [Chemical/Ingredient]
Synonym: Naphthaleneacetic acid
Tree Number: T6.4.3.7.7
database_cross_reference: LCH:U003118
database_cross_reference: LCH_NW:sh85089711
database_cross_reference: MSH:D009280
database_cross_reference: NDFRT:N0000007808

Naphthalenesulfonates
type: Class
subclass of: Naphthalenes
MCID: MC00008656
PMOID: PMO:00016947
Subclass_of: Naphthalenes
Synonym: Naphthalenesulfonates [Chemical/Ingredient]
Tree Number: T6.4.3.7.8
database_cross_reference: MSH:D009282
database_cross_reference: NDFRT:N0000007810

Naphthols
type: Class
subclass of: Naphthalenes
MCID: MC00008658
PMOID: PMO:00016950
Subclass_of: Naphthalenes
Synonym: Hydroxynaphthalenes
Synonym: Naphthol
Synonym: Naphthol (substance)
Synonym: Naphthol, NOS
Synonym: Naphthols [Chemical/Ingredient]
Synonym: naphthol
Tree Number: T6.4.3.7.9
database_cross_reference: CSP:0777-3317
database_cross_reference: LNC:LP18111-2
database_cross_reference: LNC:MTHU003393
database_cross_reference: MSH:D009284
database_cross_reference: NDFRT:N0000008204
database_cross_reference: SNM:E-5552
database_cross_reference: SNMI:C-21140
database_cross_reference: SNOMEDCT_US:58674002

Naphthoquinones
type: Class
subclass of: Naphthalenes
subclass of: Quinones
MCID: MC00008659
PMOID: PMO:00016951
Subclass_of: Naphthalenes
Subclass_of: Quinones
Synonym: Naphthalenediones
Synonym: Naphthoquinone
Synonym: Naphthoquinone (substance)
Synonym: Naphthoquinones [Chemical/Ingredient]
Synonym: naphthoquinone
Synonym: naphthoquinones
Tree Number: T6.2.30.2
Tree Number: T6.4.3.7.10
database_cross_reference: CHV:0000008482
database_cross_reference: CSP:1992-7925
database_cross_reference: LCH:U003119
database_cross_reference: LCH_NW:sh85089713
database_cross_reference: MSH:D009285
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007814
database_cross_reference: SNOMEDCT_US:406761003

Vitamin K 1
type: Class
subclass of: Naphthoquinones
MCID: MC00010194
PMOID: PMO:00016953
Subclass_of: Naphthoquinones
Synonym: 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, (R-(R*,R*-(E)))-
Synonym: 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
Synonym: 2-Methyl-3-[(2e)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone
Synonym: 2-Methyl-3-phytyl-1,4-naphthochinon
Synonym: 2-Methyl-3-phytyl-1,4-naphthoquinone
Synonym: 3-Phytylmenadione
Synonym: Adult Infuvite Multiple Vitamins
Synonym: Aqua-Mephyton
Synonym: Fitomenadiona
Synonym: Infuvite Adult Multiple Vitamins
Tree Number: T6.2.30.2.1
database_cross_reference: AOD:0000028223
database_cross_reference: ATC:B02BA01
database_cross_reference: CHV:0000009721
database_cross_reference: CSP:3147-8784
database_cross_reference: DRUGBANK:DB01022
database_cross_reference: LNC:LP17945-4
database_cross_reference: LNC:MTHU024798
database_cross_reference: MEDCIN:41287
database_cross_reference: MEDCIN:41306
database_cross_reference: MMSL:1433
database_cross_reference: MMSL:15677
database_cross_reference: MMSL:42273
database_cross_reference: MMSL:5298
database_cross_reference: MMSL:d03135
database_cross_reference: MSH:D010837
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:A034SE7857
database_cross_reference: NCI:C29365
database_cross_reference: NCI_CRCH:C29365
database_cross_reference: NCI_FDA:A034SE7857
database_cross_reference: NDDF:001038
database_cross_reference: NDFRT:N0000006032
database_cross_reference: NDFRT:N0000146136
database_cross_reference: RCD:ir2..
database_cross_reference: RXNORM:8308
database_cross_reference: SNM:E-8782
database_cross_reference: SNM:F-16190
database_cross_reference: SNMI:C-A5320
database_cross_reference: SNMI:F-BB190
database_cross_reference: SNOMEDCT_US:63136007
database_cross_reference: SNOMEDCT_US:66656000
database_cross_reference: VANDF:4017772

Vitamin K 2
type: Class
subclass of: Naphthoquinones
MCID: MC00043731
PMOID: PMO:00016954
Subclass_of: Naphthoquinones
Synonym: Menaquinone
Synonym: Menaquinones
Synonym: VITAMIN K A 02
Synonym: Vitamin K 2 [Chemical/Ingredient]
Synonym: Vitamin K Quinone
Synonym: Vitamin K2
Synonym: Vitamin K2 (substance)
Synonym: Vitamin K>2<
Tree Number: T6.2.30.2.2
database_cross_reference: AOD:0000028222
database_cross_reference: CHV:0000015971
database_cross_reference: CSP:3147-8784
database_cross_reference: LCH_NW:sh2006004121
database_cross_reference: MSH:D024482
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C68319
database_cross_reference: NCI_CRCH:C68319
database_cross_reference: NDFRT:N0000167381
database_cross_reference: RXNORM:42781
database_cross_reference: SNM:F-16200
database_cross_reference: SNMI:F-BB1A0
database_cross_reference: SNOMEDCT_US:22606007

Vitamin K 3
type: Class
subclass of: Naphthoquinones
MCID: MC00008030
PMOID: PMO:00016955
Subclass_of: Naphthoquinones
Synonym: 2-Methyl-1,4-Naphthalenedione
Synonym: 2-Methyl-1,4-naphthalenedione
Synonym: 2-Methyl-1,4-naphthochinon
Synonym: 2-Methyl-1,4-naphthoquinone
Synonym: 2-Methylnaphthoquinone
Synonym: MENADIONE
Synonym: Menadione
Synonym: Menadione (substance)
Synonym: Menadione preparation
Synonym: Menadione preparation (product)
Tree Number: T6.2.30.2.3
database_cross_reference: AOD:0000028221
database_cross_reference: ATC:B02BA02
database_cross_reference: CHV:0000007923
database_cross_reference: CSP:3147-9150
database_cross_reference: DRUGBANK:DB00170
database_cross_reference: LNC:LP15951-4
database_cross_reference: LNC:MTHU014694
database_cross_reference: MEDCIN:199144
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D024483
database_cross_reference: MTHSPL:723JX6CXY5
database_cross_reference: NCI:C66086
database_cross_reference: NCI_FDA:723JX6CXY5
database_cross_reference: NDDF:001039
database_cross_reference: NDFRT:N0000005058
database_cross_reference: NDFRT:N0000147378
database_cross_reference: RXNORM:6728
database_cross_reference: SNM:E-8776
database_cross_reference: SNMI:C-A5310
database_cross_reference: SNMI:F-BB1B0
database_cross_reference: SNOMEDCT_US:412244007
database_cross_reference: SNOMEDCT_US:69169004
database_cross_reference: SNOMEDCT_US:69576000
database_cross_reference: VANDF:4019127

Naphthylvinylpyridine
type: Class
subclass of: Naphthalenes
subclass of: Pyridines
MCID: MC00008660
PMOID: PMO:00016956
Subclass_of: Naphthalenes
Subclass_of: Pyridines
Synonym: Naphthylvinylpyridine [Chemical/Ingredient]
Synonym: Pyridine, 4-(2-(1-naphthalenyl)ethenyl)-
Tree Number: T6.3.5.20.14
Tree Number: T6.4.3.7.11
database_cross_reference: MSH:D009286
database_cross_reference: NDFRT:N0000167378

Tetrahydronaphthalenes
type: Class
subclass of: Naphthalenes
MCID: MC00012659
PMOID: PMO:00016957
Subclass_of: Naphthalenes
Synonym: Tetrahydronaphthalenes [Chemical/Ingredient]
Synonym: Tetralins
Tree Number: T6.4.3.7.14
database_cross_reference: MSH:D013764
database_cross_reference: NDFRT:N0000007952

Etoposide
type: Class
subclass of: PMO:00020974
MCID: MC00004827
PMOID: PMO:00016958
Subclass_of: Glucosides
Synonym: (-)-Etoposide
Synonym: (−)-etoposide
Synonym: 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)
Synonym: 4'-Demethylepipodophyllotoxin 9-[4,6-O-ethylidene-beta-D-glucopyranoside
Synonym: 4'-Demethylepipodophyllotoxin 9-[4,6-O-ethylidene-beta-D-glucopyranoside]
Synonym: 4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside
Synonym: 4-demethylepipodophyllotoxin β-D-ethylideneglucoside
Synonym: 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one
Synonym: 9-[(4,6-O-Ethylidene-beta-D-glucopyranosyl]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Synonym: 9-[(4,6-O-Ethylidene-beta-D-glucopyranosyl]oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Tree Number: T6.8.6.7.6
database_cross_reference: ATC:L01CB01
database_cross_reference: CHV:0000004724
database_cross_reference: CSP:1991-5300
database_cross_reference: DRUGBANK:DB00773
database_cross_reference: LCH:U001686
database_cross_reference: LCH_NW:sh85045458
database_cross_reference: MEDCIN:48428
database_cross_reference: MMSL:4209
database_cross_reference: MMSL:4709
database_cross_reference: MMSL:d00230
database_cross_reference: MSH:D005047
database_cross_reference: MTHSPL:6PLQ3CP4P3
database_cross_reference: NCI:C491
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_DCP:30262
database_cross_reference: NCI_DTP:NSC0141540
database_cross_reference: NCI_FDA:6PLQ3CP4P3
database_cross_reference: NCI_NCI-GLOSS:CDR0000045189
database_cross_reference: NDDF:002674
database_cross_reference: NDFRT:N0000006798
database_cross_reference: NDFRT:N0000146478
database_cross_reference: PDQ:CDR0000039207
database_cross_reference: RCD:h41..
database_cross_reference: RXNORM:4179
database_cross_reference: SNMI:C-780D0
database_cross_reference: SNOMEDCT_US:387316009
database_cross_reference: SNOMEDCT_US:56928005
database_cross_reference: USPMG:MTHU000519
database_cross_reference: VANDF:4018141

1-Naphthylisothiocyanate
type: Class
subclass of: Naphthalenes
subclass of: Isothiocyanates
MCID: MC00000010
PMOID: PMO:00016962
Subclass_of: Isothiocyanates
Subclass_of: Naphthalenes
Synonym: 1 Naphthylisothiocyanate
Synonym: 1-Naphthylisothiocyanate [Chemical/Ingredient]
Synonym: NAPHTHYLISOTHIOCYANATE 01
Synonym: Naphthalene, 1-isothiocyanato-
Synonym: alpha Naphthylisothiocyanate
Synonym: alpha-Naphthylisothiocyanate
Tree Number: T6.2.32.26.2
Tree Number: T6.2.37.2.2
Tree Number: T6.4.3.7.17
database_cross_reference: MSH:D015058
database_cross_reference: NDFRT:N0000167379

Pravastatin
type: Class
subclass of: Naphthalenes
MCID: MC00043317
PMOID: PMO:00016963
Subclass_of: Naphthalenes
Synonym: (+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid
Synonym: 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha))-
Synonym: Ach-pravastatin
Synonym: Act Pravastatin
Synonym: Auro-pravastatin
Synonym: Ava-pravastatin
Synonym: Bio Pravastatin
Synonym: Bio-pravastatin
Synonym: Dom-pravastatin
Synonym: Eptastatin
Tree Number: T6.4.3.7.19
database_cross_reference: ATC:C10AA03
database_cross_reference: CHV:0000015639
database_cross_reference: CSP:0658-5374
database_cross_reference: CSP:1991-2079
database_cross_reference: DRUGBANK:DB00175
database_cross_reference: LCH_NW:sh2002000834
database_cross_reference: LNC:LP171630-9
database_cross_reference: MEDCIN:42575
database_cross_reference: MMSL:d00348
database_cross_reference: MSH:D017035
database_cross_reference: MTHSPL:KXO2KT9N0G
database_cross_reference: NCI:C62070
database_cross_reference: NCI_DCP:02539
database_cross_reference: NCI_FDA:KXO2KT9N0G
database_cross_reference: NCI_NCI-GLOSS:CDR0000430875
database_cross_reference: NDDF:003606
database_cross_reference: NDFRT:N0000007054
database_cross_reference: NDFRT:N0000148255
database_cross_reference: PDQ:CDR0000424450
database_cross_reference: RCD:x01R3
database_cross_reference: RXNORM:42463
database_cross_reference: SNMI:C-80820
database_cross_reference: SNOMEDCT_US:373566006
database_cross_reference: SNOMEDCT_US:96305006
database_cross_reference: USPMG:MTHU001006
database_cross_reference: VANDF:4020548

Phenanthrenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00009996
PMOID: PMO:00016964
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Phenanthrene derivative
Synonym: Phenanthrene derivative (product)
Synonym: Phenanthrene derivative (substance)
Synonym: Phenanthrenes [Chemical/Ingredient]
Tree Number: T6.4.3.8
database_cross_reference: MSH:D010616
database_cross_reference: NDFRT:N0000007517
database_cross_reference: SNMI:C-60620
database_cross_reference: SNOMEDCT_US:15375005
database_cross_reference: SNOMEDCT_US:373704008

Chrysenes
type: Class
subclass of: Phenanthrenes
MCID: MC00002882
PMOID: PMO:00016965
Subclass_of: Phenanthrenes
Synonym: 1,2,5,6-Dibenzonaphthalene
Synonym: 1,2-Benzophenanthrene
Synonym: 1,2-Benzphenanthrene
Synonym: Benz(a)phenanthrene
Synonym: Benzo(a)phenanthrene
Synonym: CHRYSENE
Synonym: Chrysene
Synonym: Chrysenes [Chemical/Ingredient]
Synonym: chrysene
Tree Number: T6.4.3.8.1
database_cross_reference: CSP:0779-6054
database_cross_reference: MSH:D002911
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C373
database_cross_reference: NCI_FDA:084HCM49PT
database_cross_reference: NDFRT:N0000167354

Aristolochic Acids
type: Class
subclass of: Phenanthrenes
subclass of: Nitro Compounds
MCID: MC00377799
PMOID: PMO:00016966
Subclass_of: Nitro Compounds
Subclass_of: Phenanthrenes
Synonym: Aristolochic Acids [Chemical/Ingredient]
Tree Number: T6.2.25.9
Tree Number: T6.4.3.8.3
database_cross_reference: MSH:D034341
database_cross_reference: NDFRT:N0000167356

Diterpenes, Abietane
type: Class
subclass of: Phenanthrenes
MCID: MC00421760
PMOID: PMO:00016967
Subclass_of: Phenanthrenes
Synonym: Abietane Diterpenes
Synonym: Abietanes
Synonym: Diterpenes, Abietane [Chemical/Ingredient]
Tree Number: T6.4.3.8.4
database_cross_reference: MSH:D045784
database_cross_reference: NDFRT:N0000167355

Pyrenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00010988
PMOID: PMO:00016968
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Pyrenes [Chemical/Ingredient]
Synonym: pyrene
Synonym: pyrenes
Tree Number: T6.4.3.9
database_cross_reference: AOD:0000019792
database_cross_reference: CHV:0000010447
database_cross_reference: CSP:0779-6464
database_cross_reference: MSH:D011721
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167357

Benzopyrenes
type: Class
subclass of: Pyrenes
MCID: MC00001594
PMOID: PMO:00016969
Subclass_of: Pyrenes
Synonym: Benzopyrene
Synonym: Benzopyrenes [Chemical/Ingredient]
Synonym: benzopyrene
Tree Number: T6.4.3.9.1
database_cross_reference: CHV:0000001798
database_cross_reference: CSP:0779-5835
database_cross_reference: LCH:U000542
database_cross_reference: MSH:D001580
database_cross_reference: NDFRT:N0000167358

Phenalenes
type: Class
subclass of: Polycyclic Aromatic Hydrocarbons
MCID: MC00421561
PMOID: PMO:00016973
Subclass_of: Polycyclic Aromatic Hydrocarbons
Synonym: Phenalenes [Chemical/Ingredient]
Tree Number: T6.4.3.10
database_cross_reference: MSH:D043803
database_cross_reference: NDFRT:N0000167373

Spiro Compounds
type: Class
subclass of: Hydrocarbons, Cyclic
subclass of: Polycyclic Compounds
MCID: MC00012144
PMOID: PMO:00016974
Subclass_of: Hydrocarbons, Cyclic
Subclass_of: Polycyclic Compounds
Synonym: Compounds, Spiro
Synonym: SPIRO CPDS
Synonym: Spiro Compounds [Chemical/Ingredient]
Synonym: spiro compound
Tree Number: T6.2.17.2.4
Tree Number: T6.4.4
database_cross_reference: CSP:0779-7727
database_cross_reference: MSH:D013141
database_cross_reference: NDFRT:N0000007532

Buspirone
type: Class
subclass of: Spiro Compounds
subclass of: Piperazines
subclass of: Pyrimidines
MCID: MC00002037
PMOID: PMO:00016975
Subclass_of: Piperazines
Subclass_of: Pyrimidines
Subclass_of: Spiro Compounds
Synonym: 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione
Synonym: 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-
Synonym: Ansial
Synonym: Anxiron
Synonym: Apo-buspirone - Tab 10mg
Synonym: BUSPIRONE
Synonym: Buscalm
Synonym: Buspar Tab 10mg
Synonym: Buspiron
Synonym: Buspirona
Tree Number: T6.3.5.15.9
Tree Number: T6.3.5.21.6
Tree Number: T6.4.4.1
database_cross_reference: AOD:0000020800
database_cross_reference: ATC:N05BE01
database_cross_reference: CHV:0000002244
database_cross_reference: CSP:4000-0133
database_cross_reference: DRUGBANK:DB00490
database_cross_reference: LCH_NW:sh90002754
database_cross_reference: LNC:LP17859-7
database_cross_reference: LNC:MTHU024715
database_cross_reference: MEDCIN:41861
database_cross_reference: MMSL:d00182
database_cross_reference: MSH:D002065
database_cross_reference: MTHSPL:TK65WKS8HL
database_cross_reference: NCI:C62013
database_cross_reference: NCI_FDA:TK65WKS8HL
database_cross_reference: NCI_NCI-GLOSS:CDR0000302452
database_cross_reference: NDDF:004586
database_cross_reference: NDFRT:N0000007480
database_cross_reference: NDFRT:N0000147739
database_cross_reference: PSY:07165
database_cross_reference: RCD:x01BH
database_cross_reference: RXNORM:1827
database_cross_reference: SNMI:C-64210
database_cross_reference: SNOMEDCT_US:387523009
database_cross_reference: SNOMEDCT_US:91452003
database_cross_reference: USPMG:MTHU000699
database_cross_reference: VANDF:4019646

Fluorescamine
type: Class
subclass of: Spiro Compounds
MCID: MC00005187
PMOID: PMO:00016976
Subclass_of: Spiro Compounds
Synonym: Fluorescamine [Chemical/Ingredient]
Synonym: Spiro(furan-2(3H),1'(3'H)-isobenzofuran)-3,3'-dione, 4-phenyl-
Tree Number: T6.4.4.2
database_cross_reference: MSH:D005450
database_cross_reference: NDFRT:N0000167365

Fluoresceins
type: Class
subclass of: Spiro Compounds
MCID: MC00005188
PMOID: PMO:00016977
Subclass_of: Spiro Compounds
Synonym: Fluoresceins [Chemical/Ingredient]
Tree Number: T6.4.4.3
database_cross_reference: MSH:D005452
database_cross_reference: NDFRT:N0000008067

Eosine Yellowish-(YS)
type: Class
subclass of: Fluoresceins
MCID: MC00004566
PMOID: PMO:00016978
Subclass_of: Fluoresceins
Synonym: 11445 Red
Synonym: 1903 Yellow Pink
Synonym: 2',4',5',7'-Tetrabromofluorescein Disodium Salt
Synonym: ACID RED 87
Synonym: Acid Red 87
Synonym: C.I. Acid Red 87
Synonym: D & C RED #22
Synonym: D & C Red #22
Synonym: D and C red no.22
Synonym: D&C RED NO. 22
Tree Number: T6.4.4.3.1
database_cross_reference: ATC:D08AX02
database_cross_reference: CHV:0000004528
database_cross_reference: LCH:U001619
database_cross_reference: LCH_NW:sh85044241
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D004801
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:1678RKX8RT
database_cross_reference: MTHSPL:TDQ283MPCW
database_cross_reference: NCI:C71658
database_cross_reference: NCI_FDA:1678RKX8RT
database_cross_reference: NDDF:009250
database_cross_reference: NDDF:010155
database_cross_reference: NDFRT:N0000022860
database_cross_reference: NDFRT:N0000167369
database_cross_reference: RCD:X79IM
database_cross_reference: RXNORM:1310593
database_cross_reference: SNM:E-6286
database_cross_reference: SNOMEDCT_US:256012001
database_cross_reference: SNOMEDCT_US:411353000
database_cross_reference: VANDF:4020642

Erythrosine
type: Class
subclass of: Fluoresceins
PMOID: PMO:00016979
Subclass_of: Fluoresceins
Tree Number: T6.4.4.3.2

Eosine I Bluish
type: Class
subclass of: Fluoresceins
MCID: MC00010081
PMOID: PMO:00016980
Subclass_of: Fluoresceins
Synonym: Bluish, Eosine
Synonym: Bluish, Eosine I
Synonym: Eosin B
Synonym: Eosine B
Synonym: Eosine Bluish
Synonym: Eosine I Bluish [Chemical/Ingredient]
Synonym: Phloxin B
Synonym: Phloxin B (substance)
Synonym: Phloxin B stain
Synonym: Phloxin B stain (substance)
Tree Number: T6.4.4.3.3
database_cross_reference: MSH:D010697
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167371
database_cross_reference: SNMI:C-22922
database_cross_reference: SNOMEDCT_US:71957009

Rose Bengal
type: Class
subclass of: Fluoresceins
MCID: MC01077378
PMOID: PMO:00016981
Subclass_of: Fluoresceins
Synonym: 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein
Synonym: GloStrips
Synonym: Odan-rose
Synonym: Rose bengal
Synonym: RoseGlo
Tree Number: T6.4.4.3.4
database_cross_reference: DRUGBANK:DB11182

Fluorescein-5-isothiocyanate
type: Class
subclass of: Fluoresceins
subclass of: Isothiocyanates
MCID: MC00043211
PMOID: PMO:00016982
Subclass_of: Fluoresceins
Subclass_of: Isothiocyanates
Synonym: 5 Isothiocyanatofluorescein
Synonym: 5-Isothiocyanatofluorescein
Synonym: FITC
Synonym: FLUORESCEIN ISOTHIOCYANATE 05
Synonym: Fluorescein 5 isothiocyanate
Synonym: Fluorescein-5-isothiocyanate [Chemical/Ingredient]
Synonym: Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-5-isothiocyanato-
Synonym: fitc
Synonym: fluorescein-5-isothiocyanate (FITC)
Tree Number: T6.2.32.26.3
Tree Number: T6.2.37.2.3
Tree Number: T6.4.4.3.5
database_cross_reference: CHV:0000015501
database_cross_reference: MSH:D016650
database_cross_reference: NDFRT:N0000167372

Fluorescein
type: Class
subclass of: Fluoresceins
MCID: MC00026947
PMOID: PMO:00016983
Subclass_of: Fluoresceins
Synonym: 3',6'-dihydroxyfluoran
Synonym: 3,6-fluorandiol
Synonym: 9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenone
Synonym: 9-(o-carboxyphenyl)-6-hydroxy-3H-xanthen-3-one
Synonym: Bio Glo
Synonym: C.I. Solvent Yellow 94
Synonym: Diofluor Strips
Synonym: Dry Eye Test
Synonym: FLUORESCEIN
Synonym: Fluorescein (substance)
Tree Number: T6.4.4.3.6
database_cross_reference: ATC:S01JA01
database_cross_reference: CHV:0000014040
database_cross_reference: CSP:0396-3486
database_cross_reference: DRUGBANK:DB00693
database_cross_reference: LCH:U001825
database_cross_reference: LCH_NW:sh85049406
database_cross_reference: MMSL:20713
database_cross_reference: MMSL:80888
database_cross_reference: MMSL:d05815
database_cross_reference: MSH:D019793
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:TPY09G7XIR
database_cross_reference: NCI:C61766
database_cross_reference: NCI_FDA:TPY09G7XIR
database_cross_reference: NDDF:004884
database_cross_reference: NDFRT:N0000006902
database_cross_reference: NDFRT:N0000147851
database_cross_reference: RCD:X79Cb
database_cross_reference: RCD:x01Ga
database_cross_reference: RXNORM:25138
database_cross_reference: SNM:E-8104
database_cross_reference: SNMI:C-22A05
database_cross_reference: SNOMEDCT_US:350086004
database_cross_reference: SNOMEDCT_US:85596006
database_cross_reference: VANDF:4019760

Fluspirilene
type: Class
subclass of: Spiro Compounds
subclass of: Piperidines
MCID: MC00005221
PMOID: PMO:00016984
Subclass_of: Piperidines
Subclass_of: Spiro Compounds
Synonym: 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4,4-bis(4-fluorophenyl)butyl)-1-phenyl-
Synonym: Fluspirilene (product)
Synonym: Fluspirilene (substance)
Synonym: Fluspirilene [Chemical/Ingredient]
Synonym: Fluspirileno
Synonym: Fluspirilenum
Synonym: Spirodiflamine
Synonym: fluspirilene
Tree Number: T6.3.5.16.9
Tree Number: T6.4.4.4
database_cross_reference: ATC:N05AG01
database_cross_reference: DRUGBANK:DB04842
database_cross_reference: LNC:LP183644-6
database_cross_reference: LNC:MTHU047891
database_cross_reference: MSH:D005484
database_cross_reference: NDDF:003485
database_cross_reference: NDFRT:N0000167366
database_cross_reference: RCD:d54..
database_cross_reference: RXNORM:4507
database_cross_reference: SNOMEDCT_US:321692003
database_cross_reference: SNOMEDCT_US:419373008

Leucogenenol
type: Class
subclass of: Spiro Compounds
MCID: MC00007465
PMOID: PMO:00016985
Subclass_of: Spiro Compounds
Synonym: Leucogenenol [Chemical/Ingredient]
Tree Number: T6.4.4.5
database_cross_reference: MSH:D007932
database_cross_reference: NDFRT:N0000167364

Spiperone
type: Class
subclass of: Spiro Compounds
subclass of: Butyrophenones
MCID: MC00012139
PMOID: PMO:00016986
Subclass_of: Butyrophenones
Subclass_of: Spiro Compounds
Synonym: 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4-(4-fluorophenyl)-4-oxobutyl)-1-phenyl-
Synonym: SPIPERONE
Synonym: Spiperone (substance)
Synonym: Spiperone - chemical
Synonym: Spiperone - chemical (substance)
Synonym: Spiperone [Chemical/Ingredient]
Synonym: Spiroperidol
Synonym: Spiroperone
Tree Number: T6.2.20.5.5
Tree Number: T6.4.4.7
database_cross_reference: MSH:D013134
database_cross_reference: NCI:C66558
database_cross_reference: NCI_FDA:4X6E73CJ0Q
database_cross_reference: NDFRT:N0000167367
database_cross_reference: PSY:49313
database_cross_reference: PSY:49317
database_cross_reference: SNMI:C-63230
database_cross_reference: SNOMEDCT_US:363526006
database_cross_reference: SNOMEDCT_US:77222007

Hydrocarbons, Halogenated
type: Class
subclass of: Hydrocarbons
MCID: MC00006453
PMOID: PMO:00016987
Subclass_of: Hydrocarbons
Synonym: 208-209 HALOGENATED HYDROCARBONS
Synonym: HALOGENATED HYDROCARBONS
Synonym: Halocarbons
Synonym: Halogenated Hydrocarbon
Synonym: Halogenated Hydrocarbons
Synonym: Halogenated hydrocarbon
Synonym: Halogenated hydrocarbon (substance)
Synonym: Halogenated hydrocarbon, NOS
Synonym: Hydrocarbons, Halogenated [Chemical/Ingredient]
Synonym: Hydrocarbons.halogenated
Tree Number: T6.2.17.3
database_cross_reference: AOD:0000020079
database_cross_reference: CHV:0000006342
database_cross_reference: CSP:1374-3425
database_cross_reference: LCH:U005664
database_cross_reference: LCH_NW:sh85058504
database_cross_reference: LNC:LP18116-1
database_cross_reference: LNC:MTHU003406
database_cross_reference: MSH:D006846
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C554
database_cross_reference: NDFRT:N0000007977
database_cross_reference: RCD:Xa7Mv
database_cross_reference: SNM:E-5460
database_cross_reference: SNM:U000133
database_cross_reference: SNMI:C-20800
database_cross_reference: SNOMEDCT_US:41105002

Halothane
type: Class
subclass of: Hydrocarbons, Halogenated
MCID: MC00005933
PMOID: PMO:00016988
Subclass_of: Hydrocarbons, Halogenated
Synonym: 1,1,1-Trifluoro-2-Chloro-2-Bromoethane
Synonym: 1,1,1-Trifluoro-2-bromo-2-chloroethane
Synonym: 1,1,1-Trifluoro-2-chloro-2-bromoethane
Synonym: 1-Bromo-1-chloro-2,2,2-trifluoroethane
Synonym: 2,2,2-Trifluoro-1-chloro-1-bromoethane
Synonym: 2-Bromo-2-Chloro-1,1,1-Trifluoroethane
Synonym: Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-
Synonym: Fluothane Anesthetic
Synonym: Fluothane Liq Inh 1000mg/gm
Synonym: HALOTHANE
Tree Number: T6.2.17.3.1
database_cross_reference: AOD:0000020082
database_cross_reference: ATC:N01AB01
database_cross_reference: CHV:0000005783
database_cross_reference: CSP:1371-7455
database_cross_reference: DRUGBANK:DB01159
database_cross_reference: LCH:U002073
database_cross_reference: LCH_NW:sh85058513
database_cross_reference: LNC:LP18067-6
database_cross_reference: LNC:MTHU003330
database_cross_reference: MMSL:4820
database_cross_reference: MMSL:601
database_cross_reference: MMSL:d00251
database_cross_reference: MSH:D006221
database_cross_reference: NCI:C47554
database_cross_reference: NCI_FDA:UQT9G45D1P
database_cross_reference: NDDF:001394
database_cross_reference: NDFRT:N0000006050
database_cross_reference: NDFRT:N0000146821
database_cross_reference: RCD:o24..
database_cross_reference: RXNORM:5095
database_cross_reference: SNM:E-7055
database_cross_reference: SNMI:C-6A112
database_cross_reference: SNOMEDCT_US:387351001
database_cross_reference: SNOMEDCT_US:63682003
database_cross_reference: VANDF:4018499

Hydrocarbons, Brominated
type: Class
subclass of: Hydrocarbons, Halogenated
MCID: MC00006449
PMOID: PMO:00016989
Subclass_of: Hydrocarbons, Halogenated
Synonym: Brominated Hydrocarbons
Synonym: Brominated hydrocarbon
Synonym: Brominated hydrocarbon (substance)
Synonym: Hydrocarbons, Brominated [Chemical/Ingredient]
Tree Number: T6.2.17.3.2
database_cross_reference: MSH:D006842
database_cross_reference: NDFRT:N0000008230
database_cross_reference: RCD:Xa7PE
database_cross_reference: SNOMEDCT_US:300051009

Hydrocarbons, Chlorinated
type: Class
subclass of: Hydrocarbons, Halogenated
MCID: MC00006450
PMOID: PMO:00016993
Subclass_of: Hydrocarbons, Halogenated
Synonym: Chlorinated Hydrocarbons
Synonym: Chlorinated hydrocarbon
Synonym: Chlorinated hydrocarbon (substance)
Synonym: Chlorinated hydrocarbon, NOS
Synonym: Chlorine Compounds, Organic
Synonym: Chlorohydrocarbons
Synonym: Compounds, Organic Chlorine
Synonym: Compounds, Organochlorine
Synonym: Hydrocarbons, Chlorinated [Chemical/Ingredient]
Synonym: Hydrocarbons.chlorinated
Tree Number: T6.2.17.3.3
database_cross_reference: AOD:0000020084
database_cross_reference: CHV:0000006341
database_cross_reference: CSP:1374-3662
database_cross_reference: LCH:U005368
database_cross_reference: LCH:U005661
database_cross_reference: LCH_NW:sh85024567
database_cross_reference: LNC:LP14503-4
database_cross_reference: LNC:MTHU003714
database_cross_reference: MSH:D006843
database_cross_reference: NCI:C1443
database_cross_reference: NDFRT:N0000007975
database_cross_reference: RCD:Xa7PF
database_cross_reference: SNM:E-5470
database_cross_reference: SNMI:C-20801
database_cross_reference: SNOMEDCT_US:56181003

Hydrocarbons, Fluorinated
type: Class
subclass of: Hydrocarbons, Halogenated
MCID: MC00006452
PMOID: PMO:00017021
Subclass_of: Hydrocarbons, Halogenated
Synonym: Fluorinated Hydrocarbons
Synonym: Fluorinated hydrocarbon
Synonym: Fluorinated hydrocarbon (substance)
Synonym: Fluorinated hydrocarbon, NOS
Synonym: Fluorohydrocarbons
Synonym: Hydrocarbons, Fluorinated [Chemical/Ingredient]
Synonym: fluorinated hydrocarbons
Synonym: fluorohydrocarbon
Tree Number: T6.2.17.3.4
database_cross_reference: AOD:0000028864
database_cross_reference: CSP:1374-3899
database_cross_reference: LCH:U005663
database_cross_reference: LCH_NW:sh85049439
database_cross_reference: MSH:D006845
database_cross_reference: NDFRT:N0000008231
database_cross_reference: RCD:Xa7PW
database_cross_reference: SNM:E-5508
database_cross_reference: SNMI:C-20802
database_cross_reference: SNOMEDCT_US:42850000

Hydrocarbons, Iodinated
type: Class
subclass of: Hydrocarbons, Halogenated
MCID: MC00006454
PMOID: PMO:00017023
Subclass_of: Hydrocarbons, Halogenated
Synonym: Hydrocarbons, Iodinated [Chemical/Ingredient]
Synonym: Iodinated Hydrocarbons
Synonym: Iodinated hydrocarbon
Synonym: Iodinated hydrocarbon (substance)
Tree Number: T6.2.17.3.5
database_cross_reference: MSH:D006847
database_cross_reference: NDFRT:N0000008232
database_cross_reference: RCD:Xa7PL
database_cross_reference: SNOMEDCT_US:300053007

Mustard Compounds
type: Class
subclass of: Hydrocarbons, Halogenated
PMOID: PMO:00017024
Subclass_of: Hydrocarbons, Halogenated
Tree Number: T6.2.17.3.6

Peptichemio
type: Class
subclass of: PMO:00021376
MCID: MC00009862
PMOID: PMO:00017034
Subclass_of: Oligopeptides
Synonym: Multialchilpeptide
Synonym: PTC
Synonym: Peptichemio [Chemical/Ingredient]
Synonym: peptichemio
Synonym: peptide bound m-L-sarcolysin
Tree Number: T6.10.2.13.16
database_cross_reference: MSH:D010440
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C734
database_cross_reference: NDFRT:N0000170305
database_cross_reference: PDQ:CDR0000039541

Phosphoramide Mustards
type: Class
subclass of: Phosphoramides
PMOID: PMO:00017035
Subclass_of: Phosphoramides
Tree Number: T6.2.29.7.2

Ifosfamide
type: Class
subclass of: Oxazines
MCID: MC00006682
PMOID: PMO:00017037
Subclass_of: Oxazines
Synonym: 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine
Synonym: 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
Synonym: 3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Synonym: 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide
Synonym: Celofos
Synonym: Cuantil
Synonym: IFF
Synonym: IFO
Synonym: IFOSFAMIDE
Synonym: IFX
Tree Number: T6.3.5.13.2
database_cross_reference: ATC:L01AA06
database_cross_reference: CHV:0000006537
database_cross_reference: CSP:4000-0210
database_cross_reference: DRUGBANK:DB01181
database_cross_reference: LNC:LP65832-5
database_cross_reference: LNC:LP65841-6
database_cross_reference: MEDCIN:48462
database_cross_reference: MMSL:44391
database_cross_reference: MMSL:4867
database_cross_reference: MMSL:d00257
database_cross_reference: MSH:D007069
database_cross_reference: MTH:U002000
database_cross_reference: MTHSPL:UM20QQM95Y
database_cross_reference: NCI:C564
database_cross_reference: NCI_DTP:NSC0109724
database_cross_reference: NCI_FDA:UM20QQM95Y
database_cross_reference: NCI_NCI-GLOSS:CDR0000045267
database_cross_reference: NDDF:002642
database_cross_reference: NDFRT:N0000007045
database_cross_reference: NDFRT:N0000147596
database_cross_reference: PDQ:CDR0000040024
database_cross_reference: RCD:h17..
database_cross_reference: RXNORM:5657
database_cross_reference: SNOMEDCT_US:108757000
database_cross_reference: SNOMEDCT_US:386904003
database_cross_reference: VANDF:4019476

Trihalomethanes
type: Class
subclass of: Hydrocarbons, Halogenated
MCID: MC00013092
PMOID: PMO:00017040
Subclass_of: Hydrocarbons, Halogenated
Synonym: Trihalomethane
Synonym: Trihalomethanes [Chemical/Ingredient]
Synonym: trihalomethane
Synonym: trihalomethanes
Tree Number: T6.2.17.3.7
database_cross_reference: CHV:0000012564
database_cross_reference: LCH_NW:sh85137529
database_cross_reference: MSH:D022882
database_cross_reference: NDFRT:N0000166315

Paraffin
type: Class
subclass of: Hydrocarbons
MCID: MC00009698
PMOID: PMO:00017041
Subclass_of: Hydrocarbons
Synonym: Hard paraffin
Synonym: Hard paraffin (product)
Synonym: PARAFFIN
Synonym: PARAFFIN HYDROCARBONS
Synonym: PARAFFIN WAX
Synonym: PARAFFIN WAX [VA Product]
Synonym: Paraffin (substance)
Synonym: Paraffin (substance) [Ambiguous]
Synonym: Paraffin Wax
Synonym: Paraffin [Chemical/Ingredient]
Tree Number: T6.2.17.4
database_cross_reference: CHV:0000009259
database_cross_reference: LCH:U003469
database_cross_reference: LCH_NW:sh90001517
database_cross_reference: MDDB:29059
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D010232
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:I9O0E3H2ZE
database_cross_reference: NCI:C727
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_FDA:I9O0E3H2ZE
database_cross_reference: NDDF:002449
database_cross_reference: NDFRT:N0000007431
database_cross_reference: NDFRT:N0000148173
database_cross_reference: NDFRT:N0000148174
database_cross_reference: NDFRT:N0000172011
database_cross_reference: RCD:X796W
database_cross_reference: RCD:XaD1O
database_cross_reference: RCD:x01Gq
database_cross_reference: RXNORM:7906
database_cross_reference: SNM:E-5427
database_cross_reference: SNMI:C-20240
database_cross_reference: SNOMEDCT_US:255667006
database_cross_reference: SNOMEDCT_US:311731000
database_cross_reference: SNOMEDCT_US:350102001
database_cross_reference: SNOMEDCT_US:422100001
database_cross_reference: SNOMEDCT_US:492000
database_cross_reference: VANDF:4020316
database_cross_reference: VANDF:4020317
database_cross_reference: VANDF:4025048

Petrolatum
type: Class
subclass of: Hydrocarbons
MCID: MC00009968
PMOID: PMO:00017042
Subclass_of: Hydrocarbons
Synonym: 7 Select Hemorrhoidal Original Strength
Synonym: A D and L Original Diaper Rash Skin
Synonym: A and D Diaper Rash and Skin Protectant
Synonym: A and D First Aid
Synonym: A and D plus E
Synonym: A+d Diaper Rash Ointment
Synonym: ATOPALM Hemorrhoidal Pain Relieving
Synonym: Advaced First Aid A and D
Synonym: Advanced Healing
Synonym: Advanced Petrolatum
Tree Number: T6.2.17.5
database_cross_reference: CHV:0000009559
database_cross_reference: CHV:0000027542
database_cross_reference: CSP:2254-3428
database_cross_reference: DRUGBANK:DB11058
database_cross_reference: LCH:U003587
database_cross_reference: LCH_NW:sh85100360
database_cross_reference: MMSL:10742
database_cross_reference: MMSL:37098
database_cross_reference: MMSL:5264
database_cross_reference: MMSL:5665
database_cross_reference: MMSL:71904
database_cross_reference: MMSL:71905
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D010577
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:4T6H12BN9U
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C29538
database_cross_reference: NCI_FDA:4T6H12BN9U
database_cross_reference: NCI_NCI-GLOSS:CDR0000476581
database_cross_reference: NCI_NCI-GLOSS:CDR0000572215
database_cross_reference: NDDF:002441
database_cross_reference: NDDF:008848
database_cross_reference: NDFRT:N0000006854
database_cross_reference: NDFRT:N0000146919
database_cross_reference: NDFRT:N0000147532
database_cross_reference: RCD:gg1..
database_cross_reference: RCD:kbB..
database_cross_reference: RCD:m127.
database_cross_reference: RCD:x02Dd
database_cross_reference: RXNORM:8091
database_cross_reference: SNM:E-8062
database_cross_reference: SNMI:C-93836
database_cross_reference: SNMI:C-93838
database_cross_reference: SNOMEDCT_US:25307002
database_cross_reference: SNOMEDCT_US:326647009
database_cross_reference: SNOMEDCT_US:330876005
database_cross_reference: SNOMEDCT_US:331371002
database_cross_reference: SNOMEDCT_US:353601006
database_cross_reference: SNOMEDCT_US:400737002
database_cross_reference: SNOMEDCT_US:5774007
database_cross_reference: VANDF:4018604
database_cross_reference: VANDF:4019373

Mineral Oil
type: Class
subclass of: Petrolatum
MCID: MC00008321
PMOID: PMO:00017043
Subclass_of: Petrolatum
Synonym: 7 Select Hemorrhoidal Original Strength
Synonym: Agarol Eml Strawberry
Synonym: Agarol Plain
Synonym: Agarol Plain Eml
Synonym: Agarol Vanilla Laxative Liq
Synonym: Amoray Care Baby
Synonym: Apj Hemorrhoidal
Synonym: Bath Oil Liq 63.4%
Synonym: Budpak Hemorrhoid Anesthetic
Synonym: CVS Nighttime Dry-Eye Relief
Tree Number: T6.2.17.5.1
database_cross_reference: ATC:A06AA01
database_cross_reference: CHV:0000008156
database_cross_reference: DRUGBANK:DB11057
database_cross_reference: DRUGBANK:DB11058
database_cross_reference: GS:47256
database_cross_reference: LCH:U002988
database_cross_reference: LCH_NW:sh85085568
database_cross_reference: MDDB:02382
database_cross_reference: MDDB:27689
database_cross_reference: MEDCIN:40918
database_cross_reference: MMSL:5117
database_cross_reference: MMSL:6322
database_cross_reference: MMSL:d01019
database_cross_reference: MMX:104585
database_cross_reference: MSH:D008899
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: MTHSPL:T5L8T28FGP
database_cross_reference: NCI:C29264
database_cross_reference: NCI_FDA:T5L8T28FGP
database_cross_reference: NCI_NCI-GLOSS:CDR0000486450
database_cross_reference: NDDF:001179
database_cross_reference: NDDF:001900
database_cross_reference: NDDF:002477
database_cross_reference: NDDF:008583
database_cross_reference: NDDF:014317
database_cross_reference: NDFRT:N0000006757
database_cross_reference: NDFRT:N0000146890
database_cross_reference: NDFRT:N0000148175
database_cross_reference: RCD:X79Bj
database_cross_reference: RCD:ad1..
database_cross_reference: RCD:ka3..
database_cross_reference: RCD:x02LD
database_cross_reference: RXNORM:6972
database_cross_reference: SNM:E-5427
database_cross_reference: SNM:E-8062
database_cross_reference: SNM:E-8281
database_cross_reference: SNMI:C-20241
database_cross_reference: SNMI:C-9383A
database_cross_reference: SNOMEDCT_US:111089004
database_cross_reference: SNOMEDCT_US:317567003
database_cross_reference: SNOMEDCT_US:330786000
database_cross_reference: SNOMEDCT_US:354035004
database_cross_reference: SNOMEDCT_US:398763008
database_cross_reference: SNOMEDCT_US:48350004
database_cross_reference: VANDF:4018574
database_cross_reference: VANDF:4020318

Terpenes
type: Class
subclass of: Hydrocarbons
MCID: MC00012622
PMOID: PMO:00017044
Subclass_of: Hydrocarbons
Synonym: Terpene
Synonym: Terpene (product)
Synonym: Terpene (substance)
Synonym: Terpene Compound
Synonym: Terpene, NOS
Synonym: Terpenes [Chemical/Ingredient]
Synonym: Terpenoids
Synonym: terpene
Synonym: terpenes
Synonym: terpenoid
Tree Number: T6.2.17.6
database_cross_reference: AOD:0000029112
database_cross_reference: AOD:0000029113
database_cross_reference: CHV:0000012112
database_cross_reference: CSP:2876-1788
database_cross_reference: LCH:U004620
database_cross_reference: LCH_NW:sh85134045
database_cross_reference: MSH:D013729
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C68542
database_cross_reference: NCI:C860
database_cross_reference: NCI_CRCH:C68542
database_cross_reference: NCI_NCI-GLOSS:CDR0000463097
database_cross_reference: NDFRT:N0000007940
database_cross_reference: RCD:x01GG
database_cross_reference: SNMI:C-31112
database_cross_reference: SNOMEDCT_US:415710007
database_cross_reference: SNOMEDCT_US:77549006

Cannabinoids
type: Class
subclass of: Terpenes
MCID: MC00002179
PMOID: PMO:00017045
Subclass_of: Terpenes
Synonym: Cannabinoid
Synonym: Cannabinoid (product)
Synonym: Cannabinoid (substance)
Synonym: Cannabinoid - non-pharmaceut
Synonym: Cannabinoid - non-pharmaceutical
Synonym: Cannabinoid - non-pharmaceutical (substance)
Synonym: Cannabinoids [Chemical/Ingredient]
Synonym: cannabinoid
Synonym: cannabinoids
Tree Number: T6.2.17.6.1
database_cross_reference: AOD:0000000713
database_cross_reference: CHV:0000002349
database_cross_reference: CSP:0396-2636
database_cross_reference: LCH:U000770
database_cross_reference: LCH_NW:sh85019609
database_cross_reference: LNC:LP16058-7
database_cross_reference: LNC:MTHU006737
database_cross_reference: MSH:D002186
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C105578
database_cross_reference: NDFRT:N0000008010
database_cross_reference: PSY:07436
database_cross_reference: RCD:Ub18N
database_cross_reference: RCD:X7955
database_cross_reference: SNMI:C-63A20
database_cross_reference: SNOMEDCT_US:228997001
database_cross_reference: SNOMEDCT_US:255642008
database_cross_reference: SNOMEDCT_US:39598004
database_cross_reference: SNOMEDCT_US:398705004
database_cross_reference: SNOMEDCT_US:421921003

Diterpenes
type: Class
subclass of: Terpenes
MCID: MC00004073
PMOID: PMO:00017049
Subclass_of: Terpenes
Synonym: Diterpenes [Chemical/Ingredient]
Synonym: Diterpenoids
Synonym: diterpene
Synonym: diterpenes
Tree Number: T6.2.17.6.3
database_cross_reference: AOD:0000020981
database_cross_reference: CHV:0000004043
database_cross_reference: CSP:2876-2100
database_cross_reference: LCH_NW:sh89005223
database_cross_reference: MSH:D004224
database_cross_reference: NDFRT:N0000008216

Aconitine
type: Class
subclass of: Alkaloids
MCID: MC00000259
PMOID: PMO:00017050
Subclass_of: Alkaloids
Synonym: (1Alpha,3Alpha,6Alpha,14Alpha,15Alpha,16Beta)-20-Ethyl-1,6,16-Trimethoxy-4-(Methoxymethyl)Aconitane-3,8,13,14,15-Pentol 8-Acetate 14-Benzoate
Synonym: ACONITINE
Synonym: Acetylbenzoyl aconine
Synonym: Acetylbenzoyl-aconine
Synonym: Acetylbenzoylaconine
Synonym: Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-
Synonym: Aconitine (substance)
Synonym: Aconitine [Chemical/Ingredient]
Synonym: Aconitinum
Synonym: aconitine
Tree Number: T6.3.3.1
database_cross_reference: CSP:0091-7950
database_cross_reference: MSH:D000157
database_cross_reference: MTHSPL:X8YN71D5WC
database_cross_reference: NCI:C87421
database_cross_reference: NCI_FDA:X8YN71D5WC
database_cross_reference: NDFRT:N0000166908
database_cross_reference: RXNORM:1441664
database_cross_reference: SNM:E-6862
database_cross_reference: SNMI:C-30314
database_cross_reference: SNOMEDCT_US:43360005

Atractyloside
type: Class
subclass of: PMO:00020950
MCID: MC00001356
PMOID: PMO:00017051
Subclass_of: Glycosides
Synonym: 19-Norkaur-16-en-18-oic acid, 15-hydroxy-2-((2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl)oxy)-, (2beta,4alpha,15alpha)-
Synonym: Acid, Atractylic
Synonym: Atractylate
Synonym: Atractylic Acid
Synonym: Atractyloside [Chemical/Ingredient]
Tree Number: T6.8.6.3
database_cross_reference: MSH:D001278
database_cross_reference: NDFRT:N0000168478

Ryanodine
type: Class
subclass of: Alkaloids
PMOID: PMO:00017059
Subclass_of: Alkaloids
Tree Number: T6.3.3.16

Gefarnate
type: Class
subclass of: Terpenes
subclass of: PMO:00021092
MCID: MC00005476
PMOID: PMO:00017066
Subclass_of: Fatty Acids, Unsaturated
Subclass_of: Terpenes
Synonym: 4,8,12-Tetradecatrienoic acid, 5,9,13-trimethyl-, 3,7-dimethyl-2,6-octadienyl ester, (E,E,E)-
Synonym: Farnesylacetate, Geranyl
Synonym: GEFARNATE
Synonym: Gefarnate [Chemical/Ingredient]
Synonym: Geranyl Farnesylacetate
Synonym: gefarnate
Tree Number: T6.2.17.6.5
Tree Number: T6.9.3.5.3
database_cross_reference: ATC:A02BX07
database_cross_reference: DRUGBANK:DB12079
database_cross_reference: MSH:D005778
database_cross_reference: NCI:C73187
database_cross_reference: NCI_FDA:1ISE2Y6ULA
database_cross_reference: NDFRT:N0000168575

Polyisoprenyl Phosphates
type: Class
subclass of: Terpenes
subclass of: Organophosphates
MCID: MC00010432
PMOID: PMO:00017067
Subclass_of: Organophosphates
Subclass_of: Terpenes
Synonym: Phosphates, Polyisoprenyl
Synonym: Polyisoprenyl Phosphates [Chemical/Ingredient]
Tree Number: T6.2.17.6.6
Tree Number: T6.2.29.5.10
database_cross_reference: MSH:D011106
database_cross_reference: NDFRT:N0000166419

Polyisoprenyl Phosphate Sugars
type: Class
subclass of: PMO:00020923
subclass of: PMO:00021046
MCID: MC00010431
PMOID: PMO:00017068
Subclass_of: Glycolipids
Subclass_of: Sugar Phosphates
Synonym: Isoprenoid Phosphate Sugars
Synonym: Phosphate Sugars, Isoprenoid
Synonym: Phosphate Sugars, Polyisoprenyl
Synonym: Polyisoprenyl Phosphate Sugars [Chemical/Ingredient]
Synonym: Pyrophosphorylpolyprenols, Sugar
Synonym: Sugar Pyrophosphorylpolyprenols
Synonym: Sugars, Isoprenoid Phosphate
Synonym: Sugars, Polyisoprenyl Phosphate
Tree Number: T6.8.10.7
Tree Number: T6.9.6.3
database_cross_reference: MSH:D011105
database_cross_reference: NDFRT:N0000168592

Polyisoprenyl Phosphate Monosaccharides
type: Class
subclass of: Polyisoprenyl Phosphate Sugars
MCID: MC00010429
PMOID: PMO:00017069
Subclass_of: Polyisoprenyl Phosphate Sugars
Synonym: Isoprenoid Phosphate Monosaccharides
Synonym: Monosaccharides, Isoprenoid Phosphate
Synonym: Monosaccharides, Polyisoprenyl Phosphate
Synonym: Phosphate Monosaccharides, Isoprenoid
Synonym: Phosphate Monosaccharides, Polyisoprenyl
Synonym: Polyisoprenyl Phosphate Monosaccharides [Chemical/Ingredient]
Tree Number: T6.8.10.7.1
Tree Number: T6.9.6.3.1
database_cross_reference: MSH:D011103
database_cross_reference: NDFRT:N0000168594

Polyisoprenyl Phosphate Oligosaccharides
type: Class
subclass of: Polyisoprenyl Phosphate Sugars
MCID: MC00010430
PMOID: PMO:00017071
Subclass_of: Polyisoprenyl Phosphate Sugars
Synonym: Isoprenoid Phosphate Oligosaccharides
Synonym: Oligosaccharides, Isoprenoid Phosphate
Synonym: Oligosaccharides, Polyisoprenyl Phosphate
Synonym: Phosphate Oligosaccharides, Isoprenoid
Synonym: Phosphate Oligosaccharides, Polyisoprenyl
Synonym: Polyisoprenyl Phosphate Oligosaccharides [Chemical/Ingredient]
Tree Number: T6.8.10.7.2
Tree Number: T6.9.6.3.2
database_cross_reference: MSH:D011104
database_cross_reference: NDFRT:N0000168593

Sesquiterpenes
type: Class
subclass of: Terpenes
MCID: MC00011790
PMOID: PMO:00017072
Subclass_of: Terpenes
Synonym: Sesquiterpenes [Chemical/Ingredient]
Synonym: sesquiterpene
Synonym: sesquiterpenes
Tree Number: T6.2.17.6.7
database_cross_reference: AOD:0000020980
database_cross_reference: CHV:0000011255
database_cross_reference: CSP:2876-3348
database_cross_reference: LCH_NW:sh89006047
database_cross_reference: MSH:D012717
database_cross_reference: NDFRT:N0000008045

Trichothecenes
type: Class
subclass of: Macrocyclic Compounds
subclass of: PMO:00024389
MCID: MC00013068
PMOID: PMO:00017075
Subclass_of: Macrocyclic Compounds
Subclass_of: Mycotoxins
Synonym: Fusarium toxins
Synonym: Fusarium toxins, NOS
Synonym: Trichothecene
Synonym: Trichothecenes (substance)
Synonym: Trichothecenes [Chemical/Ingredient]
Synonym: Trichothecenes, NOS
Synonym: trichothecene
Synonym: trichothecenes
Tree Number: T6.13.8.6.15
Tree Number: T6.4.5.5
database_cross_reference: CHV:0000012545
database_cross_reference: LCH:U004777
database_cross_reference: LCH_NW:sh85137481
database_cross_reference: LNC:LP64676-7
database_cross_reference: MSH:D014255
database_cross_reference: NDFRT:N0000171422
database_cross_reference: RCD:Xa3dn
database_cross_reference: SNMI:C-30830
database_cross_reference: SNOMEDCT_US:693002

T-2 Toxin
type: Class
subclass of: Trichothecenes
MCID: MC00012516
PMOID: PMO:00017076
Subclass_of: Trichothecenes
Synonym: Fusariotoxin
Synonym: Fusaritoxin
Synonym: Mycotoxin T2
Synonym: T 2 Toxin
Synonym: T AA TOXIN 02
Synonym: T-2 Toxin [Chemical/Ingredient]
Synonym: T-2 fungal toxin
Synonym: T-2 fungal toxin (substance)
Synonym: T-2 toxin
Synonym: T2 Toxin
Tree Number: T6.4.5.5.1
database_cross_reference: CHV:0000011997
database_cross_reference: CSP:5002-0061
database_cross_reference: MSH:D013605
database_cross_reference: NDFRT:N0000171423
database_cross_reference: SNMI:C-30832
database_cross_reference: SNOMEDCT_US:39979007

Trichodermin
type: Class
subclass of: Trichothecenes
MCID: MC00013059
PMOID: PMO:00017077
Subclass_of: Trichothecenes
Synonym: Trichodermin [Chemical/Ingredient]
Synonym: Trichothec-9-en-4-ol, 12,13-epoxy-, acetate, (4beta)-
Tree Number: T6.4.5.5.2
database_cross_reference: MSH:D014243
database_cross_reference: NDFRT:N0000171424

Triterpenes
type: Class
subclass of: Terpenes
MCID: MC00013138
PMOID: PMO:00017080
Subclass_of: Terpenes
Synonym: Triterpene
Synonym: Triterpene (substance)
Synonym: Triterpenes [Chemical/Ingredient]
Synonym: triterpene
Synonym: triterpenes
Tree Number: T6.2.17.6.8
database_cross_reference: AOD:0000020994
database_cross_reference: CHV:0000012587
database_cross_reference: CSP:2876-3599
database_cross_reference: MSH:D014315
database_cross_reference: NDFRT:N0000008180
database_cross_reference: SNOMEDCT_US:707161007

Lanosterol
type: Class
subclass of: Sterols
MCID: MC00007364
PMOID: PMO:00017081
Subclass_of: Sterols
Synonym: 4,4,14 alpha-trimethyl-5 alpha-cholesta-8,24-dien-3 beta-ol
Synonym: Kryptosterol
Synonym: LANOSTEROL
Synonym: Lanosta-8,24-dien-3-ol, (3beta)-
Synonym: Lanosterol (substance)
Synonym: Lanosterol [Chemical/Ingredient]
Synonym: lanosterol
Tree Number: T6.9.11.5.6
database_cross_reference: AOD:0000021033
database_cross_reference: CSP:0658-8662
database_cross_reference: DRUGBANK:DB03696
database_cross_reference: LNC:LP173718-0
database_cross_reference: LNC:MTHU047885
database_cross_reference: MSH:D007810
database_cross_reference: MTHSPL:1J05Z83K3M
database_cross_reference: NDFRT:N0000168617
database_cross_reference: RXNORM:1442199
database_cross_reference: SNM:F-14000
database_cross_reference: SNMI:F-63A00
database_cross_reference: SNOMEDCT_US:86155007

Sapogenins
type: Class
subclass of: Steroids
MCID: MC00011587
PMOID: PMO:00017082
Subclass_of: Steroids
Synonym: Sapogenins [Chemical/Ingredient]
Tree Number: T6.4.1.1.14
database_cross_reference: LCH_NW:sh97005876
database_cross_reference: MSH:D012502
database_cross_reference: NDFRT:N0000167410

Ginsenosides
type: Class
subclass of: PMO:00020988
MCID: MC00027544
PMOID: PMO:00017084
Subclass_of: Saponins
Synonym: GINSENOSIDES
Synonym: Ginsenosides [Chemical/Ingredient]
Synonym: Panaxosides
Synonym: Sanchinosides
Synonym: ginsenosides
Synonym: panaxosides
Tree Number: T6.8.6.15.4
database_cross_reference: CHV:0000014095
database_cross_reference: MSH:D036145
database_cross_reference: MTHSPL:3K198YD54P
database_cross_reference: NDFRT:N0000168477

Glaucarubin
type: Class
subclass of: Pyrans
MCID: MC00005619
PMOID: PMO:00017087
Subclass_of: Pyrans
Synonym: GLAUCARUBIN
Synonym: Glaucarubin (substance)
Synonym: Glaucarubin [Chemical/Ingredient]
Synonym: Kirondrin
Synonym: Picras-3-en-16-one, 11,20-epoxy-1,2,11,12-tetrahydroxy-15-(2-hydroxy-2-methyl-1-oxobutoxy)-, (1beta,2alpha,11beta,12alpha,15beta(S))-
Tree Number: T6.3.5.17.3
database_cross_reference: MSH:D005900
database_cross_reference: NCI:C76094
database_cross_reference: NCI_FDA:EH6H7VS52J
database_cross_reference: NDFRT:N0000167034
database_cross_reference: SNM:E-7377
database_cross_reference: SNMI:C-56143
database_cross_reference: SNOMEDCT_US:73803009

Escin
type: Class
subclass of: PMO:00020988
MCID: MC00004704
PMOID: PMO:00017089
Subclass_of: Saponins
Synonym: Aescin
Synonym: ESCIN
Synonym: Escin (product)
Synonym: Escin (substance)
Synonym: Escin [Chemical/Ingredient]
Synonym: Escina
Synonym: Eskuzan
Synonym: aescin
Synonym: escin
Synonym: escina
Tree Number: T6.8.6.15.1
database_cross_reference: CHV:0000004643
database_cross_reference: MSH:D004928
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:RUU8G67GQM
database_cross_reference: NDDF:005569
database_cross_reference: NDFRT:N0000168475
database_cross_reference: RXNORM:4065
database_cross_reference: SNMI:C-81A38
database_cross_reference: SNOMEDCT_US:702951009
database_cross_reference: SNOMEDCT_US:83055002

Monoterpenes
type: Class
subclass of: Terpenes
MCID: MC00224206
PMOID: PMO:00017094
Subclass_of: Terpenes
Synonym: Monoterpenes [Chemical/Ingredient]
Synonym: Monoterpenoids
Synonym: monoterpene
Synonym: monoterpenes
Tree Number: T6.2.17.6.9
database_cross_reference: AOD:0000020977
database_cross_reference: CSP:2876-2724
database_cross_reference: LCH_NW:sh85086975
database_cross_reference: MSH:D039821
database_cross_reference: NDFRT:N0000011283

Camphor
type: Class
subclass of: Ketones
MCID: MC00002164
PMOID: PMO:00017097
Subclass_of: Ketones
Synonym: (+)-Camphor
Synonym: (+)-bornan-2-one
Synonym: (1R)-(+)-camphor
Synonym: (1R,4R)-camphor
Synonym: (R)-(+)-camphor
Synonym: (R)-camphor
Synonym: 2-Bornanone
Synonym: 2-Camphanone
Synonym: 701 Dieda Zhengtong Yaogao Medicated Plaster
Synonym: 999 Itch Relief
Tree Number: T6.2.20.6
database_cross_reference: CHV:0000002328
database_cross_reference: CSP:0779-2529
database_cross_reference: DRUGBANK:DB01744
database_cross_reference: LCH:U000757
database_cross_reference: LCH_NW:sh85019223
database_cross_reference: LNC:LP17862-1
database_cross_reference: LNC:MTHU015641
database_cross_reference: MEDCIN:40724
database_cross_reference: MMSL:4343
database_cross_reference: MMSL:6005
database_cross_reference: MMX:105283
database_cross_reference: MSH:D002164
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5TJD82A1ET
database_cross_reference: NCI:C28136
database_cross_reference: NCI_NCI-GLOSS:CDR0000044001
database_cross_reference: NDDF:001385
database_cross_reference: NDDF:001993
database_cross_reference: NDDF:006104
database_cross_reference: NDFRT:N0000006667
database_cross_reference: NDFRT:N0000145916
database_cross_reference: RCD:X808O
database_cross_reference: RXNORM:1952
database_cross_reference: SNM:E-8003
database_cross_reference: SNMI:C-6B702
database_cross_reference: SNOMEDCT_US:111136003
database_cross_reference: SNOMEDCT_US:259118004
database_cross_reference: SNOMEDCT_US:412108007
database_cross_reference: VANDF:4017533

Iridoids
type: Class
subclass of: Pyrans
MCID: MC00377924
PMOID: PMO:00017103
Subclass_of: Pyrans
Synonym: Iridoids [Chemical/Ingredient]
Synonym: iridoid
Synonym: iridoids
Tree Number: T6.3.5.17.10
database_cross_reference: CHV:0000054972
database_cross_reference: MSH:D039823
database_cross_reference: NDFRT:N0000167173

Iridoid Glycosides
type: Class
subclass of: PMO:00020950
MCID: MC00797828
PMOID: PMO:00017104
Subclass_of: Glycosides
Synonym: Glycosides, Iridoid
Synonym: Iridoid Glycosides [Chemical/Ingredient]
Synonym: Iridoidglycosides
Tree Number: T6.8.6.20
database_cross_reference: MSH:D057889
database_cross_reference: NDFRT:N0000182090

Iridoid Glucosides
type: Class
subclass of: Iridoid Glycosides
subclass of: PMO:00020974
MCID: MC00029448
PMOID: PMO:00017105
Subclass_of: Glucosides
Subclass_of: Iridoid Glycosides
Synonym: Glucosides, Iridoid
Synonym: Iridoid Glucosides [Chemical/Ingredient]
Synonym: Iridoidglucosides
Tree Number: T6.8.6.20.1
Tree Number: T6.8.6.7.10
database_cross_reference: MSH:D057888
database_cross_reference: NDFRT:N0000182047

Hemiterpenes
type: Class
subclass of: Terpenes
MCID: MC00421758
PMOID: PMO:00017106
Subclass_of: Terpenes
Synonym: Hemiterpenes [Chemical/Ingredient]
Tree Number: T6.2.17.6.10
database_cross_reference: MSH:D045782
database_cross_reference: NDFRT:N0000166348

Sesterterpenes
type: Class
subclass of: Terpenes
MCID: MC00037649
PMOID: PMO:00017107
Subclass_of: Terpenes
Synonym: Sesterterpenes [Chemical/Ingredient]
Tree Number: T6.2.17.6.11
database_cross_reference: MSH:D054830
database_cross_reference: NDFRT:N0000178604

Imides
type: Class
subclass of: Organic Chemicals
MCID: MC00006717
PMOID: PMO:00017108
Subclass_of: Organic Chemicals
Synonym: Imide
Synonym: Imide (substance)
Synonym: Imides [Chemical/Ingredient]
Synonym: imide
Synonym: imides
Tree Number: T6.2.18
database_cross_reference: AOD:0000020107
database_cross_reference: CHV:0000006567
database_cross_reference: CSP:1551-4059
database_cross_reference: LCH:U002369
database_cross_reference: LCH_NW:sh85064493
database_cross_reference: MSH:D007094
database_cross_reference: NDFRT:N0000008189
database_cross_reference: RCD:Xa85b
database_cross_reference: SNOMEDCT_US:116651007

Imidoesters
type: Class
subclass of: Imides
MCID: MC00006719
PMOID: PMO:00017109
Subclass_of: Imides
Synonym: Imidoesters [Chemical/Ingredient]
Synonym: imidoester
Tree Number: T6.2.18.1
database_cross_reference: CSP:2077-7189
database_cross_reference: LCH:U002370
database_cross_reference: LCH_NW:sh85064494
database_cross_reference: MSH:D007096
database_cross_reference: NDFRT:N0000166622

Dimethyl Suberimidate
type: Class
subclass of: Imidoesters
MCID: MC00003960
PMOID: PMO:00017110
Subclass_of: Imidoesters
Synonym: Bismethyl Suberimidate
Synonym: Dimethyl Suberimidate [Chemical/Ingredient]
Synonym: Dimethylsuberimidate
Synonym: Octanediimidic acid, dimethyl ester
Synonym: Suberimidate, Bismethyl
Synonym: Suberimidate, Dimethyl
Tree Number: T6.2.18.1.2
database_cross_reference: MSH:D004120
database_cross_reference: NDFRT:N0000166623

Pantothenic Acid
type: Class
subclass of: Imides
MCID: MC00009684
PMOID: PMO:00017111
Subclass_of: Imides
Synonym: (+)-Pantothenic acid
Synonym: Acti Pantothenic Acid 1000 Timed Caplet
Synonym: Acti-pantothenic Acid 300 Caplet 300mg
Synonym: Adrenergy Tablets
Synonym: Adrenogist Tab
Synonym: Advanced 2000 Capsules
Synonym: Allbee With C 550 Cap
Synonym: Allbee With Vitamin C Cap
Synonym: American Eagle Energizer Plus Vitamin Supplement Drink
Synonym: American Plus Energy & Vitamin Drink
Tree Number: T6.2.18.3
database_cross_reference: AOD:0000018235
database_cross_reference: CHV:0000009239
database_cross_reference: DRUGBANK:DB01783
database_cross_reference: DRUGBANK:DB09462
database_cross_reference: DRUGBANK:DB11074
database_cross_reference: LCH_NW:sh2001002934
database_cross_reference: MEDCIN:199132
database_cross_reference: MMSL:5685
database_cross_reference: MMSL:7440
database_cross_reference: MSH:D010205
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:19F5HK2737
database_cross_reference: NCI:C47783
database_cross_reference: NCI_CRCH:C47783
database_cross_reference: NCI_DCP:30598
database_cross_reference: NCI_FDA:19F5HK2737
database_cross_reference: NCI_NCI-GLOSS:CDR0000556408
database_cross_reference: NCI_NCI-GLOSS:CDR0000629158
database_cross_reference: NDDF:001056
database_cross_reference: NDFRT:N0000007356
database_cross_reference: NDFRT:N0000146048
database_cross_reference: NDFRT:N0000148499
database_cross_reference: RCD:X80RL
database_cross_reference: RXNORM:7891
database_cross_reference: SNM:F-16350
database_cross_reference: SNMI:C-A4430
database_cross_reference: SNMI:F-BB450
database_cross_reference: SNOMEDCT_US:66441000
database_cross_reference: SNOMEDCT_US:86431009
database_cross_reference: VANDF:4017672
database_cross_reference: VANDF:4021034

Succinimides
type: Class
subclass of: Imides
MCID: MC00012341
PMOID: PMO:00017112
Subclass_of: Imides
Synonym: 61B SUCCINIMIDES
Synonym: Butanimides
Synonym: Pyrrolidinediones
Synonym: SUCCINIMIDES
Synonym: Succinimide
Synonym: Succinimide (product)
Synonym: Succinimide (substance)
Synonym: Succinimide antiepileptic
Synonym: Succinimides [Chemical/Ingredient]
Synonym: succinimide
Tree Number: T6.2.18.5
database_cross_reference: CHV:0000011830
database_cross_reference: LCH_NW:sh99005595
database_cross_reference: MSH:D013388
database_cross_reference: MTH:U002274
database_cross_reference: NDFRT:N0000007926
database_cross_reference: RCD:x01Bh
database_cross_reference: SNMI:C-61B00
database_cross_reference: SNOMEDCT_US:372837008
database_cross_reference: SNOMEDCT_US:74632002

Bromosuccinimide
type: Class
subclass of: Succinimides
MCID: MC00001964
PMOID: PMO:00017113
Subclass_of: Succinimides
Synonym: 2,5-Pyrrolidinedione, bromo-
Synonym: Bromosuccinimide [Chemical/Ingredient]
Synonym: N Bromosuccinimide
Synonym: N-Bromosuccinimide
Synonym: Succinbromimide
Tree Number: T6.2.18.5.1
database_cross_reference: LCH_NW:sh99005592
database_cross_reference: MSH:D001974
database_cross_reference: NDFRT:N0000167155

Ethosuximide
type: Class
subclass of: Succinimides
MCID: MC00004784
PMOID: PMO:00017114
Subclass_of: Succinimides
Synonym: (+-)-2-Ethyl-2-methylsuccinimide
Synonym: (Â±)-2-ethyl-2-methylsuccinimide
Synonym: 2,5-Pyrrolidinedione, 3-ethyl-3-methyl-
Synonym: 2-Methyl-2-ethylsuccinimide
Synonym: 2-ethyl-2-methylsuccinimide
Synonym: 3-Ethyl-3-methylpyrrolidine-2,5-dione
Synonym: 3-Ethyl-3-methylsuccinimide
Synonym: 3-Methyl-3-ethylpyrrolidine-2,5-dione
Synonym: 3-Methyl-3-ethylsuccinimide
Synonym: 3-ethyl-3-methyl-2,5-pyrrolidinedione
Tree Number: T6.2.18.5.2
database_cross_reference: ATC:N03AD01
database_cross_reference: CHV:0000004709
database_cross_reference: CSP:2521-1649
database_cross_reference: DRUGBANK:DB00593
database_cross_reference: LNC:LP16137-9
database_cross_reference: LNC:MTHU004937
database_cross_reference: MEDCIN:41096
database_cross_reference: MMSL:4199
database_cross_reference: MMSL:4701
database_cross_reference: MMSL:d00227
database_cross_reference: MSH:D005013
database_cross_reference: MTH:U001910
database_cross_reference: MTHSPL:5SEH9X1D1D
database_cross_reference: NCI:C47523
database_cross_reference: NCI_FDA:5SEH9X1D1D
database_cross_reference: NDDF:001631
database_cross_reference: NDFRT:N0000006713
database_cross_reference: NDFRT:N0000146944
database_cross_reference: RCD:dn5..
database_cross_reference: RXNORM:4135
database_cross_reference: SNM:E-7813
database_cross_reference: SNMI:C-61B10
database_cross_reference: SNOMEDCT_US:322899006
database_cross_reference: SNOMEDCT_US:387244008
database_cross_reference: SNOMEDCT_US:44790008
database_cross_reference: USPMG:MTHU000253
database_cross_reference: VANDF:4018631

Naphthalimides
type: Class
subclass of: Naphthalenes
subclass of: Imides
MCID: MC00583204
PMOID: PMO:00017115
Subclass_of: Imides
Subclass_of: Naphthalenes
Synonym: Naphthalimides [Chemical/Ingredient]
Tree Number: T6.2.18.6
Tree Number: T6.4.3.7.20
database_cross_reference: MSH:D053644
database_cross_reference: NDFRT:N0000175101

Imines
type: Class
subclass of: Organic Chemicals
MCID: MC00006720
PMOID: PMO:00017116
Subclass_of: Organic Chemicals
Synonym: Imines [Chemical/Ingredient]
Synonym: imine
Synonym: imines
Tree Number: T6.2.19
database_cross_reference: AOD:0000020106
database_cross_reference: CSP:1551-5929
database_cross_reference: LCH:U002371
database_cross_reference: LCH_NW:sh85064495
database_cross_reference: MSH:D007097
database_cross_reference: NDFRT:N0000008190

Carbodiimides
type: Class
subclass of: Imines
MCID: MC00002226
PMOID: PMO:00017117
Subclass_of: Imines
Synonym: Carbodiimides [Chemical/Ingredient]
Tree Number: T6.2.19.1
database_cross_reference: LCH_NW:sh2007002209
database_cross_reference: MSH:D002234
database_cross_reference: NDFRT:N0000166413

CME-Carbodiimide
type: Class
subclass of: Carbodiimides
MCID: MC00003000
PMOID: PMO:00017118
Subclass_of: Carbodiimides
Synonym: 4-(2-((Cyclohexylimidocarbonyl)amino)ethyl)-4-methylmorpholinium
Synonym: CME Carbodiimide
Synonym: CME-Carbodiimide [Chemical/Ingredient]
Synonym: CMEC
Synonym: Carbodiimide, CME
Synonym: Morpholinium, 4-(2-((cyclohexylcarbonimidoyl)amino)ethyl)-4-methyl-, salt with 4-methylbenzenesulfonic acid (1:1)
Tree Number: T6.2.19.1.1
database_cross_reference: MSH:D003028
database_cross_reference: NDFRT:N0000166416

Dicyclohexylcarbodiimide
type: Class
subclass of: Carbodiimides
MCID: MC00003867
PMOID: PMO:00017119
Subclass_of: Carbodiimides
Synonym: Cyclohexanamine, N,N'-methanetetraylbis-
Synonym: DCCD
Synonym: Dicyclohexylcarbodiimide [Chemical/Ingredient]
Tree Number: T6.2.19.1.3
database_cross_reference: MSH:D004024
database_cross_reference: NDFRT:N0000166414

Ethyldimethylaminopropyl Carbodiimide
type: Class
subclass of: Carbodiimides
MCID: MC00004796
PMOID: PMO:00017120
Subclass_of: Carbodiimides
Synonym: 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-
Synonym: 1-Ethyl-3-(3-Dimethylaminopropyl)Carbodiimide
Synonym: 3-(3-Dimethylaminopropyl)-1-Ethylcarbodiimide
Synonym: Carbodiimide, Ethyldimethylaminopropyl
Synonym: EDAP Carbodiimide
Synonym: EDAP-Carbodiimide
Synonym: Ethyldimethylaminopropyl Carbodiimide [Chemical/Ingredient]
Tree Number: T6.2.19.1.4
database_cross_reference: MSH:D005022
database_cross_reference: NDFRT:N0000166415

Schiff Bases
type: Class
subclass of: Imines
MCID: MC00011634
PMOID: PMO:00017121
Subclass_of: Imines
Synonym: Base, Schiff
Synonym: Bases, Schiff
Synonym: Schiff Base
Synonym: Schiff Bases [Chemical/Ingredient]
Synonym: Schiff base
Synonym: Schiff bases
Synonym: schiff base
Synonym: schiff bases
Tree Number: T6.2.19.4
database_cross_reference: CHV:0000011076
database_cross_reference: CSP:1551-6810
database_cross_reference: LCH:U004224
database_cross_reference: LCH_NW:sh85118118
database_cross_reference: MSH:D012545
database_cross_reference: NDFRT:N0000166412

Imino Sugars
type: Class
subclass of: Imines
subclass of: PMO:00020868
MCID: MC00540134
PMOID: PMO:00017122
Subclass_of: Carbohydrates
Subclass_of: Imines
Synonym: Imino Sugars [Chemical/Ingredient]
Synonym: Imino sugars
Synonym: Sugars, Imino
Tree Number: T6.2.19.5
Tree Number: T6.8.11
database_cross_reference: LCH_NW:sh2007003871
database_cross_reference: MSH:D050111
database_cross_reference: NDFRT:N0000168504

Imino Pyranoses
type: Class
subclass of: Imino Sugars
subclass of: Piperidines
MCID: MC00540135
PMOID: PMO:00017123
Subclass_of: Imino Sugars
Subclass_of: Piperidines
Synonym: 1 N Imino Sugars
Synonym: 1,5 Imino Sugars
Synonym: 1,5-Imino Sugars
Synonym: 1-N-Imino Sugars
Synonym: 5 Imino Pyranoses
Synonym: 5-Imino-Pyranoses
Synonym: Imino Pyranoses [Chemical/Ingredient]
Synonym: Pyranoses, Imino
Synonym: Sugars, 1,5-Imino
Synonym: Sugars, 1-N-Imino
Tree Number: T6.2.19.5.1
Tree Number: T6.3.5.16.32
Tree Number: T6.8.11.1
database_cross_reference: MSH:D050112
database_cross_reference: NDFRT:N0000168505

1-Deoxynojirimycin
type: Class
subclass of: Imino Pyranoses
subclass of: Alkaloids
MCID: MC00044361
PMOID: PMO:00017124
Subclass_of: Alkaloids
Subclass_of: Imino Pyranoses
Synonym: 1 Deoxynojirimycin
Synonym: 1 Deoxynojirimycin (product)
Synonym: 1 Deoxynojirimycin (substance)
Synonym: 1 deoxynojirimycin
Synonym: 1,5-dideoxy-1,5-imino-D-glucitol
Synonym: 1-Deoxynojirimycin [Chemical/Ingredient]
Synonym: 1-deoxynojirimycin
Synonym: 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))-
Synonym: 5-amino-1,5-dideoxy-D-glucopyranose
Synonym: D-1-deoxynojirimycin
Tree Number: T6.3.3.24
Tree Number: T6.8.11.1.1
database_cross_reference: DRUGBANK:DB03206
database_cross_reference: MSH:D017485
database_cross_reference: NDFRT:N0000167204
database_cross_reference: SNOMEDCT_US:427912008
database_cross_reference: SNOMEDCT_US:428711006

Imino Furanoses
type: Class
subclass of: Imino Sugars
subclass of: Pyrrolidines
MCID: MC00540137
PMOID: PMO:00017125
Subclass_of: Imino Sugars
Subclass_of: Pyrrolidines
Synonym: 1,4 Imino Sugars
Synonym: 1,4-Imino Sugars
Synonym: Furanoses, Imino
Synonym: Hydroxy Methyl Pyrrolidines
Synonym: Hydroxy-Methyl-Pyrrolidines
Synonym: Hydroxymethylpyrrolidines
Synonym: Imino Furanoses [Chemical/Ingredient]
Synonym: Sugars, 1,4-Imino
Tree Number: T6.2.19.5.2
Tree Number: T6.3.5.22.14
Tree Number: T6.8.11.2
database_cross_reference: MSH:D050113
database_cross_reference: NDFRT:N0000168506

Ketones
type: Class
subclass of: Organic Chemicals
MCID: MC00007232
PMOID: PMO:00017126
Subclass_of: Organic Chemicals
Synonym: 215 KETONES
Synonym: KETONES
Synonym: Ketone
Synonym: Ketone (substance)
Synonym: Ketone, NOS
Synonym: Ketones [Chemical/Ingredient]
Synonym: ketone
Synonym: ketones
Tree Number: T6.2.20
database_cross_reference: AOD:0000018470
database_cross_reference: CHV:0000007078
database_cross_reference: CSP:1675-9604
database_cross_reference: LCH:U002577
database_cross_reference: LCH_NW:sh85072095
database_cross_reference: LNC:LP15683-3
database_cross_reference: LNC:MTHU003407
database_cross_reference: MSH:D007659
database_cross_reference: MTH:U000291
database_cross_reference: MTH:U000379
database_cross_reference: MTH:U002025
database_cross_reference: NCI:C94716
database_cross_reference: NCI_NCI-GLOSS:CDR0000463123
database_cross_reference: NDFRT:N0000008109
database_cross_reference: RCD:XC0Qf
database_cross_reference: SNM:E-5640
database_cross_reference: SNM:U000138
database_cross_reference: SNMI:C-21500
database_cross_reference: SNOMEDCT_US:259390003
database_cross_reference: SNOMEDCT_US:59431004

Acetone
type: Class
subclass of: Ketones
MCID: MC00000189
PMOID: PMO:00017127
Subclass_of: Ketones
Synonym: 2-Propanone
Synonym: ACETONE
Synonym: Acetone (substance)
Synonym: Acetone [Chemical/Ingredient]
Synonym: Acetone product
Synonym: Acetone product (product)
Synonym: Acetone product (substance)
Synonym: Dimethyl Formaldehyde
Synonym: Methyl Ketone
Synonym: acetone
Tree Number: T6.2.20.1
database_cross_reference: AOD:0000019805
database_cross_reference: CHV:0000000608
database_cross_reference: CSP:1675-9731
database_cross_reference: LCH:U000025
database_cross_reference: LCH_NW:sh85000462
database_cross_reference: LNC:LP16798-8
database_cross_reference: LNC:MTHU004900
database_cross_reference: MEDCIN:40694
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000096
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:1364PS73AF
database_cross_reference: NCI:C29807
database_cross_reference: NCI_FDA:1364PS73AF
database_cross_reference: NDDF:002463
database_cross_reference: NDFRT:N0000007389
database_cross_reference: NDFRT:N0000147297
database_cross_reference: RCD:X808o
database_cross_reference: RXNORM:178
database_cross_reference: SNM:E-5641
database_cross_reference: SNMI:C-21506
database_cross_reference: SNOMEDCT_US:333511003
database_cross_reference: SNOMEDCT_US:4370008
database_cross_reference: VANDF:4019024

Acetophenones
type: Class
subclass of: Ketones
MCID: MC00000192
PMOID: PMO:00017128
Subclass_of: Ketones
Synonym: ACETOPHENONE
Synonym: Acetophenone
Synonym: Acetophenones [Chemical/Ingredient]
Tree Number: T6.2.20.2
database_cross_reference: DRUGBANK:DB04619
database_cross_reference: LCH_NW:sh2005002607
database_cross_reference: MSH:D000098
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008117

Benzoin
type: Class
subclass of: Acetophenones
MCID: MC00241490
PMOID: PMO:00017129
Subclass_of: Acetophenones
Synonym: BENZOIN COMPOUND
Synonym: Benzoin Compound
Synonym: Benzoin Compound Tincture
Synonym: Benzoin Compound Tincture Professional Pack
Synonym: Benzoin absolute
Synonym: Benzoin compound tincture
Synonym: Benzoinspray - Aer 25%
Synonym: Chase Coldsorex
Synonym: Compound Benzoin
Synonym: Compound Benzoin Tincture
Tree Number: T6.2.20.2.1
database_cross_reference: CHV:0000045411
database_cross_reference: CHV:0000057731
database_cross_reference: DRUGBANK:DB00898
database_cross_reference: DRUGBANK:DB11222
database_cross_reference: MDDB:05977
database_cross_reference: MMSL:4259
database_cross_reference: MMSL:8352
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:001923
database_cross_reference: NDFRT:N0000148285
database_cross_reference: RCD:cf11.
database_cross_reference: RXNORM:215648
database_cross_reference: SNM:E-8040
database_cross_reference: SNMI:C-93020
database_cross_reference: SNOMEDCT_US:387484002
database_cross_reference: SNOMEDCT_US:83459002
database_cross_reference: VANDF:4020598

omega-Chloroacetophenone
type: Class
subclass of: Acetophenones
MCID: MC00002658
PMOID: PMO:00017130
Subclass_of: Acetophenones
Synonym: 2 Chloro 1 phenylethanone
Synonym: 2 Chloroacetophenone
Synonym: 2-Chloro-1-phenylethanone
Synonym: 2-Chloroacetophenone
Synonym: CHLOROACETOPHENONE 02
Synonym: Chloracetophenone
Synonym: Chloroacetophenone
Synonym: Ethanone, 2-chloro-1-phenyl-
Synonym: alpha Chloroacetophenone
Synonym: alpha-Chloroacetophenone
Tree Number: T6.2.20.2.2
database_cross_reference: LNC:MTHU027446
database_cross_reference: MSH:D002721
database_cross_reference: MTH:U001806
database_cross_reference: NDFRT:N0000166797
database_cross_reference: SNMI:C-21124
database_cross_reference: SNOMEDCT_US:32601005

Butanones
type: Class
subclass of: Ketones
MCID: MC00002047
PMOID: PMO:00017131
Subclass_of: Ketones
Synonym: Butanones [Chemical/Ingredient]
Tree Number: T6.2.20.4
database_cross_reference: MSH:D002074
database_cross_reference: NDFRT:N0000007852

Acetoin
type: Class
subclass of: Butanones
MCID: MC00000186
PMOID: PMO:00017132
Subclass_of: Butanones
Synonym: 2-Butanone, 3-hydroxy-
Synonym: 3-hydroxy-2-butanone
Synonym: 3H-2B butanone
Synonym: Acetoin [Chemical/Ingredient]
Synonym: Acetylmethylcarbinol
Synonym: acetoin
Tree Number: T6.2.20.4.1
database_cross_reference: AOD:0000019703
database_cross_reference: MSH:D000093
database_cross_reference: NDFRT:N0000166800

Diacetyl
type: Class
subclass of: Butanones
MCID: MC00003808
PMOID: PMO:00017133
Subclass_of: Butanones
Synonym: 2,3 Butanedione
Synonym: 2,3-Butanedione
Synonym: BUTANEDIONE 02 03
Synonym: Biacetyl
Synonym: Butane-2,3-dione
Synonym: Butane-2,3-dione (substance)
Synonym: Diacetyl [Chemical/Ingredient]
Synonym: Diketobutane
Synonym: Dimethyl diketone
Synonym: Dimethyldiketone
Tree Number: T6.2.20.4.2
database_cross_reference: CHV:0000003848
database_cross_reference: LCH_NW:sh2007008577
database_cross_reference: MSH:D003931
database_cross_reference: NDFRT:N0000166801
database_cross_reference: RCD:X809G
database_cross_reference: SNOMEDCT_US:259140008

Thenoyltrifluoroacetone
type: Class
subclass of: Butanones
subclass of: Thiophenes
MCID: MC00012691
PMOID: PMO:00017134
Subclass_of: Butanones
Subclass_of: Thiophenes
Synonym: .alpha.-Thenoyltrifluoroacetone
Synonym: 1,1,1-Trifluoro-3-(2-thenoyl)acetone
Synonym: 1,3-Butanedione, 4,4,4-trifluoro-1-(2-thienyl)-
Synonym: 1-Thenoyl-3,3,3-trifluoroacetone
Synonym: 2-Thenoyltrifluoroacetone
Synonym: 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione
Synonym: Perfluoroacetyl(2-thenoyl)methane
Synonym: TTFA
Synonym: TTFA cpd
Synonym: Thenoyltrifluoroacetone [Chemical/Ingredient]
Tree Number: T6.2.20.4.3
Tree Number: T6.2.32.22.11
Tree Number: T6.3.5.25.10
database_cross_reference: DRUGBANK:DB04795
database_cross_reference: MSH:D013804
database_cross_reference: NDFRT:N0000167170

Butyrophenones
type: Class
subclass of: Ketones
MCID: MC00002063
PMOID: PMO:00017135
Subclass_of: Ketones
Synonym: 1-phenylbutan-1-one
Synonym: BUTYROPHENONE
Synonym: Butyrophenone
Synonym: Butyrophenone (substance)
Synonym: Butyrophenone product
Synonym: Butyrophenones [Chemical/Ingredient]
Synonym: butyrophenone
Synonym: butyrophenone (medication)
Synonym: butyrophenones
Tree Number: T6.2.20.5
database_cross_reference: AOD:0000019360
database_cross_reference: CHV:0000002262
database_cross_reference: CSP:2264-1137
database_cross_reference: MEDCIN:41363
database_cross_reference: MSH:D002090
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C323
database_cross_reference: NCI_FDA:186I11WB5B
database_cross_reference: NDFRT:N0000007863
database_cross_reference: PDQ:CDR0000040321
database_cross_reference: RCD:XM0lg
database_cross_reference: RCD:x001f
database_cross_reference: SNM:E-7919
database_cross_reference: SNOMEDCT_US:273961005
database_cross_reference: SNOMEDCT_US:6517004

Azaperone
type: Class
subclass of: Butyrophenones
MCID: MC00001430
PMOID: PMO:00017136
Subclass_of: Butyrophenones
Synonym: 1-Butanone, 1-(4-fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-
Synonym: AZAPERONE
Synonym: Azaperone (substance)
Synonym: Azaperone [Chemical/Ingredient]
Synonym: azaperone
Tree Number: T6.2.20.5.1
database_cross_reference: CHV:0000001636
database_cross_reference: MSH:D001376
database_cross_reference: NCI:C74187
database_cross_reference: NCI_FDA:19BV78AK7W
database_cross_reference: NDFRT:N0000166792
database_cross_reference: SNMI:C-640A0
database_cross_reference: SNOMEDCT_US:96229001

Benperidol
type: Class
subclass of: Butyrophenones
MCID: MC00001555
PMOID: PMO:00017137
Subclass_of: Butyrophenones
Synonym: 2H-Benzimidazol-2-one, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl)-1,3-dihydro-
Synonym: BENPERIDOL
Synonym: Benperidol (product)
Synonym: Benperidol (substance)
Synonym: Benperidol - chemical
Synonym: Benperidol - chemical (substance)
Synonym: Benperidol [Chemical/Ingredient]
Synonym: benperidol
Synonym: benperidol (medication)
Tree Number: T6.2.20.5.2
database_cross_reference: ATC:N05AD07
database_cross_reference: DRUGBANK:DB12867
database_cross_reference: LNC:LP199523-4
database_cross_reference: LNC:MTHU050805
database_cross_reference: MEDCIN:198827
database_cross_reference: MSH:D001544
database_cross_reference: NCI:C81086
database_cross_reference: NCI_FDA:97O6X78C53
database_cross_reference: NDDF:003934
database_cross_reference: NDFRT:N0000166794
database_cross_reference: RCD:d42..
database_cross_reference: RXNORM:1373
database_cross_reference: SNOMEDCT_US:321391002
database_cross_reference: SNOMEDCT_US:391820006

Droperidol
type: Class
subclass of: Butyrophenones
MCID: MC00004174
PMOID: PMO:00017138
Subclass_of: Butyrophenones
Synonym: 1-(1-(3-(P-Fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
Synonym: 1-(1-(4-(P-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
Synonym: 1-{1-[4-(4-fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Synonym: 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[D]imidazol-2-one
Synonym: 2H-Benzimidazol-2-one, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridinyl)-1,3-dihydro-
Synonym: DROPERIDOL
Synonym: Dridol
Synonym: Dropedol
Synonym: Dropel
Synonym: Droperdal
Tree Number: T6.2.20.5.3
database_cross_reference: ATC:N05AD08
database_cross_reference: CHV:0000004123
database_cross_reference: CSP:0393-0157
database_cross_reference: DRUGBANK:DB00450
database_cross_reference: LNC:LP18863-8
database_cross_reference: LNC:MTHU006087
database_cross_reference: MEDCIN:41407
database_cross_reference: MMSL:3392
database_cross_reference: MMSL:4646
database_cross_reference: MMSL:d00219
database_cross_reference: MSH:D004329
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:O9U0F09D5X
database_cross_reference: NCI:C458
database_cross_reference: NCI_FDA:O9U0F09D5X
database_cross_reference: NCI_NCI-GLOSS:CDR0000467837
database_cross_reference: NDDF:001517
database_cross_reference: NDFRT:N0000006827
database_cross_reference: NDFRT:N0000147316
database_cross_reference: PDQ:CDR0000039227
database_cross_reference: RCD:d44..
database_cross_reference: RCD:o54..
database_cross_reference: RCD:x02LP
database_cross_reference: RCDAE:o54..
database_cross_reference: RXNORM:3648
database_cross_reference: SNM:E-7921
database_cross_reference: SNMI:C-63210
database_cross_reference: SNOMEDCT_US:26574002
database_cross_reference: SNOMEDCT_US:321398008
database_cross_reference: SNOMEDCT_US:334009009
database_cross_reference: SNOMEDCT_US:387146001
database_cross_reference: VANDF:4019047

Haloperidol
type: Class
subclass of: Butyrophenones
MCID: MC00005931
PMOID: PMO:00017139
Subclass_of: Butyrophenones
Synonym: 1-(3-P-Fluorobenzoylpropyl)-4-P-chlorophenyl-4-hydroxypiperidine
Synonym: 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-
Synonym: 4'-Fluoro-4-(4-(P-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone
Synonym: 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone
Synonym: 4-(4-(Para-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
Synonym: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
Synonym: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
Synonym: Aloperidin
Synonym: Apo Haloperidol Liq 2mg/ml
Synonym: Apo Haloperidol Tab 0.5mg
Tree Number: T6.2.20.5.4
database_cross_reference: AOD:0000019806
database_cross_reference: ATC:N05AD01
database_cross_reference: CCPSS:1005820
database_cross_reference: CHV:0000005782
database_cross_reference: CSP:2332-7090
database_cross_reference: DRUGBANK:DB00502
database_cross_reference: LNC:LP16158-5
database_cross_reference: LNC:MTHU005005
database_cross_reference: MEDCIN:41370
database_cross_reference: MMSL:4816
database_cross_reference: MMSL:583
database_cross_reference: MMSL:d00027
database_cross_reference: MSH:D006220
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:J6292F8L3D
database_cross_reference: NCI:C537
database_cross_reference: NCI_DCP:00482
database_cross_reference: NCI_DTP:NSC0615296
database_cross_reference: NCI_FDA:J6292F8L3D
database_cross_reference: NCI_NCI-GLOSS:CDR0000476306
database_cross_reference: NDDF:001518
database_cross_reference: NDFRT:N0000006048
database_cross_reference: NDFRT:N0000146461
database_cross_reference: PDQ:CDR0000039474
database_cross_reference: PSY:22180
database_cross_reference: RCD:d47..
database_cross_reference: RCD:ds1..
database_cross_reference: RCD:x02LR
database_cross_reference: RXNORM:5093
database_cross_reference: SNM:E-7919
database_cross_reference: SNMI:C-63220
database_cross_reference: SNOMEDCT_US:10756001
database_cross_reference: SNOMEDCT_US:321415008
database_cross_reference: SNOMEDCT_US:323259009
database_cross_reference: SNOMEDCT_US:386837002
database_cross_reference: USPMG:MTHU000605
database_cross_reference: VANDF:4018123

Trifluperidol
type: Class
subclass of: Butyrophenones
MCID: MC00013083
PMOID: PMO:00017140
Subclass_of: Butyrophenones
Synonym: 1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-
Synonym: TRIFLUPERIDOL
Synonym: Trifluperidol (product)
Synonym: Trifluperidol (substance)
Synonym: Trifluperidol [Chemical/Ingredient]
Synonym: Trifluridol
Synonym: trifluperidol
Tree Number: T6.2.20.5.6
database_cross_reference: ATC:N05AD02
database_cross_reference: MSH:D014272
database_cross_reference: NCI:C76455
database_cross_reference: NCI_FDA:R8869Q7R8I
database_cross_reference: NDDF:004060
database_cross_reference: NDFRT:N0000166793
database_cross_reference: RCD:d4i..
database_cross_reference: RXNORM:10804
database_cross_reference: SNMI:C-63240
database_cross_reference: SNOMEDCT_US:387301006
database_cross_reference: SNOMEDCT_US:5478006

Hexanones
type: Class
subclass of: Ketones
MCID: MC00006239
PMOID: PMO:00017141
Subclass_of: Ketones
Synonym: Hexanone
Synonym: Hexanone (substance)
Synonym: Hexanones [Chemical/Ingredient]
Tree Number: T6.2.20.8
database_cross_reference: MSH:D006588
database_cross_reference: NDFRT:N0000166798
database_cross_reference: RCD:Xa7Ns
database_cross_reference: SNOMEDCT_US:299997004

Methyl n-Butyl Ketone
type: Class
subclass of: Hexanones
MCID: MC00008207
PMOID: PMO:00017142
Subclass_of: Hexanones
Synonym: 2 Hexanone
Synonym: 2-Hexanone
Synonym: Butyl methyl ketone
Synonym: Butyl methyl ketone (substance)
Synonym: Butylmethyl Ketone
Synonym: Butylmethyl ketone
Synonym: HEXAN 002
Synonym: HEXANONE 02
Synonym: Hexan 2 one
Synonym: Hexan-2-one
Tree Number: T6.2.20.8.1
database_cross_reference: LNC:LP18244-1
database_cross_reference: LNC:MTHU003736
database_cross_reference: MSH:D008742
database_cross_reference: NDFRT:N0000166799
database_cross_reference: RCD:X80Am
database_cross_reference: RCD:Xa0XE
database_cross_reference: SNM:E-5646
database_cross_reference: SNMI:C-21514
database_cross_reference: SNOMEDCT_US:259199008
database_cross_reference: SNOMEDCT_US:82026004

Ketone Bodies
type: Class
subclass of: Ketones
MCID: MC00007230
PMOID: PMO:00017143
Subclass_of: Ketones
Synonym: Bodies, Ketone
Synonym: Ketone Bodies [Chemical/Ingredient]
Synonym: Ketone bodies
Synonym: Ketone bodies (substance)
Synonym: Ketone body
Synonym: Ketone body (substance)
Synonym: Ketone body analyte
Synonym: bodies ketones
Synonym: body ketone
Synonym: body ketones
Tree Number: T6.2.20.9
database_cross_reference: CHV:0000007077
database_cross_reference: CSP:1675-7731
database_cross_reference: MSH:D007657
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000290
database_cross_reference: MTH:U000378
database_cross_reference: NDFRT:N0000008108
database_cross_reference: RCD:Xa7NS
database_cross_reference: SNM:F-11230
database_cross_reference: SNMI:F-61230
database_cross_reference: SNOMEDCT_US:76781009

Methadone
type: Class
subclass of: Ketones
MCID: MC00008157
PMOID: PMO:00017144
Subclass_of: Ketones
Synonym: (+-)-Methadone
Synonym: (+/-)-Methadone
Synonym: (Â±)-methadone
Synonym: 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-
Synonym: 6-Dimethylamino-4,4-diphenyl-3-heptanone
Synonym: Adolan
Synonym: Depridol
Synonym: Dolophine Hydrochloride
Synonym: Heptadon
Synonym: Heptanon
Tree Number: T6.2.20.11
database_cross_reference: AOD:0000007878
database_cross_reference: ATC:N07BC02
database_cross_reference: CCPSS:0014533
database_cross_reference: CHV:0000008022
database_cross_reference: CSP:2268-7060
database_cross_reference: DRUGBANK:DB00333
database_cross_reference: LNC:LP15015-8
database_cross_reference: LNC:MTHU001002
database_cross_reference: MEDLINEPLUS:4059
database_cross_reference: MMSL:d00050
database_cross_reference: MSH:D008691
database_cross_reference: MTH:U002072
database_cross_reference: MTHSPL:UC6VBE7V1Z
database_cross_reference: NCI:C62044
database_cross_reference: NCI_FDA:UC6VBE7V1Z
database_cross_reference: NDDF:004628
database_cross_reference: NDFRT:N0000006650
database_cross_reference: NDFRT:N0000147909
database_cross_reference: PSY:31080
database_cross_reference: RCD:x01KX
database_cross_reference: RXNORM:6813
database_cross_reference: SNM:E-7796
database_cross_reference: SNMI:C-606A0
database_cross_reference: SNOMEDCT_US:387286002
database_cross_reference: SNOMEDCT_US:51758009
database_cross_reference: USPMG:MTHU000008
database_cross_reference: VANDF:4019820

Methadyl Acetate
type: Class
subclass of: Methadone
MCID: MC00008158
PMOID: PMO:00017145
Subclass_of: Methadone
Synonym: 6-(Dimethylamino)-4,4-Diphenyl-3-Heptanol Acetate
Synonym: Acetilmetadol
Synonym: Acetylmethadol
Synonym: Acetylmethadolum
Synonym: Benzeneethanol, beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester)
Synonym: METHADYL ACETATE
Synonym: Methadyl Acetate [Chemical/Ingredient]
Synonym: Methadyl acetate
Synonym: acetylmethadol
Synonym: methadyl acetate
Tree Number: T6.2.20.11.1
database_cross_reference: CHV:0000008023
database_cross_reference: CSP:2268-7081
database_cross_reference: DRUGBANK:DB01433
database_cross_reference: LCH:U002932
database_cross_reference: LCH_NW:sh85084376
database_cross_reference: MSH:D008692
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91045
database_cross_reference: NCI_FDA:L59OC40KWJ
database_cross_reference: NDFRT:N0000006653
database_cross_reference: RXNORM:6814

Pentanones
type: Class
subclass of: Ketones
MCID: MC00009834
PMOID: PMO:00017146
Subclass_of: Ketones
Synonym: Pentanone
Synonym: Pentanone (substance)
Synonym: Pentanones [Chemical/Ingredient]
Tree Number: T6.2.20.12
database_cross_reference: MSH:D010422
database_cross_reference: NDFRT:N0000166795
database_cross_reference: RCD:Xa7No
database_cross_reference: SNMI:C-21501
database_cross_reference: SNOMEDCT_US:85462001

Phosgene
type: Class
subclass of: Ketones
MCID: MC00010091
PMOID: PMO:00017147
Subclass_of: Ketones
Synonym: Carbonic dichloride
Synonym: Carbonyl chloride
Synonym: Phosgene (substance)
Synonym: Phosgene [Chemical/Ingredient]
Synonym: phosgene
Synonym: phosgenes
Tree Number: T6.2.20.13
database_cross_reference: CHV:0000009650
database_cross_reference: LNC:LP34824-0
database_cross_reference: LNC:MTHU017632
database_cross_reference: MSH:D010705
database_cross_reference: NDFRT:N0000166796
database_cross_reference: RCD:X79CG
database_cross_reference: SNM:E-6631
database_cross_reference: SNMI:C-27301
database_cross_reference: SNOMEDCT_US:70221002

Propiophenones
type: Class
subclass of: Ketones
MCID: MC00010721
PMOID: PMO:00017148
Subclass_of: Ketones
Synonym: Propiophenones [Chemical/Ingredient]
Tree Number: T6.2.20.14
database_cross_reference: LCH_NW:sh2010003589
database_cross_reference: MSH:D011427
database_cross_reference: NDFRT:N0000007679

Hydroxypropiophenone
type: Class
subclass of: Propiophenones
MCID: MC00006512
PMOID: PMO:00017149
Subclass_of: Propiophenones
Synonym: 1-Propanone, 1-phenyl-, monohydroxy deriv.
Synonym: Hydroxypropiophenone [Chemical/Ingredient]
Tree Number: T6.2.20.14.1
database_cross_reference: MSH:D006910
database_cross_reference: NDFRT:N0000166787

Propafenone
type: Class
subclass of: Propiophenones
MCID: MC00010700
PMOID: PMO:00017150
Subclass_of: Propiophenones
Synonym: 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone
Synonym: 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-
Synonym: 2-(2'-Hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone
Synonym: Myl-propafenone
Synonym: Mylan-propafenone
Synonym: Nu-propafenone
Synonym: PMS-propafenone
Synonym: PROPAFENONE
Synonym: Propafenona
Synonym: Propafenone (product)
Tree Number: T6.2.20.14.4
database_cross_reference: ATC:C01BC03
database_cross_reference: CHV:0000010186
database_cross_reference: DRUGBANK:DB01182
database_cross_reference: LCH:U003856
database_cross_reference: LCH_NW:sh85107442
database_cross_reference: LNC:LP17241-8
database_cross_reference: LNC:MTHU012323
database_cross_reference: MMSL:40681
database_cross_reference: MMSL:d00358
database_cross_reference: MSH:D011405
database_cross_reference: MTHSPL:68IQX3T69U
database_cross_reference: NCI:C61909
database_cross_reference: NCI_FDA:68IQX3T69U
database_cross_reference: NDDF:004487
database_cross_reference: NDFRT:N0000006692
database_cross_reference: NDFRT:N0000147996
database_cross_reference: RCD:x01QN
database_cross_reference: RXNORM:8754
database_cross_reference: SNMI:C-804D0
database_cross_reference: SNOMEDCT_US:372910007
database_cross_reference: SNOMEDCT_US:96300001
database_cross_reference: USPMG:MTHU000907
database_cross_reference: VANDF:4019911

Tolperisone
type: Class
subclass of: Propiophenones
subclass of: Pyridines
MCID: MC00012902
PMOID: PMO:00017151
Subclass_of: Propiophenones
Subclass_of: Pyridines
Synonym: 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-
Synonym: TOLPERISONE
Synonym: Tolperisone (substance)
Synonym: Tolperisone [Chemical/Ingredient]
Synonym: tolperisone
Tree Number: T6.2.20.14.5
Tree Number: T6.3.5.20.26
database_cross_reference: ATC:M02AX06
database_cross_reference: ATC:M03BX04
database_cross_reference: CHV:0000012345
database_cross_reference: MSH:D014049
database_cross_reference: NCI:C84219
database_cross_reference: NCI_FDA:F5EOM0LD8E
database_cross_reference: NDDF:004185
database_cross_reference: NDFRT:N0000167236
database_cross_reference: RXNORM:10639
database_cross_reference: SNOMEDCT_US:703717006

Bupropion
type: Class
subclass of: Propiophenones
MCID: MC00043207
PMOID: PMO:00017152
Subclass_of: Propiophenones
Synonym: (+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
Synonym: 1-Propanone, 1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-
Synonym: 1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-
Synonym: Act Bupropion XL
Synonym: Amfebutamon
Synonym: Amfebutamone
Synonym: Aplenzin ER
Synonym: Appbutamone
Synonym: Appbutamone-D
Synonym: Ava-bupropion SR
Tree Number: T6.2.20.14.6
database_cross_reference: AOD:0000019121
database_cross_reference: ATC:N06AX12
database_cross_reference: CHV:0000015497
database_cross_reference: CSP:4008-0018
database_cross_reference: DRUGBANK:DB01156
database_cross_reference: LNC:LP17172-5
database_cross_reference: LNC:MTHU022987
database_cross_reference: MEDCIN:42337
database_cross_reference: MMSL:d00181
database_cross_reference: MSH:D016642
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:01ZG3TPX31
database_cross_reference: NCI:C1317
database_cross_reference: NCI:C62012
database_cross_reference: NCI_FDA:01ZG3TPX31
database_cross_reference: NCI_NCI-GLOSS:CDR0000045082
database_cross_reference: NDDF:004611
database_cross_reference: NDFRT:N0000006417
database_cross_reference: NDFRT:N0000147738
database_cross_reference: PDQ:CDR0000038567
database_cross_reference: PSY:07081
database_cross_reference: RXNORM:42347
database_cross_reference: SNMI:C-62160
database_cross_reference: SNOMEDCT_US:323344001
database_cross_reference: SNOMEDCT_US:387564004
database_cross_reference: SNOMEDCT_US:96199001
database_cross_reference: USPMG:MTHU000339
database_cross_reference: VANDF:4019645

Chalcones
type: Class
subclass of: Propiophenones
MCID: MC00002577
PMOID: PMO:00017153
Subclass_of: Propiophenones
Synonym: 1,3 Diphenyl 2 Propen 1 One
Synonym: 1,3-Diphenyl-2-Propen-1-One
Synonym: 2-Propen-1-one, 1,3-diphenyl-
Synonym: Benzalacetophenone
Synonym: Benzylideneacetophenone
Synonym: Chalcone
Synonym: Chalcone [Chemical/Ingredient]
Synonym: Chalkone
Synonym: chalcone
Synonym: chalcones
Tree Number: T6.2.20.14.7
database_cross_reference: CHV:0000002715
database_cross_reference: MSH:D002599
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008050

Lactones
type: Class
subclass of: Organic Chemicals
MCID: MC00007337
PMOID: PMO:00017155
Subclass_of: Organic Chemicals
Synonym: LACTONE
Synonym: Lactone
Synonym: Lactone (substance)
Synonym: Lactone Compound
Synonym: Lactones [Chemical/Ingredient]
Synonym: lactone
Synonym: lactones
Tree Number: T6.2.21
database_cross_reference: CHV:0000007189
database_cross_reference: CSP:2188-5358
database_cross_reference: LCH:U002609
database_cross_reference: LCH_NW:sh85073870
database_cross_reference: MSH:D007783
database_cross_reference: NCI:C606
database_cross_reference: NCI_DTP:NSC0071047
database_cross_reference: NDFRT:N0000007646
database_cross_reference: SNOMEDCT_US:419190006

Propiolactone
type: Class
subclass of: Lactones
MCID: MC00010717
PMOID: PMO:00017156
Subclass_of: Lactones
Synonym: 2-Oxetanone
Synonym: 3-Hydroxypropionic Acid, b-Lactone
Synonym: 3-Propanolide
Synonym: 3-Propiolactone
Synonym: Beta-Propiolactone
Synonym: Beta-propiolactone
Synonym: Hydracrylic Acid, b-Lactone
Synonym: Oxetanone
Synonym: PROPIOLACTONE
Synonym: Propanolide
Tree Number: T6.2.21.3
database_cross_reference: CHV:0000010197
database_cross_reference: CSP:2188-5358
database_cross_reference: DRUGBANK:DB09348
database_cross_reference: LNC:LP34827-3
database_cross_reference: LNC:MTHU017636
database_cross_reference: MEDCIN:257667
database_cross_reference: MSH:D011420
database_cross_reference: NCI:C44339
database_cross_reference: NCI_FDA:6RC3ZT4HB0
database_cross_reference: NDDF:012821
database_cross_reference: NDFRT:N0000166850
database_cross_reference: RXNORM:1311565
database_cross_reference: SNM:E-6951
database_cross_reference: SNMI:C-29061
database_cross_reference: SNOMEDCT_US:2405001

Spironolactone
type: Class
subclass of: Lactones
MCID: MC00012146
PMOID: PMO:00017157
Subclass_of: Lactones
Synonym: 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate
Synonym: Aldactazide 25
Synonym: Aldactazide 50
Synonym: Aldactone 100 mg
Synonym: Aldactone 25 mg
Synonym: Apo-spirozide Tab
Synonym: CaroSpir
Synonym: Espironolactona
Synonym: Ntp-spironolactone
Synonym: Osyrol
Tree Number: T6.2.21.4
database_cross_reference: AOD:0000018722
database_cross_reference: ATC:C03DA01
database_cross_reference: CHV:0000011637
database_cross_reference: CSP:2794-2536
database_cross_reference: DRUGBANK:DB00421
database_cross_reference: LCH:U004438
database_cross_reference: LCH_NW:sh85126790
database_cross_reference: LNC:LP16280-7
database_cross_reference: LNC:MTHU003227
database_cross_reference: MEDCIN:40614
database_cross_reference: MMSL:1587
database_cross_reference: MMSL:5506
database_cross_reference: MMSL:d00373
database_cross_reference: MSH:D013148
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:27O7W4T232
database_cross_reference: NCI:C840
database_cross_reference: NCI_DCP:07605
database_cross_reference: NCI_DTP:NSC0150399
database_cross_reference: NCI_FDA:27O7W4T232
database_cross_reference: NDDF:002211
database_cross_reference: NDFRT:N0000005900
database_cross_reference: NDFRT:N0000146234
database_cross_reference: PDQ:CDR0000039444
database_cross_reference: RCD:b43..
database_cross_reference: RXNORM:9997
database_cross_reference: SNM:E-8914
database_cross_reference: SNMI:C-72420
database_cross_reference: SNOMEDCT_US:13929005
database_cross_reference: SNOMEDCT_US:387078006
database_cross_reference: USPMG:MTHU001018
database_cross_reference: VANDF:4017881

Venturicidins
type: Class
subclass of: Lactones
MCID: MC00013527
PMOID: PMO:00017158
Subclass_of: Lactones
Synonym: Venturicidins [Chemical/Ingredient]
Tree Number: T6.2.21.5
database_cross_reference: MSH:D014698
database_cross_reference: NDFRT:N0000166851

4-Butyrolactone
type: Class
subclass of: Lactones
subclass of: Furans
MCID: MC00000074
PMOID: PMO:00017159
Subclass_of: Furans
Subclass_of: Lactones
Synonym: 1,4 Butanolide
Synonym: 1,4-Butanolide
Synonym: 1,4-Lactone
Synonym: 2(3H)-Furanone, dihydro-
Synonym: 4 Butyrolactone
Synonym: 4 Hydroxybutyric Acid Lactone
Synonym: 4-Butyrolactone [Chemical/Ingredient]
Synonym: 4-Hydroxybutyric Acid Lactone
Synonym: 4-Hydroxybutyric acid lactone
Synonym: BUTANOLIDE 01 04
Tree Number: T6.2.21.7
Tree Number: T6.3.5.10.11
database_cross_reference: CHV:0000000513
database_cross_reference: DRUGBANK:DB04699
database_cross_reference: MSH:D015107
database_cross_reference: NDFRT:N0000167129

Macrolides
type: Class
subclass of: Lactones
subclass of: Polyketides
MCID: MC00098995
PMOID: PMO:00017160
Subclass_of: Lactones
Subclass_of: Polyketides
Synonym: Macrolide
Synonym: Macrolide (substance)
Synonym: Macrolides [Chemical/Ingredient]
Synonym: macrolide
Synonym: macrolides
Tree Number: T6.2.21.11.1
Tree Number: T6.2.21.8
Tree Number: T6.4.5.10.1
database_cross_reference: CHV:0000027647
database_cross_reference: MSH:D018942
database_cross_reference: MTH:U002420
database_cross_reference: NCI:C67445
database_cross_reference: NDFRT:N0000007529
database_cross_reference: SNOMEDCT_US:428787002

Lucensomycin
type: Class
subclass of: Macrolides
MCID: MC00007690
PMOID: PMO:00017161
Subclass_of: Macrolides
Synonym: Lucensomycin [Chemical/Ingredient]
Synonym: Lucimycin
Tree Number: T6.2.21.8.1
database_cross_reference: MSH:D008155
database_cross_reference: NDFRT:N0000168431

Maytansine
type: Class
subclass of: Lactams, Macrocyclic
subclass of: Macrolides
MCID: MC00007938
PMOID: PMO:00017162
Subclass_of: Lactams, Macrocyclic
Subclass_of: Macrolides
Synonym: Alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9, 22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dione
Synonym: L-Alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8, 23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*, 3R*,5R*,6R*,16E,18E,20S*,21R*)]-
Synonym: L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]
Synonym: MAYTANSINE
Synonym: Maitansine
Synonym: Maysanine
Synonym: Maytansin
Synonym: Maytansine [Chemical/Ingredient]
Synonym: alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dione
Synonym: maitansine
Tree Number: T6.2.21.8.2
Tree Number: T6.4.5.7.1
database_cross_reference: CSP:0192-4208
database_cross_reference: CSP:0200-5669
database_cross_reference: MSH:D008453
database_cross_reference: NCI:C626
database_cross_reference: NCI_DTP:NSC0153858
database_cross_reference: NCI_FDA:14083FR882
database_cross_reference: NDFRT:N0000168425
database_cross_reference: PDQ:CDR0000039492

Nystatin
type: Class
subclass of: Macrolides
MCID: MC00009079
PMOID: PMO:00017163
Subclass_of: Macrolides
Synonym: Adiclair
Synonym: Afunginal
Synonym: Biofanal
Synonym: Candacide
Synonym: Candermil
Synonym: Candidias
Synonym: Candistat
Synonym: Candistatin Topical Powder - 100000 Unit/g
Synonym: Candistin
Synonym: Canstat
Tree Number: T6.2.21.8.4
database_cross_reference: AOD:0000019201
database_cross_reference: ATC:A07AA02
database_cross_reference: ATC:D01AA01
database_cross_reference: ATC:G01AA01
database_cross_reference: CHV:0000008858
database_cross_reference: CHV:0000051771
database_cross_reference: CSP:0203-7824
database_cross_reference: DRUGBANK:DB00646
database_cross_reference: LCH:U003311
database_cross_reference: LCH_NW:sh85089200
database_cross_reference: LNC:LP14829-3
database_cross_reference: LNC:MTHU002047
database_cross_reference: MEDCIN:41450
database_cross_reference: MMSL:2828
database_cross_reference: MMSL:29922
database_cross_reference: MMSL:5194
database_cross_reference: MMSL:d01233
database_cross_reference: MSH:D009761
database_cross_reference: MTHSPL:BDF1O1C72E
database_cross_reference: NCI:C710
database_cross_reference: NCI_DTP:NSC0150817
database_cross_reference: NCI_FDA:BDF1O1C72E
database_cross_reference: NCI_NCI-GLOSS:CDR0000045229
database_cross_reference: NDDF:002889
database_cross_reference: NDFRT:N0000006699
database_cross_reference: NDFRT:N0000145961
database_cross_reference: PDQ:CDR0000039512
database_cross_reference: RCD:eh7..
database_cross_reference: RCD:g48..
database_cross_reference: RCD:lc6..
database_cross_reference: RCD:mea..
database_cross_reference: RCD:x02M0
database_cross_reference: RCDAE:g48..
database_cross_reference: RXNORM:7597
database_cross_reference: SNM:E-7301
database_cross_reference: SNMI:C-52B70
database_cross_reference: SNOMEDCT_US:12096000
database_cross_reference: SNOMEDCT_US:324688006
database_cross_reference: SNOMEDCT_US:326264001
database_cross_reference: SNOMEDCT_US:331210006
database_cross_reference: SNOMEDCT_US:332925001
database_cross_reference: SNOMEDCT_US:387048002
database_cross_reference: USPMG:MTHU000402
database_cross_reference: VANDF:4017580

Oleandomycin
type: Class
subclass of: Macrolides
MCID: MC00009131
PMOID: PMO:00017164
Subclass_of: Macrolides
Synonym: OLEANDOMYCIN
Synonym: Oleandomycin (substance)
Synonym: Oleandomycin - chemical
Synonym: Oleandomycin - chemical (substance)
Synonym: Oleandomycin [Chemical/Ingredient]
Synonym: oleandomycin
Tree Number: T6.2.21.8.5
database_cross_reference: ATC:J01FA05
database_cross_reference: LNC:LP16195-7
database_cross_reference: LNC:MTHU008464
database_cross_reference: MSH:D009827
database_cross_reference: NCI:C61864
database_cross_reference: NCI_FDA:P8ZQ646136
database_cross_reference: NDDF:002764
database_cross_reference: NDFRT:N0000007496
database_cross_reference: RXNORM:7629
database_cross_reference: SNMI:C-522B9
database_cross_reference: SNOMEDCT_US:360203001
database_cross_reference: SNOMEDCT_US:41332001

Oligomycins
type: Class
subclass of: Macrolides
MCID: MC00009146
PMOID: PMO:00017166
Subclass_of: Macrolides
Synonym: Oligomycin
Synonym: Oligomycins [Chemical/Ingredient]
Synonym: oligomycin
Tree Number: T6.2.21.8.6
database_cross_reference: AOD:0000018615
database_cross_reference: CSP:0204-1570
database_cross_reference: MSH:D009840
database_cross_reference: NDFRT:N0000168432

Natamycin
type: Class
subclass of: Macrolides
MCID: MC00008682
PMOID: PMO:00017168
Subclass_of: Macrolides
Synonym: 16-(3-Amino-3,6-didesoxy-beta-D-mannopyranosyloxy)-5,6-epoxy-8,12,14-trihydroxy-26-methyl-2,10-dioxo-1-oxacyclohexacosa-3,17,19,21,23-pentaen-13-carbonsaeure
Synonym: Delvocid
Synonym: Delvolan
Synonym: Fukricin
Synonym: InfectoMyk
Synonym: N-Mycin
Synonym: NATAMYCIN
Synonym: Natadrops
Synonym: Natamet
Synonym: Natamicina
Tree Number: T6.2.21.8.7
database_cross_reference: ATC:A01AB10
database_cross_reference: ATC:A07AA03
database_cross_reference: ATC:D01AA02
database_cross_reference: ATC:G01AA02
database_cross_reference: ATC:S01AA10
database_cross_reference: CHV:0000008505
database_cross_reference: DRUGBANK:DB00826
database_cross_reference: LNC:LP30647-9
database_cross_reference: LNC:MTHU015102
database_cross_reference: MEDCIN:257645
database_cross_reference: MMSL:5158
database_cross_reference: MMSL:d01213
database_cross_reference: MSH:D010866
database_cross_reference: MTHSPL:8O0C852CPO
database_cross_reference: NCI:C47634
database_cross_reference: NCI_FDA:8O0C852CPO
database_cross_reference: NDDF:002891
database_cross_reference: NDFRT:N0000006113
database_cross_reference: NDFRT:N0000146913
database_cross_reference: RCD:eh6..
database_cross_reference: RCD:g47..
database_cross_reference: RCD:lc5..
database_cross_reference: RCD:me8..
database_cross_reference: RCD:x02Lz
database_cross_reference: RCDAE:g47..
database_cross_reference: RXNORM:7268
database_cross_reference: SNMI:C-96550
database_cross_reference: SNOMEDCT_US:324685009
database_cross_reference: SNOMEDCT_US:326259000
database_cross_reference: SNOMEDCT_US:331204006
database_cross_reference: SNOMEDCT_US:332920006
database_cross_reference: SNOMEDCT_US:34462007
database_cross_reference: SNOMEDCT_US:372712006
database_cross_reference: USPMG:MTHU001550
database_cross_reference: VANDF:4018597

Miocamycin
type: Class
subclass of: Macrolides
MCID: MC00008333
PMOID: PMO:00017169
Subclass_of: Macrolides
Synonym: 9,3'' Di O Acetylmidecamycin
Synonym: 9,3'' Diacetylmidecamycin
Synonym: 9,3''-Di-O-Acetylmidecamycin
Synonym: 9,3''-Diacetylmidecamycin
Synonym: Leucomycin V, 3B,9-diacetate 3,4B-dipropanoate
Synonym: Miocamycin [Chemical/Ingredient]
Synonym: Miocamycine
Synonym: Miokamycin
Synonym: Miokamycin (substance)
Synonym: Myocamicin
Tree Number: T6.2.21.8.8
database_cross_reference: ATC:J01FA11
database_cross_reference: CHV:0000008170
database_cross_reference: LNC:LP16045-4
database_cross_reference: LNC:MTHU008457
database_cross_reference: MEDCIN:197375
database_cross_reference: MSH:D015644
database_cross_reference: NDDF:004200
database_cross_reference: NDFRT:N0000168430
database_cross_reference: RXNORM:6985
database_cross_reference: SNMI:C-52A40
database_cross_reference: SNOMEDCT_US:96036008

Tylosin
type: Class
subclass of: Macrolides
MCID: MC00013250
PMOID: PMO:00017170
Subclass_of: Macrolides
Synonym: Fradizine
Synonym: TYLOSIN
Synonym: Tylosin (product)
Synonym: Tylosin (substance)
Synonym: Tylosin [Chemical/Ingredient]
Synonym: Tylosine
Synonym: [(2R,3R,4E,6E,9R,11R,12S,13S,14R) -12- {[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl) -3- (dimethylamino)-beta-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5, 9,13-trimethyl-8, 16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-beta-D-allopyranoside
Synonym: tylosin
Synonym: tylosine
Tree Number: T6.2.21.8.9
database_cross_reference: CHV:0000012677
database_cross_reference: LNC:LP33368-9
database_cross_reference: LNC:MTHU016685
database_cross_reference: MSH:D015645
database_cross_reference: MTHSPL:YEF4JXN031
database_cross_reference: NCI:C84234
database_cross_reference: NCI_FDA:YEF4JXN031
database_cross_reference: NDFRT:N0000168424
database_cross_reference: RXNORM:995505
database_cross_reference: SNMI:C-52340
database_cross_reference: SNOMEDCT_US:373553006
database_cross_reference: SNOMEDCT_US:96020006

Tacrolimus
type: Class
subclass of: Macrolides
MCID: MC00043171
PMOID: PMO:00017171
Subclass_of: Macrolides
Synonym: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-p
Synonym: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-
Synonym: Fujimycin
Synonym: Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
Synonym: TACROLIMUS
Synonym: Tacrolimus (product)
Synonym: Tacrolimus (substance)
Synonym: Tacrolimus [Chemical/Ingredient]
Synonym: Tacrolimus [skin]
Synonym: Tacrolimus [skin] (product)
Tree Number: T6.2.21.8.10
database_cross_reference: ATC:D11AH01
database_cross_reference: ATC:L04AD02
database_cross_reference: CHV:0000015463
database_cross_reference: CSP:4004-0005
database_cross_reference: DRUGBANK:DB00864
database_cross_reference: LNC:LP15182-6
database_cross_reference: LNC:MTHU001849
database_cross_reference: MEDCIN:340483
database_cross_reference: MMSL:230894
database_cross_reference: MMSL:5539
database_cross_reference: MMSL:66434
database_cross_reference: MMSL:d03752
database_cross_reference: MSH:D016559
database_cross_reference: MTH:U002385
database_cross_reference: MTHSPL:WM0HAQ4WNM
database_cross_reference: NCI:C1311
database_cross_reference: NCI_DCP:01195
database_cross_reference: NCI_DTP:NSC0717865
database_cross_reference: NCI_FDA:WM0HAQ4WNM
database_cross_reference: NCI_NCI-GLOSS:CDR0000045414
database_cross_reference: NDDF:004446
database_cross_reference: NDFRT:N0000007302
database_cross_reference: NDFRT:N0000148372
database_cross_reference: PDQ:CDR0000042009
database_cross_reference: RCD:h83..
database_cross_reference: RXNORM:42316
database_cross_reference: SNOMEDCT_US:109129008
database_cross_reference: SNOMEDCT_US:386975001
database_cross_reference: SNOMEDCT_US:395305001
database_cross_reference: USPMG:MTHU001504
database_cross_reference: VANDF:4020868

Sirolimus
type: Class
subclass of: Macrolides
MCID: MC00036574
PMOID: PMO:00017172
Subclass_of: Macrolides
Synonym: (-)-Rapamycin
Synonym: Gd-sirolimus
Synonym: RAPA
Synonym: RAPAMYCIN
Synonym: Rapamune Oral Solution
Synonym: Rapamycin
Synonym: SIROLIMUS
Synonym: SLM
Synonym: Sirolimus (product)
Tree Number: T6.2.21.8.11
database_cross_reference: ATC:L04AA10
database_cross_reference: ATC:S01XA23
database_cross_reference: CHV:0000014738
database_cross_reference: CSP:4005-0055
database_cross_reference: DRUGBANK:DB00877
database_cross_reference: LCH_NW:sh2001005861
database_cross_reference: LNC:LP21368-3
database_cross_reference: LNC:MTHU013897
database_cross_reference: MEDCIN:257673
database_cross_reference: MMSL:210889
database_cross_reference: MMSL:8303
database_cross_reference: MMSL:d04453
database_cross_reference: MSH:D020123
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:W36ZG6FT64
database_cross_reference: NCI:C1212
database_cross_reference: NCI_DCP:20504
database_cross_reference: NCI_DTP:NSC0226080
database_cross_reference: NCI_FDA:W36ZG6FT64
database_cross_reference: NCI_NCI-GLOSS:CDR0000045513
database_cross_reference: NCI_NCI-GLOSS:CDR0000285947
database_cross_reference: NDDF:007885
database_cross_reference: NDFRT:N0000006605
database_cross_reference: NDFRT:N0000148624
database_cross_reference: PDQ:CDR0000042555
database_cross_reference: RXNORM:35302
database_cross_reference: SNOMEDCT_US:116109004
database_cross_reference: SNOMEDCT_US:387014003
database_cross_reference: USPMG:MTHU001503
database_cross_reference: VANDF:4021176

Acyl-Butyrolactones
type: Class
subclass of: Lactones
MCID: MC00628797
PMOID: PMO:00017174
Subclass_of: Lactones
Synonym: Acyl Butyrolactones
Synonym: Acyl-Butyrolactones [Chemical/Ingredient]
Tree Number: T6.2.21.10
database_cross_reference: MSH:D054742
database_cross_reference: NDFRT:N0000178793

Polyketides
type: Class
subclass of: Lactones
subclass of: Macrocyclic Compounds
MCID: MC00831126
PMOID: PMO:00017175
Subclass_of: Lactones
Subclass_of: Macrocyclic Compounds
Synonym: Polyketides [Chemical/Ingredient]
Tree Number: T6.2.21.11
Tree Number: T6.4.5.10
database_cross_reference: LCH_NW:sh85104652
database_cross_reference: MSH:D061065
database_cross_reference: NDFRT:N0000183542

Nicorandil
type: Class
subclass of: Nitrates
MCID: MC00033187
PMOID: PMO:00017194
Subclass_of: Nitrates
Synonym: 2 Nicotinamidethyl Nitrate
Synonym: 2 Nicotinamidoethyl Nitrate
Synonym: 2-Nicotinamidethyl Nitrate
Synonym: 2-Nicotinamidoethyl Nitrate
Synonym: 2-Nicotinamidoethyl nitrate
Synonym: 3-Pyridinecarboxamide, N-(2-(Nitroxy)ethyl)-
Synonym: Angedil
Synonym: Angicor
Synonym: Aprior
Synonym: Av-Cor
Tree Number: T6.2.22.2
database_cross_reference: ATC:C01DX16
database_cross_reference: CHV:0000014493
database_cross_reference: DRUGBANK:DB09220
database_cross_reference: MEDCIN:305544
database_cross_reference: MSH:D020108
database_cross_reference: NCI:C84012
database_cross_reference: NCI_FDA:260456HAM0
database_cross_reference: NDDF:005831
database_cross_reference: NDFRT:N0000167327
database_cross_reference: RCD:blf..
database_cross_reference: RXNORM:31748
database_cross_reference: SNOMEDCT_US:319304004
database_cross_reference: SNOMEDCT_US:395809002

Nitriles
type: Class
subclass of: Organic Chemicals
MCID: MC00008923
PMOID: PMO:00017195
Subclass_of: Organic Chemicals
Synonym: NITRILE
Synonym: Nitrile
Synonym: Nitrile (substance)
Synonym: Nitriles [Chemical/Ingredient]
Synonym: nitrile
Synonym: nitriles
Tree Number: T6.2.23
database_cross_reference: AOD:0000020011
database_cross_reference: CHV:0000008734
database_cross_reference: CSP:0774-4855
database_cross_reference: LCH:U003241
database_cross_reference: LCH_NW:sh85092054
database_cross_reference: MSH:D009570
database_cross_reference: NCI:C696
database_cross_reference: NDDF:011268
database_cross_reference: NDFRT:N0000006620
database_cross_reference: NDFRT:N0000184205
database_cross_reference: RCD:Xa7Pb
database_cross_reference: SNOMEDCT_US:300066007
database_cross_reference: VANDF:4021188

Rilpivirine
type: Class
subclass of: Nitriles
subclass of: Pyrimidines
MCID: MC00542566
PMOID: PMO:00017196
Subclass_of: Nitriles
Subclass_of: Pyrimidines
Synonym: 4-((4-((4-((1E)-2-Cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile
Synonym: 4-{[4-({4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
Synonym: RILPIVIRINE
Synonym: Rilpivirine (product)
Synonym: Rilpivirine (substance)
Synonym: Rilpivirine [Chemical/Ingredient]
Synonym: antiviral rilpivirine
Synonym: rilpivirine
Synonym: rilpivirine (medication)
Tree Number: T6.2.23.1
Tree Number: T6.3.5.21.1
database_cross_reference: ATC:J05AG05
database_cross_reference: DRUGBANK:DB08864
database_cross_reference: LNC:LP135443-2
database_cross_reference: LNC:MTHU042155
database_cross_reference: MEDCIN:309423
database_cross_reference: MMSL:27887
database_cross_reference: MMSL:d07776
database_cross_reference: MSH:D000068696
database_cross_reference: MTHSPL:FI96A8X663
database_cross_reference: NCI:C76929
database_cross_reference: NCI_FDA:FI96A8X663
database_cross_reference: NDDF:013795
database_cross_reference: NDFRT:N0000182740
database_cross_reference: NDFRT:N0000191954
database_cross_reference: RXNORM:1102270
database_cross_reference: SNOMEDCT_US:703123005
database_cross_reference: SNOMEDCT_US:703777002
database_cross_reference: USPMG:MTHU002683
database_cross_reference: VANDF:4030730

Emtricitabine, Rilpivirine, Tenofovir Drug Combination
type: Class
subclass of: Rilpivirine
subclass of: PMO:00024461
MCID: MC01007817
PMOID: PMO:00017197
Subclass_of: Drug Combinations
Subclass_of: Rilpivirine
Synonym: Combination, Emtricitabine-Rilpivirine-Tenofovir Drug
Synonym: Drug Combination, Emtricitabine-Rilpivirine-Tenofovir
Synonym: Emtricitabine Rilpivirine Tenofovir Drug Combination
Synonym: Emtricitabine, Rilpivirine, Tenofovir Drug Combination [Chemical/Ingredient]
Synonym: Emtricitabine-Rilpivirine-Tenofovir Drug Combination
Tree Number: T6.15.3.7
Tree Number: T6.2.23.1.1
database_cross_reference: MSH:D000068678
database_cross_reference: NDFRT:N0000192007

Acetonitriles
type: Class
subclass of: Nitriles
MCID: MC00000191
PMOID: PMO:00017198
Subclass_of: Nitriles
Synonym: Acetonitriles [Chemical/Ingredient]
Synonym: Cyanides, Methyl
Synonym: Cyanomethanes
Synonym: Ethane Nitriles
Synonym: Methyl Cyanides
Synonym: Nitriles, Ethane
Tree Number: T6.2.23.2
database_cross_reference: MSH:D000097
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166567

Aminoacetonitrile
type: Class
subclass of: Acetonitriles
MCID: MC00000749
PMOID: PMO:00017199
Subclass_of: Acetonitriles
Synonym: Acetonitrile, amino-
Synonym: Aminoacetonitrile [Chemical/Ingredient]
Synonym: Cyanomethylamine
Synonym: Glycinonitrile
Tree Number: T6.2.23.2.1
database_cross_reference: LCH:U000196
database_cross_reference: LCH_NW:sh85004496
database_cross_reference: MSH:D000607
database_cross_reference: NDFRT:N0000166568

Acrylonitrile
type: Class
subclass of: Nitriles
MCID: MC00000283
PMOID: PMO:00017200
Subclass_of: Nitriles
Synonym: 2-Propenenitrile
Synonym: ACRYLONITRILE
Synonym: Acrylonitrile (substance)
Synonym: Acrylonitrile [Chemical/Ingredient]
Synonym: Cyanide, Vinyl
Synonym: Cyanoethylene
Synonym: Vinyl Cyanide
Synonym: Vinyl cyanide
Synonym: Vinylcyanide
Synonym: acrylonitrile
Tree Number: T6.2.23.3
database_cross_reference: CHV:0000000664
database_cross_reference: LCH:U000047
database_cross_reference: LCH_NW:sh87000843
database_cross_reference: LNC:LP16799-6
database_cross_reference: LNC:MTHU017554
database_cross_reference: MSH:D000181
database_cross_reference: NCI:C28130
database_cross_reference: NCI_FDA:MP1U0D42PE
database_cross_reference: NCI_NCI-GLOSS:CDR0000269435
database_cross_reference: NDFRT:N0000166571
database_cross_reference: RCD:X808r
database_cross_reference: SNM:E-5767
database_cross_reference: SNMI:C-2A110
database_cross_reference: SNOMEDCT_US:62915004

Aminopropionitrile
type: Class
subclass of: Nitriles
MCID: MC00000771
PMOID: PMO:00017201
Subclass_of: Nitriles
Synonym: 3-AMINOPROPANENITRILE
Synonym: 3-Aminopropanenitrile
Synonym: 3-Aminopropionitrile
Synonym: Aminopropionitrile [Chemical/Ingredient]
Synonym: BAPN
Synonym: Beta-Aminopropionitrile
Synonym: Propanenitrile, 3-amino-
Synonym: beta Aminopropionitrile
Synonym: beta aminopropionitrile
Synonym: beta-Aminopropionitrile
Tree Number: T6.2.23.4
database_cross_reference: CSP:0774-5678
database_cross_reference: MSH:D000629
database_cross_reference: NCI:C83513
database_cross_reference: NCI_FDA:38D5LJ4KH2
database_cross_reference: NDFRT:N0000166569
database_cross_reference: SNMI:C-30213
database_cross_reference: SNOMEDCT_US:55583004

Amygdalin
type: Class
subclass of: Nitriles
subclass of: PMO:00020974
MCID: MC00000826
PMOID: PMO:00017202
Subclass_of: Glucosides
Subclass_of: Nitriles
Synonym: AMYGDALIN
Synonym: Amygdalin (substance)
Synonym: Amygdalin [Chemical/Ingredient]
Synonym: Amygdaloside
Synonym: Benzeneacetonitrile, alpha-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-, (R)-
Synonym: D(-)-Mandelonitrile-beta-D-gentiobioside
Synonym: MANDELONITRILE GENTIOBIOSIDE BETA
Synonym: Mandelonitrile beta Gentiobioside
Synonym: Mandelonitrile-beta-Gentiobioside
Synonym: Neoamygdalin
Tree Number: T6.2.23.5
Tree Number: T6.8.6.7.2
database_cross_reference: MSH:D000678
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:214UUQ9N0H
database_cross_reference: NCI:C28801
database_cross_reference: NCI_FDA:214UUQ9N0H
database_cross_reference: NCI_NCI-GLOSS:CDR0000454511
database_cross_reference: NDFRT:N0000168440
database_cross_reference: RXNORM:1371051
database_cross_reference: SNMI:C-30101
database_cross_reference: SNOMEDCT_US:77683008

o-Chlorobenzylidenemalonitrile
type: Class
subclass of: Nitriles
MCID: MC00009083
PMOID: PMO:00017203
Subclass_of: Nitriles
Synonym: 2 Chlorobenzylidene Malonitrile
Synonym: 2 Chlorobenzylidenemalonitrile
Synonym: 2-Chlorobenzylidene Malonitrile
Synonym: 2-Chlorobenzylidenemalonitrile
Synonym: CHLOROBENZYLIDENE MALONITRILE O
Synonym: CHLOROBENZYLIDENEMALONITRILE O
Synonym: CS Tear Gas
Synonym: Malonitrile, 2-Chlorobenzylidene
Synonym: Malonitrile, o-Chlorobenzylidene
Synonym: Malonitrile, ortho-Chlorobenzylidene
Tree Number: T6.2.23.9
database_cross_reference: MSH:D009763
database_cross_reference: NDFRT:N0000166570

Pregnenolone Carbonitrile
type: Class
subclass of: Nitriles
MCID: MC00010597
PMOID: PMO:00017204
Subclass_of: Nitriles
Synonym: 16 alpha-Carbonitrile, Pregnenolone
Synonym: Carbonitrile, Pregnenolone
Synonym: PCN
Synonym: Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3beta,16alpha)-
Synonym: Pregnenolone 16 alpha Carbonitrile
Synonym: Pregnenolone 16 alpha-Carbonitrile
Synonym: Pregnenolone Carbonitrile [Chemical/Ingredient]
Tree Number: T6.2.23.10
database_cross_reference: MSH:D011285
database_cross_reference: MTH:U002187
database_cross_reference: NDFRT:N0000167420

Technetium Tc 99m Sestamibi
type: Class
subclass of: Nitriles
subclass of: Organotechnetium Compounds
MCID: MC00063364
PMOID: PMO:00017205
Subclass_of: Nitriles
Subclass_of: Organotechnetium Compounds
Synonym: 99m Tc-sestamibi
Synonym: 99m-Tc sestamibi
Synonym: 99mTc Hexamibi
Synonym: 99mTc Sestamibi
Synonym: 99mTc sestamibi
Synonym: 99mTc-Hexamibi
Synonym: 99mTc-Sestamibi
Synonym: 99mTc-sestamibi
Synonym: 99mtc sestamibi
Synonym: 99mtc-sestamibi
Tree Number: T6.2.23.12
Tree Number: T6.2.28.13.4
database_cross_reference: ATC:V09GA01
database_cross_reference: CHV:0000017944
database_cross_reference: DRUGBANK:DB09161
database_cross_reference: LNC:LP208666-0
database_cross_reference: LNC:LP70300-6
database_cross_reference: MSH:D017256
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:971Z4W1S09
database_cross_reference: NCI:C1419
database_cross_reference: NCI_FDA:971Z4W1S09
database_cross_reference: NDFRT:N0000166769
database_cross_reference: NDFRT:N0000181530
database_cross_reference: PDQ:CDR0000037878
database_cross_reference: RXNORM:1482913
database_cross_reference: SNOMEDCT_US:424299003
database_cross_reference: VANDF:4030044

Fadrozole
type: Class
subclass of: Nitriles
MCID: MC00050301
PMOID: PMO:00017206
Subclass_of: Nitriles
Synonym: Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo(1,5-a)pyridin-5-yl)-
Synonym: FADROZOLE
Synonym: Fadrozole [Chemical/Ingredient]
Tree Number: T6.2.23.13
database_cross_reference: MSH:D017316
database_cross_reference: NCI:C79911
database_cross_reference: NCI_FDA:H3988M64PU
database_cross_reference: NDFRT:N0000167063

Amyl Nitrite
type: Class
subclass of: Nitrites
MCID: MC00000829
PMOID: PMO:00017207
Subclass_of: Nitrites
Synonym: 1-nitropentane
Synonym: AMYL NITRITE
Synonym: Amyl Nitrite Vitrellae Bpc Liq 0.33 Ml/cap
Synonym: Amyl Nitrite [Chemical/Ingredient]
Synonym: Amyl Nitrosum
Synonym: Amyl nitrite
Synonym: Amyl nitrite (product)
Synonym: Amyl nitrite (substance)
Synonym: Amylnitrite Glass Cap 5min
Synonym: Aspiral
Tree Number: T6.2.24.1
database_cross_reference: AOD:0000019615
database_cross_reference: ATC:V03AB22
database_cross_reference: CHV:0000001066
database_cross_reference: CSP:2073-7856
database_cross_reference: DRUGBANK:DB01612
database_cross_reference: LNC:LP18133-6
database_cross_reference: LNC:MTHU003452
database_cross_reference: MMSL:3836
database_cross_reference: MMSL:4197
database_cross_reference: MMSL:d00666
database_cross_reference: MSH:D000680
database_cross_reference: MTHSPL:22T8Z09XAK
database_cross_reference: NCI:C87278
database_cross_reference: NCI_FDA:22T8Z09XAK
database_cross_reference: NDDF:000684
database_cross_reference: NDFRT:N0000005927
database_cross_reference: NDFRT:N0000145899
database_cross_reference: RCD:as4..
database_cross_reference: RXNORM:742
database_cross_reference: SNM:E-7703
database_cross_reference: SNMI:C-81530
database_cross_reference: SNOMEDCT_US:116655003
database_cross_reference: SNOMEDCT_US:387038004
database_cross_reference: SNOMEDCT_US:41153003
database_cross_reference: VANDF:4017514

Nitro Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00008927
PMOID: PMO:00017208
Subclass_of: Organic Chemicals
Synonym: NITRO CPDS
Synonym: Nitro Compounds [Chemical/Ingredient]
Synonym: Nitro compounds
Synonym: nitro compound
Tree Number: T6.2.25
database_cross_reference: CSP:2079-0300
database_cross_reference: LCH:U003244
database_cross_reference: LCH_NW:sh85092057
database_cross_reference: MSH:D009574
database_cross_reference: NDFRT:N0000008159

Nitroglycerin
type: Class
subclass of: Nitro Compounds
MCID: MC00005731
PMOID: PMO:00017209
Subclass_of: Nitro Compounds
Synonym: 1,2,3-Propanetriol, trinitrate
Synonym: 1,2,3-Propanetrioltrinitrate
Synonym: 1,2,3-Propanetriyl nitrate
Synonym: 1,2,3-propanetriol trinitrate
Synonym: Apo-nitroglycerin
Synonym: Dermatrans
Synonym: GTN - Glyceryl trinitrate
Synonym: Gen-Nitro
Synonym: Glycerin trinitrate
Synonym: Glycerol trinitrate
Tree Number: T6.2.25.2
database_cross_reference: AOD:0000019732
database_cross_reference: AOD:0000028756
database_cross_reference: AOD:0000028758
database_cross_reference: AOD:0000028760
database_cross_reference: ATC:C01DA02
database_cross_reference: ATC:C05AE01
database_cross_reference: CHV:0000005601
database_cross_reference: CSP:2997-4864
database_cross_reference: DRUGBANK:DB00727
database_cross_reference: LCH:U005586
database_cross_reference: LCH_NW:sh85092085
database_cross_reference: LNC:LP18092-4
database_cross_reference: LNC:MTHU003375
database_cross_reference: MEDCIN:40541
database_cross_reference: MMSL:2324
database_cross_reference: MMSL:5183
database_cross_reference: MMSL:d00321
database_cross_reference: MSH:D005996
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:G59M7S0WS3
database_cross_reference: NCI:C29294
database_cross_reference: NCI_FDA:G59M7S0WS3
database_cross_reference: NCI_NCI-GLOSS:CDR0000626334
database_cross_reference: NDDF:000683
database_cross_reference: NDFRT:N0000006574
database_cross_reference: NDFRT:N0000145909
database_cross_reference: RCD:bl1..
database_cross_reference: RCD:blz..
database_cross_reference: RXNORM:4917
database_cross_reference: SNM:E-7694
database_cross_reference: SNMI:C-81560
database_cross_reference: SNOMEDCT_US:319379008
database_cross_reference: SNOMEDCT_US:387404004
database_cross_reference: SNOMEDCT_US:387623004
database_cross_reference: SNOMEDCT_US:71759000
database_cross_reference: USPMG:MTHU001069
database_cross_reference: VANDF:4017525

Nitrofurans
type: Class
subclass of: Nitro Compounds
subclass of: Furans
MCID: MC00008933
PMOID: PMO:00017210
Subclass_of: Furans
Subclass_of: Nitro Compounds
Synonym: Nitrofuran
Synonym: Nitrofuran (product)
Synonym: Nitrofurans [Chemical/Ingredient]
Synonym: nitrofuran
Synonym: nitrofurans
Tree Number: T6.2.25.4
Tree Number: T6.3.5.10.9
database_cross_reference: AOD:0000020733
database_cross_reference: CHV:0000008737
database_cross_reference: CSP:2079-0300
database_cross_reference: CSP:2188-5692
database_cross_reference: LCH:U003245
database_cross_reference: LCH_NW:sh85092061
database_cross_reference: MSH:D009581
database_cross_reference: NDFRT:N0000007658
database_cross_reference: SNOMEDCT_US:713382001

FANFT
type: Class
subclass of: Nitrofurans
subclass of: Thiazoles
MCID: MC00004962
PMOID: PMO:00017211
Subclass_of: Nitrofurans
Subclass_of: Thiazoles
Synonym: FANFT (formamidonitrofurylthiazole)
Synonym: FANFT [Chemical/Ingredient]
Synonym: Formamide, N-(4-(5-nitro-2-furanyl)-2-thiazolyl)-
Synonym: N-4-(5-Nitro-2-furyl)-2-thiazolylformamide
Synonym: formamidonitrofurylthiazole
Tree Number: T6.2.25.4.1
Tree Number: T6.2.32.13.8
database_cross_reference: CSP:2900-7151
database_cross_reference: MSH:D005200
database_cross_reference: NDFRT:N0000167135

Furagin
type: Class
subclass of: Nitrofurans
MCID: MC00005351
PMOID: PMO:00017212
Subclass_of: Nitrofurans
Synonym: 2,4-Imidazolidinedione, 1-((3-(5-nitro-2-furanyl)-2-propenylidene)amino)-
Synonym: Furagin [Chemical/Ingredient]
Tree Number: T6.2.25.4.2
database_cross_reference: MSH:D005661
database_cross_reference: NDFRT:N0000167133

Furazolidone
type: Class
subclass of: Nitrofurans
MCID: MC00005354
PMOID: PMO:00017213
Subclass_of: Nitrofurans
Synonym: 2-Oxazolidinone, 3-(((5-nitro-2-furanyl)methylene)amino)-
Synonym: 3-(5'-Nitrofurfuralamino)-2-oxazolidone
Synonym: 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone
Synonym: 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone
Synonym: 3-[(5-Nitrofurylidene)amino]-2-oxazolidone
Synonym: 3-{[(5-nitro-2-furanyl)methylene]amino}-2-oxazolidinone
Synonym: 5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine
Synonym: FURAZOLIDONE
Synonym: FZL
Synonym: Furazolidine
Tree Number: T6.2.25.4.3
database_cross_reference: AOD:0000020734
database_cross_reference: ATC:G01AX06
database_cross_reference: CHV:0000005297
database_cross_reference: DRUGBANK:DB00614
database_cross_reference: LCH_NW:sh97006431
database_cross_reference: LNC:LP140245-4
database_cross_reference: LNC:MTHU043008
database_cross_reference: MEDCIN:48406
database_cross_reference: MMSL:4768
database_cross_reference: MMSL:d00243
database_cross_reference: MSH:D005664
database_cross_reference: NCI:C65783
database_cross_reference: NCI_FDA:5J9CPU3RE0
database_cross_reference: NDDF:002855
database_cross_reference: NDFRT:N0000007173
database_cross_reference: NDFRT:N0000147172
database_cross_reference: RXNORM:4601
database_cross_reference: SNM:E-7162
database_cross_reference: SNMI:C-52030
database_cross_reference: SNOMEDCT_US:416556006
database_cross_reference: SNOMEDCT_US:91314000
database_cross_reference: VANDF:4018877

Furylfuramide
type: Class
subclass of: Nitrofurans
MCID: MC00005359
PMOID: PMO:00017214
Subclass_of: Nitrofurans
Synonym: 2-Furanacetamide, alpha-((5-nitro-2-furanyl)methylene)-
Synonym: Furylfuramide [Chemical/Ingredient]
Tree Number: T6.2.25.4.4
database_cross_reference: MSH:D005668
database_cross_reference: NDFRT:N0000167134

Nifuratel
type: Class
subclass of: Nitrofurans
MCID: MC00008896
PMOID: PMO:00017215
Subclass_of: Nitrofurans
Synonym: 2-Oxazolidinone, 5-((methylthio)methyl)-3-(((5-nitro-2-furanyl)methylene)amino)-
Synonym: Methylmercadone
Synonym: Metilmercadon
Synonym: Nifuratel (product)
Synonym: Nifuratel (substance)
Synonym: Nifuratel [Chemical/Ingredient]
Synonym: Thiodinon
Synonym: nifuratel
Synonym: nifuratel (medication)
Synonym: nifuratel (vaginal)
Tree Number: T6.2.25.4.5
database_cross_reference: ATC:G01AX05
database_cross_reference: LCH:U003232
database_cross_reference: LCH_NW:sh85091842
database_cross_reference: MEDCIN:198676
database_cross_reference: MEDCIN:198716
database_cross_reference: MSH:D009545
database_cross_reference: NDDF:005304
database_cross_reference: NDFRT:N0000167137
database_cross_reference: RXNORM:7419
database_cross_reference: SNOMEDCT_US:703418002
database_cross_reference: SNOMEDCT_US:703419005

Nifurtimox
type: Class
subclass of: Nitrofurans
subclass of: Thiazines
MCID: MC00008898
PMOID: PMO:00017216
Subclass_of: Nitrofurans
Subclass_of: Thiazines
Synonym: 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide
Synonym: 4-Thiomorpholinamine, 3-methyl-N-((5-nitro-2-furanyl)methylene)-, 1,1-dioxide
Synonym: NIFURTIMOX
Synonym: Nifurtimox (product)
Synonym: Nifurtimox (substance)
Synonym: Nifurtimox [Chemical/Ingredient]
Synonym: nifurtimox
Synonym: nifurtimox (medication)
Tree Number: T6.2.25.4.6
Tree Number: T6.2.32.12.3
Tree Number: T6.3.5.23.2
database_cross_reference: ATC:P01CC01
database_cross_reference: CHV:0000008715
database_cross_reference: DRUGBANK:DB11820
database_cross_reference: MEDCIN:40395
database_cross_reference: MSH:D009547
database_cross_reference: NCI:C71734
database_cross_reference: NCI_FDA:M84I3K7C2O
database_cross_reference: NDDF:007487
database_cross_reference: NDFRT:N0000167141
database_cross_reference: RXNORM:7421
database_cross_reference: SNMI:C-56910
database_cross_reference: SNOMEDCT_US:24869004
database_cross_reference: SNOMEDCT_US:714397006

Nitrofurantoin
type: Class
subclass of: Nitrofurans
MCID: MC00008934
PMOID: PMO:00017217
Subclass_of: Nitrofurans
Synonym: 1-((5-nitro-2-furanyl)methylene)amino-2,4-imidazolidenedione
Synonym: 1-((5-nitrofurfurylidene)amino)hydantoin
Synonym: 2,4-Imidazolidinedione, 1-(((5-nitro-2-furanyl)methylene)amino)-
Synonym: 5-Nitrofurantoin
Synonym: Auro-nitrofurantoin
Synonym: Furabid
Synonym: Macrodantin (100 Mg)
Synonym: Macrodantin (50 Mg)
Synonym: Macrodantin Cap 100mg
Synonym: Macrodantin Cap 25mg
Tree Number: T6.2.25.4.7
database_cross_reference: AOD:0000020735
database_cross_reference: ATC:J01XE01
database_cross_reference: CHV:0000008738
database_cross_reference: CSP:1548-6765
database_cross_reference: DRUGBANK:DB00698
database_cross_reference: LNC:LP16140-3
database_cross_reference: LNC:MTHU008460
database_cross_reference: MEDCIN:41525
database_cross_reference: MMSL:181427
database_cross_reference: MMSL:5179
database_cross_reference: MMSL:d00112
database_cross_reference: MSH:D009582
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:927AH8112L
database_cross_reference: NCI:C29293
database_cross_reference: NCI_FDA:927AH8112L
database_cross_reference: NDDF:002852
database_cross_reference: NDFRT:N0000006649
database_cross_reference: NDFRT:N0000147151
database_cross_reference: RCD:eg1..
database_cross_reference: RXNORM:7454
database_cross_reference: SNM:E-7166
database_cross_reference: SNMI:C-55620
database_cross_reference: SNOMEDCT_US:373543005
database_cross_reference: SNOMEDCT_US:85343003
database_cross_reference: USPMG:MTHU000230
database_cross_reference: VANDF:4018849

Nitrofurazone
type: Class
subclass of: Nitrofurans
MCID: MC00008935
PMOID: PMO:00017218
Subclass_of: Nitrofurans
Synonym: 5-Nitro-2-furaldehyde semicarbazone
Synonym: Furaderm
Synonym: Hydrazinecarboxamide, 2-((5-nitro-2-furanyl)methylene)-
Synonym: NITROFURAZONE
Synonym: Nitrofural
Synonym: Nitrofurazone (product)
Synonym: Nitrofurazone (substance)
Synonym: Nitrofurazone [Chemical/Ingredient]
Synonym: Nitrofurazone [dup] (substance)
Synonym: Nitrofurazone product
Tree Number: T6.2.25.4.8
database_cross_reference: ATC:B05CA03
database_cross_reference: ATC:D08AF01
database_cross_reference: ATC:D09AA03
database_cross_reference: ATC:P01CC02
database_cross_reference: ATC:S01AX04
database_cross_reference: ATC:S02AA02
database_cross_reference: CHV:0000008739
database_cross_reference: CSP:0316-4633
database_cross_reference: DRUGBANK:DB00336
database_cross_reference: LNC:LP149747-0
database_cross_reference: LNC:MTHU044410
database_cross_reference: LNC:MTHU048005
database_cross_reference: MEDCIN:198718
database_cross_reference: MEDCIN:40737
database_cross_reference: MMSL:2323
database_cross_reference: MMSL:5182
database_cross_reference: MSH:D009583
database_cross_reference: MTHSPL:X8XI70B5Z6
database_cross_reference: NCI:C73150
database_cross_reference: NCI_FDA:X8XI70B5Z6
database_cross_reference: NDDF:002857
database_cross_reference: NDFRT:N0000006652
database_cross_reference: NDFRT:N0000147174
database_cross_reference: RCD:XM0lT
database_cross_reference: RCD:mc7..
database_cross_reference: RXNORM:7455
database_cross_reference: SNM:E-7167
database_cross_reference: SNMI:C-90290
database_cross_reference: SNOMEDCT_US:273953000
database_cross_reference: SNOMEDCT_US:332799007
database_cross_reference: SNOMEDCT_US:411313003
database_cross_reference: SNOMEDCT_US:87097009
database_cross_reference: VANDF:4018879

Nitrovin
type: Class
subclass of: Nitrofurans
MCID: MC00008965
PMOID: PMO:00017219
Subclass_of: Nitrofurans
Synonym: Hydrazinecarboximidamide, 2-(3-(5-nitro-2-furanyl)-1-(2-(5-nitro-2-furanyl)ethenyl)-2-propenylidene)-
Synonym: Nitrovin [Chemical/Ingredient]
Tree Number: T6.2.25.4.9
database_cross_reference: MSH:D009610
database_cross_reference: NDFRT:N0000167132

5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole
type: Class
subclass of: Nitrofurans
MCID: MC00364552
PMOID: PMO:00017220
Subclass_of: Nitrofurans
Synonym: 1,2,4-Oxadiazol-5-amine, 3-(2-(5-nitro-2-furanyl)ethenyl)-, (E)-
Synonym: 5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole [Chemical/Ingredient]
Synonym: AMINONITROFURYLVINYL OXADIAZOLE 05 03 05 02 01 02
Tree Number: T6.2.25.4.10
database_cross_reference: MSH:D013184
database_cross_reference: NDFRT:N0000167136

Nitroimidazoles
type: Class
subclass of: Nitro Compounds
MCID: MC00008946
PMOID: PMO:00017221
Subclass_of: Nitro Compounds
Synonym: Nitroimidazole
Synonym: Nitroimidazole (product)
Synonym: Nitroimidazole (substance)
Synonym: Nitroimidazoles [Chemical/Ingredient]
Synonym: nitroimidazole
Synonym: nitroimidazoles
Tree Number: T6.2.25.5
database_cross_reference: AOD:0000020743
database_cross_reference: CHV:0000008744
database_cross_reference: LCH:U003249
database_cross_reference: LCH_NW:sh85092087
database_cross_reference: MSH:D009593
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007663
database_cross_reference: RCD:x01Ht
database_cross_reference: SNOMEDCT_US:350157004
database_cross_reference: SNOMEDCT_US:373235001

Dimetridazole
type: Class
subclass of: Nitroimidazoles
MCID: MC00003970
PMOID: PMO:00017222
Subclass_of: Nitroimidazoles
Synonym: 1H-Imidazole, 1,2-dimethyl-5-nitro-
Synonym: DIMETRIDAZOLE
Synonym: Dimetridazole [Chemical/Ingredient]
Tree Number: T6.2.25.5.1
database_cross_reference: MSH:D004131
database_cross_reference: MTHSPL:K59P7XNB8X
database_cross_reference: NCI:C76419
database_cross_reference: NCI_FDA:K59P7XNB8X
database_cross_reference: NDFRT:N0000167075
database_cross_reference: RXNORM:1600136

