PMO
type: Ontology
creator: Institute of Medical Information, Chinese Academy of Medical Sciences/Peking Union Medical College
description: PMO is an open, extensible ontology aimed to integrate the terms in field of precision medicine.

definition
type: AnnotationProperty

Example
type: AnnotationProperty
definition: The example of the relationship appearing in biomedical text.

MRID
type: AnnotationProperty
definition: The unique identifier of the relationship in PMO.

PMOID
type: AnnotationProperty
definition: The unique identifier of the class in PMO.

Source of Example
type: AnnotationProperty
definition: The source of the example, usually PubMed.

Subclass_of
type: AnnotationProperty
definition: The superclass of the resource.

Synonym
type: AnnotationProperty
definition: The synonym of the resource in other databases.

Tree Number
type: AnnotationProperty
definition: The hierarchy of the resource in PMO tree.

database_cross_reference
type: AnnotationProperty
definition: The ID of the resource in other databases.

disease of metabolism
type: Class
subclass of: Disease
definition: A disease that involving errors in metabolic processes of building or degradation of molecules.
PMOID: PMO:00028838
Subclass_of: Disease
Synonym: DIS METAB
Synonym: Disease, Metabolic
Synonym: Disease;metabolic
Synonym: Diseases, Metabolic
Synonym: Disorder of metabolism NOS
Synonym: Disorder of metabolism NOS (disorder)
Synonym: Disorder;metabolic
Synonym: Generalised metabolic disorder
Synonym: Generalized metabolic disorder
Synonym: Generalized metabolic disorder (disorder)
Tree Number: T10.6
database_cross_reference: AOD:0000005711
database_cross_reference: CHV:0000007997
database_cross_reference: CSP:1846-2030
database_cross_reference: CST:MET
database_cross_reference: CST:METGEN
database_cross_reference: DO:DOID:0014667
database_cross_reference: ICD10:E70-E90.9
database_cross_reference: ICD10:E88.9
database_cross_reference: ICD10AM:E70-E90.9
database_cross_reference: ICD10AM:E88.9
database_cross_reference: ICD10CM:E88.9
database_cross_reference: ICD9CM:277.9
database_cross_reference: ICPC2P:T99010
database_cross_reference: ICPC2P:T99058
database_cross_reference: LCH_NW:sh85084014
database_cross_reference: MDR:10027426
database_cross_reference: MDR:10045811
database_cross_reference: MDR:10058097
database_cross_reference: MEDCIN:314308
database_cross_reference: MEDCIN:38671
database_cross_reference: MEDLINEPLUS:1703
database_cross_reference: MSH:D008659
database_cross_reference: NCI:C3235
database_cross_reference: NCI_NCI-GLOSS:CDR0000044055
database_cross_reference: NCI_NICHD:C3235
database_cross_reference: NDFRT:N0000002004
database_cross_reference: PSY:31020
database_cross_reference: RCD:Cyu8.
database_cross_reference: RCD:XE11s
database_cross_reference: SNM:D-1000
database_cross_reference: SNMI:D6-00000
database_cross_reference: SNMI:D6-00020
database_cross_reference: SNOMEDCT_US:154733004
database_cross_reference: SNOMEDCT_US:190961002
database_cross_reference: SNOMEDCT_US:267456000
database_cross_reference: SNOMEDCT_US:30390004
database_cross_reference: SNOMEDCT_US:75934005
database_cross_reference: SNOMEDCT_VET:75934005

bacterial sepsis
type: Class
subclass of: bacterial infectious disease
definition: A bacterial infectious disease has_material_basis_in Bacteria.
PMOID: PMO:00029615
Subclass_of: bacterial infectious disease
Synonym: Generalized infection
Synonym: INFECTION SYSTEMIC
Synonym: Infection systemic
Synonym: Infection, systemic
Synonym: Infectious systemic inflammatory response syndrome
Synonym: Infectious systemic inflammatory response syndrome (disorder)
Synonym: SEPSIS
Synonym: Sepsis
Synonym: Sepsis (disorder)
Synonym: Sepsis NOS
Tree Number: T10.7.3.6
database_cross_reference: AOD:0000004500
database_cross_reference: CCPSS:1015013
database_cross_reference: CHV:0000025081
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:5003-0039
database_cross_reference: CST:SEPSIS
database_cross_reference: DO:DOID:0040085
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD9CM:995.91
database_cross_reference: LNC:LA10591-8
database_cross_reference: MDR:10021867
database_cross_reference: MDR:10040047
database_cross_reference: MDR:10040050
database_cross_reference: MDR:10077116
database_cross_reference: MEDLINEPLUS:3210
database_cross_reference: MSH:D018805
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003861
database_cross_reference: OMIM:MTHU010579
database_cross_reference: OMIM:MTHU055817
database_cross_reference: RCD:X70VZ
database_cross_reference: SNM:D-0071
database_cross_reference: SNM:D-0080
database_cross_reference: SNMI:DE-00020
database_cross_reference: SNOMEDCT_US:186392004
database_cross_reference: SNOMEDCT_US:445101001
database_cross_reference: SNOMEDCT_US:91302008
database_cross_reference: SNOMEDCT_VET:91302008

Polyomavirus-associated Nephropathy
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease has_material_basis_in BK polyomavirus.
PMOID: PMO:00029417
Subclass_of: viral infectious disease
Synonym: polyomavirus associated nephropathy
Synonym: PVAN
Synonym: Polyomavirus-associated nephropathy
Tree Number: T10.7.2.52
database_cross_reference: DO:DOID:0040086
database_cross_reference: MDR:10065381

chikungunya
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash.
PMOID: PMO:00029424
Subclass_of: viral infectious disease
Synonym: Chikungunya fever
Tree Number: T10.7.2.58
database_cross_reference: DO:DOID:0050012

carbohydrate metabolism disease
type: Class
subclass of: acquired metabolic disease
definition: An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism.
PMOID: PMO:00028853
Subclass_of: acquired metabolic disease
Tree Number: T10.6.1.3
database_cross_reference: DO:DOID:0050013

mineral metabolism disease
type: Class
subclass of: acquired metabolic disease
definition: An acquired metabolic disease that is characterized by abnormal mineral metabolism.
PMOID: PMO:00028922
Subclass_of: acquired metabolic disease
Tree Number: T10.6.1.5
database_cross_reference: DO:DOID:0050032

erysipeloid
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin.
PMOID: PMO:00029509
Subclass_of: primary bacterial infectious disease
Synonym: E-119 ERYSIPELOTHRIX INFECTIONS
Synonym: ERYSIPELOTHRIX INFECT
Synonym: ERYSIPELOTHRIX INFECTIONS
Synonym: Erysipeloid
Synonym: Erysipeloid (disorder)
Synonym: Erysipelothrix
Synonym: Erysipelothrix (disease)
Synonym: Erysipelothrix Infection
Synonym: Erysipelothrix Infections
Synonym: Erysipelothrix Infections [Disease/Finding]
Tree Number: T10.7.3.1.15
database_cross_reference: CHV:0000004611
database_cross_reference: DO:DOID:0050061
database_cross_reference: ICD9CM:027.1
database_cross_reference: MDR:10015148
database_cross_reference: MDR:10015149
database_cross_reference: MEDCIN:36238
database_cross_reference: MSH:D004889
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001143
database_cross_reference: RCD:A2710
database_cross_reference: RCD:A271z
database_cross_reference: RCD:XE0Qs
database_cross_reference: SNM:D-0122
database_cross_reference: SNMI:DE-11900
database_cross_reference: SNOMEDCT_US:186321002
database_cross_reference: SNOMEDCT_US:186322009
database_cross_reference: SNOMEDCT_US:186325006
database_cross_reference: SNOMEDCT_US:266085005
database_cross_reference: SNOMEDCT_US:367434002

disease by infectious agent
type: Class
subclass of: Disease
definition: A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions.
PMOID: PMO:00029283
Subclass_of: Disease
Synonym: Adenovirus infect NOS
Synonym: Adenovirus infection in conditions classified elsewhere and of unspecified site
Synonym: infectious disease
Tree Number: T10.7
database_cross_reference: DO:DOID:0050117
database_cross_reference: ICD9CM:079.0
database_cross_reference: MDR:10001263

La Crosse encephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.
PMOID: PMO:00029457
Subclass_of: viral infectious disease
Synonym: CALIFORNIA ENCEPH
Synonym: CALIFORNIA VIRAL ENCEPH
Synonym: CE - California encephalitis
Synonym: California Encephalitis
Synonym: California Viral Encephalitides
Synonym: California Viral Encephalitis
Synonym: California encephalitis
Synonym: California encephalitis (diagnosis)
Synonym: California encephalitis virus disease
Synonym: California encephalitis virus disease (disorder)
Tree Number: T10.7.2.86
database_cross_reference: DO:DOID:0050118
database_cross_reference: DXP:U000530
database_cross_reference: ICD10:A83.5
database_cross_reference: ICD10AM:A83.5
database_cross_reference: ICD10CM:A83.5
database_cross_reference: ICD9CM:062.5
database_cross_reference: MDR:10007032
database_cross_reference: MDR:10007033
database_cross_reference: MDR:10014584
database_cross_reference: MEDCIN:30855
database_cross_reference: MSH:D004670
database_cross_reference: MTHICD9:062.5
database_cross_reference: NDFRT:N0000001077
database_cross_reference: RCD:XE0RG
database_cross_reference: SNM:D-0366
database_cross_reference: SNMI:DE-34520
database_cross_reference: SNOMEDCT_US:186588007
database_cross_reference: SNOMEDCT_US:266103004
database_cross_reference: SNOMEDCT_US:416442006
database_cross_reference: SNOMEDCT_US:417075004
database_cross_reference: SNOMEDCT_US:418531007
database_cross_reference: SNOMEDCT_US:69627004

hemophagocytic lymphohistiocytosis
type: Class
subclass of: lymphatic system disease
definition: A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.
PMOID: PMO:00032918
Subclass_of: lymphatic system disease
Synonym: HLH
Synonym: HPS
Synonym: Haemophagocyt lymphohistiocyto
Synonym: Haemophagocytic lymphohistiocytosis
Synonym: Haemophagocytic lymphohistiocytosis (disorder)
Synonym: Hemophagocytic Disorder
Synonym: Hemophagocytic Lymphohistiocytoses
Synonym: Hemophagocytic Lymphohistiocytosis
Synonym: Hemophagocytic Syndrome
Synonym: Hemophagocytic Syndromes
Tree Number: T10.8.6.4.3
database_cross_reference: DO:DOID:0050120
database_cross_reference: ICD10:D76.1
database_cross_reference: ICD10AM:D76.1
database_cross_reference: ICD10CM:D76.1
database_cross_reference: MDR:10071580
database_cross_reference: MDR:10071583
database_cross_reference: MEDCIN:351297
database_cross_reference: MSH:D051359
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34792
database_cross_reference: NCI_NCI-GLOSS:CDR0000488415
database_cross_reference: NCI_NCI-GLOSS:CDR0000523322
database_cross_reference: NDFRT:N0000171663
database_cross_reference: OMIM:MTHU038295
database_cross_reference: PDQ:CDR0000486910
database_cross_reference: RCD:X20E8
database_cross_reference: SNOMEDCT_US:190958003
database_cross_reference: SNOMEDCT_US:234437005

dengue shock syndrome
type: Class
subclass of: dengue disease
definition: A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.
PMOID: PMO:00029385
Subclass_of: dengue disease
Synonym: DSS
Synonym: Dengue Shock Syndrome
Synonym: Dengue shock syndrome
Synonym: Dengue shock syndrome (disorder)
Tree Number: T10.7.2.33.2
database_cross_reference: DO:DOID:0050125
database_cross_reference: MSH:D019595
database_cross_reference: SNOMEDCT_US:409671005

secretory diarrhea
type: Class
subclass of: diarrhea
definition: Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.
PMOID: PMO:00033745
Subclass_of: diarrhea
Synonym: Diarrhea, secretory
Synonym: Secretory diarrhea
Synonym: Secretory diarrhea (disorder)
Synonym: Secretory diarrhoea
Synonym: secretory diarrhoea
Tree Number: T10.8.11.14.3
database_cross_reference: CHV:0000026180
database_cross_reference: DO:DOID:0050129
database_cross_reference: HPO:HP:0005208
database_cross_reference: MDR:10039894
database_cross_reference: MDR:10055960
database_cross_reference: OMIM:MTHU007814
database_cross_reference: RCD:X30Bu
database_cross_reference: RCDAE:X30Bu
database_cross_reference: SNMI:D5-44491
database_cross_reference: SNOMEDCT_US:15699003

osmotic diarrhea
type: Class
subclass of: diarrhea
definition: Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.
PMOID: PMO:00033756
Subclass_of: diarrhea
Synonym: Osmotic diarrhea
Synonym: Osmotic diarrhea (disorder)
Synonym: Osmotic diarrhoea
Synonym: Permeability diarrhea
Synonym: Permeability diarrhoea
Tree Number: T10.8.11.14.6
database_cross_reference: CHV:0000026179
database_cross_reference: DO:DOID:0050130
database_cross_reference: MDR:10057036
database_cross_reference: MDR:10073887
database_cross_reference: RCD:X30Br
database_cross_reference: RCDAE:X30Br
database_cross_reference: SNMI:D5-44490
database_cross_reference: SNOMEDCT_US:2946003

motility-related diarrhea
type: Class
subclass of: diarrhea
definition: Motility-related diarrhea is a diarrhea which is caused by the rapid movement of food through the intestines (hypermotility). If the food moves too quickly through the GI tract, there is not enough time for sufficient nutrients and water to be absorbed.
PMOID: PMO:00033743
Subclass_of: diarrhea
Tree Number: T10.8.11.14.1
database_cross_reference: DO:DOID:0050131

inflammatory diarrhea
type: Class
subclass of: diarrhea
definition: A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.
PMOID: PMO:00033744
Subclass_of: diarrhea
Synonym: Inflammatory diarrhea
Synonym: Inflammatory diarrhea (disorder)
Synonym: Inflammatory diarrhoea
Synonym: diarrhea inflammatory
Tree Number: T10.8.11.14.2
database_cross_reference: CHV:0000037993
database_cross_reference: DO:DOID:0050132
database_cross_reference: SNMI:D5-43250
database_cross_reference: SNOMEDCT_US:95544006

superficial mycosis
type: Class
subclass of: fungal infectious disease
definition: A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Trichosporon beigelii. Infected hairs develop soft greyish-white nodules along the shaft.
PMOID: PMO:00029285
Subclass_of: fungal infectious disease
Synonym: Piedra
Synonym: Piedra (disorder)
Synonym: Piedra [Disease/Finding]
Synonym: Piedras
Synonym: Steroid-modified tinea infection
Synonym: Tinea blanca
Synonym: White piedra
Synonym: black piedra
Synonym: piedra
Synonym: piedras
Tree Number: T10.7.1.1
database_cross_reference: CHV:0000009730
database_cross_reference: DO:DOID:0050133
database_cross_reference: DO:DOID:12711
database_cross_reference: DO:DOID:13902
database_cross_reference: MSH:D010854
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002400
database_cross_reference: SNM:D-0583
database_cross_reference: SNOMEDCT_US:154408001
database_cross_reference: SNOMEDCT_US:266218008
database_cross_reference: SNOMEDCT_US:402135006

cutaneous mycosis
type: Class
subclass of: fungal infectious disease
definition: A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.
PMOID: PMO:00029290
Subclass_of: fungal infectious disease
Synonym: Cutaneous fungal disease
Synonym: Cutaneous mycosis
Synonym: Cutaneous mycosis, NOS
Synonym: DERMATITIS FUNGAL
Synonym: DERMATITIS FUNGOID
Synonym: DERMATOMYCOSIS
Synonym: Dermal mycosis
Synonym: Dermal mycosis (disorder)
Synonym: Dermal mycosis, NOS
Synonym: Dermatitis fungal
Tree Number: T10.7.1.2
database_cross_reference: CCPSS:0023188
database_cross_reference: CCPSS:0056231
database_cross_reference: CCPSS:0058682
database_cross_reference: CHV:0000003799
database_cross_reference: COSTAR:227
database_cross_reference: CSP:1988-4704
database_cross_reference: CST:DERM FUNG
database_cross_reference: DO:DOID:0050134
database_cross_reference: DO:DOID:1563
database_cross_reference: ICD9CM:111
database_cross_reference: ICD9CM:111.9
database_cross_reference: ICPC2P:S74002
database_cross_reference: ICPC2P:S74005
database_cross_reference: ICPC2P:S74006
database_cross_reference: ICPC2P:S74012
database_cross_reference: LCH:U001358
database_cross_reference: LCH_NW:sh85037095
database_cross_reference: MDR:10012463
database_cross_reference: MDR:10012464
database_cross_reference: MDR:10012465
database_cross_reference: MDR:10012501
database_cross_reference: MDR:10012502
database_cross_reference: MDR:10017526
database_cross_reference: MDR:10017527
database_cross_reference: MDR:10017543
database_cross_reference: MDR:10040853
database_cross_reference: MDR:10050578
database_cross_reference: MEDCIN:90182
database_cross_reference: MEDCIN:97629
database_cross_reference: MSH:D003881
database_cross_reference: NDFRT:N0000000945
database_cross_reference: OMIM:MTHU044478
database_cross_reference: RCD:AB1z.
database_cross_reference: RCD:X70QJ
database_cross_reference: SNM:D-0575
database_cross_reference: SNMI:DE-40040
database_cross_reference: SNMI:DE-45000
database_cross_reference: SNOMEDCT_US:14560005
database_cross_reference: SNOMEDCT_US:186984003
database_cross_reference: SNOMEDCT_US:187004009
database_cross_reference: SNOMEDCT_US:47382004

subcutaneous mycosis
type: Class
subclass of: fungal infectious disease
definition: A fungal infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Fungi, which penetrate the dermis or even deeper during or after a skin trauma.
PMOID: PMO:00029307
Subclass_of: fungal infectious disease
Tree Number: T10.7.1.3
database_cross_reference: DO:DOID:0050135

systemic mycosis
type: Class
subclass of: fungal infectious disease
definition: A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs.
PMOID: PMO:00029311
Subclass_of: fungal infectious disease
Synonym: Disseminated mycosis
Synonym: Disseminated mycosis (disorder)
Synonym: Systemic fungal infection
Synonym: Systemic fungal infection NOS
Synonym: Systemic fungal infection, NOS
Synonym: Systemic mycosis
Synonym: Systemic mycosis (diagnosis)
Synonym: Systemic mycosis (disorder)
Synonym: Systemic mycosis, NOS
Synonym: fungal infection systemic
Tree Number: T10.7.1.4
database_cross_reference: CHV:0000039088
database_cross_reference: DO:DOID:0050136
database_cross_reference: MDR:10042941
database_cross_reference: MDR:10052366
database_cross_reference: MEDCIN:355634
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X70QG
database_cross_reference: RCD:X70QH
database_cross_reference: SNMI:DE-40020
database_cross_reference: SNOMEDCT_US:240694001
database_cross_reference: SNOMEDCT_US:399314004
database_cross_reference: SNOMEDCT_US:57202009

acute diarrhea
type: Class
subclass of: diarrhea
definition: A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.
PMOID: PMO:00033749
Subclass_of: diarrhea
Synonym: Acute diarrhea
Synonym: Acute diarrhea (disorder)
Synonym: Acute diarrhoea
Synonym: DIARRHEA ACUTE
Synonym: Diarrhea;acute
Synonym: Diarrhoea;acute
Synonym: acute diarrhoea
Tree Number: T10.8.11.14.4
database_cross_reference: CCPSS:0018089
database_cross_reference: CHV:0000047129
database_cross_reference: DO:DOID:0050140
database_cross_reference: ICPC2P:D11008
database_cross_reference: MDR:10000706
database_cross_reference: MDR:10055955
database_cross_reference: SNOMEDCT_US:409966000

asymptomatic dengue
type: Class
subclass of: dengue disease
definition: A dengue disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has no manifestations of symptoms.
PMOID: PMO:00029386
Subclass_of: dengue disease
Tree Number: T10.7.2.33.3
database_cross_reference: DO:DOID:0050143

Kartagener syndrome
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by sinusitis, bronchiectasis and situs inversus with dextrocardia resulting from dysfunction of the cilia during embryologic development.
PMOID: PMO:00028335
Subclass_of: primary ciliary dyskinesia
Synonym: Bronchiectasis, Polynesian
Synonym: Bronchiectasis, chronic sinusitis AND dextrocardia syndrome
Synonym: Bronchiectasis, chronic sinusitis and dextrocardia syndrome
Synonym: Bronchiectasis-chronic sinusitis and dextrocardia syndrome
Synonym: CILD1
Synonym: Ciliary Dyskinesia, Primary
Synonym: DEXTROCARDIA, BRONCHIECTASIS, AND SINUSITIS
Synonym: DEXTROCARDIA-BRONCHIECTASIS-SINUSITIS SYNDROME
Synonym: Dextrocardia, Bronchiectasis, and Sinusitis
Synonym: Dyskinesia, Primary Ciliary
Tree Number: T10.5.1.3.1
database_cross_reference: CCPSS:0047908
database_cross_reference: CHV:0000007042
database_cross_reference: DO:DOID:0050144
database_cross_reference: DO:DOID:0110594
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000964
database_cross_reference: MDR:10023299
database_cross_reference: MEDCIN:33028
database_cross_reference: MSH:D007619
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84797
database_cross_reference: NDFRT:N0000001731
database_cross_reference: OMIM:244400
database_cross_reference: RCD:PK35.
database_cross_reference: RCD:X101Z
database_cross_reference: SNM:D-7719
database_cross_reference: SNMI:D4-01516
database_cross_reference: SNOMEDCT_US:42402006
database_cross_reference: SNOMEDCT_US:86204009

adenoiditis
type: Class
subclass of: upper respiratory tract disease
PMOID: PMO:00032489
Subclass_of: upper respiratory tract disease
Synonym: Adenoiditis
Synonym: Adenoiditis (disorder)
Synonym: Adenoiditis, NOS
Synonym: adenoiditis (diagnosis)
Synonym: inflammation of adenoids
Synonym: inflammation of adenoids (physical finding)
Tree Number: T10.8.5.2.6
database_cross_reference: CHV:0000000713
database_cross_reference: HPO:HP:0031458
database_cross_reference: ICPC2P:R76007
database_cross_reference: ICPC2P:R90013
database_cross_reference: MDR:10051223
database_cross_reference: MEDCIN:62585
database_cross_reference: MEDCIN:91375
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:DC-71730
database_cross_reference: SNOMEDCT_US:70020005

laryngotracheitis
type: Class
subclass of: upper respiratory tract disease
definition: A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.
PMOID: PMO:00032490
Subclass_of: upper respiratory tract disease
Synonym: Acute Obstructive Laryngitis
Synonym: Acute laryngotracheobronchitis
Synonym: Acute laryngotracheobronchitis (disorder)
Synonym: Acute obstructive laryngitis [croup]
Synonym: CROUP
Synonym: Croup
Synonym: Croup (disorder)
Synonym: Croup [Disease/Finding]
Synonym: Croup syndrome
Synonym: LARYNGOTRACHEOBRONCHITIS, ACUTE
Tree Number: T10.8.5.2.7
database_cross_reference: CCPSS:0059159
database_cross_reference: CHV:0000003477
database_cross_reference: COSTAR:213
database_cross_reference: CST:LARYNGITIS
database_cross_reference: DO:DOID:9395
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000907
database_cross_reference: DXP:U001010
database_cross_reference: ICD10:J05.0
database_cross_reference: ICD10AM:J05.0
database_cross_reference: ICD10CM:J05.0
database_cross_reference: ICD9CM:464.4
database_cross_reference: ICPC2P:R77001
database_cross_reference: LCH:U001207
database_cross_reference: LCH_NW:sh85034323
database_cross_reference: MDR:10011415
database_cross_reference: MEDCIN:34102
database_cross_reference: MEDLINEPLUS:6292
database_cross_reference: MSH:D003440
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:464.4
database_cross_reference: NCI:C26735
database_cross_reference: NCI_NICHD:C26735
database_cross_reference: NDFRT:N0000000877
database_cross_reference: RCD:Xa0lW
database_cross_reference: SNM:D-7504
database_cross_reference: SNMI:D2-04160
database_cross_reference: SNOMEDCT_US:155510007
database_cross_reference: SNOMEDCT_US:195702002
database_cross_reference: SNOMEDCT_US:71186008

sensory system disease
type: Class
subclass of: nervous system disease
definition: A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell).
PMOID: PMO:00030718
Subclass_of: nervous system disease
Tree Number: T10.8.2.11
database_cross_reference: DO:DOID:0050155

lower respiratory tract disease
type: Class
subclass of: respiratory system disease
definition: A respiratory system disease which involves the lower respiratory tract.
PMOID: PMO:00032506
Subclass_of: respiratory system disease
Synonym: Nasal & sinus dis NEC
Synonym: Other disease of nasal cavity and sinuses
Synonym: Other diseases of nasal cavity and sinuses
Synonym: Other nasal cavity and sinus disease
Synonym: Other nasal cavity and sinus disease (disorder)
Synonym: Other nasal cavity/sinus dis.
Synonym: upper respiratory tract disease
Tree Number: T10.8.5.4
database_cross_reference: DO:DOID:0050161
database_cross_reference: DO:DOID:974
database_cross_reference: ICD9CM:478.1
database_cross_reference: ICD9CM:478.19
database_cross_reference: MDR:10031910
database_cross_reference: RCD:XE0Y8
database_cross_reference: SNOMEDCT_US:195823002
database_cross_reference: SNOMEDCT_US:266346007

Kunjin encephalitis
type: Class
subclass of: West Nile encephalitis
definition: A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy.
PMOID: PMO:00029452
Subclass_of: West Nile encephalitis
Tree Number: T10.7.2.81.1
database_cross_reference: DO:DOID:0050174

tick-borne encephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.
PMOID: PMO:00029438
Subclass_of: viral infectious disease
Synonym: Central European encephalitis
Synonym: ENCEPH LOUPING ILL
Synonym: Encephalitides, Louping Ill
Synonym: Encephalitis, Louping Ill
Synonym: Far Eastern TBE
Synonym: LOUPING ILL ENCEPH
Synonym: Louping Ill Encephalitides
Synonym: Louping Ill Encephalitis
Synonym: Louping ill encephalitis
Synonym: Russian spring-summer encephalitis
Tree Number: T10.7.2.70
database_cross_reference: DO:DOID:0050175
database_cross_reference: MSH:D004675
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:A631.
database_cross_reference: SNOMEDCT_US:59350003

monogenic disease
type: Class
subclass of: genetic disease
definition: A genetic disease that is the result of one or more abnormal alleles and may be dominant (a single copy of the abnormal allele is sufficient to give rise to the disease), semi-dominant, or recessive (requiring both copies of the gene to have an abnormal allele).
PMOID: PMO:00028386
Subclass_of: genetic disease
Tree Number: T10.5.3
database_cross_reference: DO:DOID:0050177

Powassan encephalitis
type: Class
subclass of: tick-borne encephalitis
definition: A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.
PMOID: PMO:00029439
Subclass_of: tick-borne encephalitis
Tree Number: T10.7.2.70.1
database_cross_reference: DO:DOID:0050179

erythema multiforme
type: Class
subclass of: skin disease
definition: A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness.
PMOID: PMO:00033863
Subclass_of: skin disease
Synonym: EM
Synonym: EM - Erythema multiforme
Synonym: ERYTHEMA MULTIFORME
Synonym: Erythaema polymorphe
Synonym: Erythema Multiforme
Synonym: Erythema Multiforme [Disease/Finding]
Synonym: Erythema multiforme
Synonym: Erythema multiforme (disorder)
Synonym: Erythema multiforme NOS
Synonym: Erythema multiforme NOS (disorder)
Tree Number: T10.8.12.2.11
database_cross_reference: CCPSS:1014653
database_cross_reference: CHV:0000004615
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2716-6944
database_cross_reference: CST:ERYTHEMA MULT
database_cross_reference: DO:DOID:0050185
database_cross_reference: DXP:U000589
database_cross_reference: DXP:U001155
database_cross_reference: ICD10:L51
database_cross_reference: ICD10:L51.9
database_cross_reference: ICD10AM:L51
database_cross_reference: ICD10AM:L51.9
database_cross_reference: ICD10CM:L51
database_cross_reference: ICD10CM:L51.9
database_cross_reference: ICD9CM:695.1
database_cross_reference: ICD9CM:695.10
database_cross_reference: ICPC2P:S99007
database_cross_reference: LCH:U001647
database_cross_reference: LCH_NW:sh85044741
database_cross_reference: MDR:10014493
database_cross_reference: MDR:10015218
database_cross_reference: MDR:10057783
database_cross_reference: MDR:10057866
database_cross_reference: MEDCIN:33138
database_cross_reference: MSH:D004892
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3024
database_cross_reference: NCI_CTCAE:E13627
database_cross_reference: NCI_NICHD:C3024
database_cross_reference: NDFRT:N0000001146
database_cross_reference: RCD:M151z
database_cross_reference: RCD:XE1B0
database_cross_reference: SNM:M-48560
database_cross_reference: SNMI:D0-10450
database_cross_reference: SNOMEDCT_US:156362004
database_cross_reference: SNOMEDCT_US:200919006
database_cross_reference: SNOMEDCT_US:200928007
database_cross_reference: SNOMEDCT_US:267848009
database_cross_reference: SNOMEDCT_US:36715001