Ipronidazole
type: Class
subclass of: Nitroimidazoles
MCID: MC00007040
PMOID: PMO:00017223
Subclass_of: Nitroimidazoles
Synonym: 1H-Imidazole, 1-methyl-2-(1-methylethyl)-5-nitro-
Synonym: IPRONIDAZOLE
Synonym: Ipronidazole (product)
Synonym: Ipronidazole (substance)
Synonym: Ipronidazole [Chemical/Ingredient]
Tree Number: T6.2.25.5.2
database_cross_reference: MSH:D007491
database_cross_reference: NCI:C76423
database_cross_reference: NCI_FDA:045BU63E23
database_cross_reference: NDFRT:N0000167078
database_cross_reference: SNMI:C-56360
database_cross_reference: SNOMEDCT_US:373557007
database_cross_reference: SNOMEDCT_US:96103009

Metronidazole
type: Class
subclass of: Nitroimidazoles
MCID: MC00008265
PMOID: PMO:00017224
Subclass_of: Nitroimidazoles
Synonym: 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
Synonym: 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
Synonym: 1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
Synonym: 1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole
Synonym: 1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole
Synonym: 1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
Synonym: 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
Synonym: 1-(β-oxyethyl)-2-methyl-5-nitroimidazole
Synonym: 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-
Synonym: 2 Methyl 5 nitroimidazole 1 ethanol
Tree Number: T6.2.25.5.3
database_cross_reference: AOD:0000020744
database_cross_reference: ATC:A01AB17
database_cross_reference: ATC:D06BX01
database_cross_reference: ATC:G01AF01
database_cross_reference: ATC:J01XD01
database_cross_reference: ATC:P01AB01
database_cross_reference: CCPSS:0056481
database_cross_reference: CHV:0000008073
database_cross_reference: CSP:1549-4919
database_cross_reference: DRUGBANK:DB00916
database_cross_reference: LCH:U002950
database_cross_reference: LCH_NW:sh85084449
database_cross_reference: LNC:LP14997-8
database_cross_reference: LNC:MTHU002300
database_cross_reference: MEDCIN:132249
database_cross_reference: MEDCIN:40409
database_cross_reference: MMSL:4863
database_cross_reference: MMSL:5105
database_cross_reference: MMSL:d00108
database_cross_reference: MSH:D008795
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:140QMO216E
database_cross_reference: NCI:C651
database_cross_reference: NCI_FDA:140QMO216E
database_cross_reference: NCI_NCI-GLOSS:CDR0000045226
database_cross_reference: NDDF:002958
database_cross_reference: NDFRT:N0000005776
database_cross_reference: NDFRT:N0000146194
database_cross_reference: PDQ:CDR0000039503
database_cross_reference: RCD:ef1..
database_cross_reference: RCD:meg..
database_cross_reference: RXNORM:6922
database_cross_reference: SNM:E-737X
database_cross_reference: SNM:E-7402
database_cross_reference: SNMI:C-52040
database_cross_reference: SNOMEDCT_US:1222004
database_cross_reference: SNOMEDCT_US:332974000
database_cross_reference: SNOMEDCT_US:372602008
database_cross_reference: USPMG:MTHU000243
database_cross_reference: VANDF:4017836

Misonidazole
type: Class
subclass of: Nitroimidazoles
MCID: MC00008339
PMOID: PMO:00017225
Subclass_of: Nitroimidazoles
Synonym: 1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole
Synonym: 1H-Imidazole-1-ethanol, alpha-(methoxymethyl)-2-nitro-
Synonym: MISONIDAZOLE
Synonym: Misonidazole (substance)
Synonym: Misonidazole [Chemical/Ingredient]
Synonym: alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol
Synonym: misonidazole
Tree Number: T6.2.25.5.4
database_cross_reference: CSP:1549-5000
database_cross_reference: DRUGBANK:DB11716
database_cross_reference: MSH:D008920
database_cross_reference: NCI:C657
database_cross_reference: NCI_FDA:8FE7LTN8XE
database_cross_reference: NDFRT:N0000167077
database_cross_reference: PDQ:CDR0000039504
database_cross_reference: SNOMEDCT_US:423994009

Nimorazole
type: Class
subclass of: Nitroimidazoles
MCID: MC00008906
PMOID: PMO:00017226
Subclass_of: Nitroimidazoles
Synonym: 4-(2-(5-Nitroimidazol-1-yl)ethyl)morpholine
Synonym: Morpholine, 4-(2-(5-nitro-1H-imidazol-1-yl)ethyl)-
Synonym: NIMORAZOLE
Synonym: Nimorazole (product)
Synonym: Nimorazole (substance)
Synonym: Nimorazole [Chemical/Ingredient]
Synonym: Nitrimidazine
Synonym: nimorazole
Tree Number: T6.2.25.5.5
database_cross_reference: ATC:P01AB06
database_cross_reference: DRUGBANK:DB12172
database_cross_reference: MSH:D009554
database_cross_reference: NCI:C76425
database_cross_reference: NCI_FDA:469ULX0H4G
database_cross_reference: NDDF:004011
database_cross_reference: NDFRT:N0000167080
database_cross_reference: RCD:el1..
database_cross_reference: RXNORM:7427
database_cross_reference: SNOMEDCT_US:324945001
database_cross_reference: SNOMEDCT_US:418509004

Ornidazole
type: Class
subclass of: Nitroimidazoles
MCID: MC00009241
PMOID: PMO:00017227
Subclass_of: Nitroimidazoles
Synonym: 1H-Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro-
Synonym: Ornidazole (product)
Synonym: Ornidazole (substance)
Synonym: Ornidazole [Chemical/Ingredient]
Synonym: ornidazole
Tree Number: T6.2.25.5.6
database_cross_reference: ATC:G01AF06
database_cross_reference: ATC:J01XD03
database_cross_reference: ATC:P01AB03
database_cross_reference: DRUGBANK:DB13026
database_cross_reference: LNC:LP94840-3
database_cross_reference: LNC:MTHU032546
database_cross_reference: MSH:D009950
database_cross_reference: NDDF:005696
database_cross_reference: NDFRT:N0000167081
database_cross_reference: RXNORM:7701
database_cross_reference: SNOMEDCT_US:442845007
database_cross_reference: SNOMEDCT_US:442924004

Ronidazole
type: Class
subclass of: Nitroimidazoles
MCID: MC00011490
PMOID: PMO:00017228
Subclass_of: Nitroimidazoles
Synonym: 1H-Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate (ester)
Synonym: RONIDAZOLE
Synonym: Ronidazol
Synonym: Ronidazole [Chemical/Ingredient]
Tree Number: T6.2.25.5.7
database_cross_reference: MSH:D012385
database_cross_reference: MTHSPL:E01R4M1063
database_cross_reference: NDFRT:N0000167076
database_cross_reference: RXNORM:1535498

Tinidazole
type: Class
subclass of: Nitroimidazoles
MCID: MC00012881
PMOID: PMO:00017229
Subclass_of: Nitroimidazoles
Synonym: 1H-Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-
Synonym: TDZ
Synonym: TINIDAZOLE
Synonym: Timidazole
Synonym: Tindazole
Synonym: Tinidazole (product)
Synonym: Tinidazole (substance)
Synonym: Tinidazole [Chemical/Ingredient]
Synonym: tinidazole
Synonym: tinidazole (medication)
Tree Number: T6.2.25.5.8
database_cross_reference: ATC:J01XD02
database_cross_reference: ATC:P01AB02
database_cross_reference: CHV:0000012310
database_cross_reference: DRUGBANK:DB00911
database_cross_reference: LNC:LP90845-6
database_cross_reference: LNC:MTHU032217
database_cross_reference: MEDCIN:258950
database_cross_reference: MMSL:17775
database_cross_reference: MMSL:72539
database_cross_reference: MMSL:d04935
database_cross_reference: MSH:D014011
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:033KF7V46H
database_cross_reference: NCI:C890
database_cross_reference: NCI_FDA:033KF7V46H
database_cross_reference: NCI_NCI-GLOSS:CDR0000046153
database_cross_reference: NDDF:004057
database_cross_reference: NDFRT:N0000010549
database_cross_reference: NDFRT:N0000148851
database_cross_reference: PDQ:CDR0000043288
database_cross_reference: RCD:ef2..
database_cross_reference: RXNORM:10612
database_cross_reference: SNOMEDCT_US:324550004
database_cross_reference: SNOMEDCT_US:395907001
database_cross_reference: USPMG:MTHU000569
database_cross_reference: VANDF:4021467

Etanidazole
type: Class
subclass of: Nitroimidazoles
MCID: MC00026287
PMOID: PMO:00017230
Subclass_of: Nitroimidazoles
Synonym: 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-
Synonym: 2-Nitroimidazole-1-acetamide, N-(2-hydroxyethyl)-
Synonym: ETANIDAZOLE
Synonym: Etanidazole [Chemical/Ingredient]
Synonym: etanidazole
Tree Number: T6.2.25.5.9
database_cross_reference: CHV:0000013966
database_cross_reference: DRUGBANK:DB12736
database_cross_reference: MSH:D017341
database_cross_reference: NCI:C1092
database_cross_reference: NCI_DTP:NSC0301467
database_cross_reference: NCI_FDA:30DKA3Q1HL
database_cross_reference: NCI_NCI-GLOSS:CDR0000045213
database_cross_reference: NDFRT:N0000167079
database_cross_reference: PDQ:CDR0000039446

Nitroquinolines
type: Class
subclass of: Nitro Compounds
MCID: MC00008955
PMOID: PMO:00017231
Subclass_of: Nitro Compounds
Synonym: Nitroquinolines [Chemical/Ingredient]
Tree Number: T6.2.25.8
database_cross_reference: MSH:D009600
database_cross_reference: NDFRT:N0000007807

4-Nitroquinoline-1-oxide
type: Class
subclass of: Nitroquinolines
subclass of: Cyclic N-Oxides
MCID: MC00000082
PMOID: PMO:00017232
Subclass_of: Cyclic N-Oxides
Subclass_of: Nitroquinolines
Synonym: 4 Nitroquinoline 1 oxide
Synonym: 4 Nitroquinoline N oxide
Synonym: 4 nitroquinoline N oxide
Synonym: 4-NQO
Synonym: 4-Nitroquinoline N-oxide
Synonym: 4-Nitroquinoline-1-Oxide
Synonym: 4-Nitroquinoline-1-oxide [Chemical/Ingredient]
Synonym: 4-Nitroquinoline-N-oxide
Synonym: 4-nitroquinoline 1-oxide
Synonym: NITROQUINOLINE A OXIDE 04 01
Tree Number: T6.2.25.8.1
Tree Number: T6.3.6.1.3
database_cross_reference: CSP:2530-4230
database_cross_reference: MSH:D015112
database_cross_reference: NCI:C194
database_cross_reference: NCI_NCI-GLOSS:CDR0000367450
database_cross_reference: NCI_NCI-GLOSS:CDR0000367451
database_cross_reference: NDFRT:N0000167039

Nitroso Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00008959
PMOID: PMO:00017233
Subclass_of: Organic Chemicals
Synonym: Compounds, Nitroso
Synonym: NITROSO CPDS
Synonym: Nitroso Compounds [Chemical/Ingredient]
Synonym: Nitroso compounds
Synonym: Nitroso-compounds
Synonym: nitroso compound
Synonym: nitroso compounds
Tree Number: T6.2.26
database_cross_reference: AOD:0000019392
database_cross_reference: CSP:2081-6522
database_cross_reference: LCH:U003251
database_cross_reference: LCH_NW:sh85092091
database_cross_reference: MSH:D009603
database_cross_reference: NDFRT:N0000008203

Nitrosamines
type: Class
subclass of: Nitroso Compounds
MCID: MC00008957
PMOID: PMO:00017234
Subclass_of: Nitroso Compounds
Synonym: Nitrosamine
Synonym: Nitrosamine (substance)
Synonym: Nitrosamine compound
Synonym: Nitrosamine, NOS
Synonym: Nitrosamines [Chemical/Ingredient]
Synonym: nitrosamine
Synonym: nitrosamines
Tree Number: T6.2.26.1
database_cross_reference: AOD:0000019393
database_cross_reference: CHV:0000008746
database_cross_reference: CSP:0119-0625
database_cross_reference: MSH:D009602
database_cross_reference: NCI:C698
database_cross_reference: NCI_DTP:NSC0223080
database_cross_reference: NCI_NCI-GLOSS:CDR0000658447
database_cross_reference: NDFRT:N0000166747
database_cross_reference: SNM:E-6961
database_cross_reference: SNMI:C-29080
database_cross_reference: SNOMEDCT_US:25931000

Butylhydroxybutylnitrosamine
type: Class
subclass of: Nitrosamines
MCID: MC00002058
PMOID: PMO:00017235
Subclass_of: Nitrosamines
Synonym: 1-Butanol, 4-(butylnitrosoamino)-
Synonym: Butylbutanolnitrosamine
Synonym: Butylhydroxybutylnitrosamine [Chemical/Ingredient]
Synonym: N Nitrosobutyl 4 hydroxybutylamine
Synonym: N-Butyl-N-(4-hydroxybutyl)nitrosamine
Synonym: N-Nitroso-N-butyl-(4-hydroxybutyl)amine
Synonym: N-Nitrosobutyl-4-hydroxybutylamine
Synonym: N-butyl-N-(4-hydroxybutyl) nitrosamine
Synonym: N-butyl-N-(4-hydroxybutyl)nitrosamine
Tree Number: T6.2.26.1.1
database_cross_reference: MSH:D002085
database_cross_reference: NCI:C29826
database_cross_reference: NCI_NCI-GLOSS:CDR0000372935
database_cross_reference: NDFRT:N0000166750

Diethylnitrosamine
type: Class
subclass of: Nitrosamines
MCID: MC00003892
PMOID: PMO:00017236
Subclass_of: Nitrosamines
Synonym: DENA
Synonym: Diethylnitrosamine [Chemical/Ingredient]
Synonym: Ethanamine, N-ethyl-N-nitroso-
Synonym: N Nitrosodiethylamine
Synonym: N,N-diethylnitrosamine
Synonym: N-NITROSODIETHYLAMINE
Synonym: N-Nitrosodiethylamine
Synonym: N-ethyl-N-nitroso-ethanamine
Synonym: NDEA
Synonym: Nitrosodiethylamine
Tree Number: T6.2.26.1.2
database_cross_reference: CHV:0000003927
database_cross_reference: CSP:0119-0650
database_cross_reference: MSH:D004052
database_cross_reference: NCI:C29827
database_cross_reference: NCI_FDA:3IQ78TTX1A
database_cross_reference: NDFRT:N0000166748

Dimethylnitrosamine
type: Class
subclass of: Nitrosamines
MCID: MC00003968
PMOID: PMO:00017237
Subclass_of: Nitrosamines
Synonym: DMN
Synonym: DMNA
Synonym: Dimethylnitrosamine [Chemical/Ingredient]
Synonym: Methanamine, N-methyl-N-nitroso-
Synonym: N Nitrosodimethylamine
Synonym: N nitrosodimethylamine
Synonym: N-Methyl-N-nitrosomethanamine
Synonym: N-NITROSODIMETHYLAMINE
Synonym: N-Nitrosodimethylamine
Synonym: N-nitrosodimethylamine
Tree Number: T6.2.26.1.3
database_cross_reference: AOD:0000019394
database_cross_reference: AOD:0000028702
database_cross_reference: AOD:0000028703
database_cross_reference: CHV:0000003967
database_cross_reference: CSP:0119-0625
database_cross_reference: LCH_NW:sh88001004
database_cross_reference: LNC:LP34821-6
database_cross_reference: LNC:MTHU017307
database_cross_reference: MSH:D004128
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44417
database_cross_reference: NCI_FDA:M43H21IO8R
database_cross_reference: NDFRT:N0000166749

N-Nitrosopyrrolidine
type: Class
subclass of: Nitrosamines
subclass of: Pyrrolidines
MCID: MC00008614
PMOID: PMO:00017238
Subclass_of: Nitrosamines
Subclass_of: Pyrrolidines
Synonym: 1-Nitrosopyrrolidine
Synonym: N Nitrosopyrrolidine
Synonym: N-NITROSOPYRROLIDINE
Synonym: N-Nitrosopyrrolidine [Chemical/Ingredient]
Synonym: NITROSOPYRROLIDINE N
Synonym: NO-PYR
Synonym: NPYR
Synonym: Pyrrolidine, 1-nitroso-
Synonym: Tetrahydro-N-nitroso-pyrrole
Tree Number: T6.2.26.1.4
Tree Number: T6.3.5.22.5
database_cross_reference: MSH:D009242
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44424
database_cross_reference: NCI_FDA:SZ4J5WK201
database_cross_reference: NDFRT:N0000167157

Nitrosourea Compounds
type: Class
subclass of: Nitroso Compounds
subclass of: Urea
MCID: MC00008962
PMOID: PMO:00017239
Subclass_of: Nitroso Compounds
Subclass_of: Urea
Synonym: Compounds, Nitrosourea
Synonym: NITROSOUREA CPDS
Synonym: Nitrosourea Compound
Synonym: Nitrosourea Compounds [Chemical/Ingredient]
Synonym: Nitrosoureas
Synonym: Nitrosureas
Synonym: Nitrosureas (product)
Synonym: Nitrosureas (substance)
Synonym: nitrosourea
Synonym: nitrosoureas
Tree Number: T6.2.26.4
Tree Number: T6.2.34.7
database_cross_reference: CHV:0000008747
database_cross_reference: CSP:2082-9272
database_cross_reference: LCH:U005852
database_cross_reference: LCH_NW:sh85092094
database_cross_reference: MSH:D009607
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C699
database_cross_reference: NCI_NCI-GLOSS:CDR0000046062
database_cross_reference: NDFRT:N0000007812
database_cross_reference: PDQ:CDR0000042134
database_cross_reference: RCD:x01AX
database_cross_reference: SNOMEDCT_US:349843000
database_cross_reference: SNOMEDCT_US:372610009

Carmustine
type: Class
subclass of: Nitrosourea Compounds
MCID: MC00002329
PMOID: PMO:00017240
Subclass_of: Nitrosourea Compounds
Synonym: 1,3-Bis(2-Chloroethyl)-1-Nitrosourea
Synonym: 1,3-Bis(2-chloroethyl)-1-nitrosourea
Synonym: 1,3-Bis(beta-chloroethyl)-1-nitrosourea
Synonym: BCNU
Synonym: BCNU (bis chloroethylnitrosourea)
Synonym: BCNU - Carmustine
Synonym: Bis(chloroethyl) Nitrosourea
Synonym: Bis-Chloronitrosourea
Synonym: Bischloroethyl nitrosourea
Synonym: CAMUSTINE
Tree Number: T6.2.26.4.1
Tree Number: T6.2.34.7.1
database_cross_reference: ATC:L01AD01
database_cross_reference: CHV:0000002467
database_cross_reference: CSP:1371-8039
database_cross_reference: DRUGBANK:DB00262
database_cross_reference: MEDCIN:40498
database_cross_reference: MMSL:4360
database_cross_reference: MMSL:d01342
database_cross_reference: MSH:D002330
database_cross_reference: MTHSPL:U68WG3173Y
database_cross_reference: NCI:C349
database_cross_reference: NCI_DTP:NSC0409962
database_cross_reference: NCI_FDA:U68WG3173Y
database_cross_reference: NCI_NCI-GLOSS:CDR0000045976
database_cross_reference: NDDF:002640
database_cross_reference: NDFRT:N0000006684
database_cross_reference: NDFRT:N0000146473
database_cross_reference: NDFRT:N0000148463
database_cross_reference: PDQ:CDR0000043027
database_cross_reference: RCD:h12..
database_cross_reference: RXNORM:2105
database_cross_reference: SNM:E-8371
database_cross_reference: SNMI:C-78040
database_cross_reference: SNOMEDCT_US:387281007
database_cross_reference: SNOMEDCT_US:51326002
database_cross_reference: VANDF:4018136
database_cross_reference: VANDF:4020993

Ethylnitrosourea
type: Class
subclass of: Nitrosourea Compounds
MCID: MC00004817
PMOID: PMO:00017241
Subclass_of: Nitrosourea Compounds
Synonym: 1-Ethyl-1-nitrosourea
Synonym: ENU
Synonym: Ethylnitrosourea [Chemical/Ingredient]
Synonym: N Ethyl N nitrosourea
Synonym: N-ETHYL-N-NITROSOUREA
Synonym: N-Ethyl-N-nitrosourea
Synonym: N-Nitroso-N-Ethylurea
Synonym: Nitrosoethylurea
Synonym: Urea, N-ethyl-N-nitroso-
Tree Number: T6.2.26.4.2
Tree Number: T6.2.34.7.2
database_cross_reference: MSH:D005038
database_cross_reference: NCI:C26563
database_cross_reference: NCI_FDA:P8M1T4190R
database_cross_reference: NDFRT:N0000166752

Lomustine
type: Class
subclass of: Nitrosourea Compounds
MCID: MC00007665
PMOID: PMO:00017242
Subclass_of: Nitrosourea Compounds
Synonym: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
Synonym: 1-(2-Chloroethyl)-3-cyclohexylnitrosourea
Synonym: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Synonym: 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-
Synonym: CINU
Synonym: Chloroethylcyclo- hexylnitrosourea
Synonym: Chloroethylcyclo-hexylnitrosourea
Synonym: Chloroethylcyclohexylnitrosourea
Synonym: Cyclohexyl chloroethyl nitrosourea
Synonym: LOMUSTINE
Tree Number: T6.2.26.4.3
Tree Number: T6.2.34.7.3
database_cross_reference: ATC:L01AD02
database_cross_reference: CHV:0000007530
database_cross_reference: CSP:1371-8111
database_cross_reference: DRUGBANK:DB01206
database_cross_reference: MEDCIN:40511
database_cross_reference: MMSL:4991
database_cross_reference: MMSL:52513
database_cross_reference: MMSL:d01341
database_cross_reference: MSH:D008130
database_cross_reference: MTHSPL:7BRF0Z81KG
database_cross_reference: NCI:C617
database_cross_reference: NCI_DTP:NSC0079037
database_cross_reference: NCI_FDA:7BRF0Z81KG
database_cross_reference: NCI_NCI-GLOSS:CDR0000046017
database_cross_reference: NDDF:002639
database_cross_reference: NDFRT:N0000007072
database_cross_reference: NDFRT:N0000146475
database_cross_reference: PDQ:CDR0000043065
database_cross_reference: RCD:h18..
database_cross_reference: RXNORM:6466
database_cross_reference: SNM:E-8372
database_cross_reference: SNMI:C-78120
database_cross_reference: SNOMEDCT_US:387227009
database_cross_reference: SNOMEDCT_US:40999006
database_cross_reference: USPMG:MTHU000472
database_cross_reference: VANDF:4018138

Methylnitrosourea
type: Class
subclass of: Nitrosourea Compounds
MCID: MC00008240
PMOID: PMO:00017244
Subclass_of: Nitrosourea Compounds
Synonym: 1-Methyl-1-nitrosourea
Synonym: MNU
Synonym: Methylnitrosourea [Chemical/Ingredient]
Synonym: N Methyl N nitrosourea
Synonym: N-Methyl-N-nitrosourea
Synonym: N-Nitroso-N-Methylurea
Synonym: N-methyl-N-nitrosourea
Synonym: N-nitroso-N-methylcarbamide
Synonym: NMH
Synonym: NMU
Tree Number: T6.2.26.4.4
Tree Number: T6.2.34.7.4
database_cross_reference: CHV:0000008062
database_cross_reference: CSP:2082-9500
database_cross_reference: MSH:D008770
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C645
database_cross_reference: NCI_DTP:NSC0023909
database_cross_reference: NDFRT:N0000166755

Streptozocin
type: Class
subclass of: Nitrosourea Compounds
subclass of: PMO:00020951
MCID: MC00012273
PMOID: PMO:00017245
Subclass_of: Aminoglycosides
Subclass_of: Nitrosourea Compounds
Synonym: 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose
Synonym: 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose
Synonym: 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
Synonym: 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
Synonym: 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose
Synonym: D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-
Synonym: Estreptozocina
Synonym: N-D-Glucosyl-(2)-n'-nitrosomethylharnstoff
Synonym: N-D-Glucosyl-(2)-n'-nitrosomethylurea
Synonym: STREPTOZOCIN
Tree Number: T6.2.26.4.5
Tree Number: T6.2.34.7.5
Tree Number: T6.8.6.1.11
database_cross_reference: ATC:L01AD04
database_cross_reference: CHV:0000011769
database_cross_reference: CSP:0209-0268
database_cross_reference: DRUGBANK:DB00428
database_cross_reference: LCH:U004498
database_cross_reference: LCH_NW:sh85128700
database_cross_reference: MEDCIN:40532
database_cross_reference: MEDCIN:48467
database_cross_reference: MMSL:5515
database_cross_reference: MMSL:d00375
database_cross_reference: MSH:D013311
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5W494URQ81
database_cross_reference: NCI:C845
database_cross_reference: NCI_DCP:00238
database_cross_reference: NCI_DTP:NSC0085998
database_cross_reference: NCI_FDA:5W494URQ81
database_cross_reference: NCI_NCI-GLOSS:CDR0000045561
database_cross_reference: NDDF:002663
database_cross_reference: NDFRT:N0000005914
database_cross_reference: NDFRT:N0000146432
database_cross_reference: PDQ:CDR0000042831
database_cross_reference: RXNORM:10114
database_cross_reference: SNM:E-8374
database_cross_reference: SNMI:C-781D0
database_cross_reference: SNOMEDCT_US:16915004
database_cross_reference: SNOMEDCT_US:404876000
database_cross_reference: VANDF:4018094

Nimustine
type: Class
subclass of: Nitrosourea Compounds
MCID: MC00008907
PMOID: PMO:00017246
Subclass_of: Nitrosourea Compounds
Synonym: 3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea
Synonym: ACNU
Synonym: N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea
Synonym: N'-[4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea
Synonym: NIMUSTINE
Synonym: Nimustine [Chemical/Ingredient]
Synonym: Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-
Synonym: acnu
Synonym: nimustine
Tree Number: T6.2.26.4.6
Tree Number: T6.2.34.7.6
database_cross_reference: ATC:L01AD06
database_cross_reference: CHV:0000008723
database_cross_reference: DRUGBANK:DB13069
database_cross_reference: MSH:D015376
database_cross_reference: NCI:C693
database_cross_reference: NCI_DTP:NSC0245382
database_cross_reference: NCI_FDA:0S726V972K
database_cross_reference: NCI_NCI-GLOSS:CDR0000455140
database_cross_reference: NDDF:006595
database_cross_reference: NDFRT:N0000166753
database_cross_reference: PDQ:CDR0000038853

S-Nitrosothiols
type: Class
subclass of: Reactive Nitrogen Species
subclass of: Sulfhydryl Compounds
MCID: MC00055632
PMOID: PMO:00017247
Subclass_of: Reactive Nitrogen Species
Subclass_of: Sulfhydryl Compounds
Synonym: NITROSOTHIOLS S
Synonym: S-Nitrosothiol
Synonym: S-Nitrosothiols [Chemical/Ingredient]
Synonym: s-nitrosothiols
Tree Number: T6.2.26.5.1
Tree Number: T6.2.32.6.15
database_cross_reference: CHV:0000016480
database_cross_reference: MSH:D026403
database_cross_reference: NDFRT:N0000166744

Onium Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00009177
PMOID: PMO:00017250
Subclass_of: Organic Chemicals
Synonym: Compounds, Onium
Synonym: ONIUM CPDS
Synonym: Onium Compounds [Chemical/Ingredient]
Tree Number: T6.2.27
database_cross_reference: MSH:D009861
database_cross_reference: NDFRT:N0000008138

Sulfonium Compounds
type: Class
subclass of: Sulfur Compounds
subclass of: Onium Compounds
MCID: MC00012406
PMOID: PMO:00017251
Subclass_of: Onium Compounds
Subclass_of: Sulfur Compounds
Synonym: Compounds, Sulfonium
Synonym: SULFONIUM CPDS
Synonym: Sulfonium Compounds [Chemical/Ingredient]
Synonym: sulfonium compound
Tree Number: T6.2.27.2
Tree Number: T6.2.32.9
database_cross_reference: CSP:2842-2775
database_cross_reference: MSH:D013452
database_cross_reference: NDFRT:N0000166439

Organometallic Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00009232
PMOID: PMO:00017252
Subclass_of: Organic Chemicals
Synonym: 224 ORGANIC METALLIC COMPOUNDS
Synonym: Compounds, Metallo-Organic
Synonym: Compounds, Metalloorganic
Synonym: Compounds, Organometallic
Synonym: METALLO ORG CPDS
Synonym: Metallo Organic Compounds
Synonym: Metallo-Organic Compounds
Synonym: Metalloorganic Compounds
Synonym: ORGANIC METALLIC COMPOUNDS
Synonym: ORGANOMETALLIC CPDS
Tree Number: T6.2.28
database_cross_reference: AOD:0000021049
database_cross_reference: CSP:1851-7464
database_cross_reference: LCH:U003378
database_cross_reference: LCH_NW:sh85095561
database_cross_reference: MSH:D009942
database_cross_reference: NCI:C719
database_cross_reference: NDFRT:N0000007683
database_cross_reference: SNM:E-6020
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:C-22400
database_cross_reference: SNOMEDCT_US:11621003

Metal-Organic Frameworks
type: Class
subclass of: Organometallic Compounds
subclass of: Polymers
PMOID: PMO:00017253
Subclass_of: Organometallic Compounds
Subclass_of: Polymers
Tree Number: T6.2.28.1
Tree Number: T6.5.2.2

Metallocenes
type: Class
subclass of: Organometallic Compounds
PMOID: PMO:00017254
Subclass_of: Organometallic Compounds
Tree Number: T6.2.28.2

Antimony Potassium Tartrate
type: Class
subclass of: Organometallic Compounds
MCID: MC00001086
PMOID: PMO:00017255
Subclass_of: Organometallic Compounds
Synonym: ANTIMONY POTASSIUM TARTRATE
Synonym: Antimonate(2-), bis(mu-(2,3-dihydroxybutanedioato(4-)-O1,O2:O3,O4))di-, dipotassium, trihydrate, stereoisomer
Synonym: Antimony Potassium Tartrate [Chemical/Ingredient]
Synonym: Antimony potassium tartrate
Synonym: Antimony potassium tartrate (substance)
Synonym: Antimony, Tartrated
Synonym: Antimonyltartrate, Potassium
Synonym: Emetic, Tartar
Synonym: Potassium Antimonyltartrate
Synonym: Potassium Tartrate, Antimony
Tree Number: T6.2.28.3
database_cross_reference: CHV:0000001310
database_cross_reference: LCH_NW:sh85132705
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000966
database_cross_reference: MTHSPL:DL6OZ476V3
database_cross_reference: NCI:C76863
database_cross_reference: NCI_FDA:DL6OZ476V3
database_cross_reference: NDDF:002966
database_cross_reference: NDFRT:N0000006951
database_cross_reference: NDFRT:N0000147345
database_cross_reference: RXNORM:981
database_cross_reference: SNM:E-7432
database_cross_reference: SNMI:C-56712
database_cross_reference: SNOMEDCT_US:54340002
database_cross_reference: VANDF:4019084

Arsanilic Acid
type: Class
subclass of: Arsenicals
MCID: MC00001241
PMOID: PMO:00017256
Subclass_of: Arsenicals
Synonym: (4-aminophenyl)arsonic Acid
Synonym: (p-aminophenyl)arsonic acid
Synonym: 4 Aminobenzenearsonic Acid
Synonym: 4-Aminobenzenearsonic Acid
Synonym: 4-Aminophenylarsonic acid
Synonym: 4-Aminophenylarsonsäure
Synonym: 4-Arsanilic Acid
Synonym: 4-aminobenzenearsonic acid
Synonym: 4-arsanilic acid
Synonym: ARSANILIC ACID
Tree Number: T6.2.28.5.1
database_cross_reference: DRUGBANK:DB03006
database_cross_reference: MSH:D001147
database_cross_reference: NCI:C29883
database_cross_reference: NCI_FDA:UDX9AKS7GM
database_cross_reference: NDFRT:N0000166780
database_cross_reference: SNMI:C-11560
database_cross_reference: SNOMEDCT_US:111067003

Arsenamide
type: Class
subclass of: Arsenicals
MCID: MC00001242
PMOID: PMO:00017257
Subclass_of: Arsenicals
Synonym: 2,2'-(((4-(aminocarbonyl)phenyl)arsinidene)bis(thio))bisacetic Acid
Synonym: 4-carbamylphenyl bis(carboxymethylthio)arsenite
Synonym: Acetic acid, 2,2'-(((4-(aminocarbonyl)phenyl)arsinidene)bis(thio))bis-
Synonym: Arsenamide (substance)
Synonym: Arsenamide [Chemical/Ingredient]
Synonym: THIACETARSAMIDE
Synonym: Thiacetarsamide
Synonym: Thioarsenite
Tree Number: T6.2.28.5.2
database_cross_reference: MSH:D001148
database_cross_reference: NCI:C66595
database_cross_reference: NCI_FDA:VMF4ELY9TZ
database_cross_reference: NDFRT:N0000166778
database_cross_reference: SNOMEDCT_US:421629003

Arsphenamine
type: Class
subclass of: Arsenicals
MCID: MC00001247
PMOID: PMO:00017258
Subclass_of: Arsenicals
Synonym: Arsenobenzol
Synonym: Arsphenamine [Chemical/Ingredient]
Synonym: Phenol, 4,4'-(1,2-diarsenediyl)bis(2-amino)-, dihydrochloride
Synonym: arsphenamine
Tree Number: T6.2.28.5.5
database_cross_reference: CHV:0000001445
database_cross_reference: LCH:U000362
database_cross_reference: LCH_NW:sh85007460
database_cross_reference: MSH:D001153
database_cross_reference: NDFRT:N0000166779

Cacodylic Acid
type: Class
subclass of: Arsenicals
MCID: MC00002083
PMOID: PMO:00017259
Subclass_of: Arsenicals
Synonym: Acid, Cacodylic
Synonym: Acid, Dimethylarsinic
Synonym: Arsinic acid, dimethyl-
Synonym: CACODYLIC ACID
Synonym: Cacodylic Acid [Chemical/Ingredient]
Synonym: Cacodylic acid
Synonym: Dimethylarsenic acid
Synonym: Dimethylarsinic Acid
Synonym: Dimethylarsinic acid
Synonym: Hydroxydimethylarsine oxide
Tree Number: T6.2.28.5.6
database_cross_reference: CHV:0000002275
database_cross_reference: DRUGBANK:DB02994
database_cross_reference: LCH_NW:sh87003500
database_cross_reference: MSH:D002101
database_cross_reference: NCI:C80595
database_cross_reference: NCI_FDA:AJ2HL7EU8K
database_cross_reference: NDFRT:N0000006472

Melarsoprol
type: Class
subclass of: Arsenicals
MCID: MC00008001
PMOID: PMO:00017260
Subclass_of: Arsenicals
Synonym: 1,3,2-Dithiarsolane-4-methanol, 2-(4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)-
Synonym: Melarsoprol (product)
Synonym: Melarsoprol (substance)
Synonym: Melarsoprol [Chemical/Ingredient]
Synonym: melarsoprol
Tree Number: T6.2.28.5.7
database_cross_reference: ATC:P01CD01
database_cross_reference: CHV:0000007898
database_cross_reference: DRUGBANK:DB12864
database_cross_reference: MSH:D008549
database_cross_reference: NDDF:002964
database_cross_reference: NDFRT:N0000166777
database_cross_reference: SNM:E-7397
database_cross_reference: SNMI:C-56914
database_cross_reference: SNOMEDCT_US:17990002
database_cross_reference: SNOMEDCT_US:714136007

Roxarsone
type: Class
subclass of: Arsenicals
MCID: MC00011502
PMOID: PMO:00017261
Subclass_of: Arsenicals
Synonym: 3 Nitro 4 Hydroxyphenylarsonic Acid
Synonym: 3-Nitro-4-Hydroxyphenylarsonic Acid
Synonym: Acid, 3-Nitro-4-Hydroxyphenylarsonic
Synonym: Arsonic acid, (4-hydroxy-3-nitrophenyl)-
Synonym: ROXARSONE
Synonym: Roxarsone (product)
Synonym: Roxarsone (substance)
Synonym: Roxarsone [Chemical/Ingredient]
Tree Number: T6.2.28.5.9
database_cross_reference: MSH:D012406
database_cross_reference: NCI:C76429
database_cross_reference: NCI_FDA:H5GU9YQL7L
database_cross_reference: NDFRT:N0000166774
database_cross_reference: RXNORM:1314413
database_cross_reference: SNMI:C-52060
database_cross_reference: SNOMEDCT_US:96006004
database_cross_reference: SNOMEDCT_VET:6191000009108

Organomercury Compounds
type: Class
subclass of: Organometallic Compounds
MCID: MC00009231
PMOID: PMO:00017262
Subclass_of: Organometallic Compounds
Synonym: Compounds, Organomercury
Synonym: ORGANOMERCURY CPDS
Synonym: Organomercury Compounds [Chemical/Ingredient]
Synonym: Organomercury compounds
Synonym: organomercury compounds
Tree Number: T6.2.28.7
database_cross_reference: AOD:0000021051
database_cross_reference: LCH:U003377
database_cross_reference: LCH_NW:sh85095560
database_cross_reference: MSH:D009941
database_cross_reference: NDFRT:N0000007682

Alkylmercury Compounds
type: Class
subclass of: Organomercury Compounds
MCID: MC00000570
PMOID: PMO:00017263
Subclass_of: Organomercury Compounds
Synonym: ALKYL MERCURY CPDS
Synonym: ALKYLMERCURY CPDS
Synonym: Alkyl Mercury Compounds
Synonym: Alkylmercurials
Synonym: Alkylmercury Compounds [Chemical/Ingredient]
Synonym: Compounds, Alkyl Mercury
Synonym: Compounds, Alkylmercury
Synonym: Mercury Compounds, Alkyl
Tree Number: T6.2.28.7.1
database_cross_reference: MSH:D000479
database_cross_reference: NDFRT:N0000008135

Merbromin
type: Class
subclass of: Organomercury Compounds
MCID: MC00008084
PMOID: PMO:00017271
Subclass_of: Organomercury Compounds
Synonym: 2,7-Dibromo-4-hydroxymercurifluoresceine disodium salt
Synonym: Asceptichrome
Synonym: Aseptichrome
Synonym: Chromargyre
Synonym: Fluorochrome
Synonym: MERBROMIN
Synonym: Merbromin (product)
Synonym: Merbromin (substance)
Synonym: Merbromin [Chemical/Ingredient]
Synonym: Merbromine
Tree Number: T6.2.28.7.2
database_cross_reference: CHV:0000007974
database_cross_reference: DRUGBANK:DB13392
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D008622
database_cross_reference: NCI:C82319
database_cross_reference: NCI_FDA:M0T18YH28D
database_cross_reference: NDDF:003129
database_cross_reference: NDFRT:N0000006414
database_cross_reference: NDFRT:N0000148151
database_cross_reference: RXNORM:6762
database_cross_reference: SNM:E-7125
database_cross_reference: SNMI:C-902C0
database_cross_reference: SNOMEDCT_US:19126005
database_cross_reference: SNOMEDCT_US:715475003
database_cross_reference: VANDF:4020260

Phenylmercury Compounds
type: Class
subclass of: Organomercury Compounds
MCID: MC00010053
PMOID: PMO:00017272
Subclass_of: Organomercury Compounds
Synonym: Compounds, Phenyl Mercury
Synonym: Compounds, Phenylmercury
Synonym: Mercury Compounds, Phenyl
Synonym: PHENYL MERCURY CPDS
Synonym: PHENYLMERCURY CPDS
Synonym: Phenyl Mercury Compounds
Synonym: Phenylmercurials
Synonym: Phenylmercury Compounds [Chemical/Ingredient]
Tree Number: T6.2.28.7.3
database_cross_reference: MSH:D010663
database_cross_reference: NDFRT:N0000007560

Organoplatinum Compounds
type: Class
subclass of: Organometallic Compounds
MCID: MC00009234
PMOID: PMO:00017275
Subclass_of: Organometallic Compounds
Synonym: Compounds, Organoplatinum
Synonym: ORGANOPLATINUM CPDS
Synonym: Organoplatinum Compounds [Chemical/Ingredient]
Synonym: Organoplatinum compounds
Tree Number: T6.2.28.8
database_cross_reference: LCH:U003380
database_cross_reference: LCH_NW:sh85095570
database_cross_reference: MSH:D009944
database_cross_reference: NDFRT:N0000007685

Carboplatin
type: Class
subclass of: Organoplatinum Compounds
MCID: MC00041025
PMOID: PMO:00017276
Subclass_of: Organoplatinum Compounds
Synonym: (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum
Synonym: 1,1-cyclobutanedicarboxylic acid platinum complex
Synonym: CARBOPLATIN
Synonym: CARBOplatin
Synonym: CBDCA
Synonym: CBDCA - Carboplatin
Synonym: Carboplatin (product)
Synonym: Carboplatin (substance)
Synonym: Carboplatin Injection BP
Synonym: Carboplatin Injection Liq 10mg/ml
Tree Number: T6.2.28.8.1
database_cross_reference: ATC:L01XA02
database_cross_reference: CHV:0000015104
database_cross_reference: CSP:4007-0021
database_cross_reference: DRUGBANK:DB00958
database_cross_reference: MEDCIN:48464
database_cross_reference: MMSL:37674
database_cross_reference: MMSL:4357
database_cross_reference: MMSL:d00185
database_cross_reference: MSH:D016190
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:BG3F62OND5
database_cross_reference: NCI:C1282
database_cross_reference: NCI_DTP:NSC0241240
database_cross_reference: NCI_FDA:BG3F62OND5
database_cross_reference: NCI_NCI-GLOSS:CDR0000045182
database_cross_reference: NDDF:002643
database_cross_reference: NDFRT:N0000007164
database_cross_reference: NDFRT:N0000147598
database_cross_reference: PDQ:CDR0000039176
database_cross_reference: RCD:h52..
database_cross_reference: RXNORM:40048
database_cross_reference: SNOMEDCT_US:108759002
database_cross_reference: SNOMEDCT_US:386905002
database_cross_reference: VANDF:4019478

Organotin Compounds
type: Class
subclass of: Organometallic Compounds
MCID: MC00009237
PMOID: PMO:00017277
Subclass_of: Organometallic Compounds
Synonym: Compounds, Organotin
Synonym: ORGANOTIN CPDS
Synonym: Organic tin compound
Synonym: Organic tin compound (substance)
Synonym: Organic tin compound, NOS
Synonym: Organotin
Synonym: Organotin Compounds [Chemical/Ingredient]
Synonym: Organotin compound
Synonym: Organotin compounds
Synonym: organotin
Tree Number: T6.2.28.9
database_cross_reference: CHV:0000009029
database_cross_reference: LCH:U003382
database_cross_reference: LCH_NW:sh85095581
database_cross_reference: MSH:D009947
database_cross_reference: NDFRT:N0000166783
database_cross_reference: SNMI:C-13930
database_cross_reference: SNOMEDCT_US:41748003

Trialkyltin Compounds
type: Class
subclass of: Organotin Compounds
MCID: MC00013041
PMOID: PMO:00017278
Subclass_of: Organotin Compounds
Synonym: Compounds, Trialkyltin
Synonym: TRIALKYLTIN CPDS
Synonym: Trialkyltin Compounds [Chemical/Ingredient]
Tree Number: T6.2.28.9.1
database_cross_reference: MSH:D014220
database_cross_reference: NDFRT:N0000166784

Sucralfate
type: Class
subclass of: Organometallic Compounds
subclass of: Thioglycosides
MCID: MC00253863
PMOID: PMO:00017281
Subclass_of: Organometallic Compounds
Subclass_of: Thioglycosides
Synonym: Apo-sucralfate - Tab 1g
Synonym: Dom-sucralfate
Synonym: Hexadeca-μ-hydroxytetracosahydroxy[μ8-[1,3,4,6-tetra-O-sulfo-β-Dfructofuranosyl-α-D-glucopyranoside tetrakis(hydrogen sulfato)8-)]]hexadecaaluminum
Synonym: Nu-sucralfate - Tab 1gm
Synonym: PMS-sucralfate
Synonym: Sucralfate-1 - Tab 1g
Synonym: Sucralfato
Synonym: Sucramal
Synonym: Sucraxol
Synonym: Sulcrate
Tree Number: T6.2.28.10
Tree Number: T6.2.32.18.3
database_cross_reference: DRUGBANK:DB00364
database_cross_reference: MSH:D013392

Tetraethyl Lead
type: Class
subclass of: Organometallic Compounds
MCID: MC00012650
PMOID: PMO:00017282
Subclass_of: Organometallic Compounds
Synonym: Lead tetraethyl
Synonym: Lead tetraethyl (substance)
Synonym: Lead, Tetraethyl
Synonym: Plumbane, tetraethyl-
Synonym: Tetraethyl Lead [Chemical/Ingredient]
Synonym: Tetraethyl lead
Synonym: Tetraethyllead
Tree Number: T6.2.28.11
database_cross_reference: LCH_NW:sh87006520
database_cross_reference: LNC:LP19236-6
database_cross_reference: LNC:MTHU007731
database_cross_reference: MSH:D013756
database_cross_reference: NDFRT:N0000166766
database_cross_reference: RCD:XaD1n
database_cross_reference: SNM:E-5181
database_cross_reference: SNMI:C-13216
database_cross_reference: SNOMEDCT_US:111073002

Organotechnetium Compounds
type: Class
subclass of: Organometallic Compounds
MCID: MC00009235
PMOID: PMO:00017283
Subclass_of: Organometallic Compounds
Synonym: Compounds, Organotechnetium
Synonym: ORGANOTECHNETIUM CPDS
Synonym: Organotechnetium Compounds [Chemical/Ingredient]
Tree Number: T6.2.28.13
database_cross_reference: MSH:D015609
database_cross_reference: NDFRT:N0000008079

Technetium Tc 99m Aggregated Albumin
type: Class
subclass of: Organotechnetium Compounds
subclass of: PMO:00021885
MCID: MC00012576
PMOID: PMO:00017284
Subclass_of: Albumins
Subclass_of: Organotechnetium Compounds
Synonym: 99m-Tc-HSA
Synonym: 99mTc-HSA
Synonym: Albumin Colloid, Technetium-99m
Synonym: Colloid, Tc 99m-Albumin
Synonym: Colloid, Technetium-99m Albumin
Synonym: TC ALBUMIN COLLOID 099M
Synonym: TC HSA
Synonym: TECHNETIUM TC AGGREGATED ALBUMIN 099M
Synonym: TECHNETIUM TC-99M ALBUMIN AGGREGATED
Synonym: Tc 99m Albumin Colloid
Tree Number: T6.10.3.7.9
Tree Number: T6.2.28.13.1
database_cross_reference: LNC:LP208686-8
database_cross_reference: MEDCIN:224730
database_cross_reference: MSH:D013668
database_cross_reference: NCI:C87398
database_cross_reference: NCI_FDA:Z8E46IA45W
database_cross_reference: NDFRT:N0000169503
database_cross_reference: SNMI:C-B1200
database_cross_reference: SNOMEDCT_US:85693008

Technetium Tc 99m Medronate
type: Class
subclass of: Organotechnetium Compounds
MCID: MC00012577
PMOID: PMO:00017285
Subclass_of: Organotechnetium Compounds
Synonym: (99m)Tc-Medronate
Synonym: 99m Tc medronate
Synonym: 99m Tc-medronate
Synonym: 99mTc Methylene Diphosphonate
Synonym: 99mTc medronate
Synonym: 99mTc-MDP
Synonym: 99mTc-Methylene Diphosphonate
Synonym: 99mTc-medronate
Synonym: 99mtc-mdp
Synonym: Diphosphonate, 99mTc-Methylene
Tree Number: T6.2.28.13.2
database_cross_reference: CHV:0000012059
database_cross_reference: DRUGBANK:DB09138
database_cross_reference: LNC:LP208690-0
database_cross_reference: MSH:D013669
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:X89XV46R07
database_cross_reference: NCI:C67060
database_cross_reference: NCI_FDA:X89XV46R07
database_cross_reference: NDFRT:N0000166767
database_cross_reference: RXNORM:1488818
database_cross_reference: SNMI:C-B1218
database_cross_reference: SNOMEDCT_US:96390006

Technetium Tc 99m Mertiatide
type: Class
subclass of: Organotechnetium Compounds
subclass of: PMO:00021376
MCID: MC00046569
PMOID: PMO:00017286
Subclass_of: Oligopeptides
Subclass_of: Organotechnetium Compounds
Synonym: 99m Mercaptoacetylglycyl-glycyl-glycine, Technetium
Synonym: 99m Mertiatide, Tc
Synonym: 99mTc MAG3
Synonym: 99mTc Mercaptoacetyltriglycine
Synonym: 99mTc-MAG3
Synonym: 99mTc-Mercaptoacetyltriglycine
Synonym: Disodium (N-(N-(N-(Mercaptoacetyl)Glycyl)Glycyl)Glycinato(5-)-N,N',N'',S)-Oxo((Sup 99m)Tc)
Synonym: Mercaptoacetylglycyl-glycyl-glycine, Technetium 99m
Synonym: Mertiatide, Tc 99m
Synonym: TC MAG 099M 03
Tree Number: T6.10.2.13.26
Tree Number: T6.2.28.13.5
database_cross_reference: ATC:V09CA03
database_cross_reference: MSH:D017263
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87404
database_cross_reference: NCI_FDA:36ITO9SKQJ
database_cross_reference: NDFRT:N0000170314
database_cross_reference: SNOMEDCT_US:438296008

Organogold Compounds
type: Class
subclass of: Organometallic Compounds
MCID: MC00540800
PMOID: PMO:00017287
Subclass_of: Organometallic Compounds
Synonym: Compounds, Organogold
Synonym: ORGANOGOLD CPDS
Synonym: Organogold Compounds [Chemical/Ingredient]
Synonym: Organogold compounds
Tree Number: T6.2.28.15
database_cross_reference: LCH_NW:sh85095549
database_cross_reference: MSH:D050607
database_cross_reference: NDFRT:N0000166781

Aurothioglucose
type: Class
subclass of: Organogold Compounds
MCID: MC00005790
PMOID: PMO:00017288
Subclass_of: Organogold Compounds
Synonym: (1-Thio-D-Glucopyranosato)Gold
Synonym: AUROTHIOGLUCOSE
Synonym: Aurothioglucose (substance)
Synonym: Aurothioglucose [Chemical/Ingredient]
Synonym: Gold Thioglucose
Synonym: Gold thioglucose
Synonym: Gold, (1-Thio-D-Glucopyranosato)-
Synonym: Gold, (1-thio-D-glucopyranosato-O2,S1)-
Synonym: Solganal Inj 50mg/ml
Synonym: Thioglucose, Gold
Tree Number: T6.2.28.15.1
database_cross_reference: ATC:M01CB04
database_cross_reference: CHV:0000005646
database_cross_reference: CSP:1439-4941
database_cross_reference: DRUGBANK:DB09121
database_cross_reference: MMSL:4232
database_cross_reference: MMSL:d00820
database_cross_reference: MSH:D006051
database_cross_reference: NCI:C87435
database_cross_reference: NCI_FDA:2P2V9Q0E78
database_cross_reference: NDDF:002395
database_cross_reference: NDFRT:N0000006013
database_cross_reference: NDFRT:N0000147107
database_cross_reference: RXNORM:4980
database_cross_reference: SNM:E-8961
database_cross_reference: SNMI:C-B8212
database_cross_reference: SNOMEDCT_US:21880003
database_cross_reference: VANDF:4018804

Organophosphorus Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00009233
PMOID: PMO:00017291
Subclass_of: Organic Chemicals
Synonym: 221 ORGANIC PHOSPHORUS COMPOUNDS
Synonym: Compounds, Organophosphorus
Synonym: ORGANIC PHOSPHORUS COMPOUNDS
Synonym: ORGANOPHOSPHORUS CPDS
Synonym: Organic Phosphorus Compounds
Synonym: Organic phosphorus compound
Synonym: Organic phosphorus compound (substance)
Synonym: Organic phosphorus compound, NOS
Synonym: Organophosphorus Compounds [Chemical/Ingredient]
Synonym: Organophosphorus compound
Tree Number: T6.2.29
database_cross_reference: AOD:0000020597
database_cross_reference: CHV:0000009028
database_cross_reference: LCH:U003379
database_cross_reference: LCH_NW:sh85095568
database_cross_reference: MSH:D009943
database_cross_reference: NDFRT:N0000007684
database_cross_reference: RCD:Xa0XD
database_cross_reference: SNM:E-5880
database_cross_reference: SNM:U000141
database_cross_reference: SNMI:C-22100
database_cross_reference: SNOMEDCT_US:50352000

Organothiophosphorus Compounds
type: Class
subclass of: Sulfur Compounds
subclass of: Organophosphorus Compounds
MCID: MC00009236
PMOID: PMO:00017292
Subclass_of: Organophosphorus Compounds
Subclass_of: Sulfur Compounds
Synonym: Compounds, Organothiophosphorus
Synonym: ORGANOTHIOPHOSPHORUS CPDS
Synonym: Organothiophosphorus Compounds [Chemical/Ingredient]
Tree Number: T6.2.29.1
Tree Number: T6.2.32.4
database_cross_reference: MSH:D009946
database_cross_reference: NDFRT:N0000007686

Organothiophosphonates
type: Class
subclass of: Organothiophosphorus Compounds
subclass of: Organophosphonates
MCID: MC00909588
PMOID: PMO:00017293
Subclass_of: Organophosphonates
Subclass_of: Organothiophosphorus Compounds
Synonym: Organothiophosphonates [Chemical/Ingredient]
Tree Number: T6.2.29.1.1
Tree Number: T6.2.29.6.9
Tree Number: T6.2.32.4.1
database_cross_reference: MSH:D063085
database_cross_reference: NDFRT:N0000185714

Organothiophosphates
type: Class
subclass of: Organothiophosphorus Compounds
subclass of: Organophosphates
MCID: MC00909590
PMOID: PMO:00017297
Subclass_of: Organophosphates
Subclass_of: Organothiophosphorus Compounds
Synonym: Organothiophosphates [Chemical/Ingredient]
Tree Number: T6.2.29.1.2
Tree Number: T6.2.29.5.13
Tree Number: T6.2.32.4.2
database_cross_reference: MSH:D063086
database_cross_reference: NDFRT:N0000185715

Fosinopril
type: Class
subclass of: Phosphinic Acids
MCID: MC00050511
PMOID: PMO:00017315
Subclass_of: Phosphinic Acids
Synonym: (2S,4S)-4-Cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
Synonym: (2S,4S)-4-Cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
Synonym: (S)-4-Cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
Synonym: Acecor
Synonym: Apo-fosinopril
Synonym: Ava-fosinopril
Synonym: FOSINOPRIL
Synonym: FOSINOPRIL Na
Synonym: Fosenopril
Synonym: Fosinopril (product)
Tree Number: T6.2.29.3.1
database_cross_reference: ATC:C09AA09
database_cross_reference: CHV:0000016283
database_cross_reference: DRUGBANK:DB00492
database_cross_reference: LNC:LP171400-7
database_cross_reference: MEDCIN:340413
database_cross_reference: MMSL:d00242
database_cross_reference: MSH:D017328
database_cross_reference: MTHSPL:R43D2573WO
database_cross_reference: NCI:C65761
database_cross_reference: NCI_FDA:R43D2573WO
database_cross_reference: NDDF:004501
database_cross_reference: NDFRT:N0000006296
database_cross_reference: NDFRT:N0000148247
database_cross_reference: RCD:x01Qf
database_cross_reference: RXNORM:50166
database_cross_reference: SNOMEDCT_US:108569005
database_cross_reference: SNOMEDCT_US:372510000
database_cross_reference: USPMG:MTHU001026
database_cross_reference: VANDF:4020531

Organophosphates
type: Class
subclass of: Organophosphorus Compounds
MCID: MC00010148
PMOID: PMO:00017316
Subclass_of: Organophosphorus Compounds
Synonym: Acid Esters, Phosphoric
Synonym: Esters, Phosphoric Acid
Synonym: ORGANOPHOSPHATE
Synonym: Organic Phosphate
Synonym: Organic Phosphates
Synonym: Organic phosphate
Synonym: Organic phosphate, NOS
Synonym: Organophosphate
Synonym: Organophosphate, NOS
Synonym: PHOSPHATES ORG
Tree Number: T6.2.29.5
database_cross_reference: CCPSS:0045165
database_cross_reference: CHV:0000009674
database_cross_reference: CSP:2283-3743
database_cross_reference: DRUGBANK:DB09449
database_cross_reference: MSH:D010755
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94713
database_cross_reference: NCI_NCI-GLOSS:CDR0000476349
database_cross_reference: RCD:Xa859
database_cross_reference: SNM:E-5880
database_cross_reference: SNMI:C-22100
database_cross_reference: SNOMEDCT_US:301785006
database_cross_reference: SNOMEDCT_US:50352000

Chlorfenvinphos
type: Class
subclass of: Organophosphates
MCID: MC00002642
PMOID: PMO:00017317
Subclass_of: Organophosphates
Synonym: Chlorfenvinphos (substance)
Synonym: Chlorfenvinphos [Chemical/Ingredient]
Synonym: Chlorphenvinphos
Synonym: Clofenvinfos
Synonym: Phosphoric acid, 2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl ester
Tree Number: T6.2.29.5.2
database_cross_reference: LCH_NW:sh94007512
database_cross_reference: MSH:D002709
database_cross_reference: NDFRT:N0000166434
database_cross_reference: SNMI:C-23205
database_cross_reference: SNOMEDCT_US:30325000

Dichlorvos
type: Class
subclass of: Organophosphates
MCID: MC00003862
PMOID: PMO:00017318
Subclass_of: Organophosphates
Synonym: 0,0-Dimethyl 0-(2,2-dichlorovinyl) phosphate
Synonym: 0,0-Dimethyl 0-(2,2-dichlorvinyl) phosphate
Synonym: 2,2-Dichlorovinyl dimethyl phosphate
Synonym: DDVP
Synonym: DICHLORVOS
Synonym: Dichlofos
Synonym: Dichlorophos
Synonym: Dichlorvos (substance)
Synonym: Dichlorvos [Chemical/Ingredient]
Synonym: Dimethyl Dichlorovinyl Phosphate
Tree Number: T6.2.29.5.3
database_cross_reference: CHV:0000003889
database_cross_reference: CSP:2253-8157
database_cross_reference: LCH_NW:sh2011003123
database_cross_reference: LNC:LP18945-3
database_cross_reference: LNC:MTHU006965
database_cross_reference: MSH:D004006
database_cross_reference: NCI:C76871
database_cross_reference: NCI_FDA:7U370BPS14
database_cross_reference: NDFRT:N0000166418
database_cross_reference: RCD:XaD15
database_cross_reference: SNMI:C-23204
database_cross_reference: SNOMEDCT_US:57868002

Mevinphos
type: Class
subclass of: Organophosphates
MCID: MC00008269
PMOID: PMO:00017319
Subclass_of: Organophosphates
Synonym: 2-Butenoic acid, 3-((dimethoxyphosphinyl)oxy)-, methyl ester
Synonym: 2-Methoxycarbonyl-1-methylvinyl dimethyl phosphate
Synonym: Mevinphos (substance)
Synonym: Mevinphos [Chemical/Ingredient]
Tree Number: T6.2.29.5.5
database_cross_reference: LCH_NW:sh98007807
database_cross_reference: LNC:LP19569-0
database_cross_reference: LNC:MTHU009779
database_cross_reference: MSH:D008799
database_cross_reference: NDFRT:N0000166421
database_cross_reference: SNMI:C-23214
database_cross_reference: SNOMEDCT_US:63341008

Monocrotophos
type: Class
subclass of: Organophosphates
MCID: MC00008392
PMOID: PMO:00017320
Subclass_of: Organophosphates
Synonym: Monocrotophos [Chemical/Ingredient]
Synonym: Phosphoric acid, dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl ester, (E)-
Tree Number: T6.2.29.5.6
database_cross_reference: MSH:D008999
database_cross_reference: NDFRT:N0000166422

Naled
type: Class
subclass of: Organophosphates
MCID: MC00008644
PMOID: PMO:00017321
Subclass_of: Organophosphates
Synonym: Naled (substance)
Synonym: Naled [Chemical/Ingredient]
Synonym: Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester
Tree Number: T6.2.29.5.7
database_cross_reference: MSH:D009267
database_cross_reference: NDFRT:N0000166420
database_cross_reference: SNMI:C-23206
database_cross_reference: SNOMEDCT_US:81602004

Paraoxon
type: Class
subclass of: Organophosphates
MCID: MC00009717
PMOID: PMO:00017322
Subclass_of: Organophosphates
Synonym: Diethyl p Nitrophenyl Phosphate
Synonym: Diethyl p-nitrophenyl phosphate
Synonym: Diethyl p-nitrophenyl phosphate (substance)
Synonym: Diethyl-p-Nitrophenyl Phosphate
Synonym: Oxyparathion
Synonym: PARAOXON
Synonym: Paraoxon (substance)
Synonym: Paraoxon [Chemical/Ingredient]
Synonym: Phosphachole
Synonym: Phosphate, Diethyl-p-Nitrophenyl
Tree Number: T6.2.29.5.8
database_cross_reference: ATC:S01EB10
database_cross_reference: LNC:LP19570-8
database_cross_reference: LNC:MTHU009860
database_cross_reference: MSH:D010261
database_cross_reference: NCI:C99562
database_cross_reference: NCI_FDA:Q9CX8P80JW
database_cross_reference: NDFRT:N0000166435
database_cross_reference: SNM:E-5805
database_cross_reference: SNM:E-6362
database_cross_reference: SNMI:C-21971
database_cross_reference: SNMI:C-23173
database_cross_reference: SNOMEDCT_US:22194001
database_cross_reference: SNOMEDCT_US:81599009

Phosphamidon
type: Class
subclass of: Organophosphates
MCID: MC00010093
PMOID: PMO:00017323
Subclass_of: Organophosphates
Synonym: Phosphamidon [Chemical/Ingredient]
Synonym: Phosphoric acid, 2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl ester
Tree Number: T6.2.29.5.9
database_cross_reference: LCH_NW:sh94003428
database_cross_reference: MSH:D010707
database_cross_reference: NDFRT:N0000166436

Tetrachlorvinphos
type: Class
subclass of: Organophosphates
MCID: MC00012645
PMOID: PMO:00017324
Subclass_of: Organophosphates
Synonym: Phosphoric acid, 2-chloro-1-(2,4,5-trichlorophenyl)ethenyl dimethyl ester, (Z)-
Synonym: Stirofos
Synonym: Tetrachlorvinphos (substance)
Synonym: Tetrachlorvinphos [Chemical/Ingredient]
Tree Number: T6.2.29.5.11
database_cross_reference: MSH:D013751
database_cross_reference: NDFRT:N0000166432
database_cross_reference: SNOMEDCT_US:116550003

Organophosphonates
type: Class
subclass of: Organophosphorus Compounds
MCID: MC00725786
PMOID: PMO:00017325
Subclass_of: Organophosphorus Compounds
Synonym: Organophosphonates [Chemical/Ingredient]
Tree Number: T6.2.29.6
database_cross_reference: LNC:LP76353-9
database_cross_reference: MSH:D063065
database_cross_reference: NDFRT:N0000185672

Tenofovir
type: Class
subclass of: Organophosphonates
MCID: MC00136072
PMOID: PMO:00017326
Subclass_of: Organophosphonates
Synonym: (((1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy)methyl)phosphonic acid
Synonym: (R)-9-(2-Phosphonomethoxypropyl)adenine
Synonym: (R)-9-(2-phosphonomethoxypropyl)adenine
Synonym: (R)-9-(Phosphonomethoxypropyl)adenine
Synonym: (R)-PMPA
Synonym: 9(2-(phosphonomethoxy)propyl)adenine
Synonym: 9-(2-Phosphonomethoxypropyl)adenine
Synonym: 9-(2-Phosphonylmethoxypropyl)adenine
Synonym: 9-PMPA (tenofovir)
Synonym: Anh. tenofovir
Tree Number: T6.2.29.6.1
database_cross_reference: CHV:0000031931
database_cross_reference: DRUGBANK:DB00300
database_cross_reference: LNC:LP28761-2
database_cross_reference: LNC:MTHU015506
database_cross_reference: MMSL:d04774
database_cross_reference: MSH:D000068698
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:99YXE507IL
database_cross_reference: NCI:C29490
database_cross_reference: NCI_FDA:99YXE507IL
database_cross_reference: NDDF:009357
database_cross_reference: NDFRT:N0000010179
database_cross_reference: NDFRT:N0000148716
database_cross_reference: RXNORM:117466
database_cross_reference: SNOMEDCT_US:395264002
database_cross_reference: SNOMEDCT_US:422091007
database_cross_reference: USPMG:MTHU000668
database_cross_reference: VANDF:4021279

Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
type: Class
subclass of: Oxazines
subclass of: PMO:00024461
MCID: MC00791559
PMOID: PMO:00017327
Subclass_of: Drug Combinations
Subclass_of: Oxazines
Synonym: Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination [Chemical/Ingredient]
Synonym: Efavirenz/ Emtricitabine/ Tenofovir disoproxil fumarate
Synonym: efavirenz + emtricitabine + tenofovir disoproxil fumarate
Synonym: efavirenz + emtricitabine + tenofovir disoproxil fumarate (medication)
Synonym: efavirenz / emtricitabine / tenofovir disoproxil
Synonym: emtricitabine, tenofovir disoproxil and efavirenz
Tree Number: T6.15.3.1
Tree Number: T6.3.5.13.1
database_cross_reference: ATC:J05AR06
database_cross_reference: MEDCIN:303174
database_cross_reference: MSH:D000068257
database_cross_reference: NDFRT:N0000191977
database_cross_reference: RXNORM:1007761
database_cross_reference: USPMG:MTHU002684

Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC01007801
PMOID: PMO:00017328
Subclass_of: Drug Combinations
Synonym: Emtricitabine Tenofovir Disoproxil Fumarate Drug Combination
Synonym: Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination [Chemical/Ingredient]
Synonym: Emtricitabine-Tenofovir Disoproxil Fumarate Drug Combination
Tree Number: T6.15.3.13
database_cross_reference: MSH:D000069480
database_cross_reference: NDFRT:N0000191997

Aminoethylphosphonic Acid
type: Class
subclass of: Organophosphonates
MCID: MC00000757
PMOID: PMO:00017329
Subclass_of: Organophosphonates
Synonym: 2 Aminoethylphosphonic Acid
Synonym: 2-Aminoethylphosphonic Acid
Synonym: AMINOETHYLPHOSPHONIC ACID 02
Synonym: Acid, 2-Aminoethylphosphonic
Synonym: Acid, Aminoethylphosphonic
Synonym: Aminoethylphosphonic Acid [Chemical/Ingredient]
Synonym: Ciliatine
Synonym: Phosphonic acid, (2-aminoethyl)-
Tree Number: T6.2.29.6.2
database_cross_reference: MSH:D000615
database_cross_reference: NDFRT:N0000166437

Armin
type: Class
subclass of: Organophosphonates
MCID: MC00001234
PMOID: PMO:00017330
Subclass_of: Organophosphonates
Synonym: Armin [Chemical/Ingredient]
Synonym: Armine
Synonym: Ethyl-p-Nitrophenyl Ethylphosphonate
Tree Number: T6.2.29.6.3
database_cross_reference: MSH:D001138
database_cross_reference: NDFRT:N0000166430

Diphosphonates
type: Class
subclass of: Organophosphonates
MCID: MC00004013
PMOID: PMO:00017331
Subclass_of: Organophosphonates
Synonym: Biphosphonate
Synonym: Biphosphonates
Synonym: Bisphosphonates
Synonym: Diphosphonate
Synonym: Diphosphonate (product)
Synonym: Diphosphonate (substance)
Synonym: Diphosphonate, NOS
Synonym: Diphosphonates [Chemical/Ingredient]
Synonym: biphosphonate
Synonym: biphosphonates
Tree Number: T6.2.29.6.4
database_cross_reference: CHV:0000003985
database_cross_reference: CSP:2297-4218
database_cross_reference: LCH:U001406
database_cross_reference: LCH_NW:sh85038146
database_cross_reference: MEDCIN:133182
database_cross_reference: MEDCIN:40533
database_cross_reference: MSH:D004164
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C443
database_cross_reference: NCI_NCI-GLOSS:CDR0000044817
database_cross_reference: NCI_NCI-GLOSS:CDR0000044818
database_cross_reference: NDFRT:N0000007707
database_cross_reference: RCD:fo...
database_cross_reference: SNMI:C-71810
database_cross_reference: SNOMEDCT_US:372907000
database_cross_reference: SNOMEDCT_US:96281001

Fosfomycin
type: Class
subclass of: Organophosphonates
MCID: MC00005281
PMOID: PMO:00017336
Subclass_of: Organophosphonates
Synonym: (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid
Synonym: (1R,2S)-Epoxypropylphosphonic acid
Synonym: (2R-cis)-(3-Methyloxiranyl)phosphonic acid
Synonym: 1R-cis-(1,2-Epoxypropyl)phosphonic acid
Synonym: FCM
Synonym: FOSFOMYCIN
Synonym: Fosfocina
Synonym: Fosfomicina
Synonym: Fosfomycin (product)
Synonym: Fosfomycin (substance)
Tree Number: T6.2.29.6.5
database_cross_reference: ATC:J01XX01
database_cross_reference: CHV:0000005227
database_cross_reference: DRUGBANK:DB00828
database_cross_reference: LCH:U001861
database_cross_reference: LCH_NW:sh87002510
database_cross_reference: LNC:LP20811-3
database_cross_reference: LNC:MTHU012384
database_cross_reference: MEDCIN:340412
database_cross_reference: MMSL:d04106
database_cross_reference: MSH:D005578
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2N81MY12TE
database_cross_reference: NCI:C61772
database_cross_reference: NCI_FDA:2N81MY12TE
database_cross_reference: NDDF:004467
database_cross_reference: NDFRT:N0000007611
database_cross_reference: NDFRT:N0000022052
database_cross_reference: RCD:x01Hf
database_cross_reference: RXNORM:4550
database_cross_reference: SNOMEDCT_US:108720006
database_cross_reference: SNOMEDCT_US:372534005
database_cross_reference: USPMG:MTHU000238
database_cross_reference: VANDF:4024047

Trichlorfon
type: Class
subclass of: Organophosphonates
MCID: MC00013053
PMOID: PMO:00017337
Subclass_of: Organophosphonates
Synonym: Chlorofos
Synonym: Chlorophos
Synonym: Metrifonate
Synonym: Metriphonate
Synonym: Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester
Synonym: TRICHLORFON
Synonym: Trichlorfon (substance)
Synonym: Trichlorfon [Chemical/Ingredient]
Synonym: Trichlorphon
Synonym: metrifonate
Tree Number: T6.2.29.6.7
database_cross_reference: ATC:P02BB01
database_cross_reference: CHV:0000012527
database_cross_reference: MEDCIN:40415
database_cross_reference: MSH:D014236
database_cross_reference: MTHSPL:DBF2DG4G2K
database_cross_reference: NCI:C84225
database_cross_reference: NCI_FDA:DBF2DG4G2K
database_cross_reference: NDDF:005474
database_cross_reference: NDFRT:N0000166428
database_cross_reference: RXNORM:1000581
database_cross_reference: SNMI:C-23158
database_cross_reference: SNOMEDCT_US:49849004

Organofluorophosphonates
type: Class
subclass of: Organophosphonates
MCID: MC00909587
PMOID: PMO:00017338
Subclass_of: Organophosphonates
Synonym: Organofluorophosphonates [Chemical/Ingredient]
Tree Number: T6.2.29.6.8
database_cross_reference: MSH:D063066
database_cross_reference: NDFRT:N0000185713

Hempa
type: Class
subclass of: Phosphoramides
MCID: MC00006115
PMOID: PMO:00017342
Subclass_of: Phosphoramides
Synonym: ENT-50882
Synonym: HMPA
Synonym: Hempa [Chemical/Ingredient]
Synonym: Hexametapol
Synonym: Hexamethylphosphamide
Synonym: Hexamethylphosphoramide
Synonym: Hexamethylphosphoric Triamide
Synonym: Hexamethylphosphorotriamide
Synonym: Phosphoric triamide, hexamethyl-
Synonym: Phosphoryl Hexamethyltriamide
Tree Number: T6.2.29.7.1
database_cross_reference: CHV:0000006029
database_cross_reference: LNC:LP34813-3
database_cross_reference: LNC:MTHU017630
database_cross_reference: MSH:D006492
database_cross_reference: NCI:C44390
database_cross_reference: NDFRT:N0000166438

Tetraisopropylpyrophosphamide
type: Class
subclass of: Phosphoramides
MCID: MC00012665
PMOID: PMO:00017343
Subclass_of: Phosphoramides
Synonym: Diphosphoramide, N,N',N'',N'''-tetrakis(1-methylethyl)-
Synonym: Iso OMPA
Synonym: Iso-OMPA
Synonym: Tetraisopropylpyrophosphamide [Chemical/Ingredient]
Tree Number: T6.2.29.7.3
database_cross_reference: MSH:D013770
database_cross_reference: NDFRT:N0000166431

Thiotepa
type: Class
subclass of: Phosphoramides
MCID: MC00012723
PMOID: PMO:00017344
Subclass_of: Phosphoramides
Synonym: 1,1',1"-phosphinothioylidynetrisaziridine
Synonym: 1,1',1''-Phosphinothioyldynetrisaziridine
Synonym: 1,1',1''-Phosphinothioylidynetrisaziridine
Synonym: Aziridine, 1,1',1''-phosphinothioylidynetris-
Synonym: N,N', N''-Triethylenethiophosphoramide
Synonym: N,N',N''-triethylenethiophosphoramide
Synonym: TESPA
Synonym: THIOTEPA
Synonym: TSPA
Synonym: Thio Tepa
Tree Number: T6.2.29.7.4
database_cross_reference: ATC:L01AC01
database_cross_reference: CHV:0000012183
database_cross_reference: CSP:0315-3511
database_cross_reference: DRUGBANK:DB04572
database_cross_reference: MEDCIN:40525
database_cross_reference: MMSL:2134
database_cross_reference: MMSL:5573
database_cross_reference: MMSL:d00390
database_cross_reference: MSH:D013852
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:905Z5W3GKH
database_cross_reference: NCI:C875
database_cross_reference: NCI_DCP:00340
database_cross_reference: NCI_DTP:NSC0006396
database_cross_reference: NCI_FDA:905Z5W3GKH
database_cross_reference: NCI_NCI-GLOSS:CDR0000045603
database_cross_reference: NDDF:002637
database_cross_reference: NDFRT:N0000007190
database_cross_reference: NDFRT:N0000146261
database_cross_reference: PDQ:CDR0000042933
database_cross_reference: RCD:h1c..
database_cross_reference: RXNORM:10473
database_cross_reference: SNM:E-8337
database_cross_reference: SNMI:C-78210
database_cross_reference: SNOMEDCT_US:387508004
database_cross_reference: SNOMEDCT_US:88997008
database_cross_reference: VANDF:4017910

Quinones
type: Class
subclass of: Organic Chemicals
MCID: MC00011078
PMOID: PMO:00017345
Subclass_of: Organic Chemicals
Synonym: Benzoquinone Compound
Synonym: Quinone Compound
Synonym: Quinones [Chemical/Ingredient]
Synonym: quinone
Tree Number: T6.2.30
database_cross_reference: CSP:2532-2960
database_cross_reference: MSH:D011809
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C796
database_cross_reference: NDFRT:N0000008181

Atovaquone
type: Class
subclass of: Naphthoquinones
MCID: MC00064572
PMOID: PMO:00017346
Subclass_of: Naphthoquinones
Synonym: 2-(4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone
Synonym: 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone
Synonym: 2-(trans-4-(P-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone
Synonym: 3-(4-(4-chlorophenyl)cyclohexyl)-4-hydroxy-naphthalene-1,2-dione
Synonym: ATOVAQUONE
Synonym: Atovaquone (product)
Synonym: Atovaquone (substance)
Synonym: Atovaquone - chemical
Synonym: Atovaquone - chemical (substance)
Synonym: Atovaquone [Chemical/Ingredient]
Tree Number: T6.2.30.2.4
database_cross_reference: ATC:P01AX06
database_cross_reference: CHV:0000018072
database_cross_reference: CSP:4007-0009
database_cross_reference: DRUGBANK:DB01117
database_cross_reference: LNC:LP94829-6
database_cross_reference: LNC:MTHU031993
database_cross_reference: MEDCIN:48401
database_cross_reference: MMSL:213467
database_cross_reference: MMSL:4227
database_cross_reference: MMSL:d01120
database_cross_reference: MSH:D053626
database_cross_reference: MTHSPL:Y883P1Z2LT
database_cross_reference: NCI:C28838
database_cross_reference: NCI_FDA:Y883P1Z2LT
database_cross_reference: NDDF:004112
database_cross_reference: NDFRT:N0000005848
database_cross_reference: NDFRT:N0000148284
database_cross_reference: RCD:ey2..
database_cross_reference: RXNORM:60212
database_cross_reference: SNOMEDCT_US:108718008
database_cross_reference: SNOMEDCT_US:386899002
database_cross_reference: SNOMEDCT_US:391793007
database_cross_reference: USPMG:MTHU000565
database_cross_reference: VANDF:4020594

Benzoquinones
type: Class
subclass of: Quinones
MCID: MC00041000
PMOID: PMO:00017347
Subclass_of: Quinones
Synonym: Benzodiones
Synonym: Benzoquinones [Chemical/Ingredient]
Tree Number: T6.2.30.3
database_cross_reference: MSH:D016227
database_cross_reference: NDFRT:N0000011447

Carbazilquinone
type: Class
subclass of: Benzoquinones
MCID: MC00002212
PMOID: PMO:00017348
Subclass_of: Benzoquinones
Synonym: 2,5-Cyclohexadiene-1,4-dione, 2-(2-((aminocarbonyl)oxy)-1-methoxyethyl)-3,6-bis(1-aziridinyl)-5-methyl-
Synonym: CARBOQUONE
Synonym: Carbazilquinone [Chemical/Ingredient]
Synonym: Carboquinone
Synonym: Carboquone
Synonym: carboquone
Tree Number: T6.2.30.3.1
database_cross_reference: ATC:L01AC03
database_cross_reference: MSH:D002225
database_cross_reference: NCI:C342
database_cross_reference: NCI_DTP:NSC0000662
database_cross_reference: NCI_FDA:1CB0HBT12C
database_cross_reference: NDFRT:N0000167146

Chloranil
type: Class
subclass of: Benzoquinones
MCID: MC00002636
PMOID: PMO:00017349
Subclass_of: Benzoquinones
Synonym: 2,3,5,6-Tetrachloro-1,4-benzoquinone
Synonym: 2,5-Cyclohexadiene-1,4-dione, 2,3,5,6-tetrachloro-
Synonym: Chloranil [Chemical/Ingredient]
Synonym: Tetrachloro 1,4 benzoquinone
Synonym: Tetrachloro-1, 4-benzoquinone
Synonym: Tetrachloro-1,4- benzoquinone
Synonym: Tetrachloro-1,4- benzoquinone (substance)
Synonym: Tetrachloro-1,4-benzoquinone
Tree Number: T6.2.30.3.2
database_cross_reference: LCH_NW:sh93007807
database_cross_reference: MSH:D002703
database_cross_reference: NDFRT:N0000166803
database_cross_reference: SNM:E-5585
database_cross_reference: SNMI:C-21129
database_cross_reference: SNOMEDCT_US:82205007

Dibromothymoquinone
type: Class
subclass of: Benzoquinones
MCID: MC00003846
PMOID: PMO:00017350
Subclass_of: Benzoquinones
Synonym: 2,5 Dibromo 3 methyl 6 isopropyl p benzoquinone
Synonym: 2,5-Cyclohexadiene-1,4-dione, 2,5-dibromo-3-methyl-6-(1-methylethyl)-
Synonym: 2,5-DIBROMO-3-ISOPROPYL-6-METHYLBENZO-1,4-QUINONE
Synonym: 2,5-Dibromo-3-isopropyl-6-methylbenzoquinone
Synonym: 2,5-Dibromo-3-methyl-6-isopropyl-p-benzoquinone
Synonym: 2,5-Dibromo-6-isopropyl-3-methyl-1,4-benzoquinone
Synonym: DBMIB
Synonym: Dibromothymoquinone [Chemical/Ingredient]
Tree Number: T6.2.30.3.3
database_cross_reference: DRUGBANK:DB04646
database_cross_reference: MSH:D003991
database_cross_reference: NDFRT:N0000166804

Plastoquinone
type: Class
subclass of: Benzoquinones
MCID: MC00010307
PMOID: PMO:00017351
Subclass_of: Benzoquinones
Synonym: 2,5-Cyclohexadiene-1,4-dione, 2,3-dimethyl-5-(3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaenyl)-, (all-E)-
Synonym: Plastoquinone 9
Synonym: Plastoquinone [Chemical/Ingredient]
Synonym: Plastoquinone-9
Synonym: plastoquinone
Tree Number: T6.2.30.3.4
database_cross_reference: CSP:2876-1788
database_cross_reference: MSH:D010971
database_cross_reference: NDFRT:N0000166802

Ubiquinone
type: Class
subclass of: Benzoquinones
subclass of: Coenzymes
MCID: MC00013277
PMOID: PMO:00017352
Subclass_of: Benzoquinones
Subclass_of: Coenzymes
Synonym: 2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecanyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Synonym: Coenzyme Q
Synonym: Ubiquinone [Chemical/Ingredient]
Synonym: Ubiquinones
Synonym: coenzyme Q
Synonym: coenzyme q
Synonym: coenzyme-Q
Synonym: coenzyme-q
Synonym: dietary supplements ubiquinone
Synonym: ubiquinone
Tree Number: T6.2.30.3.5
Tree Number: T6.7.1.12
database_cross_reference: AOD:0000018591
database_cross_reference: CHV:0000012694
database_cross_reference: CSP:2532-4451
database_cross_reference: LCH:U004834
database_cross_reference: LCH_NW:sh85139235
database_cross_reference: MEDCIN:48437
database_cross_reference: MMSL:37841
database_cross_reference: MMSL:d04523
database_cross_reference: MSH:D014451
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C916
database_cross_reference: NCI_NCI-GLOSS:CDR0000347386
database_cross_reference: NDDF:012958
database_cross_reference: NDFRT:N0000011446
database_cross_reference: PDQ:CDR0000039187
database_cross_reference: RXNORM:10975
database_cross_reference: SNOMEDCT_US:412130008

Indolequinones
type: Class
subclass of: Quinones
MCID: MC00421707
PMOID: PMO:00017353
Subclass_of: Quinones
Synonym: Indole Quinones
Synonym: Indole-Quinones
Synonym: Indolequinones [Chemical/Ingredient]
Synonym: Indoloquinones
Tree Number: T6.2.30.4
database_cross_reference: MSH:D045563
database_cross_reference: NDFRT:N0000011416

Mitomycins
type: Class
subclass of: Indolequinones
subclass of: Azirines
MCID: MC00008353
PMOID: PMO:00017354
Subclass_of: Azirines
Subclass_of: Indolequinones
Synonym: Mitomycin Antineoplastic Antibiotic
Synonym: Mitomycins [Chemical/Ingredient]
Synonym: mitomycin
Tree Number: T6.2.30.4.1
Tree Number: T6.3.5.4.2
database_cross_reference: CHV:0000008186
database_cross_reference: CSP:0201-3475
database_cross_reference: MSH:D008937
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C663
database_cross_reference: NCI_NCI-GLOSS:CDR0000045538
database_cross_reference: NDFRT:N0000007855

Pyrroloiminoquinones
type: Class
subclass of: Indolequinones
MCID: MC00516341
PMOID: PMO:00017357
Subclass_of: Indolequinones
Synonym: Pyrrolo Iminoquinones
Synonym: Pyrrolo-Iminoquinones
Synonym: Pyrroloiminoquinones [Chemical/Ingredient]
Tree Number: T6.2.30.4.2
database_cross_reference: MSH:D047608
database_cross_reference: NDFRT:N0000166972

Semicarbazides
type: Class
subclass of: Organic Chemicals
MCID: MC00011726
PMOID: PMO:00017358
Subclass_of: Organic Chemicals
Synonym: Semicarbazides [Chemical/Ingredient]
Tree Number: T6.2.31
database_cross_reference: MSH:D012663
database_cross_reference: NDFRT:N0000166845

Diphenylcarbazide
type: Class
subclass of: Semicarbazides
MCID: MC00004010
PMOID: PMO:00017359
Subclass_of: Semicarbazides
Synonym: 1,5 Diphenylcarbazide
Synonym: 1,5-Diphenylcarbazide
Synonym: Carbonic dihydrazide, 2,2'-diphenyl-
Synonym: DIPHENYLCARBAZIDE 01 05
Synonym: Diphenylcarbazide [Chemical/Ingredient]
Synonym: S Diphenylcarbazide
Synonym: S-Diphenylcarbazide
Tree Number: T6.2.31.1
database_cross_reference: MSH:D004160
database_cross_reference: NDFRT:N0000166846

Semicarbazones
type: Class
subclass of: Semicarbazides
MCID: MC00011727
PMOID: PMO:00017360
Subclass_of: Semicarbazides
Synonym: Semicarbazone
Synonym: Semicarbazone (substance)
Synonym: Semicarbazones [Chemical/Ingredient]
Synonym: semicarbazone
Tree Number: T6.2.31.2
database_cross_reference: CHV:0000011185
database_cross_reference: MSH:D012664
database_cross_reference: NDFRT:N0000166847
database_cross_reference: SNOMEDCT_US:422803002

Thiosemicarbazones
type: Class
subclass of: Sulfur Compounds
subclass of: Semicarbazones
MCID: MC00012754
PMOID: PMO:00017361
Subclass_of: Semicarbazones
Subclass_of: Sulfur Compounds
Synonym: Thiosemicarbazone
Synonym: Thiosemicarbazone (substance)
Synonym: Thiosemicarbazones [Chemical/Ingredient]
Synonym: thiosemicarbazone
Synonym: thiosemicarbazones
Tree Number: T6.2.31.2.1
Tree Number: T6.2.32.23
database_cross_reference: CHV:0000012193
database_cross_reference: CSP:0316-5121
database_cross_reference: LCH_NW:sh93006562
database_cross_reference: MSH:D013882
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166848
database_cross_reference: SNOMEDCT_US:422638003

Methisazone
type: Class
subclass of: Thiosemicarbazones
MCID: MC00008187
PMOID: PMO:00017362
Subclass_of: Thiosemicarbazones
Synonym: 1-Methylisatin 3-thiosemicarbazone
Synonym: 1-Methylisatin beta-thiosemicarbazone
Synonym: 5,6-Dichloro-N-(1-methylethyl)-1-beta-L-ribofuranosyl-1H-
Synonym: Compound 33T57
Synonym: Hydrazinecarbothioamide, 2-(1,2-dihydro-1-methyl-2-oxo-3H-indol-3-ylidene)-
Synonym: Isatin, 1-methyl-, 3-(thiosemicarbazone)
Synonym: METHISAZONE
Synonym: Methisazone (substance)
Synonym: Methisazone - chemical
Synonym: Methisazone - chemical (substance)
Tree Number: T6.2.32.23.1
database_cross_reference: ATC:J05AA01
database_cross_reference: CHV:0000008039
database_cross_reference: LCH_NW:sh93006561
database_cross_reference: MSH:D008720
database_cross_reference: NCI:C77928
database_cross_reference: NCI_FDA:K3QML4J07E
database_cross_reference: NDFRT:N0000166961
database_cross_reference: SNM:E-7351
database_cross_reference: SNMI:C-55B70
database_cross_reference: SNOMEDCT_US:360195007
database_cross_reference: SNOMEDCT_US:47180000

Thioacetazone
type: Class
subclass of: Thiosemicarbazones
MCID: MC00012700
PMOID: PMO:00017363
Subclass_of: Thiosemicarbazones
Synonym: 4'-Formylacetanilide Thiosemicarbazone
Synonym: AMITHIOZONE
Synonym: Acetamide, N-(4-(((aminothioxomethyl)hydrazono)methyl)phenyl)-
Synonym: Amithiozone
Synonym: Thiacetazone
Synonym: Thibone
Synonym: Thioacetazon
Synonym: Thioacetazone [Chemical/Ingredient]
Synonym: Thioparamizone
Tree Number: T6.2.32.23.2
database_cross_reference: ATC:J04AK07
database_cross_reference: CHV:0000012171
database_cross_reference: DRUGBANK:DB12829
database_cross_reference: LNC:LP30490-4
database_cross_reference: LNC:MTHU015014
database_cross_reference: MSH:D013828
database_cross_reference: NCI:C85523
database_cross_reference: NCI:C90769
database_cross_reference: NCI_FDA:MMG78X7SSR
database_cross_reference: NDFRT:N0000166849

Amino Acids, Sulfur
type: Class
subclass of: Sulfur Compounds
subclass of: PMO:00021256
MCID: MC00000745
PMOID: PMO:00017364
Subclass_of: Amino Acids
Subclass_of: Sulfur Compounds
Synonym: Acids, Sulfur Amino
Synonym: Amino Acids, Sulfur [Chemical/Ingredient]
Synonym: Sulfur Amino Acids
Synonym: Sulfur amino acids
Synonym: Sulfur-bearing amino acid
Synonym: Sulfur-bearing amino acid (substance)
Synonym: Sulfur-bearing amino acid, NOS
Synonym: Sulphur-bearing amino acid
Synonym: sulfur amino acids
Synonym: sulfur aminoacid
Tree Number: T6.10.1.8
Tree Number: T6.2.32.1
database_cross_reference: AOD:0000020260
database_cross_reference: CSP:2842-6521
database_cross_reference: LCH_NW:sh85130369
database_cross_reference: MSH:D000603
database_cross_reference: NDFRT:N0000007836
database_cross_reference: SNMI:F-64590
database_cross_reference: SNOMEDCT_US:102751005

Cystathionine
type: Class
subclass of: Amino Acids, Sulfur
subclass of: PMO:00021283
subclass of: PMO:00021298
MCID: MC00003450
PMOID: PMO:00017365
Subclass_of: Amino Acids, Diamino
Subclass_of: Amino Acids, Dicarboxylic
Subclass_of: Amino Acids, Sulfur
Synonym: 2-Amino-4-(2-Amino-2-Carboxy-Ethyl) Thio-Butanoic Acid
Synonym: 2-Amino-4-[(2-Amino-2-Carboxyethyl)Sulfanyl]Butanoic Acid
Synonym: Cystathionine (substance)
Synonym: Cystathionine [Chemical/Ingredient]
Synonym: DL-Allocystathionine
Synonym: DL-Cystathionine
Synonym: Homocysteine, S-(2-Amino-2-Carboxyethyl)-
Synonym: L-Homocysteine, S-(2-amino-2-carboxyethyl)-, (R)-
Synonym: S-(2-Amino-2-Carboxyethyl)Homocysteine
Synonym: cystathionine
Tree Number: T6.10.1.5.4
Tree Number: T6.10.1.6.3
Tree Number: T6.10.1.8.1
Tree Number: T6.2.32.1.1
database_cross_reference: CHV:0000003545
database_cross_reference: CSP:2842-6521
database_cross_reference: LNC:LP15519-9
database_cross_reference: LNC:MTHU004101
database_cross_reference: MSH:D003540
database_cross_reference: NCI:C118875
database_cross_reference: NDFRT:N0000170287
database_cross_reference: RCD:X80HS
database_cross_reference: SNM:F-14370
database_cross_reference: SNMI:F-64170
database_cross_reference: SNOMEDCT_US:84035007

Cysteic Acid
type: Class
subclass of: Amino Acids, Sulfur
MCID: MC00003456
PMOID: PMO:00017366
Subclass_of: Amino Acids, Sulfur
Synonym: 3 Sulfoalanine
Synonym: 3-Sulfoalanine
Synonym: Acid, Cysteic
Synonym: Alanine, 3-sulfo-
Synonym: Cysteate
Synonym: Cysteic Acid [Chemical/Ingredient]
Synonym: Cysteic acid
Synonym: Cysteic acid (substance)
Synonym: SULFOALANINE 03
Synonym: beta Sulfoalanine
Tree Number: T6.10.1.8.2
Tree Number: T6.2.32.1.2
database_cross_reference: LNC:LP20850-1
database_cross_reference: LNC:MTHU012454
database_cross_reference: MSH:D003544
database_cross_reference: NDDF:006982
database_cross_reference: NDFRT:N0000170273
database_cross_reference: SNOMEDCT_US:709592008

Cysteine
type: Class
subclass of: Amino Acids, Sulfur
subclass of: Sulfhydryl Compounds
subclass of: PMO:00021323
MCID: MC00003457
PMOID: PMO:00017367
Subclass_of: Amino Acids, Neutral
Subclass_of: Amino Acids, Sulfur
Subclass_of: Sulfhydryl Compounds
Synonym: (2R)-2-amino-3-mercaptopropanoic acid
Synonym: (2R)-2-amino-3-sulfanylpropanoic acid
Synonym: (R)-2-Amino-3-mercaptopropanoic acid
Synonym: (R)-2-Amino-3-sulfanyl-propanoic acid
Synonym: Aminoderm Poudre
Synonym: CYSTEINE
Synonym: Cicatrin Powder
Synonym: Cys
Synonym: Cysteine (substance)
Synonym: Cysteine [Chemical/Ingredient]
Tree Number: T6.10.1.22.2
Tree Number: T6.10.1.8.3
Tree Number: T6.2.32.1.3
Tree Number: T6.2.32.6.1
database_cross_reference: AOD:0000020235
database_cross_reference: AOD:0000028889
database_cross_reference: CHV:0000003549
database_cross_reference: CSP:2842-6699
database_cross_reference: DRUGBANK:DB00151
database_cross_reference: FMA:82751
database_cross_reference: LNC:LP15521-5
database_cross_reference: LNC:MTHU009241
database_cross_reference: MMSL:11233
database_cross_reference: MMSL:7452
database_cross_reference: MMSL:d04181
database_cross_reference: MSH:D003545
database_cross_reference: MTHSPL:K848JZ4886
database_cross_reference: NCI:C29609
database_cross_reference: NCI_CRCH:C29609
database_cross_reference: NCI_FDA:K848JZ4886
database_cross_reference: NDDF:004536
database_cross_reference: NDFRT:N0000006029
database_cross_reference: NDFRT:N0000147794
database_cross_reference: NDFRT:N0000184609
database_cross_reference: PSY:12910
database_cross_reference: RCD:X807E
database_cross_reference: RCD:XaDdJ
database_cross_reference: RXNORM:3024
database_cross_reference: SNM:F-14380
database_cross_reference: SNMI:F-64180
database_cross_reference: SNOMEDCT_US:108949008
database_cross_reference: SNOMEDCT_US:312173000
database_cross_reference: SNOMEDCT_US:386942009
database_cross_reference: SNOMEDCT_US:5932006
database_cross_reference: VANDF:4019702
database_cross_reference: VANDF:4031437

Carbocysteine
type: Class
subclass of: PMO:00021298
MCID: MC00002225
PMOID: PMO:00017369
Subclass_of: Amino Acids, Dicarboxylic
Synonym: (L)-2-Amino-3-(carboxymethylthio)propionic acid
Synonym: (R)-S-(carboxymethyl)cysteine
Synonym: 3-(Carboxymethylthio)alanine
Synonym: Actithiol
Synonym: CARBOCYSTEINE
Synonym: Carbocisteine
Synonym: Carbocisteine (product)
Synonym: Carbocisteine (substance)
Synonym: Carbocysteine (product)
Synonym: Carbocysteine [Chemical/Ingredient]
Tree Number: T6.10.1.6.2
database_cross_reference: ATC:R05CB03
database_cross_reference: CHV:0000002388
database_cross_reference: DRUGBANK:DB04339
database_cross_reference: MEDCIN:197819
database_cross_reference: MMSL:26469
database_cross_reference: MMSL:d05062
database_cross_reference: MSH:D002233
database_cross_reference: MTHSPL:740J2QX53R
database_cross_reference: NCI:C83591
database_cross_reference: NCI_FDA:740J2QX53R
database_cross_reference: NDDF:003677
database_cross_reference: NDFRT:N0000170286
database_cross_reference: RCD:ce3..
database_cross_reference: RXNORM:2023
database_cross_reference: SNOMEDCT_US:320933002
database_cross_reference: SNOMEDCT_US:395842001

Selenocysteine
type: Class
subclass of: Organoselenium Compounds
MCID: MC00037562
PMOID: PMO:00017370
Subclass_of: Organoselenium Compounds
Synonym: 3 Selenylalanine
Synonym: 3-Selenyl-L-Alanine
Synonym: 3-Selenylalanine
Synonym: 3-selenyl-L-alanine
Synonym: L-Alanine, 3-selenyl-
Synonym: L-selenocysteine
Synonym: SELENOCYSTEINE
Synonym: SeC
Synonym: Selenium cysteine
Synonym: Selenocysteine [Chemical/Ingredient]
Tree Number: T6.2.35.2
database_cross_reference: DRUGBANK:DB02345
database_cross_reference: MSH:D017279
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:0CH9049VIS
database_cross_reference: NCI:C1223
database_cross_reference: NCI_FDA:0CH9049VIS
database_cross_reference: NDFRT:N0000170264
database_cross_reference: RXNORM:1549332

Ethionine
type: Class
subclass of: Amino Acids, Sulfur
MCID: MC00004776
PMOID: PMO:00017371
Subclass_of: Amino Acids, Sulfur
Synonym: Ethionine [Chemical/Ingredient]
Synonym: L-Homocysteine, S-ethyl-
Synonym: ethionine
Tree Number: T6.10.1.8.4
Tree Number: T6.2.32.1.4
database_cross_reference: CSP:2842-6521
database_cross_reference: MSH:D005001
database_cross_reference: NDFRT:N0000170272

Homocysteine
type: Class
subclass of: Amino Acids, Sulfur
PMOID: PMO:00017372
Subclass_of: Amino Acids, Sulfur
Tree Number: T6.10.1.8.5
Tree Number: T6.2.32.1.5

Homocystine
type: Class
subclass of: Amino Acids, Sulfur
subclass of: PMO:00021283
subclass of: PMO:00021298
MCID: MC00006377
PMOID: PMO:00017374
Subclass_of: Amino Acids, Diamino
Subclass_of: Amino Acids, Dicarboxylic
Subclass_of: Amino Acids, Sulfur
Synonym: Butanoic acid, 4,4'-dithiobis(2-amino)-
Synonym: Homocystine (substance)
Synonym: Homocystine [Chemical/Ingredient]
Synonym: L-Homocystine
Synonym: L-Homocystine (substance)
Synonym: homocystine
Synonym: homocystines
Tree Number: T6.10.1.5.8
Tree Number: T6.10.1.6.6
Tree Number: T6.10.1.8.6
Tree Number: T6.2.32.1.6
database_cross_reference: AOD:0000020258
database_cross_reference: CHV:0000006227
database_cross_reference: CSP:2842-7411
database_cross_reference: LNC:LP15641-1
database_cross_reference: LNC:LP69844-6
database_cross_reference: LNC:MTHU003093
database_cross_reference: MSH:D006711
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170289
database_cross_reference: RCD:X807M
database_cross_reference: RCD:XaDdP
database_cross_reference: SNM:F-14460
database_cross_reference: SNMI:F-64260
database_cross_reference: SNOMEDCT_US:26645004
database_cross_reference: SNOMEDCT_US:312179001

Tiopronin
type: Class
subclass of: Amino Acids, Sulfur
MCID: MC00008087
PMOID: PMO:00017375
Subclass_of: Amino Acids, Sulfur
Synonym: (2-Mercaptopropionyl)glycine
Synonym: 2 Mercaptopropionylglycine
Synonym: 2 Thiol propionamido acetic Acid
Synonym: 2 Thiolpropionamidoacetic Acid
Synonym: 2-Mercaptopropionylglycine
Synonym: 2-Thiol-propionamido-acetic Acid
Synonym: 2-Thiolpropionamidoacetic Acid
Synonym: Acid, 2-Thiol-propionamido-acetic
Synonym: Acid, 2-Thiolpropionamidoacetic
Synonym: Capen
Tree Number: T6.10.1.8.7
Tree Number: T6.2.32.1.7
database_cross_reference: ATC:G04BX16
database_cross_reference: CHV:0000007975
database_cross_reference: DRUGBANK:DB06823
database_cross_reference: MEDCIN:198799
database_cross_reference: MMSL:5587
database_cross_reference: MMSL:d01418
database_cross_reference: MSH:D008625
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:C5W04GO61S
database_cross_reference: NCI:C47758
database_cross_reference: NCI_FDA:C5W04GO61S
database_cross_reference: NDDF:002371
database_cross_reference: NDFRT:N0000006418
database_cross_reference: NDFRT:N0000147595
database_cross_reference: RXNORM:6765
database_cross_reference: SNOMEDCT_US:109106000
database_cross_reference: SNOMEDCT_US:397225004
database_cross_reference: VANDF:4019475

Methionine
type: Class
subclass of: Amino Acids, Sulfur
subclass of: PMO:00021308
subclass of: PMO:00021323
MCID: MC00008180
PMOID: PMO:00017376
Subclass_of: Amino Acids, Essential
Subclass_of: Amino Acids, Neutral
Subclass_of: Amino Acids, Sulfur
Synonym: (2S)-2-amino-4-(Methylsulfanyl)butanoic acid
Synonym: (S)-2-Amino-4-(methyl-sulfanyl)butanoic acid
Synonym: (S)-2-amino-4-(methylthio)butanoic acid
Synonym: (S)-2-amino-4-(methylthio)butyric acid
Synonym: (S)-methionine
Synonym: 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose
Synonym: 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix
Synonym: 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix
Synonym: 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex
Synonym: 2.75% Travas. Amino Acid InJ.W.elecw.25%dex
Tree Number: T6.10.1.22.4
Tree Number: T6.10.1.7.6
Tree Number: T6.10.1.8.8
Tree Number: T6.2.32.1.8
database_cross_reference: AOD:0000020229
database_cross_reference: AOD:0000028885
database_cross_reference: ATC:V03AB26
database_cross_reference: CHV:0000008038
database_cross_reference: CSP:2842-7856
database_cross_reference: DRUGBANK:DB00134
database_cross_reference: DRUGBANK:DB01646
database_cross_reference: FMA:82759
database_cross_reference: LCH:U002937
database_cross_reference: LCH_NW:sh85084391
database_cross_reference: LNC:LP15730-2
database_cross_reference: LNC:LP32571-9
database_cross_reference: LNC:LP70164-6
database_cross_reference: LNC:MTHU004104
database_cross_reference: MEDCIN:41193
database_cross_reference: MMSL:5074
database_cross_reference: MMSL:6044
database_cross_reference: MMSL:NOCODE
database_cross_reference: MMSL:d00489
database_cross_reference: MSH:D008715
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:AE28F7PNPL
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C29600
database_cross_reference: NCI_CRCH:C29600
database_cross_reference: NCI_DCP:01553
database_cross_reference: NCI_FDA:AE28F7PNPL
database_cross_reference: NDDF:002867
database_cross_reference: NDFRT:N0000007345
database_cross_reference: NDFRT:N0000146983
database_cross_reference: PSY:31130
database_cross_reference: RCD:XM0lD
database_cross_reference: RCD:XaDdU
database_cross_reference: RCD:dv2..
database_cross_reference: RXNORM:6837
database_cross_reference: SNM:F-14540
database_cross_reference: SNMI:F-64340
database_cross_reference: SNOMEDCT_US:108956002
database_cross_reference: SNOMEDCT_US:312184007
database_cross_reference: SNOMEDCT_US:386944005
database_cross_reference: SNOMEDCT_US:70288006
database_cross_reference: VANDF:4018672

N-Formylmethionine Leucyl-Phenylalanine
type: Class
subclass of: PMO:00021376
subclass of: PMO:00024374
MCID: MC00008612
PMOID: PMO:00017380
Subclass_of: Chemotactic Factors
Subclass_of: Oligopeptides
Synonym: FMLP
Synonym: FORMYLMETHIONINELEUCYLPHENYLALANINE N
Synonym: FORMYLMETHIONYLLEUCYLPHENYLALANINE N
Synonym: Formylmet Leu Phe
Synonym: Formylmet-Leu-Phe
Synonym: Formylmethionyl Leucyl Phenylalanine
Synonym: Formylmethionyl-Leucyl-Phenylalanine
Synonym: Formylmethionylleucylphenylalanine
Synonym: L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-
Synonym: Leucyl-Phenylalanine, N-Formylmethionine
Tree Number: T6.10.2.13.12
Tree Number: T6.13.5.4
database_cross_reference: CSP:1553-6622
database_cross_reference: CSP:2237-4858
database_cross_reference: MSH:D009240
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171252

Selenomethionine
type: Class
subclass of: Organoselenium Compounds
MCID: MC00011718
PMOID: PMO:00017382
Subclass_of: Organoselenium Compounds
Synonym: Butanoic acid, 2-amino-4-(methylseleno)-
Synonym: DL-Selenomethionine
Synonym: SELENOMETHIONINE
Synonym: SELENOMETHIONINE, DL-
Synonym: Selenium methionine
Synonym: Selenomethionine (substance)
Synonym: Selenomethionine [Chemical/Ingredient]
Synonym: selenomethionine
Tree Number: T6.2.35.1
database_cross_reference: AOD:0000020261
database_cross_reference: CHV:0000011167
database_cross_reference: CSP:2842-8123
database_cross_reference: DRUGBANK:DB11142
database_cross_reference: MSH:D012645
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:964MRK2PEL
database_cross_reference: NCI:C826
database_cross_reference: NCI_FDA:J9V40V4PKZ
database_cross_reference: NDDF:009044
database_cross_reference: NDFRT:N0000006108
database_cross_reference: RXNORM:9644
database_cross_reference: SNOMEDCT_US:710051007

Penicillamine
type: Class
subclass of: Amino Acids, Sulfur
MCID: MC00009807
PMOID: PMO:00017385
Subclass_of: Amino Acids, Sulfur
Synonym: (-)-penicillamine
Synonym: (S)-2-amino-3-mercapto-3-methylbutanoic acid
Synonym: (S)-3,3-dimethylcysteine
Synonym: (−)-penicillamine
Synonym: .beta.,.beta.-Dimethylcysteine
Synonym: 3-Mercapto-D-valine
Synonym: 3-mercapto-D-valine
Synonym: Alpha-amino-beta-methyl-beta-mercaptobutyric Acid
Synonym: Beta,Beta-dimethylcysteine
Synonym: Beta-thiovaline
Tree Number: T6.10.1.8.9
Tree Number: T6.2.32.1.9
database_cross_reference: AOD:0000020265
database_cross_reference: ATC:M01CC01
database_cross_reference: CHV:0000009415
database_cross_reference: CSP:2842-8301
database_cross_reference: DRUGBANK:DB00859
database_cross_reference: LCH:U003520
database_cross_reference: LCH_NW:sh85099401
database_cross_reference: MEDCIN:40655
database_cross_reference: MMSL:5243
database_cross_reference: MMSL:d00333
database_cross_reference: MSH:D010396
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:GNN1DV99GX
database_cross_reference: NCI:C729
database_cross_reference: NCI_DTP:NSC0081549
database_cross_reference: NCI_FDA:GNN1DV99GX
database_cross_reference: NCI_NCI-GLOSS:CDR0000045510
database_cross_reference: NDDF:001088
database_cross_reference: NDFRT:N0000006803
database_cross_reference: NDFRT:N0000146290
database_cross_reference: PDQ:CDR0000042546
database_cross_reference: RCD:iu1..
database_cross_reference: RCD:j52..
database_cross_reference: RCD:x02MQ
database_cross_reference: RXNORM:7975
database_cross_reference: SNM:E-8806
database_cross_reference: SNMI:C-B8050
database_cross_reference: SNOMEDCT_US:329465002
database_cross_reference: SNOMEDCT_US:330024005
database_cross_reference: SNOMEDCT_US:387235007
database_cross_reference: SNOMEDCT_US:4219002
database_cross_reference: USPMG:MTHU001502
database_cross_reference: VANDF:4017940

Thiorphan
type: Class
subclass of: Amino Acids, Sulfur
MCID: MC00012753
PMOID: PMO:00017386
Subclass_of: Amino Acids, Sulfur
Synonym: (3-Mercapto-2-benzylpropionyl)glycine
Synonym: Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-
Synonym: Thiorphan [Chemical/Ingredient]
Synonym: Tiorphan
Tree Number: T6.10.1.8.10
Tree Number: T6.2.32.1.10
database_cross_reference: DRUGBANK:DB08626
database_cross_reference: MSH:D015244
database_cross_reference: NDFRT:N0000170270

Benzothiepins
type: Class
subclass of: Sulfur Compounds
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00001596
PMOID: PMO:00017387
Subclass_of: Heterocyclic Compounds, 2-Ring
Subclass_of: Sulfur Compounds
Synonym: Benzothiepins [Chemical/Ingredient]
Tree Number: T6.2.32.2
Tree Number: T6.3.1.1.6
database_cross_reference: MSH:D001582
database_cross_reference: NDFRT:N0000166938

Endosulfan
type: Class
subclass of: Benzothiepins
MCID: MC00004514
PMOID: PMO:00017388
Subclass_of: Benzothiepins
Synonym: 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide
Synonym: Endosulfan (substance)
Synonym: Endosulfan [Chemical/Ingredient]
Synonym: Endosulphan
Synonym: Thiodan
Synonym: Thiodon
Synonym: endosulfan
Synonym: endosulphan
Synonym: thiodan
Tree Number: T6.2.32.2.1
database_cross_reference: CHV:0000004475
database_cross_reference: LCH:U001590
database_cross_reference: LCH_NW:sh85043099
database_cross_reference: MSH:D004726
database_cross_reference: NDFRT:N0000166939
database_cross_reference: SNM:E-6345
database_cross_reference: SNMI:C-23146
database_cross_reference: SNOMEDCT_US:21540002

Cyclic S-Oxides
type: Class
subclass of: Sulfur Compounds
subclass of: Heterocyclic Oxides
MCID: MC00003401
PMOID: PMO:00017389
Subclass_of: Heterocyclic Oxides
Subclass_of: Sulfur Compounds
Synonym: CYCLIC OXIDES S
Synonym: Cyclic S Oxides
Synonym: Cyclic S-Oxides [Chemical/Ingredient]
Synonym: HETEROCYCLIC OXIDES S
Synonym: Heterocyclic S Oxides
Synonym: Heterocyclic S-Oxides
Synonym: Oxides, Cyclic S
Synonym: S Oxides, Cyclic
Synonym: S-Oxides, Cyclic
Synonym: S-Oxides, Heterocyclic
Tree Number: T6.2.32.3
Tree Number: T6.3.6.3
database_cross_reference: MSH:D003499
database_cross_reference: NDFRT:N0000167037

Phenothiazines
type: Class
subclass of: Sulfur Compounds
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00010028
PMOID: PMO:00017390
Subclass_of: Heterocyclic Compounds, 3-Ring
Subclass_of: Sulfur Compounds
Synonym: Phenothiazines [Chemical/Ingredient]
Synonym: phenothiazines
Synonym: phenothiazines (medication)
Tree Number: T6.2.32.5
Tree Number: T6.3.1.2.20
database_cross_reference: CHV:0000009602
database_cross_reference: CHV:0000009603
database_cross_reference: LNC:LP16248-4
database_cross_reference: LNC:MTHU042526
database_cross_reference: MEDCIN:257549
database_cross_reference: MSH:D010640
database_cross_reference: MTH:U002160
database_cross_reference: NDFRT:N0000007544

Acepromazine
type: Class
subclass of: Phenothiazines
MCID: MC00000165
PMOID: PMO:00017391
Subclass_of: Phenothiazines
Synonym: 1-[10-(3-DIMETHYLAMINO-propyl)-10H-phenothiazin-2-yl]-ethanone
Synonym: 10-(3-Dimethylaminopropyl)phenothiazine-3-ethylone
Synonym: 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone
Synonym: 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone
Synonym: ACEPROMAZINE
Synonym: Acepromazine (substance)
Synonym: Acepromazine [Chemical/Ingredient]
Synonym: Acetazine
Synonym: Acetopromazine
Synonym: Acetylpromazine
Tree Number: T6.2.32.5.1
database_cross_reference: ATC:N05AA04
database_cross_reference: CHV:0000000596
database_cross_reference: DRUGBANK:DB01614
database_cross_reference: LNC:LP16016-5
database_cross_reference: LNC:MTHU014791
database_cross_reference: MSH:D000075
database_cross_reference: MTHSPL:54EJ303F0R
database_cross_reference: NCI:C77568
database_cross_reference: NCI_FDA:54EJ303F0R
database_cross_reference: NDDF:005220
database_cross_reference: NDFRT:N0000167279
database_cross_reference: RXNORM:155
database_cross_reference: SNMI:C-62960
database_cross_reference: SNOMEDCT_US:96218000

Azure Stains
type: Class
subclass of: Phenothiazines
MCID: MC00001450
PMOID: PMO:00017392
Subclass_of: Phenothiazines
Synonym: Azure Stains [Chemical/Ingredient]
Synonym: Stains, Azure
Tree Number: T6.2.32.5.2
database_cross_reference: MSH:D001399
database_cross_reference: NDFRT:N0000167277

Chlorpromazine
type: Class
subclass of: Phenothiazines
MCID: MC00002686
PMOID: PMO:00017393
Subclass_of: Phenothiazines
Synonym: 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-
Synonym: 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine
Synonym: 3-(2-Chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
Synonym: 3-(2-chloro-10H-Phenothiazin-10-yl)-N,N-dimethyl-1-propanamine
Synonym: Apo Chlorpromazine
Synonym: CHLORPROMAZINE
Synonym: CPZ
Synonym: CPZ - Chlorpromazine
Synonym: Chlorderazin
Synonym: Chloropromazine
Tree Number: T6.2.32.5.3
database_cross_reference: AOD:0000020954
database_cross_reference: ATC:N05AA01
database_cross_reference: CCPSS:1005827
database_cross_reference: CHV:0000002842
database_cross_reference: CSP:2264-4849
database_cross_reference: DRUGBANK:DB00477
database_cross_reference: LCH:U000981
database_cross_reference: LCH_NW:sh85024591
database_cross_reference: LNC:LP16074-4
database_cross_reference: LNC:MTHU004251
database_cross_reference: MEDCIN:41364
database_cross_reference: MMSL:4428
database_cross_reference: MMSL:d00064
database_cross_reference: MSH:D002746
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:U42B7VYA4P
database_cross_reference: NCI:C367
database_cross_reference: NCI_DCP:02739
database_cross_reference: NCI_DTP:NSC0167745
database_cross_reference: NCI_FDA:U42B7VYA4P
database_cross_reference: NDDF:004587
database_cross_reference: NDFRT:N0000006947
database_cross_reference: NDFRT:N0000146214
database_cross_reference: PDQ:CDR0000039752
database_cross_reference: PSY:08990
database_cross_reference: RCD:x01BP
database_cross_reference: RXNORM:2403
database_cross_reference: SNM:E-7911
database_cross_reference: SNMI:C-62910
database_cross_reference: SNOMEDCT_US:387258005
database_cross_reference: SNOMEDCT_US:47331002
database_cross_reference: USPMG:MTHU000358
database_cross_reference: VANDF:4017861

Fluphenazine
type: Class
subclass of: Phenothiazines
MCID: MC00005211
PMOID: PMO:00017394
Subclass_of: Phenothiazines
Synonym: 1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine
Synonym: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-
Synonym: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-(9CI)
Synonym: 10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine
Synonym: 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine
Synonym: 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol
Synonym: 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine
Synonym: 4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
Synonym: 4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol
Synonym: 4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
Tree Number: T6.2.32.5.4
database_cross_reference: ATC:N05AB02
database_cross_reference: CHV:0000005133
database_cross_reference: CSP:2264-5314
database_cross_reference: DRUGBANK:DB00623
database_cross_reference: LNC:LP16152-8
database_cross_reference: LNC:MTHU004628
database_cross_reference: MMSL:d00237
database_cross_reference: MSH:D005476
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:S79426A41Z
database_cross_reference: NCI:C47536
database_cross_reference: NCI_FDA:S79426A41Z
database_cross_reference: NCI_NCI-GLOSS:CDR0000514357
database_cross_reference: NDDF:001473
database_cross_reference: NDFRT:N0000007109
database_cross_reference: NDFRT:N0000147853
database_cross_reference: PSY:19970
database_cross_reference: RCD:x004h
database_cross_reference: RXNORM:4496
database_cross_reference: SNM:E-7914
database_cross_reference: SNMI:C-62A20
database_cross_reference: SNOMEDCT_US:372730004
database_cross_reference: SNOMEDCT_US:41365009
database_cross_reference: USPMG:MTHU000626
database_cross_reference: VANDF:4019762

Mesoridazine
type: Class
subclass of: Phenothiazines
MCID: MC00008111
PMOID: PMO:00017395
Subclass_of: Phenothiazines
Synonym: 10-(2(1-Methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)phenothiazine
Synonym: 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylsulfinyl phenothiazine
Synonym: 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfinyl)-
Synonym: 2-Methanesulfinyl-10-[2-(1-methyl-piperidin-2-yl)-ethyl]-10H-phenothiazine
Synonym: Lidanar
Synonym: Lidanil
Synonym: MESORIDAZINE
Synonym: Mesoridazina
Synonym: Mesoridazine (product)
Synonym: Mesoridazine (substance)
Tree Number: T6.2.32.5.5
database_cross_reference: ATC:N05AC03
database_cross_reference: CHV:0000007991
database_cross_reference: DRUGBANK:DB00933
database_cross_reference: LNC:LP16189-0
database_cross_reference: LNC:MTHU003099
database_cross_reference: MEDCIN:41373
database_cross_reference: MMSL:d00889
database_cross_reference: MSH:D008653
database_cross_reference: NCI:C66100
database_cross_reference: NCI_FDA:5XE4NWM740
database_cross_reference: NDDF:004594
database_cross_reference: NDFRT:N0000006525
database_cross_reference: NDFRT:N0000147905
database_cross_reference: PSY:30970
database_cross_reference: RXNORM:6779
database_cross_reference: SNM:E-7932
database_cross_reference: SNMI:C-62B20
database_cross_reference: SNOMEDCT_US:372852001
database_cross_reference: SNOMEDCT_US:78684000
database_cross_reference: VANDF:4019816

Methotrimeprazine
type: Class
subclass of: Phenothiazines
MCID: MC00008194
PMOID: PMO:00017396
Subclass_of: Phenothiazines
Synonym: (-)-(2R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
Synonym: (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine
Synonym: 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (R)-
Synonym: 2-Methoxytrimeprazine
Synonym: LEVOMEPROMAZINE
Synonym: Levomeprazin
Synonym: Levomeprazine
Synonym: Levomepromazina
Synonym: Levomepromazine
Synonym: Levomepromazine product
Tree Number: T6.2.32.5.6
database_cross_reference: ATC:N05AA02
database_cross_reference: CHV:0000008045
database_cross_reference: DRUGBANK:DB01403
database_cross_reference: LNC:LP101194-1
database_cross_reference: LNC:LP16172-6
database_cross_reference: LNC:MTHU008733
database_cross_reference: LNC:MTHU035946
database_cross_reference: MEDCIN:40211
database_cross_reference: MMSL:5078
database_cross_reference: MMSL:d00814
database_cross_reference: MSH:D008728
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C66118
database_cross_reference: NCI_FDA:9G0LAW7ATQ
database_cross_reference: NDDF:001581
database_cross_reference: NDFRT:N0000007377
database_cross_reference: NDFRT:N0000147208
database_cross_reference: RCD:d48..
database_cross_reference: RXNORM:6852
database_cross_reference: SNM:E-7779
database_cross_reference: SNMI:C-62920
database_cross_reference: SNMI:C-62921
database_cross_reference: SNOMEDCT_US:363585008
database_cross_reference: SNOMEDCT_US:387509007
database_cross_reference: SNOMEDCT_US:57911003
database_cross_reference: SNOMEDCT_US:89029005
database_cross_reference: VANDF:4018915

Methylene Blue
type: Class
subclass of: Phenothiazines
MCID: MC00008220
PMOID: PMO:00017397
Subclass_of: Phenothiazines
Synonym: Azul de Metileno
Synonym: Basic Blue 9
Synonym: Blu di Metilene
Synonym: Blue Collyrium
Synonym: Blue N, Methylene
Synonym: Blue, Methylene
Synonym: Blue, Swiss
Synonym: C.I. basic blue 9
Synonym: CI Basic Blue 9
Synonym: Collyre Bleu
Tree Number: T6.2.32.5.7
database_cross_reference: ATC:V03AB17
database_cross_reference: ATC:V04CG05
database_cross_reference: CHV:0000008055
database_cross_reference: DRUGBANK:DB09241
database_cross_reference: LCH:U002944
database_cross_reference: LCH_NW:sh85084425
database_cross_reference: MEDCIN:41523
database_cross_reference: MMSL:1036
database_cross_reference: MMSL:5090
database_cross_reference: MMSL:d01128
database_cross_reference: MSH:C469427
database_cross_reference: MSH:D008751
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:8NAP7826UB
database_cross_reference: MTHSPL:T42P99266K
database_cross_reference: NCI:C644
database_cross_reference: NCI_DCP:03123
database_cross_reference: NCI_DTP:NSC0003089
database_cross_reference: NCI_DTP:NSC0617593
database_cross_reference: NCI_FDA:T42P99266K
database_cross_reference: NDDF:001094
database_cross_reference: NDDF:002616
database_cross_reference: NDDF:002877
database_cross_reference: NDFRT:N0000007449
database_cross_reference: NDFRT:N0000146895
database_cross_reference: PDQ:CDR0000041780
database_cross_reference: RCD:x02Ms
database_cross_reference: RXNORM:6878
database_cross_reference: SNM:E-8804
database_cross_reference: SNMI:C-22947
database_cross_reference: SNOMEDCT_US:354064008
database_cross_reference: SNOMEDCT_US:410906004
database_cross_reference: SNOMEDCT_US:6725000
database_cross_reference: VANDF:4018579

Nonachlazine
type: Class
subclass of: Phenothiazines
MCID: MC00008986
PMOID: PMO:00017398
Subclass_of: Phenothiazines
Synonym: 10H-Phenothiazine, 2-chloro-10-(3-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-1-oxopropyl)-, dihydrochloride
Synonym: AZACLORZINE
Synonym: Azaclorzine
Synonym: Nonachlazin
Synonym: Nonachlazine [Chemical/Ingredient]
Synonym: Nonakhlazin
Tree Number: T6.2.32.5.8
database_cross_reference: MSH:D009628
database_cross_reference: NCI:C74421
database_cross_reference: NCI_FDA:7N4BHX8N3L
database_cross_reference: NDFRT:N0000167281

Perazine
type: Class
subclass of: Phenothiazines
MCID: MC00009879
PMOID: PMO:00017399
Subclass_of: Phenothiazines
Synonym: 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-
Synonym: PERAZINE
Synonym: Perazine (substance)
Synonym: Perazine [Chemical/Ingredient]
Synonym: Pernazine
Synonym: perazine
Tree Number: T6.2.32.5.9
database_cross_reference: ATC:N05AB10
database_cross_reference: CHV:0000009467
database_cross_reference: DRUGBANK:DB12710
database_cross_reference: MSH:D010464
database_cross_reference: NCI:C81093
database_cross_reference: NCI_FDA:8915147A2B
database_cross_reference: NDDF:006779
database_cross_reference: NDFRT:N0000167278
database_cross_reference: RXNORM:8042
database_cross_reference: SNM:E-7957
database_cross_reference: SNMI:C-62655
database_cross_reference: SNOMEDCT_US:25002001

Perphenazine
type: Class
subclass of: Phenothiazines
MCID: MC00009952
PMOID: PMO:00017400
Subclass_of: Phenothiazines
Synonym: 1-Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-
Synonym: 2-(4-[3-(2-chloro-10H-Phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol
Synonym: 2-chloro-10-(3-(4-(2-Hydroxyethyl)piperazin-1-yl)propyl)phenothiazine
Synonym: 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
Synonym: 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol
Synonym: 4-[3-(2-chloro-10H-Phenothiazin-10-yl)propyl]-1-piperazineethanol
Synonym: Apo Peram Tab 2-25
Synonym: Apo Peram Tab 3-15
Synonym: Chlorpiprazine
Synonym: Decentan
Tree Number: T6.2.32.5.10
database_cross_reference: AOD:0000020955
database_cross_reference: ATC:N05AB03
database_cross_reference: CHV:0000009538
database_cross_reference: DRUGBANK:DB00850
database_cross_reference: LNC:LP16242-7
database_cross_reference: LNC:MTHU012951
database_cross_reference: MEDCIN:48435
database_cross_reference: MMSL:2271
database_cross_reference: MMSL:5261
database_cross_reference: MMSL:d00855
database_cross_reference: MSH:D010546
database_cross_reference: MTHSPL:FTA7XXY4EZ
database_cross_reference: NCI:C29355
database_cross_reference: NCI_DCP:06627
database_cross_reference: NCI_FDA:FTA7XXY4EZ
database_cross_reference: NDDF:001477
database_cross_reference: NDFRT:N0000006769
database_cross_reference: NDFRT:N0000146289
database_cross_reference: PSY:37600
database_cross_reference: RCD:d4b..
database_cross_reference: RCD:o58..
database_cross_reference: RCD:x02LS
database_cross_reference: RCDAE:o58..
database_cross_reference: RXNORM:8076
database_cross_reference: SNM:E-7934
database_cross_reference: SNMI:C-62A30
database_cross_reference: SNOMEDCT_US:321477009
database_cross_reference: SNOMEDCT_US:334019003
database_cross_reference: SNOMEDCT_US:387229007
database_cross_reference: SNOMEDCT_US:41147003
database_cross_reference: USPMG:MTHU000370
database_cross_reference: VANDF:4017939

Prochlorperazine
type: Class
subclass of: Phenothiazines
MCID: MC00010643
PMOID: PMO:00017401
Subclass_of: Phenothiazines
Synonym: 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-
Synonym: 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine
Synonym: 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine
Synonym: 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine
Synonym: 3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine
Synonym: Chlormeprazine
Synonym: Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine
Synonym: Chloropernazine
Synonym: N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine
Synonym: Nu-prochlor Tab 10mg
Tree Number: T6.2.32.5.11
database_cross_reference: AOD:0000020956
database_cross_reference: ATC:N05AB04
database_cross_reference: CCPSS:0032199
database_cross_reference: CHV:0000010141
database_cross_reference: CSP:2264-5872
database_cross_reference: DRUGBANK:DB00433
database_cross_reference: LNC:LP102316-9
database_cross_reference: LNC:MTHU036745
database_cross_reference: MEDCIN:41130
database_cross_reference: MMSL:2073
database_cross_reference: MMSL:5361
database_cross_reference: MMSL:d00355
database_cross_reference: MSH:D011346
database_cross_reference: MTHSPL:YHP6YLT61T
database_cross_reference: NCI:C774
database_cross_reference: NCI_FDA:YHP6YLT61T
database_cross_reference: NCI_NCI-GLOSS:CDR0000045232
database_cross_reference: NDDF:001478
database_cross_reference: NDFRT:N0000005824
database_cross_reference: NDFRT:N0000146346
database_cross_reference: PDQ:CDR0000039564
database_cross_reference: PSY:40640
database_cross_reference: RCD:d4d..
database_cross_reference: RCD:dhe..
database_cross_reference: RCD:x02LV
database_cross_reference: RXNORM:8704
database_cross_reference: SNM:E-8245
database_cross_reference: SNMI:C-62A40
database_cross_reference: SNOMEDCT_US:321493000
database_cross_reference: SNOMEDCT_US:322128008
database_cross_reference: SNOMEDCT_US:372853006
database_cross_reference: SNOMEDCT_US:79129001
database_cross_reference: USPMG:MTHU000371
database_cross_reference: VANDF:4018001

Promazine
type: Class
subclass of: Phenothiazines
MCID: MC00010687
PMOID: PMO:00017402
Subclass_of: Phenothiazines
Synonym: 10-(3-(Dimethylamino)propyl)phenothiazine
Synonym: 10H-Phenothiazine-10-propanamine, N,N-dimethyl-
Synonym: Combelen
Synonym: N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine
Synonym: N-(3-Dimethylaminopropyl)phenothiazine
Synonym: N-Dimethylamino-1-methylethyl thiodiphenylamine
Synonym: PROMAZINE
Synonym: Prazine
Synonym: Promazin
Synonym: Promazina
Tree Number: T6.2.32.5.12
database_cross_reference: AOD:0000020957
database_cross_reference: ATC:N05AA03
database_cross_reference: CHV:0000010178
database_cross_reference: CSP:2264-5965
database_cross_reference: DRUGBANK:DB00420
database_cross_reference: LNC:LP16264-1
database_cross_reference: LNC:MTHU003381
database_cross_reference: MMSL:7219
database_cross_reference: MMSL:d00356
database_cross_reference: MSH:D011395
database_cross_reference: NCI:C61908
database_cross_reference: NCI_FDA:O9M39HTM5W
database_cross_reference: NDDF:004588
database_cross_reference: NDFRT:N0000006005
database_cross_reference: NDFRT:N0000147994
database_cross_reference: PSY:41040
database_cross_reference: RCD:x01BX
database_cross_reference: RXNORM:8742
database_cross_reference: SNM:E-7938
database_cross_reference: SNMI:C-62930
database_cross_reference: SNOMEDCT_US:372741002
database_cross_reference: SNOMEDCT_US:44658005
database_cross_reference: VANDF:4019909

Thiethylperazine
type: Class
subclass of: Phenothiazines
subclass of: Piperazines
MCID: MC00012720
PMOID: PMO:00017403
Subclass_of: Phenothiazines
Subclass_of: Piperazines
Synonym: 10H-Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-
Synonym: 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
Synonym: Novartis Brand of Thiethlperazine
Synonym: THIETHYLPERAZINE
Synonym: Thiethlperazine Novartis Brand
Synonym: Thiethylperazin
Synonym: Thiethylperazine (product)
Synonym: Thiethylperazine (substance)
Synonym: Thiethylperazine [Chemical/Ingredient]
Synonym: Thiethylperazinum
Tree Number: T6.2.32.5.14
Tree Number: T6.3.5.15.26
database_cross_reference: ATC:R06AD03
database_cross_reference: DRUGBANK:DB00372
database_cross_reference: LNC:LP101134-7
database_cross_reference: LNC:MTHU036184
database_cross_reference: MEDCIN:41131
database_cross_reference: MMSL:5567
database_cross_reference: MMSL:d00857
database_cross_reference: MSH:D013847
database_cross_reference: NCI:C62081
database_cross_reference: NCI_FDA:8ETK1WAF6R
database_cross_reference: NCI_NCI-GLOSS:CDR0000467870
database_cross_reference: NDDF:004595
database_cross_reference: NDFRT:N0000007176
database_cross_reference: NDFRT:N0000148028
database_cross_reference: RCD:dhh..
database_cross_reference: RXNORM:10471
database_cross_reference: SNM:E-8247
database_cross_reference: SNMI:C-62A50
database_cross_reference: SNOMEDCT_US:36218003
database_cross_reference: SNOMEDCT_US:372719002
database_cross_reference: VANDF:4019943

Thioridazine
type: Class
subclass of: Phenothiazines
MCID: MC00012752
PMOID: PMO:00017404
Subclass_of: Phenothiazines
Synonym: 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine
Synonym: 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-
Synonym: 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine
Synonym: 3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine
Synonym: Mellaril Tab 100mg
Synonym: Mellaril Tab 10mg
Synonym: Mellaril Tab 200mg
Synonym: Mellaril Tab 25mg
Synonym: Mellaril Tab 50mg
Synonym: Novo-ridazine (thioridazine Oral Suspension) - 2 mg/ml
Tree Number: T6.2.32.5.15
database_cross_reference: AOD:0000020959
database_cross_reference: ATC:N05AC02
database_cross_reference: CHV:0000012192
database_cross_reference: CSP:2264-6244
database_cross_reference: DRUGBANK:DB00679
database_cross_reference: LCH:U004656
database_cross_reference: LCH_NW:sh85134889
database_cross_reference: LNC:LP16290-6
database_cross_reference: LNC:MTHU003228
database_cross_reference: MEDCIN:41377
database_cross_reference: MMSL:5571
database_cross_reference: MMSL:d00389
database_cross_reference: MSH:D013881
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:N3D6TG58NI
database_cross_reference: NCI:C61971
database_cross_reference: NCI_FDA:N3D6TG58NI
database_cross_reference: NDDF:004591
database_cross_reference: NDFRT:N0000007283
database_cross_reference: NDFRT:N0000148031
database_cross_reference: PSY:52900
database_cross_reference: RCD:x01BY
database_cross_reference: RXNORM:10502
database_cross_reference: SNM:E-7945
database_cross_reference: SNMI:C-62B10
database_cross_reference: SNOMEDCT_US:33588000
database_cross_reference: SNOMEDCT_US:372706001
database_cross_reference: USPMG:MTHU000632
database_cross_reference: VANDF:4019946

Tolonium Chloride
type: Class
subclass of: Phenothiazines
MCID: MC00012900
PMOID: PMO:00017405
Subclass_of: Phenothiazines
Synonym: 3-Amino-7-Dimethylamino-2-Methylphenazathionium Chloride
Synonym: Blue O, Toluidine
Synonym: Blue, Toluidine
Synonym: Chloride, Tolonium
Synonym: Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
Synonym: TOLONIUM CHLORIDE
Synonym: Tolonium Chloride [Chemical/Ingredient]
Synonym: Tolonium chloride
Synonym: Tolonium chloride (product)
Synonym: Tolonium chloride (substance)
Tree Number: T6.2.32.5.16
database_cross_reference: CHV:0000012343
database_cross_reference: LCH_NW:sh85135909
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D014048
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87726
database_cross_reference: NCI_FDA:15XUH0X66N
database_cross_reference: NDDF:002095
database_cross_reference: NDFRT:N0000167280
database_cross_reference: RCD:X7995
database_cross_reference: RXNORM:10638
database_cross_reference: SNM:E-8467
database_cross_reference: SNMI:C-22951
database_cross_reference: SNMI:C-A7045
database_cross_reference: SNOMEDCT_US:18306009
database_cross_reference: SNOMEDCT_US:29522004
database_cross_reference: SNOMEDCT_US:417083005

Trifluoperazine
type: Class
subclass of: Phenothiazines
MCID: MC00013079
PMOID: PMO:00017406
Subclass_of: Phenothiazines
Synonym: 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine
Synonym: 10-[3-(4-METHYL-piperazin-1-yl)-propyl]-2-trifluoromethyl-10H-phenothiazine
Synonym: 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
Synonym: 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-
Synonym: Eskazinyl
Synonym: Modalina
Synonym: Novo-flurazine Tab 1mg
Synonym: Novo-flurazine Tab 20mg
Synonym: Novo-trifluzine - Tab 10mg
Synonym: Novo-trifluzine - Tab 2mg
Tree Number: T6.2.32.5.17
database_cross_reference: AOD:0000020960
database_cross_reference: ATC:N05AB06
database_cross_reference: CCPSS:0019501
database_cross_reference: CHV:0000012555
database_cross_reference: CSP:2264-4570
database_cross_reference: CSP:2484-5600
database_cross_reference: CSP:2484-5660
database_cross_reference: DRUGBANK:DB00831
database_cross_reference: LNC:LP16299-7
database_cross_reference: LNC:MTHU003230
database_cross_reference: MMSL:d00890
database_cross_reference: MSH:D014268
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:214IZI85K3
database_cross_reference: NCI:C62084
database_cross_reference: NCI_DCP:05084
database_cross_reference: NCI_FDA:214IZI85K3
database_cross_reference: NDDF:004590
database_cross_reference: NDFRT:N0000006112
database_cross_reference: NDFRT:N0000148042
database_cross_reference: PSY:54230
database_cross_reference: RCD:d4h..
database_cross_reference: RCD:dhi..
database_cross_reference: RCD:x02LW
database_cross_reference: RXNORM:10800
database_cross_reference: SNM:E-7948
database_cross_reference: SNMI:C-62A60
database_cross_reference: SNOMEDCT_US:321537004
database_cross_reference: SNOMEDCT_US:322164009
database_cross_reference: SNOMEDCT_US:373524005
database_cross_reference: SNOMEDCT_US:71699007
database_cross_reference: USPMG:MTHU000634
database_cross_reference: VANDF:4019957

Triflupromazine
type: Class
subclass of: Phenothiazines
MCID: MC00013084
PMOID: PMO:00017407
Subclass_of: Phenothiazines
Synonym: 10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine
Synonym: 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-
Synonym: 2-(Trifluoromethyl)promazine
Synonym: 2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine
Synonym: Fluopromazine
Synonym: TRIFLUPROMAZINE
Synonym: Trifluopromazine
Synonym: Triflupromazin
Synonym: Triflupromazina
Synonym: Triflupromazine (product)
Tree Number: T6.2.32.5.18
database_cross_reference: ATC:N05AA05
database_cross_reference: CHV:0000012557
database_cross_reference: DRUGBANK:DB00508
database_cross_reference: LNC:LP18060-1
database_cross_reference: LNC:MTHU003231
database_cross_reference: MEDCIN:41380
database_cross_reference: MMSL:d03152
database_cross_reference: MSH:D014273
database_cross_reference: NCI:C66635
database_cross_reference: NCI_FDA:RO16TQF95Y
database_cross_reference: NDDF:004589
database_cross_reference: NDFRT:N0000006126
database_cross_reference: NDFRT:N0000148043
database_cross_reference: PSY:54240
database_cross_reference: RXNORM:10805
database_cross_reference: SNM:E-7947
database_cross_reference: SNMI:C-62940
database_cross_reference: SNOMEDCT_US:30329006
database_cross_reference: SNOMEDCT_US:398816002
database_cross_reference: VANDF:4019958

Trimeprazine
type: Class
subclass of: Phenothiazines
MCID: MC00013109
PMOID: PMO:00017408
Subclass_of: Phenothiazines
Synonym: 10-(2-Methyl-3-dimethylaminopropyl)-phenothiazine
Synonym: 10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-
Synonym: Alimemazine
Synonym: Alimezine
Synonym: Isobutrazine
Synonym: Methylpromazine
Synonym: Panectyl 2.5 Liq 2.5mg/5ml
Synonym: Panectyl Tab 2.5mg
Synonym: Panectyl Tab 5mg
Synonym: TRIMEPRAZINE
Tree Number: T6.2.32.5.19
database_cross_reference: ATC:R06AD01
database_cross_reference: CHV:0000012569
database_cross_reference: DRUGBANK:DB01246
database_cross_reference: LNC:LP18061-9
database_cross_reference: LNC:MTHU003232
database_cross_reference: MMSL:d00788
database_cross_reference: MSH:D014291
database_cross_reference: MTHSPL:76H78MJJ52
database_cross_reference: NCI:C72677
database_cross_reference: NCI_FDA:76H78MJJ52
database_cross_reference: NDDF:001535
database_cross_reference: NDFRT:N0000007601
database_cross_reference: NDFRT:N0000148045
database_cross_reference: RCD:x01EB
database_cross_reference: RXNORM:10825
database_cross_reference: SNM:E-884X
database_cross_reference: SNMI:C-62950
database_cross_reference: SNOMEDCT_US:387471006
database_cross_reference: SNOMEDCT_US:8109005
database_cross_reference: VANDF:4019960

Moricizine
type: Class
subclass of: Phenothiazines
MCID: MC00041185
PMOID: PMO:00017409
Subclass_of: Phenothiazines
Synonym: Carbamic acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, ethyl ester
Synonym: Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate
Synonym: Ethyl 10-(beta-N-morpholinylpropionyl)phenothiazine-2-carbamate
Synonym: Etmozins
Synonym: MORICIZINE
Synonym: Moracizin
Synonym: Moracizina
Synonym: Moracizine
Synonym: Moracizine (product)
Synonym: Moracizine (substance)
Tree Number: T6.2.32.5.20
database_cross_reference: ATC:C01BG01
database_cross_reference: CHV:0000015250
database_cross_reference: DRUGBANK:DB00680
database_cross_reference: LNC:LP17996-7
database_cross_reference: LNC:MTHU024863
database_cross_reference: MEDCIN:42327
database_cross_reference: MMSL:d00307
database_cross_reference: MSH:D016293
database_cross_reference: NCI:C66196
database_cross_reference: NCI_FDA:2GT1D0TMX1
database_cross_reference: NDDF:004488
database_cross_reference: NDFRT:N0000006334
database_cross_reference: NDFRT:N0000147932
database_cross_reference: RCD:x01QL
database_cross_reference: RXNORM:40169
database_cross_reference: SNOMEDCT_US:108488000
database_cross_reference: SNOMEDCT_US:350598002
database_cross_reference: SNOMEDCT_US:373726009
database_cross_reference: VANDF:4019845

Sulfhydryl Compounds
type: Class
subclass of: Sulfur Compounds
MCID: MC00012387
PMOID: PMO:00017410
Subclass_of: Sulfur Compounds
Synonym: Compounds, Mercapto
Synonym: Compounds, Sulfhydryl
Synonym: MERCAPTO CPDS
Synonym: Mercaptans
Synonym: Mercapto Compounds
Synonym: SULFHYDRYL CPDS
Synonym: Sulfhydryl Compounds [Chemical/Ingredient]
Synonym: Sulfhydryls
Synonym: Sulfhydryls (substance)
Synonym: Sulphydryls
Tree Number: T6.2.32.6
database_cross_reference: AOD:0000020599
database_cross_reference: CHV:0000011861
database_cross_reference: CSP:2908-9563
database_cross_reference: LCH:U006201
database_cross_reference: LCH_NW:sh85134883
database_cross_reference: LNC:LP17856-3
database_cross_reference: LNC:MTHU024714
database_cross_reference: MSH:D013438
database_cross_reference: NDFRT:N0000008041
database_cross_reference: SNOMEDCT_US:115582009

Dimercaprol
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00003952
PMOID: PMO:00017411
Subclass_of: Sulfhydryl Compounds
Synonym: 1,2-Dimercapto-3-propanol
Synonym: 1,2-Dithioglycerol
Synonym: 1-Propanol, 2,3-dimercapto-
Synonym: 2,3 Dimercaptopropanol
Synonym: 2,3 Dithiopropan 1 o1
Synonym: 2,3-Dimercapro
Synonym: 2,3-Dimercapto-1-propanol
Synonym: 2,3-Dimercaptol-1-propanol
Synonym: 2,3-Dimercaptopropanol
Synonym: 2,3-Dithiopropan-1-o1
Tree Number: T6.2.32.6.2
database_cross_reference: ATC:V03AB09
database_cross_reference: CHV:0000003961
database_cross_reference: DRUGBANK:DB06782
database_cross_reference: LNC:LP36498-1
database_cross_reference: LNC:MTHU019664
database_cross_reference: MEDCIN:40653
database_cross_reference: MMSL:4606
database_cross_reference: MMSL:d01401
database_cross_reference: MSH:D004112
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:0CPP32S55X
database_cross_reference: NCI:C47494
database_cross_reference: NCI_DCP:30435
database_cross_reference: NCI_FDA:0CPP32S55X
database_cross_reference: NDDF:001087
database_cross_reference: NDFRT:N0000006685
database_cross_reference: NDFRT:N0000146440
database_cross_reference: RCD:at1..
database_cross_reference: RXNORM:3445
database_cross_reference: SNM:E-8812
database_cross_reference: SNMI:C-B8020
database_cross_reference: SNOMEDCT_US:13664004
database_cross_reference: SNOMEDCT_US:387077001
database_cross_reference: VANDF:4018102

Ergothioneine
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00004655
PMOID: PMO:00017413
Subclass_of: Sulfhydryl Compounds
Synonym: 1H-Imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (S)-
Synonym: 2 Thiol L histidine betaine
Synonym: 2-Thiol-L-histidine-betaine
Synonym: ERGOTHIONEINE
Synonym: Ergothioneine [Chemical/Ingredient]
Synonym: Thioneine
Synonym: ergothioneine
Tree Number: T6.2.32.6.4
database_cross_reference: MSH:D004880
database_cross_reference: MTHSPL:BDZ3DQM98W
database_cross_reference: NDDF:011897
database_cross_reference: NDFRT:N0000170243
database_cross_reference: RXNORM:1314350

Methimazole
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00008178
PMOID: PMO:00017414
Subclass_of: Sulfhydryl Compounds
Synonym: 1 Methyl 2 mercaptoimidazole
Synonym: 1-METHYL-1,3-dihydro-2H-imidazole-2-thione
Synonym: 1-Methyl-2-mercaptoimidazole
Synonym: 1-Methylimidazole-2(3H)-thione
Synonym: 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-
Synonym: Apo-methimazole
Synonym: Dom-methimazole
Synonym: METHIMAZOLE
Synonym: Mercasolyl
Synonym: Mercazolyl
Tree Number: T6.2.32.6.7
database_cross_reference: ATC:H03BB02
database_cross_reference: CHV:0000008037
database_cross_reference: CSP:1549-3456
database_cross_reference: DRUGBANK:DB00763
database_cross_reference: LNC:LP18583-2
database_cross_reference: LNC:MTHU004698
database_cross_reference: MEDCIN:40482
database_cross_reference: MMSL:31962
database_cross_reference: MMSL:5073
database_cross_reference: MMSL:d00290
database_cross_reference: MSH:D008713
database_cross_reference: MTHSPL:554Z48XN5E
database_cross_reference: NCI:C641
database_cross_reference: NCI_DTP:NSC0038608
database_cross_reference: NCI_FDA:554Z48XN5E
database_cross_reference: NDDF:002139
database_cross_reference: NDFRT:N0000007339
database_cross_reference: NDFRT:N0000145822
database_cross_reference: PDQ:CDR0000039287
database_cross_reference: RXNORM:6835
database_cross_reference: SNM:E-8626
database_cross_reference: SNMI:C-A1860
database_cross_reference: SNOMEDCT_US:37656002
database_cross_reference: SNOMEDCT_US:404864000
database_cross_reference: USPMG:MTHU001438
database_cross_reference: VANDF:4017434

Pantetheine
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00009682
PMOID: PMO:00017415
Subclass_of: Sulfhydryl Compounds
Synonym: Butanamide, 2,4-dihydroxy-N-(3-((2-mercaptoethyl)amino)-3-oxopropyl)-3,3-dimethyl-, (R)-
Synonym: Pantetheine [Chemical/Ingredient]
Tree Number: T6.2.32.6.8
database_cross_reference: MSH:D010204
database_cross_reference: NDFRT:N0000166486

Mercaptopurine
type: Class
subclass of: Sulfhydryl Compounds
MCID: MC00000100
PMOID: PMO:00017416
Subclass_of: Sulfhydryl Compounds
Synonym: 1,7-Dihydro-6H-purine-6-thione
Synonym: 3H-Purine-6-thiol
Synonym: 6 MP
Synonym: 6 Mercaptopurine
Synonym: 6 Thiohypoxanthine
Synonym: 6 Thiopurine
Synonym: 6 mercaptopurine
Synonym: 6 thiopurine
Synonym: 6- mercaptopurine
Synonym: 6-MP
Tree Number: T6.2.32.6.14
database_cross_reference: ATC:L01BB02
database_cross_reference: CHV:0000000520
database_cross_reference: CSP:2910-8664
database_cross_reference: DRUGBANK:DB01033
database_cross_reference: LNC:LP15173-5
database_cross_reference: LNC:MTHU002562
database_cross_reference: MEDCIN:40514
database_cross_reference: MMSL:48948
database_cross_reference: MMSL:5052
database_cross_reference: MMSL:d00289
database_cross_reference: MSH:D015122
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:E7WED276I5
database_cross_reference: NCI:C195
database_cross_reference: NCI_DCP:06674
database_cross_reference: NCI_DTP:NSC0000755
database_cross_reference: NCI_FDA:E7WED276I5
database_cross_reference: NCI_NCI-GLOSS:CDR0000046639
database_cross_reference: NDDF:002647
database_cross_reference: NDFRT:N0000006010
database_cross_reference: NDFRT:N0000147079
database_cross_reference: PDQ:CDR0000043436
database_cross_reference: RCD:h33..
database_cross_reference: RXNORM:103
database_cross_reference: SNM:E-8333
database_cross_reference: SNMI:C-78160
database_cross_reference: SNOMEDCT_US:1039008
database_cross_reference: SNOMEDCT_US:386835005
database_cross_reference: USPMG:MTHU000490
database_cross_reference: USPMG:MTHU003320
database_cross_reference: VANDF:4018776

Sulfones
type: Class
subclass of: Sulfur Compounds
MCID: MC00012404
PMOID: PMO:00017417
Subclass_of: Sulfur Compounds
Synonym: 55D SULFONES
Synonym: SULFONES
Synonym: Sulfone
Synonym: Sulfone (substance)
Synonym: Sulfone - chemical
Synonym: Sulfone - chemical (substance)
Synonym: Sulfone Anti-Infective Agent
Synonym: Sulfone, NOS
Synonym: Sulfones [Chemical/Ingredient]
Synonym: Sulphone
Tree Number: T6.2.32.8
database_cross_reference: AOD:0000019643
database_cross_reference: CHV:0000011869
database_cross_reference: CSP:2840-5918
database_cross_reference: LCH_NW:sh85130357
database_cross_reference: MSH:D013450
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C849
database_cross_reference: NDFRT:N0000008053
database_cross_reference: SNMI:C-55D00
database_cross_reference: SNOMEDCT_US:27571004
database_cross_reference: SNOMEDCT_US:363549008

Dapsone
type: Class
subclass of: Sulfones
MCID: MC00003543
PMOID: PMO:00017418
Subclass_of: Sulfones
Synonym: 1,1'-Sulfonylbis(4-aminobenzene)
Synonym: 1,1'-Sulfonylbis[4-aminobenzene]
Synonym: 4,4' Diaminophenyl Sulfone
Synonym: 4,4'-Dapsone
Synonym: 4,4'-Diaminodiphenyl sulfone
Synonym: 4,4'-Diaminodiphenyl sulphone
Synonym: 4,4'-Diaminodiphenylsulfone
Synonym: 4,4'-Diaminophenyl Sulfone
Synonym: 4,4'-Sulfonylbis[benzenamine]
Synonym: 4,4'-Sulfonylbisaniline
Tree Number: T6.2.32.8.2
database_cross_reference: ATC:D10AX05
database_cross_reference: ATC:J04BA02
database_cross_reference: CCPSS:0008569
database_cross_reference: CHV:0000003609
database_cross_reference: CSP:2840-6854
database_cross_reference: DRUGBANK:DB00250
database_cross_reference: LCH_NW:sh95004946
database_cross_reference: LNC:LP17991-8
database_cross_reference: LNC:LP32038-9
database_cross_reference: LNC:MTHU024811
database_cross_reference: MEDCIN:40826
database_cross_reference: MMSL:4536
database_cross_reference: MMSL:682
database_cross_reference: MMSL:d00098
database_cross_reference: MSH:D003622
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:8W5C518302
database_cross_reference: NCI:C415
database_cross_reference: NCI_DCP:01594
database_cross_reference: NCI_DTP:NSC0006091
database_cross_reference: NCI_FDA:8W5C518302
database_cross_reference: NCI_NCI-GLOSS:CDR0000661174
database_cross_reference: NDDF:003003
database_cross_reference: NDFRT:N0000006908
database_cross_reference: NDFRT:N0000147467
database_cross_reference: PDQ:CDR0000040323
database_cross_reference: PDQ:CDR0000494629
database_cross_reference: RCD:ee1..
database_cross_reference: RXNORM:3108
database_cross_reference: SNM:E-7341
database_cross_reference: SNMI:C-55292
database_cross_reference: SNOMEDCT_US:17308007
database_cross_reference: SNOMEDCT_US:387096002
database_cross_reference: USPMG:MTHU000461
database_cross_reference: VANDF:4019264

Phenylmethylsulfonyl Fluoride
type: Class
subclass of: Sulfones
MCID: MC00010055
PMOID: PMO:00017420
Subclass_of: Sulfones
Synonym: Benzenemethanesulfonyl Fluoride
Synonym: Benzenemethanesulfonyl fluoride
Synonym: Fluoride, Benzenemethanesulfonyl
Synonym: Fluoride, Phenylmethanesulfonyl
Synonym: Fluoride, Phenylmethylsulfonyl
Synonym: Phenylmethanesulfonyl Fluoride
Synonym: Phenylmethylsulfonyl Fluoride [Chemical/Ingredient]
Tree Number: T6.2.32.8.3
database_cross_reference: MSH:D010664
database_cross_reference: NDFRT:N0000166473

Simeprevir
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00728036
PMOID: PMO:00017421
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Galexos
Synonym: HSDB 8227
Synonym: N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide
Synonym: SIMEPREVIR
Synonym: Simeprevir (product)
Synonym: Simeprevir (substance)
Synonym: Simeprevir [Chemical/Ingredient]
Synonym: antiviral simeprevir
Synonym: simeprevir
Synonym: simeprevir (medication)
Tree Number: T6.3.1.2.1
database_cross_reference: ATC:J05AE14
database_cross_reference: DRUGBANK:DB06290
database_cross_reference: LNC:LP220644-1
database_cross_reference: LNC:MTHU054610
database_cross_reference: MEDCIN:343276
database_cross_reference: MMSL:d08182
database_cross_reference: MSH:D000069616
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9WS5RD66HZ
database_cross_reference: NCI:C129015
database_cross_reference: NCI_FDA:9WS5RD66HZ
database_cross_reference: NDDF:015309
database_cross_reference: NDFRT:N0000189533
database_cross_reference: NDFRT:N0000191970
database_cross_reference: RXNORM:1482790
database_cross_reference: SNOMEDCT_US:708823009
database_cross_reference: SNOMEDCT_US:714167009
database_cross_reference: USPMG:MTHU002665
database_cross_reference: VANDF:4032900

Benzothiadiazines
type: Class
subclass of: Thiazides
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00001595
PMOID: PMO:00017422
Subclass_of: Heterocyclic Compounds, 2-Ring
Subclass_of: Thiazides
Synonym: Benzothiadiazines [Chemical/Ingredient]
Tree Number: T6.2.32.28.1
Tree Number: T6.3.1.1.5
database_cross_reference: MSH:D001581
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007554

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
type: Class
subclass of: Piperazines
MCID: MC00014316
PMOID: PMO:00017432
Subclass_of: Piperazines
Synonym: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine [Chemical/Ingredient]
Synonym: 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine
Synonym: 1-(5-Isoquinolinylsulfonyl)-2-Methylpiperazine
Synonym: 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine
Synonym: 5-(2-methylpiperazine-1-sulfonyl)isoquinoline
Synonym: H 7
Synonym: H A 07
Synonym: H-7
Synonym: IQSMP
Synonym: ISOQUINOLINESULFONYL METHYLPIPERAZINE 01 05 02
Tree Number: T6.3.5.15.32
database_cross_reference: DRUGBANK:DB07996
database_cross_reference: MSH:D019307
database_cross_reference: NDFRT:N0000167120

Sulfonylurea Compounds
type: Class
subclass of: Sulfones
subclass of: Urea
MCID: MC00012407
PMOID: PMO:00017433
Subclass_of: Sulfones
Subclass_of: Urea
Synonym: A24 SULFONYLUREAS
Synonym: Compounds, Sulfonylurea
Synonym: SULFONYLUREA CPDS
Synonym: SULFONYLUREAS
Synonym: Sulfonylurea
Synonym: Sulfonylurea (product)
Synonym: Sulfonylurea (substance)
Synonym: Sulfonylurea Compounds [Chemical/Ingredient]
Synonym: Sulfonylurea [dup] (substance)
Synonym: Sulfonylurea and its derivatives
Tree Number: T6.2.32.8.5
Tree Number: T6.2.34.9
database_cross_reference: AOD:0000019645
database_cross_reference: CHV:0000011871
database_cross_reference: CSP:2841-3410
database_cross_reference: LCH_NW:sh2007001704
database_cross_reference: LNC:LP18787-9
database_cross_reference: LNC:MTHU005387
database_cross_reference: MEDCIN:194714
database_cross_reference: MSH:D013453
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008054
database_cross_reference: PDQ:CDR0000039289
database_cross_reference: RCD:X80NJ
database_cross_reference: RCD:XM0lF
database_cross_reference: RCD:f3...
database_cross_reference: RCDAE:X80NJ
database_cross_reference: RCDAE:XM0lF
database_cross_reference: RCDAE:f3...
database_cross_reference: SNMI:C-A2400
database_cross_reference: SNOMEDCT_US:259552008
database_cross_reference: SNOMEDCT_US:273950002
database_cross_reference: SNOMEDCT_US:34012005
database_cross_reference: SNOMEDCT_US:372711004

Acetohexamide
type: Class
subclass of: Sulfonylurea Compounds
MCID: MC00000184
PMOID: PMO:00017434
Subclass_of: Sulfonylurea Compounds
Synonym: 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea
Synonym: 1-(p-Acetylbenzenesulfonyl)-3-Cyclohexylurea
Synonym: 1-[(4-acetylbenzene)sulfonyl]-3-cyclohexylurea 4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide
Synonym: 3-Cyclohexyl-1-(p-acetylphenylsulfonyl)urea
Synonym: ACETOHEXAMIDE
Synonym: AcetoHEXAMIDE
Synonym: Acetohexamid
Synonym: Acetohexamida
Synonym: Acetohexamide (product)
Tree Number: T6.2.34.9.1
database_cross_reference: ATC:A10BB31
database_cross_reference: DRUGBANK:DB00414
database_cross_reference: LNC:LP17249-1
database_cross_reference: LNC:MTHU012977
database_cross_reference: MEDCIN:40371
database_cross_reference: MMSL:4123
database_cross_reference: MMSL:873
database_cross_reference: MMSL:d00162
database_cross_reference: MSH:D000092
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C47380
database_cross_reference: NCI_FDA:QGC8W08I6I
database_cross_reference: NDDF:000907
database_cross_reference: NDFRT:N0000007387
database_cross_reference: NDFRT:N0000145888
database_cross_reference: RCD:f31..
database_cross_reference: RXNORM:173
database_cross_reference: SNM:E-8594
database_cross_reference: SNMI:C-A2410
database_cross_reference: SNOMEDCT_US:387210001
database_cross_reference: SNOMEDCT_US:39064002
database_cross_reference: SNOMEDCT_US:391707002
database_cross_reference: SNOMEDCT_US:391708007
database_cross_reference: VANDF:4017503

Carbutamide
type: Class
subclass of: Sulfonylurea Compounds
MCID: MC00002270
PMOID: PMO:00017435
Subclass_of: Sulfonylurea Compounds
Synonym: Aminophenurobutane
Synonym: Benzenesulfonamide, 4-amino-N-((butylamino)carbonyl)-
Synonym: CARBUTAMIDE
Synonym: Carbutamide [Chemical/Ingredient]
Synonym: Diabetal
Synonym: Glybutamide
Synonym: Sulfaninylbutylurea
Synonym: carbutamide
Tree Number: T6.2.34.9.2
database_cross_reference: ATC:A10BB06
database_cross_reference: MSH:D002271
database_cross_reference: NCI:C83597
database_cross_reference: NCI_FDA:E3K8P4869P
database_cross_reference: NDDF:005300
database_cross_reference: NDFRT:N0000166471
database_cross_reference: RXNORM:2068

Chlorpropamide
type: Class
subclass of: Sulfonylurea Compounds
MCID: MC00002687
PMOID: PMO:00017436
Subclass_of: Sulfonylurea Compounds
Synonym: 1-(P-Chlorobenzenesulfonyl)-3-propylurea
Synonym: 1-(P-Chlorophenylsulfonyl)-3-propylurea
Synonym: 1-Propyl-3-(P-chlorobenzenesulfonyl)urea
Synonym: Abemide
Synonym: Apo Chlorpropamide Tab 100mg
Synonym: Apo Chlorpropamide Tab 250mg
Synonym: Benzenesulfonamide, 4-chloro-N-((propylamino)carbonyl)-
Tree Number: T6.2.34.9.3
database_cross_reference: AOD:0000019646
database_cross_reference: ATC:A10BB02
database_cross_reference: CHV:0000002843
database_cross_reference: CSP:2841-3410
database_cross_reference: DRUGBANK:DB00672
database_cross_reference: LCH:U000982
database_cross_reference: LCH_NW:sh85024592
database_cross_reference: LNC:LP16075-1
database_cross_reference: LNC:MTHU003325
database_cross_reference: MMSL:4361
database_cross_reference: MMSL:4430
database_cross_reference: MMSL:d00042
database_cross_reference: MSH:D002747
database_cross_reference: MTHSPL:WTM2C3IL2X
database_cross_reference: NCI:C47447
database_cross_reference: NCI_FDA:WTM2C3IL2X
database_cross_reference: NDDF:000910
database_cross_reference: NDFRT:N0000006948
database_cross_reference: NDFRT:N0000146198
database_cross_reference: RCD:f32..
database_cross_reference: RXNORM:2404
database_cross_reference: SNM:E-8591
database_cross_reference: SNMI:C-A2420
database_cross_reference: SNOMEDCT_US:111154004
database_cross_reference: SNOMEDCT_US:386991003
database_cross_reference: USPMG:MTHU000831
database_cross_reference: VANDF:4017841

Glyburide
type: Class
subclass of: Sulfonylurea Compounds
MCID: MC00005628
PMOID: PMO:00017437
Subclass_of: Sulfonylurea Compounds
Synonym: 1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
Synonym: 1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
Synonym: Apo Glyburide Tab 2.5mg
Synonym: Apo Glyburide Tab 5mg
Synonym: Ava-glyburide
Synonym: Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-
Synonym: Delmide
Synonym: Diabeta 5mg
Synonym: Diabeta Tab 2.5mg
Tree Number: T6.2.34.9.4
database_cross_reference: ATC:A10BB01
database_cross_reference: CHV:0000005521
database_cross_reference: CSP:2841-5600
database_cross_reference: DRUGBANK:DB01016
database_cross_reference: LCH:U001973
database_cross_reference: LCH_NW:sh85055266
database_cross_reference: LNC:LP14720-4
database_cross_reference: LNC:MTHU001812
database_cross_reference: MEDCIN:41883
database_cross_reference: MMSL:4790
database_cross_reference: MMSL:597
database_cross_reference: MMSL:d00248
database_cross_reference: MSH:D005905
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:SX6K58TVWC
database_cross_reference: NCI:C29076
database_cross_reference: NCI_FDA:SX6K58TVWC
database_cross_reference: NDDF:000912
database_cross_reference: NDFRT:N0000006295
database_cross_reference: NDFRT:N0000146417
database_cross_reference: RCD:f33..
database_cross_reference: RXNORM:4815
database_cross_reference: SNMI:C-A2440
database_cross_reference: SNOMEDCT_US:384978002
database_cross_reference: SNOMEDCT_US:387466004
database_cross_reference: SNOMEDCT_US:80870001
database_cross_reference: USPMG:MTHU000834
database_cross_reference: VANDF:4018078

Gliclazide
type: Class
subclass of: Sulfonylurea Compounds
MCID: MC00005629
PMOID: PMO:00017438
Subclass_of: Sulfonylurea Compounds
Synonym: 1-(3-Azabicyclo(3.3.0)Oct-3-Yl)-3-(P-Tolylsulfonyl)Urea
Synonym: 1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea
Synonym: 1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea
Synonym: Apo-gliclazide
Synonym: Apo-gliclazide Mr
Synonym: Ava-gliclazide
Synonym: Benzenesulfonamide, N-(((hexahydrocyclopenta(c)pyrrol-2(1H)-yl)amino)carbonyl)-4-methyl-
Synonym: Diamicron Mr
Synonym: GLICLAZIDE
Synonym: Glic
Tree Number: T6.2.34.9.5
database_cross_reference: ATC:A10BB09
database_cross_reference: CHV:0000005522
database_cross_reference: DRUGBANK:DB01120
database_cross_reference: LCH:U001974
database_cross_reference: LCH_NW:sh85055268
database_cross_reference: LNC:LP173636-4
database_cross_reference: LNC:MTHU047394
database_cross_reference: MEDCIN:197572
database_cross_reference: MSH:D005907
database_cross_reference: NCI:C87618
database_cross_reference: NCI_FDA:G4PX8C4HKV
database_cross_reference: NDDF:003858
database_cross_reference: NDFRT:N0000166470
database_cross_reference: RCD:f35..
database_cross_reference: RXNORM:4816
database_cross_reference: SNOMEDCT_US:325238000
database_cross_reference: SNOMEDCT_US:395731001

Tolazamide
type: Class
subclass of: Sulfonylurea Compounds
MCID: MC00012895
PMOID: PMO:00017440
Subclass_of: Sulfonylurea Compounds
Synonym: 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea
Synonym: 1-(hexahydro-1-Azepinyl)-3-P-tolylsulfonylurea
Synonym: 1-(hexahydro-1H-Azepin-1-yl)-3-(P-tolylsulfonyl)urea
Synonym: 4-(P-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide
Synonym: 4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide
Synonym: Benzenesulfonamide, N-(((hexahydro-1H-azepin-1-yl)amino)carbonyl)-4-methyl-
Synonym: Desumide
Synonym: EINECS 214-588-3
Synonym: Esulin
Synonym: N-(P-Toluenesulfonyl)-n'-hexamethyleniminourea
Tree Number: T6.2.34.9.6
database_cross_reference: ATC:A10BB05
database_cross_reference: DRUGBANK:DB00839
database_cross_reference: LNC:LP17254-1
database_cross_reference: LNC:MTHU010006
database_cross_reference: MEDCIN:40373
database_cross_reference: MMSL:1119
database_cross_reference: MMSL:5593
database_cross_reference: MMSL:d00393
database_cross_reference: MSH:D014042
database_cross_reference: MTHSPL:9LT1BRO48Q
database_cross_reference: NCI:C29502
database_cross_reference: NCI_FDA:9LT1BRO48Q
database_cross_reference: NDDF:000911
database_cross_reference: NDFRT:N0000005916
database_cross_reference: NDFRT:N0000146187
database_cross_reference: RCD:f39..
database_cross_reference: RXNORM:10633
database_cross_reference: SNM:E-8595
database_cross_reference: SNMI:C-A2450
database_cross_reference: SNOMEDCT_US:34393009
database_cross_reference: SNOMEDCT_US:387186009
database_cross_reference: USPMG:MTHU000835
database_cross_reference: VANDF:4017829

Tolbutamide
type: Class
subclass of: Sulfonylurea Compounds
MCID: MC00012897
PMOID: PMO:00017441
Subclass_of: Sulfonylurea Compounds
Synonym: 1-Butyl-3-(P-methylphenylsulfonyl)urea
Synonym: 1-Butyl-3-(P-tolylsulfonyl)urea
Synonym: 1-Butyl-3-tosylurea
Synonym: 1-P-Toluenesulfonyl-3-butylurea
Synonym: 3-(P-Tolyl-4-sulfonyl)-1-butylurea
Synonym: Benzenesulfonamide, N-((butylamino)carbonyl)-4-methyl-
Synonym: Butamide
Synonym: Dirastan
Synonym: Mobenol Tablets 500mg
Synonym: N-(4-Methylbenzenesulfonyl)-n'-butylurea
Tree Number: T6.2.34.9.7
database_cross_reference: AOD:0000019647
database_cross_reference: ATC:A10BB03
database_cross_reference: ATC:V04CA01
database_cross_reference: CHV:0000012340
database_cross_reference: CSP:2841-5754
database_cross_reference: DRUGBANK:DB01124
database_cross_reference: LCH:U004714
database_cross_reference: LCH_NW:sh85135874
database_cross_reference: LNC:LP16296-3
database_cross_reference: LNC:LP32705-3
database_cross_reference: LNC:MTHU010007
database_cross_reference: MEDCIN:40374
database_cross_reference: MMSL:4482
database_cross_reference: MMSL:5595
database_cross_reference: MMSL:d00394
database_cross_reference: MSH:D014044
database_cross_reference: MTHSPL:982XCM1FOI
database_cross_reference: NCI:C66610
database_cross_reference: NCI_FDA:982XCM1FOI
database_cross_reference: NDDF:000908
database_cross_reference: NDFRT:N0000005923
database_cross_reference: NDFRT:N0000146241
database_cross_reference: RCD:f3a..
database_cross_reference: RXNORM:10635
database_cross_reference: SNM:E-8593
database_cross_reference: SNMI:C-A2460
database_cross_reference: SNOMEDCT_US:33124007
database_cross_reference: SNOMEDCT_US:373481003
database_cross_reference: USPMG:MTHU000836
database_cross_reference: VANDF:4017888

Sulfoxides
type: Class
subclass of: Sulfur Compounds
MCID: MC00012409
PMOID: PMO:00017442
Subclass_of: Sulfur Compounds
Synonym: Sulfoxides [Chemical/Ingredient]
Synonym: Sulphoxides
Synonym: sulfoxide
Tree Number: T6.2.32.10
database_cross_reference: AOD:0000019640
database_cross_reference: CHV:0000011873
database_cross_reference: LCH:U006202
database_cross_reference: LCH_NW:sh85130363
database_cross_reference: MSH:D013454
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008055

Dimethyl Sulfoxide
type: Class
subclass of: Sulfoxides
MCID: MC00003961
PMOID: PMO:00017443
Subclass_of: Sulfoxides
Synonym: (CH3)2SO
Synonym: (DMSO)
Synonym: DIMETHYL SULFOXIDE
Synonym: DMSO
Synonym: DMSO - Dimethylsulfoxide
Synonym: DMSO - Dimethylsulphoxide
Synonym: Dimethyl Sulfoxide Irrigation USP
Synonym: Dimethyl Sulfoxide [Chemical/Ingredient]
Synonym: Dimethyl Sulphoxide
Synonym: Dimethyl sulfoxide
Tree Number: T6.2.32.10.1
database_cross_reference: AOD:0000019641
database_cross_reference: AOD:0000028730
database_cross_reference: ATC:G04BX13
database_cross_reference: ATC:M02AX03
database_cross_reference: CHV:0000003966
database_cross_reference: CSP:2841-9966
database_cross_reference: DRUGBANK:DB01093
database_cross_reference: LCH:U005464
database_cross_reference: LCH_NW:sh85038040
database_cross_reference: LNC:LP18068-4
database_cross_reference: LNC:MTHU003331
database_cross_reference: MEDCIN:48752
database_cross_reference: MMSL:1614
database_cross_reference: MMSL:4608
database_cross_reference: MMSL:d01431
database_cross_reference: MSH:D004121
database_cross_reference: MTHSPL:YOW8V9698H
database_cross_reference: NCI:C437
database_cross_reference: NCI_DCP:00211
database_cross_reference: NCI_DTP:NSC0000763
database_cross_reference: NCI_FDA:YOW8V9698H
database_cross_reference: NCI_NCI-GLOSS:CDR0000044097
database_cross_reference: NDDF:002883
database_cross_reference: NDFRT:N0000006711
database_cross_reference: NDFRT:N0000147300
database_cross_reference: PDQ:CDR0000039222
database_cross_reference: RCD:XM0li
database_cross_reference: RCD:x0030
database_cross_reference: RCDAE:XM0li
database_cross_reference: RCDAE:x0030
database_cross_reference: RXNORM:3455
database_cross_reference: SNM:E-8997
database_cross_reference: SNMI:C-B7180
database_cross_reference: SNOMEDCT_US:115535002
database_cross_reference: SNOMEDCT_US:346400003
database_cross_reference: SNOMEDCT_US:66278004
database_cross_reference: VANDF:4019027

2-Pyridinylmethylsulfinylbenzimidazoles
type: Class
subclass of: Sulfoxides
subclass of: Pyridines
MCID: MC00583227
PMOID: PMO:00017444
Subclass_of: Pyridines
Subclass_of: Sulfoxides
Synonym: 2 Pyridinylmethylsulfinylbenzimidazoles
Synonym: 2-Pyridinylmethylsulfinylbenzimidazoles [Chemical/Ingredient]
Synonym: Benzimidazole Methylpyridine Sulfoxides
Synonym: Methylpyridine Sulfoxides, Benzimidazole
Synonym: PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES 02
Synonym: Sulfoxides, Benzimidazole Methylpyridine
Tree Number: T6.2.32.10.2
Tree Number: T6.3.5.20.33
database_cross_reference: MSH:D053799
database_cross_reference: NDFRT:N0000175098

Sulfenic Acids
type: Class
subclass of: Sulfur Acids
MCID: MC00012383
PMOID: PMO:00017450
Subclass_of: Sulfur Acids
Synonym: Acids, Sulfenic
Synonym: Sulfenic Acids [Chemical/Ingredient]
Synonym: Sulfenic acids
Synonym: sulfenic acid
Tree Number: T6.2.32.11.1
database_cross_reference: AOD:0000019635
database_cross_reference: LCH_NW:sh89005602
database_cross_reference: MSH:D013434
database_cross_reference: NDFRT:N0000166475

Pentosan Sulfuric Polyester
type: Class
subclass of: PMO:00020992
MCID: MC00009841
PMOID: PMO:00017453
Subclass_of: Polysaccharides
Synonym: Comfora
Synonym: Pentosan
Synonym: Pentosan Sulfuric Polyester [Chemical/Ingredient]
Synonym: Pentosan sulfuric polyester
Synonym: Pentosane Sulfuric Polyester
Synonym: Polyester, Pentosan Sulfuric
Synonym: Polyester, Pentosane Sulfuric
Synonym: Polypentose Sulfate
Synonym: Polysulfated Xylan
Synonym: Sulfate, Polypentose
Tree Number: T6.8.7.12
database_cross_reference: CHV:0000009442
database_cross_reference: CSP:2234-8636
database_cross_reference: DRUGBANK:DB00686
database_cross_reference: MSH:D010426
database_cross_reference: NCI:C946
database_cross_reference: NDFRT:N0000005728

Thiazines
type: Class
subclass of: Sulfur Compounds
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00012716
PMOID: PMO:00017455
Subclass_of: Heterocyclic Compounds, 1-Ring
Subclass_of: Sulfur Compounds
Synonym: Thiazine
Synonym: Thiazine (substance)
Synonym: Thiazines [Chemical/Ingredient]
Synonym: thiazine
Synonym: thiazines
Tree Number: T6.2.32.12
Tree Number: T6.3.5.23
database_cross_reference: AOD:0000020843
database_cross_reference: CHV:0000012177
database_cross_reference: CSP:2900-3405
database_cross_reference: LCH_NW:sh91001994
database_cross_reference: MSH:D013843
database_cross_reference: NDFRT:N0000008085
database_cross_reference: SNOMEDCT_US:421149006

Chlormezanone
type: Class
subclass of: Thiazines
MCID: MC00002656
PMOID: PMO:00017456
Subclass_of: Thiazines
Synonym: (+-)-Chlormezanone
Synonym: (Â±)-chlormezanone
Synonym: 2-(P-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
Synonym: 2-(P-Chlorphenyl)-3-methyl-1,3-perhydrothiazin-4-on-1,1-dioxide
Synonym: 4H-1,3-Thiazin-4-one, 2-(4-chlorophenyl)tetrahydro-3-methyl-, 1,1-dioxide
Synonym: CHLORMEZANONE
Synonym: Chlormethazanone
Synonym: Chlormezanona
Synonym: Chlormezanone (product)
Synonym: Chlormezanone (substance)
Tree Number: T6.2.32.12.2
Tree Number: T6.3.5.23.1
database_cross_reference: ATC:M03BB02
database_cross_reference: CHV:0000002826
database_cross_reference: DRUGBANK:DB01178
database_cross_reference: LNC:LP18105-4
database_cross_reference: LNC:MTHU003238
database_cross_reference: MEDCIN:41404
database_cross_reference: MMSL:4413
database_cross_reference: MMSL:d00909
database_cross_reference: MSH:D002720
database_cross_reference: NCI:C65316
database_cross_reference: NCI_FDA:GP568V9G19
database_cross_reference: NDDF:001447
database_cross_reference: NDFRT:N0000006870
database_cross_reference: NDFRT:N0000146590
database_cross_reference: RCD:d25..
database_cross_reference: RXNORM:2373
database_cross_reference: SNM:E-7908
database_cross_reference: SNMI:C-64230
database_cross_reference: SNOMEDCT_US:321267009
database_cross_reference: SNOMEDCT_US:387400008
database_cross_reference: SNOMEDCT_US:71634000
database_cross_reference: VANDF:4018260

Piroxicam
type: Class
subclass of: Thiazines
MCID: MC00010249
PMOID: PMO:00017457
Subclass_of: Thiazines
Synonym: 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide
Synonym: 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid
Synonym: 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboximide-1,1-dioxide
Synonym: Alti-piroxicam-cap 10mg
Synonym: Alti-piroxicam-cap 20mg
Synonym: Apo Piroxicam Cap 10mg
Synonym: Apo Piroxicam Cap 20mg
Synonym: Bruxicam
Synonym: Dolonex
Synonym: Dom-piroxicam
Tree Number: T6.2.32.12.4
Tree Number: T6.3.5.23.3
database_cross_reference: AOD:0000020844
database_cross_reference: ATC:M01AC01
database_cross_reference: ATC:M02AA07
database_cross_reference: ATC:S01BC06
database_cross_reference: CHV:0000009755
database_cross_reference: CSP:4001-0107
database_cross_reference: DRUGBANK:DB00554
database_cross_reference: LCH:U003689
database_cross_reference: LCH_NW:sh85102442
database_cross_reference: LNC:LP15181-8
database_cross_reference: LNC:MTHU001848
database_cross_reference: MEDCIN:40462
database_cross_reference: MMSL:1529
database_cross_reference: MMSL:5308
database_cross_reference: MMSL:d00343
database_cross_reference: MSH:D010894
database_cross_reference: MTHSPL:13T4O6VMAM
database_cross_reference: NCI:C751
database_cross_reference: NCI_DCP:00355
database_cross_reference: NCI_DTP:NSC0666076
database_cross_reference: NCI_FDA:13T4O6VMAM
database_cross_reference: NDDF:002389
database_cross_reference: NDFRT:N0000006196
database_cross_reference: NDFRT:N0000146939
database_cross_reference: PDQ:CDR0000039761
database_cross_reference: RCD:j2e..
database_cross_reference: RXNORM:8356
database_cross_reference: SNMI:C-60430
database_cross_reference: SNOMEDCT_US:27754002
database_cross_reference: SNOMEDCT_US:363618008
database_cross_reference: SNOMEDCT_US:387153005
database_cross_reference: USPMG:MTHU000074
database_cross_reference: VANDF:4018626

Thiadiazines
type: Class
subclass of: Thiazines
MCID: MC00012701
PMOID: PMO:00017458
Subclass_of: Thiazines
Synonym: Thiadiazines [Chemical/Ingredient]
Synonym: thiadiazine
Tree Number: T6.2.32.12.5
Tree Number: T6.3.5.23.4
database_cross_reference: CSP:2898-4675
database_cross_reference: MSH:D013829
database_cross_reference: NDFRT:N0000167142

Xylazine
type: Class
subclass of: Thiazines
MCID: MC00013769
PMOID: PMO:00017459
Subclass_of: Thiazines
Synonym: 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-
Synonym: XYLAZINE
Synonym: Xylaxine
Synonym: Xylazin
Synonym: Xylazine [Chemical/Ingredient]
Synonym: xylaxine
Synonym: xylazin
Synonym: xylazine
Tree Number: T6.2.32.12.6
Tree Number: T6.3.5.23.5
database_cross_reference: CHV:0000013240
database_cross_reference: LCH_NW:sh97003665
database_cross_reference: MSH:D014991
database_cross_reference: MTHSPL:2KFG9TP5V8
database_cross_reference: NCI:C75049
database_cross_reference: NCI_FDA:2KFG9TP5V8
database_cross_reference: NDFRT:N0000167143
database_cross_reference: RXNORM:1099660

Thiazoles
type: Class
subclass of: Sulfur Compounds
subclass of: Azoles
MCID: MC00012717
PMOID: PMO:00017460
Subclass_of: Azoles
Subclass_of: Sulfur Compounds
Synonym: Thiazole
Synonym: Thiazole (substance)
Synonym: Thiazoles [Chemical/Ingredient]
Synonym: thiazole
Synonym: thiazoles
Tree Number: T6.2.32.13
Tree Number: T6.3.5.6.7
database_cross_reference: AOD:0000020845
database_cross_reference: CHV:0000012178
database_cross_reference: CSP:2900-7151
database_cross_reference: LCH:U004651
database_cross_reference: LCH_NW:sh85134844
database_cross_reference: MSH:D013844
database_cross_reference: NDFRT:N0000008087
database_cross_reference: SNOMEDCT_US:428162000

Lurasidone Hydrochloride
type: Class
subclass of: Thiazoles
MCID: MC00740102
PMOID: PMO:00017461
Subclass_of: Thiazoles
Synonym: HCl, Lurasidone
Synonym: Hydrochloride, Lurasidone
Synonym: LURASIDONE HYDROCHLORIDE
Synonym: Lurasidone HCl
Synonym: Lurasidone Hydrochloride [Chemical/Ingredient]
Synonym: Lurasidone hydrochloride
Synonym: Lurasidone hydrochloride (substance)
Synonym: lurasidone HCl
Synonym: lurasidone hydrochloride
Tree Number: T6.2.32.13.1
database_cross_reference: MMSL:27589
database_cross_reference: MSH:D000069056
database_cross_reference: MTHSPL:O0P4I5851I
database_cross_reference: NCI:C77576
database_cross_reference: NCI_FDA:O0P4I5851I
database_cross_reference: NDDF:013607
database_cross_reference: NDFRT:N0000182252
database_cross_reference: NDFRT:N0000191973
database_cross_reference: RXNORM:1040027
database_cross_reference: SNOMEDCT_US:703116009
database_cross_reference: VANDF:4030294

Dasatinib
type: Class
subclass of: Thiazoles
subclass of: Pyrimidines
MCID: MC00519641
PMOID: PMO:00017462
Subclass_of: Pyrimidines
Subclass_of: Thiazoles
Synonym: BMS dasatinib
Synonym: DASATINIB
Synonym: Dasatinib (product)
Synonym: Dasatinib (substance)
Synonym: Dasatinib [Chemical/Ingredient]
Synonym: Dasatinibum
Synonym: N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Synonym: dasatinib
Synonym: dasatinib (medication)
Tree Number: T6.2.32.13.2
Tree Number: T6.3.5.21.5
database_cross_reference: ATC:L01XE06
database_cross_reference: DRUGBANK:DB01254
database_cross_reference: MEDCIN:302447
database_cross_reference: MMSL:21648
database_cross_reference: MMSL:d05831
database_cross_reference: MSH:D000069439
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:RBZ1571X5H
database_cross_reference: NCI:C38713
database_cross_reference: NCI_DCP:32181
database_cross_reference: NCI_FDA:RBZ1571X5H
database_cross_reference: NCI_NCI-GLOSS:CDR0000484435
database_cross_reference: NDDF:011616
database_cross_reference: NDFRT:N0000176043
database_cross_reference: NDFRT:N0000179780
database_cross_reference: PDQ:CDR0000315885
database_cross_reference: RXNORM:475342
database_cross_reference: SNOMEDCT_US:422756008
database_cross_reference: SNOMEDCT_US:423658008
database_cross_reference: USPMG:MTHU002518
database_cross_reference: VANDF:4025488

Febuxostat
type: Class
subclass of: Thiazoles
MCID: MC00083582
PMOID: PMO:00017463
Subclass_of: Thiazoles
Synonym: 2-(3-Cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylic Acid
Synonym: 2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acid
Synonym: 5-Thiazolecarboxylic acid, 2-(3-cyano-4-(2-methylpropoxy)phenyl)-4-methyl-
Synonym: Atenurix
Synonym: Barif
Synonym: FEBUXOSTAT
Synonym: Feburic
Synonym: Febuxostat (medication)
Synonym: Febuxostat (product)
Synonym: Febuxostat (substance)
Tree Number: T6.2.32.13.3
database_cross_reference: ATC:M04AA03
database_cross_reference: DRUGBANK:DB04854
database_cross_reference: MEDCIN:304534
database_cross_reference: MMSL:26212
database_cross_reference: MMSL:d07397
database_cross_reference: MSH:D000069465
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:101V0R1N2E
database_cross_reference: NCI:C65629
database_cross_reference: NCI_FDA:101V0R1N2E
database_cross_reference: NDDF:012966
database_cross_reference: NDFRT:N0000171777
database_cross_reference: NDFRT:N0000179385
database_cross_reference: RXNORM:73689
database_cross_reference: SNOMEDCT_US:441610003
database_cross_reference: SNOMEDCT_US:441743008
database_cross_reference: USPMG:MTHU002406
database_cross_reference: VANDF:4025245

Chlormethiazole
type: Class
subclass of: Thiazoles
MCID: MC00002655
PMOID: PMO:00017464
Subclass_of: Thiazoles
Synonym: CLOMETHIAZOLE
Synonym: Chlormethiazole (product)
Synonym: Chlormethiazole (substance)
Synonym: Chlormethiazole [Chemical/Ingredient]
Synonym: Clomethiazole
Synonym: Clomethiazole (substance)
Synonym: Thiazole, 5-(2-chloroethyl)-4-methyl-
Synonym: Zendra
Synonym: chlormethiazole
Synonym: clomethiazole
Tree Number: T6.2.32.13.5
database_cross_reference: AOD:0000020726
database_cross_reference: AOD:0000029037
database_cross_reference: ATC:N05CM02
database_cross_reference: CHV:0000002825
database_cross_reference: DRUGBANK:DB06470
database_cross_reference: MEDCIN:198855
database_cross_reference: MSH:D002719
database_cross_reference: NCI:C80664
database_cross_reference: NCI_FDA:0C5DBZ19HV
database_cross_reference: NDDF:003691
database_cross_reference: NDFRT:N0000167093
database_cross_reference: RCD:x02LL
database_cross_reference: RXNORM:2372
database_cross_reference: SNOMEDCT_US:354039005
database_cross_reference: SNOMEDCT_US:395978007
database_cross_reference: SNOMEDCT_US:417894008

Dithiazanine
type: Class
subclass of: Thiazoles
MCID: MC00004074
PMOID: PMO:00017465
Subclass_of: Thiazoles
Synonym: 3,3' Diethylthiadicarbocyanine
Synonym: 3,3'-Diethylthiadicarbocyanine
Synonym: Benzothiazolium, 3-ethyl-2-(5-(3-ethyl-2(3H)-benzothiazolylidene)-1,3-pentadienyl)-
Synonym: DITHIAZANINE
Synonym: Dithiazanine [Chemical/Ingredient]
Synonym: dithiazanine
Tree Number: T6.2.32.13.6
database_cross_reference: MSH:D004225
database_cross_reference: NCI:C72743
database_cross_reference: NCI_FDA:5L7E7IY5EH
database_cross_reference: NDDF:004970
database_cross_reference: NDFRT:N0000167095
database_cross_reference: SNM:E-7413
database_cross_reference: SNOMEDCT_US:89701003

Levamisole
type: Class
subclass of: Thiazoles
MCID: MC00007535
PMOID: PMO:00017466
Subclass_of: Thiazoles
Synonym: (S)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole
Synonym: Ergamisol Tab 50mg
Synonym: Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (S)-
Synonym: L-Tetramisole
Synonym: LEV
Synonym: LEVAMISOLE
Synonym: LMS
Synonym: Levamisol
Synonym: Levamisole (product)
Synonym: Levamisole (substance)
Tree Number: T6.2.32.13.9
database_cross_reference: ATC:P02CE01
database_cross_reference: CHV:0000007375
database_cross_reference: CSP:1549-4587
database_cross_reference: DRUGBANK:DB00848
database_cross_reference: LCH:U002673
database_cross_reference: LCH_NW:sh85076310
database_cross_reference: LNC:LP100040-7
database_cross_reference: LNC:MTHU035824
database_cross_reference: MMSL:d00276
database_cross_reference: MSH:D007978
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2880D3468G
database_cross_reference: NCI:C61609
database_cross_reference: NCI_FDA:2880D3468G
database_cross_reference: NCI_NCI-GLOSS:CDR0000045157
database_cross_reference: NDDF:004809
database_cross_reference: NDFRT:N0000006679
database_cross_reference: NDFRT:N0000147645
database_cross_reference: PDQ:CDR0000039058
database_cross_reference: RCD:x02MJ
database_cross_reference: RXNORM:6371
database_cross_reference: SNM:E-7420
database_cross_reference: SNMI:C-56A96
database_cross_reference: SNOMEDCT_US:387296006
database_cross_reference: SNOMEDCT_US:54391004
database_cross_reference: VANDF:4019531

Niridazole
type: Class
subclass of: Thiazoles
MCID: MC00008912
PMOID: PMO:00017467
Subclass_of: Thiazoles
Synonym: 2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-
Synonym: NIRIDAZOLE
Synonym: Niridazole (substance)
Synonym: Niridazole [Chemical/Ingredient]
Synonym: niridazole
Synonym: niridazole (medication)
Tree Number: T6.2.32.13.10
database_cross_reference: ATC:P02BX02
database_cross_reference: MEDCIN:40421
database_cross_reference: MSH:D009560
database_cross_reference: NCI:C90757
database_cross_reference: NCI_FDA:N116U8Y5QQ
database_cross_reference: NDDF:006108
database_cross_reference: NDFRT:N0000167099
database_cross_reference: SNM:E-7435
database_cross_reference: SNMI:C-56760
database_cross_reference: SNOMEDCT_US:55944008

Oxythiamine
type: Class
subclass of: Thiazoles
MCID: MC00009596
PMOID: PMO:00017468
Subclass_of: Thiazoles
Synonym: Hydroxythiamine
Synonym: Oxythiamine [Chemical/Ingredient]
Synonym: Thiazolium, 3-((1,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-
Tree Number: T6.2.32.13.11
database_cross_reference: MSH:D010119
database_cross_reference: NDFRT:N0000167098

Rhodanine
type: Class
subclass of: Thiazoles
MCID: MC00011372
PMOID: PMO:00017469
Subclass_of: Thiazoles
Synonym: 4-Thiazolidinone, 2-thioxo-
Synonym: Rhodanine [Chemical/Ingredient]
Tree Number: T6.2.32.13.12
database_cross_reference: MSH:D012236
database_cross_reference: NDFRT:N0000167092

Saccharin
type: Class
subclass of: Thiazoles
MCID: MC00011540
PMOID: PMO:00017470
Subclass_of: Thiazoles
Synonym: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide
Synonym: 1,2-Benzisothiazolin-3-one, 1,1-dioxide
Synonym: 1,2-Dihydro-2-ketobenzisosulphonazole
Synonym: 2,3-Dihydro-3-oxobenzisosulfonazole
Synonym: Benzoic Sulphimide
Synonym: Benzosulfimide
Synonym: Benzosulphimide
Synonym: SACCHARIN
Synonym: Saccharin (product)
Synonym: Saccharin (substance)
Tree Number: T6.2.32.13.13
database_cross_reference: AOD:0000019429
database_cross_reference: CHV:0000010983
database_cross_reference: DRUGBANK:DB12418
database_cross_reference: LCH:U004181
database_cross_reference: LCH_NW:sh85116223
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D012439
database_cross_reference: MTHSPL:FST467XS7D
database_cross_reference: NCI:C76515
database_cross_reference: NCI_FDA:FST467XS7D
database_cross_reference: NDDF:002600
database_cross_reference: NDFRT:N0000005967
database_cross_reference: NDFRT:N0000146449
database_cross_reference: PSY:45050
database_cross_reference: RCD:Ub0eG
database_cross_reference: RXNORM:9509
database_cross_reference: SNM:E-8747
database_cross_reference: SNMI:C-F1064
database_cross_reference: SNOMEDCT_US:27138006
database_cross_reference: SNOMEDCT_US:422323005
database_cross_reference: VANDF:4018111

Tetramisole
type: Class
subclass of: Thiazoles
MCID: MC00012668
PMOID: PMO:00017471
Subclass_of: Thiazoles
Synonym: (+/-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole
Synonym: Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (+-)-
Synonym: Nilverm Base
Synonym: TETRAMISOLE
Synonym: Tetramisole [Chemical/Ingredient]
Synonym: dl-Tetramisole
Tree Number: T6.2.32.13.15
database_cross_reference: MSH:D013773
database_cross_reference: NCI:C95050
database_cross_reference: NCI_FDA:C8M7RFE4NO
database_cross_reference: NDFRT:N0000167097
database_cross_reference: SNM:E-7419
database_cross_reference: SNMI:C-56A96
database_cross_reference: SNOMEDCT_US:387296006
database_cross_reference: SNOMEDCT_US:54391004

Thiabendazole
type: Class
subclass of: Thiazoles
MCID: MC00012699
PMOID: PMO:00017472
Subclass_of: Thiazoles
Synonym: 1H-Benzimidazole, 2-(4-thiazolyl)-
Synonym: 2-(1,3-THIAZOL-4-yl)-1H-benzimidazole
Synonym: 2-(4'-Thiazolyl)Benzimidazole
Synonym: 4-(2-Benzimidazolyl)thiazole
Synonym: Mintezol Chewable Tab 500mg
Synonym: TBDZ
Synonym: TBZ
Synonym: THIABENDAZOLE
Synonym: Thiabendazole (product)
Synonym: Thiabendazole (substance)
Tree Number: T6.2.32.13.16
database_cross_reference: ATC:D01AC06
database_cross_reference: ATC:P02CA02
database_cross_reference: CHV:0000012170
database_cross_reference: DRUGBANK:DB00730
database_cross_reference: MEDCIN:40424
database_cross_reference: MMSL:5565
database_cross_reference: MMSL:80871
database_cross_reference: MMSL:d00160
database_cross_reference: MSH:D013827
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:N1Q45E87DT
database_cross_reference: NCI:C873
database_cross_reference: NCI_FDA:N1Q45E87DT
database_cross_reference: NDDF:002985
database_cross_reference: NDFRT:N0000007132
database_cross_reference: NDFRT:N0000146305
database_cross_reference: PDQ:CDR0000039713
database_cross_reference: RCD:ex1..
database_cross_reference: RXNORM:10450
database_cross_reference: SNM:E-7427
database_cross_reference: SNMI:C-56A80
database_cross_reference: SNOMEDCT_US:36594001
database_cross_reference: SNOMEDCT_US:387198004
database_cross_reference: SNOMEDCT_US:416624006
database_cross_reference: VANDF:4017955

Thiadiazoles
type: Class
subclass of: Thiazoles
MCID: MC00012702
PMOID: PMO:00017473
Subclass_of: Thiazoles
Synonym: Thiadiazoles [Chemical/Ingredient]
Tree Number: T6.2.32.13.17
database_cross_reference: LCH_NW:sh2004007280
database_cross_reference: MSH:D013830
database_cross_reference: NDFRT:N0000008081

Thiamine
type: Class
subclass of: Thiazoles
subclass of: Pyrimidines
MCID: MC00012703
PMOID: PMO:00017476
Subclass_of: Pyrimidines
Subclass_of: Thiazoles
Synonym: 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethanol
Synonym: 3-(4-AMINO-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium
Synonym: Acti-MN + B1 + C Caplet
Synonym: Acti-thiamine Caplet 100mg
Synonym: Adult Infuvite Multiple Vitamins
Synonym: Alertonic
Synonym: Allbee With C 550 Cap
Synonym: Allbee With Vitamin C Cap
Synonym: Alsimine W Vitamins A D
Synonym: Am Caps
Tree Number: T6.2.32.13.18
Tree Number: T6.3.5.21.21
database_cross_reference: AOD:0000004766
database_cross_reference: ATC:A11DA01
database_cross_reference: CHV:0000012172
database_cross_reference: CSP:3147-2928
database_cross_reference: DRUGBANK:DB00152
database_cross_reference: LCH_NW:sh85143962
database_cross_reference: LNC:LP15886-2
database_cross_reference: LNC:MTHU008943
database_cross_reference: MEDCIN:41296
database_cross_reference: MEDLINEPLUS:5376
database_cross_reference: MMSL:1096
database_cross_reference: MMSL:5681
database_cross_reference: MMSL:d03130
database_cross_reference: MSH:D013831
database_cross_reference: MTH:U002296
database_cross_reference: MTHSPL:X66NSO3N35
database_cross_reference: NCI:C874
database_cross_reference: NCI_CRCH:C874
database_cross_reference: NCI_DCP:05001
database_cross_reference: NCI_FDA:X66NSO3N35
database_cross_reference: NCI_NCI-GLOSS:CDR0000556404
database_cross_reference: NCI_NCI-GLOSS:CDR0000629163
database_cross_reference: NDDF:001061
database_cross_reference: NDFRT:N0000007147
database_cross_reference: NDFRT:N0000145862
database_cross_reference: NDFRT:N0000146138
database_cross_reference: PDQ:CDR0000037856
database_cross_reference: RCD:X80RQ
database_cross_reference: RCD:x01PQ
database_cross_reference: RXNORM:10454
database_cross_reference: SNM:F-16210
database_cross_reference: SNMI:C-A4460
database_cross_reference: SNMI:F-BB310
database_cross_reference: SNOMEDCT_US:259659006
database_cross_reference: SNOMEDCT_US:30306003
database_cross_reference: SNOMEDCT_US:61768002
database_cross_reference: VANDF:4017474
database_cross_reference: VANDF:4017777

Thiamine Pyrophosphate
type: Class
subclass of: Coenzymes
MCID: MC00012708
PMOID: PMO:00017479
Subclass_of: Coenzymes
Synonym: COCARBOXYLASE
Synonym: Cocarboxylase
Synonym: Pyrophosphate, Thiamine
Synonym: Pyrophosphoric Ester of Thiamine
Synonym: TPP
Synonym: Thiamin pyrophosphate
Synonym: Thiamine Diphosphate
Synonym: Thiamine Pyrophosphate [Chemical/Ingredient]
Synonym: Thiamine diphosphate
Synonym: Thiamine pyrophosphate
Tree Number: T6.7.1.11
database_cross_reference: AOD:0000018241
database_cross_reference: CHV:0000012175
database_cross_reference: CSP:3147-3477
database_cross_reference: DRUGBANK:DB01987
database_cross_reference: LCH_NW:sh87001972
database_cross_reference: LNC:LP15887-0
database_cross_reference: LNC:MTHU014005
database_cross_reference: MEDCIN:199129
database_cross_reference: MEDCIN:41274
database_cross_reference: MSH:D013835
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:Q57971654Y
database_cross_reference: NCI:C81632
database_cross_reference: NCI_FDA:Q57971654Y
database_cross_reference: NDDF:001063
database_cross_reference: NDFRT:N0000168400
database_cross_reference: RCD:X80RT
database_cross_reference: RXNORM:10459
database_cross_reference: SNM:F-16210
database_cross_reference: SNM:F-20890
database_cross_reference: SNMI:F-BB310
database_cross_reference: SNOMEDCT_US:259661002
database_cross_reference: SNOMEDCT_US:61768002

Famotidine
type: Class
subclass of: Thiazoles
MCID: MC00004959
PMOID: PMO:00017481
Subclass_of: Thiazoles
Synonym: 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide
Synonym: 3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine
Synonym: 7 Select Acid Controller
Synonym: Acid Control
Synonym: Acid Control Original Strength
Synonym: Acid Controller Complete
Synonym: Acid Controller Complete dual action
Synonym: Acid Controller Maximum Strength
Synonym: Acid Controller Original Strength
Tree Number: T6.2.32.13.19
database_cross_reference: AOD:0000020846
database_cross_reference: ATC:A02BA03
database_cross_reference: CHV:0000004890
database_cross_reference: DRUGBANK:DB00927
database_cross_reference: LNC:LP14346-8
database_cross_reference: LNC:MTHU011541
database_cross_reference: MEDCIN:41926
database_cross_reference: MMSL:41331
database_cross_reference: MMSL:4713
database_cross_reference: MMSL:d00141
database_cross_reference: MSH:D015738
database_cross_reference: MTHSPL:5QZO15J2Z8
database_cross_reference: MTHSPL:92PSG83J8A
database_cross_reference: NCI:C29045
database_cross_reference: NCI_FDA:5QZO15J2Z8
database_cross_reference: NDDF:003417
database_cross_reference: NDFRT:N0000006373
database_cross_reference: NDFRT:N0000146320
database_cross_reference: RCD:a68..
database_cross_reference: RXNORM:4278
database_cross_reference: SNMI:C-84020
database_cross_reference: SNOMEDCT_US:387211002
database_cross_reference: SNOMEDCT_US:39128000
database_cross_reference: USPMG:MTHU001191
database_cross_reference: VANDF:4017970

Nizatidine
type: Class
subclass of: Thiazoles
MCID: MC00043174
PMOID: PMO:00017482
Subclass_of: Thiazoles
Synonym: 1,1-Ethenediamine, N-(2-(((2-((dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-
Synonym: Acinon
Synonym: Apo-nizatidine
Synonym: Dom-nizatidine 150mg Capsules
Synonym: Gen-nizatidine
Synonym: N-(2-(((2-((Dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine
Synonym: NIZATIDINE
Synonym: Nizatidina
Synonym: Nizatidine (product)
Synonym: Nizatidine (substance)
Tree Number: T6.2.32.13.20
database_cross_reference: ATC:A02BA04
database_cross_reference: CHV:0000015465
database_cross_reference: DRUGBANK:DB00585
database_cross_reference: LNC:LP19170-7
database_cross_reference: LNC:MTHU007483
database_cross_reference: MEDCIN:41904
database_cross_reference: MMSL:44069
database_cross_reference: MMSL:5184
database_cross_reference: MMSL:d00322
database_cross_reference: MSH:D016567
database_cross_reference: MTHSPL:P41PML4GHR
database_cross_reference: NCI:C29295
database_cross_reference: NCI_FDA:P41PML4GHR
database_cross_reference: NDDF:003418
database_cross_reference: NDFRT:N0000007324
database_cross_reference: NDFRT:N0000147517
database_cross_reference: RCD:a69..
database_cross_reference: RXNORM:42319
database_cross_reference: SNOMEDCT_US:108664005
database_cross_reference: SNOMEDCT_US:386887009
database_cross_reference: USPMG:MTHU001192
database_cross_reference: VANDF:4019342

Ritonavir
type: Class
subclass of: Thiazoles
MCID: MC00102108
PMOID: PMO:00017483
Subclass_of: Thiazoles
Synonym: RIT
Synonym: RITONAVIR
Synonym: RTV
Synonym: Ritonavir (product)
Synonym: Ritonavir (substance)
Synonym: Ritonavir [Chemical/Ingredient]
Synonym: Ritonavirum
Synonym: ritonavir
Synonym: ritonavir (medication)
Tree Number: T6.2.32.13.21
database_cross_reference: ATC:J05AE03
database_cross_reference: CHV:0000027775
database_cross_reference: CSP:4009-0059
database_cross_reference: DRUGBANK:DB00503
database_cross_reference: LNC:LP21314-7
database_cross_reference: LNC:MTHU013855
database_cross_reference: MEDCIN:72094
database_cross_reference: MMSL:5431
database_cross_reference: MMSL:d03984
database_cross_reference: MSH:D019438
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:O3J8G9O825
database_cross_reference: NCI:C1609
database_cross_reference: NCI_DCP:32207
database_cross_reference: NCI_DTP:NSC0693184
database_cross_reference: NCI_FDA:O3J8G9O825
database_cross_reference: NCI_NCI-GLOSS:CDR0000045535
database_cross_reference: NDDF:005554
database_cross_reference: NDFRT:N0000007423
database_cross_reference: NDFRT:N0000148436
database_cross_reference: PDQ:CDR0000042665
database_cross_reference: RCD:eiF..
database_cross_reference: RXNORM:85762
database_cross_reference: SNOMEDCT_US:108693005
database_cross_reference: SNOMEDCT_US:386896009
database_cross_reference: USPMG:MTHU000683
database_cross_reference: VANDF:4020963

Riluzole
type: Class
subclass of: Thiazoles
MCID: MC00036875
PMOID: PMO:00017484
Subclass_of: Thiazoles
Synonym: 2 Amino 6 trifluoromethoxybenzothiazole
Synonym: 2-Amino-6-(trifluoromethoxy)benzothiazole
Synonym: 2-Amino-6-trifluoromethoxybenzothiazole
Synonym: Apo-riluzole
Synonym: Fanizan
Synonym: Laidec
Synonym: Lizolorol
Synonym: Lizorolol
Synonym: Mylan-riluzole
Synonym: RILUZOLE
Tree Number: T6.2.32.13.22
database_cross_reference: ATC:N07XX02
database_cross_reference: CHV:0000014761
database_cross_reference: DRUGBANK:DB00740
database_cross_reference: MEDCIN:71072
database_cross_reference: MMSL:162294
database_cross_reference: MMSL:5425
database_cross_reference: MMSL:d03869
database_cross_reference: MSH:D019782
database_cross_reference: MTHSPL:7LJ087RS6F
database_cross_reference: NCI:C47704
database_cross_reference: NCI_FDA:7LJ087RS6F
database_cross_reference: NCI_NCI-GLOSS:CDR0000631054
database_cross_reference: NDDF:005183
database_cross_reference: NDFRT:N0000006860
database_cross_reference: NDFRT:N0000148421
database_cross_reference: RCD:dx1..
database_cross_reference: RXNORM:35623
database_cross_reference: SNOMEDCT_US:109141001
database_cross_reference: SNOMEDCT_US:386980005
database_cross_reference: USPMG:MTHU001093
database_cross_reference: VANDF:4020941

Thiazolidinediones
type: Class
subclass of: Thiazoles
MCID: MC00421667
PMOID: PMO:00017485
Subclass_of: Thiazoles
Synonym: Glitazones
Synonym: Thiazolidinedione
Synonym: Thiazolidinedione (product)
Synonym: Thiazolidinedione (substance)
Synonym: Thiazolidinediones [Chemical/Ingredient]
Synonym: glitazone
Synonym: glitazones
Synonym: thiazolidinedione
Synonym: thiazolidinediones
Synonym: thiazolidinediones (medication)
Tree Number: T6.2.32.13.23
database_cross_reference: CHV:0000056281
database_cross_reference: DRUGBANK:DB11898
database_cross_reference: MEDCIN:194703
database_cross_reference: MSH:D045162
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000011272
database_cross_reference: SNOMEDCT_US:109086001
database_cross_reference: SNOMEDCT_US:372568004

Firefly Luciferin
type: Class
subclass of: Thiazoles
PMOID: PMO:00017486
Subclass_of: Thiazoles
Tree Number: T6.2.32.13.24

Thiazolidines
type: Class
subclass of: Thiazoles
MCID: MC00583224
PMOID: PMO:00017487
Subclass_of: Thiazoles
Synonym: Thiazolidines [Chemical/Ingredient]
Tree Number: T6.2.32.13.25
database_cross_reference: MSH:D053778
database_cross_reference: NDFRT:N0000175099

Thiepins
type: Class
subclass of: Sulfur Compounds
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00012719
PMOID: PMO:00017488
Subclass_of: Heterocyclic Compounds, 1-Ring
Subclass_of: Sulfur Compounds
Synonym: Thiepins [Chemical/Ingredient]
Tree Number: T6.2.32.14
Tree Number: T6.3.5.24
database_cross_reference: LCH_NW:sh2007002602
database_cross_reference: MSH:D013846
database_cross_reference: NDFRT:N0000167197

Dibenzothiepins
type: Class
subclass of: Thiepins
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00003843
PMOID: PMO:00017489
Subclass_of: Heterocyclic Compounds, 3-Ring
Subclass_of: Thiepins
Synonym: Dibenzothiepin
Synonym: Dibenzothiepin (substance)
Synonym: Dibenzothiepins [Chemical/Ingredient]
Tree Number: T6.2.32.14.1
Tree Number: T6.3.1.2.13
database_cross_reference: MSH:D003988
database_cross_reference: NDFRT:N0000167274
database_cross_reference: SNM:E-7956
database_cross_reference: SNMI:C-62142
database_cross_reference: SNOMEDCT_US:16318005

Thiazepines
type: Class
subclass of: Thiepins
subclass of: Azepines
MCID: MC00012714
PMOID: PMO:00017492
Subclass_of: Azepines
Subclass_of: Thiepins
Synonym: Thiazepines [Chemical/Ingredient]
Synonym: thiazepine
Synonym: thiazepines
Tree Number: T6.2.32.14.2
Tree Number: T6.3.5.2.6
Tree Number: T6.3.5.24.1
database_cross_reference: CHV:0000012176
database_cross_reference: MSH:D013841
database_cross_reference: NDFRT:N0000167251

Dibenzothiazepines
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00003842
PMOID: PMO:00017493
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Dibenzothiazepines [Chemical/Ingredient]
Tree Number: T6.3.1.2.12
database_cross_reference: MSH:D003987
database_cross_reference: NDFRT:N0000007965

Thioglycosides
type: Class
subclass of: Sulfur Compounds
subclass of: PMO:00020950
MCID: MC00012734
PMOID: PMO:00017495
Subclass_of: Glycosides
Subclass_of: Sulfur Compounds
Synonym: Thioglycosides [Chemical/Ingredient]
Tree Number: T6.2.32.18
Tree Number: T6.8.6.17
database_cross_reference: MSH:D013865
database_cross_reference: NDFRT:N0000168441

Thiogalactosides
type: Class
subclass of: Thioglycosides
subclass of: PMO:00020971
MCID: MC00012731
PMOID: PMO:00017496
Subclass_of: Galactosides
Subclass_of: Thioglycosides
Synonym: Thiogalactopyranosides
Synonym: Thiogalactosides [Chemical/Ingredient]
Tree Number: T6.2.32.18.4
Tree Number: T6.8.6.17.1
Tree Number: T6.8.6.6.3
database_cross_reference: MSH:D013862
database_cross_reference: NDFRT:N0000168471

Thioglucosides
type: Class
subclass of: Thioglycosides
subclass of: PMO:00020974
MCID: MC00012732
PMOID: PMO:00017498
Subclass_of: Glucosides
Subclass_of: Thioglycosides
Synonym: Thioglucopyranosides
Synonym: Thioglucosides [Chemical/Ingredient]
Tree Number: T6.2.32.18.5
Tree Number: T6.8.6.17.2
Tree Number: T6.8.6.7.9
database_cross_reference: MSH:D013863
database_cross_reference: NDFRT:N0000168442

Thionucleosides
type: Class
subclass of: Sulfur Compounds
subclass of: PMO:00020982
MCID: MC00012741
PMOID: PMO:00017500
Subclass_of: Nucleosides
Subclass_of: Sulfur Compounds
Synonym: Thionucleosides [Chemical/Ingredient]
Tree Number: T6.11.3.6
Tree Number: T6.2.32.20
database_cross_reference: MSH:D013872
database_cross_reference: NDFRT:N0000170635

Azathioprine
type: Class
subclass of: Thionucleosides
MCID: MC00001433
PMOID: PMO:00017501
Subclass_of: Thionucleosides
Synonym: 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-
Synonym: 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine
Synonym: 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine
Synonym: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine
Synonym: ATP
Synonym: AZA
Synonym: AZATHIOPRINE
Synonym: AZT - Azathioprine
Synonym: AZTP
Synonym: Apo-azathioprine
Tree Number: T6.11.3.6.1
Tree Number: T6.2.32.20.1
database_cross_reference: ATC:L04AX01
database_cross_reference: CHV:0000001638
database_cross_reference: CSP:2910-8851
database_cross_reference: DRUGBANK:DB00993
database_cross_reference: LNC:LP18898-4
database_cross_reference: LNC:MTHU006794
database_cross_reference: MEDCIN:40132
database_cross_reference: MMSL:4234
database_cross_reference: MMSL:6041
database_cross_reference: MMSL:d00024
database_cross_reference: MSH:D001379
database_cross_reference: MTH:U001722
database_cross_reference: MTHSPL:MRK240IY2L
database_cross_reference: NCI:C290
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_DCP:00948
database_cross_reference: NCI_FDA:MRK240IY2L
database_cross_reference: NDDF:003419
database_cross_reference: NDFRT:N0000005799
database_cross_reference: NDFRT:N0000147069
database_cross_reference: PDQ:CDR0000039157
database_cross_reference: RCD:aa1..
database_cross_reference: RCD:h71..
database_cross_reference: RCD:x02MI
database_cross_reference: RXNORM:1256
database_cross_reference: SNM:E-7601
database_cross_reference: SNMI:C-B7040
database_cross_reference: SNOMEDCT_US:111165009
database_cross_reference: SNOMEDCT_US:317390007
database_cross_reference: SNOMEDCT_US:327060009
database_cross_reference: SNOMEDCT_US:372574004
database_cross_reference: SNOMEDCT_US:391800005
database_cross_reference: USPMG:MTHU001491
database_cross_reference: VANDF:4018766

Thioinosine
type: Class
subclass of: Thionucleosides
MCID: MC00012737
PMOID: PMO:00017502
Subclass_of: Thionucleosides
Synonym: 6 Mercaptopurine Riboside
Synonym: 6-MP riboside
Synonym: 6-MP-R
Synonym: 6-MPR
Synonym: 6-Mercaptopurine Riboside
Synonym: 6-Mercaptopurine ribonucleoside
Synonym: 6-Mercaptopurine riboside
Synonym: 6-mercaptopurine ribonucleoside
Synonym: 6-mercaptopurine riboside
Synonym: Inosine, 6-thio-
Tree Number: T6.11.3.6.2
Tree Number: T6.2.32.20.2
database_cross_reference: MSH:D013868
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C877
database_cross_reference: NCI_DTP:NSC0004911
database_cross_reference: NCI_FDA:46S541971T
database_cross_reference: NDFRT:N0000170642
database_cross_reference: PDQ:CDR0000039496

Thiouridine
type: Class
subclass of: Thionucleosides
MCID: MC00012764
PMOID: PMO:00017504
Subclass_of: Thionucleosides
Synonym: 4 Thiouridine
Synonym: 4-Thiouridine
Synonym: Thiouridine [Chemical/Ingredient]
Synonym: Uridine, 4-thio-
Tree Number: T6.11.3.6.3
Tree Number: T6.2.32.20.3
database_cross_reference: MSH:D013891
database_cross_reference: NDFRT:N0000170639

Thionucleotides
type: Class
subclass of: Sulfur Compounds
subclass of: PMO:00020983
MCID: MC00012742
PMOID: PMO:00017505
Subclass_of: Nucleotides
Subclass_of: Sulfur Compounds
Synonym: Thionucleotides [Chemical/Ingredient]
Tree Number: T6.11.4.8
Tree Number: T6.2.32.21
database_cross_reference: MSH:D013873
database_cross_reference: NDFRT:N0000008100

Guanosine 5'-O-(3-Thiotriphosphate)
type: Class
subclass of: Thionucleotides
MCID: MC00041106
PMOID: PMO:00017506
Subclass_of: Thionucleotides
Synonym: GTP gamma S
Synonym: GTPgammaS
Synonym: GUANOSINE 5 3 O THIO TRIPHOSPHATE
Synonym: GUANOSINE 5 GAMMA S TRIPHOSPHATE
Synonym: GUANOSINE 5 O 3 THIOTRIPHOSPHATE
Synonym: GUANOSINEGAMMASTRIPHOSPHATE 05
Synonym: GUANOSINETHIOTRIPHOSPHATE O0503
Synonym: Guanosine 5'-(3-O-Thio)Triphosphate
Synonym: Guanosine 5'-(gamma-S)Triphosphate
Synonym: Guanosine 5'-(trihydrogen diphosphate), P'-anhydride with phosphorothioic acid
Tree Number: T6.11.4.8.1
Tree Number: T6.2.32.21.1
database_cross_reference: MSH:D016244
database_cross_reference: NDFRT:N0000170852

Thiophenes
type: Class
subclass of: Sulfur Compounds
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00012746
PMOID: PMO:00017507
Subclass_of: Heterocyclic Compounds, 1-Ring
Subclass_of: Sulfur Compounds
Synonym: Thiophenes [Chemical/Ingredient]
Tree Number: T6.2.32.22
Tree Number: T6.3.5.25
database_cross_reference: LCH_NW:sh85134885
database_cross_reference: MSH:D013876
database_cross_reference: NDFRT:N0000008103

Duloxetine Hydrochloride
type: Class
subclass of: Thiophenes
MCID: MC00521086
PMOID: PMO:00017508
Subclass_of: Thiophenes
Synonym: DULOXETINE HYDROCHLORIDE
Synonym: DULoxetine Hydrochloride
Synonym: DULoxetine hydrochloride
Synonym: Duloxetine HCl
Synonym: Duloxetine Hydrochloride [Chemical/Ingredient]
Synonym: Duloxetine hydrochloride
Synonym: Duloxetine hydrochloride (substance)
Synonym: HCl, Duloxetine
Synonym: Hydrochloride, Duloxetine
Synonym: duloxetine HCl
Tree Number: T6.2.32.22.1
Tree Number: T6.3.5.25.1
database_cross_reference: DRUGBANK:DB00476
database_cross_reference: MEDCIN:300049
database_cross_reference: MMSL:18760
database_cross_reference: MMSL:208014
database_cross_reference: MSH:D000068736
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9044SC542W
database_cross_reference: NCI:C65496
database_cross_reference: NCI_FDA:9044SC542W
database_cross_reference: NCI_NCI-GLOSS:CDR0000589399
database_cross_reference: NDDF:008707
database_cross_reference: NDFRT:N0000191950
database_cross_reference: RXNORM:476250
database_cross_reference: SNOMEDCT_US:426892003
database_cross_reference: USPMG:MTHU000050

Prasugrel Hydrochloride
type: Class
subclass of: Thiophenes
subclass of: Piperazines
MCID: MC00739096
PMOID: PMO:00017509
Subclass_of: Piperazines
Subclass_of: Thiophenes
Synonym: HCl, Prasugrel
Synonym: Hydrochloride, Prasugrel
Synonym: PRASUGREL HYDROCHLORIDE
Synonym: Prasugrel HCl
Synonym: Prasugrel Hydrochloride [Chemical/Ingredient]
Synonym: Prasugrel hydrochloride
Synonym: prasugrel HCl
Synonym: prasugrel hydrochloride
Tree Number: T6.2.32.22.2
Tree Number: T6.3.5.15.3
Tree Number: T6.3.5.25.2
database_cross_reference: MSH:D000068799
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:G89JQ59I13
database_cross_reference: NCI:C81571
database_cross_reference: NCI_FDA:G89JQ59I13
database_cross_reference: NDDF:012995
database_cross_reference: NDFRT:N0000179827
database_cross_reference: NDFRT:N0000191972
database_cross_reference: RXNORM:847020
database_cross_reference: VANDF:4029068

Canagliflozin
type: Class
subclass of: Thiophenes
subclass of: PMO:00020974
MCID: MC00810518
PMOID: PMO:00017510
Subclass_of: Glucosides
Subclass_of: Thiophenes
Synonym: CANAGLIFLOZIN
Synonym: Canagliflozin (product)
Synonym: Canagliflozin (substance)
Synonym: Canagliflozin [Chemical/Ingredient]
Synonym: antidiabetics canagliflozin
Synonym: canagliflozin
Synonym: canagliflozin (medication)
Tree Number: T6.2.32.22.3
Tree Number: T6.3.5.25.3
Tree Number: T6.8.6.7.1
database_cross_reference: ATC:A10BK02
database_cross_reference: DRUGBANK:DB08907
database_cross_reference: MEDCIN:343198
database_cross_reference: MMSL:d08080
database_cross_reference: MSH:D000068896
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:0SAC974Z85
database_cross_reference: NCI:C91018
database_cross_reference: NCI_FDA:0SAC974Z85
database_cross_reference: NDDF:014959
database_cross_reference: NDFRT:N0000186951
database_cross_reference: NDFRT:N0000191980
database_cross_reference: RXNORM:1373458
database_cross_reference: SNOMEDCT_US:703676004
database_cross_reference: SNOMEDCT_US:703681008
database_cross_reference: USPMG:MTHU002762
database_cross_reference: VANDF:4032289

Rivaroxaban
type: Class
subclass of: Thiophenes
MCID: MC00587898
PMOID: PMO:00017511
Subclass_of: Thiophenes
Synonym: 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)- 1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
Synonym: 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
Synonym: RIVAROXABAN
Synonym: Rivaroxaban (medication)
Synonym: Rivaroxaban (product)
Synonym: Rivaroxaban (substance)
Synonym: Rivaroxaban [Chemical/Ingredient]
Synonym: anticoagulants rivaroxaban
Synonym: rivaroxaban
Tree Number: T6.2.32.22.4
Tree Number: T6.3.5.25.4
database_cross_reference: ATC:B01AF01
database_cross_reference: DRUGBANK:DB06228
database_cross_reference: LNC:LP135650-2
database_cross_reference: LNC:MTHU042952
database_cross_reference: MEDCIN:309421
database_cross_reference: MMSL:26019
database_cross_reference: MMSL:d07356
database_cross_reference: MSH:D000069552
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9NDF7JZ4M3
database_cross_reference: NCI:C77995
database_cross_reference: NCI_FDA:9NDF7JZ4M3
database_cross_reference: NDDF:012873
database_cross_reference: NDFRT:N0000182971
database_cross_reference: NDFRT:N0000191960
database_cross_reference: RXNORM:1114195
database_cross_reference: SNOMEDCT_US:442031002
database_cross_reference: SNOMEDCT_US:442539005
database_cross_reference: USPMG:MTHU002791
database_cross_reference: VANDF:4030906

Carticaine
type: Class
subclass of: Thiophenes
MCID: MC00558403
PMOID: PMO:00017512
Subclass_of: Thiophenes
Synonym: 2-Thiophenecarboxylic acid, 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester
Synonym: 4% Astracaine Dental With Epinephrine 1:200,000 (0.005mg/ml)
Synonym: 4% Astracaine Dental With Epinephrine Forte 1:100,000 (0.01mg/ml)
Synonym: ARTICAINE
Synonym: Articain
Synonym: Articaine
Synonym: Articaine (substance)
Synonym: Articaine HCl and Epinephrine
Synonym: Carticain
Synonym: Carticaine [Chemical/Ingredient]
Tree Number: T6.2.32.22.5
Tree Number: T6.3.5.25.5
database_cross_reference: ATC:N01BB08
database_cross_reference: CHV:0000002495
database_cross_reference: DRUGBANK:DB00668
database_cross_reference: DRUGBANK:DB09009
database_cross_reference: LNC:LP96208-1
database_cross_reference: MMSL:d04536
database_cross_reference: MSH:D002355
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:D3SQ406G9X
database_cross_reference: NCI:C72173
database_cross_reference: NCI_FDA:D3SQ406G9X
database_cross_reference: NDDF:003799
database_cross_reference: NDDF:005096
database_cross_reference: NDFRT:N0000010070
database_cross_reference: NDFRT:N0000148787
database_cross_reference: RXNORM:592464
database_cross_reference: SNOMEDCT_US:410851000
database_cross_reference: SNOMEDCT_US:703107005
database_cross_reference: VANDF:4021368

Ketotifen
type: Class
subclass of: Thiophenes
subclass of: Piperidines
MCID: MC00007237
PMOID: PMO:00017513
Subclass_of: Piperidines
Subclass_of: Thiophenes
Synonym: 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-
Synonym: 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one
Synonym: Allergy Eye Drops
Synonym: Allergy Eye Original Prescription Strength
Synonym: Antihistamine Eye
Synonym: Apo-ketotifen - Syr 1mg/5ml
Synonym: Care One Allergy Eye
Synonym: Care One Eye Itch Relief
Synonym: Equaline Eye Itch Relief
Synonym: Equate Itchy Eye
Tree Number: T6.2.32.22.6
Tree Number: T6.3.5.16.13
Tree Number: T6.3.5.25.6
database_cross_reference: ATC:R06AX17
database_cross_reference: ATC:S01GX08
database_cross_reference: CHV:0000007083
database_cross_reference: DRUGBANK:DB00920
database_cross_reference: LCH:U002578
database_cross_reference: LCH_NW:sh85072098
database_cross_reference: MSH:D007665
database_cross_reference: MTHSPL:X49220T18G
database_cross_reference: NCI:C61799
database_cross_reference: NCI_FDA:X49220T18G
database_cross_reference: NDDF:003742
database_cross_reference: NDFRT:N0000007350
database_cross_reference: NDFRT:N0000148619
database_cross_reference: RCD:c73..
database_cross_reference: RCD:c8b..
database_cross_reference: RCD:x02LJ
database_cross_reference: RXNORM:6146
database_cross_reference: SNOMEDCT_US:320662004
database_cross_reference: SNOMEDCT_US:320746003
database_cross_reference: SNOMEDCT_US:354038002
database_cross_reference: SNOMEDCT_US:372642003
database_cross_reference: SNOMEDCT_US:395297001
database_cross_reference: VANDF:4021170

Morantel
type: Class
subclass of: Thiophenes
subclass of: Pyrimidines
MCID: MC00008408
PMOID: PMO:00017514
Subclass_of: Pyrimidines
Subclass_of: Thiophenes
Synonym: MORANTEL
Synonym: Morantel [Chemical/Ingredient]
Synonym: Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(3-methyl-2-thienyl)ethenyl)-, (E)-
Tree Number: T6.2.32.22.8
Tree Number: T6.3.5.21.12
Tree Number: T6.3.5.25.7
database_cross_reference: MSH:D009015
database_cross_reference: MTHSPL:7NJ031HAX5
database_cross_reference: NCI:C75221
database_cross_reference: NCI_FDA:7NJ031HAX5
database_cross_reference: NDFRT:N0000167196
database_cross_reference: RXNORM:1368900

Pizotyline
type: Class
subclass of: Thiophenes
MCID: MC00010270
PMOID: PMO:00017515
Subclass_of: Thiophenes
Synonym: 4-(9,10-Dihydro-4H-Benzo(4,5)Cyclohepta(1,2-B)Thien-4-ylidene)-1-Methylpiperidine
Synonym: PIZOTYLINE
Synonym: Piperidine, 4-(9,10-Dihydro-4H-Benzo(4,5)Cyclohepta(1,2-b)Thien-4-Ylidene)-1-Methyl-
Synonym: Piperidine, 4-(9,10-dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thien-4-ylidene)-1-methyl-
Synonym: Pizotifen
Synonym: Pizotifen (product)
Synonym: Pizotifen (substance)
Synonym: Pizotifen product
Synonym: Pizotifen product (substance)
Synonym: Pizotyline [Chemical/Ingredient]
Tree Number: T6.2.32.22.9
Tree Number: T6.3.5.25.8
database_cross_reference: ATC:N02CX01
database_cross_reference: CHV:0000009774
database_cross_reference: DRUGBANK:DB06153
database_cross_reference: MSH:D010918
database_cross_reference: NCI:C87214
database_cross_reference: NCI_FDA:0BY8440V3N
database_cross_reference: NDDF:003497
database_cross_reference: NDFRT:N0000167169
database_cross_reference: RCD:x01E7
database_cross_reference: RXNORM:8373
database_cross_reference: SNOMEDCT_US:349963006
database_cross_reference: SNOMEDCT_US:363567001
database_cross_reference: SNOMEDCT_US:395834002

Pyrantel
type: Class
subclass of: Thiophenes
subclass of: Pyrimidines
MCID: MC00010982
PMOID: PMO:00017516
Subclass_of: Pyrimidines
Subclass_of: Thiophenes
Synonym: CVS Pinworm Treatment
Synonym: Combantrin Oral Suspension 50mg/ml
Synonym: Combantrin Tab 125mg
Synonym: Jaa Pyral 125 Tablet 125mg
Synonym: Jaa Pyral 35 Tablet 35mg
Synonym: Jaa Pyral P Oral Paste - 125mg/g
Synonym: Jaa Pyral S Suspension 50mg/76
Synonym: Jamp-pyrantel Pamoate
Synonym: Jamp-pyrantel Pamoate Suspension
Synonym: PYRANTEL
Tree Number: T6.2.32.22.10
Tree Number: T6.3.5.21.15
Tree Number: T6.3.5.25.9
database_cross_reference: ATC:P02CC01
database_cross_reference: CHV:0000010444
database_cross_reference: DRUGBANK:DB11156
database_cross_reference: MMSL:d01123
database_cross_reference: MSH:D011715
database_cross_reference: MTHSPL:4QIH0N49E7
database_cross_reference: NCI:C75231
database_cross_reference: NCI_FDA:4QIH0N49E7
database_cross_reference: NDDF:002986
database_cross_reference: NDFRT:N0000007559
database_cross_reference: NDFRT:N0000148005
database_cross_reference: RCD:er1..
database_cross_reference: RXNORM:8984
database_cross_reference: SNMI:C-56A60
database_cross_reference: SNOMEDCT_US:36068003
database_cross_reference: SNOMEDCT_US:387193008
database_cross_reference: VANDF:4019920

Thienopyridines
type: Class
subclass of: Thiophenes
subclass of: Heterocyclic Compounds, 2-Ring
subclass of: Pyridines
MCID: MC00369191
PMOID: PMO:00017519
Subclass_of: Heterocyclic Compounds, 2-Ring
Subclass_of: Pyridines
Subclass_of: Thiophenes
Synonym: thienopyridine
Synonym: thienopyridines
Tree Number: T6.2.32.22.14
Tree Number: T6.3.1.1.30
Tree Number: T6.3.5.20.34
Tree Number: T6.3.5.25.13
database_cross_reference: CHV:0000054785
database_cross_reference: MSH:C446540
database_cross_reference: MTH:NOCODE

Thiourea
type: Class
subclass of: Sulfur Compounds
subclass of: Urea
MCID: MC00012763
PMOID: PMO:00017521
Subclass_of: Sulfur Compounds
Subclass_of: Urea
Synonym: 2-Thiourea
Synonym: Isothiourea
Synonym: Pseudothiourea
Synonym: Sulfourea
Synonym: THIOUREA
Synonym: THU
Synonym: Thiocarbamide
Synonym: Thiourea (product)
Synonym: Thiourea (substance)
Synonym: Thiourea [Chemical/Ingredient]
Tree Number: T6.2.32.24
Tree Number: T6.2.34.10
database_cross_reference: CHV:0000012198
database_cross_reference: CSP:2913-2642
database_cross_reference: LCH_NW:sh88002082
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D013890
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C44455
database_cross_reference: NCI_FDA:GYV9AM2QAG
database_cross_reference: NDFRT:N0000166458
database_cross_reference: NDFRT:N0000171813
database_cross_reference: RCD:X79JQ
database_cross_reference: SNM:E-5867
database_cross_reference: SNMI:C-22043
database_cross_reference: SNOMEDCT_US:411399003
database_cross_reference: SNOMEDCT_US:47826006
database_cross_reference: VANDF:4025288

beta-Aminoethyl Isothiourea
type: Class
subclass of: Thiourea
MCID: MC00170205
PMOID: PMO:00017522
Subclass_of: Thiourea
Synonym: Isothiourea, (2-Aminoethyl)
Synonym: Isothiourea, beta-Aminoethyl
Synonym: S-(2-Aminoethyl)isothiourea
Synonym: beta Aminoethyl Isothiourea
Synonym: beta-Aminoethyl Isothiourea [Chemical/Ingredient]
Tree Number: T6.2.32.24.1
Tree Number: T6.2.34.10.1
database_cross_reference: MSH:D000338
database_cross_reference: NDFRT:N0000166462

Burimamide
type: Class
subclass of: Thiourea
MCID: MC00002027
PMOID: PMO:00017523
Subclass_of: Thiourea
Synonym: Burimamide [Chemical/Ingredient]
Synonym: Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl-
Tree Number: T6.2.32.24.2
Tree Number: T6.2.34.10.2
database_cross_reference: MSH:D002049
database_cross_reference: NDFRT:N0000166461

Guanylthiourea
type: Class
subclass of: Thiourea
MCID: MC00005884
PMOID: PMO:00017524
Subclass_of: Thiourea
Synonym: Guanylthiourea [Chemical/Ingredient]
Synonym: Guthimine
Synonym: Guthymine
Synonym: Gutimin
Synonym: Gutimine
Synonym: Thiourea, (aminoiminomethyl)-
Tree Number: T6.2.32.24.3
Tree Number: T6.2.34.10.4
database_cross_reference: MSH:D006164
database_cross_reference: NDFRT:N0000166459

Isothiuronium
type: Class
subclass of: Thiourea
MCID: MC00007116
PMOID: PMO:00017525
Subclass_of: Thiourea
Synonym: Carbamimidothioic acid, 10-undecenyl ester, monohydriodide
Synonym: Isothiouronium
Synonym: Isothiuronium [Chemical/Ingredient]
Tree Number: T6.2.32.24.4
Tree Number: T6.2.34.10.5
database_cross_reference: MSH:D007550
database_cross_reference: NDFRT:N0000166466

Methallibure
type: Class
subclass of: Thiourea
MCID: MC00008159
PMOID: PMO:00017526
Subclass_of: Thiourea
Synonym: 1,2-Hydrazinedicarbothioamide, N-methyl-N'-(1-methyl-2-propenyl)-
Synonym: Metallibur
Synonym: Metallibure
Synonym: Methallibure [Chemical/Ingredient]
Tree Number: T6.2.32.24.5
Tree Number: T6.2.34.10.6
database_cross_reference: MSH:D008693
database_cross_reference: NDFRT:N0000166463

Metiamide
type: Class
subclass of: Thiourea
MCID: MC00008255
PMOID: PMO:00017527
Subclass_of: Thiourea
Synonym: METIAMIDE
Synonym: Methiamide
Synonym: Metiamida
Synonym: Metiamide [Chemical/Ingredient]
Synonym: Metiamidum
Synonym: Thiourea, N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-
Tree Number: T6.2.32.24.6
Tree Number: T6.2.34.10.7
database_cross_reference: DRUGBANK:DB08805
database_cross_reference: MSH:D008785
database_cross_reference: NCI:C90862
database_cross_reference: NCI_FDA:3K7670861M
database_cross_reference: NDFRT:N0000166467

Noxythiolin
type: Class
subclass of: Thiourea
MCID: MC00009032
PMOID: PMO:00017528
Subclass_of: Thiourea
Synonym: N-Methyl-N''-(hydroxymethyl)thiourea
Synonym: NOXYTIOLIN
Synonym: Noxitiolin
Synonym: Noxitiolinum
Synonym: Noxythiolin (product)
Synonym: Noxythiolin (substance)
Synonym: Noxythiolin [Chemical/Ingredient]
Synonym: Noxytiolin
Synonym: Thiourea, N-(hydroxymethyl)-N'-methyl-
Synonym: noxythiolin
Tree Number: T6.2.32.24.7
Tree Number: T6.2.34.10.8
database_cross_reference: ATC:B05CA07
database_cross_reference: MSH:D009677
database_cross_reference: NCI:C66248
database_cross_reference: NCI_FDA:4DN3AF1FU6
database_cross_reference: NDDF:003749
database_cross_reference: NDFRT:N0000166468
database_cross_reference: RCD:eg5..
database_cross_reference: RXNORM:7543
database_cross_reference: SNOMEDCT_US:324586003
database_cross_reference: SNOMEDCT_US:395812004

Phenylthiourea
type: Class
subclass of: Thiourea
MCID: MC00010062
PMOID: PMO:00017529
Subclass_of: Thiourea
Synonym: Phenylthiocarbamide
Synonym: Phenylthiourea [Chemical/Ingredient]
Synonym: Thiourea, phenyl-
Synonym: phenylthiocarbamide
Tree Number: T6.2.32.24.8
Tree Number: T6.2.34.10.9
database_cross_reference: CHV:0000009621
database_cross_reference: MSH:D010670
database_cross_reference: NDFRT:N0000166464

Dimaprit
type: Class
subclass of: Thiourea
MCID: MC00025102
PMOID: PMO:00017531
Subclass_of: Thiourea
Synonym: Carbamimidothioic acid, 3-(dimethylamino)propyl ester
Synonym: Dimaprit [Chemical/Ingredient]
Tree Number: T6.2.32.24.9
Tree Number: T6.2.34.10.10
database_cross_reference: MSH:D017259
database_cross_reference: NDFRT:N0000166460

Thioxanthenes
type: Class
subclass of: Sulfur Compounds
MCID: MC00012766
PMOID: PMO:00017532
Subclass_of: Sulfur Compounds
Synonym: Thioxanthene
Synonym: Thioxanthene (product)
Synonym: Thioxanthene (substance)
Synonym: Thioxanthenes [Chemical/Ingredient]
Synonym: thioxanthene
Synonym: thioxanthenes
Tree Number: T6.2.32.25
database_cross_reference: AOD:0000020962
database_cross_reference: CHV:0000012199
database_cross_reference: LCH:U004658
database_cross_reference: LCH_NW:sh85134891
database_cross_reference: MSH:D013892
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008107
database_cross_reference: RCD:x00BI
database_cross_reference: SNOMEDCT_US:123683006

Chlorprothixene
type: Class
subclass of: Thioxanthenes
MCID: MC00002689
PMOID: PMO:00017533
Subclass_of: Thioxanthenes
Synonym: 1-Propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (Z)-
Synonym: Alpha-Chlorprothixene
Synonym: CHLORPROTHIXENE
Synonym: Chlorprothixen
Synonym: Chlorprothixene (product)
Synonym: Chlorprothixene (substance)
Synonym: Chlorprothixene [Chemical/Ingredient]
Synonym: Chlorprothixine
Synonym: Chlorprotixen
Synonym: Chlorprotixene
Tree Number: T6.2.32.25.1
database_cross_reference: ATC:N05AF03
database_cross_reference: CHV:0000002844
database_cross_reference: DRUGBANK:DB01239
database_cross_reference: LNC:LP16076-9
database_cross_reference: LNC:MTHU015644
database_cross_reference: MEDCIN:41366
database_cross_reference: MSH:D002749
database_cross_reference: NCI:C65325
database_cross_reference: NCI_FDA:9S7OD60EWP
database_cross_reference: NDDF:001516
database_cross_reference: NDFRT:N0000006953
database_cross_reference: NDFRT:N0000146149
database_cross_reference: PSY:09000
database_cross_reference: RCD:d43..
database_cross_reference: RXNORM:2406
database_cross_reference: SNM:E-7912
database_cross_reference: SNMI:C-63010
database_cross_reference: SNOMEDCT_US:387317000
database_cross_reference: SNOMEDCT_US:57002000
database_cross_reference: VANDF:4017788

Clopenthixol
type: Class
subclass of: Thioxanthenes
MCID: MC00002974
PMOID: PMO:00017534
Subclass_of: Thioxanthenes
Synonym: 1-Piperazineethanol, 4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)-
Synonym: CLOPENTHIXOL, TRANS
Synonym: Clopenthixol (product)
Synonym: Clopenthixol (substance)
Synonym: Clopenthixol [Chemical/Ingredient]
Synonym: Clopenthixol, Trans
Synonym: clopenthixol
Tree Number: T6.2.32.25.2
database_cross_reference: ATC:N05AF02
database_cross_reference: LCH_NW:sh97004598
database_cross_reference: LNC:LP16087-6
database_cross_reference: LNC:MTHU016327
database_cross_reference: MSH:D003006
database_cross_reference: NCI:C81091
database_cross_reference: NCI_FDA:FLE878A8ZI
database_cross_reference: NDFRT:N0000167266
database_cross_reference: SNMI:C-63030
database_cross_reference: SNOMEDCT_US:387566002
database_cross_reference: SNOMEDCT_US:427940003
database_cross_reference: SNOMEDCT_US:96219008

Flupenthixol
type: Class
subclass of: Thioxanthenes
subclass of: Piperazines
MCID: MC00005210
PMOID: PMO:00017535
Subclass_of: Piperazines
Subclass_of: Thioxanthenes
Synonym: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-
Synonym: FLUPENTIXOL
Synonym: Fluanxol 0.5mg - Tab
Synonym: Fluanxol 3mg - Tab
Synonym: Fluanxol Depot 10%- Liq Im 100mg/ml
Synonym: Fluanxol Depot 2% -liq Im 20mg/ml
Synonym: Fluanxol Depot Inj 100mg/ml
Synonym: Fluanxol Depot Inj 20mg/ml
Synonym: Fluanxol Tab 0.5mg
Synonym: Fluanxol Tab 3mg
Tree Number: T6.2.32.25.3
Tree Number: T6.3.5.15.15
database_cross_reference: AOD:0000020963
database_cross_reference: AOD:0000029108
database_cross_reference: ATC:N05AF01
database_cross_reference: CHV:0000005132
database_cross_reference: DRUGBANK:DB00875
database_cross_reference: LNC:LP16151-0
database_cross_reference: LNC:MTHU015994
database_cross_reference: MEDCIN:340065
database_cross_reference: MSH:D005475
database_cross_reference: NCI:C73315
database_cross_reference: NCI_FDA:21HMQ851IS
database_cross_reference: NDDF:003477
database_cross_reference: NDFRT:N0000167265
database_cross_reference: RCD:d45..
database_cross_reference: RCD:da1..
database_cross_reference: RCD:x02LQ
database_cross_reference: RXNORM:4495
database_cross_reference: SNMI:C-63040
database_cross_reference: SNOMEDCT_US:321405002
database_cross_reference: SNOMEDCT_US:321932004
database_cross_reference: SNOMEDCT_US:387567006
database_cross_reference: SNOMEDCT_US:96220002

Hycanthone
type: Class
subclass of: Thioxanthenes
MCID: MC00006433
PMOID: PMO:00017536
Subclass_of: Thioxanthenes
Synonym: 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-
Synonym: HYC
Synonym: HYCANTHONE
Synonym: Hycanthone [Chemical/Ingredient]
Synonym: hycanthone
Tree Number: T6.2.32.25.4
database_cross_reference: MSH:D006826
database_cross_reference: NCI:C550
database_cross_reference: NCI_DTP:NSC0134434
database_cross_reference: NCI_FDA:2BXX5EVN2A
database_cross_reference: NDFRT:N0000167267
database_cross_reference: PDQ:CDR0000039477

Lucanthone
type: Class
subclass of: Thioxanthenes
MCID: MC00007689
PMOID: PMO:00017537
Subclass_of: Thioxanthenes
Synonym: 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one
Synonym: 1-diethylaminoethylethylamino-4-methyl-thioxanthenone
Synonym: 1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one
Synonym: 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl-
Synonym: LUCANTHONE
Synonym: Lucanthone (substance)
Synonym: Lucanthone [Chemical/Ingredient]
Synonym: Lucanthonum
Synonym: Lucantona
Synonym: lucanthone
Tree Number: T6.2.32.25.5
database_cross_reference: CSP:2913-8261
database_cross_reference: DRUGBANK:DB04967
database_cross_reference: MSH:D008154
database_cross_reference: NCI:C83925
database_cross_reference: NCI_FDA:FC6D57000M
database_cross_reference: NDDF:004876
database_cross_reference: NDFRT:N0000167264
database_cross_reference: SNM:E-7433
database_cross_reference: SNMI:C-56720
database_cross_reference: SNOMEDCT_US:68310009

Thiothixene
type: Class
subclass of: Thioxanthenes
MCID: MC00012760
PMOID: PMO:00017538
Subclass_of: Thioxanthenes
Synonym: (e)-thiothixene
Synonym: 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-
Synonym: N,N-Dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9H-thioxanthene-2-sulphonamide
Synonym: Navan
Synonym: Navane Cap 2mg
Synonym: Navane Cap 5mg
Synonym: Navaron
Synonym: Orbinamon
Synonym: THIOTHIXENE
Synonym: Thiothixene (product)
Tree Number: T6.2.32.25.6
database_cross_reference: AOD:0000020953
database_cross_reference: ATC:N05AF04
database_cross_reference: CHV:0000012196
database_cross_reference: CSP:2332-0723
database_cross_reference: DRUGBANK:DB01623
database_cross_reference: LCH:U004657
database_cross_reference: LCH_NW:sh85134890
database_cross_reference: LNC:LP17169-1
database_cross_reference: LNC:MTHU003229
database_cross_reference: MEDCIN:41378
database_cross_reference: MMSL:2137
database_cross_reference: MMSL:5574
database_cross_reference: MMSL:d00391
database_cross_reference: MSH:D013888
database_cross_reference: MTHSPL:7318FJ13YJ
database_cross_reference: NCI:C47752
database_cross_reference: NCI_FDA:7318FJ13YJ
database_cross_reference: NDDF:001529
database_cross_reference: NDFRT:N0000007308
database_cross_reference: NDFRT:N0000148032
database_cross_reference: PSY:52910
database_cross_reference: RXNORM:10510
database_cross_reference: SNM:E-7949
database_cross_reference: SNMI:C-63020
database_cross_reference: SNOMEDCT_US:372804006
database_cross_reference: SNOMEDCT_US:62529008
database_cross_reference: USPMG:MTHU000613
database_cross_reference: VANDF:4019947

Isothiocyanates
type: Class
subclass of: Sulfur Compounds
subclass of: Isocyanates
MCID: MC00051721
PMOID: PMO:00017539
Subclass_of: Isocyanates
Subclass_of: Sulfur Compounds
Synonym: Isothiocyanate
Synonym: isothiocyanate
Tree Number: T6.2.32.26
Tree Number: T6.2.37.2
database_cross_reference: CHV:0000016326
database_cross_reference: MSH:C037152
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45711
database_cross_reference: NCI_CRCH:C45711
database_cross_reference: NCI_DCP:09213

Thiazides
type: Class
subclass of: Sulfur Compounds
MCID: MC00004086
PMOID: PMO:00017540
Subclass_of: Sulfur Compounds
Synonym: 722 THIAZIDE DIURETICS
Synonym: Benzothiadiazine Diuretics
Synonym: Diuretics, Benzothiadiazine
Synonym: Diuretics, Thiazide
Synonym: THIAZIDE DIURETIC
Synonym: THIAZIDE DIURETICS
Synonym: THIAZIDES/RELATED DIURETICS
Synonym: Thiazide Diuretic
Synonym: Thiazide Diuretics
Synonym: Thiazide diuretic
Tree Number: T6.2.32.28
database_cross_reference: CCPSS:0012253
database_cross_reference: CHV:0000004049
database_cross_reference: MEDCIN:44713
database_cross_reference: MSH:D049993
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C49185
database_cross_reference: NDFRT:N0000029126
database_cross_reference: RCD:b2...
database_cross_reference: RCD:x01Qt
database_cross_reference: SNMI:C-72200
database_cross_reference: SNOMEDCT_US:350616005
database_cross_reference: SNOMEDCT_US:371342005
database_cross_reference: SNOMEDCT_US:371343000
database_cross_reference: SNOMEDCT_US:372747003
database_cross_reference: SNOMEDCT_US:45518007
database_cross_reference: USPMG:MTHU002946
database_cross_reference: VANDF:4021573

Triazenes
type: Class
subclass of: Organic Chemicals
MCID: MC00013047
PMOID: PMO:00017541
Subclass_of: Organic Chemicals
Synonym: Triazene Compound
Synonym: Triazene Compounds
Synonym: Triazenes [Chemical/Ingredient]
Tree Number: T6.2.33
database_cross_reference: LCH_NW:sh90004537
database_cross_reference: MSH:D014226
database_cross_reference: NCI:C902
database_cross_reference: NDFRT:N0000007557

Dacarbazine
type: Class
subclass of: Triazenes
MCID: MC00003534
PMOID: PMO:00017542
Subclass_of: Triazenes
Synonym: 1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-
Synonym: 1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-
Synonym: 4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide
Synonym: 4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide
Synonym: 4-(Dimethyltriazeno)imidazole-5-carboxamide
Synonym: 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide
Synonym: 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
Synonym: 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide
Synonym: 5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide
Synonym: 5-(Dimethyltriazeno)imidazole-4-carboxamide
Tree Number: T6.2.33.1
database_cross_reference: ATC:L01AX04
database_cross_reference: CHV:0000003597
database_cross_reference: CSP:1548-5525
database_cross_reference: DRUGBANK:DB00851
database_cross_reference: MEDCIN:40503
database_cross_reference: MMSL:31748
database_cross_reference: MMSL:4528
database_cross_reference: MMSL:d00202
database_cross_reference: MSH:D003606
database_cross_reference: MTH:U001844
database_cross_reference: MTHSPL:7GR28W0FJI
database_cross_reference: NCI:C411
database_cross_reference: NCI_DTP:NSC0045388
database_cross_reference: NCI_FDA:7GR28W0FJI
database_cross_reference: NCI_NCI-GLOSS:CDR0000045260
database_cross_reference: NDDF:002671
database_cross_reference: NDFRT:N0000006842
database_cross_reference: NDFRT:N0000146713
database_cross_reference: PDQ:CDR0000039768
database_cross_reference: RCD:h54..
database_cross_reference: RCD:x02ab
database_cross_reference: RXNORM:3098
database_cross_reference: SNM:E-8369
database_cross_reference: SNM:E-8376
database_cross_reference: SNMI:C-78090
database_cross_reference: SNOMEDCT_US:387441003
database_cross_reference: SNOMEDCT_US:77750008
database_cross_reference: VANDF:4018386

Urea
type: Class
subclass of: Organic Chemicals
MCID: MC00013338
PMOID: PMO:00017543
Subclass_of: Organic Chemicals
Synonym: Calmurid Crm
Synonym: Calmurid HC Crm
Synonym: Carb-O-Philic
Synonym: Carbamex 330mgms
Synonym: Carbamide
Synonym: Carbonyldiamide
Synonym: Dr. Scholl's Cracked Heel Relief Cream
Synonym: Flexitol Heel Balm
Synonym: Gehwol FUSSKRAFT Callus Softener
Synonym: Gehwol med Callus
Tree Number: T6.2.34
database_cross_reference: AOD:0000001906
database_cross_reference: ATC:B05BC02
database_cross_reference: ATC:D02AE01
database_cross_reference: CHV:0000012752
database_cross_reference: CSP:0113-3157
database_cross_reference: DRUGBANK:DB03904
database_cross_reference: LCH:U004852
database_cross_reference: LCH_NW:sh85141359
database_cross_reference: LNC:LP14288-2
database_cross_reference: LNC:LP32647-7
database_cross_reference: LNC:LP69843-8
database_cross_reference: LNC:MTHU009413
database_cross_reference: MEDCIN:258293
database_cross_reference: MEDCIN:40753
database_cross_reference: MMSL:5656
database_cross_reference: MMSL:9476
database_cross_reference: MMSL:d04207
database_cross_reference: MSH:D014508
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:8W8T17847W
database_cross_reference: NCI:C29531
database_cross_reference: NCI_DCP:05047
database_cross_reference: NCI_DTP:NSC0034375
database_cross_reference: NCI_FDA:8W8T17847W
database_cross_reference: NCI_NCI-GLOSS:CDR0000471785
database_cross_reference: NCI_NCI-GLOSS:CDR0000572226
database_cross_reference: NDDF:002015
database_cross_reference: NDDF:002273
database_cross_reference: NDFRT:N0000006999
database_cross_reference: NDFRT:N0000146756
database_cross_reference: PDQ:CDR0000040286
database_cross_reference: RCD:XM0l7
database_cross_reference: RCD:b62..
database_cross_reference: RXNORM:11002
database_cross_reference: SNM:E-8886
database_cross_reference: SNM:F-10630
database_cross_reference: SNMI:C-72060
database_cross_reference: SNOMEDCT_US:144004004
database_cross_reference: SNOMEDCT_US:166710001
database_cross_reference: SNOMEDCT_US:16858004
database_cross_reference: SNOMEDCT_US:273947000
database_cross_reference: SNOMEDCT_US:387092000
database_cross_reference: VANDF:4018430

Allantoin
type: Class
subclass of: Urea
MCID: MC00000572
PMOID: PMO:00017544
Subclass_of: Urea
Synonym: 12 Hour Healing
Synonym: 12 Hour Miracle
Synonym: 28 Remedy Aqua Brightening Peeling
Synonym: 3M Nexcare Cold Sore Treatment
Synonym: 3ce Fixer and Mascara Black
Synonym: 3ce Fixer and Mascara Brown
Synonym: 4Jointz
Synonym: 5-ureidohydantoin
Synonym: A.H.c Cotton 100 Mask Multi Peptide
Synonym: A.H.c Cotton 100 Mask Skin Ceramide
Tree Number: T6.2.34.1
database_cross_reference: CHV:0000000908
database_cross_reference: CSP:1548-6765
database_cross_reference: DRUGBANK:DB11100
database_cross_reference: LCH:U000150
database_cross_reference: LCH_NW:sh85003625
database_cross_reference: MEDCIN:198770
database_cross_reference: MEDCIN:40743
database_cross_reference: MMSL:4149
database_cross_reference: MMSL:72840
database_cross_reference: MSH:D000481
database_cross_reference: MTHSPL:344S277G0Z
database_cross_reference: NCI:C74277
database_cross_reference: NCI_FDA:344S277G0Z
database_cross_reference: NDDF:002009
database_cross_reference: NDFRT:N0000005787
database_cross_reference: NDFRT:N0000146926
database_cross_reference: RXNORM:508
database_cross_reference: SNOMEDCT_US:395933009
database_cross_reference: SNOMEDCT_US:404834008
database_cross_reference: VANDF:4018613

Biureas
type: Class
subclass of: Urea
MCID: MC00001780
PMOID: PMO:00017545
Subclass_of: Urea
Synonym: Biureas [Chemical/Ingredient]
Tree Number: T6.2.34.2
database_cross_reference: MSH:D001736
database_cross_reference: NDFRT:N0000166304

Biuret
type: Class
subclass of: Urea
MCID: MC00001781
PMOID: PMO:00017546
Subclass_of: Urea
Synonym: Allophanamide
Synonym: Biuret [Chemical/Ingredient]
Synonym: Carbamylurea
Synonym: Imidodicarbonic diamide
Synonym: biuret
Tree Number: T6.2.34.3
database_cross_reference: CHV:0000001943
database_cross_reference: MSH:D001737
database_cross_reference: NDFRT:N0000166299

Bromisovalum
type: Class
subclass of: Urea
MCID: MC00001957
PMOID: PMO:00017547
Subclass_of: Urea
Synonym: (alpha-Bromoisovaleryl)urea
Synonym: 2-Bromo-3-methylbutyrylurea
Synonym: BROMISOVAL
Synonym: Bromisoval
Synonym: Bromisovalum (substance)
Synonym: Bromisovalum [Chemical/Ingredient]
Synonym: Bromoisovalerylurea
Synonym: Bromovalcarbamide
Synonym: Bromovalerylurea
Synonym: Butanamide, N-(aminocarbonyl)-2-bromo-3-methyl-
Tree Number: T6.2.34.4
database_cross_reference: ATC:N05CM03
database_cross_reference: CHV:0000002174
database_cross_reference: MSH:D001968
database_cross_reference: NCI:C76935
database_cross_reference: NCI_FDA:469GW8R486
database_cross_reference: NDDF:001436
database_cross_reference: NDFRT:N0000166305
database_cross_reference: SNM:E-7856
database_cross_reference: SNMI:C-64012
database_cross_reference: SNOMEDCT_US:53845007

Hydroxyurea
type: Class
subclass of: Urea
MCID: MC00006519
PMOID: PMO:00017548
Subclass_of: Urea
Synonym: Apo-hydroxyurea
Synonym: Carbamohydroxamic Acid
Synonym: Carbamohydroximic Acid
Synonym: Carbamoyl Oxime
Synonym: Carbamyl Hydroxamate
Synonym: HU
Synonym: HYD
Synonym: HYDROXYUREA
Synonym: Hidroxicarbamida
Synonym: Hydrea Cap 500mg
Tree Number: T6.2.34.5
database_cross_reference: ATC:L01XX05
database_cross_reference: CHV:0000006391
database_cross_reference: CSP:0113-4000
database_cross_reference: DRUGBANK:DB01005
database_cross_reference: MEDCIN:40509
database_cross_reference: MMSL:1763
database_cross_reference: MMSL:4856
database_cross_reference: MMSL:d01373
database_cross_reference: MSH:D006918
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:X6Q56QN5QC
database_cross_reference: NCI:C560
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_DCP:00782
database_cross_reference: NCI_DTP:NSC0032065
database_cross_reference: NCI_FDA:X6Q56QN5QC
database_cross_reference: NCI_NCI-GLOSS:CDR0000045308
database_cross_reference: NDDF:002635
database_cross_reference: NDFRT:N0000007293
database_cross_reference: NDFRT:N0000146101
database_cross_reference: PDQ:CDR0000040685
database_cross_reference: RCD:h55..
database_cross_reference: RXNORM:5552
database_cross_reference: SNM:E-8345
database_cross_reference: SNMI:C-78100
database_cross_reference: SNOMEDCT_US:387314007
database_cross_reference: SNOMEDCT_US:56602009
database_cross_reference: USPMG:MTHU000489
database_cross_reference: VANDF:4017733

Methylurea Compounds
type: Class
subclass of: Urea
MCID: MC00008251
PMOID: PMO:00017549
Subclass_of: Urea
Synonym: Compounds, Methylurea
Synonym: METHYLUREA CPDS
Synonym: Methylurea Compounds [Chemical/Ingredient]
Tree Number: T6.2.34.6
database_cross_reference: MSH:D008782
database_cross_reference: NDFRT:N0000166300

Ethylenethiourea
type: Class
subclass of: Thiourea
MCID: MC00004810
PMOID: PMO:00017550
Subclass_of: Thiourea
Synonym: 1,3-Ethylene-2-thiourea
Synonym: 2 Mercaptoimidazoline
Synonym: 2-Imidazolidine-2-thione
Synonym: 2-Imidazolidinethione
Synonym: 2-Mercaptoimidazoline
Synonym: 4,5-Dihydroimidazol-2(3h)-thione
Synonym: ETU
Synonym: Ethylene Thiourea
Synonym: Ethylene thiourea
Synonym: Ethylene thiourea (product)
Tree Number: T6.2.34.10.3
database_cross_reference: CHV:0000004717
database_cross_reference: LCH_NW:sh2011002553
database_cross_reference: LNC:LP34808-3
database_cross_reference: LNC:MTHU017186
database_cross_reference: MSH:D005031
database_cross_reference: NCI:C44384
database_cross_reference: NDFRT:N0000167066
database_cross_reference: RCD:X79M7
database_cross_reference: SNOMEDCT_US:256153007
database_cross_reference: SNOMEDCT_US:411479005

Organoselenium Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00043173
PMOID: PMO:00017551
Subclass_of: Organic Chemicals
Synonym: Compounds, Organoselenium
Synonym: ORGANOSELENIUM CPDS
Synonym: Organoselenium Compound
Synonym: Organoselenium Compounds [Chemical/Ingredient]
Synonym: Organoselenium compounds
Tree Number: T6.2.35
database_cross_reference: LCH_NW:sh85095573
database_cross_reference: MSH:D016566
database_cross_reference: NCI:C45565
database_cross_reference: NDFRT:N0000007804

Organosilicon Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00067306
PMOID: PMO:00017552
Subclass_of: Organic Chemicals
Synonym: ORGANOSILICON CPDS
Synonym: Organosilicon Compounds [Chemical/Ingredient]
Synonym: Organosilicon compounds
Synonym: organosilicon compound
Tree Number: T6.2.36
database_cross_reference: CSP:2707-1445
database_cross_reference: LCH_NW:sh85095574
database_cross_reference: MSH:D017646
database_cross_reference: NDFRT:N0000008206

Silicones
type: Class
subclass of: Siloxanes
MCID: MC00011865
PMOID: PMO:00017553
Subclass_of: Siloxanes
Synonym: SILICONE
Synonym: Silicone
Synonym: Silicone (substance)
Synonym: Silicone product
Synonym: Silicone product (product)
Synonym: Silicone product (substance)
Synonym: Silicones [Chemical/Ingredient]
Synonym: silicone
Synonym: silicones
Tree Number: T6.14.9.13.1
Tree Number: T6.2.36.2.1
Tree Number: T6.5.2.15.1
database_cross_reference: ATC:A03AX13
database_cross_reference: CHV:0000011347
database_cross_reference: LCH:U004316
database_cross_reference: LCH_NW:sh85122534
database_cross_reference: LNC:LP17967-8
database_cross_reference: MMSL:36230
database_cross_reference: MSH:D012828
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C28189
database_cross_reference: NCI_NCI-GLOSS:CDR0000044725
database_cross_reference: NDDF:001918
database_cross_reference: NDDF:010500
database_cross_reference: NDFRT:N0000006168
database_cross_reference: NDFRT:N0000147558
database_cross_reference: RCD:Xa4fv
database_cross_reference: RCD:x01Gr
database_cross_reference: RXNORM:9778
database_cross_reference: SNM:E-5911
database_cross_reference: SNMI:C-22301
database_cross_reference: SNOMEDCT_US:13652007
database_cross_reference: SNOMEDCT_US:350103006
database_cross_reference: VANDF:4019427

Silorane Resins
type: Class
subclass of: Siloxanes
MCID: MC00909520
PMOID: PMO:00017558
Subclass_of: Siloxanes
Synonym: Resin, Silorane
Synonym: Resins, Silorane
Synonym: Silorane
Synonym: Silorane Resin
Synonym: Silorane Resins [Chemical/Ingredient]
Synonym: Siloranes
Tree Number: T6.2.36.2.2
Tree Number: T6.5.2.15.2
database_cross_reference: MSH:D062047
database_cross_reference: NDFRT:N0000185683

Trimethylsilyl Compounds
type: Class
subclass of: Organosilicon Compounds
MCID: MC00013115
PMOID: PMO:00017559
Subclass_of: Organosilicon Compounds
Synonym: Compounds, Trimethylsilyl
Synonym: TRIMETHYLSILYL CPDS
Synonym: Trimethylsilyl Compounds [Chemical/Ingredient]
Tree Number: T6.2.36.3
database_cross_reference: MSH:D014297
database_cross_reference: NDFRT:N0000166555

Organically Modified Ceramics
type: Class
subclass of: Organosilicon Compounds
subclass of: Polymers
subclass of: PMO:00024411
MCID: MC00909617
PMOID: PMO:00017560
Subclass_of: Dental Cements
Subclass_of: Organosilicon Compounds
Subclass_of: Polymers
Synonym: Ceramic, Organically Modified
Synonym: Ceramics, Organically Modified
Synonym: Modified Ceramic, Organically
Synonym: Modified Ceramics, Organically
Synonym: Organically Modified Ceramic
Synonym: Organically Modified Ceramics [Chemical/Ingredient]
Tree Number: T6.14.5.3.9
Tree Number: T6.14.9.15
Tree Number: T6.2.36.4
Tree Number: T6.5.2.18
database_cross_reference: MSH:D063225
database_cross_reference: NDFRT:N0000185724

Isocyanates
type: Class
subclass of: Organic Chemicals
MCID: MC00063249
PMOID: PMO:00017561
Subclass_of: Organic Chemicals
Synonym: Isocyanate
Synonym: Isocyanate (substance)
Synonym: Isocyanates [Chemical/Ingredient]
Synonym: isocyanate
Synonym: isocyanates
Tree Number: T6.2.37
database_cross_reference: CHV:0000017806
database_cross_reference: CSP:0774-1559
database_cross_reference: LCH_NW:sh86000419
database_cross_reference: LNC:LP18984-2
database_cross_reference: MSH:D017953
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166549
database_cross_reference: RCD:X79BV
database_cross_reference: SNOMEDCT_US:255771001

Rotaxanes
type: Class
subclass of: Organic Chemicals
MCID: MC00367686
PMOID: PMO:00017562
Subclass_of: Organic Chemicals
Synonym: Rotaxane
Synonym: Rotaxanes [Chemical/Ingredient]
Tree Number: T6.2.38
database_cross_reference: LCH_NW:sh96010897
database_cross_reference: MSH:D043862
database_cross_reference: NDFRT:N0000166853

Catenanes
type: Class
subclass of: Organic Chemicals
MCID: MC00421566
PMOID: PMO:00017563
Subclass_of: Organic Chemicals
Synonym: Catenanes [Chemical/Ingredient]
Tree Number: T6.2.39
database_cross_reference: LCH_NW:sh96010896
database_cross_reference: MSH:D043863
database_cross_reference: NDFRT:N0000166579

DNA, Catenated
type: Class
subclass of: Catenanes
MCID: MC00421569
PMOID: PMO:00017564
Subclass_of: Catenanes
Synonym: Catenanes, DNA
Synonym: Catenated DNA
Synonym: DNA Catenanes
Synonym: DNA, Catanates
Synonym: DNA, Catenated [Chemical/Ingredient]
Tree Number: T6.2.39.1
database_cross_reference: MSH:D043864
database_cross_reference: NDFRT:N0000170679

Volatile Organic Compounds
type: Class
subclass of: Organic Chemicals
MCID: MC00715477
PMOID: PMO:00017565
Subclass_of: Organic Chemicals
Synonym: Compounds, Volatile Organic
Synonym: Organic Compounds, Volatile
Synonym: Volatile Organic Compounds [Chemical/Ingredient]
Synonym: Volatile organic compounds
Tree Number: T6.2.40
database_cross_reference: LCH_NW:sh93000972
database_cross_reference: MSH:D055549
database_cross_reference: NDFRT:N0000178853

Heterocyclic Compounds
type: Class
subclass of: Chemical and Drug
MCID: MC00006224
PMOID: PMO:00017566
Subclass_of: Chemical and Drug
Synonym: Compounds, Heterocyclic
Synonym: HETEROCYCLIC CPDS
Synonym: Heterocyclic Compound
Synonym: Heterocyclic Compounds [Chemical/Ingredient]
Synonym: Heterocyclic compound
Synonym: Heterocyclic compound (substance)
Synonym: Heterocyclic compounds
Synonym: heterocyclic compound
Synonym: heterocyclic compounds
Tree Number: T6.3
database_cross_reference: AOD:0000020708
database_cross_reference: CSP:0779-6871
database_cross_reference: LCH:U002189
database_cross_reference: LCH_NW:sh85060525
database_cross_reference: MSH:D006571
database_cross_reference: NCI:C542
database_cross_reference: NDFRT:N0000008095
database_cross_reference: SNOMEDCT_US:116280007

Heterocyclic Compounds, Fused-Ring
type: Class
subclass of: Heterocyclic Compounds
MCID: MC01054883
PMOID: PMO:00017567
Subclass_of: Heterocyclic Compounds
Synonym: Compounds, Fused-Ring Heterocyclic
Synonym: Fused-Ring Heterocyclic Compounds
Synonym: Heterocyclic Compounds, Fused Ring
Synonym: Heterocyclic Compounds, Fused-Ring [Chemical/Ingredient]
Tree Number: T6.3.1
database_cross_reference: MSH:D000072471
database_cross_reference: NDFRT:N0000193170

Heterocyclic Compounds, 2-Ring
type: Class
subclass of: Heterocyclic Compounds, Fused-Ring
MCID: MC00006226
PMOID: PMO:00017568
Subclass_of: Heterocyclic Compounds, Fused-Ring
Synonym: 2-Ring Heterocyclic Compound
Synonym: 2-Ring Heterocyclic Compounds
Synonym: 2-ring heterocyclic compounds
Synonym: Fused Heterocyclic Compounds, Two Ring
Synonym: Fused Heterocyclic Compounds, Two-Ring
Synonym: HETEROCYCLIC COMPOUNDS A 2 RING
Synonym: HETEROCYCLIC CPDS 2 RING
Synonym: Heterocyclic Compounds, 2 Ring
Synonym: Heterocyclic Compounds, 2-Ring [Chemical/Ingredient]
Synonym: Two Ring Heterocyclic Compounds
Tree Number: T6.3.1.1
database_cross_reference: AOD:0000020849
database_cross_reference: MSH:D006574
database_cross_reference: NCI:C543
database_cross_reference: NDFRT:N0000008260

Benzazepines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00001566
PMOID: PMO:00017569
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Benzazepine
Synonym: Benzazepine (substance)
Synonym: Benzazepines [Chemical/Ingredient]
Synonym: benzazepine
Synonym: benzazepines
Tree Number: T6.3.1.1.1
database_cross_reference: AOD:0000020852
database_cross_reference: CSP:0314-3400
database_cross_reference: MSH:D001552
database_cross_reference: NDFRT:N0000007524
database_cross_reference: SNOMEDCT_US:413639003

Anthramycin
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00000981
PMOID: PMO:00017574
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-
Synonym: 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1h-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-2-propenamide
Synonym: ANTHRAMYCIN
Synonym: Anthramycin [Chemical/Ingredient]
Synonym: Antramycin
Synonym: anthramycin
Tree Number: T6.3.1.2.6
database_cross_reference: AOD:0000020859
database_cross_reference: CHV:0000001244
database_cross_reference: CSP:0192-4208
database_cross_reference: MSH:D000876
database_cross_reference: NCI:C252
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_FDA:0WZD9Y66WN
database_cross_reference: NDFRT:N0000167282

Galantamine
type: Class
subclass of: Amaryllidaceae Alkaloids
MCID: MC00005390
PMOID: PMO:00017596
Subclass_of: Amaryllidaceae Alkaloids
Synonym: (-)-Galanthamine
Synonym: 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-
Synonym: Apo-galantamine
Synonym: Auro-galantamine ER
Synonym: GALANTAMINE
Synonym: Galantamin
Synonym: Galantamine (product)
Synonym: Galantamine (substance)
Synonym: Galantamine ER
Synonym: Galantamine [Chemical/Ingredient]
Tree Number: T6.3.3.27.1
database_cross_reference: ATC:N06DA04
database_cross_reference: CHV:0000005321
database_cross_reference: CSP:0091-7950
database_cross_reference: DRUGBANK:DB00674
database_cross_reference: MMSL:d04750
database_cross_reference: MSH:D005702
database_cross_reference: MTHSPL:0D3Q044KCA
database_cross_reference: NCI:C65797
database_cross_reference: NCI_FDA:0D3Q044KCA
database_cross_reference: NDDF:007026
database_cross_reference: NDFRT:N0000004833
database_cross_reference: NDFRT:N0000148691
database_cross_reference: PSY:20530
database_cross_reference: PSY:58072
database_cross_reference: RXNORM:4637
database_cross_reference: SNOMEDCT_US:323377002
database_cross_reference: SNOMEDCT_US:395727007
database_cross_reference: USPMG:MTHU000285
database_cross_reference: VANDF:4021250

Harringtonines
type: Class
subclass of: Heterocyclic Compounds, 4 or More Rings
subclass of: Alkaloids
PMOID: PMO:00017597
Subclass_of: Alkaloids
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Tree Number: T6.3.1.3.7
Tree Number: T6.3.3.10

Benzimidazoles
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00001578
PMOID: PMO:00017600
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Benzimidazole
Synonym: Benzimidazoles [Chemical/Ingredient]
Synonym: Furylbenzimidazole
Synonym: benzimidazole
Synonym: benzimidazoles
Tree Number: T6.3.1.1.2
database_cross_reference: AOD:0000020882
database_cross_reference: CHV:0000001790
database_cross_reference: CSP:0393-0157
database_cross_reference: DRUGBANK:DB02962
database_cross_reference: LCH:U000536
database_cross_reference: LCH:U005210
database_cross_reference: LCH_NW:sh85013236
database_cross_reference: MSH:D001562
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007536

Dabigatran
type: Class
subclass of: Pyridines
MCID: MC00714347
PMOID: PMO:00017601
Subclass_of: Pyridines
Synonym: DABIGATRAN
Synonym: Dabigatran (product)
Synonym: Dabigatran (substance)
Synonym: Dabigatran [Chemical/Ingredient]
Synonym: N-((2-(((4-(aminoiminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-beta-alanine
Synonym: dabigatran
Tree Number: T6.3.5.20.3
database_cross_reference: DRUGBANK:DB06695
database_cross_reference: LNC:LP135651-0
database_cross_reference: LNC:MTHU042953
database_cross_reference: MMSL:d07137
database_cross_reference: MSH:D000069604
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:I0VM4M70GC
database_cross_reference: NCI:C73224
database_cross_reference: NCI_FDA:I0VM4M70GC
database_cross_reference: NDFRT:N0000181836
database_cross_reference: NDFRT:N0000191969
database_cross_reference: RXNORM:1546356
database_cross_reference: SNOMEDCT_US:698871007
database_cross_reference: SNOMEDCT_US:714788005
database_cross_reference: USPMG:MTHU002789
database_cross_reference: VANDF:4030254

Domperidone
type: Class
subclass of: Piperidines
MCID: MC00004149
PMOID: PMO:00017603
Subclass_of: Piperidines
Synonym: 1-(3-(4-(5-chloro-2-oxo-2,3-Dihydrobenzo[D]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[D]imidazol-2(3H)-one
Synonym: 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-
Synonym: 5-chloro-1-(1-(3-(2-oxo-1-Benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
Synonym: 5-chloro-1-(1-(3-(2-oxo-2,3-Dihydrobenzo[D]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[D]imidazol-2(3H)-one
Synonym: 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Synonym: Apo-domperidone - Tab 10mg
Synonym: Ava-domperidone
Synonym: Bio-domperidone
Synonym: DOMPERIDONE
Synonym: Dom-domperidone
Tree Number: T6.3.5.16.6
database_cross_reference: ATC:A03FA03
database_cross_reference: CHV:0000004088
database_cross_reference: DRUGBANK:DB01184
database_cross_reference: LCH_NW:sh90004346
database_cross_reference: LNC:LP66331-7
database_cross_reference: LNC:MTHU026643
database_cross_reference: MEDCIN:197274
database_cross_reference: MEDCIN:198537
database_cross_reference: MSH:D004294
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5587267Z69
database_cross_reference: NCI:C454
database_cross_reference: NCI_DTP:NSC0299589
database_cross_reference: NCI_FDA:5587267Z69
database_cross_reference: NDDF:003454
database_cross_reference: NDFRT:N0000167200
database_cross_reference: NDFRT:N0000171760
database_cross_reference: PDQ:CDR0000040071
database_cross_reference: RCD:a4g..
database_cross_reference: RCD:dh7..
database_cross_reference: RCD:x019W
database_cross_reference: RXNORM:3626
database_cross_reference: SNMI:C-858C0
database_cross_reference: SNOMEDCT_US:317169006
database_cross_reference: SNOMEDCT_US:322069001
database_cross_reference: SNOMEDCT_US:32955006
database_cross_reference: SNOMEDCT_US:387181004
database_cross_reference: VANDF:4025225

Benzofurans
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00001587
PMOID: PMO:00017608
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Benzofuran
Synonym: Benzofuran (substance)
Synonym: Benzofurans [Chemical/Ingredient]
Synonym: Coumarones
Synonym: benzofuran
Synonym: coumarone
Tree Number: T6.3.1.1.3
database_cross_reference: CHV:0000001795
database_cross_reference: CSP:0395-3669
database_cross_reference: DRUGBANK:DB04179
database_cross_reference: MSH:D001572
database_cross_reference: MTH:U001736
database_cross_reference: NDFRT:N0000007548
database_cross_reference: SNOMEDCT_US:417695006

Vilazodone Hydrochloride
type: Class
subclass of: Piperazines
MCID: MC00808446
PMOID: PMO:00017609
Subclass_of: Piperazines
Synonym: 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1)
Synonym: 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}benzofuran-2-carboxamide Hydrochloride
Synonym: HCl, Vilazodone
Synonym: Hydrochloride, Vilazodone
Synonym: VILAZODONE HYDROCHLORIDE
Synonym: Vilazodone HCl
Synonym: Vilazodone Hydrochloride [Chemical/Ingredient]
Synonym: Vilazodone hydrochloride
Synonym: Vilazodone hydrochloride (substance)
Synonym: antidepressants vilazodone
Tree Number: T6.3.5.15.7
database_cross_reference: MEDCIN:307933
database_cross_reference: MMSL:27744
database_cross_reference: MSH:D000069503
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:U8HTX2GK8J
database_cross_reference: NCI:C90717
database_cross_reference: NCI_FDA:U8HTX2GK8J
database_cross_reference: NDDF:013754
database_cross_reference: NDFRT:N0000182439
database_cross_reference: NDFRT:N0000191979
database_cross_reference: RXNORM:1086768
database_cross_reference: SNOMEDCT_US:702838003
database_cross_reference: USPMG:MTHU002307
database_cross_reference: VANDF:4030484

Pterocarpans
type: Class
subclass of: Heterocyclic Compounds, 4 or More Rings
MCID: MC00377839
PMOID: PMO:00017615
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Synonym: Pterocarpans [Chemical/Ingredient]
Tree Number: T6.3.1.3.11
database_cross_reference: MSH:D036343
database_cross_reference: NDFRT:N0000167292

Benzopyrans
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
subclass of: Pyrans
MCID: MC00001592
PMOID: PMO:00017616
Subclass_of: Heterocyclic Compounds, 2-Ring
Subclass_of: Pyrans
Synonym: Benzopyran
Synonym: Benzopyran (substance)
Synonym: Benzopyrans [Chemical/Ingredient]
Synonym: Chromenes
Synonym: benzopyran
Synonym: benzopyrans
Synonym: chromene
Synonym: chromenes
Tree Number: T6.3.1.1.4
Tree Number: T6.3.5.17.2
database_cross_reference: AOD:0000020884
database_cross_reference: CHV:0000001797
database_cross_reference: CSP:0396-2545
database_cross_reference: LCH:U000541
database_cross_reference: LCH_NW:sh85013246
database_cross_reference: MSH:D001578
database_cross_reference: NDFRT:N0000007553
database_cross_reference: SNOMEDCT_US:424563009

Aflatoxins
type: Class
subclass of: PMO:00024389
MCID: MC00000461
PMOID: PMO:00017617
Subclass_of: Mycotoxins
Synonym: AFT - Aflatoxin
Synonym: Aflatoxin
Synonym: Aflatoxin (substance)
Synonym: Aflatoxins (substance)
Synonym: Aflatoxins [Chemical/Ingredient]
Synonym: Aflatoxins, NOS
Synonym: aflatoxin
Synonym: aflatoxins
Tree Number: T6.13.8.6.1
database_cross_reference: CHV:0000000802
database_cross_reference: CSP:2948-5087
database_cross_reference: LCH:U000097
database_cross_reference: LCH_NW:sh85001527
database_cross_reference: LNC:LP14070-4
database_cross_reference: LNC:MTHU010312
database_cross_reference: MSH:D000348
database_cross_reference: NCI:C213
database_cross_reference: NCI_NCI-GLOSS:CDR0000046206
database_cross_reference: NDFRT:N0000171416
database_cross_reference: RCD:Xa3dg
database_cross_reference: SNM:E-694X
database_cross_reference: SNMI:C-30810
database_cross_reference: SNOMEDCT_US:62694003

Anthocyanins
type: Class
subclass of: PMO:00020950
subclass of: PMO:00024379
MCID: MC00000976
PMOID: PMO:00017626
Subclass_of: Glycosides
Subclass_of: Pigments, Biological
Synonym: Anthocyanin
Synonym: Anthocyanin (substance)
Synonym: Anthocyanins [Chemical/Ingredient]
Synonym: anthocyanin
Synonym: anthocyanins
Tree Number: T6.13.7.2
Tree Number: T6.8.6.2
database_cross_reference: CHV:0000001239
database_cross_reference: LCH:U000272
database_cross_reference: LCH_NW:sh85005532
database_cross_reference: MSH:D000872
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C112040
database_cross_reference: NDFRT:N0000171219
database_cross_reference: SNMI:C-30702
database_cross_reference: SNOMEDCT_US:60352003

Rotenone
type: Class
subclass of: Heterocyclic Compounds, 4 or More Rings
MCID: MC00011498
PMOID: PMO:00017631
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Synonym: (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R-(2alpha,6aalpha,12aalpha))-
Synonym: ROTENONE
Synonym: Rotenone (substance)
Synonym: Rotenone [Chemical/Ingredient]
Synonym: rotenone
Tree Number: T6.3.1.3.10
database_cross_reference: CHV:0000010953
database_cross_reference: CSP:2253-8519
database_cross_reference: LCH_NW:sh88005659
database_cross_reference: MSH:D012402
database_cross_reference: MTHSPL:03L9OT429T
database_cross_reference: NCI:C76087
database_cross_reference: NCI_FDA:03L9OT429T
database_cross_reference: NDFRT:N0000167293
database_cross_reference: RCD:X808K
database_cross_reference: RXNORM:1366666
database_cross_reference: SNM:E-6903
database_cross_reference: SNMI:C-32012
database_cross_reference: SNOMEDCT_US:55792003

Citrinin
type: Class
subclass of: PMO:00024389
MCID: MC00002932
PMOID: PMO:00017649
Subclass_of: Mycotoxins
Synonym: 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R-trans)-
Synonym: Citrinin (substance)
Synonym: Citrinin [Chemical/Ingredient]
Tree Number: T6.13.8.6.3
database_cross_reference: MSH:D002953
database_cross_reference: NDFRT:N0000171419
database_cross_reference: SNMI:C-30824
database_cross_reference: SNOMEDCT_US:67538004

Esculin
type: Class
subclass of: PMO:00020974
MCID: MC00004705
PMOID: PMO:00017652
Subclass_of: Glucosides
Synonym: 2H-1-Benzopyran-2-one, 6-(beta-D-glucopyranosyloxy)-7-hydroxy-
Synonym: 6,7-Dihydroxycoumarin 6-glucoside
Synonym: 6,7-Dihydroxycoumarin-6-O-glucoside
Synonym: 6-(beta-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one
Synonym: 6-(beta-D-Glucopyranosyloxy)-7-hydroxy-cumarin
Synonym: Aesculin
Synonym: Aesculinum
Synonym: ESCULIN
Synonym: Esculetin 6-O-glucoside
Synonym: Esculin (substance)
Tree Number: T6.8.6.7.5
database_cross_reference: CHV:0000004644
database_cross_reference: DRUGBANK:DB13155
database_cross_reference: MSH:D004929
database_cross_reference: MTHSPL:1Y1L18LQAF
database_cross_reference: NCI:C83696
database_cross_reference: NCI_FDA:1Y1L18LQAF
database_cross_reference: NDDF:003706
database_cross_reference: NDDF:005476
database_cross_reference: NDFRT:N0000168437
database_cross_reference: RXNORM:1314351
database_cross_reference: SNOMEDCT_US:713209005

Furocoumarins
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00005355
PMOID: PMO:00017653
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Furanocoumarin
Synonym: Furanocoumarins
Synonym: Furocoumarin
Synonym: Furocoumarin (substance)
Synonym: Furocoumarins [Chemical/Ingredient]
Synonym: furocoumarin
Tree Number: T6.3.1.2.21
database_cross_reference: CSP:0397-0201
database_cross_reference: MSH:D011564
database_cross_reference: NCI:C112046
database_cross_reference: NDFRT:N0000191057
database_cross_reference: SNMI:C-30208
database_cross_reference: SNOMEDCT_US:36466007

Pyranocoumarins
type: Class
subclass of: Pyrans
MCID: MC00377921
PMOID: PMO:00017667
Subclass_of: Pyrans
Synonym: Pyranocoumarins [Chemical/Ingredient]
Tree Number: T6.3.5.17.9
database_cross_reference: MSH:D039681
database_cross_reference: NDFRT:N0000167015

Novobiocin
type: Class
subclass of: PMO:00020950
MCID: MC00009027
PMOID: PMO:00017669
Subclass_of: Glycosides
Synonym: Benzamide, N-(7-((3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-beta-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl)-4-hydroxy-3-(3-methyl-2-butenyl)-
Synonym: Crystallinic Acid
Synonym: N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide
Synonym: NBC
Synonym: NOVOBIOCIN
Synonym: Novobiocin (substance)
Synonym: Novobiocin [Chemical/Ingredient]
Synonym: Novobiocin product
Synonym: Novobiocin product (product)
Synonym: Novobiocina
Tree Number: T6.8.6.10
database_cross_reference: CHV:0000008792
database_cross_reference: CSP:0203-4078
database_cross_reference: DRUGBANK:DB01051
database_cross_reference: LNC:LP16168-4
database_cross_reference: LNC:MTHU007486
database_cross_reference: MMSL:d01116
database_cross_reference: MSH:D009675
database_cross_reference: MTHSPL:17EC19951N
database_cross_reference: NCI:C705
database_cross_reference: NCI_DCP:30244
database_cross_reference: NCI_DTP:NSC0002382
database_cross_reference: NCI_FDA:17EC19951N
database_cross_reference: NCI_NCI-GLOSS:CDR0000045185
database_cross_reference: NDDF:002761
database_cross_reference: NDFRT:N0000005743
database_cross_reference: NDFRT:N0000147947
database_cross_reference: PDQ:CDR0000039195
database_cross_reference: RXNORM:7538
database_cross_reference: SNM:E-7214
database_cross_reference: SNMI:C-52260
database_cross_reference: SNOMEDCT_US:371187001
database_cross_reference: SNOMEDCT_US:90220005
database_cross_reference: VANDF:4019861

Ochratoxins
type: Class
subclass of: PMO:00024389
MCID: MC00009097
PMOID: PMO:00017671
Subclass_of: Mycotoxins
Synonym: Ochratoxin
Synonym: Ochratoxins (substance)
Synonym: Ochratoxins [Chemical/Ingredient]
Synonym: ochratoxin
Synonym: ochratoxins
Tree Number: T6.13.8.6.8
database_cross_reference: CHV:0000008887
database_cross_reference: CSP:2948-5085
database_cross_reference: LCH_NW:sh91002914
database_cross_reference: MSH:D009793
database_cross_reference: NDFRT:N0000171406
database_cross_reference: RCD:Xa3dp
database_cross_reference: SNMI:C-30820
database_cross_reference: SNOMEDCT_US:22424004

Benzoxazoles
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00001597
PMOID: PMO:00017681
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Benzoxazoles [Chemical/Ingredient]
Tree Number: T6.3.1.1.7
database_cross_reference: MSH:D001583
database_cross_reference: NDFRT:N0000007555

Benzoxepins
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00001598
PMOID: PMO:00017685
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Benzoxepins [Chemical/Ingredient]
Tree Number: T6.3.1.1.8
database_cross_reference: MSH:D001584
database_cross_reference: NDFRT:N0000166943

Indazoles
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00006793
PMOID: PMO:00017686
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Indazole
Synonym: Indazole (substance)
Synonym: Indazoles [Chemical/Ingredient]
Tree Number: T6.3.1.1.9
database_cross_reference: MSH:D007191
database_cross_reference: NDFRT:N0000007946
database_cross_reference: SNOMEDCT_US:422102009

Indoles
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00006810
PMOID: PMO:00017688
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Indole
Synonym: Indole Compound
Synonym: Indoles [Chemical/Ingredient]
Synonym: indoles
Tree Number: T6.3.1.1.10
database_cross_reference: AOD:0000020895
database_cross_reference: CHV:0000006667
database_cross_reference: DRUGBANK:DB04532
database_cross_reference: MSH:D007211
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C54677
database_cross_reference: NCI_DCP:02109
database_cross_reference: NDFRT:N0000008052

Adrenochrome
type: Class
subclass of: PMO:00024379
MCID: MC00000438
PMOID: PMO:00017689
Subclass_of: Pigments, Biological
Synonym: 1H-Indole-5,6-dione, 2,3-dihydro-3-hydroxy-1-methyl-
Synonym: Adrenochrome (substance)
Synonym: Adrenochrome - chemical
Synonym: Adrenochrome - chemical (substance)
Synonym: Adrenochrome [Chemical/Ingredient]
Tree Number: T6.13.7.1
database_cross_reference: DRUGBANK:DB09012
database_cross_reference: MSH:D000323
database_cross_reference: NDFRT:N0000171234
database_cross_reference: SNMI:F-62B10
database_cross_reference: SNOMEDCT_US:360245004
database_cross_reference: SNOMEDCT_US:37973003

Carbazoles
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00002215
PMOID: PMO:00017691
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Carbazoles [Chemical/Ingredient]
Tree Number: T6.3.1.2.7
database_cross_reference: MSH:D002227
database_cross_reference: NDFRT:N0000008127

Staurosporine
type: Class
subclass of: Indole Alkaloids
MCID: MC00038232
PMOID: PMO:00017694
Subclass_of: Indole Alkaloids
Synonym: (9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Synonym: 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
Synonym: CGP-39360
Synonym: STAUROSPORINE
Synonym: Staurosporine [Chemical/Ingredient]
Synonym: staurosporine
Tree Number: T6.3.3.25.5
database_cross_reference: CHV:0000014862
database_cross_reference: CSP:4005-0057
database_cross_reference: DRUGBANK:DB02010
database_cross_reference: MSH:D019311
database_cross_reference: NCI:C1237
database_cross_reference: NCI_DCP:01722
database_cross_reference: NCI_DTP:NSC0618487
database_cross_reference: NCI_FDA:H88EPA0A3N
database_cross_reference: NCI_NCI-GLOSS:CDR0000044852
database_cross_reference: NDFRT:N0000167256

Carbolines
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
subclass of: Pyridines
MCID: MC00002233
PMOID: PMO:00017695
Subclass_of: Heterocyclic Compounds, 3-Ring
Subclass_of: Pyridines
Synonym: Carbolines [Chemical/Ingredient]
Synonym: Pyrido(4,3-b)Indoles
Synonym: carboline
Synonym: carbolines
Tree Number: T6.3.1.2.8
Tree Number: T6.3.5.20.6
database_cross_reference: CHV:0000002390
database_cross_reference: CSP:2511-5985
database_cross_reference: LCH:U000783
database_cross_reference: LCH_NW:sh85020089
database_cross_reference: MSH:D002243
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007499

Cytochalasins
type: Class
subclass of: PMO:00024389
MCID: MC00003490
PMOID: PMO:00017697
Subclass_of: Mycotoxins
Synonym: Cytochalasin
Synonym: Cytochalasin (substance)
Synonym: Cytochalasin, NOS
Synonym: Cytochalasins [Chemical/Ingredient]
Synonym: cytochalasin
Tree Number: T6.13.8.6.4
database_cross_reference: CSP:2948-5089
database_cross_reference: LCH:U001249
database_cross_reference: LCH_NW:sh85035226
database_cross_reference: MSH:D003572
database_cross_reference: NDFRT:N0000171412
database_cross_reference: SNMI:C-30826
database_cross_reference: SNOMEDCT_US:73591009

Gliotoxin
type: Class
subclass of: PMO:00024389
MCID: MC00005633
PMOID: PMO:00017700
Subclass_of: Mycotoxins
Synonym: (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
Synonym: 10H-3,10a-Epidithiopyrazino(1,2-a)indole-1,4-dione, 2,3,5a,6-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-
Synonym: Aspergillin
Synonym: GLIOTOXIN
Synonym: Gliotoxin [Chemical/Ingredient]
Synonym: Gliotoxins
Tree Number: T6.13.8.6.5
database_cross_reference: MSH:D005912
database_cross_reference: MTHSPL:5L648PH06K
database_cross_reference: NCI:C63680
database_cross_reference: NCI_DCP:09668
database_cross_reference: NDFRT:N0000171421
database_cross_reference: RXNORM:1661743

Indoleacetic Acids
type: Class
subclass of: Acids, Heterocyclic
MCID: MC00006809
PMOID: PMO:00017706
Subclass_of: Acids, Heterocyclic
Synonym: Acids, Indoleacetic
Synonym: Acids, Indolylacetic
Synonym: Indoleacetic Acids [Chemical/Ingredient]
Synonym: Indolylacetic Acids
Tree Number: T6.3.2.2
database_cross_reference: MSH:D007210
database_cross_reference: NDFRT:N0000008051

Hydroxyindoleacetic Acid
type: Class
subclass of: Indoleacetic Acids
MCID: MC00006501
PMOID: PMO:00017707
Subclass_of: Indoleacetic Acids
Synonym: 1H-Indole-3-acetic acid, 5-hydroxy-
Synonym: 5 Hydroxy 3 Indoleacetic Acid
Synonym: 5 Hydroxyindolamine Acetic Acid
Synonym: 5 hydroxyindoleacetic acid
Synonym: 5-HIAA
Synonym: 5-HIAA - 5-Hydroxyindole acetic acid
Synonym: 5-HIAA-5-OH indole acetic acid
Synonym: 5-Hydroxy-3-Indoleacetic Acid
Synonym: 5-Hydroxy-indoleacetic acid
Synonym: 5-Hydroxy-indoleacetic acid (substance)
Tree Number: T6.3.2.2.1
database_cross_reference: AOD:0000020902
database_cross_reference: AOD:0000029087
database_cross_reference: AOD:0000029089
database_cross_reference: AOD:0000029090
database_cross_reference: CHV:0000006381
database_cross_reference: CSP:0397-1274
database_cross_reference: MSH:D006897
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C28157
database_cross_reference: NCI_NCI-GLOSS:CDR0000044314
database_cross_reference: NDFRT:N0000167320
database_cross_reference: PSY:23658
database_cross_reference: RCD:X80Ml
database_cross_reference: SNM:F-11510
database_cross_reference: SNMI:F-61510
database_cross_reference: SNOMEDCT_US:259543004
database_cross_reference: SNOMEDCT_US:709614001
database_cross_reference: SNOMEDCT_US:86832006

Etodolac
type: Class
subclass of: Indoleacetic Acids
MCID: MC00026442
PMOID: PMO:00017708
Subclass_of: Indoleacetic Acids
Synonym: (+-)-1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
Synonym: (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid
Synonym: 1,3,4,9-Tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic Acid
Synonym: 1,3,4,9-Tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid
Synonym: 1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
Synonym: 1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid
Synonym: Acid, Etodolic
Synonym: Bodopine
Synonym: Dolarit
Synonym: Dolchis
Tree Number: T6.3.2.2.2
database_cross_reference: ATC:M01AB08
database_cross_reference: CHV:0000013978
database_cross_reference: DRUGBANK:DB00749
database_cross_reference: LNC:LP18959-4
database_cross_reference: LNC:MTHU007028
database_cross_reference: MEDCIN:48394
database_cross_reference: MMSL:4707
database_cross_reference: MMSL:8937
database_cross_reference: MMSL:d00851
database_cross_reference: MSH:D017308
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2M36281008
database_cross_reference: NCI:C47526
database_cross_reference: NCI_DCP:9768
database_cross_reference: NCI_FDA:2M36281008
database_cross_reference: NDDF:003587
database_cross_reference: NDFRT:N0000006249
database_cross_reference: NDFRT:N0000147659
database_cross_reference: RCD:j24..
database_cross_reference: RXNORM:24605
database_cross_reference: SNOMEDCT_US:108510003
database_cross_reference: SNOMEDCT_US:363593008
database_cross_reference: SNOMEDCT_US:386860005
database_cross_reference: USPMG:MTHU000056
database_cross_reference: VANDF:4019559

Sporidesmins
type: Class
subclass of: PMO:00024389
MCID: MC00012165
PMOID: PMO:00017716
Subclass_of: Mycotoxins
Synonym: Sporidesmins [Chemical/Ingredient]
Tree Number: T6.13.8.6.12
database_cross_reference: MSH:D013173
database_cross_reference: NDFRT:N0000171409

Bufotenin
type: Class
subclass of: PMO:00024247
MCID: MC00002004
PMOID: PMO:00017720
Subclass_of: Amphibian Venoms
Synonym: 1H-Indol-5-ol, 3-(2-(dimethylamino)ethyl)-
Synonym: 3-[2-(dimethylamino)ethyl]-5-indolol
Synonym: 3-[2-(dimethylamino)ethyl]indol-5-ol
Synonym: 3-[β-(dimethylamino)ethyl]-5-hydroxyindole
Synonym: 5 Hydroxy N,N dimethyltryptamine
Synonym: 5-Hydroxy-N,N-dimethyltryptamine
Synonym: 5-hydroxy-N,N-dimethyltryptamine
Synonym: 5-hydroxy-dimethyltryptamine
Synonym: Bufotenin [Chemical/Ingredient]
Synonym: Bufotenine
Tree Number: T6.12.12.1.3
database_cross_reference: AOD:0000000763
database_cross_reference: AOD:0000021347
database_cross_reference: AOD:0000021348
database_cross_reference: AOD:0000021350
database_cross_reference: CHV:0000002214
database_cross_reference: CSP:0397-3775
database_cross_reference: CSP:2484-5754
database_cross_reference: DRUGBANK:DB01445
database_cross_reference: LNC:LP16809-3
database_cross_reference: LNC:MTHU003244
database_cross_reference: MSH:D002027
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171437
database_cross_reference: PSY:07060
database_cross_reference: SNMI:C-34213
database_cross_reference: SNOMEDCT_US:56147009

Melatonin
type: Class
subclass of: Hormones
MCID: MC00008003
PMOID: PMO:00017721
Subclass_of: Hormones
Synonym: 5-Methoxy-N-acetyltryptamine
Synonym: 5-methoxy-N-acetyltryptamine
Synonym: Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-
Synonym: MELATONIN
Synonym: MIH
Synonym: MLT
Synonym: Medi-doze Rx Sleep Aid
Synonym: Mela-T
Synonym: Melatol
Synonym: Melatonin (substance)
Tree Number: T6.6.2.5
database_cross_reference: AOD:0000018731
database_cross_reference: AOD:0000028372
database_cross_reference: AOD:0000028374
database_cross_reference: ATC:N05CH01
database_cross_reference: CHV:0000007900
database_cross_reference: CSP:2334-4121
database_cross_reference: DRUGBANK:DB01065
database_cross_reference: FMA:74644
database_cross_reference: LCH:U002892
database_cross_reference: LCH_NW:sh85083394
database_cross_reference: LNC:LP15036-4
database_cross_reference: LNC:MTHU002350
database_cross_reference: MMSL:5037
database_cross_reference: MMSL:5609
database_cross_reference: MMSL:d04058
database_cross_reference: MSH:D008550
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:JL5DK93RCL
database_cross_reference: NCI:C2267
database_cross_reference: NCI_NCI-GLOSS:CDR0000440118
database_cross_reference: NDDF:005039
database_cross_reference: NDFRT:N0000010145
database_cross_reference: NDFRT:N0000148757
database_cross_reference: PDQ:CDR0000042346
database_cross_reference: PSY:30540
database_cross_reference: RXNORM:6711
database_cross_reference: SNM:F-27820
database_cross_reference: SNMI:F-B7080
database_cross_reference: SNOMEDCT_US:116523008
database_cross_reference: SNOMEDCT_US:41199001
database_cross_reference: UWDA:74644
database_cross_reference: VANDF:4021324

Psilocybin
type: Class
subclass of: Indole Alkaloids
MCID: MC00010862
PMOID: PMO:00017722
Subclass_of: Indole Alkaloids
Synonym: 1H-Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen phosphate (ester)
Synonym: 3-(2-(Dimethylamino)ethyl)-1H-indol-4-ol Dihydrogen Phosphate Ester
Synonym: 4-Phosphoryloxy-omega-N,N-dimethyltryptamine
Synonym: Indocybin
Synonym: PSILOCYBINE
Synonym: Psilocibin
Synonym: Psilocybin (substance)
Synonym: Psilocybin [Chemical/Ingredient]
Synonym: Psilocybin [dup] (substance)
Synonym: Psilocybine
Tree Number: T6.3.3.25.4
database_cross_reference: AOD:0000000754
database_cross_reference: AOD:0000021346
database_cross_reference: CHV:0000010307
database_cross_reference: CSP:0397-7996
database_cross_reference: DRUGBANK:DB11664
database_cross_reference: LNC:LP17245-9
database_cross_reference: LNC:MTHU007606
database_cross_reference: MSH:D011562
database_cross_reference: NCI:C62529
database_cross_reference: NCI_FDA:2RV7212BP0
database_cross_reference: NCI_NCI-GLOSS:CDR0000644328
database_cross_reference: NCI_NCI-GLOSS:CDR0000659614
database_cross_reference: NDFRT:N0000166966
database_cross_reference: PDQ:CDR0000487535
database_cross_reference: PSY:41310
database_cross_reference: RCD:Ub18Y
database_cross_reference: SNM:E-7881
database_cross_reference: SNMI:C-63A41
database_cross_reference: SNOMEDCT_US:229007003
database_cross_reference: SNOMEDCT_US:53513007

Delavirdine
type: Class
subclass of: Piperazines
MCID: MC00100410
PMOID: PMO:00017723
Subclass_of: Piperazines
Synonym: (N-[2-[4-[3-(1-Methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide)
Synonym: 1-(3-((1-Methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine
Synonym: 2-(4-(5-Methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine
Synonym: DELAVIRDINE
Synonym: Delavirdin
Synonym: Delavirdina
Synonym: Delavirdine (product)
Synonym: Delavirdine (substance)
Synonym: Delavirdine [Chemical/Ingredient]
Synonym: Delavirdinum
Tree Number: T6.3.5.15.33
database_cross_reference: ATC:J05AG02
database_cross_reference: CHV:0000027749
database_cross_reference: CSP:4007-0036
database_cross_reference: DRUGBANK:DB00705
database_cross_reference: LNC:LP21173-7
database_cross_reference: LNC:MTHU012993
database_cross_reference: MMSL:4541
database_cross_reference: MMSL:d04119
database_cross_reference: MSH:D020008
database_cross_reference: MTHSPL:DOL5F9JD3E
database_cross_reference: NCI:C65366
database_cross_reference: NCI_FDA:DOL5F9JD3E
database_cross_reference: NDDF:006463
database_cross_reference: NDFRT:N0000007358
database_cross_reference: NDFRT:N0000022056
database_cross_reference: RXNORM:83816
database_cross_reference: SNOMEDCT_US:108710001
database_cross_reference: SNOMEDCT_US:386155009
database_cross_reference: USPMG:MTHU000653
database_cross_reference: VANDF:4024051

Indole Alkaloids
type: Class
subclass of: Alkaloids
MCID: MC00337797
PMOID: PMO:00017725
Subclass_of: Alkaloids
Synonym: Alkaloids, Indole
Synonym: Indole Alkaloids [Chemical/Ingredient]
Synonym: Indole alkaloids
Tree Number: T6.3.3.25
database_cross_reference: LCH_NW:sh85065726
database_cross_reference: MSH:D026121
database_cross_reference: NDFRT:N0000011188

Harmaline
type: Class
subclass of: Indole Alkaloids
MCID: MC00005948
PMOID: PMO:00017726
Subclass_of: Indole Alkaloids
Synonym: 3H-Pyrido(3,4-b)indole, 4,9-dihydro-7-methoxy-1-methyl-
Synonym: Dihydroharmine
Synonym: Harmaline (substance)
Synonym: Harmaline [Chemical/Ingredient]
Synonym: Harmidine
Synonym: harmaline
Tree Number: T6.3.3.25.1
database_cross_reference: CHV:0000005804
database_cross_reference: CSP:2511-5985
database_cross_reference: DRUGBANK:DB13875
database_cross_reference: MSH:D006246
database_cross_reference: NDFRT:N0000167258
database_cross_reference: SNM:E-6931
database_cross_reference: SNMI:C-30622
database_cross_reference: SNOMEDCT_US:23783000

Harmine
type: Class
subclass of: Indole Alkaloids
MCID: MC00005949
PMOID: PMO:00017727
Subclass_of: Indole Alkaloids
Synonym: 1-Methyl-7-methoxy-beta-carboline
Synonym: 6-Methoxyharman
Synonym: 7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole
Synonym: 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-
Synonym: Banisterine
Synonym: Banisterine (substance)
Synonym: HARMINE
Synonym: Harmine (substance)
Synonym: Harmine [Chemical/Ingredient]
Synonym: Leucoharmine
Tree Number: T6.3.3.25.2
database_cross_reference: AOD:0000020950
database_cross_reference: MSH:D006247
database_cross_reference: NCI:C97713
database_cross_reference: NCI_FDA:4FHH5G48T7
database_cross_reference: NDFRT:N0000167259
database_cross_reference: SNM:E-6932
database_cross_reference: SNMI:C-30397
database_cross_reference: SNMI:C-30621
database_cross_reference: SNOMEDCT_US:42013002
database_cross_reference: SNOMEDCT_US:53198008

Lyngbya Toxins
type: Class
subclass of: PMO:00024388
MCID: MC00007768
PMOID: PMO:00017728
Subclass_of: Marine Toxins
Synonym: Lyngbya Toxins [Chemical/Ingredient]
Synonym: Toxins, Lyngbya
Tree Number: T6.13.8.5.5
database_cross_reference: MSH:D008235
database_cross_reference: NDFRT:N0000171401

Secologanin Tryptamine Alkaloids
type: Class
subclass of: Indole Alkaloids
MCID: MC00516307
PMOID: PMO:00017729
Subclass_of: Indole Alkaloids
Synonym: Alkaloids, Monoterpenoid Indole
Synonym: Alkaloids, Secologanin Indole
Synonym: Alkaloids, Secologanin Tryptamine
Synonym: Alkaloids, Terpenoid Indole
Synonym: Indole Alkaloids, Monoterpenoid
Synonym: Indole Alkaloids, Secologanin
Synonym: Indole Alkaloids, Terpenoid
Synonym: Monoterpenoid Indole Alkaloids
Synonym: Secologanin Indole Alkaloids
Synonym: Secologanin Tryptamine Alkaloids [Chemical/Ingredient]
Tree Number: T6.3.3.25.6
database_cross_reference: MSH:D046948
database_cross_reference: NDFRT:N0000011187

Indolizines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00006811
PMOID: PMO:00017741
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Indolizines [Chemical/Ingredient]
Synonym: indolizine
Tree Number: T6.3.1.1.11
database_cross_reference: CSP:0397-4780
database_cross_reference: MSH:D007212
database_cross_reference: MTH:U002007
database_cross_reference: NDFRT:N0000166932

Isoquinolines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00007113
PMOID: PMO:00017743
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: 2 benzazine
Synonym: Isoquinoline
Synonym: Isoquinolines [Chemical/Ingredient]
Synonym: isoquinoline
Synonym: isoquinolines
Tree Number: T6.3.1.1.12
database_cross_reference: AOD:0000020911
database_cross_reference: CHV:0000006966
database_cross_reference: CSP:2530-5166
database_cross_reference: DRUGBANK:DB04329
database_cross_reference: MSH:D007546
database_cross_reference: MTH:U002022
database_cross_reference: NDFRT:N0000007960

Emetine
type: Class
subclass of: Alkaloids
MCID: MC00004383
PMOID: PMO:00017745
Subclass_of: Alkaloids
Synonym: EMETINE
Synonym: Emetan, 6',7',10,11-tetramethoxy-
Synonym: Emetine (product)
Synonym: Emetine (substance)
Synonym: Emetine - chemical
Synonym: Emetine - chemical (substance)
Synonym: Emetine [Chemical/Ingredient]
Synonym: Ipecine
Synonym: Methylcephaeline
Synonym: emetine
Tree Number: T6.3.3.8
database_cross_reference: AOD:0000020912
database_cross_reference: ATC:P01AX02
database_cross_reference: CHV:0000004392
database_cross_reference: CSP:0091-7950
database_cross_reference: LCH:U001561
database_cross_reference: LCH_NW:sh85042776
database_cross_reference: LNC:LP16126-2
database_cross_reference: LNC:MTHU003373
database_cross_reference: MSH:D004640
database_cross_reference: NCI:C81578
database_cross_reference: NCI_FDA:X8D5EPO80M
database_cross_reference: NDDF:004874
database_cross_reference: NDFRT:N0000006145
database_cross_reference: NDFRT:N0000147834
database_cross_reference: RXNORM:3820
database_cross_reference: SNM:E-7376
database_cross_reference: SNMI:C-56110
database_cross_reference: SNOMEDCT_US:12559001
database_cross_reference: SNOMEDCT_US:363725007
database_cross_reference: SNOMEDCT_US:373466009
database_cross_reference: VANDF:4019743

Noscapine
type: Class
subclass of: Opiate Alkaloids
MCID: MC00009018
PMOID: PMO:00017747
Subclass_of: Opiate Alkaloids
Synonym: 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (S-(R*,S*))-
Synonym: NOSCAPINE
Synonym: Narcotine
Synonym: Noscapine (product)
Synonym: Noscapine (substance)
Synonym: Noscapine [Chemical/Ingredient]
Synonym: narcotine
Synonym: noscapine
Synonym: noscapine (medication)
Tree Number: T6.3.3.30.2
database_cross_reference: ATC:R05DA07
database_cross_reference: CHV:0000008785
database_cross_reference: MEDCIN:41495
database_cross_reference: MSH:D009665
database_cross_reference: NCI:C80589
database_cross_reference: NCI_FDA:8V32U4AOQU
database_cross_reference: NDDF:001654
database_cross_reference: NDFRT:N0000166975
database_cross_reference: RCD:cg6..
database_cross_reference: RXNORM:7533
database_cross_reference: SNM:E-7847
database_cross_reference: SNMI:C-88165
database_cross_reference: SNOMEDCT_US:387437002
database_cross_reference: SNOMEDCT_US:76696004

Solifenacin Succinate
type: Class
subclass of: Quinuclidines
MCID: MC00522537
PMOID: PMO:00017752
Subclass_of: Quinuclidines
Synonym: Quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate
Synonym: SOLIFENACIN SUCCINATE
Synonym: Solifenacin Succinate [Chemical/Ingredient]
Synonym: Solifenacin succinate
Synonym: Solifenacin succinate (substance)
Synonym: Succinate, Solifenacin
Synonym: solifenacin succinate
Synonym: solifenacin succinate (medication)
Tree Number: T6.3.4.3.1
database_cross_reference: DRUGBANK:DB01591
database_cross_reference: MEDCIN:300053
database_cross_reference: MMSL:19082
database_cross_reference: MSH:D000069464
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:KKA5DLD701
database_cross_reference: NCI:C73805
database_cross_reference: NCI_FDA:KKA5DLD701
database_cross_reference: NDDF:008713
database_cross_reference: NDFRT:N0000148871
database_cross_reference: NDFRT:N0000191951
database_cross_reference: RXNORM:476588
database_cross_reference: SNOMEDCT_US:426324001
database_cross_reference: USPMG:MTHU001236
database_cross_reference: VANDF:4021510

Salsoline Alkaloids
type: Class
subclass of: Alkaloids
MCID: MC00011577
PMOID: PMO:00017753
Subclass_of: Alkaloids
Synonym: Alkaloids, Salsoline
Synonym: Salsoline Alkaloids [Chemical/Ingredient]
Synonym: salsoline alkaloids
Tree Number: T6.3.3.17
database_cross_reference: AOD:0000020532
database_cross_reference: MSH:D012490
database_cross_reference: NDFRT:N0000166981

Benzylisoquinolines
type: Class
subclass of: Alkaloids
MCID: MC00421593
PMOID: PMO:00017754
Subclass_of: Alkaloids
Synonym: Benzyl Isoquinolines
Synonym: Benzyl-Isoquinolines
Synonym: Benzylisoquinolines [Chemical/Ingredient]
Tree Number: T6.3.3.26
database_cross_reference: MSH:D044182
database_cross_reference: NDFRT:N0000011356

Aporphines
type: Class
subclass of: Benzylisoquinolines
subclass of: Heterocyclic Compounds, 4 or More Rings
MCID: MC00001172
PMOID: PMO:00017755
Subclass_of: Benzylisoquinolines
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Synonym: Aporphines [Chemical/Ingredient]
Synonym: aporphine
Synonym: aporphines
Tree Number: T6.3.1.3.1
Tree Number: T6.3.3.26.1
database_cross_reference: AOD:0000020543
database_cross_reference: CSP:0091-7950
database_cross_reference: MSH:D001060
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007979

Bicuculline
type: Class
subclass of: Benzylisoquinolines
MCID: MC00001708
PMOID: PMO:00017758
Subclass_of: Benzylisoquinolines
Synonym: 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
Synonym: Bicculine
Synonym: Bicucullin
Synonym: Bicuculline [Chemical/Ingredient]
Synonym: Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))-
Synonym: bicuculline
Synonym: d-Bicuculline
Tree Number: T6.3.3.26.3
database_cross_reference: AOD:0000020505
database_cross_reference: CSP:2530-5479
database_cross_reference: DRUGBANK:DB11562
database_cross_reference: MSH:D001640
database_cross_reference: NDFRT:N0000166980
database_cross_reference: PSY:05895

Papaverine
type: Class
subclass of: Benzylisoquinolines
subclass of: Opiate Alkaloids
MCID: MC00009687
PMOID: PMO:00017759
Subclass_of: Benzylisoquinolines
Subclass_of: Opiate Alkaloids
Synonym: Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-
Synonym: PAP
Synonym: PAPAVERINE
Synonym: Papaverine (product)
Synonym: Papaverine (substance)
Synonym: Papaverine [Chemical/Ingredient]
Synonym: papaverine
Tree Number: T6.3.3.26.4
Tree Number: T6.3.3.30.3
database_cross_reference: AOD:0000020580
database_cross_reference: ATC:A03AD01
database_cross_reference: ATC:G04BE02
database_cross_reference: CHV:0000009243
database_cross_reference: CSP:2530-5634
database_cross_reference: DRUGBANK:DB01113
database_cross_reference: LNC:LP18145-0
database_cross_reference: LNC:MTHU003466
database_cross_reference: MMSL:d00695
database_cross_reference: MSH:D010208
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:DAA13NKG2Q
database_cross_reference: NCI:C726
database_cross_reference: NCI_DCP:30427
database_cross_reference: NCI_DTP:NSC0136630
database_cross_reference: NCI_FDA:DAA13NKG2Q
database_cross_reference: NDDF:004522
database_cross_reference: NDFRT:N0000007360
database_cross_reference: NDFRT:N0000147960
database_cross_reference: PDQ:CDR0000039545
database_cross_reference: PSY:36270
database_cross_reference: RCD:gh3..
database_cross_reference: RXNORM:7895
database_cross_reference: SNM:E-7973
database_cross_reference: SNMI:C-815D0
database_cross_reference: SNOMEDCT_US:346607007
database_cross_reference: SNOMEDCT_US:372784001
database_cross_reference: SNOMEDCT_US:58467001
database_cross_reference: VANDF:4019875

Naphthyridines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00008661
PMOID: PMO:00017762
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Naphthyridines [Chemical/Ingredient]
Tree Number: T6.3.1.1.13
database_cross_reference: LCH_NW:sh2007020075
database_cross_reference: MSH:D009287
database_cross_reference: NDFRT:N0000007815

Piperoxan
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
subclass of: Dioxanes
subclass of: Piperidines
MCID: MC00010239
PMOID: PMO:00017764
Subclass_of: Dioxanes
Subclass_of: Heterocyclic Compounds, 2-Ring
Subclass_of: Piperidines
Synonym: PIPEROXAN
Synonym: Piperidine, 1-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)-
Synonym: Piperoxan (substance)
Synonym: Piperoxan [Chemical/Ingredient]
Synonym: Piperoxane
Synonym: piperoxan
Tree Number: T6.3.1.1.14
Tree Number: T6.3.5.16.26
Tree Number: T6.3.5.7.2
database_cross_reference: MSH:D010883
database_cross_reference: NCI:C66399
database_cross_reference: NCI_FDA:9ZCS27634Y
database_cross_reference: NDDF:001848
database_cross_reference: NDFRT:N0000167201
database_cross_reference: SNM:E-7514
database_cross_reference: SNMI:C-684B1
database_cross_reference: SNOMEDCT_US:21235009

Pteridines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00010888
PMOID: PMO:00017765
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Pteridine
Synonym: Pteridine (substance)
Synonym: Pteridines [Chemical/Ingredient]
Synonym: Pyrazinopyrimidines
Synonym: pteridine
Synonym: pteridines
Tree Number: T6.3.1.1.15
database_cross_reference: AOD:0000020920
database_cross_reference: CHV:0000010353
database_cross_reference: CSP:2486-5948
database_cross_reference: LCH:U003926
database_cross_reference: LCH_NW:sh85108545
database_cross_reference: MSH:D011621
database_cross_reference: NDFRT:N0000008032
database_cross_reference: SNMI:F-62B90
database_cross_reference: SNOMEDCT_US:36326009

Flavins
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
subclass of: Coenzymes
subclass of: PMO:00024379
MCID: MC00005159
PMOID: PMO:00017766
Subclass_of: Coenzymes
Subclass_of: Heterocyclic Compounds, 3-Ring
Subclass_of: Pigments, Biological
Synonym: Flavins [Chemical/Ingredient]
Synonym: flavin
Synonym: flavins
Tree Number: T6.13.7.6
Tree Number: T6.3.1.2.16
Tree Number: T6.7.1.5
database_cross_reference: AOD:0000020922
database_cross_reference: CHV:0000005083
database_cross_reference: CSP:1153-3934
database_cross_reference: LCH:U001813
database_cross_reference: LCH_NW:sh85049030
database_cross_reference: MSH:D005415
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008037

Riboflavin
type: Class
subclass of: Flavins
MCID: MC00011378
PMOID: PMO:00017767
Subclass_of: Flavins
Synonym: 1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
Synonym: 6,7-Dimethyl-9-D-ribitylisoalloxazine
Synonym: 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
Synonym: 7,8-Dimethyl-10-ribitylisoalloxazine
Synonym: Adult Infuvite Multiple Vitamins
Synonym: Alertonic
Synonym: Allbee With C 550 Cap
Synonym: Allbee With Vitamin C Cap
Synonym: Alsimine W Vitamins A D
Synonym: Am Caps
Tree Number: T6.13.7.6.1
Tree Number: T6.7.1.5.1
database_cross_reference: AOD:0000018237
database_cross_reference: ATC:A11HA04
database_cross_reference: CHV:0000010877
database_cross_reference: CSP:3147-2745
database_cross_reference: DRUGBANK:DB00140
database_cross_reference: LCH_NW:sh85143964
database_cross_reference: LNC:LP15853-2
database_cross_reference: LNC:MTHU007595
database_cross_reference: MEDCIN:41298
database_cross_reference: MEDLINEPLUS:5376
database_cross_reference: MMSL:5060
database_cross_reference: MMSL:5062
database_cross_reference: MMSL:5422
database_cross_reference: MMSL:5683
database_cross_reference: MMSL:d00409
database_cross_reference: MSH:D012256
database_cross_reference: MTH:U002226
database_cross_reference: MTHSPL:TLM2976OFR
database_cross_reference: NCI:C808
database_cross_reference: NCI_CDISC:C74898
database_cross_reference: NCI_CDISC:SDTM-LBTEST
database_cross_reference: NCI_CDISC:SDTM-LBTESTCD
database_cross_reference: NCI_CRCH:C808
database_cross_reference: NCI_DCP:02185
database_cross_reference: NCI_DTP:NSC0033298
database_cross_reference: NCI_FDA:TLM2976OFR
database_cross_reference: NCI_NCI-GLOSS:CDR0000556406
database_cross_reference: NCI_NCI-GLOSS:CDR0000629161
database_cross_reference: NDDF:001059
database_cross_reference: NDFRT:N0000005897
database_cross_reference: NDFRT:N0000146013
database_cross_reference: NDFRT:N0000146139
database_cross_reference: PDQ:CDR0000038330
database_cross_reference: RCD:X80RU
database_cross_reference: RCD:in3..
database_cross_reference: RXNORM:9346
database_cross_reference: SNM:E-8784
database_cross_reference: SNM:F-16220
database_cross_reference: SNMI:C-A4450
database_cross_reference: SNMI:F-BB320
database_cross_reference: SNOMEDCT_US:13235001
database_cross_reference: SNOMEDCT_US:329260009
database_cross_reference: SNOMEDCT_US:88306001
database_cross_reference: VANDF:4017633
database_cross_reference: VANDF:4017778

Flavin Mononucleotide
type: Class
subclass of: PMO:00024098
MCID: MC00005224
PMOID: PMO:00017769
Subclass_of: Ribonucleotides
Synonym: 5'-Monophosphate, Riboflavin
Synonym: 5'-Phosphate, Riboflavin
Synonym: FLAVIN MONONUCLEOTIDE
Synonym: FMN
Synonym: Flavin Mononucleotide [Chemical/Ingredient]
Synonym: Flavin mononucleotide
Synonym: Mononucleotide, Flavin
Synonym: Mononucleotide, Riboflavin
Synonym: RIBOFLAVIN PHOSPHATE
Synonym: Riboflavin 5' Monophosphate
Tree Number: T6.11.4.7.3
database_cross_reference: CHV:0000005141
database_cross_reference: CSP:1153-3183
database_cross_reference: DRUGBANK:DB03247
database_cross_reference: LNC:LP70671-0
database_cross_reference: LNC:MTHU030115
database_cross_reference: MMSL:31895
database_cross_reference: MSH:D005486
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7N464URE7E
database_cross_reference: NCI:C61925
database_cross_reference: NCI_FDA:7N464URE7E
database_cross_reference: NDDF:014666
database_cross_reference: NDFRT:N0000146134
database_cross_reference: NDFRT:N0000171223
database_cross_reference: RXNORM:4509
database_cross_reference: SNM:F-16230
database_cross_reference: SNMI:F-BB330
database_cross_reference: SNOMEDCT_US:53499005
database_cross_reference: VANDF:4017770

Pterins
type: Class
subclass of: PMO:00024379
MCID: MC00010889
PMOID: PMO:00017770
Subclass_of: Pigments, Biological
Synonym: Pterins (substance)
Synonym: Pterins [Chemical/Ingredient]
Synonym: Pterins, NOS
Synonym: pterin
Synonym: pterins
Tree Number: T6.13.7.15
database_cross_reference: CHV:0000010354
database_cross_reference: CSP:2486-5948
database_cross_reference: LNC:LP204179-8
database_cross_reference: MSH:D011622
database_cross_reference: NDFRT:N0000008033
database_cross_reference: SNMI:F-62B50
database_cross_reference: SNOMEDCT_US:22078005