Argentine hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.
PMOID: PMO:00029416
Subclass_of: viral infectious disease
Synonym: AHF - Argentinian haem fever
Synonym: AHF - Argentinian haemorrhagic fever
Synonym: AHF - Argentinian hemorrhagic fever
Synonym: Argentine fever
Synonym: Argentine haemorrhagic fever
Synonym: Argentine hemorrhagic fever (diagnosis)
Synonym: Argentinian Hemorrhagic Fever
Synonym: Argentinian haemorrhagic fever
Synonym: Argentinian haemorrhagic fever (disorder)
Synonym: Argentinian hemorrhagic fever
Tree Number: T10.7.2.51
database_cross_reference: CHV:0000006014
database_cross_reference: DO:DOID:0050194
database_cross_reference: DXP:U000801
database_cross_reference: ICD10:A96.0
database_cross_reference: ICD10AM:A96.0
database_cross_reference: ICD10AMAE:A96.0
database_cross_reference: ICD10CM:A96.0
database_cross_reference: MDR:10003090
database_cross_reference: MDR:10023247
database_cross_reference: MDR:10055229
database_cross_reference: MEDCIN:36286
database_cross_reference: MSH:D006478
database_cross_reference: MTHICD9:078.7
database_cross_reference: RCD:X70L5
database_cross_reference: RCDAE:X70L5
database_cross_reference: SNM:D-0481
database_cross_reference: SNMI:DE-34A22
database_cross_reference: SNOMEDCT_US:186702008
database_cross_reference: SNOMEDCT_US:186703003
database_cross_reference: SNOMEDCT_US:58868000
database_cross_reference: SNOMEDCT_US:721778009

Bolivian hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.
PMOID: PMO:00029426
Subclass_of: viral infectious disease
Synonym: BHF - Bolivian haemorr fever
Synonym: BHF - Bolivian haemorrhagic fever
Synonym: BHF - Bolivian hemorrhagic fever
Synonym: Black typhus
Synonym: Bolivian Hemorrhagic Fever
Synonym: Bolivian fever
Synonym: Bolivian haemorrhagic fever
Synonym: Bolivian haemorrhagic fever (disorder)
Synonym: Bolivian hemorrhagic fever (diagnosis)
Synonym: Bolivian hemorrhagic fever (disorder)
Tree Number: T10.7.2.60
database_cross_reference: DO:DOID:0050195
database_cross_reference: ICD10:A96.1
database_cross_reference: ICD10AM:A96.1
database_cross_reference: ICD10AMAE:A96.1
database_cross_reference: ICD10CM:A96.1
database_cross_reference: MDR:10005932
database_cross_reference: MDR:10055233
database_cross_reference: MEDCIN:36287
database_cross_reference: MSH:D006478
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:078.7
database_cross_reference: RCD:X70L6
database_cross_reference: RCDAE:X70L6
database_cross_reference: SNM:D-0481
database_cross_reference: SNMI:DE-34A23
database_cross_reference: SNOMEDCT_US:186702008
database_cross_reference: SNOMEDCT_US:186704009
database_cross_reference: SNOMEDCT_US:67247008

Venezuelan hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.
PMOID: PMO:00029429
Subclass_of: viral infectious disease
Synonym: Guanarito haemorrhagic fever
Synonym: Guanarito hemorrhagic fever
Synonym: Venezuelan haemorrhagic fever
Synonym: Venezuelan haemorrhagic fever (disorder)
Synonym: Venezuelan haemorrhagic fever [Ambiguous]
Synonym: Venezuelan hemorrhagic fever (disorder)
Tree Number: T10.7.2.63
database_cross_reference: DO:DOID:0050196
database_cross_reference: RCD:A662.
database_cross_reference: RCDAE:A662.
database_cross_reference: SNOMEDCT_US:186609008
database_cross_reference: SNOMEDCT_US:359673001

Brazilian hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has material basis in Sabia virus, which is transmitted by rodents. The infection has symptom fever, has symptom eye redness, has symptom fatigue, has symptom dizziness, has symptom muscle aches, has symptom loss of strength, and has symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.
PMOID: PMO:00029381
Subclass_of: viral infectious disease
Synonym: Brazilian haemorrhagic fever
Synonym: Brazilian hemorrhagic fever (disorder)
Synonym: Sabia haemorrhagic fever
Synonym: Sabia hemorrhagic fever
Tree Number: T10.7.2.31
database_cross_reference: DO:DOID:0050197
database_cross_reference: RCD:X70L8
database_cross_reference: RCDAE:X70L8
database_cross_reference: SNOMEDCT_US:240524001

Chapare hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has material basis in Chapare virus. The infection has symptom headache, has symptom joint pain, has symptom muscle pain, has symptom vomiting, has symptom shock, and has symptom bleeding.
PMOID: PMO:00029380
Subclass_of: viral infectious disease
Synonym: Chapare haemorrhagic fever
Synonym: Haemorrhagic fever caused by Chapare virus
Synonym: Hemorrhagic fever caused by Chapare virus
Synonym: Hemorrhagic fever caused by Chapare virus (disorder)
Tree Number: T10.7.2.30
database_cross_reference: DO:DOID:0050198
database_cross_reference: SNOMEDCT_US:716584007

Whitewater Arroyo hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Whitewater Arroyo virus, which is transmitted_by white-throated woodrats (Neotoma albigula). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, and has_symptom hemorrhagic manifestations.
PMOID: PMO:00029359
Subclass_of: viral infectious disease
Tree Number: T10.7.2.12
database_cross_reference: DO:DOID:0050199

Korean hemorrhagic fever
type: Class
subclass of: hemorrhagic fever with renal syndrome
definition: A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.
PMOID: PMO:00029389
Subclass_of: hemorrhagic fever with renal syndrome
Synonym: Epidemic Hemorrhagic Fever
Synonym: Epidemic Hemorrhagic Fevers
Synonym: Epidemic haemorrhagic fever
Synonym: Epidemic hemorrhagic fever
Synonym: HEMORRHAGIC FEVER WITH RENAL SYNDROME
Synonym: HEMORRHAGIC FEVER, EPIDEMIC
Synonym: HFRS
Synonym: HFRS (hemorrhagic fever with renal syndrome)
Synonym: HFRS - Haem fever & renal synd
Synonym: HFRS - Haemorrhagic fever with renal syndrome
Tree Number: T10.7.2.34.2
database_cross_reference: CHV:0000006017
database_cross_reference: DO:DOID:0050200
database_cross_reference: DO:DOID:11266
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000803
database_cross_reference: ICD10:A98.5
database_cross_reference: ICD10AM:A98.5
database_cross_reference: ICD10AMAE:A98.5
database_cross_reference: ICD10CM:A98.5
database_cross_reference: ICD9CM:078.6
database_cross_reference: LCH_NW:sh91003558
database_cross_reference: MDR:10019015
database_cross_reference: MDR:10019142
database_cross_reference: MDR:10019606
database_cross_reference: MDR:10023484
database_cross_reference: MDR:10055301
database_cross_reference: MDR:10062539
database_cross_reference: MDR:10075015
database_cross_reference: MDR:10075020
database_cross_reference: MEDCIN:350206
database_cross_reference: MEDCIN:36174
database_cross_reference: MSH:D006480
database_cross_reference: MTHICD9:078.6
database_cross_reference: NCI:C84753
database_cross_reference: NDFRT:N0000001489
database_cross_reference: RCD:A786.
database_cross_reference: RCDAE:A786.
database_cross_reference: SNM:D-0818
database_cross_reference: SNM:D-6735
database_cross_reference: SNMI:DE-34910
database_cross_reference: SNOMEDCT_US:102455002
database_cross_reference: SNOMEDCT_US:186701001
database_cross_reference: SNOMEDCT_US:364756009
database_cross_reference: SNOMEDCT_US:70826003
database_cross_reference: SNOMEDCT_US:716864001

nephropathia epidemica
type: Class
subclass of: hemorrhagic fever with renal syndrome
definition: An interstitial nephritis endemic to the regions along the Danube river, in the modern countries of Croatia, Bosnia and Herzegovina, Serbia, Romania and Bulgaria.
PMOID: PMO:00029388
Subclass_of: hemorrhagic fever with renal syndrome
Synonym: BALKAN ENDEMIC NEPHROPATHY
Synonym: BEN
Synonym: Balkan Endemic Nephropathy
Synonym: Balkan Nephropathy
Synonym: Balkan Nephropathy [Disease/Finding]
Synonym: Balkan endemic nephropathy
Synonym: Balkan nephritis syndrome
Synonym: Balkan nephropathy
Synonym: Balkan nephropathy (diagnosis)
Synonym: Balkan nephropathy (disorder)
Tree Number: T10.7.2.34.1
database_cross_reference: DO:DOID:3052
database_cross_reference: ICD10:N15.0
database_cross_reference: ICD10AM:N15.0
database_cross_reference: ICD10CM:N15.0
database_cross_reference: LCH_NW:sh87007105
database_cross_reference: MEDCIN:30689
database_cross_reference: MSH:D001449
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000529
database_cross_reference: OMIM:124100
database_cross_reference: RCD:X30JY
database_cross_reference: SNM:D-6734
database_cross_reference: SNMI:D7-12530
database_cross_reference: SNOMEDCT_US:197748005
database_cross_reference: SNOMEDCT_US:26121002

lujo hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection, has_material_basis_in Lujo virus, which has_symptom bleeding.
PMOID: PMO:00029393
Subclass_of: viral infectious disease
Synonym: Haemorrhagic fever caused by Lujo virus
Synonym: Hemorrhagic fever caused by Lujo virus
Synonym: Hemorrhagic fever caused by Lujo virus (disorder)
Synonym: Lujo haemorrhagic fever
Synonym: Lujo hemorrhagic fever
Synonym: Zambian haemorrhagic fever
Synonym: Zambian hemorrhagic fever
Tree Number: T10.7.2.37
database_cross_reference: DO:DOID:0050202
database_cross_reference: SNOMEDCT_US:716585008

Epstein-Barr virus hepatitis
type: Class
subclass of: viral hepatitis
definition: A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.
PMOID: PMO:00029419
Subclass_of: viral hepatitis
Synonym: EBV - Epstein-Barr virus hepatitis
Synonym: EBV hepatitis
Synonym: Epstein-Barr hepatitis
Synonym: Epstein-Barr virus hepatitis (disorder)
Synonym: ebv hepatitis
Synonym: hepatitis Epstein-Barr
Synonym: hepatitis due to EBV
Synonym: hepatitis due to Epstein-Barr virus
Synonym: hepatitis due to Epstein-Barr virus (diagnosis)
Synonym: hepatitis ebv
Tree Number: T10.7.2.53.1
database_cross_reference: CHV:0000039142
database_cross_reference: DO:DOID:0050204
database_cross_reference: MDR:10014076
database_cross_reference: MEDCIN:34870
database_cross_reference: RCD:Xa9C8
database_cross_reference: SNOMEDCT_US:302919001

swine influenza
type: Class
subclass of: influenza
definition: An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.
PMOID: PMO:00029414
Subclass_of: influenza
Tree Number: T10.7.2.50.1
database_cross_reference: DO:DOID:0050211

primary amebic meningoencephalitis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.
PMOID: PMO:00029679
Subclass_of: parasitic protozoa infectious disease
Synonym: MENINGOENCEPHALITIS, PRIMARY AMEBIC
Synonym: Naegleria fowleri infection
Synonym: Primary amebic meningoencephalitis
Synonym: Primary amoebic meningoencephalitis
Tree Number: T10.7.4.2.1
database_cross_reference: CSP:2214-5834
database_cross_reference: DO:DOID:0050242
database_cross_reference: DXP:U001166
database_cross_reference: ICD10CM:B60.2
database_cross_reference: SNM:D-0738
database_cross_reference: SNMI:DE-52600
database_cross_reference: SNOMEDCT_US:49649001

granulomatous amebic encephalitis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death.
PMOID: PMO:00029694
Subclass_of: parasitic protozoa infectious disease
Synonym: Acanthamoeba encephalitis
Synonym: Acanthamoeba granulomatous encephalitis
Synonym: GAE - Gran amoeb encephalomyel
Synonym: GAE - Granulomatous amebic encephalomyelitis
Synonym: GAE - Granulomatous amoebic encephalomyelitis
Synonym: Gran amebic encephalomyelitis
Synonym: Gran amoebic encephalomyelitis
Synonym: Granulomatous Amebic Encephalitis due to Acanthamoeba
Synonym: Granulomatous amebic encephal
Synonym: Granulomatous amebic encephalitis
Tree Number: T10.7.4.2.8
database_cross_reference: DO:DOID:0050246
database_cross_reference: RCD:X001N
database_cross_reference: RCDAE:X001N
database_cross_reference: SNOMEDCT_US:230187000

philophthalmiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the eyes by Philophthalmus species. External ocular philophthalmiasis manifests as follicular conjunctivitis and superficial keratitis. Sub-conjunctival ocular philophthalmiasis consists of a mild edema with minimal cellular reaction.
PMOID: PMO:00029627
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.10
database_cross_reference: DO:DOID:0050250

coenurosis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection by metacestode larval stage (coenurus) of Taenia multiceps or Taenia serialis. Coenuri in the skin or subcutaneous tissue present as painless nodules, which manifest on the trunk, sclera, subconjuctiva, neck, shoulders, head and limbs. Coenuri in the central nervous system may cause headache, fever, vomiting, nerve palsies, jacksonian epilepsy, pachymeningitis, obstructive or communicating hydrocephalus, and intracranial arteritis with transient hemiparesis. Coenuri in the eye cause both intraocular and orbital infections.
PMOID: PMO:00029665
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.33
database_cross_reference: DO:DOID:0050251

mesocestoidiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting.
PMOID: PMO:00029622
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.5
database_cross_reference: DO:DOID:0050253

acanthocephaliasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.
PMOID: PMO:00029672
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Acanthocephaliasis
Tree Number: T10.7.4.1.37
database_cross_reference: DO:DOID:0050254
database_cross_reference: ICD10CM:B83.8

angiostrongyliasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis.
PMOID: PMO:00029676
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.41
database_cross_reference: DO:DOID:0050256

baylisascariasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death.
PMOID: PMO:00029658
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.29
database_cross_reference: DO:DOID:0050259

dioctophymiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection by the nematode Dioctophyme renale in humans after eating undercooked food. The larvae are found in the subcutaneous nodules and kidneys.
PMOID: PMO:00029637
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.15
database_cross_reference: DO:DOID:0050260

thelaziasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious diseasea that involves infection of the eyes in humans by nematode Thelazia callipaeda causing varying degrees of inflammation and lacrimation. In heavier infections, photophobia, edema, conjunctivitis, and blindness occurs.
PMOID: PMO:00029675
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.40
database_cross_reference: DO:DOID:0050261

tungiasis
type: Class
subclass of: parasitic ectoparasitic infectious disease
definition: A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.
PMOID: PMO:00029730
Subclass_of: parasitic ectoparasitic infectious disease
Tree Number: T10.7.4.4.6
database_cross_reference: DO:DOID:0050266

basidiobolomycosis
type: Class
subclass of: subcutaneous mycosis
definition: A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.
PMOID: PMO:00029310
Subclass_of: subcutaneous mycosis
Synonym: Basidiobolomycosis
Synonym: Infection by Basidiobolus
Synonym: Infection by Basidiobolus (disorder)
Synonym: Infection by Basidiobolus, NOS
Synonym: Infection caused by Basidiobolus
Synonym: Infection caused by Basidiobolus (disorder)
Tree Number: T10.7.1.3.3
database_cross_reference: CHV:0000030898
database_cross_reference: DO:DOID:0050278
database_cross_reference: RCD:X70SN
database_cross_reference: SNMI:DE-43322
database_cross_reference: SNOMEDCT_US:4921002

conidiobolomycosis
type: Class
subclass of: subcutaneous mycosis
definition: An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions.
PMOID: PMO:00029309
Subclass_of: subcutaneous mycosis
Synonym: Conidiobolomycosis
Synonym: Conidiobolomycosis (disorder)
Synonym: Infection by Conidiobolus
Synonym: Infection by Conidiobolus (disorder)
Synonym: Infection by Conidiobolus (disorder) [Ambiguous]
Synonym: Infection by Conidiobolus, NOS
Synonym: Rhinoentomophthoromycosis
Tree Number: T10.7.1.3.2
database_cross_reference: DO:DOID:0050279
database_cross_reference: RCD:X70SK
database_cross_reference: SNMI:DE-43323
database_cross_reference: SNOMEDCT_US:240783007
database_cross_reference: SNOMEDCT_US:25785005

parasitic Ichthyosporea infectious disease
type: Class
subclass of: parasitic infectious disease
definition: A parasitic infectious disease that involves parasitic infection by the members of the class Ichthyosporea, which are parasites of fish and other animals.
PMOID: PMO:00029712
Subclass_of: parasitic infectious disease
Tree Number: T10.7.4.3
database_cross_reference: DO:DOID:0050291

primary systemic mycosis
type: Class
subclass of: systemic mycosis
definition: A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.
PMOID: PMO:00029335
Subclass_of: systemic mycosis
Tree Number: T10.7.1.4.2
database_cross_reference: DO:DOID:0050292

Alkhurma hemorrhagic fever
type: Class
subclass of: Kyasanur forest disease
definition: A viral infectious disease that is a hemorrhagic fever, has material basis in Alkhurma hemorrhagic fever virus, which is transmitted by Ornithodoros savignyi tick bite, transmitted by ingestion of unpasteurized camel milk, or transmitted by entry via skin wound. The infection has symptom headache, has symptom joint pain, has symptom muscle pain, has symptom vomiting, has symptom thrombocytopenia, and has symptom hemorrhagic fever.
PMOID: PMO:00029400
Subclass_of: Kyasanur forest disease
Tree Number: T10.7.2.43.1
database_cross_reference: DO:DOID:0050308

primary bacterial infectious disease
type: Class
subclass of: bacterial infectious disease
definition: A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.
PMOID: PMO:00029459
Subclass_of: bacterial infectious disease
Tree Number: T10.7.3.1
database_cross_reference: DO:DOID:0050338

commensal bacterial infectious disease
type: Class
subclass of: bacterial infectious disease
definition: A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder.
PMOID: PMO:00029599
Subclass_of: bacterial infectious disease
Tree Number: T10.7.3.3
database_cross_reference: DO:DOID:0050339

opportunistic bacterial infectious disease
type: Class
subclass of: bacterial infectious disease
definition: A bacterial infectious disease that results_in infection by bacteria in individuals whose host defense mechanisms have been compromised.
PMOID: PMO:00029613
Subclass_of: bacterial infectious disease
Tree Number: T10.7.3.5
database_cross_reference: DO:DOID:0050340

restless legs syndrome
type: Class
subclass of: central nervous system disease
definition: A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them.
PMOID: PMO:00030483
Subclass_of: central nervous system disease
Synonym: Disease, Willis Ekbom
Synonym: Disease, Willis-Ekbom
Synonym: Ekbom syndrome
Synonym: LEGS RESTLESS
Synonym: Legs restless
Synonym: RESTLESS LEG SYNDROME
Synonym: RESTLESS LEGS
Synonym: RLS
Synonym: Restless Leg Syndrome
Synonym: Restless Legs
Tree Number: T10.8.2.9.8
database_cross_reference: CCPSS:0041911
database_cross_reference: CHV:0000010777
database_cross_reference: COSTAR:U000591
database_cross_reference: CSP:5006-0032
database_cross_reference: CST:HYPERKINESIA
database_cross_reference: DO:DOID:0050425
database_cross_reference: DSM-5:333.94
database_cross_reference: DSM-5:G25.81
database_cross_reference: HPO:HP:0012452
database_cross_reference: ICD10CM:G25.81
database_cross_reference: ICD9CM:333.94
database_cross_reference: ICPC2EENG:N04
database_cross_reference: ICPC2P:N04001
database_cross_reference: LCH_NW:sh96010873
database_cross_reference: MDR:10024183
database_cross_reference: MDR:10038741
database_cross_reference: MDR:10038742
database_cross_reference: MDR:10042841
database_cross_reference: MDR:10058920
database_cross_reference: MEDCIN:35827
database_cross_reference: MEDLINEPLUS:384
database_cross_reference: MSH:D012148
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84501
database_cross_reference: NCI_NCI-GLOSS:CDR0000662021
database_cross_reference: NCI_NCI-GLOSS:CDR0000662022
database_cross_reference: NCI_NICHD:C84501
database_cross_reference: NDFRT:N0000002605
database_cross_reference: RCD:F13z2
database_cross_reference: SNM:D-8218
database_cross_reference: SNMI:DA-21152
database_cross_reference: SNOMEDCT_US:32914008
database_cross_reference: SNOMEDCT_US:393579008

Stevens-Johnson syndrome
type: Class
subclass of: skin disease
PMOID: PMO:00033877
Subclass_of: skin disease
Synonym: Antibiotic necrolysis
Synonym: EPIDERMAL NECROLYSIS TOX
Synonym: EPIDERMOLYSIS, ACUTE TOXIC
Synonym: Epidermal Necrolyses, Toxic
Synonym: Epidermal Necrolysis, Toxic
Synonym: LYELL SYNDROME
Synonym: LYELL'S SYNDROME
Synonym: Leyell's syndrome
Synonym: Lyell
Synonym: Lyell Syndrome
Tree Number: T10.8.12.2.14
database_cross_reference: CCPSS:1012555
database_cross_reference: CHV:0000004545
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2716-6757
database_cross_reference: CST:EPIDERM NECRO
database_cross_reference: DO:DOID:0050426
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001260
database_cross_reference: ICD10:L51.2
database_cross_reference: ICD10AM:L51.2
database_cross_reference: ICD10CM:L51.2
database_cross_reference: ICD9CM:695.15
database_cross_reference: LCH:U004730
database_cross_reference: LCH_NW:sh85136322
database_cross_reference: MDR:10025165
database_cross_reference: MDR:10025166
database_cross_reference: MDR:10025167
database_cross_reference: MDR:10025168
database_cross_reference: MDR:10028849
database_cross_reference: MDR:10042821
database_cross_reference: MDR:10043221
database_cross_reference: MDR:10044222
database_cross_reference: MDR:10044223
database_cross_reference: MEDCIN:34854
database_cross_reference: MSH:D013262
database_cross_reference: MTH:U001893
database_cross_reference: MTHICD9:695.15
database_cross_reference: NCI:C79777
database_cross_reference: NCI_CTCAE:E13743
database_cross_reference: NCI_NICHD:C79777
database_cross_reference: RCD:M1518
database_cross_reference: SNM:M-48620
database_cross_reference: SNMI:D0-10455
database_cross_reference: SNOMEDCT_US:156362004
database_cross_reference: SNOMEDCT_US:200919006
database_cross_reference: SNOMEDCT_US:23067006
database_cross_reference: SNOMEDCT_US:267848009
database_cross_reference: SNOMEDCT_VET:311031000009104

Danon disease
type: Class
subclass of: lysosomal storage disease
PMOID: PMO:00029115
Subclass_of: lysosomal storage disease
Synonym: ANTOPOL DISEASE
Synonym: Antopol Disease
Synonym: Cardiomyopathies, Glycogen Storage
Synonym: Cardiomyopathy, Glycogen Storage
Synonym: DANON DISEASE
Synonym: Danon Disease
Synonym: Danon disease (diagnosis)
Synonym: Danon disease (disorder)
Synonym: Disease, Antopol
Synonym: GLYCOGEN STORAGE DISEASE IIb
Tree Number: T10.6.2.8.12
database_cross_reference: DO:DOID:0050437
database_cross_reference: MDR:10071756
database_cross_reference: MEDCIN:350445
database_cross_reference: MSH:D052120
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84735
database_cross_reference: NDFRT:N0000171678
database_cross_reference: OMIM:300257
database_cross_reference: OMIM:309060
database_cross_reference: SNOMEDCT_US:419097006

infantile Refsum disease
type: Class
subclass of: peroxisomal disease
PMOID: PMO:00029239
Subclass_of: peroxisomal disease
Synonym: ADRENOLEUKODYSTROPHY, AUTOSOMAL NEONATAL
Synonym: Disease, Infantile Refsum
Synonym: Disease, Infantile Refsum's
Synonym: INFANTILE PHYTANIC ACID STORAGE DIS
Synonym: INFANTILE PHYTANIC ACID STORAGE DISEASE
Synonym: INFANTILE REFSUM DIS
Synonym: INFANTILE REFSUMS DIS
Synonym: Infantile Form of Phytanic Acid Storage Disease
Synonym: Infantile Phytanic Acid Storage Disease
Synonym: Infantile Refsum Disease
Tree Number: T10.6.2.16.2
database_cross_reference: CHV:0000027631
database_cross_reference: DO:DOID:0050444
database_cross_reference: ICD10CM:G60.1
database_cross_reference: MEDCIN:312738
database_cross_reference: MSH:D052919
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84789
database_cross_reference: NDFRT:N0000181119
database_cross_reference: OMIM:601539
database_cross_reference: OMIM:602136
database_cross_reference: RCD:X40Wh
database_cross_reference: SNOMEDCT_US:238062008

hereditary mucosal leukokeratosis
type: Class
subclass of: skin disease
definition: A skin disease characterized by a defect in the normal process of keratinization of the mucosa.
PMOID: PMO:00033960
Subclass_of: skin disease
Synonym: Keratosis, Oral
Synonym: LEUKOPLAKIA OF MOUTH
Synonym: LEUKOPLAKIA ORAL
Synonym: Leucoplakia of oral mucosa
Synonym: Leucoplakia of oral mucosa, NOS
Synonym: Leukokeratoses, Oral
Synonym: Leukokeratosis of Oral Mucosa
Synonym: Leukokeratosis of oral mucosa
Synonym: Leukokeratosis, Oral
Synonym: Leukoplakia buccalis
Tree Number: T10.8.12.2.40
database_cross_reference: AOD:0000005475
database_cross_reference: CCPSS:0004967
database_cross_reference: CHV:0000007370
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2139-2668
database_cross_reference: CST:LEUKOPLAKIA ORAL
database_cross_reference: DO:DOID:0050448
database_cross_reference: HPO:HP:0002745
database_cross_reference: ICD10CM:K13.21
database_cross_reference: ICPC2P:D83022
database_cross_reference: LCH:U002672
database_cross_reference: LCH_NW:sh85076301
database_cross_reference: MDR:10024392
database_cross_reference: MDR:10024396
database_cross_reference: MDR:10024398
database_cross_reference: MDR:10030982
database_cross_reference: MDR:10052579
database_cross_reference: MEDCIN:30800
database_cross_reference: MSH:D007972
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3187
database_cross_reference: NCI:C36262
database_cross_reference: NDFRT:N0000001840
database_cross_reference: OMIM:MTHU017607
database_cross_reference: OMIM:MTHU023979
database_cross_reference: PDQ:CDR0000422412
database_cross_reference: RCD:J086.
database_cross_reference: RCD:J086z
database_cross_reference: SNMI:D5-21500
database_cross_reference: SNOMEDCT_US:155663006
database_cross_reference: SNOMEDCT_US:196564008
database_cross_reference: SNOMEDCT_US:196570002
database_cross_reference: SNOMEDCT_US:414603003
database_cross_reference: SNOMEDCT_US:62953009

mevalonic aciduria
type: Class
subclass of: peroxisomal disease
PMOID: PMO:00029243
Subclass_of: peroxisomal disease
Synonym: Deficiency of mevalonate kinase
Synonym: Deficiency of mevalonate kinase (disorder)
Synonym: HIDS
Synonym: Hyperimmunoglobulin D with Periodic Fever Syndrome
Synonym: Kinase Deficiencies, Mevalonate
Synonym: Kinase Deficiency, Mevalonate
Synonym: MKD
Synonym: Mevalonate Kinase Deficiencies
Synonym: Mevalonate Kinase Deficiency
Synonym: Mevalonate Kinase Deficiency [Disease/Finding]
Tree Number: T10.6.2.16.6
database_cross_reference: DO:DOID:0050452
database_cross_reference: ICD10CM:M04.1
database_cross_reference: MDR:10072221
database_cross_reference: MSH:D054078
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84890
database_cross_reference: NCI_NICHD:C84890
database_cross_reference: NDFRT:N0000181132
database_cross_reference: RCD:X40TA
database_cross_reference: SNOMEDCT_US:124327008

lissencephaly
type: Class
subclass of: congenital nervous system abnormality
definition: A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation.
PMOID: PMO:00028241
Subclass_of: congenital nervous system abnormality
Synonym: Lissencephalia
Synonym: Lissencephalies
Synonym: Lissencephaly
Synonym: Lissencephaly (disorder)
Synonym: Lissencephaly [Disease/Finding]
Synonym: Lissencephaly pachygyria
Synonym: Pachygyria/lissencephaly
Synonym: lissencephaly (diagnosis)
Tree Number: T10.4.1.4
database_cross_reference: CHV:0000026051
database_cross_reference: DO:DOID:0050453
database_cross_reference: HPO:HP:0001339
database_cross_reference: ICD10CM:Q04.3
database_cross_reference: LCH_NW:sh00010142
database_cross_reference: MDR:10048911
database_cross_reference: MEDCIN:218978
database_cross_reference: MSH:D054082
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C103921
database_cross_reference: NCI_NICHD:C103921
database_cross_reference: NDFRT:N0000181090
database_cross_reference: OMIM:MTHU037613
database_cross_reference: OMIM:MTHU050742
database_cross_reference: RCD:P223.
database_cross_reference: SNM:M-25440
database_cross_reference: SNOMEDCT_US:204036008

periventricular nodular heterotopia
type: Class
subclass of: congenital nervous system abnormality
definition: A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain.
PMOID: PMO:00028238
Subclass_of: congenital nervous system abnormality
Synonym: BPNH
Synonym: Bilateral Periventricular Nodular Heterotopia
Synonym: Familial Nodular Heterotopia
Synonym: Familial Nodular Heterotopias
Synonym: HETEROTOPIA, FAMILIAL NODULAR
Synonym: HETEROTOPIA, PERIVENTRICULAR NODULAR, 1
Synonym: HETEROTOPIA, PERIVENTRICULAR, X-LINKED DOMINANT
Synonym: Heterotopia, Familial Nodular
Synonym: Heterotopia, Periventricular, X-Linked Dominant
Synonym: Heterotopia, X-Linked Periventricular
Tree Number: T10.4.1.1
database_cross_reference: DO:DOID:0050454
database_cross_reference: MSH:D054091
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300017
database_cross_reference: OMIM:300049
database_cross_reference: SNOMEDCT_US:448227009