Biopterin
type: Class
subclass of: Coenzymes
MCID: MC00001761
PMOID: PMO:00017773
Subclass_of: Coenzymes
Synonym: 2-Amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone
Synonym: 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-, (S-(R*,S*))-
Synonym: Biopterin [Chemical/Ingredient]
Synonym: Biopterin analyte
Synonym: Biopterin analyte (substance)
Synonym: biopterin
Tree Number: T6.7.1.1
database_cross_reference: CHV:0000001912
database_cross_reference: DRUGBANK:DB03886
database_cross_reference: LNC:LP15450-7
database_cross_reference: LNC:LP31997-7
database_cross_reference: LNC:MTHU008873
database_cross_reference: MSH:D001708
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168397
database_cross_reference: RCD:X80Gn
database_cross_reference: RCD:Xa87W
database_cross_reference: SNMI:F-62B90
database_cross_reference: SNOMEDCT_US:301892007
database_cross_reference: SNOMEDCT_US:36326009

Neopterin
type: Class
subclass of: Biopterin
MCID: MC00033050
PMOID: PMO:00017774
Subclass_of: Biopterin
Synonym: 2-Amino-6-(1,2,3-Trihydroxypropyl)-4(3H)-Pteridinone
Synonym: 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone
Synonym: 4(1H)-Pteridinone, 2-Amino-6-(1,2,3-Trihydroxypropyl)-
Synonym: AMINOTRIHYDROXYPROPYL PTERIDINONE 002 006 001 001 003 004 003 H
Synonym: D-monapterin
Synonym: D-threo-monapterin
Synonym: D-threo-neopterin
Synonym: Neopterin (substance)
Synonym: Neopterin D-threo-form
Synonym: Neopterin [Chemical/Ingredient]
Tree Number: T6.7.1.1.1
database_cross_reference: CHV:0000014484
database_cross_reference: DRUGBANK:DB02385
database_cross_reference: LCH_NW:sh91004709
database_cross_reference: LNC:LP16216-1
database_cross_reference: LNC:MTHU015942
database_cross_reference: MSH:D019798
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C129010
database_cross_reference: NDFRT:N0000168398
database_cross_reference: RCD:X80Gu
database_cross_reference: SNMI:F-62BA0
database_cross_reference: SNOMEDCT_US:102694005

Tetrahydrofolates
type: Class
subclass of: Coenzymes
MCID: MC00012657
PMOID: PMO:00017777
Subclass_of: Coenzymes
Synonym: Tetrahydrofolates [Chemical/Ingredient]
Tree Number: T6.7.1.10
database_cross_reference: MSH:D013763
database_cross_reference: NDFRT:N0000008225

Formyltetrahydrofolates
type: Class
subclass of: Tetrahydrofolates
MCID: MC00005278
PMOID: PMO:00017778
Subclass_of: Tetrahydrofolates
Synonym: Acids, Formyltetrahydrofolic
Synonym: Formyltetrahydrofolates [Chemical/Ingredient]
Synonym: Formyltetrahydrofolic Acids
Synonym: formyltetrahydrofolate
Synonym: formyltetrahydrofolates
Tree Number: T6.7.1.10.1
database_cross_reference: AOD:0000018229
database_cross_reference: CSP:3147-1098
database_cross_reference: MSH:D005575
database_cross_reference: NDFRT:N0000007610

Xanthopterin
type: Class
subclass of: Pterins
MCID: MC00013756
PMOID: PMO:00017781
Subclass_of: Pterins
Synonym: 4,6-Pteridinedione, 2-amino-1,5-dihydro-
Synonym: Uropterin
Synonym: Xanthopterin (substance)
Synonym: Xanthopterin [Chemical/Ingredient]
Tree Number: T6.13.7.15.1
database_cross_reference: LNC:LP200577-7
database_cross_reference: LNC:MTHU051401
database_cross_reference: MSH:D014976
database_cross_reference: NDFRT:N0000171235
database_cross_reference: SNMI:F-62B60
database_cross_reference: SNOMEDCT_US:23904000

Purines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00010930
PMOID: PMO:00017783
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: 1H-Purine
Synonym: PURINE
Synonym: Purine
Synonym: Purine (substance)
Synonym: Purine, NOS
Synonym: Purines [Chemical/Ingredient]
Synonym: beta-Purine
Synonym: purine
Synonym: purines
Tree Number: T6.3.1.1.16
database_cross_reference: AOD:0000001924
database_cross_reference: CHV:0000010417
database_cross_reference: CSP:2503-2645
database_cross_reference: FMA:82772
database_cross_reference: LCH:U003955
database_cross_reference: LCH_NW:sh85109190
database_cross_reference: MSH:D011687
database_cross_reference: MTH:U002202
database_cross_reference: NCI:C786
database_cross_reference: NCI_FDA:W60KTZ3IZY
database_cross_reference: NDFRT:N0000008065
database_cross_reference: SNMI:F-65500
database_cross_reference: SNOMEDCT_US:45386002

Purine Nucleosides
type: Class
subclass of: PMO:00020982
MCID: MC00010927
PMOID: PMO:00017792
Subclass_of: Nucleosides
Synonym: Nucleosides, Purine
Synonym: Purine Nucleosides [Chemical/Ingredient]
Synonym: Purine nucleoside
Synonym: Purine nucleoside (substance)
Synonym: purine nucleoside
Synonym: purine nucleosides
Tree Number: T6.11.3.3
database_cross_reference: AOD:0000020651
database_cross_reference: CSP:2502-7026
database_cross_reference: DRUGBANK:DB04440
database_cross_reference: MSH:D011684
database_cross_reference: NDFRT:N0000008061
database_cross_reference: RCD:Xa9po
database_cross_reference: SNOMEDCT_US:304080007

Adenosine
type: Class
subclass of: Purine Nucleosides
subclass of: PMO:00024070
MCID: MC00000354
PMOID: PMO:00017793
Subclass_of: Purine Nucleosides
Subclass_of: Ribonucleosides
Synonym: (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Synonym: 6-Amino-9-beta-D-ribofuranosyl-9H-purine
Synonym: 9-beta-D-Ribofuranosidoadenine
Synonym: 9-beta-D-Ribofuranosyl-9H-purin-6-amine
Synonym: A.H.C Real Eye For Face
Synonym: A.H.C. Collagen Cream
Synonym: A.H.C. Collagen Toner
Synonym: A.H.c Cotton 100 Mask Multi Peptide
Synonym: A.H.c Cotton 100 Mask Skin Ceramide
Synonym: A.H.c Cotton 100 Mask Soy Isoflavone
Tree Number: T6.11.3.3.1
Tree Number: T6.11.3.5.1
database_cross_reference: AOD:0000020652
database_cross_reference: ATC:C01EB10
database_cross_reference: CHV:0000000720
database_cross_reference: CSP:2502-7256
database_cross_reference: DRUGBANK:DB00640
database_cross_reference: LCH:U000068
database_cross_reference: LCH_NW:sh85000846
database_cross_reference: LNC:LP208669-4
database_cross_reference: LNC:LP35677-1
database_cross_reference: LNC:LP35683-9
database_cross_reference: LNC:LP35974-2
database_cross_reference: LNC:MTHU047710
database_cross_reference: MEDCIN:48814
database_cross_reference: MMSL:4135
database_cross_reference: MMSL:57772
database_cross_reference: MMSL:d00164
database_cross_reference: MSH:D000241
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:K72T3FS567
database_cross_reference: NCI:C207
database_cross_reference: NCI_DTP:NSC0007652
database_cross_reference: NCI_DTP:NSC0627048
database_cross_reference: NCI_FDA:K72T3FS567
database_cross_reference: NDDF:003603
database_cross_reference: NDDF:004537
database_cross_reference: NDDF:004813
database_cross_reference: NDFRT:N0000007355
database_cross_reference: NDFRT:N0000147627
database_cross_reference: PSY:00820
database_cross_reference: RCD:XM0l8
database_cross_reference: RCD:bcc..
database_cross_reference: RXNORM:296
database_cross_reference: SNM:F-15330
database_cross_reference: SNMI:F-65530
database_cross_reference: SNOMEDCT_US:108502004
database_cross_reference: SNOMEDCT_US:35431001
database_cross_reference: SNOMEDCT_US:371177000
database_cross_reference: SNOMEDCT_US:386857003
database_cross_reference: SNOMEDCT_US:391720004
database_cross_reference: VANDF:4019507

Deoxyadenosines
type: Class
subclass of: PMO:00024068
MCID: MC00003672
PMOID: PMO:00017794
Subclass_of: Deoxyribonucleosides
Synonym: Adenine Deoxyribonucleosides
Synonym: Adenylyldeoxyribonucleosides
Synonym: Deoxyadenosine Derivatives
Synonym: Deoxyadenosines [Chemical/Ingredient]
Synonym: Deoxyribonucleosides, Adenine
Synonym: Derivatives, Deoxyadenosine
Tree Number: T6.11.3.2.1
database_cross_reference: MSH:D003839
database_cross_reference: NDFRT:N0000007761

Vidarabine
type: Class
subclass of: PMO:00024067
MCID: MC00013555
PMOID: PMO:00017798
Subclass_of: Arabinonucleosides
Synonym: 2-(6-AMINO-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Synonym: 9 beta Arabinofuranosyladenine
Synonym: 9 beta D Arabinofuranosyladenine
Synonym: 9-Beta-D-arabinofuranosyl-9H-purine-6-amine Monohydrate
Synonym: 9-Beta-D-arabinofuranosyladenine Monohydrate
Synonym: 9-beta-Arabinofuranosyladenine
Synonym: 9-beta-D-Arabinofuranosyl-9H-purin-6-amine
Synonym: 9-beta-D-Arabinofuranosyladenine
Synonym: 9-beta-D-arabinofuranosyl-adenine
Synonym: 9-beta-D-arabinofuranosyladenine
Tree Number: T6.11.3.1.3
database_cross_reference: ATC:J05AB03
database_cross_reference: ATC:S01AD06
database_cross_reference: CHV:0000012991
database_cross_reference: CSP:2502-7151
database_cross_reference: CSP:4005-0017
database_cross_reference: DRUGBANK:DB00194
database_cross_reference: MEDCIN:40354
database_cross_reference: MEDCIN:41321
database_cross_reference: MMSL:5673
database_cross_reference: MSH:D014740
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C929
database_cross_reference: NCI_DTP:NSC0247519
database_cross_reference: NCI_DTP:NSC0404241
database_cross_reference: NCI_FDA:FA2DM6879K
database_cross_reference: NDDF:003014
database_cross_reference: NDFRT:N0000007186
database_cross_reference: NDFRT:N0000146963
database_cross_reference: PDQ:CDR0000039150
database_cross_reference: RCD:ei4..
database_cross_reference: RCD:x01Iz
database_cross_reference: RXNORM:11194
database_cross_reference: SNM:E-7356
database_cross_reference: SNMI:C-55B50
database_cross_reference: SNOMEDCT_US:324761005
database_cross_reference: SNOMEDCT_US:37306000
database_cross_reference: SNOMEDCT_US:373759007
database_cross_reference: VANDF:4018650

Guanosine
type: Class
subclass of: Purine Nucleosides
subclass of: PMO:00024070
MCID: MC00005872
PMOID: PMO:00017801
Subclass_of: Purine Nucleosides
Subclass_of: Ribonucleosides
Synonym: 2(3H)-imino-9-β-D-ribofuranosyl-9H-purin-6(1H)-one
Synonym: 2-Amino-9-Beta-D-Ribofuranosyl-9H-Purine-6(1H)-One
Synonym: 2-amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one
Synonym: 9-β-D-ribofuranosyl-guanine
Synonym: GUANOSINE
Synonym: Guanine riboside
Synonym: Guanine-9-β-D-ribofuranoside
Synonym: Guanosin
Synonym: Guanosine (substance)
Synonym: Guanosine [Chemical/Ingredient]
Tree Number: T6.11.3.3.2
Tree Number: T6.11.3.5.5
database_cross_reference: AOD:0000020654
database_cross_reference: CHV:0000005730
database_cross_reference: CSP:2502-8151
database_cross_reference: DRUGBANK:DB02857
database_cross_reference: LNC:LP199590-3
database_cross_reference: LNC:MTHU051171
database_cross_reference: MSH:D006151
database_cross_reference: MTHSPL:12133JR80S
database_cross_reference: NCI:C533
database_cross_reference: NCI_FDA:12133JR80S
database_cross_reference: NDFRT:N0000170646
database_cross_reference: PSY:21929
database_cross_reference: RCD:X80Lt
database_cross_reference: RXNORM:1591890
database_cross_reference: SNM:F-15490
database_cross_reference: SNMI:F-65690
database_cross_reference: SNOMEDCT_US:529003

Deoxyguanosine
type: Class
subclass of: PMO:00024068
MCID: MC00003684
PMOID: PMO:00017802
Subclass_of: Deoxyribonucleosides
Synonym: 2'-Deoxyguanosine
Synonym: Deoxyguanosine (substance)
Synonym: Deoxyguanosine [Chemical/Ingredient]
Synonym: Guanosine, 2'-deoxy-
Synonym: deoxyguanosine
Tree Number: T6.11.3.2.3
database_cross_reference: CSP:2502-8026
database_cross_reference: LNC:LP99926-5
database_cross_reference: LNC:MTHU047921
database_cross_reference: MSH:D003849
database_cross_reference: NCI:C421
database_cross_reference: NCI_DTP:NSC0022837
database_cross_reference: NDFRT:N0000170629
database_cross_reference: SNOMEDCT_US:709843006

Inosine
type: Class
subclass of: Purine Nucleosides
subclass of: PMO:00024070
MCID: MC00006872
PMOID: PMO:00017804
Subclass_of: Purine Nucleosides
Subclass_of: Ribonucleosides
Synonym: Catacol
Synonym: Hypoxanthosine
Synonym: INO
Synonym: Inosina
Synonym: Inosine (substance)
Synonym: Inosine [Chemical/Ingredient]
Synonym: Inosinum
Synonym: Lumiclar
Synonym: Oxiamin
Synonym: Rejuvesol
Tree Number: T6.11.3.3.3
Tree Number: T6.11.3.5.6
database_cross_reference: AOD:0000020655
database_cross_reference: ATC:D06BB05
database_cross_reference: ATC:G01AX02
database_cross_reference: ATC:S01XA10
database_cross_reference: CHV:0000006750
database_cross_reference: CSP:2502-8401
database_cross_reference: DRUGBANK:DB04335
database_cross_reference: LCH_NW:sh90000261
database_cross_reference: LNC:LP15666-8
database_cross_reference: LNC:MTHU012014
database_cross_reference: MSH:D007288
database_cross_reference: MTHSPL:5A614L51CT
database_cross_reference: NDDF:003901
database_cross_reference: NDFRT:N0000008090
database_cross_reference: RCD:X80Lv
database_cross_reference: RXNORM:1483575
database_cross_reference: SNMI:F-61048
database_cross_reference: SNOMEDCT_US:102640000

Tubercidin
type: Class
subclass of: Purine Nucleosides
subclass of: PMO:00024070
MCID: MC00013184
PMOID: PMO:00017806
Subclass_of: Purine Nucleosides
Subclass_of: Ribonucleosides
Synonym: 4-Amino-7 beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine
Synonym: 4-Amino-7-.beta.-D-ribofuranosyl-7H-pyrrolo[2, 3-d]pyrimidine
Synonym: 4-Amino-7.beta.-D-ribofuranosyl-7H-pyrrolo(2, 3-d)pyrimidine
Synonym: 4-amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine
Synonym: 7 Deazaadenosine
Synonym: 7-Deazaadenosine
Synonym: 7-Deazadenosine
Synonym: 7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Synonym: 7-deazaadenosine
Synonym: 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 7-beta-D-ribofuranosyl-
Tree Number: T6.11.3.3.4
Tree Number: T6.11.3.5.10
database_cross_reference: CHV:0000012626
database_cross_reference: CSP:0210-1974
database_cross_reference: DRUGBANK:DB03172
database_cross_reference: MSH:D014372
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C911
database_cross_reference: NCI_DTP:NSC0056408
database_cross_reference: NCI_FDA:M351LCX45Y
database_cross_reference: NDFRT:N0000170636
database_cross_reference: PDQ:CDR0000039728

Purine Nucleotides
type: Class
subclass of: PMO:00020983
MCID: MC00010928
PMOID: PMO:00017807
Subclass_of: Nucleotides
Synonym: Nucleotides, Purine
Synonym: Purine Nucleotides [Chemical/Ingredient]
Synonym: Purine nucleotide
Synonym: Purine nucleotide (substance)
Synonym: Purine nucleotides
Synonym: purine nucleotide
Synonym: purine nucleotides
Tree Number: T6.11.4.5
database_cross_reference: AOD:0000020671
database_cross_reference: CSP:2502-8899
database_cross_reference: LCH:U003954
database_cross_reference: LCH_NW:sh85109188
database_cross_reference: MSH:D011685
database_cross_reference: NDFRT:N0000008062
database_cross_reference: RCD:Xa9pp
database_cross_reference: SNOMEDCT_US:304081006

Adenine Nucleotides
type: Class
subclass of: Purine Nucleotides
subclass of: PMO:00024098
MCID: MC00000340
PMOID: PMO:00017808
Subclass_of: Purine Nucleotides
Subclass_of: Ribonucleotides
Synonym: Adenine Nucleotides [Chemical/Ingredient]
Synonym: Adenine nucleotides
Synonym: Adenosine Phosphates
Synonym: Nucleotides, Adenine
Synonym: Phosphates, Adenosine
Synonym: adenine nucleotide
Synonym: adenine nucleotides
Synonym: adenosine 5 monophosphate
Synonym: adenosine phosphate
Tree Number: T6.11.4.5.1
Tree Number: T6.11.4.7.1
database_cross_reference: AOD:0000020673
database_cross_reference: CHV:0000000706
database_cross_reference: CSP:2502-9086
database_cross_reference: LCH_NW:sh91003165
database_cross_reference: MSH:D000227
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007310

Cyclic AMP
type: Class
subclass of: PMO:00024077
MCID: MC00000360
PMOID: PMO:00017809
Subclass_of: Nucleotides, Cyclic
Synonym: 3',5'-Cyclic AMP
Synonym: 3',5'-Monophosphate, Adenosine Cyclic
Synonym: 3'-5'-cyclic adenosine monophosphate
Synonym: 3'5'-cyclic ester of AMP
Synonym: ADENOSINE CYCLIC 3',5'-PHOSPHATE
Synonym: ADENOSINE CYCLIC MONOPHOSPHATE 03 05
Synonym: ADENOSINE CYCLIC PHOSPHATE
Synonym: AMP, Cyclic
Synonym: Adenosine Cyclic 3',5' Monophosphate
Synonym: Adenosine Cyclic 3',5'-(Hydrogen Phosphate)
Tree Number: T6.11.4.3.1
database_cross_reference: AOD:0000020675
database_cross_reference: AOD:0000029017
database_cross_reference: AOD:0000029018
database_cross_reference: CHV:0000000721
database_cross_reference: CSP:2502-9637
database_cross_reference: DRUGBANK:DB02527
database_cross_reference: LNC:LP15327-7
database_cross_reference: LNC:MTHU004902
database_cross_reference: MSH:D000242
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:E0399OZS9N
database_cross_reference: NCI:C208
database_cross_reference: NCI_DCP:00446
database_cross_reference: NCI_DTP:NSC0094017
database_cross_reference: NCI_FDA:E0399OZS9N
database_cross_reference: NDFRT:N0000170819
database_cross_reference: PSY:12875
database_cross_reference: RCD:X80N5
database_cross_reference: RXNORM:1314330
database_cross_reference: SNM:F-15910
database_cross_reference: SNMI:F-65980
database_cross_reference: SNOMEDCT_US:84835006

Vidarabine Phosphate
type: Class
subclass of: PMO:00024075
MCID: MC00001198
PMOID: PMO:00017823
Subclass_of: Arabinonucleotides
Synonym: 9-(5-O-Phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
Synonym: 9H-Purin-6-amine, 9-(5-O-phosphono-beta-D-arabinofuranosyl)-
Synonym: Adenine Arabinoside Monophosphate
Synonym: Ara AMP
Synonym: Ara-AMP
Synonym: Arabinofuranosyladenine Monophosphate
Synonym: Monophosphate, Adenine Arabinoside
Synonym: Monophosphate, Arabinofuranosyladenine
Synonym: Monophosphate, Vidarabine
Synonym: Phosphate, Vidarabine
Tree Number: T6.11.4.1.1
database_cross_reference: MSH:D001084
database_cross_reference: NCI:C90789
database_cross_reference: NCI_FDA:106XV160TZ
database_cross_reference: NDDF:005669
database_cross_reference: NDFRT:N0000011203

Coenzyme A
type: Class
subclass of: Coenzymes
MCID: MC00003040
PMOID: PMO:00017824
Subclass_of: Coenzymes
Synonym: 3'-phosphoadenosine-(5')diphospho(4')pantatheine
Synonym: COENZYME A
Synonym: COENZYME A AA
Synonym: CoA
Synonym: CoA (chemical)
Synonym: Coenzyme A (substance)
Synonym: Coenzyme A [Chemical/Ingredient]
Synonym: coA
Synonym: coa
Synonym: coenzyme A
Tree Number: T6.7.1.4
database_cross_reference: AOD:0000018583
database_cross_reference: AOD:0000028322
database_cross_reference: CHV:0000003128
database_cross_reference: CSP:0704-2647
database_cross_reference: DRUGBANK:DB01992
database_cross_reference: MSH:D003065
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:SAA04E81UX
database_cross_reference: NCI:C384
database_cross_reference: NCI_DTP:NSC0020274
database_cross_reference: NCI_FDA:SAA04E81UX
database_cross_reference: NDDF:007407
database_cross_reference: NDFRT:N0000170824
database_cross_reference: RXNORM:1314344
database_cross_reference: SNM:F-16350
database_cross_reference: SNOMEDCT_US:129914004

Acyl Coenzyme A
type: Class
subclass of: Coenzyme A
MCID: MC00000329
PMOID: PMO:00017825
Subclass_of: Coenzyme A
Synonym: Acyl CoA
Synonym: Acyl CoA, Fatty
Synonym: Acyl CoA, Long-Chain
Synonym: Acyl Coenzyme A [Chemical/Ingredient]
Synonym: Acyl coenzyme A
Synonym: Acyl coenzyme A (substance)
Synonym: CoA, Acyl
Synonym: CoA, Fatty Acyl
Synonym: CoA, Long-Chain Acyl
Synonym: Coenzyme A, Acyl
Tree Number: T6.7.1.4.1
database_cross_reference: AOD:0000018586
database_cross_reference: AOD:0000028323
database_cross_reference: CHV:0000000698
database_cross_reference: CSP:0704-3181
database_cross_reference: MSH:D000214
database_cross_reference: NDFRT:N0000170825
database_cross_reference: SNOMEDCT_US:129917006

Deoxyadenine Nucleotides
type: Class
subclass of: PMO:00024076
MCID: MC00003671
PMOID: PMO:00017829
Subclass_of: Deoxyribonucleotides
Synonym: Deoxyadenine Nucleotides [Chemical/Ingredient]
Synonym: Deoxyadenosine Phosphates
Synonym: Nucleotides, Deoxyadenine
Synonym: Phosphates, Deoxyadenosine
Tree Number: T6.11.4.2.1
database_cross_reference: MSH:D003838
database_cross_reference: NDFRT:N0000170857

NAD
type: Class
subclass of: Coenzymes
MCID: MC00008618
PMOID: PMO:00017830
Subclass_of: Coenzymes
Synonym: 3-Carbamoyl-1-Beta-D-Ribofuranosylpyridinium Hydroxide 5'-5'-Ester with Adenosine 5'-(Trihydrogen Pyrophosphate) Inner Salt
Synonym: 3-Carbamoyl-1-Beta-D-Ribofuranosylpyridinium Hydroxide, 5'-Ester with Adenosine 5'-Pyrophosphate, Inner Salt
Synonym: Adenine Dinucleotide, Dihydronicotinamide
Synonym: Adenosine 5'-(Trihydrogen Diphosphate), 5'-5'-Ester with 3-(Aminocarbonyl)-1-Beta-D-Ribofuranosylpyridinium, Hydroxide, Inner Salt
Synonym: Adenosine 5'-(trihydrogen diphosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt
Synonym: Beta-NAD
Synonym: COENZYME A A 01
Synonym: Co-I
Synonym: Codehydrogenase I
Synonym: Coenzyme I
Tree Number: T6.7.1.7
database_cross_reference: AOD:0000020678
database_cross_reference: AOD:0000029023
database_cross_reference: CHV:0000008457
database_cross_reference: CSP:2510-6440
database_cross_reference: MSH:D009243
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:0U46U6E8UK
database_cross_reference: NCI:C675
database_cross_reference: NCI:C87339
database_cross_reference: NCI_DTP:NSC0020272
database_cross_reference: NCI_FDA:0U46U6E8UK
database_cross_reference: NDDF:008958
database_cross_reference: NDFRT:N0000170823
database_cross_reference: RXNORM:1044975
database_cross_reference: SNM:F-15880
database_cross_reference: SNOMEDCT_US:131143000

NADP
type: Class
subclass of: Coenzymes
MCID: MC00008628
PMOID: PMO:00017831
Subclass_of: Coenzymes
Synonym: Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt
Synonym: COENZYME A A 02
Synonym: Coenzyme II
Synonym: Dinucleotide Phosphate, Nicotinamide-Adenine
Synonym: NAD phosphate
Synonym: NAD(H) phosphate
Synonym: NADH phosphate
Synonym: NADP [Chemical/Ingredient]
Synonym: NADPH
Synonym: Nicotinamide Adenine Dinucleotide Phosphate
Tree Number: T6.7.1.8
database_cross_reference: AOD:0000020679
database_cross_reference: AOD:0000029026
database_cross_reference: AOD:0000029027
database_cross_reference: AOD:0000029030
database_cross_reference: CHV:0000008460
database_cross_reference: CSP:2510-7188
database_cross_reference: MSH:D009249
database_cross_reference: MTH:U002097
database_cross_reference: NCI:C676
database_cross_reference: NDFRT:N0000170829
database_cross_reference: SNM:F-15900
database_cross_reference: SNOMEDCT_US:131144006

Guanine Nucleotides
type: Class
subclass of: Purine Nucleotides
subclass of: PMO:00024098
MCID: MC00005871
PMOID: PMO:00017833
Subclass_of: Purine Nucleotides
Subclass_of: Ribonucleotides
Synonym: Guanine Nucleotides [Chemical/Ingredient]
Synonym: Guanosine Phosphates
Synonym: Nucleotides, Guanine
Synonym: Phosphates, Guanosine
Synonym: guanine nucleotide
Synonym: guanine nucleotides
Tree Number: T6.11.4.5.2
Tree Number: T6.11.4.7.4
database_cross_reference: AOD:0000020681
database_cross_reference: CSP:2503-0386
database_cross_reference: MSH:D006150
database_cross_reference: NDFRT:N0000170838

Deoxyguanine Nucleotides
type: Class
subclass of: PMO:00024076
MCID: MC00003683
PMOID: PMO:00017834
Subclass_of: Deoxyribonucleotides
Synonym: Deoxyguanine Nucleotides [Chemical/Ingredient]
Synonym: Deoxyguanosine Phosphates
Synonym: Nucleotides, Deoxyguanine
Synonym: Phosphates, Deoxyguanosine
Tree Number: T6.11.4.2.3
database_cross_reference: MSH:D003848
database_cross_reference: NDFRT:N0000170859

Cyclic GMP
type: Class
subclass of: PMO:00024077
MCID: MC00005873
PMOID: PMO:00017835
Subclass_of: Nucleotides, Cyclic
Synonym: 3',5'-Monophosphate, Guanosine Cyclic
Synonym: CYCL GMP
Synonym: Cyclic 3',5'-Monophosphate, Guanosine
Synonym: Cyclic GMP [Chemical/Ingredient]
Synonym: Cyclic Guanosine Monophosphate
Synonym: Cyclic Monophosphate, Guanosine
Synonym: Cyclic guanosine monophosphate
Synonym: Cyclic guanosine monophosphate (substance)
Synonym: Cyclic-3',5'-Monophosphate, Guanosine
Synonym: GMP, Cyclic
Tree Number: T6.11.4.3.3
database_cross_reference: AOD:0000020683
database_cross_reference: AOD:0000029032
database_cross_reference: AOD:0000029033
database_cross_reference: CHV:0000005731
database_cross_reference: CSP:2503-0807
database_cross_reference: DRUGBANK:DB02315
database_cross_reference: LNC:LP15627-0
database_cross_reference: LNC:MTHU011602
database_cross_reference: MSH:D006152
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C534
database_cross_reference: NCI_DCP:05879
database_cross_reference: NCI_FDA:H2D2X058MU
database_cross_reference: NDFRT:N0000170850
database_cross_reference: SNM:F-15920
database_cross_reference: SNMI:F-65990
database_cross_reference: SNOMEDCT_US:42204005

Inosine Nucleotides
type: Class
subclass of: Purine Nucleotides
subclass of: PMO:00024098
MCID: MC00006876
PMOID: PMO:00017848
Subclass_of: Purine Nucleotides
Subclass_of: Ribonucleotides
Synonym: Inosine Nucleotides [Chemical/Ingredient]
Synonym: Inosine Phosphates
Synonym: Nucleotides, Inosine
Synonym: Phosphates, Inosine
Tree Number: T6.11.4.5.3
Tree Number: T6.11.4.7.5
database_cross_reference: MSH:D007292
database_cross_reference: NDFRT:N0000170833

Cyclic IMP
type: Class
subclass of: PMO:00024077
MCID: MC00006873
PMOID: PMO:00017849
Subclass_of: Nucleotides, Cyclic
Synonym: CYCL IMP
Synonym: Cyclic 3',5'-Monophosphate, Inosine
Synonym: Cyclic IMP [Chemical/Ingredient]
Synonym: Cyclic Monophosphate, Inosine
Synonym: Cyclic-3',5'-Monophosphate, Inosine
Synonym: IMP, Cyclic
Synonym: INOSINE CYCLIC MONOPHOSPHATE 03 05
Synonym: Inosine Cyclic 3',5' Monophosphate
Synonym: Inosine Cyclic 3',5'-Monophosphate
Synonym: Inosine Cyclic Monophosphate
Tree Number: T6.11.4.3.4
database_cross_reference: MSH:D007289
database_cross_reference: NDFRT:N0000170837

Xanthines
type: Class
subclass of: Alkaloids
MCID: MC00013750
PMOID: PMO:00017860
Subclass_of: Alkaloids
Synonym: Xanthine
Synonym: Xanthine product
Synonym: Xanthines [Chemical/Ingredient]
Synonym: xanthine
Synonym: xanthines
Synonym: xanthines (medication)
Tree Number: T6.3.3.22
database_cross_reference: AOD:0000018473
database_cross_reference: CHV:0000013224
database_cross_reference: DRUGBANK:DB02134
database_cross_reference: MEDCIN:41483
database_cross_reference: MSH:D014970
database_cross_reference: MTH:U002366
database_cross_reference: NDFRT:N0000008118
database_cross_reference: RCD:x01Ei

Caffeine
type: Class
subclass of: Xanthines
MCID: MC00002093
PMOID: PMO:00017861
Subclass_of: Xanthines
Synonym: 217
Synonym: (extra Strength) Acetaminophen, Caffeine & 8mg Codeine Phosphate Caplets
Synonym: 1,3,7-Trimethylxanthine
Synonym: 1,3,7-trimethyl-2,6-dioxopurine
Synonym: 1,3,7-trimethylpurine-2,6-dione
Synonym: 1,3,7-trimethylxanthine
Synonym: 1-methyltheobromine
Synonym: 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
Synonym: 217 Strong Tab
Synonym: 222 Tablets
Tree Number: T6.3.3.22.1
database_cross_reference: AOD:0000000656
database_cross_reference: ATC:N06BC01
database_cross_reference: CCPSS:0060596
database_cross_reference: CHV:0000002282
database_cross_reference: CSP:2503-3751
database_cross_reference: DRUGBANK:DB00201
database_cross_reference: LCH:U000737
database_cross_reference: LCH_NW:sh85018686
database_cross_reference: LNC:LP16057-9
database_cross_reference: LNC:MTHU012263
database_cross_reference: MEDCIN:197675
database_cross_reference: MEDCIN:199594
database_cross_reference: MEDLINEPLUS:1456
database_cross_reference: MMSL:4318
database_cross_reference: MMSL:4939
database_cross_reference: MMSL:d00801
database_cross_reference: MSH:D002110
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:3G6A5W338E
database_cross_reference: NCI:C328
database_cross_reference: NCI_CRCH:C328
database_cross_reference: NCI_DCP:00344
database_cross_reference: NCI_DTP:NSC0005036
database_cross_reference: NCI_FDA:3G6A5W338E
database_cross_reference: NCI_NCI-GLOSS:CDR0000454809
database_cross_reference: NDDF:000600
database_cross_reference: NDFRT:N0000006506
database_cross_reference: NDFRT:N0000145919
database_cross_reference: PDQ:CDR0000040817
database_cross_reference: PSY:07210
database_cross_reference: RCD:X7953
database_cross_reference: RCD:c44..
database_cross_reference: RXNORM:1886
database_cross_reference: SNM:E-7722
database_cross_reference: SNMI:C-65550
database_cross_reference: SNOMEDCT_US:255641001
database_cross_reference: SNOMEDCT_US:91107009
database_cross_reference: VANDF:4017537

Theobromine
type: Class
subclass of: Xanthines
MCID: MC00012692
PMOID: PMO:00017862
Subclass_of: Xanthines
Synonym: 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-
Synonym: 3,7-Dihydro-3,7-Dimethyl-1H-Purine-2,6-Dione
Synonym: 3,7-Dimethylpurine-2,6-dione
Synonym: 3,7-Dimethylxanthine
Synonym: 3,7-dihydro-3,7-Dimethyl-1H-purine-2,6-dione
Synonym: THEOBROMINE
Synonym: Theobromin
Synonym: Theobromine (substance)
Synonym: Theobromine [Chemical/Ingredient]
Synonym: theobromine
Tree Number: T6.3.3.22.2
database_cross_reference: ATC:C03BD01
database_cross_reference: ATC:R03DA07
database_cross_reference: CHV:0000012156
database_cross_reference: CSP:2503-3844
database_cross_reference: DRUGBANK:DB01412
database_cross_reference: LNC:LP18053-6
database_cross_reference: LNC:MTHU003047
database_cross_reference: MEDCIN:40634
database_cross_reference: MSH:D013805
database_cross_reference: MTHSPL:OBD445WZ5P
database_cross_reference: NCI:C87684
database_cross_reference: NCI_FDA:OBD445WZ5P
database_cross_reference: NDDF:000611
database_cross_reference: NDFRT:N0000007074
database_cross_reference: NDFRT:N0000147383
database_cross_reference: RCD:Ub09a
database_cross_reference: RXNORM:10437
database_cross_reference: SNM:E-8915
database_cross_reference: SNMI:C-30333
database_cross_reference: SNOMEDCT_US:75371004
database_cross_reference: VANDF:4019132

Theophylline
type: Class
subclass of: Xanthines
MCID: MC00012693
PMOID: PMO:00017864
Subclass_of: Xanthines
Synonym: 1,3 Dimethylxanthine
Synonym: 1,3-Dimethylxanthine
Synonym: 1,3-dimethyl-7H-purine-2,6-dione
Synonym: 1,3-dimethylxanthine
Synonym: 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-
Synonym: 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
Synonym: Apo-theo ER
Synonym: Apo-theo-LA Srt 100mg
Synonym: Apo-theo-LA Srt 200mg
Synonym: Apo-theo-LA Srt 300mg
Tree Number: T6.3.3.22.3
database_cross_reference: AOD:0000000658
database_cross_reference: ATC:R03DA04
database_cross_reference: CHV:0000012157
database_cross_reference: CSP:2503-3937
database_cross_reference: DRUGBANK:DB00277
database_cross_reference: LCH:U004643
database_cross_reference: LCH_NW:sh85134710
database_cross_reference: LNC:LP16288-0
database_cross_reference: LNC:MTHU004269
database_cross_reference: MEDCIN:41479
database_cross_reference: MMSL:2086
database_cross_reference: MMSL:4173
database_cross_reference: MMSL:5563
database_cross_reference: MMSL:d00142
database_cross_reference: MSH:D013806
database_cross_reference: MTH:U000362
database_cross_reference: MTH:U002295
database_cross_reference: MTHSPL:C137DTR5RG
database_cross_reference: NCI:C872
database_cross_reference: NCI_DCP:00815
database_cross_reference: NCI_DTP:NSC0002066
database_cross_reference: NCI_FDA:C137DTR5RG
database_cross_reference: NCI_NCI-GLOSS:CDR0000045358
database_cross_reference: NDDF:000602
database_cross_reference: NDFRT:N0000007076
database_cross_reference: NDFRT:N0000146467
database_cross_reference: PDQ:CDR0000041340
database_cross_reference: PSY:52580
database_cross_reference: RCD:X795w
database_cross_reference: RCD:c43..
database_cross_reference: RXNORM:10438
database_cross_reference: SNM:E-8916
database_cross_reference: SNMI:C-69510
database_cross_reference: SNOMEDCT_US:255657001
database_cross_reference: SNOMEDCT_US:372810006
database_cross_reference: SNOMEDCT_US:66493003
database_cross_reference: USPMG:MTHU001656
database_cross_reference: VANDF:4018129

Xanthinol Niacinate
type: Class
subclass of: Nicotinic Acids
MCID: MC00013751
PMOID: PMO:00017866
Subclass_of: Nicotinic Acids
Synonym: 3-Pyridinecarboxylic acid, compd. with 3,7-dihydro-7-(2-hydroxy-3-((2-hydroxyethyl)methylamino)propyl)-1,3-dimethyl-1H-purine-2,6-dione (1:1)
Synonym: Niacinate, Xanthinol
Synonym: Nicotinate, Xanthinol
Synonym: Nicotinate, Xantinol
Synonym: Xanthinol Niacinate [Chemical/Ingredient]
Synonym: Xanthinol Nicotinate
Synonym: Xantinol Nicotinate
Synonym: Xantinol nicotinate
Synonym: Xantinol nicotinate (product)
Synonym: Xantinol nicotinate (substance)
Tree Number: T6.3.2.5.10
database_cross_reference: ATC:C04AD02
database_cross_reference: CHV:0000013225
database_cross_reference: MSH:D014971
database_cross_reference: NDDF:003508
database_cross_reference: NDFRT:N0000167330
database_cross_reference: RXNORM:11358
database_cross_reference: SNOMEDCT_US:708562005
database_cross_reference: SNOMEDCT_US:715408002

Uric Acid
type: Class
subclass of: Xanthines
MCID: MC00013358
PMOID: PMO:00017868
Subclass_of: Xanthines
Synonym: 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-
Synonym: 1H-Purine-2,6,8-triol
Synonym: 2,6,8-Trihydroxypurine
Synonym: 2,6,8-Trioxopurine
Synonym: 2,6,8-Trioxypurine
Synonym: 7,9-Dihydro-1H-purine-2,6,8(3H)-trione
Synonym: 7,9-dihydro-1H-purine-2,6,8(3H)-trione
Synonym: Acid, Uric
Synonym: Trioxopurine
Synonym: UA - Uric acid
Tree Number: T6.3.3.22.4
database_cross_reference: ALT:HAUAG
database_cross_reference: AOD:0000020924
database_cross_reference: CCPSS:0035374
database_cross_reference: CHV:0000012772
database_cross_reference: DRUGBANK:DB08844
database_cross_reference: LCH:U004860
database_cross_reference: LCH_NW:sh85141398
database_cross_reference: MSH:D014527
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000356
database_cross_reference: MTHSPL:268B43MJ25
database_cross_reference: NCI:C62652
database_cross_reference: NCI_FDA:268B43MJ25
database_cross_reference: NCI_NCI-GLOSS:CDR0000393536
database_cross_reference: NDFRT:N0000166989
database_cross_reference: PSY:55010
database_cross_reference: RCD:Xa86o
database_cross_reference: RXNORM:1427088
database_cross_reference: SNM:F-11470
database_cross_reference: SNMI:F-61470
database_cross_reference: SNOMEDCT_US:1710001

Xanthine
type: Class
subclass of: Xanthines
MCID: MC00013746
PMOID: PMO:00017869
Subclass_of: Xanthines
Synonym: XANTHINE
Synonym: Xanthine (substance)
Synonym: Xanthine [Chemical/Ingredient]
Synonym: Xanthine agent
Synonym: Xanthine agent (substance)
Synonym: Xanthine product
Synonym: Xanthine product (product)
Synonym: Xanthine product (substance)
Synonym: xanthine
Tree Number: T6.3.3.22.5
database_cross_reference: CHV:0000013222
database_cross_reference: CSP:2503-3658
database_cross_reference: DRUGBANK:DB02134
database_cross_reference: LCH:U005055
database_cross_reference: LCH_NW:sh85148764
database_cross_reference: LNC:LP15953-0
database_cross_reference: LNC:MTHU014698
database_cross_reference: MSH:D019820
database_cross_reference: MTH:U002529
database_cross_reference: MTHSPL:1AVZ07U9S7
database_cross_reference: NDFRT:N0000166988
database_cross_reference: RCD:X80MI
database_cross_reference: RXNORM:1311085
database_cross_reference: SNM:F-11550
database_cross_reference: SNMI:F-61550
database_cross_reference: SNOMEDCT_US:349994006
database_cross_reference: SNOMEDCT_US:417953004
database_cross_reference: SNOMEDCT_US:46843002

Saxitoxin
type: Class
subclass of: PMO:00024388
PMOID: PMO:00017870
Subclass_of: Marine Toxins
Tree Number: T6.13.8.5.7

Pyrrolizidine Alkaloids
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
subclass of: Alkaloids
MCID: MC00011035
PMOID: PMO:00017872
Subclass_of: Alkaloids
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Alkaloids, Pyrrolizidine
Synonym: Pyrrolizidine Alkaloids [Chemical/Ingredient]
Synonym: pyrrolizidine alkaloid
Synonym: pyrrolizidine alkaloids
Tree Number: T6.3.1.1.17
Tree Number: T6.3.3.15
database_cross_reference: AOD:0000020520
database_cross_reference: CHV:0000010469
database_cross_reference: MSH:D011763
database_cross_reference: NDFRT:N0000166982

Monocrotaline
type: Class
subclass of: Pyrrolizidine Alkaloids
MCID: MC00043228
PMOID: PMO:00017873
Subclass_of: Pyrrolizidine Alkaloids
Synonym: 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-
Synonym: Crotaline
Synonym: Monocrotaline (substance)
Synonym: Monocrotaline [Chemical/Ingredient]
Synonym: monocrotaline
Tree Number: T6.3.3.15.1
database_cross_reference: CSP:0092-6734
database_cross_reference: LCH_NW:sh2005000094
database_cross_reference: MSH:D016686
database_cross_reference: NDFRT:N0000166983
database_cross_reference: SNMI:C-30335
database_cross_reference: SNOMEDCT_US:83034004

Quinazolines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00011059
PMOID: PMO:00017874
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Quinazoline
Synonym: Quinazoline (substance)
Synonym: Quinazolines [Chemical/Ingredient]
Synonym: quinazoline
Synonym: quinazolines
Tree Number: T6.3.1.1.18
database_cross_reference: AOD:0000020925
database_cross_reference: CHV:0000010492
database_cross_reference: CSP:0394-7343
database_cross_reference: LCH:U003993
database_cross_reference: LCH_NW:sh85109873
database_cross_reference: MSH:D011799
database_cross_reference: NDFRT:N0000007605
database_cross_reference: SNOMEDCT_US:406760002

Tetrodotoxin
type: Class
subclass of: PMO:00024388
MCID: MC00741253
PMOID: PMO:00017878
Subclass_of: Marine Toxins
Synonym: Tectin
Synonym: Tetrodin
Tree Number: T6.13.8.5.8
database_cross_reference: DRUGBANK:DB05232
database_cross_reference: NCI:C78845

Ketanserin
type: Class
subclass of: Piperidines
MCID: MC00007222
PMOID: PMO:00017881
Subclass_of: Piperidines
Synonym: 2,4(1H,3H)-Quinazolinedione, 3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-
Synonym: 3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione
Synonym: 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione
Synonym: KETANSERIN
Synonym: Ketanserin (product)
Synonym: Ketanserin (substance)
Synonym: Ketanserin [Chemical/Ingredient]
Synonym: ketanserin
Tree Number: T6.3.5.16.12
database_cross_reference: AOD:0000020926
database_cross_reference: ATC:C02KD01
database_cross_reference: CSP:0394-7630
database_cross_reference: DRUGBANK:DB12465
database_cross_reference: LCH_NW:sh90000693
database_cross_reference: MSH:D007650
database_cross_reference: NCI:C604
database_cross_reference: NCI_FDA:97F9DE4CT4
database_cross_reference: NDDF:005934
database_cross_reference: NDFRT:N0000167209
database_cross_reference: RXNORM:6131
database_cross_reference: SNOMEDCT_US:441818008
database_cross_reference: SNOMEDCT_US:442141001

Quinolines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00011072
PMOID: PMO:00017883
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: 1 benzazine
Synonym: Quinolines [Chemical/Ingredient]
Synonym: quinoline
Synonym: quinolines
Tree Number: T6.3.1.1.19
database_cross_reference: AOD:0000020929
database_cross_reference: CHV:0000010502
database_cross_reference: CSP:2530-4230
database_cross_reference: MSH:D011804
database_cross_reference: MTH:U002216
database_cross_reference: NDFRT:N0000007731

Kynurenic Acid
type: Class
subclass of: Xanthurenates
MCID: MC00007295
PMOID: PMO:00017892
Subclass_of: Xanthurenates
Synonym: 2-Quinolinecarboxylic acid, 4-hydroxy-
Synonym: Acid, Kynurenic
Synonym: Kynurenic Acid [Chemical/Ingredient]
Synonym: Kynurenic acid
Synonym: Kynurenic acid (substance)
Tree Number: T6.3.2.10.1
database_cross_reference: DRUGBANK:DB11937
database_cross_reference: MSH:D007736
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167315
database_cross_reference: SNM:F-11690
database_cross_reference: SNMI:F-61690
database_cross_reference: SNOMEDCT_US:39694009

Quinidine
type: Class
subclass of: Cinchona Alkaloids
subclass of: Quinuclidines
MCID: MC00011063
PMOID: PMO:00017900
Subclass_of: Cinchona Alkaloids
Subclass_of: Quinuclidines
Synonym: (+)-quinidine
Synonym: (8R,9S)-Quinidine
Synonym: (R)-(6-Methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol
Synonym: (S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
Synonym: (S)-(6-Methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol
Synonym: 6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
Synonym: 6-methoxy-α-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
Synonym: Apo Quinidine Tab 200mg
Synonym: Apo-quin-G Tab 325mg
Synonym: CIN-QUIN
Tree Number: T6.3.3.5.1
Tree Number: T6.3.4.3.2
database_cross_reference: AOD:0000020508
database_cross_reference: ATC:C01BA01
database_cross_reference: CHV:0000010495
database_cross_reference: CSP:2532-7642
database_cross_reference: DRUGBANK:DB00908
database_cross_reference: LCH:U003994
database_cross_reference: LCH_NW:sh85109879
database_cross_reference: LNC:LP16271-6
database_cross_reference: LNC:MTHU005039
database_cross_reference: MEDCIN:40570
database_cross_reference: MMSL:d00020
database_cross_reference: MSH:D011802
database_cross_reference: MTH:U002214
database_cross_reference: MTHSPL:ITX08688JL
database_cross_reference: NCI:C793
database_cross_reference: NCI_DTP:NSC0010004
database_cross_reference: NCI_FDA:ITX08688JL
database_cross_reference: NDDF:000618
database_cross_reference: NDFRT:N0000007728
database_cross_reference: NDFRT:N0000148010
database_cross_reference: PDQ:CDR0000039022
database_cross_reference: PSY:42540
database_cross_reference: RCD:bc9..
database_cross_reference: RXNORM:9068
database_cross_reference: SNM:E-7672
database_cross_reference: SNMI:C-80460
database_cross_reference: SNOMEDCT_US:31306009
database_cross_reference: SNOMEDCT_US:372697008
database_cross_reference: USPMG:MTHU000909
database_cross_reference: VANDF:4019925

Quinine
type: Class
subclass of: Cinchona Alkaloids
subclass of: Quinuclidines
MCID: MC00011066
PMOID: PMO:00017901
Subclass_of: Cinchona Alkaloids
Subclass_of: Quinuclidines
Synonym: (-)-Quinine
Synonym: (8S,9R)-Quinine
Synonym: (R)-(-)-Quinine
Synonym: (R)-(6-Methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol
Synonym: 6'-Methoxycinchonidine
Synonym: Apo-quinine Capsules
Synonym: Chinin
Synonym: Chinine
Synonym: Chininum
Synonym: Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-
Tree Number: T6.3.3.5.2
Tree Number: T6.3.4.3.3
database_cross_reference: AOD:0000020509
database_cross_reference: ATC:P01BC01
database_cross_reference: CCPSS:0022836
database_cross_reference: CHV:0000010497
database_cross_reference: CSP:2532-8110
database_cross_reference: DRUGBANK:DB00468
database_cross_reference: LCH:U003995
database_cross_reference: LCH_NW:sh85109880
database_cross_reference: LNC:LP16273-2
database_cross_reference: LNC:MTHU007609
database_cross_reference: MEDCIN:197200
database_cross_reference: MMSL:d00366
database_cross_reference: MSH:D011803
database_cross_reference: MTH:U002215
database_cross_reference: MTHSPL:A7V27PHC7A
database_cross_reference: NCI:C794
database_cross_reference: NCI_DTP:NSC0005362
database_cross_reference: NCI_DTP:NSC0192949
database_cross_reference: NCI_FDA:A7V27PHC7A
database_cross_reference: NDDF:002934
database_cross_reference: NDFRT:N0000006907
database_cross_reference: NDFRT:N0000148011
database_cross_reference: PDQ:CDR0000041253
database_cross_reference: PSY:42560
database_cross_reference: RCD:ej7..
database_cross_reference: RXNORM:9071
database_cross_reference: SNMI:C-56550
database_cross_reference: SNOMEDCT_US:373497008
database_cross_reference: SNOMEDCT_US:47065008
database_cross_reference: USPMG:MTHU000561
database_cross_reference: VANDF:4019926

Quipazine
type: Class
subclass of: Piperazines
MCID: MC00011083
PMOID: PMO:00017905
Subclass_of: Piperazines
Synonym: 2-(1-Piperazinyl)quinoline
Synonym: QUIPAZINE
Synonym: Quinoline, 2-(1-piperazinyl)-
Synonym: Quipazine [Chemical/Ingredient]
Tree Number: T6.3.5.15.25
database_cross_reference: MSH:D011814
database_cross_reference: NCI:C61919
database_cross_reference: NCI_FDA:4WCY05C0SJ
database_cross_reference: NDFRT:N0000167123

Aripiprazole
type: Class
subclass of: Piperazines
MCID: MC00104966
PMOID: PMO:00017907
Subclass_of: Piperazines
Synonym: 2(1H)-Quinolinone, 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-
Synonym: 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
Synonym: ARIPIPRAZOLE
Synonym: ARIPiprazole
Synonym: Aripiprazol
Synonym: Aripiprazole (product)
Synonym: Aripiprazole (substance)
Synonym: Aripiprazole [Chemical/Ingredient]
Synonym: Aripiprazolum
Synonym: aripiprazole
Tree Number: T6.3.5.15.1
database_cross_reference: ATC:N05AX12
database_cross_reference: CHV:0000027805
database_cross_reference: DRUGBANK:DB01238
database_cross_reference: LNC:LP34967-7
database_cross_reference: LNC:MTHU017703
database_cross_reference: MEDCIN:256544
database_cross_reference: MMSL:17034
database_cross_reference: MMSL:231328
database_cross_reference: MMSL:d04825
database_cross_reference: MSH:D000068180
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:82VFR53I78
database_cross_reference: NCI:C47403
database_cross_reference: NCI_FDA:82VFR53I78
database_cross_reference: NDDF:009852
database_cross_reference: NDFRT:N0000010069
database_cross_reference: NDFRT:N0000148786
database_cross_reference: RXNORM:89013
database_cross_reference: SNOMEDCT_US:406784005
database_cross_reference: SNOMEDCT_US:406785006
database_cross_reference: USPMG:MTHU000619
database_cross_reference: VANDF:4021367

PQQ Cofactor
type: Class
subclass of: Coenzymes
MCID: MC00031217
PMOID: PMO:00017919
Subclass_of: Coenzymes
Synonym: 1H-pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylic acid, 4,5-dihydro-4,5-dioxo-
Synonym: 2,7,9-Tricarboxy-1H-Pyrrolo-(2,3-f)Quinoline-4,5-Dione
Synonym: 2,7,9-Tricarboxypyrroloquinoline Quinone
Synonym: 4,5-Dihydro-4,5-Dioxo-1-H-Pyrrolo(2,3-f)Quinoline-2,7,9-Tricarboxylic Acid
Synonym: Coenzyme PQQ
Synonym: Coenzyme, PQQ
Synonym: Cofactor, PQQ
Synonym: Methoxatin
Synonym: PQQ Coenzyme
Synonym: PQQ Cofactor [Chemical/Ingredient]
Tree Number: T6.7.1.13
database_cross_reference: CHV:0000014383
database_cross_reference: DRUGBANK:DB03205
database_cross_reference: MSH:D045542
database_cross_reference: NDFRT:N0000168401

Quinpirole
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00036514
PMOID: PMO:00017921
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: 1H-Pyrazolo(3,4-g)quinoline, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, (4aR-trans)-
Synonym: Quinpirole [Chemical/Ingredient]
Synonym: quinpirole
Tree Number: T6.3.1.2.23
database_cross_reference: CSP:2059-0413
database_cross_reference: CSP:4003-0012
database_cross_reference: MSH:D019257
database_cross_reference: NDFRT:N0000167290
database_cross_reference: PSY:42570

Quinolizines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00011076
PMOID: PMO:00017923
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Quinolizine
Synonym: Quinolizine (substance)
Synonym: Quinolizines [Chemical/Ingredient]
Synonym: quinolizine
Tree Number: T6.3.1.1.20
database_cross_reference: CSP:2530-9849
database_cross_reference: MSH:D011807
database_cross_reference: NDFRT:N0000007734
database_cross_reference: SNOMEDCT_US:439897001

Sparteine
type: Class
subclass of: Alkaloids
MCID: MC00012067
PMOID: PMO:00017927
Subclass_of: Alkaloids
Synonym: (-)-sparteine
Synonym: 7,14-Methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-
Synonym: L-Sparteine
Synonym: Lupinidine
Synonym: Sparteine (substance)
Synonym: Sparteine [Chemical/Ingredient]
Synonym: Sparteine, (-)-Isomer
Synonym: Sparteine, (7S-(7alpha,7aalpha,14alpha,14abeta))-Isomer
Synonym: lupinidine
Synonym: sparteine
Tree Number: T6.3.3.19
database_cross_reference: AOD:0000020529
database_cross_reference: ATC:C01BA04
database_cross_reference: CSP:0091-7950
database_cross_reference: DRUGBANK:DB06727
database_cross_reference: LCH:U004403
database_cross_reference: LCH_NW:sh85126333
database_cross_reference: MSH:D013034
database_cross_reference: NDDF:001311
database_cross_reference: NDFRT:N0000166930
database_cross_reference: SNM:E-8985
database_cross_reference: SNMI:C-30337
database_cross_reference: SNOMEDCT_US:377002

Quinoxalines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00011080
PMOID: PMO:00017928
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Quinoxalines [Chemical/Ingredient]
Tree Number: T6.3.1.1.21
database_cross_reference: LCH_NW:sh2004007285
database_cross_reference: MSH:D011810
database_cross_reference: NDFRT:N0000007739

Echinomycin
type: Class
subclass of: Peptides, Cyclic
MCID: MC00004283
PMOID: PMO:00017930
Subclass_of: Peptides, Cyclic
Synonym: Bis-Quinoline Analogue
Synonym: Echinomycin A
Synonym: Echinomycin [Chemical/Ingredient]
Synonym: Levomycin
Synonym: N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide)
Synonym: Quinomycin A
Synonym: echinomycin
Synonym: quinomycin A
Tree Number: T6.10.2.15.7
Tree Number: T6.4.5.4.7
database_cross_reference: MSH:D004448
database_cross_reference: NCI:C462
database_cross_reference: NDFRT:N0000170365
database_cross_reference: PDQ:CDR0000039587

Zolazepam
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00013828
PMOID: PMO:00017932
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Pyrazolo(3,4-e)(1,4)diazepin-7(1H)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-
Synonym: ZOLAZEPAM
Synonym: Zolasepam
Synonym: Zolazepam [Chemical/Ingredient]
Synonym: zolazepam
Tree Number: T6.3.1.1.22
database_cross_reference: CHV:0000013281
database_cross_reference: LNC:LP101137-0
database_cross_reference: LNC:MTHU036082
database_cross_reference: MSH:D015041
database_cross_reference: MTHSPL:G1R474U58U
database_cross_reference: NCI:C84252
database_cross_reference: NCI_FDA:G1R474U58U
database_cross_reference: NDFRT:N0000167250
database_cross_reference: RXNORM:1535252

Ramipril
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00036568
PMOID: PMO:00017933
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: (2S-(1(R*(r*)),2alpha,3abeta,6abeta))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid
Synonym: Ach-ramipril
Synonym: Act Ramipril
Synonym: Altace Cap 1.25mg
Synonym: Altace Cap 10mg
Synonym: Altace Cap 2.5mg
Synonym: Altace Cap 5mg
Synonym: Altace Hct
Synonym: Altace Plus Felodipine 2.5mg + 2.5mg
Synonym: Altace Plus Felodipine 5mg + 5mg
Tree Number: T6.3.1.1.23
database_cross_reference: ATC:C09AA05
database_cross_reference: CHV:0000014736
database_cross_reference: DRUGBANK:DB00178
database_cross_reference: LCH_NW:sh2001004824
database_cross_reference: LNC:LP171634-1
database_cross_reference: MEDCIN:48822
database_cross_reference: MMSL:130231
database_cross_reference: MMSL:5411
database_cross_reference: MMSL:d00728
database_cross_reference: MSH:D017257
database_cross_reference: MTHSPL:L35JN3I7SJ
database_cross_reference: NCI:C29411
database_cross_reference: NCI_DCP:32054
database_cross_reference: NCI_FDA:L35JN3I7SJ
database_cross_reference: NDDF:003585
database_cross_reference: NDFRT:N0000007202
database_cross_reference: NDFRT:N0000147662
database_cross_reference: RCD:bi6..
database_cross_reference: RXNORM:35296
database_cross_reference: SNOMEDCT_US:108564000
database_cross_reference: SNOMEDCT_US:386872004
database_cross_reference: USPMG:MTHU001035
database_cross_reference: VANDF:4019562

Idazoxan
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
subclass of: Dioxanes
MCID: MC00029054
PMOID: PMO:00017934
Subclass_of: Dioxanes
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Idazoxan [Chemical/Ingredient]
Tree Number: T6.3.1.1.24
Tree Number: T6.3.5.7.3
database_cross_reference: DRUGBANK:DB12551
database_cross_reference: MSH:D019329
database_cross_reference: NDFRT:N0000167083

Benzoxazines
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
subclass of: Oxazines
MCID: MC00183597
PMOID: PMO:00017935
Subclass_of: Heterocyclic Compounds, 2-Ring
Subclass_of: Oxazines
Synonym: Benzoxazine
Synonym: Benzoxazine (substance)
Synonym: Benzoxazines [Chemical/Ingredient]
Synonym: benzoxazine
Tree Number: T6.3.1.1.26
Tree Number: T6.3.5.13.4
database_cross_reference: CSP:0779-7254
database_cross_reference: MSH:D048588
database_cross_reference: NDFRT:N0000167044
database_cross_reference: SNOMEDCT_US:713471005

Benzodioxoles
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
subclass of: Dioxoles
MCID: MC00543225
PMOID: PMO:00017936
Subclass_of: Dioxoles
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: 1,3 Dioxaindans
Synonym: 1,3 Dioxindans
Synonym: 1,3-Dioxaindans
Synonym: 1,3-Dioxindans
Synonym: Benzodioxoles [Chemical/Ingredient]
Synonym: Methylenedioxybenzenes
Tree Number: T6.3.1.1.27
Tree Number: T6.3.5.9.2
database_cross_reference: MSH:D052117
database_cross_reference: NDFRT:N0000167113

Benzothiazoles
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00543350
PMOID: PMO:00017939
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Benzothiazoles [Chemical/Ingredient]
Tree Number: T6.3.1.1.28
database_cross_reference: MSH:D052160
database_cross_reference: NDFRT:N0000167094

Isoindoles
type: Class
subclass of: Heterocyclic Compounds, 2-Ring
MCID: MC00628826
PMOID: PMO:00017940
Subclass_of: Heterocyclic Compounds, 2-Ring
Synonym: Isoindole
Synonym: Isoindoles [Chemical/Ingredient]
Tree Number: T6.3.1.1.29
database_cross_reference: LCH_NW:sh85068636
database_cross_reference: MSH:D054833
database_cross_reference: NDFRT:N0000178808

Heterocyclic Compounds, 3-Ring
type: Class
subclass of: Heterocyclic Compounds, Fused-Ring
MCID: MC00006227
PMOID: PMO:00017943
Subclass_of: Heterocyclic Compounds, Fused-Ring
Synonym: 3-Ring Heterocyclic Compounds
Synonym: 3-ring heterocyclic compounds
Synonym: Fused Heterocyclic Compounds, Three Ring
Synonym: Fused Heterocyclic Compounds, Three-Ring
Synonym: HETEROCYCLIC COMPOUNDS A 3 RING
Synonym: HETEROCYCLIC CPDS 3 RING
Synonym: Heterocyclic Compounds, 3 Ring
Synonym: Heterocyclic Compounds, 3-Ring [Chemical/Ingredient]
Synonym: Heterocyclic Cpds, 3 Ring
Synonym: Three Ring Heterocyclic Compounds
Tree Number: T6.3.1.2
database_cross_reference: AOD:0000020934
database_cross_reference: MSH:D006575
database_cross_reference: NDFRT:N0000008096

Dibenzofurans
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC01054807
PMOID: PMO:00017944
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Dibenzofurans [Chemical/Ingredient]
Synonym: Furans, Dibenzo
Tree Number: T6.3.1.2.3
database_cross_reference: MSH:D000072318
database_cross_reference: NDFRT:N0000193128

Acridines
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00000267
PMOID: PMO:00017945
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Acridine
Synonym: Acridine (substance)
Synonym: Acridines [Chemical/Ingredient]
Synonym: acridine
Synonym: acridines
Tree Number: T6.3.1.2.4
database_cross_reference: AOD:0000020936
database_cross_reference: CHV:0000000652
database_cross_reference: CSP:0032-9648
database_cross_reference: LCH:U000041
database_cross_reference: LCH_NW:sh85000650
database_cross_reference: MSH:D000166
database_cross_reference: NCI:C203
database_cross_reference: NDFRT:N0000008155
database_cross_reference: SNOMEDCT_US:413431008

Acridones
type: Class
subclass of: Alkaloids
MCID: MC00628825
PMOID: PMO:00017956
Subclass_of: Alkaloids
Synonym: Acridones [Chemical/Ingredient]
Tree Number: T6.3.3.31
database_cross_reference: MSH:D054831
database_cross_reference: NDFRT:N0000178807

Acronine
type: Class
subclass of: Acridones
MCID: MC00000277
PMOID: PMO:00017957
Subclass_of: Acridones
Synonym: 7H-Pyrano(2,3-c)acridin-7-one, 3,12-dihydro-6-methoxy-3,3,12-trimethyl-
Synonym: ACRONINE
Synonym: Acronine [Chemical/Ingredient]
Synonym: Acronycin
Synonym: Acronycine
Tree Number: T6.3.3.31.1
database_cross_reference: MSH:D000175
database_cross_reference: NCI:C75297
database_cross_reference: NCI_FDA:QE0G097358
database_cross_reference: NDFRT:N0000167268

Spectinomycin
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
subclass of: Dioxanes
subclass of: PMO:00020951
MCID: MC00000297
PMOID: PMO:00017958
Subclass_of: Aminoglycosides
Subclass_of: Dioxanes
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: 4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, (2R-(2alpha,4abeta,5abeta,6beta,7beta,8beta,9alpha,9aalpha,10abeta))-
Synonym: Actinospectacin
Synonym: Actinospectacina
Synonym: Espectinomicina
Synonym: SCM
Synonym: SPECTINOMYCIN
Synonym: Spectinomicina
Synonym: Spectinomycin (product)
Synonym: Spectinomycin (substance)
Synonym: Spectinomycin [Chemical/Ingredient]
Tree Number: T6.3.1.2.5
Tree Number: T6.3.5.7.1
Tree Number: T6.8.6.1.1
database_cross_reference: ATC:J01XX04
database_cross_reference: CHV:0000000674
database_cross_reference: DRUGBANK:DB00919
database_cross_reference: LNC:LP16381-3
database_cross_reference: LNC:MTHU008480
database_cross_reference: MMSL:d00372
database_cross_reference: MSH:D000198
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:93AKI1U6QF
database_cross_reference: NCI:C61951
database_cross_reference: NCI_FDA:93AKI1U6QF
database_cross_reference: NDDF:004865
database_cross_reference: NDFRT:N0000006595
database_cross_reference: NDFRT:N0000148017
database_cross_reference: RCD:eb6..
database_cross_reference: RXNORM:270
database_cross_reference: SNM:E-7228
database_cross_reference: SNMI:C-52280
database_cross_reference: SNOMEDCT_US:372882007
database_cross_reference: SNOMEDCT_US:86066003
database_cross_reference: VANDF:4019932

Cinoxacin
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
subclass of: Acids, Heterocyclic
MCID: MC00002912
PMOID: PMO:00017959
Subclass_of: Acids, Heterocyclic
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: (1,3)Dioxolo(4,5-g)cinnoline-3-carboxylic acid, 1-ethyl-1,4-dihydro-4-oxo-
Synonym: 1-Ethyl-1,4-Dihydro-4-oxo [1,3] Dioxolo [4,5-g] Cinnoline-3-Carboxylic Acid
Synonym: 1-Ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid
Synonym: 5-Ethyl-8-oxo-5,8-dihydro-1,3-dioxa-5,6-diaza-cyclopenta[b]naphthalene-7-carboxylic acid
Synonym: Acid, Azolinic
Synonym: Azolinic Acid
Synonym: CINOXACIN
Synonym: Cinoxacin (product)
Synonym: Cinoxacin (substance)
Synonym: Cinoxacin [Chemical/Ingredient]
Tree Number: T6.3.1.2.9
Tree Number: T6.3.2.1
database_cross_reference: ATC:J01MB06
database_cross_reference: CHV:0000003000
database_cross_reference: DRUGBANK:DB00827
database_cross_reference: LNC:LP15356-6
database_cross_reference: LNC:MTHU007845
database_cross_reference: MEDCIN:48447
database_cross_reference: MMSL:109
database_cross_reference: MMSL:4450
database_cross_reference: MMSL:d01129
database_cross_reference: MSH:D002937
database_cross_reference: NCI:C65333
database_cross_reference: NCI_FDA:LMK22VUH23
database_cross_reference: NDDF:002865
database_cross_reference: NDFRT:N0000007043
database_cross_reference: NDFRT:N0000147347
database_cross_reference: RCD:eg2..
database_cross_reference: RXNORM:2550
database_cross_reference: SNMI:C-55750
database_cross_reference: SNOMEDCT_US:387549004
database_cross_reference: SNOMEDCT_US:96081007
database_cross_reference: VANDF:4019087

Dactinomycin
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
subclass of: Peptides, Cyclic
MCID: MC00003537
PMOID: PMO:00017960
Subclass_of: Heterocyclic Compounds, 3-Ring
Subclass_of: Peptides, Cyclic
Synonym: 2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-I)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Synonym: 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3
Synonym: ACT-D
Synonym: ACTINOMYCIN D
Synonym: AD
Synonym: ActD
Synonym: Actinomycin A IV
Synonym: Actinomycin C1
Synonym: Actinomycin D
Synonym: Actinomycin I1
Tree Number: T6.10.2.15.6
Tree Number: T6.3.1.2.10
Tree Number: T6.4.5.4.6
database_cross_reference: ATC:L01DA01
database_cross_reference: CHV:0000003600
database_cross_reference: CSP:0190-4841
database_cross_reference: DRUGBANK:DB00970
database_cross_reference: MEDCIN:40492
database_cross_reference: MEDCIN:48457
database_cross_reference: MMSL:174221
database_cross_reference: MMSL:4530
database_cross_reference: MMSL:d00203
database_cross_reference: MSH:D003609
database_cross_reference: MTH:U001845
database_cross_reference: MTHSPL:1CC1JFE158
database_cross_reference: NCI:C412
database_cross_reference: NCI_DCP:00417
database_cross_reference: NCI_DTP:NSC0003053
database_cross_reference: NCI_FDA:1CC1JFE158
database_cross_reference: NCI_NCI-GLOSS:CDR0000045237
database_cross_reference: NDDF:002657
database_cross_reference: NDFRT:N0000006852
database_cross_reference: NDFRT:N0000146314
database_cross_reference: PDQ:CDR0000039675
database_cross_reference: RCD:h21..
database_cross_reference: RXNORM:3100
database_cross_reference: SNM:E-8344
database_cross_reference: SNMI:C-780A0
database_cross_reference: SNOMEDCT_US:360183007
database_cross_reference: SNOMEDCT_US:387353003
database_cross_reference: SNOMEDCT_US:64127001
database_cross_reference: VANDF:4017964

Dibenzazepines
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00003839
PMOID: PMO:00017961
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Dibenzazepines [Chemical/Ingredient]
Synonym: dibenzazepines
Tree Number: T6.3.1.2.11
database_cross_reference: AOD:0000020941
database_cross_reference: MSH:D003984
database_cross_reference: NDFRT:N0000007962

Dibenzoxazepines
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00003844
PMOID: PMO:00017971
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Dibenzoxazepines [Chemical/Ingredient]
Synonym: dibenzoxazepine
Synonym: dibenzoxazepines
Tree Number: T6.3.1.2.14
database_cross_reference: AOD:0000020945
database_cross_reference: CHV:0000003880
database_cross_reference: MSH:D003989
database_cross_reference: NDFRT:N0000007966

Dibenzoxepins
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00003845
PMOID: PMO:00017975
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Dibenzoxepins [Chemical/Ingredient]
Synonym: dibenzoxepins
Tree Number: T6.3.1.2.15
database_cross_reference: AOD:0000020948
database_cross_reference: MSH:D003990
database_cross_reference: NDFRT:N0000007967

Phenanthridines
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00009997
PMOID: PMO:00017977
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Phenanthridines [Chemical/Ingredient]
Synonym: phenanthridine
Tree Number: T6.3.1.2.17
database_cross_reference: CSP:2259-2259
database_cross_reference: MSH:D010617
database_cross_reference: NDFRT:N0000167285

Benzophenanthridines
type: Class
subclass of: Heterocyclic Compounds, 4 or More Rings
subclass of: Alkaloids
MCID: MC00583133
PMOID: PMO:00017980
Subclass_of: Alkaloids
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Synonym: Benzophenanthridines [Chemical/Ingredient]
Tree Number: T6.3.1.3.13
Tree Number: T6.3.3.29
database_cross_reference: MSH:D053119
database_cross_reference: NDFRT:N0000175102

Phenanthrolines
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00009998
PMOID: PMO:00017981
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Phenanthrolines [Chemical/Ingredient]
Synonym: phenanthroline
Tree Number: T6.3.1.2.18
database_cross_reference: AOD:0000020951
database_cross_reference: CSP:2259-3999
database_cross_reference: MSH:D010618
database_cross_reference: NDFRT:N0000167284

Phenazines
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00009999
PMOID: PMO:00017982
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Phenazine
Synonym: Phenazines [Chemical/Ingredient]
Synonym: phenazine
Tree Number: T6.3.1.2.19
database_cross_reference: AOD:0000020952
database_cross_reference: CSP:0394-6877
database_cross_reference: LCH_NW:sh2007006398
database_cross_reference: MSH:D010619
database_cross_reference: MTH:U002156
database_cross_reference: NDFRT:N0000007518

Pyocyanine
type: Class
subclass of: PMO:00024379
MCID: MC00010970
PMOID: PMO:00017986
Subclass_of: Pigments, Biological
Synonym: 1(5H)-Phenazinone, 5-methyl-
Synonym: Pyocyanin
Synonym: Pyocyanin (substance)
Synonym: Pyocyanine [Chemical/Ingredient]
Synonym: pyocyanin
Synonym: pyocyanine
Tree Number: T6.13.7.16
database_cross_reference: CHV:0000010438
database_cross_reference: MSH:D011710
database_cross_reference: NDFRT:N0000171196
database_cross_reference: SNMI:F-62B80
database_cross_reference: SNOMEDCT_US:19872007

Xanthenes
type: Class
subclass of: Heterocyclic Compounds, 3-Ring
MCID: MC00013745
PMOID: PMO:00017987
Subclass_of: Heterocyclic Compounds, 3-Ring
Synonym: Xanthene
Synonym: Xanthenes [Chemical/Ingredient]
Synonym: xanthene
Synonym: xanthenes
Tree Number: T6.3.1.2.22
database_cross_reference: AOD:0000020961
database_cross_reference: CHV:0000013221
database_cross_reference: CSP:0396-2545
database_cross_reference: LCH:U005054
database_cross_reference: LCH_NW:sh85148760
database_cross_reference: MSH:D014966
database_cross_reference: NDFRT:N0000008115

Sterigmatocystin
type: Class
subclass of: PMO:00024389
MCID: MC00012221
PMOID: PMO:00017992
Subclass_of: Mycotoxins
Synonym: 7H-Furo(3',2':4,5)furo(2,3-c)xanthen-7-one, 3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR-cis)-
Synonym: Sterigmatocystin (substance)
Synonym: Sterigmatocystin [Chemical/Ingredient]
Tree Number: T6.13.8.6.13
database_cross_reference: MSH:D013241
database_cross_reference: NDFRT:N0000171428
database_cross_reference: SNMI:C-30866
database_cross_reference: SNOMEDCT_US:28825003

Heterocyclic Compounds, 4 or More Rings
type: Class
subclass of: Heterocyclic Compounds, Fused-Ring
MCID: MC00006228
PMOID: PMO:00017993
Subclass_of: Heterocyclic Compounds, Fused-Ring
Synonym: 4 or more ring heterocyclic compounds
Synonym: 4-ring or more heterocyclic compounds
Synonym: HETEROCYCLIC COMPOUNDS A 4 OR MORE RINGS
Synonym: HETEROCYCLIC CPDS WITH 4 OR MORE RINGS
Synonym: Heterocyclic Compounds with 4 or More Rings
Synonym: Heterocyclic Compounds with Four or More Rings
Synonym: Heterocyclic Compounds, 4 or More Rings [Chemical/Ingredient]
Synonym: Heterocyclic Cpds, 4 or More Rings
Tree Number: T6.3.1.3
database_cross_reference: AOD:0000020966
database_cross_reference: AOD:0000029110
database_cross_reference: MSH:D006576
database_cross_reference: NDFRT:N0000008261

Berberine Alkaloids
type: Class
subclass of: Benzylisoquinolines
subclass of: Heterocyclic Compounds, 4 or More Rings
MCID: MC00001619
PMOID: PMO:00017994
Subclass_of: Benzylisoquinolines
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Synonym: Alkaloids, Berberine
Synonym: Berberine Alkaloids [Chemical/Ingredient]
Synonym: Berbines
Tree Number: T6.3.1.3.2
Tree Number: T6.3.3.26.2
database_cross_reference: MSH:D001600
database_cross_reference: NDFRT:N0000167308

Cevanes
type: Class
subclass of: Heterocyclic Compounds, 4 or More Rings
subclass of: Veratrum Alkaloids
MCID: MC00002572
PMOID: PMO:00017996
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Subclass_of: Veratrum Alkaloids
Synonym: Alkaloids, Cevane
Synonym: Cevane Alkaloids
Synonym: Cevanes [Chemical/Ingredient]
Tree Number: T6.3.1.3.3
Tree Number: T6.3.3.21.1
database_cross_reference: MSH:D002595
database_cross_reference: NDFRT:N0000008049

Dihydro-beta-Erythroidine
type: Class
subclass of: Heterocyclic Compounds, 4 or More Rings
subclass of: Alkaloids
MCID: MC00003917
PMOID: PMO:00018001
Subclass_of: Alkaloids
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Synonym: 16(15H)-Oxaerythrinan-15-one, 1,6-didehydro-14,17-dihydro-3-methoxy-, (3beta)-
Synonym: Dihydro beta Erythroidine
Synonym: Dihydro-beta-Erythroidine [Chemical/Ingredient]
Synonym: Erythroidine, Dihydro beta
Synonym: beta Erythroidine, Dihydro
Tree Number: T6.3.1.3.4
Tree Number: T6.3.3.7
database_cross_reference: MSH:D004079
database_cross_reference: NDFRT:N0000167310

Ergolines
type: Class
subclass of: Heterocyclic Compounds, 4 or More Rings
subclass of: Ergot Alkaloids
MCID: MC00004647
PMOID: PMO:00018002
Subclass_of: Ergot Alkaloids
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Synonym: Ergolines [Chemical/Ingredient]
Synonym: ergoline
Synonym: ergolines
Tree Number: T6.3.1.3.5
Tree Number: T6.3.3.9.1
database_cross_reference: AOD:0000020514
database_cross_reference: CHV:0000004597
database_cross_reference: CSP:0092-2250
database_cross_reference: MSH:D004873
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007618

Ergotamines
type: Class
subclass of: Heterocyclic Compounds, 4 or More Rings
subclass of: Ergot Alkaloids
MCID: MC00004652
PMOID: PMO:00018013
Subclass_of: Ergot Alkaloids
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Synonym: (5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione
Synonym: 12'-Hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione
Synonym: Anervan
Synonym: Antimigraine
Synonym: Bellergal Spacetabs
Synonym: Bellergal Tab
Synonym: Cafergot Pb Sup
Synonym: Cafergot Pb Tab
Synonym: Cafergot Sup
Synonym: Cafergot Tab
Tree Number: T6.3.1.3.6
Tree Number: T6.3.3.9.2
database_cross_reference: ATC:N02CA02
database_cross_reference: CHV:0000004602
database_cross_reference: DRUGBANK:DB00201
database_cross_reference: DRUGBANK:DB00696
database_cross_reference: LNC:LP17994-2
database_cross_reference: LNC:MTHU024862
database_cross_reference: MEDCIN:79646
database_cross_reference: MMSL:d00222
database_cross_reference: MSH:D004878
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:PR834Q503T
database_cross_reference: NCI:C61751
database_cross_reference: NCI_FDA:PR834Q503T
database_cross_reference: NDDF:004526
database_cross_reference: NDFRT:N0000006354
database_cross_reference: NDFRT:N0000020412
database_cross_reference: RCD:x01R8
database_cross_reference: RXNORM:4025
database_cross_reference: SNM:E-8969
database_cross_reference: SNMI:C-68470
database_cross_reference: SNOMEDCT_US:32647002
database_cross_reference: SNOMEDCT_US:363568006
database_cross_reference: SNOMEDCT_US:395975005
database_cross_reference: USPMG:MTHU000424
database_cross_reference: VANDF:4022407

Morphinans
type: Class
subclass of: Phenanthrenes
subclass of: Heterocyclic Compounds, 4 or More Rings
subclass of: Opiate Alkaloids
subclass of: Heterocyclic Compounds, Bridged-Ring
MCID: MC00008411
PMOID: PMO:00018021
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Subclass_of: Heterocyclic Compounds, Bridged-Ring
Subclass_of: Opiate Alkaloids
Subclass_of: Phenanthrenes
Synonym: Morphinans [Chemical/Ingredient]
Synonym: morphinan
Synonym: morphinans
Tree Number: T6.3.1.3.8
Tree Number: T6.3.3.30.1
Tree Number: T6.3.4.2
Tree Number: T6.4.3.8.2
database_cross_reference: AOD:0000020564
database_cross_reference: CSP:0092-6917
database_cross_reference: MSH:D009019
database_cross_reference: NDFRT:N0000008069

Buprenorphine
type: Class
subclass of: Morphinans
MCID: MC00002026
PMOID: PMO:00018022
Subclass_of: Morphinans
Synonym: (-)-Buprenorphine
Synonym: (-)-buprenorphine
Synonym: (−)-buprenorphine
Synonym: 17-Cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol
Synonym: 2-(N-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol
Synonym: 2-[3-Cyclopropylmethyl-11-hydroxy-15-methoxy-(14R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-3,3-dimethyl-2-butanol
Synonym: 21-Cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
Synonym: 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-
Synonym: Act Buprenorphine/naloxone
Synonym: Addnok
Tree Number: T6.3.4.2.1
database_cross_reference: AOD:0000020571
database_cross_reference: ATC:N02AE01
database_cross_reference: ATC:N07BC01
database_cross_reference: CHV:0000002227
database_cross_reference: CSP:0092-7100
database_cross_reference: DRUGBANK:DB00921
database_cross_reference: LCH:U000715
database_cross_reference: LCH_NW:sh85018028
database_cross_reference: LNC:LP16054-6
database_cross_reference: LNC:MTHU006723
database_cross_reference: MMSL:27271
database_cross_reference: MMSL:d00840
database_cross_reference: MSH:D002047
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:40D3SCR4GZ
database_cross_reference: NCI:C61656
database_cross_reference: NCI_FDA:40D3SCR4GZ
database_cross_reference: NDDF:004632
database_cross_reference: NDFRT:N0000007417
database_cross_reference: NDFRT:N0000147737
database_cross_reference: RCD:dj3..
database_cross_reference: RXNORM:1819
database_cross_reference: SNMI:C-60A10
database_cross_reference: SNOMEDCT_US:31684002
database_cross_reference: SNOMEDCT_US:370250006
database_cross_reference: SNOMEDCT_US:387173000
database_cross_reference: USPMG:MTHU000015
database_cross_reference: VANDF:4019644

Buprenorphine, Naloxone Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00396521
PMOID: PMO:00018023
Subclass_of: Drug Combinations
Synonym: BUPRENORPHINE/NALOXONE
Synonym: Buprenorphine + naloxone
Synonym: Buprenorphine / Naloxone
Synonym: Buprenorphine Naloxone
Synonym: Buprenorphine Naloxone Combination
Synonym: Buprenorphine Naloxone Drug Combination
Synonym: Buprenorphine and Naloxone
Synonym: Buprenorphine+naloxone
Synonym: Buprenorphine+naloxone (product)
Synonym: Buprenorphine, Naloxone Drug Combination [Chemical/Ingredient]
Tree Number: T6.15.3.12
database_cross_reference: DRUGBANK:DB00921
database_cross_reference: DRUGBANK:DB01183
database_cross_reference: MMSL:d04819
database_cross_reference: MSH:D000069479
database_cross_reference: NDFRT:N0000022301
database_cross_reference: NDFRT:N0000191943
database_cross_reference: RXNORM:352364
database_cross_reference: SNOMEDCT_US:425741009
database_cross_reference: USPMG:MTHU002067
database_cross_reference: VANDF:4024297

Butorphanol
type: Class
subclass of: Morphinans
MCID: MC00002052
PMOID: PMO:00018024
Subclass_of: Morphinans
Synonym: (-)-17-(Cyclobutylmethyl)morphinan-3,14-diol
Synonym: (-)-Butorphanol
Synonym: (-)-N-Cyclobutylmethyl-3,14-dihydroxymorphinan
Synonym: 17-(Cyclobutylmethyl)morphinan-3,14-diol
Synonym: BUTORPHANOL
Synonym: Butaro
Synonym: Butorfanol
Synonym: Butorphanol (product)
Synonym: Butorphanol (substance)
Synonym: Butorphanol [Chemical/Ingredient]
Tree Number: T6.3.4.2.2
database_cross_reference: ATC:N02AF01
database_cross_reference: CHV:0000002252
database_cross_reference: DRUGBANK:DB00611
database_cross_reference: LNC:LP17844-9
database_cross_reference: LNC:MTHU003006
database_cross_reference: MMSL:d00838
database_cross_reference: MSH:D002077
database_cross_reference: MTHSPL:QV897JC36D
database_cross_reference: NCI:C61659
database_cross_reference: NCI_FDA:QV897JC36D
database_cross_reference: NDDF:004635
database_cross_reference: NDFRT:N0000005711
database_cross_reference: NDFRT:N0000147743
database_cross_reference: RXNORM:1841
database_cross_reference: SNM:E-7790
database_cross_reference: SNMI:C-60A20
database_cross_reference: SNOMEDCT_US:13936006
database_cross_reference: SNOMEDCT_US:370230007
database_cross_reference: SNOMEDCT_US:373467000
database_cross_reference: USPMG:MTHU000016
database_cross_reference: VANDF:4019650

Dextromethorphan
type: Class
subclass of: Morphinans
MCID: MC00003787
PMOID: PMO:00018025
Subclass_of: Morphinans
Synonym: (+)-dextromethorphan
Synonym: 12 Hour Cough Relief
Synonym: 7 Select Cough DM
Synonym: 7 Select Day Time Relief
Synonym: 7 Select Night Time Relief
Synonym: 7 select Tussin DM
Synonym: A.M. Cold Relief Formula
Synonym: ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and DOXYLAMINE SUCCINATE
Synonym: ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and PHENYLEPHRINE HYDROCHLORIDE
Synonym: ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and DOXYLAMINE SUCCINATE
Tree Number: T6.3.4.2.3
database_cross_reference: ATC:R05DA09
database_cross_reference: CHV:0000003830
database_cross_reference: CSP:4007-0038
database_cross_reference: DRUGBANK:DB00514
database_cross_reference: LCH_NW:sh2007010731
database_cross_reference: LNC:LP16105-6
database_cross_reference: LNC:MTHU004183
database_cross_reference: MEDCIN:197230
database_cross_reference: MMSL:4565
database_cross_reference: MMSL:73044
database_cross_reference: MMSL:d00207
database_cross_reference: MSH:D003915
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7355X3ROTS
database_cross_reference: NCI:C62022
database_cross_reference: NCI_FDA:7355X3ROTS
database_cross_reference: NDDF:004427
database_cross_reference: NDFRT:N0000006161
database_cross_reference: NDFRT:N0000146393
database_cross_reference: RXNORM:3289
database_cross_reference: SNM:E-7844
database_cross_reference: SNMI:C-88130
database_cross_reference: SNOMEDCT_US:2016004
database_cross_reference: SNOMEDCT_US:387114001
database_cross_reference: VANDF:4018052

Dextrorphan
type: Class
subclass of: Morphinans
MCID: MC00003790
PMOID: PMO:00018026
Subclass_of: Morphinans
Synonym: (+-)-17-Methylmorphinan-3-ol
Synonym: Dextrorphan [Chemical/Ingredient]
Synonym: Morphinan-3-ol, 17-methyl-, (9alpha,13alpha,14alpha)-
Tree Number: T6.3.4.2.4
database_cross_reference: LNC:LP158084-6
database_cross_reference: LNC:MTHU046336
database_cross_reference: MSH:D003917
database_cross_reference: NDFRT:N0000167299

Diprenorphine
type: Class
subclass of: Morphinans
MCID: MC00004024
PMOID: PMO:00018027
Subclass_of: Morphinans
Synonym: 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,alpha-dimethyl-, (5alpha,7alpha)-
Synonym: Diprenorfin
Synonym: Diprenorphine (substance)
Synonym: Diprenorphine [Chemical/Ingredient]
Synonym: M5050
Tree Number: T6.3.4.2.5
database_cross_reference: DRUGBANK:DB01548
database_cross_reference: MSH:D004174
database_cross_reference: NDFRT:N0000167307
database_cross_reference: SNM:E-8821
database_cross_reference: SNMI:C-60D50
database_cross_reference: SNOMEDCT_US:28580002

Etorphine
type: Class
subclass of: Morphinans
MCID: MC00004828
PMOID: PMO:00018028
Subclass_of: Morphinans
Synonym: 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-, (5alpha,7alpha(R))-
Synonym: ETORPHINE
Synonym: Ethorphine
Synonym: Etorphine (substance)
Synonym: Etorphine [Chemical/Ingredient]
Synonym: Etorphinum
Synonym: etorphine
Tree Number: T6.3.4.2.6
database_cross_reference: CHV:0000004725
database_cross_reference: DRUGBANK:DB01497
database_cross_reference: MSH:D005048
database_cross_reference: NCI:C80578
database_cross_reference: NCI_FDA:42M2Y6NU9O
database_cross_reference: NDFRT:N0000167306
database_cross_reference: SNMI:C-60790
database_cross_reference: SNOMEDCT_US:96188003

Levallorphan
type: Class
subclass of: Morphinans
MCID: MC00007534
PMOID: PMO:00018029
Subclass_of: Morphinans
Synonym: LEVALLORPHAN
Synonym: Levallofano
Synonym: Levallorphan (substance)
Synonym: Levallorphan - chemical
Synonym: Levallorphan - chemical (substance)
Synonym: Levallorphan [Chemical/Ingredient]
Synonym: Levallorphanum
Synonym: Levalorfano
Synonym: Lévallorphane
Synonym: Morphinan-3-ol, 17-(2-propenyl)-
Tree Number: T6.3.4.2.7
database_cross_reference: AOD:0000020567
database_cross_reference: DRUGBANK:DB00504
database_cross_reference: MSH:D007977
database_cross_reference: NCI:C66004
database_cross_reference: NCI_FDA:353613BU4U
database_cross_reference: NDDF:004660
database_cross_reference: NDFRT:N0000167305
database_cross_reference: RXNORM:6370
database_cross_reference: SNM:E-8802
database_cross_reference: SNMI:C-60D30
database_cross_reference: SNOMEDCT_US:17008002
database_cross_reference: SNOMEDCT_US:360186004

Levorphanol
type: Class
subclass of: Morphinans
MCID: MC00007542
PMOID: PMO:00018030
Subclass_of: Morphinans
Synonym: Aromarone
Synonym: Cetarin
Synonym: LEVORPHANOL
Synonym: Levodroman
Synonym: Levorfanol
Synonym: Levorfanolo
Synonym: Levorphan
Synonym: Levorphanol (product)
Synonym: Levorphanol (substance)
Synonym: Levorphanol [Chemical/Ingredient]
Tree Number: T6.3.4.2.8
database_cross_reference: AOD:0000020566
database_cross_reference: CHV:0000007379
database_cross_reference: CSP:0092-6917
database_cross_reference: DRUGBANK:DB00854
database_cross_reference: LNC:LP16173-4
database_cross_reference: LNC:MTHU006727
database_cross_reference: MMSL:d00825
database_cross_reference: MSH:D007981
database_cross_reference: MTHSPL:27618J1N2X
database_cross_reference: NCI:C61810
database_cross_reference: NCI_FDA:27618J1N2X
database_cross_reference: NDDF:004625
database_cross_reference: NDFRT:N0000006702
database_cross_reference: NDFRT:N0000147890
database_cross_reference: RCD:x02Mw
database_cross_reference: RXNORM:6378
database_cross_reference: SNM:E-7794
database_cross_reference: SNMI:C-60680
database_cross_reference: SNOMEDCT_US:387275004
database_cross_reference: SNOMEDCT_US:50335004
database_cross_reference: USPMG:MTHU000006
database_cross_reference: VANDF:4019801

Morphine Derivatives
type: Class
subclass of: Morphinans
MCID: MC00008415
PMOID: PMO:00018031
Subclass_of: Morphinans
Synonym: (−)-morphine
Synonym: Morphine Derivatives Including Cocaine
Synonym: Morphine Derivatives [Chemical/Ingredient]
Synonym: Morphines
Tree Number: T6.3.4.2.9
database_cross_reference: DRUGBANK:DB00295
database_cross_reference: MSH:D009022
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008072

Nalbuphine
type: Class
subclass of: Morphinans
MCID: MC00008643
PMOID: PMO:00018042
Subclass_of: Morphinans
Synonym: Mexifen
Synonym: Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, (5alpha,6alpha)-
Synonym: N-Cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol
Synonym: NALBUPHINE
Synonym: Nalbufina
Synonym: Nalbuphin
Synonym: Nalbuphine (product)
Synonym: Nalbuphine (substance)
Synonym: Nalbuphine [Chemical/Ingredient]
Synonym: Nalbuphine product
Tree Number: T6.3.4.2.10
database_cross_reference: ATC:N02AF02
database_cross_reference: CCPSS:0045390
database_cross_reference: CHV:0000008469
database_cross_reference: DRUGBANK:DB00844
database_cross_reference: LCH_NW:sh91004127
database_cross_reference: LNC:LP16212-0
database_cross_reference: LNC:MTHU006731
database_cross_reference: MMSL:d00839
database_cross_reference: MSH:D009266
database_cross_reference: MTHSPL:L2T84IQI2K
database_cross_reference: NCI:C61854
database_cross_reference: NCI_FDA:L2T84IQI2K
database_cross_reference: NDDF:004627
database_cross_reference: NDFRT:N0000007291
database_cross_reference: NDFRT:N0000147937
database_cross_reference: RCD:x01Kk
database_cross_reference: RXNORM:7238
database_cross_reference: SNM:E-778X
database_cross_reference: SNMI:C-60A30
database_cross_reference: SNOMEDCT_US:370262005
database_cross_reference: SNOMEDCT_US:373539006
database_cross_reference: SNOMEDCT_US:83085007
database_cross_reference: USPMG:MTHU000027
database_cross_reference: VANDF:4019851

Nalorphine
type: Class
subclass of: Morphinans
MCID: MC00008646
PMOID: PMO:00018043
Subclass_of: Morphinans
Synonym: Allylnormorphine
Synonym: Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-(2-propenyl)-, (5alpha,6alpha)-
Synonym: N-allylnormorphine
Synonym: Nalorphine (product)
Synonym: Nalorphine (substance)
Synonym: Nalorphine - chemical
Synonym: Nalorphine - chemical (substance)
Synonym: Nalorphine [Chemical/Ingredient]
Synonym: nalorphine
Tree Number: T6.3.4.2.11
database_cross_reference: AOD:0000020549
database_cross_reference: ATC:V03AB02
database_cross_reference: CHV:0000008471
database_cross_reference: CSP:0092-8198
database_cross_reference: LNC:LP16213-8
database_cross_reference: LNC:MTHU017460
database_cross_reference: MSH:D009269
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:004659
database_cross_reference: NDFRT:N0000167300
database_cross_reference: PSY:32940
database_cross_reference: SNM:E-8805
database_cross_reference: SNMI:C-60D40
database_cross_reference: SNOMEDCT_US:360199001
database_cross_reference: SNOMEDCT_US:373774009
database_cross_reference: SNOMEDCT_US:6526001

Naloxone
type: Class
subclass of: Morphinans
MCID: MC00008647
PMOID: PMO:00018044
Subclass_of: Morphinans
Synonym: (-)-Naloxone
Synonym: 1-N-Allyl-14-hydroxynordihydromorphinone
Synonym: 17-Allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one
Synonym: Act Buprenorphine/naloxone
Synonym: Buprenorphine HCl and Naloxone HCl
Synonym: Buprenorphine Hydrochloride and Naloxone Hydrochloride Dihydrate
Synonym: EN 1530 Base
Synonym: Injectable Naloxone Hydrochloride
Synonym: L-Naloxone
Synonym: Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-
Tree Number: T6.3.4.2.12
database_cross_reference: AOD:0000020562
database_cross_reference: ATC:A06AH04
database_cross_reference: ATC:V03AB15
database_cross_reference: CHV:0000008472
database_cross_reference: CSP:0092-8381
database_cross_reference: DRUGBANK:DB01183
database_cross_reference: LCH:U003114
database_cross_reference: LCH_NW:sh85089574
database_cross_reference: LNC:LP28525-1
database_cross_reference: LNC:MTHU013159
database_cross_reference: MMSL:27364
database_cross_reference: MMSL:d00311
database_cross_reference: MSH:D009270
database_cross_reference: MTHSPL:36B82AMQ7N
database_cross_reference: NCI:C62054
database_cross_reference: NCI_DCP:30318
database_cross_reference: NCI_DTP:NSC0070413
database_cross_reference: NCI_FDA:36B82AMQ7N
database_cross_reference: NCI_NCI-GLOSS:CDR0000045228
database_cross_reference: NDDF:004661
database_cross_reference: NDFRT:N0000007312
database_cross_reference: NDFRT:N0000147938
database_cross_reference: PDQ:CDR0000039509
database_cross_reference: PSY:32944
database_cross_reference: RCD:x01GS
database_cross_reference: RXNORM:7242
database_cross_reference: SNM:E-8811
database_cross_reference: SNMI:C-60D10
database_cross_reference: SNOMEDCT_US:372890007
database_cross_reference: SNOMEDCT_US:89018006
database_cross_reference: USPMG:MTHU001786
database_cross_reference: VANDF:4019852

Rifamycins
type: Class
subclass of: Lactams, Macrocyclic
subclass of: Heterocyclic Compounds, 4 or More Rings
MCID: MC00011411
PMOID: PMO:00018046
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Subclass_of: Lactams, Macrocyclic
Synonym: 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-B)furan-1,11(2h)-dione 21-Acetate
Synonym: M-14
Synonym: Rifamicine SV
Synonym: Rifamycin
Synonym: Rifamycin SV
Synonym: Rifamycins (substance)
Synonym: Rifamycins [Chemical/Ingredient]
Synonym: Rifomycin SV
Synonym: Rifomycins
Synonym: rifamycin
Tree Number: T6.3.1.3.9
Tree Number: T6.4.5.7.2
database_cross_reference: AOD:0000019213
database_cross_reference: CHV:0000010898
database_cross_reference: CSP:0206-9495
database_cross_reference: DRUGBANK:DB11753
database_cross_reference: LCH_NW:sh85114063
database_cross_reference: MEDCIN:194704
database_cross_reference: MSH:D012294
database_cross_reference: MTH:U002228
database_cross_reference: NCI:C29406
database_cross_reference: NDFRT:N0000007911
database_cross_reference: RXNORM:9385
database_cross_reference: SNOMEDCT_US:406756000

Tetrapyrroles
type: Class
subclass of: Heterocyclic Compounds, 4 or More Rings
subclass of: Macrocyclic Compounds
MCID: MC00039099
PMOID: PMO:00018050
Subclass_of: Heterocyclic Compounds, 4 or More Rings
Subclass_of: Macrocyclic Compounds
Synonym: Tetrapyrrole
Synonym: Tetrapyrrole (substance)
Synonym: Tetrapyrroles [Chemical/Ingredient]
Synonym: tetrapyrrole
Tree Number: T6.3.1.3.12
Tree Number: T6.4.5.6
database_cross_reference: CSP:2520-9644
database_cross_reference: LCH_NW:sh85134221
database_cross_reference: MSH:D045725
database_cross_reference: NDFRT:N0000011329
database_cross_reference: SNOMEDCT_US:418677006

Bile Pigments
type: Class
subclass of: Tetrapyrroles
subclass of: PMO:00024379
MCID: MC00001720
PMOID: PMO:00018051
Subclass_of: Pigments, Biological
Subclass_of: Tetrapyrroles
Synonym: Bile Pigment
Synonym: Bile Pigments [Chemical/Ingredient]
Synonym: Bile pigment
Synonym: Bile pigment (substance)
Synonym: Bile pigment, NOS
Synonym: Bile pigments
Synonym: Pigment, Bile
Synonym: Pigments, Bile
Synonym: bile pigment
Synonym: bile pigments
Tree Number: T6.13.7.3
Tree Number: T6.4.5.6.1
database_cross_reference: CHV:0000001857
database_cross_reference: CSP:0412-2473
database_cross_reference: LCH:U000557
database_cross_reference: LCH_NW:sh85014017
database_cross_reference: MSH:D001654
database_cross_reference: NCI:C304
database_cross_reference: NDFRT:N0000007708
database_cross_reference: RCD:X80Mu
database_cross_reference: SNM:F-15050
database_cross_reference: SNMI:F-65050
database_cross_reference: SNOMEDCT_US:32138006

Bilirubin
type: Class
subclass of: Bile Pigments
MCID: MC00001733
PMOID: PMO:00018052
Subclass_of: Bile Pigments
Synonym: 21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-
Synonym: BILIRUBIN
Synonym: Bilirubin (substance)
Synonym: Bilirubin IX alpha
Synonym: Bilirubin [Chemical/Ingredient]
Synonym: Bilirubin, NOS
Synonym: Bilirubin, total
Synonym: Conjugated & unconjugated bili
Synonym: Conjugated and unconjugated bilirubin
Synonym: Total bilirubin
Tree Number: T6.13.7.3.1
database_cross_reference: AOD:0000020831
database_cross_reference: CCPSS:1001672
database_cross_reference: CHV:0000001867
database_cross_reference: CSP:0412-2941
database_cross_reference: LCH:U000560
database_cross_reference: LCH_NW:sh85014033
database_cross_reference: LNC:LP15448-1
database_cross_reference: LNC:MTHU002437
database_cross_reference: MSH:D001663
database_cross_reference: MTH:U000253
database_cross_reference: MTH:U000254
database_cross_reference: MTH:U000287
database_cross_reference: MTH:U000340
database_cross_reference: MTH:U000342
database_cross_reference: MTH:U000370
database_cross_reference: MTH:U001738
database_cross_reference: NCI:C305
database_cross_reference: NCI_DTP:NSC0026671
database_cross_reference: NCI_DTP:NSC0026685
database_cross_reference: NCI_FDA:RFM9X3LJ49
database_cross_reference: NCI_NCI-GLOSS:CDR0000044518
database_cross_reference: NDFRT:N0000006844
database_cross_reference: RCD:X79be
database_cross_reference: SNM:F-15000
database_cross_reference: SNMI:F-65000
database_cross_reference: SNOMEDCT_US:79706000

Urobilin
type: Class
subclass of: Bile Pigments
MCID: MC00013388
PMOID: PMO:00018054
Subclass_of: Bile Pigments
Synonym: 21H-Biline-8,12-dipropanoic acid, 3,18-diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-
Synonym: Urobilin (substance)
Synonym: Urobilin [Chemical/Ingredient]
Synonym: urobilin
Tree Number: T6.13.7.3.2
database_cross_reference: AOD:0000020833
database_cross_reference: CHV:0000012798
database_cross_reference: CSP:0412-2473
database_cross_reference: LCH:U004868
database_cross_reference: LCH_NW:sh85141438
database_cross_reference: LNC:LP15941-5
database_cross_reference: LNC:MTHU014622
database_cross_reference: MSH:D014557
database_cross_reference: NDFRT:N0000171216
database_cross_reference: RCD:X80NM
database_cross_reference: SNM:F-15120
database_cross_reference: SNMI:F-65120
database_cross_reference: SNOMEDCT_US:75635009

Urobilinogen
type: Class
subclass of: Bile Pigments
MCID: MC00013389
PMOID: PMO:00018055
Subclass_of: Bile Pigments
Synonym: 21H-Biline-8,12-dipropanoic acid, 2,17-diethyl-1,4,5,10,15,16,19,22,23,24-decahydro-3,7,13,18-tetramethyl-1,19-dioxo-
Synonym: UBG - Urobilinogen
Synonym: UROB - Urobilinogen
Synonym: Urobilinogen (substance)
Synonym: Urobilinogen [Chemical/Ingredient]
Synonym: Urobilinogen, NOS
Synonym: urobilinogen
Synonym: urobilinogens
Tree Number: T6.13.7.3.3
database_cross_reference: AOD:0000020834
database_cross_reference: CHV:0000012799
database_cross_reference: LNC:LP15942-3
database_cross_reference: LNC:MTHU003204
database_cross_reference: MSH:D014558
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000369
database_cross_reference: NDFRT:N0000007137
database_cross_reference: RCD:X80NN
database_cross_reference: SNM:F-15110
database_cross_reference: SNMI:F-65110
database_cross_reference: SNOMEDCT_US:44079009

Chlorophyll
type: Class
subclass of: Tetrapyrroles
MCID: MC00002671
PMOID: PMO:00018056
Subclass_of: Tetrapyrroles
Synonym: CHLOROPHYLL
Synonym: Chlorophyll (substance)
Synonym: Chlorophyll [Chemical/Ingredient]
Synonym: Chlorophylls
Synonym: chlorophyll
Synonym: chlorophylls
Tree Number: T6.4.5.6.2
database_cross_reference: CHV:0000002834
database_cross_reference: CSP:2386-4255
database_cross_reference: DRUGBANK:DB02133
database_cross_reference: LCH:U000978
database_cross_reference: LCH_NW:sh85024579
database_cross_reference: MMSL:11074
database_cross_reference: MSH:D002734
database_cross_reference: MTHSPL:00WNZ48OR9
database_cross_reference: NCI:C366
database_cross_reference: NCI_DCP:30130
database_cross_reference: NDFRT:N0000006912
database_cross_reference: NDFRT:N0000147223
database_cross_reference: RXNORM:2388
database_cross_reference: SNM:E-7110
database_cross_reference: SNMI:C-30710
database_cross_reference: SNOMEDCT_US:14602007
database_cross_reference: VANDF:4018931

Bacteriochlorophylls
type: Class
subclass of: PMO:00023861
MCID: MC00001478
PMOID: PMO:00018057
Subclass_of: Photoreceptors, Microbial
Synonym: Bacteriochlorophyll
Synonym: Bacteriochlorophyll (substance)
Synonym: Bacteriochlorophyll -RETIRED-
Synonym: Bacteriochlorophylls [Chemical/Ingredient]
Tree Number: T6.10.3.68.1
database_cross_reference: MSH:D001429
database_cross_reference: NDFRT:N0000171204
database_cross_reference: SNMI:C-36014
database_cross_reference: SNOMEDCT_US:123043002
database_cross_reference: SNOMEDCT_US:7318002

Porphyrins
type: Class
subclass of: Tetrapyrroles
subclass of: PMO:00024379
MCID: MC00010496
PMOID: PMO:00018061
Subclass_of: Pigments, Biological
Subclass_of: Tetrapyrroles
Synonym: Porphyrin
Synonym: Porphyrin (substance)
Synonym: Porphyrin, NOS
Synonym: Porphyrins [Chemical/Ingredient]
Synonym: porphyrin
Synonym: porphyrins
Tree Number: T6.13.7.13
Tree Number: T6.4.5.6.3
database_cross_reference: AOD:0000001945
database_cross_reference: CHV:0000009973
database_cross_reference: CSP:2386-3893
database_cross_reference: LCH_NW:sh85105022
database_cross_reference: LNC:LP14913-5
database_cross_reference: LNC:MTHU002171
database_cross_reference: MSH:D011166
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C764
database_cross_reference: NDFRT:N0000007865
database_cross_reference: RCD:X80SC
database_cross_reference: SNM:F-14800
database_cross_reference: SNM:U000190
database_cross_reference: SNMI:F-64800
database_cross_reference: SNOMEDCT_US:15730005

Coproporphyrins
type: Class
subclass of: Porphyrins
MCID: MC00003253
PMOID: PMO:00018062
Subclass_of: Porphyrins
Synonym: Coproporphryrin
Synonym: Coproporphyrin
Synonym: Coproporphyrin (substance)
Synonym: Coproporphyrins [Chemical/Ingredient]
Synonym: coproporphyrin
Synonym: coproporphyrins
Tree Number: T6.13.7.13.1
database_cross_reference: CHV:0000003345
database_cross_reference: LNC:LP15151-1
database_cross_reference: LNC:MTHU002536
database_cross_reference: MSH:D003306
database_cross_reference: NDFRT:N0000171203
database_cross_reference: RCD:X80UL
database_cross_reference: SNM:F-14920
database_cross_reference: SNMI:F-64920
database_cross_reference: SNOMEDCT_US:51598008

Deuteroporphyrins
type: Class
subclass of: Porphyrins
MCID: MC00003758
PMOID: PMO:00018063
Subclass_of: Porphyrins
Synonym: Deuteroporphyrins [Chemical/Ingredient]
Tree Number: T6.13.7.13.2
database_cross_reference: MSH:D003905
database_cross_reference: NDFRT:N0000171201

Etioporphyrins
type: Class
subclass of: Porphyrins
MCID: MC00004824
PMOID: PMO:00018064
Subclass_of: Porphyrins
Synonym: Etioporphyrin
Synonym: Etioporphyrin (substance)
Synonym: Etioporphyrins [Chemical/Ingredient]
Tree Number: T6.13.7.13.3
database_cross_reference: MSH:D005044
database_cross_reference: NDFRT:N0000171211
database_cross_reference: SNMI:F-64960
database_cross_reference: SNOMEDCT_US:89829009

Hematoporphyrins
type: Class
subclass of: Porphyrins
MCID: MC00006035
PMOID: PMO:00018065
Subclass_of: Porphyrins
Synonym: Hematoporphyrins [Chemical/Ingredient]
Tree Number: T6.13.7.13.4
database_cross_reference: MSH:D006415
database_cross_reference: NDFRT:N0000171212

Mesoporphyrins
type: Class
subclass of: Porphyrins
MCID: MC00008110
PMOID: PMO:00018068
Subclass_of: Porphyrins
Synonym: Mesoporphyrins [Chemical/Ingredient]
Tree Number: T6.13.7.13.5
database_cross_reference: MSH:D008652
database_cross_reference: NDFRT:N0000171200

Metalloporphyrins
type: Class
subclass of: Porphyrins
MCID: MC00008125
PMOID: PMO:00018069
Subclass_of: Porphyrins
Synonym: Metalloporphyrin
Synonym: Metalloporphyrin (substance)
Synonym: Metalloporphyrin agent
Synonym: Metalloporphyrin agent (substance)
Synonym: Metalloporphyrin preparation
Synonym: Metalloporphyrin preparation (product)
Synonym: Metalloporphyrin preparation (substance)
Synonym: Metalloporphyrin, NOS
Synonym: Metalloporphyrins [Chemical/Ingredient]
Synonym: metalloporphyrin
Tree Number: T6.13.7.13.6
database_cross_reference: CSP:2386-4829
database_cross_reference: MSH:D008665
database_cross_reference: NDFRT:N0000007985
database_cross_reference: SNMI:F-64990
database_cross_reference: SNOMEDCT_US:109026004
database_cross_reference: SNOMEDCT_US:373454003
database_cross_reference: SNOMEDCT_US:57454001

Protoporphyrins
type: Class
subclass of: Porphyrins
MCID: MC00010811
PMOID: PMO:00018075
Subclass_of: Porphyrins
Synonym: Protoporphyrin
Synonym: Protoporphyrin (substance)
Synonym: Protoporphyrins [Chemical/Ingredient]
Synonym: protoporphyrin
Synonym: protoporphyrins
Tree Number: T6.13.7.13.7
database_cross_reference: AOD:0000020829
database_cross_reference: CHV:0000010264
database_cross_reference: DRUGBANK:DB02285
database_cross_reference: LNC:LP15839-1
database_cross_reference: LNC:MTHU004691
database_cross_reference: MSH:D011524
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:006951
database_cross_reference: NDFRT:N0000171210
database_cross_reference: RCD:X80LG
database_cross_reference: SNM:F-14930
database_cross_reference: SNMI:F-64930
database_cross_reference: SNOMEDCT_US:51866008

Uroporphyrins
type: Class
subclass of: Porphyrins
MCID: MC00013404
PMOID: PMO:00018076
Subclass_of: Porphyrins
Synonym: Uroporphyrin
Synonym: Uroporphyrin (substance)
Synonym: Uroporphyrins [Chemical/Ingredient]
Synonym: uroporphyrins
Tree Number: T6.13.7.13.8
database_cross_reference: AOD:0000020830
database_cross_reference: LNC:LP15161-0
database_cross_reference: LNC:MTHU002550
database_cross_reference: MSH:D014578
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171202
database_cross_reference: RCD:Xa9pm
database_cross_reference: SNM:F-14910
database_cross_reference: SNMI:F-64910
database_cross_reference: SNOMEDCT_US:55170008

Corrinoids
type: Class
subclass of: Tetrapyrroles
MCID: MC00420890
PMOID: PMO:00018077
Subclass_of: Tetrapyrroles
Synonym: Corrinoid
Synonym: Corrinoid (substance)
Synonym: Corrinoids [Chemical/Ingredient]
Synonym: corrinoid
Tree Number: T6.4.5.6.4
database_cross_reference: CSP:3144-1115
database_cross_reference: LCH_NW:sh2006004546
database_cross_reference: MSH:D045728
database_cross_reference: NDFRT:N0000011328
database_cross_reference: SNOMEDCT_US:419584000

Cobamides
type: Class
subclass of: Coenzymes
MCID: MC00003015
PMOID: PMO:00018079
Subclass_of: Coenzymes
Synonym: B12 Coenzymes, Vitamin
Synonym: Cobamides [Chemical/Ingredient]
Synonym: Coenzymes, Vitamin B12
Synonym: Deoxyadenosinecobalamins
Synonym: VITAMIN B A 12 COENZYMES
Synonym: Vitamin B 12 Coenzymes
Synonym: Vitamin B12 Coenzymes
Synonym: cobamide
Synonym: cobamides
Tree Number: T6.7.1.3
database_cross_reference: AOD:0000018246
database_cross_reference: CSP:3144-2052
database_cross_reference: MSH:D003038
database_cross_reference: MTH:U001820
database_cross_reference: NDFRT:N0000168399

Phycobilins
type: Class
subclass of: Tetrapyrroles
MCID: MC00583125
PMOID: PMO:00018081
Subclass_of: Tetrapyrroles
Synonym: Phycobilins [Chemical/Ingredient]
Synonym: phycobilin
Tree Number: T6.4.5.6.5
database_cross_reference: CSP:2447-5000
database_cross_reference: LCH_NW:sh85101464
database_cross_reference: MSH:D052980
database_cross_reference: NDFRT:N0000175105

Acids, Heterocyclic
type: Class
subclass of: Heterocyclic Compounds
MCID: MC00000248
PMOID: PMO:00018082
Subclass_of: Heterocyclic Compounds
Synonym: Acids, Heterocyclic [Chemical/Ingredient]
Synonym: Heterocyclic Acids
Synonym: heterocyclic acid
Tree Number: T6.3.2
database_cross_reference: AOD:0000020709
database_cross_reference: MSH:D000147
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007629

Isonicotinic Acids
type: Class
subclass of: Acids, Heterocyclic
subclass of: Pyridines
MCID: MC00007097
PMOID: PMO:00018083
Subclass_of: Acids, Heterocyclic
Subclass_of: Pyridines
Synonym: Acids, Isonicotinic
Synonym: Isonicotinic Acids [Chemical/Ingredient]
Tree Number: T6.3.2.3
Tree Number: T6.3.5.20.12
database_cross_reference: MSH:D007539
database_cross_reference: NDFRT:N0000007955

Ethionamide
type: Class
subclass of: Isonicotinic Acids
MCID: MC00004775
PMOID: PMO:00018084
Subclass_of: Isonicotinic Acids
Synonym: 2-Ethyl-4-pyridinecarbothioamide
Synonym: 2-Ethyl-4-thiopyridylamide
Synonym: 2-Ethylthioisonicotinamide
Synonym: 2-ethylthioisonicotinamide
Synonym: 4-Pyridinecarbothioamide, 2-ethyl-
Synonym: Amidazine
Synonym: ETH
Synonym: ETHIONAMIDE
Synonym: ETP
Synonym: Ethatyl
Tree Number: T6.3.2.3.1
database_cross_reference: ATC:J04AD03
database_cross_reference: CHV:0000004700
database_cross_reference: DRUGBANK:DB00609
database_cross_reference: LNC:LP17271-5
database_cross_reference: LNC:MTHU006675
database_cross_reference: MEDCIN:40360
database_cross_reference: MMSL:4700
database_cross_reference: MMSL:d01100
database_cross_reference: MSH:D005000
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:OAY8ORS3CQ
database_cross_reference: NCI:C47522
database_cross_reference: NCI_FDA:OAY8ORS3CQ
database_cross_reference: NDDF:002851
database_cross_reference: NDFRT:N0000006681
database_cross_reference: NDFRT:N0000146400
database_cross_reference: RXNORM:4127
database_cross_reference: SNM:E-7342
database_cross_reference: SNMI:C-55250
database_cross_reference: SNOMEDCT_US:32800009
database_cross_reference: SNOMEDCT_US:363730006
database_cross_reference: SNOMEDCT_US:414148003
database_cross_reference: USPMG:MTHU000452
database_cross_reference: VANDF:4018059

Nialamide
type: Class
subclass of: Isonicotinic Acids
MCID: MC00008872
PMOID: PMO:00018085
Subclass_of: Isonicotinic Acids
Synonym: 1-(2-(Benzylcarbamoyl)ethyl)-2-isonicotinoylhydrazine
Synonym: 1-[2-(Benzylcarbamoyl)ethyl]-2-isonicotinoylhydrazine
Synonym: 2-(2-(Benzylcarbamoyl)ethyl)hydrazide isonicotinic acid
Synonym: 2-(2-(Benzylcarbamoyl)ethyl)hydrazide, isonicotinic acid
Synonym: 2-(2-(Benzylcarbamyl)ethyl)hydrazide isonicotinic acid
Synonym: 2-[2-(Benzylcarbamoyl)ethyl]hydrazide isonicotinic acid
Synonym: 4-Pyridinecarboxylic acid, 2-(3-oxo-3-((phenylmethyl)amino)propyl)hydrazide
Synonym: BEIH
Synonym: Delmoneurina
Synonym: Espril
Tree Number: T6.3.2.3.4
database_cross_reference: ATC:N06AF02
database_cross_reference: DRUGBANK:DB04820
database_cross_reference: MSH:D009526
database_cross_reference: MTHSPL:T2Q0RYM725
database_cross_reference: NCI:C80970
database_cross_reference: NCI_FDA:T2Q0RYM725
database_cross_reference: NDDF:001494
database_cross_reference: NDFRT:N0000167319
database_cross_reference: PSY:33990
database_cross_reference: RXNORM:7394
database_cross_reference: SNM:E-7929
database_cross_reference: SNMI:C-62135
database_cross_reference: SNOMEDCT_US:49313009

Prothionamide
type: Class
subclass of: Isonicotinic Acids
MCID: MC00010802
PMOID: PMO:00018086
Subclass_of: Isonicotinic Acids
Synonym: 2-Propylpyridine-4-carbothioamide
Synonym: 4-Pyridinecarbothioamide, 2-propyl-
Synonym: PROTIONAMIDE
Synonym: Prothionamide [Chemical/Ingredient]
Synonym: Protionamide
Synonym: Protionamide (product)
Synonym: Protionamide (substance)
Synonym: prothionamide
Synonym: protionamide
Tree Number: T6.3.2.3.5
database_cross_reference: ATC:J04AD01
database_cross_reference: CHV:0000010258
database_cross_reference: DRUGBANK:DB12667
database_cross_reference: LNC:LP113731-6
database_cross_reference: LNC:MTHU037744
database_cross_reference: MSH:D011515
database_cross_reference: NCI:C72605
database_cross_reference: NCI_FDA:76YOO33643
database_cross_reference: NDDF:006706
database_cross_reference: NDFRT:N0000167317
database_cross_reference: RXNORM:8871
database_cross_reference: SNOMEDCT_US:703589003
database_cross_reference: SNOMEDCT_US:714517006

Pyridoxic Acid
type: Class
subclass of: Isonicotinic Acids
MCID: MC00011004
PMOID: PMO:00018087
Subclass_of: Isonicotinic Acids
Synonym: 4 Pyridoxic Acid
Synonym: 4 Pyridoxinic Acid
Synonym: 4 Pyridoxylic Acid
Synonym: 4-Pyridinecarboxylic acid, 3-hydroxy-5-(hydroxymethyl)-2-methyl-
Synonym: 4-Pyridoxic Acid
Synonym: 4-Pyridoxic acid
Synonym: 4-Pyridoxic acid (substance)
Synonym: 4-Pyridoxinic Acid
Synonym: 4-Pyridoxylic Acid
Synonym: Pyridoxic Acid [Chemical/Ingredient]
Tree Number: T6.3.2.3.6
database_cross_reference: MSH:D011735
database_cross_reference: NDFRT:N0000167318
database_cross_reference: SNMI:F-618B0
database_cross_reference: SNOMEDCT_US:102658006

Isonipecotic Acids
type: Class
subclass of: Acids, Heterocyclic
subclass of: Piperidines
MCID: MC00007098
PMOID: PMO:00018088
Subclass_of: Acids, Heterocyclic
Subclass_of: Piperidines
Synonym: Acids, Isonipecotic
Synonym: Isonipecotic Acids [Chemical/Ingredient]
Tree Number: T6.3.2.4
Tree Number: T6.3.5.16.11
database_cross_reference: MSH:D007540
database_cross_reference: NDFRT:N0000007958

Diphenoxylate
type: Class
subclass of: Isonipecotic Acids
MCID: MC00004005
PMOID: PMO:00018089
Subclass_of: Isonipecotic Acids
Synonym: 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester
Synonym: 2,2-Diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile
Synonym: 4-Ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile
Synonym: 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester
Synonym: DIPHENOXYLATE
Synonym: Difenossilato
Synonym: Difenoxilato
Synonym: Diphenoxylate (product)
Synonym: Diphenoxylate (substance)
Synonym: Diphenoxylate Hcl and Atropine Sulfate
Tree Number: T6.3.2.4.1
database_cross_reference: ATC:A07DA01
database_cross_reference: CHV:0000003983
database_cross_reference: DRUGBANK:DB01081
database_cross_reference: LNC:LP18090-8
database_cross_reference: LNC:MTHU003372
database_cross_reference: MMSL:d03071
database_cross_reference: MSH:D004157
database_cross_reference: MTHSPL:73312P173G
database_cross_reference: NCI:C62024
database_cross_reference: NCI_FDA:73312P173G
database_cross_reference: NDDF:004544
database_cross_reference: NDFRT:N0000006800
database_cross_reference: NDFRT:N0000147818
database_cross_reference: RCD:a82..
database_cross_reference: RXNORM:3500
database_cross_reference: SNM:E-8234
database_cross_reference: SNMI:C-84510
database_cross_reference: SNOMEDCT_US:15052009
database_cross_reference: SNOMEDCT_US:317360000
database_cross_reference: SNOMEDCT_US:440585000
database_cross_reference: VANDF:4019726

Meperidine
type: Class
subclass of: Isonipecotic Acids
MCID: MC00008076
PMOID: PMO:00018090
Subclass_of: Isonipecotic Acids
Synonym: 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester
Synonym: Demerol 50mg - Liq Im IV Sc 50mg/ml
Synonym: Demerol 50mg - Liq Im Sc 50mg/ml
Synonym: Demerol 10%-liq Im IV Sc
Synonym: Demerol 10%-liq Im Sc 100mg/ml
Synonym: Demerol 100 mg/ml
Synonym: Demerol 50 mg/ml (multiple Dose With Metacresol As Preservative)
Synonym: Demerol 50 mg/ml (single Use, Preservative Free)
Synonym: Demerol 75 mg/ml
Synonym: Demerol 75mg - Liq Im IV Sc 75mg/ml
Tree Number: T6.3.2.4.2
database_cross_reference: AOD:0000020574
database_cross_reference: AOD:0000028988
database_cross_reference: ATC:N02AB02
database_cross_reference: CCPSS:1003408
database_cross_reference: CHV:0000007969
database_cross_reference: CSP:2332-4177
database_cross_reference: DRUGBANK:DB00454
database_cross_reference: LNC:LP16184-1
database_cross_reference: LNC:MTHU005014
database_cross_reference: MEDCIN:340441
database_cross_reference: MMSL:d00017
database_cross_reference: MSH:D008614
database_cross_reference: MTHSPL:9E338QE28F
database_cross_reference: NCI:C71632
database_cross_reference: NCI_FDA:9E338QE28F
database_cross_reference: NDDF:004620
database_cross_reference: NDFRT:N0000006387
database_cross_reference: NDFRT:N0000147902
database_cross_reference: PSY:30900
database_cross_reference: RCD:x01Kn
database_cross_reference: RXNORM:6754
database_cross_reference: SNM:E-7795
database_cross_reference: SNMI:C-60690
database_cross_reference: SNOMEDCT_US:387298007
database_cross_reference: SNOMEDCT_US:54544005
database_cross_reference: USPMG:MTHU000025
database_cross_reference: VANDF:4019813

Phenoperidine
type: Class
subclass of: Isonipecotic Acids
MCID: MC00010025
PMOID: PMO:00018092
Subclass_of: Isonipecotic Acids
Synonym: 4-Piperidinecarboxylic acid, 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-, ethyl ester
Synonym: Fenoperidine
Synonym: PHENOPERIDINE
Synonym: Phenoperidine (product)
Synonym: Phenoperidine (substance)
Synonym: Phenoperidine [Chemical/Ingredient]
Synonym: phenoperidine
Tree Number: T6.3.2.4.3
database_cross_reference: ATC:N01AH04
database_cross_reference: MSH:D010638
database_cross_reference: NCI:C72123
database_cross_reference: NCI_FDA:G9BH09J4JW
database_cross_reference: NDDF:004020
database_cross_reference: NDFRT:N0000167337
database_cross_reference: RCD:x01Ko
database_cross_reference: RXNORM:8143
database_cross_reference: SNOMEDCT_US:350306009
database_cross_reference: SNOMEDCT_US:420076001

Pirinitramide
type: Class
subclass of: Isonipecotic Acids
MCID: MC00010247
PMOID: PMO:00018093
Subclass_of: Isonipecotic Acids
Synonym: (1,4'-Bipiperidine)-4'-carboxamide, 1'-(3-Cyano-3,3-diphenylpropyl)
Synonym: (1,4'-Bipiperidine)-4'-carboxamide, 1'-(3-cyano-3,3-diphenylpropyl)-
Synonym: 1'-(3-Cyano-3,3-diphenylpropyl)-(1,4'-bipiperidine)-4'-carboxamide
Synonym: PIRITRAMIDE
Synonym: Pirinitramide [Chemical/Ingredient]
Synonym: Piritramid
Synonym: Piritramide
Synonym: Piritramide (substance)
Synonym: R 3365
Synonym: pirinitramide
Tree Number: T6.3.2.4.4
database_cross_reference: ATC:N02AC03
database_cross_reference: CHV:0000009754
database_cross_reference: DRUGBANK:DB12492
database_cross_reference: MSH:D010892
database_cross_reference: NCI:C119750
database_cross_reference: NCI_FDA:4RP92LYZ2F
database_cross_reference: NDDF:006892
database_cross_reference: NDFRT:N0000167338
database_cross_reference: RXNORM:8354
database_cross_reference: SNOMEDCT_US:707837002

Nicotinic Acids
type: Class
subclass of: Acids, Heterocyclic
subclass of: Pyridines
MCID: MC00008889
PMOID: PMO:00018094
Subclass_of: Acids, Heterocyclic
Subclass_of: Pyridines
Synonym: Acids, Nicotinic
Synonym: Nicotinic Acids [Chemical/Ingredient]
Synonym: acid nicotinic
Synonym: nicotinic acid
Tree Number: T6.3.2.5
Tree Number: T6.3.5.20.16
database_cross_reference: AOD:0000020524
database_cross_reference: CHV:0000008710
database_cross_reference: MSH:D009539
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007641

Arecoline
type: Class
subclass of: Nicotinic Acids
subclass of: Alkaloids
MCID: MC00001218
PMOID: PMO:00018095
Subclass_of: Alkaloids
Subclass_of: Nicotinic Acids
Synonym: 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester
Synonym: ARECOLINE
Synonym: Arecaline
Synonym: Arecholin
Synonym: Arecholine
Synonym: Arecolin
Synonym: Arecoline (substance)
Synonym: Arecoline [Chemical/Ingredient]
Synonym: Methylarecaidin
Synonym: arecaline
Tree Number: T6.3.2.5.1
Tree Number: T6.3.3.3
database_cross_reference: AOD:0000000831
database_cross_reference: AOD:0000000832
database_cross_reference: AOD:0000021382
database_cross_reference: CHV:0000001421
database_cross_reference: CSP:2509-6845
database_cross_reference: DRUGBANK:DB04365
database_cross_reference: MSH:D001115
database_cross_reference: NCI:C76610
database_cross_reference: NCI_FDA:4ALN5933BH
database_cross_reference: NDFRT:N0000167324
database_cross_reference: PSY:03690
database_cross_reference: SNM:E-6863
database_cross_reference: SNMI:C-30381
database_cross_reference: SNOMEDCT_US:2995003

Clonixin
type: Class
subclass of: Nicotinic Acids
MCID: MC00002971
PMOID: PMO:00018096
Subclass_of: Nicotinic Acids
Synonym: 3-Pyridinecarboxylic acid, 2-((3-chloro-2-methylphenyl)amino)-
Synonym: CLONIXIN
Synonym: Clonixin [Chemical/Ingredient]
Synonym: clonixin
Tree Number: T6.3.2.5.2
database_cross_reference: CHV:0000003060
database_cross_reference: DRUGBANK:DB09218
database_cross_reference: MSH:D003002
database_cross_reference: NCI:C65340
database_cross_reference: NCI_FDA:V7DXN0M42R
database_cross_reference: NDDF:004344
database_cross_reference: NDFRT:N0000167333
database_cross_reference: RXNORM:2601

Etazolate
type: Class
subclass of: Nicotinic Acids
MCID: MC00004753
PMOID: PMO:00018097
Subclass_of: Nicotinic Acids
Synonym: 1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester
Synonym: ETAZOLATE
Synonym: Etazolate [Chemical/Ingredient]
Tree Number: T6.3.2.5.3
database_cross_reference: MSH:D004974
database_cross_reference: NCI:C73334
database_cross_reference: NCI_FDA:I89Y79062L
database_cross_reference: NDFRT:N0000167331

Niacin
type: Class
subclass of: Nicotinic Acids
MCID: MC00008871
PMOID: PMO:00018098
Subclass_of: Nicotinic Acids
Synonym: 3 Pyridinecarboxylic Acid
Synonym: 3-Pyridinecarboxylic Acid
Synonym: 3-Pyridinecarboxylic acid
Synonym: 3-Pyridylcarboxylic acid
Synonym: 3-carboxypyridine
Synonym: Acide Nicotinique
Synonym: Acido nicotinico
Synonym: Acidum Nicotinicum
Synonym: Acti-niacin Caplet 500mg
Synonym: American Eagle Energizer Plus Vitamin Supplement Drink
Tree Number: T6.3.2.5.4
database_cross_reference: AOD:0000004764
database_cross_reference: ATC:C04AC01
database_cross_reference: ATC:C10AD02
database_cross_reference: CHV:0000008699
database_cross_reference: CSP:3147-2013
database_cross_reference: DRUGBANK:DB00627
database_cross_reference: LCH:U003226
database_cross_reference: LCH_NW:sh85091698
database_cross_reference: LNC:LP14887-1
database_cross_reference: LNC:MTHU002113
database_cross_reference: MEDCIN:41282
database_cross_reference: MEDCIN:41284
database_cross_reference: MEDCIN:78886
database_cross_reference: MEDLINEPLUS:5376
database_cross_reference: MMSL:2275
database_cross_reference: MMSL:5169
database_cross_reference: MMSL:7161
database_cross_reference: MMSL:d00314
database_cross_reference: MSH:D009525
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2679MF687A
database_cross_reference: NCI:C689
database_cross_reference: NCI_CRCH:C689
database_cross_reference: NCI_DCP:06743
database_cross_reference: NCI_DTP:NSC0015010
database_cross_reference: NCI_DTP:NSC0169454
database_cross_reference: NCI_FDA:2679MF687A
database_cross_reference: NCI_NCI-GLOSS:CDR0000556407
database_cross_reference: NCI_NCI-GLOSS:CDR0000629154
database_cross_reference: NDDF:001052
database_cross_reference: NDFRT:N0000006449
database_cross_reference: NDFRT:N0000146039
database_cross_reference: NDFRT:N0000147570
database_cross_reference: PDQ:CDR0000038351
database_cross_reference: PSY:33970
database_cross_reference: PSY:34020
database_cross_reference: RCD:XM0l0
database_cross_reference: RCD:bx8..
database_cross_reference: RXNORM:7393
database_cross_reference: SNM:E-8777
database_cross_reference: SNM:F-16330
database_cross_reference: SNMI:C-A4420
database_cross_reference: SNMI:F-BB430
database_cross_reference: SNOMEDCT_US:273943001
database_cross_reference: SNOMEDCT_US:419923002
database_cross_reference: SNOMEDCT_US:55013001
database_cross_reference: SNOMEDCT_US:63639004
database_cross_reference: USPMG:MTHU001014
database_cross_reference: VANDF:4017661
database_cross_reference: VANDF:4019440

Niceritrol
type: Class
subclass of: Nicotinic Acids
MCID: MC00008877
PMOID: PMO:00018099
Subclass_of: Nicotinic Acids
Synonym: 3-Pyridinecarboxylic acid, 2,2-bis(((3-pyridinylcarbonyl)oxy)methyl)-1,3-propanediyl ester
Synonym: NICERITROL
Synonym: Niceritrol [Chemical/Ingredient]
Synonym: Pentaerythritol Tetranicotinate
Synonym: Pentaerythritoltetranicotinate
Synonym: Tetranicotinate, Pentaerythritol
Synonym: niceritrol
Tree Number: T6.3.2.5.5
database_cross_reference: ATC:C10AD01
database_cross_reference: MSH:D009531
database_cross_reference: NCI:C75257
database_cross_reference: NCI_FDA:F54EHJ34MV
database_cross_reference: NDFRT:N0000167332

Niacinamide
type: Class
subclass of: Nicotinic Acids
MCID: MC00008883
PMOID: PMO:00018100
Subclass_of: Nicotinic Acids
Synonym: 3 Pyridinecarboxamide
Synonym: 3-Pyridinecarboxamide
Synonym: A.H.C. C-cream
Synonym: A.H.C. C-serum
Synonym: A.H.C. C-toner
Synonym: A.H.c Cotton 100 Mask Multi Peptide
Synonym: A.H.c Cotton 100 Mask Skin Ceramide
Synonym: A.H.c Cotton 100 Mask Soy Isoflavone
Synonym: A.H.c Cotton 100 Mask Triple Hyaluronic
Synonym: ABALONE CrystalDouble EX
Tree Number: T6.3.2.5.6
database_cross_reference: AOD:0000020528
database_cross_reference: ATC:A11HA01
database_cross_reference: CHV:0000008706
database_cross_reference: CSP:3147-2196
database_cross_reference: CSP:3147-2379
database_cross_reference: DRUGBANK:DB02701
database_cross_reference: LCH_NW:sh85144000
database_cross_reference: LNC:LP16218-7
database_cross_reference: LNC:MTHU007481
database_cross_reference: MEDCIN:41283
database_cross_reference: MMSL:4947
database_cross_reference: MMSL:5170
database_cross_reference: MMSL:5684
database_cross_reference: MMSL:72420
database_cross_reference: MMSL:d03739
database_cross_reference: MSH:D009536
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:25X51I8RD4
database_cross_reference: NCI:C2327
database_cross_reference: NCI:C689
database_cross_reference: NCI_DCP:02180
database_cross_reference: NCI_DTP:NSC0027452
database_cross_reference: NCI_FDA:25X51I8RD4
database_cross_reference: NCI_NCI-GLOSS:CDR0000044441
database_cross_reference: NCI_NCI-GLOSS:CDR0000045416
database_cross_reference: NCI_NCI-GLOSS:CDR0000629155
database_cross_reference: NDDF:001055
database_cross_reference: NDFRT:N0000006493
database_cross_reference: NDFRT:N0000146012
database_cross_reference: NDFRT:N0000146087
database_cross_reference: NDFRT:N0000148162
database_cross_reference: PDQ:CDR0000038351
database_cross_reference: PDQ:CDR0000042044
database_cross_reference: PSY:33980
database_cross_reference: PSY:34000
database_cross_reference: PSY:34030
database_cross_reference: RCD:X80RK
database_cross_reference: RCD:in1..
database_cross_reference: RCD:m6C..
database_cross_reference: RXNORM:7405
database_cross_reference: SNM:E-8781
database_cross_reference: SNM:F-16330
database_cross_reference: SNM:F-16340
database_cross_reference: SNM:F-16350
database_cross_reference: SNMI:C-A4421
database_cross_reference: SNMI:F-BB430
database_cross_reference: SNMI:F-BB440
database_cross_reference: SNMI:F-BB450
database_cross_reference: SNOMEDCT_US:173196005
database_cross_reference: SNOMEDCT_US:259657008
database_cross_reference: SNOMEDCT_US:332374008
database_cross_reference: SNOMEDCT_US:55013001
database_cross_reference: SNOMEDCT_US:58527004
database_cross_reference: SNOMEDCT_US:61650007
database_cross_reference: SNOMEDCT_US:86431009
database_cross_reference: VANDF:4017632
database_cross_reference: VANDF:4017718
database_cross_reference: VANDF:4020285

Pipemidic Acid
type: Class
subclass of: Nicotinic Acids
subclass of: Piperazines
MCID: MC00010230
PMOID: PMO:00018103
Subclass_of: Nicotinic Acids
Subclass_of: Piperazines
Synonym: Acid, Pipemidic
Synonym: Acid, Piperamic
Synonym: PIPEMIDIC ACID
Synonym: Pipemidic Acid [Chemical/Ingredient]
Synonym: Pipemidic acid
Synonym: Pipemidic acid (product)
Synonym: Pipemidic acid (substance)
Synonym: Piperamic Acid
Synonym: Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-
Synonym: pipemidic acid
Tree Number: T6.3.2.5.8
Tree Number: T6.3.5.15.21
database_cross_reference: ATC:J01MB04
database_cross_reference: MEDCIN:198681
database_cross_reference: MSH:D010876
database_cross_reference: NCI:C66394
database_cross_reference: NCI_FDA:LT12J5HVR8
database_cross_reference: NDDF:004201
database_cross_reference: NDFRT:N0000167334
database_cross_reference: RXNORM:8337
database_cross_reference: SNMI:C-55728
database_cross_reference: SNOMEDCT_US:702807004
database_cross_reference: SNOMEDCT_US:96079005

Piromidic Acid
type: Class
subclass of: Nicotinic Acids
MCID: MC00010248
PMOID: PMO:00018104
Subclass_of: Nicotinic Acids
Synonym: Acid, Piromidic
Synonym: PIROMIDIC ACID
Synonym: Piromidic Acid [Chemical/Ingredient]
Synonym: Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-pyrrolidinyl)-
Synonym: piromidic acid
Tree Number: T6.3.2.5.9
database_cross_reference: ATC:J01MB03
database_cross_reference: MSH:D010893
database_cross_reference: NCI:C66433
database_cross_reference: NCI_FDA:3I12WH4EWF
database_cross_reference: NDFRT:N0000167325

Nipecotic Acids
type: Class
subclass of: Acids, Heterocyclic
subclass of: Piperidines
MCID: MC00008910
PMOID: PMO:00018105
Subclass_of: Acids, Heterocyclic
Subclass_of: Piperidines
Synonym: Acids, Nipecotic
Synonym: Nipecotic Acids [Chemical/Ingredient]
Tree Number: T6.3.2.6
Tree Number: T6.3.5.16.19
database_cross_reference: MSH:D009557
database_cross_reference: NDFRT:N0000007644

Orotic Acid
type: Class
subclass of: Acids, Heterocyclic
MCID: MC00009254
PMOID: PMO:00018106
Subclass_of: Acids, Heterocyclic
Synonym: 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-
Synonym: Acid, Orotic
Synonym: OROTIC ACID
Synonym: Orotic Acid [Chemical/Ingredient]
Synonym: Orotic acid
Synonym: Orotic acid (substance)
Synonym: orotic acid
Tree Number: T6.3.2.7
database_cross_reference: CHV:0000009039
database_cross_reference: DRUGBANK:DB02262
database_cross_reference: LCH_NW:sh89003692
database_cross_reference: MSH:D009963
database_cross_reference: MTHSPL:61H4T033E5
database_cross_reference: NCI:C81628
database_cross_reference: NCI_FDA:61H4T033E5
database_cross_reference: NDDF:006148
database_cross_reference: NDFRT:N0000167335
database_cross_reference: RCD:X80HG
database_cross_reference: RXNORM:7712
database_cross_reference: SNM:F-11370
database_cross_reference: SNMI:F-61370
database_cross_reference: SNOMEDCT_US:2254005

Picolinic Acids
type: Class
subclass of: Acids, Heterocyclic
subclass of: Pyridines
MCID: MC00010206
PMOID: PMO:00018107
Subclass_of: Acids, Heterocyclic
Subclass_of: Pyridines
Synonym: Acids, Picolinic
Synonym: Picolinic Acids [Chemical/Ingredient]
Tree Number: T6.3.2.8
Tree Number: T6.3.5.20.20
database_cross_reference: MSH:D010848
database_cross_reference: NDFRT:N0000011168

Fusaric Acid
type: Class
subclass of: Picolinic Acids
MCID: MC00005360
PMOID: PMO:00018108
Subclass_of: Picolinic Acids
Synonym: 2-Pyridinecarboxylic acid, 5-butyl-
Synonym: 5 Butyl 2 pyridinedicarboxylic Acid
Synonym: 5-Butyl-2-pyridinedicarboxylic Acid
Synonym: Acid, 5-Butyl-2-pyridinedicarboxylic
Synonym: Acid, Fusaric
Synonym: Fusaric Acid [Chemical/Ingredient]
Tree Number: T6.3.2.8.1
database_cross_reference: MSH:D005669
database_cross_reference: NDFRT:N0000167321

Picloram
type: Class
subclass of: Picolinic Acids
MCID: MC00010203
PMOID: PMO:00018109
Subclass_of: Picolinic Acids
Synonym: 2-Pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-
Synonym: Chloramp
Synonym: Picloram [Chemical/Ingredient]
Tree Number: T6.3.2.8.2
database_cross_reference: LCH_NW:sh87005017
database_cross_reference: LNC:LP19198-8
database_cross_reference: LNC:MTHU007556
database_cross_reference: MSH:D010846
database_cross_reference: NDFRT:N0000167322

Streptonigrin
type: Class
subclass of: Picolinic Acids
MCID: MC00012270
PMOID: PMO:00018110
Subclass_of: Picolinic Acids
Synonym: 2-Pyridinecarboxylic acid, 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-
Synonym: 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid
Synonym: 5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid
Synonym: Brunemycin
Synonym: Bruneomycin
Synonym: Rufocromomycin
Synonym: STN
Synonym: STREPTONIGRIN
Synonym: Streptonigrin [Chemical/Ingredient]
Synonym: streptonigrin
Tree Number: T6.3.2.8.3
database_cross_reference: CHV:0000011768
database_cross_reference: CSP:0192-4208
database_cross_reference: MSH:D013308
database_cross_reference: MTH:U002270
database_cross_reference: NCI:C844
database_cross_reference: NCI_DCP:31698
database_cross_reference: NCI_DTP:NSC0045383
database_cross_reference: NCI_DTP:NSC0083950
database_cross_reference: NCI_FDA:261Q3JB310
database_cross_reference: NDFRT:N0000167323
database_cross_reference: PDQ:CDR0000039703

Pipecolic Acids
type: Class
subclass of: Acids, Heterocyclic
subclass of: Piperidines
MCID: MC00010229
PMOID: PMO:00018111
Subclass_of: Acids, Heterocyclic
Subclass_of: Piperidines
Synonym: Acids, Pipecolic
Synonym: Pipecolic Acids [Chemical/Ingredient]
Tree Number: T6.3.2.9
Tree Number: T6.3.5.16.24
database_cross_reference: MSH:D010875
database_cross_reference: NDFRT:N0000007925

Xanthurenates
type: Class
subclass of: Acids, Heterocyclic
MCID: MC00013757
PMOID: PMO:00018112
Subclass_of: Acids, Heterocyclic
Synonym: Xanthurenate
Synonym: Xanthurenate (substance)
Synonym: Xanthurenates [Chemical/Ingredient]
Tree Number: T6.3.2.10
database_cross_reference: LNC:LP15954-8
database_cross_reference: LNC:MTHU014703
database_cross_reference: MSH:D014977
database_cross_reference: NDFRT:N0000167314
database_cross_reference: SNOMEDCT_US:706982005

Alkaloids
type: Class
subclass of: Heterocyclic Compounds
MCID: MC00000560
PMOID: PMO:00018113
Subclass_of: Heterocyclic Compounds
Synonym: Alkaloid
Synonym: Alkaloid (substance)
Synonym: Alkaloid, NOS
Synonym: Alkaloids [Chemical/Ingredient]
Synonym: alkaloid
Synonym: alkaloids
Tree Number: T6.3.3
database_cross_reference: AOD:0000020504
database_cross_reference: CHV:0000000899
database_cross_reference: CSP:0091-7950
database_cross_reference: LCH:U000147
database_cross_reference: LCH_NW:sh85003598
database_cross_reference: LNC:LP19581-5
database_cross_reference: MSH:D000470
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C221
database_cross_reference: NCI_NCI-GLOSS:CDR0000043994
database_cross_reference: NDFRT:N0000007503
database_cross_reference: PSY:01820
database_cross_reference: SNM:E-7002
database_cross_reference: SNMI:C-30300
database_cross_reference: SNOMEDCT_US:419001004

Anabasine
type: Class
subclass of: Alkaloids
subclass of: Piperidines
MCID: MC00000842
PMOID: PMO:00018114
Subclass_of: Alkaloids
Subclass_of: Piperidines
Synonym: (-)-2-(3'-Pyridyl)piperidine
Synonym: (S)-3-(2-Piperidinyl)pyridine
Synonym: -(-)-Anabasine
Synonym: 2-(3'-Pyridyl) Piperidine
Synonym: 3-(2-Piperidinyl)pyridine
Synonym: ANABASINE
Synonym: Anabasine (substance)
Synonym: Anabasine [Chemical/Ingredient]
Synonym: L-3-(2'-Piperidyl)pyridine
Synonym: Neonicotine
Tree Number: T6.3.3.2
Tree Number: T6.3.5.16.2
database_cross_reference: CHV:0000001074
database_cross_reference: LNC:LP31704-7
database_cross_reference: LNC:MTHU015758
database_cross_reference: MSH:D000691
database_cross_reference: NCI:C124073
database_cross_reference: NCI_FDA:LMS11II2LO
database_cross_reference: NDFRT:N0000167206
database_cross_reference: SNM:E-6907
database_cross_reference: SNMI:C-32016
database_cross_reference: SNOMEDCT_US:43032004

Camptothecin
type: Class
subclass of: Alkaloids
MCID: MC00002165
PMOID: PMO:00018115
Subclass_of: Alkaloids
Synonym: (+)-Camptothecin
Synonym: (+)-camptothecin
Synonym: (+)-camptothecine
Synonym: (S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione
Synonym: (s)-(+)-camptothecin
Synonym: (s)-camptothecin
Synonym: 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
Synonym: 1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI)
Synonym: 20(S)-Camptothecin
Synonym: 20(S)-Camptothecine
Tree Number: T6.3.3.4
database_cross_reference: CHV:0000002330
database_cross_reference: CSP:0091-9414
database_cross_reference: DRUGBANK:DB04690
database_cross_reference: LCH_NW:sh94006761
database_cross_reference: MEDCIN:195350
database_cross_reference: MSH:D002166
database_cross_reference: NCI:C338
database_cross_reference: NCI_DCP:09054
database_cross_reference: NCI_DTP:NSC0094600
database_cross_reference: NCI_FDA:XT3Z54Z28A
database_cross_reference: NCI_NCI-GLOSS:CDR0000045181
database_cross_reference: NDFRT:N0000007999
database_cross_reference: PDQ:CDR0000039173
database_cross_reference: SNMI:C-30327
database_cross_reference: SNOMEDCT_US:95994003

Topotecan
type: Class
subclass of: Camptothecin
MCID: MC00056857
PMOID: PMO:00018116
Subclass_of: Camptothecin
Synonym: (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
Synonym: 9 Dimethylaminomethyl 10 hydroxycamptothecin
Synonym: 9-Dimethylaminomethyl-10-hydroxycamptothecin
Synonym: 9-[(dimethylamino)Methyl]-10-hydroxy-(4S)-camptothecin
Synonym: 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin
Synonym: Act Topotecan
Synonym: Mylan-topotecan Hydrochloride for Injection
Synonym: PMS-topotecan
Synonym: TOPO
Synonym: TOPOTECAN
Tree Number: T6.3.3.4.1
database_cross_reference: ATC:L01XX17
database_cross_reference: CHV:0000016550
database_cross_reference: CSP:4005-0059
database_cross_reference: DRUGBANK:DB01030
database_cross_reference: LNC:LP172582-1
database_cross_reference: LNC:MTHU046380
database_cross_reference: MMSL:169084
database_cross_reference: MMSL:d04014
database_cross_reference: MSH:D019772
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7M7YKX2N15
database_cross_reference: NCI:C1413
database_cross_reference: NCI_DTP:NSC0641007
database_cross_reference: NCI_FDA:7M7YKX2N15
database_cross_reference: NCI_NCI-GLOSS:CDR0000045342
database_cross_reference: NDDF:005981
database_cross_reference: NDFRT:N0000006832
database_cross_reference: NDFRT:N0000022037
database_cross_reference: PDQ:CDR0000041185
database_cross_reference: RCD:h5F..
database_cross_reference: RXNORM:57308
database_cross_reference: SNOMEDCT_US:108779005
database_cross_reference: SNOMEDCT_US:372536007
database_cross_reference: USPMG:MTHU000524
database_cross_reference: VANDF:4024032

Cinchona Alkaloids
type: Class
subclass of: Alkaloids
PMOID: PMO:00018117
Subclass_of: Alkaloids
Tree Number: T6.3.3.5

Colchicine
type: Class
subclass of: Alkaloids
MCID: MC00003051
PMOID: PMO:00018118
Subclass_of: Alkaloids
Synonym: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Synonym: Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
Synonym: COLCHCINE
Synonym: COLCHICINE
Synonym: Colchicin
Synonym: Colchicina
Synonym: Colchicine (product)
Synonym: Colchicine (substance)
Synonym: Colchicine Tab 1mg
Synonym: Colchicine [Chemical/Ingredient]
Tree Number: T6.3.3.6
database_cross_reference: AOD:0000020511
database_cross_reference: ATC:M04AC01
database_cross_reference: CHV:0000003142
database_cross_reference: CSP:0092-0146
database_cross_reference: DRUGBANK:DB01394
database_cross_reference: LCH_NW:sh92005259
database_cross_reference: LNC:LP18089-0
database_cross_reference: LNC:MTHU003371
database_cross_reference: MEDCIN:345482
database_cross_reference: MEDCIN:40219
database_cross_reference: MMSL:4493
database_cross_reference: MMSL:581
database_cross_reference: MMSL:d00150
database_cross_reference: MSH:D003078
database_cross_reference: MTHSPL:SML2Y3J35T
database_cross_reference: NCI:C385
database_cross_reference: NCI_DCP:02760
database_cross_reference: NCI_DTP:NSC0000757
database_cross_reference: NCI_FDA:SML2Y3J35T
database_cross_reference: NCI_NCI-GLOSS:CDR0000648949
database_cross_reference: NDDF:002372
database_cross_reference: NDFRT:N0000006724
database_cross_reference: NDFRT:N0000145804
database_cross_reference: NDFRT:N0000148412
database_cross_reference: PDQ:CDR0000039188
database_cross_reference: RCD:j62..
database_cross_reference: RXNORM:2683
database_cross_reference: SNM:E-7755
database_cross_reference: SNMI:C-60170
database_cross_reference: SNOMEDCT_US:387413002
database_cross_reference: SNOMEDCT_US:73133000
database_cross_reference: USPMG:MTHU000414
database_cross_reference: VANDF:4017416
database_cross_reference: VANDF:4020930

Demecolcine
type: Class
subclass of: Colchicine
MCID: MC00003607
PMOID: PMO:00018119
Subclass_of: Colchicine
Synonym: (-)-Colchamine
Synonym: Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-
Synonym: Colchamine
Synonym: DEMECOLCINE
Synonym: Demecolcine [Chemical/Ingredient]
Synonym: Methylcolchicine
Synonym: N-Methyl-N-desacetylcolchicine
Synonym: Santavy's Substance F
Synonym: X 153
Synonym: demecolcine
Tree Number: T6.3.3.6.1
database_cross_reference: ATC:L01CC01
database_cross_reference: CSP:0092-0146
database_cross_reference: MSH:D003703
database_cross_reference: NCI:C419
database_cross_reference: NCI_DTP:NSC0403147
database_cross_reference: NCI_FDA:Z01IVE25KI
database_cross_reference: NDFRT:N0000166907

Lumicolchicines
type: Class
subclass of: Colchicine
MCID: MC00007697
PMOID: PMO:00018120
Subclass_of: Colchicine
Synonym: Lumicolchicines [Chemical/Ingredient]
Tree Number: T6.3.3.6.2
database_cross_reference: MSH:D008162
database_cross_reference: NDFRT:N0000166906

Ergot Alkaloids
type: Class
subclass of: Alkaloids
MCID: MC00004650
PMOID: PMO:00018121
Subclass_of: Alkaloids
Synonym: Alkaloids, Clavine
Synonym: Alkaloids, Ergot
Synonym: Clavine Alkaloids
Synonym: Ergot Alkaloids [Chemical/Ingredient]
Synonym: Ergot alkaloid
Synonym: Ergot alkaloid (substance)
Synonym: Ergot alkaloid product
Synonym: Ergot alkaloid product (product)
Synonym: Ergot alkaloid product (substance)
Synonym: Ergot alkaloid, NOS
Tree Number: T6.3.3.9
database_cross_reference: AOD:0000020513
database_cross_reference: ATC:G02AB02
database_cross_reference: CHV:0000004600
database_cross_reference: CSP:0091-7950
database_cross_reference: CSP:0570-1869
database_cross_reference: CSP:2948-5085
database_cross_reference: LCH_NW:sh89004729
database_cross_reference: LNC:LP19612-8
database_cross_reference: LNC:MTHU008685
database_cross_reference: MSH:D004876
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:000680
database_cross_reference: NDFRT:N0000007620
database_cross_reference: RCD:Xa3do
database_cross_reference: RCD:x01R7
database_cross_reference: RXNORM:4023
database_cross_reference: SNMI:C-30850
database_cross_reference: SNOMEDCT_US:32824001
database_cross_reference: SNOMEDCT_US:350623006
database_cross_reference: USPMG:MTHU000421

Lobeline
type: Class
subclass of: Alkaloids
subclass of: Piperidines
MCID: MC00007658
PMOID: PMO:00018122
Subclass_of: Alkaloids
Subclass_of: Piperidines
Synonym: (-)-Lobeline
Synonym: 2-(6-(Beta-Hydroxyphenethyl)-1-Methyl-2-Piperidyl)acetophenone
Synonym: Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, (2R-(2alpha,6alpha(S*)))-
Synonym: Inflatine
Synonym: LOBELINE
Synonym: Lobeline (substance)
Synonym: Lobeline - chemical
Synonym: Lobeline - chemical (substance)
Synonym: Lobeline [Chemical/Ingredient]
Synonym: lobeline
Tree Number: T6.3.3.11
Tree Number: T6.3.5.16.14
database_cross_reference: DRUGBANK:DB05137
database_cross_reference: MSH:D008120
database_cross_reference: NCI:C93261
database_cross_reference: NCI_FDA:D0P25S3P81
database_cross_reference: NCI_NCI-GLOSS:CDR0000476287
database_cross_reference: NDDF:001771
database_cross_reference: NDFRT:N0000167203
database_cross_reference: RXNORM:6464
database_cross_reference: SNM:E-7728
database_cross_reference: SNMI:C-30387
database_cross_reference: SNOMEDCT_US:362945003
database_cross_reference: SNOMEDCT_US:91403002

Pilocarpine
type: Class
subclass of: Alkaloids
MCID: MC00010217
PMOID: PMO:00018123
Subclass_of: Alkaloids
Synonym: (3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone
Synonym: (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone
Synonym: 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-
Synonym: Diocarpine
Synonym: E-pilo 1 Ophthalmic Solution
Synonym: E-pilo 2 Ophthalmic Solution
Synonym: E-pilo 4 Ophthalmic Solution
Synonym: E-pilo 6 Ophthalmic Solution
Synonym: E-pilo-1 Oph Soln
Synonym: E-pilo-2 Oph Soln
Tree Number: T6.3.3.14
database_cross_reference: AOD:0000020518
database_cross_reference: ATC:N07AX01
database_cross_reference: ATC:S01EB01
database_cross_reference: CHV:0000009735
database_cross_reference: CSP:0092-9479
database_cross_reference: DRUGBANK:DB01085
database_cross_reference: LCH:U003679
database_cross_reference: LCH_NW:sh85102153
database_cross_reference: MEDCIN:41892
database_cross_reference: MMSL:20709
database_cross_reference: MMSL:73122
database_cross_reference: MMSL:d04031
database_cross_reference: MSH:D010862
database_cross_reference: MTHSPL:01MI4Q9DI3
database_cross_reference: NCI:C62068
database_cross_reference: NCI_FDA:01MI4Q9DI3
database_cross_reference: NCI_NCI-GLOSS:CDR0000045573
database_cross_reference: NDDF:001693
database_cross_reference: NDFRT:N0000006106
database_cross_reference: NDFRT:N0000146543
database_cross_reference: PDQ:CDR0000042876
database_cross_reference: PSY:38840
database_cross_reference: RCD:k8d..
database_cross_reference: RXNORM:8328
database_cross_reference: SNM:E-7533
database_cross_reference: SNMI:C-97770
database_cross_reference: SNOMEDCT_US:116539001
database_cross_reference: SNOMEDCT_US:372895002
database_cross_reference: SNOMEDCT_US:90356005
database_cross_reference: USPMG:MTHU001101
database_cross_reference: VANDF:4018209

Solanaceous Alkaloids
type: Class
subclass of: Alkaloids
PMOID: PMO:00018124
Subclass_of: Alkaloids
Tree Number: T6.3.3.18

Belladonna Alkaloids
type: Class
subclass of: Tropanes
subclass of: Solanaceous Alkaloids
PMOID: PMO:00018125
Subclass_of: Solanaceous Alkaloids
Subclass_of: Tropanes
Tree Number: T6.3.3.18.1
Tree Number: T6.3.3.20.1

Nicotine
type: Class
subclass of: Solanaceous Alkaloids
subclass of: Pyridines
MCID: MC00008885
PMOID: PMO:00018126
Subclass_of: Pyridines
Subclass_of: Solanaceous Alkaloids
Synonym: (-)-Nicotine
Synonym: (-)-nicotine
Synonym: (S)-(-)-nicotine
Synonym: (S)-(−)-nicotine
Synonym: (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
Synonym: (S)-3-(1-methylpyrrolidin-2-yl)pyridine
Synonym: (S)-3-(N-methylpyrrolidin-2-yl)pyridine
Synonym: (S)-Nicotine
Synonym: (−)-nicotine
Synonym: 1-Methyl-2-(3-pyridyl)pyrrolidine
Tree Number: T6.3.3.18.3
Tree Number: T6.3.5.20.15
database_cross_reference: AOD:0000000678
database_cross_reference: AOD:0000000701
database_cross_reference: AOD:0000021321
database_cross_reference: ATC:N07BA01
database_cross_reference: CHV:0000008707
database_cross_reference: CSP:2511-0531
database_cross_reference: DRUGBANK:DB00184
database_cross_reference: LCH:U003230
database_cross_reference: LCH_NW:sh85091817
database_cross_reference: LNC:LP16219-5
database_cross_reference: LNC:MTHU003222
database_cross_reference: MEDCIN:78269
database_cross_reference: MEDLINEPLUS:108
database_cross_reference: MMSL:11529
database_cross_reference: MMSL:5173
database_cross_reference: MMSL:d00316
database_cross_reference: MSH:D009538
database_cross_reference: MTH:U002107
database_cross_reference: MTHSPL:6M3C89ZY6R
database_cross_reference: NCI:C691
database_cross_reference: NCI_DCP:00839
database_cross_reference: NCI_DTP:NSC0005065
database_cross_reference: NCI_FDA:6M3C89ZY6R
database_cross_reference: NCI_NCI-GLOSS:CDR0000439405
database_cross_reference: NDDF:001770
database_cross_reference: NDFRT:N0000006496
database_cross_reference: NDFRT:N0000148163
database_cross_reference: PDQ:CDR0000042243
database_cross_reference: PSY:34010
database_cross_reference: RCD:XaCvW
database_cross_reference: RCD:du3..
database_cross_reference: RXNORM:7407
database_cross_reference: SNM:E-6906
database_cross_reference: SNMI:C-30384
database_cross_reference: SNOMEDCT_US:323283001
database_cross_reference: SNOMEDCT_US:373462006
database_cross_reference: SNOMEDCT_US:68540007
database_cross_reference: USPMG:MTHU002074
database_cross_reference: VANDF:4020286

Solanine
type: Class
subclass of: Solanaceous Alkaloids
subclass of: Sterols
subclass of: PMO:00020988
MCID: MC00012037
PMOID: PMO:00018127
Subclass_of: Saponins
Subclass_of: Solanaceous Alkaloids
Subclass_of: Sterols
Synonym: SOLANINE
Synonym: Solanine (substance)
Synonym: Solanine [Chemical/Ingredient]
Synonym: Solatunine
Synonym: beta-D-Galactopyranoside, (3beta)-solanid-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(beta-D-glucopyranosyl-(1-3))-
Synonym: solanine
Tree Number: T6.3.3.18.4
Tree Number: T6.8.6.15.3
Tree Number: T6.9.11.5.8
database_cross_reference: CHV:0000011514
database_cross_reference: LCH:U004380
database_cross_reference: LCH_NW:sh86007719
database_cross_reference: MSH:D012992
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:3FYV8328OK
database_cross_reference: NDFRT:N0000168476
database_cross_reference: RCD:Xa3dr
database_cross_reference: RXNORM:1745416
database_cross_reference: SNM:E-6875
database_cross_reference: SNMI:C-30402
database_cross_reference: SNOMEDCT_US:15735000

Tomatine
type: Class
subclass of: Solanaceous Alkaloids
subclass of: PMO:00020950
MCID: MC00012907
PMOID: PMO:00018128
Subclass_of: Glycosides
Subclass_of: Solanaceous Alkaloids
Synonym: Tomatine [Chemical/Ingredient]
Synonym: beta-D-Galactopyranoside, (3beta,5alpha,22beta,25S)-spirosolan-3-yl O-beta-D-glucopyranosyl-(1-2)-O-(beta-D-xylopyranosyl-(1-3))-O-beta-D-glucopyranosyl-(1-4)-
Tree Number: T6.3.3.18.5
Tree Number: T6.8.6.18
database_cross_reference: MSH:D014053
database_cross_reference: NDFRT:N0000168457

Veratrum Alkaloids
type: Class
subclass of: Alkaloids
PMOID: PMO:00018129
Subclass_of: Alkaloids
Tree Number: T6.3.3.21

Swainsonine
type: Class
subclass of: Alkaloids
MCID: MC00043314
PMOID: PMO:00018130
Subclass_of: Alkaloids
Synonym: 1,2,8-Indolizinetriol, octahydro-, (1S-(1alpha,2alpha,8beta,8abeta))-
Synonym: Swainsonine [Chemical/Ingredient]
Tree Number: T6.3.3.23
database_cross_reference: LCH_NW:sh89003351
database_cross_reference: MSH:D017026
database_cross_reference: NDFRT:N0000166901

Amaryllidaceae Alkaloids
type: Class
subclass of: Alkaloids
PMOID: PMO:00018131
Subclass_of: Alkaloids
Tree Number: T6.3.3.27

Opiate Alkaloids
type: Class
subclass of: Alkaloids
MCID: MC00070944
PMOID: PMO:00018132
Subclass_of: Alkaloids
Synonym: Alkaloid Opiates
Synonym: Alkaloids, Opiate
Synonym: Opiate Alkaloids [Chemical/Ingredient]
Synonym: Opiates
Synonym: Opiates, Alkaloid
Synonym: Opium Alkaloids
Synonym: Opium alkaloid
Synonym: Opium alkaloid (product)
Synonym: Opium alkaloid (substance)
Synonym: alkaloids opiate
Tree Number: T6.3.3.30
database_cross_reference: AOD:0000028959
database_cross_reference: CHV:0000021492
database_cross_reference: CHV:0000031709
database_cross_reference: CSP:0092-9113
database_cross_reference: MSH:D053610
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000175103
database_cross_reference: PSY:35500
database_cross_reference: RCD:x01Kl
database_cross_reference: SNOMEDCT_US:350304007
database_cross_reference: SNOMEDCT_US:395994000

Heterocyclic Compounds, Bridged-Ring
type: Class
subclass of: Heterocyclic Compounds
MCID: MC00006229
PMOID: PMO:00018136
Subclass_of: Heterocyclic Compounds
Synonym: BRIDGED RING HETEROCYCLIC CPDS
Synonym: Bridged Ring Heterocyclic Compounds
Synonym: Bridged-Ring Heterocyclic Compounds
Synonym: Compounds, Bridged-Ring Heterocyclic
Synonym: HETEROCYCLIC CPDS BRIDGED RING
Synonym: Heterocyclic Compounds, Bridged Ring
Synonym: Heterocyclic Compounds, Bridged-Ring [Chemical/Ingredient]
Synonym: bridged-ring heterocyclic compounds
Tree Number: T6.3.4
database_cross_reference: AOD:0000020969
database_cross_reference: MSH:D006572
database_cross_reference: NDFRT:N0000008258

Cyclazocine
type: Class
subclass of: Heterocyclic Compounds, Bridged-Ring
subclass of: Azocines
MCID: MC00003396
PMOID: PMO:00018137
Subclass_of: Azocines
Subclass_of: Heterocyclic Compounds, Bridged-Ring
Synonym: 2,6-Methano-3-benzazocin-8-ol, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-
Synonym: CYCLAZOCINE
Synonym: Cyclazocine [Chemical/Ingredient]
Synonym: cyclazocine
Tree Number: T6.3.4.1
Tree Number: T6.3.5.5.1
database_cross_reference: AOD:0000020721
database_cross_reference: CSP:0389-9118
database_cross_reference: MSH:D003496
database_cross_reference: NCI:C80571
database_cross_reference: NCI_FDA:J5W1B1159C
database_cross_reference: NDFRT:N0000167218

Ethylketocyclazocine
type: Class
subclass of: Cyclazocine
MCID: MC00041067
PMOID: PMO:00018138
Subclass_of: Cyclazocine
Synonym: 2,6-Methano-3-benzazocin-1(2H)-one, 3-(cyclopropylmethyl)-6-ethyl-3,4,5,6-tetrahydro-8-hydroxy-11-methyl-, (2alpha,6alpha,11S*)-(+-)-
Synonym: Ethylketazocine
Synonym: Ethylketocyclazocine [Chemical/Ingredient]
Tree Number: T6.3.4.1.1
database_cross_reference: MSH:D016314
database_cross_reference: NDFRT:N0000167219

Quinuclidines
type: Class
subclass of: Heterocyclic Compounds, Bridged-Ring
MCID: MC00011081
PMOID: PMO:00018139
Subclass_of: Heterocyclic Compounds, Bridged-Ring
Synonym: Quinuclidine
Synonym: Quinuclidine (substance)
Synonym: Quinuclidines [Chemical/Ingredient]
Synonym: quinuclidine
Tree Number: T6.3.4.3
database_cross_reference: AOD:0000020972
database_cross_reference: CSP:2532-6706
database_cross_reference: MSH:D011812
database_cross_reference: NDFRT:N0000007740
database_cross_reference: SNOMEDCT_US:415225006

Bridged Bicyclo Compounds, Heterocyclic
type: Class
subclass of: Heterocyclic Compounds, Bridged-Ring
MCID: MC00099032
PMOID: PMO:00018140
Subclass_of: Heterocyclic Compounds, Bridged-Ring
Synonym: BICYCLO CPDS HETEROCYCLIC
Synonym: Bicyclic Heterocyclic Compounds
Synonym: Bicyclic Heterocyclic Cpds
Synonym: Bicyclo Compounds, Heterocyclic
Synonym: Bridged Bicyclo Compounds, Heterocyclic [Chemical/Ingredient]
Synonym: HETEROCYCLIC BICYCLO CPDS
Synonym: HETEROCYCLIC COMPOUNDS BICYCLIC
Synonym: HETEROCYCLIC CPDS BICYCLIC
Synonym: Heterocyclic Bicyclo Compounds
Synonym: Heterocyclic Compounds, Bicyclic
Tree Number: T6.3.4.5
database_cross_reference: MSH:D019086
database_cross_reference: NDFRT:N0000007813

Heterocyclic Compounds, 1-Ring
type: Class
subclass of: Heterocyclic Compounds
MCID: MC00006225
PMOID: PMO:00018141
Subclass_of: Heterocyclic Compounds
Synonym: 1-Ring Heterocyclic Compounds
Synonym: 1-Ring Heterocyclic Cpds
Synonym: 1-ring heterocyclic compounds
Synonym: HETEROCYCLIC COMPOUNDS A 1 RING
Synonym: HETEROCYCLIC CPDS 1 RING
Synonym: Heterocyclic Compounds, 1 Ring
Synonym: Heterocyclic Compounds, 1-Ring [Chemical/Ingredient]
Synonym: Heterocyclic Cpds, 1 Ring
Synonym: Heterocyclic Cpds, 1-Ring
Tree Number: T6.3.5
database_cross_reference: AOD:0000020715
database_cross_reference: MSH:D006573
database_cross_reference: NDFRT:N0000008259

Neonicotinoids
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
PMOID: PMO:00018142
Subclass_of: Heterocyclic Compounds, 1-Ring
Tree Number: T6.3.5.1

Azepines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00001435
PMOID: PMO:00018143
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Azepines [Chemical/Ingredient]
Synonym: Hexamethyleneimines
Synonym: azepine
Tree Number: T6.3.5.2
database_cross_reference: AOD:0000020718
database_cross_reference: CSP:0314-3297
database_cross_reference: LCH:U000458
database_cross_reference: MSH:D001381
database_cross_reference: NDFRT:N0000007872

Dilazep
type: Class
subclass of: Azepines
MCID: MC00003947
PMOID: PMO:00018144
Subclass_of: Azepines
Synonym: Benzoic acid, 3,4,5-trimethoxy-, (tetrahydro-1H-1,4-diazepine-1,4(5H)-diyl)di-3,1-propanediyl ester
Synonym: Biopropazepan Trimethoxybenzoate
Synonym: DILAZEP
Synonym: Dilazep [Chemical/Ingredient]
Synonym: Trimethoxybenzoate, Biopropazepan
Synonym: dilazep
Tree Number: T6.3.5.2.2
database_cross_reference: ATC:C01DX10
database_cross_reference: MSH:D004109
database_cross_reference: NCI:C65389
database_cross_reference: NCI_FDA:F8KLC2BD5Z
database_cross_reference: NDFRT:N0000167247

Meptazinol
type: Class
subclass of: Azepines
MCID: MC00008083
PMOID: PMO:00018145
Subclass_of: Azepines
Synonym: M-(3-Ethylhexahydro-1-Methyl-1H-Azepin-3-Yl)Phenol
Synonym: MEPTAZINOL
Synonym: Meptazinol (product)
Synonym: Meptazinol (substance)
Synonym: Meptazinol [Chemical/Ingredient]
Synonym: Meptazinol [anaesthesia]
Synonym: Meptazinol [analgesic]
Synonym: Meptazinol [analgesic] (product)
Synonym: Meptazinol [analgesic] (substance)
Synonym: Meptazinol [anesthesia]
Tree Number: T6.3.5.2.3
database_cross_reference: ATC:N02AX05
database_cross_reference: CHV:0000007973
database_cross_reference: MSH:D008621
database_cross_reference: NCI:C87360
database_cross_reference: NCI_FDA:18Y7S5JKZD
database_cross_reference: NDDF:004001
database_cross_reference: NDFRT:N0000167248
database_cross_reference: RCD:djb..
database_cross_reference: RCD:o44..
database_cross_reference: RCD:x02Mf
database_cross_reference: RCDAE:o44..
database_cross_reference: RXNORM:6761
database_cross_reference: SNOMEDCT_US:322562001
database_cross_reference: SNOMEDCT_US:333933005
database_cross_reference: SNOMEDCT_US:354055003
database_cross_reference: SNOMEDCT_US:395783008

Oxazepines
type: Class
subclass of: Azepines
MCID: MC00009556
PMOID: PMO:00018146
Subclass_of: Azepines
Synonym: Oxazepines [Chemical/Ingredient]
Tree Number: T6.3.5.2.4
database_cross_reference: MSH:D010077
database_cross_reference: NDFRT:N0000167249

Pentylenetetrazole
type: Class
subclass of: Azepines
MCID: MC00009850
PMOID: PMO:00018147
Subclass_of: Azepines
Synonym: 5H-Tetrazolo(1,5-a)azepine, 6,7,8,9-tetrahydro-
Synonym: Leptazole
Synonym: PENTETRAZOL
Synonym: PENTYLENETETRAZOL
Synonym: PTZ
Synonym: Pentamethylenetetrazole
Synonym: Pentetrazol
Synonym: Pentetrazole
Synonym: Pentylenetetrazol
Synonym: Pentylenetetrazol (substance)
Tree Number: T6.3.5.2.5
database_cross_reference: AOD:0000020719
database_cross_reference: ATC:R07AB03
database_cross_reference: CHV:0000009449
database_cross_reference: CSP:2074-6888
database_cross_reference: LNC:LP16240-1
database_cross_reference: LNC:MTHU017327
database_cross_reference: MEDCIN:41168
database_cross_reference: MSH:D010433
database_cross_reference: NCI:C81054
database_cross_reference: NCI_FDA:WM5Z385K7T
database_cross_reference: NDDF:001379
database_cross_reference: NDFRT:N0000005753
database_cross_reference: NDFRT:N0000147404
database_cross_reference: PSY:37270
database_cross_reference: PSY:37280
database_cross_reference: RCD:Xa0HX
database_cross_reference: RXNORM:8015
database_cross_reference: SNM:E-7733
database_cross_reference: SNMI:C-655B0
database_cross_reference: SNOMEDCT_US:19901000
database_cross_reference: SNOMEDCT_US:277018008
database_cross_reference: VANDF:4019159

Azetines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00001438
PMOID: PMO:00018148
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Azetines [Chemical/Ingredient]
Tree Number: T6.3.5.3
database_cross_reference: MSH:D001385
database_cross_reference: NDFRT:N0000011459

Azetidines
type: Class
subclass of: Azetines
MCID: MC00001437
PMOID: PMO:00018149
Subclass_of: Azetines
Synonym: Azetidines [Chemical/Ingredient]
Synonym: azetidine
Tree Number: T6.3.5.3.1
database_cross_reference: CSP:2074-5348
database_cross_reference: MSH:D001384
database_cross_reference: MTH:U001723
database_cross_reference: NDFRT:N0000011458

Azirines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00001442
PMOID: PMO:00018151
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Azacyclopropanes, Unsaturated
Synonym: Azirines [Chemical/Ingredient]
Synonym: Unsaturated Azacyclopropanes
Tree Number: T6.3.5.4
database_cross_reference: MSH:D001389
database_cross_reference: NDFRT:N0000008214

Aziridines
type: Class
subclass of: Azirines
MCID: MC00001441
PMOID: PMO:00018152
Subclass_of: Azirines
Synonym: Azacyclopropanes
Synonym: Azacyclopropanes, Saturated
Synonym: Aziridines [Chemical/Ingredient]
Synonym: Dimethyleneimines
Synonym: Ethyleneimines
Synonym: Ethylenimine Compound
Synonym: Saturated Azacyclopropanes
Tree Number: T6.3.5.4.1
database_cross_reference: LCH_NW:sh2007004890
database_cross_reference: MSH:D001388
database_cross_reference: NCI:C292
database_cross_reference: NDFRT:N0000008213

Triethylenemelamine
type: Class
subclass of: Triazines
MCID: MC00013076
PMOID: PMO:00018155
Subclass_of: Triazines
Synonym: 1,3,5-Triazine, 2,4,6-tris(1-aziridinyl)-
Synonym: 2,4,6-Triethylimino-1,3,5-Triazine
Synonym: Melamine, Triethylene
Synonym: TEM
Synonym: TRIETHYLENEMELAMINE
Synonym: Tretamine
Synonym: Triethylene Melamine
Synonym: Triethylenemelamine (substance)
Synonym: Triethylenemelamine [Chemical/Ingredient]
Synonym: triethylenemelamine
Tree Number: T6.3.5.26.8
database_cross_reference: CHV:0000012553
database_cross_reference: CSP:0315-4137
database_cross_reference: MSH:D014265
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C29858
database_cross_reference: NCI_FDA:F7IY6HZG9D
database_cross_reference: NDDF:002636
database_cross_reference: NDFRT:N0000167161
database_cross_reference: SNM:E-8336
database_cross_reference: SNMI:C-78270
database_cross_reference: SNOMEDCT_US:20887007

Azocines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00001445
PMOID: PMO:00018156
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Azocines [Chemical/Ingredient]
Synonym: azocine
Tree Number: T6.3.5.5
database_cross_reference: AOD:0000020720
database_cross_reference: MSH:D001392
database_cross_reference: NDFRT:N0000167215

Oxazocines
type: Class
subclass of: Azocines
MCID: MC00009558
PMOID: PMO:00018157
Subclass_of: Azocines
Synonym: Oxazocines [Chemical/Ingredient]
Tree Number: T6.3.5.5.2
database_cross_reference: MSH:D010079
database_cross_reference: NDFRT:N0000167216

Azoles
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00001446
PMOID: PMO:00018159
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Azole
Synonym: Azole (substance)
Synonym: Azoles [Chemical/Ingredient]
Synonym: azole
Synonym: azoles
Tree Number: T6.3.5.6
database_cross_reference: AOD:0000020722
database_cross_reference: CHV:0000001641
database_cross_reference: CSP:2074-6285
database_cross_reference: LCH_NW:sh2007003939
database_cross_reference: MSH:D001393
database_cross_reference: NDFRT:N0000008217
database_cross_reference: RCD:Xa7kM
database_cross_reference: SNOMEDCT_US:300903003

Imidazoles
type: Class
subclass of: Azoles
MCID: MC00006716
PMOID: PMO:00018160
Subclass_of: Azoles
Synonym: Imidazole
Synonym: Imidazoles [Chemical/Ingredient]
Synonym: imidazole
Synonym: imidazoles
Tree Number: T6.3.5.6.1
database_cross_reference: AOD:0000020737
database_cross_reference: CHV:0000006566
database_cross_reference: CSP:1549-3456
database_cross_reference: DRUGBANK:DB03366
database_cross_reference: LCH_NW:sh85064491
database_cross_reference: MSH:D007093
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007769

Amlodipine Besylate, Olmesartan Medoxomil Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00698812
PMOID: PMO:00018162
Subclass_of: Drug Combinations
Synonym: Amlodipine Besylate Olmesartan Medoxomil
Synonym: Amlodipine Besylate Olmesartan Medoxomil Drug Combination
Synonym: Amlodipine Besylate, Olmesartan Medoxomil
Synonym: Amlodipine Besylate, Olmesartan Medoxomil Drug Combination [Chemical/Ingredient]
Synonym: Amlodipine Besylate-Olmesartan Medoxomil
Synonym: Amlodipine Besylate-Olmesartan Medoxomil Drug Combination
Synonym: Amlodipine besylate and Olmesartan medoxomil
Synonym: Besylate-Olmesartan Medoxomil, Amlodipine
Synonym: Medoxomil, Amlodipine Besylate-Olmesartan
Synonym: amlodipine besylate + olmesartan medoxomil
Tree Number: T6.15.3.4
database_cross_reference: DRUGBANK:DB00275
database_cross_reference: DRUGBANK:DB00381
database_cross_reference: MEDCIN:303857
database_cross_reference: MSH:D000068558
database_cross_reference: NDFRT:N0000191968

Vardenafil Dihydrochloride
type: Class
subclass of: Piperazines
MCID: MC00741383
PMOID: PMO:00018163
Subclass_of: Piperazines
Synonym: Dihydrochloride, Vardenafil
Synonym: VARDENAFIL DIHYDROCHLORIDE
Synonym: Vardenafil Dihydrochloride [Chemical/Ingredient]
Synonym: vardenafil dihydrochloride
Tree Number: T6.3.5.15.5
database_cross_reference: MSH:D000069058
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C76892
database_cross_reference: NCI_FDA:5O8R96XMH7
database_cross_reference: NDFRT:N0000191974

Biotin
type: Class
subclass of: Coenzymes
MCID: MC00001763
PMOID: PMO:00018166
Subclass_of: Coenzymes
Synonym: (+)-Biotin
Synonym: (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid
Synonym: (3AS,4S,6ar)-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valeric acid
Synonym: -(+)-Biotin
Synonym: 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-
Synonym: 5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoic acid
Synonym: 5-(3-oxo-7-thia-2,4-diazabicyclo[3.3.0]oct-8-yl)pentanoic acid
Synonym: Acti-biotin 300 Caplet 300mcg
Synonym: Adult Infuvite Multiple Vitamins
Synonym: Am Caps
Tree Number: T6.7.1.2
database_cross_reference: AOD:0000018225
database_cross_reference: AOD:0000028210
database_cross_reference: ATC:A11HA05
database_cross_reference: CHV:0000001914
database_cross_reference: CSP:3147-0366
database_cross_reference: DRUGBANK:DB00121
database_cross_reference: LCH:U000584
database_cross_reference: LCH_NW:sh85014267
database_cross_reference: LNC:LP15451-5
database_cross_reference: LNC:MTHU008664
database_cross_reference: MEDCIN:191869
database_cross_reference: MEDLINEPLUS:5376
database_cross_reference: MMSL:11819
database_cross_reference: MMSL:118935
database_cross_reference: MMSL:d06867
database_cross_reference: MSH:D001710
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:6SO6U10H04
database_cross_reference: NCI:C309
database_cross_reference: NCI_CRCH:C309
database_cross_reference: NCI_DTP:NSC0063865
database_cross_reference: NCI_FDA:6SO6U10H04
database_cross_reference: NCI_NCI-GLOSS:CDR0000556403
database_cross_reference: NCI_NCI-GLOSS:CDR0000629152
database_cross_reference: NDDF:001035
database_cross_reference: NDFRT:N0000005852
database_cross_reference: NDFRT:N0000146018
database_cross_reference: RCD:X80LX
database_cross_reference: RXNORM:1588
database_cross_reference: SNM:E-8758
database_cross_reference: SNM:F-16280
database_cross_reference: SNMI:C-A4022
database_cross_reference: SNMI:F-BB380
database_cross_reference: SNOMEDCT_US:13813003
database_cross_reference: SNOMEDCT_US:8919000
database_cross_reference: VANDF:4017638

Isoxazoles
type: Class
subclass of: Azoles
MCID: MC00007122
PMOID: PMO:00018193
Subclass_of: Azoles
Synonym: 1-Oxa-2-azacyclopentadiene
Synonym: Isoxazole
Synonym: Isoxazole (substance)
Synonym: Isoxazoles [Chemical/Ingredient]
Synonym: isoxazole
Synonym: isoxazoles
Tree Number: T6.3.5.6.2
database_cross_reference: AOD:0000020749
database_cross_reference: CSP:2163-5959
database_cross_reference: MSH:D007555
database_cross_reference: NDFRT:N0000007968
database_cross_reference: SNOMEDCT_US:429343000

Paliperidone Palmitate
type: Class
subclass of: Pyrimidines
MCID: MC00748689
PMOID: PMO:00018194
Subclass_of: Pyrimidines
Synonym: Hexadecanoic Acid, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido(1,2-a)pyrimidin-9-yl Ester
Synonym: PALIPERIDONE PALMITATE
Synonym: Paliperidone Palmitate [Chemical/Ingredient]
Synonym: Paliperidone palmitate
Synonym: Paliperidone palmitate (substance)
Synonym: Palmitate, Paliperidone
Synonym: antipsychotics paliperidone palmitate
Synonym: paliperidone palmitate
Synonym: paliperidone palmitate (medication)
Tree Number: T6.3.5.21.4
database_cross_reference: MEDCIN:345102
database_cross_reference: MMSL:26654
database_cross_reference: MSH:D000068882
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:R8P8USM8FR
database_cross_reference: NCI:C83917
database_cross_reference: NCI_FDA:R8P8USM8FR
database_cross_reference: NDDF:013207
database_cross_reference: NDFRT:N0000181687
database_cross_reference: NDFRT:N0000191975
database_cross_reference: RXNORM:858045
database_cross_reference: SNOMEDCT_US:706896003
database_cross_reference: VANDF:4029217

Ibotenic Acid
type: Class
subclass of: PMO:00024389
MCID: MC00006657
PMOID: PMO:00018196
Subclass_of: Mycotoxins
Synonym: 5-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-3-oxo-
Synonym: Acid, Ibotenic
Synonym: Ibotenic Acid [Chemical/Ingredient]
Synonym: Ibotenic acid
Synonym: Ibotenic acid (substance)
Tree Number: T6.13.8.6.6
database_cross_reference: MSH:D007051
database_cross_reference: NDFRT:N0000171427
database_cross_reference: PSY:24245
database_cross_reference: RCD:Xa9Sg
database_cross_reference: SNOMEDCT_US:303346008

Oxazoles
type: Class
subclass of: Azoles
MCID: MC00009559
PMOID: PMO:00018199
Subclass_of: Azoles
Synonym: 1,3-Oxazole
Synonym: Oxazoles [Chemical/Ingredient]
Synonym: oxazole
Synonym: oxazoles
Tree Number: T6.3.5.6.3
database_cross_reference: AOD:0000020748
database_cross_reference: CHV:0000009142
database_cross_reference: CSP:2163-5023
database_cross_reference: LCH:U003421
database_cross_reference: LCH_NW:sh85096293
database_cross_reference: MSH:D010080
database_cross_reference: NDFRT:N0000007835

Muscimol
type: Class
subclass of: PMO:00024389
MCID: MC00008483
PMOID: PMO:00018202
Subclass_of: Mycotoxins
Synonym: 3(2H)-Isoxazolone, 5-(aminomethyl)-
Synonym: Agarin
Synonym: Muscimol (substance)
Synonym: Muscimol [Chemical/Ingredient]
Synonym: Pantherine
Synonym: Pantherine (substance)
Synonym: muscimol
Tree Number: T6.13.8.6.7
database_cross_reference: CSP:4000-0256
database_cross_reference: DRUGBANK:DB12458
database_cross_reference: MSH:D009118
database_cross_reference: NDFRT:N0000171410
database_cross_reference: PSY:32525
database_cross_reference: PSY:36267
database_cross_reference: RCD:Xa9Se
database_cross_reference: RCD:Xa9Sf
database_cross_reference: SNOMEDCT_US:303344006
database_cross_reference: SNOMEDCT_US:303345007

Quisqualic Acid
type: Class
subclass of: PMO:00021256
MCID: MC00041228
PMOID: PMO:00018207
Subclass_of: Amino Acids
Synonym: 1,2,4-Oxadiazolidine-2-propanoic acid, alpha-amino-3,5-dioxo-, (S)-
Synonym: Quisqualic Acid [Chemical/Ingredient]
Tree Number: T6.10.1.19
database_cross_reference: MSH:D016318
database_cross_reference: NDFRT:N0000170217

Pyrazoles
type: Class
subclass of: Azoles
MCID: MC00010987
PMOID: PMO:00018212
Subclass_of: Azoles
Synonym: Pyrazole Compound
Synonym: Pyrazoles [Chemical/Ingredient]
Tree Number: T6.3.5.6.4
database_cross_reference: LCH:U003965
database_cross_reference: LCH_NW:sh85109308
database_cross_reference: MSH:D011720
database_cross_reference: NCI:C29396
database_cross_reference: NDFRT:N0000007569

Epirizole
type: Class
subclass of: Pyrimidines
MCID: MC00004615
PMOID: PMO:00018214
Subclass_of: Pyrimidines
Synonym: 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
Synonym: EPIRIZOLE
Synonym: Epirizole [Chemical/Ingredient]
Synonym: Karmarte
Synonym: Mepirizole
Synonym: Methopyrimazole
Synonym: Polihexanid
Synonym: Pyrimidine, 4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methyl-
Synonym: epirizole
Synonym: mepirizole
Tree Number: T6.3.5.21.8
database_cross_reference: CHV:0000004569
database_cross_reference: DRUGBANK:DB08991
database_cross_reference: MSH:D004840
database_cross_reference: NCI:C76075
database_cross_reference: NCI_FDA:3B46O2FH8I
database_cross_reference: NDFRT:N0000167187

Oxypurinol
type: Class
subclass of: Pyrimidines
MCID: MC00009594
PMOID: PMO:00018216
Subclass_of: Pyrimidines
Synonym: 1H-Pyrazolo(3,4-D)Pyrimidine,4,6(5H,7H)-Dione
Synonym: 1H-Pyrazolo(3,4-D)Pyrimidine-4,6-Diol
Synonym: 1H-Pyrazolo(3,4-d)pyrimidine-4,6(5H,7H)-dione
Synonym: 1H-Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
Synonym: 1H-Pyrazolo[3,4-d]pyrimidine-4,6-diol
Synonym: 6-hydroxy allopurinol
Synonym: Alloxanthine
Synonym: DHPP
Synonym: OXYPURINOL
Synonym: Oxipurinol
Tree Number: T6.3.5.21.14
database_cross_reference: CHV:0000009163
database_cross_reference: DRUGBANK:DB05262
database_cross_reference: LNC:LP18483-5
database_cross_reference: LNC:MTHU003101
database_cross_reference: LNC:MTHU036234
database_cross_reference: MSH:D010117
database_cross_reference: NCI:C87294
database_cross_reference: NCI_FDA:G97OZE5068
database_cross_reference: NDDF:008719
database_cross_reference: NDFRT:N0000167175

Pyrroles
type: Class
subclass of: Azoles
MCID: MC00011030
PMOID: PMO:00018227
Subclass_of: Azoles
Synonym: 1-aza-2,4-cyclopentadiene
Synonym: Pyrrole
Synonym: Pyrrole (substance)
Synonym: Pyrroles [Chemical/Ingredient]
Synonym: pyrrole
Synonym: pyrroles
Tree Number: T6.3.5.6.5
database_cross_reference: AOD:0000020827
database_cross_reference: CHV:0000010466
database_cross_reference: CSP:2520-8707
database_cross_reference: LCH:U003976
database_cross_reference: LCH_NW:sh85109365
database_cross_reference: LNC:LP18579-0
database_cross_reference: LNC:MTHU004692
database_cross_reference: MSH:D011758
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007592
database_cross_reference: RCD:X80CP
database_cross_reference: SNOMEDCT_US:115667008

Atorvastatin Calcium
type: Class
subclass of: PMO:00021159
MCID: MC00100050
PMOID: PMO:00018228
Subclass_of: Heptanoic Acids
Synonym: ATORVASTATIN CALCIUM
Synonym: Atorvastatin Calcium Hydrate
Synonym: Atorvastatin Calcium Trihydrate
Synonym: Atorvastatin Calcium [Chemical/Ingredient]
Synonym: Atorvastatin calcium
Synonym: Atorvastatin calcium (substance)
Synonym: Atorvastatin, Calcium Salt
Synonym: Calcium Salt Atorvastatin
Synonym: Calcium, Atorvastatin
Synonym: atorvastatin calcium
Tree Number: T6.9.3.7.1
database_cross_reference: CHV:0000027737
database_cross_reference: DRUGBANK:DB01076
database_cross_reference: MEDCIN:78272
database_cross_reference: MMSL:186242
database_cross_reference: MSH:D000069059
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:48A5M73Z4Q
database_cross_reference: NCI:C28837
database_cross_reference: NCI_DCP:09486
database_cross_reference: NCI_FDA:48A5M73Z4Q
database_cross_reference: NCI_NCI-GLOSS:CDR0000535469
database_cross_reference: NDDF:006322
database_cross_reference: NDFRT:N0000148468
database_cross_reference: NDFRT:N0000191916
database_cross_reference: PDQ:CDR0000460239
database_cross_reference: RXNORM:83366
database_cross_reference: SNOMEDCT_US:108601004
database_cross_reference: USPMG:MTHU001002
database_cross_reference: VANDF:4020999

Prodigiosin
type: Class
subclass of: PMO:00024379
MCID: MC00010658
PMOID: PMO:00018230
Subclass_of: Pigments, Biological
Synonym: 2,2'-Bi-1H-pyrrole, 4-methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)-
Synonym: Prodigiosin (substance)
Synonym: Prodigiosin -RETIRED-
Synonym: Prodigiosin [Chemical/Ingredient]
Tree Number: T6.13.7.14
database_cross_reference: MSH:D011353
database_cross_reference: NDFRT:N0000171217
database_cross_reference: SNMI:C-36018
database_cross_reference: SNOMEDCT_US:123044008
database_cross_reference: SNOMEDCT_US:76645001

Tetrazoles
type: Class
subclass of: Azoles
MCID: MC00012674
PMOID: PMO:00018233
Subclass_of: Azoles
Synonym: Tetrazoles [Chemical/Ingredient]
Tree Number: T6.3.5.6.6
database_cross_reference: LCH_NW:sh2002008941
database_cross_reference: MSH:D013777
database_cross_reference: NDFRT:N0000007957

Amlodipine, Valsartan Drug Combination
type: Class
subclass of: PMO:00024461
MCID: MC00632702
PMOID: PMO:00018235
Subclass_of: Drug Combinations
Synonym: - Valsartan, Amlodipine
Synonym: AMLODIPINE and VALSARTAN
Synonym: AMLODIPINE/VALSARTAN
Synonym: Amlodipine + valsartan
Synonym: Amlodipine + valsartan (product)
Synonym: Amlodipine - Valsartan
Synonym: Amlodipine / valsartan
Synonym: Amlodipine Valsartan
Synonym: Amlodipine Valsartan Drug Combination
Synonym: Amlodipine and Valsartan
Tree Number: T6.15.3.10
database_cross_reference: ATC:C09DB01
database_cross_reference: DRUGBANK:DB00177
database_cross_reference: DRUGBANK:DB00381
database_cross_reference: MMSL:d06662
database_cross_reference: MSH:D000068838
database_cross_reference: NDFRT:N0000176226
database_cross_reference: NDFRT:N0000191966
database_cross_reference: RXNORM:729455
database_cross_reference: SNOMEDCT_US:426478002
database_cross_reference: VANDF:4026499

Triazoles
type: Class
subclass of: Azoles
MCID: MC00013051
PMOID: PMO:00018238
Subclass_of: Azoles
Synonym: Triazole
Synonym: Triazole (substance)
Synonym: Triazoles [Chemical/Ingredient]
Synonym: triazole
Synonym: triazoles
Tree Number: T6.3.5.6.8
database_cross_reference: CHV:0000012522
database_cross_reference: CSP:2981-2541
database_cross_reference: LCH:U004768
database_cross_reference: LCH_NW:sh85137417
database_cross_reference: MSH:D014230
database_cross_reference: NDFRT:N0000007567
database_cross_reference: SNOMEDCT_US:426233002

Sitagliptin Phosphate
type: Class
subclass of: Pyrazines
MCID: MC00571283
PMOID: PMO:00018239
Subclass_of: Pyrazines
Synonym: Monohydrate, Sitagliptin Monophosphate
Synonym: Monohydrate, Sitagliptin Phosphate
Synonym: Monophosphate Monohydrate, Sitagliptin
Synonym: Phosphate Monohydrate, Sitagliptin
Synonym: Phosphate, Sitagliptin
Synonym: SITAGLIPTIN PHOSPHATE
Synonym: Sitagliptin Monophosphate Monohydrate
Synonym: Sitagliptin Phosphate Monohydrate
Synonym: Sitagliptin Phosphate [Chemical/Ingredient]
Synonym: Sitagliptin phosphate
Tree Number: T6.3.5.18.1
database_cross_reference: DRUGBANK:DB01261
database_cross_reference: MEDCIN:303370
database_cross_reference: MSH:D000068900
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:TS63EW8X6F
database_cross_reference: NCI:C73811
database_cross_reference: NCI_FDA:TS63EW8X6F
database_cross_reference: NDDF:011791
database_cross_reference: NDFRT:N0000176070
database_cross_reference: NDFRT:N0000191958
database_cross_reference: RXNORM:621590
database_cross_reference: SNOMEDCT_US:425508009
database_cross_reference: USPMG:MTHU002757
database_cross_reference: VANDF:4025781

Trapidil
type: Class
subclass of: Pyrimidines
MCID: MC00013019
PMOID: PMO:00018242
Subclass_of: Pyrimidines
Synonym: (1,2,4)Triazolo(1,5-a)pyrimidin-7-amine, N,N-diethyl-5-methyl-
Synonym: TRAPIDIL
Synonym: Trapidil [Chemical/Ingredient]
Synonym: Trapymin
Synonym: trapidil
Tree Number: T6.3.5.21.22
database_cross_reference: ATC:C01DX11
database_cross_reference: DRUGBANK:DB09283
database_cross_reference: MSH:D014192
database_cross_reference: NCI:C66615
database_cross_reference: NCI_FDA:EYG5Y6355E
database_cross_reference: NDDF:007041
database_cross_reference: NDFRT:N0000167188
database_cross_reference: RXNORM:10735

Itraconazole
type: Class
subclass of: Piperazines
MCID: MC00029657
PMOID: PMO:00018244
Subclass_of: Piperazines
Synonym: (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one
Synonym: 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-
Synonym: ICZ
Synonym: ITRACONAZOLE
Synonym: Itraconazol
Synonym: Itraconazole (product)
Synonym: Itraconazole (substance)
Synonym: Itraconazole [Chemical/Ingredient]
Synonym: Itraconazolum
Synonym: Itrizole
Tree Number: T6.3.5.15.31
database_cross_reference: ATC:J02AC02
database_cross_reference: CHV:0000014243
database_cross_reference: CSP:4006-0055
database_cross_reference: DRUGBANK:DB01167
database_cross_reference: LNC:LP14995-2
database_cross_reference: LNC:MTHU002298
database_cross_reference: MEDCIN:48612
database_cross_reference: MMSL:4940
database_cross_reference: MMSL:64593
database_cross_reference: MMSL:d00102
database_cross_reference: MSH:D017964
database_cross_reference: MTHSPL:304NUG5GF4
database_cross_reference: NCI:C1138
database_cross_reference: NCI_FDA:304NUG5GF4
database_cross_reference: NCI_NCI-GLOSS:CDR0000045161
database_cross_reference: NDDF:003915
database_cross_reference: NDFRT:N0000006753
database_cross_reference: NDFRT:N0000148264
database_cross_reference: PDQ:CDR0000039106
database_cross_reference: RCD:eh9..
database_cross_reference: RXNORM:28031
database_cross_reference: SNMI:C-52BC0
database_cross_reference: SNOMEDCT_US:387532006
database_cross_reference: SNOMEDCT_US:96038009
database_cross_reference: USPMG:MTHU000390
database_cross_reference: VANDF:4020560

Dioxanes
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00003995
PMOID: PMO:00018246
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Dioxane
Synonym: Dioxanes [Chemical/Ingredient]
Synonym: dioxane
Synonym: dioxanes
Tree Number: T6.3.5.7
database_cross_reference: CHV:0000003977
database_cross_reference: LCH:U001404
database_cross_reference: LCH_NW:sh85038139
database_cross_reference: MSH:D004146
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167047

Dioxoles
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00003998
PMOID: PMO:00018247
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Dioxole
Synonym: Dioxole (substance)
Synonym: Dioxoles [Chemical/Ingredient]
Tree Number: T6.3.5.9
database_cross_reference: MSH:D004149
database_cross_reference: NDFRT:N0000007693
database_cross_reference: SNOMEDCT_US:427737006

Dioxolanes
type: Class
subclass of: Dioxoles
MCID: MC00003997
PMOID: PMO:00018248
Subclass_of: Dioxoles
Synonym: Dioxolanes [Chemical/Ingredient]
Tree Number: T6.3.5.9.1
database_cross_reference: LCH_NW:sh90001419
database_cross_reference: MSH:D004148
database_cross_reference: NDFRT:N0000167115

Furans
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00005353
PMOID: PMO:00018249
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Furans [Chemical/Ingredient]
Synonym: furans
Tree Number: T6.3.5.10
database_cross_reference: CHV:0000005296
database_cross_reference: LCH:U001892
database_cross_reference: LCH_NW:sh85052502
database_cross_reference: MSH:D005663
database_cross_reference: NDFRT:N0000007775

Lasalocid
type: Class
subclass of: Furans
MCID: MC00007385
PMOID: PMO:00018250
Subclass_of: Furans
Synonym: (2R-(2alpha(2S*(3R*,4S*,5S*,7R*)3S*,5S*),5alpha,6beta))-6-(7-(5-Ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)tetrahydro-3-methyl-2-furyl)-4-hydroxy-3,5-dimethyl-6-oxononyl)-3-methylsalicylic Acid
Synonym: Benzoic acid, 6-(7-(5-ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)tetrahydro-3-methyl-2-furanyl)-4-hydroxy-3,5-dimethyl-6-oxononyl)-2-hydroxy-3-methyl-, (2R-(2alpha(2S*(3R*,4S*,5S*,7R*),3S*,5S*),5alpha,6beta))-
Synonym: Ionophore X 537A
Synonym: LASALOCID
Synonym: Lasalocid (substance)
Synonym: Lasalocid A
Synonym: Lasalocid [Chemical/Ingredient]
Tree Number: T6.3.5.10.4
database_cross_reference: MSH:D007832
database_cross_reference: MTHSPL:W7V2ZZ2FWB
database_cross_reference: NCI:C79131
database_cross_reference: NCI_FDA:W7V2ZZ2FWB
database_cross_reference: NDFRT:N0000167128
database_cross_reference: RXNORM:1364397
database_cross_reference: SNOMEDCT_VET:5341000009105

Monensin
type: Class
subclass of: Furans
MCID: MC00008381
PMOID: PMO:00018251
Subclass_of: Furans
Synonym: 4-{2-[2-Ethyl-3'-methyl-5'-(tetrahydro-6-hydroxy-6-hydroxymethyl-3,5-dimethylpyran-2-yl)perhydro-2,2'-bifuran-5-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl}3-methoxy-2-methylpentanoic acid
Synonym: MONENSIN
Synonym: Monensin (substance)
Synonym: Monensin [Chemical/Ingredient]
Synonym: monensin
Tree Number: T6.3.5.10.6
database_cross_reference: CSP:0201-7500
database_cross_reference: LNC:LP19629-2
database_cross_reference: LNC:MTHU008688
database_cross_reference: MSH:D008985
database_cross_reference: MTHSPL:906O0YJ6ZP
database_cross_reference: NCI:C83971
database_cross_reference: NCI_FDA:906O0YJ6ZP
database_cross_reference: NDFRT:N0000167131
database_cross_reference: RXNORM:1368208
database_cross_reference: SNMI:C-56D42
database_cross_reference: SNOMEDCT_US:96160009

Nafronyl
type: Class
subclass of: Furans
MCID: MC00008636
PMOID: PMO:00018252
Subclass_of: Furans
Synonym: 2-(Diethylamino)Ethyl Tetrahydro-Alpha-(1-Naphthylmethyl)-2-Furanpropionate
Synonym: 2-Furanpropanoic Acid, Tetrahydro-A-(1-Naphthalenylmethyl)-, 2-(Diethylamino)Ethyl Ester
Synonym: 2-Furanpropanoic acid, tetrahydro-alpha-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester
Synonym: NAFRONYL
Synonym: Nafronyl (substance)
Synonym: Nafronyl [Chemical/Ingredient]
Synonym: Naftidrofuryl
Synonym: Naftidrofuryl (product)
Synonym: Naftidrofuryl (substance)
Synonym: nafronyl
Tree Number: T6.3.5.10.7
database_cross_reference: ATC:C04AX21
database_cross_reference: CHV:0000008463
database_cross_reference: MSH:D009257
database_cross_reference: NCI:C87212
database_cross_reference: NCI_FDA:42H8PQ0NMJ
database_cross_reference: NDDF:003746
database_cross_reference: NDDF:006857
database_cross_reference: NDFRT:N0000167130
database_cross_reference: RCD:x01RH
database_cross_reference: RXNORM:7236
database_cross_reference: SNOMEDCT_US:350627007
database_cross_reference: SNOMEDCT_US:395992001

Nigericin
type: Class
subclass of: Furans
subclass of: Pyrans
MCID: MC00008899
PMOID: PMO:00018253
Subclass_of: Furans
Subclass_of: Pyrans
Synonym: Nigericin [Chemical/Ingredient]
Synonym: nigericin
Tree Number: T6.3.5.10.8
Tree Number: T6.3.5.17.4
database_cross_reference: CHV:0000008718
database_cross_reference: MSH:D009550
database_cross_reference: NDFRT:N0000167174

Ranitidine
type: Class
subclass of: Furans
MCID: MC00011117
PMOID: PMO:00018254
Subclass_of: Furans
Synonym: 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-
Synonym: 7 Select Acid Reducer
Synonym: Acid Reducer
Synonym: Acid Reducer 150
Synonym: Acid Reducer Maximum Strength
Synonym: Acid Reducer Maximum Strength Non-prescription
Synonym: Acid Reducer Regular Strength
Synonym: Act Ranitidine
Synonym: Alquen
Synonym: Apo-ranitidine
Tree Number: T6.3.5.10.10
database_cross_reference: AOD:0000020736
database_cross_reference: ATC:A02BA02
database_cross_reference: CCPSS:1017175
database_cross_reference: CHV:0000010569
database_cross_reference: CSP:4000-0309
database_cross_reference: DRUGBANK:DB00863
database_cross_reference: LCH:U004045
database_cross_reference: LCH_NW:sh85111377
database_cross_reference: LNC:LP17253-3
database_cross_reference: LNC:MTHU005040
database_cross_reference: MEDCIN:40866
database_cross_reference: MMSL:d00021
database_cross_reference: MSH:D011899
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:884KT10YB7
database_cross_reference: NCI:C29412
database_cross_reference: NCI_FDA:884KT10YB7
database_cross_reference: NDDF:004444
database_cross_reference: NDFRT:N0000007158
database_cross_reference: NDFRT:N0000148012
database_cross_reference: RCD:x019Q
database_cross_reference: RXNORM:9143
database_cross_reference: SNMI:C-84060
database_cross_reference: SNOMEDCT_US:372755005
database_cross_reference: SNOMEDCT_US:48174005
database_cross_reference: USPMG:MTHU001193
database_cross_reference: VANDF:4019927

Oxathiins
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00009554
PMOID: PMO:00018255
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Oxathiins [Chemical/Ingredient]
Synonym: Oxathins
Tree Number: T6.3.5.12
database_cross_reference: MSH:D010075
database_cross_reference: NDFRT:N0000167116

Oxazines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00009557
PMOID: PMO:00018256
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Oxazines [Chemical/Ingredient]
Synonym: oxazine
Tree Number: T6.3.5.13
database_cross_reference: CSP:2163-3150
database_cross_reference: MSH:D010078
database_cross_reference: NDFRT:N0000007830

Morpholines
type: Class
subclass of: Oxazines
MCID: MC00008418
PMOID: PMO:00018257
Subclass_of: Oxazines
Synonym: Morpholine
Synonym: Morpholines [Chemical/Ingredient]
Synonym: TETRAHYDROOXAZINES 01 04
Synonym: Tetrahydro 1,4 Oxazines
Synonym: Tetrahydro-1,4-Oxazines
Synonym: morpholine
Tree Number: T6.3.5.13.3
database_cross_reference: CHV:0000008257
database_cross_reference: CSP:2163-3243
database_cross_reference: LCH_NW:sh2008020245
database_cross_reference: MSH:D009025
database_cross_reference: MTH:U002086
database_cross_reference: NDFRT:N0000008073

Piperazines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00010234
PMOID: PMO:00018262
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Piperazines [Chemical/Ingredient]
Tree Number: T6.3.5.15
database_cross_reference: MSH:D010879
database_cross_reference: NDFRT:N0000007927
database_cross_reference: PSY:38885

Eszopiclone
type: Class
subclass of: Piperazines
subclass of: Pyrazines
subclass of: Pyridines
MCID: MC00510730
PMOID: PMO:00018263
Subclass_of: Piperazines
Subclass_of: Pyrazines
Subclass_of: Pyridines
Synonym: (+)-(5S)-6(chloropyridine-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)-pyrazin-5-yl-4-methyl-piperazine-1-carboxylate
Synonym: (+)-(5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate
Synonym: (+)-(5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl-4-methylpiperazine-1-carboxylate
Synonym: (+)-Zopiclone
Synonym: (S)-6-(5-Chloro-2-pyridinyl)- 7-oxo- 6,7-dihydro- 5H-pyrrolo[3,4-b]pyrazin-5-yl- 4-methyl- 1-piperazinecarboxylate
Synonym: (S)-Zopiclone
Synonym: 1-Piperazinecarobxylic acid,4-methyl-,(5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester
Synonym: Dorplen
Synonym: ESZOPICLONE
Synonym: Esleep
Tree Number: T6.3.5.15.8
Tree Number: T6.3.5.18.3
Tree Number: T6.3.5.20.2
database_cross_reference: ATC:N05CF04
database_cross_reference: DRUGBANK:DB00402
database_cross_reference: MEDCIN:301144
database_cross_reference: MMSL:19107
database_cross_reference: MMSL:216714
database_cross_reference: MMSL:d05421
database_cross_reference: MSH:D000069582
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:UZX80K71OE
database_cross_reference: NCI:C65545
database_cross_reference: NCI_FDA:UZX80K71OE
database_cross_reference: NDDF:008781
database_cross_reference: NDFRT:N0000023088
database_cross_reference: NDFRT:N0000175354
database_cross_reference: RXNORM:461016
database_cross_reference: SNOMEDCT_US:409420000
database_cross_reference: SNOMEDCT_US:409421001
database_cross_reference: USPMG:MTHU001691
database_cross_reference: VANDF:4024906

Cinnarizine
type: Class
subclass of: Piperazines
MCID: MC00002911
PMOID: PMO:00018264
Subclass_of: Piperazines
Synonym: 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine
Synonym: 1-Benzhydryl-4-cinnamylpiperazin
Synonym: 1-Cinnamyl-4-(diphenylmethyl)piperazine
Synonym: CINNARIZINE
Synonym: Cinarizina
Synonym: Cinarizine
Synonym: Cinazyn
Synonym: Cinnarizin
Synonym: Cinnarizine (product)
Synonym: Cinnarizine (substance)
Tree Number: T6.3.5.15.10
database_cross_reference: ATC:N07CA02
database_cross_reference: CHV:0000002999
database_cross_reference: DRUGBANK:DB00568
database_cross_reference: LCH:U001030
database_cross_reference: LCH_NW:sh85026036
database_cross_reference: MEDCIN:198539
database_cross_reference: MSH:D002936
database_cross_reference: NCI:C76060
database_cross_reference: NCI_FDA:3DI2E1X18L
database_cross_reference: NDDF:003951
database_cross_reference: NDFRT:N0000167127
database_cross_reference: RCD:bn2..
database_cross_reference: RCD:dh3..
database_cross_reference: RCD:x01Dv
database_cross_reference: RXNORM:2549
database_cross_reference: SNOMEDCT_US:319415005
database_cross_reference: SNOMEDCT_US:322058004
database_cross_reference: SNOMEDCT_US:349958007
database_cross_reference: SNOMEDCT_US:395955001

Cyclizine
type: Class
subclass of: Piperazines
MCID: MC00003403
PMOID: PMO:00018265
Subclass_of: Piperazines
Synonym: (+-)-1-Diphenylmethyl-4-methylpiperazine
Synonym: (N-Benzhydryl)(n'-methyl)diethylenediamine
Synonym: (Â±)-1-diphenylmethyl-4-methylpiperazine
Synonym: 1-(Diphenylmethyl)-4-methylpiperazine
Synonym: 1-Benzhydryl-4-methylpiperazin
Synonym: CYCLIZINE
Synonym: Ciclizina
Synonym: Cyclizine (product)
Synonym: Cyclizine (substance)
Synonym: Cyclizine [Chemical/Ingredient]
Tree Number: T6.3.5.15.11
database_cross_reference: ATC:R06AE03
database_cross_reference: CHV:0000003521
database_cross_reference: DRUGBANK:DB01176
database_cross_reference: LNC:LP16097-5
database_cross_reference: LNC:MTHU016390
database_cross_reference: MMSL:d00858
database_cross_reference: MSH:D003501
database_cross_reference: NCI:C65356
database_cross_reference: NCI_FDA:QRW9FCR9P2
database_cross_reference: NDDF:003395
database_cross_reference: NDFRT:N0000005884
database_cross_reference: NDFRT:N0000147790
database_cross_reference: RCD:dh4..
database_cross_reference: RXNORM:2977
database_cross_reference: SNM:E-8241
database_cross_reference: SNMI:C-51840
database_cross_reference: SNOMEDCT_US:387491004
database_cross_reference: SNOMEDCT_US:85354008
database_cross_reference: VANDF:4019698

Dimethylphenylpiperazinium Iodide
type: Class
subclass of: Piperazines
MCID: MC00004096
PMOID: PMO:00018266
Subclass_of: Piperazines
Synonym: 1,1 Dimethyl 4 phenylpiperazine Iodide
Synonym: 1,1-Dimethyl-4-phenylpiperazine Iodide
Synonym: DMPP
Synonym: Dimethylphenylpiperazinium
Synonym: Dimethylphenylpiperazinium Iodide [Chemical/Ingredient]
Synonym: Iodide, 1,1-Dimethyl-4-phenylpiperazine
Synonym: Iodide, Dimethylphenylpiperazinium
Synonym: Piperazinium, 1,1-dimethyl-4-phenyl-, iodide
Tree Number: T6.3.5.15.13
database_cross_reference: MSH:D004246
database_cross_reference: NDFRT:N0000167126

Flunarizine
type: Class
subclass of: Piperazines
MCID: MC00005179
PMOID: PMO:00018267
Subclass_of: Piperazines
Synonym: FLUNARIZINE
Synonym: Flugeral
Synonym: Flunarizin
Synonym: Flunarizina
Synonym: Flunarizine (substance)
Synonym: Flunarizine [Chemical/Ingredient]
Synonym: Flunarizinum
Synonym: Fluxarten
Synonym: Gradient
Synonym: Novo-flunarizine - Cap 5mg
Tree Number: T6.3.5.15.14
database_cross_reference: ATC:N07CA03
database_cross_reference: CHV:0000005110
database_cross_reference: CSP:0570-4361
database_cross_reference: CSP:2059-0377
database_cross_reference: CSP:2332-0723
database_cross_reference: DRUGBANK:DB04841
database_cross_reference: MSH:D005444
database_cross_reference: NCI:C83718
database_cross_reference: NCI_FDA:R7PLA2DM0J
database_cross_reference: NDDF:003847
database_cross_reference: NDFRT:N0000167125
database_cross_reference: RXNORM:4459
database_cross_reference: SNOMEDCT_US:418221001

Hydroxyzine
type: Class
subclass of: Piperazines
MCID: MC00006520
PMOID: PMO:00018268
Subclass_of: Piperazines
Synonym: 2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol
Synonym: Apo Hydroxyzine Cap 10mg
Synonym: Apo Hydroxyzine Cap 25mg
Synonym: Apo Hydroxyzine Cap 50mg
Synonym: Atarax Cap 10mg
Synonym: Atarax Cap 25mg
Synonym: Atarax Cap 50mg
Synonym: Atarax Im Sol 50mg/ml
Synonym: Atarax Syrup 2mg/ml
Synonym: Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
Tree Number: T6.3.5.15.17
database_cross_reference: ATC:N05BB01
database_cross_reference: CCPSS:1008022
database_cross_reference: CHV:0000006392
database_cross_reference: DRUGBANK:DB00557
database_cross_reference: LNC:LP15171-9
database_cross_reference: LNC:MTHU002560
database_cross_reference: MMSL:4857
database_cross_reference: MMSL:d00907
database_cross_reference: MSH:D006919
database_cross_reference: MTHSPL:30S50YM8OG
database_cross_reference: NCI:C29103
database_cross_reference: NCI_FDA:30S50YM8OG
database_cross_reference: NDDF:001451
database_cross_reference: NDFRT:N0000007299
database_cross_reference: NDFRT:N0000147873
database_cross_reference: PSY:23690
database_cross_reference: RCD:x01E3
database_cross_reference: RXNORM:5553
database_cross_reference: SNM:E-7916
database_cross_reference: SNMI:C-51850
database_cross_reference: SNOMEDCT_US:372856003
database_cross_reference: SNOMEDCT_US:80165005
database_cross_reference: USPMG:MTHU000365
database_cross_reference: VANDF:4019782

Ketoconazole
type: Class
subclass of: Piperazines
MCID: MC00007226
PMOID: PMO:00018270
Subclass_of: Piperazines
Synonym: Apo-ketoconazole
Synonym: Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
Synonym: KCZ
Synonym: KETOCONAZOLE
Synonym: Ketoconazol
Synonym: Ketoconazole (product)
Synonym: Ketoconazole (substance)
Synonym: Ketoconazole [Chemical/Ingredient]
Synonym: Ketoconazole [gyn]
Synonym: Ketoconazole [gynaecological use]
Tree Number: T6.3.5.15.18
database_cross_reference: ATC:D01AC08
database_cross_reference: ATC:G01AF11
database_cross_reference: ATC:J02AB02
database_cross_reference: CHV:0000007076
database_cross_reference: CSP:1549-4550
database_cross_reference: DRUGBANK:DB01026
database_cross_reference: LCH_NW:sh89006385
database_cross_reference: LNC:LP15862-3
database_cross_reference: LNC:MTHU002299
database_cross_reference: MEDCIN:40351
database_cross_reference: MMSL:31001
database_cross_reference: MMSL:4945
database_cross_reference: MMSL:d00103
database_cross_reference: MSH:D007654
database_cross_reference: MTHSPL:R9400W927I
database_cross_reference: NCI:C605
database_cross_reference: NCI_DCP:20436
database_cross_reference: NCI_DTP:NSC0317629
database_cross_reference: NCI_FDA:R9400W927I
database_cross_reference: NCI_NCI-GLOSS:CDR0000045222
database_cross_reference: NDDF:002903
database_cross_reference: NDFRT:N0000007319
database_cross_reference: NDFRT:N0000147470
database_cross_reference: PDQ:CDR0000039488
database_cross_reference: RCD:eh4..
database_cross_reference: RCD:g45..
database_cross_reference: RCD:me6..
database_cross_reference: RCD:x02Lx
database_cross_reference: RCDAE:g45..
database_cross_reference: RXNORM:6135
database_cross_reference: SNMI:C-52B50
database_cross_reference: SNOMEDCT_US:324673001
database_cross_reference: SNOMEDCT_US:326240002
database_cross_reference: SNOMEDCT_US:332902002
database_cross_reference: SNOMEDCT_US:387216007
database_cross_reference: SNOMEDCT_US:40232005
database_cross_reference: USPMG:MTHU000391
database_cross_reference: VANDF:4019271

Lidoflazine
type: Class
subclass of: Piperazines
MCID: MC00007565
PMOID: PMO:00018271
Subclass_of: Piperazines
Synonym: 1-Piperazineacetamide, 4-(4,4-bis(4-fluorophenyl)butyl)-N-(2,6-dimethylphenyl)-
Synonym: LIDOFLAZINE
Synonym: Lidoflazine (product)
Synonym: Lidoflazine (substance)
Synonym: Lidoflazine [Chemical/Ingredient]
Synonym: lidoflazine
Tree Number: T6.3.5.15.19
database_cross_reference: ATC:C08EX01
database_cross_reference: LCH:U002687
database_cross_reference: LCH_NW:sh85076780
database_cross_reference: MSH:D008013
database_cross_reference: NCI:C81685
database_cross_reference: NCI_FDA:J4ZHN3HBTE
database_cross_reference: NDFRT:N0000167118
database_cross_reference: RCD:bl6..
database_cross_reference: RXNORM:6390
database_cross_reference: SNOMEDCT_US:319206000
database_cross_reference: SNOMEDCT_US:418865004

Pipobroman
type: Class
subclass of: Piperazines
MCID: MC00010240
PMOID: PMO:00018272
Subclass_of: Piperazines
Synonym: PIPOBROMAN
Synonym: Piperazine, 1,4-bis(3-bromo-1-oxopropyl)-
Synonym: Pipobroman (substance)
Synonym: Pipobroman [Chemical/Ingredient]
Synonym: pipobroman
Tree Number: T6.3.5.15.22
database_cross_reference: ATC:L01AX02
database_cross_reference: DRUGBANK:DB00236
database_cross_reference: MSH:D010885
database_cross_reference: NCI:C750
database_cross_reference: NCI_FDA:6Q99RDT97R
database_cross_reference: NDDF:002099
database_cross_reference: NDFRT:N0000006175
database_cross_reference: NDFRT:N0000147043
database_cross_reference: RXNORM:8347
database_cross_reference: SNMI:C-781B0
database_cross_reference: SNOMEDCT_US:24823004
database_cross_reference: VANDF:4018739

Piribedil
type: Class
subclass of: Piperazines
MCID: MC00010246
PMOID: PMO:00018273
Subclass_of: Piperazines
Synonym: PIRIBEDIL
Synonym: Piribedil (substance)
Synonym: Piribedil [Chemical/Ingredient]
Synonym: Piribendyl
Synonym: Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-
Synonym: piribedil
Tree Number: T6.3.5.15.23
database_cross_reference: ATC:N04BC08
database_cross_reference: CHV:0000009753
database_cross_reference: DRUGBANK:DB12478
database_cross_reference: MSH:D010891
database_cross_reference: NCI:C81082
database_cross_reference: NCI_FDA:DO22K1PRDJ
database_cross_reference: NDDF:005711
database_cross_reference: NDFRT:N0000167119
database_cross_reference: RXNORM:8353
database_cross_reference: SNOMEDCT_US:713435009

Prospidium
type: Class
subclass of: Spiro Compounds
subclass of: Piperazines
MCID: MC00010736
PMOID: PMO:00018274
Subclass_of: Piperazines
Subclass_of: Spiro Compounds
Synonym: 3,12-Bis(3-Chloro-2-Hydroxypropyl)-3,12-Diaza-6,9-Diazoniadispiro(5.2.5.2)Hexadecane
Synonym: 3,12-Bis(3-chloro-2-hydroxypropyl)-3,12-diaza-6,9- diazoniadispiro(5.2.5.2)hexadecane
Synonym: PROSPIDIUM
Synonym: Prospidin
Synonym: Prospidine
Synonym: Prospidium [Chemical/Ingredient]
Tree Number: T6.3.5.15.24
Tree Number: T6.4.4.6
database_cross_reference: MSH:D011447
database_cross_reference: NCI:C29333
database_cross_reference: NCI:C87755
database_cross_reference: NCI_FDA:7Y2M0915RZ
database_cross_reference: NDFRT:N0000167368

Trazodone
type: Class
subclass of: Piperazines
MCID: MC00013023
PMOID: PMO:00018275
Subclass_of: Piperazines
Synonym: 1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-
Synonym: 2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Synonym: Apo-trazodone D Tablets 150mg
Synonym: Apo-trazodone Tablets 100mg
Synonym: Apo-trazodone Tablets 50mg
Synonym: Beneficat
Synonym: Desirel
Synonym: Desyrel Dividose Tab 300mg
Synonym: Desyrel Dividose Tablet 150 mg
Synonym: Desyrel Tab 100mg
Tree Number: T6.3.5.15.27
database_cross_reference: AOD:0000020759
database_cross_reference: ATC:N06AX05
database_cross_reference: CCPSS:0035767
database_cross_reference: CHV:0000012498
database_cross_reference: DRUGBANK:DB00656
database_cross_reference: LNC:LP16297-1
database_cross_reference: LNC:MTHU005053
database_cross_reference: MEDCIN:340490
database_cross_reference: MMSL:d00395
database_cross_reference: MSH:D014196
database_cross_reference: MTHSPL:YBK48BXK30
database_cross_reference: NCI:C29510
database_cross_reference: NCI_FDA:YBK48BXK30
database_cross_reference: NDDF:004610
database_cross_reference: NDFRT:N0000007040
database_cross_reference: NDFRT:N0000148039
database_cross_reference: PSY:54152
database_cross_reference: RCD:x01B2
database_cross_reference: RXNORM:10737
database_cross_reference: SNMI:C-622F0
database_cross_reference: SNOMEDCT_US:372829000
database_cross_reference: SNOMEDCT_US:7336002
database_cross_reference: USPMG:MTHU000344
database_cross_reference: VANDF:4019954

Trimetazidine
type: Class
subclass of: Piperazines
MCID: MC00013110
PMOID: PMO:00018276
Subclass_of: Piperazines
Synonym: 1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride
Synonym: Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-
Synonym: TRIMETAZIDINE
Synonym: Trimetazidine (substance)
Synonym: Trimetazidine [Chemical/Ingredient]
Synonym: trimetazidine
Tree Number: T6.3.5.15.28
database_cross_reference: ATC:C01EB15
database_cross_reference: CHV:0000012570
database_cross_reference: DRUGBANK:DB09069
database_cross_reference: MSH:D014292
database_cross_reference: NCI:C76590
database_cross_reference: NCI_FDA:N9A0A0R9S8
database_cross_reference: NDDF:003771
database_cross_reference: NDFRT:N0000167121
database_cross_reference: RXNORM:10826
database_cross_reference: SNOMEDCT_US:703365009

Almitrine
type: Class
subclass of: Piperazines
subclass of: Triazines
MCID: MC00000597
PMOID: PMO:00018277
Subclass_of: Piperazines
Subclass_of: Triazines
Synonym: 1,3,5-Triazine-2,4-diamine, 6-(4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)-N,N'-di-2-propenyl-
Synonym: 2,4-Bis(allylamino)-6-(4-(bis(P-fluorophenyl)methyl)-1-piperazinyl)-S-triazine
Synonym: 2,4-Bis(allylamino)-6-(4-(bis(p-fluorophenyl)methyl)-1-piperazinyl)-s-triazine
Synonym: ALMITRINE
Synonym: Almitrin
Synonym: Almitrina
Synonym: Almitrine (substance)
Synonym: Almitrine [Chemical/Ingredient]
Synonym: Almitrinum
Synonym: almitrine
Tree Number: T6.3.5.15.29
Tree Number: T6.3.5.26.9
database_cross_reference: ATC:R07AB07
database_cross_reference: DRUGBANK:DB01430
database_cross_reference: MSH:D015765
database_cross_reference: NCI:C74241
database_cross_reference: NCI_FDA:9A1222NBG4
database_cross_reference: NDDF:003690
database_cross_reference: NDFRT:N0000167166
database_cross_reference: RXNORM:528
database_cross_reference: SNOMEDCT_US:418600009

Pipecuronium
type: Class
subclass of: Piperazines
MCID: MC00035091
PMOID: PMO:00018278
Subclass_of: Piperazines
Synonym: PIPECURONIUM
Synonym: Pipecurium
Synonym: Pipecuronium (product)
Synonym: Pipecuronium (substance)
Synonym: Pipecuronium [Chemical/Ingredient]
Synonym: Piperazinium, 4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl)
Synonym: pipecuronium
Tree Number: T6.3.5.15.30
database_cross_reference: DRUGBANK:DB01338
database_cross_reference: MMSL:d00956
database_cross_reference: MSH:D017300
database_cross_reference: NCI:C77368
database_cross_reference: NCI_FDA:1N3O74HM92
database_cross_reference: NDDF:013423
database_cross_reference: NDFRT:N0000006236
database_cross_reference: NDFRT:N0000147980
database_cross_reference: RXNORM:33742
database_cross_reference: SNOMEDCT_US:108455007
database_cross_reference: SNOMEDCT_US:373725008
database_cross_reference: VANDF:4019895

Diketopiperazines
type: Class
subclass of: Piperazines
MCID: MC00025092
PMOID: PMO:00018279
Subclass_of: Piperazines
Synonym: Diketopiperazine
Synonym: Diketopiperazine Compounds
Synonym: Diketopiperazines [Chemical/Ingredient]
Synonym: Piperazinediones
Tree Number: T6.3.5.15.34
database_cross_reference: MSH:D054659
database_cross_reference: NDFRT:N0000178590

Piperidines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00010236
PMOID: PMO:00018282
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Piperidines [Chemical/Ingredient]
Tree Number: T6.3.5.16
database_cross_reference: MSH:D010880
database_cross_reference: NDFRT:N0000007929

Alphaprodine
type: Class
subclass of: Piperidines
MCID: MC00000666
PMOID: PMO:00018283
Subclass_of: Piperidines
Synonym: 4-Piperidinol, 1,3-dimethyl-4-phenyl-, propanoate (ester), cis-
Synonym: ALPHAPRODINE
Synonym: Alphaprodine (substance)
Synonym: Alphaprodine [Chemical/Ingredient]
Synonym: alphaprodine
Synonym: dl-alpha-prodine
Tree Number: T6.3.5.16.1
database_cross_reference: DRUGBANK:DB13160
database_cross_reference: LNC:LP16022-3
database_cross_reference: LNC:MTHU015329
database_cross_reference: MSH:D000522
database_cross_reference: NCI:C83528
database_cross_reference: NCI_FDA:001O2254AC
database_cross_reference: NDDF:004621
database_cross_reference: NDFRT:N0000006607
database_cross_reference: NDFRT:N0000147694
database_cross_reference: RXNORM:594
database_cross_reference: SNM:E-7782
database_cross_reference: SNMI:C-60715
database_cross_reference: SNOMEDCT_US:52885008
database_cross_reference: VANDF:4019598

Fentanyl
type: Class
subclass of: Piperidines
MCID: MC00005031
PMOID: PMO:00018284
Subclass_of: Piperidines
Synonym: 1-Phenethyl-4-(N-phenylpropionamido)piperidine
Synonym: 1-phenethyl-4-N-propionylanilinopiperidine
Synonym: Abstral fentanyl
Synonym: Apo-fentanyl Matrix
Synonym: Co Fentanyl
Synonym: FENTANYL
Synonym: FentaNYL
Synonym: Fentanil
Synonym: Fentanila
Synonym: Fentanilo
Tree Number: T6.3.5.16.7
database_cross_reference: AOD:0000020731
database_cross_reference: ATC:N01AH01
database_cross_reference: ATC:N02AB03
database_cross_reference: CHV:0000004970
database_cross_reference: CSP:2332-6903
database_cross_reference: DRUGBANK:DB00813
database_cross_reference: LCH:U001759
database_cross_reference: LCH_NW:sh85047807
database_cross_reference: LNC:LP15167-7
database_cross_reference: LNC:MTHU002556
database_cross_reference: MEDCIN:302440
database_cross_reference: MEDCIN:40201
database_cross_reference: MMSL:4721
database_cross_reference: MMSL:64408
database_cross_reference: MMSL:d00233
database_cross_reference: MSH:D005283
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:UF599785JZ
database_cross_reference: NCI:C47994
database_cross_reference: NCI:C494
database_cross_reference: NCI_FDA:UF599785JZ
database_cross_reference: NDDF:003571
database_cross_reference: NDFRT:N0000007029
database_cross_reference: NDFRT:N0000147049
database_cross_reference: PSY:19613
database_cross_reference: RCD:o42..
database_cross_reference: RXNORM:4337
database_cross_reference: SNM:E-7789
database_cross_reference: SNMI:C-60650
database_cross_reference: SNOMEDCT_US:373492002
database_cross_reference: SNOMEDCT_US:40648001
database_cross_reference: USPMG:MTHU000021
database_cross_reference: VANDF:4018745

Flecainide
type: Class
subclass of: Piperidines
MCID: MC00005165
PMOID: PMO:00018287
Subclass_of: Piperidines
Synonym: Almarytm
Synonym: Auro-flecainide
Synonym: Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-
Synonym: FLECAINIDE
Synonym: Flecaine
Synonym: Flecainida
Synonym: Flecainide (product)
Synonym: Flecainide (substance)
Synonym: Flecainide [Chemical/Ingredient]
Synonym: Flecainidum
Tree Number: T6.3.5.16.8
database_cross_reference: ATC:C01BC04
database_cross_reference: CHV:0000005089
database_cross_reference: DRUGBANK:DB01195
database_cross_reference: LNC:LP16148-6
database_cross_reference: LNC:MTHU004259
database_cross_reference: MEDCIN:42125
database_cross_reference: MMSL:d00234
database_cross_reference: MSH:D005424
database_cross_reference: MTHSPL:K94FTS1806
database_cross_reference: NCI:C62029
database_cross_reference: NCI_DTP:NSC0719273
database_cross_reference: NCI_FDA:K94FTS1806
database_cross_reference: NCI_NCI-GLOSS:CDR0000045381
database_cross_reference: NDDF:004483
database_cross_reference: NDFRT:N0000006966
database_cross_reference: NDFRT:N0000147848
database_cross_reference: RCD:x01QJ
database_cross_reference: RXNORM:4441
database_cross_reference: SNMI:C-803F0
database_cross_reference: SNOMEDCT_US:372751001
database_cross_reference: SNOMEDCT_US:46576005
database_cross_reference: USPMG:MTHU000899
database_cross_reference: VANDF:4019757

Loperamide
type: Class
subclass of: Piperidines
MCID: MC00007671
PMOID: PMO:00018288
Subclass_of: Piperidines
Synonym: 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-
Synonym: 7 Select Anti Diarrheal
Synonym: Alti-loperamide - 2mg Caplet
Synonym: Anti-Diarrheal Loperamide HCl
Synonym: Anti-Diarrheal loperamide HCl
Synonym: Antidiarrheal Relief
Synonym: Apo-loperamide - Tab 2mg
Synonym: Berkley and Jensen Anti Diarrheal
Synonym: Care One Anti Diarrheal
Synonym: Care One anti diarrheal loperamide hydrochloride
Tree Number: T6.3.5.16.15
database_cross_reference: ATC:A07DA03
database_cross_reference: CHV:0000007542
database_cross_reference: DRUGBANK:DB00836
database_cross_reference: LCH:U002737
database_cross_reference: LCH_NW:sh85078329
database_cross_reference: LNC:LP18991-7
database_cross_reference: LNC:MTHU007262
database_cross_reference: MMSL:d01025
database_cross_reference: MSH:D008139
database_cross_reference: MTHSPL:6X9OC3H4II
database_cross_reference: NCI:C618
database_cross_reference: NCI_FDA:6X9OC3H4II
database_cross_reference: NDDF:004545
database_cross_reference: NDFRT:N0000007084
database_cross_reference: NDFRT:N0000147893
database_cross_reference: RCD:x019e
database_cross_reference: RXNORM:6468
database_cross_reference: SNOMEDCT_US:116726003
database_cross_reference: SNOMEDCT_US:387040009
database_cross_reference: USPMG:MTHU001221
database_cross_reference: VANDF:4019804

Mepivacaine
type: Class
subclass of: Piperidines
MCID: MC00008081
PMOID: PMO:00018289
Subclass_of: Piperidines
Synonym: (+-)-1-Methyl-2',6'-pipecoloxylidide
Synonym: 1-methyl-2',6'-pipecoloxylidide
Synonym: 2% Polocaine Dental With Levonordefrin 1:20,000
Synonym: 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-
Synonym: 3% Polocaine Dental
Synonym: Carbocaine Liq 2%
Synonym: Carbocaine 1%
Synonym: Carbocaine 2%
Synonym: Carbocaine 3%
Synonym: Carbocaine Inj Liq 10mg/ml
Tree Number: T6.3.5.16.16
database_cross_reference: ATC:N01BB03
database_cross_reference: CHV:0000007971
database_cross_reference: CSP:2332-6342
database_cross_reference: DRUGBANK:DB00961
database_cross_reference: LNC:LP14721-2
database_cross_reference: LNC:MTHU001813
database_cross_reference: MMSL:d01398
database_cross_reference: MSH:D008619
database_cross_reference: MTHSPL:B6E06QE59J
database_cross_reference: NCI:C61831
database_cross_reference: NCI_FDA:B6E06QE59J
database_cross_reference: NDDF:004567
database_cross_reference: NDFRT:N0000006401
database_cross_reference: NDFRT:N0000147904
database_cross_reference: RXNORM:6759
database_cross_reference: SNM:E-7032
database_cross_reference: SNMI:C-6B050
database_cross_reference: SNOMEDCT_US:370291008
database_cross_reference: SNOMEDCT_US:391673008
database_cross_reference: SNOMEDCT_US:59560006
database_cross_reference: VANDF:4019815

Minoxidil
type: Class
subclass of: Piperidines
subclass of: Pyrimidines
MCID: MC00008332
PMOID: PMO:00018290
Subclass_of: Piperidines
Subclass_of: Pyrimidines
Synonym: 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine
Synonym: 2,4-Diamino-6-piperidinopyrimidine 3-oxide
Synonym: 2,4-Pyrimidinediamine, 6-(1-Piperidinyl)-, 3-Oxide
Synonym: 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
Synonym: 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide
Synonym: Apo-gain Liq 20mg/ml
Synonym: Avogain
Synonym: BOSLEY PROFESSIONAL STRENGTH HAIR REGROWTH TREATMENT Regular Strength For Men
Synonym: BOSLEY PROFESSIONAL STRENGTH HAIR REGROWTH TREATMENT Regular Strength For Women
Synonym: Basic Care Hair Regrowth
Tree Number: T6.3.5.16.18
Tree Number: T6.3.5.21.10
database_cross_reference: ATC:C02DC01
database_cross_reference: ATC:D11AX01
database_cross_reference: CHV:0000008169
database_cross_reference: CSP:2517-6235
database_cross_reference: DRUGBANK:DB00350
database_cross_reference: LCH_NW:sh94006275
database_cross_reference: LNC:LP19149-1
database_cross_reference: LNC:MTHU007401
database_cross_reference: MEDCIN:41902
database_cross_reference: MMSL:5119
database_cross_reference: MMSL:7147
database_cross_reference: MMSL:d00135
database_cross_reference: MSH:D008914
database_cross_reference: MTHSPL:5965120SH1
database_cross_reference: NCI:C47623
database_cross_reference: NCI_DCP:30293
database_cross_reference: NCI_FDA:5965120SH1
database_cross_reference: NDDF:000637
database_cross_reference: NDFRT:N0000007452
database_cross_reference: NDFRT:N0000146416
database_cross_reference: RCD:be3..
database_cross_reference: RCD:mb3..
database_cross_reference: RXNORM:6984
database_cross_reference: SNM:E-7699
database_cross_reference: SNMI:C-811C0
database_cross_reference: SNOMEDCT_US:332754004
database_cross_reference: SNOMEDCT_US:387272001
database_cross_reference: SNOMEDCT_US:49577002
database_cross_reference: USPMG:MTHU001065
database_cross_reference: VANDF:4018077

Pempidine
type: Class
subclass of: Piperidines
MCID: MC00009803
PMOID: PMO:00018291
Subclass_of: Piperidines
Synonym: PEMPIDINE
Synonym: Pempidine [Chemical/Ingredient]
Synonym: Piperidine, 1,2,2,6,6-pentamethyl-
Synonym: pempidine
Tree Number: T6.3.5.16.20
database_cross_reference: MSH:D010393
database_cross_reference: NCI:C66335
database_cross_reference: NCI_FDA:N5I18JI9D6
database_cross_reference: NDDF:001773
database_cross_reference: NDFRT:N0000167214

Penfluridol
type: Class
subclass of: Piperidines
MCID: MC00009806
PMOID: PMO:00018292
Subclass_of: Piperidines
Synonym: 4-Piperidinol, 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)-
Synonym: PENFLURIDOL
Synonym: Penfluridol (substance)
Synonym: Penfluridol [Chemical/Ingredient]
Synonym: penfluridol
Tree Number: T6.3.5.16.21
database_cross_reference: AOD:0000020762
database_cross_reference: ATC:N05AG03
database_cross_reference: CHV:0000009414
database_cross_reference: LCH:U003519
database_cross_reference: LCH_NW:sh85099392
database_cross_reference: LNC:LP199572-1
database_cross_reference: LNC:MTHU050998
database_cross_reference: MSH:D010395
database_cross_reference: NCI:C90843
database_cross_reference: NCI_FDA:25TLU22Q8H
database_cross_reference: NDDF:005285
database_cross_reference: NDFRT:N0000167198
database_cross_reference: RXNORM:7974
database_cross_reference: SNOMEDCT_US:710292006

Perhexiline
type: Class
subclass of: Piperidines
MCID: MC00009892
PMOID: PMO:00018293
Subclass_of: Piperidines
Synonym: (+)-2-(2,2-Dicyclohexylethyl)piperidine
Synonym: (-)-2-(2,2-Dicyclohexylethyl)piperidine
Synonym: 2-(2,2-Dicyclohexylethyl)piperidine
Synonym: Perhexilene
Synonym: Perhexilina
Synonym: Perhexiline (product)
Synonym: Perhexiline (substance)
Synonym: Perhexiline [Chemical/Ingredient]
Synonym: Perhexilinum
Synonym: Perhexilline
Tree Number: T6.3.5.16.22
database_cross_reference: AOD:0000020763
database_cross_reference: ATC:C08EX02
database_cross_reference: CHV:0000009475
database_cross_reference: DRUGBANK:DB01074
database_cross_reference: LCH:U003544
database_cross_reference: LCH_NW:sh85099846
database_cross_reference: LNC:LP20803-0
database_cross_reference: LNC:LP70328-7
database_cross_reference: LNC:MTHU012163
database_cross_reference: MSH:D010480
database_cross_reference: NDDF:005713
database_cross_reference: NDFRT:N0000167208
database_cross_reference: RXNORM:8050
database_cross_reference: SNOMEDCT_US:421776000
database_cross_reference: SNOMEDCT_US:421817009

Phencyclidine
type: Class
subclass of: Piperidines
MCID: MC00010002
PMOID: PMO:00018294
Subclass_of: Piperidines
Synonym: 1-(1-Phenylcyclohexyl)piperidine
Synonym: Angel Dust
Synonym: Angel dust
Synonym: Dust, Angel
Synonym: PCP
Synonym: PCP - Phencyclidine
Synonym: PHENCYCLIDINE
Synonym: Phencyclidine (substance)
Synonym: Phencyclidine [Chemical/Ingredient]
Synonym: Phencyclidine substan of abuse
Tree Number: T6.3.5.16.23
database_cross_reference: AOD:0000000752
database_cross_reference: AOD:0000021343
database_cross_reference: CHV:0000009591
database_cross_reference: CSP:2332-7464
database_cross_reference: DRUGBANK:DB03575
database_cross_reference: ICD10CM:F16
database_cross_reference: LCH:U003606
database_cross_reference: LCH_NW:sh85100665
database_cross_reference: LNC:LA15874-3
database_cross_reference: LNC:LP14566-1
database_cross_reference: LNC:MTHU001586
database_cross_reference: MMSL:d03880
database_cross_reference: MSH:D010622
database_cross_reference: MTH:U002157
database_cross_reference: NCI:C738
database_cross_reference: NCI_FDA:J1DOI7UV76
database_cross_reference: NDFRT:N0000167207
database_cross_reference: NDFRT:N0000176149
database_cross_reference: PSY:37025
database_cross_reference: PSY:38125
database_cross_reference: RCD:Ub18M
database_cross_reference: SNM:E-793X
database_cross_reference: SNMI:C-6A180
database_cross_reference: SNOMEDCT_US:228996005
database_cross_reference: SNOMEDCT_US:9721008
database_cross_reference: VANDF:4027426

Piperidones
type: Class
subclass of: Piperidines
MCID: MC00010237
PMOID: PMO:00018295
Subclass_of: Piperidines
Synonym: Piperidones [Chemical/Ingredient]
Synonym: piperidone
Tree Number: T6.3.5.16.25
database_cross_reference: AOD:0000020764
database_cross_reference: LCH_NW:sh90001414
database_cross_reference: MSH:D010881
database_cross_reference: NDFRT:N0000007930

Trihexyphenidyl
type: Class
subclass of: Piperidines
MCID: MC00013094
PMOID: PMO:00018300
Subclass_of: Piperidines
Synonym: (RS)-1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol
Synonym: 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-
Synonym: Altant
Synonym: Aparkane Tab 2mg
Synonym: Aparkane Tab 5mg
Synonym: Artane Elx 2mg/5ml
Synonym: Artane Tab 2mg
Synonym: Artane Tab 5mg
Synonym: Artine
Synonym: Atan
Tree Number: T6.3.5.16.27
database_cross_reference: ATC:N04AA01
database_cross_reference: CHV:0000012565
database_cross_reference: CSP:2332-6342
database_cross_reference: DRUGBANK:DB00376
database_cross_reference: LNC:LP14553-9
database_cross_reference: LNC:MTHU001575
database_cross_reference: MEDCIN:340494
database_cross_reference: MMSL:d00970
database_cross_reference: MSH:D014282
database_cross_reference: MTHSPL:6RC5V8B7PO
database_cross_reference: NCI:C61988
database_cross_reference: NCI_FDA:6RC5V8B7PO
database_cross_reference: NDDF:004664
database_cross_reference: NDFRT:N0000006156
database_cross_reference: NDFRT:N0000148044
database_cross_reference: PSY:54270
database_cross_reference: RCD:x01DS
database_cross_reference: RXNORM:10811
database_cross_reference: SNM:E-7596
database_cross_reference: SNMI:C-67550
database_cross_reference: SNOMEDCT_US:2190009
database_cross_reference: SNOMEDCT_US:387120000
database_cross_reference: USPMG:MTHU000601
database_cross_reference: VANDF:4019959

Ritanserin
type: Class
subclass of: Piperidines
MCID: MC00043242
PMOID: PMO:00018301
Subclass_of: Piperidines
Synonym: 5H-Thiazolo(3,2-a)Pyrimidin-5-One, 6-(2-(4-(Bis(4-Fluorophenyl)Methylene)-1-Piperidinyl)Ethyl)-7-Methyl-
Synonym: 5H-Thiazolo(3,2-a)pyrimidin-5-one, 6-(2-(4-(bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-
Synonym: 6-(2-(4-(Bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo(3,2-a)pyrimidin-5-one
Synonym: 6-(2-(4-(Bis(P-Fluorophenyl)Methylene)-Piperidino)Ethyl)-7-Methyl-5h-Thiazolo-(3,2-A)Pyrimidin-5-One
Synonym: RITANSERIN
Synonym: Ritanserin [Chemical/Ingredient]
Synonym: ritanserin
Tree Number: T6.3.5.16.29
database_cross_reference: AOD:0000020804
database_cross_reference: DRUGBANK:DB12693
database_cross_reference: MSH:D016713
database_cross_reference: NCI:C95217
database_cross_reference: NCI_FDA:145TFV465S
database_cross_reference: NDFRT:N0000167205
database_cross_reference: NDFRT:N0000171793
database_cross_reference: PSY:44665
database_cross_reference: VANDF:4025265

Paroxetine
type: Class
subclass of: Piperidines
MCID: MC00034328
PMOID: PMO:00018302
Subclass_of: Piperidines
Synonym: (3S-trans)-3-((1,3-Benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
Synonym: Act Paroxetine
Synonym: Apo-paroxetine
Synonym: Auro-paroxetine
Synonym: Bio-paroxetine
Synonym: Dom-paroxetine
Synonym: Ipg-paroxetine
Tree Number: T6.3.5.16.30
database_cross_reference: AOD:0000020761
database_cross_reference: ATC:N06AB05
database_cross_reference: CHV:0000014582
database_cross_reference: CSP:4007-0096
database_cross_reference: DRUGBANK:DB00715
database_cross_reference: LCH_NW:sh2008001313
database_cross_reference: LNC:LP17979-3
database_cross_reference: LNC:MTHU004267
database_cross_reference: MMSL:29631
database_cross_reference: MMSL:d03157
database_cross_reference: MSH:D017374
database_cross_reference: MTHSPL:41VRH5220H
database_cross_reference: NCI:C61879
database_cross_reference: NCI_FDA:41VRH5220H
database_cross_reference: NDDF:004016
database_cross_reference: NDFRT:N0000006422
database_cross_reference: NDFRT:N0000148335
database_cross_reference: PSY:36770
database_cross_reference: RCD:da6..
database_cross_reference: RXNORM:32937
database_cross_reference: SNMI:C-62340
database_cross_reference: SNOMEDCT_US:321963000
database_cross_reference: SNOMEDCT_US:372595009
database_cross_reference: SNOMEDCT_US:96214003
database_cross_reference: USPMG:MTHU000310
database_cross_reference: VANDF:4020815

Pyrans
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00010981
PMOID: PMO:00018303
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Pyran
Synonym: Pyrans [Chemical/Ingredient]
Synonym: pyran
Tree Number: T6.3.5.17
database_cross_reference: AOD:0000020767
database_cross_reference: CSP:2188-2342
database_cross_reference: LCH:U003964
database_cross_reference: LCH_NW:sh85109306
database_cross_reference: MSH:D011714
database_cross_reference: NDFRT:N0000008141

Aurovertins
type: Class
subclass of: Pyrans
MCID: MC00001387
PMOID: PMO:00018304
Subclass_of: Pyrans
Synonym: Aurovertin
Synonym: Aurovertins [Chemical/Ingredient]
Tree Number: T6.3.5.17.1
database_cross_reference: MSH:D001313
database_cross_reference: NDFRT:N0000167172

Patulin
type: Class
subclass of: Pyrans
subclass of: PMO:00024389
MCID: MC00009774
PMOID: PMO:00018305
Subclass_of: Mycotoxins
Subclass_of: Pyrans
Synonym: 4H-Furo(3,2-c)pyran-2(6H)-one, 4-hydroxy-
Synonym: Patulin (substance)
Synonym: Patulin [Chemical/Ingredient]
Synonym: patulin
Tree Number: T6.13.8.6.9
Tree Number: T6.3.5.17.5
database_cross_reference: AOD:0000020768
database_cross_reference: MSH:D010365
database_cross_reference: NDFRT:N0000171411
database_cross_reference: SNMI:C-30827
database_cross_reference: SNOMEDCT_US:70069007

Pyran Copolymer
type: Class
subclass of: Pyrans
subclass of: Polymers
MCID: MC00010980
PMOID: PMO:00018306
Subclass_of: Polymers
Subclass_of: Pyrans
Synonym: 2,5-Furandione, polymer with 1,1'-oxybis(ethene)
Synonym: Copolymer, Pyran
Synonym: DIVEMA
Synonym: Divinyl Ether Maleic Anhydride Copolymer
Synonym: Maleic Anhydride Divinyl Ether
Synonym: Maleic Anhydride Vinyl Ether
Synonym: Pyran Copolymer [Chemical/Ingredient]
Synonym: Vinyl Ether Maleic Anhydride Polymer
Tree Number: T6.14.9.12
Tree Number: T6.3.5.17.6
Tree Number: T6.5.2.14
database_cross_reference: MSH:D011713
database_cross_reference: NDFRT:N0000171550

Pyrones
type: Class
subclass of: Pyrans
MCID: MC00011025
PMOID: PMO:00018307
Subclass_of: Pyrans
Synonym: Pyrone
Synonym: Pyrone (substance)
Synonym: Pyrones [Chemical/Ingredient]
Synonym: pyrone
Synonym: pyrones
Tree Number: T6.3.5.17.7
database_cross_reference: CHV:0000010463
database_cross_reference: CSP:2188-2693
database_cross_reference: MSH:D011753
database_cross_reference: NDFRT:N0000007590
database_cross_reference: SNOMEDCT_US:425977005

Pyrazines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00010986
PMOID: PMO:00018308
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Pyrazines [Chemical/Ingredient]
Tree Number: T6.3.5.18
database_cross_reference: LCH_NW:sh2007003956
database_cross_reference: MSH:D011719
database_cross_reference: NDFRT:N0000007565

Amiloride
type: Class
subclass of: Pyrazines
MCID: MC00000725
PMOID: PMO:00018309
Subclass_of: Pyrazines
Synonym: 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
Synonym: AMILORIDE
Synonym: Alti-amiloride Hctz
Synonym: Ami-hydro Tab
Synonym: Amilorid
Synonym: Amilorida
Synonym: Amiloride (product)
Synonym: Amiloride (substance)
Synonym: Amiloride Hydrochloride Tablets, USP
Synonym: Amiloride [Chemical/Ingredient]
Tree Number: T6.3.5.18.4
database_cross_reference: ATC:C03DB01
database_cross_reference: CHV:0000001003
database_cross_reference: CSP:2507-2912
database_cross_reference: DRUGBANK:DB00594
database_cross_reference: LCH:U000189
database_cross_reference: LCH_NW:sh85004476
database_cross_reference: LNC:LP16024-9
database_cross_reference: LNC:MTHU006775
database_cross_reference: MEDCIN:340336
database_cross_reference: MMSL:d00169
database_cross_reference: MSH:D000584
database_cross_reference: MTHSPL:7DZO8EB0Z3
database_cross_reference: NCI:C61633
database_cross_reference: NCI_DCP:01107
database_cross_reference: NCI_FDA:7DZO8EB0Z3
database_cross_reference: NDDF:004861
database_cross_reference: NDFRT:N0000006772
database_cross_reference: NDFRT:N0000147699
database_cross_reference: RCD:x01Qu
database_cross_reference: RXNORM:644
database_cross_reference: SNMI:C-72410
database_cross_reference: SNOMEDCT_US:387503008
database_cross_reference: SNOMEDCT_US:87395005
database_cross_reference: USPMG:MTHU000973
database_cross_reference: VANDF:4019603

Pyrazinamide
type: Class
subclass of: Pyrazines
MCID: MC00010985
PMOID: PMO:00018310
Subclass_of: Pyrazines
Synonym: 2-carbamylpyrazine
Synonym: 2-pyrazinecarboxamide
Synonym: PYRAZINAMIDE
Synonym: Pdp-pyrazinamide
Synonym: Piraldina
Synonym: Pirazinamida
Synonym: Pirazinamide
Synonym: Prazina
Synonym: Pyrafat
Synonym: Pyrazide
Tree Number: T6.3.5.18.5
database_cross_reference: ATC:J04AK01
database_cross_reference: CHV:0000010446
database_cross_reference: CSP:2507-1978
database_cross_reference: DRUGBANK:DB00339
database_cross_reference: LCH_NW:sh2007003976
database_cross_reference: LNC:LP15007-5
database_cross_reference: LNC:MTHU001493
database_cross_reference: MEDCIN:40364
database_cross_reference: MMSL:2368
database_cross_reference: MMSL:5390
database_cross_reference: MMSL:d00117
database_cross_reference: MSH:D011718
database_cross_reference: MTHSPL:2KNI5N06TI
database_cross_reference: NCI:C29395
database_cross_reference: NCI_FDA:2KNI5N06TI
database_cross_reference: NDDF:002849
database_cross_reference: NDFRT:N0000006003
database_cross_reference: NDFRT:N0000146266
database_cross_reference: RCD:ed5..
database_cross_reference: RXNORM:8987
database_cross_reference: SNM:E-7345
database_cross_reference: SNMI:C-55270
database_cross_reference: SNOMEDCT_US:13592004
database_cross_reference: SNOMEDCT_US:387076005
database_cross_reference: USPMG:MTHU000454
database_cross_reference: VANDF:4017915

Pyridazines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00010990
PMOID: PMO:00018311
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Pyridazines [Chemical/Ingredient]
Tree Number: T6.3.5.19
database_cross_reference: LCH_NW:sh85109330
database_cross_reference: MSH:D011724
database_cross_reference: NDFRT:N0000008145

Luminol
type: Class
subclass of: Pyridazines
MCID: MC00007699
PMOID: PMO:00018312
Subclass_of: Pyridazines
Synonym: 1,4-Phthalazinedione, 5-amino-2,3-dihydro-
Synonym: Luminol [Chemical/Ingredient]
Synonym: luminol
Tree Number: T6.3.5.19.1
database_cross_reference: CHV:0000007563
database_cross_reference: CSP:4000-0160
database_cross_reference: MSH:D008165
database_cross_reference: NDFRT:N0000167112

Maleic Hydrazide
type: Class
subclass of: Pyridazines
MCID: MC00007854
PMOID: PMO:00018313
Subclass_of: Pyridazines
Synonym: 3,6-Pyridazinedione, 1,2-dihydro-
Synonym: Acid Hydrazide, Maleic
Synonym: Hydrazide, Maleic
Synonym: Hydrazide, Maleic Acid
Synonym: Maleic Acid Hydrazide
Synonym: Maleic Hydrazide [Chemical/Ingredient]
Synonym: Maleic hydrazide
Synonym: Maleic hydrazide (substance)
Tree Number: T6.3.5.19.2
database_cross_reference: LCH_NW:sh2007003957
database_cross_reference: MSH:D008300
database_cross_reference: NDFRT:N0000167111
database_cross_reference: SNM:E-6495
database_cross_reference: SNMI:C-23547
database_cross_reference: SNOMEDCT_US:49444004

Phthalazines
type: Class
subclass of: Pyridazines
MCID: MC00010176
PMOID: PMO:00018314
Subclass_of: Pyridazines
Synonym: Phthalazines [Chemical/Ingredient]
Tree Number: T6.3.5.19.3
database_cross_reference: MSH:D010793
database_cross_reference: NDFRT:N0000007752

Cilazapril
type: Class
subclass of: Pyridazines
MCID: MC00023141
PMOID: PMO:00018317
Subclass_of: Pyridazines
Synonym: (1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic Acid 9-ethyl Ester Monohydrate
Synonym: 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, monohydrate, (1S-(1alpha,9alpha(R*)))-
Synonym: Apo-cilazapril
Synonym: Apo-cilazapril/hctz
Synonym: CILAZAPRIL
Synonym: CILAZAPRIL MONOHYDRATE
Synonym: Cilazapril (product)
Synonym: Cilazapril (substance)
Synonym: Cilazapril Hydrate
Synonym: Cilazapril Monohydrate
Tree Number: T6.3.5.19.4
database_cross_reference: ATC:C09AA08
database_cross_reference: CHV:0000013747
database_cross_reference: DRUGBANK:DB01340
database_cross_reference: MEDCIN:197613
database_cross_reference: MSH:D017315
database_cross_reference: NCI:C76133
database_cross_reference: NCI_FDA:19KW7PI29F
database_cross_reference: NDDF:003950
database_cross_reference: NDFRT:N0000167110
database_cross_reference: NDFRT:N0000171771
database_cross_reference: RCD:bi8..
database_cross_reference: RXNORM:21102
database_cross_reference: SNOMEDCT_US:318913001
database_cross_reference: SNOMEDCT_US:395947008
database_cross_reference: VANDF:4025239

Pyridines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00010992
PMOID: PMO:00018318
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Pyridine
Synonym: Pyridines [Chemical/Ingredient]
Synonym: pyridine
Synonym: pyridines
Tree Number: T6.3.5.20
database_cross_reference: CHV:0000010451
database_cross_reference: CSP:2510-9438
database_cross_reference: LNC:LP18097-3
database_cross_reference: LNC:MTHU003382
database_cross_reference: MSH:D011725
database_cross_reference: MTH:U002208
database_cross_reference: NDFRT:N0000007570

Atazanavir Sulfate
type: Class
subclass of: Pyridines
subclass of: PMO:00021376
MCID: MC00401222
PMOID: PMO:00018319
Subclass_of: Oligopeptides
Subclass_of: Pyridines
Synonym: ATAZANAVIR SO4
Synonym: ATAZANAVIR SULFATE
Synonym: Atazanavir Sulfate [Chemical/Ingredient]
Synonym: Atazanavir sulfate
Synonym: Atazanavir sulfate (product)
Synonym: Atazanavir sulfate (substance)
Synonym: Atazanavir sulphate
Synonym: atazanavir (as sulfate)
Synonym: atazanavir sulfate
Synonym: atazanavir sulfate (medication)
Tree Number: T6.10.2.13.1
Tree Number: T6.3.5.20.1
database_cross_reference: MEDCIN:258086
database_cross_reference: MMSL:17380
database_cross_reference: MMSL:30601
database_cross_reference: MSH:D000069446
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:4MT4VIE29P
database_cross_reference: NCI:C28835
database_cross_reference: NCI_FDA:4MT4VIE29P
database_cross_reference: NDDF:000539
database_cross_reference: NDFRT:N0000148815
database_cross_reference: NDFRT:N0000191946
database_cross_reference: RXNORM:358299
database_cross_reference: SNOMEDCT_US:404837001
database_cross_reference: SNOMEDCT_US:404838006
database_cross_reference: SNOMEDCT_US:413591007
database_cross_reference: USPMG:MTHU000675
database_cross_reference: VANDF:4021397

Betahistine
type: Class
subclass of: Pyridines
MCID: MC00001691
PMOID: PMO:00018322
Subclass_of: Pyridines
Synonym: 2-(beta-Methylaminoethyl)pyridine
Synonym: 2-Pyridineethanamine, N-methyl-
Synonym: 2-[2-(Methylamino)ethyl]pyridine
Synonym: Act Betahistine
Synonym: Apo-betahistine
Synonym: Auro-betahistine
Synonym: BETAHISTINE
Synonym: Betahistina
Synonym: Betahistine (product)
Synonym: Betahistine (substance)
Tree Number: T6.3.5.20.5
database_cross_reference: ATC:N07CA01
database_cross_reference: CHV:0000001832
database_cross_reference: DRUGBANK:DB06698
database_cross_reference: MSH:D001621
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C83554
database_cross_reference: NCI_FDA:X32KK4201D
database_cross_reference: NDDF:004531
database_cross_reference: NDDF:006923
database_cross_reference: NDFRT:N0000167237
database_cross_reference: NDFRT:N0000190653
database_cross_reference: RCD:x01RN
database_cross_reference: RXNORM:1511
database_cross_reference: SNOMEDCT_US:350631001
database_cross_reference: SNOMEDCT_US:418067008
database_cross_reference: VANDF:4033254

Clopidol
type: Class
subclass of: Pyridines
MCID: MC00002975
PMOID: PMO:00018323
Subclass_of: Pyridines
Synonym: 3,5-Dichloro-2,6-dimethyl-4-pyridinol
Synonym: 4-Pyridinol, 3,5-dichloro-2,6-dimethyl-
Synonym: CLOPIDOL
Synonym: Clopidol (substance)
Synonym: Clopidol [Chemical/Ingredient]
Synonym: Clopindol
Synonym: Metichlorpindol
Synonym: Meticlorpindol
Tree Number: T6.3.5.20.7
database_cross_reference: MSH:D003007
database_cross_reference: MTHSPL:8J763HFF5N
database_cross_reference: NCI:C76417
database_cross_reference: NCI_FDA:8J763HFF5N
database_cross_reference: NDFRT:N0000167223
database_cross_reference: RXNORM:1367179
database_cross_reference: SNMI:C-56D30
database_cross_reference: SNOMEDCT_US:96154009

Dihydropyridines
type: Class
subclass of: Pyridines
MCID: MC00003933
PMOID: PMO:00018324
Subclass_of: Pyridines
Synonym: Dihydropyridine
Synonym: Dihydropyridines [Chemical/Ingredient]
Synonym: dihydropyridine
Synonym: dihydropyridines
Tree Number: T6.3.5.20.8
database_cross_reference: CHV:0000003952
database_cross_reference: LCH:U001400
database_cross_reference: LCH_NW:sh85037998
database_cross_reference: MSH:D004095
database_cross_reference: MTH:U000669
database_cross_reference: MTH:U001864
database_cross_reference: NDFRT:N0000007556

Disopyramide
type: Class
subclass of: Pyridines
MCID: MC00004047
PMOID: PMO:00018335
Subclass_of: Pyridines
Synonym: 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-
Synonym: DISOPYRAMIDE
Synonym: Dicorantil
Synonym: Diisopyramide
Synonym: Disopiramida
Synonym: Disopyramide (product)
Synonym: Disopyramide (substance)
Synonym: Disopyramide [Chemical/Ingredient]
Synonym: Disopyramide product
Synonym: Disopyramidum
Tree Number: T6.3.5.20.10
database_cross_reference: ATC:C01BA03
database_cross_reference: CHV:0000004025
database_cross_reference: CSP:2509-4924
database_cross_reference: DRUGBANK:DB00280
database_cross_reference: LCH:U001426
database_cross_reference: LCH_NW:sh85038445
database_cross_reference: LNC:LP16118-9
database_cross_reference: LNC:MTHU003353
database_cross_reference: MMSL:d00214
database_cross_reference: MSH:D004206
database_cross_reference: MTHSPL:GFO928U8MQ
database_cross_reference: NCI:C61730
database_cross_reference: NCI_FDA:GFO928U8MQ
database_cross_reference: NDDF:000623
database_cross_reference: NDFRT:N0000005784
database_cross_reference: NDFRT:N0000147821
database_cross_reference: RCD:bc2..
database_cross_reference: RXNORM:3541
database_cross_reference: SNM:E-7675
database_cross_reference: SNMI:C-803B0
database_cross_reference: SNOMEDCT_US:372844004
database_cross_reference: SNOMEDCT_US:76759004
database_cross_reference: USPMG:MTHU000897
database_cross_reference: VANDF:4019729

Doxylamine
type: Class
subclass of: Pyridines
MCID: MC00004168
PMOID: PMO:00018336
Subclass_of: Pyridines
Synonym: 2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine
Synonym: 2-Dimethylaminoethoxyphenylmethyl-2-picoline
Synonym: 7 Select Night Time Relief
Synonym: 7 Select Sleep Aid
Synonym: ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE and DOXYLAMINE SUCCINATE
Synonym: ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and DOXYLAMINE SUCCINATE
Synonym: Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HCl
Synonym: Acetaminophen Dextromethorphan Hydrobromide Doxylamine Succinate Phenylephrine Hydrochloride
Synonym: Alka-Seltzer Plus Day and Night Cold and Flu Formula
Synonym: Alka-Seltzer Plus Day and Night Multi-Symptom Cold and Flu Formula
Tree Number: T6.3.5.20.11
database_cross_reference: ATC:R06AA09
database_cross_reference: CHV:0000004106
database_cross_reference: DRUGBANK:DB00366
database_cross_reference: LNC:LP16124-7
database_cross_reference: LNC:MTHU006976
database_cross_reference: MEDCIN:340397
database_cross_reference: MMSL:d03154
database_cross_reference: MSH:D004319
database_cross_reference: MTHSPL:95QB77JKPL
database_cross_reference: NCI:C61738
database_cross_reference: NCI_FDA:95QB77JKPL
database_cross_reference: NDDF:004789
database_cross_reference: NDFRT:N0000008027
database_cross_reference: NDFRT:N0000147830
database_cross_reference: RXNORM:3642
database_cross_reference: SNM:E-8851
database_cross_reference: SNMI:C-51480
database_cross_reference: SNOMEDCT_US:412380009
database_cross_reference: SNOMEDCT_US:44068004
database_cross_reference: VANDF:4019738

Metyrapone
type: Class
subclass of: Pyridines
MCID: MC00008267
PMOID: PMO:00018337
Subclass_of: Pyridines
Synonym: 1-Propanone, 2-methyl-1,2-di-3-pyridinyl-
Synonym: 2-Methyl-1,2-di-3-pyridinyl-1-propanone
Synonym: METYRAPONE
Synonym: Methbipyranone
Synonym: Methopyrapone
Synonym: Metirapona
Synonym: Metyrapone (product)
Synonym: Metyrapone (substance)
Synonym: Metyrapone [Chemical/Ingredient]
Synonym: Metyraponum
Tree Number: T6.3.5.20.13
database_cross_reference: ATC:V04CD01
database_cross_reference: CHV:0000008075
database_cross_reference: CSP:2511-0453
database_cross_reference: DRUGBANK:DB01011
database_cross_reference: LNC:LP32699-8
database_cross_reference: LNC:LP57518-0
database_cross_reference: LNC:MTHU020103
database_cross_reference: MEDCIN:41037
database_cross_reference: MMSL:5107
database_cross_reference: MMSL:d00592
database_cross_reference: MSH:D008797
database_cross_reference: MTHSPL:ZS9KD92H6V
database_cross_reference: NCI:C47619
database_cross_reference: NCI_DCP:02127
database_cross_reference: NCI_FDA:ZS9KD92H6V
database_cross_reference: NDDF:002120
database_cross_reference: NDFRT:N0000005777
database_cross_reference: NDFRT:N0000147091
database_cross_reference: RCD:fq2..
database_cross_reference: RXNORM:6923
database_cross_reference: SNM:E-8107
database_cross_reference: SNMI:C-B0145
database_cross_reference: SNOMEDCT_US:395794007
database_cross_reference: SNOMEDCT_US:53848009
database_cross_reference: VANDF:4018788

Nicotinyl Alcohol
type: Class
subclass of: Pyridines
MCID: MC00008891
PMOID: PMO:00018338
Subclass_of: Pyridines
Synonym: 3 Hydroxymethylpyridine
Synonym: 3-Hydroxymethylpyridine
Synonym: 3-Pyridinemethanol
Synonym: 3-pyridinemethanol
Synonym: Alcohol, Nicotinic
Synonym: Alcohol, Nicotinyl
Synonym: NICOTINYL ALCOHOL
Synonym: Nicotinic Alcohol
Synonym: Nicotinic alcohol
Synonym: Nicotinyl Alcohol [Chemical/Ingredient]
Tree Number: T6.3.5.20.17
database_cross_reference: ATC:C04AC02
database_cross_reference: ATC:C10AD05
database_cross_reference: DRUGBANK:DB04145
database_cross_reference: MEDCIN:40637
database_cross_reference: MSH:D009540
database_cross_reference: NCI:C61860
database_cross_reference: NCI_FDA:9TF312056Y
database_cross_reference: NDFRT:N0000006516
database_cross_reference: RCD:x01RI
database_cross_reference: RXNORM:7414
database_cross_reference: SNM:E-7711
database_cross_reference: SNMI:C-81640
database_cross_reference: SNOMEDCT_US:350628002
database_cross_reference: SNOMEDCT_US:419062009
database_cross_reference: SNOMEDCT_US:85335008

Pheniramine
type: Class
subclass of: Pyridines
MCID: MC00010014
PMOID: PMO:00018339
Subclass_of: Pyridines
Synonym: 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-
Synonym: Allergy Eye Drops
Synonym: Antitussive Decong Antihistamine Syr
Synonym: Bronchodex D Cap
Synonym: Bronchodex Pediatrique
Synonym: Bronchosirum Pour Enfants
Synonym: CVS Pharmacy Cold and Sore Throat Lemon Flavor
Synonym: Caldomine Dh Adulte
Synonym: Caldomine Dh Enfant
Synonym: Calmylin Ace
Tree Number: T6.3.5.20.18
database_cross_reference: AOD:0000020786
database_cross_reference: ATC:D04AA16
database_cross_reference: ATC:R06AB05
database_cross_reference: CHV:0000009597
database_cross_reference: DRUGBANK:DB01620
database_cross_reference: LNC:LP16246-8
database_cross_reference: LNC:MTHU007547
database_cross_reference: MMSL:d03086
database_cross_reference: MSH:D010632
database_cross_reference: MTHSPL:134FM9ZZ6M
database_cross_reference: NCI:C61889
database_cross_reference: NCI_FDA:134FM9ZZ6M
database_cross_reference: NDDF:004794
database_cross_reference: NDFRT:N0000005886
database_cross_reference: NDFRT:N0000147973
database_cross_reference: RCD:x01E6
database_cross_reference: RXNORM:8132
database_cross_reference: SNM:E-8859
database_cross_reference: SNMI:C-51670
database_cross_reference: SNOMEDCT_US:373500002
database_cross_reference: SNOMEDCT_US:49953001
database_cross_reference: VANDF:4019888

Picolines
type: Class
subclass of: Pyridines
MCID: MC00010205
PMOID: PMO:00018343
Subclass_of: Pyridines
Synonym: Picoline
Synonym: Picoline Compound
Synonym: Picolines [Chemical/Ingredient]
Tree Number: T6.3.5.20.19
database_cross_reference: MSH:D010847
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C746
database_cross_reference: NCI_DTP:NSC0003409
database_cross_reference: NDFRT:N0000008278

Pyridoxal Phosphate
type: Class
subclass of: Coenzymes
MCID: MC00011001
PMOID: PMO:00018347
Subclass_of: Coenzymes
Synonym: 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehyde
Synonym: 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate
Synonym: 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-
Synonym: 5 phosphate pyridoxal
Synonym: Biosechs
Synonym: Codecarboxylase
Synonym: Himitan
Synonym: PLP
Synonym: PYRIDOXAL 5'-PHOSPHATE
Synonym: PYRIDOXAL 5-PHOSPHATE
Tree Number: T6.7.1.9
database_cross_reference: AOD:0000020791
database_cross_reference: ATC:A11HA06
database_cross_reference: CHV:0000010455
database_cross_reference: CSP:3147-5307
database_cross_reference: DRUGBANK:DB00114
database_cross_reference: LNC:LP28587-1
database_cross_reference: LNC:MTHU014340
database_cross_reference: MEDCIN:199134
database_cross_reference: MMSL:227241
database_cross_reference: MMSL:30462
database_cross_reference: MSH:D011732
database_cross_reference: MTH:U002209
database_cross_reference: MTHSPL:F06SGE49M6
database_cross_reference: NCI:C81627
database_cross_reference: NCI_FDA:5V5IOJ8338
database_cross_reference: NDDF:003448
database_cross_reference: NDFRT:N0000007581
database_cross_reference: NDFRT:N0000023490
database_cross_reference: RCD:X80RW
database_cross_reference: RXNORM:9004
database_cross_reference: SNM:F-16250
database_cross_reference: SNMI:F-BB350
database_cross_reference: SNOMEDCT_US:259663004
database_cross_reference: SNOMEDCT_US:40869001
database_cross_reference: SNOMEDCT_US:424360008
database_cross_reference: VANDF:4024929

Pyridinium Compounds
type: Class
subclass of: Pyridines
MCID: MC00010993
PMOID: PMO:00018350
Subclass_of: Pyridines
Synonym: Compounds, Pyridinium
Synonym: PYRIDINIUM CPDS
Synonym: Pyridinium Compounds [Chemical/Ingredient]
Synonym: Pyridinium compounds
Synonym: pyridinium compounds
Tree Number: T6.3.5.20.22
database_cross_reference: AOD:0000020796
database_cross_reference: LCH:U003970
database_cross_reference: LCH_NW:sh85109335
database_cross_reference: MSH:D011726
database_cross_reference: NDFRT:N0000007571

Desmosine
type: Class
subclass of: PMO:00021266
MCID: MC00003748
PMOID: PMO:00018352
Subclass_of: Amino Acids, Cyclic
Synonym: 4-(4-Amino-4-Carboxybutyl)-1-(5-Amino-5-Carboxypentyl)-3,5-bis(3-Amino-3-Carboxypropyl)pyridinium
Synonym: 4-[(4S)-4-Amino-4-Carboxybutyl]-1-[(5S)-5-Amino-5-Carboxypentyl]-3,5-Bis[(3S)-3-Amino-3-Carboxypropyl]Pyridinium
Synonym: 6-{4-[(4S)-4-Amino-4-Carboxybutyl]-3,5-Bis[(3S)-3-Amino-3-Carboxypropyl]-1-Pyridiniumyl}-L-Norleucine
Synonym: DESMOSINE
Synonym: Des
Synonym: Desmosine [Chemical/Ingredient]
Synonym: Pyridinium, 4-(4-Amino-4-Carboxybutyl)-1-(5-Amino-5-Carboxypentyl)-3,5-Bis(3-Amino-3-Carboxypropyl)-
Synonym: Pyridinium, 4-(4-amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)-
Tree Number: T6.10.1.4.2
database_cross_reference: MSH:D003895
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124071
database_cross_reference: NCI_FDA:4MOL2J0TLY
database_cross_reference: NDFRT:N0000170261

Isodesmosine
type: Class
subclass of: PMO:00021266
MCID: MC00007076
PMOID: PMO:00018354
Subclass_of: Amino Acids, Cyclic
Synonym: Isodesmosine [Chemical/Ingredient]
Synonym: Pyridinium, 2-(4-amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)-
Tree Number: T6.10.1.4.5
database_cross_reference: MSH:D007524
database_cross_reference: NDFRT:N0000170260

Pyrithiamine
type: Class
subclass of: Pyrimidines
MCID: MC00011016
PMOID: PMO:00018357
Subclass_of: Pyrimidines
Synonym: 1, Heterovitamin B
Synonym: B 1, Heterovitamin
Synonym: HETEROVITAMIN B 01
Synonym: Heterovitamin B 1
Synonym: Neopyrithiamine
Synonym: Pyridinium, 1-((4-amino-2-methyl-5-pyrimidinyl)methyl)-3-(2-hydroxyethyl)-2-methyl-, bromide, monohydrobromide
Synonym: Pyrithiamine [Chemical/Ingredient]
Synonym: pyrithiamine
Tree Number: T6.3.5.21.20
database_cross_reference: AOD:0000020798
database_cross_reference: MSH:D011745
database_cross_reference: NDFRT:N0000167229

Pyridones
type: Class
subclass of: Pyridines
MCID: MC00010996
PMOID: PMO:00018361
Subclass_of: Pyridines
Synonym: Pyridinones
Synonym: Pyridone
Synonym: Pyridones [Chemical/Ingredient]
Synonym: pyridinone
Tree Number: T6.3.5.20.23
database_cross_reference: CSP:2511-1311
database_cross_reference: LCH:U003971
database_cross_reference: LCH_NW:sh85109336
database_cross_reference: MSH:D011728
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007575

Mimosine
type: Class
subclass of: PMO:00021257
MCID: MC00008320
PMOID: PMO:00018366
Subclass_of: Alanine
Synonym: (S)-2-Amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate
Synonym: 1(4H)-Pyridinepropanoic acid, alpha-amino-3-hydroxy-4-oxo-, (S)-
Synonym: L-Mimosine
Synonym: Leucaenine
Synonym: Leucaenol
Synonym: Leucenine
Synonym: Leucenol
Synonym: Mimosin
Synonym: Mimosine (substance)
Synonym: Mimosine [Chemical/Ingredient]
Tree Number: T6.10.1.1.2
database_cross_reference: DRUGBANK:DB01055
database_cross_reference: LCH:U002987
database_cross_reference: LCH_NW:sh85085461
database_cross_reference: MSH:D008898
database_cross_reference: NDFRT:N0000170223
database_cross_reference: SNMI:C-30352
database_cross_reference: SNOMEDCT_US:87931005

Pyrithioxin
type: Class
subclass of: Pyridines
MCID: MC00011017
PMOID: PMO:00018367
Subclass_of: Pyridines
Synonym: 4-Pyridinemethanol, 3,3'-(dithiobis(methylene))bis(5-hydroxy-6-methyl- )
Synonym: Dipyridoxolyldisulfide
Synonym: PYRITINOL
Synonym: Piritinol
Synonym: Pyridoxinedisulfide
Synonym: Pyrithioxin [Chemical/Ingredient]
Synonym: Pyrithioxine
Synonym: Pyritinol
Synonym: Pyritinol (substance)
Synonym: piritinol
Tree Number: T6.3.5.20.24
database_cross_reference: AOD:0000020799
database_cross_reference: AOD:0000029049
database_cross_reference: ATC:N06BX02
database_cross_reference: CHV:0000010461
database_cross_reference: DRUGBANK:DB13084
database_cross_reference: MEDCIN:198907
database_cross_reference: MSH:D011746
database_cross_reference: NCI:C74239
database_cross_reference: NCI_FDA:AK5Q5FZH2R
database_cross_reference: NDDF:006159
database_cross_reference: NDFRT:N0000167222
database_cross_reference: RXNORM:9020
database_cross_reference: SNOMEDCT_US:703591006

Quinolinic Acids
type: Class
subclass of: Pyridines
MCID: MC00011073
PMOID: PMO:00018368
Subclass_of: Pyridines
Synonym: Acids, Quinolinic
Synonym: Quinolinic Acids [Chemical/Ingredient]
Tree Number: T6.3.5.20.25
database_cross_reference: MSH:D011805
database_cross_reference: NDFRT:N0000167232

Triprolidine
type: Class
subclass of: Pyridines
MCID: MC00013132
PMOID: PMO:00018370
Subclass_of: Pyridines
Synonym: Actifed DM Syrup
Synonym: Actifed DM Tablets
Synonym: Anmin
Synonym: Coactifed
Synonym: Cotrifed
Synonym: Covan Syrup
Synonym: HISTEX PDX Drops
Synonym: M-Hist PD
Synonym: Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, (E)-
Synonym: Ratio-cotridin
Tree Number: T6.3.5.20.27
database_cross_reference: ATC:R06AX07
database_cross_reference: CHV:0000012584
database_cross_reference: DRUGBANK:DB00427
database_cross_reference: LNC:LP18102-1
database_cross_reference: LNC:MTHU003390
database_cross_reference: MEDCIN:340492
database_cross_reference: MEDCIN:40691
database_cross_reference: MMSL:10773
database_cross_reference: MMSL:d00786
database_cross_reference: MSH:D014311
database_cross_reference: MTHSPL:2L8T9S52QM
database_cross_reference: NCI:C61992
database_cross_reference: NCI_DCP:31630
database_cross_reference: NCI_FDA:2L8T9S52QM
database_cross_reference: NDDF:004799
database_cross_reference: NDFRT:N0000006903
database_cross_reference: NDFRT:N0000148049
database_cross_reference: RCD:x01EA
database_cross_reference: RXNORM:10849
database_cross_reference: SNM:E-8868
database_cross_reference: SNMI:C-51690
database_cross_reference: SNOMEDCT_US:25995007
database_cross_reference: SNOMEDCT_US:372678008
database_cross_reference: VANDF:4019964

Tropicamide
type: Class
subclass of: Pyridines
MCID: MC00013154
PMOID: PMO:00018371
Subclass_of: Pyridines
Synonym: Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-
Synonym: Bistropamide
Synonym: N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
Synonym: N-Ethyl-N-(4-pyridylmethyl)tropamide
Synonym: N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide
Synonym: TROPICAMIDE
Synonym: Tropicamid
Synonym: Tropicamida
Synonym: Tropicamide (product)
Synonym: Tropicamide (substance)
Tree Number: T6.3.5.20.28
database_cross_reference: ATC:S01FA06
database_cross_reference: CHV:0000012598
database_cross_reference: DRUGBANK:DB00809
database_cross_reference: MEDCIN:79101
database_cross_reference: MMSL:3084
database_cross_reference: MMSL:5645
database_cross_reference: MSH:D014331
database_cross_reference: MTHSPL:N0A3Z5XTC6
database_cross_reference: NCI:C47776
database_cross_reference: NCI_FDA:N0A3Z5XTC6
database_cross_reference: NDDF:001726
database_cross_reference: NDFRT:N0000006959
database_cross_reference: NDFRT:N0000146908
database_cross_reference: RCD:k77..
database_cross_reference: RXNORM:10869
database_cross_reference: SNM:E-7597
database_cross_reference: SNMI:C-97580
database_cross_reference: SNOMEDCT_US:387526001
database_cross_reference: SNOMEDCT_US:9190005
database_cross_reference: VANDF:4018592

2,2'-Dipyridyl
type: Class
subclass of: Pyridines
MCID: MC00000028
PMOID: PMO:00018372
Subclass_of: Pyridines
Synonym: 2,2 Bipyridine
Synonym: 2,2 Bipyridyl
Synonym: 2,2 Dipyridyl
Synonym: 2,2' Bipyridine
Synonym: 2,2' Dipyridyl
Synonym: 2,2'-Bipyridine
Synonym: 2,2'-Dipyridyl [Chemical/Ingredient]
Synonym: 2,2-Bipyridine
Synonym: 2,2-Bipyridyl
Synonym: 2,2-Dipyridyl
Tree Number: T6.3.5.20.29
database_cross_reference: MSH:D015082
database_cross_reference: NDFRT:N0000167243

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
type: Class
subclass of: Pyridines
MCID: MC00000007
PMOID: PMO:00018373
Subclass_of: Pyridines
Synonym: 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)
Synonym: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [Chemical/Ingredient]
Synonym: METHYLPHENYLTETRAHYDROPYRIDINE 01 04 01 02 03 06
Synonym: MPTP
Synonym: Methylphenyltetrahydropyridine
Synonym: Methylphenyltetrahydropyridine (substance)
Synonym: N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Synonym: Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-
Synonym: methylphenyltetrahydropyridine
Synonym: mptp
Tree Number: T6.3.5.20.30
database_cross_reference: CHV:0000000501
database_cross_reference: CSP:2511-0411
database_cross_reference: LCH_NW:sh86002892
database_cross_reference: MSH:D015632
database_cross_reference: NDFRT:N0000167234
database_cross_reference: PSY:31213
database_cross_reference: PSY:32433
database_cross_reference: RCD:Xa36F
database_cross_reference: SNOMEDCT_US:285407008

Indinavir
type: Class
subclass of: Pyridines
MCID: MC00133393
PMOID: PMO:00018374
Subclass_of: Pyridines
Synonym: (1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-Pentonamide
Synonym: (1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide
Synonym: Compound J
Synonym: IDV
Synonym: INDINAVIR
Synonym: Indinavir (product)
Synonym: Indinavir (substance)
Synonym: Indinavir [Chemical/Ingredient]
Synonym: indinavir
Tree Number: T6.3.5.20.31
database_cross_reference: ATC:J05AE02
database_cross_reference: CHV:0000031851
database_cross_reference: CSP:4009-0058
database_cross_reference: DRUGBANK:DB00224
database_cross_reference: LNC:LP21311-3
database_cross_reference: LNC:MTHU013846
database_cross_reference: MMSL:4875
database_cross_reference: MMSL:d03985
database_cross_reference: MSH:D019469
database_cross_reference: MTHSPL:5W6YA9PKKH
database_cross_reference: NCI:C66877
database_cross_reference: NCI_FDA:5W6YA9PKKH
database_cross_reference: NCI_NCI-GLOSS:CDR0000045520
database_cross_reference: NDDF:005733
database_cross_reference: NDFRT:N0000005722
database_cross_reference: NDFRT:N0000022031
database_cross_reference: PDQ:CDR0000042594
database_cross_reference: RCD:eiH..
database_cross_reference: RXNORM:114289
database_cross_reference: SNOMEDCT_US:108695003
database_cross_reference: SNOMEDCT_US:372529006
database_cross_reference: USPMG:MTHU000678
database_cross_reference: VANDF:4024026

Nevirapine
type: Class
subclass of: Pyridines
MCID: MC00053597
PMOID: PMO:00018375
Subclass_of: Pyridines
Synonym: 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one
Synonym: 6H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-
Synonym: Apo-nevirapine
Synonym: Apo-nevirapine XR
Synonym: Apo-zidovudine-lamivudine-nevirapine
Synonym: Auro-nevirapine
Synonym: Mylan-nevirapine
Synonym: NEV
Synonym: NEVIRAPINE
Synonym: NVP
Tree Number: T6.3.5.20.32
database_cross_reference: ATC:J05AG01
database_cross_reference: CHV:0000016392
database_cross_reference: CSP:4007-0088
database_cross_reference: DRUGBANK:DB00238
database_cross_reference: LCH_NW:sh2010013984
database_cross_reference: LNC:LP21317-0
database_cross_reference: LNC:MTHU013861
database_cross_reference: MEDCIN:75157
database_cross_reference: MMSL:175112
database_cross_reference: MMSL:5168
database_cross_reference: MMSL:d04029
database_cross_reference: MSH:D019829
database_cross_reference: MTHSPL:99DK7FVK1H
database_cross_reference: NCI:C29277
database_cross_reference: NCI_FDA:99DK7FVK1H
database_cross_reference: NDDF:006062
database_cross_reference: NDFRT:N0000005849
database_cross_reference: NDFRT:N0000148461
database_cross_reference: RCD:eiK..
database_cross_reference: RXNORM:53654
database_cross_reference: SNOMEDCT_US:108704001
database_cross_reference: SNOMEDCT_US:386898005
database_cross_reference: USPMG:MTHU000656
database_cross_reference: VANDF:4020991

Pyrimidines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00011012
PMOID: PMO:00018376
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: PYRIMIDINE
Synonym: Pyrimidine
Synonym: Pyrimidine (substance)
Synonym: Pyrimidine, NOS
Synonym: Pyrimidines [Chemical/Ingredient]
Synonym: pyrimidine
Synonym: pyrimidines
Tree Number: T6.3.5.21
database_cross_reference: AOD:0000001926
database_cross_reference: CHV:0000010460
database_cross_reference: CSP:2517-4993
database_cross_reference: FMA:82773
database_cross_reference: LCH:U003973
database_cross_reference: LCH_NW:sh85109338
database_cross_reference: MSH:D011743
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C789
database_cross_reference: NCI_FDA:K8CXK5Q32L
database_cross_reference: NDFRT:N0000007587
database_cross_reference: SNMI:F-65510
database_cross_reference: SNOMEDCT_US:7321000

Dipyridamole
type: Class
subclass of: Pyrimidines
MCID: MC00004025
PMOID: PMO:00018377
Subclass_of: Pyrimidines
Synonym: 2,2',2'',2''''-[(4,8-Dipiperidinopyrimido-[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
Synonym: Agilease
Synonym: Apo-dipyridamole-FC Tab 25mg
Synonym: Apo-dipyridamole-FC Tab 50mg
Synonym: Apo-dipyridamole-FC Tab 75mg
Synonym: Apo-dipyridamole-SC Tab 25mg
Synonym: Apo-dipyridamole-SC Tab 50mg
Synonym: Apo-dipyridamole-SC Tab 75mg
Synonym: Asasantine Cap
Synonym: Aspirin and Extended - Release Dipyridamole Capsules, 25 mg / 200 mg
Tree Number: T6.3.5.21.7
database_cross_reference: ATC:B01AC07
database_cross_reference: CHV:0000003995
database_cross_reference: CSP:0873-8944
database_cross_reference: DRUGBANK:DB00975
database_cross_reference: LNC:LP14715-4
database_cross_reference: LNC:LP208668-6
database_cross_reference: LNC:LP35684-7
database_cross_reference: LNC:MTHU001809
database_cross_reference: MEDCIN:40536
database_cross_reference: MMSL:2527
database_cross_reference: MMSL:4619
database_cross_reference: MMSL:d00213
database_cross_reference: MSH:D004176
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:64ALC7F90C
database_cross_reference: NCI:C445
database_cross_reference: NCI_DCP:07908
database_cross_reference: NCI_FDA:64ALC7F90C
database_cross_reference: NCI_NCI-GLOSS:CDR0000045193
database_cross_reference: NDDF:000691
database_cross_reference: NDFRT:N0000006853
database_cross_reference: NDFRT:N0000146237
database_cross_reference: PDQ:CDR0000039229
database_cross_reference: RCD:bu1..
database_cross_reference: RXNORM:3521
database_cross_reference: SNM:E-7698
database_cross_reference: SNMI:C-81590
database_cross_reference: SNOMEDCT_US:387371005
database_cross_reference: SNOMEDCT_US:66859009
database_cross_reference: USPMG:MTHU000886
database_cross_reference: VANDF:4017884

Hexetidine
type: Class
subclass of: Pyrimidines
MCID: MC00006241
PMOID: PMO:00018378
Subclass_of: Pyrimidines
Synonym: 5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-
Synonym: Actigrip Gola
Synonym: Belosept
Synonym: HEXETIDINE
Synonym: Hexetidine (product)
Synonym: Hexetidine (substance)
Synonym: Hexetidine [Chemical/Ingredient]
Synonym: Hexétidine
Synonym: Isozid-H
Synonym: Steri/sol Liquid
Tree Number: T6.3.5.21.9
database_cross_reference: ATC:A01AB12
database_cross_reference: ATC:G01AX16
database_cross_reference: DRUGBANK:DB08958
database_cross_reference: MSH:D006590
database_cross_reference: NCI:C77049
database_cross_reference: NCI_FDA:852A84Y8LS
database_cross_reference: NDDF:003906
database_cross_reference: NDFRT:N0000167195
database_cross_reference: RCD:le3..
database_cross_reference: RXNORM:5301
database_cross_reference: SNM:E-7115
database_cross_reference: SNMI:C-90289
database_cross_reference: SNOMEDCT_US:2497003
database_cross_reference: SNOMEDCT_US:387132001

Mopidamol
type: Class
subclass of: Pyrimidines
MCID: MC00008406
PMOID: PMO:00018379
Subclass_of: Pyrimidines
Synonym: 2,2',2",2"'-[(4-Piperidinopyrimido[5,4-d-]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
Synonym: 2,2',2",2"'-[[4-(1-Piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol
Synonym: 2,6-Bis(diethanolamino)-4-piperidino-pyrimido[5,4-d]pyrimidine
Synonym: Ethanol, 2,2',2'',2'''-((4-(1-piperidinyl)pyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-
Synonym: MOPIDAMOL
Synonym: Mopidamol [Chemical/Ingredient]
Synonym: mopidamol
Tree Number: T6.3.5.21.11
database_cross_reference: MSH:D009012
database_cross_reference: NCI:C668
database_cross_reference: NCI_FDA:4Q0IWP8B8O
database_cross_reference: NDFRT:N0000167189
database_cross_reference: PDQ:CDR0000040652

Pyrimethamine
type: Class
subclass of: Pyrimidines
MCID: MC00011007
PMOID: PMO:00018380
Subclass_of: Pyrimidines
Synonym: 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine
Synonym: 2,4-Diamino-5-(P-chlorophenyl)-6-ethylpyrimidine
Synonym: 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine
Synonym: 2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-
Synonym: 5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine
Synonym: 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine
Synonym: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Synonym: CD
Synonym: PYRIMETHAMINE
Synonym: Pirimetamina
Tree Number: T6.3.5.21.16
database_cross_reference: AOD:0000020801
database_cross_reference: ATC:P01BD01
database_cross_reference: CHV:0000010458
database_cross_reference: CSP:2515-2517
database_cross_reference: DRUGBANK:DB00205
database_cross_reference: LNC:LP32679-0
database_cross_reference: LNC:MTHU016256
database_cross_reference: MEDCIN:40391
database_cross_reference: MMSL:5396
database_cross_reference: MMSL:72370
database_cross_reference: MMSL:d00364
database_cross_reference: MSH:D011739
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:Z3614QOX8W
database_cross_reference: NCI:C788
database_cross_reference: NCI_DTP:NSC0003061
database_cross_reference: NCI_FDA:Z3614QOX8W
database_cross_reference: NDDF:002948
database_cross_reference: NDFRT:N0000006064
database_cross_reference: NDFRT:N0000146163
database_cross_reference: PDQ:CDR0000039578
database_cross_reference: RCD:ej6..
database_cross_reference: RXNORM:9010
database_cross_reference: SNM:E-7385
database_cross_reference: SNMI:C-56540
database_cross_reference: SNOMEDCT_US:373769001
database_cross_reference: SNOMEDCT_US:59589008
database_cross_reference: USPMG:MTHU000560
database_cross_reference: VANDF:4017802

Pyrimidine Nucleosides
type: Class
subclass of: Pyrimidines
subclass of: PMO:00020982
MCID: MC00011010
PMOID: PMO:00018381
Subclass_of: Nucleosides
Subclass_of: Pyrimidines
Synonym: Nucleosides, Pyrimidine
Synonym: Pyrimidine Nucleosides [Chemical/Ingredient]
Synonym: Pyrimidine nucleoside
Synonym: Pyrimidine nucleoside (substance)
Synonym: pyrimidine nucleoside
Synonym: pyrimidine nucleosides
Tree Number: T6.11.3.4
Tree Number: T6.3.5.21.17
database_cross_reference: AOD:0000020656
database_cross_reference: CSP:2516-7501
database_cross_reference: MSH:D011741
database_cross_reference: NDFRT:N0000008147
database_cross_reference: RCD:Xa9pn
database_cross_reference: SNOMEDCT_US:304079009

Cytidine
type: Class
subclass of: Pyrimidine Nucleosides
subclass of: PMO:00024070
MCID: MC00003479
PMOID: PMO:00018382
Subclass_of: Pyrimidine Nucleosides
Subclass_of: Ribonucleosides
Synonym: CYTIDINE
Synonym: Cytidine (substance)
Synonym: Cytidine [Chemical/Ingredient]
Synonym: Cytosine Ribonucleoside
Synonym: Cytosine Riboside
Synonym: Ribonucleoside, Cytosine
Synonym: Riboside, Cytosine
Synonym: cytidine
Synonym: cytidines
Synonym: cytodine
Tree Number: T6.11.3.4.1
Tree Number: T6.11.3.5.2
database_cross_reference: AOD:0000020657
database_cross_reference: CHV:0000003566
database_cross_reference: CSP:2516-7735
database_cross_reference: DRUGBANK:DB02097
database_cross_reference: LNC:LP201693-1
database_cross_reference: LNC:MTHU051175
database_cross_reference: MSH:D003562
database_cross_reference: NCI:C409
database_cross_reference: NCI_FDA:5CSZ8459RP
database_cross_reference: NDDF:005771
database_cross_reference: NDFRT:N0000007916
database_cross_reference: SNM:F-15410
database_cross_reference: SNMI:F-65610
database_cross_reference: SNOMEDCT_US:75265007

Cytarabine
type: Class
subclass of: PMO:00024067
MCID: MC00003478
PMOID: PMO:00018383
Subclass_of: Arabinonucleosides
Synonym: .beta.-Cytosine arabinoside
Synonym: 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
Synonym: 1-.beta.-D-Arabinofuranosylcytosine
Synonym: 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone
Synonym: 1-Beta-D-arabinofuranosylcytosine
Synonym: 1-beta-D-Arabinofuranosylcytosine
Synonym: 1.beta.-D-Arabinofuranosylcytosine
Synonym: 2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl-
Synonym: 2(1H)-Pyrimidinone, 4-amino-1-beta-D-arabinofuranosyl-
Synonym: 2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-
Tree Number: T6.11.3.1.2
database_cross_reference: ATC:L01BC01
database_cross_reference: CHV:0000003565
database_cross_reference: CSP:2516-7794
database_cross_reference: DRUGBANK:DB00987
database_cross_reference: LNC:LP70367-5
database_cross_reference: MEDCIN:40501
database_cross_reference: MEDCIN:40502
database_cross_reference: MMSL:372
database_cross_reference: MMSL:4526
database_cross_reference: MMSL:d00201
database_cross_reference: MSH:D003561
database_cross_reference: MTHSPL:04079A1RDZ
database_cross_reference: NCI:C408
database_cross_reference: NCI_DCP:01949
database_cross_reference: NCI_DTP:NSC0287459
database_cross_reference: NCI_FDA:04079A1RDZ
database_cross_reference: NCI_NCI-GLOSS:CDR0000045155
database_cross_reference: NDDF:002649
database_cross_reference: NDFRT:N0000006080
database_cross_reference: NDFRT:N0000146419
database_cross_reference: PDQ:CDR0000039015
database_cross_reference: RCD:h31..
database_cross_reference: RXNORM:3041
database_cross_reference: SNM:E-8348
database_cross_reference: SNMI:C-78080
database_cross_reference: SNOMEDCT_US:387511003
database_cross_reference: SNOMEDCT_US:89265009
database_cross_reference: VANDF:4018080

Deoxycytidine
type: Class
subclass of: PMO:00024068
MCID: MC00003674
PMOID: PMO:00018385
Subclass_of: Deoxyribonucleosides
Synonym: 1-(2-deoxy-.beta.-d-ribofuranosyl)cytosine
Synonym: 2'-Deoxycytidine
Synonym: 4-amino-1-(2-deoxy-.beta.-d-erythro-pentofuranosyl)-2(1h)-pyrimidinone
Synonym: Cytidine, 2'-deoxy-
Synonym: Cytosine Deoxyribonucleoside
Synonym: Cytosine Deoxyriboside
Synonym: Deoxycytidine [Chemical/Ingredient]
Synonym: Deoxyribonucleoside, Cytosine
Synonym: Deoxyribose cytidine
Synonym: Deoxyriboside, Cytosine
Tree Number: T6.11.3.2.2
database_cross_reference: CHV:0000003766
database_cross_reference: CSP:2516-7852
database_cross_reference: DRUGBANK:DB02594
database_cross_reference: MSH:D003841
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C420
database_cross_reference: NCI_NCI-GLOSS:CDR0000045496
database_cross_reference: NDFRT:N0000007762
database_cross_reference: PDQ:CDR0000042500

Formycins
type: Class
subclass of: Pyrimidine Nucleosides
subclass of: PMO:00024070
MCID: MC00005276
PMOID: PMO:00018391
Subclass_of: Pyrimidine Nucleosides
Subclass_of: Ribonucleosides
Synonym: Formycin
Synonym: Formycins [Chemical/Ingredient]
Synonym: formycin
Tree Number: T6.11.3.4.2
Tree Number: T6.11.3.5.4
database_cross_reference: CSP:2109-1853
database_cross_reference: DRUGBANK:DB02281
database_cross_reference: MSH:D005573
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008152

Pentostatin
type: Class
subclass of: PMO:00024068
MCID: MC00009846
PMOID: PMO:00018393
Subclass_of: Deoxyribonucleosides
Synonym: (R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Synonym: (R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Synonym: 2' Deoxycoformycin
Synonym: 2'-Deoxycoformycin
Synonym: 2'-deoxycoformycin
Synonym: DCF
Synonym: DEOXYCOFORMYCIN 02
Synonym: Deoxycoformycin
Synonym: Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
Synonym: PENTOSTATIN
Tree Number: T6.11.3.2.7
database_cross_reference: ATC:L01XX08
database_cross_reference: CHV:0000009446
database_cross_reference: CSP:0197-3300
database_cross_reference: DRUGBANK:DB00552
database_cross_reference: MEDCIN:48459
database_cross_reference: MMSL:118563
database_cross_reference: MMSL:5256
database_cross_reference: MMSL:d01356
database_cross_reference: MSH:D015649
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:395575MZO7
database_cross_reference: NCI:C732
database_cross_reference: NCI_DTP:NSC0247520
database_cross_reference: NCI_FDA:395575MZO7
database_cross_reference: NCI_NCI-GLOSS:CDR0000045190
database_cross_reference: NDDF:003617
database_cross_reference: NDFRT:N0000007243
database_cross_reference: NDFRT:N0000148177
database_cross_reference: PDQ:CDR0000039210
database_cross_reference: RCD:h5A..
database_cross_reference: RXNORM:8011
database_cross_reference: SNMI:C-B9060
database_cross_reference: SNOMEDCT_US:28149003
database_cross_reference: SNOMEDCT_US:387154004
database_cross_reference: VANDF:4020329

Thymidine
type: Class
subclass of: Pyrimidine Nucleosides
subclass of: PMO:00024068
MCID: MC00012800
PMOID: PMO:00018394
Subclass_of: Deoxyribonucleosides
Subclass_of: Pyrimidine Nucleosides
Synonym: TDR
Synonym: THYMIDINE
Synonym: Thymidin
Synonym: Thymidine (substance)
Synonym: Thymidine [Chemical/Ingredient]
Synonym: dT
Synonym: thymidin
Synonym: thymidine
Tree Number: T6.11.3.2.5
Tree Number: T6.11.3.4.3
database_cross_reference: AOD:0000018541
database_cross_reference: CHV:0000012237
database_cross_reference: CSP:2516-8437
database_cross_reference: DRUGBANK:DB04485
database_cross_reference: LCH:U004677
database_cross_reference: LCH_NW:sh85135140
database_cross_reference: LNC:LP62257-8
database_cross_reference: LNC:MTHU025438
database_cross_reference: MSH:D013936
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:VC2W18DGKR
database_cross_reference: NCI:C880
database_cross_reference: NCI_DCP:00606
database_cross_reference: NCI_DTP:NSC0021548
database_cross_reference: NCI_FDA:VC2W18DGKR
database_cross_reference: NCI_NCI-GLOSS:CDR0000045241
database_cross_reference: NDDF:005774
database_cross_reference: NDFRT:N0000007616
database_cross_reference: PDQ:CDR0000039715
database_cross_reference: RXNORM:1372538
database_cross_reference: SNM:F-15570
database_cross_reference: SNMI:F-65770
database_cross_reference: SNOMEDCT_US:3892007

Tunicamycin
type: Class
subclass of: Pyrimidine Nucleosides
MCID: MC00013237
PMOID: PMO:00018398
Subclass_of: Pyrimidine Nucleosides
Synonym: Tunicamycin [Chemical/Ingredient]
Synonym: tunicamycin
Tree Number: T6.11.3.4.4
database_cross_reference: CHV:0000012663
database_cross_reference: CSP:0210-2200
database_cross_reference: DRUGBANK:DB13172
database_cross_reference: LCH:U004817
database_cross_reference: LCH_NW:sh85138639
database_cross_reference: MSH:D014415
database_cross_reference: NDFRT:N0000170634

Uridine
type: Class
subclass of: Pyrimidine Nucleosides
subclass of: PMO:00024070
MCID: MC00013360
PMOID: PMO:00018399
Subclass_of: Pyrimidine Nucleosides
Subclass_of: Ribonucleosides
Synonym: UR
Synonym: URIDINE
Synonym: Urd
Synonym: Uridine (product)
Synonym: Uridine (substance)
Synonym: Uridine [Chemical/Ingredient]
Synonym: uridine
Tree Number: T6.11.3.4.5
Tree Number: T6.11.3.5.11
database_cross_reference: AOD:0000020658
database_cross_reference: CHV:0000012775
database_cross_reference: CSP:2516-9256
database_cross_reference: DRUGBANK:DB02745
database_cross_reference: LCH:U004861
database_cross_reference: LCH_NW:sh85141399
database_cross_reference: LNC:LP99932-3
database_cross_reference: LNC:MTHU047919
database_cross_reference: MMSL:d05935
database_cross_reference: MSH:D014529
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:WHI7HQ7H85
database_cross_reference: NCI:C922
database_cross_reference: NCI_FDA:WHI7HQ7H85
database_cross_reference: NDDF:005776
database_cross_reference: NDFRT:N0000008252
database_cross_reference: NDFRT:N0000192396
database_cross_reference: PDQ:CDR0000040800
database_cross_reference: RXNORM:11017
database_cross_reference: SNM:F-15620
database_cross_reference: SNMI:F-65820
database_cross_reference: SNOMEDCT_US:57763003
database_cross_reference: SNOMEDCT_US:715619008
database_cross_reference: VANDF:4035398

Arabinofuranosyluracil
type: Class
subclass of: PMO:00024067
MCID: MC00001200
PMOID: PMO:00018400
Subclass_of: Arabinonucleosides
Synonym: 1 beta D Arabinofuranosyl Uracil
Synonym: 1-beta-D-Arabinofuranosyl Uracil
Synonym: 2,4(1H,3H)-Pyrimidinedione, 1-beta-D-arabinofuranosyl-
Synonym: Ara U
Synonym: Ara-U
Synonym: Arabinofuranoside, Uracil
Synonym: Arabinofuranosyluracil [Chemical/Ingredient]
Synonym: Arabinoside, Uracil
Synonym: Arabinosyluracil
Synonym: Arauridine
Tree Number: T6.11.3.1.1
database_cross_reference: MSH:D001086
database_cross_reference: NDFRT:N0000170632

Deoxyuridine
type: Class
subclass of: PMO:00024068
MCID: MC00003699
PMOID: PMO:00018401
Subclass_of: Deoxyribonucleosides
Synonym: (beta 1-(2-Deoxyribopyranosyl))thymidine
Synonym: 1-(2-Deoxy-Beta-D-Erythro-Pentofuranosyl)Uracil
Synonym: 1-(2-Deoxy-Beta-D-Erythro-Pentofuranoxyl)Uracil
Synonym: 2'-Deoxyuridine
Synonym: 2'-Desoxyuridine
Synonym: 2,4(1H,3H)-Pyrimidinedione, 1-(2-Deoxy-Beta-D-Erythro-Ribofuranosyl)-
Synonym: 2,4(1H,3H)-Pyrimidinedione, 1-(2-Deoxy-Beta-D-Ribofuranosyl)-
Synonym: 2-Deoxyuridine
Synonym: Deoxyribose Uracil
Synonym: Deoxyuridine (substance)
Tree Number: T6.11.3.2.4
database_cross_reference: CHV:0000003772
database_cross_reference: CSP:2516-8905
database_cross_reference: DRUGBANK:DB02256
database_cross_reference: LNC:LP61824-6
database_cross_reference: LNC:MTHU025316
database_cross_reference: MSH:D003857
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C120006
database_cross_reference: NDFRT:N0000007770
database_cross_reference: RCD:X80UX
database_cross_reference: SNOMEDCT_US:259700005

Pyrimidine Nucleotides
type: Class
subclass of: Pyrimidines
subclass of: PMO:00020983
MCID: MC00011011
PMOID: PMO:00018408
Subclass_of: Nucleotides
Subclass_of: Pyrimidines
Synonym: Nucleotides, Pyrimidine
Synonym: Pyrimidine Nucleotides [Chemical/Ingredient]
Synonym: Pyrimidine nucleotide
Synonym: Pyrimidine nucleotide (substance)
Synonym: Pyrimidine nucleotides
Synonym: pyrimidine nucleotide
Synonym: pyrimidine nucleotides
Tree Number: T6.11.4.6
Tree Number: T6.3.5.21.18
database_cross_reference: AOD:0000020684
database_cross_reference: CSP:2516-9374
database_cross_reference: LCH:U003972
database_cross_reference: LCH_NW:sh85109337
database_cross_reference: MSH:D011742
database_cross_reference: NDFRT:N0000170767
database_cross_reference: RCD:X80M6
database_cross_reference: SNOMEDCT_US:259526002

Apurinic Acid
type: Class
subclass of: Pyrimidine Nucleotides
MCID: MC00001190
PMOID: PMO:00018409
Subclass_of: Pyrimidine Nucleotides
Synonym: Acid, Apurinic
Synonym: Apurinic Acid [Chemical/Ingredient]
Synonym: Apurinic acid
Tree Number: T6.11.4.6.1
database_cross_reference: MSH:D001080
database_cross_reference: NDFRT:N0000170802

Cytosine Nucleotides
type: Class
subclass of: Pyrimidine Nucleotides
subclass of: PMO:00024098
MCID: MC00003521
PMOID: PMO:00018410
Subclass_of: Pyrimidine Nucleotides
Subclass_of: Ribonucleotides
Synonym: Cytidine Phosphates
Synonym: Cytosine Nucleotides [Chemical/Ingredient]
Synonym: Nucleotides, Cytosine
Synonym: Phosphates, Cytidine
Synonym: cytosine nucleotide
Tree Number: T6.11.4.6.2
Tree Number: T6.11.4.7.2
database_cross_reference: CSP:2516-9472
database_cross_reference: MSH:D003597
database_cross_reference: NDFRT:N0000170769

Arabinofuranosylcytosine Triphosphate
type: Class
subclass of: PMO:00024075
MCID: MC00001199
PMOID: PMO:00018411
Subclass_of: Arabinonucleotides
Synonym: 2(1H)-Pyrimidinone, 4-amino-1-(5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-arabinofuranosyl)-
Synonym: Ara CTP
Synonym: Ara-CTP
Synonym: AraCTP
Synonym: Arabinofuranosylcytosine Triphosphate [Chemical/Ingredient]
Synonym: Arabinosylcytosine 5'-Triphosphate
Synonym: Arabinosylcytosine Triphosphate
Synonym: Cytarabine Triphosphate
Synonym: Cytosine Arabinoside Triphosphate
Synonym: Triphosphate, Arabinofuranosylcytosine
Tree Number: T6.11.4.1.2
database_cross_reference: MSH:D001085
database_cross_reference: NCI:C105950
database_cross_reference: NDFRT:N0000170788

Cyclic CMP
type: Class
subclass of: PMO:00024077
MCID: MC00003480
PMOID: PMO:00018412
Subclass_of: Nucleotides, Cyclic
Synonym: CMP, Cyclic
Synonym: CYCL CMP
Synonym: CYTIDINE CYCLIC MONOPHOSPHATE 03 05
Synonym: Cyclic CMP [Chemical/Ingredient]
Synonym: Cyclic Monophosphate, Cytidine
Synonym: Cyclic-3',5'-Monophosphate, Cytidine
Synonym: Cytidine Cyclic 3',5' Monophosphate
Synonym: Cytidine Cyclic 3,5 Monophosphate
Synonym: Cytidine Cyclic Monophosphate
Synonym: Cytidine Cyclic-3',5'-Monophosphate
Tree Number: T6.11.4.3.2
database_cross_reference: MSH:D003563
database_cross_reference: NDFRT:N0000170790

Deoxycytosine Nucleotides
type: Class
subclass of: PMO:00024076
MCID: MC00003678
PMOID: PMO:00018417
Subclass_of: Deoxyribonucleotides
Synonym: Deoxycytidine Phosphates
Synonym: Deoxycytosine Nucleotides [Chemical/Ingredient]
Synonym: Nucleotides, Deoxycytosine
Synonym: Phosphates, Deoxycytidine
Tree Number: T6.11.4.2.2
database_cross_reference: MSH:D003845
database_cross_reference: NDFRT:N0000170855

Pyrimidine Dimers
type: Class
subclass of: Pyrimidine Nucleotides
MCID: MC00011009
PMOID: PMO:00018419
Subclass_of: Pyrimidine Nucleotides
Synonym: Cyclobutane Pyrimidine Dimer
Synonym: Cyclobutane Pyrimidine Dimers
Synonym: Cyclobutane-Pyrimidine Dimers
Synonym: Dimers, Cyclobutane-Pyrimidine
Synonym: Dimers, Pyrimidine
Synonym: Pyrimidine Dimer
Synonym: Pyrimidine Dimers [Chemical/Ingredient]
Synonym: pyrimidine dimer
Tree Number: T6.11.4.6.3
database_cross_reference: AOD:0000020686
database_cross_reference: CSP:2102-8744
database_cross_reference: MSH:D011740
database_cross_reference: NCI:C2171
database_cross_reference: NCI:C790
database_cross_reference: NDFRT:N0000170805

Thymine Nucleotides
type: Class
subclass of: Pyrimidine Nucleotides
subclass of: PMO:00024076
MCID: MC00012806
PMOID: PMO:00018420
Subclass_of: Deoxyribonucleotides
Subclass_of: Pyrimidine Nucleotides
Synonym: Nucleotides, Thymine
Synonym: Phosphates, Thymidine
Synonym: Thymidine Phosphates
Synonym: Thymidine phosphate
Synonym: Thymine Nucleotides [Chemical/Ingredient]
Synonym: thymine nucleotide
Tree Number: T6.11.4.2.6
Tree Number: T6.11.4.6.4
database_cross_reference: AOD:0000020688
database_cross_reference: DRUGBANK:DB01643
database_cross_reference: MSH:D013942
database_cross_reference: NDFRT:N0000170862

Uracil Nucleotides
type: Class
subclass of: Pyrimidine Nucleotides
subclass of: PMO:00024098
MCID: MC00013334
PMOID: PMO:00018422
Subclass_of: Pyrimidine Nucleotides
Subclass_of: Ribonucleotides
Synonym: Nucleotides, Uracil
Synonym: Nucleotides, Uridine
Synonym: Phosphates, Uridine
Synonym: Uracil Nucleotides [Chemical/Ingredient]
Synonym: Uridine Nucleotides
Synonym: Uridine Phosphates
Synonym: Uridine phosphate
Synonym: Uridine phosphate (substance)
Synonym: uracil nucleotide
Synonym: uracil nucleotides
Tree Number: T6.11.4.6.5
Tree Number: T6.11.4.7.8
database_cross_reference: AOD:0000020691
database_cross_reference: CSP:2517-0452
database_cross_reference: DRUGBANK:DB03685
database_cross_reference: MSH:D014500
database_cross_reference: NDFRT:N0000170776
database_cross_reference: RCD:Xa9q8
database_cross_reference: SNOMEDCT_US:304098006

Deoxyuracil Nucleotides
type: Class
subclass of: PMO:00024076
MCID: MC00003698
PMOID: PMO:00018423
Subclass_of: Deoxyribonucleotides
Synonym: Deoxyuracil Nucleotides [Chemical/Ingredient]
Synonym: Deoxyuridine Phosphates
Synonym: Nucleotides, Deoxyuracil
Synonym: Phosphates, Deoxyuridine
Tree Number: T6.11.4.2.4
database_cross_reference: MSH:D003856
database_cross_reference: NDFRT:N0000170860

Pyrimidinones
type: Class
subclass of: Pyrimidines
MCID: MC00011013
PMOID: PMO:00018437
Subclass_of: Pyrimidines
Synonym: Pyrimidinones [Chemical/Ingredient]
Synonym: pyrimidinone
Tree Number: T6.3.5.21.19
database_cross_reference: AOD:0000020802
database_cross_reference: MSH:D011744
database_cross_reference: NDFRT:N0000007588

Trimethoprim
type: Class
subclass of: Pyrimidines
MCID: MC00013113
PMOID: PMO:00018469
Subclass_of: Pyrimidines
Synonym: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
Synonym: 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-
Synonym: 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
Synonym: Alprim
Synonym: Apo Sulfatrim DS Tab
Synonym: Apo Sulfatrim Pediatric
Synonym: Apo Sulfatrim Tab
Synonym: Apo-sulfatrim Oral Suspension
Synonym: Bactrim DS Roche Tab
Synonym: Bactrim Roche Inj
Tree Number: T6.3.5.21.23
database_cross_reference: ATC:J01EA01
database_cross_reference: CHV:0000012573
database_cross_reference: CSP:2517-6492
database_cross_reference: DRUGBANK:DB00440
database_cross_reference: LCH:U004784
database_cross_reference: LCH_NW:sh85137542
database_cross_reference: LNC:LP15010-9
database_cross_reference: LNC:MTHU002305
database_cross_reference: MEDCIN:40341
database_cross_reference: MMSL:3055
database_cross_reference: MMSL:5633
database_cross_reference: MMSL:d00123
database_cross_reference: MSH:D014295
database_cross_reference: MTH:U002327
database_cross_reference: MTHSPL:AN164J8Y0X
database_cross_reference: NCI:C908
database_cross_reference: NCI_DTP:NSC0106568
database_cross_reference: NCI_FDA:AN164J8Y0X
database_cross_reference: NDDF:002873
database_cross_reference: NDFRT:N0000006193
database_cross_reference: NDFRT:N0000146103
database_cross_reference: PDQ:CDR0000040847
database_cross_reference: RCD:ecc..
database_cross_reference: RXNORM:10829
database_cross_reference: SNM:E-7199
database_cross_reference: SNMI:C-55630
database_cross_reference: SNOMEDCT_US:32792001
database_cross_reference: SNOMEDCT_US:387179001
database_cross_reference: USPMG:MTHU000217
database_cross_reference: VANDF:4017735

Pyrrolidines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00011031
PMOID: PMO:00018470
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Pyrrolidines [Chemical/Ingredient]
Tree Number: T6.3.5.22
database_cross_reference: MSH:D011759
database_cross_reference: NDFRT:N0000007593

Anisomycin
type: Class
subclass of: Pyrrolidines
MCID: MC00000950
PMOID: PMO:00018471
Subclass_of: Pyrrolidines
Synonym: (-)-Anisomycin
Synonym: (2R,3S,4S)-2-(P-Methoxybenzyl)-3,4-Pyrrolidinediol 3-Acetate
Synonym: (2R,3S,4S)-2-(P-Methoxyphenylmethyl)-3-Acetoxy-4-Hydroxypyrrolidine
Synonym: 3,4-Pyrrolidinediol, 2-((4-methoxyphenyl)methyl)-, 3-acetate, (2R-(2alpha,3alpha,4beta))-
Synonym: ANISOMYCIN
Synonym: Anisomycin [Chemical/Ingredient]
Tree Number: T6.3.5.22.1
database_cross_reference: DRUGBANK:DB07374
database_cross_reference: MSH:D000841
database_cross_reference: NCI:C95312
database_cross_reference: NCI_FDA:6C74YM2NGI
database_cross_reference: NDFRT:N0000167149

Clemastine
type: Class
subclass of: Pyrrolidines
MCID: MC00002949
PMOID: PMO:00018472
Subclass_of: Pyrrolidines
Synonym: (+)-(2R)-2-(2-(((R)-P-chloro-alpha-Methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine
Synonym: (+)-(2R)-2-(2-(((R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine
Synonym: (+)-(2R)-2-(2-(((R)-p-chloro-α-methyl-α-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine
Synonym: (+)-(2R)-2-[2-[[(R)-P-chloro-alpha-Methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine
Synonym: (+)-(2R)-2-[2-[[(R)-p-chloro-α-methyl-α-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine
Synonym: 2-(2-(1-(4-Chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine
Synonym: CLEMASTINE
Synonym: Clemastina
Synonym: Clemastine (product)
Synonym: Clemastine (substance)
Tree Number: T6.3.5.22.2
database_cross_reference: ATC:D04AA14
database_cross_reference: ATC:R06AA04
database_cross_reference: CHV:0000003029
database_cross_reference: DRUGBANK:DB00283
database_cross_reference: MMSL:d00780
database_cross_reference: MSH:D002974
database_cross_reference: MTHSPL:95QN29S1ID
database_cross_reference: NCI:C61682
database_cross_reference: NCI_FDA:95QN29S1ID
database_cross_reference: NDDF:004441
database_cross_reference: NDFRT:N0000007134
database_cross_reference: NDFRT:N0000147773
database_cross_reference: RCD:c85..
database_cross_reference: RXNORM:2578
database_cross_reference: SNMI:C-51440
database_cross_reference: SNOMEDCT_US:372744005
database_cross_reference: SNOMEDCT_US:45218006
database_cross_reference: USPMG:MTHU001627
database_cross_reference: VANDF:4019681