Buruli ulcer disease
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin.
PMOID: PMO:00029488
Subclass_of: primary bacterial infectious disease
Synonym: BURULI ULCER
Synonym: Bairnsdale ulcer
Synonym: Buruli Ulcer
Synonym: Buruli Ulcer Disease
Synonym: Buruli Ulcer Diseases
Synonym: Buruli Ulcer [Disease/Finding]
Synonym: Buruli ulcer
Synonym: Buruli ulcer (diagnosis)
Synonym: Buruli ulcer (disorder)
Synonym: Cutaneous mycobacterium ulcerans infection
Tree Number: T10.7.3.1.7
database_cross_reference: CHV:0000015658
database_cross_reference: DO:DOID:0050456
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000273
database_cross_reference: ICD10CM:A31.1
database_cross_reference: MDR:10066289
database_cross_reference: MDR:10066290
database_cross_reference: MEDCIN:36245
database_cross_reference: MEDCIN:37141
database_cross_reference: MSH:D054312
database_cross_reference: MTHICD9:031.1
database_cross_reference: NCI:C84604
database_cross_reference: NDFRT:N0000181040
database_cross_reference: RCD:X70Hy
database_cross_reference: SNM:D-0149
database_cross_reference: SNMI:DE-12931
database_cross_reference: SNOMEDCT_US:15845006
database_cross_reference: SNOMEDCT_US:186343005

Wolf-Hirschhorn syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028808
Subclass_of: chromosomal deletion syndrome
Synonym: 4p deletion syndrome
Synonym: Mental Retardation, Unusual Facies, And Intrauterine Growth Retardation
Synonym: PITT SYNDROME
Synonym: PITT-ROGERS-DANKS SYNDROME
Synonym: PRDS
Synonym: Pitt Rogers Danks Syndrome
Synonym: Pitt Syndrome
Synonym: Pitt Syndromes
Synonym: Pitt syndrome
Synonym: Pitt-Rogers-Danks Syndrome
Tree Number: T10.5.9.8.31
database_cross_reference: CHV:0000048960
database_cross_reference: DO:DOID:0050460
database_cross_reference: JABL:531
database_cross_reference: MSH:D054877
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:194190

aspartylglucosaminuria
type: Class
subclass of: lysosomal storage disease
PMOID: PMO:00029110
Subclass_of: lysosomal storage disease
Synonym: AGA DEFICIENCY
Synonym: AGA Deficiencies
Synonym: AGA Deficiency
Synonym: AGU
Synonym: ASPARTYLGLUCOSAMINIDASE DEFICIENCY
Synonym: ASPARTYLGLUCOSAMINURIA
Synonym: ASPARTYLGLYCOSAMINURIA
Synonym: Aspartylglucosamidase Deficiencies
Synonym: Aspartylglucosamidase Deficiency
Synonym: Aspartylglucosaminidase deficiency
Tree Number: T10.6.2.8.7
database_cross_reference: CHV:0000026275
database_cross_reference: DO:DOID:0050461
database_cross_reference: HPO:HP:0012068
database_cross_reference: ICD10CM:E77.1
database_cross_reference: JABL:41
database_cross_reference: LCH_NW:sh85008693
database_cross_reference: LCH_NW:sh94002845
database_cross_reference: MDR:10068220
database_cross_reference: MSH:D054880
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C61273
database_cross_reference: NDFRT:N0000181095
database_cross_reference: OMIM:208400
database_cross_reference: OMIM:613228
database_cross_reference: OMIM:MTHU014368
database_cross_reference: RCD:C31y7
database_cross_reference: SNM:D-1728
database_cross_reference: SNMI:D6-72500
database_cross_reference: SNOMEDCT_US:54954004

erythrokeratodermia variabilis
type: Class
subclass of: skin disease
PMOID: PMO:00033858
Subclass_of: skin disease
Synonym: Congenital poikiloderma
Synonym: EKV
Synonym: EKVP
Synonym: ERYTHROKERATODERMIA FIGURATA, CONGENITAL FAMILIAL, IN PLAQUES
Synonym: ERYTHROKERATODERMIA VARIABILIS
Synonym: ERYTHROKERATODERMIA VARIABILIS ET PROGRESSIVA
Synonym: ERYTHROKERATODERMIA VARIABILIS WITH ERYTHEMA GYRATUM REPENS
Synonym: ERYTHROKERATODERMIA, PROGRESSIVE SYMMETRIC
Synonym: Erythro et Keratodermia Variabilis
Synonym: Erythrokeratoderma variabilis
Tree Number: T10.8.12.2.8
database_cross_reference: DO:DOID:0050467
database_cross_reference: MDR:10049048
database_cross_reference: MSH:D056266
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84696
database_cross_reference: NDFRT:N0000181088
database_cross_reference: OMIM:121014
database_cross_reference: OMIM:133200
database_cross_reference: OMIM:603324
database_cross_reference: OMIM:605425
database_cross_reference: RCD:X50IQ
database_cross_reference: SNMI:D4-40116
database_cross_reference: SNOMEDCT_US:254184006
database_cross_reference: SNOMEDCT_US:70041004

yellow nail syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached.
PMOID: PMO:00025186
Subclass_of: syndrome
Synonym: Hereditary lymphedema and yellow nails
Synonym: Hereditary lymphedema and yellow nails (disorder)
Synonym: Hereditary lymphoedema and yellow nails
Synonym: LYMPHEDEMA AND YELLOW NAILS
Synonym: Lymphedema And Yellow Nails
Synonym: Nail Syndrome, Yellow
Synonym: Nail Syndromes, Yellow
Synonym: Syndrome, Yellow Nail
Synonym: Syndromes, Yellow Nail
Synonym: YELLOW NAIL SYNDROME
Tree Number: T10.1.67
database_cross_reference: CHV:0000021398
database_cross_reference: DO:DOID:0050468
database_cross_reference: ICD10:L60.5
database_cross_reference: ICD10AM:L60.5
database_cross_reference: ICD10CM:L60.5
database_cross_reference: MDR:10048239
database_cross_reference: MDR:10048244
database_cross_reference: MEDCIN:37103
database_cross_reference: MSH:D056684
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85238
database_cross_reference: NDFRT:N0000181068
database_cross_reference: OMIM:153300
database_cross_reference: RCD:M23yE
database_cross_reference: SNM:M-04050
database_cross_reference: SNMI:D0-54172
database_cross_reference: SNOMEDCT_US:400211001
database_cross_reference: SNOMEDCT_US:45342007

Weill-Marchesani syndrome
type: Class
subclass of: autosomal genetic disease
definition: An autosomal genetic disease characterized by short stature, bachycephaly and other facial abnormalities, brachydactyly, joint stiffness and distinctive ocular abnormalities.
PMOID: PMO:00028503
Subclass_of: autosomal genetic disease
Synonym: Brachydactyly-spherophakia syndrome
Synonym: Brachymorphy with spherophakia syndrome
Synonym: Congenital Mesodermal Dysmorphodystrophies
Synonym: Congenital Mesodermal Dysmorphodystrophy
Synonym: Dysmorphodystrophies, Congenital Mesodermal
Synonym: Dysmorphodystrophy, Congenital Mesodermal
Synonym: GEMSS syndrome
Synonym: Marchesani Syndrome
Synonym: Marchesani Weill Syndrome
Synonym: Marchesani syndrome
Tree Number: T10.5.3.2.7
database_cross_reference: CHV:0000025887
database_cross_reference: DO:DOID:0050475
database_cross_reference: MDR:10064963
database_cross_reference: MEDCIN:38657
database_cross_reference: MSH:D056846
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85226
database_cross_reference: NDFRT:N0000181084
database_cross_reference: RCD:PKy56
database_cross_reference: SNM:D-5296
database_cross_reference: SNM:D-X432
database_cross_reference: SNMI:D4-00D13
database_cross_reference: SNOMEDCT_US:205801004
database_cross_reference: SNOMEDCT_US:2884008

Barth syndrome
type: Class
subclass of: lipid metabolism disorder
definition: A lipid metabolism disorder that has_material_basis_in X-linked inheritance of the tafazzin gene and is characterized by decreased production of an enzyme required to produce cardiolipin.
PMOID: PMO:00029278
Subclass_of: lipid metabolism disorder
Synonym: 3 Methylglutaconic Aciduria, Type II
Synonym: 3 Methylglutaconicaciduria Type 2
Synonym: 3-METHYLGLUTACONIC ACIDURIA, TYPE II
Synonym: 3-Methylglutac aciduria type 2
Synonym: 3-Methylglutaconic Aciduria Type 2
Synonym: 3-Methylglutaconic Aciduria, Type II
Synonym: 3-Methylglutaconic aciduria type 2
Synonym: 3-Methylglutaconic aciduria type 2 (disorder)
Synonym: 3-Methylglutaconicaciduria Type 2
Synonym: 3-Methylglutaconicaciduria Type 2s
Tree Number: T10.6.2.18.9
database_cross_reference: CHV:0000040198
database_cross_reference: DO:DOID:0050476
database_cross_reference: ICD10CM:E78.71
database_cross_reference: MDR:10078537
database_cross_reference: MEDCIN:338072
database_cross_reference: MSH:D056889
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84585
database_cross_reference: NCI_NICHD:C84585
database_cross_reference: NDFRT:N0000181162
database_cross_reference: OMIM:300394
database_cross_reference: OMIM:302060
database_cross_reference: RCD:Xa6aY
database_cross_reference: SNOMEDCT_US:297231002

sennetsu fever
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.
PMOID: PMO:00029578
Subclass_of: primary bacterial infectious disease
Synonym: Human Ehrlichial infection, Sennetsu type
Synonym: Sennetsu Fever
Synonym: Sennetsu ehrlichiosis
Synonym: Sennetsu fever
Synonym: Sennetsu fever (disorder)
Tree Number: T10.7.3.1.34
database_cross_reference: DO:DOID:0050485
database_cross_reference: MSH:C537582
database_cross_reference: SNMI:DE-22778
database_cross_reference: SNOMEDCT_US:21013006

exanthem
type: Class
subclass of: skin disease
PMOID: PMO:00033789
Subclass_of: skin disease
Synonym: Breaking out - eruption
Synonym: Cutaneous Eruption
Synonym: Cutaneous eruption
Synonym: Cutaneous eruption (morphologic abnormality)
Synonym: Cutaneous eruption, NOS
Synonym: ERUPTION
Synonym: EXANTHEM
Synonym: Efflorescence
Synonym: Eruption
Synonym: Eruption (disorder)
Tree Number: T10.8.12.2.5
database_cross_reference: AOD:0000004377
database_cross_reference: AOD:0000022958
database_cross_reference: BI:BI00609
database_cross_reference: CCPSS:1014681
database_cross_reference: CHV:0000004754
database_cross_reference: CHV:0000029440
database_cross_reference: COSTAR:638
database_cross_reference: COSTAR:U000558
database_cross_reference: CST:RASH
database_cross_reference: CST:SKINRASH
database_cross_reference: DO:DOID:0050486
database_cross_reference: HPO:HP:0000988
database_cross_reference: ICD10:R21
database_cross_reference: ICD10AM:R21
database_cross_reference: ICD10CM:R21
database_cross_reference: ICD9CM:782.1
database_cross_reference: LCH:U001699
database_cross_reference: LCH_NW:sh85046091
database_cross_reference: LNC:LA7469-5
database_cross_reference: LNC:LP30547-1
database_cross_reference: LNC:MTHU015064
database_cross_reference: LNC:MTHU020933
database_cross_reference: MDR:10015585
database_cross_reference: MDR:10015587
database_cross_reference: MDR:10037844
database_cross_reference: MDR:10037845
database_cross_reference: MDR:10037849
database_cross_reference: MDR:10037872
database_cross_reference: MDR:10040841
database_cross_reference: MDR:10040913
database_cross_reference: MDR:10058692
database_cross_reference: MEDCIN:110670
database_cross_reference: MEDCIN:273176
database_cross_reference: MEDLINEPLUS:208
database_cross_reference: MSH:D005076
database_cross_reference: MTH:638
database_cross_reference: MTH:U003405
database_cross_reference: MTHICD9:782.1
database_cross_reference: NCI:C111884
database_cross_reference: NCI:C39594
database_cross_reference: NCI_FDA:2033
database_cross_reference: NCI_NICHD:C111884
database_cross_reference: NCI_NICHD:C39594
database_cross_reference: NDFRT:N0000001170
database_cross_reference: OMIM:MTHU008860
database_cross_reference: OMIM:MTHU011109
database_cross_reference: OMIM:MTHU047706
database_cross_reference: RCD:R021.
database_cross_reference: RCD:R0210
database_cross_reference: RCD:R021z
database_cross_reference: RCD:XM07J
database_cross_reference: RCDSY:R021.
database_cross_reference: RCDSY:R0210
database_cross_reference: RCDSY:R021z
database_cross_reference: SNM:M-01700
database_cross_reference: SNM:M-48400
database_cross_reference: SNM:U000256
database_cross_reference: SNMI:M-01710
database_cross_reference: SNOMEDCT_US:112625008
database_cross_reference: SNOMEDCT_US:139684003
database_cross_reference: SNOMEDCT_US:158230006
database_cross_reference: SNOMEDCT_US:158231005
database_cross_reference: SNOMEDCT_US:158234002
database_cross_reference: SNOMEDCT_US:1806006
database_cross_reference: SNOMEDCT_US:206860008

exanthema subitum
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.
PMOID: PMO:00029361
Subclass_of: viral infectious disease
Synonym: Disease, Sixth
Synonym: EXANTHEM SUBITUM
Synonym: Ecthyma contagiosum
Synonym: Ecthyma, Contagious
Synonym: Exanthem subitum
Synonym: Exanthema Subitum
Synonym: Exanthema Subitum [Disease/Finding]
Synonym: Exanthema subitum
Synonym: Exanthema subitum (disorder)
Synonym: Exanthema subitum [sixth disease]
Tree Number: T10.7.2.14
database_cross_reference: CHV:0000004755
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:0050495
database_cross_reference: DO:DOID:8771
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000610
database_cross_reference: ICD10:B08.2
database_cross_reference: ICD10AM:B08.2
database_cross_reference: ICD10CM:B08.2
database_cross_reference: ICD10CM:B08.20
database_cross_reference: ICD9CM:058.1
database_cross_reference: ICD9CM:058.10
database_cross_reference: ICPC2P:A76007
database_cross_reference: MDR:10015586
database_cross_reference: MDR:10039222
database_cross_reference: MDR:10039223
database_cross_reference: MDR:10050048
database_cross_reference: MEDCIN:31312
database_cross_reference: MSH:D005077
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:058.1
database_cross_reference: MTHICD9:058.10
database_cross_reference: NDFRT:N0000001171
database_cross_reference: RCD:A57y1
database_cross_reference: SNM:D-0393
database_cross_reference: SNMI:DE-38060
database_cross_reference: SNOMEDCT_US:154343004
database_cross_reference: SNOMEDCT_US:154344005
database_cross_reference: SNOMEDCT_US:240559001
database_cross_reference: SNOMEDCT_US:266192003
database_cross_reference: SNOMEDCT_US:266193008
database_cross_reference: SNOMEDCT_US:402902002
database_cross_reference: SNOMEDCT_US:54385001

variola major
type: Class
subclass of: smallpox
definition: A viral infectious disease that results in infection located in skin, has material basis in Variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. The infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.
PMOID: PMO:00029433
Subclass_of: smallpox
Synonym: Classical smallpox
Synonym: Ordinary smallpox
Synonym: SMALLPOX
Synonym: Small pox
Synonym: Smallpox
Synonym: Smallpox (disorder)
Synonym: Smallpox NOS
Synonym: Smallpox NOS (disorder)
Synonym: Smallpox [Disease/Finding]
Synonym: Smallpox, NOS
Tree Number: T10.7.2.66.1
database_cross_reference: CHV:0000011422
database_cross_reference: CSP:3100-0734
database_cross_reference: DO:DOID:8736
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001754
database_cross_reference: DXP:U003721
database_cross_reference: ICD10:B03
database_cross_reference: ICD10AM:B03
database_cross_reference: ICD10CM:B03
database_cross_reference: ICD9CM:050
database_cross_reference: ICD9CM:050.9
database_cross_reference: ICPC2P:A76008
database_cross_reference: LCH:U004344
database_cross_reference: LCH_NW:sh85123612
database_cross_reference: MDR:10041197
database_cross_reference: MDR:10041198
database_cross_reference: MEDCIN:31069
database_cross_reference: MEDLINEPLUS:1567
database_cross_reference: MSH:D012899
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35027
database_cross_reference: NCI_NICHD:C35027
database_cross_reference: NDFRT:N0000002776
database_cross_reference: RCD:A50..
database_cross_reference: RCD:A50z.
database_cross_reference: SNM:D-0478
database_cross_reference: SNMI:DE-31440
database_cross_reference: SNMI:DE-31441
database_cross_reference: SNOMEDCT_US:154344005
database_cross_reference: SNOMEDCT_US:186505008
database_cross_reference: SNOMEDCT_US:266193008
database_cross_reference: SNOMEDCT_US:47452006
database_cross_reference: SNOMEDCT_US:67924001

paralytic poliomyelitis
type: Class
subclass of: poliomyelitis
definition: A poliomyelitis that results in destruction located in motor neurons of central nervous system, has material basis in Human poliovirus 1, has material basis in Human poliovirus 2, or has material basis in Human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. The infection has symptom loss of reflexes, has symptom muscle spasms, and has symptom acute flaccid paralysis.
PMOID: PMO:00029407
Subclass_of: poliomyelitis
Synonym: Poliomyelitis, paralytic
Synonym: paralytic poliomyelitis (diagnosis)
Tree Number: T10.7.2.47.3
database_cross_reference: DO:DOID:0050515
database_cross_reference: LNC:LA10496-0
database_cross_reference: MEDCIN:36269

O'nyong'nyong fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in joint, has_material_basis_in O'nyong-nyong virus, which is transmitted_by Anopheles gambiae, and transmitted_by Anopheles funestus mosquitoes. The infection has_symptom fever, has_symptom arthralgia, has_symptom rash, and has_symptom lymphadenitis.
PMOID: PMO:00029442
Subclass_of: viral infectious disease
Tree Number: T10.7.2.73
database_cross_reference: DO:DOID:0050516

Barmah Forest virus disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in joint, has_material_basis_in Barmah Forest virus, which is transmitted_by mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.
PMOID: PMO:00029455
Subclass_of: viral infectious disease
Tree Number: T10.7.2.84
database_cross_reference: DO:DOID:0050517

Ross River fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in joint, has_material_basis_in Ross River virus, which is transmitted_by Culex, and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.
PMOID: PMO:00029379
Subclass_of: viral infectious disease
Synonym: Ross River virus disease
Tree Number: T10.7.2.29
database_cross_reference: DO:DOID:0050518

Oropouche fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection, has material basis in Oropouche virus, which is transmitted by biting midge, Culicoides paraensis. The infection has symptom fever, has symptom chills, has symptom headache, has symptom anorexia, has symptom muscle pain, has symptom joint pain, and has symptom vomiting.
PMOID: PMO:00029431
Subclass_of: viral infectious disease
Tree Number: T10.7.2.65
database_cross_reference: DO:DOID:0050521

Balkan hemorrhagic fever
type: Class
subclass of: hemorrhagic fever with renal syndrome
definition: A hemorrhagic fever with renal syndrome that results in infection located in kidney, has material basis in Dobrava-Belgrade virus , which is transmitted by yellow-necked field mouse, Apodemus flavicollis. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.
PMOID: PMO:00029390
Subclass_of: hemorrhagic fever with renal syndrome
Tree Number: T10.7.2.34.3
database_cross_reference: DO:DOID:0050522

maturity-onset diabetes of the young
type: Class
subclass of: genetic disease
definition: A genetic disease that has_material_basis_in mutations in the MODY genes disrupting insulin production.
PMOID: PMO:00028372
Subclass_of: genetic disease
Synonym: Autosomal dominant diabetes mellitus
Synonym: Diab mell aut dom
Synonym: Diabetes mellitus autosomal dominant
Synonym: Diabetes mellitus autosomal dominant (disorder)
Synonym: Diabetes, maturity-onset, of the young (MODY)
Synonym: MASON-TYPE DIABETES
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG
Synonym: MODY
Synonym: MODY - Maturity onset diabetes in youth type 1
Synonym: MODY - Maturity onset diabetes in youth type I
Tree Number: T10.5.2
database_cross_reference: CHV:0000030749
database_cross_reference: DO:DOID:0050524
database_cross_reference: HPO:HP:0004904
database_cross_reference: MDR:10026948
database_cross_reference: MEDCIN:358414
database_cross_reference: MSH:C562772
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C114769
database_cross_reference: OMIM:606391
database_cross_reference: OMIM:MTHU039842
database_cross_reference: RCD:X40JI
database_cross_reference: SNMI:DB-61040
database_cross_reference: SNOMEDCT_US:28453007
database_cross_reference: SNOMEDCT_US:390715006
database_cross_reference: SNOMEDCT_US:400971001
database_cross_reference: SNOMEDCT_US:609561005

Gamstorp-Wohlfart syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by progressive weakness and atrophy of muscles in feet, legs and hands. In some patients the syndrome also causes decreased sensitivity to touch, heat or cold, particularly in the lower arms or legs.
PMOID: PMO:00025139
Subclass_of: syndrome
Synonym: Autosomal recessive axonal neuropathy with neuromyotonia
Synonym: Autosomal recessive axonal neuropathy with neuromyotonia (disorder)
Synonym: Autosomal recessive neuromyotonia with axonal neuropathy
Synonym: Continuous Muscle Activity Syndrome
Synonym: Continuous Myokymia
Synonym: Continuous Myokymias
Synonym: Continuous muscle fiber activ
Synonym: Continuous muscle fiber activity
Synonym: Continuous muscle fiber activity syndrome
Synonym: Continuous muscle fibre activ
Tree Number: T10.1.25
database_cross_reference: CHV:0000024762
database_cross_reference: DO:DOID:0050526
database_cross_reference: DO:DOID:0050989
database_cross_reference: ICD10CM:G71.19
database_cross_reference: MDR:10072359
database_cross_reference: MDR:10072368
database_cross_reference: MDR:10072421
database_cross_reference: MEDCIN:32364
database_cross_reference: MSH:D020386
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000004130
database_cross_reference: OMIM:137200
database_cross_reference: OMIM:160120
database_cross_reference: OMIM:601314
database_cross_reference: OMIM:MTHU036768
database_cross_reference: RCD:X00CD
database_cross_reference: RCDAE:X00CD
database_cross_reference: SNM:D-8056
database_cross_reference: SNM:D-8841
database_cross_reference: SNMI:DA-51340
database_cross_reference: SNOMEDCT_US:230653006
database_cross_reference: SNOMEDCT_US:305719002
database_cross_reference: SNOMEDCT_US:711406009
database_cross_reference: SNOMEDCT_US:80138003

hypermethioninemia
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body.
PMOID: PMO:00029223
Subclass_of: amino acid metabolic disorder
Synonym: Deficiency of Methionine Adenosyltransferase
Synonym: Deficiency of methionine adenosyltransferase
Synonym: Deficiency of methionine adenosyltransferase (disorder)
Synonym: HYPERMETHIONINEMIA, ISOLATED PERSISTENT
Synonym: Hep methion adenosyltransf def
Synonym: Hepatic Methionine Adenosyltransferase Deficiency
Synonym: Hepatic methionine adenosyltransferase deficiency
Synonym: Hepatic methionine adenosyltransferase deficiency (disorder)
Synonym: Hepatic methionine adenosyltransferase deficiency [Ambiguous]
Synonym: Hypermethioninaemia
Tree Number: T10.6.2.15.25
database_cross_reference: CHV:0000026337
database_cross_reference: DO:DOID:0050544
database_cross_reference: HPO:HP:0003235
database_cross_reference: ICD10CM:E72.19
database_cross_reference: LNC:LA12512-2
database_cross_reference: MDR:10051245
database_cross_reference: MDR:10054414
database_cross_reference: MEDCIN:273554
database_cross_reference: MSH:C564683
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:270.4
database_cross_reference: NCI:C123435
database_cross_reference: OMIM:250850
database_cross_reference: OMIM:MTHU003943
database_cross_reference: OMIM:MTHU008949
database_cross_reference: RCD:XE11A
database_cross_reference: RCDAE:XE11A
database_cross_reference: SNM:D-1633
database_cross_reference: SNMI:D6-B4300
database_cross_reference: SNMI:D6-B4310
database_cross_reference: SNOMEDCT_US:124283007
database_cross_reference: SNOMEDCT_US:190708000
database_cross_reference: SNOMEDCT_US:267420003
database_cross_reference: SNOMEDCT_US:43123004
database_cross_reference: SNOMEDCT_US:57835009

visceral heterotaxy
type: Class
subclass of: physical disorder
PMOID: PMO:00028279
Subclass_of: physical disorder
Synonym: Ambiguus Viscerum, Situs
Synonym: Ambiguus Viscerums, Situs
Synonym: Ambiguus, Situs
Synonym: Heterotaxia
Synonym: Heterotaxies, Visceral
Synonym: Heterotaxis
Synonym: Heterotaxy
Synonym: Heterotaxy, Visceral
Synonym: Isomerism sequence
Synonym: Laterality sequence
Tree Number: T10.4.18
database_cross_reference: CHV:0000011378
database_cross_reference: HPO:HP:0001696
database_cross_reference: HPO:HP:0030853
database_cross_reference: JABL:341
database_cross_reference: MDR:10067265
database_cross_reference: MSH:D059446
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87083
database_cross_reference: NCI_NICHD:C87083
database_cross_reference: OMIM:MTHU043055
database_cross_reference: SNM:M-22120
database_cross_reference: SNMI:D4-01510
database_cross_reference: SNMI:D4-D0050
database_cross_reference: SNOMEDCT_US:14821001
database_cross_reference: SNOMEDCT_US:24614000

congenital adrenal insufficiency
type: Class
subclass of: adrenal gland disease
PMOID: PMO:00033242
Subclass_of: adrenal gland disease
Synonym: ADRENAL INSUFFICIENCY, CONGENITAL, WITH 46,XY SEX REVERSAL, PARTIAL OR COMPLETE
Synonym: P450scc DEFICIENCY
Tree Number: T10.8.8.6.5
database_cross_reference: DO:DOID:0050546
database_cross_reference: OMIM:118485
database_cross_reference: OMIM:613743

Saldino-Noonan syndrome
type: Class
subclass of: syndrome
definition: An asphyxiating thoracic dystrophy that has_material_basis_in homozygous or compound heterozygous mutation in the DYNC2H1 gene on chromosome 11q22.
PMOID: PMO:00025201
Subclass_of: syndrome
Synonym: ASPHYXIATING THORACIC DYSTROPHY 3
Synonym: ATD3
Synonym: Asphyxiating Thoracic Dystrophy 3
Synonym: POLYDACTYLY WITH NEONATAL CHONDRODYSTROPHY, TYPE I
Synonym: Polydactyly With Neonatal Chondrodystrophy, Type I
Synonym: Polydactyly with Neonatal Chondrodystrophy, Type 1
Synonym: SALDINO-NOONAN SYNDROME
Synonym: SHORT RIB-POLYDACTYLY SYNDROME, TYPE I
Synonym: SHORT RIB-POLYDACTYLY SYNDROME, TYPE IIB
Synonym: SHORT-RIB THORACIC DYSPLASIA 3 WITH OR WITHOUT POLYDACTYLY
Tree Number: T10.1.79
database_cross_reference: DO:DOID:0050549
database_cross_reference: DO:DOID:0110087
database_cross_reference: MSH:D012779
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:603297
database_cross_reference: OMIM:613091
database_cross_reference: RCD:XE2R5
database_cross_reference: SNMI:D4-00A33
database_cross_reference: SNOMEDCT_US:27330009

orofacial cleft
type: Class
subclass of: physical disorder
PMOID: PMO:00028284
Subclass_of: physical disorder
Synonym: CLEFT LIP WITH OR WITHOUT CLEFT PALATE, NONSYNDROMIC, 1
Synonym: CLEFT LIP/PALATE, NONSYNDROMIC
Synonym: Cleft Lip with or without Cleft Palate, Nonsyndromic, 1
Synonym: Cleft Lip-Palate, Nonsyndromic
Synonym: OFC
Synonym: OFC1
Synonym: OROFACIAL CLEFT 1
Synonym: OROFACIAL CLEFT, NONSYNDROMIC
Synonym: Orofacial Cleft 1
Synonym: Orofacial Cleft, Nonsyndromic
Tree Number: T10.4.21
database_cross_reference: DO:DOID:0050567
database_cross_reference: MSH:C566121
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124838
database_cross_reference: OMIM:119530