Kainic Acid
type: Class
subclass of: Pyrrolidines
MCID: MC00007165
PMOID: PMO:00018473
Subclass_of: Pyrrolidines
Synonym: 2-Carboxy-4-isopropenyl-3-pyrrolidineacetic Acid
Synonym: 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2alpha,3beta,4beta))-
Synonym: Acid, Digenic
Synonym: Acid, Kainic
Synonym: Digenic Acid
Synonym: KAINIC ACID
Synonym: Kainic Acid [Chemical/Ingredient]
Synonym: Kainic acid
Synonym: L-alpha-Kainic Acid
Synonym: acid kainic
Tree Number: T6.3.5.22.4
database_cross_reference: AOD:0000029060
database_cross_reference: CHV:0000007034
database_cross_reference: LCH:U002557
database_cross_reference: LCH_NW:sh85071296
database_cross_reference: MSH:D007608
database_cross_reference: NCI:C79132
database_cross_reference: NCI_FDA:SIV03811UC
database_cross_reference: NDDF:006209
database_cross_reference: NDFRT:N0000167151
database_cross_reference: PSY:27305

Nafoxidine
type: Class
subclass of: Pyrrolidines
MCID: MC00008635
PMOID: PMO:00018474
Subclass_of: Pyrrolidines
Synonym: NAFOXIDINE
Synonym: NFX
Synonym: Nafoxidine (product)
Synonym: Nafoxidine (substance)
Synonym: Nafoxidine [Chemical/Ingredient]
Synonym: Pyrrolidine, 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)-
Tree Number: T6.3.5.22.6
database_cross_reference: MSH:D009256
database_cross_reference: NCI:C677
database_cross_reference: NCI_FDA:4RIY10WM82
database_cross_reference: NDFRT:N0000167156
database_cross_reference: SNM:E-8384
database_cross_reference: SNMI:C-78310
database_cross_reference: SNOMEDCT_US:20201001
database_cross_reference: SNOMEDCT_US:373472009

Nitromifene
type: Class
subclass of: Pyrrolidines
MCID: MC00008947
PMOID: PMO:00018475
Subclass_of: Pyrrolidines
Synonym: NITROMIFENE
Synonym: Nitromifene [Chemical/Ingredient]
Synonym: Nitromiphene
Synonym: Pyrrolidine, 1-(2-(4-(1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl)phenoxy)ethyl)-
Tree Number: T6.3.5.22.7
database_cross_reference: MSH:D009594
database_cross_reference: NCI:C90720
database_cross_reference: NCI_FDA:5FS1NJ6Q8N
database_cross_reference: NDFRT:N0000167150

Pentolinium Tartrate
type: Class
subclass of: Pyrrolidines
MCID: MC00009840
PMOID: PMO:00018476
Subclass_of: Pyrrolidines
Synonym: PENTOLINIUM TARTRATE
Synonym: Pentolinium Tartrate [Chemical/Ingredient]
Synonym: Pentolonium Tartrate
Synonym: Pyrrolidinium, 1,1'-(1,5-pentanediyl)bis(1-methyl)-, salt with (R-(R*,R*))-2,3-dihydroxybutanedioic acid (1:2)
Synonym: Tartrate, Pentolinium
Synonym: Tartrate, Pentolonium
Synonym: pentolinium tartrate
Synonym: pentolinium tartrate (discontinued)
Synonym: pentolinium tartrate (discontinued) (medication)
Tree Number: T6.3.5.22.8
database_cross_reference: MEDCIN:257653
database_cross_reference: MSH:D010425
database_cross_reference: NCI:C66345
database_cross_reference: NCI_FDA:953357GACY
database_cross_reference: NDDF:000634
database_cross_reference: NDFRT:N0000167148

Procyclidine
type: Class
subclass of: Pyrrolidines
MCID: MC00010657
PMOID: PMO:00018477
Subclass_of: Pyrrolidines
Synonym: 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol
Synonym: 1-Pyrrolidinepropanol, alpha-cyclohexyl-alpha-phenyl-
Synonym: 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride
Synonym: Extranil
Synonym: Kdrine
Synonym: Kemadrin Elx
Synonym: Kemadrin Tab 5mg
Synonym: PHL-procyclidine Tablets
Synonym: PROCYCLIDINE
Synonym: Pdp-procyclidine
Tree Number: T6.3.5.22.9
database_cross_reference: ATC:N04AA04
database_cross_reference: CHV:0000010148
database_cross_reference: DRUGBANK:DB00387
database_cross_reference: LNC:LP17867-0
database_cross_reference: LNC:MTHU003219
database_cross_reference: MMSL:d00969
database_cross_reference: MSH:D011352
database_cross_reference: NCI:C73270
database_cross_reference: NCI_FDA:C6QE1Q1TKR
database_cross_reference: NDDF:004666
database_cross_reference: NDFRT:N0000005858
database_cross_reference: NDFRT:N0000147992
database_cross_reference: RCD:x01Dj
database_cross_reference: RXNORM:8718
database_cross_reference: SNM:E-7587
database_cross_reference: SNMI:C-67540
database_cross_reference: SNOMEDCT_US:387247001
database_cross_reference: SNOMEDCT_US:44990002
database_cross_reference: VANDF:4019907

Pyrrolidinones
type: Class
subclass of: Pyrrolidines
MCID: MC00011032
PMOID: PMO:00018478
Subclass_of: Pyrrolidines
Synonym: Pyrrolidinones [Chemical/Ingredient]
Synonym: Pyrrolidones
Synonym: pyrrolidinone
Synonym: pyrrolidone
Synonym: pyrrolidones
Tree Number: T6.3.5.22.10
database_cross_reference: AOD:0000020841
database_cross_reference: CHV:0000010467
database_cross_reference: CSP:2521-9945
database_cross_reference: MSH:D011760
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007594

Tenuazonic Acid
type: Class
subclass of: PMO:00024389
MCID: MC00012611
PMOID: PMO:00018484
Subclass_of: Mycotoxins
Synonym: 2H-Pyrrol-2-one, 3-acetyl-1,5-dihydro-4-hydroxy-5-(1-methylpropyl)-, (S-(R*,R*))-
Synonym: Acid, Tenuazonic
Synonym: Tenuazonic Acid [Chemical/Ingredient]
Synonym: Tenuazonic acid
Synonym: [S-(R*,R*)]-3-Acetyl-1,5-dihydro-4-hydroxy-5-(1-methylpropyl)-2H-pyrrol-2-one
Tree Number: T6.13.8.6.14
database_cross_reference: MSH:D013720
database_cross_reference: NCI:C858
database_cross_reference: NCI_DCP:00642
database_cross_reference: NCI_DTP:NSC0638261
database_cross_reference: NDFRT:N0000171425

Tremorine
type: Class
subclass of: Pyrrolidines
MCID: MC00013031
PMOID: PMO:00018486
Subclass_of: Pyrrolidines
Synonym: Pyrrolidine, 1,1'-(2-butyne-1,4-diyl)bis-
Synonym: Tremorine [Chemical/Ingredient]
Synonym: tremorine
Tree Number: T6.3.5.22.11
database_cross_reference: AOD:0000020839
database_cross_reference: CSP:2059-1199
database_cross_reference: MSH:D014203
database_cross_reference: NDFRT:N0000167158

Bepridil
type: Class
subclass of: Pyrrolidines
MCID: MC00001617
PMOID: PMO:00018487
Subclass_of: Pyrrolidines
Synonym: 1-(2-(N-Benzylanilino)-1-(Isobutoxymethyl)Ethyl)-Pyrrolidine
Synonym: 1-Pyrrolideneethanamine, Beta-((2-Methylpropoxy)Methyl)-N-Phenyl-N-(Phenylmethyl)-
Synonym: 1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-
Synonym: Angopril
Synonym: BEPRIDIL
Synonym: Bepridil (product)
Synonym: Bepridil (substance)
Synonym: Bepridil [Chemical/Ingredient]
Synonym: bepridil
Synonym: bepridil (medication)
Tree Number: T6.3.5.22.12
database_cross_reference: ATC:C08EA02
database_cross_reference: CHV:0000001806
database_cross_reference: DRUGBANK:DB01244
database_cross_reference: MEDCIN:340351
database_cross_reference: MMSL:d00688
database_cross_reference: MSH:D015764
database_cross_reference: NCI:C87448
database_cross_reference: NCI_FDA:755BO701MA
database_cross_reference: NDDF:004519
database_cross_reference: NDFRT:N0000006461
database_cross_reference: NDFRT:N0000147724
database_cross_reference: RXNORM:1436
database_cross_reference: SNOMEDCT_US:108530004
database_cross_reference: SNOMEDCT_US:372503006
database_cross_reference: VANDF:4019631

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
type: Class
subclass of: Pyrrolidines
MCID: MC00334472
PMOID: PMO:00018488
Subclass_of: Pyrrolidines
Synonym: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer [Chemical/Ingredient]
Synonym: Benzeneacetamide, 3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-, (trans)-Isomer
Synonym: DICHLOROMETHYLPYRROLIDINYLCYCLOHEXYL BENZENEACETAMIDE 003 004 N N 002 001
Synonym: trans-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
Tree Number: T6.3.5.22.13
database_cross_reference: MSH:D019900
database_cross_reference: NDFRT:N0000167147

Lincosamides
type: Class
subclass of: Pyrrolidines
subclass of: PMO:00020950
MCID: MC00030323
PMOID: PMO:00018489
Subclass_of: Glycosides
Subclass_of: Pyrrolidines
Synonym: Lincosamide
Synonym: Lincosamide (product)
Synonym: Lincosamides [Chemical/Ingredient]
Synonym: lincosamide
Synonym: lincosamides
Tree Number: T6.3.5.22.15
Tree Number: T6.8.6.19
database_cross_reference: ATC:J01FF
database_cross_reference: CHV:0000014291
database_cross_reference: MSH:D055231
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000175442
database_cross_reference: SNOMEDCT_US:423967005

Lincomycin
type: Class
subclass of: Lincosamides
MCID: MC00007572
PMOID: PMO:00018490
Subclass_of: Lincosamides
Synonym: D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-
Synonym: LCM
Synonym: LINCOMYCIN
Synonym: Lincobect
Synonym: Lincolnensin
Synonym: Lincomycin (product)
Synonym: Lincomycin (substance)
Synonym: Lincomycin A
Synonym: Lincomycin [Chemical/Ingredient]
Synonym: Lincomycine
Tree Number: T6.8.6.19.1
database_cross_reference: ATC:J01FF02
database_cross_reference: CHV:0000007430
database_cross_reference: CSP:0189-5476
database_cross_reference: DRUGBANK:DB01627
database_cross_reference: LCH:U002702
database_cross_reference: LCH_NW:sh85077140
database_cross_reference: LNC:LP15879-7
database_cross_reference: LNC:MTHU008097
database_cross_reference: MEDCIN:340432
database_cross_reference: MMSL:4979
database_cross_reference: MMSL:7112
database_cross_reference: MMSL:d00279
database_cross_reference: MSH:D008034
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:BOD072YW0F
database_cross_reference: NCI:C61811
database_cross_reference: NCI_FDA:BOD072YW0F
database_cross_reference: NDDF:004867
database_cross_reference: NDFRT:N0000006123
database_cross_reference: NDFRT:N0000147891
database_cross_reference: RCD:ea2..
database_cross_reference: RXNORM:6398
database_cross_reference: SNM:E-7208
database_cross_reference: SNMI:C-52250
database_cross_reference: SNOMEDCT_US:2596005
database_cross_reference: SNOMEDCT_US:372677003
database_cross_reference: USPMG:MTHU000226
database_cross_reference: VANDF:4019802

Triazines
type: Class
subclass of: Heterocyclic Compounds, 1-Ring
MCID: MC00013048
PMOID: PMO:00018492
Subclass_of: Heterocyclic Compounds, 1-Ring
Synonym: Triazines [Chemical/Ingredient]
Synonym: triazine
Synonym: triazines
Tree Number: T6.3.5.26
database_cross_reference: CHV:0000012520
database_cross_reference: CSP:2980-1303
database_cross_reference: LCH:U004767
database_cross_reference: LCH_NW:sh85137416
database_cross_reference: MSH:D014227
database_cross_reference: NDFRT:N0000007561

Apazone
type: Class
subclass of: Triazines
MCID: MC00001149
PMOID: PMO:00018493
Subclass_of: Triazines
Synonym: 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-
Synonym: 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione
Synonym: APAZONE
Synonym: Apazone (product)
Synonym: Apazone [Chemical/Ingredient]
Synonym: Apazone product
Synonym: Apazone product (substance)
Synonym: Azapropazone
Synonym: Azapropazone (product)
Synonym: Azapropazone (substance)
Tree Number: T6.3.5.26.1
database_cross_reference: ATC:M01AX04
database_cross_reference: CHV:0000001366
database_cross_reference: DRUGBANK:DB07402
database_cross_reference: LCH:U005170
database_cross_reference: LCH_NW:sh85010628
database_cross_reference: MSH:D001032
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C73074
database_cross_reference: NCI_FDA:K2VOT966ZI
database_cross_reference: NDDF:003712
database_cross_reference: NDFRT:N0000167162
database_cross_reference: RCD:j21..
database_cross_reference: RXNORM:1029
database_cross_reference: SNOMEDCT_US:329543000
database_cross_reference: SNOMEDCT_US:363590006
database_cross_reference: SNOMEDCT_US:391798003

Atrazine
type: Class
subclass of: Triazines
MCID: MC00001359
PMOID: PMO:00018494
Subclass_of: Triazines
Synonym: 1,3,5-Triazine-2,4-diamine, 6-chloro-N-ethyl-N'-(1-methylethyl)-
Synonym: Atrazine (substance)
Synonym: Atrazine [Chemical/Ingredient]
Synonym: atrazine
Tree Number: T6.3.5.26.2
database_cross_reference: CHV:0000001569
database_cross_reference: LCH:U000423
database_cross_reference: LCH_NW:sh85009352
database_cross_reference: MSH:D001280
database_cross_reference: NDFRT:N0000167165
database_cross_reference: RCD:X807t
database_cross_reference: SNMI:C-23551
database_cross_reference: SNOMEDCT_US:85612002

Altretamine
type: Class
subclass of: Triazines
MCID: MC00006236
PMOID: PMO:00018495
Subclass_of: Triazines
Synonym: 1,3,5-Triazine-2,4,6-triamine, N,N,N',N',N'',N''-hexamethyl-
Synonym: 2,4,6-Tris(dimethylamino)-1,3,5-triazine
Synonym: 2,4,6-Tris(dimethylamino)-S-triazine
Synonym: 2,4,6-Tris(dimethylamino)-s-triazine
Synonym: 2,4,6-tris(dimethylamino)-s-triazine
Synonym: ALTRETAMINE
Synonym: Altretamin
Synonym: Altretamina
Synonym: Altretamine (product)
Synonym: Altretamine (substance)
Tree Number: T6.3.5.26.4
database_cross_reference: ATC:L01XX03
database_cross_reference: CHV:0000006121
database_cross_reference: CSP:2980-1303
database_cross_reference: DRUGBANK:DB00488
database_cross_reference: MEDCIN:48461
database_cross_reference: MMSL:4156
database_cross_reference: MMSL:d01372
database_cross_reference: MSH:D006585
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:Q8BIH59O7H
database_cross_reference: NCI:C544
database_cross_reference: NCI_DTP:NSC0013875
database_cross_reference: NCI_FDA:Q8BIH59O7H
database_cross_reference: NCI_NCI-GLOSS:CDR0000045215
database_cross_reference: NDDF:003567
database_cross_reference: NDFRT:N0000007266
database_cross_reference: NDFRT:N0000147673
database_cross_reference: PDQ:CDR0000039475
database_cross_reference: RCD:h5H..
database_cross_reference: RXNORM:5296
database_cross_reference: SNM:E-8377
database_cross_reference: SNMI:C-78285
database_cross_reference: SNOMEDCT_US:387385000
database_cross_reference: SNOMEDCT_US:391745001
database_cross_reference: SNOMEDCT_US:69879000
database_cross_reference: USPMG:MTHU000465
database_cross_reference: VANDF:4019574

Oxonic Acid
type: Class
subclass of: Triazines
MCID: MC00009573
PMOID: PMO:00018496
Subclass_of: Triazines
Synonym: 1,3,5-Triazine-2-carboxylic acid, 1,4,5,6-tetrahydro-4,6-dioxo-
Synonym: 5-azaorotic acid
Synonym: Allantoxanic acid
Synonym: OTERACIL
Synonym: Oteracil
Synonym: Oteracil (substance)
Synonym: Oxonic Acid [Chemical/Ingredient]
Synonym: Oxonic acid
Synonym: oteracil
Tree Number: T6.3.5.26.5
database_cross_reference: DRUGBANK:DB03209
database_cross_reference: MSH:D010094
database_cross_reference: NCI:C76917
database_cross_reference: NCI_FDA:5VT6420TIG
database_cross_reference: NDDF:015260
database_cross_reference: NDFRT:N0000167159
database_cross_reference: SNOMEDCT_US:708825002

Prometryne
type: Class
subclass of: Triazines
MCID: MC00010692
PMOID: PMO:00018497
Subclass_of: Triazines
Synonym: 1,3,5-Triazine-2,4-diamine, N,N'-bis(1-methylethyl)-6-(methylthio)-
Synonym: Prometryn
Synonym: Prometryne [Chemical/Ingredient]
Tree Number: T6.3.5.26.6
database_cross_reference: MSH:D011400
database_cross_reference: NDFRT:N0000167163

Simazine
type: Class
subclass of: Triazines
MCID: MC00011880
PMOID: PMO:00018498
Subclass_of: Triazines
Synonym: 1,3,5-Triazine-2,4-diamine, 6-chloro-N,N'-diethyl-
Synonym: Simazine (substance)
Synonym: Simazine [Chemical/Ingredient]
Tree Number: T6.3.5.26.7
database_cross_reference: LNC:LP34419-9
database_cross_reference: LNC:MTHU017393
database_cross_reference: MSH:D012839
database_cross_reference: NDFRT:N0000167164
database_cross_reference: RCD:X808L
database_cross_reference: SNOMEDCT_US:259117009

Heterocyclic Oxides
type: Class
subclass of: Heterocyclic Compounds
MCID: MC00006230
PMOID: PMO:00018499
Subclass_of: Heterocyclic Compounds
Synonym: Heterocyclic Oxides [Chemical/Ingredient]
Synonym: Oxides, Heterocyclic
Tree Number: T6.3.6
database_cross_reference: MSH:D006577
database_cross_reference: NDFRT:N0000167035

Cyclic N-Oxides
type: Class
subclass of: Heterocyclic Oxides
MCID: MC00003399
PMOID: PMO:00018500
Subclass_of: Heterocyclic Oxides
Synonym: CYCLIC OXIDES N
Synonym: Cyclic N Oxides
Synonym: Cyclic N-Oxides [Chemical/Ingredient]
Synonym: HETEROCYCLIC OXIDES N
Synonym: Heterocyclic N Oxides
Synonym: Heterocyclic N-Oxides
Synonym: N Oxides, Cyclic
Synonym: N-Oxides, Cyclic
Synonym: N-Oxides, Heterocyclic
Synonym: Oxides, Cyclic N
Tree Number: T6.3.6.1
database_cross_reference: MSH:D003497
database_cross_reference: NDFRT:N0000167038

Cyclic P-Oxides
type: Class
subclass of: Heterocyclic Oxides
MCID: MC00003400
PMOID: PMO:00018501
Subclass_of: Heterocyclic Oxides
Synonym: CYCLIC OXIDES P
Synonym: Cyclic P Oxides
Synonym: Cyclic P-Oxides [Chemical/Ingredient]
Synonym: HETEROCYCLIC OXIDES P
Synonym: Heterocyclic P Oxides
Synonym: Heterocyclic P-Oxides
Synonym: Oxides, Cyclic P
Synonym: P Oxides, Cyclic
Synonym: P-Oxides, Cyclic
Synonym: P-Oxides, Heterocyclic
Tree Number: T6.3.6.2
database_cross_reference: MSH:D003498
database_cross_reference: NDFRT:N0000167036

Polycyclic Compounds
type: Class
subclass of: Chemical and Drug
MCID: MC00010404
PMOID: PMO:00018502
Subclass_of: Chemical and Drug
Synonym: Compounds, Polycyclic
Synonym: POLYCYCLIC CPDS
Synonym: Polycyclic Compounds [Chemical/Ingredient]
Synonym: Polycyclic compound
Synonym: Polycyclic compound (substance)
Synonym: Polycyclic compounds
Synonym: polycyclic compounds
Tree Number: T6.4
database_cross_reference: AOD:0000019781
database_cross_reference: LCH:U003752
database_cross_reference: LCH_NW:sh85104607
database_cross_reference: MSH:D011083
database_cross_reference: NDFRT:N0000011331
database_cross_reference: SNOMEDCT_US:417174002

Fused-Ring Compounds
type: Class
subclass of: Polycyclic Compounds
MCID: MC01054882
PMOID: PMO:00018503
Subclass_of: Polycyclic Compounds
Synonym: Fused Ring Compounds
Synonym: Fused-Ring Compounds [Chemical/Ingredient]
Tree Number: T6.4.1
database_cross_reference: MSH:D000072473
database_cross_reference: NDFRT:N0000193169

Steroids
type: Class
subclass of: Fused-Ring Compounds
MCID: MC00012231
PMOID: PMO:00018504
Subclass_of: Fused-Ring Compounds
Synonym: Steroid
Synonym: Steroid (substance)
Synonym: Steroid Compound
Synonym: Steroid, NOS
Synonym: Steroids [Chemical/Ingredient]
Synonym: steroid
Synonym: steroids
Tree Number: T6.4.1.1
database_cross_reference: AOD:0000000870
database_cross_reference: CHV:0000011730
database_cross_reference: CSP:2793-9541
database_cross_reference: LCH:U004477
database_cross_reference: LCH_NW:sh85128057
database_cross_reference: LNC:LA15260-5
database_cross_reference: LNC:LP20784-2
database_cross_reference: MEDLINEPLUS:4557
database_cross_reference: MSH:D013256
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C843
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046601
database_cross_reference: NDFRT:N0000007720
database_cross_reference: PSY:49830
database_cross_reference: SNMI:F-B0200
database_cross_reference: SNOMEDCT_US:112113009
database_cross_reference: SNOMEDCT_US:116566001

Androstanes
type: Class
subclass of: Steroids
MCID: MC00000870
PMOID: PMO:00018505
Subclass_of: Steroids
Synonym: Androstane
Synonym: Androstane (substance)
Synonym: Androstanes [Chemical/Ingredient]
Synonym: androstane
Synonym: androstane compound
Synonym: androstanes
Tree Number: T6.4.1.1.1
database_cross_reference: AOD:0000021003
database_cross_reference: CHV:0000001111
database_cross_reference: CSP:0170-5244
database_cross_reference: MSH:D000731
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008241
database_cross_reference: SNOMEDCT_US:126087002

Bile Acids and Salts
type: Class
subclass of: Steroids
MCID: MC00001713
PMOID: PMO:00018541
Subclass_of: Steroids
Synonym: BILE ACIDS SALTS
Synonym: Bile Acids and Salts [Chemical/Ingredient]
Synonym: bile acids and salts
Tree Number: T6.4.1.1.2
database_cross_reference: AOD:0000019264
database_cross_reference: MSH:D001647
database_cross_reference: NDFRT:N0000006801

Cardanolides
type: Class
subclass of: Steroids
MCID: MC00002303
PMOID: PMO:00018554
Subclass_of: Steroids
Synonym: Cardanolides [Chemical/Ingredient]
Synonym: cardanolides
Tree Number: T6.4.1.1.3
database_cross_reference: AOD:0000021039
database_cross_reference: MSH:D002297
database_cross_reference: NDFRT:N0000008140

Cardiac Glycosides
type: Class
subclass of: PMO:00020950
MCID: MC00002305
PMOID: PMO:00018555
Subclass_of: Glycosides
Synonym: CARDIAC GLYCOSIDES
Synonym: Cardiac Glycosides [Chemical/Ingredient]
Synonym: Cardiac glycoside
Synonym: Cardiac glycoside, NOS
Synonym: Cardiac glycosides
Synonym: Cardiotonic Steroids
Synonym: Glycoside
Synonym: Glycoside (product)
Synonym: Glycoside (substance)
Synonym: Glycoside, NOS
Tree Number: T6.8.6.4
database_cross_reference: AOD:0000019845
database_cross_reference: ATC:C01A
database_cross_reference: CHV:0000002441
database_cross_reference: CSP:0567-0162
database_cross_reference: LCH:U000799
database_cross_reference: LCH_NW:sh85020182
database_cross_reference: LNC:LP31498-6
database_cross_reference: MEDCIN:40590
database_cross_reference: MSH:D002301
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C66894
database_cross_reference: NDFRT:N0000008157
database_cross_reference: RCD:b1...
database_cross_reference: SNMI:C-80140
database_cross_reference: SNOMEDCT_US:33589008
database_cross_reference: SNOMEDCT_US:372707005

Proscillaridin
type: Class
subclass of: Cardiac Glycosides
MCID: MC00010735
PMOID: PMO:00018557
Subclass_of: Cardiac Glycosides
Synonym: Bufa-4,20,22-trienolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-14-hydroxy-, (3beta)-
Synonym: Desglucotransvaaline
Synonym: PROSCILLARIDIN
Synonym: Proscillaridin A
Synonym: Proscillaridin [Chemical/Ingredient]
Synonym: Proscillaridine
Synonym: Rhamnoside, Scillarenin
Synonym: Scillarenin Rhamnoside
Synonym: proscillaridin
Tree Number: T6.8.6.4.2
database_cross_reference: ATC:C01AB01
database_cross_reference: DRUGBANK:DB13307
database_cross_reference: MSH:D011442
database_cross_reference: NCI:C84121
database_cross_reference: NCI_FDA:KC6BL281EN
database_cross_reference: NDDF:003759
database_cross_reference: NDFRT:N0000168447
database_cross_reference: RXNORM:8795

Digitalis Glycosides
type: Class
subclass of: Cardiac Glycosides
PMOID: PMO:00018559
Subclass_of: Cardiac Glycosides
Tree Number: T6.8.6.4.1

Strophanthins
type: Class
subclass of: Cardiac Glycosides
MCID: MC00012288
PMOID: PMO:00018570
Subclass_of: Cardiac Glycosides
Synonym: Strophanthins [Chemical/Ingredient]
Tree Number: T6.8.6.4.3
database_cross_reference: MSH:D013328
database_cross_reference: NDFRT:N0000168452

Cholanes
type: Class
subclass of: Steroids
MCID: MC00002699
PMOID: PMO:00018574
Subclass_of: Steroids
Synonym: Cholanes [Chemical/Ingredient]
Synonym: cholanes
Tree Number: T6.4.1.1.4
database_cross_reference: AOD:0000021021
database_cross_reference: MSH:D002757
database_cross_reference: NDFRT:N0000008184

Cholestanes
type: Class
subclass of: Steroids
MCID: MC00002722
PMOID: PMO:00018576
Subclass_of: Steroids
Synonym: Cholestanes [Chemical/Ingredient]
Synonym: cholestane
Synonym: cholestane compound
Synonym: cholestanes
Tree Number: T6.4.1.1.5
database_cross_reference: AOD:0000021030
database_cross_reference: CHV:0000002878
database_cross_reference: CSP:0658-0853
database_cross_reference: MSH:D002776
database_cross_reference: NDFRT:N0000008187

Cholecalciferol
type: Class
subclass of: Sterols
MCID: MC00002706
PMOID: PMO:00018581
Subclass_of: Sterols
Synonym: (+)-vitamin D3
Synonym: (1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
Synonym: (3 beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
Synonym: (3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
Synonym: (3beta,5Z,7e)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
Synonym: (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
Synonym: (5Z,7e)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
Synonym: 9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
Synonym: 9,10-Secocholesta-5,7,10(19)-trien-3-ol
Synonym: 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3beta,5Z,7E)-
Tree Number: T6.9.11.5.2
database_cross_reference: AOD:0000018254
database_cross_reference: AOD:0000028217
database_cross_reference: ATC:A11CC05
database_cross_reference: CHV:0000002862
database_cross_reference: CSP:3147-7320
database_cross_reference: DRUGBANK:DB00169
database_cross_reference: DRUGBANK:DB11094
database_cross_reference: LCH_NW:sh2004001239
database_cross_reference: LNC:LA18888-0
database_cross_reference: LNC:LP15456-4
database_cross_reference: LNC:MTHU008559
database_cross_reference: MEDCIN:41273
database_cross_reference: MEDCIN:42121
database_cross_reference: MEDLINEPLUS:5383
database_cross_reference: MMSL:15676
database_cross_reference: MMSL:199274
database_cross_reference: MMSL:4434
database_cross_reference: MMSL:4868
database_cross_reference: MMSL:4871
database_cross_reference: MMSL:d03129
database_cross_reference: MSH:D002762
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:1C6V77QF41
database_cross_reference: NCI:C48194
database_cross_reference: NCI_CRCH:C48194
database_cross_reference: NCI_DCP:00678
database_cross_reference: NCI_DTP:NSC0375571
database_cross_reference: NCI_FDA:1C6V77QF41
database_cross_reference: NCI_NCI-GLOSS:CDR0000427252
database_cross_reference: NDDF:001014
database_cross_reference: NDFRT:N0000006996
database_cross_reference: NDFRT:N0000146043
database_cross_reference: PDQ:CDR0000039734
database_cross_reference: RCD:X80RZ
database_cross_reference: RXNORM:2418
database_cross_reference: SNM:E-8767
database_cross_reference: SNM:F-16090
database_cross_reference: SNMI:C-A4860
database_cross_reference: SNMI:F-BB090
database_cross_reference: SNOMEDCT_US:108943009
database_cross_reference: SNOMEDCT_US:126236008
database_cross_reference: SNOMEDCT_US:15211009
database_cross_reference: SNOMEDCT_US:18414002
database_cross_reference: SNOMEDCT_US:418425007
database_cross_reference: VANDF:4017667

Fusidic Acid
type: Class
subclass of: Sterols
MCID: MC00005362
PMOID: PMO:00018591
Subclass_of: Sterols
Synonym: 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3alpha,4alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-
Synonym: Acid, Fusidic
Synonym: FUSIDIC ACID
Synonym: Fucidin Cream 2%
Synonym: Fucidin Film Coated Tab 250mg
Synonym: Fucidin Intertulle 2%
Synonym: Fucidin Leo Injection Kit
Synonym: Fucidin Leo Sus 246mg/5ml
Synonym: Fucidin Ointment 2%
Synonym: Fucidin acid
Tree Number: T6.9.11.5.5
database_cross_reference: ATC:D06AX01
database_cross_reference: ATC:D09AA02
database_cross_reference: ATC:J01XC01
database_cross_reference: ATC:S01AA13
database_cross_reference: CHV:0000005303
database_cross_reference: CSP:0658-0853
database_cross_reference: DRUGBANK:DB02703
database_cross_reference: MEDCIN:199319
database_cross_reference: MSH:D005672
database_cross_reference: MTHSPL:59XE10C19C
database_cross_reference: NCI:C65793
database_cross_reference: NCI_FDA:59XE10C19C
database_cross_reference: NDDF:003486
database_cross_reference: NDFRT:N0000167438
database_cross_reference: RCD:k3g..
database_cross_reference: RCD:md2..
database_cross_reference: RXNORM:4608
database_cross_reference: SNMI:C-522E0
database_cross_reference: SNOMEDCT_US:330403009
database_cross_reference: SNOMEDCT_US:387530003
database_cross_reference: SNOMEDCT_US:96015006

Stigmasterol
type: Class
subclass of: Phytosterols
MCID: MC00012239
PMOID: PMO:00018592
Subclass_of: Phytosterols
Synonym: Poriferasterol
Synonym: STIGMASTEROL
Synonym: Stigmasta-5,22-dien-3-ol, (3beta,22E)-
Synonym: Stigmasterol [Chemical/Ingredient]
Synonym: stigmasterol
Tree Number: T6.13.14.1.2
database_cross_reference: LNC:LP173719-8
database_cross_reference: LNC:MTHU047878
database_cross_reference: MSH:D013265
database_cross_reference: NCI:C68427
database_cross_reference: NCI_CRCH:C68427
database_cross_reference: NCI_FDA:99WUK5D0Y8
database_cross_reference: NDDF:012933
database_cross_reference: NDFRT:N0000167440
database_cross_reference: RXNORM:10079

Ecdysteroids
type: Class
subclass of: Phytosterols
MCID: MC00025682
PMOID: PMO:00018595
Subclass_of: Phytosterols
Synonym: Ecdysteroid
Synonym: Ecdysteroids [Chemical/Ingredient]
Synonym: ecdysteroid
Synonym: ecdysteroids
Tree Number: T6.13.14.1.3
database_cross_reference: CHV:0000013933
database_cross_reference: LCH_NW:sh90004349
database_cross_reference: MSH:D026461
database_cross_reference: NDFRT:N0000167487

Cholesterol
type: Class
subclass of: Sterols
MCID: MC00002731
PMOID: PMO:00018598
Subclass_of: Sterols
Synonym: (-)-Cholesterol
Synonym: (3beta)-Cholest-5-en-3-ol
Synonym: 5-cholesten-3B-ol
Synonym: CHOLESTEROL
Synonym: Cholest-5-en-3-ol (3beta)-
Synonym: Cholesterol (substance)
Synonym: Cholesterol [Chemical/Ingredient]
Synonym: cholesterol
Tree Number: T6.9.11.5.3
database_cross_reference: AOD:0000001902
database_cross_reference: CCPSS:0046352
database_cross_reference: CHV:0000002883
database_cross_reference: CSP:0658-4141
database_cross_reference: DRUGBANK:DB04540
database_cross_reference: LCH:U000989
database_cross_reference: LCH_NW:sh85024654
database_cross_reference: LNC:LP100019-1
database_cross_reference: LNC:LP15493-7
database_cross_reference: LNC:MTHU003147
database_cross_reference: MEDLINEPLUS:26
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D002784
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000243
database_cross_reference: MTH:U000296
database_cross_reference: MTHSPL:97C5T2UQ7J
database_cross_reference: NCI:C369
database_cross_reference: NCI_CRCH:C369
database_cross_reference: NCI_DCP:00759
database_cross_reference: NCI_DTP:NSC0008798
database_cross_reference: NCI_FDA:97C5T2UQ7J
database_cross_reference: NCI_NCI-GLOSS:CDR0000407756
database_cross_reference: NDDF:002556
database_cross_reference: NDFRT:N0000007064
database_cross_reference: NDFRT:N0000146961
database_cross_reference: PSY:09020
database_cross_reference: RCD:X80Iz
database_cross_reference: RXNORM:2438
database_cross_reference: SNM:F-13980
database_cross_reference: SNMI:F-63980
database_cross_reference: SNOMEDCT_US:84698008
database_cross_reference: VANDF:4018648

Ergocalciferols
type: Class
subclass of: Sterols
MCID: MC00004646
PMOID: PMO:00018604
Subclass_of: Sterols
Synonym: Calciferols
Synonym: Ergocalciferols [Chemical/Ingredient]
Tree Number: T6.9.11.5.4
database_cross_reference: MSH:D004872
database_cross_reference: NDFRT:N0000006337

Withanolides
type: Class
subclass of: Phytosterols
MCID: MC00628714
PMOID: PMO:00018608
Subclass_of: Phytosterols
Synonym: Withanolides [Chemical/Ingredient]
Tree Number: T6.13.14.1.4
database_cross_reference: MSH:D054358
database_cross_reference: NDFRT:N0000178762

Sitosterols
type: Class
subclass of: Phytosterols
MCID: MC00011904
PMOID: PMO:00018609
Subclass_of: Phytosterols
Synonym: SITOSTEROLS
Synonym: Sitosterols [Chemical/Ingredient]
Synonym: sitosterol
Synonym: sitosterols
Synonym: sitosterols (medication)
Tree Number: T6.13.14.1.1
database_cross_reference: CHV:0000011376
database_cross_reference: CSP:0659-0306
database_cross_reference: MEDCIN:40453
database_cross_reference: MSH:D012855
database_cross_reference: MTH:U002245
database_cross_reference: MTHSPL:G7V636VTDY
database_cross_reference: NDDF:002062
database_cross_reference: NDFRT:N0000167441
database_cross_reference: RXNORM:9808

Sterols
type: Class
subclass of: PMO:00021216
MCID: MC00012236
PMOID: PMO:00018612
Subclass_of: Membrane Lipids
Synonym: Sterol
Synonym: Sterol (substance)
Synonym: Sterol, NOS
Synonym: Sterols [Chemical/Ingredient]
Synonym: sterol
Synonym: sterols
Tree Number: T6.9.11.5
database_cross_reference: AOD:0000021034
database_cross_reference: CHV:0000011731
database_cross_reference: CSP:2795-0313
database_cross_reference: LCH:U004478
database_cross_reference: LCH_NW:sh85128059
database_cross_reference: MSH:D013261
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007730
database_cross_reference: SNM:F-13970
database_cross_reference: SNMI:F-63970
database_cross_reference: SNOMEDCT_US:16136003

Adosterol
type: Class
subclass of: Sterols
MCID: MC00000411
PMOID: PMO:00018613
Subclass_of: Sterols
Synonym: 19-Norcholest-5(10)-en-3-ol, 6-(iodomethyl)-, (3beta,6beta)-
Synonym: 6 Iodomethylnorcholesterol
Synonym: 6-Iodomethylnorcholesterol
Synonym: Adosterol [Chemical/Ingredient]
Synonym: IODOMETHYLNORCHOLESTEROL 06
Tree Number: T6.9.11.5.1
database_cross_reference: MSH:D000301
database_cross_reference: NDFRT:N0000167437

Cholesterol, Dietary
type: Class
subclass of: PMO:00021065
MCID: MC00002738
PMOID: PMO:00018614
Subclass_of: Dietary Fats
Synonym: Cholesterol, Dietary [Chemical/Ingredient]
Synonym: Dietary Cholesterol
Synonym: cholesterol dietary
Synonym: dietary cholesterol
Tree Number: T6.9.2.1.2
database_cross_reference: CHV:0000002886
database_cross_reference: MSH:D002791
database_cross_reference: NDFRT:N0000168641

Cholesterol, HDL
type: Class
subclass of: PMO:00021207
MCID: MC00007619
PMOID: PMO:00018615
Subclass_of: Lipoproteins, HDL
Synonym: CHOLESTEROL HDL
Synonym: Cholesterol, HDL [Chemical/Ingredient]
Synonym: Cholesterol, alpha-Lipoprotein
Synonym: HDL - High density lipoprotein cholesterol
Synonym: HDL Cholesterol
Synonym: HDL cholesterol
Synonym: HDL cholesterol (substance)
Synonym: HDL-High density lipoprot chol
Synonym: HDLC - High density lipoprotein cholesterol
Synonym: HDLC-Hi-densit lipoprot choles
Tree Number: T6.9.10.6.1
database_cross_reference: CCPSS:1004319
database_cross_reference: CHV:0000007472
database_cross_reference: MSH:D008076
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000272
database_cross_reference: MTH:U000277
database_cross_reference: MTH:U000281
database_cross_reference: MTH:U000286
database_cross_reference: NDFRT:N0000170093
database_cross_reference: RCD:X80NX
database_cross_reference: SNMI:F-63981
database_cross_reference: SNOMEDCT_US:102737005

Cholesterol, LDL
type: Class
subclass of: PMO:00021211
MCID: MC00007621
PMOID: PMO:00018616
Subclass_of: Lipoproteins, LDL
Synonym: CHOLESTEROL LDL
Synonym: Cholesterol, LDL [Chemical/Ingredient]
Synonym: Cholesterol, beta-Lipoprotein
Synonym: Cholesterol.in LDL
Synonym: LDL - Low density lipoprotein cholesterol
Synonym: LDL Cholesterol
Synonym: LDL Cholesterol Lipoproteins
Synonym: LDL cholesterol
Synonym: LDL cholesterol (substance)
Synonym: LDL-Low dens lipoprot cholest
Tree Number: T6.9.10.7.1
database_cross_reference: CCPSS:1004318
database_cross_reference: CHV:0000007474
database_cross_reference: LNC:LP15491-1
database_cross_reference: LNC:LP32023-1
database_cross_reference: LNC:MTHU002896
database_cross_reference: MSH:D008078
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000298
database_cross_reference: MTH:U000299
database_cross_reference: NDFRT:N0000170099
database_cross_reference: RCD:X80Ni
database_cross_reference: SNMI:F-63983
database_cross_reference: SNOMEDCT_US:102739008

Cholesterol, VLDL
type: Class
subclass of: PMO:00021212
MCID: MC00007623
PMOID: PMO:00018617
Subclass_of: Lipoproteins, VLDL
Synonym: Cholesterol, Pre-beta-Lipoprotein
Synonym: Cholesterol, Prebetalipoprotein
Synonym: Cholesterol, VLDL [Chemical/Ingredient]
Synonym: Cholesterol.in VLDL
Synonym: Pre beta Lipoprotein Cholesterol
Synonym: Pre-beta-Lipoprotein Cholesterol
Synonym: Prebetalipoprotein Cholesterol
Synonym: VLDL - Very low density lipoprotein cholesterol
Synonym: VLDL Cholesterol
Synonym: VLDL cholesterol
Tree Number: T6.9.10.8.1
database_cross_reference: CHV:0000007476
database_cross_reference: LNC:LP15492-9
database_cross_reference: LNC:MTHU004146
database_cross_reference: MSH:D015243
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170095
database_cross_reference: RCD:X80Nq
database_cross_reference: SNMI:F-63984
database_cross_reference: SNOMEDCT_US:102740005

Phytosterols
type: Class
subclass of: Sterols
subclass of: PMO:00024400
PMOID: PMO:00018618
Subclass_of: Phytochemicals
Subclass_of: Sterols
Tree Number: T6.13.14.1
Tree Number: T6.9.11.5.7

Brassinosteroids
type: Class
subclass of: Phytosterols
MCID: MC00831068
PMOID: PMO:00018619
Subclass_of: Phytosterols
Synonym: Brassinosteroids [Chemical/Ingredient]
Tree Number: T6.13.14.1.5
database_cross_reference: LCH_NW:sh91005031
database_cross_reference: MSH:D060406
database_cross_reference: NDFRT:N0000183529

Cyclosteroids
type: Class
subclass of: Steroids
MCID: MC00003435
PMOID: PMO:00018620
Subclass_of: Steroids
Synonym: Cyclosteroids [Chemical/Ingredient]
Tree Number: T6.4.1.1.6
database_cross_reference: MSH:D003525
database_cross_reference: NDFRT:N0000167470

Estranes
type: Class
subclass of: Steroids
MCID: MC00004741
PMOID: PMO:00018621
Subclass_of: Steroids
Synonym: 19 Norandrostanes
Synonym: 19-Norandrostanes
Synonym: Estrane
Synonym: Estrane (substance)
Synonym: Estranes [Chemical/Ingredient]
Synonym: NORANDROSTANES 19
Synonym: estranes
Tree Number: T6.4.1.1.7
database_cross_reference: AOD:0000021009
database_cross_reference: MSH:D004962
database_cross_reference: NDFRT:N0000008196
database_cross_reference: SNOMEDCT_US:126088007

Gonanes
type: Class
subclass of: Steroids
MCID: MC00005806
PMOID: PMO:00018635
Subclass_of: Steroids
Synonym: Gonanes [Chemical/Ingredient]
Tree Number: T6.4.1.1.8
database_cross_reference: MSH:D006067
database_cross_reference: NDFRT:N0000167464

Homosteroids
type: Class
subclass of: Steroids
MCID: MC00006383
PMOID: PMO:00018636
Subclass_of: Steroids
Synonym: Homosteroids [Chemical/Ingredient]
Tree Number: T6.4.1.1.9
database_cross_reference: MSH:D006718
database_cross_reference: NDFRT:N0000007777

Hydroxysteroids
type: Class
subclass of: Steroids
MCID: MC00006516
PMOID: PMO:00018637
Subclass_of: Steroids
Synonym: Hydroxysteroids [Chemical/Ingredient]
Synonym: hydroxysteroid
Synonym: hydroxysteroids
Tree Number: T6.4.1.1.10
database_cross_reference: CHV:0000006389
database_cross_reference: CSP:2793-9971
database_cross_reference: MSH:D006914
database_cross_reference: NDFRT:N0000167431

Ketosteroids
type: Class
subclass of: Steroids
MCID: MC00007236
PMOID: PMO:00018638
Subclass_of: Steroids
Synonym: Ketosteroids [Chemical/Ingredient]
Synonym: Oxosteroids
Synonym: ketosteroid
Synonym: ketosteroids
Tree Number: T6.4.1.1.11
database_cross_reference: CHV:0000007082
database_cross_reference: CSP:2794-1036
database_cross_reference: LNC:LP21402-0
database_cross_reference: MSH:D007664
database_cross_reference: NDFRT:N0000008266

17-Ketosteroids
type: Class
subclass of: Adrenal Cortex Hormones
MCID: MC00000021
PMOID: PMO:00018639
Subclass_of: Adrenal Cortex Hormones
Synonym: 17 Ketosteroids
Synonym: 17 Oxosteroids
Synonym: 17 ketosteroid
Synonym: 17 ketosteroids
Synonym: 17-Ketosteroid
Synonym: 17-Ketosteroid (substance)
Synonym: 17-Ketosteroids [Chemical/Ingredient]
Synonym: 17-Ketosteroids, NOS
Synonym: 17-Oxosteroid
Synonym: 17-Oxosteroid (substance)
Tree Number: T6.6.2.1.3
database_cross_reference: CHV:0000000504
database_cross_reference: LNC:LP17185-7
database_cross_reference: LNC:MTHU027217
database_cross_reference: MSH:D015068
database_cross_reference: NDFRT:N0000007748
database_cross_reference: RCD:X80Ez
database_cross_reference: SNM:F-26350
database_cross_reference: SNMI:F-B2430
database_cross_reference: SNOMEDCT_US:259335005
database_cross_reference: SNOMEDCT_US:46120009

Norsteroids
type: Class
subclass of: Steroids
MCID: MC00009013
PMOID: PMO:00018640
Subclass_of: Steroids
Synonym: Norsteroid
Synonym: Norsteroid (substance)
Synonym: Norsteroids [Chemical/Ingredient]
Synonym: norsteroid
Tree Number: T6.4.1.1.12
database_cross_reference: AOD:0000021044
database_cross_reference: CSP:2794-1414
database_cross_reference: MSH:D009654
database_cross_reference: NDFRT:N0000008275
database_cross_reference: SNOMEDCT_US:126089004

Pregnanes
type: Class
subclass of: Steroids
MCID: MC00010591
PMOID: PMO:00018664
Subclass_of: Steroids
Synonym: C21 steroid
Synonym: Pregnane
Synonym: Pregnanes (substance)
Synonym: Pregnanes [Chemical/Ingredient]
Synonym: pregnane
Synonym: pregnane compound
Synonym: pregnanes
Tree Number: T6.4.1.1.13
database_cross_reference: AOD:0000021011
database_cross_reference: CHV:0000010074
database_cross_reference: CSP:2405-1193
database_cross_reference: LCH:U003810
database_cross_reference: LCH_NW:sh85106296
database_cross_reference: MSH:D011278
database_cross_reference: NDFRT:N0000008242
database_cross_reference: SNOMEDCT_US:126090008

Secosteroids
type: Class
subclass of: Steroids
MCID: MC00011697
PMOID: PMO:00018738
Subclass_of: Steroids
Synonym: Secosteroids [Chemical/Ingredient]
Synonym: secosteroid
Synonym: secosteroids
Tree Number: T6.4.1.1.15
database_cross_reference: CHV:0000011155
database_cross_reference: MSH:D012632
database_cross_reference: NDFRT:N0000007915

Steroids, Brominated
type: Class
subclass of: Steroids
MCID: MC00012232
PMOID: PMO:00018740
Subclass_of: Steroids
Synonym: Brominated Steroids
Synonym: Steroids, Brominated [Chemical/Ingredient]
Synonym: brominated steroids
Tree Number: T6.4.1.1.16
database_cross_reference: AOD:0000020098
database_cross_reference: MSH:D013257
database_cross_reference: NDFRT:N0000167412

Steroids, Chlorinated
type: Class
subclass of: Steroids
MCID: MC00012233
PMOID: PMO:00018741
Subclass_of: Steroids
Synonym: Chlorinated Steroids
Synonym: Steroids, Chlorinated [Chemical/Ingredient]
Synonym: chlorinated steroids
Tree Number: T6.4.1.1.17
database_cross_reference: AOD:0000020101
database_cross_reference: MSH:D013258
database_cross_reference: NDFRT:N0000007723

Steroids, Fluorinated
type: Class
subclass of: Steroids
MCID: MC00012234
PMOID: PMO:00018742
Subclass_of: Steroids
Synonym: Fluorinated Steroids
Synonym: Steroids, Fluorinated [Chemical/Ingredient]
Synonym: fluorinated steroids
Tree Number: T6.4.1.1.18
database_cross_reference: AOD:0000020100
database_cross_reference: MSH:D013259
database_cross_reference: NDFRT:N0000007725

Steroids, Heterocyclic
type: Class
subclass of: Steroids
MCID: MC00012235
PMOID: PMO:00018744
Subclass_of: Steroids
Synonym: Heterocyclic Steroids
Synonym: Steroids, Heterocyclic [Chemical/Ingredient]
Synonym: heterocyclic steroids
Tree Number: T6.4.1.1.19
database_cross_reference: AOD:0000021041
database_cross_reference: MSH:D013260
database_cross_reference: NDFRT:N0000008179

Macrocyclic Compounds
type: Class
subclass of: Polycyclic Compounds
MCID: MC00516309
PMOID: PMO:00018747
Subclass_of: Polycyclic Compounds
Synonym: Compounds, Macrocycle
Synonym: Compounds, Macrocyclic
Synonym: MACROCYCLE CPDS
Synonym: MACROCYCLIC CPDS
Synonym: Macrocycle Compounds
Synonym: Macrocyclic Compounds [Chemical/Ingredient]
Synonym: Macrocyclic compounds
Tree Number: T6.4.5
database_cross_reference: LCH_NW:sh92002788
database_cross_reference: MSH:D047028
database_cross_reference: NDFRT:N0000011330

Cyclodextrins
type: Class
subclass of: Macrocyclic Compounds
MCID: MC00003408
PMOID: PMO:00018748
Subclass_of: Macrocyclic Compounds
Synonym: Cycloamylose
Synonym: Cyclodextrin Derivatives
Synonym: Cyclodextrins [Chemical/Ingredient]
Synonym: Cyclomaltooligosaccharides
Synonym: Derivatives, Cyclodextrin
Synonym: cyclodextrin
Synonym: cyclodextrins
Tree Number: T6.4.5.1
database_cross_reference: CHV:0000003522
database_cross_reference: CSP:1438-1433
database_cross_reference: LCH:U001232
database_cross_reference: LCH_NW:sh85035079
database_cross_reference: MSH:D003505
database_cross_reference: NDDF:014672
database_cross_reference: NDFRT:N0000168520
database_cross_reference: RXNORM:1426609

alpha-Cyclodextrins
type: Class
subclass of: Cyclodextrins
MCID: MC00516336
PMOID: PMO:00018749
Subclass_of: Cyclodextrins
Synonym: alpha Cyclodextrins
Synonym: alpha-Cyclodextrins [Chemical/Ingredient]
Tree Number: T6.4.5.1.1
database_cross_reference: MSH:D047391
database_cross_reference: NDFRT:N0000168521

beta-Cyclodextrins
type: Class
subclass of: Cyclodextrins
MCID: MC00516337
PMOID: PMO:00018750
Subclass_of: Cyclodextrins
Synonym: beta Cyclodextrins
Synonym: beta-Cyclodextrins [Chemical/Ingredient]
Tree Number: T6.4.5.1.2
database_cross_reference: MSH:D047392
database_cross_reference: NDFRT:N0000168523

gamma-Cyclodextrins
type: Class
subclass of: Cyclodextrins
MCID: MC00050636
PMOID: PMO:00018752
Subclass_of: Cyclodextrins
Synonym: gamma Cyclodextrins
Synonym: gamma-Cyclodextrins [Chemical/Ingredient]
Tree Number: T6.4.5.1.3
database_cross_reference: MSH:D047408
database_cross_reference: NDFRT:N0000168522

Peptides, Cyclic
type: Class
subclass of: Macrocyclic Compounds
subclass of: PMO:00021328
MCID: MC00009874
PMOID: PMO:00018753
Subclass_of: Macrocyclic Compounds
Subclass_of: Peptides
Synonym: Cyclic Peptides
Synonym: Cyclic peptide
Synonym: Cyclic peptide (substance)
Synonym: Cyclic peptides
Synonym: Cyclopeptides
Synonym: Peptides, Cyclic [Chemical/Ingredient]
Synonym: cyclic peptide
Synonym: cyclic peptides
Tree Number: T6.10.2.15
Tree Number: T6.4.5.4
database_cross_reference: CHV:0000009461
database_cross_reference: CSP:2237-5189
database_cross_reference: LCH_NW:sh89002721
database_cross_reference: MSH:D010456
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007875
database_cross_reference: SNOMEDCT_US:416590002

Alamethicin
type: Class
subclass of: Peptides, Cyclic
subclass of: PMO:00021864
MCID: MC00000495
PMOID: PMO:00018754
Subclass_of: Peptaibols
Subclass_of: Peptides, Cyclic
Synonym: Alamethicin [Chemical/Ingredient]
Tree Number: T6.10.2.15.1
Tree Number: T6.10.2.36.1
Tree Number: T6.4.5.4.1
database_cross_reference: MSH:D000408
database_cross_reference: NDFRT:N0000170361

Amanitins
type: Class
subclass of: Peptides, Cyclic
subclass of: PMO:00021376
subclass of: PMO:00024389
MCID: MC00000692
PMOID: PMO:00018755
Subclass_of: Mycotoxins
Subclass_of: Oligopeptides
Subclass_of: Peptides, Cyclic
Synonym: Amanitine
Synonym: Amanitine (substance)
Synonym: Amanitins [Chemical/Ingredient]
Synonym: Amanitotoxin
Synonym: amanitin
Synonym: amanitine
Synonym: amanitins
Tree Number: T6.10.2.13.2
Tree Number: T6.10.2.15.2
Tree Number: T6.13.8.6.2
Tree Number: T6.4.5.4.2
database_cross_reference: CHV:0000000967
database_cross_reference: CSP:2948-5085
database_cross_reference: LCH:U000178
database_cross_reference: LCH_NW:sh85004102
database_cross_reference: MSH:D000546
database_cross_reference: NDFRT:N0000171420
database_cross_reference: SNMI:C-30902
database_cross_reference: SNOMEDCT_US:61481008

Bacitracin
type: Class
subclass of: Peptides, Cyclic
MCID: MC00001461
PMOID: PMO:00018757
Subclass_of: Peptides, Cyclic
Synonym: 10 Person ANSI
Synonym: 25 Person ANSI
Synonym: 50 Person ANSI
Synonym: 7 Select First Aid Triple Antibiotic
Synonym: ACME FIRST AID Contains 404 PIECES
Synonym: ACME Small Cuts and Burns
Synonym: ARC FIRST AID Contains 1000 PIECES
Synonym: ARC FIRST AID Contains 404 PIECES
Synonym: Advanced First Aid Bacitracin
Synonym: Aerosoothe
Tree Number: T6.10.2.15.3
Tree Number: T6.4.5.4.3
database_cross_reference: AOD:0000019212
database_cross_reference: ATC:D06AX05
database_cross_reference: ATC:J01XX10
database_cross_reference: ATC:R02AB04
database_cross_reference: CHV:0000001659
database_cross_reference: CSP:0189-5476
database_cross_reference: DRUGBANK:DB00626
database_cross_reference: LCH:U000473
database_cross_reference: LCH_NW:sh85010784
database_cross_reference: LNC:LP14906-9
database_cross_reference: LNC:MTHU002155
database_cross_reference: MEDCIN:40274
database_cross_reference: MMSL:4241
database_cross_reference: MMSL:4917
database_cross_reference: MMSL:d01115
database_cross_reference: MSH:D001414
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:58H6RWO52I
database_cross_reference: NCI:C295
database_cross_reference: NCI_DTP:NSC0045737
database_cross_reference: NCI_FDA:58H6RWO52I
database_cross_reference: NDDF:002798
database_cross_reference: NDFRT:N0000006608
database_cross_reference: NDFRT:N0000145879
database_cross_reference: PDQ:CDR0000042858
database_cross_reference: RCD:X79H1
database_cross_reference: RXNORM:1291
database_cross_reference: SNM:E-7201
database_cross_reference: SNMI:C-52210
database_cross_reference: SNOMEDCT_US:255965000
database_cross_reference: SNOMEDCT_US:370330005
database_cross_reference: SNOMEDCT_US:5220000
database_cross_reference: USPMG:MTHU000234
database_cross_reference: VANDF:4017493

Capreomycin
type: Class
subclass of: Peptides, Cyclic
MCID: MC00088208
PMOID: PMO:00018758
Subclass_of: Peptides, Cyclic
Synonym: CAPREOMYCIN
Synonym: Capastat PWS IM 1g Vial
Synonym: Capreomycin (product)
Synonym: Capreomycin (substance)
Synonym: Capreomycin Complex
Synonym: Capreomycin [Chemical/Ingredient]
Synonym: Capromycin
Synonym: Helpomycin
Synonym: Kapocin
Synonym: Lykocin
Tree Number: T6.10.2.15.4
Tree Number: T6.4.5.4.4
database_cross_reference: ATC:J04AB30
database_cross_reference: CHV:0000025501
database_cross_reference: DRUGBANK:DB00314
database_cross_reference: LNC:LP16787-1
database_cross_reference: LNC:MTHU006861
database_cross_reference: MMSL:d01103
database_cross_reference: MSH:D002207
database_cross_reference: MTHSPL:232HYX66HC
database_cross_reference: NCI:C72607
database_cross_reference: NCI_FDA:232HYX66HC
database_cross_reference: NDDF:004901
database_cross_reference: NDFRT:N0000147744
database_cross_reference: NDFRT:N0000178639
database_cross_reference: RCD:ed1..
database_cross_reference: RXNORM:78903
database_cross_reference: SNM:E-7238
database_cross_reference: SNMI:C-55220
database_cross_reference: SNOMEDCT_US:14170004
database_cross_reference: SNOMEDCT_US:387081001
database_cross_reference: USPMG:MTHU000447
database_cross_reference: VANDF:4019652

Cyclosporins
type: Class
subclass of: Peptides, Cyclic
MCID: MC00003434
PMOID: PMO:00018759
Subclass_of: Peptides, Cyclic
Synonym: Cyclosporine
Synonym: Cyclosporines
Synonym: Cyclosporins [Chemical/Ingredient]
Synonym: cyclosporines
Synonym: cyclosporines (medication)
Synonym: cyclosporins
Tree Number: T6.10.2.15.5
Tree Number: T6.4.5.4.5
database_cross_reference: CHV:0000003533
database_cross_reference: LCH_NW:sh85035108
database_cross_reference: MEDCIN:257550
database_cross_reference: MSH:D003524
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007903

Enterobactin
type: Class
subclass of: Peptides, Cyclic
MCID: MC00004538
PMOID: PMO:00018761
Subclass_of: Peptides, Cyclic
Synonym: Benzamide, N,N',N''-(2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7,11-triyl)tris(2,3-dihydroxy-, (3S-(3R*,7R*,11R*)))-
Synonym: Enterobactin [Chemical/Ingredient]
Synonym: Enterochelin
Tree Number: T6.10.2.15.8
Tree Number: T6.4.5.4.8
database_cross_reference: MSH:D004758
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170221

Mycobacillin
type: Class
subclass of: Peptides, Cyclic
MCID: MC00008516
PMOID: PMO:00018762
Subclass_of: Peptides, Cyclic
Synonym: Mycobacillin [Chemical/Ingredient]
Tree Number: T6.10.2.15.10
Tree Number: T6.4.5.4.10
database_cross_reference: MSH:D009158
database_cross_reference: NDFRT:N0000170366

Nisin
type: Class
subclass of: Peptides, Cyclic
MCID: MC00008914
PMOID: PMO:00018763
Subclass_of: Peptides, Cyclic
Synonym: Nisin [Chemical/Ingredient]
Synonym: nisin
Tree Number: T6.10.2.15.11
Tree Number: T6.4.5.4.11
database_cross_reference: CHV:0000008726
database_cross_reference: LCH:U003237
database_cross_reference: LCH_NW:sh85092029
database_cross_reference: MSH:D009561
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170349

Phalloidine
type: Class
subclass of: Peptides, Cyclic
subclass of: PMO:00021376
subclass of: PMO:00024389
MCID: MC00009982
PMOID: PMO:00018764
Subclass_of: Mycotoxins
Subclass_of: Oligopeptides
Subclass_of: Peptides, Cyclic
Synonym: Phalloidin
Synonym: Phalloidine [Chemical/Ingredient]
Synonym: phalloidine
Tree Number: T6.10.2.13.17
Tree Number: T6.10.2.15.12
Tree Number: T6.13.8.6.11
Tree Number: T6.4.5.4.12
database_cross_reference: AOD:0000020276
database_cross_reference: LCH:U003591
database_cross_reference: LCH_NW:sh85100565
database_cross_reference: MSH:D010590
database_cross_reference: NDFRT:N0000171408

Polymyxins
type: Class
subclass of: Peptides, Cyclic
subclass of: PMO:00021254
subclass of: PMO:00021450
MCID: MC00010441
PMOID: PMO:00018765
Subclass_of: Antimicrobial Cationic Peptides
Subclass_of: Lipopeptides
Subclass_of: Peptides, Cyclic
Synonym: Polymyxin
Synonym: Polymyxins (product)
Synonym: Polymyxins (substance)
Synonym: Polymyxins [Chemical/Ingredient]
Synonym: polymyxin
Synonym: polymyxin preparations
Synonym: polymyxin preparations (medication)
Synonym: polymyxins
Tree Number: T6.10.2.15.13
Tree Number: T6.10.2.28.2
Tree Number: T6.4.5.4.13
Tree Number: T6.9.15.1
database_cross_reference: ATC:J01XB
database_cross_reference: CHV:0000009928
database_cross_reference: LCH:U003759
database_cross_reference: LCH_NW:sh85104686
database_cross_reference: MEDCIN:40326
database_cross_reference: MSH:D011113
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007822
database_cross_reference: RCD:x009g
database_cross_reference: SNOMEDCT_US:346638008
database_cross_reference: SNOMEDCT_US:373224006

Colistin
type: Class
subclass of: Polymyxins
MCID: MC00003077
PMOID: PMO:00018766
Subclass_of: Polymyxins
Synonym: Alfacolin
Synonym: Alficetin
Synonym: COLISTIN
Synonym: ColiFin
Synonym: Colimicina
Synonym: Colimycin
Synonym: Colimycine
Synonym: Coliracin
Synonym: Colistate
Synonym: Colisticin
Tree Number: T6.9.15.1.1
database_cross_reference: ATC:A07AA10
database_cross_reference: ATC:J01XB01
database_cross_reference: CHV:0000003152
database_cross_reference: DRUGBANK:DB00803
database_cross_reference: LNC:LP15474-7
database_cross_reference: LNC:MTHU006916
database_cross_reference: MSH:D003091
database_cross_reference: MTHSPL:Z67X93HJG1
database_cross_reference: NCI:C386
database_cross_reference: NCI:C65350
database_cross_reference: NCI_FDA:Z67X93HJG1
database_cross_reference: NDDF:004903
database_cross_reference: NDFRT:N0000006763
database_cross_reference: NDFRT:N0000147787
database_cross_reference: PDQ:CDR0000041545
database_cross_reference: RCD:eb3..
database_cross_reference: RXNORM:2709
database_cross_reference: SNM:E-7205
database_cross_reference: SNMI:C-52230
database_cross_reference: SNMI:C-52240
database_cross_reference: SNOMEDCT_US:387412007
database_cross_reference: SNOMEDCT_US:55594000
database_cross_reference: SNOMEDCT_US:73074003
database_cross_reference: VANDF:4019695

Polymyxin B
type: Class
subclass of: Polymyxins
MCID: MC00010439
PMOID: PMO:00018767
Subclass_of: Polymyxins
Synonym: POLYMYXIN B
Synonym: Polimixina B
Synonym: Polymyxin B (product)
Synonym: Polymyxin B (substance)
Synonym: Polymyxin B [Chemical/Ingredient]
Synonym: Polymyxine B
Synonym: Polymyxinum B
Synonym: b polymyxin
Synonym: polymyxin B
Synonym: polymyxin b
Tree Number: T6.9.15.1.2
database_cross_reference: ATC:A07AA05
database_cross_reference: ATC:J01XB02
database_cross_reference: ATC:S01AA18
database_cross_reference: ATC:S02AA11
database_cross_reference: ATC:S03AA03
database_cross_reference: CHV:0000009927
database_cross_reference: CSP:0189-5476
database_cross_reference: DRUGBANK:DB00781
database_cross_reference: LNC:LP16319-3
database_cross_reference: LNC:MTHU007602
database_cross_reference: MMSL:5317
database_cross_reference: MSH:D011112
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:J2VZ07J96K
database_cross_reference: NCI:C61894
database_cross_reference: NCI_FDA:J2VZ07J96K
database_cross_reference: NDDF:004902
database_cross_reference: NDFRT:N0000007407
database_cross_reference: NDFRT:N0000146910
database_cross_reference: RCD:x02Lu
database_cross_reference: RXNORM:8536
database_cross_reference: SNM:E-7222
database_cross_reference: SNMI:C-52270
database_cross_reference: SNOMEDCT_US:372824005
database_cross_reference: SNOMEDCT_US:6960003
database_cross_reference: USPMG:MTHU002209
database_cross_reference: VANDF:4018594

Thiostrepton
type: Class
subclass of: Peptides, Cyclic
MCID: MC00012755
PMOID: PMO:00018768
Subclass_of: Peptides, Cyclic
Synonym: THIOSTREPTON
Synonym: Thiostrepton (substance)
Synonym: Thiostrepton [Chemical/Ingredient]
Synonym: thiostrepton
Tree Number: T6.10.2.15.14
Tree Number: T6.4.5.4.14
database_cross_reference: CHV:0000012194
database_cross_reference: MSH:D013883
database_cross_reference: MTHSPL:HR4S203Y18
database_cross_reference: NDFRT:N0000170348
database_cross_reference: RXNORM:1365970
database_cross_reference: SNMI:C-52320
database_cross_reference: SNOMEDCT_US:96017003

Tyrothricin
type: Class
subclass of: Peptides, Cyclic
MCID: MC00013270
PMOID: PMO:00018769
Subclass_of: Peptides, Cyclic
Synonym: Tyrothricin (product)
Synonym: Tyrothricin (substance)
Synonym: Tyrothricin [Chemical/Ingredient]
Synonym: tyrothricin
Tree Number: T6.10.2.15.15
Tree Number: T6.4.5.4.15
database_cross_reference: ATC:D06AX08
database_cross_reference: ATC:R02AB02
database_cross_reference: ATC:S01AA05
database_cross_reference: MSH:D014449
database_cross_reference: NDDF:002800
database_cross_reference: NDFRT:N0000007931
database_cross_reference: RXNORM:10968
database_cross_reference: SNM:E-7232
database_cross_reference: SNMI:C-906B0
database_cross_reference: SNOMEDCT_US:36661005
database_cross_reference: SNOMEDCT_US:404827006

Viomycin
type: Class
subclass of: Peptides, Cyclic
MCID: MC00013571
PMOID: PMO:00018772
Subclass_of: Peptides, Cyclic
Synonym: Florimycin
Synonym: Floromycin
Synonym: Tuberactinomycin B
Synonym: VIOMYCIN
Synonym: Viomicin
Synonym: Viomycin (substance)
Synonym: Viomycin [Chemical/Ingredient]
Synonym: Viomycine
Synonym: viomicin
Synonym: viomycin
Tree Number: T6.10.2.15.16
Tree Number: T6.4.5.4.16
database_cross_reference: CHV:0000013005
database_cross_reference: DRUGBANK:DB06827
database_cross_reference: LCH:U004952
database_cross_reference: LCH_NW:sh85143716
database_cross_reference: LNC:LP16733-5
database_cross_reference: LNC:MTHU008496
database_cross_reference: MSH:D014756
database_cross_reference: NCI:C66654
database_cross_reference: NCI_FDA:YVU35998K5
database_cross_reference: NDDF:002773
database_cross_reference: NDFRT:N0000170363
database_cross_reference: SNM:E-7347
database_cross_reference: SNMI:C-55294
database_cross_reference: SNOMEDCT_US:19967004

Octreotide
type: Class
subclass of: Peptides, Cyclic
MCID: MC00009104
PMOID: PMO:00018774
Subclass_of: Peptides, Cyclic
Synonym: D-Phenylalanyl-L-cysteinyl-L-phenyl-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide Cyclic (2->7)-Disulfide
Synonym: D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol Cyclic (2->7)-Disulfide
Synonym: D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hyroxymethyl)propyl]-L-cysteinamide, Cyclic (2->7)-disulfide
Synonym: L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2-7)-disulfide, (R-(R*,R*))-
Synonym: OCTREOTIDE
Synonym: Ocphyl
Synonym: Octreotida
Synonym: Octreotide (substance)
Synonym: Octreotide Acetate Omega 100mcg/ml
Synonym: Octreotide Acetate Omega 200mcg/ml
Tree Number: T6.10.2.15.17
Tree Number: T6.4.5.4.17
database_cross_reference: ATC:H01CB02
database_cross_reference: CHV:0000008891
database_cross_reference: CSP:4007-0092
database_cross_reference: DRUGBANK:DB00104
database_cross_reference: LNC:LP97954-9
database_cross_reference: LNC:MTHU035158
database_cross_reference: MMSL:d00370
database_cross_reference: MSH:D015282
database_cross_reference: MTHSPL:RWM8CCW8GP
database_cross_reference: NCI:C711
database_cross_reference: NCI_DCP:02189
database_cross_reference: NCI_FDA:RWM8CCW8GP
database_cross_reference: NCI_NCI-GLOSS:CDR0000045141
database_cross_reference: NDDF:002107
database_cross_reference: NDFRT:N0000007125
database_cross_reference: NDFRT:N0000147950
database_cross_reference: RCD:he6..
database_cross_reference: RXNORM:7617
database_cross_reference: SNOMEDCT_US:109053000
database_cross_reference: SNOMEDCT_US:126155003
database_cross_reference: USPMG:MTHU001223
database_cross_reference: VANDF:4019864

Daptomycin
type: Class
subclass of: Peptides, Cyclic
subclass of: PMO:00021254
MCID: MC00024233
PMOID: PMO:00018775
Subclass_of: Lipopeptides
Subclass_of: Peptides, Cyclic
Synonym: DAPTOMYCIN
Synonym: DAPTOmycin
Synonym: Daptomycin (product)
Synonym: Daptomycin (substance)
Synonym: Daptomycin [Chemical/Ingredient]
Synonym: Deptomycin
Synonym: N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
Synonym: N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine-epsilon1-lactone
Synonym: daptomycin
Synonym: daptomycin (medication)
Tree Number: T6.10.2.15.18
Tree Number: T6.10.2.37.1
Tree Number: T6.4.5.4.18
Tree Number: T6.9.15.2
database_cross_reference: ATC:J01XX09
database_cross_reference: DRUGBANK:DB00080
database_cross_reference: LNC:LP33354-9
database_cross_reference: LNC:MTHU016673
database_cross_reference: MEDCIN:258859
database_cross_reference: MMSL:17565
database_cross_reference: MMSL:244166
database_cross_reference: MMSL:d04894
database_cross_reference: MSH:D017576
database_cross_reference: MTHSPL:NWQ5N31VKK
database_cross_reference: NCI:C47470
database_cross_reference: NCI_FDA:NWQ5N31VKK
database_cross_reference: NCI_NCI-GLOSS:CDR0000471776
database_cross_reference: NDDF:003222
database_cross_reference: NDFRT:N0000010342
database_cross_reference: NDFRT:N0000148828
database_cross_reference: PDQ:CDR0000469015
database_cross_reference: RXNORM:22299
database_cross_reference: SNOMEDCT_US:406438001
database_cross_reference: SNOMEDCT_US:406439009
database_cross_reference: USPMG:MTHU000237
database_cross_reference: VANDF:4021414

Streptogramins
type: Class
subclass of: Peptides, Cyclic
MCID: MC00067251
PMOID: PMO:00018776
Subclass_of: Peptides, Cyclic
Synonym: Streptogramin
Synonym: Streptogramin (product)
Synonym: Streptogramin (substance)
Synonym: Streptogramins [Chemical/Ingredient]
Synonym: streptogramin
Synonym: streptogramins
Tree Number: T6.10.2.15.19
Tree Number: T6.4.5.4.19
database_cross_reference: ATC:J01FG
database_cross_reference: CHV:0000020765
database_cross_reference: LCH_NW:sh98003484
database_cross_reference: MSH:D025361
database_cross_reference: NDFRT:N0000011418
database_cross_reference: SNOMEDCT_US:420946006
database_cross_reference: SNOMEDCT_US:422292008

Depsipeptides
type: Class
subclass of: Peptides, Cyclic
MCID: MC00275831
PMOID: PMO:00018785
Subclass_of: Peptides, Cyclic
Synonym: Depsipeptides [Chemical/Ingredient]
Tree Number: T6.10.2.15.22
Tree Number: T6.4.5.4.20
database_cross_reference: MSH:D047630
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170351

Microcystins
type: Class
subclass of: Peptides, Cyclic
MCID: MC00068820
PMOID: PMO:00018787
Subclass_of: Peptides, Cyclic
Synonym: Microcystin
Synonym: Microcystin (substance)
Synonym: microcystin
Synonym: microcystins
Tree Number: T6.10.2.15.23
Tree Number: T6.4.5.4.21
database_cross_reference: CHV:0000021111
database_cross_reference: MSH:C078588
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:370453005

Crown Compounds
type: Class
subclass of: Macrocyclic Compounds
MCID: MC00539335
PMOID: PMO:00018788
Subclass_of: Macrocyclic Compounds
Synonym: CROWN CPDS
Synonym: Compounds, Crown
Synonym: Crown Compounds [Chemical/Ingredient]
Tree Number: T6.4.5.8
database_cross_reference: MSH:D047248
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167395

Calixarenes
type: Class
subclass of: Macrocyclic Compounds
MCID: MC00048277
PMOID: PMO:00018789
Subclass_of: Macrocyclic Compounds
Synonym: Calix(n)Arenes
Synonym: Calixarene
Synonym: Calixarenes [Chemical/Ingredient]
Tree Number: T6.4.5.9
database_cross_reference: LCH_NW:sh90000799
database_cross_reference: MSH:D047250
database_cross_reference: NDFRT:N0000167390

Macromolecular Substances
type: Class
subclass of: Chemical and Drug
MCID: MC00516300
PMOID: PMO:00018790
Subclass_of: Chemical and Drug
Synonym: Macromolecular Compounds and Complexes
Synonym: Macromolecular Substances [Chemical/Ingredient]
Synonym: Substances, Macromolecular
Tree Number: T6.5
database_cross_reference: MSH:D046911
database_cross_reference: NDFRT:N0000167471

Micelles
type: Class
subclass of: Macromolecular Substances
subclass of: PMO:00024444
MCID: MC00008274
PMOID: PMO:00018791
Subclass_of: Dosage Forms
Subclass_of: Macromolecular Substances
Synonym: Micelle
Synonym: Micelles [Chemical/Ingredient]
Synonym: micelle
Synonym: micelles
Tree Number: T6.15.2.7
Tree Number: T6.5.1
database_cross_reference: AOD:0000001135
database_cross_reference: CHV:0000008088
database_cross_reference: CSP:0628-7023
database_cross_reference: LCH:U002955
database_cross_reference: LCH_NW:sh85084678
database_cross_reference: MSH:D008823
database_cross_reference: NCI:C93299
database_cross_reference: NCI_NCI-GLOSS:CDR0000648995
database_cross_reference: NDFRT:N0000175109

Polymers
type: Class
subclass of: Macromolecular Substances
subclass of: PMO:00024401
MCID: MC00010435
PMOID: PMO:00018792
Subclass_of: Biomedical and Dental Materials
Subclass_of: Macromolecular Substances
Synonym: POLYMER SUBSTANCE
Synonym: Polymer
Synonym: Polymer (substance)
Synonym: Polymeric
Synonym: Polymeric Macromolecules
Synonym: Polymers [Chemical/Ingredient]
Synonym: polymer
Synonym: polymers
Tree Number: T6.14.9
Tree Number: T6.5.2
database_cross_reference: AOD:0000021057
database_cross_reference: CHV:0000009924
database_cross_reference: CSP:1946-1804
database_cross_reference: LCH_NW:sh85104660
database_cross_reference: MSH:D011108
database_cross_reference: NCI:C48803
database_cross_reference: NCI_FDA:C48803
database_cross_reference: NCI_NCI-GLOSS:CDR0000601172
database_cross_reference: NDFRT:N0000007820
database_cross_reference: SNOMEDCT_US:412155002

Biopolymers
type: Class
subclass of: Polymers
MCID: MC00001760
PMOID: PMO:00018793
Subclass_of: Polymers
Synonym: Biopolymer
Synonym: Biopolymer (substance)
Synonym: Biopolymers [Chemical/Ingredient]
Synonym: biopolymer
Synonym: biopolymers
Tree Number: T6.14.9.1
Tree Number: T6.5.2.3
database_cross_reference: CHV:0000001908
database_cross_reference: CSP:4007-0013
database_cross_reference: LCH:U000580
database_cross_reference: LCH_NW:sh85014255
database_cross_reference: MSH:D001704
database_cross_reference: NCI:C73478
database_cross_reference: NDFRT:N0000011232
database_cross_reference: SNOMEDCT_US:426077003

Chitin
type: Class
subclass of: Biopolymers
subclass of: PMO:00020992
MCID: MC00002625
PMOID: PMO:00018794
Subclass_of: Biopolymers
Subclass_of: Polysaccharides
Synonym: Chitin [Chemical/Ingredient]
Synonym: chitin
Tree Number: T6.5.2.3.1
Tree Number: T6.8.7.3
database_cross_reference: CHV:0000002803
database_cross_reference: CSP:2452-0995
database_cross_reference: LCH:U000962
database_cross_reference: LCH_NW:sh85024494
database_cross_reference: MSH:D002686
database_cross_reference: NCI:C93334
database_cross_reference: NCI_NCI-GLOSS:CDR0000285965
database_cross_reference: NDFRT:N0000168509

Chitosan
type: Class
subclass of: Chitin
MCID: MC00063510
PMOID: PMO:00018795
Subclass_of: Chitin
Synonym: CHITOSAN
Synonym: Chitosan [Chemical/Ingredient]
Synonym: Poliglusam
Synonym: chitosan
Synonym: chitosans
Tree Number: T6.8.7.3.1
database_cross_reference: CHV:0000018025
database_cross_reference: DRUGBANK:DB11234
database_cross_reference: LCH_NW:sh85024498
database_cross_reference: MSH:D048271
database_cross_reference: NDDF:008107
database_cross_reference: NDFRT:N0000168510
database_cross_reference: NDFRT:N0000180857
database_cross_reference: RXNORM:59038
database_cross_reference: VANDF:4029765

Collagen
type: Class
subclass of: Biopolymers
MCID: MC00003081
PMOID: PMO:00018796
Subclass_of: Biopolymers
Synonym: Collagen (substance)
Synonym: Collagen [Chemical/Ingredient]
Synonym: Collagen [haemostatic]
Synonym: Collagen [hemostatic]
Synonym: Collagen [hemostatic] (product)
Synonym: Collagen [hemostatic] (substance)
Synonym: Collagen product
Synonym: Collagen product (product)
Synonym: Collagen product (substance)
Synonym: Collagens
Tree Number: T6.5.2.3.2
database_cross_reference: AOD:0000020321
database_cross_reference: ATC:B02BC07
database_cross_reference: ATC:G04BX11
database_cross_reference: CHV:0000003156
database_cross_reference: CSP:2447-0300
database_cross_reference: FMA:63891
database_cross_reference: LCH:U001092
database_cross_reference: LCH_NW:sh85027969
database_cross_reference: LNC:LP18176-5
database_cross_reference: MEDCIN:48571
database_cross_reference: MMSL:22949
database_cross_reference: MMSL:d06214
database_cross_reference: MSH:D003094
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16447
database_cross_reference: NCI_NCI-GLOSS:CDR0000044196
database_cross_reference: NDDF:002016
database_cross_reference: NDFRT:N0000006771
database_cross_reference: RCD:XM0lo
database_cross_reference: RCD:bw7..
database_cross_reference: RCD:x01O9
database_cross_reference: RCDAE:bw7..
database_cross_reference: RXNORM:2714
database_cross_reference: SNM:F-13040
database_cross_reference: SNM:T-1X050
database_cross_reference: SNMI:F-62840
database_cross_reference: SNOMEDCT_US:319902009
database_cross_reference: SNOMEDCT_US:350476009
database_cross_reference: SNOMEDCT_US:61472002
database_cross_reference: UWDA:63891

Elastin
type: Class
subclass of: Biopolymers
MCID: MC00004341
PMOID: PMO:00018803
Subclass_of: Biopolymers
Synonym: ELN
Synonym: Elastin (substance)
Synonym: Elastin [Chemical/Ingredient]
Synonym: Elastins
Synonym: Tropoelastin
Synonym: elastin
Synonym: elastin tissue
Tree Number: T6.5.2.3.3
database_cross_reference: AOD:0000016858
database_cross_reference: CHV:0000004314
database_cross_reference: CSP:2447-0700
database_cross_reference: FMA:67303
database_cross_reference: LCH:U001519
database_cross_reference: LCH_NW:sh85041518
database_cross_reference: MSH:D004549
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75335
database_cross_reference: NDDF:006575
database_cross_reference: NDFRT:N0000007011
database_cross_reference: RXNORM:1730435
database_cross_reference: SNM:F-13080
database_cross_reference: SNMI:F-62880
database_cross_reference: SNOMEDCT_US:1471007
database_cross_reference: UWDA:67303

Glucans
type: Class
subclass of: Biopolymers
subclass of: PMO:00020992
MCID: MC00005658
PMOID: PMO:00018804
Subclass_of: Biopolymers
Subclass_of: Polysaccharides
Synonym: Glucans [Chemical/Ingredient]
Synonym: Glucose Polymer
Synonym: Polyglucoses
Synonym: Polymer, Glucose
Synonym: dietary supplements glucose polymers
Synonym: glucan
Synonym: glucans
Synonym: glucose polymers
Synonym: glucose polymers (medication)
Synonym: polyglucose
Tree Number: T6.5.2.3.4
Tree Number: T6.8.7.7
database_cross_reference: AOD:0000019823
database_cross_reference: CHV:0000005554
database_cross_reference: CSP:1438-0629
database_cross_reference: LCH:U001986
database_cross_reference: LCH_NW:sh85055355
database_cross_reference: MEDCIN:41261
database_cross_reference: MSH:D005936
database_cross_reference: NDDF:000950
database_cross_reference: NDFRT:N0000007623

Cellulose
type: Class
subclass of: Biopolymers
subclass of: Glucans
MCID: MC00002469
PMOID: PMO:00018805
Subclass_of: Biopolymers
Subclass_of: Glucans
Synonym: .ALPHA.-CELLULOSE
Synonym: ALPHA CELLULOSE
Synonym: Acid, Polyanhydroglucuronic
Synonym: CELLULOSE
Synonym: Cellulose (substance)
Synonym: Cellulose [Chemical/Ingredient]
Synonym: Cellulose preparation
Synonym: Cellulose preparation (product)
Synonym: Cellulose preparation (substance)
Synonym: Polyanhydroglucuronic Acid
Tree Number: T6.14.9.1.1
Tree Number: T6.8.7.7.1
database_cross_reference: AOD:0000019826
database_cross_reference: CHV:0000002610
database_cross_reference: CSP:1438-1232
database_cross_reference: FMA:82748
database_cross_reference: LCH:U000876
database_cross_reference: LCH_NW:sh85021705
database_cross_reference: MMSL:4391
database_cross_reference: MMSL:d04249
database_cross_reference: MSH:D002482
database_cross_reference: MTHSPL:I355QGZ19A
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: MTHSPL:SMD1X3XO9M
database_cross_reference: NCI:C68491
database_cross_reference: NCI_CRCH:C68491
database_cross_reference: NCI_NCI-GLOSS:CDR0000476320
database_cross_reference: NDDF:002438
database_cross_reference: NDFRT:N0000005997
database_cross_reference: NDFRT:N0000147309
database_cross_reference: RCD:Ub09H
database_cross_reference: RXNORM:2221
database_cross_reference: SNM:F-12130
database_cross_reference: SNMI:F-61C30
database_cross_reference: SNOMEDCT_US:116527009
database_cross_reference: SNOMEDCT_US:387028009
database_cross_reference: SNOMEDCT_US:68992005
database_cross_reference: VANDF:4019039

Lignin
type: Class
subclass of: Biopolymers
subclass of: PMO:00024102
MCID: MC00007571
PMOID: PMO:00018807
Subclass_of: Biopolymers
Subclass_of: Complex Mixtures
Synonym: Lignin [Chemical/Ingredient]
Synonym: Lignins
Synonym: Lignins (substance)
Synonym: lignin
Synonym: lignins
Tree Number: T6.12.6
Tree Number: T6.14.9.1.3
Tree Number: T6.5.2.3.7
database_cross_reference: AOD:0000019827
database_cross_reference: CHV:0000007427
database_cross_reference: CSP:2341-7255
database_cross_reference: LCH:U002699
database_cross_reference: LCH_NW:sh85076945
database_cross_reference: MSH:D008031
database_cross_reference: NCI:C63638
database_cross_reference: NCI_CRCH:C63638
database_cross_reference: NCI_DCP:5331
database_cross_reference: NDFRT:N0000171528
database_cross_reference: RCD:Ub09K
database_cross_reference: SNM:F-12150
database_cross_reference: SNMI:F-61C50
database_cross_reference: SNOMEDCT_US:1991005

Dextrans
type: Class
subclass of: Glucans
MCID: MC00003782
PMOID: PMO:00018809
Subclass_of: Glucans
Synonym: Dextran Derivatives
Synonym: Dextrans [Chemical/Ingredient]
Synonym: dextrans
Synonym: dextrans (medication)
Synonym: plasma expanders dextrans
Tree Number: T6.8.7.7.2
database_cross_reference: MEDCIN:250552
database_cross_reference: MSH:D003911
database_cross_reference: NDFRT:N0000006146

Glycogen
type: Class
subclass of: Glucans
PMOID: PMO:00018810
Subclass_of: Glucans
Tree Number: T6.8.7.7.3

Starch
type: Class
subclass of: Glucans
subclass of: PMO:00020915
MCID: MC00012200
PMOID: PMO:00018812
Subclass_of: Dietary Carbohydrates
Subclass_of: Glucans
Synonym: STARCH
Synonym: Starch (product)
Synonym: Starch (substance)
Synonym: Starch [Chemical/Ingredient]
Synonym: Starch, NOS
Synonym: starch
Synonym: starches
Tree Number: T6.8.4.3
Tree Number: T6.8.7.7.6
database_cross_reference: AOD:0000019828
database_cross_reference: CHV:0000011699
database_cross_reference: CSP:1438-3041
database_cross_reference: LCH:U004462
database_cross_reference: LCH_NW:sh85127386
database_cross_reference: LNC:LP100184-3
database_cross_reference: LNC:MTHU036055
database_cross_reference: MMSL:5511
database_cross_reference: MSH:D013213
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C68488
database_cross_reference: NCI_CRCH:C68488
database_cross_reference: NCI_NCI-GLOSS:CDR0000614169
database_cross_reference: NDDF:002433
database_cross_reference: NDFRT:N0000006758
database_cross_reference: NDFRT:N0000147310
database_cross_reference: RCD:Xa6ZI
database_cross_reference: RXNORM:10046
database_cross_reference: SNM:F-12110
database_cross_reference: SNMI:F-61C10
database_cross_reference: SNOMEDCT_US:39360003
database_cross_reference: SNOMEDCT_US:412339002
database_cross_reference: VANDF:4019040

Inulin
type: Class
subclass of: Starch
subclass of: PMO:00020996
MCID: MC00006983
PMOID: PMO:00018813
Subclass_of: Fructans
Subclass_of: Starch
Synonym: INULIN
Synonym: Inulin (substance)
Synonym: Inulin USP 27
Synonym: Inulin [Chemical/Ingredient]
Synonym: Inulin from Jerusalem artichokes
Synonym: inulin
Tree Number: T6.8.4.3.5
Tree Number: T6.8.7.5.1
database_cross_reference: CHV:0000006889
database_cross_reference: CSP:1438-3845
database_cross_reference: DRUGBANK:DB00638
database_cross_reference: LCH:U002492
database_cross_reference: LCH_NW:sh85067660
database_cross_reference: LNC:LP15675-9
database_cross_reference: LNC:MTHU012086
database_cross_reference: MMSL:17140
database_cross_reference: MMSL:d04848
database_cross_reference: MSH:D007444
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:JOS53KRJ01
database_cross_reference: NCI:C61506
database_cross_reference: NCI_CRCH:C61506
database_cross_reference: NCI_DCP:09361
database_cross_reference: NCI_FDA:JOS53KRJ01
database_cross_reference: NDDF:002342
database_cross_reference: NDFRT:N0000007167
database_cross_reference: NDFRT:N0000147140
database_cross_reference: PDQ:CDR0000486745
database_cross_reference: RCD:X807h
database_cross_reference: RXNORM:5924
database_cross_reference: SNM:E-8115
database_cross_reference: SNMI:C-B0158
database_cross_reference: SNOMEDCT_US:259103000
database_cross_reference: SNOMEDCT_US:32154009
database_cross_reference: VANDF:4018838

Intermediate Filament Proteins
type: Class
subclass of: Biopolymers
subclass of: PMO:00022569
MCID: MC00006937
PMOID: PMO:00018814
Subclass_of: Biopolymers
Subclass_of: Cytoskeletal Proteins
Synonym: Fibroblast Intermediate Filament Proteins
Synonym: Filament Proteins, Intermediate
Synonym: IFP
Synonym: Intermediate Filament Protein
Synonym: Intermediate Filament Proteins [Chemical/Ingredient]
Synonym: Intermediate filament protein
Synonym: Intermediate filament proteins
Synonym: Proteins, Intermediate Filament
Tree Number: T6.10.3.16.2
Tree Number: T6.5.2.3.5
database_cross_reference: FMA:67295
database_cross_reference: LCH:U002472
database_cross_reference: LCH_NW:sh85067297
database_cross_reference: MSH:D007381
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C20694
database_cross_reference: NDFRT:N0000169471
database_cross_reference: UWDA:67295

Keratins
type: Class
subclass of: PMO:00023715
MCID: MC00003502
PMOID: PMO:00018817
Subclass_of: Scleroproteins
Synonym: Cytokeratin
Synonym: Cytokeratin (substance)
Synonym: Keratin
Synonym: Keratins [Chemical/Ingredient]
Synonym: cytokeratin
Synonym: cytokeratins
Synonym: keratin
Tree Number: T6.10.3.51.2
database_cross_reference: AOD:0000020318
database_cross_reference: CHV:0000003580
database_cross_reference: CSP:2447-0900
database_cross_reference: FMA:67302
database_cross_reference: LCH:U002568
database_cross_reference: LNC:LP14679-2
database_cross_reference: LNC:LP18175-7
database_cross_reference: MSH:D007633
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C20693
database_cross_reference: NCI:TCGA
database_cross_reference: NDFRT:N0000169473
database_cross_reference: RCD:X80h2
database_cross_reference: SNOMEDCT_US:259987000
database_cross_reference: UWDA:67302

Neurofilament Proteins
type: Class
subclass of: PMO:00023612
MCID: MC00043298
PMOID: PMO:00018841
Subclass_of: Nerve Tissue Proteins
Synonym: NFP
Synonym: Neurofilament Proteins [Chemical/Ingredient]
Synonym: Neurofilament protein
Synonym: Neurofilament protein (substance)
Synonym: Proteins, Neurofilament
Synonym: neurofilament protein
Tree Number: T6.10.3.35.17
database_cross_reference: CSP:2037-5637
database_cross_reference: FMA:67344
database_cross_reference: MSH:D016900
database_cross_reference: NDFRT:N0000169476
database_cross_reference: SNOMEDCT_US:385480007
database_cross_reference: UWDA:67344

Nestin
type: Class
subclass of: PMO:00023612
MCID: MC00033090
PMOID: PMO:00018842
Subclass_of: Nerve Tissue Proteins
Synonym: Nestin Protein
Synonym: Nestin [Chemical/Ingredient]
Synonym: Protein, Nestin
Synonym: nestin
Synonym: nestin protein
Tree Number: T6.10.3.35.36
database_cross_reference: CHV:0000014489
database_cross_reference: FMA:67401
database_cross_reference: MSH:D064231
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C104562
database_cross_reference: NDFRT:N0000189402
database_cross_reference: UWDA:67401

Latex
type: Class
subclass of: Biopolymers
subclass of: PMO:00024202
MCID: MC00007393
PMOID: PMO:00018844
Subclass_of: Biopolymers
Subclass_of: Plant Exudates
Synonym: LATEX
Synonym: Latex (product)
Synonym: Latex (substance)
Synonym: Latex [Chemical/Ingredient]
Synonym: Latice
Synonym: Latices
Synonym: latex
Synonym: latice
Tree Number: T6.12.2.6.2
Tree Number: T6.14.9.1.2
Tree Number: T6.5.2.3.6
database_cross_reference: CHV:0000007240
database_cross_reference: CSP:2349-0686
database_cross_reference: LCH:U002629
database_cross_reference: LCH_NW:sh85074851
database_cross_reference: LNC:LP17009-9
database_cross_reference: MSH:D007840
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:008921
database_cross_reference: NDFRT:N0000007394
database_cross_reference: NDFRT:N0000178089
database_cross_reference: RCD:X80sl
database_cross_reference: RXNORM:1314891
database_cross_reference: SNMI:C-20033
database_cross_reference: SNOMEDCT_US:111088007
database_cross_reference: SNOMEDCT_US:400664008
database_cross_reference: VANDF:4021240

Microfilament Proteins
type: Class
subclass of: Biopolymers
subclass of: PMO:00022569
MCID: MC00008284
PMOID: PMO:00018845
Subclass_of: Biopolymers
Subclass_of: Cytoskeletal Proteins
Synonym: Microfilament Protein
Synonym: Microfilament Proteins [Chemical/Ingredient]
Synonym: Proteins, Microfilament
Tree Number: T6.10.3.16.3
Tree Number: T6.5.2.3.8
database_cross_reference: MSH:D008840
database_cross_reference: NCI:C16852
database_cross_reference: NDFRT:N0000169429

Myristoylated Alanine-Rich C Kinase Substrate
type: Class
subclass of: PMO:00021684
subclass of: PMO:00023060
MCID: MC00031911
PMOID: PMO:00018847
Subclass_of: Intracellular Signaling Peptides and Proteins
Subclass_of: Membrane Proteins
Synonym: ACAMP-81
Synonym: MARCKS protein
Synonym: myristoylated alanine-rich C kinase substrate
Tree Number: T6.10.2.33.10
Tree Number: T6.10.3.32.10
Tree Number: T6.10.3.86.9
database_cross_reference: MSH:C059988

Troponin
type: Class
subclass of: Multiprotein Complexes
MCID: MC00013161
PMOID: PMO:00018867
Subclass_of: Multiprotein Complexes
Synonym: Troponin (substance)
Synonym: Troponin Complex
Synonym: Troponin [Chemical/Ingredient]
Synonym: Troponin complex
Synonym: Troponin, NOS
Synonym: Troponins
Synonym: troponin
Synonym: troponins
Tree Number: T6.5.3.9
database_cross_reference: CHV:0000012601
database_cross_reference: CSP:2446-8300
database_cross_reference: FMA:62338
database_cross_reference: MSH:D014336
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169462
database_cross_reference: RCD:Xa9wW
database_cross_reference: SNMI:F-62500
database_cross_reference: SNOMEDCT_US:102680009
database_cross_reference: UWDA:62338

Troponin C
type: Class
subclass of: Troponin
MCID: MC00039949
PMOID: PMO:00018868
Subclass_of: Troponin
Synonym: Calcium-binding troponin subunit
Synonym: Clacium-binding troponin subunit
Synonym: TnC
Synonym: Troponin C (substance)
Synonym: Troponin C [Chemical/Ingredient]
Synonym: Troponin-C
Synonym: calcium binding troponin C
Synonym: troponin c
Synonym: troponin c (TnC)
Tree Number: T6.5.3.9.1
database_cross_reference: CHV:0000014995
database_cross_reference: CSP:2446-8300
database_cross_reference: FMA:67901
database_cross_reference: MSH:D019209
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169578
database_cross_reference: SNMI:F-62501
database_cross_reference: SNOMEDCT_US:102681008
database_cross_reference: UWDA:67901

Troponin I
type: Class
subclass of: Troponin
MCID: MC00039950
PMOID: PMO:00018869
Subclass_of: Troponin
Synonym: Inhibitory troponin subunit
Synonym: TnI
Synonym: Troponin I (substance)
Synonym: Troponin I [Chemical/Ingredient]
Synonym: Troponin-I
Synonym: inhibitory troponin I
Synonym: tni
Synonym: troponin i
Synonym: troponin-i
Tree Number: T6.5.3.9.2
database_cross_reference: CHV:0000014996
database_cross_reference: CSP:2446-8300
database_cross_reference: FMA:62340
database_cross_reference: LCH_NW:sh2011005434
database_cross_reference: MSH:D019210
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17343
database_cross_reference: NDFRT:N0000169463
database_cross_reference: RCD:X80QX
database_cross_reference: SNMI:F-62503
database_cross_reference: SNOMEDCT_US:102683006
database_cross_reference: UWDA:62340

Troponin T
type: Class
subclass of: Troponin
MCID: MC00039951
PMOID: PMO:00018870
Subclass_of: Troponin
Synonym: TNT
Synonym: TnT
Synonym: Tropomyosin-binding troponin
Synonym: Tropomyosin-binding troponin subunit
Synonym: Troponin T (substance)
Synonym: Troponin T [Chemical/Ingredient]
Synonym: Troponin-T
Synonym: t troponin
Synonym: tnt
Synonym: tnts
Tree Number: T6.5.3.9.3
database_cross_reference: CHV:0000014997
database_cross_reference: CSP:2446-8300
database_cross_reference: DRUGBANK:DB01676
database_cross_reference: FMA:67900
database_cross_reference: MSH:D020107
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38041
database_cross_reference: NDFRT:N0000169464
database_cross_reference: RCD:X80QY
database_cross_reference: SNMI:F-62502
database_cross_reference: SNOMEDCT_US:102682001
database_cross_reference: UWDA:67900

Cortactin
type: Class
subclass of: PMO:00023655
MCID: MC00069595
PMOID: PMO:00018883
Subclass_of: Phosphoproteins
Synonym: Cortactin [Chemical/Ingredient]
Synonym: cortactin
Tree Number: T6.10.3.40.19
database_cross_reference: CSP:4000-0105
database_cross_reference: MSH:D051356
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170443

Microtubule Proteins
type: Class
subclass of: Biopolymers
subclass of: PMO:00022569
MCID: MC00008296
PMOID: PMO:00018887
Subclass_of: Biopolymers
Subclass_of: Cytoskeletal Proteins
Synonym: Microtubule Proteins [Chemical/Ingredient]
Synonym: Proteins, Microtubule
Synonym: microtubule proteins
Tree Number: T6.10.3.16.4
Tree Number: T6.5.2.3.9
database_cross_reference: AOD:0000020319
database_cross_reference: MSH:D008868
database_cross_reference: NDFRT:N0000169477

Tubulin
type: Class
subclass of: PMO:00023612
MCID: MC00013220
PMOID: PMO:00018888
Subclass_of: Nerve Tissue Proteins
Synonym: Tubulin (substance)
Synonym: Tubulin [Chemical/Ingredient]
Synonym: Tubulins
Synonym: tubulin
Tree Number: T6.10.3.35.14
database_cross_reference: AOD:0000020320
database_cross_reference: CHV:0000012653
database_cross_reference: CSP:2446-8400
database_cross_reference: FMA:67116
database_cross_reference: LCH_NW:sh89000902
database_cross_reference: MSH:D014404
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17219
database_cross_reference: NCI_NCI-GLOSS:CDR0000597173
database_cross_reference: NDFRT:N0000169479
database_cross_reference: SNM:F-13140
database_cross_reference: SNMI:F-62940
database_cross_reference: SNOMEDCT_US:59268003
database_cross_reference: UWDA:67116

Pectins
type: Class
subclass of: Biopolymers
subclass of: PMO:00020992
MCID: MC00009778
PMOID: PMO:00018889
Subclass_of: Biopolymers
Subclass_of: Polysaccharides
Synonym: Pectins [Chemical/Ingredient]
Synonym: pectins
Tree Number: T6.5.2.3.10
Tree Number: T6.8.7.11
database_cross_reference: CHV:0000009380
database_cross_reference: MSH:D010368
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007675

Resins, Plant
type: Class
subclass of: Biopolymers
subclass of: PMO:00024202
PMOID: PMO:00018890
Subclass_of: Biopolymers
Subclass_of: Plant Exudates
Tree Number: T6.12.2.6.3
Tree Number: T6.5.2.3.11

Reticulin
type: Class
subclass of: Biopolymers
subclass of: PMO:00023715
MCID: MC00011296
PMOID: PMO:00018895
Subclass_of: Biopolymers
Subclass_of: Scleroproteins
Synonym: Fiber, Reticular
Synonym: Fiber, Reticulin
Synonym: Fibers, Reticular
Synonym: Fibers, Reticulin
Synonym: Fibril, Reticular
Synonym: Fibril, Reticulin
Synonym: Fibrils, Reticular
Synonym: Fibrils, Reticulin
Synonym: Reticular Fiber
Synonym: Reticular Fibers
Tree Number: T6.10.3.51.3
Tree Number: T6.5.2.3.12
database_cross_reference: AOD:0000020323
database_cross_reference: CHV:0000010786
database_cross_reference: FMA:61748
database_cross_reference: LNC:LP15850-8
database_cross_reference: LNC:MTHU013889
database_cross_reference: MSH:D012155
database_cross_reference: NCI:C33468
database_cross_reference: NDFRT:N0000168660
database_cross_reference: SNM:F-13090
database_cross_reference: SNMI:F-62890
database_cross_reference: SNOMEDCT_US:80494008
database_cross_reference: UWDA:61748

Tannins
type: Class
subclass of: Biopolymers
MCID: MC00012552
PMOID: PMO:00018896
Subclass_of: Biopolymers
Synonym: 4Jointz
Synonym: Acid, Tannic
Synonym: Acids, Tannic
Synonym: Extrait De Fraises
Synonym: Gallotannin
Synonym: Germa Tan
Synonym: Opium Camphre Tanin Tab
Synonym: Outgro Liquid
Synonym: TANNIC ACID
Synonym: Tannic Acid
Tree Number: T6.5.2.3.13
database_cross_reference: AOD:0000019762
database_cross_reference: AOD:0000019764
database_cross_reference: CHV:0000012030
database_cross_reference: CHV:0000012031
database_cross_reference: CSP:2341-7982
database_cross_reference: DRUGBANK:DB09372
database_cross_reference: LCH:U004579
database_cross_reference: LCH_NW:sh85132335
database_cross_reference: LNC:LP19618-5
database_cross_reference: LNC:MTHU009346
database_cross_reference: MEDCIN:40715
database_cross_reference: MMSL:7800
database_cross_reference: MMSL:80867
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D013634
database_cross_reference: MTH:U002281
database_cross_reference: MTHSPL:28F9E0DJY6
database_cross_reference: NCI:C66579
database_cross_reference: NCI_FDA:28F9E0DJY6
database_cross_reference: NDDF:001938
database_cross_reference: NDFRT:N0000007755
database_cross_reference: NDFRT:N0000146849
database_cross_reference: RCD:X79Cz
database_cross_reference: RXNORM:10328
database_cross_reference: SNM:E-8046
database_cross_reference: SNMI:C-A7080
database_cross_reference: SNOMEDCT_US:41412001
database_cross_reference: VANDF:4018527

Silk
type: Class
subclass of: Biopolymers
subclass of: PMO:00023933
MCID: MC00037742
PMOID: PMO:00018897
Subclass_of: Arthropod Proteins
Subclass_of: Biopolymers
Synonym: Bombyx mori fiber
Synonym: SILK
Synonym: Silk (substance)
Synonym: Silk [Chemical/Ingredient]
Synonym: Stylus Sericeus
Synonym: silk
Synonym: silk allergenic extract
Tree Number: T6.10.3.99.4
Tree Number: T6.5.2.3.14
database_cross_reference: CHV:0000014809
database_cross_reference: DRUGBANK:DB10609
database_cross_reference: LCH_NW:sh85122543
database_cross_reference: MSH:D047011
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C79671
database_cross_reference: NCI_FDA:048
database_cross_reference: NDFRT:N0000006238
database_cross_reference: NDFRT:N0000022532
database_cross_reference: SNOMEDCT_US:412156001
database_cross_reference: VANDF:4019245

Plant Gums
type: Class
subclass of: Biopolymers
subclass of: PMO:00020992
subclass of: PMO:00024202
PMOID: PMO:00018900
Subclass_of: Biopolymers
Subclass_of: Plant Exudates
Subclass_of: Polysaccharides
Tree Number: T6.12.2.6.4
Tree Number: T6.5.2.3.15
Tree Number: T6.8.7.17

Chewing Gum
type: Class
subclass of: Plant Gums
MCID: MC00448307
PMOID: PMO:00018901
Subclass_of: Plant Gums
Synonym: Chewing Gum Dosage Form
Synonym: Chewing Gum Dose Form
Synonym: Chewing Gum [Dose Form]
Synonym: Chewing gum
Synonym: GUM CHEWING
Synonym: GUM, CHEWING
Synonym: Gum, Chewing
Synonym: Gum, chewing
Synonym: Oral gum
Synonym: Oral gum (product)
Tree Number: T6.8.7.17.1
database_cross_reference: CHV:0000056912
database_cross_reference: LCH:U000943
database_cross_reference: LCH_NW:sh85023185
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C42894
database_cross_reference: NCI_CDISC:C42894
database_cross_reference: NCI_FDA:085
database_cross_reference: NCI_FDA:C42894
database_cross_reference: NCI_NCPDP:C42894
database_cross_reference: NDFRT:N0000135692
database_cross_reference: RXNORM:402499
database_cross_reference: SNOMEDCT_US:385063000

Gum Arabic
type: Class
subclass of: Plant Gums
MCID: MC00513675
PMOID: PMO:00018903
Subclass_of: Plant Gums
Synonym: Acacia
Synonym: Acacia Pollen
Synonym: Arabic Gum
Synonym: Gum arabic
Synonym: Gum arabic antigen
Tree Number: T6.8.7.17.2
database_cross_reference: DRUGBANK:DB10451
database_cross_reference: LNC:LP17444-8
database_cross_reference: MTH:NOCODE

Karaya Gum
type: Class
subclass of: Plant Gums
MCID: MC01077136
PMOID: PMO:00018904
Subclass_of: Plant Gums
Synonym: Karaya gum
Tree Number: T6.8.7.17.3
database_cross_reference: DRUGBANK:DB10535

Tragacanth
type: Class
subclass of: Plant Gums
MCID: MC00012967
PMOID: PMO:00018905
Subclass_of: Plant Gums
Synonym: Gum Tragacanth
Synonym: Gum tragacanth
Synonym: TRAGACANTH
Synonym: Tragacanth (product)
Synonym: Tragacanth (substance)
Synonym: Tragacanth Gum
Synonym: Tragacanth [Chemical/Ingredient]
Synonym: Tragacanth, Gum
Synonym: tragacanth
Tree Number: T6.8.7.17.4
database_cross_reference: CHV:0000012437
database_cross_reference: DRUGBANK:DB10667
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D014144
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2944357O2O
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C84223
database_cross_reference: NCI_FDA:2944357O2O
database_cross_reference: NDDF:002522
database_cross_reference: NDFRT:N0000006876
database_cross_reference: NDFRT:N0000022533
database_cross_reference: RXNORM:1368197
database_cross_reference: SNM:E-8072
database_cross_reference: SNMI:C-93072
database_cross_reference: SNOMEDCT_US:421065009
database_cross_reference: SNOMEDCT_US:68524009
database_cross_reference: VANDF:4019246

Polyhydroxyalkanoates
type: Class
subclass of: Biopolymers
subclass of: Polyesters
subclass of: PMO:00021062
MCID: MC00628819
PMOID: PMO:00018906
Subclass_of: Biopolymers
Subclass_of: Lipids
Subclass_of: Polyesters
Synonym: Polyhydroxyalkanoates [Chemical/Ingredient]
Tree Number: T6.5.2.10.5
Tree Number: T6.5.2.3.16
Tree Number: T6.9.14
database_cross_reference: MSH:D054813
database_cross_reference: NDFRT:N0000178804

Plant Mucilage
type: Class
subclass of: Biopolymers
subclass of: PMO:00020992
PMOID: PMO:00018907
Subclass_of: Biopolymers
Subclass_of: Polysaccharides
Tree Number: T6.14.9.1.5
Tree Number: T6.5.2.3.17
Tree Number: T6.8.7.18

Fluorocarbon Polymers
type: Class
subclass of: Polymers
MCID: MC00005199
PMOID: PMO:00018908
Subclass_of: Polymers
Synonym: Fluorinated Polymers
Synonym: Fluorocarbon Polymers [Chemical/Ingredient]
Synonym: Polymers, Fluorinated
Synonym: Polymers, Fluorocarbon
Synonym: fluorocarbon polymer
Tree Number: T6.14.9.4
Tree Number: T6.5.2.6
database_cross_reference: CSP:2348-9768
database_cross_reference: MSH:D005465
database_cross_reference: NDFRT:N0000171535

Polytetrafluoroethylene
type: Class
subclass of: Fluorocarbon Polymers
MCID: MC00010474
PMOID: PMO:00018909
Subclass_of: Fluorocarbon Polymers
Synonym: Ethene, tetrafluoro-, homopolymer
Synonym: FEP
Synonym: POLYTETRAFLUOROETHYLENE
Synonym: PTFE
Synonym: PTFE (polytetrafluoroethylene)
Synonym: PTFE - Polytetrafluoroethylene
Synonym: Paratetrafluoroethylene
Synonym: Paratetrafluoroethylene (substance)
Synonym: Politef
Synonym: Polytef
Tree Number: T6.14.9.4.1
Tree Number: T6.5.2.6.1
database_cross_reference: CHV:0000009947
database_cross_reference: CSP:2348-9768
database_cross_reference: LCH_NW:sh86000451
database_cross_reference: MSH:D011138
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:E1NC1JVS3O
database_cross_reference: NDFRT:N0000171536
database_cross_reference: RCD:X79XM
database_cross_reference: RXNORM:1358182
database_cross_reference: SNMI:C-2A560
database_cross_reference: SNOMEDCT_US:256640005
database_cross_reference: SNOMEDCT_US:87427005

Plastics
type: Class
subclass of: Polymers
MCID: MC00010305
PMOID: PMO:00018911
Subclass_of: Polymers
Synonym: Plastic
Synonym: Plastic (substance)
Synonym: Plastic compound
Synonym: Plastic compound, NOS
Synonym: Plastic substance
Synonym: Plastic substance, NOS
Synonym: Plastic, NOS
Synonym: Plastics [Chemical/Ingredient]
Synonym: plastic
Synonym: plastics
Tree Number: T6.14.9.6
Tree Number: T6.5.2.8
database_cross_reference: CHV:0000009827
database_cross_reference: CSP:2348-9293
database_cross_reference: LCH:U003715
database_cross_reference: LCH_NW:sh85103153
database_cross_reference: MSH:D010969
database_cross_reference: NCI:C86968
database_cross_reference: NDFRT:N0000008071
database_cross_reference: RCD:X90Fc
database_cross_reference: SNM:E-5402
database_cross_reference: SNMI:C-2A000
database_cross_reference: SNOMEDCT_US:61088005

Nylons
type: Class
subclass of: Plastics
MCID: MC00009076
PMOID: PMO:00018912
Subclass_of: Plastics
Synonym: NYLON
Synonym: Nylon
Synonym: Nylon (substance)
Synonym: Nylon fiber
Synonym: Nylon fibre
Synonym: Nylon material
Synonym: Nylons [Chemical/Ingredient]
Synonym: Polyamide
Synonym: Polyamides
Synonym: nylon
Tree Number: T6.14.9.6.1
Tree Number: T6.5.2.8.1
database_cross_reference: CHV:0000008855
database_cross_reference: CSP:2348-9293
database_cross_reference: LCH:U003309
database_cross_reference: LCH_NW:sh85093523
database_cross_reference: MSH:D009757
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:011190
database_cross_reference: NDFRT:N0000006678
database_cross_reference: NDFRT:N0000022529
database_cross_reference: RCD:XaCuy
database_cross_reference: SNMI:C-2A030
database_cross_reference: SNOMEDCT_US:55700001
database_cross_reference: VANDF:4019242

Resins, Synthetic
type: Class
subclass of: Plastics
subclass of: PMO:00024407
MCID: MC00011270
PMOID: PMO:00018914
Subclass_of: Dental Materials
Subclass_of: Plastics
Synonym: RESINS SYN
Synonym: Resin, Synthetic
Synonym: Resins, Synthetic [Chemical/Ingredient]
Synonym: Synthetic Resin
Synonym: Synthetic Resins
Tree Number: T6.14.5.7
Tree Number: T6.14.9.6.7
Tree Number: T6.5.2.8.7
database_cross_reference: MSH:D012117
database_cross_reference: NDFRT:N0000008160

Bone Cements
type: Class
subclass of: PMO:00024401
MCID: MC00001859
PMOID: PMO:00018916
Subclass_of: Biomedical and Dental Materials
Synonym: Bone Cement
Synonym: Bone Cements [Chemical/Ingredient]
Synonym: Bone Glue
Synonym: Bone Glues
Synonym: Bone Paste
Synonym: Bone Pastes
Synonym: Bone cement
Synonym: Bone cement (substance)
Synonym: Bone cement, device
Synonym: Bone cement, device (substance)
Tree Number: T6.16.3.4.3
database_cross_reference: CHV:0000002061
database_cross_reference: LCH:U000636
database_cross_reference: LCH_NW:sh85015518
database_cross_reference: MSH:D001843
database_cross_reference: NDDF:016196
database_cross_reference: NDFRT:N0000011368
database_cross_reference: RCD:x03jQ
database_cross_reference: SNMI:A-12130
database_cross_reference: SNOMEDCT_US:356497001
database_cross_reference: SNOMEDCT_US:408004005
database_cross_reference: SNOMEDCT_US:6043006
database_cross_reference: UMD:12-830

Composite Resins
type: Class
subclass of: Resins, Synthetic
MCID: MC00003162
PMOID: PMO:00018917
Subclass_of: Resins, Synthetic
Synonym: Composite Resins [Chemical/Ingredient]
Synonym: Resins, Composite
Synonym: composite resin
Synonym: composite resins
Synonym: composites resin
Synonym: composites resins
Synonym: resin composite
Tree Number: T6.14.5.7.1
database_cross_reference: CHV:0000003249
database_cross_reference: CSP:0831-8436
database_cross_reference: MSH:D003188
database_cross_reference: NDFRT:N0000171541

Compomers
type: Class
subclass of: PMO:00024411
MCID: MC00259220
PMOID: PMO:00018918
Subclass_of: Dental Cements
Synonym: Compomers [Chemical/Ingredient]
Synonym: Composite Resins, Polyacid Modified
Synonym: Composite Resins, Polyacid-Modified
Synonym: Polyacid Modified Composite Resins
Synonym: Polyacid-Modified Composite Resins
Synonym: Resins, Polyacid-Modified Composite
Synonym: compomer
Synonym: compomers
Tree Number: T6.14.5.3.8
database_cross_reference: CHV:0000048535
database_cross_reference: MSH:D020770
database_cross_reference: NDFRT:N0000171543

Resin Cements
type: Class
subclass of: PMO:00024411
MCID: MC00133351
PMOID: PMO:00018920
Subclass_of: Dental Cements
Synonym: Cement, Resin
Synonym: Cements, Resin
Synonym: Resin Cement
Synonym: Resin Cements [Chemical/Ingredient]
Synonym: resin cement
Synonym: resin cements
Tree Number: T6.14.5.3.7
database_cross_reference: CHV:0000031795
database_cross_reference: MSH:D019279
database_cross_reference: NDFRT:N0000171544

Biodegradable Plastics
type: Class
subclass of: Plastics
PMOID: PMO:00018921
Subclass_of: Plastics
Tree Number: T6.14.9.6.8
Tree Number: T6.5.2.8.8

Polyesters
type: Class
subclass of: Polymers
MCID: MC00010413
PMOID: PMO:00018922
Subclass_of: Polymers
Synonym: Polyester
Synonym: Polyester (substance)
Synonym: Polyester, NOS
Synonym: Polyesters [Chemical/Ingredient]
Synonym: polyester
Tree Number: T6.14.9.8
Tree Number: T6.5.2.10
database_cross_reference: CHV:0000009913
database_cross_reference: LCH:U003756
database_cross_reference: LCH_NW:sh85104622
database_cross_reference: MSH:D011091
database_cross_reference: NDDF:010515
database_cross_reference: NDFRT:N0000011413
database_cross_reference: SNMI:C-2A040
database_cross_reference: SNOMEDCT_US:8204009

Polyethylene Terephthalates
type: Class
subclass of: Polyesters
PMOID: PMO:00018923
Subclass_of: Polyesters
Tree Number: T6.14.9.8.1
Tree Number: T6.5.2.10.1

Polyglactin 910
type: Class
subclass of: Polyesters
MCID: MC00010424
PMOID: PMO:00018924
Subclass_of: Polyesters
Synonym: Polygalactin 910
Synonym: Polyglactin 910 [Chemical/Ingredient]
Synonym: Propanoic acid, 2-hydroxy-, polymer with hydroxyacetic acid
Tree Number: T6.14.9.8.2
Tree Number: T6.5.2.10.2
database_cross_reference: MSH:D011098
database_cross_reference: NDFRT:N0000011412

Polyglycolic Acid
type: Class
subclass of: Polyesters
MCID: MC00010427
PMOID: PMO:00018925
Subclass_of: Polyesters
Synonym: POLYGLYCOLIC ACID
Synonym: Poly(oxy(1-oxo-1,2-ethanediyl))
Synonym: Polyglycolic Acid [Chemical/Ingredient]
Synonym: Polyglycolide
Tree Number: T6.14.9.8.3
Tree Number: T6.5.2.10.3
database_cross_reference: MSH:D011100
database_cross_reference: MTHSPL:H1IL6F7KB8
database_cross_reference: NDFRT:N0000171519

Polydioxanone
type: Class
subclass of: Polyesters
subclass of: PMO:00024402
MCID: MC00043229
PMOID: PMO:00018926
Subclass_of: Biocompatible Materials
Subclass_of: Polyesters
Synonym: Poly(oxy(1-oxo-1,2-ethanediyl)oxy-1,2-ethanediyl)
Synonym: Polydioxanone [Chemical/Ingredient]
Synonym: Polydioxanones
Tree Number: T6.14.2.1
Tree Number: T6.14.9.8.4
Tree Number: T6.5.2.10.4
database_cross_reference: MSH:D016687
database_cross_reference: NDFRT:N0000171517

Certolizumab Pegol
type: Class
subclass of: Polyethylene Glycols
MCID: MC00620758
PMOID: PMO:00018927
Subclass_of: Polyethylene Glycols
Synonym: CERTOLIZUMAB
Synonym: CERTOLIZUMAB PEGOL
Synonym: CZP
Synonym: Certolizumab
Synonym: Certolizumab Pegol [Chemical/Ingredient]
Synonym: Certolizumab Pegols
Synonym: Certolizumab pegol
Synonym: Certolizumab pegol (product)
Synonym: Certolizumab pegol (substance)
Synonym: Pegol, Certolizumab
Tree Number: T6.5.2.11.1
database_cross_reference: ATC:L04AB05
database_cross_reference: DRUGBANK:DB08904
database_cross_reference: MEDCIN:303945
database_cross_reference: MMSL:25282
database_cross_reference: MMSL:d07134
database_cross_reference: MSH:D000068582
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:UMD07X179E
database_cross_reference: NCI:C80972
database_cross_reference: NCI:C97947
database_cross_reference: NCI_FDA:G6ADW90R16
database_cross_reference: NCI_FDA:UMD07X179E
database_cross_reference: NDDF:012650
database_cross_reference: NDFRT:N0000176156
database_cross_reference: NDFRT:N0000178499
database_cross_reference: NDFRT:N0000191964
database_cross_reference: RXNORM:709271
database_cross_reference: SNOMEDCT_US:430306004
database_cross_reference: SNOMEDCT_US:430307008
database_cross_reference: USPMG:MTHU003327
database_cross_reference: VANDF:4027433
database_cross_reference: VANDF:4028807

Polygeline
type: Class
subclass of: Polymers
subclass of: PMO:00021328
MCID: MC00010422
PMOID: PMO:00018928
Subclass_of: Peptides
Subclass_of: Polymers
Synonym: Polygeline (product)
Synonym: Polygeline (substance)
Synonym: Polygeline [Chemical/Ingredient]
Synonym: Polygelines
Synonym: polygeline
Tree Number: T6.10.2.17
Tree Number: T6.14.9.10
Tree Number: T6.5.2.12
database_cross_reference: MSH:D011097
database_cross_reference: NDDF:004103
database_cross_reference: NDFRT:N0000171524
database_cross_reference: RXNORM:8521
database_cross_reference: SNOMEDCT_US:395836000
database_cross_reference: SNOMEDCT_US:420778005

Silicone Elastomers
type: Class
subclass of: PMO:00024438
MCID: MC00011863
PMOID: PMO:00018929
Subclass_of: Elastomers
Synonym: Elastomers, Silicone
Synonym: Elastomers, Silicone Rubber
Synonym: Rubber Silicone
Synonym: Silicone Elastomer
Synonym: Silicone Elastomers [Chemical/Ingredient]
Synonym: Silicone Rubber
Synonym: Silicone rubber
Synonym: silicone elastomer
Synonym: silicone rubber
Tree Number: T6.14.9.14.5
database_cross_reference: CHV:0000011345
database_cross_reference: CSP:2349-0711
database_cross_reference: LCH:U006144
database_cross_reference: LCH_NW:sh85122533
database_cross_reference: MSH:D012826
database_cross_reference: NDFRT:N0000171526
database_cross_reference: UMD:11-394

Dendrimers
type: Class
subclass of: Polymers
MCID: MC00540133
PMOID: PMO:00018930
Subclass_of: Polymers
Synonym: Cascade Molecule
Synonym: Compound, Dendritic
Synonym: Dendrimer
Synonym: Dendrimers [Chemical/Ingredient]
Synonym: Dendritic Compound
Synonym: Dendritic Compounds
Synonym: Dendritic Polymer
Synonym: Dendritic Polymers
Synonym: Dendrons
Synonym: Polymer, Dendritic
Tree Number: T6.5.2.17
database_cross_reference: LCH_NW:sh97003940
database_cross_reference: MSH:D050091
database_cross_reference: NCI:C62363
database_cross_reference: NDFRT:N0000167479

Multiprotein Complexes
type: Class
subclass of: Macromolecular Substances
MCID: MC00258663
PMOID: PMO:00018931
Subclass_of: Macromolecular Substances
Synonym: Complexes, Macromolecular Protein
Synonym: Complexes, Multiprotein
Synonym: Macromolecular Protein Complexes
Synonym: Multiprotein Complexes [Chemical/Ingredient]
Synonym: Protein Complexes, Macromolecular
Tree Number: T6.5.3
database_cross_reference: MSH:D046912
database_cross_reference: NDFRT:N0000167472

Protein Translocation Systems
type: Class
subclass of: Multiprotein Complexes
MCID: MC01007835
PMOID: PMO:00018932
Subclass_of: Multiprotein Complexes
Synonym: Protein Translocation Systems [Chemical/Ingredient]
Synonym: Systems, Protein Translocation
Synonym: Translocation Systems, Protein
Tree Number: T6.5.3.1
database_cross_reference: MSH:D000069284
database_cross_reference: NDFRT:N0000192013

Twin-Arginine-Translocation System
type: Class
subclass of: Protein Translocation Systems
MCID: MC01007810
PMOID: PMO:00018933
Subclass_of: Protein Translocation Systems
Synonym: Secretion Systems, TAT
Synonym: System, Twin-Arginine-Transport
Synonym: Systems, TAT Secretion
Synonym: Systems, Twin-Arginine-Translocation
Synonym: TAT Secretion Systems
Synonym: Twin Arginine Translocation System
Synonym: Twin Arginine Translocation Systems
Synonym: Twin Arginine Transport System
Synonym: Twin-Arginine-Translocation System [Chemical/Ingredient]
Synonym: Twin-Arginine-Translocation Systems
Tree Number: T6.5.3.1.1
database_cross_reference: MSH:D000069294
database_cross_reference: NDFRT:N0000192002

SEC Translocation Channels
type: Class
subclass of: Protein Translocation Systems
MCID: MC01054875
PMOID: PMO:00018934
Subclass_of: Protein Translocation Systems
Synonym: Channels, SEC Translocation
Synonym: Complexes, SEC
Synonym: SEC Complexes
Synonym: SEC Translocase
Synonym: SEC Translocation Channels [Chemical/Ingredient]
Synonym: SEC Translocons
Synonym: Sec Protein Translocation Systems
Synonym: Translocase, SEC
Synonym: Translocation Channels, SEC
Synonym: Translocons, SEC
Tree Number: T6.5.3.1.2
database_cross_reference: MSH:D000069816
database_cross_reference: NDFRT:N0000193166

Bacterial Secretion Systems
type: Class
subclass of: Protein Translocation Systems
MCID: MC00798026
PMOID: PMO:00018935
Subclass_of: Protein Translocation Systems
Synonym: Bacterial Secretion System
Synonym: Bacterial Secretion Systems [Chemical/Ingredient]
Synonym: Secretion System, Bacterial
Synonym: Secretion Systems, Bacterial
Synonym: System, Bacterial Secretion
Synonym: Systems, Bacterial Secretion
Tree Number: T6.5.3.1.3
database_cross_reference: MSH:D058947
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000191978

Dynactin Complex
type: Class
subclass of: Multiprotein Complexes
MCID: MC00394800
PMOID: PMO:00018943
Subclass_of: Multiprotein Complexes
Synonym: Dynactin Complex [Chemical/Ingredient]
Synonym: Dynactins
Tree Number: T6.5.3.2
database_cross_reference: MSH:D000072159
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000193002

COP9 Signalosome Complex
type: Class
subclass of: Multiprotein Complexes
MCID: MC00086822
PMOID: PMO:00018944
Subclass_of: Multiprotein Complexes
Synonym: COP9 Signalosome (CSN)
Synonym: COP9 signalosome complex
Tree Number: T6.5.3.3
database_cross_reference: MSH:C088436

Mechanistic Target of Rapamycin Complex 1
type: Class
subclass of: Multiprotein Complexes
MCID: MC00495213
PMOID: PMO:00018945
Subclass_of: Multiprotein Complexes
Synonym: FK506 binding protein 12-rapamycin associated protein 2
Synonym: FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1
Synonym: FKBP-rapamycin associated protein
Synonym: FKBP12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1
Synonym: FKBP12-rapamycin complex-associated protein 1
Synonym: FLJ44809
Synonym: FRAP
Synonym: FRAP1
Synonym: FRAP2
Synonym: MAMMALIAN TARGET OF RAPAMYCIN
Tree Number: T6.5.3.4
database_cross_reference: HGNC:HGNC:3942
database_cross_reference: MTH:NOCODE
database_cross_reference: NCBI_Gene:2475
database_cross_reference: NCI:C38928
database_cross_reference: OMIM:601231

Regulatory-Associated Protein of mTOR
type: Class
subclass of: Mechanistic Target of Rapamycin Complex 1
PMOID: PMO:00018946
Subclass_of: Mechanistic Target of Rapamycin Complex 1
Tree Number: T6.5.3.4.1

MTOR Associated Protein, LST8 Homolog
type: Class
subclass of: Mechanistic Target of Rapamycin Complex 1
MCID: MC00735161
PMOID: PMO:00018947
Subclass_of: Mechanistic Target of Rapamycin Complex 1
Synonym: G PROTEIN BETA SUBUNIT-LIKE PROTEIN
Synonym: G protein beta subunit like
Synonym: G-BETA-LIKE PROTEIN
Synonym: GBL
Synonym: GbetaL
Synonym: LST8
Synonym: LST8, S. CEREVISIAE, HOMOLOG OF
Synonym: Lst8
Synonym: MLST8
Synonym: MLST8 gene
Tree Number: T6.5.3.4.2
database_cross_reference: HGNC:HGNC:24825
database_cross_reference: MTH:NOCODE
database_cross_reference: NCBI_Gene:107181291
database_cross_reference: NCBI_Gene:64223
database_cross_reference: OMIM:612190

Mechanistic Target of Rapamycin Complex 2
type: Class
subclass of: Multiprotein Complexes
MCID: MC00495213
PMOID: PMO:00018948
Subclass_of: Multiprotein Complexes
Synonym: FK506 binding protein 12-rapamycin associated protein 2
Synonym: FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1
Synonym: FKBP-rapamycin associated protein
Synonym: FKBP12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1
Synonym: FKBP12-rapamycin complex-associated protein 1
Synonym: FLJ44809
Synonym: FRAP
Synonym: FRAP1
Synonym: FRAP2
Synonym: MAMMALIAN TARGET OF RAPAMYCIN
Tree Number: T6.5.3.5
database_cross_reference: HGNC:HGNC:3942
database_cross_reference: MTH:NOCODE
database_cross_reference: NCBI_Gene:2475
database_cross_reference: NCI:C38928
database_cross_reference: OMIM:601231

Rapamycin-Insensitive Companion of mTOR Protein
type: Class
subclass of: Mechanistic Target of Rapamycin Complex 2
PMOID: PMO:00018949
Subclass_of: Mechanistic Target of Rapamycin Complex 2
Tree Number: T6.5.3.5.1

Amyloid
type: Class
subclass of: Multiprotein Complexes
subclass of: PMO:00021871
MCID: MC00000832
PMOID: PMO:00018950
Subclass_of: Multiprotein Complexes
Subclass_of: Proteins
Synonym: Amyloid Substance
Synonym: Amyloid [Chemical/Ingredient]
Synonym: Amyloid, NOS
Synonym: Substance, Amyloid
Synonym: amyloid
Synonym: amyloids
Tree Number: T6.10.3.8
Tree Number: T6.5.3.6
database_cross_reference: AOD:0000020472
database_cross_reference: CHV:0000001068
database_cross_reference: LCH_NW:sh92004711
database_cross_reference: LNC:LP31745-0
database_cross_reference: MSH:D000682
database_cross_reference: MTH:U001687
database_cross_reference: NDFRT:N0000169151
database_cross_reference: SNMI:M-55100

Lactose Synthase
type: Class
subclass of: Multiprotein Complexes
MCID: MC00007342
PMOID: PMO:00018951
Subclass_of: Multiprotein Complexes
Synonym: Lactose Synthase [Chemical/Ingredient]
Synonym: Lactose Synthetase
Synonym: Lactose synthase
Synonym: Lactose synthase (substance)
Synonym: Synthase, Lactose
Synonym: Synthetase, Lactose
Synonym: UDPgalactose-glucose galactosyltransferase
Synonym: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase
Synonym: lactose synthase
Tree Number: T6.5.3.7
database_cross_reference: CSP:4000-0200
database_cross_reference: MSH:D007788
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168331
database_cross_reference: SNMI:F-687C0
database_cross_reference: SNOMEDCT_US:32685004

Multienzyme Complexes
type: Class
subclass of: Multiprotein Complexes
subclass of: Enzymes
MCID: MC00008466
PMOID: PMO:00018952
Subclass_of: Enzymes
Subclass_of: Multiprotein Complexes
Synonym: Complexes, Multienzyme
Synonym: Multienzyme Complexes [Chemical/Ingredient]
Synonym: Multienzyme complexes
Synonym: enzyme complex
Synonym: multienzyme complexes
Tree Number: T6.5.3.8
Tree Number: T6.7.4.8
database_cross_reference: AOD:0000018398
database_cross_reference: CSP:1036-0609
database_cross_reference: LCH_NW:sh89006397
database_cross_reference: MSH:D009097
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167736

Electron Transport Complex IV
type: Class
subclass of: Multienzyme Complexes
subclass of: Oxidoreductases
MCID: MC00003496
PMOID: PMO:00018953
Subclass_of: Multienzyme Complexes
Subclass_of: Oxidoreductases
Synonym: CYTOCHROME C OXIDASE
Synonym: Complex IV
Synonym: Cytochrome C Oxidase
Synonym: Cytochrome C oxidase
Synonym: Cytochrome Oxidase
Synonym: Cytochrome c Oxidase
Synonym: Cytochrome c oxidase
Synonym: Cytochrome c oxidase (substance)
Synonym: Cytochrome oxidase
Synonym: Cytochrome-c Oxidase
Tree Number: T6.5.3.8.1
Tree Number: T6.7.4.9.5
database_cross_reference: CHV:0000003574
database_cross_reference: CHV:0000041862
database_cross_reference: CSP:2169-8705
database_cross_reference: LCH:U001252
database_cross_reference: LCH_NW:sh85035231
database_cross_reference: LNC:LP15525-6
database_cross_reference: LNC:MTHU008070
database_cross_reference: MSH:D003576
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26034
database_cross_reference: NDDF:008944
database_cross_reference: NDFRT:N0000169694
database_cross_reference: PSY:12920
database_cross_reference: RCD:X80Ie
database_cross_reference: SNMI:F-67050
database_cross_reference: SNOMEDCT_US:259414009
database_cross_reference: SNOMEDCT_US:43460006

Ketoglutarate Dehydrogenase Complex
type: Class
subclass of: Multienzyme Complexes
MCID: MC00007227
PMOID: PMO:00018954
Subclass_of: Multienzyme Complexes
Synonym: 2 Keto 4 Hydroxyglutarate Dehydrogenase
Synonym: 2 Oxoglutarate Dehydrogenase
Synonym: 2 Oxoglutarate Dehydrogenase Complex
Synonym: 2-Keto-4-Hydroxyglutarate Dehydrogenase
Synonym: 2-Oxoglutarate Dehydrogenase
Synonym: 2-Oxoglutarate Dehydrogenase Complex
Synonym: 2-Oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating)
Synonym: Complex, 2-Oxoglutarate Dehydrogenase
Synonym: Complex, Ketoglutarate Dehydrogenase
Synonym: Complex, alpha-Ketoglutarate Dehydrogenase
Tree Number: T6.5.3.8.2
Tree Number: T6.7.4.8.3
database_cross_reference: CSP:2182-0889
database_cross_reference: MSH:D007655
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167912

Dihydrolipoamide Dehydrogenase
type: Class
subclass of: PMO:00022858
MCID: MC00007593
PMOID: PMO:00018955
Subclass_of: Flavoproteins
Synonym: DIHYDROLIPOAMIDE DEHYDROGENASE
Synonym: Dehydrogenase, Dihydrolipoamide
Synonym: Dehydrogenase, Dihydrolipoyl
Synonym: Dehydrogenase, Lipoamide
Synonym: Dehydrogenase, Lipoic Acid
Synonym: Dehydrogenase, Lipoyl
Synonym: Diaphorase
Synonym: Diaphorase (Lipoamide Dehydrogenase)
Synonym: Diaphorase, NAD
Synonym: Diaphorase, NADH
Tree Number: T6.10.3.23.3
database_cross_reference: CHV:0000007455
database_cross_reference: CSP:2179-9847
database_cross_reference: LNC:LP15538-9
database_cross_reference: LNC:MTHU010534
database_cross_reference: MSH:D008058
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169067
database_cross_reference: SNM:F-22400
database_cross_reference: SNMI:F-66FE0
database_cross_reference: SNOMEDCT_US:39383000

Phosphoenolpyruvate Sugar Phosphotransferase System
type: Class
subclass of: Multienzyme Complexes
MCID: MC00010121
PMOID: PMO:00018956
Subclass_of: Multienzyme Complexes
Synonym: PEPPTS
Synonym: Phosphoenolpyruvate Sugar Phosphotransferase System [Chemical/Ingredient]
Tree Number: T6.5.3.8.3
Tree Number: T6.7.4.8.4
database_cross_reference: MSH:D010731
database_cross_reference: NDFRT:N0000168207

Pyruvate Dehydrogenase Complex
type: Class
subclass of: Multienzyme Complexes
MCID: MC00011043
PMOID: PMO:00018957
Subclass_of: Multienzyme Complexes
Synonym: Complex, Pyruvate Dehydrogenase
Synonym: Dehydrogenase Complex, Pyruvate
Synonym: Pyruvate Dehydrogenase Complex [Chemical/Ingredient]
Synonym: Pyruvate dehydrogenase complex
Synonym: pyruvate dehydrogenase complex
Tree Number: T6.5.3.8.4
Tree Number: T6.7.4.8.6
database_cross_reference: AOD:0000018402
database_cross_reference: CHV:0000010471
database_cross_reference: LNC:LP182303-0
database_cross_reference: LNC:MTHU047748
database_cross_reference: MSH:D011768
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167744

Succinate Cytochrome c Oxidoreductase
type: Class
subclass of: Multienzyme Complexes
subclass of: Oxidoreductases
MCID: MC00012337
PMOID: PMO:00018960
Subclass_of: Multienzyme Complexes
Subclass_of: Oxidoreductases
Synonym: Succinate Cytochrome c Oxidoreductase [Chemical/Ingredient]
Synonym: Succinate Cytochrome c Reductase
Synonym: Succinate cytochrome C reductase
Synonym: Succinate cytochrome C reductase (substance)
Synonym: succinate cytochrome C oxidoreductase
Tree Number: T6.5.3.8.5
Tree Number: T6.7.4.9.15
database_cross_reference: AOD:0000018502
database_cross_reference: LNC:LP33250-9
database_cross_reference: LNC:MTHU016503
database_cross_reference: MSH:D013384
database_cross_reference: NDFRT:N0000167842
database_cross_reference: SNOMEDCT_US:708051001

Sucrase-Isomaltase Complex
type: Class
subclass of: Multienzyme Complexes
MCID: MC00012346
PMOID: PMO:00018964
Subclass_of: Multienzyme Complexes
Synonym: Complex, Sucrase Isomaltase
Synonym: Complex, Sucrase-Isomaltase
Synonym: Isomaltase Complex, Sucrase
Synonym: Sucrase Isomaltase Complex
Synonym: Sucrase-Isomaltase Complex [Chemical/Ingredient]
Tree Number: T6.5.3.8.6
Tree Number: T6.7.4.8.7
database_cross_reference: MSH:D013394
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167740

Electron Transport Complex I
type: Class
subclass of: Multienzyme Complexes
MCID: MC00721636
PMOID: PMO:00018965
Subclass_of: Multienzyme Complexes
Synonym: Electron Transport Complex I [Chemical/Ingredient]
Synonym: Respiratory Complex I
Tree Number: T6.5.3.8.7
database_cross_reference: MSH:D042967
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169692

Photosynthetic Reaction Center Complex Proteins
type: Class
subclass of: Multienzyme Complexes
MCID: MC00421681
PMOID: PMO:00018966
Subclass_of: Multienzyme Complexes
Synonym: Photosynthetic Reaction Center Complex Proteins [Chemical/Ingredient]
Tree Number: T6.5.3.8.8
Tree Number: T6.7.4.8.10
database_cross_reference: MSH:D045322
database_cross_reference: NDFRT:N0000170197

Phycocyanin
type: Class
subclass of: PMO:00023657
subclass of: PMO:00024379
MCID: MC00010180
PMOID: PMO:00018971
Subclass_of: Pigments, Biological
Subclass_of: Plant Proteins
Synonym: Phycocyanin (substance)
Synonym: Phycocyanin [Chemical/Ingredient]
Synonym: Phycocyanins, C-
Synonym: phycocyanin
Tree Number: T6.10.3.41.3
Tree Number: T6.13.7.10
database_cross_reference: CSP:2447-5000
database_cross_reference: MSH:D010798
database_cross_reference: NDFRT:N0000171236
database_cross_reference: SNMI:C-30510
database_cross_reference: SNOMEDCT_US:64437001

Phycoerythrin
type: Class
subclass of: PMO:00023657
subclass of: PMO:00024379
MCID: MC00010181
PMOID: PMO:00018972
Subclass_of: Pigments, Biological
Subclass_of: Plant Proteins
Synonym: Phycoerythrin (substance)
Synonym: Phycoerythrin [Chemical/Ingredient]
Synonym: Phycoerythrins, R-
Synonym: phycoerythrin
Tree Number: T6.10.3.41.4
Tree Number: T6.13.7.11
database_cross_reference: CSP:2447-5000
database_cross_reference: MSH:D010799
database_cross_reference: NDFRT:N0000171221
database_cross_reference: SNMI:C-30512
database_cross_reference: SNOMEDCT_US:34101007

Cytochromes b6
type: Class
subclass of: Cytochrome b Group
MCID: MC00382542
PMOID: PMO:00018975
Subclass_of: Cytochrome b Group
Synonym: Cytochrome b6
Synonym: Cytochromes b6 [Chemical/Ingredient]
Synonym: cytochrome b6
Tree Number: T6.7.2.1.3
database_cross_reference: MSH:D045347
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170201

Cytochromes f
type: Class
subclass of: Cytochromes
MCID: MC00024098
PMOID: PMO:00018976
Subclass_of: Cytochromes
Synonym: Cytochrome f
Synonym: Cytochromes f [Chemical/Ingredient]
Synonym: cytochrome f
Tree Number: T6.7.2.6
database_cross_reference: CSP:1418-4617
database_cross_reference: MSH:D045348
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170199

Plastoquinol-Plastocyanin Reductase
type: Class
subclass of: Oxidoreductases
MCID: MC00113412
PMOID: PMO:00018977
Subclass_of: Oxidoreductases
Synonym: Oxidoreductase, Plastoquinol-Plastocyanin
Synonym: Plastoquinol Plastocyanin Oxidoreductase
Synonym: Plastoquinol Plastocyanin Reductase
Synonym: Plastoquinol-Plastocyanin Oxidoreductase
Synonym: Plastoquinol-Plastocyanin Reductase [Chemical/Ingredient]
Synonym: Plastoquinol-plastocyanin reductase
Synonym: Plastoquinol-plastocyanin reductase (substance)
Synonym: Reductase, Plastoquinol-Plastocyanin
Tree Number: T6.7.4.9.21
database_cross_reference: MSH:D050547
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170200
database_cross_reference: SNMI:F-670B0
database_cross_reference: SNOMEDCT_US:686001

Proteasome Endopeptidase Complex
type: Class
subclass of: Multienzyme Complexes
MCID: MC00068114
PMOID: PMO:00018978
Subclass_of: Multienzyme Complexes
Synonym: 20S Catalytic Proteasome
Synonym: 20S Core Proteasome
Synonym: 20S Proteasome
Synonym: 20S Proteosome
Synonym: Complex, Multicatalytic Endopeptidase
Synonym: Complex, Proteasome Endopeptidase
Synonym: Endopeptidase Complex, Multicatalytic
Synonym: Endopeptidase Complex, Proteasome
Synonym: Macropain
Synonym: Macroxyproteinase
Tree Number: T6.5.3.8.9
Tree Number: T6.7.4.8.11
database_cross_reference: CHV:0000021084
database_cross_reference: CSP:4007-0104
database_cross_reference: MSH:D046988
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13314
database_cross_reference: NCI:C13737
database_cross_reference: NDFRT:N0000167743
database_cross_reference: SNOMEDCT_US:130755008

Glycine Decarboxylase Complex
type: Class
subclass of: Multienzyme Complexes
MCID: MC00517228
PMOID: PMO:00018979
Subclass_of: Multienzyme Complexes
Synonym: Decarboxylase Complex, Glycine
Synonym: Glycine Cleavage System Complex
Synonym: Glycine Decarboxylase Complex [Chemical/Ingredient]
Tree Number: T6.5.3.8.10
Tree Number: T6.7.4.8.13
database_cross_reference: MSH:D050959
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167831

Fatty Acid Synthase, Type II
type: Class
subclass of: Multienzyme Complexes
PMOID: PMO:00018983
Subclass_of: Multienzyme Complexes
Tree Number: T6.5.3.8.11
Tree Number: T6.7.4.8.14

Exosome Multienzyme Ribonuclease Complex
type: Class
subclass of: Multienzyme Complexes
MCID: MC00732158
PMOID: PMO:00018984
Subclass_of: Multienzyme Complexes
Synonym: Cytoplasmic Exosome Complex
Synonym: Exosome Complex, Cytoplasmic
Synonym: Exosome Complex, RNA
Synonym: Exosome Multienzyme Ribonuclease Complex [Chemical/Ingredient]
Synonym: Exosome, RNA
Synonym: RNA Exosome
Synonym: RNA Exosome Complex
Synonym: exosome (RNase complex location)
Synonym: exosome (RNase complex)
Synonym: exosome (ribonucleasease complex location)
Tree Number: T6.5.3.8.12
Tree Number: T6.7.4.8.17
database_cross_reference: GO:GO:0000178
database_cross_reference: MSH:D063326
database_cross_reference: NDFRT:N0000185673

Molecular Motor Proteins
type: Class
subclass of: Multiprotein Complexes
MCID: MC00583085
PMOID: PMO:00018985
Subclass_of: Multiprotein Complexes
Synonym: Molecular Motor Proteins [Chemical/Ingredient]
Synonym: Motor Proteins, Molecular
Synonym: Proteins, Molecular Motor
Tree Number: T6.5.3.10
database_cross_reference: MSH:D020409
database_cross_reference: NDFRT:N0000167474

Dystrophin-Associated Protein Complex
type: Class
subclass of: Multiprotein Complexes
MCID: MC00516548
PMOID: PMO:00018986
Subclass_of: Multiprotein Complexes
Synonym: DYSTROPHIN ASSOC PROTEIN COMPLEX
Synonym: Dystrophin Associated Protein Complex
Synonym: Dystrophin-Associated Protein Complex [Chemical/Ingredient]
Tree Number: T6.5.3.11
database_cross_reference: MSH:D049028
database_cross_reference: NDFRT:N0000167475

Apoptosomes
type: Class
subclass of: Multiprotein Complexes
MCID: MC00569290
PMOID: PMO:00018987
Subclass_of: Multiprotein Complexes
Synonym: Apoptosomal Protein Complex
Synonym: Apoptosome
Synonym: Apoptosomes [Chemical/Ingredient]
Synonym: Complex, Apoptosomal Protein
Synonym: Protein Complex, Apoptosomal
Synonym: apoptosome
Tree Number: T6.5.3.12
database_cross_reference: GO:GO:0043293
database_cross_reference: MSH:D053478
database_cross_reference: NDFRT:N0000175108

Endosomal Sorting Complexes Required for Transport
type: Class
subclass of: Multiprotein Complexes
MCID: MC00590550
PMOID: PMO:00018988
Subclass_of: Multiprotein Complexes
Synonym: Complexes, ESCRT
Synonym: ESCRT Complexes
Synonym: ESCRT Machinery
Synonym: Endosomal Sorting Complex Required for Transport
Synonym: Endosomal Sorting Complex Required for Transport Machinery
Synonym: Endosomal Sorting Complexes Required for Transport [Chemical/Ingredient]
Synonym: Machinery, ESCRT
Tree Number: T6.5.3.13
database_cross_reference: MSH:D056827
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000180235

Nedd4 Ubiquitin Protein Ligases
type: Class
subclass of: Endosomal Sorting Complexes Required for Transport
MCID: MC00445198
PMOID: PMO:00018989
Subclass_of: Endosomal Sorting Complexes Required for Transport
Synonym: Nedd4 ubiquitin protein ligases
Synonym: neuronal precursor cell-expressed developmentally down-regulated 4 ligase
Tree Number: T6.5.3.13.1
database_cross_reference: MSH:C099897

Mediator Complex
type: Class
subclass of: Multiprotein Complexes
subclass of: PMO:00023628
MCID: MC00788332
PMOID: PMO:00018990
Subclass_of: Multiprotein Complexes
Subclass_of: Nuclear Proteins
Synonym: Mediator Complex [Chemical/Ingredient]
Synonym: Mediator Transcription Complex
Tree Number: T6.10.3.36.39
Tree Number: T6.5.3.14
database_cross_reference: MSH:D056892
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000180227

Cyclin C
type: Class
subclass of: Mediator Complex
MCID: MC00749096
PMOID: PMO:00018991
Subclass_of: Mediator Complex
Synonym: CCNC
Synonym: Cyclin C [Chemical/Ingredient]
Synonym: Cyclin, Type C
Synonym: Cyclin-C
Synonym: Cyclins, Type C
Synonym: SRB11 Homolog
Synonym: Type C Cyclin
Synonym: Type C Cyclins
Synonym: hSRB11
Tree Number: T6.5.3.14.1
database_cross_reference: MSH:D056745
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C105396
database_cross_reference: NDFRT:N0000180281

Cyclin-Dependent Kinase 8
type: Class
subclass of: Mediator Complex
MCID: MC00474696
PMOID: PMO:00018992
Subclass_of: Mediator Complex
Synonym: CDK8 protein, human
Synonym: Cell Division Protein Kinase 8
Synonym: EC 2.7.11.22
Synonym: EC 2.7.11.23
Synonym: K35 protein kinase, human
Synonym: Mediator Complex Subunit CDK8
Synonym: Mediator of RNA Polymerase II Transcription Subunit CDK8
Synonym: Protein Kinase K35
Synonym: cell division protein kinase 8, human
Synonym: cyclin-dependent kinase 8, human
Tree Number: T6.5.3.14.2
database_cross_reference: MSH:C095686
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C95299

Mediator Complex Subunit 1
type: Class
subclass of: Mediator Complex
MCID: MC00260072
PMOID: PMO:00018993
Subclass_of: Mediator Complex
Synonym: ARC205
Synonym: Activator-Recruited Cofactor 205 kDa Component
Synonym: DRIP205
Synonym: Mediator Complex Subunit 1 [Chemical/Ingredient]
Synonym: Mediator of RNA Polymerase II Transcription Subunit 1
Synonym: PBP
Synonym: PPAR Binding Protein
Synonym: PPAR-Binding Protein
Synonym: PPARBP
Synonym: PPARG Binding Protein
Tree Number: T6.5.3.14.3
database_cross_reference: MSH:D056913
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C18286
database_cross_reference: NDFRT:N0000180218

Inflammasomes
type: Class
subclass of: Multiprotein Complexes
MCID: MC00797976
PMOID: PMO:00018994
Subclass_of: Multiprotein Complexes
Synonym: Inflammasome
Synonym: Inflammasomes [Chemical/Ingredient]
Synonym: Pyroptosome
Synonym: Pyroptosomes
Tree Number: T6.5.3.15
database_cross_reference: MSH:D058847
database_cross_reference: NDFRT:N0000182123

Calcifying Nanoparticles
type: Class
subclass of: Multiprotein Complexes
MCID: MC00364559
PMOID: PMO:00018995
Subclass_of: Multiprotein Complexes
Synonym: Calcifying Nanoparticle
Synonym: Calcifying Nanoparticles [Chemical/Ingredient]
Synonym: Nanobacteria
Synonym: Nanoparticle, Calcifying
Synonym: Nanoparticles, Calcifying
Tree Number: T6.5.3.16
database_cross_reference: MSH:D059587
database_cross_reference: NDFRT:N0000183497

Axin Signaling Complex
type: Class
subclass of: Multiprotein Complexes
subclass of: PMO:00021684
MCID: MC00450841
PMOID: PMO:00018996
Subclass_of: Intracellular Signaling Peptides and Proteins
Subclass_of: Multiprotein Complexes
Synonym: APC-Axin-1-beta-catenin complex
Synonym: APC-Axin-1-beta-catenin complex location
Synonym: Axin Signaling Complex Proteins
Synonym: Axin Signaling Complex [Chemical/Ingredient]
Synonym: Axin-APC-beta-catenin-GSK3B complex
Synonym: Axin-APC-beta-catenin-GSK3B complex location
Synonym: BDC
Synonym: Destruction Complex, beta-Catenin
Synonym: Signaling Complex, Axin
Synonym: beta Catenin Destruction Complex
Tree Number: T6.10.3.86.65
Tree Number: T6.5.3.17
database_cross_reference: GO:GO:0030877
database_cross_reference: MSH:D060465
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000183499

Adenomatous Polyposis Coli Protein
type: Class
subclass of: Axin Signaling Complex
subclass of: PMO:00022569
MCID: MC00259661
PMOID: PMO:00018997
Subclass_of: Axin Signaling Complex
Subclass_of: Cytoskeletal Proteins
Synonym: Adenomatous Polyposis Coli Protein [Chemical/Ingredient]
Tree Number: T6.10.3.16.9
Tree Number: T6.5.3.17.1
database_cross_reference: MSH:D025601
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169465

Glycogen Synthase Kinase 3
type: Class
subclass of: Axin Signaling Complex
MCID: MC00082521
PMOID: PMO:00018998
Subclass_of: Axin Signaling Complex
Synonym: GLYCOGEN SYNTHASE KINASE 03
Synonym: GSK-3
Synonym: GSK3
Synonym: Glycogen Synthase Kinase 3 [Chemical/Ingredient]
Synonym: Glycogen Synthase Kinase- 3
Synonym: Glycogen synthase kinase-3
Synonym: gsk 3
Synonym: gsk-3
Synonym: gsk-3 Gene Product
Tree Number: T6.5.3.17.2
database_cross_reference: CHV:0000025128
database_cross_reference: LCH_NW:sh2006001666
database_cross_reference: MSH:D038362
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C104099
database_cross_reference: NDFRT:N0000170539

Casein Kinase I
type: Class
subclass of: Axin Signaling Complex
MCID: MC00048378
PMOID: PMO:00019000
Subclass_of: Axin Signaling Complex
Synonym: Casein Kinase 1
Synonym: Casein Kinase I [Chemical/Ingredient]
Synonym: Kinase 1, Casein
Synonym: Kinase I, Casein
Synonym: Protein Kinase CK1
Synonym: Protein Kinase CKI
Synonym: casein kinase I
Tree Number: T6.5.3.17.3
database_cross_reference: MSH:D047389
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170587

Axin Protein
type: Class
subclass of: Axin Signaling Complex
MCID: MC00831079
PMOID: PMO:00019004
Subclass_of: Axin Signaling Complex
Synonym: Axin Protein [Chemical/Ingredient]
Synonym: Axin Proteins
Synonym: Proteins, Axin
Tree Number: T6.5.3.17.4
database_cross_reference: MSH:D060466
database_cross_reference: NDFRT:N0000183531

Polycomb-Group Proteins
type: Class
subclass of: Multiprotein Complexes
MCID: MC00565207
PMOID: PMO:00019005
Subclass_of: Multiprotein Complexes
Synonym: PcG
Synonym: PcG Complex Proteins
Synonym: Polycomb
Synonym: Polycomb Family
Synonym: Polycomb Family Protein
Synonym: Polycomb Group
Synonym: Polycomb Group Protein
Synonym: Polycomb Group Proteins
Synonym: Polycomb Repressive Complex Proteins
Synonym: Polycomb-Group
Tree Number: T6.5.3.18
database_cross_reference: MSH:D063146
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118479
database_cross_reference: NDFRT:N0000185668

Polycomb Repressive Complex 1
type: Class
subclass of: Polycomb-Group Proteins
MCID: MC00457179
PMOID: PMO:00019006
Subclass_of: Polycomb-Group Proteins
Synonym: PRC1
Synonym: PRC1 Protein
Synonym: Polycomb Repressive Complex 1 [Chemical/Ingredient]
Tree Number: T6.5.3.18.1
database_cross_reference: MSH:D063150
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C19866
database_cross_reference: NDFRT:N0000185653

Polycomb Repressive Complex 2
type: Class
subclass of: Polycomb-Group Proteins
MCID: MC00909598
PMOID: PMO:00019007
Subclass_of: Polycomb-Group Proteins
Synonym: Polycomb Repressive Complex 2 [Chemical/Ingredient]
Tree Number: T6.5.3.18.2
database_cross_reference: MSH:D063151
database_cross_reference: NDFRT:N0000185717

Protein Aggregates
type: Class
subclass of: Macromolecular Substances
MCID: MC00976528
PMOID: PMO:00019011
Subclass_of: Macromolecular Substances
Synonym: Aggregates, Protein
Synonym: Protein Aggregates [Chemical/Ingredient]
Tree Number: T6.5.4
database_cross_reference: MSH:D066329
database_cross_reference: NDFRT:N0000191079

Hormones, Hormone Substitutes, and Hormone Antagonists
type: Class
subclass of: Chemical and Drug
subclass of: PMO:00024788
MCID: MC00006394
PMOID: PMO:00019012
Subclass_of: Chemical and Drug
Subclass_of: Physiological Effects of Drugs
Synonym: Hormones, Hormone Substitutes, and Hormone Antagonists [Chemical/Ingredient]
Synonym: Hormones, Substitutes, Antagonists
Tree Number: T6.16.2.2.9
Tree Number: T6.6
database_cross_reference: MSH:D006730
database_cross_reference: NDFRT:N0000011173

Hormone Antagonists
type: Class
subclass of: Hormones, Hormone Substitutes, and Hormone Antagonists
MCID: MC00006390
PMOID: PMO:00019013
Subclass_of: Hormones, Hormone Substitutes, and Hormone Antagonists
Synonym: Antagonists, Hormone
Synonym: Antihormone Agents
Synonym: HORMONE ANTAG
Synonym: Hormone Antagonist
Synonym: Hormone antagonist
Synonym: Hormone antagonist (substance)
Synonym: Hormone antagonists
Synonym: Hormone antagonists (product)
Synonym: Hormone antagonists (substance)
Synonym: hormone antagonist
Tree Number: T6.6.1
database_cross_reference: AOD:0000018719
database_cross_reference: CHV:0000006241
database_cross_reference: CSP:1025-8171
database_cross_reference: LCH:U002228
database_cross_reference: LCH_NW:sh85061977
database_cross_reference: MSH:D006727
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C547
database_cross_reference: RCD:he...
database_cross_reference: SNOMEDCT_US:327298003
database_cross_reference: SNOMEDCT_US:409200004

Mineralocorticoid Receptor Antagonists
type: Class
subclass of: Hormone Antagonists
MCID: MC00547931
PMOID: PMO:00019014
Subclass_of: Hormone Antagonists
Synonym: Aldosterone Receptor Antagonist
Synonym: Aldosterone Receptor Antagonists
Synonym: Antagonists, Aldosterone Receptor
Synonym: Antagonists, Mineralocorticoid
Synonym: Antagonists, Mineralocorticoid Receptor
Synonym: Mineralocorticoid Antagonists
Synonym: Receptor Antagonists, Aldosterone
Synonym: Receptor Antagonists, Mineralocorticoid
Tree Number: T6.6.1.1
database_cross_reference: MSH:D000451
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101255

Androgen Antagonists
type: Class
subclass of: Hormone Antagonists
MCID: MC00000865
PMOID: PMO:00019015
Subclass_of: Hormone Antagonists
Synonym: ANDROGEN ANTAG
Synonym: Antagonists, Androgen
Synonym: Anti-Androgen
Synonym: Anti-Androgen Agents
Synonym: Anti-androgens
Synonym: Anti-androgens (product)
Synonym: Anti-androgens (substance)
Synonym: Antiandrogen
Synonym: Antiandrogen (substance)
Synonym: Antiandrogen Agents
Tree Number: T6.6.1.2
database_cross_reference: CHV:0000001108
database_cross_reference: CSP:0170-7665
database_cross_reference: LCH_NW:sh85005628
database_cross_reference: MEDCIN:76696
database_cross_reference: MSH:D000726
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C242
database_cross_reference: NCI_NCI-GLOSS:CDR0000046052
database_cross_reference: PDQ:CDR0000039255
database_cross_reference: PSY:02435
database_cross_reference: PSY:03042
database_cross_reference: RCD:x000T
database_cross_reference: SNMI:F-B0520
database_cross_reference: SNOMEDCT_US:103024009
database_cross_reference: SNOMEDCT_US:346324007
database_cross_reference: USPMG:MTHU001421