2-hydroxyglutaric aciduria
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that is an autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid causing progressive brain damage.
PMOID: PMO:00029227
Subclass_of: amino acid metabolic disorder
Synonym: 2-Hga
Synonym: 2-Hydroxyglutaric Aciduria
Synonym: 2-Hydroxyglutaricaciduria
Synonym: 2-hydroxyglutaric aciduria (disorder)
Synonym: COMBINED D-2- AND L-2 -HYDROXYGLUTARIC ACIDURIA
Synonym: COMBINED D-2- AND L-2-HYDROXYGLUTARIC ACIDURIA
Synonym: Combined D-2- and L-2-hydroxyglutaric aciduria
Synonym: D-2-hydroxyglutaric aciduria
Synonym: D2L2AD
Synonym: L-2-Hydroxyglutaric Acidemia
Tree Number: T10.6.2.15.26
database_cross_reference: DO:DOID:0050573
database_cross_reference: MSH:C535306
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C128187
database_cross_reference: OMIM:190315
database_cross_reference: OMIM:615182
database_cross_reference: SNOMEDCT_US:698870008

trichotillomania
type: Class
subclass of: impulse control disorder
definition: An impulse control disorder that involves the uncontrollable plucking of ones hair.
PMOID: PMO:00028135
Subclass_of: impulse control disorder
Synonym: Hair Pulling
Synonym: Hair plucking
Synonym: Hair pulling, chronic, compulsive, repetitive
Synonym: Hair-pulling
Synonym: TRICHOTILLOMANIA
Synonym: TTM
Synonym: Trichologia
Synonym: Trichotillomania
Synonym: Trichotillomania (disorder)
Synonym: Trichotillomania [Disease/Finding]
Tree Number: T10.3.7.3
database_cross_reference: AOD:0000006709
database_cross_reference: AOD:0000006741
database_cross_reference: CCPSS:0026790
database_cross_reference: CHV:0000012546
database_cross_reference: CSP:2483-7050
database_cross_reference: CSP:2716-0900
database_cross_reference: DO:DOID:0050587
database_cross_reference: HPO:HP:0012167
database_cross_reference: ICD10:F63.3
database_cross_reference: ICD10AM:F63.3
database_cross_reference: ICD10CM:F63.3
database_cross_reference: MDR:10019046
database_cross_reference: MDR:10044629
database_cross_reference: MEDCIN:1557
database_cross_reference: MEDCIN:35072
database_cross_reference: MEDLINEPLUS:6091
database_cross_reference: MSH:D014256
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:307.9
database_cross_reference: MTHICD9:312.39
database_cross_reference: NCI:C94336
database_cross_reference: NDFRT:N0000003013
database_cross_reference: OMIM:613229
database_cross_reference: OMIM:MTHU024464
database_cross_reference: PSY:22120
database_cross_reference: PSY:54225
database_cross_reference: RCD:Eu633
database_cross_reference: SNM:F-91510
database_cross_reference: SNMI:D9-75050
database_cross_reference: SNOMEDCT_US:17155009
database_cross_reference: SNOMEDCT_US:192032006

inflammatory bowel disease
type: Class
subclass of: intestinal disease
definition: An intestinal disease characterized by inflammation located_in all parts of digestive tract.
PMOID: PMO:00033547
Subclass_of: intestinal disease
Synonym: Autoimmune Bowel Disorder
Synonym: BOWEL DIS INFLAMM
Synonym: BOWEL INFLAMMATORY BOWEL DISEASE
Synonym: Bowel Diseases, Inflammatory
Synonym: Disease;inflammatory bowel
Synonym: IBD
Synonym: IBD - Inflam bowel disease
Synonym: IBD - Inflammatory bowel disease
Synonym: INFLAMM BOWEL DIS
Synonym: INFLAMMATORY BOWEL DISEASE
Tree Number: T10.8.11.8.11
database_cross_reference: AOD:0000005562
database_cross_reference: AOD:0000023377
database_cross_reference: BI:BI00276
database_cross_reference: CCPSS:0028015
database_cross_reference: CCPSS:0048225
database_cross_reference: CHV:0000006707
database_cross_reference: COSTAR:U000384
database_cross_reference: CSP:1248-5871
database_cross_reference: DO:DOID:0050589
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000955
database_cross_reference: HPO:HP:0002037
database_cross_reference: ICPC2P:D94009
database_cross_reference: LCH_NW:sh90000009
database_cross_reference: LNC:LA15162-3
database_cross_reference: LNC:LP36210-0
database_cross_reference: MDR:10021184
database_cross_reference: MDR:10021972
database_cross_reference: MDR:10021973
database_cross_reference: MEDCIN:359882
database_cross_reference: MEDLINEPLUS:119
database_cross_reference: MEDLINEPLUS:446
database_cross_reference: MSH:D015212
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3138
database_cross_reference: NCI_NCI-GLOSS:CDR0000045737
database_cross_reference: NCI_NICHD:C3138
database_cross_reference: NDFRT:N0000003206
database_cross_reference: OMIM:MTHU001680
database_cross_reference: RCD:XE0ae
database_cross_reference: SNM:D-6214
database_cross_reference: SNMI:D5-40990
database_cross_reference: SNOMEDCT_US:155759008
database_cross_reference: SNOMEDCT_US:196974002
database_cross_reference: SNOMEDCT_US:24526004
database_cross_reference: SNOMEDCT_US:266516008

taeniasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that has material basis in Taenia solium or has material basis in Taenia saginata, which are transmitted by ingestion of undercooked contaminated meat.
PMOID: PMO:00029634
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.13
database_cross_reference: DO:DOID:0050596

acrodermatitis enteropathica
type: Class
subclass of: metal metabolism disorder
PMOID: PMO:00029028
Subclass_of: metal metabolism disorder
Synonym: ACRODERMATITIS ENTEROPATHICA
Synonym: ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE
Synonym: AE - Acrodermat enteropathica
Synonym: AE - Acrodermatitis enteropathica
Synonym: AEZ
Synonym: Acrodermatitis Enteropathica
Synonym: Acrodermatitis Enteropathica, Zinc-Deficiency Type
Synonym: Acrodermatitis enteropathica
Synonym: Acrodermatitis enteropathica syndrome
Synonym: Acrodermatitis enteropathica zinc deficiency type
Tree Number: T10.6.2.4.6
database_cross_reference: CHV:0000021273
database_cross_reference: CSP:1849-0228
database_cross_reference: DO:DOID:0050605
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000029
database_cross_reference: ICD10CM:E83.2
database_cross_reference: MDR:10000596
database_cross_reference: MDR:10000597
database_cross_reference: MDR:10014903
database_cross_reference: MEDCIN:33635
database_cross_reference: MEDCIN:97970
database_cross_reference: MSH:C538178
database_cross_reference: NCI:C128802
database_cross_reference: OMIM:201100
database_cross_reference: OMIM:607059
database_cross_reference: RCD:X40QS
database_cross_reference: SNM:D-6225
database_cross_reference: SNMI:D6-38130
database_cross_reference: SNOMEDCT_US:37702000

oral cavity carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the oral cavity.
PMOID: PMO:00027313
Subclass_of: in situ carcinoma
Synonym: Ca in situ of oral cavity
Synonym: Cancer in situ of mouth
Synonym: Carcinoma in situ of Mouth
Synonym: Carcinoma in situ of Oral Cavity
Synonym: Carcinoma in situ of any part of mouth
Synonym: Carcinoma in situ of mouth
Synonym: Carcinoma in situ of mouth (disorder)
Synonym: Carcinoma in situ of mouth, NOS
Synonym: Carcinoma in situ of oral cavity
Synonym: Carcinoma in situ of the Mouth
Tree Number: T10.2.2.3.28
database_cross_reference: DO:DOID:0050610
database_cross_reference: MDR:10030965
database_cross_reference: MEDCIN:97906
database_cross_reference: MTHICD9:230.0
database_cross_reference: NCI:C4587
database_cross_reference: RCD:X78lH
database_cross_reference: SNMI:D5-F0502
database_cross_reference: SNOMEDCT_US:189210009
database_cross_reference: SNOMEDCT_US:92660005

pharynx carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the pharynx.
PMOID: PMO:00027292
Subclass_of: in situ carcinoma
Synonym: Cancer in situ of pharynx
Synonym: Carcinoma in situ of Pharynx
Synonym: Carcinoma in situ of pharynx
Synonym: Carcinoma in situ of pharynx (disorder)
Synonym: Carcinoma in situ of pharynx, NOS
Synonym: Carcinoma in situ of the Pharynx
Synonym: PHARYNGEAL CARCINOMA IN SITU
Synonym: Pharyngeal Cancer Stage 0
Synonym: Pharyngeal Carcinoma in situ
Synonym: Pharynx Carcinoma in situ
Tree Number: T10.2.2.3.11
database_cross_reference: CCPSS:0014024
database_cross_reference: DO:DOID:0050611
database_cross_reference: ICD10CM:D00.08
database_cross_reference: MEDCIN:97304
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4942
database_cross_reference: RCD:X78lt
database_cross_reference: SNMI:D2-F0402
database_cross_reference: SNOMEDCT_US:189210009
database_cross_reference: SNOMEDCT_US:92681005

gall bladder carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the gall bladder.
PMOID: PMO:00027296
Subclass_of: in situ carcinoma
Tree Number: T10.2.2.3.15
database_cross_reference: DO:DOID:0050612

bile duct carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the bile duct.
PMOID: PMO:00027305
Subclass_of: in situ carcinoma
Synonym: Ca in situ extrahep bile duct
Synonym: Carcinoma in situ of Extrahepatic Bile Duct
Synonym: Carcinoma in situ of Extrahepatic Bile Ducts
Synonym: Carcinoma in situ of Extrahepatic Biliary Ducts
Synonym: Carcinoma in situ of extrahepatic bile duct
Synonym: Carcinoma in situ of extrahepatic bile ducts
Synonym: Carcinoma in situ of extrahepatic bile ducts (disorder)
Synonym: Carcinoma in situ of extrahepatic bile ducts, NOS
Synonym: Carcinoma in situ of the Extrahepatic Bile Duct
Synonym: Extrahepatic Bile Duct Cancer Stage 0
Tree Number: T10.2.2.3.20
database_cross_reference: DO:DOID:0050613
database_cross_reference: MDR:10015818
database_cross_reference: MDR:10059377
database_cross_reference: MEDCIN:39502
database_cross_reference: NCI:C4442
database_cross_reference: NCI_NCI-GLOSS:CDR0000413889
database_cross_reference: RCD:X78PD
database_cross_reference: SNMI:D5-F1622
database_cross_reference: SNOMEDCT_US:92589000

bronchus carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the bronchus.
PMOID: PMO:00027297
Subclass_of: in situ carcinoma
Tree Number: T10.2.2.3.16
database_cross_reference: DO:DOID:0050614

respiratory system cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.
PMOID: PMO:00026624
Subclass_of: organ system cancer
Tree Number: T10.2.1.2.10
database_cross_reference: AOD:0000004566
database_cross_reference: DO:DOID:0050615

respiratory system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.
PMOID: PMO:00027518
Subclass_of: organ system benign neoplasm
Synonym: Ben neopl resp syst, unspec
Synonym: Benign neoplasm of respiratory system
Synonym: Benign neoplasm of respiratory system (disorder)
Synonym: Benign neoplasm of respiratory system, unspecified
Synonym: Benign neoplasm respiratory
Synonym: Benign respiratory neoplasm
Synonym: Neoplasm benign;respiratory
Synonym: Resp. syst. benign. neoplasms
Synonym: Respiratory system, unspecified
Synonym: [X]Ben neopl resp syst, unspec
Tree Number: T10.2.3.2.3
database_cross_reference: CHV:0000037464
database_cross_reference: DO:DOID:0050621
database_cross_reference: ICD10:D14.4
database_cross_reference: ICD10AM:D14.4
database_cross_reference: ICD10CM:D14.4
database_cross_reference: ICPC2EENG:R86
database_cross_reference: ICPC2P:R86004
database_cross_reference: MEDCIN:333288
database_cross_reference: MTH:U003028
database_cross_reference: RCD:ByuGK
database_cross_reference: RCD:X78nf
database_cross_reference: RCDSY:ByuGK
database_cross_reference: SNOMEDCT_US:188872007
database_cross_reference: SNOMEDCT_US:190210004
database_cross_reference: SNOMEDCT_US:255166003

reproductive organ benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm that is located_in reproductive system organs.
PMOID: PMO:00027716
Subclass_of: organ system benign neoplasm
Tree Number: T10.2.3.2.11
database_cross_reference: DO:DOID:0050622

gastrointestinal system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm located_in gastrointestinal tract organs.
PMOID: PMO:00027808
Subclass_of: organ system benign neoplasm
Tree Number: T10.2.3.2.12
database_cross_reference: DO:DOID:0050624

advanced sleep phase syndrome
type: Class
subclass of: sleep disorder
definition: A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning.
PMOID: PMO:00027884
Subclass_of: sleep disorder
Synonym: Advanced Sleep Phase Syndrome
Synonym: Circadian rhy-advc sleep
Synonym: Circadian rhythm sleep disorder, advanced sleep phase
Synonym: Circadian rhythm sleep disorder, advanced sleep phase type
Synonym: Circadian rhythm sleep disorder, advanced sleep phase type (diagnosis)
Synonym: Sleep-wake schedule disorder, advanced phase type
Synonym: Sleep-wake schedule disorder, advanced phase type (disorder)
Synonym: familial advanced sleep-phase syndrome
Synonym: sleep disorder circadian rhythm, advanced sleep phase type
Tree Number: T10.3.1.2
database_cross_reference: DO:DOID:0050628
database_cross_reference: ICD10CM:G47.22
database_cross_reference: ICD9CM:327.32
database_cross_reference: MEDCIN:358334
database_cross_reference: MSH:D020178
database_cross_reference: SNMI:D9-74131
database_cross_reference: SNOMEDCT_US:31537005

Allan-Herndon-Dudley syndrome
type: Class
subclass of: X-linked disease
definition: An X-linked disease that has material basis in mutation at is in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement.
PMOID: PMO:00028725
Subclass_of: X-linked disease
Synonym: AHDS
Synonym: ALLAN-HERNDON SYNDROME
Synonym: ALLAN-HERNDON-DUDLEY SYNDROME
Synonym: Allan-Herndon syndrome
Synonym: Allan-Herndon-Dudley Syndrome
Synonym: Allan-Herndon-Dudley syndrome (AHDS)
Synonym: MENTAL RETARDATION AND MUSCULAR ATROPHY
Synonym: MENTAL RETARDATION, X-LINKED, WITH HYPOTONIA
Synonym: MONOCARBOXYLATE TRANSPORTER 8 DEFICIENCY
Synonym: Mct8 (Slc16a2)-Specific Thyroid Hormone Cell Transporter Deficiency
Tree Number: T10.5.3.4.5
database_cross_reference: DO:DOID:0050631
database_cross_reference: JABL:21
database_cross_reference: MSH:C537047
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118843
database_cross_reference: OMIM:300095
database_cross_reference: OMIM:300523
database_cross_reference: SNOMEDCT_US:702327009

familial visceral amyloidosis
type: Class
subclass of: amyloidosis
PMOID: PMO:00028846
Subclass_of: amyloidosis
Synonym: AMYLOIDOSIS VIII
Synonym: AMYLOIDOSIS, FAMILIAL RENAL
Synonym: AMYLOIDOSIS, FAMILIAL VISCERAL
Synonym: AMYLOIDOSIS, SYSTEMIC NONNEUROPATHIC
Synonym: Amyloid nephrop of Ostertag
Synonym: Amyloid nephropathy of Ostertag
Synonym: Amyloidosis 8
Synonym: Amyloidosis VIII
Synonym: Amyloidosis, familial renal
Synonym: Amyloidosis, familial visceral
Tree Number: T10.6.1.2.4
database_cross_reference: DO:DOID:0050636
database_cross_reference: MSH:C538249
database_cross_reference: OMIM:105200
database_cross_reference: OMIM:107680
database_cross_reference: OMIM:134820
database_cross_reference: OMIM:153450
database_cross_reference: RCD:X40Pv
database_cross_reference: SNMI:D6-94570
database_cross_reference: SNOMEDCT_US:66451004

Finnish type amyloidosis
type: Class
subclass of: amyloidosis
PMOID: PMO:00028843
Subclass_of: amyloidosis
Synonym: Amyl cran corneal dystr
Synonym: Amyloid corneal dystrophy
Synonym: Amyloid cranial neuropathy with lattice corneal dystrophy
Synonym: Biber haab dimmer dystrophy
Synonym: Famil amyloid polyneuropath V
Synonym: Familial Amyloid Neuropathy, Finnish Type
Synonym: Familial Amyloid Polyneuropathy, Type V
Synonym: Familial amyloid neuropathy, Finnish type
Synonym: Familial amyloid neuropathy, Finnish type (disorder)
Synonym: Familial amyloid polyneuropathy type V
Tree Number: T10.6.1.2.1
database_cross_reference: HPO:HP:0001149
database_cross_reference: ICD10CM:H18.54
database_cross_reference: ICD9CM:371.54
database_cross_reference: MDR:10024039
database_cross_reference: MEDCIN:36703
database_cross_reference: MSH:D028227
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU036631
database_cross_reference: RCD:F4B54
database_cross_reference: SNM:M-55110
database_cross_reference: SNMI:D6-94556
database_cross_reference: SNMI:DA-75412
database_cross_reference: SNOMEDCT_US:1192004
database_cross_reference: SNOMEDCT_US:193835001
database_cross_reference: SNOMEDCT_US:231932008
database_cross_reference: SNOMEDCT_US:361199007
database_cross_reference: SNOMEDCT_US:419398009
database_cross_reference: SNOMEDCT_US:71041007

transthyretin amyloidosis
type: Class
subclass of: amyloidosis
definition: An amyloidosis that is characterized by a loss of sensation in the extremities, cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis resulting from abnormal deposits of amyloid protein in the body's organs and tissues and has_material_basis_in autosomal dominant inheritance of mutations in the TTR gene.
PMOID: PMO:00028847
Subclass_of: amyloidosis
Synonym: AMYLOID POLYNEUROPATHY, FAMILIAL
Synonym: AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED
Synonym: Amyloidosis, Hereditary, Transthyretin-Related
Synonym: Amyloidosis, hereditary, transthyretin-related
Synonym: Corino de Andrade's disease
Synonym: FAP
Synonym: Familial Transthyretin Cardiac Amyloidosis
Synonym: Familial transthyretin amyloidosis
Synonym: HEREDITARY AMYLOIDOSIS, TRANSTHYRETIN-RELATED
Synonym: Hereditary Amyloidosis, Transthyretin-Related
Tree Number: T10.6.1.2.5
database_cross_reference: DO:DOID:0050638
database_cross_reference: MSH:C567782
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:105210
database_cross_reference: OMIM:176300

primary cutaneous amyloidosis
type: Class
subclass of: amyloidosis
PMOID: PMO:00028844
Subclass_of: amyloidosis
Synonym: AD type amyloidosis
Synonym: AD type amyloidosis (disorder)
Synonym: Amyloid lichen
Synonym: Amyloidosis cutis
Synonym: Amyloidosis of dermis
Synonym: Amyloidosis of skin
Synonym: Amyloidosis of skin (disorder)
Synonym: Amyloidosis, Primary Cutaneous
Synonym: Cutaneous amyloidosis
Synonym: Cutaneous amyloidosis (disorder)
Tree Number: T10.6.1.2.2
database_cross_reference: CHV:0000026302
database_cross_reference: HPO:HP:0012309
database_cross_reference: ICD10:L99.0
database_cross_reference: ICD10AM:L99.0
database_cross_reference: MDR:10011659
database_cross_reference: MDR:10024427
database_cross_reference: MSH:C562642
database_cross_reference: RCD:M2y9.
database_cross_reference: SNM:M-55180
database_cross_reference: SNMI:D6-94640
database_cross_reference: SNOMEDCT_US:201337008
database_cross_reference: SNOMEDCT_US:281882003
database_cross_reference: SNOMEDCT_US:282834007
database_cross_reference: SNOMEDCT_US:61985005
database_cross_reference: SNOMEDCT_US:718105008

anonychia congenita
type: Class
subclass of: nail disease
PMOID: PMO:00033768
Subclass_of: nail disease
Synonym: ANN - Anonychia
Synonym: ANONYCHIA
Synonym: Absent nails
Synonym: Anonychia
Synonym: Anonychia (disorder)
Synonym: Anonychia congenita
Synonym: Aplastic nails
Synonym: Claw absent
Synonym: Complete absence of all fingernails (anonychia), congenital
Synonym: Congenital absence of nails (anonychia)
Tree Number: T10.8.12.1.10
database_cross_reference: HPO:HP:0001798
database_cross_reference: ICD10:Q84.3
database_cross_reference: ICD10AM:Q84.3
database_cross_reference: ICD10CM:Q84.3
database_cross_reference: MEDCIN:99062
database_cross_reference: MSH:C536377
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:757.5
database_cross_reference: OMIM:MTHU008928
database_cross_reference: OMIM:MTHU023062
database_cross_reference: OMIM:MTHU037245
database_cross_reference: RCD:PH50.
database_cross_reference: SNM:M-21000
database_cross_reference: SNMI:D4-41401
database_cross_reference: SNOMEDCT_US:23610003
database_cross_reference: SNOMEDCT_VET:23610003

arterial calcification of infancy
type: Class
subclass of: vascular disease
PMOID: PMO:00032007
Subclass_of: vascular disease
Synonym: ARTERIAL CALCIFICATION, GENERALIZED, OF INFANCY, 1
Synonym: ARTERIAL CALCIFICATION, IDIOPATHIC INFANTILE
Synonym: ARTERIOPATHY, OCCLUSIVE INFANTILE
Synonym: Arterial Calcification, Generalized, Of Infancy
Synonym: Arterial Calcification, Idiopathic Infantile
Synonym: Arterial calcification of infancy
Synonym: Arteriopathy, Occlusive Infantile
Synonym: GACI
Synonym: GACI1
Synonym: Generalized Arterial Calcification of Infancy 1
Tree Number: T10.8.3.3.13
database_cross_reference: MSH:C537440
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C128805
database_cross_reference: OMIM:173335
database_cross_reference: OMIM:208000

arterial tortuosity syndrome
type: Class
subclass of: connective tissue disease
definition: A connective tissue disease that is characterized by elongation and generalized tortuosity of the major arteries including the aorta.
PMOID: PMO:00032319
Subclass_of: connective tissue disease
Synonym: ARTERIAL TORTUOSITY SYNDROME
Synonym: ATS
Synonym: Arterial Tortuosity
Synonym: Arterial Tortuosity Syndrome
Synonym: Arterial tortuosity
Synonym: Arterial tortuosity syndrome
Synonym: Arterial tortuosity syndrome (diagnosis)
Synonym: Arterial tortuosity syndrome (disorder)
Tree Number: T10.8.4.1.23
database_cross_reference: DO:DOID:0050645
database_cross_reference: HPO:HP:0005116
database_cross_reference: ICD10CM:Q87.82
database_cross_reference: MEDCIN:363700
database_cross_reference: MSH:C565942
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:208050
database_cross_reference: OMIM:606145
database_cross_reference: SNOMEDCT_US:458432002

atransferrinemia
type: Class
subclass of: metal metabolism disorder
PMOID: PMO:00029029
Subclass_of: metal metabolism disorder
Synonym: ATRANSFERRINEMIA
Synonym: Atransferrinemia
Synonym: Congenital Atransferrinemia
Synonym: Congenital atransferinaemia
Synonym: Congenital atransferinemia
Synonym: Congenital atransferinemia (disorder)
Synonym: Congenital atransferrinaemia
Synonym: Congenital atransferrinemia
Synonym: Congenital atransferrinemia (disorder)
Synonym: Familial Hypotransferrinemia
Tree Number: T10.6.2.4.7
database_cross_reference: DO:DOID:0050649
database_cross_reference: HPO:HP:0012239
database_cross_reference: MSH:C538259
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C125693
database_cross_reference: OMIM:190000
database_cross_reference: OMIM:209300
database_cross_reference: SNM:D-4106
database_cross_reference: SNMI:DC-13020
database_cross_reference: SNOMEDCT_US:111571009

organ system cancer
type: Class
subclass of: cancer
definition: A cancer that is classified based on the organ it starts in.
PMOID: PMO:00025424
Subclass_of: cancer
Synonym: NEOPL SITE
Synonym: NEOPL SITES
Synonym: Neoplasm Site
Synonym: Neoplasm Sites
Synonym: Neoplasm by Site
Synonym: Neoplasms by Site
Synonym: Neoplasms by Site [Disease/Finding]
Synonym: Neoplasms by Sites
Synonym: SITE NEOPL
Synonym: SITES NEOPL
Tree Number: T10.2.1.2
database_cross_reference: CSP:4009-0019
database_cross_reference: DO:DOID:0050686
database_cross_reference: MSH:D009371
database_cross_reference: NCI:C3263
database_cross_reference: NDFRT:N0000002130

cell type cancer
type: Class
subclass of: cancer
definition: A cancer that is classified by the type of cell from which it is derived.
PMOID: PMO:00025252
Subclass_of: cancer
Tree Number: T10.2.1.1
database_cross_reference: DO:DOID:0050687

brachydactyly-syndactyly syndrome
type: Class
subclass of: autosomal genetic disease
PMOID: PMO:00028394
Subclass_of: autosomal genetic disease
Synonym: BDSD
Synonym: BRACHYDACTYLY-SYNDACTYLY SYNDROME
Synonym: Brachydactyly-Syndactyly Syndrome
Tree Number: T10.5.3.2.3
database_cross_reference: DO:DOID:0050689
database_cross_reference: MSH:C565193
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:610713

fetal alcohol spectrum disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.
PMOID: PMO:00027996
Subclass_of: specific developmental disorder
Synonym: FASD
Synonym: FASDs
Synonym: Fetal Alcohol Spectrum Disorder
Synonym: Fetal Alcohol Spectrum Disorder (disorder)
Synonym: Fetal Alcohol Spectrum Disorders
Synonym: Foetal Alcohol Spectrum Disorder
Tree Number: T10.3.5.1.6
database_cross_reference: DO:DOID:0050696
database_cross_reference: MSH:D063647
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92780
database_cross_reference: NCI_NICHD:C92780
database_cross_reference: SNOMEDCT_US:609437000

funisitis
type: Class
subclass of: connective tissue disease
definition: A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.
PMOID: PMO:00032274
Subclass_of: connective tissue disease
Synonym: Funisitides
Synonym: Funisitis
Synonym: Funisitis (disorder)
Synonym: Inflammation of umbilical cord
Synonym: inflammation of umbilical cord
Synonym: inflammation of umbilical cord (physical finding)
Tree Number: T10.8.4.1.7
database_cross_reference: DO:DOID:0050698
database_cross_reference: MDR:10064502
database_cross_reference: MEDCIN:9482
database_cross_reference: MSH:D002821
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C97077
database_cross_reference: NCI_NICHD:C97077
database_cross_reference: SNOMEDCT_US:396343006

cardiomyopathy
type: Class
subclass of: heart disease
definition: A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.
PMOID: PMO:00031626
Subclass_of: heart disease
Synonym: CARDIOMEGALY, IDIOPATHIC
Synonym: CARDIOMYOPATHY IDIOPATHIC
Synonym: CARDIOMYOPATHY, NONCORONARY
Synonym: Cardiomyopathies
Synonym: Cardiomyopathies, Primary
Synonym: Cardiomyopathy primary
Synonym: Cardiomyopathy primary NOS
Synonym: Cardiomyopathy, Primary
Synonym: Cardiomyopathy, idiopathic
Synonym: Cardiomyopathy;primary
Tree Number: T10.8.3.2.3
database_cross_reference: BI:BI00080
database_cross_reference: CCPSS:1017830
database_cross_reference: CHV:0000025789
database_cross_reference: COSTAR:U000352
database_cross_reference: DO:DOID:0050700
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000918
database_cross_reference: ICPC2P:K84017
database_cross_reference: MDR:10007641
database_cross_reference: MDR:10052650
database_cross_reference: MDR:10061029
database_cross_reference: MSH:D009202
database_cross_reference: MTHICD9:425.4
database_cross_reference: NCI:C53654
database_cross_reference: SNMI:D3-20100
database_cross_reference: SNMI:D3-20110
database_cross_reference: SNOMEDCT_US:20072003
database_cross_reference: SNOMEDCT_US:89461002

3-Methylcrotonyl-CoA carboxylase deficiency
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.
PMOID: PMO:00029192
Subclass_of: amino acid metabolic disorder
Synonym: 3 Methylcrotonyl-CoA carboxylase deficiency
Synonym: 3 Methylcrotonylglycinuria
Synonym: 3 alpha methylcrotonylglycinuria 1
Synonym: 3-@METHYLCROTONYL-CoA CARBOXYLASE 1 DEFICIENCY
Synonym: 3-MCC Deficiency
Synonym: 3-METHYLCROTONYL-CoA CARBOXYLASE 1 DEFICIENCY
Synonym: 3-METHYLCROTONYLGLYCINURIA I
Synonym: 3-Mcc Deficiency
Synonym: 3-Methylcrot-CoA carboxyl def
Synonym: 3-Methylcrotonyl-CoA Carboxylase Deficiency
Tree Number: T10.6.2.15.14
database_cross_reference: DO:DOID:0050710
database_cross_reference: LNC:LP174560-5
database_cross_reference: LNC:MTHU047543
database_cross_reference: MEDCIN:312769
database_cross_reference: MSH:C535308
database_cross_reference: NCI:C98674
database_cross_reference: NCI_NICHD:C98674
database_cross_reference: OMIM:210200
database_cross_reference: OMIM:609010
database_cross_reference: RCD:X40T5
database_cross_reference: SNMI:D6-B2210
database_cross_reference: SNOMEDCT_US:124719001
database_cross_reference: SNOMEDCT_US:13144005

fatal infantile encephalocardiomyopathy
type: Class
subclass of: mitochondrial metabolism disease
definition: A mitochondrial metabolism disease that has_material_basis_in a mutation in the SCO2 gene which encodes a COX assembly factor and results in deficiency of cytochrome c oxidase.
PMOID: PMO:00028979
Subclass_of: mitochondrial metabolism disease
Synonym: CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASE DEFICIENCY 1
Synonym: CEMCOX1
Synonym: CYTOCHROME c OXIDASE DEFICIENCY, FATAL INFANTILE, WITH CARDIOENCEPHALOMYOPATHY
Synonym: Cardioencephalomyopathy, Fatal Infantile, due to Cytochrome C Oxidase Deficiency
Synonym: Cytochrome C Oxidase Deficiency, Fatal Infantile, with Cardioencephalomyopathy
Synonym: cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency
Synonym: fatal infantile COX deficiency
Synonym: fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency
Tree Number: T10.6.2.1.16
database_cross_reference: DO:DOID:0050713
database_cross_reference: MSH:C565784
database_cross_reference: OMIM:604272
database_cross_reference: OMIM:604377

vitamin metabolic disorder
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder resulting from a deficiency in vitamin or vitamin cofactor transport or metabolism.
PMOID: PMO:00029156
Subclass_of: inherited metabolic disorder
Tree Number: T10.6.2.13
database_cross_reference: DO:DOID:0050718

cerebral folate receptor alpha deficiency
type: Class
subclass of: vitamin metabolic disorder
definition: A vitamin metabolic disorder that has_material_basis_in mutations in the folate receptor 1 (FOLR1) gene coding for folate receptor alpha (FRalpha), is located_in the brain and is characterized by progressive movement disturbance, psychomotor decline, and epilepsy.
PMOID: PMO:00029161
Subclass_of: vitamin metabolic disorder
Synonym: Cerebral folate deficiency
Synonym: Cerebral folate transport deficiency
Synonym: Cerebral folate transport deficiency (disorder)
Synonym: NEURODEGENERATION DUE TO CEREBRAL FOLATE TRANSPORT DEFICIENCY
Synonym: Neurodegeneration Due To Cerebral Folate Transport Deficiency
Synonym: Neurodegeneration due to cerebral folate transport deficiency
Tree Number: T10.6.2.13.3
database_cross_reference: DO:DOID:0050719
database_cross_reference: HPO:HP:0012446
database_cross_reference: MSH:C567791
database_cross_reference: OMIM:136430
database_cross_reference: OMIM:613068
database_cross_reference: SNOMEDCT_US:711403001

ornithine translocase deficiency
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that has_material_basis in deficiency of ornithine translocase resulting in the accumulation of ammonia in the blood.
PMOID: PMO:00029177
Subclass_of: amino acid metabolic disorder
Synonym: HHH
Synonym: HHH - Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome
Synonym: HHH - Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome
Synonym: HHH SYNDROME
Synonym: HHH syndrome
Synonym: HHH-Hyperornithinaemia-hyperammonaemia-homocitrullinuria syn
Synonym: HHH-Hyperornithinemia-hyperammonemia-homocitrullinuria syn
Synonym: HHH-Hyprornith-hypramm-homocit
Synonym: HHHS
Synonym: HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA SYNDROME
Tree Number: T10.6.2.15.6
database_cross_reference: DO:DOID:0050720
database_cross_reference: ICD10CM:E72.4
database_cross_reference: LNC:LA12497-6
database_cross_reference: MEDCIN:36137
database_cross_reference: MSH:C538380
database_cross_reference: NCI:C129029
database_cross_reference: OMIM:238970
database_cross_reference: OMIM:603861
database_cross_reference: RCD:X40SJ
database_cross_reference: RCDAE:X40SJ
database_cross_reference: SNMI:D6-A5120
database_cross_reference: SNOMEDCT_US:30287008

serine deficiency
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that has_material_basis_in defects in the biosynthesis of the amino acid L-serine.
PMOID: PMO:00029230
Subclass_of: amino acid metabolic disorder
Tree Number: T10.6.2.15.29
database_cross_reference: DO:DOID:0050721

glycogen metabolism disorder
type: Class
subclass of: carbohydrate metabolic disorder
definition: A carbohydrate metabolism disorder that is characterized by abnormal accumulation or depletion of liver glycogen.
PMOID: PMO:00029133
Subclass_of: carbohydrate metabolic disorder
Tree Number: T10.6.2.11.11
database_cross_reference: DO:DOID:0050728

coenzyme Q10 deficiency disease
type: Class
subclass of: mitochondrial metabolism disease
definition: A mitochondrial metabolism disease that is characterized by a deficiency of CoQ10 resulting from reduced biosynthesis.
PMOID: PMO:00028992
Subclass_of: mitochondrial metabolism disease
Synonym: COENZYME Q DEFICIENCY 1
Synonym: COENZYME Q10 DEFICIENCY, PRIMARY
Synonym: COENZYME Q10 DEFICIENCY, PRIMARY, 1
Synonym: COQ10D1
Synonym: CoQ DEFICIENCY 1
Synonym: CoQ10 DEFICIENCY, PRIMARY, 1
Synonym: UBIQUINONE DEFICIENCY 1
Tree Number: T10.6.2.1.29
database_cross_reference: DO:DOID:0050730
database_cross_reference: OMIM:607426
database_cross_reference: OMIM:609825

vitamin B12 deficiency
type: Class
subclass of: vitamin metabolic disorder
definition: A vitamin metabolic disorder that results from low blood levels of vitamin B12.
PMOID: PMO:00029158
Subclass_of: vitamin metabolic disorder
Synonym: CYANOCOBALAMIN DEFICIENCY
Synonym: Cobalamin deficiency
Synonym: Cobalamin deficiency (disorder)
Synonym: Cyanocobalamin deficiency
Synonym: DEFIC VITAMIN B 12
Synonym: DEFIC VITAMIN B12
Synonym: Deficiencies, Vitamin B12
Synonym: Deficiency of vitamin B12
Synonym: Deficiency of vitamin B12 (disorder)
Tree Number: T10.6.2.13.2
database_cross_reference: CCPSS:1001601
database_cross_reference: CHV:0000013051
database_cross_reference: COSTAR:215
database_cross_reference: COSTAR:791
database_cross_reference: COSTAR:792
database_cross_reference: CSP:2116-7456
database_cross_reference: DO:DOID:0050731
database_cross_reference: DO:DOID:8459
database_cross_reference: HPO:HP:0100502
database_cross_reference: ICD10CM:E53.8
database_cross_reference: ICPC2P:T91016
database_cross_reference: LCH_NW:sh85143972
database_cross_reference: MDR:10047609
database_cross_reference: MDR:10052831
database_cross_reference: MEDCIN:273146
database_cross_reference: MSH:D014806
database_cross_reference: MTH:215
database_cross_reference: MTH:792
database_cross_reference: MTHICD9:266.2
database_cross_reference: NDFRT:N0000003133
database_cross_reference: RCD:C2621
database_cross_reference: SNM:D-1818
database_cross_reference: SNOMEDCT_US:124904006
database_cross_reference: SNOMEDCT_US:190634004

X-linked disease
type: Class
subclass of: monogenic disease
definition: A monogenic disease that has_material_basis_in muations in genes on the X chromosome.
PMOID: PMO:00028720
Subclass_of: monogenic disease
Tree Number: T10.5.3.4
database_cross_reference: DO:DOID:0050735

autosomal dominant disease
type: Class
subclass of: autosomal genetic disease
definition: An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease.
PMOID: PMO:00028395
Subclass_of: autosomal genetic disease
Tree Number: T10.5.3.2.4
database_cross_reference: DO:DOID:0050736

autosomal recessive disease
type: Class
subclass of: autosomal genetic disease
definition: An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop.
PMOID: PMO:00028505
Subclass_of: autosomal genetic disease
Tree Number: T10.5.3.2.9
database_cross_reference: DO:DOID:0050737

Y-linked disease
type: Class
subclass of: monogenic disease
definition: A monogenic disease that has_material_basis_in muations on the Y chromosome.
PMOID: PMO:00028719
Subclass_of: monogenic disease
Tree Number: T10.5.3.3
database_cross_reference: DO:DOID:0050738

autosomal genetic disease
type: Class
subclass of: monogenic disease
definition: A monogenic disease that is has material basis in a mutation in a single gene on one of the non-sex chromosomes.
PMOID: PMO:00028391
Subclass_of: monogenic disease
Tree Number: T10.5.3.2
database_cross_reference: DO:DOID:0050739

Qazi Markouizos syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by hypotonia, congenital fiber type disproportion and dysharmonic skeletal maturation.
PMOID: PMO:00025240
Subclass_of: syndrome
Synonym: Dysharmonic skeletal maturation - muscular fibre disproportion
Synonym: Dysharmonic skeletal maturation and muscular fiber disproportion syndrome
Synonym: Dysharmonic skeletal maturation and muscular fibre disproportion syndrome
Synonym: Dysharmonic skeletal maturation muscular fibre disproportion
Synonym: PUERTO RICAN INFANT HYPOTONIA SYNDROME
Synonym: Puerto Rican Infant Hypotonia Syndrome
Synonym: Puerto Rican infant hypotonia syndrome
Synonym: Puerto Rican infant hypotonia syndrome (disorder)
Synonym: Puertorican infant hypotonia syndrome
Synonym: Qazi-Markouizos syndrome
Tree Number: T10.1.100
database_cross_reference: DO:DOID:0050740
database_cross_reference: MSH:C536259
database_cross_reference: OMIM:600096
database_cross_reference: SNOMEDCT_US:721887007

alcohol dependence
type: Class
subclass of: substance dependence
PMOID: PMO:00027932
Subclass_of: substance dependence
Synonym: (Alcohol dependence syndrome [including alcoholism]) or (alcohol problem drinking)
Synonym: (Alcohol dependence syndrome [including alcoholism]) or (alcohol problem drinking) (disorder)
Synonym: ALCOHOL ABUSE CHRONIC
Synonym: ALCOHOL DEPENDENCE
Synonym: ALCOHOLIC INTOX CHRONIC
Synonym: ALCOHOLISM
Synonym: ALCOHOLISM CHRONIC
Synonym: Abuse;alcohol;chronic
Synonym: Addiction, Alcohol
Synonym: Addiction, alcohol
Tree Number: T10.3.3.3.3
database_cross_reference: AOD:0000004288
database_cross_reference: AOD:0000004298
database_cross_reference: AOD:0000022872
database_cross_reference: AOD:0000022873
database_cross_reference: AOD:0000022874
database_cross_reference: AOD:0000022875
database_cross_reference: BI:BI00005
database_cross_reference: CCPSS:0015910
database_cross_reference: CCPSS:0052934
database_cross_reference: CCPSS:0057169
database_cross_reference: CCPSS:1002407
database_cross_reference: CHV:0000000875
database_cross_reference: CHV:0000037440
database_cross_reference: CHV:0000052652
database_cross_reference: COSTAR:035
database_cross_reference: COSTAR:039
database_cross_reference: CSP:0080-8925
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000063
database_cross_reference: DXP:U000121
database_cross_reference: HPO:HP:0030955
database_cross_reference: ICD10:F10.2
database_cross_reference: ICD10AM:F10.2
database_cross_reference: ICD10AMAE:F10.2
database_cross_reference: ICD10CM:F10.2
database_cross_reference: ICD9CM:303
database_cross_reference: ICPC2EENG:P15
database_cross_reference: ICPC2P:P15001
database_cross_reference: ICPC2P:P15006
database_cross_reference: ICPC2P:P15007
database_cross_reference: ICPC2P:P15014
database_cross_reference: ICPC2P:P15016
database_cross_reference: ICPC2P:P15018
database_cross_reference: LCH:U000133
database_cross_reference: LCH_NW:sh85003292
database_cross_reference: LNC:LA6152-8
database_cross_reference: MDR:10001585
database_cross_reference: MDR:10001586
database_cross_reference: MDR:10001590
database_cross_reference: MDR:10001594
database_cross_reference: MDR:10001639
database_cross_reference: MDR:10013037
database_cross_reference: MDR:10049894
database_cross_reference: MDR:10063499
database_cross_reference: MEDCIN:32401
database_cross_reference: MEDCIN:351648
database_cross_reference: MEDLINEPLUS:120
database_cross_reference: MSH:D000437
database_cross_reference: MTH:035
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:303.9
database_cross_reference: NCI:C93040
database_cross_reference: NCI_NCI-GLOSS:CDR0000450090
database_cross_reference: NCI_NCI-GLOSS:CDR0000457951
database_cross_reference: NDFRT:N0000000353
database_cross_reference: OMIM:103780
database_cross_reference: PSY:01665
database_cross_reference: PSY:01750
database_cross_reference: PSY:09180
database_cross_reference: RCD:E2310
database_cross_reference: RCD:E231z
database_cross_reference: RCD:E23z.
database_cross_reference: RCD:XE1YQ
database_cross_reference: RCD:XE1ZE
database_cross_reference: RCD:Xa2lt

nicotine dependence
type: Class
subclass of: substance dependence
PMOID: PMO:00027931
Subclass_of: substance dependence
Synonym: Addiction;nicotine
Synonym: Dependence, Nicotine
Synonym: Nicotine Addiction
Synonym: Nicotine Dependence
Synonym: Nicotine addiction
Synonym: Nicotine dependence
Synonym: Nicotine dependence (disorder)
Synonym: Nicotine dependence, unspecified
Synonym: addiction nicotine
Synonym: addictions nicotine
Tree Number: T10.3.3.3.2
database_cross_reference: CHV:0000008708
database_cross_reference: DO:DOID:0050742
database_cross_reference: ICD10CM:F17
database_cross_reference: ICD10CM:F17.2
database_cross_reference: ICD10CM:F17.20
database_cross_reference: ICPC2P:P17001
database_cross_reference: LCH_NW:sh2005002478
database_cross_reference: MDR:10056478
database_cross_reference: MDR:10057852
database_cross_reference: MEDCIN:32712
database_cross_reference: MSH:D014029
database_cross_reference: NCI:C54203
database_cross_reference: SNMI:D9-30170
database_cross_reference: SNOMEDCT_US:56294008

deafness-dystonia-optic neuronopathy syndrome
type: Class
subclass of: mitochondrial metabolism disease
definition: A mitochondrial metabolism disease that is characterized by hearing loss that begins early in life, problems with movement, impaired vision, and behavior problems, and has_material_basis_in mutations in the TIMM8A gene resulting in abnormal protein transport within the mitochondria.
PMOID: PMO:00028991
Subclass_of: mitochondrial metabolism disease
Synonym: DDP
Synonym: DDS
Synonym: DEAFNESS SYNDROME, PROGRESSIVE, WITH BLINDNESS, DYSTONIA, FRACTURES, AND MENTAL DEFICIENCY
Synonym: DEAFNESS-DYSTONIA-OPTIC ATROPHY SYNDROME
Synonym: DYSTONIA-DEAFNESS SYNDROME
Synonym: Deafness (DFN-1) dystonia, mental deficiency and blindness
Synonym: Deafness Dystonia Optic Atrophy Syndrome
Synonym: Deafness Dystonia Optic Neuronopathy Syndrome
Synonym: Deafness Syndrome, Progressive, With Blindness, Dystonia, Fractures, And Mental Deficiency
Synonym: Deafness dystonia syndrome
Tree Number: T10.6.2.1.28
database_cross_reference: DO:DOID:0050757
database_cross_reference: DRUGBANK:DB12117
database_cross_reference: JABL:275
database_cross_reference: JABL:459
database_cross_reference: MSH:C535808
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300356
database_cross_reference: OMIM:304700
database_cross_reference: SNOMEDCT_US:702423009

metabolic acidosis
type: Class
subclass of: acquired metabolic disease
definition: An acquired metabolic disease that characterized by excessive production of acid.
PMOID: PMO:00028840
Subclass_of: acquired metabolic disease
Synonym: ACIDOSIS METABOLIC
Synonym: Acidoses, Metabolic
Synonym: Acidosis
Synonym: Acidosis metabolic
Synonym: Acidosis, Metabolic
Synonym: Acidosis, metabolic
Synonym: METABOLIC ACIDOSIS
Synonym: Metabolic Acidoses
Synonym: Metabolic Acidosis
Synonym: Metabolic acidosis
Tree Number: T10.6.1.1
database_cross_reference: AOD:0000005823
database_cross_reference: BI:BI00352
database_cross_reference: CCPSS:1005370
database_cross_reference: CHV:0000021246
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:ACIDOSIS
database_cross_reference: DO:DOID:0050758
database_cross_reference: DXP:U002556
database_cross_reference: HPO:HP:0001942
database_cross_reference: ICD10CM:E87.2
database_cross_reference: MDR:10000492
database_cross_reference: MDR:10027417
database_cross_reference: MDR:10027419
database_cross_reference: MEDCIN:30580
database_cross_reference: MSH:D000138
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:276.2
database_cross_reference: NCI:C28228
database_cross_reference: NCI_CTCAE:E12237
database_cross_reference: NCI_NCI-GLOSS:CDR0000044332
database_cross_reference: NCI_NICHD:C28228
database_cross_reference: OMIM:MTHU036658
database_cross_reference: RCD:X40PT
database_cross_reference: SNM:D-1085
database_cross_reference: SNMI:D6-23200
database_cross_reference: SNOMEDCT_US:59455009

paramyloidosis
type: Class
subclass of: amyloidosis
PMOID: PMO:00028845
Subclass_of: amyloidosis
Tree Number: T10.6.1.2.3
database_cross_reference: DO:DOID:0050761

adenylosuccinase lyase deficiency
type: Class
subclass of: amino acid metabolic disorder
PMOID: PMO:00029236
Subclass_of: amino acid metabolic disorder
Synonym: ADENYLOSUCCINASE DEFICIENCY
Synonym: ADENYLOSUCCINATE LYASE DEFICIENCY
Synonym: ADSL DEFICIENCY
Synonym: ADSL Deficiency
Synonym: ADSLD
Synonym: ASase - Adenylosuccinate lyase deficiency
Synonym: ASase-Adenylosuccin lyase def
Synonym: Adenylosuccinase deficiency
Synonym: Adenylosuccinate deficiency
Synonym: Adenylosuccinate lyase defic
Tree Number: T10.6.2.15.30
database_cross_reference: DO:DOID:0050762
database_cross_reference: MSH:C538235
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:103050
database_cross_reference: OMIM:608222
database_cross_reference: RCD:X40Un
database_cross_reference: SNMI:D6-40A00
database_cross_reference: SNOMEDCT_US:124631006
database_cross_reference: SNOMEDCT_US:15285008

ARC syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by congenital joint contractures, renal tubular dysfunction, cholestasis, severe failure to thrive, ichthyosis, and a defect in platelet alpha-granule biogenesis. It has material basis in homozygous or compound heterozygous mutation in the VPS33B gene or has masterial basis in homozygous or compound heterozygous mutation in the VIPAR gene on chromosome 14q24.3.
PMOID: PMO:00025202
Subclass_of: syndrome
Synonym: ARC (arthrogryposis, renal dysfunction, cholestasis) syndrome
Synonym: ARC SYNDROME
Synonym: ARCS
Synonym: ARCS1
Synonym: ARTHROGRYPOSIS, RENAL DYSFUNCTION, AND CHOLESTASIS
Synonym: ARTHROGRYPOSIS, RENAL DYSFUNCTION, AND CHOLESTASIS 1
Synonym: Arthrogryposis multiplex congenita, renal dysfunction, and cholestasis
Synonym: Arthrogryposis renal dysfunction cholestasis syndrome
Synonym: Arthrogryposis with renal dysfunction and cholestasis syndrome
Synonym: Arthrogryposis with renal dysfunction and cholestasis syndrome (disorder)
Tree Number: T10.1.80
database_cross_reference: DO:DOID:0050763
database_cross_reference: MSH:C535382
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:208085
database_cross_reference: OMIM:608552
database_cross_reference: SNOMEDCT_US:720513002

N syndrome
type: Class
subclass of: syndrome
PMOID: PMO:00025182
Subclass_of: syndrome
Synonym: N SYNDROME
Synonym: NSX
Tree Number: T10.1.63
database_cross_reference: DO:DOID:0050769
database_cross_reference: MSH:C536108
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:310465

phaeochromocytoma
type: Class
subclass of: cell type benign neoplasm
definition: An adrenal medulla cancer that is characterized by overproduction of adrenaline.
PMOID: PMO:00027413
Subclass_of: cell type benign neoplasm
Synonym: Adrenal Gland Chromaffin Paraganglioma
Synonym: Adrenal Gland Chromaffinoma
Synonym: Adrenal Gland Paraganglioma
Synonym: Adrenal Gland Pheochromocytoma
Synonym: Adrenal Medullary Paraganglioma
Synonym: Adrenal Medullary Pheochromocytoma
Synonym: Adrenal Pheochromocytoma
Synonym: Adrenal medullary paraganglioma
Synonym: Adrenal pheochromocytoma
Synonym: CHROMAFFINOMA, MEDULLARY
Tree Number: T10.2.3.1.12
database_cross_reference: AOD:0000004641
database_cross_reference: CCPSS:0041386
database_cross_reference: CHV:0000009623
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2012-7663
database_cross_reference: CST:NEOPL
database_cross_reference: DO:DOID:0050771
database_cross_reference: DO:DOID:0050892
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001489
database_cross_reference: HPO:HP:0002666
database_cross_reference: HPO:HP:0006748
database_cross_reference: ICD10AM:M8700/0
database_cross_reference: ICD10AMAE:M8700/0
database_cross_reference: ICPC2P:T73008
database_cross_reference: LCH:U003619
database_cross_reference: LCH_NW:sh85100702
database_cross_reference: MDR:10034800
database_cross_reference: MDR:10034876
database_cross_reference: MEDCIN:351578
database_cross_reference: MEDLINEPLUS:1237
database_cross_reference: MSH:D010673
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3326
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CTEP-SDC:10034876
database_cross_reference: NCI_NCI-GLOSS:CDR0000322877
database_cross_reference: NDFRT:N0000002390
database_cross_reference: OMIM:164761
database_cross_reference: OMIM:171300
database_cross_reference: OMIM:185470
database_cross_reference: OMIM:602690
database_cross_reference: OMIM:605995
database_cross_reference: OMIM:608537
database_cross_reference: OMIM:MTHU004454
database_cross_reference: OMIM:MTHU015027
database_cross_reference: PDQ:CDR0000039816
database_cross_reference: RCD:BBD9.
database_cross_reference: RCD:Xa99P
database_cross_reference: RCDAE:BBD9.
database_cross_reference: RCDAE:Xa99P
database_cross_reference: RCDSY:BBD9.
database_cross_reference: SNM:D-2947
database_cross_reference: SNM:M-8700/0
database_cross_reference: SNMI:M-87000
database_cross_reference: SNOMEDCT_US:154555009
database_cross_reference: SNOMEDCT_US:188337000
database_cross_reference: SNOMEDCT_US:269615000
database_cross_reference: SNOMEDCT_US:302835009
database_cross_reference: SNOMEDCT_US:360332001
database_cross_reference: SNOMEDCT_US:360335004
database_cross_reference: SNOMEDCT_US:399343007
database_cross_reference: SNOMEDCT_US:85583005

Joubert syndrome
type: Class
subclass of: ciliopathy
definition: A Joubert syndrome that has_material_basis_in homozygous mutation in the INPP5E gene on chromosome 9q34.
PMOID: PMO:00028292
Subclass_of: ciliopathy
Synonym: Agenesis of Cerebellar Vermis
Synonym: Agenesis of cerebellar vermis
Synonym: CEREBELLOOCULORENAL SYNDROME 1
Synonym: CEREBELLOPARENCHYMAL DISORDER IV
Synonym: CORS1
Synonym: CPD4
Synonym: Cerebellar vermis agenesis
Synonym: Cerebellar vermis aplasia
Synonym: Cerebello-Oculo-Renal Syndrome
Synonym: Cerebellooculorenal syndrome 1
Tree Number: T10.5.1.1
database_cross_reference: CHV:0000034162
database_cross_reference: CSP:0944-7801
database_cross_reference: CSP:1254-7727
database_cross_reference: DO:DOID:0110980
database_cross_reference: HPO:HP:0002335
database_cross_reference: JABL:375
database_cross_reference: MDR:10078574
database_cross_reference: MEDCIN:312974
database_cross_reference: MSH:C536293
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C74996
database_cross_reference: OMIM:213300
database_cross_reference: OMIM:613037
database_cross_reference: OMIM:MTHU000200
database_cross_reference: OMIM:MTHU039930
database_cross_reference: RCD:X77rY
database_cross_reference: SNOMEDCT_US:156895002
database_cross_reference: SNOMEDCT_US:204053001
database_cross_reference: SNOMEDCT_US:253175003
database_cross_reference: SNOMEDCT_US:716997004

Meckel syndrome
type: Class
subclass of: ciliopathy
definition: A Meckel syndrome that has_material_basis_in an autosomal recessive mutation of MKS1 on chromosome 17q22.
PMOID: PMO:00028324
Subclass_of: ciliopathy
Synonym: DYSENCEPHALIA SPLANCHNOCYSTICA
Synonym: Dysencephalia Splanchnocystica
Synonym: Dysencephalia splachnocystica
Synonym: GRUBER SYNDROME
Synonym: Gruber syndrome
Synonym: MECKEL SYNDROME
Synonym: MECKEL SYNDROME, TYPE 1
Synonym: MECKEL-GRUBER SYNDROME
Synonym: MECKEL-GRUBER SYNDROME, TYPE 1
Synonym: MES
Tree Number: T10.5.1.2
database_cross_reference: DO:DOID:0070115
database_cross_reference: MEDCIN:358438
database_cross_reference: MSH:C536133
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:249000
database_cross_reference: OMIM:609883

Opitz-GBBB syndrome
type: Class
subclass of: monogenic disease
definition: A monogenic disease that is characterized by hypertelorism, hypospadias, and additional midline defects resulting from mutations to the MID1 gene in the X-linked form or from a deletion on chromosome 22q11.2 in the autosomal dominant form.
PMOID: PMO:00028738
Subclass_of: monogenic disease
Synonym: Autosomal Dominant Opitz Syndrome (ADOS)
Synonym: BBB SYNDROME
Synonym: CHROMOSOME 22q11.2 DELETION SYNDROME, OPITZ PHENOTYPE
Synonym: Chromosome 22q11.2 Deletion Syndrome, Opitz Phenotype
Synonym: G SYNDROME
Synonym: GBBB SYNDROME
Synonym: GBBB2
Synonym: HYPERTELORISM WITH ESOPHAGEAL ABNORMALITY AND HYPOSPADIAS
Synonym: HYPERTELORISM-HYPOSPADIAS SYNDROME
Synonym: HYPOSPADIAS-DYSPHAGIA SYNDROME
Tree Number: T10.5.3.7
database_cross_reference: DO:DOID:0050780
database_cross_reference: MSH:C538387
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C125487
database_cross_reference: OMIM:145410
database_cross_reference: OMIM:614140

Ogden syndrome
type: Class
subclass of: X-linked disease
definition: An X-linked disease resulting from a deficiency in N-terminal acetyltransferase, characterized by postnatal growth failure with severe delays and dysmorphic features in boys.
PMOID: PMO:00028723
Subclass_of: X-linked disease
Synonym: N-TERMINAL ACETYLTRANSFERASE DEFICIENCY
Synonym: N-alpha-acetyltransferase
Synonym: N-terminal acetyltransferase deficiency
Synonym: NATD
Synonym: OGDEN SYNDROME
Synonym: OGDNS
Synonym: X-linked Malformation and Infantile Lethality Syndrome
Tree Number: T10.5.3.4.3
database_cross_reference: DO:DOID:0050781
database_cross_reference: OMIM:300013
database_cross_reference: OMIM:300855

Zollinger-Ellison syndrome
type: Class
subclass of: syndrome
definition: A condition in which there is increased production of gastrin by a gastrin-secreting tumor (usually located in the pancreas, duodenum, or abdominal lymph nodes) that stimulates the gastric mucosa to maximal activity, with consequent gastrointestinal mucosal ulceration.
definition: A syndrome that is haracterized by the development of a one or more tumors (gastrinoma) in the pancreas, duodenum, or both that secrete excessive levels of gastrin, a hormone that stimulates production of acid by the stomach.
PMOID: PMO:00005824
Subclass_of: syndrome
Synonym: Excessive gastrin secretion
Synonym: Gastrinoma syndrome
Synonym: PANCREATIC ULCEROGENIC TUMOR SYNDROME
Synonym: SYNDROME ZOLLINGER ELLISON
Synonym: Syndrome Zollinger Ellison
Synonym: Syndrome, Zollinger-Ellison
Synonym: Z-E SYNDROME
Synonym: Z-E syndrome
Synonym: ZE - Zollinger-Ellison syndr
Synonym: ZE - Zollinger-Ellison syndrome
Tree Number: T10.1.24
database_cross_reference: AOD:0000005601
database_cross_reference: CCPSS:0008924
database_cross_reference: CHV:0000013282
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2014-5144
database_cross_reference: CST:ULCER PEPTIC
database_cross_reference: DO:DOID:0050782
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002039
database_cross_reference: DXP:U004506
database_cross_reference: HPO:HP:0002044
database_cross_reference: ICD10CM:E16.4
database_cross_reference: LCH:U005088
database_cross_reference: LCH_NW:sh85149946
database_cross_reference: MDR:10042855
database_cross_reference: MDR:10048253
database_cross_reference: MDR:10048281
database_cross_reference: MEDCIN:30226
database_cross_reference: MSH:D015043
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:251.5
database_cross_reference: NCI:C3453
database_cross_reference: NCI_NCI-GLOSS:CDR0000044262
database_cross_reference: NDFRT:N0000003185
database_cross_reference: OMIM:MTHU036718
database_cross_reference: RCD:C1150
database_cross_reference: SNM:D-2936
database_cross_reference: SNM:D-2939
database_cross_reference: SNMI:DB-63410
database_cross_reference: SNOMEDCT_US:154694003
database_cross_reference: SNOMEDCT_US:190443003
database_cross_reference: SNOMEDCT_US:267477002
database_cross_reference: SNOMEDCT_US:53132006

peroxisomal acyl-CoA oxidase deficiency
type: Class
subclass of: peroxisomal disease
definition: A peroxisomal disease that is characterized by hypotonia and seizures in the neonatal period and neurological regression in early infancy.
PMOID: PMO:00029241
Subclass_of: peroxisomal disease
Synonym: PEROXISOMAL ACYL-CoA OXIDASE DEFICIENCY
Synonym: PSEUDONEONATAL ADRENOLEUKODYSTROPHY
Synonym: Peroxisomal ACYL-COA oxidase deficiency
Synonym: Peroxisomal acyl-coenzyme A oxidase
Synonym: Pseudoneonatal adrenoleukodystrophy
Synonym: STRAIGHT-CHAIN ACYL-CoA OXIDASE DEFICIENCY
Synonym: Straight-chain ACYL-COA oxidase deficiency
Tree Number: T10.6.2.16.4
database_cross_reference: DO:DOID:0050797
database_cross_reference: MSH:C536662
database_cross_reference: OMIM:264470
database_cross_reference: OMIM:609751

cerebral creatine deficiency syndrome
type: Class
subclass of: amino acid metabolic disorder
PMOID: PMO:00029182
Subclass_of: amino acid metabolic disorder
Tree Number: T10.6.2.15.8
database_cross_reference: DO:DOID:0050798