Nonsteroidal Anti-Androgens
type: Class
subclass of: Androgen Antagonists
MCID: MC00447814
PMOID: PMO:00019016
Subclass_of: Androgen Antagonists
Synonym: Anti-Androgens, Nonsteroidal
Synonym: AntiAndrogens, Nonsteroidal
Synonym: Nonsteroidal Anti Androgens
Synonym: Nonsteroidal Antiandrogens
Synonym: Nonsteroidal antiandrogen
Synonym: Nonsteroidal antiandrogen (substance)
Tree Number: T6.6.1.2.1
database_cross_reference: MSH:D057466
database_cross_reference: SNOMEDCT_US:406777002

Androgen Receptor Antagonists
type: Class
subclass of: Androgen Antagonists
MCID: MC00798169
PMOID: PMO:00019017
Subclass_of: Androgen Antagonists
Synonym: Antagonists, Androgen Receptor
Synonym: Receptor Antagonists, Androgen
Tree Number: T6.6.1.2.2
database_cross_reference: MSH:D059002
database_cross_reference: MTH:NOCODE

Estrogen Antagonists
type: Class
subclass of: Hormone Antagonists
MCID: MC00004744
PMOID: PMO:00019018
Subclass_of: Hormone Antagonists
Synonym: Antagonists, Estrogen
Synonym: Anti-Estrogens
Synonym: Anti-estrogens
Synonym: Antiestrogen
Synonym: Antiestrogen (substance)
Synonym: Antiestrogenic
Synonym: Antiestrogens
Synonym: Antiestrogens/Modifiers
Synonym: Antioestrogen
Synonym: ESTROGEN ANTAG
Tree Number: T6.6.1.3
database_cross_reference: ATC:L02BA
database_cross_reference: CHV:0000004677
database_cross_reference: CSP:1065-7679
database_cross_reference: LCH_NW:sh85045013
database_cross_reference: MEDCIN:79422
database_cross_reference: MSH:D004965
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C481
database_cross_reference: NCI_NCI-GLOSS:CDR0000044813
database_cross_reference: NCI_NCI-GLOSS:CDR0000648588
database_cross_reference: PDQ:CDR0000038963
database_cross_reference: PSY:03155
database_cross_reference: PSY:18006
database_cross_reference: RCD:x01Ah
database_cross_reference: RCDAE:x01Ah
database_cross_reference: SNMI:F-B0510
database_cross_reference: SNOMEDCT_US:103023003
database_cross_reference: SNOMEDCT_US:349849001
database_cross_reference: SNOMEDCT_US:373336003
database_cross_reference: USPMG:MTHU001425

Estrogen Receptor Antagonists
type: Class
subclass of: Estrogen Antagonists
MCID: MC00976545
PMOID: PMO:00019019
Subclass_of: Estrogen Antagonists
Synonym: Antagonists, Estrogen Receptor
Synonym: Receptor Antagonists, Estrogen
Tree Number: T6.6.1.3.1
database_cross_reference: MSH:D065171
database_cross_reference: MTH:NOCODE

Insulin Antagonists
type: Class
subclass of: Hormone Antagonists
MCID: MC00006898
PMOID: PMO:00019020
Subclass_of: Hormone Antagonists
Synonym: Antagonists, Insulin
Synonym: INSULIN ANTAG
Synonym: inhibitors insulin
Synonym: insulin antagonist
Synonym: insulin inhibitor
Tree Number: T6.6.1.4
database_cross_reference: CHV:0000006779
database_cross_reference: CSP:2202-1797
database_cross_reference: MSH:D007329

Prostaglandin Antagonists
type: Class
subclass of: Hormone Antagonists
MCID: MC00010737
PMOID: PMO:00019021
Subclass_of: Hormone Antagonists
Synonym: ANTAG PG
Synonym: Antagonist, Prostaglandin
Synonym: Antagonists, Prostaglandin
Synonym: INHIB PG
Synonym: Inhibitor, Prostaglandin
Synonym: Inhibitors, Prostaglandin
Synonym: PG ANTAG
Synonym: PG INHIB
Synonym: PROSTAGLANDIN ANTAG
Synonym: PROSTAGLANDIN INHIB
Tree Number: T6.6.1.5
database_cross_reference: AOD:0000018942
database_cross_reference: CHV:0000010212
database_cross_reference: CSP:1129-2764
database_cross_reference: MSH:D011448

Antithyroid Agents
type: Class
subclass of: Hormone Antagonists
MCID: MC00012826
PMOID: PMO:00019022
Subclass_of: Hormone Antagonists
Synonym: ANTITHYROID AGENTS
Synonym: ANTITHYROID PREPARATIONS
Synonym: Agents, Antithyroid
Synonym: Antagonists, Thyroid
Synonym: Antithyroid Agent
Synonym: Antithyroid Drugs
Synonym: Antithyroid agent
Synonym: Antithyroid agent (product)
Synonym: Antithyroid agent (substance)
Synonym: Antithyroid drugs
Tree Number: T6.6.1.6
database_cross_reference: AOD:0000018727
database_cross_reference: ATC:H03B
database_cross_reference: CHV:0000012256
database_cross_reference: CSP:2928-1545
database_cross_reference: LCH:U004684
database_cross_reference: LCH_NW:sh85135161
database_cross_reference: MEDCIN:40479
database_cross_reference: MSH:D013956
database_cross_reference: MTH:U002306
database_cross_reference: NCI:C885
database_cross_reference: NDFRT:N0000029192
database_cross_reference: PDQ:CDR0000039282
database_cross_reference: RCD:fa...
database_cross_reference: SNM:E-8621
database_cross_reference: SNMI:C-A1801
database_cross_reference: SNOMEDCT_US:418416001
database_cross_reference: SNOMEDCT_US:5067008
database_cross_reference: USPMG:MTHU003307
database_cross_reference: VANDF:4021639

Leukotriene Antagonists
type: Class
subclass of: Hormone Antagonists
MCID: MC00182344
PMOID: PMO:00019023
Subclass_of: Hormone Antagonists
Synonym: ANTAG LEUKOTRIENE
Synonym: Antagonists, Leukotriene
Synonym: Antagonists, Leukotriene Receptor
Synonym: Antileukotrienes
Synonym: LEUKOTRIENE ANTAG
Synonym: LEUKOTRIENE RECEPT ANTAG
Synonym: Leukotriene Receptor Antagonists
Synonym: Leukotriene receptor antagnist
Synonym: Leukotriene receptor antagonist
Synonym: Leukotriene receptor inhibitor
Tree Number: T6.6.1.7
database_cross_reference: CHV:0000041422
database_cross_reference: MEDCIN:78695
database_cross_reference: MSH:D020024
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:cA...
database_cross_reference: SNOMEDCT_US:108616001
database_cross_reference: SNOMEDCT_US:372517002
database_cross_reference: USPMG:MTHU001636

Estrogen Receptor Modulators
type: Class
subclass of: Hormone Antagonists
MCID: MC00259274
PMOID: PMO:00019024
Subclass_of: Hormone Antagonists
Synonym: Antiestrogen
Synonym: Antiestrogens
Synonym: ESTROGEN RECEPT MODULATORS
Synonym: Estrogen Receptor Modulator
Synonym: Modulator, Estrogen Receptor
Synonym: Modulators, Estrogen Receptor
Synonym: Receptor Modulator, Estrogen
Synonym: Receptor Modulators, Estrogen
Synonym: antiestrogen
Synonym: antiestrogens
Tree Number: T6.6.1.8
database_cross_reference: CHV:0000048559
database_cross_reference: MSH:D020847
database_cross_reference: MTH:NOCODE

Selective Estrogen Receptor Modulators
type: Class
subclass of: Estrogen Receptor Modulators
MCID: MC00249162
PMOID: PMO:00019025
Subclass_of: Estrogen Receptor Modulators
Synonym: ESTROGEN RECEPT MODULATORS SELECTIVE
Synonym: Estrogen Receptor Modulator, Selective
Synonym: Estrogen Receptor Modulators, Selective
Synonym: SELECTIVE ESTROGEN RECEPT MODULATORS
Synonym: SERM
Synonym: SERM - Selective estrogen receptor modulator
Synonym: SERM - Selective oestrogen receptor modulator
Synonym: SERMs
Synonym: Select estrogen recpt modultor
Synonym: Selective Estrogen Receptor Modifying Agents
Tree Number: T6.6.1.8.1
database_cross_reference: ATC:G03XC
database_cross_reference: CHV:0000046891
database_cross_reference: CSP:5005-0021
database_cross_reference: LCH_NW:sh98005058
database_cross_reference: MEDCIN:344193
database_cross_reference: MSH:D020845
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C1821
database_cross_reference: NCI_NCI-GLOSS:CDR0000044229
database_cross_reference: NCI_NCI-GLOSS:CDR0000044230
database_cross_reference: RCD:fv...
database_cross_reference: RCDAE:fv...
database_cross_reference: SNOMEDCT_US:109030001
database_cross_reference: SNOMEDCT_US:415515000
database_cross_reference: USPMG:MTHU001390

Calcimimetic Agents
type: Class
subclass of: Hormone Antagonists
MCID: MC00513806
PMOID: PMO:00019026
Subclass_of: Hormone Antagonists
Synonym: ANTI-PARATHYROID AGENTS
Synonym: Agents, Calcimimetic
Synonym: Anti-parathyroid agent
Synonym: Calcimimetic agent
Synonym: Calcimimetic agent (substance)
Tree Number: T6.6.1.9
database_cross_reference: ATC:H05B
database_cross_reference: MSH:D057966
database_cross_reference: SNOMEDCT_US:409389003

Hormones
type: Class
subclass of: Hormones, Hormone Substitutes, and Hormone Antagonists
MCID: MC00006392
PMOID: PMO:00019027
Subclass_of: Hormones, Hormone Substitutes, and Hormone Antagonists
Synonym: Endocrine Gland Secretion
Synonym: Hormone
Synonym: Hormone (substance)
Synonym: Hormone, NOS
Synonym: Hormones [Chemical/Ingredient]
Synonym: Synthetic Hormone
Synonym: Therapeutic Hormone
Synonym: hormone
Synonym: hormones
Synonym: hormones (medication)
Tree Number: T6.6.2
database_cross_reference: AOD:0000001928
database_cross_reference: CHV:0000006244
database_cross_reference: CSP:1025-7345
database_cross_reference: FMA:12278
database_cross_reference: LCH:U002229
database_cross_reference: LCH_NW:sh85061980
database_cross_reference: LNC:LA4003-5
database_cross_reference: LNC:LP28776-0
database_cross_reference: MEDCIN:40956
database_cross_reference: MEDLINEPLUS:1499
database_cross_reference: MSH:D006728
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2315
database_cross_reference: NCI:C548
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000045713
database_cross_reference: NDFRT:N0000011172
database_cross_reference: PSY:23260
database_cross_reference: SNM:F-25000
database_cross_reference: SNMI:F-B0000
database_cross_reference: SNOMEDCT_US:87568004
database_cross_reference: UWDA:12278

Adrenal Cortex Hormones
type: Class
subclass of: Hormones
MCID: MC00000415
PMOID: PMO:00019028
Subclass_of: Hormones
Synonym: ADRENAL CORTICOSTERIODS
Synonym: ADRENAL CORTICOSTEROIDS
Synonym: Adrenal Cortex Hormones [Chemical/Ingredient]
Synonym: Adrenal Cortex Steroids
Synonym: Adrenal cortex hormones
Synonym: Adrenal cortical hormone
Synonym: Adrenal cortical hormone (substance)
Synonym: Adrenal cortical hormone, NOS
Synonym: Adrenocorticosteroids
Synonym: Corticoid
Tree Number: T6.6.2.1
database_cross_reference: AOD:0000018706
database_cross_reference: AOD:0000028357
database_cross_reference: AOD:0000028358
database_cross_reference: CHV:0000000762
database_cross_reference: CHV:0000053814
database_cross_reference: CSP:0059-5614
database_cross_reference: LNC:LP20687-7
database_cross_reference: LNC:LP31653-6
database_cross_reference: MEDLINEPLUS:4557
database_cross_reference: MSH:D000305
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C211
database_cross_reference: NCI:C2322
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000045658
database_cross_reference: NCI_NICHD:C2322
database_cross_reference: NDFRT:N0000011309
database_cross_reference: NDFRT:N0000029178
database_cross_reference: PDQ:CDR0000039257
database_cross_reference: PSY:00990
database_cross_reference: PSY:01000
database_cross_reference: PSY:11990
database_cross_reference: PSY:12000
database_cross_reference: RCD:c6...
database_cross_reference: RCD:m66..
database_cross_reference: RCD:x002V
database_cross_reference: SNM:E-8510
database_cross_reference: SNM:F-26300
database_cross_reference: SNM:U000175
database_cross_reference: SNMI:C-A0102
database_cross_reference: SNMI:F-B2400
database_cross_reference: SNOMEDCT_US:21568003
database_cross_reference: SNOMEDCT_US:320476006
database_cross_reference: SNOMEDCT_US:332333008
database_cross_reference: SNOMEDCT_US:79440004
database_cross_reference: VANDF:4021625

Glucocorticoids
type: Class
subclass of: Adrenal Cortex Hormones
MCID: MC00005662
PMOID: PMO:00019029
Subclass_of: Adrenal Cortex Hormones
Synonym: GLUCOCORTICOIDS
Synonym: Glucocorticoid
Synonym: Glucocorticoid (product)
Synonym: Glucocorticoid (substance)
Synonym: Glucocorticoid hormone
Synonym: Glucocorticoid hormone (substance)
Synonym: Glucocorticoid preparation
Synonym: Glucocorticoid preparation (product)
Synonym: Glucocorticoid preparation (substance)
Synonym: Glucocorticoids [Chemical/Ingredient]
Tree Number: T6.6.2.1.1
database_cross_reference: AOD:0000018814
database_cross_reference: CHV:0000005555
database_cross_reference: CSP:0059-6844
database_cross_reference: LCH:U001987
database_cross_reference: LCH_NW:sh85055358
database_cross_reference: LNC:LP31487-9
database_cross_reference: MEDLINEPLUS:4557
database_cross_reference: MSH:D005938
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2323
database_cross_reference: NCI:C521
database_cross_reference: NCI_NCI-GLOSS:CDR0000045295
database_cross_reference: NCI_NICHD:C2323
database_cross_reference: NDFRT:N0000029312
database_cross_reference: NDFRT:N0000175142
database_cross_reference: PDQ:CDR0000040374
database_cross_reference: PSY:21155
database_cross_reference: RCD:X795h
database_cross_reference: SNMI:F-B0220
database_cross_reference: SNOMEDCT_US:116596006
database_cross_reference: SNOMEDCT_US:255653002
database_cross_reference: SNOMEDCT_US:35150008
database_cross_reference: SNOMEDCT_US:419933005
database_cross_reference: VANDF:4021759

Hydroxycorticosteroids
type: Class
subclass of: Adrenal Cortex Hormones
MCID: MC00006492
PMOID: PMO:00019030
Subclass_of: Adrenal Cortex Hormones
Synonym: Hydroxycorticosteroids [Chemical/Ingredient]
Synonym: hydroxycorticosteroid
Synonym: hydroxycorticosteroids
Tree Number: T6.6.2.1.2
database_cross_reference: AOD:0000018819
database_cross_reference: CHV:0000006378
database_cross_reference: MSH:D006889
database_cross_reference: NDFRT:N0000011308

Gastrointestinal Hormones
type: Class
subclass of: Hormones
MCID: MC00005468
PMOID: PMO:00019033
Subclass_of: Hormones
Synonym: B65-B66 GASTROINTESTINAL HORMONES
Synonym: GASTROINTESTINAL HORMONES
Synonym: GIH - Gastrointestinal hormone
Synonym: Gastrointestinal Hormones [Chemical/Ingredient]
Synonym: Gastrointestinal hormone
Synonym: Gastrointestinal hormone (substance)
Synonym: Gastrointestinal hormone, NOS
Synonym: Gastrointestinal hormones
Synonym: Hormones, Gastrointestinal
Synonym: gastrointestinal hormone
Tree Number: T6.6.2.2
database_cross_reference: AOD:0000018696
database_cross_reference: CHV:0000005386
database_cross_reference: CSP:1248-9164
database_cross_reference: LCH:U001930
database_cross_reference: LCH_NW:sh85053486
database_cross_reference: LNC:LP31655-1
database_cross_reference: MSH:D005768
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000011261
database_cross_reference: RCD:X80Rt
database_cross_reference: SNM:F-27500
database_cross_reference: SNM:U000202
database_cross_reference: SNMI:F-B6500
database_cross_reference: SNOMEDCT_US:31055005

Cholecystokinin
type: Class
subclass of: Gastrointestinal Hormones
subclass of: PMO:00021328
MCID: MC00002708
PMOID: PMO:00019034
Subclass_of: Gastrointestinal Hormones
Subclass_of: Peptides
Synonym: CCK
Synonym: CCK-PZ
Synonym: CCK-PZ - Cholecystokinin-pancreozymin
Synonym: CCK-PZ-Cholecystkin-pancrezym
Synonym: Cholecystikinin
Synonym: Cholecystokinin (substance)
Synonym: Cholecystokinin Inj 75unit/vial
Synonym: Cholecystokinin [Chemical/Ingredient]
Synonym: Cholecystokinin preparation
Synonym: Cholecystokinin preparation (product)
Tree Number: T6.10.2.4
Tree Number: T6.6.2.2.1
database_cross_reference: AOD:0000018782
database_cross_reference: ATC:V04CK02
database_cross_reference: CHV:0000002866
database_cross_reference: CSP:1249-0632
database_cross_reference: DRUGBANK:DB08862
database_cross_reference: DRUGBANK:DB09142
database_cross_reference: FMA:83369
database_cross_reference: LCH:U000986
database_cross_reference: LCH_NW:sh85024642
database_cross_reference: LNC:LP15486-1
database_cross_reference: LNC:LP207662-0
database_cross_reference: LNC:MTHU009340
database_cross_reference: MSH:D002766
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C128853
database_cross_reference: NDDF:001219
database_cross_reference: NDFRT:N0000007750
database_cross_reference: PSY:09015
database_cross_reference: PSY:36250
database_cross_reference: RCD:X80FR
database_cross_reference: RXNORM:2420
database_cross_reference: SNM:F-27510
database_cross_reference: SNMI:C-A2610
database_cross_reference: SNMI:F-B6510
database_cross_reference: SNOMEDCT_US:25085002
database_cross_reference: SNOMEDCT_US:255750006
database_cross_reference: SNOMEDCT_US:46225008

Sincalide
type: Class
subclass of: Cholecystokinin
MCID: MC00249526
PMOID: PMO:00019035
Subclass_of: Cholecystokinin
Synonym: CCK C-terminal octapeptide
Synonym: CCK-8
Synonym: Cholecystokinin C-terminal octapeptide
Synonym: Kinevac
Synonym: Kinevac (sincalide) for Injection 5mcg/vial
Synonym: Kinevac Pws Inj 5mcg/vial
Synonym: SIncalide
Synonym: kinevac
Tree Number: T6.10.2.4.1
database_cross_reference: CHV:0000046916
database_cross_reference: DRUGBANK:DB09142
database_cross_reference: MMSL:1340
database_cross_reference: MSH:D012844
database_cross_reference: NCI:C47719
database_cross_reference: RXNORM:227295

Epidermal Growth Factor
type: Class
subclass of: Gastrointestinal Hormones
subclass of: PMO:00021678
MCID: MC00081586
PMOID: PMO:00019036
Subclass_of: EGF Family of Proteins
Subclass_of: Gastrointestinal Hormones
Synonym: Anthelone U
Synonym: EGF
Synonym: EGF - Epidermal growth factor
Synonym: EGFUG
Synonym: Epidermal Growth Factor [Chemical/Ingredient]
Synonym: Epidermal Growth Factor-Urogastrone
Synonym: Epidermal growth factor
Synonym: Epidermal growth factor (substance)
Synonym: Epidermal growth factor (substance) [Ambiguous]
Synonym: Growth Factor, Epidermal
Tree Number: T6.13.12.25.1
Tree Number: T6.6.2.2.2
database_cross_reference: AOD:0000018785
database_cross_reference: AOD:0000028438
database_cross_reference: AOD:0000028439
database_cross_reference: CHV:0000024758
database_cross_reference: CSP:1354-9315
database_cross_reference: LCH_NW:sh89005597
database_cross_reference: LNC:LP18547-7
database_cross_reference: LNC:MTHU004615
database_cross_reference: MSH:D004815
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C20425
database_cross_reference: NCI_NCI-GLOSS:CDR0000653114
database_cross_reference: NCI_NCI-GLOSS:CDR0000653115
database_cross_reference: NDFRT:N0000170995
database_cross_reference: PDQ:CDR0000354196
database_cross_reference: RCD:X80PR
database_cross_reference: RXNORM:1427158
database_cross_reference: SNMI:F-CB980
database_cross_reference: SNOMEDCT_US:259616001
database_cross_reference: SNOMEDCT_US:359600002
database_cross_reference: SNOMEDCT_US:84102004

Gastric Inhibitory Polypeptide
type: Class
subclass of: Gastrointestinal Hormones
subclass of: Peptide Hormones
subclass of: PMO:00021344
MCID: MC00005451
PMOID: PMO:00019037
Subclass_of: Gastrointestinal Hormones
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: GASTRIC INHIB POLYPEPTIDE
Synonym: GIP
Synonym: GIP - Gastric inhibitory peptide
Synonym: GIP - Gastric inhibitory polypeptide
Synonym: GIP - Glucose dependent insulinotropic peptide
Synonym: GIP 1-42
Synonym: GIP-Gastric inhibitory peptide
Synonym: GIP-Gastric inhibitory polypep
Synonym: Gastric Inhibitory Polypeptide [Chemical/Ingredient]
Synonym: Gastric inhibitory peptide
Tree Number: T6.10.2.12.8
Tree Number: T6.10.2.32.4
Tree Number: T6.6.2.2.3
Tree Number: T6.6.2.8.4
database_cross_reference: AOD:0000018783
database_cross_reference: AOD:0000028437
database_cross_reference: CHV:0000005369
database_cross_reference: CSP:1248-9368
database_cross_reference: LNC:LP15592-6
database_cross_reference: LNC:MTHU011152
database_cross_reference: MSH:D005749
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C104432
database_cross_reference: NDFRT:N0000170369
database_cross_reference: RCD:X80Fb
database_cross_reference: SNM:F-27540
database_cross_reference: SNMI:F-B6540
database_cross_reference: SNOMEDCT_US:37756007
database_cross_reference: SNOMEDCT_US:416401008

Gastrins
type: Class
subclass of: Gastrointestinal Hormones
subclass of: Peptide Hormones
subclass of: PMO:00021344
MCID: MC00005458
PMOID: PMO:00019038
Subclass_of: Gastrointestinal Hormones
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: Gastrin
Synonym: Gastrins [Chemical/Ingredient]
Synonym: gastrins
Tree Number: T6.10.2.12.9
Tree Number: T6.10.2.32.5
Tree Number: T6.6.2.2.4
Tree Number: T6.6.2.8.5
database_cross_reference: CHV:0000005375
database_cross_reference: FMA:83366
database_cross_reference: MSH:D005755
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000011321

Pentagastrin
type: Class
subclass of: PMO:00021376
MCID: MC00009827
PMOID: PMO:00019039
Subclass_of: Oligopeptides
Synonym: Gastrin Pentapeptide
Synonym: L-Phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-
Synonym: PENTAGASTRIN
Synonym: PG - Pentagastrin
Synonym: Pentagastrin (substance)
Synonym: Pentagastrin [Chemical/Ingredient]
Synonym: Pentagastrin preparation
Synonym: Pentagastrin preparation (product)
Synonym: Pentagastrin preparation (substance)
Synonym: Pentagastrin product
Tree Number: T6.10.2.13.14
database_cross_reference: AOD:0000020275
database_cross_reference: ATC:V04CG04
database_cross_reference: CHV:0000009435
database_cross_reference: DRUGBANK:DB00183
database_cross_reference: LNC:LP32702-0
database_cross_reference: MEDCIN:48802
database_cross_reference: MMSL:5249
database_cross_reference: MMSL:d04022
database_cross_reference: MSH:D010418
database_cross_reference: MTHSPL:EF0NX91490
database_cross_reference: NCI:C66340
database_cross_reference: NCI_FDA:EF0NX91490
database_cross_reference: NDDF:001146
database_cross_reference: NDFRT:N0000005708
database_cross_reference: NDFRT:N0000146822
database_cross_reference: RCD:X79A2
database_cross_reference: RCD:x04ox
database_cross_reference: RXNORM:7993
database_cross_reference: SNM:F-27350
database_cross_reference: SNMI:C-A2634
database_cross_reference: SNMI:F-B6110
database_cross_reference: SNOMEDCT_US:10782005
database_cross_reference: SNOMEDCT_US:358180008
database_cross_reference: SNOMEDCT_US:48264002
database_cross_reference: VANDF:4018500

Tetragastrin
type: Class
subclass of: PMO:00021376
MCID: MC00012652
PMOID: PMO:00019040
Subclass_of: Oligopeptides
Synonym: AOC Tetragastrin
Synonym: AOC Tetrapeptide
Synonym: AOC-Tetragastrin
Synonym: AOC-Tetrapeptide
Synonym: CCK (30-33)
Synonym: CCK 04
Synonym: CCK-4
Synonym: CKK-4
Synonym: Cholecystokinin (30-33)
Synonym: Cholecystokinin 4
Tree Number: T6.10.2.13.19
database_cross_reference: MSH:D013758
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170302

Motilin
type: Class
subclass of: Gastrointestinal Hormones
subclass of: Peptide Hormones
subclass of: PMO:00021344
MCID: MC00008422
PMOID: PMO:00019041
Subclass_of: Gastrointestinal Hormones
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: Motilin (substance)
Synonym: Motilin [Chemical/Ingredient]
Synonym: Motilin preparation
Synonym: Motilin preparation (product)
Synonym: Motilin preparation (substance)
Synonym: motilin
Tree Number: T6.10.2.12.11
Tree Number: T6.10.2.32.8
Tree Number: T6.6.2.2.5
Tree Number: T6.6.2.8.9
database_cross_reference: AOD:0000018763
database_cross_reference: CHV:0000008268
database_cross_reference: CSP:1248-9164
database_cross_reference: FMA:83368
database_cross_reference: LCH_NW:sh89003565
database_cross_reference: LNC:LP18278-9
database_cross_reference: LNC:MTHU003274
database_cross_reference: MSH:D009037
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170392
database_cross_reference: RCD:X80G0
database_cross_reference: SNM:F-27560
database_cross_reference: SNMI:C-A2640
database_cross_reference: SNMI:F-B6580
database_cross_reference: SNOMEDCT_US:1758005
database_cross_reference: SNOMEDCT_US:33752008

Secretin
type: Class
subclass of: Gastrointestinal Hormones
subclass of: Peptide Hormones
subclass of: PMO:00021344
MCID: MC00011698
PMOID: PMO:00019042
Subclass_of: Gastrointestinal Hormones
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: Pancreatic secretin
Synonym: SECRETIN
Synonym: Secremax
Synonym: Secretin (substance)
Synonym: Secretin Inj 75unit/vial
Synonym: Secretin [Chemical/Ingredient]
Synonym: Secretin preparation
Synonym: Secretin preparation (product)
Synonym: Secretin preparation (substance)
Synonym: secretin
Tree Number: T6.10.2.12.18
Tree Number: T6.10.2.32.15
Tree Number: T6.6.2.2.6
Tree Number: T6.6.2.8.16
database_cross_reference: AOD:0000018786
database_cross_reference: ATC:V04CK01
database_cross_reference: CHV:0000011156
database_cross_reference: CSP:1249-1299
database_cross_reference: DRUGBANK:DB00021
database_cross_reference: FMA:83372
database_cross_reference: LCH:U004252
database_cross_reference: LCH_NW:sh85119447
database_cross_reference: LNC:LP15860-7
database_cross_reference: LNC:LP32704-6
database_cross_reference: LNC:MTHU013917
database_cross_reference: MEDCIN:41017
database_cross_reference: MMSL:16599
database_cross_reference: MMSL:5447
database_cross_reference: MMSL:d04161
database_cross_reference: MSH:D012633
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C66531
database_cross_reference: NCI_FDA:88C55N56UU
database_cross_reference: NCI_NCI-GLOSS:CDR0000658055
database_cross_reference: NDDF:002121
database_cross_reference: NDFRT:N0000006078
database_cross_reference: NDFRT:N0000146453
database_cross_reference: RCD:X80GR
database_cross_reference: RXNORM:9627
database_cross_reference: SNM:F-27520
database_cross_reference: SNMI:C-A2650
database_cross_reference: SNMI:F-B6520
database_cross_reference: SNOMEDCT_US:19205004
database_cross_reference: SNOMEDCT_US:68622003
database_cross_reference: VANDF:4018115

Vasoactive Intestinal Peptide
type: Class
subclass of: Gastrointestinal Hormones
subclass of: Peptide Hormones
subclass of: PMO:00021344
MCID: MC00466545
PMOID: PMO:00019043
Subclass_of: Gastrointestinal Hormones
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: PHM27
Synonym: VASOACTIVE INTESTINAL PEPTIDE
Synonym: VIP
Synonym: VIP Gene
Synonym: VIP gene
Synonym: Vasoactive Intestinal Peptide Gene
Synonym: prepro-VIP
Synonym: vasoactive intestinal peptide
Tree Number: T6.10.2.12.19
Tree Number: T6.10.2.32.18
Tree Number: T6.6.2.2.7
Tree Number: T6.6.2.8.18
database_cross_reference: HGNC:HGNC:12693
database_cross_reference: MTH:NOCODE
database_cross_reference: NCBI_Gene:27151
database_cross_reference: NCBI_Gene:7432
database_cross_reference: NCI:C21411
database_cross_reference: OMIM:192320

Gastrin-Releasing Peptide
type: Class
subclass of: Gastrointestinal Hormones
subclass of: PMO:00021344
MCID: MC00027435
PMOID: PMO:00019044
Subclass_of: Gastrointestinal Hormones
Subclass_of: Neuropeptides
Synonym: GASTRIN RELEASING PEPTIDE A 001 027
Synonym: GRP
Synonym: Gastrin Releasing Peptide
Synonym: Gastrin releasing peptide
Synonym: Gastrin releasing peptide (substance)
Synonym: Gastrin releasing polypeptide
Synonym: Gastrin-Releasing Peptide (1-27)
Synonym: Gastrin-Releasing Peptide [Chemical/Ingredient]
Synonym: Gastrin-releasing peptide
Synonym: Gastrin-releasing peptide (substance)
Tree Number: T6.10.2.12.26
Tree Number: T6.6.2.2.8
database_cross_reference: CHV:0000014078
database_cross_reference: CSP:4007-0014
database_cross_reference: CSP:4007-0050
database_cross_reference: LNC:LP15593-4
database_cross_reference: LNC:MTHU010953
database_cross_reference: MSH:D019886
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2272
database_cross_reference: NDFRT:N0000170383
database_cross_reference: RCD:X79A0
database_cross_reference: SNMI:F-B6550
database_cross_reference: SNOMEDCT_US:255749006
database_cross_reference: SNOMEDCT_US:64657006

Peptide YY
type: Class
subclass of: Gastrointestinal Hormones
subclass of: Peptide Hormones
MCID: MC00034496
PMOID: PMO:00019045
Subclass_of: Gastrointestinal Hormones
Subclass_of: Peptide Hormones
Synonym: PYY
Synonym: PYY Peptide
Synonym: PYY hormone
Synonym: PYY-I
Synonym: Peptide Tyrosine Tyrosine
Synonym: Peptide YY (substance)
Synonym: Peptide YY [Chemical/Ingredient]
Synonym: Peptide, PYY
Synonym: peptide YY (PYY)
Synonym: peptide yy
Tree Number: T6.10.2.32.19
Tree Number: T6.6.2.2.9
Tree Number: T6.6.2.8.19
database_cross_reference: CHV:0000014594
database_cross_reference: LNC:LP64933-2
database_cross_reference: LNC:MTHU026391
database_cross_reference: MSH:D019894
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C104812
database_cross_reference: NDFRT:N0000170336
database_cross_reference: SNMI:F-B7020
database_cross_reference: SNOMEDCT_US:80537001

Proglucagon
type: Class
subclass of: Gastrointestinal Hormones
subclass of: PMO:00023688
MCID: MC00035883
PMOID: PMO:00019046
Subclass_of: Gastrointestinal Hormones
Subclass_of: Protein Precursors
Synonym: Pro Glucagon
Synonym: Pro-Glucagon
Synonym: Proglucagon (substance)
Synonym: Proglucagon [Chemical/Ingredient]
Synonym: Proglucagon, NOS
Tree Number: T6.10.3.45.10
Tree Number: T6.6.2.2.10
database_cross_reference: MSH:D052336
database_cross_reference: NDFRT:N0000170389
database_cross_reference: SNM:F-27420
database_cross_reference: SNMI:F-B6320
database_cross_reference: SNOMEDCT_US:45946003

Hormones, Ectopic
type: Class
subclass of: Hormones
subclass of: PMO:00024394
MCID: MC00006393
PMOID: PMO:00019053
Subclass_of: Biomarkers, Tumor
Subclass_of: Hormones
Synonym: Ectopic Hormones
Synonym: Hormones, Ectopic [Chemical/Ingredient]
Tree Number: T6.13.9.5.4
Tree Number: T6.6.2.3
database_cross_reference: LCH:U002230
database_cross_reference: LCH_NW:sh85061982
database_cross_reference: MSH:D006729
database_cross_reference: NDFRT:N0000171372

Invertebrate Hormones
type: Class
subclass of: Hormones
PMOID: PMO:00019054
Subclass_of: Hormones
Tree Number: T6.6.2.4

Insect Hormones
type: Class
subclass of: Invertebrate Hormones
PMOID: PMO:00019055
Subclass_of: Invertebrate Hormones
Tree Number: T6.6.2.4.1

Thymus Hormones
type: Class
subclass of: Hormones
MCID: MC00012822
PMOID: PMO:00019058
Subclass_of: Hormones
Synonym: B4 THYMIC HORMONES
Synonym: Hormones, Thymic
Synonym: Hormones, Thymus
Synonym: THYMIC HORMONES
Synonym: Thymic Hormones
Synonym: Thymic hormone
Synonym: Thymic hormone (substance)
Synonym: Thymic hormone, NOS
Synonym: Thymic hormones
Synonym: Thymus Hormones [Chemical/Ingredient]
Tree Number: T6.6.2.6
database_cross_reference: AOD:0000018718
database_cross_reference: CSP:0432-2915
database_cross_reference: LCH_NW:sh85135139
database_cross_reference: MSH:D013951
database_cross_reference: NDFRT:N0000167480
database_cross_reference: SNM:F-26800
database_cross_reference: SNM:U000198
database_cross_reference: SNMI:F-B4000
database_cross_reference: SNOMEDCT_US:38245005

Thymic Factor, Circulating
type: Class
subclass of: Thymus Hormones
subclass of: PMO:00021376
MCID: MC00012799
PMOID: PMO:00019059
Subclass_of: Oligopeptides
Subclass_of: Thymus Hormones
Synonym: CIRC FACTOR THYMIC
Synonym: Circulating Factor, Thymic
Synonym: Circulating Thymic Factor
Synonym: FACTOR THYMIC CIRC
Synonym: Facteur Thymique Serique
Synonym: Factor, Circulating Thymic
Synonym: Factor, Serum Thymic
Synonym: Factor, Thymic Circulating
Synonym: Factor, Thymic Serum
Synonym: Nonathymulin
Tree Number: T6.10.2.13.20
Tree Number: T6.6.2.6.1
database_cross_reference: CHV:0000012236
database_cross_reference: CSP:0432-9514
database_cross_reference: MSH:D013935
database_cross_reference: NDFRT:N0000170306

Thymopoietins
type: Class
subclass of: Thymus Hormones
MCID: MC00012816
PMOID: PMO:00019060
Subclass_of: Thymus Hormones
Synonym: TMPO Gene Product
Synonym: Thymic neuromuscular function blocking agent
Synonym: Thymic neuromuscular function blocking agent (substance)
Synonym: Thymin
Synonym: Thymins
Synonym: Thymopoietin
Synonym: Thymopoietins [Chemical/Ingredient]
Synonym: thymopoietin
Synonym: thymopoietins
Tree Number: T6.6.2.6.2
database_cross_reference: CHV:0000012248
database_cross_reference: CSP:0432-9514
database_cross_reference: MSH:D013946
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C882
database_cross_reference: NDFRT:N0000167481
database_cross_reference: SNM:F-26830
database_cross_reference: SNMI:F-B4030
database_cross_reference: SNOMEDCT_US:49067007

Thymosin
type: Class
subclass of: Thymus Hormones
subclass of: Peptide Hormones
subclass of: PMO:00021871
MCID: MC00012817
PMOID: PMO:00019062
Subclass_of: Peptide Hormones
Subclass_of: Proteins
Subclass_of: Thymus Hormones
Synonym: THYM
Synonym: Thymosin (substance)
Synonym: Thymosin [Chemical/Ingredient]
Synonym: Thymosins
Synonym: thymosin
Synonym: thymosins
Tree Number: T6.10.2.32.16
Tree Number: T6.10.3.54
Tree Number: T6.6.2.6.3
database_cross_reference: AOD:0000018791
database_cross_reference: CHV:0000012249
database_cross_reference: CSP:0432-9563
database_cross_reference: FMA:67128
database_cross_reference: LCH:U004680
database_cross_reference: LCH_NW:sh85135144
database_cross_reference: MSH:D013947
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2284
database_cross_reference: NDFRT:N0000170332
database_cross_reference: PDQ:CDR0000039716
database_cross_reference: SNM:F-26810
database_cross_reference: SNMI:F-B4010
database_cross_reference: SNOMEDCT_US:51305002
database_cross_reference: UWDA:67128

Thyroid Hormones
type: Class
subclass of: Hormones
MCID: MC00012832
PMOID: PMO:00019063
Subclass_of: Hormones
Synonym: B30-B31 THYROID HORMONES
Synonym: Hormones, Thyroid
Synonym: THYROID HORMONES
Synonym: Thyroid Gland Hormone
Synonym: Thyroid Hormone
Synonym: Thyroid Hormones [Chemical/Ingredient]
Synonym: Thyroid hormone
Synonym: Thyroid hormone (substance)
Synonym: Thyroid hormone, NOS
Synonym: Thyroid hormones
Tree Number: T6.6.2.7
database_cross_reference: AOD:0000018710
database_cross_reference: ATC:H03AA
database_cross_reference: CHV:0000012264
database_cross_reference: CSP:2928-9974
database_cross_reference: LCH:U004686
database_cross_reference: LCH_NW:sh85135174
database_cross_reference: LNC:LP31666-8
database_cross_reference: MSH:D013963
database_cross_reference: NCI:C886
database_cross_reference: NCI_NCI-GLOSS:CDR0000044558
database_cross_reference: NDFRT:N0000011247
database_cross_reference: PSY:53120
database_cross_reference: RCD:Xa9wK
database_cross_reference: RCD:f9...
database_cross_reference: SNM:F-26900
database_cross_reference: SNM:U000199
database_cross_reference: SNMI:F-B3000
database_cross_reference: SNOMEDCT_US:18220004
database_cross_reference: SNOMEDCT_US:325311005
database_cross_reference: SNOMEDCT_US:61020000

Dextrothyroxine
type: Class
subclass of: Thyroid Hormones
MCID: MC00003791
PMOID: PMO:00019064
Subclass_of: Thyroid Hormones
Synonym: Choloxin - Tab 4mg
Synonym: Choloxin Tab 2mg
Synonym: Choloxin Tablet 4mg
Synonym: D Thyroxine
Synonym: D-T4
Synonym: D-T4 Thyroid Hormone
Synonym: D-Thyroxine
Synonym: D-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
Synonym: D-thyroxine
Synonym: D-thyroxine preparation
Tree Number: T6.6.2.7.1
database_cross_reference: ATC:C10AX01
database_cross_reference: DRUGBANK:DB00509
database_cross_reference: MEDCIN:40454
database_cross_reference: MSH:D003918
database_cross_reference: NCI:C61719
database_cross_reference: NCI_FDA:4W9K63FION
database_cross_reference: NDDF:004779
database_cross_reference: NDFRT:N0000006174
database_cross_reference: NDFRT:N0000020406
database_cross_reference: RXNORM:3292
database_cross_reference: SNM:E-898X
database_cross_reference: SNMI:C-80650
database_cross_reference: SNMI:C-A1814
database_cross_reference: SNOMEDCT_US:59170000
database_cross_reference: SNOMEDCT_US:847003
database_cross_reference: VANDF:4022400

Diiodotyrosine
type: Class
subclass of: Thyroid Hormones
MCID: MC00003943
PMOID: PMO:00019065
Subclass_of: Thyroid Hormones
Synonym: Acid, Iodogorgoic
Synonym: Diiodotyrosine (substance)
Synonym: Diiodotyrosine [Chemical/Ingredient]
Synonym: Iodogorgoic Acid
Synonym: Tyrosine, 3,5-diiodo-
Synonym: diiodotyrosine
Tree Number: T6.6.2.7.2
database_cross_reference: ATC:H03BX01
database_cross_reference: MSH:D004105
database_cross_reference: NDDF:007143
database_cross_reference: NDFRT:N0000170245
database_cross_reference: SNM:F-10350
database_cross_reference: SNMI:F-64512
database_cross_reference: SNOMEDCT_US:80393001

Monoiodotyrosine
type: Class
subclass of: Thyroid Hormones
MCID: MC00007012
PMOID: PMO:00019066
Subclass_of: Thyroid Hormones
Synonym: Iodotyrosine
Synonym: L-Tyrosine, iodo-
Synonym: Monoiodotyrosine (substance)
Synonym: Monoiodotyrosine [Chemical/Ingredient]
Synonym: iodotyrosine
Tree Number: T6.6.2.7.3
database_cross_reference: CSP:0777-8469
database_cross_reference: MSH:D007470
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170246
database_cross_reference: SNM:F-10340
database_cross_reference: SNMI:F-64511
database_cross_reference: SNOMEDCT_US:91166002

Thyroid (USP)
type: Class
subclass of: Thyroid Hormones
MCID: MC00012831
PMOID: PMO:00019067
Subclass_of: Thyroid Hormones
Synonym: Desiccated Thyroid Extract
Synonym: Desiccated Thyroid Gland
Synonym: Dessicated Thyroid Extract
Synonym: Dried Thyroid
Synonym: Dried Thyroid Extract
Synonym: Extract, Dried Thyroid
Synonym: THYROID
Synonym: THYROID, UNSPECIFIED
Synonym: Thyroid
Synonym: Thyroid (USP) [Chemical/Ingredient]
Tree Number: T6.6.2.7.4
database_cross_reference: CHV:0000012263
database_cross_reference: MMSL:2158
database_cross_reference: MMSL:5579
database_cross_reference: MMSL:d00655
database_cross_reference: MSH:D013962
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:0B4FDL9I6P
database_cross_reference: NCI:C84662
database_cross_reference: NCI_FDA:0B4FDL9I6P
database_cross_reference: NDDF:002128
database_cross_reference: NDDF:009666
database_cross_reference: NDFRT:N0000145808
database_cross_reference: NDFRT:N0000167484
database_cross_reference: RXNORM:10572
database_cross_reference: VANDF:4017420

Thyronines
type: Class
subclass of: Thyroid Hormones
MCID: MC00012839
PMOID: PMO:00019068
Subclass_of: Thyroid Hormones
Synonym: Thyronines [Chemical/Ingredient]
Tree Number: T6.6.2.7.5
database_cross_reference: LCH_NW:sh85135179
database_cross_reference: MSH:D013970
database_cross_reference: NDFRT:N0000007631

Thyroxine
type: Class
subclass of: Thyroid Hormones
MCID: MC00012845
PMOID: PMO:00019072
Subclass_of: Thyroid Hormones
Synonym: 3,3',5,5'-Tetraiodo-L-thyronine
Synonym: 3,5,3',5'-TETRAIODO-L-thyronine
Synonym: 3,5,3',5'-Tetraiodothyronine
Synonym: 3,5,3'5' Tetraiodothyronine
Synonym: 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine
Synonym: Eltroxin 150 Tab
Synonym: Eltroxin Tab 100mcg
Synonym: Eltroxin Tab 200mcg
Synonym: Eltroxin Tab 300mcg
Synonym: Eltroxin Tab 50mcg
Tree Number: T6.6.2.7.6
database_cross_reference: AOD:0000018732
database_cross_reference: CHV:0000012274
database_cross_reference: CSP:2929-0910
database_cross_reference: DRUGBANK:DB00451
database_cross_reference: LCH:U004691
database_cross_reference: LCH_NW:sh85135182
database_cross_reference: LNC:LP145811-8
database_cross_reference: MMSL:d00278
database_cross_reference: MSH:D013974
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000339
database_cross_reference: MTHSPL:Q51BO43MG4
database_cross_reference: NCI:C2302
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000533434
database_cross_reference: NCI_NCI-GLOSS:CDR0000556432
database_cross_reference: NCI_NCI-GLOSS:CDR0000556433
database_cross_reference: NCI_NCI-GLOSS:CDR0000556436
database_cross_reference: NDDF:005896
database_cross_reference: NDFRT:N0000007632
database_cross_reference: NDFRT:N0000020132
database_cross_reference: PDQ:CDR0000039298
database_cross_reference: PDQ:CDR0000528273
database_cross_reference: PSY:53180
database_cross_reference: RCD:X80Ge
database_cross_reference: RCD:x01Ln
database_cross_reference: RXNORM:10582
database_cross_reference: SNMI:C-A1810
database_cross_reference: SNMI:F-B3010
database_cross_reference: SNOMEDCT_US:38076006
database_cross_reference: SNOMEDCT_US:73187006
database_cross_reference: USPMG:MTHU001394
database_cross_reference: VANDF:4022126

Peptide Hormones
type: Class
subclass of: Hormones
subclass of: PMO:00021328
MCID: MC00182957
PMOID: PMO:00019073
Subclass_of: Hormones
Subclass_of: Peptides
Synonym: Hormones, Peptide
Synonym: Peptide Hormone
Synonym: Peptide Hormones [Chemical/Ingredient]
Synonym: Peptide hormone
Synonym: Peptide hormones
Synonym: hormones peptides
Synonym: peptide hormone
Synonym: peptide hormones
Tree Number: T6.10.2.32
Tree Number: T6.6.2.8
database_cross_reference: CHV:0000041687
database_cross_reference: CSP:1025-7446
database_cross_reference: FMA:83352
database_cross_reference: LCH_NW:sh85099689
database_cross_reference: MSH:D036361
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C1746
database_cross_reference: NDFRT:N0000011202

Angiotensins
type: Class
subclass of: Peptide Hormones
subclass of: PMO:00021344
subclass of: PMO:00021376
subclass of: PMO:00024397
MCID: MC00000936
PMOID: PMO:00019074
Subclass_of: Autacoids
Subclass_of: Neuropeptides
Subclass_of: Oligopeptides
Subclass_of: Peptide Hormones
Synonym: Angiotensin
Synonym: Angiotensin (substance)
Synonym: Angiotensin, NOS
Synonym: Angiotensins [Chemical/Ingredient]
Synonym: angiotensin
Synonym: angiotensins
Tree Number: T6.10.2.12.2
Tree Number: T6.10.2.13.3
Tree Number: T6.10.2.32.1
Tree Number: T6.13.10.2.1
Tree Number: T6.6.2.8.1
database_cross_reference: AOD:0000018746
database_cross_reference: CHV:0000001187
database_cross_reference: CSP:2237-6950
database_cross_reference: LCH:U000250
database_cross_reference: LCH_NW:sh85005038
database_cross_reference: LNC:LP40491-0
database_cross_reference: MSH:D000809
database_cross_reference: MTH:U001700
database_cross_reference: NCI:C248
database_cross_reference: NDFRT:N0000171046
database_cross_reference: PSY:02550
database_cross_reference: RCD:Xa9uR
database_cross_reference: SNM:E-8973
database_cross_reference: SNMI:C-97380
database_cross_reference: SNOMEDCT_US:304274007
database_cross_reference: SNOMEDCT_US:9974009

Bombesin
type: Class
subclass of: Peptide Hormones
subclass of: PMO:00021344
subclass of: PMO:00024247
MCID: MC00001857
PMOID: PMO:00019078
Subclass_of: Amphibian Venoms
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: 5-oxoPro-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-MetNH2
Synonym: BOMBESIN
Synonym: Bombesin (substance)
Synonym: Bombesin 14
Synonym: Bombesin [Chemical/Ingredient]
Synonym: bombesin
Tree Number: T6.10.2.12.3
Tree Number: T6.10.2.32.2
Tree Number: T6.12.12.1.2
Tree Number: T6.6.2.8.2
database_cross_reference: AOD:0000018781
database_cross_reference: CHV:0000002057
database_cross_reference: CSP:2058-8360
database_cross_reference: DRUGBANK:DB11724
database_cross_reference: LCH_NW:sh88007757
database_cross_reference: LNC:LP14908-5
database_cross_reference: LNC:MTHU002158
database_cross_reference: MSH:D001839
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C315
database_cross_reference: NCI_FDA:PX9AZU7QPK
database_cross_reference: NCI_NCI-GLOSS:CDR0000661162
database_cross_reference: NDFRT:N0000171438
database_cross_reference: PSY:06523
database_cross_reference: RCD:X80FF
database_cross_reference: SNM:F-27550
database_cross_reference: SNMI:F-B6570
database_cross_reference: SNOMEDCT_US:56714008

Calcitonin
type: Class
subclass of: Peptide Hormones
subclass of: PMO:00021344
MCID: MC00002102
PMOID: PMO:00019079
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: CALCITONIN
Synonym: CT - Calcitonin
Synonym: Calcitonin (substance)
Synonym: Calcitonin [Chemical/Ingredient]
Synonym: Calcitonin agent
Synonym: Calcitonin agent (substance)
Synonym: Calcitonin(1-32)
Synonym: Calcitrin
Synonym: Thyrocalcitonin
Synonym: calcitonin
Tree Number: T6.10.2.12.5
Tree Number: T6.10.2.32.3
Tree Number: T6.6.2.8.3
database_cross_reference: AOD:0000018771
database_cross_reference: CHV:0000002289
database_cross_reference: CSP:2929-0286
database_cross_reference: FMA:83348
database_cross_reference: LCH:U000739
database_cross_reference: LCH_NW:sh85018767
database_cross_reference: LNC:LP14649-5
database_cross_reference: LNC:MTHU003443
database_cross_reference: MMSL:d00598
database_cross_reference: MSH:D002116
database_cross_reference: MTH:U001773
database_cross_reference: MTHSPL:DF35I47HCM
database_cross_reference: NDDF:005019
database_cross_reference: NDFRT:N0000006509
database_cross_reference: NDFRT:N0000022460
database_cross_reference: PDQ:CDR0000039292
database_cross_reference: RCD:XM0lH
database_cross_reference: RXNORM:1311287
database_cross_reference: SNM:F-26960
database_cross_reference: SNMI:F-B3140
database_cross_reference: SNOMEDCT_US:373474005
database_cross_reference: SNOMEDCT_US:63730009
database_cross_reference: VANDF:4018749

Gonadotropins
type: Class
subclass of: Peptide Hormones
MCID: MC00005801
PMOID: PMO:00019080
Subclass_of: Peptide Hormones
Synonym: A10 GONADOTROPIN PREPARATIONS
Synonym: GONADOTROPIN PREPARATIONS
Synonym: GONADOTROPINS
Synonym: Gonadotrophic hormone
Synonym: Gonadotrophic hormone (product)
Synonym: Gonadotrophic hormone (substance)
Synonym: Gonadotrophin
Synonym: Gonadotrophin preparation
Synonym: Gonadotrophin preparation, NOS
Synonym: Gonadotrophins, NOS
Tree Number: T6.6.2.8.6
database_cross_reference: AOD:0000018700
database_cross_reference: ATC:G03GA
database_cross_reference: CHV:0000005654
database_cross_reference: CSP:2334-3653
database_cross_reference: FMA:83362
database_cross_reference: LCH:U002024
database_cross_reference: LCH_NW:sh85055839
database_cross_reference: MEDCIN:41006
database_cross_reference: MSH:D006062
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2273
database_cross_reference: NDFRT:N0000011199
database_cross_reference: NDFRT:N0000029182
database_cross_reference: PSY:21300
database_cross_reference: PSY:21310
database_cross_reference: RCD:x01Ls
database_cross_reference: SNM:F-27110
database_cross_reference: SNMI:C-A1000
database_cross_reference: SNMI:F-B5010
database_cross_reference: SNOMEDCT_US:31895006
database_cross_reference: SNOMEDCT_US:350362009
database_cross_reference: SNOMEDCT_US:86979005
database_cross_reference: VANDF:4021629

Chorionic Gonadotropin
type: Class
subclass of: PMO:00023681
MCID: MC00005802
PMOID: PMO:00019081
Subclass_of: Pregnancy Proteins
Synonym: CG - Chorionic gonadotrophin
Synonym: CG - Chorionic gonadotropin
Synonym: CG preparation
Synonym: Choriogonadotrophin
Synonym: Choriogonadotropin
Synonym: Choriogonadotropin (substance)
Synonym: Choriogonadotropin intact
Synonym: Chorionic Gonadotropin [Chemical/Ingredient]
Synonym: Chorionic gonadotrophin
Synonym: Chorionic gonadotrophin preparation
Tree Number: T6.10.3.42.3
database_cross_reference: CSP:2586-9327
database_cross_reference: LCH_NW:sh85024750
database_cross_reference: LNC:LP14651-1
database_cross_reference: LNC:MTHU001935
database_cross_reference: MSH:D006063
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000006057
database_cross_reference: NDFRT:N0000145997
database_cross_reference: NDFRT:N0000145998
database_cross_reference: RCD:fk1..
database_cross_reference: RXNORM:4986
database_cross_reference: SNMI:C-A1010
database_cross_reference: SNMI:F-B5020
database_cross_reference: SNOMEDCT_US:20577002
database_cross_reference: SNOMEDCT_US:408755005
database_cross_reference: SNOMEDCT_US:59433001
database_cross_reference: USPMG:MTHU001340
database_cross_reference: VANDF:4017617
database_cross_reference: VANDF:4017618

Chorionic Gonadotropin, beta Subunit, Human
type: Class
subclass of: PMO:00024391
subclass of: PMO:00024394
MCID: MC00047765
PMOID: PMO:00019083
Subclass_of: Biomarkers
Subclass_of: Biomarkers, Tumor
Synonym: BHCG - Beta human chorionic gonadotrophin
Synonym: BHCG - Beta human chorionic gonadotropin
Synonym: BHCG-Beta hum chorion gonadotr
Synonym: Beta human chorio gonadotroph
Synonym: Beta human chorionic gonadotrophin
Synonym: Beta human chorionic gonadotropin
Synonym: BhCG - Beta human chorionic gonadotrophin
Synonym: BhCG-Bta hum chorio gonodtroph
Synonym: CG-Beta
Synonym: CG-beta
Tree Number: T6.13.9.5.13
Tree Number: T6.13.9.6
database_cross_reference: CHV:0000016160
database_cross_reference: DRUGBANK:DB00097
database_cross_reference: MSH:D018997
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17479
database_cross_reference: NCI_NCI-GLOSS:CDR0000354453
database_cross_reference: NCI_NCI-GLOSS:CDR0000354454
database_cross_reference: NDFRT:N0000171362
database_cross_reference: RCD:X80Fo
database_cross_reference: SNM:F-27140
database_cross_reference: SNMI:F-B5040
database_cross_reference: SNOMEDCT_US:40940006

Gonadotropins, Equine
type: Class
subclass of: PMO:00023681
MCID: MC00005803
PMOID: PMO:00019084
Subclass_of: Pregnancy Proteins
Synonym: Equine Chorionic Gonadotropin
Synonym: Equine Gonadotropins
Synonym: Equine gonadotropin
Synonym: Gonadotropins, Equine [Chemical/Ingredient]
Synonym: eCG
Tree Number: T6.10.3.42.4
database_cross_reference: MSH:D006064
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C29773
database_cross_reference: NDFRT:N0000170331

Menotropins
type: Class
subclass of: PMO:00024104
MCID: MC00008061
PMOID: PMO:00019090
Subclass_of: Biological Products
Synonym: Gonadotropin, menopausal
Synonym: Gonadotropins, Human Menopausal
Synonym: HMG
Synonym: Human Menopausal Gonadotropin
Synonym: Human Menopausal Gonadotropins
Synonym: Human menopausal gonadotrophin
Synonym: Human menopausal gonadotrophins
Synonym: Human menopausal gonadotrophins (product)
Synonym: Human menopausal gonadotrophins (substance)
Synonym: Human menopausal gonadotropin
Tree Number: T6.12.2.2
database_cross_reference: ATC:G03GA02
database_cross_reference: CHV:0000007950
database_cross_reference: DRUGBANK:DB00032
database_cross_reference: DRUGBANK:DB09126
database_cross_reference: MEDCIN:43333
database_cross_reference: MEDCIN:72101
database_cross_reference: MMSL:5043
database_cross_reference: MMSL:d00571
database_cross_reference: MSH:D008596
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2274
database_cross_reference: NCI:C634
database_cross_reference: NCI_FDA:5Y9QQM372Q
database_cross_reference: NDDF:002103
database_cross_reference: NDFRT:N0000011322
database_cross_reference: PDQ:CDR0000039276
database_cross_reference: RCD:x007X
database_cross_reference: SNMI:C-A1020
database_cross_reference: SNMI:F-B1650
database_cross_reference: SNOMEDCT_US:346565008
database_cross_reference: SNOMEDCT_US:55830003
database_cross_reference: SNOMEDCT_US:8203003

Hypothalamic Hormones
type: Class
subclass of: Peptide Hormones
subclass of: PMO:00021344
MCID: MC00006631
PMOID: PMO:00019093
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: HYPOTHALAMIC HORMONES
Synonym: Hormones, Hypothalamic
Synonym: Hormones, Hypothalamic Pituitary-Regulating
Synonym: Hypothalamic Hormone
Synonym: Hypothalamic Hormones [Chemical/Ingredient]
Synonym: Hypothalamic Pituitary Regulating Hormones
Synonym: Hypothalamic Pituitary Regulating Peptides
Synonym: Hypothalamic Pituitary-Regulating Hormones
Synonym: Hypothalamic Pituitary-Regulating Peptides
Synonym: Hypothalamic hormones
Tree Number: T6.10.2.12.10
Tree Number: T6.10.2.32.6
Tree Number: T6.6.2.8.7
database_cross_reference: ATC:H01C
database_cross_reference: CSP:2334-3186
database_cross_reference: LCH:U002343
database_cross_reference: LCH_NW:sh85063822
database_cross_reference: LNC:LP31656-9
database_cross_reference: MSH:D007028
database_cross_reference: NCI:C2183
database_cross_reference: NDFRT:N0000011270

Gonadotropin-Releasing Hormone
type: Class
subclass of: PMO:00021376
MCID: MC00007549
PMOID: PMO:00019101
Subclass_of: Oligopeptides
Synonym: 5-oxoPro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (human or pig)
Synonym: D-His-6-Pro-8-NEt-LHRH
Synonym: FRF
Synonym: FSH Releasing Hormone
Synonym: FSH-Releasing Hormone
Synonym: FSH-releasing hormone
Synonym: FSH/RF
Synonym: FSHRF preparation
Synonym: FSHRH
Synonym: Factrel Inj 0.5mg/vial
Tree Number: T6.10.2.13.11
database_cross_reference: AOD:0000018753
database_cross_reference: AOD:0000018773
database_cross_reference: AOD:0000018800
database_cross_reference: AOD:0000028392
database_cross_reference: AOD:0000028394
database_cross_reference: AOD:0000028396
database_cross_reference: AOD:0000028436
database_cross_reference: AOD:0000028463
database_cross_reference: AOD:0000028466
database_cross_reference: ATC:H01CA
database_cross_reference: ATC:H01CA01
database_cross_reference: ATC:V04CM01
database_cross_reference: CHV:0000007383
database_cross_reference: CSP:2334-3747
database_cross_reference: DRUGBANK:DB00644
database_cross_reference: FMA:83356
database_cross_reference: LCH_NW:sh85078987
database_cross_reference: LNC:LP16322-7
database_cross_reference: LNC:LP231999-6
database_cross_reference: LNC:LP32557-8
database_cross_reference: LNC:MTHU004297
database_cross_reference: MMSL:d00573
database_cross_reference: MSH:D007987
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9O7312W37G
database_cross_reference: NCI:C2270
database_cross_reference: NCI_NCI-GLOSS:CDR0000044574
database_cross_reference: NCI_NCI-GLOSS:CDR0000045751
database_cross_reference: NCI_NCI-GLOSS:CDR0000306499
database_cross_reference: NCI_NCI-GLOSS:CDR0000306531
database_cross_reference: NDDF:004782
database_cross_reference: NDDF:008305
database_cross_reference: NDFRT:N0000006708
database_cross_reference: NDFRT:N0000147858
database_cross_reference: PDQ:CDR0000040445
database_cross_reference: PDQ:CDR0000042628
database_cross_reference: RCD:X80Fj
database_cross_reference: RCD:fq1..
database_cross_reference: RCD:puf..
database_cross_reference: RCDAE:X80Fj
database_cross_reference: RXNORM:6384
database_cross_reference: SNM:F-25130
database_cross_reference: SNM:F-25140
database_cross_reference: SNM:F-25170
database_cross_reference: SNMI:C-A15C0
database_cross_reference: SNMI:C-A15C2
database_cross_reference: SNMI:C-A15C5
database_cross_reference: SNMI:F-B1040
database_cross_reference: SNMI:F-B1080
database_cross_reference: SNOMEDCT_US:20941000
database_cross_reference: SNOMEDCT_US:32011002
database_cross_reference: SNOMEDCT_US:325995009
database_cross_reference: SNOMEDCT_US:337381005
database_cross_reference: SNOMEDCT_US:397197007
database_cross_reference: SNOMEDCT_US:49869009
database_cross_reference: SNOMEDCT_US:66835004
database_cross_reference: SNOMEDCT_US:75969007
database_cross_reference: VANDF:4019767

Thyrotropin-Releasing Hormone
type: Class
subclass of: PMO:00021376
MCID: MC00012843
PMOID: PMO:00019109
Subclass_of: Oligopeptides
Synonym: 5-oxo-L-prolyl-L-histidyl-L-prolinamide
Synonym: L-pyroglutamyl-L-histidyl-L-prolineamide
Synonym: PROTIRELIN
Synonym: Protirelin
Synonym: Protirelin (product)
Synonym: Protirelin (substance)
Synonym: Protirelin preparation
Synonym: Protirelin preparation (product)
Synonym: Protirelin preparation -RETIRED-
Synonym: Relefact Trh Inj 0.2mg/ml
Tree Number: T6.10.2.13.21
database_cross_reference: AOD:0000018743
database_cross_reference: AOD:0000028380
database_cross_reference: AOD:0000028382
database_cross_reference: ATC:V04CJ02
database_cross_reference: CHV:0000012273
database_cross_reference: CSP:2334-6001
database_cross_reference: DRUGBANK:DB09421
database_cross_reference: FMA:83355
database_cross_reference: LCH_NW:sh85135181
database_cross_reference: LNC:LP32535-4
database_cross_reference: LNC:LP62881-5
database_cross_reference: LNC:MTHU025741
database_cross_reference: MEDCIN:48801
database_cross_reference: MMSL:5380
database_cross_reference: MMSL:d03679
database_cross_reference: MSH:D013973
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5Y5F15120W
database_cross_reference: NCI:C28420
database_cross_reference: NCI:C66495
database_cross_reference: NCI_FDA:5Y5F15120W
database_cross_reference: NDDF:002111
database_cross_reference: NDFRT:N0000146792
database_cross_reference: NDFRT:N0000170390
database_cross_reference: RCD:X80Gd
database_cross_reference: RCD:fq3..
database_cross_reference: RXNORM:10580
database_cross_reference: SNM:E-8618
database_cross_reference: SNM:F-25150
database_cross_reference: SNMI:C-A15E5
database_cross_reference: SNMI:C-A15E8
database_cross_reference: SNMI:F-B1060
database_cross_reference: SNOMEDCT_US:10534002
database_cross_reference: SNOMEDCT_US:29361008
database_cross_reference: SNOMEDCT_US:412494006
database_cross_reference: SNOMEDCT_US:412495007
database_cross_reference: SNOMEDCT_US:412496008
database_cross_reference: SNOMEDCT_US:73805002
database_cross_reference: VANDF:4018469

Pro-Opiomelanocortin
type: Class
subclass of: PMO:00023688
MCID: MC00010631
PMOID: PMO:00019110
Subclass_of: Protein Precursors
Synonym: ACTH Endorphin Precursor
Synonym: ACTH beta Lipotropin Precursor
Synonym: ACTH-Endorphin Precursor
Synonym: ACTH-beta-Lipotropin Precursor
Synonym: Corticotropin beta Lipotropin Precursor
Synonym: Corticotropin-beta-Lipotropin Precursor
Synonym: Endorphin ACTH Precursor
Synonym: Endorphin-ACTH Precursor
Synonym: Opiomelanocortin, pro-
Synonym: POMC
Tree Number: T6.10.3.45.5
database_cross_reference: AOD:0000020499
database_cross_reference: AOD:0000028949
database_cross_reference: AOD:0000028950
database_cross_reference: CHV:0000010131
database_cross_reference: CSP:2334-5463
database_cross_reference: LCH_NW:sh90005378
database_cross_reference: MSH:D011333
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000011375
database_cross_reference: RCD:X80GO
database_cross_reference: SNMI:F-B7250
database_cross_reference: SNOMEDCT_US:80688007

Melanocyte-Stimulating Hormones
type: Class
subclass of: PMO:00021344
MCID: MC00008443
PMOID: PMO:00019121
Subclass_of: Neuropeptides
Synonym: MSH
Synonym: MSH (Melanocyte-Stimulating Hormones)
Synonym: MSH - Melanocyte stim horm
Synonym: MSH - Melanocyte stimulating hormone
Synonym: Melanocyte Stimulating Hormone
Synonym: Melanocyte Stimulating Hormones
Synonym: Melanocyte stimulating hormone
Synonym: Melanocyte stimulating hormone (MSH)
Synonym: Melanocyte stimulating hormone (substance)
Synonym: Melanocyte-Stimulating Hormones [Chemical/Ingredient]
Tree Number: T6.10.2.12.12
database_cross_reference: AOD:0000018765
database_cross_reference: AOD:0000018768
database_cross_reference: AOD:0000028426
database_cross_reference: AOD:0000028429
database_cross_reference: AOD:0000028430
database_cross_reference: AOD:0000028431
database_cross_reference: CHV:0000008298
database_cross_reference: CSP:2334-4308
database_cross_reference: FMA:74643
database_cross_reference: FMA:83361
database_cross_reference: LNC:LP31744-3
database_cross_reference: MSH:D009074
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170377
database_cross_reference: PSY:30535
database_cross_reference: PSY:30537
database_cross_reference: RCD:X80Fv
database_cross_reference: SNM:F-25470
database_cross_reference: SNMI:F-B1510
database_cross_reference: SNOMEDCT_US:46015007
database_cross_reference: UWDA:74643

Inhibins
type: Class
subclass of: Peptide Hormones
subclass of: Gonadal Hormones
subclass of: PMO:00020943
MCID: MC00006863
PMOID: PMO:00019125
Subclass_of: Glycoproteins
Subclass_of: Gonadal Hormones
Subclass_of: Peptide Hormones
Synonym: Folliculostatin
Synonym: INHIBIN
Synonym: Inhibin
Synonym: Inhibin Hormone
Synonym: Inhibin hormone
Synonym: Inhibin hormone (substance)
Synonym: Inhibins [Chemical/Ingredient]
Synonym: hormone inhibin
Synonym: inhibin
Synonym: inhibins
Tree Number: T6.10.2.32.7
Tree Number: T6.10.3.26.12
Tree Number: T6.6.2.8.8
Tree Number: T6.6.2.9.2
database_cross_reference: CHV:0000006731
database_cross_reference: CSP:2586-9372
database_cross_reference: LCH:U002436
database_cross_reference: LCH_NW:sh85066402
database_cross_reference: LNC:LP15665-0
database_cross_reference: LNC:MTHU012011
database_cross_reference: MSH:D007265
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2276
database_cross_reference: NDFRT:N0000170320
database_cross_reference: RCD:X80Fq
database_cross_reference: SNMI:F-B0270
database_cross_reference: SNOMEDCT_US:63326008

Pancreatic Hormones
type: Class
subclass of: Peptide Hormones
MCID: MC00009661
PMOID: PMO:00019127
Subclass_of: Peptide Hormones
Synonym: B60-B63 PANCREATIC HORMONES
Synonym: Hormones, Pancreatic
Synonym: PANCREATIC HORMONES
Synonym: Pancreatic Hormones [Chemical/Ingredient]
Synonym: Pancreatic hormone
Synonym: Pancreatic hormone (substance)
Synonym: Pancreatic hormone preparation
Synonym: Pancreatic hormone preparation (substance)
Synonym: Pancreatic hormone preparation, NOS
Synonym: Pancreatic hormone product
Tree Number: T6.10.2.32.9
Tree Number: T6.6.2.8.10
database_cross_reference: AOD:0000018697
database_cross_reference: ATC:H04
database_cross_reference: CHV:0000009222
database_cross_reference: CSP:2202-0861
database_cross_reference: LNC:LP31657-7
database_cross_reference: MSH:D010187
database_cross_reference: NDFRT:N0000011346
database_cross_reference: SNM:E-8580
database_cross_reference: SNM:F-27300
database_cross_reference: SNM:U000201
database_cross_reference: SNMI:C-A2050
database_cross_reference: SNMI:F-B6000
database_cross_reference: SNOMEDCT_US:26548008
database_cross_reference: SNOMEDCT_US:39933002

Pancreatic Polypeptide
type: Class
subclass of: PMO:00021344
MCID: MC00009665
PMOID: PMO:00019128
Subclass_of: Neuropeptides
Synonym: Human pancreatic polypeptide
Synonym: Interacinar Cell Pancreatic Polypeptide
Synonym: PP
Synonym: PP - Pancreatic polypeptide
Synonym: PPP - Human pancreatic polypeptide
Synonym: PPP - Pancreatic polypeptide
Synonym: PPP-Human pancreat polypeptide
Synonym: Pancreatic Polypeptide (PP)
Synonym: Pancreatic Polypeptide Hormone
Synonym: Pancreatic Polypeptide [Chemical/Ingredient]
Tree Number: T6.10.2.12.16
database_cross_reference: AOD:0000017526
database_cross_reference: CHV:0000009226
database_cross_reference: CSP:2202-2601
database_cross_reference: DRUGBANK:DB12822
database_cross_reference: LNC:LP15770-8
database_cross_reference: LNC:MTHU013006
database_cross_reference: MSH:D010191
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C725
database_cross_reference: NCI_NCI-GLOSS:CDR0000657864
database_cross_reference: NCI_NCI-GLOSS:CDR0000657865
database_cross_reference: NDFRT:N0000170391
database_cross_reference: RCD:X80GA
database_cross_reference: SNM:F-27590
database_cross_reference: SNMI:F-B6040
database_cross_reference: SNOMEDCT_US:35976007
database_cross_reference: SNOMEDCT_US:406509001

Proinsulin
type: Class
subclass of: PMO:00023688
MCID: MC00010675
PMOID: PMO:00019132
Subclass_of: Protein Precursors
Synonym: Proinsulin (substance)
Synonym: Proinsulin [Chemical/Ingredient]
Synonym: proinsulin
Tree Number: T6.10.3.45.7
database_cross_reference: AOD:0000020498
database_cross_reference: CHV:0000010167
database_cross_reference: CSP:2202-1497
database_cross_reference: LCH:U003851
database_cross_reference: LCH_NW:sh85107335
database_cross_reference: LNC:LP14637-0
database_cross_reference: LNC:MTHU001676
database_cross_reference: MSH:D011384
database_cross_reference: MTH:U002192
database_cross_reference: NDFRT:N0000170325
database_cross_reference: RCD:X80GM
database_cross_reference: SNM:F-27320
database_cross_reference: SNMI:F-B6020
database_cross_reference: SNOMEDCT_US:79212006

Biphasic Insulins
type: Class
subclass of: PMO:00024461
MCID: MC00128851
PMOID: PMO:00019144
Subclass_of: Drug Combinations
Synonym: Biphasic Insulin
Synonym: Biphasic Insulins [Chemical/Ingredient]
Synonym: Biphasic insulin
Synonym: Biphasic insulin (substance)
Synonym: Biphasic insulin - chemical
Synonym: Biphasic insulin - chemical (substance)
Synonym: Insulin Mixtures
Synonym: Insulin, Biphasic
Synonym: Insulins, Biphasic
Synonym: Insulins, Mixed
Tree Number: T6.15.3.22
database_cross_reference: MSH:D061265
database_cross_reference: NDFRT:N0000183489
database_cross_reference: RCD:f21..
database_cross_reference: SNOMEDCT_US:325080009
database_cross_reference: SNOMEDCT_US:391849003

Parathyroid Hormone
type: Class
subclass of: Peptide Hormones
MCID: MC00006402
PMOID: PMO:00019148
Subclass_of: Peptide Hormones
Synonym: PTH
Synonym: PTH protein, human
Synonym: Parathormone
Synonym: Parathyrin
Synonym: hPTH
Synonym: hPTH(1-84)
Synonym: parathormone
Synonym: parathyrin
Synonym: parathyroid hormone
Synonym: parathyroid hormone, human
Tree Number: T6.10.2.32.10
Tree Number: T6.6.2.8.11
database_cross_reference: DRUGBANK:DB05829
database_cross_reference: MSH:C470125
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C41027
database_cross_reference: NCI_NCI-GLOSS:CDR0000044339
database_cross_reference: NCI_NCI-GLOSS:CDR0000403137
database_cross_reference: NCI_NCI-GLOSS:CDR0000403138
database_cross_reference: PDQ:CDR0000489119

Peptide PHI
type: Class
subclass of: Peptide Hormones
subclass of: PMO:00021344
MCID: MC00009869
PMOID: PMO:00019150
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: Histidine Methionine, Peptide
Synonym: Histidine-Isoleucine, Peptide
Synonym: Intestinal Peptide, Pro-Vasoactive
Synonym: Methionine, Peptide Histidine
Synonym: Neuropeptide PHI 27
Synonym: Neuropeptide, PHM
Synonym: PHI Peptide
Synonym: PHM Neuropeptide
Synonym: PHM, Peptide
Synonym: PHM-27
Tree Number: T6.10.2.12.17
Tree Number: T6.10.2.32.11
Tree Number: T6.6.2.8.12
database_cross_reference: LNC:LP18577-4
database_cross_reference: LNC:MTHU004688
database_cross_reference: MSH:D010451
database_cross_reference: NDFRT:N0000170384

Pituitary Hormones
type: Class
subclass of: Peptide Hormones
MCID: MC00010261
PMOID: PMO:00019151
Subclass_of: Peptide Hormones
Synonym: Hormones, Pituitary
Synonym: Pituitary Hormone
Synonym: Pituitary Hormones [Chemical/Ingredient]
Synonym: Pituitary hormone
Synonym: Pituitary hormone (substance)
Synonym: Pituitary hormone, NOS
Synonym: Pituitary hormones
Synonym: hypophysial hormone
Synonym: pituitary hormone
Synonym: pituitary hormones
Tree Number: T6.10.2.32.12
Tree Number: T6.6.2.8.13
database_cross_reference: AOD:0000018711
database_cross_reference: AOD:0000028362
database_cross_reference: CHV:0000009764
database_cross_reference: CSP:2334-5253
database_cross_reference: LCH:U003691
database_cross_reference: LCH_NW:sh85102529
database_cross_reference: LNC:LP31660-1
database_cross_reference: MSH:D010907
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C752
database_cross_reference: NDFRT:N0000011201
database_cross_reference: PSY:38980
database_cross_reference: RCD:XaDpe
database_cross_reference: SNMI:F-B1400
database_cross_reference: SNOMEDCT_US:312270009
database_cross_reference: SNOMEDCT_US:84746004

Vasopressins
type: Class
subclass of: PMO:00021344
subclass of: PMO:00021376
MCID: MC00013502
PMOID: PMO:00019161
Subclass_of: Neuropeptides
Subclass_of: Oligopeptides
Synonym: ADH
Synonym: Antidiuretic Hormones
Synonym: Vasopressins [Chemical/Ingredient]
Synonym: adh vasopressin
Synonym: adhs
Synonym: antidiuretic hormone
Synonym: antidiuretic hormones
Synonym: beta Hypophamine
Synonym: beta-Hypophamine
Synonym: vasopressin
Tree Number: T6.10.2.12.20
Tree Number: T6.10.2.13.23
database_cross_reference: CHV:0000012922
database_cross_reference: MSH:D014667
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000006320

Placental Hormones
type: Class
subclass of: Peptide Hormones
MCID: MC00010276
PMOID: PMO:00019168
Subclass_of: Peptide Hormones
Synonym: B5 PLACENTAL HORMONES
Synonym: Hormones, Placental
Synonym: PLACENTAL HORMONES
Synonym: Placental Hormones [Chemical/Ingredient]
Synonym: Placental hormone
Synonym: Placental hormone (substance)
Synonym: Placental hormone, NOS
Synonym: Placental hormones
Synonym: placental hormone
Synonym: placental hormones
Tree Number: T6.10.2.32.13
Tree Number: T6.6.2.8.14
database_cross_reference: AOD:0000018705
database_cross_reference: CHV:0000009783
database_cross_reference: CSP:2586-9420
database_cross_reference: LCH:U003697
database_cross_reference: LCH_NW:sh85102573
database_cross_reference: MSH:D010926
database_cross_reference: NDFRT:N0000011265
database_cross_reference: SNM:F-27100
database_cross_reference: SNM:U000200
database_cross_reference: SNMI:F-B5000
database_cross_reference: SNOMEDCT_US:42056007

Placental Lactogen
type: Class
subclass of: PMO:00023681
MCID: MC00447051
PMOID: PMO:00019169
Subclass_of: Pregnancy Proteins
Synonym: CGHP
Synonym: Choriomammotrophin
Synonym: Choriomammotropin
Synonym: Chorionic Somatomammotropin
Synonym: Chorionic somatomammotrophin
Synonym: Lactogen Hormone, Placental
Synonym: Lactogen, Placental
Synonym: Lactogen, placental
Synonym: Luteotropin, Placental
Synonym: Mammotropic Hormone, Placental
Tree Number: T6.10.3.42.5
database_cross_reference: CHV:0000058015
database_cross_reference: CSP:2586-9141
database_cross_reference: FMA:83363
database_cross_reference: LNC:LP15498-6
database_cross_reference: LNC:MTHU009439
database_cross_reference: MSH:D010928
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170330
database_cross_reference: RCD:X80Fp
database_cross_reference: SNOMEDCT_US:143772000
database_cross_reference: SNOMEDCT_US:166429006
database_cross_reference: SNOMEDCT_US:54188006

Relaxin
type: Class
subclass of: Peptide Hormones
MCID: MC00011243
PMOID: PMO:00019170
Subclass_of: Peptide Hormones
Synonym: Relaxin (substance)
Synonym: Relaxin [Chemical/Ingredient]
Synonym: relaxin
Tree Number: T6.10.2.32.14
Tree Number: T6.6.2.8.15
database_cross_reference: CHV:0000010707
database_cross_reference: CSP:2586-9513
database_cross_reference: LCH:U004077
database_cross_reference: LCH_NW:sh85112505
database_cross_reference: MSH:D012065
database_cross_reference: NDFRT:N0000170324
database_cross_reference: RCD:X80GP
database_cross_reference: RXNORM:9238
database_cross_reference: SNMI:F-B2580
database_cross_reference: SNOMEDCT_US:35466004

Urotensins
type: Class
subclass of: Peptide Hormones
MCID: MC00013405
PMOID: PMO:00019171
Subclass_of: Peptide Hormones
Synonym: Urotensins [Chemical/Ingredient]
Tree Number: T6.10.2.32.17
Tree Number: T6.6.2.8.17
database_cross_reference: MSH:D014579
database_cross_reference: NDFRT:N0000171056

Activins
type: Class
subclass of: Peptide Hormones
subclass of: Gonadal Hormones
subclass of: PMO:00020943
MCID: MC00019223
PMOID: PMO:00019172
Subclass_of: Glycoproteins
Subclass_of: Gonadal Hormones
Subclass_of: Peptide Hormones
Synonym: Activin
Synonym: Activin hormone
Synonym: Activin hormone (substance)
Synonym: Activins [Chemical/Ingredient]
Synonym: FSH Releasing Protein
Synonym: FSH-Releasing Protein
Synonym: Protein, FSH-Releasing
Synonym: activin
Synonym: activins
Tree Number: T6.10.2.32.20
Tree Number: T6.10.3.26.27
Tree Number: T6.6.2.8.20
Tree Number: T6.6.2.9.5
database_cross_reference: CHV:0000013429
database_cross_reference: CSP:5003-0002
database_cross_reference: LCH_NW:sh97005108
database_cross_reference: MSH:D028341
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C20456
database_cross_reference: NDFRT:N0000170322
database_cross_reference: SNMI:F-B0280
database_cross_reference: SNOMEDCT_US:30145004

Parathyroid Hormone-Related Protein
type: Class
subclass of: Peptide Hormones
subclass of: PMO:00021462
MCID: MC00034311
PMOID: PMO:00019173
Subclass_of: Intercellular Signaling Peptides and Proteins
Subclass_of: Peptide Hormones
Synonym: Hormone-Related Protein, Parathyroid
Synonym: Hypercalcemic Factor, Tumor
Synonym: Hypercalcemic Hormone of Malignancy
Synonym: PARATHYROID HORMONE RELAT PEPTIDE
Synonym: PARATHYROID HORMONE RELAT PROTEIN
Synonym: PTH Like Protein
Synonym: PTH Like Tumor Factor
Synonym: PTH RELAT PEPTIDE
Synonym: PTH Related Peptide
Synonym: PTH-Like Protein
Tree Number: T6.10.2.31.15
Tree Number: T6.10.2.32.21
Tree Number: T6.10.3.83.13
Tree Number: T6.13.12.15
Tree Number: T6.6.2.8.21
database_cross_reference: CHV:0000014580
database_cross_reference: CSP:4006-0073
database_cross_reference: LCH_NW:sh91006183
database_cross_reference: LNC:LP15776-5
database_cross_reference: LNC:MTHU004758
database_cross_reference: MSH:D044162
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170963
database_cross_reference: RCD:X80GF
database_cross_reference: SNMI:F-B3430
database_cross_reference: SNOMEDCT_US:112117005

Natriuretic Peptides
type: Class
subclass of: Peptide Hormones
MCID: MC00382414
PMOID: PMO:00019174
Subclass_of: Peptide Hormones
Synonym: Natriuretic Peptide Hormones
Synonym: Natriuretic Peptides [Chemical/Ingredient]
Synonym: Peptide Hormones, Natriuretic
Synonym: Peptides, Natriuretic
Synonym: natriuretic peptide
Synonym: natriuretic peptide hormone
Synonym: natriuretic peptides
Synonym: peptide natriuretic
Tree Number: T6.10.2.32.22
Tree Number: T6.6.2.8.22
database_cross_reference: CHV:0000055198
database_cross_reference: MSH:D045265
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000011465

Natriuretic Peptide, Brain
type: Class
subclass of: PMO:00023612
MCID: MC00021807
PMOID: PMO:00019176
Subclass_of: Nerve Tissue Proteins
Synonym: 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane, Cyclic Peptide Derivative
Synonym: B-Type Natriuretic Peptide
Synonym: B-type natriuretic peptide
Synonym: BNP
Synonym: BNP 32
Synonym: BNP Gene Product
Synonym: BNP(1-32)
Synonym: BNP-32
Synonym: Brain Natriuretic Peptide
Synonym: Brain Natriuretic Peptide 32
Tree Number: T6.10.3.35.20
database_cross_reference: ATC:C01DX19
database_cross_reference: CHV:0000013613
database_cross_reference: DRUGBANK:DB04899
database_cross_reference: MEDCIN:195922
database_cross_reference: MMSL:16114
database_cross_reference: MMSL:d04763
database_cross_reference: MSH:D020097
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:P7WI8UL647
database_cross_reference: NCI:C47636
database_cross_reference: NCI:C88523
database_cross_reference: NCI_FDA:P7WI8UL647
database_cross_reference: NDDF:009299
database_cross_reference: NDDF:009300
database_cross_reference: NDFRT:N0000010147
database_cross_reference: NDFRT:N0000022235
database_cross_reference: PDQ:CDR0000434520
database_cross_reference: RXNORM:19666
database_cross_reference: SNOMEDCT_US:385677001
database_cross_reference: SNOMEDCT_US:385678006
database_cross_reference: SNOMEDCT_US:385679003
database_cross_reference: SNOMEDCT_US:385680000
database_cross_reference: SNOMEDCT_US:407059007
database_cross_reference: VANDF:4024230

Adrenomedullin
type: Class
subclass of: Peptide Hormones
MCID: MC00069666
PMOID: PMO:00019178
Subclass_of: Peptide Hormones
Synonym: ADM
Synonym: ADM (1-52)
Synonym: ADM Precursor
Synonym: ADM(1-52)
Synonym: Adrenomedullin (1-52)
Synonym: Adrenomedullin [Chemical/Ingredient]
Synonym: PreproAM
Synonym: Preproadrenomedullin
Synonym: ProAM
Synonym: adrenomedullin
Tree Number: T6.10.2.32.23
Tree Number: T6.6.2.8.23
database_cross_reference: CSP:0570-4361
database_cross_reference: CSP:1025-7446
database_cross_reference: LCH_NW:sh99004439
database_cross_reference: MSH:D053607
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C113266
database_cross_reference: NDFRT:N0000175134

Adipokines
type: Class
subclass of: Peptide Hormones
subclass of: PMO:00021462
MCID: MC00628724
PMOID: PMO:00019179
Subclass_of: Intercellular Signaling Peptides and Proteins
Subclass_of: Peptide Hormones
Synonym: Adipocytokine
Synonym: Adipocytokines
Synonym: Adipokine
Synonym: Adipokines [Chemical/Ingredient]
Tree Number: T6.10.2.31.20
Tree Number: T6.10.2.32.24
Tree Number: T6.10.3.83.19
Tree Number: T6.13.12.20
Tree Number: T6.6.2.8.24
database_cross_reference: MSH:D054392
database_cross_reference: NCI:C123810
database_cross_reference: NDFRT:N0000178768

Leptin
type: Class
subclass of: Adipokines
MCID: MC00104889
PMOID: PMO:00019180
Subclass_of: Adipokines
Synonym: Gene Product, Ob
Synonym: Gene Product, Obese
Synonym: Leptin (substance)
Synonym: Leptin [Chemical/Ingredient]
Synonym: Ob Gene Product
Synonym: Ob Protein
Synonym: Obese Gene Product
Synonym: Obese Protein
Synonym: Obesity Factor
Synonym: leptin
Tree Number: T6.13.12.20.1
database_cross_reference: CHV:0000027803
database_cross_reference: CSP:4008-0059
database_cross_reference: DRUGBANK:DB05098
database_cross_reference: LCH_NW:sh99005469
database_cross_reference: LNC:LP19488-3
database_cross_reference: LNC:MTHU009760
database_cross_reference: MSH:D020738
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C46081
database_cross_reference: NDFRT:N0000170333
database_cross_reference: PSY:28182
database_cross_reference: RXNORM:1441651
database_cross_reference: SNOMEDCT_US:414601001

Adiponectin
type: Class
subclass of: Adipokines
MCID: MC00138054
PMOID: PMO:00019181
Subclass_of: Adipokines
Synonym: ACRP30 Protein
Synonym: Adipocyte Complement Related Protein 30 kDa
Synonym: Adipocyte Complement-Related Protein 30-kDa
Synonym: Adipocyte, C1q and Collagen Domain Containing Protein
Synonym: Adiponectin (substance)
Synonym: Adiponectin [Chemical/Ingredient]
Synonym: Adipose Most Abundant Gene Transcript 1
Synonym: adiponectin
Synonym: apM 1 Protein
Synonym: apM-1 Protein
Tree Number: T6.13.12.20.2
database_cross_reference: CHV:0000031958
database_cross_reference: CSP:5006-0001
database_cross_reference: LNC:LP61813-9
database_cross_reference: LNC:MTHU025303
database_cross_reference: MSH:D052242
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170337
database_cross_reference: SNOMEDCT_US:413451007

Resistin
type: Class
subclass of: Adipokines
MCID: MC00349726
PMOID: PMO:00019182
Subclass_of: Adipokines
Synonym: Adipocyte Cysteine Rich Secreted Protein FIZZ3
Synonym: Adipocyte Cysteine-Rich Secreted Protein FIZZ3
Synonym: Resistin (substance)
Synonym: Resistin [Chemical/Ingredient]
Synonym: resistin
Tree Number: T6.13.12.20.3
database_cross_reference: CHV:0000053582
database_cross_reference: LNC:LP185757-4
database_cross_reference: LNC:MTHU048271
database_cross_reference: MSH:D052243
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170329
database_cross_reference: SNOMEDCT_US:415292004

Ghrelin
type: Class
subclass of: Peptide Hormones
MCID: MC00318494
PMOID: PMO:00019183
Subclass_of: Peptide Hormones
Synonym: Gherlin
Synonym: Gherlin (substance)
Synonym: Ghrelin (substance)
Synonym: Ghrelin [Chemical/Ingredient]
Synonym: Lenomorelin
Synonym: ghrelin
Tree Number: T6.10.2.32.25
Tree Number: T6.6.2.8.25
database_cross_reference: CHV:0000052310
database_cross_reference: CSP:5005-0010
database_cross_reference: DRUGBANK:DB11895
database_cross_reference: LCH_NW:sh2004000537
database_cross_reference: LNC:LP189445-2
database_cross_reference: LNC:MTHU048837
database_cross_reference: MSH:D054439
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178700
database_cross_reference: SNOMEDCT_US:414340004

Urocortins
type: Class
subclass of: Peptide Hormones
subclass of: PMO:00021344
MCID: MC00135877
PMOID: PMO:00019184
Subclass_of: Neuropeptides
Subclass_of: Peptide Hormones
Synonym: Urocortins [Chemical/Ingredient]
Synonym: urocortin
Tree Number: T6.10.2.12.30
Tree Number: T6.10.2.32.26
Tree Number: T6.6.2.8.26
database_cross_reference: MSH:D054832
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178651

Gonadal Hormones
type: Class
subclass of: Hormones
MCID: MC00106041
PMOID: PMO:00019185
Subclass_of: Hormones
Synonym: Gonadal Hormones [Chemical/Ingredient]
Synonym: Gonadal hormone
Synonym: Gonadal hormone (substance)
Synonym: Gonadal hormone, NOS
Synonym: Hormones, Gonadal
Synonym: gonadal hormone
Synonym: gonadal hormones
Tree Number: T6.6.2.9
database_cross_reference: CHV:0000027894
database_cross_reference: MSH:D042341
database_cross_reference: NDFRT:N0000011300
database_cross_reference: SNM:F-25050
database_cross_reference: SNMI:F-B2020
database_cross_reference: SNOMEDCT_US:81118006

Corpus Luteum Hormones
type: Class
subclass of: Gonadal Hormones
MCID: MC00003288
PMOID: PMO:00019186
Subclass_of: Gonadal Hormones
Synonym: Corpus Luteum Hormones [Chemical/Ingredient]
Synonym: Corpus luteum hormone
Synonym: Corpus luteum hormone (substance)
Synonym: Hormones, Corpus Luteum
Synonym: Luteum Hormones, Corpus
Synonym: corpus luteum hormones
Synonym: corpus luteum hormones (medication)
Tree Number: T6.6.2.9.1
database_cross_reference: MEDCIN:40969
database_cross_reference: MSH:D003339
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000011299
database_cross_reference: SNOMEDCT_US:126122008

Gonadal Steroid Hormones
type: Class
subclass of: Gonadal Hormones
MCID: MC00011803
PMOID: PMO:00019187
Subclass_of: Gonadal Hormones
Synonym: Gonadal Steroid Hormones [Chemical/Ingredient]
Synonym: Hormones, Gonadal Steroid
Synonym: Hormones, Sex
Synonym: Hormones, Sex Steroid
Synonym: Sex Hormone
Synonym: Sex Hormones
Synonym: Sex Steroid
Synonym: Sex Steroid Hormone
Synonym: Sex Steroid Hormones
Synonym: Sex hormone
Tree Number: T6.6.2.9.3
database_cross_reference: AOD:0000018699
database_cross_reference: AOD:0000028356
database_cross_reference: CHV:0000011271
database_cross_reference: CSP:2586-9606
database_cross_reference: LCH_NW:sh85061983
database_cross_reference: MSH:D012739
database_cross_reference: NCI:C123796
database_cross_reference: NDFRT:N0000011302
database_cross_reference: PSY:46900
database_cross_reference: RCD:XaDpT
database_cross_reference: RCD:x00Al
database_cross_reference: SNOMEDCT_US:312263009
database_cross_reference: SNOMEDCT_US:346674004

Testicular Hormones
type: Class
subclass of: Gonadal Hormones
MCID: MC00012626
PMOID: PMO:00019194
Subclass_of: Gonadal Hormones
Synonym: Hormones, Testicular
Synonym: Testicular Hormones [Chemical/Ingredient]
Synonym: Testicular hormone
Synonym: Testicular hormone (substance)
Synonym: Testicular hormone, NOS
Tree Number: T6.6.2.9.4
database_cross_reference: MSH:D013735
database_cross_reference: NDFRT:N0000167500
database_cross_reference: SNM:F-25060
database_cross_reference: SNMI:F-B0110
database_cross_reference: SNOMEDCT_US:35060001

Enzymes and Coenzymes
type: Class
subclass of: Chemical and Drug
MCID: MC00421739
PMOID: PMO:00019196
Subclass_of: Chemical and Drug
Synonym: Coenzymes and Enzymes
Synonym: Enzymes and Coenzymes [Chemical/Ingredient]
Synonym: coenzymes enzymes
Synonym: enzymes and coenzymes
Tree Number: T6.7
database_cross_reference: CHV:0000056303
database_cross_reference: MSH:D045762
database_cross_reference: NDFRT:N0000011388

Coenzymes
type: Class
subclass of: Enzymes and Coenzymes
MCID: MC00003043
PMOID: PMO:00019197
Subclass_of: Enzymes and Coenzymes
Synonym: Coenzyme
Synonym: Coenzyme (substance)
Synonym: Coenzymes [Chemical/Ingredient]
Synonym: Cofactors, Enzyme
Synonym: Enzyme Cofactors
Synonym: coenzyme
Synonym: coenzyme analog
Synonym: coenzymes
Tree Number: T6.7.1
database_cross_reference: AOD:0000018582
database_cross_reference: CHV:0000003130
database_cross_reference: CSP:0703-4988
database_cross_reference: CSP:0704-2480
database_cross_reference: LCH:U001081
database_cross_reference: LCH_NW:sh85027690
database_cross_reference: MSH:D003067
database_cross_reference: NDFRT:N0000007666
database_cross_reference: SNM:F-20900
database_cross_reference: SNOMEDCT_US:129913005

Sphingolipid Activator Proteins
type: Class
subclass of: Coenzymes
MCID: MC00510882
PMOID: PMO:00019198
Subclass_of: Coenzymes
Synonym: Sphingolipid Activator Proteins [Chemical/Ingredient]
Tree Number: T6.7.1.14
database_cross_reference: MSH:D049128
database_cross_reference: NDFRT:N0000168394

Saposins
type: Class
subclass of: Sphingolipid Activator Proteins
MCID: MC00038980
PMOID: PMO:00019199
Subclass_of: Sphingolipid Activator Proteins
Synonym: Saposins [Chemical/Ingredient]
Synonym: Testibumin
Tree Number: T6.7.1.14.1
database_cross_reference: MSH:D049231
database_cross_reference: NDFRT:N0000168395

G(M2) Activator Protein
type: Class
subclass of: Sphingolipid Activator Proteins
MCID: MC00027931
PMOID: PMO:00019200
Subclass_of: Sphingolipid Activator Proteins
Synonym: Activator Protein, GM2
Synonym: G(M2) Activator Protein [Chemical/Ingredient]
Synonym: GM ACTIVATOR PROTEIN 02
Synonym: GM(2) Activating Protein
Synonym: GM2 Activator Protein
Synonym: Hexosaminidase Activator
Tree Number: T6.7.1.14.2
database_cross_reference: MSH:D049289
database_cross_reference: NDFRT:N0000168396

Cytochromes
type: Class
subclass of: Enzymes and Coenzymes
subclass of: PMO:00023049
MCID: MC00003501
PMOID: PMO:00019201
Subclass_of: Enzymes and Coenzymes
Subclass_of: Hemeproteins
Synonym: Cytochrome
Synonym: Cytochromes [Chemical/Ingredient]
Synonym: cytochrome
Synonym: cytochromes
Tree Number: T6.10.3.27.1
Tree Number: T6.7.2
database_cross_reference: AOD:0000018501
database_cross_reference: CHV:0000003578
database_cross_reference: CSP:1418-4617
database_cross_reference: LCH_NW:sh87005369
database_cross_reference: LNC:LP36411-4
database_cross_reference: MSH:D003580
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16486
database_cross_reference: NDFRT:N0000170014

Cytochrome b Group
type: Class
subclass of: Cytochromes
MCID: MC00420880
PMOID: PMO:00019202
Subclass_of: Cytochromes
Synonym: Cytochrome b Group [Chemical/Ingredient]
Synonym: Cytochromes Type b
Synonym: Cytochromes, Heme b
Synonym: Group, Cytochrome b
Synonym: Heme b Cytochromes
Synonym: Type b, Cytochromes
Synonym: b Cytochromes, Heme
Synonym: b Group, Cytochrome
Tree Number: T6.7.2.1
database_cross_reference: MSH:D003573
database_cross_reference: NDFRT:N0000170025

Cytochromes b5
type: Class
subclass of: Cytochrome b Group
MCID: MC00003492
PMOID: PMO:00019203
Subclass_of: Cytochrome b Group
Synonym: CYTOCHROMES B 05
Synonym: Cytochrome b 5
Synonym: Cytochrome b-5
Synonym: Cytochrome b5
Synonym: Cytochromes b5 [Chemical/Ingredient]
Synonym: Ferricytochrome b5
Synonym: cytochrome b5
Tree Number: T6.7.2.1.1
database_cross_reference: CHV:0000003572
database_cross_reference: MSH:D015786
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170026

Cytochromes b
type: Class
subclass of: Cytochrome b Group
MCID: MC00003491
PMOID: PMO:00019204
Subclass_of: Cytochrome b Group
Synonym: Cytochrome b
Synonym: Cytochromes b [Chemical/Ingredient]
Synonym: cytochrome B
Synonym: cytochrome b
Tree Number: T6.7.2.1.2
database_cross_reference: AOD:0000018592
database_cross_reference: CSP:1418-4721
database_cross_reference: LCH_NW:sh94006755
database_cross_reference: MSH:D045303
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170027

Cytochrome c Group
type: Class
subclass of: Cytochromes
MCID: MC00420881
PMOID: PMO:00019205
Subclass_of: Cytochromes
Synonym: Cytochrome c Group [Chemical/Ingredient]
Synonym: Cytochromes Type c
Synonym: Group, Cytochrome c
Synonym: Type c, Cytochromes
Tree Number: T6.7.2.2
database_cross_reference: MSH:D003574
database_cross_reference: NDFRT:N0000170015

Cytochromes c1
type: Class
subclass of: Cytochrome c Group
MCID: MC00003495
PMOID: PMO:00019206
Subclass_of: Cytochrome c Group
Synonym: CYTOCHROME C01
Synonym: Cytochrome c 1
Synonym: Cytochrome c-1
Synonym: Cytochrome c1
Synonym: Cytochromes c1 [Chemical/Ingredient]
Tree Number: T6.7.2.2.1
database_cross_reference: MSH:D003575
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170018

Cytochromes c
type: Class
subclass of: Cytochrome c Group
MCID: MC00003493
PMOID: PMO:00019207
Subclass_of: Cytochrome c Group
Synonym: Cytochrome c
Synonym: Cytochromes c [Chemical/Ingredient]
Synonym: Ferricytochrome c
Synonym: Ferrocytochrome c
Synonym: cytochrome C
Synonym: cytochrome c
Synonym: ferricytochrome C
Synonym: ferrocytochrome C
Tree Number: T6.7.2.2.2
database_cross_reference: AOD:0000018593
database_cross_reference: AOD:0000028326
database_cross_reference: AOD:0000028328
database_cross_reference: CHV:0000003573
database_cross_reference: CSP:1418-4825
database_cross_reference: LCH:U001251
database_cross_reference: LCH_NW:sh85035230
database_cross_reference: MSH:D045304
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:006176
database_cross_reference: NDFRT:N0000170017

Cytochromes c'
type: Class
subclass of: Cytochrome c Group
MCID: MC00003494
PMOID: PMO:00019208
Subclass_of: Cytochrome c Group
Synonym: CYTOCHROMES C0
Synonym: Cytochrome c'
Synonym: Cytochromes c Prime
Synonym: Cytochromes c' [Chemical/Ingredient]
Synonym: Ferricytochrome c'
Tree Number: T6.7.2.2.3
database_cross_reference: MSH:D045305
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170019

Cytochromes c2
type: Class
subclass of: Cytochrome c Group
MCID: MC00024090
PMOID: PMO:00019209
Subclass_of: Cytochrome c Group
Synonym: Cytochrome C 2
Synonym: Cytochrome C-2
Synonym: Cytochrome c2
Synonym: Cytochromes c2 [Chemical/Ingredient]
Synonym: Ferrocytochrome c2
Tree Number: T6.7.2.2.4
database_cross_reference: MSH:D045362
database_cross_reference: NDFRT:N0000170020

Cytochromes c6
type: Class
subclass of: Cytochrome c Group
MCID: MC00049130
PMOID: PMO:00019210
Subclass_of: Cytochrome c Group
Synonym: Cytochrome c6
Synonym: Cytochromes c6 [Chemical/Ingredient]
Synonym: cytochrome c6
Tree Number: T6.7.2.2.5
database_cross_reference: CSP:1418-4617
database_cross_reference: MSH:D045365
database_cross_reference: NDFRT:N0000170016

Cytochrome P-450 Enzyme System
type: Class
subclass of: Cytochromes
MCID: MC00003497
PMOID: PMO:00019211
Subclass_of: Cytochromes
Synonym: CYP
Synonym: CYP (cytochrome P450)
Synonym: CYP450
Synonym: CYP450 Family
Synonym: CYP450 Superfamily
Synonym: CYTOCHROME P 450
Synonym: CYTOCHROME P 450 ENZYME SYSTEM
Synonym: Cytochrome P 450
Synonym: Cytochrome P 450 Enzyme System
Synonym: Cytochrome P 450 Enzymes
Tree Number: T6.7.2.3
database_cross_reference: AOD:0000018595
database_cross_reference: CHV:0000003575
database_cross_reference: CSP:1418-4903
database_cross_reference: LCH:U001250
database_cross_reference: LCH_NW:sh85035233
database_cross_reference: MSH:D003577
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16484
database_cross_reference: NCI_NCI-GLOSS:CDR0000390266
database_cross_reference: NDFRT:N0000170028
database_cross_reference: SNOMEDCT_US:424446007

Cytochrome P450 Family 1
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054803
PMOID: PMO:00019212
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP1 Enzymes
Synonym: CYP1 Family
Synonym: Cytochrome P450 Family 1 [Chemical/Ingredient]
Tree Number: T6.7.2.3.1
database_cross_reference: MSH:D000072461
database_cross_reference: NDFRT:N0000193124

Cytochrome P450 Family 2
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054802
PMOID: PMO:00019216
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP2 Enzymes
Synonym: CYP2 Family
Synonym: Cytochrome P450 Family 2 [Chemical/Ingredient]
Tree Number: T6.7.2.3.2
database_cross_reference: MSH:D000072467
database_cross_reference: NDFRT:N0000193123

Cytochrome P450 Family 3
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054801
PMOID: PMO:00019226
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP3 Enzymes
Synonym: CYP3 Family
Synonym: Cytochrome P450 Family 3 [Chemical/Ingredient]
Tree Number: T6.7.2.3.3
database_cross_reference: MSH:D000072469
database_cross_reference: NDFRT:N0000193122

Cytochrome P450 Family 4
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054800
PMOID: PMO:00019228
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP4 Enzymes
Synonym: CYP4 Family
Synonym: Cytochrome P450 Family 4 [Chemical/Ingredient]
Tree Number: T6.7.2.3.4
database_cross_reference: MSH:D000072470
database_cross_reference: NDFRT:N0000193121

Cytochrome P450 Family 6
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054799
PMOID: PMO:00019230
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP6 Enzymes
Synonym: CYP6 Family
Synonym: Cytochrome P450 Family 6 [Chemical/Ingredient]
Tree Number: T6.7.2.3.5
database_cross_reference: MSH:D000072472
database_cross_reference: NDFRT:N0000193120

Cytochrome P450 Family 7
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054798
PMOID: PMO:00019231
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP7 Enzymes
Synonym: CYP7 Family
Synonym: Cytochrome P450 Family 7 [Chemical/Ingredient]
Tree Number: T6.7.2.3.6
database_cross_reference: MSH:D000072474
database_cross_reference: NDFRT:N0000193119

Cytochrome P450 Family 8
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054797
PMOID: PMO:00019233
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP8 Enzymes
Synonym: CYP8 Family
Synonym: Cytochrome P450 Family 8 [Chemical/Ingredient]
Tree Number: T6.7.2.3.7
database_cross_reference: MSH:D000072475
database_cross_reference: NDFRT:N0000193118

Cytochrome P450 Family 11
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC00996081
PMOID: PMO:00019235
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP11
Synonym: CYP11 Enzymes
Synonym: CYP11 Family
Synonym: CYPXI
Synonym: Cytochrome P450 11
Synonym: Cytochrome P450 11, Mitochondrial
Synonym: Cytochrome P450 Family 11 [Chemical/Ingredient]
Synonym: Cytochrome P450 Subfamily XI
Synonym: Cytochrome P450, Family 11
Synonym: Mitochondrial Cytochrome P450 11
Tree Number: T6.7.2.3.8
database_cross_reference: MSH:D000072476
database_cross_reference: NCI:C116407
database_cross_reference: NDFRT:N0000193032

Cytochrome P450 Family 12
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054796
PMOID: PMO:00019239
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP12 Enzymes
Synonym: CYP12 Family
Synonym: Cytochrome P450 Family 12 [Chemical/Ingredient]
Tree Number: T6.7.2.3.9
database_cross_reference: MSH:D000072477
database_cross_reference: NDFRT:N0000193117

Cytochrome P450 Family 17
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC00012226
PMOID: PMO:00019240
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: 17 alpha Hydroxylase
Synonym: 17 alpha Hydroxylase Cytochrome P 450
Synonym: 17 alpha hydroxylase
Synonym: 17 alpha-Hydroxylase
Synonym: 17 alpha-Hydroxylase Cytochrome P-450
Synonym: 17 alpha-Hydroxylase, Steroid
Synonym: 17 alpha-Monooxygenase, Steroid
Synonym: 17 hydroxylase
Synonym: 17,20 Desmolase
Synonym: 17,20 Lyase
Tree Number: T6.7.2.3.10
database_cross_reference: CHV:0000011728
database_cross_reference: CSP:2192-3650
database_cross_reference: MSH:D013254
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C40068
database_cross_reference: NDFRT:N0000170031
database_cross_reference: PDQ:CDR0000322851
database_cross_reference: RCD:X80MQ
database_cross_reference: SNM:F-21060
database_cross_reference: SNM:F-21860
database_cross_reference: SNMI:F-67480
database_cross_reference: SNOMEDCT_US:74032003

Cytochrome P450 Family 19
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054795
PMOID: PMO:00019242
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP19 Enzymes
Synonym: CYP19 Family
Synonym: Cytochrome P450 Family 19 [Chemical/Ingredient]
Tree Number: T6.7.2.3.11
database_cross_reference: MSH:D000072496
database_cross_reference: NDFRT:N0000193116

Cytochrome P450 Family 21
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054794
PMOID: PMO:00019244
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP21 Enzymes
Synonym: CYP21 Family
Synonym: Cytochrome P450 Family 21 [Chemical/Ingredient]
Tree Number: T6.7.2.3.12
database_cross_reference: MSH:D000072497
database_cross_reference: NDFRT:N0000193115

Cytochrome P450 Family 24
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054793
PMOID: PMO:00019246
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP24 Enzymes
Synonym: CYP24 Family
Synonym: Cytochrome P450 Family 24 [Chemical/Ingredient]
Tree Number: T6.7.2.3.13
database_cross_reference: MSH:D000072498
database_cross_reference: NDFRT:N0000193114

Cytochrome P450 Family 26
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054792
PMOID: PMO:00019248
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP26 Cytochrome P450
Synonym: CYP26 Enzymes
Synonym: CYP26 Family
Synonym: Cytochrome P 450 CYP26
Synonym: Cytochrome P-450 CYP26
Synonym: Cytochrome P450 Family 26 [Chemical/Ingredient]
Synonym: Cytochrome P450, CYP26
Tree Number: T6.7.2.3.14
database_cross_reference: MSH:D000072500
database_cross_reference: NDFRT:N0000193113

Cytochrome P450 Family 27
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054791
PMOID: PMO:00019250
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP27 Enzymes
Synonym: CYP27 Family
Synonym: Cytochrome P450 Family 27 [Chemical/Ingredient]
Tree Number: T6.7.2.3.15
database_cross_reference: MSH:D000072501
database_cross_reference: NDFRT:N0000193112

Cytochrome P450 Family 46
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01047390
PMOID: PMO:00019253
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP46
Synonym: CYP46 Enzymes
Synonym: CYP46 Family
Synonym: CYP46, Cytochrome P-450
Synonym: Cytochrome P 450 CYP46
Synonym: Cytochrome P-450 CYP46
Synonym: Cytochrome P450 Family 46 [Chemical/Ingredient]
Tree Number: T6.7.2.3.16
database_cross_reference: MSH:D000072503
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000193077

Cytochrome P450 Family 51
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC01054790
PMOID: PMO:00019255
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CYP51 Enzymes
Synonym: CYP51 Family
Synonym: Cytochrome P450 Family 51 [Chemical/Ingredient]
Synonym: Family, CYP51
Tree Number: T6.7.2.3.17
database_cross_reference: MSH:D000072505
database_cross_reference: NDFRT:N0000193111

Aryl Hydrocarbon Hydroxylases
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC00001275
PMOID: PMO:00019257
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: Aryl Hydrocarbon Hydroxylases [Chemical/Ingredient]
Synonym: Aryl hydrocarbon hydroxylase
Synonym: Aryl-4-monooxygenase
Synonym: Hydroxylases, Aryl Hydrocarbon
Synonym: Microsomal Monooxygenases
Synonym: Microsomal P450 Flavoprotein-linked monooxygenase
Synonym: Microsomal monooxygenase
Synonym: Monooxygenases, Microsomal
Synonym: Unspecific monooxygenase
Synonym: Unspecific monooxygenase (substance)
Tree Number: T6.7.2.3.18
database_cross_reference: CHV:0000001488
database_cross_reference: CSP:2192-1949
database_cross_reference: MSH:D001189
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170041
database_cross_reference: SNMI:F-673C8
database_cross_reference: SNOMEDCT_US:9890008

Steroid Hydroxylases
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC00012228
PMOID: PMO:00019260
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: Hydroxylases, Steroid
Synonym: Monooxygenases, Steroid
Synonym: Steroid Hydroxylases [Chemical/Ingredient]
Synonym: Steroid Monooxygenases
Synonym: steroid hydroxylase
Synonym: steroid hydroxylases
Tree Number: T6.7.2.3.19
database_cross_reference: AOD:0000018466
database_cross_reference: CSP:2192-0005
database_cross_reference: CSP:2192-3407
database_cross_reference: CSP:2192-3650
database_cross_reference: MSH:D013250
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170030

Camphor 5-Monooxygenase
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC00022234
PMOID: PMO:00019262
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: CAMPHOR MONOOXYGENASE 005
Synonym: CYP101
Synonym: CYTOCHROME P 450 CAM
Synonym: Camphor 5 Monooxygenase
Synonym: Camphor 5-Monooxygenase [Chemical/Ingredient]
Synonym: Camphor 5-monooxygenase
Synonym: Camphor 5-monooxygenase (substance)
Synonym: Camphor-5-Monooxygenase
Synonym: Cytochrome P 450 101
Synonym: Cytochrome P 450 cam
Tree Number: T6.7.2.3.20
database_cross_reference: MSH:D019475
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170029
database_cross_reference: SNMI:F-673D8
database_cross_reference: SNOMEDCT_US:34410005

Trans-Cinnamate 4-Monooxygenase
type: Class
subclass of: Cytochrome P-450 Enzyme System
MCID: MC00039554
PMOID: PMO:00019263
Subclass_of: Cytochrome P-450 Enzyme System
Synonym: 4-Hydroxylase, Cinnamate
Synonym: 4-Hydroxylase, Trans-Cinnamic Acid
Synonym: 4-Monooxygenase CYP73, Trans-Cinnamate
Synonym: 4-Monooxygenase, Trans-Cinnamate
Synonym: Acid 4-Hydroxylase, Trans-Cinnamic
Synonym: CYP73, Trans-Cinnamate 4-Monooxygenase
Synonym: Cinnamate 4 Hydroxylase
Synonym: Cinnamate 4-Hydroxylase
Synonym: Cinnamic acid 4-hydroxylase
Synonym: TRANS CINNAMATE MONOOXYGENASE 04
Tree Number: T6.7.2.3.21
database_cross_reference: MSH:D050564
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168393
database_cross_reference: SNMI:F-67348
database_cross_reference: SNOMEDCT_US:62417001

Cytochrome a Group
type: Class
subclass of: Cytochromes
MCID: MC00421678
PMOID: PMO:00019264
Subclass_of: Cytochromes
Synonym: Cytochrome a Group [Chemical/Ingredient]
Synonym: Cytochromes Type a
Synonym: Cytochromes, Heme a
Synonym: Heme a Cytochromes
Tree Number: T6.7.2.4
database_cross_reference: MSH:D017936
database_cross_reference: NDFRT:N0000170021

Cytochromes a1
type: Class
subclass of: Cytochrome a Group
MCID: MC00024059
PMOID: PMO:00019265
Subclass_of: Cytochrome a Group
Synonym: CYTOCHROMES A 01
Synonym: Cytochrome a 1
Synonym: Cytochrome a(1)
Synonym: Cytochrome a-1
Synonym: Cytochrome a1
Synonym: Cytochromes a1 [Chemical/Ingredient]
Tree Number: T6.7.2.4.1
database_cross_reference: MSH:D045263
database_cross_reference: NDFRT:N0000170022

Cytochromes a
type: Class
subclass of: Cytochrome a Group
MCID: MC00024058
PMOID: PMO:00019266
Subclass_of: Cytochrome a Group
Synonym: Cytochrome a
Synonym: Cytochromes a [Chemical/Ingredient]
Synonym: cytochrome a
Tree Number: T6.7.2.4.2
database_cross_reference: CSP:2169-8705
database_cross_reference: MSH:D045264
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170023

Cytochromes a3
type: Class
subclass of: Cytochrome a Group
MCID: MC00421677
PMOID: PMO:00019267
Subclass_of: Cytochrome a Group
Synonym: CYTOCHROMES A 03
Synonym: Cytochrome a(3)
Synonym: Cytochrome a3
Synonym: Cytochrome a>3<
Synonym: Cytochromes a3 [Chemical/Ingredient]
Synonym: Ferrocytochrome a3
Synonym: cytochrome a3
Tree Number: T6.7.2.4.3
database_cross_reference: CSP:2169-8705
database_cross_reference: MSH:D045266
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170024
database_cross_reference: SNMI:F-67050
database_cross_reference: SNOMEDCT_US:43460006

Cytochrome d Group
type: Class
subclass of: Cytochromes
MCID: MC00024097
PMOID: PMO:00019268
Subclass_of: Cytochromes
Synonym: Cytochrome d
Synonym: Cytochrome d Group [Chemical/Ingredient]
Synonym: Cytochrome-d
Synonym: Cytochromes d
Tree Number: T6.7.2.5
database_cross_reference: MSH:D017937
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170050

Enzyme Precursors
type: Class
subclass of: Enzymes and Coenzymes
MCID: MC00004560
PMOID: PMO:00019269
Subclass_of: Enzymes and Coenzymes
Synonym: Enzyme Precursors [Chemical/Ingredient]
Synonym: Enzyme precursor
Synonym: Enzyme precursor (substance)
Synonym: Precursors, Enzyme
Synonym: Proenzyme
Synonym: Proenzyme (substance)
Synonym: Proenzyme, NOS
Synonym: Proenzymes
Synonym: Zymogens
Synonym: enzyme precursors
Tree Number: T6.7.3
database_cross_reference: AOD:0000018574
database_cross_reference: AOD:0000028318
database_cross_reference: AOD:0000028319
database_cross_reference: CHV:0000004524
database_cross_reference: CSP:1042-7279
database_cross_reference: MSH:D004792
database_cross_reference: NDFRT:N0000168402
database_cross_reference: RCD:Xa9we
database_cross_reference: SNMI:F-6F100
database_cross_reference: SNOMEDCT_US:102794000
database_cross_reference: SNOMEDCT_US:304379000

Chymotrypsinogen
type: Class
subclass of: Enzyme Precursors
MCID: MC00002896
PMOID: PMO:00019270
Subclass_of: Enzyme Precursors
Synonym: Chymotrypsinogen [Chemical/Ingredient]
Synonym: chymotripsinogen
Synonym: chymotrypsinogen
Tree Number: T6.7.3.1
database_cross_reference: AOD:0000018575
database_cross_reference: CSP:1042-7279
database_cross_reference: MSH:D002919
database_cross_reference: NDDF:005746
database_cross_reference: NDFRT:N0000168407

Factor IX
type: Class
subclass of: Enzyme Precursors
subclass of: PMO:00021947
MCID: MC00004930
PMOID: PMO:00019271
Subclass_of: Blood Coagulation Factors
Subclass_of: Enzyme Precursors
Synonym: Antihaemophilic factor B
Synonym: Antihemophilic factor B
Synonym: Autoprothrombin II
Synonym: BLOOD COAG FACTOR IX
Synonym: Blood Coagulation Factor IX
Synonym: Blood coagulation factor IX
Synonym: Blood-coagulation factor IX
Synonym: COAG FACTOR IX
Synonym: COAGULATION FACTOR VIIII
Synonym: Christmas Factor
Tree Number: T6.13.4.3
Tree Number: T6.7.3.2
database_cross_reference: CSP:0437-3432
database_cross_reference: LCH_NW:sh91000506
database_cross_reference: LNC:LP15961-3
database_cross_reference: LNC:LP21289-1
database_cross_reference: LNC:LP32026-4
database_cross_reference: LNC:LP32759-0
database_cross_reference: LNC:LP32814-3
database_cross_reference: MSH:D005164
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000192
database_cross_reference: NDFRT:N0000006024
database_cross_reference: RCD:X80Vx
database_cross_reference: RXNORM:4249
database_cross_reference: SNM:F-53080
database_cross_reference: SNMI:F-D7500
database_cross_reference: SNOMEDCT_US:54378000

Factor VII
type: Class
subclass of: Enzyme Precursors
subclass of: PMO:00021947
MCID: MC00004935
PMOID: PMO:00019272
Subclass_of: Blood Coagulation Factors
Subclass_of: Enzyme Precursors
Synonym: Autoprothrombin I
Synonym: BLOOD COAG FACTOR VII
Synonym: Blood Coagulation Factor VII
Synonym: Blood-coagulation factor VII
Synonym: COAG FACTOR VII
Synonym: Coagulation Factor VII
Synonym: Coagulation factor VII
Synonym: Coagulation factor VII (substance)
Synonym: EC 3.4.21.21
Synonym: F7
Tree Number: T6.13.4.5
Tree Number: T6.7.3.3
database_cross_reference: AOD:0000020350
database_cross_reference: ATC:B02BD05
database_cross_reference: CHV:0000004857
database_cross_reference: CSP:0437-2966
database_cross_reference: LNC:LP15966-2
database_cross_reference: LNC:LP19291-1
database_cross_reference: LNC:LP28560-8
database_cross_reference: MSH:D005167
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000211
database_cross_reference: NCI:C16570
database_cross_reference: NDDF:007575
database_cross_reference: NDFRT:N0000007576
database_cross_reference: RCD:X80W6
database_cross_reference: RXNORM:4254
database_cross_reference: SNM:F-53060
database_cross_reference: SNMI:F-D7380
database_cross_reference: SNOMEDCT_US:30804005

Pepsinogens
type: Class
subclass of: Enzyme Precursors
MCID: MC00009854
PMOID: PMO:00019273
Subclass_of: Enzyme Precursors
Synonym: PG - Pepsinogen
Synonym: Pepsinogen
Synonym: Pepsinogen (substance)
Synonym: Pepsinogen, NOS
Synonym: Pepsinogens [Chemical/Ingredient]
Synonym: pepsinogen
Tree Number: T6.7.3.4
database_cross_reference: CHV:0000009451
database_cross_reference: CSP:2442-9539
database_cross_reference: MSH:D010435
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168403
database_cross_reference: RCD:X80EW
database_cross_reference: SNMI:F-6F110
database_cross_reference: SNOMEDCT_US:102795004

Pepsinogen C
type: Class
subclass of: Pepsinogens
MCID: MC00009855
PMOID: PMO:00019274
Subclass_of: Pepsinogens
Synonym: Pepsinogen 2
Synonym: Pepsinogen C [Chemical/Ingredient]
Synonym: Pepsinogen II
Synonym: Pepsinogen II (substance)
Synonym: Progastricsin
Tree Number: T6.7.3.4.1
database_cross_reference: LNC:LP15784-9
database_cross_reference: LNC:MTHU013033
database_cross_reference: MSH:D020115
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168404
database_cross_reference: RCD:X80Eb
database_cross_reference: SNMI:F-6F130
database_cross_reference: SNOMEDCT_US:102797007

Pepsinogen A
type: Class
subclass of: Pepsinogens
MCID: MC00040322
PMOID: PMO:00019275
Subclass_of: Pepsinogens
Synonym: Pepsinogen
Synonym: Pepsinogen 1
Synonym: Pepsinogen A [Chemical/Ingredient]
Synonym: Pepsinogen I
Synonym: Pepsinogen I (substance)
Synonym: Uropepsinogen
Synonym: pepsinogen
Synonym: pepsinogen a
Synonym: pepsinogen i
Tree Number: T6.7.3.4.2
database_cross_reference: AOD:0000018577
database_cross_reference: CHV:0000015013
database_cross_reference: LCH:U003532
database_cross_reference: LCH_NW:sh85099680
database_cross_reference: LNC:LP15782-3
database_cross_reference: LNC:LP15783-1
database_cross_reference: LNC:MTHU013030
database_cross_reference: LNC:MTHU013031
database_cross_reference: MSH:D020116
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168405
database_cross_reference: RCD:X80EY
database_cross_reference: SNM:F-22550
database_cross_reference: SNMI:F-6F120
database_cross_reference: SNOMEDCT_US:102796003

Plasminogen
type: Class
subclass of: Enzyme Precursors
MCID: MC00010299
PMOID: PMO:00019276
Subclass_of: Enzyme Precursors
Synonym: EC 3.4.21.7
Synonym: Fibrinase Precursor
Synonym: Fibrinolysin Precursor
Synonym: PLG
Synonym: PLG - Plasminogen
Synonym: PLMN
Synonym: Plasmin Precursor
Synonym: Plasminogen (substance)
Synonym: Plasminogen [Chemical/Ingredient]
Synonym: Profibrinolysin
Tree Number: T6.7.3.5
database_cross_reference: AOD:0000018334
database_cross_reference: AOD:0000028320
database_cross_reference: CHV:0000009815
database_cross_reference: CSP:0437-6927
database_cross_reference: LCH:U003710
database_cross_reference: LCH_NW:sh87000088
database_cross_reference: LNC:LP16482-9
database_cross_reference: LNC:MTHU022203
database_cross_reference: MSH:D010958
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16994
database_cross_reference: NDDF:005212
database_cross_reference: NDFRT:N0000169397
database_cross_reference: RCD:X80WK
database_cross_reference: SNM:F-53150
database_cross_reference: SNMI:F-D7A00
database_cross_reference: SNOMEDCT_US:62252006

Angiostatins
type: Class
subclass of: Plasminogen
MCID: MC00101007
PMOID: PMO:00019277
Subclass_of: Plasminogen
Synonym: ANGIOSTATIN
Synonym: Angiostatin
Synonym: Angiostatins [Chemical/Ingredient]
Synonym: angiostatin
Tree Number: T6.7.3.5.1
database_cross_reference: CHV:0000027763
database_cross_reference: CSP:4009-0015
database_cross_reference: MSH:D043168
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170970
database_cross_reference: OMIM:173350

Complement Factor B
type: Class
subclass of: Enzyme Precursors
MCID: MC00010710
PMOID: PMO:00019278
Subclass_of: Enzyme Precursors
Synonym: C A 003 P PROACTIVATOR
Synonym: C A 003PA
Synonym: C3 Proactivator
Synonym: C3 proactivator
Synonym: C3PA
Synonym: C3PA (C3 proactivator)
Synonym: COMPLEMENT A 03 A PROACTIVATOR
Synonym: Complement 3 Proactivator
Synonym: Complement Factor B [Chemical/Ingredient]
Synonym: Complement Factor B, Alternative Pathway
Tree Number: T6.7.3.6
database_cross_reference: CHV:0000010191
database_cross_reference: DRUGBANK:DB00898
database_cross_reference: LNC:LP16386-2
database_cross_reference: LNC:MTHU005221
database_cross_reference: MSH:D011415
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169284
database_cross_reference: RCD:X80ZO
database_cross_reference: SNM:F-47320
database_cross_reference: SNMI:F-C7350
database_cross_reference: SNOMEDCT_US:123347005
database_cross_reference: SNOMEDCT_US:259787006
database_cross_reference: SNOMEDCT_US:367533005
database_cross_reference: SNOMEDCT_US:85755006

Protein C
type: Class
subclass of: Enzyme Precursors
subclass of: PMO:00020943
subclass of: PMO:00021936
subclass of: PMO:00024398
MCID: MC00498475
PMOID: PMO:00019279
Subclass_of: Blood Coagulation Factor Inhibitors
Subclass_of: Blood Proteins
Subclass_of: Enzyme Precursors
Subclass_of: Glycoproteins
Synonym: BIG-1
Synonym: Beriplex P/n 1000
Synonym: Beriplex P/n 500
Synonym: CNTN3
Synonym: PANG
Synonym: PC
Synonym: PCS
Synonym: PROC
Synonym: PROC Gene
Synonym: PROC gene
Tree Number: T6.10.3.11.7
Tree Number: T6.10.3.26.16
Tree Number: T6.13.11.2
Tree Number: T6.7.3.7
database_cross_reference: DRUGBANK:DB03403
database_cross_reference: DRUGBANK:DB11312
database_cross_reference: HGNC:HGNC:9451
database_cross_reference: MTH:NOCODE
database_cross_reference: NCBI_Gene:3872
database_cross_reference: NCBI_Gene:5067
database_cross_reference: NCBI_Gene:5624
database_cross_reference: NCI:C102824
database_cross_reference: OMIM:612283

Prothrombin
type: Class
subclass of: Enzyme Precursors
subclass of: PMO:00021947
MCID: MC00010803
PMOID: PMO:00019280
Subclass_of: Blood Coagulation Factors
Subclass_of: Enzyme Precursors
Synonym: BLOOD COAG FACTOR II
Synonym: Blood Coagulation Factor II
Synonym: Blood-coagulation factor II
Synonym: COAG FACTOR II
Synonym: Coagulation Factor II
Synonym: Coagulation factor II
Synonym: Coagulation factor II (substance)
Synonym: Differentiation Reversal Factor
Synonym: EC 3.4.21.5
Synonym: Factor II
Tree Number: T6.13.4.20
Tree Number: T6.7.3.8
database_cross_reference: AOD:0000007273
database_cross_reference: CHV:0000010259
database_cross_reference: CHV:0000048781
database_cross_reference: CSP:0437-7626
database_cross_reference: DRUGBANK:DB11300
database_cross_reference: LCH:U003883
database_cross_reference: LCH_NW:sh85107736
database_cross_reference: LNC:LP16010-8
database_cross_reference: LNC:LP21283-4
database_cross_reference: MSH:D011516
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000200
database_cross_reference: MTH:U000214
database_cross_reference: NCI:C82854
database_cross_reference: NDFRT:N0000171497
database_cross_reference: RCD:X80W4
database_cross_reference: RXNORM:1441688
database_cross_reference: SNM:F-53020
database_cross_reference: SNMI:F-D7100
database_cross_reference: SNOMEDCT_US:7348004

Trypsinogen
type: Class
subclass of: Enzyme Precursors
MCID: MC00013170
PMOID: PMO:00019281
Subclass_of: Enzyme Precursors
Synonym: Trypsinogen (substance)
Synonym: Trypsinogen [Chemical/Ingredient]
Synonym: trypsinogen
Tree Number: T6.7.3.9
database_cross_reference: AOD:0000018576
database_cross_reference: CHV:0000012616
database_cross_reference: CSP:2445-0142
database_cross_reference: LCH:U004804
database_cross_reference: LCH_NW:sh85138303
database_cross_reference: LNC:LP15929-0
database_cross_reference: LNC:MTHU007767
database_cross_reference: MSH:D014362
database_cross_reference: NDFRT:N0000168406
database_cross_reference: SNM:F-23430
database_cross_reference: SNMI:F-62F10
database_cross_reference: SNOMEDCT_US:102700004

Enzymes
type: Class
subclass of: Enzymes and Coenzymes
MCID: MC00004564
PMOID: PMO:00019282
Subclass_of: Enzymes and Coenzymes
Synonym: 66-6F ENZYMES
Synonym: Biocatalysts
Synonym: ENZYMES
Synonym: Enzyme
Synonym: Enzyme (substance)
Synonym: Enzyme, NOS
Synonym: Enzymes [Chemical/Ingredient]
Synonym: enzyme
Synonym: enzymes
Synonym: enzymes (medication)
Tree Number: T6.7.4
database_cross_reference: AOD:0000001362
database_cross_reference: CHV:0000004527
database_cross_reference: CSP:1042-3245
database_cross_reference: LCH:U001618
database_cross_reference: LCH_NW:sh85044229
database_cross_reference: LNC:LP21234-7
database_cross_reference: LNC:LP21235-4
database_cross_reference: LNC:LP31392-1
database_cross_reference: MEDCIN:40827
database_cross_reference: MSH:D004798
database_cross_reference: MTH:U001892
database_cross_reference: NCI:C16554
database_cross_reference: NCI_NCI-GLOSS:CDR0000046081
database_cross_reference: NDFRT:N0000008262
database_cross_reference: PDQ:CDR0000043129
database_cross_reference: PSY:17630
database_cross_reference: RCD:X7996
database_cross_reference: SNM:F-20000
database_cross_reference: SNM:U000193
database_cross_reference: SNMI:F-66000
database_cross_reference: SNOMEDCT_US:122969000
database_cross_reference: SNOMEDCT_US:90668006

Deubiquitinating Enzymes
type: Class
subclass of: Enzymes
MCID: MC00455646
PMOID: PMO:00019283
Subclass_of: Enzymes
Synonym: Deubiquitinases
Synonym: Deubiquitinating Enzyme
Synonym: Deubiquitinating Enzymes [Chemical/Ingredient]
Synonym: Enzymes, Deubiquitinating
Tree Number: T6.7.4.1
database_cross_reference: MSH:D000072017
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C21557
database_cross_reference: NDFRT:N0000193005

Ataxin-3
type: Class
subclass of: Deubiquitinating Enzymes
MCID: MC00998694
PMOID: PMO:00019284
Subclass_of: Deubiquitinating Enzymes
Synonym: ATAXIN003
Synonym: ATXN3 Protein
Synonym: Ataxin 3
Synonym: Ataxin 3 Protein
Synonym: Ataxin-3 Protein
Synonym: Ataxin-3 [Chemical/Ingredient]
Synonym: Machado Joseph Disease Protein
Synonym: Machado-Joseph Disease Protein
Synonym: SCA3 Protein
Synonym: Spinocerebellar Ataxia 3 Protein
Tree Number: T6.7.4.1.1
database_cross_reference: MSH:D000067699
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000191995

Deubiquitinating Enzyme CYLD
type: Class
subclass of: Deubiquitinating Enzymes
MCID: MC00815560
PMOID: PMO:00019285
Subclass_of: Deubiquitinating Enzymes
Synonym: CYLD
Synonym: CYLD protein, human
Synonym: EC 3.4.19.12
Synonym: Probable Ubiquitin Carboxyl-Terminal Hydrolase CYLD
Synonym: Ubiquitin Carboxyl-Terminal Hydrolase CYLD
Synonym: Ubiquitin Specific Peptidase Like 2
Synonym: Ubiquitin Thioesterase CYLD
Synonym: Ubiquitin Thiolesterase CYLD
Synonym: Ubiquitin-Specific-Processing Protease CYLD
Synonym: cylindromatosis protein, human
Tree Number: T6.7.4.1.2
database_cross_reference: MSH:C409984
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92683

Ubiquitin Thiolesterase
type: Class
subclass of: Deubiquitinating Enzymes
subclass of: PMO:00021873
MCID: MC00063897
PMOID: PMO:00019286
Subclass_of: Deubiquitinating Enzymes
Subclass_of: Parkinson Disease Associated Proteins
Synonym: C-Terminal Esterase, Ubiquitin
Synonym: C-Terminal Hydrolase, Ubiquitin
Synonym: Carboxy-Terminal Esterase, Ubiquitin
Synonym: Carboxy-Terminal Hydrolase, Ubiquitin
Synonym: Esterase, Ubiquitin C-Terminal
Synonym: Esterase, Ubiquitin Carboxy-Terminal
Synonym: Hydrolase, Ubiquitin C-Terminal
Synonym: Hydrolase, Ubiquitin Carboxy-Terminal
Synonym: Thiolesterase, Ubiquitin
Synonym: UCH
Tree Number: T6.10.3.2.4
Tree Number: T6.7.4.1.3
database_cross_reference: MSH:D043222
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C21558
database_cross_reference: NDFRT:N0000167610
database_cross_reference: SNOMEDCT_US:130487005

Ubiquitin-Specific Proteases
type: Class
subclass of: Deubiquitinating Enzymes
MCID: MC00220019
PMOID: PMO:00019288
Subclass_of: Deubiquitinating Enzymes
Synonym: Proteases, Ubiquitin-Specific
Synonym: Ubiquitin Specific Proteases
Synonym: Ubiquitin-Specific Proteases [Chemical/Ingredient]
Synonym: ubiquitin-specific protease
Tree Number: T6.7.4.1.4
database_cross_reference: MSH:D064570
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000189430

Tumor Necrosis Factor alpha-Induced Protein 3
type: Class
subclass of: PMO:00021684
MCID: MC00065768
PMOID: PMO:00019289
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: A20 protein, human
Synonym: EC 3.4.19.12
Synonym: EC 6.3.2.-
Synonym: OTU Domain-Containing Protein 7C
Synonym: Putative DNA-Binding Protein A20
Synonym: TNF Alpha-Induced Protein 3
Synonym: TNFAIP3
Synonym: TNFAIP3 protein, human
Synonym: Tumor Necrosis Factor Alpha-Induced Protein 3
Synonym: Zinc Finger Protein A20
Tree Number: T6.10.2.33.5
Tree Number: T6.10.3.86.4
database_cross_reference: MSH:C076529
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84996

Enzymes, Immobilized
type: Class
subclass of: Enzymes
subclass of: PMO:00023925
MCID: MC00004565
PMOID: PMO:00019290
Subclass_of: Enzymes
Subclass_of: Immobilized Proteins
Synonym: Enzyme, Immobilized
Synonym: Enzymes, Immobilized [Chemical/Ingredient]
Synonym: Immobilized Enzyme
Synonym: Immobilized Enzymes
Synonym: Immobilized enzymes
Synonym: immobilized enzyme
Tree Number: T6.10.3.93.1
Tree Number: T6.7.4.2
database_cross_reference: CSP:1042-6055
database_cross_reference: LCH_NW:sh85064525
database_cross_reference: MSH:D004800
database_cross_reference: NDFRT:N0000167526

Hydrolases
type: Class
subclass of: Enzymes
MCID: MC00006472
PMOID: PMO:00019291
Subclass_of: Enzymes
Synonym: 6A0-6B6 HYDROLASES
Synonym: EC 3
Synonym: HYDROLASES
Synonym: Hydrolase
Synonym: Hydrolase (substance)
Synonym: Hydrolase [Ambiguous]
Synonym: Hydrolase, NOS
Synonym: Hydrolases [Chemical/Ingredient]
Synonym: hydrolase
Synonym: hydrolases
Tree Number: T6.7.4.3
database_cross_reference: AOD:0000018259
database_cross_reference: CHV:0000006361
database_cross_reference: CSP:1476-6732
database_cross_reference: LCH:U002283
database_cross_reference: LCH_NW:sh85063449
database_cross_reference: MSH:D006867
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16701
database_cross_reference: NDFRT:N0000007978
database_cross_reference: RCD:Xa9te
database_cross_reference: SNM:F-21790
database_cross_reference: SNMI:F-6A000
database_cross_reference: SNOMEDCT_US:304259005
database_cross_reference: SNOMEDCT_US:74628008

Protein Deglycase DJ-1
type: Class
subclass of: Hydrolases
subclass of: PMO:00021873
MCID: MC01047414
PMOID: PMO:00019292
Subclass_of: Hydrolases
Subclass_of: Parkinson Disease Associated Proteins
Synonym: DJ 1 PARK7 Protein
Synonym: DJ 1 Protein
Synonym: DJ-1 Protein
Synonym: DJ-1, Protein Deglycase
Synonym: DJ-1-PARK7 Protein
Synonym: DJ1 Protein
Synonym: Deglycase, Parkinsonism Associated
Synonym: PARK7 Protein
Synonym: Parkinson Protein 7
Synonym: Parkinsonism Associated Deglycase
Tree Number: T6.10.3.2.2
Tree Number: T6.7.4.3.1
database_cross_reference: MSH:D000071617
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000193084

Protein-Arginine Deiminases
type: Class
subclass of: Hydrolases
PMOID: PMO:00019293
Subclass_of: Hydrolases
Tree Number: T6.7.4.3.2

Amidohydrolases
type: Class
subclass of: Hydrolases
MCID: MC00000719
PMOID: PMO:00019294
Subclass_of: Hydrolases
Synonym: Amidases
Synonym: Amidohydrolases [Chemical/Ingredient]
Synonym: amidinohydrolase
Synonym: amidohydrolase
Synonym: amidohydrolases
Tree Number: T6.7.4.3.3
database_cross_reference: AOD:0000018260
database_cross_reference: CSP:0114-2530
database_cross_reference: CSP:0116-0420
database_cross_reference: LCH_NW:sh91006084
database_cross_reference: MSH:D000581
database_cross_reference: MTH:U001678
database_cross_reference: NDFRT:N0000007690

Mi-2 Nucleosome Remodeling and Deacetylase Complex
type: Class
subclass of: Multienzyme Complexes
MCID: MC00347863
PMOID: PMO:00019306
Subclass_of: Multienzyme Complexes
Synonym: Complex, NuRD
Synonym: Histone Deacetylase Complex MI 2
Synonym: Histone Deacetylase Complex MI-2
Synonym: Histone Deacetylase Complex NuRD
Synonym: Mi 2 Nucleosome Remodeling and Deacetylase Complex
Synonym: Mi-2 Nucleosome Remodeling and Deacetylase Complex [Chemical/Ingredient]
Synonym: NuRD Complex
Synonym: NuRD Histone Deacetylase Complex
Synonym: Nucleosome Remodeling and Deacetylase Complex
Tree Number: T6.7.4.8.15
database_cross_reference: MSH:D056245
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000180225

Sin3 Histone Deacetylase and Corepressor Complex
type: Class
subclass of: Multienzyme Complexes
MCID: MC00347862
PMOID: PMO:00019309
Subclass_of: Multienzyme Complexes
Synonym: Corepressor Complex, Sin3
Synonym: SIN 3 Histone Deacetylase Complex
Synonym: SIN-3 Histone Deacetylase Complex
Synonym: SIN3 Complex
Synonym: SIN3 Histone Deacetylase Complex
Synonym: Sin3 Corepressor Complex
Synonym: Sin3 Histone Deacetylase and Corepressor Complex [Chemical/Ingredient]
Synonym: Sin3-Histone Deacetylase (HDAC) Corepressor Complex
Tree Number: T6.7.4.8.16
database_cross_reference: MSH:D056264
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000180224

Sirtuins
type: Class
subclass of: PMO:00021684
MCID: MC00377874
PMOID: PMO:00019311
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: SILENT MATING TYPE INFORMATION REGULAT 2 LIKE PROTEINS
Synonym: SIR 02 LIKE PROTEINS
Synonym: Silent Mating Type Information Regulator 2 like Proteins
Synonym: Silent Mating Type Information Regulator 2-like Proteins
Synonym: Sir2 like Proteins
Synonym: Sir2-like Proteins
Synonym: Sirtuins [Chemical/Ingredient]
Tree Number: T6.10.3.86.29
database_cross_reference: LCH_NW:sh2010012830
database_cross_reference: MSH:D037761
database_cross_reference: NDFRT:N0000168355

Sirtuin 3
type: Class
subclass of: PMO:00023874
MCID: MC00749095
PMOID: PMO:00019314
Subclass_of: Mitochondrial Proteins
Synonym: Silent Mating Type Information Regulation 2 Homolog 3
Synonym: Sirtuin 3 [Chemical/Ingredient]
Tree Number: T6.10.3.74.8
database_cross_reference: MSH:D056566
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000180280

Aminohydrolases
type: Class
subclass of: Hydrolases
MCID: MC00000761
PMOID: PMO:00019326
Subclass_of: Hydrolases
Synonym: Aminohydrolases [Chemical/Ingredient]
Synonym: aminohydrolase
Synonym: aminohydrolases
Tree Number: T6.7.4.3.4
database_cross_reference: AOD:0000018266
database_cross_reference: CSP:0137-4782
database_cross_reference: MSH:D000619
database_cross_reference: NDFRT:N0000008276

Complement Activating Enzymes
type: Class
subclass of: Hydrolases
MCID: MC00003154
PMOID: PMO:00019340
Subclass_of: Hydrolases
Synonym: Activating Enzymes, Complement
Synonym: Complement Activating Enzymes [Chemical/Ingredient]
Synonym: Enzymes, Complement Activating
Tree Number: T6.7.4.3.5
database_cross_reference: MSH:D003166
database_cross_reference: NDFRT:N0000169291

Epoxide Hydrolases
type: Class
subclass of: Hydrolases
MCID: MC00004630
PMOID: PMO:00019344
Subclass_of: Hydrolases
Synonym: Arene-oxide hydratase
Synonym: Epoxide Hydrases
Synonym: Epoxide Hydratases
Synonym: Epoxide Hydrolases [Chemical/Ingredient]
Synonym: Epoxide hydratase
Synonym: Epoxide hydrolase
Synonym: Epoxide hydrolase (substance)
Synonym: Hydrases, Epoxide
Synonym: Hydratases, Epoxide
Synonym: Hydrolases, Epoxide
Tree Number: T6.7.4.3.6
database_cross_reference: CHV:0000004582
database_cross_reference: CSP:1476-8918
database_cross_reference: MSH:D004851
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167599
database_cross_reference: SNMI:F-6AAF8
database_cross_reference: SNOMEDCT_US:3610002

Esterases
type: Class
subclass of: Hydrolases
MCID: MC00004727
PMOID: PMO:00019345
Subclass_of: Hydrolases
Synonym: EC 3.1
Synonym: EC 3.1.-.-
Synonym: Ester Hydrolase
Synonym: Esterase
Synonym: Esterase (substance)
Synonym: Esterases [Chemical/Ingredient]
Synonym: ester hydrolase
Synonym: esterase
Synonym: esterases
Tree Number: T6.7.4.3.7
database_cross_reference: AOD:0000018267
database_cross_reference: AOD:0000028227
database_cross_reference: CHV:0000004669
database_cross_reference: CSP:1064-0513
database_cross_reference: LCH_NW:sh89000683
database_cross_reference: LNC:LP17404-2
database_cross_reference: MSH:D004950
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16561
database_cross_reference: NCI:C90042
database_cross_reference: NCI:C98122
database_cross_reference: NDFRT:N0000007782
database_cross_reference: PSY:17970
database_cross_reference: RCD:Xa9ti
database_cross_reference: SNM:F-21160
database_cross_reference: SNOMEDCT_US:130196001
database_cross_reference: SNOMEDCT_US:304261001

Pancrelipase
type: Class
subclass of: PMO:00024243
MCID: MC00265563
PMOID: PMO:00019354
Subclass_of: Pancreatic Extracts
Synonym: 1,4-alpha-D- glucan glucanohydrolase
Synonym: Bio-zyme Tab 50mg
Synonym: Lipancreatin
Synonym: Neo Life Enzyme Tab
Synonym: PA
Synonym: PANCRELIPASE
Synonym: Pancrealipase
Synonym: Pancreatic alpha-amylase precursor
Synonym: Pancreatic extract pancrelipase
Synonym: Pancreatic protease
Tree Number: T6.12.11.4.2
database_cross_reference: CHV:0000048660
database_cross_reference: DRUGBANK:DB00085
database_cross_reference: DRUGBANK:DB13147
database_cross_reference: MEDCIN:198548
database_cross_reference: MMSL:41216
database_cross_reference: MMSL:d01002
database_cross_reference: MSH:D020799
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:FQ3DRG0N5K
database_cross_reference: NCI:C29345
database_cross_reference: NCI_FDA:FQ3DRG0N5K
database_cross_reference: NDDF:001235
database_cross_reference: NDFRT:N0000007141
database_cross_reference: NDFRT:N0000146447
database_cross_reference: PDQ:CDR0000043514
database_cross_reference: RXNORM:235379
database_cross_reference: SNM:E-8925
database_cross_reference: SNMI:C-85430
database_cross_reference: SNOMEDCT_US:387265002
database_cross_reference: SNOMEDCT_US:48647005
database_cross_reference: USPMG:MTHU001182
database_cross_reference: VANDF:4018109

Peroxiredoxin VI
type: Class
subclass of: PMO:00020867
MCID: MC00621639
PMOID: PMO:00019373
Subclass_of: Multifunctional Enzymes
Synonym: Peroxiredoxin 6
Synonym: Peroxiredoxin VI [Chemical/Ingredient]
Synonym: peroxiredoxin 6
Tree Number: T6.7.4.18.8
database_cross_reference: MSH:D054465
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178748

MRE11 Homologue Protein
type: Class
subclass of: PMO:00022601
PMOID: PMO:00019383
Subclass_of: DNA-Binding Proteins
Tree Number: T6.10.3.19.13

DNA Restriction Enzymes
type: Class
subclass of: PMO:00020857
MCID: MC00004120
PMOID: PMO:00019386
Subclass_of: DNA Restriction-Modification Enzymes
Synonym: DNA Restriction Enzyme
Synonym: DNA Restriction Enzymes [Chemical/Ingredient]
Synonym: Endonuclease, Restriction
Synonym: Endonucleases, Restriction
Synonym: Enzymes, DNA Restriction
Synonym: Restriction Endonuclease
Synonym: Restriction Endonucleases
Synonym: Restriction Enzyme
Synonym: Restriction Enzyme, DNA
Synonym: Restriction Enzymes, DNA
Tree Number: T6.7.4.11.1
database_cross_reference: CHV:0000004069
database_cross_reference: CSP:2101-1656
database_cross_reference: CSP:5004-0030
database_cross_reference: LCH_NW:sh85113284
database_cross_reference: MSH:D004262
database_cross_reference: NCI:C16515
database_cross_reference: NDFRT:N0000168074

Holliday Junction Resolvases
type: Class
subclass of: PMO:00020861
MCID: MC00206432
PMOID: PMO:00019398
Subclass_of: Recombinases
Synonym: Cruciform Cutting Endonuclease
Synonym: Cruciform DNA Resolving Endonuclease
Synonym: Endonuclease, Cruciform Cutting
Synonym: Holliday Junction Resolvase
Synonym: Holliday Junction Resolvases [Chemical/Ingredient]
Synonym: Resolvase, Holliday Junction
Synonym: Resolvases, Holliday Junction
Tree Number: T6.7.4.15.4
database_cross_reference: MSH:D045565
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167662

Phosphoinositide Phospholipase C
type: Class
subclass of: PMO:00021684
MCID: MC00044457
PMOID: PMO:00019417
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: 1 Phosphatidyl D myo Inositol 4,5 bisphosphate Inositoltrisphosphohydrolase
Synonym: 1 Phosphatidylinositol 4,5 Bisphosphate Phosphodiesterase
Synonym: 1-Phosphatidyl-D-myo-Inositol-4,5-bisphosphate Inositoltrisphosphohydrolase
Synonym: 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase
Synonym: 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase
Synonym: 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase (substance)
Synonym: Inositoltrisphosphohydrolase, 1-Phosphatidyl-D-myo-Inositol-4,5-bisphosphate
Synonym: PIP2 Phosphoinositidase C
Synonym: PIP2-PLC
Synonym: PIP2-Phosphoinositidase C
Tree Number: T6.10.2.33.51
Tree Number: T6.10.3.86.57
database_cross_reference: MSH:D054801
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178612
database_cross_reference: SNMI:F-6A4B0
database_cross_reference: SNMI:F-6A4B8
database_cross_reference: SNOMEDCT_US:15298004
database_cross_reference: SNOMEDCT_US:7848009

3',5'-Cyclic-AMP Phosphodiesterases
type: Class
subclass of: PMO:00021684
MCID: MC00000052
PMOID: PMO:00019425
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: 3 5 CYCL NPD
Synonym: 3',5' Cyclic AMP 5' Nucleotidohydrolase
Synonym: 3',5' Cyclic AMP Phosphodiesterase
Synonym: 3',5' Cyclic AMP Phosphodiesterases
Synonym: 3',5' Cyclic Nucleotide Phosphodiesterase
Synonym: 3',5' Nucleotide Phosphodiesterase
Synonym: 3',5'-Cyclic AMP 5'-Nucleotidohydrolase
Synonym: 3',5'-Cyclic AMP Phosphodiesterase
Synonym: 3',5'-Cyclic Nucleotide Phosphodiesterase
Synonym: 3',5'-Cyclic-AMP Phosphodiesterase
Tree Number: T6.10.2.33.13
Tree Number: T6.10.3.86.12
database_cross_reference: CSP:2100-6320
database_cross_reference: MSH:D015105
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167617
database_cross_reference: SNMI:F-6A4E8
database_cross_reference: SNOMEDCT_US:5950004

3',5'-Cyclic-GMP Phosphodiesterases
type: Class
subclass of: PMO:00021684
MCID: MC00000053
PMOID: PMO:00019433
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: 3',5' Cyclic GMP 5' Nucleotidohydrolase
Synonym: 3',5' Cyclic GMP Phosphodiesterase
Synonym: 3',5' Cyclic GMP Phosphodiesterases
Synonym: 3',5'-Cyclic GMP 5'-Nucleotidohydrolase
Synonym: 3',5'-Cyclic GMP Phosphodiesterase
Synonym: 3',5'-Cyclic-GMP 5'-nucleotidohydrolase
Synonym: 3',5'-Cyclic-GMP Phosphodiesterase
Synonym: 3',5'-Cyclic-GMP Phosphodiesterases [Chemical/Ingredient]
Synonym: 3',5'-Cyclic-GMP phosphodiesterase
Synonym: 3',5'-Cyclic-GMP phosphodiesterase (substance)
Tree Number: T6.10.2.33.14
Tree Number: T6.10.3.86.13
database_cross_reference: MSH:D015106
database_cross_reference: NDFRT:N0000167613
database_cross_reference: SNMI:F-6A4F0
database_cross_reference: SNOMEDCT_US:25978004

Calcineurin
type: Class
subclass of: PMO:00021684
MCID: MC00022158
PMOID: PMO:00019456
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Calcineurin [Chemical/Ingredient]
Synonym: PROTEIN PHOSPHATASE B 02
Synonym: Phosphatase 3, Protein
Synonym: Protein Phosphatase 2B
Synonym: Protein Phosphatase 3
Synonym: Protein Phosphatase-2B
Synonym: Protein phosphatase 3
Synonym: Protein phosphatase 3 (substance)
Synonym: calcineurin
Tree Number: T6.10.2.33.19
Tree Number: T6.10.3.86.18
database_cross_reference: CHV:0000013651
database_cross_reference: CSP:4000-0134
database_cross_reference: LNC:LP95253-8
database_cross_reference: LNC:MTHU034367
database_cross_reference: MSH:D019703
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17275
database_cross_reference: NDFRT:N0000167646
database_cross_reference: SNOMEDCT_US:712717007

Dual-Specificity Phosphatases
type: Class
subclass of: PMO:00020867
subclass of: PMO:00021684
MCID: MC00628768
PMOID: PMO:00019458
Subclass_of: Intracellular Signaling Peptides and Proteins
Subclass_of: Multifunctional Enzymes
Synonym: DUSP Phosphatases
Synonym: Dual Specificity Phosphatase
Synonym: Dual Specificity Phosphatases
Synonym: Dual-Specificity Phosphatase
Synonym: Dual-Specificity Phosphatases [Chemical/Ingredient]
Synonym: Phosphatase, Dual-Specificity
Synonym: Phosphatases, DUSP
Synonym: Phosphatases, Dual-Specificity
Tree Number: T6.10.2.33.47
Tree Number: T6.10.3.86.53
Tree Number: T6.7.4.18.9
database_cross_reference: MSH:D054637
database_cross_reference: NDFRT:N0000178789

cdc25 Phosphatases
type: Class
subclass of: PMO:00023838
MCID: MC00083081
PMOID: PMO:00019459
Subclass_of: Cell Cycle Proteins
Synonym: CDC 025 PHOSPHATASES
Synonym: Phosphatase, cdc25
Synonym: Phosphatases, cdc25
Synonym: cdc25 Phosphatase
Synonym: cdc25 Phosphatases [Chemical/Ingredient]
Tree Number: T6.10.3.64.7
database_cross_reference: MSH:D020687
database_cross_reference: NDFRT:N0000170195

Protein Phosphatase 2
type: Class
subclass of: PMO:00021684
MCID: MC00577357
PMOID: PMO:00019465
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: PP2A
Synonym: PROTEIN PHOSPHATASE 002
Synonym: Protein Phosphatase 2 [Chemical/Ingredient]
Synonym: Protein Phosphatase 2A
Synonym: Protein Phosphatase-2A
Tree Number: T6.10.2.33.49
Tree Number: T6.10.3.86.55
database_cross_reference: MSH:D054648
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C42582
database_cross_reference: NDFRT:N0000178733

Receptor-Like Protein Tyrosine Phosphatases
type: Class
subclass of: PMO:00021684
subclass of: PMO:00023060
MCID: MC00628751
PMOID: PMO:00019468
Subclass_of: Intracellular Signaling Peptides and Proteins
Subclass_of: Membrane Proteins
Synonym: Protein Tyrosine Phosphatases, Receptor Like
Synonym: Protein Tyrosine Phosphatases, Receptor-Like
Synonym: Receptor Like Protein Tyrosine Phosphatases
Synonym: Receptor-Like Protein Tyrosine Phosphatases [Chemical/Ingredient]
Tree Number: T6.10.2.33.44
Tree Number: T6.10.3.32.40
Tree Number: T6.10.3.86.50
database_cross_reference: MSH:D054557
database_cross_reference: NDFRT:N0000178780

Protein Tyrosine Phosphatases, Non-Receptor
type: Class
subclass of: PMO:00021684
MCID: MC00628752
PMOID: PMO:00019477
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Cytosolic Protein Tyrosine Phosphatase
Synonym: Non Transmembrane Protein Tyrosine Phosphatases
Synonym: Non-Receptor PTPase
Synonym: Non-Receptor Protein Tyrosine Phosphatase
Synonym: Non-Receptor Type Protein Tyrosine Phosphatase
Synonym: Non-Transmembrane Protein Tyrosine Phosphatases
Synonym: Protein Tyrosine Phosphatase Non-Receptor Type
Synonym: Protein Tyrosine Phosphatases, Non Receptor
Synonym: Protein Tyrosine Phosphatases, Non-Receptor [Chemical/Ingredient]
Synonym: Tyrosine-Protein Phosphatase Non-Receptor Type
Tree Number: T6.10.2.33.45
Tree Number: T6.10.3.86.51
database_cross_reference: MSH:D054558
database_cross_reference: NCI:C106408
database_cross_reference: NDFRT:N0000178781

SH2 Domain-Containing Protein Tyrosine Phosphatases
type: Class
subclass of: PMO:00021684
MCID: MC00621297
PMOID: PMO:00019487
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Domain-Containing Protein-Tyrosine-Phosphatases, SH2
Synonym: Protein-Tyrosine-Phosphatases, SH2 Domain-Containing
Synonym: SH Z 002 DOMAIN CONTAINING
Synonym: SH2 Domain Containing Protein Tyrosine Phosphatase
Synonym: SH2 Domain Containing Protein Tyrosine Phosphatases
Synonym: SH2 Domain-Containing Protein Tyrosine Phosphatase
Synonym: SH2 Domain-Containing Protein Tyrosine Phosphatases [Chemical/Ingredient]
Synonym: SH2 Domain-Containing Protein-Tyrosine-Phosphatases
Synonym: Src Homology-2 (SH2) Domain-Containing Phosphatase
Synonym: Src Homology-2 (SH2) Domain-Containing Phosphatases
Tree Number: T6.10.2.33.46
Tree Number: T6.10.3.86.52
database_cross_reference: MSH:D054593
database_cross_reference: NDFRT:N0000178746

Phosphofructokinase-2
type: Class
subclass of: PMO:00020867
MCID: MC00018500
PMOID: PMO:00019488
Subclass_of: Multifunctional Enzymes
Synonym: 6-Phosphofructo-2-kinase
Synonym: 6-Phosphofructo-2-kinase (substance)
Synonym: 6PF2K
Synonym: ATP-D-Fructose-6-phosphate 2-phosphotransferase
Synonym: Fru-6-P,2-kinase
Synonym: Fructose-6-P,2-kinase
Synonym: Fructose-6-phosphate,2-kinase
Synonym: PHOSPHOFRUCTOKINASE 02
Synonym: PHOSPHOFRUCTOKINASE 06 02
Synonym: Phosphofructokinase 2
Tree Number: T6.7.4.18.6
database_cross_reference: MSH:D025481
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168220
database_cross_reference: SNMI:F-692D8
database_cross_reference: SNOMEDCT_US:9623003

PTEN Phosphohydrolase
type: Class
subclass of: PMO:00021684
MCID: MC00533280
PMOID: PMO:00019489
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: MMAC1 Protein
Synonym: Mutated In Multiple Advanced Cancers 1 Protein
Synonym: PTEN Phosphatase
Synonym: PTEN Phosphohydrolase [Chemical/Ingredient]
Synonym: PTEN Protein
Synonym: PTEN Protein Phosphatase
Synonym: Phosphatase and Tensin Homologue on Chromosome Ten Protein
Synonym: Phosphatase, PTEN
Synonym: Phosphatase, PTEN Protein
Synonym: Phosphohydrolase, PTEN
Tree Number: T6.10.3.86.37
database_cross_reference: MSH:D051059
database_cross_reference: NDFRT:N0000169102

Mitogen-Activated Protein Kinase Phosphatases
type: Class
subclass of: PMO:00021684
MCID: MC00628769
PMOID: PMO:00019490
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: MAPK Phosphatases
Synonym: Mitogen Activated Protein Kinase Phosphatases
Synonym: Mitogen-Activated Protein Kinase Phosphatases [Chemical/Ingredient]
Synonym: Phosphatases, MAPK
Tree Number: T6.10.2.33.48
Tree Number: T6.10.3.86.54
database_cross_reference: MSH:D054639
database_cross_reference: NDFRT:N0000178790

Ribonuclease P
type: Class
subclass of: PMO:00020858
MCID: MC00036776
PMOID: PMO:00019494
Subclass_of: RNA, Catalytic
Synonym: RNase P
Synonym: Ribonuclease P (substance)
Synonym: Ribonuclease P [Chemical/Ingredient]
Synonym: ribonuclease P
Tree Number: T6.7.4.12.1
database_cross_reference: CSP:5000-0058
database_cross_reference: MSH:D043262
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169625
database_cross_reference: SNMI:F-6A6B0
database_cross_reference: SNOMEDCT_US:31559007

Fatty Acid Synthase, Type I
type: Class
subclass of: PMO:00020867
MCID: MC00943946
PMOID: PMO:00019510
Subclass_of: Multifunctional Enzymes
Synonym: Fatty Acid Synthase, Type I [Chemical/Ingredient]
Tree Number: T6.7.4.18.10
database_cross_reference: MSH:D054890
database_cross_reference: NDFRT:N0000178814

Glycoside Hydrolases
type: Class
subclass of: Hydrolases
MCID: MC00005771
PMOID: PMO:00019513
Subclass_of: Hydrolases
Synonym: Glycohydrolases
Synonym: Glycosidase
Synonym: Glycosidase (substance)
Synonym: Glycosidases
Synonym: Glycoside Hydrolases [Chemical/Ingredient]
Synonym: Hydrolases, Glycoside
Synonym: glycosidase
Synonym: glycoside hydrolases
Tree Number: T6.7.4.3.8
database_cross_reference: AOD:0000018313
database_cross_reference: CHV:0000005626
database_cross_reference: CSP:4000-0194
database_cross_reference: LCH_NW:sh85055406
database_cross_reference: MSH:D006026
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007895
database_cross_reference: SNOMEDCT_US:130198000

Salivary alpha-Amylases
type: Class
subclass of: PMO:00021416
MCID: MC00715399
PMOID: PMO:00019516
Subclass_of: Salivary Proteins and Peptides
Synonym: Salivary alpha Amylases
Synonym: Salivary alpha-Amylases [Chemical/Ingredient]
Synonym: alpha-Amylases, Salivary
Tree Number: T6.10.2.20.5
Tree Number: T6.10.3.50.6
database_cross_reference: MSH:D055291
database_cross_reference: NDFRT:N0000178830

Chitinase-3-Like Protein 1
type: Class
subclass of: PMO:00023892
MCID: MC00165149
PMOID: PMO:00019520
Subclass_of: Lectins
Synonym: 38-kDa heparin-binding glycoprotein, human
Synonym: 39 kDa Synovial Protein
Synonym: CGP-39
Synonym: CHI3L1 protein, human
Synonym: Cartilage Glycoprotein 39
Synonym: Chondrocyte Protein YKL40
Synonym: GP-39
Synonym: GP39 protein, human
Synonym: HC-gp39 protein, human
Synonym: HCGP39 protein, human
Tree Number: T6.10.3.84.2
database_cross_reference: LNC:LP62856-7
database_cross_reference: LNC:MTHU025707
database_cross_reference: MSH:C084533
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C93267
database_cross_reference: NCI_NCI-GLOSS:CDR0000549702

Lactase-Phlorizin Hydrolase
type: Class
subclass of: PMO:00020867
MCID: MC00043709
PMOID: PMO:00019530
Subclass_of: Multifunctional Enzymes
Synonym: Glycosyl Ceramidase
Synonym: Glycosylceramidase
Synonym: Hydrolase, Lactase-Phlorizin
Synonym: Lactase Glycosylceramidase
Synonym: Lactase Phlorizin Hydrolase
Synonym: Lactase-Glycosylceramidase
Synonym: Lactase-Phlorizin Hydrolase [Chemical/Ingredient]
Synonym: Phloretin-Glucosidase
Synonym: Phlorizin Hydrolase
Tree Number: T6.7.4.18.5
database_cross_reference: MSH:D010694
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008148

DNA Glycosylases
type: Class
subclass of: PMO:00020864
MCID: MC00049675
PMOID: PMO:00019569
Subclass_of: DNA Repair Enzymes
Synonym: DNA Glycosylase
Synonym: DNA Glycosylases [Chemical/Ingredient]
Synonym: DNA N glycosidase
Synonym: DNA N-glycosidase
Synonym: DNA glycosylase
Synonym: Glycosylase, DNA
Synonym: Glycosylases, DNA
Tree Number: T6.7.4.16.8
database_cross_reference: CSP:1334-1066
database_cross_reference: MSH:D045647
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168002

Ribosome Inactivating Proteins
type: Class
subclass of: PMO:00023657
MCID: MC00055390
PMOID: PMO:00019572
Subclass_of: Plant Proteins
Synonym: Adenosine Glycosidase, Polynucleotide
Synonym: Glycosidase, Polynucleotide Adenosine
Synonym: Glycosylase, RNA
Synonym: Inactivating Proteins, Ribosome
Synonym: N-Glycosidase, RNA
Synonym: N-Glycosylases, rRNA
Synonym: Polynucleotide Adenosine Glycosidase
Synonym: Proteins, Ribosome Inactivating
Synonym: RIP (Ribosome Inactivating Proteins)
Synonym: RNA Glycosylase
Tree Number: T6.10.3.41.14
database_cross_reference: MSH:D054788
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178619

Ricin
type: Class
subclass of: PMO:00021885
MCID: MC00384522
PMOID: PMO:00019576
Subclass_of: Albumins
Synonym: RNA N-glycosidase activity
Synonym: rRNA N-glycohydrolase activity
Synonym: rRNA N-glycosidase activity
Synonym: rRNA N-glycosylase activity
Synonym: ribosomal ribonucleate N-glycosidase activity
Synonym: ricin
Tree Number: T6.10.3.7.7
database_cross_reference: GO:GO:0030598
database_cross_reference: MTH:NOCODE

Shiga Toxins
type: Class
subclass of: PMO:00024383
subclass of: PMO:00024386
MCID: MC00057391
PMOID: PMO:00019577
Subclass_of: Bacterial Toxins
Subclass_of: Enterotoxins
Synonym: Cell Cytotoxins, Vero
Synonym: Cytotoxin, Vero
Synonym: Cytotoxin, Vero Cell
Synonym: Cytotoxins, Vero Cell
Synonym: Cytoxins, Vero
Synonym: Shiga Like Toxins
Synonym: Shiga Toxins [Chemical/Ingredient]
Synonym: Shiga-Like Toxins
Synonym: Toxin, Vero
Synonym: Toxins, Shiga
Tree Number: T6.13.8.1.10
Tree Number: T6.13.8.2.2
database_cross_reference: CHV:0000016577
database_cross_reference: CSP:5002-0060
database_cross_reference: LCH_NW:sh89005883
database_cross_reference: LNC:LP19644-1
database_cross_reference: MSH:D022603
database_cross_reference: NDFRT:N0000171390
database_cross_reference: RCD:Xa3Es
database_cross_reference: SNOMEDCT_US:285781008

Pancreatin
type: Class
subclass of: Hydrolases
subclass of: PMO:00024243
MCID: MC00009667
PMOID: PMO:00019587
Subclass_of: Hydrolases
Subclass_of: Pancreatic Extracts
Synonym: PANCREATIN
Synonym: Pancreatin (product)
Synonym: Pancreatin (substance)
Synonym: Pancreatin [Chemical/Ingredient]
Synonym: Pancreatin product
Synonym: pancreatic preparations pancreatin
Synonym: pancreatin
Synonym: pancreatin (medication)
Tree Number: T6.12.11.4.1
Tree Number: T6.7.4.3.9
database_cross_reference: CHV:0000009228
database_cross_reference: DRUGBANK:DB00085
database_cross_reference: LCH:U003456
database_cross_reference: LCH_NW:sh85097386
database_cross_reference: MEDCIN:198547
database_cross_reference: MMSL:5227
database_cross_reference: MMSL:5615
database_cross_reference: MMSL:d01003
database_cross_reference: MSH:D010194
database_cross_reference: NDDF:001234
database_cross_reference: NDFRT:N0000006694
database_cross_reference: NDFRT:N0000146740
database_cross_reference: RCD:ap1..
database_cross_reference: RXNORM:7880
database_cross_reference: SNM:E-8925
database_cross_reference: SNMI:C-85420
database_cross_reference: SNOMEDCT_US:12236006
database_cross_reference: SNOMEDCT_US:387049005
database_cross_reference: VANDF:4018414

Peptide Hydrolases
type: Class
subclass of: Hydrolases
MCID: MC00009866
PMOID: PMO:00019588
Subclass_of: Hydrolases
Synonym: Esteroproteases
Synonym: PROTEOLYTIC ENZYME
Synonym: Peptidase
Synonym: Peptidases
Synonym: Peptide Hydrolases [Chemical/Ingredient]
Synonym: Peptide hydrolase
Synonym: Peptide hydrolase (substance)
Synonym: Proteases
Synonym: Proteinases
Synonym: Proteolytic Enzymes
Tree Number: T6.7.4.3.10
database_cross_reference: AOD:0000018329
database_cross_reference: AOD:0000028246
database_cross_reference: CHV:0000009455
database_cross_reference: CSP:2436-3984
database_cross_reference: CSP:2440-7063
database_cross_reference: LCH_NW:sh85107685
database_cross_reference: MEDCIN:40842
database_cross_reference: MMSL:5379
database_cross_reference: MSH:D010447
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:001238
database_cross_reference: NDDF:014865
database_cross_reference: NDFRT:N0000005793
database_cross_reference: NDFRT:N0000146947
database_cross_reference: PDQ:CDR0000043492
database_cross_reference: RCD:Xa9ts
database_cross_reference: RCD:Xa9tx
database_cross_reference: RXNORM:8028
database_cross_reference: SNM:F-22560
database_cross_reference: SNM:F-22980
database_cross_reference: SNOMEDCT_US:124562002
database_cross_reference: SNOMEDCT_US:130202003
database_cross_reference: SNOMEDCT_US:130206000
database_cross_reference: VANDF:4018634

Coagulase
type: Class
subclass of: PMO:00021903
MCID: MC00003003
PMOID: PMO:00019604
Subclass_of: Bacterial Proteins
Synonym: Coagulase [Chemical/Ingredient]
Synonym: coagulase
Tree Number: T6.10.3.10.7
database_cross_reference: CHV:0000003088
database_cross_reference: LCH:U001064
database_cross_reference: LCH_NW:sh85027303
database_cross_reference: MSH:D003030
database_cross_reference: NDFRT:N0000169048

Separase
type: Class
subclass of: PMO:00023838
MCID: MC00265246
PMOID: PMO:00019625
Subclass_of: Cell Cycle Proteins
Synonym: Separase [Chemical/Ingredient]
Synonym: separase
Tree Number: T6.10.3.64.16
database_cross_reference: MSH:D064247
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000189432

Botulinum Toxins
type: Class
subclass of: PMO:00021903
subclass of: PMO:00024383
MCID: MC00001900
PMOID: PMO:00019628
Subclass_of: Bacterial Proteins
Subclass_of: Bacterial Toxins
Synonym: BTX - Botulinum toxin
Synonym: Botulin
Synonym: Botulin toxin
Synonym: Botulinum Toxin
Synonym: Botulinum Toxins [Chemical/Ingredient]
Synonym: Botulinum toxin
Synonym: Botulinum toxin (product)
Synonym: Botulinum toxin (substance)
Synonym: Botulism toxin
Synonym: Clostridium botulinum Toxins
Tree Number: T6.10.3.10.6
Tree Number: T6.13.8.1.1
database_cross_reference: ATC:M03AX01
database_cross_reference: CHV:0000002113
database_cross_reference: CSP:1556-7393
database_cross_reference: LCH:U000657
database_cross_reference: LCH_NW:sh85016075
database_cross_reference: LNC:LP18030-4
database_cross_reference: LNC:MTHU002713
database_cross_reference: MEDCIN:48731
database_cross_reference: MEDLINEPLUS:1557
database_cross_reference: MEDLINEPLUS:3015
database_cross_reference: MSH:D001905
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000004422
database_cross_reference: RCD:X79DH
database_cross_reference: SNM:E-1011
database_cross_reference: SNMI:C-36304
database_cross_reference: SNOMEDCT_US:11894001
database_cross_reference: SNOMEDCT_US:129470006
database_cross_reference: SNOMEDCT_US:372915002
database_cross_reference: SNOMEDCT_US:418236003
database_cross_reference: SNOMEDCT_US:419254007

Pregnancy-Associated Plasma Protein-A
type: Class
subclass of: PMO:00023681
MCID: MC00010587
PMOID: PMO:00019632
Subclass_of: Pregnancy Proteins
Synonym: IGFBP 4 Metalloproteinase
Synonym: IGFBP 4 Protease
Synonym: IGFBP-4 Metalloproteinase
Synonym: IGFBP-4 Protease
Synonym: IGFBP-4-Specific Proteinase
Synonym: Insulin Like Growth Factor Binding Protein 4 Protease
Synonym: Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease
Synonym: Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease
Synonym: Insulin-Like-Growth Factor Binding Protein-4 Protease
Synonym: Metalloproteinase, IGFBP-4
Tree Number: T6.10.3.42.6
database_cross_reference: CHV:0000010072
database_cross_reference: LNC:LP28774-5
database_cross_reference: LNC:MTHU014866
database_cross_reference: MSH:D011266
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169418
database_cross_reference: RCD:X80QA
database_cross_reference: SNOMEDCT_US:259636000

Neprilysin
type: Class
subclass of: PMO:00024309
subclass of: PMO:00024394
MCID: MC00008020
PMOID: PMO:00019636
Subclass_of: Antigens, Neoplasm
Subclass_of: Biomarkers, Tumor
Synonym: ANTIGENS CD 010
Synonym: Antigen, CD10
Synonym: Antigens, CD10
Synonym: Antigens, Leukemia, Common Acute Lymphoblastic
Synonym: Atriopeptidase
Synonym: C10
Synonym: CALLA - Common acute lymphoblastic leukaemia antigen
Synonym: CALLA - Common acute lymphoblastic leukemia antigen
Synonym: CALLA Antigen
Synonym: CALLA-Comm ac lymphobl leuk ag
Tree Number: T6.13.3.7.7
Tree Number: T6.13.9.5.6
database_cross_reference: CHV:0000007912
database_cross_reference: CHV:0000051583
database_cross_reference: CSP:4006-0102
database_cross_reference: CSP:4009-0052
database_cross_reference: LCH_NW:sh85044027
database_cross_reference: LNC:LP20022-7
database_cross_reference: LNC:LP37552-4
database_cross_reference: LNC:MTHU018351
database_cross_reference: LNC:MTHU022233
database_cross_reference: MSH:D015260
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171364
database_cross_reference: RCD:X80fB
database_cross_reference: RCDAE:X80fB
database_cross_reference: SNM:F-23700
database_cross_reference: SNMI:F-6B050
database_cross_reference: SNMI:F-C1800
database_cross_reference: SNOMEDCT_US:29681000
database_cross_reference: SNOMEDCT_US:50988004

Matrix Metalloproteinases, Membrane-Associated
type: Class
subclass of: PMO:00023060
MCID: MC00086350
PMOID: PMO:00019646
Subclass_of: Membrane Proteins
Synonym: MT MMP Enzymes
Synonym: MT-MMP Enzymes
Synonym: Matrix Metalloproteinase, Membrane Type
Synonym: Matrix Metalloproteinase, Membrane-Type
Synonym: Matrix Metalloproteinases, Membrane Associated
Synonym: Matrix Metalloproteinases, Membrane-Associated [Chemical/Ingredient]
Synonym: Matrix Metalloproteinases, Membrane-Type
Synonym: Membrane Type Matrix Metalloproteinase
Synonym: Membrane Type Matrix Metalloproteinases
Synonym: Membrane-Associated Matrix Metalloproteinases
Tree Number: T6.10.3.32.37
database_cross_reference: MSH:D053504
database_cross_reference: NDFRT:N0000175155

Matrix Metalloproteinases, Secreted
type: Class
subclass of: PMO:00021462
MCID: MC00583186
PMOID: PMO:00019651
Subclass_of: Intercellular Signaling Peptides and Proteins
Synonym: Matrix Metalloproteinases, Secreted [Chemical/Ingredient]
Synonym: Metalloproteinases, Secreted Matrix
Synonym: Secreted Matrix Metalloproteinases
Tree Number: T6.10.2.31.16
Tree Number: T6.10.3.83.15
database_cross_reference: MSH:D053505
database_cross_reference: NDFRT:N0000175149

Bone Morphogenetic Protein 1
type: Class
subclass of: Tolloid-Like Metalloproteinases
MCID: MC00133548
PMOID: PMO:00019658
Subclass_of: Tolloid-Like Metalloproteinases
Synonym: Bone Morphogenetic Protein 1 [Chemical/Ingredient]
Synonym: Procollagen C Endopeptidase
Synonym: Procollagen C-Endopeptidase
Synonym: Procollagen C-endopeptidase
Synonym: Procollagen C-endopeptidase (substance)
Tree Number: T6.13.12.21.1
database_cross_reference: MSH:D055395
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178645
database_cross_reference: SNOMEDCT_US:130697006

High-Temperature Requirement A Serine Peptidase 2
type: Class
subclass of: PMO:00021873
subclass of: PMO:00023874
PMOID: PMO:00019663
Subclass_of: Mitochondrial Proteins
Subclass_of: Parkinson Disease Associated Proteins
Tree Number: T6.10.3.2.3
Tree Number: T6.10.3.74.3

Kallikreins
type: Class
subclass of: PMO:00021947
MCID: MC00007167
PMOID: PMO:00019668
Subclass_of: Blood Coagulation Factors
Synonym: Callicrein
Synonym: Enzyme, Kinin-Forming
Synonym: KLK
Synonym: Kallidinogenase
Synonym: Kalliginogenase
Synonym: Kallikrein
Synonym: Kallikrein (substance)
Synonym: Kallikreins [Chemical/Ingredient]
Synonym: Kinin Forming Enzyme
Synonym: Kinin-Forming Enzyme
Tree Number: T6.13.4.14
database_cross_reference: ATC:C04AF01
database_cross_reference: CHV:0000007035
database_cross_reference: CSP:2237-7940
database_cross_reference: LCH:U002559
database_cross_reference: LCH_NW:sh85071358
database_cross_reference: LNC:LP16476-1
database_cross_reference: LNC:MTHU021435
database_cross_reference: MSH:D007610
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16767
database_cross_reference: NDDF:007132
database_cross_reference: NDFRT:N0000171485
database_cross_reference: RCD:X80EC
database_cross_reference: RXNORM:6095
database_cross_reference: SNM:F-46710
database_cross_reference: SNMI:F-D7D10
database_cross_reference: SNOMEDCT_US:66587009

Prekallikrein
type: Class
subclass of: Kallikreins
MCID: MC00010598
PMOID: PMO:00019669
Subclass_of: Kallikreins
Synonym: Factor, Fletcher
Synonym: Fletcher Factor
Synonym: Fletcher factor
Synonym: Kallikreinogen
Synonym: Plasma Prokallikrein
Synonym: Prekallikrein (substance)
Synonym: Prekallikrein [Chemical/Ingredient]
Synonym: Prokallikrein, Plasma
Synonym: fletcher factor
Synonym: prekallikrein
Tree Number: T6.13.4.14.1
database_cross_reference: CHV:0000010080
database_cross_reference: LNC:LP16483-7
database_cross_reference: LNC:MTHU004277
database_cross_reference: MSH:D011288
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171486
database_cross_reference: RCD:X80W1
database_cross_reference: SNMI:F-D7D00
database_cross_reference: SNOMEDCT_US:7179006

Prostate-Specific Antigen
type: Class
subclass of: PMO:00024309
subclass of: PMO:00024394
MCID: MC00054953
PMOID: PMO:00019670
Subclass_of: Antigens, Neoplasm
Subclass_of: Biomarkers, Tumor
Synonym: Antigen, Prostate-Specific
Synonym: EC 3.4.21.77
Synonym: Gamma-Seminoprotein
Synonym: HK 003 KALLIKREIN
Synonym: KALLIKREIN HK 003
Synonym: KLK3
Synonym: Kallikrein hK3
Synonym: Kallikrein, hK3
Synonym: Kallikrein-3
Synonym: P-30 Antigen
Tree Number: T6.13.3.7.9
Tree Number: T6.13.9.5.9
database_cross_reference: CCPSS:0023090
database_cross_reference: CHV:0000016464
database_cross_reference: CHV:0000054991
database_cross_reference: CSP:4005-0048
database_cross_reference: LCH_NW:sh2001002935
database_cross_reference: LNC:LP18193-0
database_cross_reference: LNC:MTHU001466
database_cross_reference: MSH:D017430
database_cross_reference: MTH:U002400
database_cross_reference: NCI:C17525
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044867
database_cross_reference: NCI_NCI-GLOSS:CDR0000046540
database_cross_reference: NDFRT:N0000171378
database_cross_reference: RCD:X80QD
database_cross_reference: SNMI:F-625C0
database_cross_reference: SNOMEDCT_US:102687007
database_cross_reference: SNOMEDCT_US:130634002
database_cross_reference: SNOMEDCT_US:143526001
database_cross_reference: SNOMEDCT_US:166158002

Tissue Kallikreins
type: Class
subclass of: PMO:00024394
MCID: MC00039428
PMOID: PMO:00019671
Subclass_of: Biomarkers, Tumor
Synonym: Glandular Kallikrein
Synonym: Glandular Kallikreins, Human
Synonym: Glandular kallikrein
Synonym: Human Glandular Kallikrein
Synonym: Human Glandular Kallikreins
Synonym: Kallikrein, Glandular
Synonym: Kallikrein, Tissue
Synonym: Kallikreins, Human Glandular
Synonym: Kallikreins, Tissue
Synonym: Tissue Kallikrein
Tree Number: T6.13.9.5.16
database_cross_reference: MSH:D020840
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C20343
database_cross_reference: NDFRT:N0000171379
database_cross_reference: SNMI:F-D7D20
database_cross_reference: SNOMEDCT_US:123344003
database_cross_reference: SNOMEDCT_US:26591003

Lactoferrin
type: Class
subclass of: PMO:00020943
MCID: MC00007335
PMOID: PMO:00019673
Subclass_of: Glycoproteins
Synonym: Lactoferrin (substance)
Synonym: Lactoferrin [Chemical/Ingredient]
Synonym: Lactoferrins
Synonym: Lactotransferrin
Synonym: lactoferrin
Tree Number: T6.10.3.26.13
database_cross_reference: CHV:0000007187
database_cross_reference: CSP:1852-3912
database_cross_reference: LCH:U002608
database_cross_reference: LCH_NW:sh85073869
database_cross_reference: LNC:LP15694-0
database_cross_reference: LNC:MTHU012322
database_cross_reference: MSH:D007781
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:011515
database_cross_reference: NDFRT:N0000169638
database_cross_reference: RCD:X80Pn
database_cross_reference: RXNORM:1425933
database_cross_reference: SNMI:F-62396
database_cross_reference: SNOMEDCT_US:102670005

Tissue Plasminogen Activator
type: Class
subclass of: PMO:00021947
MCID: MC00010300
PMOID: PMO:00019676
Subclass_of: Blood Coagulation Factors
Synonym: ALTEPLASE
Synonym: ALTEPLASE,RECOMBINANT
Synonym: Activase
Synonym: Activase RT-PA
Synonym: Activase RT-PA Inj
Synonym: Alteplase
Synonym: Alteplase (genetical recombination)
Synonym: Alteplase (product)
Synonym: Alteplase (substance)
Synonym: Alteplase - chemical
Tree Number: T6.13.4.16
database_cross_reference: ATC:B01AD02
database_cross_reference: ATC:S01XA13
database_cross_reference: CHV:0000009816
database_cross_reference: CSP:0437-7160
database_cross_reference: DRUGBANK:DB00009
database_cross_reference: LCH_NW:sh87000090
database_cross_reference: LNC:LP16891-1
database_cross_reference: LNC:MTHU019721
database_cross_reference: MEDCIN:41869
database_cross_reference: MMSL:4155
database_cross_reference: MMSL:d00521
database_cross_reference: MSH:D010959
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:1RXS4UE564
database_cross_reference: NCI:C16995
database_cross_reference: NCI:C39607
database_cross_reference: NCI_FDA:1RXS4UE564
database_cross_reference: NCI_NCI-GLOSS:CDR0000373954
database_cross_reference: NCI_NCI-GLOSS:CDR0000377718
database_cross_reference: NCI_NCI-GLOSS:CDR0000377721
database_cross_reference: NCI_NCI-GLOSS:CDR0000377722
database_cross_reference: NCI_NCI-GLOSS:CDR0000377724
database_cross_reference: NCI_NCI-GLOSS:CDR0000377725
database_cross_reference: NDDF:002074
database_cross_reference: NDFRT:N0000007047
database_cross_reference: NDFRT:N0000147508
database_cross_reference: NDFRT:N0000147695
database_cross_reference: PDQ:CDR0000042033
database_cross_reference: RCD:bv3..
database_cross_reference: RXNORM:8410
database_cross_reference: SNMI:C-A7410
database_cross_reference: SNMI:F-D7A20
database_cross_reference: SNOMEDCT_US:108997009
database_cross_reference: SNOMEDCT_US:130625007
database_cross_reference: SNOMEDCT_US:27638005
database_cross_reference: SNOMEDCT_US:37411004
database_cross_reference: SNOMEDCT_US:386956006
database_cross_reference: SNOMEDCT_US:387152000
database_cross_reference: SNOMEDCT_US:391744002
database_cross_reference: VANDF:4019319
database_cross_reference: VANDF:4019599

Thrombin
type: Class
subclass of: PMO:00021947
MCID: MC00012782
PMOID: PMO:00019681
Subclass_of: Blood Coagulation Factors
Synonym: Fibrinogenase
Synonym: THROMBIN
Synonym: Thrombase
Synonym: Thrombin (product)
Synonym: Thrombin (substance)
Synonym: Thrombin [Chemical/Ingredient]
Synonym: Thrombin agent
Synonym: Thrombin agent (substance)
Synonym: Thrombin preparation
Synonym: Thrombin preparation (substance)
Tree Number: T6.13.4.21
database_cross_reference: AOD:0000007267
database_cross_reference: ATC:B02BC06
database_cross_reference: ATC:B02BD30
database_cross_reference: CHV:0000012218
database_cross_reference: CSP:0437-8092
database_cross_reference: DRUGBANK:DB11300
database_cross_reference: LCH:U004666
database_cross_reference: LCH_NW:sh85135066
database_cross_reference: LNC:LP21102-6
database_cross_reference: MEDCIN:40940
database_cross_reference: MMSL:5578
database_cross_reference: MMSL:7976
database_cross_reference: MSH:D013917
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:25ADE2236L
database_cross_reference: NDDF:002069
database_cross_reference: NDFRT:N0000006278
database_cross_reference: NDFRT:N0000146856
database_cross_reference: RCD:X80WM
database_cross_reference: RXNORM:10528
database_cross_reference: SNM:E-8464
database_cross_reference: SNMI:C-A7040
database_cross_reference: SNMI:F-6ACA0
database_cross_reference: SNOMEDCT_US:36176003
database_cross_reference: SNOMEDCT_US:415715002
database_cross_reference: SNOMEDCT_US:48421007
database_cross_reference: VANDF:4018534

Factor VIIa
type: Class
subclass of: Factor VII
MCID: MC00004937
PMOID: PMO:00019684
Subclass_of: Factor VII
Synonym: Activated Factor VII
Synonym: Activated factor VII
Synonym: Activated factor VII products
Synonym: BLOOD COAG FACTOR VII ACTIVATED
Synonym: Blood Coagulation Factor VII, Activated
Synonym: COAG FACTOR VIIA
Synonym: Coagulation Factor VIIa
Synonym: Coagulation factor VIIa
Synonym: Coagulation factor VIIa (substance)
Synonym: Factor VII, Activated
Tree Number: T6.13.4.5.1
database_cross_reference: CHV:0000004859
database_cross_reference: DRUGBANK:DB00036
database_cross_reference: MMSL:15786
database_cross_reference: MMSL:d04719
database_cross_reference: MSH:D015942
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000006521
database_cross_reference: RCD:bw9..
database_cross_reference: RXNORM:4256
database_cross_reference: SNMI:F-D7390
database_cross_reference: SNOMEDCT_US:319918003
database_cross_reference: SNOMEDCT_US:346310008
database_cross_reference: SNOMEDCT_US:73801006

Factor XIa
type: Class
subclass of: PMO:00021953
MCID: MC00004945
PMOID: PMO:00019685
Subclass_of: Factor XI
Synonym: Activated Factor XI
Synonym: Activated factor XI
Synonym: BLOOD COAG FACTOR XI ACTIVATED
Synonym: Blood Coagulation Factor XI, Activated
Synonym: COAG FACTOR XIA
Synonym: Coagulation Factor XIa
Synonym: Coagulation Factor XIa (substance)
Synonym: Coagulation Factor XIa -RETIRED-
Synonym: Coagulation factor XIa
Synonym: Coagulation factor XIa (substance)
Tree Number: T6.13.4.8.1
database_cross_reference: MSH:D015945
database_cross_reference: NDFRT:N0000171492
database_cross_reference: SNMI:F-D7810
database_cross_reference: SNOMEDCT_US:123342004
database_cross_reference: SNOMEDCT_US:26518005

Factor IXa
type: Class
subclass of: Factor IX
MCID: MC00004931
PMOID: PMO:00019686
Subclass_of: Factor IX
Synonym: Activated Christmas Factor
Synonym: Activated Factor IX
Synonym: Activated factor IX
Synonym: BLOOD COAG FACTOR IX ACTIVATED
Synonym: Blood Coagulation Factor IX, Activated
Synonym: COAG FACTOR IXA
Synonym: COAGULATION FACTOR VIIIIA
Synonym: Coagulation Factor IXa
Synonym: Coagulation factor IXa
Synonym: Coagulation factor IXa (substance)
Tree Number: T6.13.4.3.1
database_cross_reference: MSH:D015949
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171470
database_cross_reference: SNMI:F-D7510
database_cross_reference: SNOMEDCT_US:123070009
database_cross_reference: SNOMEDCT_US:63856005

Factor Xa
type: Class
subclass of: PMO:00021952
MCID: MC00004942
PMOID: PMO:00019687
Subclass_of: Factor X
Synonym: Activated Factor X
Synonym: Activated factor X
Synonym: Autoprothrombin C
Synonym: BLOOD COAG FACTOR X ACTIVATED
Synonym: Blood Coagulation Factor X, Activated
Synonym: COAG FACTOR XA
Synonym: Coagulation Factor Xa
Synonym: Coagulation Factor Xa (substance)
Synonym: Coagulation Factor Xa -RETIRED-
Synonym: Coagulation factor Xa
Tree Number: T6.13.4.7.1
database_cross_reference: CHV:0000004864
database_cross_reference: CSP:0437-3665
database_cross_reference: MSH:D015951
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171476
database_cross_reference: SNMI:F-D7710
database_cross_reference: SNOMEDCT_US:123340007
database_cross_reference: SNOMEDCT_US:5172001
database_cross_reference: SNOMEDCT_US:81444003

Factor XIIa
type: Class
subclass of: PMO:00021954
MCID: MC00004948
PMOID: PMO:00019688
Subclass_of: Factor XII
Synonym: Activated Factor XII
Synonym: Activated factor XII
Synonym: Activator, Prekallikrein
Synonym: BLOOD COAG FACTOR XII ACTIVATED
Synonym: Blood Coagulation Factor XII, Activated
Synonym: COAG FACTOR XIIA
Synonym: Coagulation Factor XIIa
Synonym: Coagulation Factor XIIa (substance)
Synonym: Coagulation Factor XIIa -RETIRED-
Synonym: Coagulation factor XIIa
Tree Number: T6.13.4.9.1
database_cross_reference: CHV:0000004869
database_cross_reference: MSH:D015956
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171490
database_cross_reference: SNMI:F-D7860
database_cross_reference: SNOMEDCT_US:123072001
database_cross_reference: SNOMEDCT_US:75840004

Endopeptidase Clp
type: Class
subclass of: PMO:00023874
MCID: MC00020692
PMOID: PMO:00019712
Subclass_of: Mitochondrial Proteins
Synonym: ATP Dependent Endoprotease Ti
Synonym: ATP-Dependent Endoprotease Ti
Synonym: Clp Protease
Synonym: Endopeptidase Clp (substance)
Synonym: Endopeptidase Clp [Chemical/Ingredient]
Synonym: Endopeptidase Ti
Synonym: Endoprotease Ti, ATP-Dependent
Synonym: Protease Ti
Synonym: Ti Protease
Synonym: endopeptidase Clp
Tree Number: T6.10.3.74.6
database_cross_reference: MSH:D049071
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167598
database_cross_reference: SNOMEDCT_US:130649005

Tolloid-Like Metalloproteinases
type: Class
subclass of: PMO:00021462
MCID: MC00715422
PMOID: PMO:00019738
Subclass_of: Intercellular Signaling Peptides and Proteins
Synonym: Enzymes, Tolloid-Like
Synonym: Metalloproteases, Tolloid
Synonym: Metalloproteinase, Tolloid
Synonym: Metalloproteinases, Tolloid-Like
Synonym: Tolloid Like Enzymes
Synonym: Tolloid Like Metalloproteinases
Synonym: Tolloid Metalloproteases
Synonym: Tolloid Metalloproteinase
Synonym: Tolloid-Like Enzymes
Synonym: Tolloid-Like Metalloproteinases [Chemical/Ingredient]
Tree Number: T6.10.2.31.21
Tree Number: T6.10.3.83.20
Tree Number: T6.13.12.21
database_cross_reference: MSH:D055394
database_cross_reference: NDFRT:N0000178837

ADAM Proteins
type: Class
subclass of: PMO:00020943
MCID: MC00542289
PMOID: PMO:00019739
Subclass_of: Glycoproteins
Synonym: A Disintegrin and Metalloprotease Proteins
Synonym: ADAM (A Disintegrin and Metalloprotease) Proteins
Synonym: ADAM Proteins [Chemical/Ingredient]
Tree Number: T6.10.3.26.31
Tree Number: T6.8.5.3.3
database_cross_reference: MSH:D051722
database_cross_reference: NDFRT:N0000169199

Ureohydrolases
type: Class
subclass of: Hydrolases
MCID: MC00013342
PMOID: PMO:00019755
Subclass_of: Hydrolases
Synonym: Ureohydrolases [Chemical/Ingredient]
Tree Number: T6.7.4.3.11
database_cross_reference: MSH:D014512
database_cross_reference: NDFRT:N0000167686

Acid Anhydride Hydrolases
type: Class
subclass of: Hydrolases
MCID: MC00067345
PMOID: PMO:00019757
Subclass_of: Hydrolases
Synonym: Acid Anhydride Hydrolases [Chemical/Ingredient]
Synonym: Anhydride Hydrolases, Acid
Synonym: Hydrolases, Acid Anhydride
Synonym: acid anhydride hydrolase
Tree Number: T6.7.4.3.12
database_cross_reference: CSP:4000-0103
database_cross_reference: MSH:D017766
database_cross_reference: NDFRT:N0000167527

AAA Proteins
type: Class
subclass of: PMO:00022152
PMOID: PMO:00019758
Subclass_of: Carrier Proteins
Tree Number: T6.10.3.12.3

Valosin Containing Protein
type: Class
subclass of: PMO:00023838
MCID: MC00500441
PMOID: PMO:00019762
Subclass_of: Cell Cycle Proteins
Synonym: CDC48
Synonym: CDC48, YEAST, HOMOLOG OF
Synonym: IBMPFD
Synonym: P97
Synonym: VALOSIN-CONTAINING PROTEIN
Synonym: VCP
Synonym: VCP gene
Synonym: p97
Synonym: valosin containing protein
Tree Number: T6.10.3.64.3
database_cross_reference: HGNC:HGNC:12666
database_cross_reference: MTH:NOCODE
database_cross_reference: NCBI_Gene:10428
database_cross_reference: NCBI_Gene:50628
database_cross_reference: NCBI_Gene:5708
database_cross_reference: NCBI_Gene:7415
database_cross_reference: OMIM:601023

Replication Protein C
type: Class
subclass of: PMO:00022601
MCID: MC00064828
PMOID: PMO:00019764
Subclass_of: DNA-Binding Proteins
Synonym: Activator 1 Protein
Synonym: Replication Factor C
Synonym: Replication Protein C [Chemical/Ingredient]
Tree Number: T6.10.3.19.68
database_cross_reference: MSH:D051818
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169245

MutL Proteins
type: Class
subclass of: PMO:00020864
subclass of: PMO:00022601
MCID: MC01054893
PMOID: PMO:00019767
Subclass_of: DNA Repair Enzymes
Subclass_of: DNA-Binding Proteins
Synonym: MutL Proteins [Chemical/Ingredient]
Tree Number: T6.10.3.19.1
Tree Number: T6.7.4.16.1
database_cross_reference: MSH:D000070956
database_cross_reference: NDFRT:N0000193175

MutS Proteins
type: Class
subclass of: PMO:00020864
subclass of: PMO:00022601
PMOID: PMO:00019776
Subclass_of: DNA Repair Enzymes
Subclass_of: DNA-Binding Proteins
Tree Number: T6.10.3.19.10
Tree Number: T6.7.4.16.3

MutS DNA Mismatch-Binding Protein
type: Class
subclass of: PMO:00021903
MCID: MC00052977
PMOID: PMO:00019778
Subclass_of: Bacterial Proteins
Synonym: DNA Mismatch Repair Protein MutS
Synonym: MutS DNA Mismatch Binding Protein
Synonym: MutS DNA Mismatch-Binding Protein [Chemical/Ingredient]
Tree Number: T6.10.3.10.26
database_cross_reference: MSH:D051719
database_cross_reference: NDFRT:N0000169228

DNA Helicases
type: Class
subclass of: Isomerases
MCID: MC00323191
PMOID: PMO:00019779
Subclass_of: Isomerases
Synonym: DNA Helicase
Synonym: DNA Helicases [Chemical/Ingredient]
Synonym: DNA Unwinding Proteins
Synonym: DNA helicases
Synonym: DNA unwinding enzyme
Synonym: EC 3.6.4.12
Synonym: Helicase
Synonym: Helicases
Synonym: Helicases, DNA
Synonym: Unwinding Proteins, DNA
Tree Number: T6.7.4.5.1
database_cross_reference: CHV:0000052543
database_cross_reference: CSP:4001-0062
database_cross_reference: LCH_NW:sh00000062
database_cross_reference: MSH:D004265
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16517
database_cross_reference: NCI:C20423
database_cross_reference: NDFRT:N0000168096

Ku Autoantigen
type: Class
subclass of: PMO:00022601
subclass of: PMO:00023642
MCID: MC00051895
PMOID: PMO:00019780
Subclass_of: Antigens, Nuclear
Subclass_of: DNA-Binding Proteins
Synonym: Antigen, G22P1
Synonym: Antigen, Ku
Synonym: Autoantigen, Ku
Synonym: Blood group antigen K5
Synonym: Blood group antigen Ku
Synonym: Blood group antigen Ku (substance)
Synonym: G22P1 Antigen
Synonym: Heterodimer, Ku
Synonym: Ku
Synonym: Ku Antigen
Tree Number: T6.10.3.19.6
Tree Number: T6.13.3.18.1
database_cross_reference: LNC:LP19333-1
database_cross_reference: MSH:D000072200
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000192955
database_cross_reference: RCD:X80XF
database_cross_reference: SNMI:F-D2970
database_cross_reference: SNOMEDCT_US:20228006

Minichromosome Maintenance Proteins
type: Class
subclass of: PMO:00023838
MCID: MC00943943
PMOID: PMO:00019784
Subclass_of: Cell Cycle Proteins
Synonym: Maintenance Proteins, Minichromosome
Synonym: Minichromosome Maintenance Proteins [Chemical/Ingredient]
Tree Number: T6.10.3.64.12
database_cross_reference: MSH:D064110
database_cross_reference: NDFRT:N0000189495

Bacterial Proton-Translocating ATPases
type: Class
subclass of: PMO:00021903
MCID: MC00353505
PMOID: PMO:00019795
Subclass_of: Bacterial Proteins
Synonym: ATPases, Bacterial Proton-Translocating
Synonym: Bacterial F(1)F(0) ATPases
Synonym: Bacterial Proton Translocating ATPases
Synonym: Bacterial Proton-Translocating ATPases [Chemical/Ingredient]
Synonym: Proton-Translocating ATPases, Bacterial
Tree Number: T6.10.3.10.17
database_cross_reference: MSH:D025243
database_cross_reference: NDFRT:N0000169697

Thermosomes
type: Class
subclass of: PMO:00023859
MCID: MC00747747
PMOID: PMO:00019804
Subclass_of: Archaeal Proteins
Synonym: Thermosome
Synonym: Thermosome Proteins
Synonym: Thermosomes [Chemical/Ingredient]
Tree Number: T6.10.3.66.4
database_cross_reference: MSH:D056405
database_cross_reference: NDFRT:N0000180247

GTP-Binding Proteins
type: Class
subclass of: PMO:00022152
MCID: MC00043656
PMOID: PMO:00019815
Subclass_of: Carrier Proteins
Synonym: G Protein
Synonym: G Proteins
Synonym: G protein
Synonym: G protein (substance)
Synonym: G proteins
Synonym: G-Protein
Synonym: G-Proteins
Synonym: G-protein
Synonym: GTP Binding Protein
Synonym: GTP Binding Proteins
Tree Number: T6.10.3.12.19
database_cross_reference: AOD:0000020423
database_cross_reference: AOD:0000020427
database_cross_reference: AOD:0000028928
database_cross_reference: CHV:0000015908
database_cross_reference: CSP:2446-5300
database_cross_reference: CSP:2446-5350
database_cross_reference: FMA:61788
database_cross_reference: LCH_NW:sh89000191
database_cross_reference: MSH:D019204
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17458
database_cross_reference: NDFRT:N0000169817
database_cross_reference: SNMI:F-623C0
database_cross_reference: SNOMEDCT_US:22185007
database_cross_reference: UWDA:61788

Monomeric GTP-Binding Proteins
type: Class
subclass of: PMO:00021684
MCID: MC00259149
PMOID: PMO:00019816
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: G Proteins, Monomeric
Synonym: G-Proteins, Monomeric
Synonym: G-Proteins, Small
Synonym: GTP Binding Proteins, Monomeric
Synonym: GTP-Binding Proteins, Monomeric
Synonym: GTPases, Small
Synonym: Monomeric G Proteins
Synonym: Monomeric G-Proteins
Synonym: Monomeric GTP Binding Proteins
Synonym: Monomeric GTP-Binding Proteins [Chemical/Ingredient]
Tree Number: T6.10.2.33.23
Tree Number: T6.10.3.86.22
database_cross_reference: MSH:D020559
database_cross_reference: NCI:C18277
database_cross_reference: NDFRT:N0000170560

ran GTP-Binding Protein
type: Class
subclass of: PMO:00023628
MCID: MC00055203
PMOID: PMO:00019842
Subclass_of: Nuclear Proteins
Synonym: GTP-Binding Protein, ran
Synonym: Nuclear Protein, ras-Related
Synonym: RAS RELAT NUCLEAR PROTEIN
Synonym: TC A 004 PROTEIN
Synonym: TC4 Protein
Synonym: ran GTP Binding Protein
Synonym: ran GTP-Binding Protein [Chemical/Ingredient]
Synonym: ran Protein
Synonym: ran Proteins
Synonym: ras Related Nuclear Protein
Tree Number: T6.10.3.36.20
database_cross_reference: MSH:D020931
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170565

Heterotrimeric GTP-Binding Proteins
type: Class
subclass of: PMO:00021684
subclass of: PMO:00023060
MCID: MC00259366
PMOID: PMO:00019843
Subclass_of: Intracellular Signaling Peptides and Proteins
Subclass_of: Membrane Proteins
Synonym: G-Proteins, Heterotrimeric
Synonym: GTP-Binding Proteins, Heterotrimeric
Synonym: HET G PROTEINS
Synonym: Heterotrimeric G Protein
Synonym: Heterotrimeric G Proteins
Synonym: Heterotrimeric G-Proteins
Synonym: Heterotrimeric GTP Binding Proteins
Synonym: Heterotrimeric GTP-Binding Proteins [Chemical/Ingredient]
Tree Number: T6.10.2.33.28
Tree Number: T6.10.3.32.21
Tree Number: T6.10.3.86.27
database_cross_reference: MSH:D020962
database_cross_reference: NCI:C18281
database_cross_reference: NDFRT:N0000170550

Septins
type: Class
subclass of: PMO:00022569
MCID: MC00797854
PMOID: PMO:00019856
Subclass_of: Cytoskeletal Proteins
Synonym: Septins [Chemical/Ingredient]
Tree Number: T6.10.3.16.16
database_cross_reference: LCH_NW:sh2008004113
database_cross_reference: MSH:D058112
database_cross_reference: NDFRT:N0000182091

Adenosylhomocysteinase
type: Class
subclass of: Hydrolases
MCID: MC00019317
PMOID: PMO:00019863
Subclass_of: Hydrolases
Synonym: Adenosylhomocysteinase (substance)
Synonym: Adenosylhomocysteinase [Chemical/Ingredient]
Synonym: Hydrolase, S-adenosylhomocysteine
Synonym: S adenosylhomocysteine Hydrolase
Synonym: S adenosylhomocysteine Synthase
Synonym: S-adenosylhomocysteine Hydrolase
Synonym: S-adenosylhomocysteine Synthase
Synonym: SAH Hydrolase
Tree Number: T6.7.4.3.13
database_cross_reference: MSH:D043383
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167696
database_cross_reference: SNMI:F-6AAD0
database_cross_reference: SNOMEDCT_US:44931000

Isoenzymes
type: Class
subclass of: Enzymes
subclass of: PMO:00023860
MCID: MC00007078
PMOID: PMO:00019864
Subclass_of: Enzymes
Subclass_of: Protein Isoforms
Synonym: Isoenzyme
Synonym: Isoenzymes [Chemical/Ingredient]
Synonym: Isozyme
Synonym: Isozymes
Synonym: isoenzyme
Synonym: isoenzymes
Synonym: isozyme
Synonym: isozymes
Tree Number: T6.10.3.67.1
Tree Number: T6.7.4.4
database_cross_reference: AOD:0000001574
database_cross_reference: AOD:0000028224
database_cross_reference: CHV:0000006947
database_cross_reference: CSP:1042-6991
database_cross_reference: LCH:U002519
database_cross_reference: LCH_NW:sh85068633
database_cross_reference: LNC:LP20944-2
database_cross_reference: LNC:LP21397-2
database_cross_reference: MSH:D007527
database_cross_reference: NCI:C19567
database_cross_reference: NDFRT:N0000011443
database_cross_reference: PSY:26690
database_cross_reference: PSY:26750
database_cross_reference: SNM:F-20400
database_cross_reference: SNOMEDCT_US:30375003

Isomerases
type: Class
subclass of: Enzymes
MCID: MC00007092
PMOID: PMO:00019865
Subclass_of: Enzymes
Synonym: 6D0-6D4 ISOMERASES
Synonym: EC 5
Synonym: ISOMERASES
Synonym: Isomerase
Synonym: Isomerase (substance)
Synonym: Isomerase, NOS
Synonym: Isomerases [Chemical/Ingredient]
Synonym: isomerase
Synonym: isomerases
Tree Number: T6.7.4.5
database_cross_reference: AOD:0000018345
database_cross_reference: CHV:0000006955
database_cross_reference: CSP:1638-3131
database_cross_reference: LCH:U002521
database_cross_reference: LCH_NW:sh85068646
database_cross_reference: LNC:LP21399-8
database_cross_reference: MSH:D007535
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16759
database_cross_reference: NDFRT:N0000168082
database_cross_reference: RCD:Xa9tc
database_cross_reference: SNM:F-21940
database_cross_reference: SNMI:F-6D000
database_cross_reference: SNOMEDCT_US:26160000

cis-trans-Isomerases
type: Class
subclass of: Isomerases
MCID: MC00163950
PMOID: PMO:00019867
Subclass_of: Isomerases
Synonym: Isomerases, cis trans
Synonym: Isomerases, cis-trans
Synonym: cis trans Isomerases
Synonym: cis-trans Isomerases
Synonym: cis-trans-Isomerases [Chemical/Ingredient]
Tree Number: T6.7.4.5.2
database_cross_reference: MSH:D019745
database_cross_reference: NDFRT:N0000168093

Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 4
type: Class
subclass of: PMO:00022601
MCID: MC01047406
PMOID: PMO:00019870
Subclass_of: DNA-Binding Proteins
Synonym: PIN4 Protein
Synonym: Parvulin 14
Synonym: Parvulin 17
Synonym: Parvulin-14
Synonym: Parvulin-17
Synonym: Peptidyl Prolyl Cis Trans Isomerase NIMA Interacting 4
Synonym: Peptidyl Prolyl Cis Trans Isomerase Pin4
Synonym: Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 4 [Chemical/Ingredient]
Synonym: Peptidyl-Prolyl Cis-Trans Isomerase Pin4
Tree Number: T6.10.3.19.7
database_cross_reference: MSH:D000072621
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000193080

Immunophilins
type: Class
subclass of: PMO:00023691
MCID: MC00184353
PMOID: PMO:00019871
Subclass_of: Receptors, Drug
Synonym: Immunophilins [Chemical/Ingredient]
Tree Number: T6.10.3.47.2
database_cross_reference: MSH:D020104
database_cross_reference: NDFRT:N0000170172

Intramolecular Oxidoreductases
type: Class
subclass of: Isomerases
MCID: MC00163951
PMOID: PMO:00019877
Subclass_of: Isomerases
Synonym: Intramolecular Oxidoreductases [Chemical/Ingredient]
Synonym: Oxidoreductases, Intramolecular
Tree Number: T6.7.4.5.3
database_cross_reference: MSH:D019746
database_cross_reference: NDFRT:N0000168083

Peroxisomal Bifunctional Enzyme
type: Class
subclass of: PMO:00020867
MCID: MC00943909
PMOID: PMO:00019887
Subclass_of: Multifunctional Enzymes
Synonym: 2-Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Dehydrogenase-delta 3, delta 2-Enoyl-CoA Isomerase
Synonym: Bifunctional Enzyme, L-Peroxisomal
Synonym: Bifunctional Enzyme, Peroxisomal
Synonym: Dehydrogenase, Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA
Synonym: Enoyl CoA Hydratase 3 Hydroxyacyl CoA Dehydrogenase
Synonym: Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA Dehydrogenase
Synonym: Hydratase-3-Hydroxyacyl-CoA Dehydrogenase, Enoyl-CoA
Synonym: Hydratase-Dehydrogenase-Epimerase, Peroxisomal
Synonym: L Bifunctional Enzyme
Synonym: L Peroxisomal Bifunctional Enzyme
Tree Number: T6.7.4.18.12
database_cross_reference: MSH:D063994
database_cross_reference: NDFRT:N0000189483

Intramolecular Transferases
type: Class
subclass of: Isomerases
MCID: MC00163955
PMOID: PMO:00019890
Subclass_of: Isomerases
Synonym: Intramolecular Transferases [Chemical/Ingredient]
Synonym: Mutase
Synonym: Mutase (substance)
Synonym: Mutases
Synonym: Transferases, Intramolecular
Synonym: mutase
Tree Number: T6.7.4.5.4
database_cross_reference: CHV:0000038372
database_cross_reference: MSH:D019751
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168114
database_cross_reference: RCD:Xa9u1
database_cross_reference: SNOMEDCT_US:130945002

Intramolecular Lyases
type: Class
subclass of: Isomerases
MCID: MC00163956
PMOID: PMO:00019900
Subclass_of: Isomerases
Synonym: Intramolecular Lyases [Chemical/Ingredient]
Synonym: Lyases, Intramolecular
Tree Number: T6.7.4.5.5
database_cross_reference: MSH:D019753
database_cross_reference: NDFRT:N0000168102

Racemases and Epimerases
type: Class
subclass of: Isomerases
MCID: MC00164028
PMOID: PMO:00019902
Subclass_of: Isomerases
Synonym: Epimerases and Racemases
Synonym: RACEMASES EPIMERASES
Synonym: Racemases and Epimerases [Chemical/Ingredient]
Tree Number: T6.7.4.5.6
database_cross_reference: MSH:D019998
database_cross_reference: NDFRT:N0000168097

DNA Topoisomerases
type: Class
subclass of: Isomerases
MCID: MC00337814
PMOID: PMO:00019907
Subclass_of: Isomerases
Synonym: DNA Topoisomerases [Chemical/Ingredient]
Synonym: DNA topoisomerases
Synonym: Topoisomerases, DNA
Tree Number: T6.7.4.5.7
database_cross_reference: LCH_NW:sh99000716
database_cross_reference: MSH:D026942
database_cross_reference: NDFRT:N0000168104

DNA Gyrase
type: Class
subclass of: PMO:00021903
MCID: MC00337817
PMOID: PMO:00019909
Subclass_of: Bacterial Proteins
Synonym: DNA Gyrase [Chemical/Ingredient]
Synonym: DNA gyrase
Synonym: DNA-Gyrase
Synonym: DNA-gyrase
Tree Number: T6.10.3.10.18
database_cross_reference: CSP:2101-0657
database_cross_reference: MSH:D027081
database_cross_reference: NDFRT:N0000168107
database_cross_reference: SNMI:F-6D4B8
database_cross_reference: SNOMEDCT_US:3465008

DNA Topoisomerase IV
type: Class
subclass of: PMO:00021903
MCID: MC00041983
PMOID: PMO:00019910
Subclass_of: Bacterial Proteins
Synonym: DNA Topoisomerase IV [Chemical/Ingredient]
Synonym: Topo IV
Synonym: Topoisomerase IV
Synonym: Topoisomerase IV, DNA
Tree Number: T6.10.3.10.19
database_cross_reference: MSH:D027101
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17405
database_cross_reference: NDFRT:N0000168108

Ligases
type: Class
subclass of: Enzymes
MCID: MC00007570
PMOID: PMO:00019912
Subclass_of: Enzymes
Synonym: 6E0-6E3 LIGASES
Synonym: EC 6
Synonym: LIGASES
Synonym: Ligase
Synonym: Ligase (substance)
Synonym: Ligase, NOS
Synonym: Ligases [Chemical/Ingredient]
Synonym: Synthetase
Synonym: Synthetases
Synonym: ligase
Tree Number: T6.7.4.6
database_cross_reference: AOD:0000018349
database_cross_reference: AOD:0000018351
database_cross_reference: CHV:0000007419
database_cross_reference: CSP:1734-9599
database_cross_reference: LCH:U002694
database_cross_reference: LCH_NW:sh85076869
database_cross_reference: MSH:D008025
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16796
database_cross_reference: NDFRT:N0000167746
database_cross_reference: RCD:Xa9tn
database_cross_reference: SNM:F-22120
database_cross_reference: SNMI:F-6C410
database_cross_reference: SNMI:F-6E000
database_cross_reference: SNOMEDCT_US:1672007
database_cross_reference: SNOMEDCT_US:87222001

Polynucleotide Ligases
type: Class
subclass of: Ligases
MCID: MC00010445
PMOID: PMO:00019913
Subclass_of: Ligases
Synonym: Ligases, Polynucleotide
Synonym: Polynucleotide Ligases [Chemical/Ingredient]
Synonym: Polynucleotide Synthetases
Synonym: Synthetases, Polynucleotide
Synonym: polynucleotide ligase
Synonym: polynucleotide synthetases
Tree Number: T6.7.4.6.1
database_cross_reference: AOD:0000018354
database_cross_reference: GO:GO:0003910
database_cross_reference: GO:GO:0003911
database_cross_reference: MSH:D011118
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167747

DNA Ligases
type: Class
subclass of: PMO:00020864
MCID: MC00010410
PMOID: PMO:00019914
Subclass_of: DNA Repair Enzymes
Synonym: DNA Joinases
Synonym: DNA Ligase
Synonym: DNA Ligases [Chemical/Ingredient]
Synonym: DNA ligases
Synonym: EC 6.5.1.1
Synonym: Joinases, DNA
Synonym: Ligases, DNA
Synonym: Ligases, Polydeoxyribonucleotide
Synonym: Polydeoxyribonucleotide Ligases
Synonym: Polydeoxyribonucleotide Synthase
Tree Number: T6.7.4.16.5
database_cross_reference: LCH_NW:sh89005027
database_cross_reference: MSH:D011088
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C105960
database_cross_reference: NDFRT:N0000168006

Carbon-Oxygen Ligases
type: Class
subclass of: Ligases
MCID: MC00163941
PMOID: PMO:00019917
Subclass_of: Ligases
Synonym: C O LIGASES
Synonym: Carbon Oxygen Ligases
Synonym: Carbon-Oxygen Ligases [Chemical/Ingredient]
Synonym: Ligases, Carbon-Oxygen
Synonym: carbon oxgen ligase
Tree Number: T6.7.4.6.2
database_cross_reference: CSP:1734-9599
database_cross_reference: MSH:D019729
database_cross_reference: NDFRT:N0000167775

Carbon-Sulfur Ligases
type: Class
subclass of: Ligases
MCID: MC00163942
PMOID: PMO:00019935
Subclass_of: Ligases
Synonym: C S LIGASES
Synonym: Carbon Sulfur Ligases
Synonym: Carbon-Sulfur Ligases [Chemical/Ingredient]
Synonym: Ligases, Carbon-Sulfur
Tree Number: T6.7.4.6.3
database_cross_reference: MSH:D019730
database_cross_reference: NDFRT:N0000167749

Carbon-Nitrogen Ligases
type: Class
subclass of: Ligases
MCID: MC00163943
PMOID: PMO:00019939
Subclass_of: Ligases
Synonym: C N LIGASES
Synonym: Carbon Nitrogen Ligases
Synonym: Carbon-Nitrogen Ligases [Chemical/Ingredient]
Synonym: Ligases, Carbon-Nitrogen
Synonym: carbon nitrogen ligase
Tree Number: T6.7.4.6.4
database_cross_reference: CSP:0556-8429
database_cross_reference: MSH:D019731
database_cross_reference: NDFRT:N0000167762

Carbon-Carbon Ligases
type: Class
subclass of: Ligases
MCID: MC00163946
PMOID: PMO:00019952
Subclass_of: Ligases
Synonym: C C LIGASES
Synonym: Carbon Carbon Ligases
Synonym: Carbon-Carbon Ligases [Chemical/Ingredient]
Synonym: Ligases, Carbon-Carbon
Synonym: carbon carbon ligase
Tree Number: T6.7.4.6.5
database_cross_reference: CSP:0553-2842
database_cross_reference: MSH:D019735
database_cross_reference: NDFRT:N0000167753

Acetyl-CoA Carboxylase
type: Class
subclass of: PMO:00020867
MCID: MC00000198
PMOID: PMO:00019953
Subclass_of: Multifunctional Enzymes
Synonym: Acetyl CoA Carboxylase
Synonym: Acetyl Coenzyme A Carboxylase
Synonym: Acetyl coenzyme A carboxylase
Synonym: Acetyl-CoA Carboxylase [Chemical/Ingredient]
Synonym: Acetyl-CoA carboxylase
Synonym: Acetyl-CoA carboxylase (substance)
Synonym: Acetyl-CoA:carbon-dioxide ligase (ADP-forming)
Synonym: Acetyl-coenzyme A carboxylase
Synonym: Acetyl-coenzyme A carboxylase (substance)
Synonym: Carboxylase, Acetyl-CoA
Tree Number: T6.7.4.18.1
database_cross_reference: CHV:0000000611
database_cross_reference: CSP:0553-4715
database_cross_reference: MSH:D000103
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167754
database_cross_reference: SNM:F-20020
database_cross_reference: SNMI:F-6E3B8
database_cross_reference: SNOMEDCT_US:77832006

Polyketide Synthases
type: Class
subclass of: Multienzyme Complexes
MCID: MC00035488
PMOID: PMO:00019955
Subclass_of: Multienzyme Complexes
Synonym: PKS enzyme
Synonym: Polyketide Synthases [Chemical/Ingredient]
Synonym: Synthases, Polyketide
Synonym: polyketide synthase
Tree Number: T6.7.4.8.12
database_cross_reference: CSP:5001-0023
database_cross_reference: MSH:D048630
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167756

Ubiquitin-Protein Ligase Complexes
type: Class
subclass of: Ligases
MCID: MC00420924
PMOID: PMO:00019956
Subclass_of: Ligases
Synonym: Complexes, Ubiquitin-Protein Ligase
Synonym: Ligase Complexes, Ubiquitin-Protein
Synonym: Ubiquitin Protein Ligase
Synonym: Ubiquitin Protein Ligase Complex
Synonym: Ubiquitin Protein Ligase Complexes
Synonym: Ubiquitin-Protein Ligase Complexes [Chemical/Ingredient]
Tree Number: T6.7.4.6.6
database_cross_reference: MSH:D043743
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26065
database_cross_reference: NDFRT:N0000167757

Tripartite Motif-Containing Protein 28
type: Class
subclass of: PMO:00021875
MCID: MC00502520
PMOID: PMO:00019960
Subclass_of: Tripartite Motif Proteins
Synonym: KAP1
Synonym: KRAB-ASSOCIATED PROTEIN 1
Synonym: PPP1R157
Synonym: RNF96
Synonym: TF1B
Synonym: TIF1B
Synonym: TRANSCRIPTIONAL INTERMEDIARY FACTOR 1-BETA
Synonym: TRIM28
Synonym: TRIM28 gene
Synonym: TRIPARTITE MOTIF-CONTAINING PROTEIN 28
Tree Number: T6.10.3.3.3
database_cross_reference: HGNC:HGNC:16384
database_cross_reference: MTH:NOCODE
database_cross_reference: NCBI_Gene:10155
database_cross_reference: NCBI_Gene:1033
database_cross_reference: OMIM:601742

F-Box-WD Repeat-Containing Protein 7
type: Class
subclass of: PMO:00023838
PMOID: PMO:00019962
Subclass_of: Cell Cycle Proteins
Tree Number: T6.10.3.64.2

Cullin Proteins
type: Class
subclass of: PMO:00023838
MCID: MC00421643
PMOID: PMO:00019963
Subclass_of: Cell Cycle Proteins
Synonym: Cullin Domain Protein
Synonym: Cullin Domain Proteins
Synonym: Cullin Protein
Synonym: Cullin Proteins [Chemical/Ingredient]
Synonym: Cullins
Tree Number: T6.10.3.64.10
database_cross_reference: MSH:D044842
database_cross_reference: NDFRT:N0000170194

Neuronal Apoptosis-Inhibitory Protein
type: Class
subclass of: PMO:00023612
MCID: MC00102191
PMOID: PMO:00019967
Subclass_of: Nerve Tissue Proteins
Synonym: Apoptosis-Inhibitory Protein, Neuronal
Synonym: BIRC1
Synonym: Baculoviral IAP Repeat-Containing Protein 1
Synonym: NAIP
Synonym: NAIP Protein
Synonym: Neuronal Apoptosis Inhibitory Protein
Synonym: Neuronal Apoptosis-Inhibitory Protein [Chemical/Ingredient]
Synonym: neuronal apoptosis inhibitory protein
Tree Number: T6.10.3.35.25
database_cross_reference: MSH:D051616
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C20928
database_cross_reference: NDFRT:N0000170495

Proto-Oncogene Proteins c-mdm2
type: Class
subclass of: PMO:00023628
MCID: MC00052562
PMOID: PMO:00019969
Subclass_of: Nuclear Proteins
Synonym: C MDM 002 PROTO ONCOGENE PROTEIN
Synonym: Double Minute 2 Protein
Synonym: MDMX Protein
Synonym: Mdm 2 Protein
Synonym: Mdm-2 Protein
Synonym: Mdm2 Protein
Synonym: Murine Double Minute 2 Protein
Synonym: PROTO ONCOGENE PROTEINS C MDM 002
Synonym: Proto Oncogene Proteins c mdm2
Synonym: Proto-Oncogene Protein, c-mdm2
Tree Number: T6.10.3.36.30
database_cross_reference: MSH:D051736
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169211

Fanconi Anemia Complementation Group L Protein
type: Class
subclass of: PMO:00023919
MCID: MC00543515
PMOID: PMO:00019971
Subclass_of: Fanconi Anemia Complementation Group Proteins
Synonym: FANCL Protein
Synonym: Fanconi Anemia Complementation Group L Protein [Chemical/Ingredient]
Synonym: Fanconi Anemia Group L Complementing Protein
Synonym: Fanconi Anemia Group L Protein
Synonym: PHD Finger Protein 9
Synonym: Ubiquitin Ligase Protein PHF9
Tree Number: T6.10.3.91.10
database_cross_reference: MSH:D052240
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169412

Anaphase-Promoting Complex-Cyclosome
type: Class
subclass of: PMO:00023838
MCID: MC00164653
PMOID: PMO:00019973
Subclass_of: Cell Cycle Proteins
Synonym: Anaphase Promoting Complex
Synonym: Anaphase-Promoting Complex-Cyclosome [Chemical/Ingredient]
Synonym: anaphase-promoting complex
Tree Number: T6.10.3.64.14
database_cross_reference: MSH:D064173
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000189423

Lyases
type: Class
subclass of: Enzymes
MCID: MC00007726
PMOID: PMO:00019986
Subclass_of: Enzymes
Synonym: 6C0-6C9 LYASES
Synonym: EC 4
Synonym: LYASES
Synonym: Lyase
Synonym: Lyase (substance)
Synonym: Lyase, NOS
Synonym: Lyases [Chemical/Ingredient]
Synonym: lyase
Synonym: lyases
Tree Number: T6.7.4.7
database_cross_reference: AOD:0000018357
database_cross_reference: CHV:0000007586
database_cross_reference: CSP:1771-6000
database_cross_reference: LCH:U002752
database_cross_reference: LCH_NW:sh85079067
database_cross_reference: MSH:D008190
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16804
database_cross_reference: NDFRT:N0000008273
database_cross_reference: RCD:Xa9wp
database_cross_reference: SNM:F-22160
database_cross_reference: SNMI:F-6C000
database_cross_reference: SNOMEDCT_US:21533003

Ferrochelatase
type: Class
subclass of: Lyases
subclass of: PMO:00023874
MCID: MC00005047
PMOID: PMO:00019987
Subclass_of: Lyases
Subclass_of: Mitochondrial Proteins
Synonym: Chelatase, Porphyrin-Metal
Synonym: FERROCHELATASE
Synonym: Ferro-Lyase, Protoheme
Synonym: Ferrochelatase (substance)
Synonym: Ferrochelatase [Chemical/Ingredient]
Synonym: Haem synthetase
Synonym: Hem synthetase
Synonym: Heme Synthetase
Synonym: Heme synthetase
Synonym: Heme synthetase (substance)
Tree Number: T6.10.3.74.4
Tree Number: T6.7.4.7.1
database_cross_reference: CHV:0000004975
database_cross_reference: CSP:0156-0209
database_cross_reference: CSP:0814-7550
database_cross_reference: CSP:4007-0044
database_cross_reference: LNC:LP15569-4
database_cross_reference: LNC:MTHU010746
database_cross_reference: MSH:D005294
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168007
database_cross_reference: RCD:X80L7
database_cross_reference: RCD:X80Ut
database_cross_reference: SNM:F-211Y0
database_cross_reference: SNMI:F-6C908
database_cross_reference: SNOMEDCT_US:259709006
database_cross_reference: SNOMEDCT_US:57960008

Carbon-Sulfur Lyases
type: Class
subclass of: Lyases
MCID: MC00012386
PMOID: PMO:00019988
Subclass_of: Lyases
Synonym: C S LYASES
Synonym: Carbon Sulfur Lyases
Synonym: Carbon-Sulfur Lyases [Chemical/Ingredient]
Synonym: Lyases, Carbon-Sulfur
Synonym: Sulfhydrases
Synonym: carbon sulfur lyase
Tree Number: T6.7.4.7.2
database_cross_reference: CSP:0557-9333
database_cross_reference: MSH:D013437
database_cross_reference: NDFRT:N0000168070

Carbon-Carbon Lyases
type: Class
subclass of: Lyases
MCID: MC00163957
PMOID: PMO:00019991
Subclass_of: Lyases
Synonym: C C LYASES
Synonym: Carbon Carbon Lyases
Synonym: Carbon-Carbon Lyases [Chemical/Ingredient]
Synonym: Carbon-carbon lyase
Synonym: Carbon-carbon lyase (biological function)
Synonym: Carbon-carbon lyase (biological function) (substance)
Synonym: Carbon-carbon lyase (substance)
Synonym: Carbon-carbon lyase -RETIRED-
Synonym: Lyases, Carbon-Carbon
Synonym: carbon carbon lyase
Tree Number: T6.7.4.7.3
database_cross_reference: CSP:0554-8449
database_cross_reference: MSH:D019755
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168041
database_cross_reference: SNOMEDCT_US:124635002
database_cross_reference: SNOMEDCT_US:130933006

Deoxyribodipyrimidine Photo-Lyase
type: Class
subclass of: PMO:00020864
MCID: MC00004109
PMOID: PMO:00020011
Subclass_of: DNA Repair Enzymes
Synonym: DNA Photolyase
Synonym: DNA Photolyases
Synonym: DNA Photoreactivating Enzyme
Synonym: Deoxyribocyclobutadipyrimidine pyrimidine-lyase
Synonym: Deoxyribodipyrimidine Photo Lyase
Synonym: Deoxyribodipyrimidine Photo-Lyase [Chemical/Ingredient]
Synonym: Deoxyribodipyrimidine Photolyase
Synonym: Deoxyribodipyrimidine photo-lyase
Synonym: Deoxyribodipyrimidine photo-lyase (substance)
Synonym: Photo-Lyase, Deoxyribodipyrimidine
Tree Number: T6.7.4.16.4
database_cross_reference: MSH:D004255
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168049
database_cross_reference: SNMI:F-6C500
database_cross_reference: SNOMEDCT_US:37023004

Anthranilate Synthase
type: Class
subclass of: Multienzyme Complexes
MCID: MC00000983
PMOID: PMO:00020013
Subclass_of: Multienzyme Complexes
Synonym: Anthranilate Synthase [Chemical/Ingredient]
Synonym: Anthranilate Synthetase
Synonym: Anthranilate synthase
Synonym: Anthranilate synthase (substance)
Synonym: Chorismate pyruvate-lyase (amino-accepting)
Synonym: Synthase, Anthranilate
Synonym: Synthetase, Anthranilate
Tree Number: T6.7.4.8.2
database_cross_reference: MSH:D000878
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168047
database_cross_reference: SNMI:F-6C4B0
database_cross_reference: SNOMEDCT_US:56455005

Carbon-Oxygen Lyases
type: Class
subclass of: Lyases
MCID: MC00163958
PMOID: PMO:00020017
Subclass_of: Lyases
Synonym: C O LYASES
Synonym: Carbon Oxygen Lyases
Synonym: Carbon-Oxygen Lyases [Chemical/Ingredient]
Synonym: Carbon-oxygen lyase
Synonym: Carbon-oxygen lyase (biological function)
Synonym: Carbon-oxygen lyase (biological function) (substance)
Synonym: Carbon-oxygen lyase (substance)
Synonym: Carbon-oxygen lyase -RETIRED-
Synonym: Lyases, Carbon-Oxygen
Synonym: carbon oxygen lyase
Tree Number: T6.7.4.7.4
database_cross_reference: CSP:0557-8730
database_cross_reference: MSH:D019757
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008169
database_cross_reference: SNOMEDCT_US:124643007
database_cross_reference: SNOMEDCT_US:130936003

Iron Regulatory Protein 1
type: Class
subclass of: PMO:00023887
MCID: MC00133970
PMOID: PMO:00020020
Subclass_of: Iron-Regulatory Proteins
Synonym: ACO1 Protein
Synonym: Aconitase 1, Soluble
Synonym: Ferritin Repressor Protein
Synonym: IRE BP1
Synonym: IRE-BP1
Synonym: IRON REGULATORY PROTEIN A 1
Synonym: IRP 1 Protein
Synonym: IRP-1 Protein
Synonym: IRP1 Protein
Synonym: Iron Regulatory Protein 1 [Chemical/Ingredient]
Tree Number: T6.10.3.82.1
database_cross_reference: MSH:D035941
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169653

Iron Regulatory Protein 2
type: Class
subclass of: PMO:00023887
MCID: MC00100014
PMOID: PMO:00020021
Subclass_of: Iron-Regulatory Proteins
Synonym: IRE-BP2
Synonym: IREB2 Protein
Synonym: IRON REGULATORY PROTEIN A 2
Synonym: IRP 2 RNA binding protein
Synonym: IRP-2 RNA-binding protein
Synonym: IRP2 Protein
Synonym: Iron Regulatory Protein 2 [Chemical/Ingredient]
Synonym: Iron-Responsive-Element Binding Protein 2
Synonym: RNA-binding protein, IRP-2
Tree Number: T6.10.3.82.2
database_cross_reference: MSH:D035942
database_cross_reference: NDFRT:N0000169651

Carbonic Anhydrase IX
type: Class
subclass of: PMO:00023060
subclass of: PMO:00024309
MCID: MC00087488
PMOID: PMO:00020024
Subclass_of: Antigens, Neoplasm
Subclass_of: Membrane Proteins
Synonym: CA IX enzyme, human
Synonym: CA-IX
Synonym: CA9 protein, human
Synonym: Carbonic Anhydrase 9
Synonym: Carbonic Dehydratase IX
Synonym: G250 protein, human
Synonym: MN antigen, human
Synonym: Membrane Antigen MN
Synonym: P54/58N
Synonym: RCC-Associated Protein G250
Tree Number: T6.10.3.32.2
Tree Number: T6.13.3.7.1
database_cross_reference: MSH:C089226
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C104052

Mitochondrial Trifunctional Protein
type: Class
subclass of: PMO:00020867
subclass of: PMO:00023060
subclass of: PMO:00023874
MCID: MC00943910
PMOID: PMO:00020032
Subclass_of: Membrane Proteins
Subclass_of: Mitochondrial Proteins
Subclass_of: Multifunctional Enzymes
Synonym: FA beta-OMC
Synonym: Mitochondrial Fatty Acid beta Oxidation Trifunctional Protein
Synonym: Mitochondrial Fatty Acid beta-Oxidation Trifunctional Protein
Synonym: Mitochondrial Long Chain Enoyl CoA Hydratase 3 Hydroxyacyl CoA Dehydrogenase 3 Ketoacyl CoA Thiolase Trifunctional Protein
Synonym: Mitochondrial Trifunctional Protein [Chemical/Ingredient]
Synonym: Trifunctional Protein, Mitochondrial
Tree Number: T6.10.3.32.51
Tree Number: T6.10.3.74.11
Tree Number: T6.7.4.18.11
database_cross_reference: MSH:D063991
database_cross_reference: NDFRT:N0000189484

Tryptophan Synthase
type: Class
subclass of: Multienzyme Complexes
MCID: MC00013178
PMOID: PMO:00020038
Subclass_of: Multienzyme Complexes
Synonym: L-Serine hydro-lyase (adding indoleglycerol-phosphate)
Synonym: Synthase, Tryptophan
Synonym: Synthetase, Tryptophan
Synonym: Tryptophan Synthase [Chemical/Ingredient]
Synonym: Tryptophan Synthetase
Synonym: Tryptophan desmolase
Synonym: Tryptophan synthase
Synonym: Tryptophan synthase (substance)
Synonym: Tryptophan synthetase
Synonym: tryptophan desmolase
Tree Number: T6.7.4.8.8
database_cross_reference: CSP:0816-6280
database_cross_reference: MSH:D014367
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168033
database_cross_reference: SNM:F-23450
database_cross_reference: SNMI:F-6C5A0
database_cross_reference: SNOMEDCT_US:70213008

Peroxisomal Multifunctional Protein-2
type: Class
subclass of: PMO:00020867
MCID: MC00924325
PMOID: PMO:00020042
Subclass_of: Multifunctional Enzymes
Synonym: 17 beta Hydroxysteroid Dehydrogenase 4
Synonym: 17-beta-Hydroxysteroid Dehydrogenase 4
Synonym: 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
Synonym: 4, 17-beta-Hydroxysteroid Dehydrogenase
Synonym: Dehydrogenase 4, 17-beta-Hydroxysteroid
Synonym: Multifunctional Protein-2, Peroxisomal
Synonym: Peroxisomal Multifunctional Enzyme Type 2
Synonym: Peroxisomal Multifunctional Protein 2
Synonym: Peroxisomal Multifunctional Protein-2 [Chemical/Ingredient]
Tree Number: T6.7.4.18.13
database_cross_reference: MSH:D064029
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000189460

DNA-(Apurinic or Apyrimidinic Site) Lyase
type: Class
subclass of: PMO:00020864
MCID: MC00338055
PMOID: PMO:00020047
Subclass_of: DNA Repair Enzymes
Synonym: AP Endonuclease
Synonym: AP Lyase
Synonym: AP endonuclease class I
Synonym: AP lyase
Synonym: Apurine Apyrimidine Endonuclease
Synonym: Apurine-Apyrimidine Endonuclease
Synonym: Apurinic DNA Endonuclease
Synonym: Apurinic Endonuclease
Synonym: DNA Endonuclease, Apurinic
Synonym: DNA Lyase (Apurinic or Apyrimidinic)
Tree Number: T6.7.4.16.7
database_cross_reference: MSH:D043603
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168040
database_cross_reference: SNMI:F-6A688
database_cross_reference: SNOMEDCT_US:130855002
database_cross_reference: SNOMEDCT_US:57450005

Carbon-Nitrogen Lyases
type: Class
subclass of: Lyases
MCID: MC00163959
PMOID: PMO:00020048
Subclass_of: Lyases
Synonym: C N LYASES
Synonym: Carbon Nitrogen Lyases
Synonym: Carbon-Nitrogen Lyases [Chemical/Ingredient]
Synonym: Carbon-nitrogen lyase
Synonym: Carbon-nitrogen lyase (biological function)
Synonym: Carbon-nitrogen lyase (biological function) (substance)
Synonym: Carbon-nitrogen lyase (substance)
Synonym: Carbon-nitrogen lyase -RETIRED-
Synonym: Lyases, Carbon-Nitrogen
Synonym: carbon nitrogen lyase
Tree Number: T6.7.4.7.5
database_cross_reference: CSP:4000-0139
database_cross_reference: MSH:D019759
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168008
database_cross_reference: SNOMEDCT_US:124647008
database_cross_reference: SNOMEDCT_US:130938002

Phosphorus-Oxygen Lyases
type: Class
subclass of: Lyases
MCID: MC00163961
PMOID: PMO:00020060
Subclass_of: Lyases
Synonym: Lyases, Phosphorus-Oxygen
Synonym: P O LYASES
Synonym: Phosphorus Oxygen Lyases
Synonym: Phosphorus-Oxygen Lyases [Chemical/Ingredient]
Synonym: Phosphorus-oxygen lyase
Synonym: Phosphorus-oxygen lyase (biological function)
Synonym: Phosphorus-oxygen lyase (biological function) (substance)
Synonym: Phosphorus-oxygen lyase (substance)
Synonym: Phosphorus-oxygen lyase -RETIRED-
Synonym: phosphorus oxygen lyase
Tree Number: T6.7.4.7.6
database_cross_reference: CSP:2302-4946
database_cross_reference: MSH:D019761
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168068
database_cross_reference: SNOMEDCT_US:124655001
database_cross_reference: SNOMEDCT_US:130942004

Adenylyl Cyclases
type: Class
subclass of: PMO:00021684
MCID: MC00000381
PMOID: PMO:00020061
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: 3',5' cyclic AMP Synthetase
Synonym: 3',5'-Cyclic AMP synthetase
Synonym: 3',5'-cyclic AMP Synthetase
Synonym: 3,5 cyclic AMP synthetase
Synonym: AMP Synthetase, 3',5'-cyclic
Synonym: ATP pyrophosphate-lyase (cyclizing)
Synonym: Adenyl Cyclase
Synonym: Adenyl cyclase
Synonym: Adenylate Cyclase
Synonym: Adenylate cyclase
Tree Number: T6.10.2.33.11
Tree Number: T6.10.3.86.10
database_cross_reference: AOD:0000018360
database_cross_reference: AOD:0000018362
database_cross_reference: CHV:0000000731
database_cross_reference: CSP:2112-1321
database_cross_reference: LCH_NW:sh85000855
database_cross_reference: MSH:D000262
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170425
database_cross_reference: SNM:F-20170
database_cross_reference: SNMI:F-6C8E8
database_cross_reference: SNOMEDCT_US:4105008

Guanylate Cyclase
type: Class
subclass of: PMO:00021684
MCID: MC00005882
PMOID: PMO:00020063
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Cyclase, Deoxyguanylate
Synonym: Cyclase, Guanyl
Synonym: Cyclase, Guanylate
Synonym: Cyclase, Guanylyl
Synonym: Cyclase, Inosinate
Synonym: Deoxyguanylate Cyclase
Synonym: EC 4.6.1.2
Synonym: GTP pyrophosphate-lyase (cyclizing)
Synonym: Guanyl Cyclase
Synonym: Guanyl cyclase
Tree Number: T6.10.2.33.12
Tree Number: T6.10.3.86.11
database_cross_reference: AOD:0000018382
database_cross_reference: CHV:0000005734
database_cross_reference: CSP:2112-1534
database_cross_reference: LCH_NW:sh2002000839
database_cross_reference: MSH:D006162
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16653
database_cross_reference: NDFRT:N0000170499
database_cross_reference: SNMI:F-6C8F0
database_cross_reference: SNOMEDCT_US:28954008

Anthranilate Phosphoribosyltransferase
type: Class
subclass of: Multienzyme Complexes
MCID: MC00000982
PMOID: PMO:00020068
Subclass_of: Multienzyme Complexes
Synonym: Anthranilate PR Transferase
Synonym: Anthranilate Phosphoribosyltransferase [Chemical/Ingredient]
Synonym: Anthranilate phosphoribosyltransferase
Synonym: Anthranilate phosphoribosyltransferase (substance)
Synonym: N-(5-Phospho-D-ribosyl)-anthranilate:pyrophosphate phospho-alpha-D-ribosyltransferase
Synonym: PR Transferase, Anthranilate
Synonym: Phosphoribosyl-anthranilate pyrophosphorylase
Synonym: Phosphoribosylanthranilate Pyrophosphorylase
Synonym: Phosphoribosyltransferase, Anthranilate
Synonym: Pyrophosphorylase, Phosphoribosylanthranilate
Tree Number: T6.7.4.8.1
database_cross_reference: MSH:D000877
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168351
database_cross_reference: SNMI:F-68BF8
database_cross_reference: SNOMEDCT_US:41372005

Prostaglandin-Endoperoxide Synthases
type: Class
subclass of: Multienzyme Complexes
MCID: MC00010741
PMOID: PMO:00020069
Subclass_of: Multienzyme Complexes
Synonym: (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Synonym: Arachidonic Acid Cyclooxygenase
Synonym: COX
Synonym: Cyclase, Hydroperoxide
Synonym: Cyclo Oxygenase
Synonym: Cyclo-Oxygenase
Synonym: Cyclo-Oxygenase (COX)
Synonym: Cyclo-Oxygenase, Fatty Acid
Synonym: Cyclo-Oxygenase, Prostaglandin
Synonym: Cyclooxygenase
Tree Number: T6.7.4.8.5
database_cross_reference: AOD:0000018401
database_cross_reference: CHV:0000010214
database_cross_reference: CSP:2182-7972
database_cross_reference: LCH_NW:sh96008414
database_cross_reference: MSH:D011451
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17015
database_cross_reference: NDFRT:N0000167859
database_cross_reference: SNM:F-22970
database_cross_reference: SNMI:F-67448
database_cross_reference: SNOMEDCT_US:3710008

Electron Transport Chain Complex Proteins
type: Class
subclass of: Multienzyme Complexes
subclass of: PMO:00023060
MCID: MC00421675
PMOID: PMO:00020072
Subclass_of: Membrane Proteins
Subclass_of: Multienzyme Complexes
Synonym: Electron Transport Chain Complex Proteins [Chemical/Ingredient]
Tree Number: T6.10.3.32.30
Tree Number: T6.7.4.8.9
database_cross_reference: MSH:D045222
database_cross_reference: NDFRT:N0000167737

Electron-Transferring Flavoproteins
type: Class
subclass of: PMO:00022858
MCID: MC00025758
PMOID: PMO:00020073
Subclass_of: Flavoproteins
Synonym: ET Flavoprotein
Synonym: ETF ubiquinone oxidoreductase
Synonym: Electron Transfer Flavoprotein
Synonym: Electron Transferring Flavoprotein
Synonym: Electron Transferring Flavoproteins
Synonym: Electron transfer flavoprotein
Synonym: Electron transfer flavoprotein (substance)
Synonym: Electron-Transferring Flavoprotein
Synonym: Electron-Transferring Flavoproteins [Chemical/Ingredient]
Synonym: Flavoprotein, ET
Tree Number: T6.10.3.23.12
database_cross_reference: MSH:D044927
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169058
database_cross_reference: RCD:X80HP
database_cross_reference: SNOMEDCT_US:259373009

Oxidoreductases
type: Class
subclass of: Enzymes
MCID: MC00009568
PMOID: PMO:00020074
Subclass_of: Enzymes
Synonym: 661-675 OXIDOREDUCTASES
Synonym: Dehydrogenase
Synonym: Dehydrogenase (biological function)
Synonym: Dehydrogenase (biological function) (substance)
Synonym: Dehydrogenase (substance)
Synonym: Dehydrogenase -Retired-
Synonym: Dehydrogenases
Synonym: EC 1
Synonym: OXIDOREDUCTASES
Synonym: Oxidoreductase
Tree Number: T6.7.4.9
database_cross_reference: AOD:0000018403
database_cross_reference: CHV:0000009147
database_cross_reference: CSP:2166-4991
database_cross_reference: LCH:U003423
database_cross_reference: LCH_NW:sh85036492
database_cross_reference: LCH_NW:sh85096317
database_cross_reference: LNC:LP21218-0
database_cross_reference: MSH:D010088
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16946
database_cross_reference: NDFRT:N0000008209
database_cross_reference: PSY:13290
database_cross_reference: RCD:Xa9tb
database_cross_reference: RCD:Xa9tg
database_cross_reference: RCD:Xa9wl
database_cross_reference: SNM:F-23060
database_cross_reference: SNMI:F-66100
database_cross_reference: SNOMEDCT_US:124225003
database_cross_reference: SNOMEDCT_US:124235009
database_cross_reference: SNOMEDCT_US:129919009
database_cross_reference: SNOMEDCT_US:129925008
database_cross_reference: SNOMEDCT_US:68101005

Alcohol Oxidoreductases
type: Class
subclass of: Oxidoreductases
MCID: MC00000513
PMOID: PMO:00020075
Subclass_of: Oxidoreductases
Synonym: Alcohol Oxidoreductases [Chemical/Ingredient]
Synonym: Carbonyl Reductases
Synonym: Ketone Reductases
Synonym: Oxidoreductases, Alcohol
Synonym: Reductases, Carbonyl
Synonym: Reductases, Ketone
Synonym: alcohol oxidoreductase
Synonym: alcohol oxidoreductases
Tree Number: T6.7.4.9.1
database_cross_reference: AOD:0000018404
database_cross_reference: CSP:4000-0110
database_cross_reference: MSH:D000429
database_cross_reference: NDFRT:N0000167946

Aspartokinase Homoserine Dehydrogenase
type: Class
subclass of: PMO:00020867
MCID: MC00001306
PMOID: PMO:00020124
Subclass_of: Multifunctional Enzymes
Synonym: Aspartokinase Homoserine Dehydrogenase [Chemical/Ingredient]
Synonym: Aspartokinase-Homoserine Dehydrogenase, Bifunctional
Synonym: Bifunctional Aspartokinase Homoserine Dehydrogenase
Synonym: Bifunctional Aspartokinase-Homoserine Dehydrogenase
Synonym: Dehydrogenase, Aspartokinase Homoserine
Synonym: Dehydrogenase, Bifunctional Aspartokinase-Homoserine
Synonym: Homoserine Dehydrogenase, Aspartokinase
Tree Number: T6.7.4.18.3
database_cross_reference: MSH:D001225
database_cross_reference: NDFRT:N0000168254

Oxidoreductases Acting on CH-NH Group Donors
type: Class
subclass of: Oxidoreductases
MCID: MC00545903
PMOID: PMO:00020143
Subclass_of: Oxidoreductases
Synonym: Amine Oxidoreductases, Secondary
Synonym: Amine Oxidoreductases, Secondary Amine
Synonym: Oxidoreductases Acting on CH NH Group Donors
Synonym: Oxidoreductases Acting on CH-NH Group Donors [Chemical/Ingredient]
Synonym: Oxidoreductases, Secondary Amine
Synonym: Secondary Amine Oxidoreductases
Tree Number: T6.7.4.9.2
database_cross_reference: MSH:D000587
database_cross_reference: NDFRT:N0000167876

Sarcosine Oxidase
type: Class
subclass of: PMO:00022858
MCID: MC00037401
PMOID: PMO:00020152
Subclass_of: Flavoproteins
Synonym: Acid Oxidase, L-Pipecolic
Synonym: L Pipecolic Acid Oxidase
Synonym: L-Pipecolic Acid Oxidase
Synonym: Oxidase, L-Pipecolic Acid
Synonym: Oxidase, Sarcosine
Synonym: Sarcosine Oxidase [Chemical/Ingredient]
Synonym: Sarcosine oxidase
Synonym: Sarcosine oxidase (substance)
Synonym: Sarcosine-Oxygen Oxidoreductase (Demethylating)
Tree Number: T6.10.3.23.16
database_cross_reference: MSH:D050879
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169064
database_cross_reference: SNMI:F-66E10
database_cross_reference: SNOMEDCT_US:86613002

Methylenetetrahydrofolate Reductase (NADPH2)
type: Class
subclass of: PMO:00022858
MCID: MC00031369
PMOID: PMO:00020164
Subclass_of: Flavoproteins
Synonym: 5,10-Methylenetetrahydrofolate Reductase (NADPH)
Synonym: 5-methyltetrahydrofolate:NADP oxidoreductase
Synonym: EC 1.5.1.20
Synonym: MTHFR
Synonym: Methylene Tetrahydrofolate Reductase
Synonym: Methylene tetrahydrofol reduc
Synonym: Methylene tetrahydrofolate reductase
Synonym: Methylene-THF Reductase (NADPH)
Synonym: Methylenetetrahydrofolate Reductase
Synonym: Methylenetetrahydrofolate Reductase (NADPH)
Tree Number: T6.10.3.23.9
database_cross_reference: CHV:0000014396
database_cross_reference: CSP:4000-0252
database_cross_reference: LCH_NW:sh2005003812
database_cross_reference: MSH:D042965
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17311
database_cross_reference: NDFRT:N0000169060
database_cross_reference: RCD:X80Ha
database_cross_reference: SNMI:F-66E00
database_cross_reference: SNOMEDCT_US:79514008

Ascorbate Oxidase
type: Class
subclass of: Oxidoreductases
MCID: MC00001289
PMOID: PMO:00020167
Subclass_of: Oxidoreductases
Synonym: Ascorbase
Synonym: Ascorbate Oxidase [Chemical/Ingredient]
Synonym: Ascorbino Dehydrogenase
Synonym: Dehydrogenase, Ascorbino
Synonym: L Ascorbate Oxidase
Synonym: L ascorbate oxidase
Synonym: L-Ascorbate Oxidase
Synonym: L-Ascorbate oxidase
Synonym: L-Ascorbate oxidase (substance)
Synonym: L-Ascorbate:oxygen oxidoreductase
Tree Number: T6.7.4.9.3
database_cross_reference: CHV:0000001504
database_cross_reference: CSP:2168-9340
database_cross_reference: MSH:D001204
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167795
database_cross_reference: SNMI:F-67098
database_cross_reference: SNOMEDCT_US:84547006

Ceruloplasmin
type: Class
subclass of: Oxidoreductases
subclass of: PMO:00022152
subclass of: PMO:00023559
MCID: MC00002542
PMOID: PMO:00020168
Subclass_of: Carrier Proteins
Subclass_of: Metalloproteins
Subclass_of: Oxidoreductases
Synonym: CP - Caeruloplasmin
Synonym: CP - Ceruloplasmin
Synonym: Caeruloplasmin
Synonym: Caeruloplasmin -RETIRED-
Synonym: Ceruloplasmin (substance)
Synonym: Ceruloplasmin -RETIRED-
Synonym: Ceruloplasmin Ferroxidase
Synonym: Ceruloplasmin Oxidase
Synonym: Ceruloplasmin [Chemical/Ingredient]
Synonym: Copper oxidase
Tree Number: T6.10.3.12.9
Tree Number: T6.10.3.33.2
Tree Number: T6.7.4.9.4
database_cross_reference: CHV:0000002686
database_cross_reference: CSP:1852-2364
database_cross_reference: LCH:U000912
database_cross_reference: LCH_NW:sh85022174
database_cross_reference: LNC:LP15479-6
database_cross_reference: LNC:MTHU009242
database_cross_reference: MSH:D002570
database_cross_reference: MTH:U001798
database_cross_reference: NCI:C104139
database_cross_reference: NDFRT:N0000169559
database_cross_reference: RCD:X80PK
database_cross_reference: RCDAE:X80PK
database_cross_reference: SNM:F-12460
database_cross_reference: SNMI:F-674F8
database_cross_reference: SNOMEDCT_US:123066001
database_cross_reference: SNOMEDCT_US:76269006

Hydrogenase
type: Class
subclass of: Oxidoreductases
MCID: MC00006471
PMOID: PMO:00020169
Subclass_of: Oxidoreductases
Synonym: Ferredoxin Hydrogenase
Synonym: Ferredoxin:H+ oxidoreductase
Synonym: H2 Oxidizing Hydrogenase
Synonym: H2-Oxidizing Hydrogenase
Synonym: Hydrogenase (substance)
Synonym: Hydrogenase [Chemical/Ingredient]
Synonym: Hydrogenase, Ferredoxin
Synonym: Hydrogenase, H2-Oxidizing
Synonym: Hydrogenlyase
Synonym: hydrogenase
Tree Number: T6.7.4.9.6
database_cross_reference: CHV:0000006359
database_cross_reference: CSP:2174-6516
database_cross_reference: LCH:U002281
database_cross_reference: LCH_NW:sh85063435
database_cross_reference: MSH:D006864
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167945
database_cross_reference: SNMI:F-67550
database_cross_reference: SNOMEDCT_US:42722009

Luciferases
type: Class
subclass of: Oxidoreductases
subclass of: PMO:00023057
MCID: MC00007691
PMOID: PMO:00020170
Subclass_of: Luminescent Proteins
Subclass_of: Oxidoreductases
Synonym: Immunologic, Luciferase
Synonym: Luciferase
Synonym: Luciferases [Chemical/Ingredient]
Synonym: luciferase
Tree Number: T6.10.3.31.2
Tree Number: T6.7.4.9.7
database_cross_reference: CHV:0000007556
database_cross_reference: CSP:2112-6038
database_cross_reference: LCH_NW:sh2007001349
database_cross_reference: MSH:D008156
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16802
database_cross_reference: NDFRT:N0000169112

Luciferases, Bacterial
type: Class
subclass of: PMO:00021903
MCID: MC00516777
PMOID: PMO:00020173
Subclass_of: Bacterial Proteins
Synonym: Alkanal Monooxygenase (FMN-Linked)
Synonym: Bacterial Luciferases
Synonym: Luciferases, Bacterial [Chemical/Ingredient]
Tree Number: T6.10.3.10.25
database_cross_reference: MSH:D049453
database_cross_reference: NDFRT:N0000169114

NADH, NADPH Oxidoreductases
type: Class
subclass of: Oxidoreductases
MCID: MC00008626
PMOID: PMO:00020174
Subclass_of: Oxidoreductases
Synonym: NAD(P)H oxidoreductase
Synonym: NADH, NADPH Oxidoreductases [Chemical/Ingredient]
Synonym: NADPH Oxidoreductases NADH
Synonym: NADPH oxidoreductase
Synonym: NADPH oxidoreductases
Synonym: Oxidoreductases NADH, NADPH
Synonym: Oxidoreductases, NADH, NADPH
Tree Number: T6.7.4.9.8
database_cross_reference: AOD:0000018480
database_cross_reference: CSP:4000-0263
database_cross_reference: MSH:D009247
database_cross_reference: NDFRT:N0000167806

Cytochrome-B(5) Reductase
type: Class
subclass of: PMO:00022858
MCID: MC00024060
PMOID: PMO:00020177
Subclass_of: Flavoproteins
Synonym: B5 Reductase, NADH-Cytochrome
Synonym: CYTOCHROME B 05 REDUCTASE
Synonym: CYTOCHROME B5 REDUCTASE
Synonym: Cytochrome B5 reductase
Synonym: Cytochrome-B(5) Reductase [Chemical/Ingredient]
Synonym: Cytochrome-b5 reductase
Synonym: Cytochrome-b5 reductase (substance)
Synonym: Cytochrome-b>5< reductase
Tree Number: T6.10.3.23.10
database_cross_reference: CSP:2169-3086
database_cross_reference: LNC:LP15524-9
database_cross_reference: LNC:MTHU010267
database_cross_reference: MSH:D042966
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169061
database_cross_reference: SNMI:F-66E80
database_cross_reference: SNOMEDCT_US:90867003

NADP Transhydrogenase, B-Specific
type: Class
subclass of: PMO:00021903
MCID: MC00831129
PMOID: PMO:00020180
Subclass_of: Bacterial Proteins
Synonym: NADP Transhydrogenase, B Specific
Synonym: NADP Transhydrogenase, B-Specific [Chemical/Ingredient]
Synonym: Pyridine Nucleotide Transhydrogenase, B Specific
Synonym: Pyridine Nucleotide Transhydrogenase, B-Specific
Tree Number: T6.10.3.10.30
database_cross_reference: MSH:D061086
database_cross_reference: NDFRT:N0000183543

NADPH Oxidases
type: Class
subclass of: PMO:00022858
subclass of: PMO:00023060
PMOID: PMO:00020186
Subclass_of: Flavoproteins
Subclass_of: Membrane Proteins
Tree Number: T6.10.3.23.6
Tree Number: T6.10.3.32.19

NADH Dehydrogenase
type: Class
subclass of: PMO:00022858
MCID: MC00008624
PMOID: PMO:00020192
Subclass_of: Flavoproteins
Synonym: Cytochrome c Reductase
Synonym: Cytochrome c reductase
Synonym: Dehydrogenase, NADH
Synonym: Diaphorase (NADH Dehydrogenase)
Synonym: NADH (Acceptor) Oxidoreductase
Synonym: NADH Cytochrome c Oxidoreductase
Synonym: NADH Cytochrome c Reductase
Synonym: NADH Dehydrogenase [Chemical/Ingredient]
Synonym: NADH cytochrome C reductase
Synonym: NADH dehydrogenase
Tree Number: T6.10.3.23.4
database_cross_reference: CSP:2180-6402
database_cross_reference: CSP:2180-7339
database_cross_reference: LNC:LP15742-7
database_cross_reference: LNC:LP33249-1
database_cross_reference: LNC:MTHU012803
database_cross_reference: LNC:MTHU016502
database_cross_reference: MSH:D009245
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169644
database_cross_reference: SNMI:F-66F48
database_cross_reference: SNOMEDCT_US:51824007

Apoptosis Inducing Factor
type: Class
subclass of: PMO:00022858
MCID: MC00263073
PMOID: PMO:00020193
Subclass_of: Flavoproteins
Synonym: AIF Apoptosis Regulatory Protein
Synonym: Apoptosis Inducing Factor [Chemical/Ingredient]
Synonym: Apoptosis-Inducing Factor
Synonym: Apoptosis-Inducing Factor, Mitochondrial
Synonym: Mitochondrial Apoptosis Inducing Factor
Synonym: Mitochondrial Apoptosis-Inducing Factor
Tree Number: T6.10.3.23.20
database_cross_reference: MSH:D051033
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170493

Nitrogenase
type: Class
subclass of: Oxidoreductases
MCID: MC00008943
PMOID: PMO:00020194
Subclass_of: Oxidoreductases
Synonym: Dinitrogenase
Synonym: Nitrogenase (substance)
Synonym: Nitrogenase [Chemical/Ingredient]
Synonym: Reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing)
Synonym: nitrogenase
Tree Number: T6.7.4.9.9
database_cross_reference: CSP:4001-0093
database_cross_reference: LCH_NW:sh94006031
database_cross_reference: MSH:D009591
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167793
database_cross_reference: SNMI:F-67548
database_cross_reference: SNOMEDCT_US:83705001

Nitroreductases
type: Class
subclass of: Oxidoreductases
MCID: MC00008956
PMOID: PMO:00020197
Subclass_of: Oxidoreductases
Synonym: Nitroreductases [Chemical/Ingredient]
Synonym: Oxidoreductases Acting on other Nitrogenous Compounds as Donors
Tree Number: T6.7.4.9.10
database_cross_reference: MSH:D009601
database_cross_reference: NDFRT:N0000167935

Nitrate Reductase (NADH)
type: Class
subclass of: PMO:00022858
MCID: MC00033267
PMOID: PMO:00020199
Subclass_of: Flavoproteins
Synonym: Assimilatory Nitrate Reductase, NADH Dependent
Synonym: Assimilatory Nitrate Reductase, NADH-Dependent
Synonym: Assimilatory nitrate reductase
Synonym: NADH Dependent Nitrate Reductase
Synonym: NADH Nitrate Reductase
Synonym: NADH-Dependent Nitrate Reductase
Synonym: NADH-Nitrate Reductase
Synonym: Nitrate Reductase (NADH) [Chemical/Ingredient]
Synonym: Nitrate Reductase (NADH)2
Synonym: Nitrate Reductase, NADH-Dependent
Tree Number: T6.10.3.23.17
database_cross_reference: CSP:2181-6704
database_cross_reference: MSH:D050895
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169057
database_cross_reference: SNMI:F-66ED8
database_cross_reference: SNOMEDCT_US:130214006
database_cross_reference: SNOMEDCT_US:3737005

Nitrate Reductase (NAD(P)H)
type: Class
subclass of: PMO:00022858
MCID: MC00047791
PMOID: PMO:00020200
Subclass_of: Flavoproteins
Synonym: Assimilatory NAD(P)H Nitrate Reductase
Synonym: Bi-Specific NAD(P)H Nitrate Reductase
Synonym: NAD(P)H Bispecific Nitrate Reductase
Synonym: NAD(P)H Nitrate Reductase
Synonym: NAD(P)H-Nitrate Reductase
Synonym: Nitrate Reductase (NAD(P)H) [Chemical/Ingredient]
Synonym: Nitrate Reductase (Reduced Nicotinamide Adenine Dinucleotide (Phosphate))
Synonym: Nitrate Reductase NAD(P)H
Synonym: Nitrate reductase (NAD(P)H)
Synonym: Nitrate reductase [NAD(P)H]
Tree Number: T6.10.3.23.18
database_cross_reference: MSH:D050896
database_cross_reference: NDFRT:N0000169646
database_cross_reference: SNMI:F-66EE0
database_cross_reference: SNOMEDCT_US:8830003

Nitrate Reductase (NADPH)
type: Class
subclass of: PMO:00022858
MCID: MC00033268
PMOID: PMO:00020201
Subclass_of: Flavoproteins
Synonym: Assimilatory NADPH Nitrate Reductase
Synonym: Assimilatory NADPH-Nitrate Reductase
Synonym: Assimilatory Nitrate Reductase, NADPH Dependent
Synonym: Assimilatory Nitrate Reductase, NADPH-Dependent
Synonym: Assimilatory Reduced Nicotinamide Adenine Dinucleotide Phosphate Nitrate Reductase
Synonym: Assimilatory Reduced Nicotinamide Adenine Dinucleotide Phosphate-Nitrate Reductase
Synonym: NADPH Nitrate Reductase
Synonym: NADPH-Nitrate Reductase
Synonym: NADPH-Nitrate Reductase, Assimilatory
Synonym: NADPH:Nitrate Reductase
Tree Number: T6.10.3.23.19
database_cross_reference: MSH:D050897
database_cross_reference: NDFRT:N0000169643
database_cross_reference: SNMI:F-66EE8
database_cross_reference: SNOMEDCT_US:36690004

Oxidoreductases, O-Demethylating
type: Class
subclass of: Oxidoreductases
MCID: MC00009570
PMOID: PMO:00020207
Subclass_of: Oxidoreductases
Synonym: DEMETHYLASES O
Synonym: Demethylating Oxidoreductases, O
Synonym: O Demethylases
Synonym: O Demethylating Oxidoreductases
Synonym: O-Demethylases
Synonym: O-Demethylating Oxidoreductases
Synonym: O-demethylating oxidoreductase
Synonym: OXIDOREDUCTASES DEMETHYLATING O
Synonym: Oxidoreductases, O Demethylating
Synonym: Oxidoreductases, O-Demethylating [Chemical/Ingredient]
Tree Number: T6.7.4.9.11
database_cross_reference: AOD:0000018488
database_cross_reference: MSH:D010090
database_cross_reference: NDFRT:N0000167941

Oxygenases
type: Class
subclass of: Oxidoreductases
MCID: MC00009584
PMOID: PMO:00020209
Subclass_of: Oxidoreductases
Synonym: Oxygenase
Synonym: Oxygenase (substance)
Synonym: Oxygenases [Chemical/Ingredient]
Synonym: oxygenase
Tree Number: T6.7.4.9.12
database_cross_reference: AOD:0000018491
database_cross_reference: CSP:2192-0005
database_cross_reference: LCH:U003426
database_cross_reference: LCH_NW:sh85096341
database_cross_reference: MSH:D010105
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C28459
database_cross_reference: NDFRT:N0000167843
database_cross_reference: SNOMEDCT_US:129922006

AlkB Enzymes
type: Class
subclass of: PMO:00020864
MCID: MC01054831
PMOID: PMO:00020235
Subclass_of: DNA Repair Enzymes
Synonym: AlkB Enzymes [Chemical/Ingredient]
Synonym: AlkB Homologs
Synonym: Alkylated DNA Repair Protein AlkB Homologs
Synonym: Alkylation Repair Homolog Proteins
Synonym: Alkylation Repair Homologs
Synonym: Enzymes, AlkB
Tree Number: T6.7.4.16.2
database_cross_reference: MSH:D000071496
database_cross_reference: NDFRT:N0000193141

Peroxidases
type: Class
subclass of: Oxidoreductases
MCID: MC00009950
PMOID: PMO:00020256
Subclass_of: Oxidoreductases
Synonym: Peroxidase
Synonym: Peroxidase (substance)
Synonym: Peroxidases [Chemical/Ingredient]
Synonym: peroxidase
Synonym: peroxidases
Tree Number: T6.7.4.9.13
database_cross_reference: AOD:0000018494
database_cross_reference: CHV:0000009536
database_cross_reference: CSP:2250-2222
database_cross_reference: MSH:D010544
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008022
database_cross_reference: RCD:Xa9ty
database_cross_reference: SNOMEDCT_US:59027002

Peroxiredoxin III
type: Class
subclass of: PMO:00023874
MCID: MC00378196
PMOID: PMO:00020268
Subclass_of: Mitochondrial Proteins
Synonym: Mitochondrial Thioredoxin Dependent Antioxidant Protein SP 22
Synonym: Mitochondrial Thioredoxin-Dependent Antioxidant Protein SP-22
Synonym: PRDX3 Peroxidase
Synonym: PRDX3 peroxidase
Synonym: Peroxiredoxin 3
Synonym: Peroxiredoxin III [Chemical/Ingredient]
Synonym: Thioredoxin Dependent Peroxide Reductase, Mitochondrial
Synonym: Thioredoxin-Dependent Peroxide Reductase, Mitochondrial
Tree Number: T6.10.3.74.9
database_cross_reference: MSH:D061105
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000183498

Ribonucleotide Reductases
type: Class
subclass of: Oxidoreductases
MCID: MC00011389
PMOID: PMO:00020270
Subclass_of: Oxidoreductases
Synonym: EC 1.17.4.-
Synonym: Reductase, Ribonucleotide
Synonym: Reductases, Ribonucleotide
Synonym: Ribonucleotide Reductase
Synonym: Ribonucleotide Reductases [Chemical/Ingredient]
Synonym: ribonucleotide reductase
Synonym: ribonucleotide reductases
Tree Number: T6.7.4.9.14
database_cross_reference: AOD:0000018437
database_cross_reference: CHV:0000010883
database_cross_reference: CSP:4001-0115
database_cross_reference: MSH:D012264
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17101
database_cross_reference: NDFRT:N0000167943

Superoxide Dismutase
type: Class
subclass of: Oxidoreductases
MCID: MC00012436
PMOID: PMO:00020272
Subclass_of: Oxidoreductases
Synonym: Dismutase, Superoxide
Synonym: E.C. 1.15.1.1
Synonym: Erythrocuprein
Synonym: Hemocuprein
Synonym: SOD
Synonym: SUPEROXIDE DISMUTASE
Synonym: Superoxide Dismutase (SOD)
Synonym: Superoxide Dismutase [Chemical/Ingredient]
Synonym: Superoxide dismutase
Synonym: Superoxide dismutase (substance)
Tree Number: T6.7.4.9.16
database_cross_reference: AOD:0000018508
database_cross_reference: CHV:0000011895
database_cross_reference: CSP:2185-7910
database_cross_reference: LCH:U004531
database_cross_reference: LCH_NW:sh85130641
database_cross_reference: LNC:LP15877-1
database_cross_reference: LNC:MTHU014002
database_cross_reference: MEDCIN:199524
database_cross_reference: MSH:D013482
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17172
database_cross_reference: NCI_DCP:05090
database_cross_reference: NDDF:000941
database_cross_reference: NDFRT:N0000167805
database_cross_reference: NDFRT:N0000182833
database_cross_reference: RXNORM:10245
database_cross_reference: SNMI:F-674E8
database_cross_reference: SNOMEDCT_US:27562008
database_cross_reference: VANDF:4030847

Urate Oxidase
type: Class
subclass of: Oxidoreductases
MCID: MC00013337
PMOID: PMO:00020274
Subclass_of: Oxidoreductases
Synonym: Oxidase, Urate
Synonym: URATE OXIDASE
Synonym: Urate Oxidase [Chemical/Ingredient]
Synonym: Urate oxidase
Synonym: Urate oxidase (substance)
Synonym: Urate:oxygen oxidoreductase
Synonym: Uricase
Synonym: urate oxidase
Synonym: uricase
Tree Number: T6.7.4.9.17
database_cross_reference: ATC:M04AX01
database_cross_reference: CHV:0000012749
database_cross_reference: CSP:4000-0252
database_cross_reference: MSH:D014503
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:005927
database_cross_reference: NDFRT:N0000011471
database_cross_reference: PDQ:CDR0000299001
database_cross_reference: SNM:F-23760
database_cross_reference: SNMI:F-66F90
database_cross_reference: SNOMEDCT_US:84131000

Laccase
type: Class
subclass of: Oxidoreductases
MCID: MC00029985
PMOID: PMO:00020275
Subclass_of: Oxidoreductases
Synonym: Laccase (substance)
Synonym: Laccase [Chemical/Ingredient]
Synonym: Oxidase, Urishiol
Synonym: Oxidase, p-Diphenol
Synonym: Urishiol Oxidase
Synonym: Urishiol oxidase
Synonym: laccase
Synonym: p Diphenol Oxidase
Synonym: p-Diphenol Oxidase
Tree Number: T6.7.4.9.18
database_cross_reference: CHV:0000014263
database_cross_reference: CSP:4000-0252
database_cross_reference: LCH_NW:sh85073800
database_cross_reference: MSH:D042845
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167919
database_cross_reference: SNMI:F-67090
database_cross_reference: SNOMEDCT_US:24537003

Oxidoreductases Acting on CH-CH Group Donors
type: Class
subclass of: Oxidoreductases
MCID: MC00421648
PMOID: PMO:00020276
Subclass_of: Oxidoreductases
Synonym: Oxidoreductases Acting on CH CH Group Donors
Synonym: Oxidoreductases Acting on CH-CH Group Donors [Chemical/Ingredient]
Tree Number: T6.7.4.9.19
database_cross_reference: MSH:D044925
database_cross_reference: NDFRT:N0000167921

Acyl-CoA Oxidase
type: Class
subclass of: PMO:00022858
MCID: MC00019238
PMOID: PMO:00020284
Subclass_of: Flavoproteins
Synonym: Acyl CoA Oxidase
Synonym: Acyl Coenzyme A Oxidase
Synonym: Acyl-CoA Oxidase [Chemical/Ingredient]
Synonym: Acyl-CoA Oxidase, Fatty
Synonym: Acyl-CoA oxidase
Synonym: Acyl-CoA oxidase (substance)
Synonym: Acyl-coenzyme A oxidase
Synonym: Acyl-coenzyme A oxidase (substance)
Synonym: Fatty Acid Acyl CoA Oxidase
Synonym: Fatty Acid Acyl-CoA Oxidase
Tree Number: T6.10.3.23.7
database_cross_reference: MSH:D042962
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169056
database_cross_reference: SNOMEDCT_US:130113008

Acyl-CoA Dehydrogenase
type: Class
subclass of: PMO:00022858
MCID: MC00019236
PMOID: PMO:00020285
Subclass_of: Flavoproteins
Synonym: Acyl CoA Dehydrogenase
Synonym: Acyl CoA dehydrogenase
Synonym: Acyl coenzyme A Dehydrogenase
Synonym: Acyl-CoA Dehydrogenase [Chemical/Ingredient]
Synonym: Acyl-CoA Dehydrogenase, Medium-Chain
Synonym: Acyl-coenzyme A Dehydrogenase
Synonym: CoA Dehydrogenase, Fatty-acyl
Synonym: Dehydrogenase, Acyl-CoA
Synonym: Dehydrogenase, Acyl-coenzyme A
Synonym: Dehydrogenase, Fatty-acyl CoA
Tree Number: T6.10.3.23.8
database_cross_reference: CHV:0000013430
database_cross_reference: LNC:LP15319-4
database_cross_reference: LNC:LP173714-9
database_cross_reference: LNC:MTHU007350
database_cross_reference: LNC:MTHU047882
database_cross_reference: MSH:D042964
database_cross_reference: MTH:U002482
database_cross_reference: NDFRT:N0000169071
database_cross_reference: RCD:X80Kf
database_cross_reference: SNOMEDCT_US:259480007

Butyryl-CoA Dehydrogenase
type: Class
subclass of: PMO:00022858
MCID: MC00022066
PMOID: PMO:00020286
Subclass_of: Flavoproteins
Synonym: Acyl-CoA Dehydrogenase, Short-Chain
Synonym: Butyryl CoA Dehydrogenase
Synonym: Butyryl Coenzyme A Dehydrogenase
Synonym: Butyryl Dehydrogenase
Synonym: Butyryl dehydrogenase
Synonym: Butyryl-CoA Dehydrogenase [Chemical/Ingredient]
Synonym: Butyryl-CoA dehydrogenase
Synonym: Butyryl-CoA dehydrogenase (substance)
Synonym: Butyryl-Coenzyme A Dehydrogenase
Synonym: Dehydrogenase, Butyryl
Tree Number: T6.10.3.23.11
database_cross_reference: LNC:LP201755-8
database_cross_reference: MSH:D044926
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169070
database_cross_reference: RCD:X80Kj
database_cross_reference: SNMI:F-66BF0
database_cross_reference: SNOMEDCT_US:259483009
database_cross_reference: SNOMEDCT_US:26164009

Acyl-CoA Dehydrogenase, Long-Chain
type: Class
subclass of: PMO:00022858
MCID: MC00030451
PMOID: PMO:00020287
Subclass_of: Flavoproteins
Synonym: Acyl CoA Dehydrogenase, Long Chain
Synonym: Acyl-CoA Dehydrogenase, Long-Chain [Chemical/Ingredient]
Synonym: Acyl-CoA Dehydrogenase, Very-Long-Chain
Synonym: Dehydrogenase, Long-Chain Acyl-CoA
Synonym: Dehydrogenase, Long-Chain-Acyl-CoA
Synonym: Dehydrogenase, Long-Chain-Acyl-Coenzyme A
Synonym: Dehydrogenase, Very-Long-Chain Acyl-CoA
Synonym: Long Chain Acyl CoA Dehydrogenase
Synonym: Long Chain Acyl Coenzyme A Dehydrogenase
Synonym: Long ch acyl-CoA dehydrogenase
Tree Number: T6.10.3.23.13
database_cross_reference: CHV:0000014314
database_cross_reference: MSH:D044942
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169066
database_cross_reference: RCD:X80Kd
database_cross_reference: SNOMEDCT_US:130158002
database_cross_reference: SNOMEDCT_US:259478001

Protoporphyrinogen Oxidase
type: Class
subclass of: PMO:00023060
MCID: MC00036185
PMOID: PMO:00020292
Subclass_of: Membrane Proteins
Synonym: Dehydrogenase, Protoporphyrinogen
Synonym: Oxidase, Protoporphyrinogen
Synonym: Oxidase, Protoporphyrinogen IX
Synonym: Protoporphyrinogen Dehydrogenase
Synonym: Protoporphyrinogen IX Oxidase
Synonym: Protoporphyrinogen Oxidase [Chemical/Ingredient]
Synonym: Protoporphyrinogen oxidase
Synonym: Protoporphyrinogen oxidase (substance)
Synonym: Protoporphyrinogenase
Synonym: Protox
Tree Number: T6.10.3.32.35
database_cross_reference: MSH:D050768
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168695
database_cross_reference: RCD:X80LI
database_cross_reference: SNMI:F-66BC8
database_cross_reference: SNOMEDCT_US:81655005

5,10-Methylenetetrahydrofolate Reductase (FADH2)
type: Class
subclass of: Oxidoreductases
MCID: MC00017857
PMOID: PMO:00020295
Subclass_of: Oxidoreductases
Synonym: 5,10-Methylenetetrahydrofolate Reductase (FADH)
Synonym: 5,10-Methylenetetrahydrofolate Reductase (FADH2) [Chemical/Ingredient]
Synonym: 5,10-Methylenetetrahydrofolate reductase
Synonym: 5,10-Methylenetetrahydrofolate reductase (FADH2)
Synonym: 5,10-Methylenetetrahydrofolate reductase (FADH2) (substance)
Synonym: 5,10-Methylenetetrahydrofolate reductase (FADH>2<)
Synonym: 5,10-Methylenetetrahydrofolate reductase (FADH>2<) (substance)
Synonym: 5,10-Methylenetetrahydrofolate reductase (reduced flavin adenine dinucleotide)
Tree Number: T6.7.4.9.20
database_cross_reference: LNC:LP15306-1
database_cross_reference: LNC:MTHU027231
database_cross_reference: MSH:D045103
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000167920
database_cross_reference: SNM:F-22440
database_cross_reference: SNMI:F-66FC8
database_cross_reference: SNOMEDCT_US:37662007

Oxidoreductases Acting on Aldehyde or Oxo Group Donors
type: Class
subclass of: Oxidoreductases
MCID: MC00541105
PMOID: PMO:00020296
Subclass_of: Oxidoreductases
Synonym: Oxidoreductases Acting on Aldehyde or Oxo Group Donors [Chemical/Ingredient]
Tree Number: T6.7.4.9.22
database_cross_reference: MSH:D050837
database_cross_reference: NDFRT:N0000167892

Aldehyde Dehydrogenase, Mitochondrial
type: Class
subclass of: PMO:00023874
MCID: MC00767424
PMOID: PMO:00020299
Subclass_of: Mitochondrial Proteins
Synonym: ALDH2 Protein
Synonym: Aldehyde Dehydrogenase Mitochondrial
Synonym: Aldehyde Dehydrogenase, Mitochondrial [Chemical/Ingredient]
Synonym: Dehydrogenase, Mitochondrial Aldehyde
Synonym: Mitochondrial Aldehyde Dehydrogenase
Tree Number: T6.10.3.74.1
database_cross_reference: MSH:D000071396
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000193022

Retinal Dehydrogenase
type: Class
subclass of: PMO:00022858
MCID: MC00036656
PMOID: PMO:00020314
Subclass_of: Flavoproteins
Synonym: Cytosolic Retinal Dehydrogenase
Synonym: Dehydrogenase, Cytosolic Retinal
Synonym: Dehydrogenase, Retinal
Synonym: Retinal Dehydrogenase [Chemical/Ingredient]
Synonym: Retinal Dehydrogenase, Cytosolic
Synonym: Retinal dehydrogenase
Synonym: Retinal dehydrogenase (substance)
Tree Number: T6.10.3.23.14
database_cross_reference: MSH:D050697
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169062
database_cross_reference: SNMI:F-669A0
database_cross_reference: SNOMEDCT_US:86878003

Oxidoreductases Acting on Sulfur Group Donors
type: Class
subclass of: Oxidoreductases
MCID: MC00541131
PMOID: PMO:00020324
Subclass_of: Oxidoreductases
Synonym: Oxidoreductases Acting on Sulfur Group Donors [Chemical/Ingredient]
Tree Number: T6.7.4.9.23
database_cross_reference: MSH:D050862
database_cross_reference: NDFRT:N0000167796

Thioredoxin-Disulfide Reductase
type: Class
subclass of: PMO:00022858
MCID: MC00012751
PMOID: PMO:00020328
Subclass_of: Flavoproteins
Synonym: NADP Thioredoxin Reductase
Synonym: NADP-Thioredoxin Reductase
Synonym: NADPH Thioredoxin Reductase
Synonym: NADPH-Thioredoxin Reductase
Synonym: Reductase, NADP-Thioredoxin
Synonym: Reductase, NADPH-Thioredoxin
Synonym: Reductase, Thioredoxin
Synonym: Reductase, Thioredoxin-Disulfide
Synonym: Thioredoxin Disulfide Reductase
Synonym: Thioredoxin Reductase
Tree Number: T6.10.3.23.5
database_cross_reference: CSP:4000-0263
database_cross_reference: MSH:D013880
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169063
database_cross_reference: SNMI:F-66EB0
database_cross_reference: SNOMEDCT_US:26233001

Oxidoreductases Acting on CH-NH2 Group Donors
type: Class
subclass of: Oxidoreductases
MCID: MC00541142
PMOID: PMO:00020337
Subclass_of: Oxidoreductases
Synonym: Amine Oxidoreductases, Primary
Synonym: Oxidoreductases Acting on CH NH2 Group Donors
Synonym: Oxidoreductases Acting on CH-NH2 Group Donors [Chemical/Ingredient]
Synonym: Oxidoreductases, Primary Amine
Synonym: Primary Amine Oxidoreductases
Tree Number: T6.7.4.9.24
database_cross_reference: MSH:D050891
database_cross_reference: NDFRT:N0000167821

Glutamate Synthase (NADH)
type: Class
subclass of: PMO:00022858
MCID: MC00113375
PMOID: PMO:00020350
Subclass_of: Flavoproteins
Synonym: Glutamate Synthase (NADH) [Chemical/Ingredient]
Synonym: Glutamate Synthase, NADH-Dependent
Synonym: Glutamate synthase (NADH)
Synonym: Glutamate synthase (NADH) (substance)
Synonym: Glutamate synthase (reduced nicotinamide adenine dinucleotide)
Synonym: Glutamate synthase (reduced nicotinamide adenine dinucleotide) (substance)
Synonym: L Glutamate Synthetase
Synonym: L-Glutamate Synthetase
Synonym: NADH Dependent Glutamate Synthase
Synonym: NADH GOGAT
Tree Number: T6.10.3.23.15
database_cross_reference: MSH:D050790
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169065
database_cross_reference: SNMI:F-66CA0
database_cross_reference: SNOMEDCT_US:53306006

Methionine Sulfoxide Reductases
type: Class
subclass of: Oxidoreductases
subclass of: PMO:00023915
MCID: MC00744191
PMOID: PMO:00020358
Subclass_of: Oxidoreductases
Subclass_of: Selenoproteins
Synonym: Methionine Sulfoxide Reductases [Chemical/Ingredient]
Synonym: Reductases, Methionine Sulfoxide
Synonym: Sulfoxide Reductases, Methionine
Tree Number: T6.10.3.89.2
Tree Number: T6.7.4.9.25
database_cross_reference: MSH:D051150
database_cross_reference: NDFRT:N0000180241

Arsenate Reductases
type: Class
subclass of: Oxidoreductases
MCID: MC00020558
PMOID: PMO:00020359
Subclass_of: Oxidoreductases
Synonym: Arsenate Reductase
Synonym: Arsenate Reductases [Chemical/Ingredient]
Synonym: Reductase, Arsenate
Synonym: Reductases, Arsenate
Synonym: arsenate reductase
Tree Number: T6.7.4.9.26
database_cross_reference: MSH:D053502
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000175178

Transferases
type: Class
subclass of: Enzymes
MCID: MC00012994
PMOID: PMO:00020360
Subclass_of: Enzymes
Synonym: 680-697 TRANSFERASES
Synonym: EC 2
Synonym: TRANSFERASES
Synonym: Transferase
Synonym: Transferase (substance)
Synonym: Transferase, NOS
Synonym: Transferases [Chemical/Ingredient]
Synonym: transferase
Synonym: transferases
Tree Number: T6.7.4.10
database_cross_reference: AOD:0000018512
database_cross_reference: CHV:0000012463
database_cross_reference: CSP:2958-9654
database_cross_reference: LCH:U004744
database_cross_reference: LCH_NW:sh85136913
database_cross_reference: MSH:D014166
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17210
database_cross_reference: NDFRT:N0000010375
database_cross_reference: PSY:53960
database_cross_reference: RCD:Xa9td
database_cross_reference: SNM:F-23350
database_cross_reference: SNMI:F-68000
database_cross_reference: SNOMEDCT_US:44121006

Acyltransferases
type: Class
subclass of: Transferases
MCID: MC00000332
PMOID: PMO:00020361
Subclass_of: Transferases
Synonym: Acetyltransferase
Synonym: Acyl transferase
Synonym: Acyltransferase
Synonym: Acyltransferases [Chemical/Ingredient]
Synonym: EC 2.3
Synonym: acyl transferase
Synonym: acyltransferase
Synonym: acyltransferases
Tree Number: T6.7.4.10.1
database_cross_reference: AOD:0000018513
database_cross_reference: CHV:0000000700
database_cross_reference: CSP:2954-0956
database_cross_reference: LCH:U000058
database_cross_reference: LCH_NW:sh87001830
database_cross_reference: MSH:D000217
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16259
database_cross_reference: NDFRT:N0000168124
database_cross_reference: RCD:XaDdm
database_cross_reference: SNM:F-20130
database_cross_reference: SNOMEDCT_US:124381006

p300-CBP Transcription Factors
type: Class
subclass of: PMO:00023737
MCID: MC00086341
PMOID: PMO:00020368
Subclass_of: Transcription Factors
Synonym: Coactivator, p300-CBP
Synonym: P A 300 CBP TRANSCRIPTION FACTORS
Synonym: Transcription Factors, p300-CBP
Synonym: p300 CBP Coactivator
Synonym: p300 CBP Protein
Synonym: p300 CBP Transcription Factors
Synonym: p300-CBP Coactivator
Synonym: p300-CBP Protein
Synonym: p300-CBP Transcription Factors [Chemical/Ingredient]
Tree Number: T6.10.3.55.45
database_cross_reference: MSH:D050880
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169894

CLOCK Proteins
type: Class
subclass of: PMO:00021865
MCID: MC00747817
PMOID: PMO:00020373
Subclass_of: Circadian Rhythm Signaling Peptides and Proteins
Synonym: CLOCK Protein
Synonym: CLOCK Proteins [Chemical/Ingredient]
Synonym: Circadian Locomotor Output Cycles Kaput Proteins
Tree Number: T6.10.2.38.1
Tree Number: T6.10.3.94.1
database_cross_reference: MSH:D056926
database_cross_reference: NDFRT:N0000180261

Factor XIIIa
type: Class
subclass of: PMO:00021955
MCID: MC00004952
PMOID: PMO:00020410
Subclass_of: Factor XIII
Synonym: Activated Factor XIII
Synonym: Activated factor XIII
Synonym: BLOOD COAG FACTOR XIII ACTIVATED
Synonym: Blood Coagulation Factor XIII, Activated
Synonym: Coagulation factor XIIIa
Synonym: Coagulation factor XIIIa (substance)
Synonym: Factor XIII, Activated
Synonym: Factor XIIIa [Chemical/Ingredient]
Synonym: Fibrinoligase
Synonym: XIIIa, Factor
Tree Number: T6.13.4.10.1
database_cross_reference: CSP:0125-3973
database_cross_reference: DRUGBANK:DB12909
database_cross_reference: MSH:D026122
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171479
database_cross_reference: SNMI:F-D7910
database_cross_reference: SNOMEDCT_US:9532005

Phosphotransferases
type: Class
subclass of: Transferases
MCID: MC00010164
PMOID: PMO:00020418
Subclass_of: Transferases
Synonym: EC 2.7
Synonym: Kinase
Synonym: Kinase (substance)
Synonym: Kinase Family
Synonym: Kinases
Synonym: Phosphokinase
Synonym: Phosphotransferase
Synonym: Phosphotransferase (substance)
Synonym: Phosphotransferases [Chemical/Ingredient]
Synonym: Transphosphorylases
Tree Number: T6.7.4.10.2
database_cross_reference: AOD:0000018543
database_cross_reference: CHV:0000009681
database_cross_reference: CSP:2305-4757
database_cross_reference: LCH:U003645
database_cross_reference: LCH_NW:sh85101133
database_cross_reference: MSH:D010770
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16984
database_cross_reference: NCI:C28597
database_cross_reference: NCI_NCI-GLOSS:CDR0000641114
database_cross_reference: NDFRT:N0000168200
database_cross_reference: PSY:27366
database_cross_reference: RCD:Xa9tY
database_cross_reference: SNOMEDCT_US:130094000
database_cross_reference: SNOMEDCT_US:304257007

DNA Polymerase gamma
type: Class
subclass of: PMO:00023874
MCID: MC00167875
PMOID: PMO:00020424
Subclass_of: Mitochondrial Proteins
Synonym: DNA polymerase gamma
Tree Number: T6.10.3.74.2
database_cross_reference: MSH:C104307
database_cross_reference: MTH:NOCODE

Rec A Recombinases
type: Class
subclass of: PMO:00020861
MCID: MC00011133
PMOID: PMO:00020438
Subclass_of: Recombinases
Synonym: RECA PROTEIN
Synonym: RECA RECOMBINASES
Synonym: Rec A Protein
Synonym: Rec A Recombinases [Chemical/Ingredient]
Synonym: RecA Protein
Synonym: Recombinases, Rec A
Synonym: recA protein
Tree Number: T6.7.4.15.1
database_cross_reference: CSP:4000-0311
database_cross_reference: MSH:D011938
database_cross_reference: NDFRT:N0000168281

RNA Polymerase Sigma 54
type: Class
subclass of: PMO:00021903
MCID: MC00042843
PMOID: PMO:00020447
Subclass_of: Bacterial Proteins
Synonym: RNA POLYMERASE SIGMA 054
Synonym: RNA Polymerase Sigma 54 [Chemical/Ingredient]
Synonym: RNA Polymerase SigmaN
Synonym: SigmaN, RNA Polymerase
Tree Number: T6.10.3.10.28
database_cross_reference: MSH:D051877
database_cross_reference: NDFRT:N0000169049

DNA, Catalytic
type: Class
subclass of: Enzymes
subclass of: PMO:00023949
MCID: MC00169700
PMOID: PMO:00020455
Subclass_of: DNA
Subclass_of: Enzymes
Synonym: Catalytic DNA
Synonym: DNA, Catalytic [Chemical/Ingredient]
Synonym: DNAzyme
Synonym: DNAzymes
Synonym: Deoxyribozyme
Synonym: Deoxyribozymes
Synonym: catalytic dna
Synonym: dnazyme
Synonym: dnazymes
Tree Number: T6.11.2.2.19
Tree Number: T6.7.4.14
database_cross_reference: CHV:0000038490
database_cross_reference: MSH:D021881
database_cross_reference: NDFRT:N0000170675

RNA, Ribosomal, Self-Splicing
type: Class
subclass of: PMO:00020858
MCID: MC00421622
PMOID: PMO:00020456
Subclass_of: RNA, Catalytic
Synonym: RNA, Ribosomal, Self-Splicing [Chemical/Ingredient]
Synonym: RNA, Self-Splicing Ribosomal
Synonym: Ribosomal RNA, Self-Splicing
Synonym: Self Splicing Ribosomal RNA
Synonym: Self-Splicing Ribosomal RNA
Tree Number: T6.7.4.12.2
database_cross_reference: MSH:D044563
database_cross_reference: NDFRT:N0000170730

Transposon Resolvases
type: Class
subclass of: PMO:00020861
MCID: MC00082209
PMOID: PMO:00020462
Subclass_of: Recombinases
Synonym: Resolvases, Transposon
Synonym: TnpR Protein
Synonym: Transposon Resolvases [Chemical/Ingredient]
Tree Number: T6.7.4.15.3
database_cross_reference: MSH:D045564
database_cross_reference: NDFRT:N0000168274

VDJ Recombinases
type: Class
subclass of: PMO:00020861
MCID: MC00421709
PMOID: PMO:00020463
Subclass_of: Recombinases
Synonym: Recombinase, V-D-J
Synonym: Recombinase, VDJ
Synonym: V D J Recombinase
Synonym: V(D)J Recombinase
Synonym: V-(D)-J Recombinase
Synonym: V-D-J Recombinase
Synonym: VDJ Recombinase
Synonym: VDJ Recombinases [Chemical/Ingredient]
Synonym: VDJ recombinases
Tree Number: T6.7.4.15.5
database_cross_reference: LCH_NW:sh2007009104
database_cross_reference: MSH:D045567
database_cross_reference: NDFRT:N0000168293

Creatine Kinase, Mitochondrial Form
type: Class
subclass of: PMO:00023874
MCID: MC00320691
PMOID: PMO:00020474
Subclass_of: Mitochondrial Proteins
Synonym: Creatine Kinase, Mitochondrial
Synonym: Creatine Kinase, Mitochondrial Form [Chemical/Ingredient]
Synonym: Kinase, Mitochondrial Creatine
Synonym: Mitochondrial Creatine Kinase
Tree Number: T6.10.3.74.7
database_cross_reference: MSH:D052281
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168299

Polynucleotide 5'-Hydroxyl-Kinase
type: Class
subclass of: PMO:00020864
MCID: MC00010443
PMOID: PMO:00020490
Subclass_of: DNA Repair Enzymes
Synonym: 5' Hydroxylpolynucleotide Kinase
Synonym: 5'-Hydroxyl Kinase, Polynucleotide
Synonym: 5'-Hydroxyl-Kinase, Polynucleotide
Synonym: 5'-Hydroxylkinase, DNA
Synonym: 5'-Hydroxylpolynucleotide Kinase
Synonym: ATP:5'-dephosphopolynucleotide 5'-phosphotransferase
Synonym: DNA 5' Hydroxylkinase
Synonym: DNA 5'-Hydroxylkinase
Synonym: DNA Kinase
Synonym: Hydroxykinase, Polynucleotide
Tree Number: T6.7.4.16.6
database_cross_reference: MSH:D011116
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168206
database_cross_reference: SNMI:F-69210
database_cross_reference: SNOMEDCT_US:69780008

Syk Kinase
type: Class
subclass of: PMO:00021684
MCID: MC00574121
PMOID: PMO:00020495
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Kinase, SYK Tyrosine
Synonym: Kinase, Spleen Tyrosine
Synonym: Kinase, Syk
Synonym: SYK Tyrosine Kinase
Synonym: Spleen Tyrosine Kinase
Synonym: Syk Kinase [Chemical/Ingredient]
Synonym: Syk kinase
Synonym: Tyrosine Kinase, SYK
Synonym: Tyrosine Kinase, Spleen
Tree Number: T6.10.2.33.4
Tree Number: T6.10.3.86.3
database_cross_reference: MSH:D000072377
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000193010

Proto-Oncogene Proteins c-fyn
type: Class
subclass of: PMO:00021684
MCID: MC00036166
PMOID: PMO:00020502
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Fyn Tyrosine Kinase
Synonym: Proteins c-fyn, Proto-Oncogene
Synonym: Proto Oncogene Protein c fyn
Synonym: Proto Oncogene Protein c syn
Synonym: Proto Oncogene Proteins c fyn
Synonym: Proto-Oncogene Protein c-fyn
Synonym: Proto-Oncogene Protein c-syn
Synonym: Proto-Oncogene Proteins c-fyn [Chemical/Ingredient]
Synonym: Proto-Oncogene Proteins, c-fyn
Synonym: Proto-Oncogene Proteins, fyn
Tree Number: T6.10.3.86.38
database_cross_reference: MSH:D051076
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169089

Receptor, ErbB-2
type: Class
subclass of: PMO:00024394
MCID: MC00033848
PMOID: PMO:00020551
Subclass_of: Biomarkers, Tumor
Synonym: Antigen, CD340
Synonym: Antigens, CD340
Synonym: C ERBB PROTEIN 002
Synonym: CD340 Antigen
Synonym: CD340 Antigens
Synonym: ERBB PROTO ONCOGENE PROTEIN 002
Synonym: ERBB RECEPTOR PROTEIN TYROSINE KINASE 002
Synonym: ErbB-2 Receptor
Synonym: HER 2 Proto Oncogene Protein
Synonym: HER PROTO ONCOGENE PROTEIN 002
Tree Number: T6.13.9.5.11
database_cross_reference: CHV:0000014541
database_cross_reference: LNC:LP28442-9
database_cross_reference: LNC:MTHU014669
database_cross_reference: MSH:D018719
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171361
database_cross_reference: SNMI:F-E3260
database_cross_reference: SNOMEDCT_US:44368005

Receptor, ErbB-3
type: Class
subclass of: PMO:00024394
MCID: MC00036158
PMOID: PMO:00020552
Subclass_of: Biomarkers, Tumor
Synonym: C ERBB PROTEIN 003
Synonym: ERBB PROTEIN 003
Synonym: ERBB3 Receptor Protein-Tyrosine Kinase
Synonym: ErbB-3 Receptor
Synonym: HER 3 Proto Oncogene Protein
Synonym: HER PROTO ONCOGENE PROTEIN 003
Synonym: HER-3 Proto-Oncogene Protein
Synonym: HER3
Synonym: PROTO ONCOGENE PROTEIN ERBB 003
Synonym: Protein c-ErbB-2, Proto-oncogene-like
Tree Number: T6.13.9.5.17
database_cross_reference: LNC:LP36218-3
database_cross_reference: MSH:D020893
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000171377

Receptor, ErbB-4
type: Class
subclass of: PMO:00024394
MCID: MC00069349
PMOID: PMO:00020553
Subclass_of: Biomarkers, Tumor
Synonym: ERBB4 Receptor Protein Tyrosine Kinase
Synonym: ErbB 4 Receptor
Synonym: ErbB-4 Receptor
Synonym: HER 4 Proto oncogene Protein
Synonym: HER-4 Proto-oncogene Protein
Synonym: HER-4, Proto-oncogene Protein
Synonym: Protein HER-4, Proto-oncogene
Synonym: Protein, HER-4 Proto-oncogene
Synonym: Proto oncogene Protein HER 4
Synonym: Proto-oncogene Protein HER-4
Tree Number: T6.13.9.5.20
database_cross_reference: MSH:D066247
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000191061

Mitogen-Activated Protein Kinase Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00065248
PMOID: PMO:00020554
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Kinase Kinase, Map
Synonym: Kinase Kinases, MAP
Synonym: Kinase, Map Kinase
Synonym: Kinases, MAP Kinase
Synonym: Kinases, MAPK
Synonym: MAP Kinase Kinase
Synonym: MAP Kinase Kinases
Synonym: MAP kinase kinase
Synonym: MAP2K
Synonym: MAPK Kinases
Tree Number: T6.10.2.33.26
Tree Number: T6.10.3.86.25
database_cross_reference: CSP:4006-0064
database_cross_reference: MSH:D020929
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C105947
database_cross_reference: NDFRT:N0000170600

Focal Adhesion Protein-Tyrosine Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00541610
PMOID: PMO:00020562
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Focal Adhesion Kinase
Synonym: Focal Adhesion Protein Tyrosine Kinase Family
Synonym: Focal Adhesion Protein Tyrosine Kinases
Synonym: Focal Adhesion Protein-Tyrosine Kinase
Synonym: Focal Adhesion Protein-Tyrosine Kinase Family
Synonym: Focal Adhesion Protein-Tyrosine Kinases [Chemical/Ingredient]
Synonym: Focal adhesion kinase
Tree Number: T6.10.2.33.35
Tree Number: T6.10.3.86.39
database_cross_reference: LCH_NW:sh2002000232
database_cross_reference: MSH:D051416
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170584

Focal Adhesion Kinase 1
type: Class
subclass of: PMO:00023655
MCID: MC00025942
PMOID: PMO:00020563
Subclass_of: Phosphoproteins
Synonym: Endogenous Substrate pp120
Synonym: FAK
Synonym: FOCAL ADHESION KINASE 001
Synonym: Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK
Synonym: Focal Adhesion Kinase 1 [Chemical/Ingredient]
Synonym: Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
Synonym: Protein Tyrosine Kinase 2
Synonym: endogenous substrate pp120
Synonym: fak
Synonym: focal adhesion kinase
Tree Number: T6.10.3.40.20
database_cross_reference: CHV:0000013940
database_cross_reference: CSP:4008-0039
database_cross_reference: MSH:D051417
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169255

ZAP-70 Protein-Tyrosine Kinase
type: Class
subclass of: PMO:00021684
MCID: MC00083117
PMOID: PMO:00020566
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: 70 kDa Zeta Associated Protein
Synonym: 70 kDa Zeta-Associated Protein
Synonym: Kinase, ZAP-70
Synonym: Protein-Tyrosine Kinase, ZAP-70
Synonym: Syk Related Tyrosine Kinase
Synonym: Syk-Related Tyrosine Kinase
Synonym: Tyrosine Kinase, Syk-Related
Synonym: ZAP 070 PROTEIN TYROSINE KINASE
Synonym: ZAP 70 Kinase
Synonym: ZAP 70 Protein
Tree Number: T6.10.3.86.42
database_cross_reference: LNC:LP40299-7
database_cross_reference: MSH:D051746
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000168240

Janus Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00183234
PMOID: PMO:00020567
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: JAK Kinases
Synonym: JAK kinase
Synonym: Janus Kinases [Chemical/Ingredient]
Synonym: Janus kinase
Synonym: Kinases, JAK
Synonym: Kinases, Janus
Tree Number: T6.10.3.86.46
database_cross_reference: CSP:4008-0057
database_cross_reference: MSH:D053612
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000175182

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
type: Class
subclass of: PMO:00021873
MCID: MC00740082
PMOID: PMO:00020573
Subclass_of: Parkinson Disease Associated Proteins
Synonym: Dardarin Protein
Synonym: LRRK2 Protein
Synonym: Leucine Rich Repeat Serine Threonine Protein Kinase 2
Synonym: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [Chemical/Ingredient]
Synonym: Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2
Synonym: PARK8 Protein
Tree Number: T6.10.3.2.1
database_cross_reference: MSH:D000071158
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000193017

Autophagy-Related Protein-1 Homolog
type: Class
subclass of: PMO:00021684
subclass of: PMO:00021879
MCID: MC01047426
PMOID: PMO:00020574
Subclass_of: Autophagy-Related Proteins
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Autophagy Related Protein 1 Homolog
Synonym: Autophagy-Related Protein-1 Homolog [Chemical/Ingredient]
Synonym: Serine Threonine Protein Kinase ULK1
Synonym: Serine-Threonine Protein Kinase ULK1
Synonym: ULK1 Protein
Synonym: Unc 51 Like Autophagy Activating Kinase 1
Synonym: Unc 51 Like Kinase 1
Synonym: Unc-51 Like Autophagy Activating Kinase 1
Synonym: Unc-51-Like Kinase 1
Tree Number: T6.10.2.33.2
Tree Number: T6.10.3.5.3
Tree Number: T6.10.3.86.1
database_cross_reference: MSH:D000071189
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000193092

NIMA-Related Kinases
type: Class
subclass of: PMO:00023838
MCID: MC01054804
PMOID: PMO:00020576
Subclass_of: Cell Cycle Proteins
Synonym: Kinases, NEK
Synonym: Kinases, NEK Family
Synonym: Kinases, NIMA Family
Synonym: Kinases, NIMA-Related
Synonym: Kinases, Never-in-Mitosis A
Synonym: NEK Family Kinases
Synonym: NEK Kinases
Synonym: NIMA Family Kinases
Synonym: NIMA Protein Kinase
Synonym: NIMA Related Kinases
Tree Number: T6.10.3.64.1
database_cross_reference: MSH:D000072379
database_cross_reference: NDFRT:N0000193125

WNK Lysine-Deficient Protein Kinase 1
type: Class
subclass of: PMO:00021684
PMOID: PMO:00020578
Subclass_of: Intracellular Signaling Peptides and Proteins
Tree Number: T6.10.2.33.9
Tree Number: T6.10.3.86.8

Cyclic Nucleotide-Regulated Protein Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00067590
PMOID: PMO:00020585
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: CYCL NUC REG KINASES
Synonym: Cyclic Nucleotide Regulated Protein Kinases
Synonym: Cyclic Nucleotide-Regulated Protein Kinases [Chemical/Ingredient]
Tree Number: T6.10.2.33.16
Tree Number: T6.10.3.86.15
database_cross_reference: MSH:D017867
database_cross_reference: NDFRT:N0000170595

Calcium-Calmodulin-Dependent Protein Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00002154
PMOID: PMO:00020598
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: CA 02 CALMODULIN DEPENDENT PROTEIN KINASE
Synonym: Ca(2+)-Calmodulin Dependent Protein Kinase
Synonym: Ca(2+)-Calmodulin Dependent Protein Kinase [Chemical/Ingredient]
Synonym: Ca(2+)-Calmodulin-Dependent Protein Kinase
Synonym: Calcium-Calmodulin Dependent Protein Kinases
Synonym: Calcium-Calmodulin-Dependent Protein Kinases [Chemical/Ingredient]
Synonym: Calmodulin Dependent Protein Kinases
Synonym: Calmodulin Kinase
Synonym: Calmodulin-Dependent Protein Kinases
Synonym: Calmodulin-Kinase
Tree Number: T6.10.2.33.17
Tree Number: T6.10.3.86.16
database_cross_reference: MSH:D017871
database_cross_reference: NDFRT:N0000170483
database_cross_reference: NDFRT:N0000178563

eIF-2 Kinase
type: Class
subclass of: PMO:00021684
MCID: MC00025731
PMOID: PMO:00020606
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Controlled Repressor, Heme
Synonym: Controlled Repressor, Hemin
Synonym: DAI Protein Kinase
Synonym: DSRNA Dep Protein Kinase
Synonym: DSRNA-Dep Protein Kinase
Synonym: Double Stranded RNA Dependent eIF 2 alpha Protein Kinase
Synonym: Double Stranded RNA-Dependent Kinase (dsl)
Synonym: Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
Synonym: EIF 02 A KINASE
Synonym: Eukaryotic Initiation Factor 2alpha Kinase
Tree Number: T6.10.2.33.20
Tree Number: T6.10.3.86.19
database_cross_reference: CHV:0000051591
database_cross_reference: CSP:2312-2490
database_cross_reference: MSH:D019892
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170522

Ribosomal Protein S6 Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00036843
PMOID: PMO:00020607
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: RIBOSOMAL PROTEIN KINASES S 06
Synonym: Ribosomal Protein S6 Kinase
Synonym: Ribosomal Protein S6 Kinases [Chemical/Ingredient]
Synonym: S A 006 KINASE
Synonym: S6 H4 Kinase
Synonym: S6 Kinase
Synonym: S6-H4 Kinase
Tree Number: T6.10.2.33.21
Tree Number: T6.10.3.86.20
database_cross_reference: MSH:D019893
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170592

Mitogen-Activated Protein Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00259341
PMOID: PMO:00020610
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: EC 2.7.2-
Synonym: ERK
Synonym: Extracellular Signal-Regulated Kinases
Synonym: Kinases, Mitogen-Activated Protein
Synonym: MAP kinase
Synonym: MAPK
Synonym: Map Kinase
Synonym: Mitogen Activated Protein Kinases
Synonym: Mitogen-Activated Protein Kinase
Synonym: Mitogen-Activated Protein Kinases [Chemical/Ingredient]
Tree Number: T6.10.2.33.25
Tree Number: T6.10.3.86.24
database_cross_reference: CHV:0000048568
database_cross_reference: CSP:4006-0064
database_cross_reference: LCH_NW:sh2005006737
database_cross_reference: LNC:LP36349-6
database_cross_reference: MSH:D020928
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16376
database_cross_reference: NDFRT:N0000170523

MAP Kinase Kinase Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00068899
PMOID: PMO:00020625
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Kinases, MAP Kinase Kinase
Synonym: Kinases, MAP3
Synonym: MAP Kinase Kinase Kinase
Synonym: MAP Kinase Kinase Kinases [Chemical/Ingredient]
Synonym: MAP3 Kinases
Synonym: MAPKKKs
Synonym: Mitogen Activated Protein Kinase Kinase Kinases
Synonym: Mitogen-Activated Protein Kinase Kinase Kinases
Tree Number: T6.10.2.33.27
Tree Number: T6.10.3.86.26
database_cross_reference: MSH:D020930
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170472

Glycogen Synthase Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00067379
PMOID: PMO:00020639
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Glycogen Synthase Kinase
Synonym: Glycogen Synthase Kinases [Chemical/Ingredient]
Synonym: Kinase, Glycogen Synthase
Synonym: Kinases, Glycogen Synthase
Synonym: Synthase Kinase, Glycogen
Tree Number: T6.10.2.33.30
Tree Number: T6.10.3.86.30
database_cross_reference: MSH:D038341
database_cross_reference: NDFRT:N0000170538

Cyclin-Dependent Kinases
type: Class
subclass of: PMO:00021684
subclass of: PMO:00023838
MCID: MC00081862
PMOID: PMO:00020641
Subclass_of: Cell Cycle Proteins
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: CDK
Synonym: Cyclin Dependent Kinase
Synonym: Cyclin Dependent Kinases
Synonym: Cyclin Dependent Protein Kinases
Synonym: Cyclin-Dependent Kinase
Synonym: Cyclin-Dependent Kinases [Chemical/Ingredient]
Synonym: Cyclin-Dependent Protein Kinases
Synonym: Cyclin-dependent kinases
Synonym: cdk Proteins
Synonym: cyclin dependent kinase
Tree Number: T6.10.2.33.18
Tree Number: T6.10.3.64.6
Tree Number: T6.10.3.86.17
database_cross_reference: CHV:0000025092
database_cross_reference: CSP:4008-0030
database_cross_reference: LCH_NW:sh97004870
database_cross_reference: MSH:D018844
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17767
database_cross_reference: NDFRT:N0000170541

CDC2 Protein Kinase
type: Class
subclass of: PMO:00023655
MCID: MC00041220
PMOID: PMO:00020643
Subclass_of: Phosphoproteins
Synonym: CDC 002 PROTEIN KINASE
Synonym: CDC2
Synonym: CDC2 Protein Kinase [Chemical/Ingredient]
Synonym: CDK PROTEIN KINASE 001
Synonym: CDK1
Synonym: CYCLIN DEPENDENT KINASE 001
Synonym: Cdk1 Protein Kinase
Synonym: Cell Cycle Controller cdc2
Synonym: Cell Division Control Protein 2 Homolog
Synonym: Cell Division Cycle 2
Tree Number: T6.10.3.40.6
database_cross_reference: CSP:2312-2490
database_cross_reference: CSP:4001-0024
database_cross_reference: MSH:D016203
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17386
database_cross_reference: NDFRT:N0000171014

Cyclin-Dependent Kinase 9
type: Class
subclass of: PMO:00020867
MCID: MC00085547
PMOID: PMO:00020646
Subclass_of: Multifunctional Enzymes
Synonym: CDK PROTEIN KINASE 009
Synonym: CDK9 Kinase
Synonym: CYCLIN DEPENDENT KINASE 009
Synonym: Cdc2 related Kinase PITALRE
Synonym: Cdc2-related Kinase PITALRE
Synonym: Cdk9 Protein Kinase
Synonym: Cyclin Dependent Kinase 9
Synonym: Cyclin-Dependent Kinase 9 [Chemical/Ingredient]
Synonym: Kinase PITALRE, Cdc2-related
Synonym: PITALRE Kinase
Tree Number: T6.7.4.18.7
database_cross_reference: MSH:D042863
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170545

Casein Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00022450
PMOID: PMO:00020653
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Casein Kinase
Synonym: Casein Kinases [Chemical/Ingredient]
Synonym: Kinase, Casein
Synonym: Kinases, Casein
Synonym: casein kinase
Tree Number: T6.10.3.86.31
database_cross_reference: CSP:4001-0021
database_cross_reference: MSH:D047388
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000170586

Proto-Oncogene Proteins c-akt
type: Class
subclass of: PMO:00021684
MCID: MC00064226
PMOID: PMO:00020655
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: AKT
Synonym: Akt
Synonym: Akt, Proto-Oncogene Protein
Synonym: Protein Kinase B
Synonym: Protein, akt Proto-Oncogene
Synonym: Protein, c-akt Proto-Oncogene
Synonym: Protein-Serine-Threonine Kinase (Rac)
Synonym: Proto Oncogene Protein Akt
Synonym: Proto Oncogene Protein RAC
Synonym: Proto Oncogene Proteins c akt
Tree Number: T6.10.3.86.36
database_cross_reference: CHV:0000031893
database_cross_reference: MSH:D051057
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C41625
database_cross_reference: NCI_NCI-GLOSS:CDR0000653105
database_cross_reference: NCI_NCI-GLOSS:CDR0000653106
database_cross_reference: NDFRT:N0000169095

I-kappa B Kinase
type: Class
subclass of: PMO:00021684
MCID: MC00218121
PMOID: PMO:00020657
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: B Kinase, I-kappa
Synonym: I kappa B Kinase
Synonym: I-Kappa-B Kinase
Synonym: I-kappa B Kinase [Chemical/Ingredient]
Synonym: IKK
Synonym: IKappaB Kinase
Synonym: IkappaB Kinase
Synonym: IkappaB Kinase Complex
Synonym: IkappaB kinase
Synonym: Inhibitor of Nuclear Factor Kappa-B Kinase
Tree Number: T6.10.2.33.36
Tree Number: T6.10.3.86.40
database_cross_reference: MSH:D051550
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C104199
database_cross_reference: NDFRT:N0000170485

Phytochrome A
type: Class
subclass of: PMO:00023658
MCID: MC00084031
PMOID: PMO:00020661
Subclass_of: Phytochrome
Synonym: PhyA Phytochrome
Synonym: Phytochrome A Protein
Synonym: Phytochrome A [Chemical/Ingredient]
Synonym: Phytochrome, PhyA
Tree Number: T6.13.7.12.2
database_cross_reference: MSH:D051942
database_cross_reference: NDFRT:N0000171198

Interleukin-1 Receptor-Associated Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00137234
PMOID: PMO:00020667
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: IL 1 Receptor Associated Kinase
Synonym: IL-1 Receptor-Associated Kinase
Synonym: INTERLEUKIN 001 RECEPTOR ASSOCIATED KINASES
Synonym: IRAK Kinases
Synonym: Interleukin 1 Receptor Associated Kinase
Synonym: Interleukin 1 Receptor Associated Kinases
Synonym: Interleukin-1 Receptor-Associated Kinase
Synonym: Interleukin-1 Receptor-Associated Kinases [Chemical/Ingredient]
Synonym: Kinase, IL-1 Receptor-Associated
Synonym: Kinase, Interleukin-1 Receptor-Associated
Tree Number: T6.10.2.33.40
Tree Number: T6.10.3.86.45
database_cross_reference: MSH:D053592
database_cross_reference: NDFRT:N0000175179

rho-Associated Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00138414
PMOID: PMO:00020668
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Coiled-Coil Kinase, rho-Associated
Synonym: Protein Kinases, ROCK
Synonym: ROCK Protein Kinases
Synonym: ROK Kinase
Synonym: rho Associated Coiled Coil Kinase
Synonym: rho Associated Kinase
Synonym: rho Associated Kinases
Synonym: rho Kinase
Synonym: rho-Associated Coiled-Coil Kinase
Synonym: rho-Associated Kinase
Tree Number: T6.10.2.33.41
Tree Number: T6.10.3.86.47
database_cross_reference: MSH:D054460
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178656

Lim Kinases
type: Class
subclass of: PMO:00021684
subclass of: PMO:00023927
MCID: MC00102687
PMOID: PMO:00020669
Subclass_of: Intracellular Signaling Peptides and Proteins
Subclass_of: LIM Domain Proteins
Synonym: Kinase, LIM
Synonym: Kinases, Lim
Synonym: LIM Domain Kinase 1
Synonym: LIM Kinase
Synonym: LIM Motif Containing Protein Kinases
Synonym: LIM Motif-Containing Protein Kinases
Synonym: LIM-Kinase
Synonym: Lim Kinases [Chemical/Ingredient]
Tree Number: T6.10.2.33.42
Tree Number: T6.10.3.86.48
Tree Number: T6.10.3.97.2
database_cross_reference: MSH:D054461
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000178644

p21-Activated Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00628738
PMOID: PMO:00020670
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: Kinases, PAK
Synonym: Kinases, p21-Activated
Synonym: P A 021 ACTIVATED KINASES
Synonym: PAK Kinases
Synonym: p21 Activated Kinases
Synonym: p21-Activated Kinases [Chemical/Ingredient]
Tree Number: T6.10.2.33.43
Tree Number: T6.10.3.86.49
database_cross_reference: MSH:D054462
database_cross_reference: NDFRT:N0000178775

G-Protein-Coupled Receptor Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00304788
PMOID: PMO:00020671
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: EC 2.7.1.-
Synonym: G Protein Coupled Receptor Kinase
Synonym: G Protein Coupled Receptor Kinases
Synonym: G Protein-Coupled Receptor Kinase
Synonym: G Protein-Coupled Receptor Kinase Family Protein
Synonym: G protein coupled receptor kinase
Synonym: G-Protein-Coupled Receptor Kinases [Chemical/Ingredient]
Synonym: GRK
Synonym: Kinases, G-Protein-Coupled Receptor
Synonym: Receptor Kinases, G-Protein-Coupled
Tree Number: T6.10.2.33.50
Tree Number: T6.10.3.86.56
database_cross_reference: CSP:5000-0065
database_cross_reference: MSH:D054768
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26233
database_cross_reference: NDFRT:N0000178697

G-Protein-Coupled Receptor Kinase 1
type: Class
subclass of: PMO:00022844
MCID: MC00036743
PMOID: PMO:00020675
Subclass_of: Eye Proteins
Synonym: G PROTEIN COUPLED RECEPTOR KINASE 001
Synonym: G Protein Coupled Receptor Kinase 1
Synonym: G Protein-Coupled Receptor Kinase 1
Synonym: G-Protein-Coupled Receptor Kinase 1 [Chemical/Ingredient]
Synonym: Kinase, Opsin
Synonym: Kinase, Rhodopsin
Synonym: Opsin Kinase
Synonym: Opsin kinase
Synonym: Opsin kinase (substance)
Synonym: Rhodopsin Kinase
Tree Number: T6.10.3.21.6
database_cross_reference: CSP:4007-0108
database_cross_reference: MSH:D051606
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000169039
database_cross_reference: SNMI:F-692A0
database_cross_reference: SNOMEDCT_US:130427008
database_cross_reference: SNOMEDCT_US:8149002

AMP-Activated Protein Kinases
type: Class
subclass of: PMO:00021684
MCID: MC00715418
PMOID: PMO:00020678
Subclass_of: Intracellular Signaling Peptides and Proteins
Synonym: 5' AMP Activated Protein Kinase
Synonym: 5' AMP-Activated Protein Kinase
Synonym: 5' Adenosine Monophosphate-Activated Protein Kinase
Synonym: 5'-AMP-Activated Protein Kinase
Synonym: AMP Activated Kinase
Synonym: AMP Activated Protein Kinase
Synonym: AMP Activated Protein Kinases
Synonym: AMP-Activated Kinase
Synonym: AMP-Activated Protein Kinase
Synonym: AMP-Activated Protein Kinases [Chemical/Ingredient]
Tree Number: T6.10.2.33.53
Tree Number: T6.10.3.86.59
database_cross_reference: MSH:D055372
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94701
database_cross_reference: NDFRT:N0000178836