Matthew-Wood syndrome
type: Class
subclass of: autosomal genetic disease
definition: An autosomal genetic disease that is characterized by microphthalmia or anophthalmia, pulmonary agenesis, and diaphragmatic defect.
PMOID: PMO:00028502
Subclass_of: autosomal genetic disease
Synonym: ANOPHTHALMIA AND PULMONARY HYPOPLASIA
Synonym: ANOPHTHALMIA, CLINICAL, WITH MILD FACIAL DYSMORPHISM AND VARIABLE MALFORMATIONS OF THE LUNG, HEART, AND DIAPHRAGM
Synonym: ANOPHTHALMIA/MICROPHTHALMIA AND PULMONARY HYPOPLASIA
Synonym: Anophthalmia with pulmonary hypoplasia
Synonym: Anophthalmia with pulmonary hypoplasia syndrome
Synonym: Anophthalmia, Clinical, With Mild Facial Dysmorphism And Variable Malformations Of The Lung, Heart, And Diaphragm
Synonym: Anophthalmia-Microphthalmia And Pulmonary Hypoplasia
Synonym: MATTHEW-WOOD SYNDROME
Synonym: MCOPS9
Synonym: MICROPHTHALMIA, SYNDROMIC 9
Tree Number: T10.5.3.2.6
database_cross_reference: DO:DOID:0050819
database_cross_reference: MSH:C537768
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:601186
database_cross_reference: OMIM:610745
database_cross_reference: SNOMEDCT_US:722458000

endocardium disease
type: Class
subclass of: heart disease
definition: A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart.
PMOID: PMO:00031609
Subclass_of: heart disease
Tree Number: T10.8.3.2.1
database_cross_reference: DO:DOID:0050825

artery disease
type: Class
subclass of: vascular disease
definition: A vascular disease that is located_in an artery.
PMOID: PMO:00031861
Subclass_of: vascular disease
Synonym: 3-81-82 DISEASES OF THE ARTERIES
Synonym: Arterial Disease
Synonym: Arterial Disorder
Synonym: Arterial disease
Synonym: Arterial disease (disorder)
Synonym: Arterial disorder
Synonym: Arterial disorder NOS
Synonym: Arterial vascular disease
Synonym: Arteriopath
Synonym: Arteriopathic disease
Tree Number: T10.8.3.3.7
database_cross_reference: CHV:0000005418
database_cross_reference: CHV:0000025811
database_cross_reference: DO:DOID:0050828
database_cross_reference: MDR:10003152
database_cross_reference: MDR:10003208
database_cross_reference: MDR:10003209
database_cross_reference: MDR:10018106
database_cross_reference: MDR:10060963
database_cross_reference: MDR:10073904
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35317
database_cross_reference: RCD:XM0Al
database_cross_reference: RCD:XaBYF
database_cross_reference: SNM:D-7303
database_cross_reference: SNMI:D3-81000
database_cross_reference: SNOMEDCT_US:155413007
database_cross_reference: SNOMEDCT_US:266317000
database_cross_reference: SNOMEDCT_US:271948001
database_cross_reference: SNOMEDCT_US:359557001
database_cross_reference: SNOMEDCT_US:359560008
database_cross_reference: SNOMEDCT_US:367395004
database_cross_reference: SNOMEDCT_US:39823006
database_cross_reference: SNOMEDCT_US:77735004

pericardium disease
type: Class
subclass of: cardiovascular system disease
definition: A cardiovascular system disease that is located_in the fibrous sac surrounding the heart.
PMOID: PMO:00031599
Subclass_of: cardiovascular system disease
Tree Number: T10.8.3.1
database_cross_reference: DO:DOID:0050829

pyrimidine metabolic disorder
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder involving dysfunction of pyrimidine metabolism.
PMOID: PMO:00029245
Subclass_of: inherited metabolic disorder
Tree Number: T10.6.2.17
database_cross_reference: DO:DOID:0050832

orotic aciduria
type: Class
subclass of: pyrimidine metabolic disorder
definition: A pyrimidine metabolic disorder that is characterized by an excessive secretion of orotic acid in urine.
PMOID: PMO:00029246
Subclass_of: pyrimidine metabolic disorder
Synonym: Comb orot ac phos orot-5-phos
Synonym: Comb orot ac phosphoribosyltr & orot-5-phos decarboxyl def
Synonym: Combined orotic acid phosphoribosyltransferase and orotidine - 5 - phosphate decarboxylase deficiency
Synonym: Heredit orotic aciduria type 1
Synonym: Hereditary orotic aciduria type 1
Synonym: Hereditary orotic aciduria, type 1
Synonym: Hereditary orotic aciduria, type 1 (disorder)
Synonym: OPRT AND ODC DEFICIENCY
Synonym: OPRT AND OMP decarboxylase deficiency
Synonym: OPRT and OMP decarboxylase deficiency
Tree Number: T10.6.2.17.1
database_cross_reference: DO:DOID:0050833
database_cross_reference: MSH:C537136
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:258900
database_cross_reference: OMIM:613891
database_cross_reference: RCD:X40Us
database_cross_reference: SNMI:D6-44210
database_cross_reference: SNOMEDCT_US:69525003

CHARGE syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is acterized by a pattern of congenital anomalies including choanal atresia and malformations of the heart, inner ear, and retina.
PMOID: PMO:00025183
Subclass_of: syndrome
Synonym: Association, CHARGE
Synonym: Associations, CHARGE
Synonym: CHARGE ASSOCIATION--COLOBOMA, HEART ANOMALY, CHOANAL ATRESIA, RETARDATION, GENITAL AND EAR ANOMALIES
Synonym: CHARGE Association
Synonym: CHARGE Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital and Ear Anomalies
Synonym: CHARGE Associations
Synonym: CHARGE SYNDROME
Synonym: CHARGE Syndrome
Synonym: CHARGE Syndrome [Disease/Finding]
Synonym: CHARGE Syndromes
Tree Number: T10.1.64
database_cross_reference: CHV:0000025900
database_cross_reference: DO:DOID:0050834
database_cross_reference: MDR:10064063
database_cross_reference: MEDCIN:312753
database_cross_reference: MSH:D058747
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75100
database_cross_reference: NCI_NICHD:C75100
database_cross_reference: NDFRT:N0000182178
database_cross_reference: OMIM:214800
database_cross_reference: OMIM:608892
database_cross_reference: RCD:X00kb
database_cross_reference: SNMI:D4-01403
database_cross_reference: SNOMEDCT_US:394529000
database_cross_reference: SNOMEDCT_US:47535005

sleep apnea
type: Class
subclass of: sleep disorder
definition: A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.
PMOID: PMO:00027888
Subclass_of: sleep disorder
Synonym: Apnea Syndrome, Sleep
Synonym: Apnea Syndromes, Sleep
Synonym: Apnea syndrome
Synonym: Apnea, Sleep
Synonym: Apneas, Sleep
Synonym: Apnoea syndrome
Synonym: Breathing, Sleep-Disordered
Synonym: Hypopnea, Sleep
Synonym: Hypopneas, Sleep
Synonym: SAS - Sleep apnea syndrome
Tree Number: T10.3.1.3
database_cross_reference: AOD:0000006779
database_cross_reference: AOD:0000024039
database_cross_reference: BI:BI00560
database_cross_reference: CCPSS:0036482
database_cross_reference: CHV:0000011414
database_cross_reference: COSTAR:688
database_cross_reference: CSP:2056-7094
database_cross_reference: CSP:2596-8463
database_cross_reference: CSP:4003-0054
database_cross_reference: CST:RESPIRAT DIS
database_cross_reference: DO:DOID:0050847
database_cross_reference: DXP:U001752
database_cross_reference: HPO:HP:0010535
database_cross_reference: ICD10:G47.3
database_cross_reference: ICD10AM:G47.3
database_cross_reference: ICD10AM:G47.30
database_cross_reference: ICD10AMAE:G47.3
database_cross_reference: ICD10AMAE:G47.30
database_cross_reference: ICD10CM:G47.3
database_cross_reference: ICD10CM:G47.30
database_cross_reference: ICD9CM:780.57
database_cross_reference: ICPC2P:P06014
database_cross_reference: ICPC2P:R04011
database_cross_reference: LCH:U004340
database_cross_reference: LCH_NW:sh85123402
database_cross_reference: MDR:10040975
database_cross_reference: MDR:10040976
database_cross_reference: MDR:10040977
database_cross_reference: MDR:10040978
database_cross_reference: MDR:10040979
database_cross_reference: MDR:10040980
database_cross_reference: MDR:10053654
database_cross_reference: MDR:10055575
database_cross_reference: MEDCIN:1167
database_cross_reference: MEDCIN:270275
database_cross_reference: MEDCIN:33070
database_cross_reference: MEDLINEPLUS:2784
database_cross_reference: MSH:D012891
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26884
database_cross_reference: NCI_CTCAE:E13566
database_cross_reference: NCI_NCI-GLOSS:CDR0000532134
database_cross_reference: NCI_NICHD:C26884
database_cross_reference: NDFRT:N0000002772
database_cross_reference: OMIM:MTHU036398
database_cross_reference: PSY:47825
database_cross_reference: RCD:X0083
database_cross_reference: RCD:XaEGP
database_cross_reference: RCDAE:X0083
database_cross_reference: RCDAE:XaEGP
database_cross_reference: RCDSY:XaEGP
database_cross_reference: SNM:D-8535
database_cross_reference: SNM:F-85870
database_cross_reference: SNMI:F-28A00
database_cross_reference: SNOMEDCT_US:155614007
database_cross_reference: SNOMEDCT_US:194441007
database_cross_reference: SNOMEDCT_US:196166002
database_cross_reference: SNOMEDCT_US:206750008
database_cross_reference: SNOMEDCT_US:313246000
database_cross_reference: SNOMEDCT_US:73430006

obstructive sleep apnea
type: Class
subclass of: sleep apnea
definition: A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.
PMOID: PMO:00027891
Subclass_of: sleep apnea
Synonym: APNEA, OBSTRUCTIVE SLEEP
Synonym: Apnea, Obstructive Sleep
Synonym: Apnea, obstructive
Synonym: Apneas, Obstructive Sleep
Synonym: OBSTRUCTIVE SLEEP APNEA SYNDROME
Synonym: OSA
Synonym: OSA - Obstructive sleep apnea
Synonym: OSA - Obstructive sleep apnoea
Synonym: OSAHS
Synonym: OSAS
Tree Number: T10.3.1.3.3
database_cross_reference: CHV:0000037771
database_cross_reference: CSP:4003-0054
database_cross_reference: DO:DOID:0050848
database_cross_reference: HPO:HP:0002870
database_cross_reference: ICD10AM:G47.32
database_cross_reference: ICD10AMAE:G47.32
database_cross_reference: ICD10CM:G47.33
database_cross_reference: ICD9CM:327.23
database_cross_reference: MDR:10029983
database_cross_reference: MDR:10055577
database_cross_reference: MEDCIN:270273
database_cross_reference: MSH:D020181
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C116337
database_cross_reference: NCI:C27168
database_cross_reference: NCI_NICHD:C116337
database_cross_reference: NDFRT:N0000004021
database_cross_reference: OMIM:107650
database_cross_reference: OMIM:MTHU001467
database_cross_reference: OMIM:MTHU037141
database_cross_reference: OMIM:MTHU043402
database_cross_reference: RCD:X0084
database_cross_reference: RCDAE:X0084
database_cross_reference: SNMI:D9-74310
database_cross_reference: SNOMEDCT_US:194441007
database_cross_reference: SNOMEDCT_US:196167006
database_cross_reference: SNOMEDCT_US:78275009

renal fibrosis
type: Class
subclass of: kidney disease
PMOID: PMO:00032987
Subclass_of: kidney disease
Synonym: FIBROSIS KIDNEY
Synonym: Fibrosis kidney
Synonym: KIDNEY FIBROSIS
Synonym: Kidney fibrosis
Synonym: Renal fibrosis
Synonym: Renal fibrosis (disorder)
Synonym: fibrosis kidney
Synonym: fibrosis kidneys
Synonym: kidney fibrosis
Tree Number: T10.8.7.9.2
database_cross_reference: CHV:0000017021
database_cross_reference: CST:FIBRO KIDNEY
database_cross_reference: DO:DOID:0050855
database_cross_reference: HPO:HP:0030760
database_cross_reference: MDR:10016647
database_cross_reference: MDR:10023421
database_cross_reference: MTHICD9:587
database_cross_reference: RCD:K071.
database_cross_reference: SNOMEDCT_US:197660000

oppositional defiant disorder
type: Class
subclass of: specific developmental disorder
PMOID: PMO:00027988
Subclass_of: specific developmental disorder
Synonym: Defiant Disorder, Oppositional
Synonym: OPPOSITIONAL DEFIANT DIS
Synonym: OPPOSITIONAL DEFIANT DISORDER
Synonym: Opposition defiant disor
Synonym: Oppositional Defiant Disorder
Synonym: Oppositional defiant disorder
Synonym: Oppositional defiant disorder (diagnosis)
Synonym: Oppositional defiant disorder (disorder)
Synonym: Oppositional defiant disorder of childhood or adolescence
Synonym: defiant disorder oppositional
Tree Number: T10.3.5.1.4
database_cross_reference: CCPSS:0045223
database_cross_reference: CHV:0000008976
database_cross_reference: CSP:5003-0029
database_cross_reference: DO:DOID:0050856
database_cross_reference: DSM-5:313.81
database_cross_reference: DSM-5:F91.3
database_cross_reference: HPO:HP:0010865
database_cross_reference: ICD10:F91.3
database_cross_reference: ICD10AM:F91.3
database_cross_reference: ICD10CM:F91.3
database_cross_reference: ICD9CM:313.81
database_cross_reference: MDR:10056440
database_cross_reference: MEDCIN:32656
database_cross_reference: MEDCIN:362652
database_cross_reference: MSH:D019958
database_cross_reference: MTHICD9:313.81
database_cross_reference: NCI:C92565
database_cross_reference: PSY:35535
database_cross_reference: RCD:E2Dy0
database_cross_reference: SNMI:D9-11300
database_cross_reference: SNOMEDCT_US:18941000
database_cross_reference: SNOMEDCT_US:192601006

Marshall-Smith syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by advanced bone age, failure to thrive, respiratory problems, dysmorphic facial features, and variable mental retardation.
PMOID: PMO:00025184
Subclass_of: syndrome
Synonym: MARSHALL-SMITH SYNDROME
Synonym: MRSHSS
Synonym: Marshall-Smith syndrome (MSS)
Synonym: Marshall-Smith syndrome (disorder)
Synonym: Marshall-Weaver syndrome
Synonym: accelerated skeletal maturation, Marshall-Smith type
Synonym: marshall smith syndrome
Synonym: marshall-smith syndrome
Tree Number: T10.1.65
database_cross_reference: CHV:0000025848
database_cross_reference: CHV:0000025849
database_cross_reference: DO:DOID:0050858
database_cross_reference: JABL:650
database_cross_reference: MSH:C536026
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:164005
database_cross_reference: OMIM:602535
database_cross_reference: RCD:Xa0Zd
database_cross_reference: SNMI:D4-00502
database_cross_reference: SNOMEDCT_US:73284007

fibroma
type: Class
subclass of: cell type benign neoplasm
PMOID: PMO:00027424
Subclass_of: cell type benign neoplasm
Synonym: FIBROMA
Synonym: FIBROMA, BENIGN
Synonym: Fibroma
Synonym: Fibroma (disorder)
Synonym: Fibroma NOS
Synonym: Fibroma [Disease/Finding]
Synonym: Fibroma durum
Synonym: Fibroma, NOS
Synonym: Fibroma, no ICD-O subtype
Synonym: Fibroma, no ICD-O subtype (morphologic abnormality)
Tree Number: T10.2.3.1.16
database_cross_reference: AOD:0000004538
database_cross_reference: CCPSS:0011062
database_cross_reference: CHV:0000005030
database_cross_reference: CSP:2000-6014
database_cross_reference: DO:DOID:0050871
database_cross_reference: HPO:HP:0010614
database_cross_reference: ICD10AM:M8810/0
database_cross_reference: ICPC2P:S79001
database_cross_reference: LCH:U001784
database_cross_reference: LCH_NW:sh85048035
database_cross_reference: MDR:10016629
database_cross_reference: MDR:10016630
database_cross_reference: MDR:10045154
database_cross_reference: MSH:D005350
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3041
database_cross_reference: NCI_CDISC:C3041
database_cross_reference: NDFRT:N0000001245
database_cross_reference: OMIM:MTHU016135
database_cross_reference: RCD:BBG0.
database_cross_reference: RCD:Xa99j
database_cross_reference: RCDSY:BBG0.
database_cross_reference: SNM:M-8810/0
database_cross_reference: SNMI:M-88100
database_cross_reference: SNOMEDCT_US:112682009
database_cross_reference: SNOMEDCT_US:154627003
database_cross_reference: SNOMEDCT_US:189768006
database_cross_reference: SNOMEDCT_US:269648000
database_cross_reference: SNOMEDCT_US:424568000

pancreatic agenesis
type: Class
subclass of: pancreas disease
definition: A pancreas disease that is characterized by the failure of the pancreas to develop prior to birth.
PMOID: PMO:00033201
Subclass_of: pancreas disease
Synonym: PAGEN
Synonym: PAGEN1
Synonym: PANCREATIC AGENESIS 1
Synonym: PANCREATIC HYPOPLASIA, CONGENITAL
Synonym: partial pancreatic agenesis
Tree Number: T10.8.8.4.5
database_cross_reference: DO:DOID:0050877
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:260370
database_cross_reference: OMIM:600733

Koolen de Vries syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by developmental delay, intellectual disability, muscle weakness (hypotonia), epilepsy, distinctive facial features and congenital malformations of the heart, urogenital tract and the central nervous system, and has_physical_basis_in either a chromosome 17 (17q21.31) microdeletion or a mutation in the KANSL1-gene.
PMOID: PMO:00025176
Subclass_of: syndrome
Synonym: 17q21.31 Deletion Syndrome
Synonym: 17q21.31 Microdeletion Syndrome
Synonym: 17q21.31 microdeletion syndrome
Synonym: CHROMOSOME 17q21.31 DELETION SYNDROME
Synonym: Chromosome 17q21.31 Deletion Syndrome
Synonym: Chromosome 17q21.31 Microdeletion Syndrome
Synonym: KANSL1-related intellectual disability syndrome
Synonym: KDVS
Synonym: KOOLEN-DE VRIES SYNDROME
Synonym: KdVS
Tree Number: T10.1.57
database_cross_reference: DO:DOID:0050880
database_cross_reference: DO:DOID:0070076
database_cross_reference: MSH:C566476
database_cross_reference: OMIM:610443
database_cross_reference: OMIM:612452
database_cross_reference: SNOMEDCT_US:717338006

inclusion body myopathy with Paget disease of bone and frontotemporal dementia
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by progressive proximal muscle weakness, steolytic bone lesions consistent with Paget disease, and frontotemporal dementia and has_physical_basis_in mutation in the valosin containing protein (VCP).
PMOID: PMO:00025237
Subclass_of: syndrome
Synonym: IBMPFD
Synonym: IBMPFD - Inclusion body myopathy with early onset Paget disease and frontotemporal dementia
Synonym: IBMPFD1
Synonym: INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA
Synonym: INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA 1
Synonym: Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Synonym: Inclusion Body Myopathy with Early-Onset Paget Disease of Bone and-or Frontotemporal Dementia
Synonym: Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 1
Synonym: Inclusion Body Myopathy with Paget Disease of Bone and-or Frontotemporal Dementia
Synonym: Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia
Tree Number: T10.1.97
database_cross_reference: DO:DOID:0050881
database_cross_reference: MSH:C563476
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C122663
database_cross_reference: OMIM:167320
database_cross_reference: OMIM:601023
database_cross_reference: SNOMEDCT_US:703544004

IMAGe syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, genital abnormalities and has_physical_basis_in heterozygous mutation in the CDKN1C gene.
PMOID: PMO:00025126
Subclass_of: syndrome
Synonym: IMAGE SYNDROME
Synonym: IMAGE Syndrome
Synonym: INTRAUTERINE GROWTH RETARDATION, METAPHYSEAL DYSPLASIA, ADRENAL HYPOPLASIA CONGENITA, AND GENITAL ANOMALIES
Synonym: Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Synonym: Intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomaly syndrome
Synonym: Intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomaly syndrome (disorder)
Synonym: intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, genital abnormalities
Tree Number: T10.1.11
database_cross_reference: DO:DOID:0050885
database_cross_reference: MSH:C564543
database_cross_reference: OMIM:600856
database_cross_reference: OMIM:614732
database_cross_reference: SNOMEDCT_US:702384004

ameloblastoma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that has_material_basis_in odontogenic epithelium.
PMOID: PMO:00027322
Subclass_of: cell type benign neoplasm
Synonym: ADAMANTINOMA
Synonym: AMELOBLASTOMA
Synonym: Adamantinoma
Synonym: Ameloblastoma
Synonym: Ameloblastoma (morphologic abnormality)
Synonym: Ameloblastoma NOS
Synonym: Ameloblastoma [Disease/Finding]
Synonym: Ameloblastoma, NOS
Synonym: Ameloblastomas
Synonym: EPITHELIOMA ADAMANTINUM
Tree Number: T10.2.3.1.2
database_cross_reference: CHV:0000000986
database_cross_reference: CSP:2013-2197
database_cross_reference: DO:DOID:0050894
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000076
database_cross_reference: ICD10AM:M9310/0
database_cross_reference: MDR:10066796
database_cross_reference: MSH:D000564
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4313
database_cross_reference: NDFRT:N0000000366
database_cross_reference: RCD:BBZF.
database_cross_reference: RCD:Xa9Aj
database_cross_reference: RCDSY:BBZF.
database_cross_reference: SNM:M-9310/0
database_cross_reference: SNMI:M-93100
database_cross_reference: SNOMEDCT_US:189902002
database_cross_reference: SNOMEDCT_US:20462008

withdrawal disorder
type: Class
subclass of: substance-related disorder
definition: A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol.
PMOID: PMO:00027910
Subclass_of: substance-related disorder
Tree Number: T10.3.3.1
database_cross_reference: DO:DOID:0060001

developmental disorder of mental health
type: Class
subclass of: disease of mental health
definition: A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development.
PMOID: PMO:00027936
Subclass_of: disease of mental health
Tree Number: T10.3.5
database_cross_reference: DO:DOID:0060037

specific developmental disorder
type: Class
subclass of: developmental disorder of mental health
definition: A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.
PMOID: PMO:00027937
Subclass_of: developmental disorder of mental health
Synonym: Specific delays in development
Synonym: Specific delays in development (disorder)
Synonym: Specific developmental disorder
Synonym: Specific developmental disorder (disorder)
Synonym: Specific developmental disorder, NOS
Synonym: specific delays in development
Synonym: specific developmental disorder (diagnosis)
Synonym: specific developmental disorders
Tree Number: T10.3.5.1
database_cross_reference: AOD:0000023643
database_cross_reference: AOD:0000023646
database_cross_reference: DO:DOID:0060038
database_cross_reference: ICD9CM:315
database_cross_reference: MDR:10041428
database_cross_reference: MEDCIN:32679
database_cross_reference: RCD:E2F..
database_cross_reference: SNMI:D9-18200
database_cross_reference: SNOMEDCT_US:10720004
database_cross_reference: SNOMEDCT_US:154953009
database_cross_reference: SNOMEDCT_US:192135005
database_cross_reference: SNOMEDCT_US:268787000

pervasive developmental disorder
type: Class
subclass of: developmental disorder of mental health
PMOID: PMO:00028118
Subclass_of: developmental disorder of mental health
Synonym: Autism spectrum disorder
Synonym: Autistic continuum
Synonym: Autistic spectrum disorder
Synonym: Autistic spectrum disorder (disorder)
Synonym: Developmental disorder, pervasive
Synonym: PDD
Synonym: PPD - Pervasive devel disorder
Synonym: PPD - Pervasive developmental disorder
Synonym: Pervasive Development Disorder
Synonym: Pervasive Development Disorders
Tree Number: T10.3.5.2
database_cross_reference: AOD:0000006540
database_cross_reference: CHV:0000038288
database_cross_reference: CSP:5006-0029
database_cross_reference: ICD10:F84
database_cross_reference: ICD10:F84.9
database_cross_reference: ICD10AM:F84
database_cross_reference: ICD10AM:F84.9
database_cross_reference: ICD10CM:F84
database_cross_reference: ICD10CM:F84.9
database_cross_reference: ICD9CM:299
database_cross_reference: ICD9CM:299.9
database_cross_reference: MDR:10034739
database_cross_reference: MDR:10061345
database_cross_reference: MEDCIN:35815
database_cross_reference: MEDLINEPLUS:153
database_cross_reference: MSH:D002659
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:299.9
database_cross_reference: NCI:C97179
database_cross_reference: NCI_NICHD:C97179
database_cross_reference: OMIM:MTHU012301
database_cross_reference: OMIM:MTHU034599
database_cross_reference: PSY:38016
database_cross_reference: RCD:Eu84z
database_cross_reference: RCD:X00TM
database_cross_reference: RCDSY:Eu84z
database_cross_reference: SNMI:D9-18100
database_cross_reference: SNOMEDCT_US:192580000
database_cross_reference: SNOMEDCT_US:192588007
database_cross_reference: SNOMEDCT_US:229710003
database_cross_reference: SNOMEDCT_US:35919005
database_cross_reference: SNOMEDCT_US:367103007

autism spectrum disorder
type: Class
subclass of: pervasive developmental disorder
PMOID: PMO:00028119
Subclass_of: pervasive developmental disorder
Synonym: Autism spectrum disorder
Synonym: Autistic continuum
Synonym: Autistic spectrum disorder
Synonym: Autistic spectrum disorder (disorder)
Synonym: Developmental disorder, pervasive
Synonym: PDD
Synonym: PPD - Pervasive devel disorder
Synonym: PPD - Pervasive developmental disorder
Synonym: Pervasive Development Disorder
Synonym: Pervasive Development Disorders
Tree Number: T10.3.5.2.1
database_cross_reference: AOD:0000006540
database_cross_reference: CHV:0000038288
database_cross_reference: CSP:5006-0029
database_cross_reference: ICD10:F84
database_cross_reference: ICD10:F84.9
database_cross_reference: ICD10AM:F84
database_cross_reference: ICD10AM:F84.9
database_cross_reference: ICD10CM:F84
database_cross_reference: ICD10CM:F84.9
database_cross_reference: ICD9CM:299
database_cross_reference: ICD9CM:299.9
database_cross_reference: MDR:10034739
database_cross_reference: MDR:10061345
database_cross_reference: MEDCIN:35815
database_cross_reference: MEDLINEPLUS:153
database_cross_reference: MSH:D002659
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:299.9
database_cross_reference: NCI:C97179
database_cross_reference: NCI_NICHD:C97179
database_cross_reference: OMIM:MTHU012301
database_cross_reference: OMIM:MTHU034599
database_cross_reference: PSY:38016
database_cross_reference: RCD:Eu84z
database_cross_reference: RCD:X00TM
database_cross_reference: RCDSY:Eu84z
database_cross_reference: SNMI:D9-18100
database_cross_reference: SNOMEDCT_US:192580000
database_cross_reference: SNOMEDCT_US:192588007
database_cross_reference: SNOMEDCT_US:229710003
database_cross_reference: SNOMEDCT_US:35919005
database_cross_reference: SNOMEDCT_US:367103007

sexual disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that involves the impairment in normal sexual functioning.
PMOID: PMO:00028146
Subclass_of: disease of mental health
Synonym: Abnormal sexual function
Synonym: Abnormal sexual function (finding)
Synonym: Decreased sexual function
Synonym: Decreased sexual function (finding)
Synonym: Dysfunction;sexual
Synonym: Impaired sexual function
Synonym: SEX DYSFUNCTION
Synonym: SEXUAL DISORDER
Synonym: SEXUAL DYSFUNCTION
Synonym: SEXUAL FUNCTION ABNORMAL
Tree Number: T10.3.11
database_cross_reference: AOD:0000023510
database_cross_reference: BI:BI00466
database_cross_reference: CCPSS:0037451
database_cross_reference: CCPSS:1011989
database_cross_reference: CHV:0000011268
database_cross_reference: CHV:0000039020
database_cross_reference: COSTAR:676
database_cross_reference: CST:GUSEXDYS
database_cross_reference: CST:GYNSEX
database_cross_reference: CST:SEX FUNC ABNORM
database_cross_reference: DO:DOID:0060043
database_cross_reference: DO:DOID:1876
database_cross_reference: DSM-5:302.70
database_cross_reference: DSM-5:F52.9
database_cross_reference: ICD10CM:F52.9
database_cross_reference: ICD10CM:R37
database_cross_reference: ICPC2P:P08013
database_cross_reference: LCH_NW:sh85120728
database_cross_reference: LNC:MTHU013434
database_cross_reference: MDR:10040476
database_cross_reference: MDR:10040477
database_cross_reference: MDR:10040479
database_cross_reference: MDR:10040482
database_cross_reference: MDR:10052413
database_cross_reference: MEDCIN:314376
database_cross_reference: MEDCIN:32828
database_cross_reference: MEDCIN:36302
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:302.70
database_cross_reference: MTHICD9:302.9
database_cross_reference: NCI:C3347
database_cross_reference: NCI_NICHD:C3347
database_cross_reference: RCD:Ua1sq
database_cross_reference: RCD:X00TF
database_cross_reference: SNMI:D9-73500
database_cross_reference: SNMI:F-0B700
database_cross_reference: SNMI:F-9B222
database_cross_reference: SNOMEDCT_US:225723003
database_cross_reference: SNOMEDCT_US:231532002
database_cross_reference: SNOMEDCT_US:39894007
database_cross_reference: SNOMEDCT_US:56925008
database_cross_reference: SNOMEDCT_US:65655009

paraphilia disorder
type: Class
subclass of: sexual disorder
PMOID: PMO:00028150
Subclass_of: sexual disorder
Tree Number: T10.3.11.2
database_cross_reference: DO:DOID:0060044

Munchausen by proxy
type: Class
subclass of: factitious disorder
definition: A factitious disorder that involves a care giver's deliberate exaggeration, fabrication, and/or induce physical, psychological, behavioral, and/or mental health problems in others.
PMOID: PMO:00028145
Subclass_of: factitious disorder
Synonym: Meadow's syndrome
Synonym: Munchausen Syndrome by Proxy
Synonym: Munchausen Syndrome by Proxy [Disease/Finding]
Synonym: Munchausen syndrome by proxy
Synonym: Munchausen syndrome by proxy (disorder)
Synonym: Munchausen's by proxy
Synonym: Munchausen's by proxy (disorder)
Synonym: Münchausen syndrome by proxy
Synonym: Münchausen syndrome by proxy (disorder)
Synonym: munchausen by proxy syndrome
Tree Number: T10.3.10.1
database_cross_reference: CHV:0000015535
database_cross_reference: DO:DOID:0060045
database_cross_reference: LCH_NW:sh93000062
database_cross_reference: MDR:10028278
database_cross_reference: MEDCIN:350574
database_cross_reference: MSH:D016735
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000191013
database_cross_reference: PSY:32519
database_cross_reference: RCD:X00TE
database_cross_reference: SNMI:D9-84013
database_cross_reference: SNOMEDCT_US:394514002
database_cross_reference: SNOMEDCT_US:95637005

hypersensitivity reaction disease
type: Class
subclass of: immune system disease
definition: An immune system disease that has material basis in abnormal immune responses.
PMOID: PMO:00032703
Subclass_of: immune system disease
Tree Number: T10.8.6.3
database_cross_reference: DO:DOID:0060056

familial juvenile hyperuricemic nephropathy
type: Class
subclass of: kidney disease
definition: A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease.
PMOID: PMO:00033024
Subclass_of: kidney disease
Synonym: FAMILIAL JUVENILE HYPERURICEMIC NEPHROPATHY
Synonym: FJHN
Synonym: Fam juv hyperuricaemia nephro
Synonym: Fam juv hyperuricemia nephro
Synonym: Fam juvenile gouty nephropathy
Synonym: Familial Gout-Kidney Disease
Synonym: Familial Gouty Nephropathy
Synonym: Familial Juvenile Hyperuricemic Nephropathy
Synonym: Familial gout + renal failure
Synonym: Familial gout nephropathy
Tree Number: T10.8.7.9.8
database_cross_reference: DO:DOID:0060062
database_cross_reference: MSH:C537696
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:162000
database_cross_reference: OMIM:191845
database_cross_reference: RCD:X30Kg
database_cross_reference: RCD:X40UX
database_cross_reference: RCDAE:X40UX
database_cross_reference: SNMI:D6-40270
database_cross_reference: SNOMEDCT_US:236497009
database_cross_reference: SNOMEDCT_US:46785007

Pearson syndrome
type: Class
subclass of: mitochondrial metabolism disease
definition: A mitochondrial metabolism disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction.
PMOID: PMO:00028981
Subclass_of: mitochondrial metabolism disease
Synonym: PEARSON MARROW-PANCREAS SYNDROME
Synonym: Pearson Marrow-Pancreas Syndrome
Synonym: Pearson marrow-pancreas syndrome
Synonym: Pearson syndrome (diagnosis)
Synonym: Pearson's marrow-pancreas syndrome
Synonym: Pearson's syndrome
Synonym: Pearson's syndrome (disorder)
Tree Number: T10.6.2.1.18
database_cross_reference: DO:DOID:0060067
database_cross_reference: MDR:10062941
database_cross_reference: MEDCIN:312739
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C115326
database_cross_reference: OMIM:557000
database_cross_reference: PDQ:CDR0000285984
database_cross_reference: RCD:X40U3
database_cross_reference: SNOMEDCT_US:237985009

pre-malignant neoplasm
type: Class
subclass of: disease of cellular proliferation
definition: A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.
PMOID: PMO:00027278
Subclass_of: disease of cellular proliferation
Tree Number: T10.2.2
database_cross_reference: DO:DOID:0060071

benign neoplasm
type: Class
subclass of: disease of cellular proliferation
definition: A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize.
PMOID: PMO:00027315
Subclass_of: disease of cellular proliferation
Synonym: BENIGN NEOPL
Synonym: BENIGN NEOPLASMS
Synonym: BENIGN TUMOR
Synonym: Benign Neoplasm
Synonym: Benign Neoplasms
Synonym: Benign Tumor
Synonym: Benign Tumors
Synonym: Benign Unclassifiable Tumor
Synonym: Benign neoplasm
Synonym: Benign neoplasm NOS
Tree Number: T10.2.3
database_cross_reference: CCPSS:0061294
database_cross_reference: CHV:0000015985
database_cross_reference: COSTAR:U000008
database_cross_reference: CST:PATHTUMORBEN
database_cross_reference: DO:DOID:0060072
database_cross_reference: ICD10:D10-D36.9
database_cross_reference: ICD10:D36.9
database_cross_reference: ICD10AM:D10-D36.9
database_cross_reference: ICD10AM:D36.9
database_cross_reference: ICD10AM:M8000/0
database_cross_reference: ICD10CM:D36.9
database_cross_reference: ICD9CM:210-229.99
database_cross_reference: ICD9CM:229.9
database_cross_reference: ICPC2P:A99018
database_cross_reference: MDR:10004299
database_cross_reference: MDR:10004417
database_cross_reference: MDR:10060999
database_cross_reference: MEDCIN:98330
database_cross_reference: MEDLINEPLUS:3585
database_cross_reference: MSH:D009369
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3677
database_cross_reference: NCI_CDISC:C3677
database_cross_reference: NCI_NCI-GLOSS:CDR0000046079
database_cross_reference: PSY:05800
database_cross_reference: RCD:B7...
database_cross_reference: RCD:B7zz.
database_cross_reference: RCD:BB00.
database_cross_reference: RCD:ByuG.
database_cross_reference: RCDAE:B7...
database_cross_reference: RCDAE:BB00.
database_cross_reference: RCDSY:ByuG.
database_cross_reference: SNM:D-Y031
database_cross_reference: SNM:M-8000/0
database_cross_reference: SNMI:DF-00410
database_cross_reference: SNMI:M-80000
database_cross_reference: SNOMEDCT_US:154607004
database_cross_reference: SNOMEDCT_US:154633007
database_cross_reference: SNOMEDCT_US:189207002
database_cross_reference: SNOMEDCT_US:190189000
database_cross_reference: SNOMEDCT_US:20376005
database_cross_reference: SNOMEDCT_US:3898006

immune system cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system.
PMOID: PMO:00027105
Subclass_of: organ system cancer
Tree Number: T10.2.1.2.14
database_cross_reference: DO:DOID:0060083

cell type benign neoplasm
type: Class
subclass of: benign neoplasm
definition: A benign neoplasm that is classified by the type of cell or tissue from which it is derived.
PMOID: PMO:00027316
Subclass_of: benign neoplasm
Tree Number: T10.2.3.1
database_cross_reference: DO:DOID:0060084

organ system benign neoplasm
type: Class
subclass of: benign neoplasm
definition: A benign neoplasm that is classified by the organ system from which it is arising from.
PMOID: PMO:00027436
Subclass_of: benign neoplasm
Tree Number: T10.2.3.2
database_cross_reference: DO:DOID:0060085

endocrine organ benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.
PMOID: PMO:00027437
Subclass_of: organ system benign neoplasm
Tree Number: T10.2.3.2.1
database_cross_reference: DO:DOID:0060089

cardiovascular organ benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.
PMOID: PMO:00027674
Subclass_of: organ system benign neoplasm
Tree Number: T10.2.3.2.9
database_cross_reference: DO:DOID:0060091

immune system organ benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm located_in the immune system organs.
PMOID: PMO:00027581
Subclass_of: organ system benign neoplasm
Tree Number: T10.2.3.2.6
database_cross_reference: DO:DOID:0060092

thoracic benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplam that is located_in the thoracic cavity.
PMOID: PMO:00027626
Subclass_of: organ system benign neoplasm
Synonym: Benign Neoplasm of Thorax
Synonym: Benign Neoplasm of the Thorax
Synonym: Benign Thoracic Neoplasm
Synonym: Benign Thoracic Tumor
Synonym: Benign Tumor of Thorax
Synonym: Benign Tumor of the Thorax
Synonym: Benign neoplasm of thorax
Synonym: Benign neoplasm of thorax (disorder)
Synonym: Benign tumor of thorax
Synonym: Benign tumor of thorax (disorder)
Tree Number: T10.2.3.2.8
database_cross_reference: DO:DOID:0060097
database_cross_reference: MTHICD9:229.8
database_cross_reference: NCI:C4565
database_cross_reference: RCD:X78eM
database_cross_reference: RCDAE:X78eM
database_cross_reference: SNOMEDCT_US:255059002

musculoskeletal system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm that is located_in the muscular and skeletal organs.
PMOID: PMO:00027558
Subclass_of: organ system benign neoplasm
Tree Number: T10.2.3.2.4
database_cross_reference: DO:DOID:0060099

musculoskeletal system cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs.
PMOID: PMO:00026914
Subclass_of: organ system cancer
Synonym: skeletal system cancer
Tree Number: T10.2.1.2.13
database_cross_reference: DO:DOID:0060100

benign glioma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that has_material_basis_in glial cells.
PMOID: PMO:00027402
Subclass_of: cell type benign neoplasm
Synonym: Gliomas benign
Synonym: gliomas benign
Tree Number: T10.2.3.1.10
database_cross_reference: CHV:0000050073
database_cross_reference: DO:DOID:0060101
database_cross_reference: MDR:10018339

nervous system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.
PMOID: PMO:00027686
Subclass_of: organ system benign neoplasm
Synonym: Benign Neoplasm of Nervous System
Synonym: Benign Neoplasm of the Nervous System
Synonym: Benign Nervous System Neoplasm
Synonym: Benign Nervous System Tumor
Synonym: Benign Tumor of Nervous System
Synonym: Benign Tumor of the Nervous System
Synonym: Benign neo nerv sys NOS
Synonym: Benign neopl. nervous system
Synonym: Benign neopl.nervous syst. NOS
Synonym: Benign neoplasm nervous system
Tree Number: T10.2.3.2.10
database_cross_reference: DO:DOID:0060115
database_cross_reference: ICD9CM:225
database_cross_reference: ICD9CM:225.9
database_cross_reference: ICPC2EENG:N75
database_cross_reference: MDR:10004307
database_cross_reference: MDR:10004353
database_cross_reference: MDR:10004427
database_cross_reference: MDR:10029207
database_cross_reference: MDR:10029209
database_cross_reference: MDR:10061283
database_cross_reference: MEDCIN:99787
database_cross_reference: MEDLINEPLUS:3585
database_cross_reference: MTH:U001552
database_cross_reference: MTHICD9:225.9
database_cross_reference: NCI:C4789
database_cross_reference: RCD:B7Fz.
database_cross_reference: RCD:X78rr
database_cross_reference: RCD:XE2va
database_cross_reference: RCDAE:X78rr
database_cross_reference: SNMI:DA-F0000
database_cross_reference: SNOMEDCT_US:189160006
database_cross_reference: SNOMEDCT_US:189173005
database_cross_reference: SNOMEDCT_US:271478002
database_cross_reference: SNOMEDCT_US:92247009

peritoneal benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm that is located_in the serous membrane lining the abdominal cavity or coelom.
PMOID: PMO:00027579
Subclass_of: organ system benign neoplasm
Tree Number: T10.2.3.2.5
database_cross_reference: DO:DOID:0060117

thoracic disease
type: Class
subclass of: disease of anatomical entity
definition: A disease of anatomical entity that is located_in the thoracic cavity.
PMOID: PMO:00033246
Subclass_of: disease of anatomical entity
Synonym: Disease of thorax
Synonym: Disease of thorax (disorder)
Synonym: Disease, Thoracic
Synonym: Diseases, Thoracic
Synonym: Disorder of thorax
Synonym: Disorder of thorax (disorder)
Synonym: THORACIC DIS
Synonym: Thoracic Disease
Synonym: Thoracic Diseases
Synonym: Thoracic Diseases [Disease/Finding]
Tree Number: T10.8.9
database_cross_reference: CHV:0000012202
database_cross_reference: DO:DOID:0060118
database_cross_reference: MEDCIN:276403
database_cross_reference: MSH:D013896
database_cross_reference: NCI:C35742
database_cross_reference: NDFRT:N0000002925
database_cross_reference: SNOMEDCT_US:118946009

integumentary system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm located_in the integumentary system organs.
PMOID: PMO:00027466
Subclass_of: organ system benign neoplasm
Tree Number: T10.2.3.2.2
database_cross_reference: DO:DOID:0060121

integumentary system cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer that is located_in the skin, hair and nails.
PMOID: PMO:00026732
Subclass_of: organ system cancer
Tree Number: T10.2.1.2.11
database_cross_reference: DO:DOID:0060122

acquired metabolic disease
type: Class
subclass of: disease of metabolism
definition: A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.
PMOID: PMO:00028839
Subclass_of: disease of metabolism
Tree Number: T10.6.1
database_cross_reference: DO:DOID:0060158

organic acidemia
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids.
PMOID: PMO:00029199
Subclass_of: amino acid metabolic disorder
Synonym: Organic acidemias
Synonym: organic acid metabolism disorder
Synonym: organic acidemias
Synonym: organic acidemias (diagnosis)
Synonym: organic aciduria
Tree Number: T10.6.2.15.21
database_cross_reference: DO:DOID:0060159
database_cross_reference: LNC:LP56747-6
database_cross_reference: LNC:MTHU021579
database_cross_reference: MEDCIN:312766

body dysmorphic disorder
type: Class
subclass of: somatoform disorder
definition: A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image).
PMOID: PMO:00028130
Subclass_of: somatoform disorder
Synonym: BODY IMAGE DISORDER
Synonym: Body Dysmorphic Disorder
Synonym: Body Dysmorphic Disorders
Synonym: Body Dysmorphic Disorders [Disease/Finding]
Synonym: Body Image Disfunction
Synonym: Body Image Disfunctions
Synonym: Body Image Disorder
Synonym: Body Image Disorders
Synonym: Body dysmorphic disorder
Synonym: Body dysmorphic disorder (disorder)
Tree Number: T10.3.6.5
database_cross_reference: CHV:0000002040
database_cross_reference: CST:DEPERSONAL
database_cross_reference: DO:DOID:0060163
database_cross_reference: DSM-5:300.7
database_cross_reference: DSM-5:F45.22
database_cross_reference: ICD10CM:F45.22
database_cross_reference: LCH_NW:sh96000257
database_cross_reference: MDR:10005892
database_cross_reference: MDR:10013193
database_cross_reference: MDR:10013484
database_cross_reference: MDR:10013485
database_cross_reference: MDR:10049096
database_cross_reference: MDR:10052793
database_cross_reference: MEDCIN:1304
database_cross_reference: MEDCIN:35800
database_cross_reference: MSH:D057215
database_cross_reference: MTHICD9:300.7
database_cross_reference: NDFRT:N0000181016
database_cross_reference: PSY:06427
database_cross_reference: PSY:15640
database_cross_reference: RCD:Xa0lG
database_cross_reference: RCD:XaEG0
database_cross_reference: SNMI:D9-82020
database_cross_reference: SNOMEDCT_US:313224008
database_cross_reference: SNOMEDCT_US:83482000

pain disorder
type: Class
subclass of: somatoform disorder
definition: A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.
PMOID: PMO:00028128
Subclass_of: somatoform disorder
Synonym: PAIN DIS
Synonym: PAIN SYNDROME
Synonym: Pain Disorder
Synonym: Pain Disorders
Synonym: Pain disease or syndrome
Synonym: disorder pain
Synonym: disorders pain
Synonym: pain disorders
Synonym: pain syndrome
Synonym: pain syndromes
Tree Number: T10.3.6.3
database_cross_reference: CCPSS:0045023
database_cross_reference: CHV:0000031997
database_cross_reference: DO:DOID:0060164
database_cross_reference: MEDCIN:311894
database_cross_reference: MSH:D013001
database_cross_reference: PSY:36155
database_cross_reference: SNM:D-8210
database_cross_reference: SNM:NOCODE

Kleine-Levin syndrome
type: Class
subclass of: recurrent hypersomnia
definition: A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior.
PMOID: PMO:00027896
Subclass_of: recurrent hypersomnia
Synonym: Hibernation Syndrome, Kleine-Levin
Synonym: Hypersomnia, Periodic
Synonym: Hypersomnia-bulimia syndrome
Synonym: KLEINE-LEVIN HIBERNATION SYNDROME
Synonym: KLEINE-LEVIN SYNDROME
Synonym: Kleine Levin Critchley Syndrome
Synonym: Kleine Levin Hibernation Syndrome
Synonym: Kleine Levin Syndrome
Synonym: Kleine Levin syndrome
Synonym: Kleine Levin syndrome (diagnosis)
Tree Number: T10.3.1.7.1
database_cross_reference: CHV:0000020802
database_cross_reference: DO:DOID:0060165
database_cross_reference: ICD10CM:G47.13
database_cross_reference: MDR:10053712
database_cross_reference: MDR:10053742
database_cross_reference: MEDCIN:30267
database_cross_reference: MSH:D017593
database_cross_reference: MTHICD9:327.13
database_cross_reference: NCI:C84800
database_cross_reference: NDFRT:N0000003612
database_cross_reference: OMIM:148840
database_cross_reference: PSY:27415
database_cross_reference: RCD:X008E
database_cross_reference: SNM:D-8528
database_cross_reference: SNMI:D9-74270
database_cross_reference: SNOMEDCT_US:111488004

gamma-amino butyric acid metabolism disorder
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway.
PMOID: PMO:00029178
Subclass_of: amino acid metabolic disorder
Tree Number: T10.6.2.15.7
database_cross_reference: DO:DOID:0060176

CREST syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by calcinosis, Raynaud's phenomeno, esophageal dysmotility, sclerodactyly and telangiectasia.
PMOID: PMO:00025228
Subclass_of: syndrome
Synonym: CR(E)ST syndrome
Synonym: CREST
Synonym: CREST - Calc, Raynaud, sclerodact, oesoph, telangiect
Synonym: CREST - Calc,Rayn phen,oesoph dysf,sclerodact,telangiectasia
Synonym: CREST - Calc/Rayn/scl/oes/tel
Synonym: CREST - Calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia
Synonym: CREST - Calcinosis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly, telangiectasia
Synonym: CREST - Calcinosis, Raynaud's phenomenon, sclerodactyly, esophageal involvement, telangiectasia syndrome
Synonym: CREST - Calcinosis, Raynaud's phenomenon, sclerodactyly, oesophageal involvement, telangiectasia syndrome
Synonym: CREST SYNDROME
Tree Number: T10.1.92
database_cross_reference: CCPSS:0059182
database_cross_reference: CHV:0000020818
database_cross_reference: COSTAR:U000018
database_cross_reference: CSP:4008-0097
database_cross_reference: DO:DOID:0060218
database_cross_reference: DRUGBANK:DB09325
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000416
database_cross_reference: ICD10:M34.1
database_cross_reference: ICD10AM:M34.1
database_cross_reference: ICD10CM:M34.1
database_cross_reference: ICPC2P:A99013
database_cross_reference: MDR:10011380
database_cross_reference: MEDCIN:36098
database_cross_reference: MSH:D017675
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C70646
database_cross_reference: NCI_NICHD:C70646
database_cross_reference: NDFRT:N0000003618
database_cross_reference: OMIM:181750
database_cross_reference: RCD:X7051
database_cross_reference: RCDAE:X7051
database_cross_reference: SNMI:D1-10240
database_cross_reference: SNOMEDCT_US:156453002
database_cross_reference: SNOMEDCT_US:201442004
database_cross_reference: SNOMEDCT_US:31848007

Maffucci syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.
PMOID: PMO:00025241
Subclass_of: syndrome
Synonym: Chondrodysplasia with Hemangioma
Synonym: Chondrodysplasia with haemangioma
Synonym: Chondrodysplasia with hemangioma
Synonym: Chondrodysplasia+haemangioma
Synonym: Chondrodysplasia+hemangioma
Synonym: Chondroplasia Angiomatosis
Synonym: Chondroplasia angiomatosis
Synonym: Congenital multiple enchondromata with haemangioma (& [Kast's syndrome])
Synonym: Congenital multiple enchondromata with haemangioma (& [Kast's syndrome]) (disorder)
Synonym: Congenital multiple enchondromata with hemangioma (& [Kast's syndrome])
Tree Number: T10.1.101
database_cross_reference: CHV:0000007658
database_cross_reference: DO:DOID:0060221
database_cross_reference: DO:DOID:4624
database_cross_reference: ICD10CM:Q78.4
database_cross_reference: MEDCIN:314871
database_cross_reference: MSH:D004687
database_cross_reference: NCI:C3213
database_cross_reference: OMIM:614569
database_cross_reference: RCD:XE1M9
database_cross_reference: RCDAE:XE1M9
database_cross_reference: SNM:D-5416
database_cross_reference: SNMI:D4-01031
database_cross_reference: SNOMEDCT_US:205470006
database_cross_reference: SNOMEDCT_US:234135008
database_cross_reference: SNOMEDCT_US:46041001

3MC syndrome
type: Class
subclass of: syndrome
definition: A 3MC syndrome that has_material_basis_in a compound heterozygous mutation in the COLEC10 gene on chromosome 8q24.
PMOID: PMO:00025191
Subclass_of: syndrome
Synonym: 3MC SYNDROME 3
Synonym: 3MC syndrome 3
Synonym: 3MC3
Synonym: FACIAL CLEFTING SYNDROME, GYPSY TYPE
Synonym: Facial clefting syndrome, Gypsy type
Synonym: MALPUECH FACIAL CLEFTING SYNDROME, FORMERLY
Synonym: Malpuech facial clefting syndrome
Synonym: Malpuech syndrome
Synonym: craniofacial-ulnar-renal syndrome
Synonym: facial clefting syndrome, Gypsy type
Tree Number: T10.1.72
database_cross_reference: DO:DOID:0060225
database_cross_reference: DO:DOID:0060577
database_cross_reference: JABL:413
database_cross_reference: MSH:C535704
database_cross_reference: OMIM:248340

Adams-Oliver syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by defects of the scalp (aplasia cutis congenita), abnormalities of the fingers, toes, arms and legs.
PMOID: PMO:00025168
Subclass_of: syndrome
Synonym: ABSENCE DEFECT OF LIMBS, SCALP, AND SKULL
Synonym: ADAMS-OLIVER SYNDROME 1
Synonym: AOS
Synonym: AOS1
Synonym: APLASIA CUTIS CONGENITA WITH TERMINAL TRANSVERSE LIMB DEFECTS
Synonym: Absence defect of limbs, scalp, and skull
Synonym: Adams Oliver syndrome
Synonym: Adams-Oliver syndrome (disorder)
Synonym: Adams-Oliver syndrome 1
Synonym: Aplasia Cutis Congenita With Terminal Transverse Limb Defects
Tree Number: T10.1.49
database_cross_reference: CHV:0000025875
database_cross_reference: DO:DOID:0060227
database_cross_reference: JABL:11
database_cross_reference: MSH:C538225
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:100300
database_cross_reference: OMIM:610911
database_cross_reference: RCD:X50Kh
database_cross_reference: SNMI:D4-00913
database_cross_reference: SNOMEDCT_US:34748004

Baraitser-Winter syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by distinctive facial features including hypertelorism, large eyelid openings, ptosis, high-arched eyebrows, a broad nasal bridge and tip of the nose, a long space between the nose and the upper lip, full cheeks and a pointed chin; structural abnormalities of the brain might also be present.
PMOID: PMO:00025181
Subclass_of: syndrome
Synonym: BARAITSER-WINTER SYNDROME 1
Synonym: BRWS1
Synonym: CEREBROFRONTOFACIAL SYNDROME
Synonym: CEREBROOCULOFACIAL LYMPHATIC SYNDROME
Synonym: COFLS
Synonym: Cerebro-frontofacial syndrome, type 3
Synonym: FRYNS-AFTIMOS SYNDROME
Synonym: Fryns-Aftimos syndrome
Synonym: IRIS COLOBOMA WITH PTOSIS, HYPERTELORISM, AND MENTAL RETARDATION
Synonym: Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation
Tree Number: T10.1.62
database_cross_reference: DO:DOID:0060229
database_cross_reference: JABL:47
database_cross_reference: MSH:C565462
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:102630
database_cross_reference: OMIM:243310
database_cross_reference: SNOMEDCT_US:702410002

Bruck syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by a combination of multiple joint contractures and osteogenesis imperfecta.
PMOID: PMO:00025224
Subclass_of: syndrome
Synonym: BRKS1
Synonym: BRUCK SYNDROME 1
Synonym: Bruck syndrome 1
Synonym: Osteogenesis imperfecta with congenital joint contractures
Synonym: osteogenesis imperfecta with congenital joint contractures
Tree Number: T10.1.88
database_cross_reference: DO:DOID:0060231
database_cross_reference: MSH:C537406
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:259450
database_cross_reference: OMIM:607063

branchiootic syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by malformations of the outer, middle and inner ear and branchial and renal malformations. Mutations of the EYA1, SIX1 and SIX5 genes are associated with the syndrome.
PMOID: PMO:00025172
Subclass_of: syndrome
Synonym: BO SYNDROME 2
Synonym: BO Syndrome 2
Synonym: BO syndrome
Synonym: BOR
Synonym: BOS2
Synonym: BRANCHIOOTIC SYNDROME 2
Synonym: Branchiootic Syndrome 2
Synonym: branchiootic dysplasia
Tree Number: T10.1.53
database_cross_reference: DO:DOID:0060232
database_cross_reference: MSH:C565171
database_cross_reference: OMIM:120502

cardiofaciocutaneous syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by unusually sparse, brittle, curly hair, macrocephaly, a prominent forehead and bi-temporal narrowing, intellectual disability, failure to thrive, congenital heart defects, short stature and skin abnormalities; it is that has material basis in mutation in the BRAF, MAP2K1, MAP2kK2 and KRAS genes.
PMOID: PMO:00025239
Subclass_of: syndrome
Synonym: CARDIOFACIOCUTANEOUS SYNDROME 1
Synonym: CFC
Synonym: CFC SYNDROME
Synonym: CFC syndrome
Synonym: CFC1
Synonym: CFCS
Synonym: Cardio-Facio-Cutaneous Syndrome
Synonym: Cardio-facio-cutaneous syndrome
Synonym: Cardio-facio-cutaneous syndrome (disorder)
Synonym: Cardiofaciocutaneous (CFC) Syndrome
Tree Number: T10.1.99
database_cross_reference: DO:DOID:0060233
database_cross_reference: JABL:87
database_cross_reference: MSH:C535579
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84617
database_cross_reference: OMIM:115150
database_cross_reference: OMIM:164757
database_cross_reference: SNOMEDCT_US:403770008

carnitine palmitoyltransferase II deficiency
type: Class
subclass of: lipid metabolism disorder
definition: A lipid metabolism disorder characterized by an enzymatic defect that prevents long-chain fatty acids from being transported into the mitochondria.
PMOID: PMO:00029280
Subclass_of: lipid metabolism disorder
Synonym: CPT II Deficiency
Synonym: CPT-II
Synonym: CPT2 - Carnitine palmitoyltransferase II deficiency
Synonym: CPT2-Carn palmitoyltran II def
Synonym: CPTII - Carnitine palmitoyltransferase deficiency type II
Synonym: CPTII-Carn palmitoyltre def II
Synonym: Carnit palmitoyltransf II def
Synonym: Carnitine Palmitoyltransferase 2 Deficiency
Synonym: Carnitine Palmitoyltransferase II Deficiency
Synonym: Carnitine Palmitoyltransferase Ii Deficiency
Tree Number: T10.6.2.18.11
database_cross_reference: DO:DOID:0060235
database_cross_reference: LNC:LA12486-9
database_cross_reference: MSH:C535589
database_cross_reference: NCI:C114766
database_cross_reference: RCD:X40UR
database_cross_reference: SNOMEDCT_US:238002005

xanthinuria
type: Class
subclass of: purine-pyrimidine metabolic disorder
definition: A purine-pyrimidine metabolic disorder characterized by deficiency of xanthine oxidase, resulting in excretion of large amounts of xanthine in the urine and the formation of xanthine stones.
PMOID: PMO:00029163
Subclass_of: purine-pyrimidine metabolic disorder
Synonym: Classical xanthinuria
Synonym: Deficiency of hypoxanthine oxidase
Synonym: Deficiency of xanthine oxidase
Synonym: Deficiency of xanthine oxidase (disorder)
Synonym: Hereditary xanthinuria type 1
Synonym: Hereditary xanthinuria, type I
Synonym: Isolated xanthine oxidase deficiency
Synonym: Isolated xanthine oxidase deficiency (disorder)
Synonym: XAN1
Synonym: XANTHINE DEHYDROGENASE DEFICIENCY
Tree Number: T10.6.2.14.1
database_cross_reference: DO:DOID:0060236
database_cross_reference: HPO:HP:0003534
database_cross_reference: MSH:C562584
database_cross_reference: OMIM:278300
database_cross_reference: OMIM:607633
database_cross_reference: RCD:X30Kc
database_cross_reference: SNMI:D6-40510
database_cross_reference: SNOMEDCT_US:124147007
database_cross_reference: SNOMEDCT_US:72682008

Van Maldergem syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by facial abnormalities such as telecanthus, epicanthus, broad flattened nose, large inverted W-shaped mouth and malformed ears, malformed extremities such as camptodactyly, clinodactyly, interdigital webbing and joint hyperlaxity and mental retardation.
PMOID: PMO:00025127
Subclass_of: syndrome
Synonym: CEREBROFACIOARTICULAR SYNDROME
Synonym: Cerebro-facio-articular syndrome
Synonym: Cerebro-facio-articular syndrome of Van Maldergem
Synonym: Cerebrofacioarticular syndrome
Synonym: VAN MALDERGEM SYNDROME 1
Synonym: VMLDS1
Synonym: Van Maldergem Wetzburger Verloes syndrome
Synonym: cerebro-facio-articular syndrome
Tree Number: T10.1.12
database_cross_reference: DO:DOID:0060238
database_cross_reference: MSH:C536530
database_cross_reference: OMIM:601390
database_cross_reference: OMIM:603057

Van der Woude syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by the combination of lower lip pits, cleft lip with or without cleft palate and cleft palate alone.
PMOID: PMO:00025151
Subclass_of: syndrome
Synonym: CLEFT LIP AND/OR PALATE WITH MUCOUS CYSTS OF LOWER LIP
Synonym: Cleft lip and-or palate with mucous cysts of lower lip
Synonym: LIP-PIT SYNDROME
Synonym: LPS
Synonym: Lip pit syndrome
Synonym: Lip-Pit Syndrome
Synonym: Lip-pit, cleft lip syndrome
Synonym: Lip-pit-cleft lip syndrome
Synonym: PIT
Synonym: VAN DER WOUDE SYNDROME 1
Tree Number: T10.1.33
database_cross_reference: CHV:0000018175
database_cross_reference: CSP:0725-7823
database_cross_reference: CSP:0944-7801
database_cross_reference: CSP:2483-6315
database_cross_reference: DO:DOID:0060239
database_cross_reference: ICD10CM:Q38.0
database_cross_reference: MEDCIN:338724
database_cross_reference: MSH:C536528
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C74986
database_cross_reference: NCI_NICHD:C74986
database_cross_reference: OMIM:119300
database_cross_reference: OMIM:607199
database_cross_reference: SNM:D-5115
database_cross_reference: SNMI:D4-00704
database_cross_reference: SNOMEDCT_US:79261008

Simpson-Golabi-Behmel syndrome
type: Class
subclass of: X-linked disease
definition: An X-linked disease characterized by pre- and postnatal overgrowth and craniofacial, skeletal, cardiac and renal abnormalities.
PMOID: PMO:00028729
Subclass_of: X-linked disease
Synonym: BULLDOG SYNDROME
Synonym: Bulldog syndrome
Synonym: DGSX
Synonym: DGSX Golabi-Rosen syndrome
Synonym: DYSPLASIA GIGANTISM SYNDROME, X-LINKED
Synonym: Dysplasia gigantism syndrome, X-linked
Synonym: GOLABI-ROSEN SYNDROME
Synonym: Golabi-Rosen syndrome
Synonym: Golabi-Rosen syndrome (GRS)
Synonym: Mental Retardation-Overgrowth Syndrome
Tree Number: T10.5.3.4.9
database_cross_reference: CHV:0000048964
database_cross_reference: DO:DOID:0060248
database_cross_reference: JABL:594
database_cross_reference: MSH:C537340
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118787
database_cross_reference: OMIM:300037
database_cross_reference: OMIM:312870
database_cross_reference: SNOMEDCT_US:439143004

Robinow syndrome
type: Class
subclass of: syndrome
definition: A Robinow syndrome characterized by autosomal dominant inheritance of dysmorphic features resembling a fetal face, mesomelic limb shortening, hypoplastic external genitalia in males, and renal and vertebral anomalies that has_material_basis_in heterozygous mutation in the WNT5A gene on chromosome 3p.
PMOID: PMO:00025140
Subclass_of: syndrome
Synonym: ACRAL DYSOSTOSIS WITH FACIAL AND GENITAL ABNORMALITIES
Synonym: Acral Dysostosis with Facial and Genital Abnormalities
Synonym: DRS1
Synonym: FETAL FACE SYNDROME
Synonym: Fetal Face Syndrome
Synonym: Fetal face syndrome
Synonym: Foetal face syndrome
Synonym: Mesomelic Dwarfism-Small Genitalia Syndrome
Synonym: ROBINOW DWARFISM
Synonym: ROBINOW SYNDROME, AUTOSOMAL DOMINANT 1
Tree Number: T10.1.26
database_cross_reference: CHV:0000025847
database_cross_reference: DO:DOID:0060254
database_cross_reference: DO:DOID:0060766
database_cross_reference: ICD10CM:Q87.1
database_cross_reference: JABL:562
database_cross_reference: MSH:C562492
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85048
database_cross_reference: OMIM:164975
database_cross_reference: OMIM:180700
database_cross_reference: RCD:PKy67
database_cross_reference: SNM:D-5043
database_cross_reference: SNMI:D4-00304
database_cross_reference: SNOMEDCT_US:76520005

renal-hepatic-pancreatic dysplasia
type: Class
subclass of: physical disorder
PMOID: PMO:00028282
Subclass_of: physical disorder
Synonym: RENAL-HEPATIC-PANCREATIC DYSPLASIA
Synonym: Renal-Hepatic-Pancreatic Dysplasia
Tree Number: T10.4.19
database_cross_reference: MSH:C567142
database_cross_reference: MTH:NOCODE

gallbladder disease
type: Class
subclass of: gastrointestinal system disease
definition: A gastrointestinal system disease that is located_in the gallbladder.
PMOID: PMO:00033632
Subclass_of: gastrointestinal system disease
Synonym: BILIARY DISEASE
Synonym: Biliary disease
Synonym: Bladder Disease, Gall
Synonym: Bladder Diseases, Gall
Synonym: DISEASE GALLBLADDER
Synonym: Dis of gallbladder NOS
Synonym: Disease gallbladder
Synonym: Disease of gallbladder
Synonym: Disease of gallbladder (disorder)
Synonym: Disease of gallbladder, NOS
Tree Number: T10.8.11.10
database_cross_reference: CCPSS:0033110
database_cross_reference: CCPSS:0058461
database_cross_reference: CHV:0000005323
database_cross_reference: CHV:0000047276
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0413-4647
database_cross_reference: CST:CHOLECYST
database_cross_reference: CST:DIG/GB
database_cross_reference: DO:DOID:0060262
database_cross_reference: ICD10:K82.9
database_cross_reference: ICD10AM:K82.9
database_cross_reference: ICD10CM:K82.9
database_cross_reference: ICD9CM:575.9
database_cross_reference: LCH_NW:sh85052805
database_cross_reference: MDR:10013103
database_cross_reference: MDR:10017625
database_cross_reference: MDR:10017626
database_cross_reference: MDR:10017627
database_cross_reference: MDR:10017628
database_cross_reference: MDR:10017641
database_cross_reference: MDR:10045789
database_cross_reference: MEDCIN:30261
database_cross_reference: MEDLINEPLUS:259
database_cross_reference: MSH:D005705
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34631
database_cross_reference: NDFRT:N0000001304
database_cross_reference: RCD:X3088
database_cross_reference: RCD:XE0dN
database_cross_reference: SNM:D-6370
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D5-85000
database_cross_reference: SNOMEDCT_US:155807008
database_cross_reference: SNOMEDCT_US:155826000
database_cross_reference: SNOMEDCT_US:155829007
database_cross_reference: SNOMEDCT_US:266535008
database_cross_reference: SNOMEDCT_US:266542008
database_cross_reference: SNOMEDCT_US:266543003
database_cross_reference: SNOMEDCT_US:39621005

peeling skin syndrome
type: Class
subclass of: skin disease
PMOID: PMO:00033961
Subclass_of: skin disease
Synonym: DECIDUOUS SKIN
Synonym: Deciduous Skin
Synonym: KERATOLYSIS EXFOLIATIVA CONGENITA
Synonym: Keratolysis Exfoliativa Congenita
Synonym: PEELING SKIN SYNDROME
Synonym: PSS
Synonym: Peeling Skin Syndrome
Synonym: Peeling skin syndrome 1
Synonym: SKIN PEELING, FAMILIAL CONTINUOUS GENERALIZED
Synonym: Skin Peeling, Familial Continuous Generalized
Tree Number: T10.8.12.2.41
database_cross_reference: DO:DOID:0060283
database_cross_reference: MSH:C564818
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:270300

parietal foramina
type: Class
subclass of: neural tube defect
PMOID: PMO:00028271
Subclass_of: neural tube defect
Synonym: CATLIN MARKS
Synonym: CRANIUM BIFIDUM OCCULTUM
Synonym: CRANIUM BIFIDUM, HEREDITARY
Synonym: Caitlin marks
Synonym: Catlin Marks
Synonym: Catlin marks
Synonym: Cranium Bifidum Occultum
Synonym: Cranium Bifidum, Hereditary
Synonym: Cranium bifidum occultum
Synonym: Enlarged Parietal Foramina
Tree Number: T10.4.16.1
database_cross_reference: DO:DOID:0060285
database_cross_reference: HPO:HP:0004423
database_cross_reference: MSH:C566826
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:168500
database_cross_reference: OMIM:MTHU015760
database_cross_reference: OMIM:MTHU018093
database_cross_reference: SNOMEDCT_US:718099006

combined oxidative phosphorylation deficiency
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028966
Subclass_of: mitochondrial metabolism disease
Synonym: COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 6
Synonym: COXPD6
Synonym: ENCEPHALOMYOPATHY, MITOCHONDRIAL, X-LINKED
Tree Number: T10.6.2.1.3
database_cross_reference: DO:DOID:0060286
database_cross_reference: OMIM:300169
database_cross_reference: OMIM:300816

Ohdo syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by blepharophimosis, ptosis, dental hypoplasia, hearing impairment and intellectual disability.
PMOID: PMO:00025154
Subclass_of: syndrome
Synonym: Blepharophimosis syndrome Ohdo type
Synonym: MENTAL RETARDATION, CONGENITAL HEART DISEASE, BLEPHAROPHIMOSIS, BLEPHAROPTOSIS, AND HYPOPLASTIC TEETH
Synonym: Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth
Synonym: Mental retardation, congenital heart disease, blepharophimosis, blepharoptosis and hypoplastic teeth
Synonym: Mental retardation, congenital heart disease, blepharophimosis, blepharoptosis and hypoplastic teeth (disorder)
Synonym: OHDO BLEPHAROPHIMOSIS SYNDROME
Synonym: OHDO SYNDROME
Synonym: Ohdo Blepharophimosis syndrome
Synonym: Ohdo Madokoro Sonoda syndrome
Synonym: Ohdo blepharophimosis syndrome
Tree Number: T10.1.36
database_cross_reference: DO:DOID:0060289
database_cross_reference: JABL:496
database_cross_reference: MEDCIN:355911
database_cross_reference: MSH:C536232
database_cross_reference: OMIM:249620
database_cross_reference: SNOMEDCT_US:412787009

blepharophimosis-intellectual disability syndrome, SBBYS type
type: Class
subclass of: Ohdo syndrome
PMOID: PMO:00025155
Subclass_of: Ohdo syndrome
Synonym: Blepharophimosis and Mental Retardation Syndrome, Say-Barber-Biesecker-Young-Simpson Type
Synonym: Blepharophimosis-Intellectual Deficit Syndrome, Say-Barber-Biesecker-Young-Simpson Type
Synonym: Blepharophimosis-intellectual deficit syndrome, Say-Barber/Biesecker/Young-Simpson type
Synonym: Blepharophimosis-mental retardation syndrome, Say-Barber-Biesecker-Young-Simpson type
Synonym: Blepharophimosis-mental retardation syndrome, Say-Barber-Biesecker-Young-Simpson type (disorder)
Synonym: Mental retardation unusual facies hypothyroidism
Synonym: OHDO SYNDROME, SBBYS VARIANT
Synonym: Ohdo Syndrome, SBBYS Variant
Synonym: Ohdo Syndrome, Say-Barber-Biesecker Variant
Synonym: Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant
Tree Number: T10.1.36.1
database_cross_reference: DO:DOID:0060290
database_cross_reference: MSH:C536717
database_cross_reference: OMIM:603736
database_cross_reference: OMIM:605880
database_cross_reference: SNOMEDCT_US:699298009

oculodentodigital dysplasia
type: Class
subclass of: syndrome
definition: A syndrome characterized by craniofacial, neurologic, limb and ocular abnormalities.
PMOID: PMO:00025232
Subclass_of: syndrome
Synonym: Curtius' syndrome
Synonym: Curtius' syndrome I
Synonym: Ectodermal dysplasia with ocular malformations syndrome
Synonym: Ectodermal dysplasia-ocular malformation syndrome
Synonym: Ectodermal dysplasia-ocular malformation syndrome (disorder)
Synonym: Meyer-Schwinkerath and Weyers syndrome
Synonym: Meyer-Schwinkerath syndrome
Synonym: OCULODENTODIGITAL DYSPLASIA
Synonym: OCULODENTODIGITAL DYSPLASIA SYNDROME
Synonym: OCULODENTOOSSEOUS DYSPLASIA
Tree Number: T10.1.94
database_cross_reference: CHV:0000049158
database_cross_reference: DO:DOID:0060291
database_cross_reference: DXP:U001313
database_cross_reference: JABL:494
database_cross_reference: MDR:10063691
database_cross_reference: MSH:C563160
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:121014
database_cross_reference: OMIM:164200
database_cross_reference: RCD:X50Hi
database_cross_reference: SNM:D-5136
database_cross_reference: SNM:D-X423
database_cross_reference: SNMI:D4-00808
database_cross_reference: SNMI:D4-01108
database_cross_reference: SNOMEDCT_US:31291009
database_cross_reference: SNOMEDCT_US:38215007

X-linked chondrodysplasia punctata
type: Class
subclass of: chondrodysplasia punctata
PMOID: PMO:00028836
Subclass_of: chondrodysplasia punctata
Synonym: BCDP
Synonym: BRACHYTELEPHALANGIC CHONDRODYSPLASIA PUNCTATA
Synonym: Brachytelephalangic Chondrodysplasia Punctata
Synonym: CDPX1
Synonym: CHONDRODYSPLASIA PUNCTATA 1, X-LINKED RECESSIVE
Synonym: CHONDRODYSPLASIA PUNCTATA, BRACHYTELEPHALANGIC
Synonym: CHONDRODYSPLASIA PUNCTATA, BRACHYTELEPHALANGIC, AUTOSOMAL
Synonym: CPXR
Synonym: Chondrodysplasia Punctata, Brachytelephalangic, Autosomal
Synonym: Chondrodysplasia punctata 1, X-linked recessive
Tree Number: T10.5.10.3
database_cross_reference: DO:DOID:0060292
database_cross_reference: MSH:C535941
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300180
database_cross_reference: OMIM:302950
database_cross_reference: OMIM:602497

autosomal dominant chondrodysplasia punctata
type: Class
subclass of: chondrodysplasia punctata
PMOID: PMO:00028835
Subclass_of: chondrodysplasia punctata
Synonym: CHONDRODYSPLASIA PUNCTATA DUE TO VITAMIN K DEFICIENCY
Synonym: Chondrodysplasia Punctata Due To Vitamin K Deficiency
Tree Number: T10.5.10.2
database_cross_reference: DO:DOID:0060293
database_cross_reference: MSH:C563248
database_cross_reference: OMIM:118650

uvulitis
type: Class
subclass of: upper respiratory tract disease
PMOID: PMO:00032487
Subclass_of: upper respiratory tract disease
Synonym: Uvulitis
Synonym: Uvulitis (disorder)
Tree Number: T10.8.5.2.4
database_cross_reference: CHV:0000012842
database_cross_reference: MDR:10051962
database_cross_reference: NCI:C128385
database_cross_reference: NCI_NICHD:C128385
database_cross_reference: RCD:Xa7lm
database_cross_reference: SNOMEDCT_US:196544003
database_cross_reference: SNOMEDCT_US:300932000

adenoid hypertrophy
type: Class
subclass of: upper respiratory tract disease
definition: An upper respiratory tract disease characterized by the unusual growth of the adenoid tonsil; has symptom snoring, has symptom hyponasality, has symptom otitis media with effusion, has symptom mouth breathing.
PMOID: PMO:00032488
Subclass_of: upper respiratory tract disease
Synonym: ADENOID HYPERTROPHY
Synonym: ADENOIDS, HYPERTROPHY
Synonym: Adenoid Hypertrophy
Synonym: Adenoid hypertrophy
Synonym: Adenoidal enlargement
Synonym: Adenoidal hypertrophy
Synonym: Enlargement of adenoids
Synonym: Hypertrophy adenoids
Synonym: Hypertrophy of adenoids
Synonym: Hypertrophy of adenoids (disorder)
Tree Number: T10.8.5.2.5
database_cross_reference: CCPSS:0034011
database_cross_reference: CHV:0000016708
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:0060311
database_cross_reference: DXP:U000039
database_cross_reference: HPO:HP:0040261
database_cross_reference: ICD10:J35.2
database_cross_reference: ICD10AM:J35.2
database_cross_reference: ICD10CM:J35.2
database_cross_reference: ICD9CM:474.12
database_cross_reference: ICPC2P:R90001
database_cross_reference: MDR:10001229
database_cross_reference: MDR:10020884
database_cross_reference: MEDCIN:62584
database_cross_reference: MEDCIN:95283
database_cross_reference: RCD:H1412
database_cross_reference: SNMI:DC-71710
database_cross_reference: SNOMEDCT_US:111591002
database_cross_reference: SNOMEDCT_US:195795005

oral hairy leukoplakia
type: Class
subclass of: mouth disease
definition: A mouth disease characterized by a white patch on the side of the tongue with a corrugated or hairy appearance; caused by Epstein-Barr virus.
PMOID: PMO:00033643
Subclass_of: mouth disease
Synonym: Hairy Leukoplakia
Synonym: Hairy Leukoplakia of Mouth
Synonym: Hairy Leukoplakia of Oral Mucosa
Synonym: Hairy Leukoplakia of the Mouth
Synonym: Hairy Leukoplakia of the Oral Mucosa
Synonym: Hairy Leukoplakia, Oral
Synonym: Hairy Leukoplakias
Synonym: Hairy Leukoplakias, Oral
Synonym: Hairy leucoplakia
Synonym: Hairy leukoplakia
Tree Number: T10.8.11.11.4
database_cross_reference: BI:BI00588
database_cross_reference: CCPSS:0016084
database_cross_reference: CHV:0000020850
database_cross_reference: DO:DOID:0060315
database_cross_reference: DXP:U002929
database_cross_reference: HPO:HP:0025126
database_cross_reference: ICD10:K13.3
database_cross_reference: ICD10AM:K13.3
database_cross_reference: ICD10CM:K13.3
database_cross_reference: MDR:10024397
database_cross_reference: MDR:10030979
database_cross_reference: MDR:10052574
database_cross_reference: MEDCIN:335715
database_cross_reference: MSH:D017733
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3722
database_cross_reference: NDFRT:N0000003634
database_cross_reference: RCD:X20Qg
database_cross_reference: SNOMEDCT_US:196569003
database_cross_reference: SNOMEDCT_US:414952002
database_cross_reference: SNOMEDCT_US:58918007

orofaciodigital syndrome I
type: Class
subclass of: orofaciodigital syndrome
definition: An orofaciodigital syndrome that is characterized by malformations of the face, oral cavity, and digits, has_material_basis_in X-linked dominant inheritance of the OFD1 gene with lethality in males and is associated with polycystic kidney disease.
PMOID: PMO:00028746
Subclass_of: orofaciodigital syndrome
Synonym: MOHR SYNDROME
Synonym: Mohr Syndrome
Synonym: Mohr syndrome
Synonym: Mohr syndrome (disorder)
Synonym: Mohr's syndrome
Synonym: Mohr-Claussen syndrome
Synonym: OFD II - Orofacial-digit synd
Synonym: OFD II - Orofacial-digital syndrome II
Synonym: OFD syndrome type II
Synonym: OFD2
Tree Number: T10.5.5.6
database_cross_reference: CHV:0000008205
database_cross_reference: DO:DOID:0060316
database_cross_reference: JABL:503
database_cross_reference: MDR:10078419
database_cross_reference: MDR:10078421
database_cross_reference: MSH:D009958
database_cross_reference: OMIM:252100
database_cross_reference: RCD:PKy51
database_cross_reference: SNM:D-5134
database_cross_reference: SNMI:D4-00804
database_cross_reference: SNOMEDCT_US:1779005

inguinal hernia
type: Class
subclass of: intestinal disease
definition: An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.
PMOID: PMO:00033630
Subclass_of: intestinal disease
Synonym: HERNIA, INGUINAL
Synonym: Hernia - inguinal
Synonym: Hernia inguinal
Synonym: Hernia, Inguinal
Synonym: Hernia, Inguinal [Disease/Finding]
Synonym: Hernia, inguinal
Synonym: Hernia;inguinal
Synonym: Hernias, Inguinal
Synonym: IH - Inguinal hernia
Synonym: INGUINAL HERNIA
Tree Number: T10.8.11.8.31
database_cross_reference: AOD:0000005704
database_cross_reference: BI:BI00268
database_cross_reference: CCPSS:0039579
database_cross_reference: CHV:0000006085
database_cross_reference: COSTAR:418
database_cross_reference: CSP:0944-5779
database_cross_reference: CSP:1250-3532
database_cross_reference: DO:DOID:0060320
database_cross_reference: DXP:U000935
database_cross_reference: DXP:U001965
database_cross_reference: HPO:HP:0000023
database_cross_reference: ICD10:K40
database_cross_reference: ICD10AM:K40
database_cross_reference: ICD10CM:K40
database_cross_reference: ICD10CM:K40.90
database_cross_reference: ICD9CM:550
database_cross_reference: ICPC2EENG:D89
database_cross_reference: ICPC2P:D89001
database_cross_reference: LCH:U002435
database_cross_reference: LCH_NW:sh85066363
database_cross_reference: LNC:LA25050-8
database_cross_reference: MDR:10019917
database_cross_reference: MDR:10022016
database_cross_reference: MDR:10022017
database_cross_reference: MDR:10022019
database_cross_reference: MEDCIN:10297
database_cross_reference: MEDCIN:30148
database_cross_reference: MEDLINEPLUS:283
database_cross_reference: MSH:D006552
database_cross_reference: MTHICD9:550.9
database_cross_reference: NCI:C34690
database_cross_reference: NCI_NICHD:C34690
database_cross_reference: NDFRT:N0000001521
database_cross_reference: OMIM:MTHU036366
database_cross_reference: OMIM:MTHU036928
database_cross_reference: OMIM:MTHU038462
database_cross_reference: RCD:J30y.
database_cross_reference: RCD:J30yz
database_cross_reference: RCD:J30z.
database_cross_reference: RCD:XE0aW
database_cross_reference: SNM:M-31600
database_cross_reference: SNMI:D5-60100
database_cross_reference: SNOMEDCT_US:155738001
database_cross_reference: SNOMEDCT_US:155744002
database_cross_reference: SNOMEDCT_US:196800008
database_cross_reference: SNOMEDCT_US:196822001
database_cross_reference: SNOMEDCT_US:196827007
database_cross_reference: SNOMEDCT_US:196828002
database_cross_reference: SNOMEDCT_US:266440002
database_cross_reference: SNOMEDCT_US:266508004
database_cross_reference: SNOMEDCT_US:266510002
database_cross_reference: SNOMEDCT_US:396232000
database_cross_reference: SNOMEDCT_US:44297005

umbilical hernia
type: Class
subclass of: intestinal disease
definition: A physical disorder characterized by a defect in the development of the abdominal wall muscles, resulting in the intestines, liver and other organs to remain outside of the abdomen in a sac.
PMOID: PMO:00033627
Subclass_of: intestinal disease
Synonym: Amniocele
Synonym: Congenital Omphalocele
Synonym: Congenital omphalocele
Synonym: Congenital omphalocele (disorder)
Synonym: Eventration
Synonym: Exomphalos
Synonym: OMPHALOCELE
Synonym: Omphalecele
Synonym: Omphalocele
Synonym: Omphaloceles
Tree Number: T10.8.11.8.28
database_cross_reference: AOD:0000004990
database_cross_reference: CHV:0000048906
database_cross_reference: DO:DOID:0060321
database_cross_reference: DO:DOID:0060327
database_cross_reference: HPO:HP:0001539
database_cross_reference: ICD10CM:Q79.2
database_cross_reference: ICD9CM:756.72
database_cross_reference: LNC:LA19591-9
database_cross_reference: MDR:10030308
database_cross_reference: MDR:10030309
database_cross_reference: MEDCIN:11573
database_cross_reference: MEDCIN:91381
database_cross_reference: MSH:D006554
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98997
database_cross_reference: NCI_CDISC:C98997
database_cross_reference: NCI_NICHD:C98997
database_cross_reference: OMIM:MTHU005345
database_cross_reference: RCD:J32y0
database_cross_reference: RCD:XE2eb
database_cross_reference: SNM:M-21600
database_cross_reference: SNMI:D4-56130
database_cross_reference: SNOMEDCT_US:18735004
database_cross_reference: SNOMEDCT_US:196854005
database_cross_reference: SNOMEDCT_US:196872004
database_cross_reference: SNOMEDCT_US:271017007
database_cross_reference: SNOMEDCT_US:49324006

breast abscess
type: Class
subclass of: breast disease
definition: A breast disease characterized by a collection of pus in the breast.
PMOID: PMO:00033248
Subclass_of: breast disease
Synonym: ABSCESS BREAST
Synonym: Abscess breast
Synonym: Abscess of breast
Synonym: Abscess of breast (disorder)
Synonym: Abscess of breast, NOS
Synonym: BREAST ABSCESS
Synonym: BREAST, ABSCESS
Synonym: Breast abscess
Synonym: Breast abscess (disorder)
Synonym: MAMMARY ABSCESS
Tree Number: T10.8.9.1.1
database_cross_reference: CCPSS:1015796
database_cross_reference: CHV:0000016972
database_cross_reference: COSTAR:U000088
database_cross_reference: CST:ABSCESS BREAST
database_cross_reference: DO:DOID:0060323
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000242
database_cross_reference: DXP:U000439
database_cross_reference: MDR:10000275
database_cross_reference: MDR:10006171
database_cross_reference: MTHICD9:611.0
database_cross_reference: RCD:X40FP
database_cross_reference: SNMI:D7-90150
database_cross_reference: SNOMEDCT_US:198121003
database_cross_reference: SNOMEDCT_US:28432003

myelomeningocele
type: Class
subclass of: spina bifida
definition: A spina bifida characterized by protrusion of the spinal cord through an opening, covered by meningeal membranes.
PMOID: PMO:00028273
Subclass_of: spina bifida
Synonym: MENINGOMYELOCELE
Synonym: Meningomyelocele
Synonym: Meningomyelocele (disorder)
Synonym: Meningomyelocele NOS
Synonym: Meningomyelocele NOS (disorder)
Synonym: Meningomyelocele [Disease/Finding]
Synonym: Meningomyelocele of unspecified site
Synonym: Meningomyelocele of unspecified site (disorder)
Synonym: Meningomyelocele-unspecif.site
Synonym: Meningomyeloceles
Tree Number: T10.4.16.2.1
database_cross_reference: CCPSS:0046612
database_cross_reference: CHV:0000007944
database_cross_reference: CSP:0724-5863
database_cross_reference: CST:MENINGOMYELOCELE
database_cross_reference: DO:DOID:0060326
database_cross_reference: DXP:U002546
database_cross_reference: HPO:HP:0002475
database_cross_reference: HPO:HP:0030709
database_cross_reference: ICD10CM:Q05
database_cross_reference: LCH:U005762
database_cross_reference: LCH_NW:sh85089224
database_cross_reference: MDR:10027287
database_cross_reference: MDR:10067085
database_cross_reference: MEDCIN:32263
database_cross_reference: MEDCIN:359645
database_cross_reference: MEDLINEPLUS:1319
database_cross_reference: MSH:D008591
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:741.9
database_cross_reference: NCI:C101201
database_cross_reference: NCI_NICHD:C101201
database_cross_reference: NDFRT:N0000001991
database_cross_reference: OMIM:MTHU037353
database_cross_reference: OMIM:MTHU037500
database_cross_reference: PSY:30665
database_cross_reference: PSY:32795
database_cross_reference: RCD:P114.
database_cross_reference: RCD:P1140
database_cross_reference: RCD:P114z
database_cross_reference: RCD:P116.
database_cross_reference: RCD:P1160
database_cross_reference: RCD:P116z
database_cross_reference: SNM:M-21630
database_cross_reference: SNMI:D4-95170
database_cross_reference: SNOMEDCT_US:203984008
database_cross_reference: SNOMEDCT_US:203988006
database_cross_reference: SNOMEDCT_US:203994003
database_cross_reference: SNOMEDCT_US:203995002
database_cross_reference: SNOMEDCT_US:203999008
database_cross_reference: SNOMEDCT_US:414667000
database_cross_reference: SNOMEDCT_US:7096005

omphalocele
type: Class
subclass of: physical disorder
definition: A physical disorder characterized by a defect in the development of the abdominal wall muscles, resulting in the intestines, liver and other organs to remain outside of the abdomen in a sac.
PMOID: PMO:00028269
Subclass_of: physical disorder
Synonym: Amniocele
Synonym: Congenital Omphalocele
Synonym: Congenital omphalocele
Synonym: Congenital omphalocele (disorder)
Synonym: Eventration
Synonym: Exomphalos
Synonym: OMPHALOCELE
Synonym: Omphalecele
Synonym: Omphalocele
Synonym: Omphaloceles
Tree Number: T10.4.15
database_cross_reference: AOD:0000004990
database_cross_reference: CHV:0000048906
database_cross_reference: DO:DOID:0060321
database_cross_reference: DO:DOID:0060327
database_cross_reference: HPO:HP:0001539
database_cross_reference: ICD10CM:Q79.2
database_cross_reference: ICD9CM:756.72
database_cross_reference: LNC:LA19591-9
database_cross_reference: MDR:10030308
database_cross_reference: MDR:10030309
database_cross_reference: MEDCIN:11573
database_cross_reference: MEDCIN:91381
database_cross_reference: MSH:D006554
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98997
database_cross_reference: NCI_CDISC:C98997
database_cross_reference: NCI_NICHD:C98997
database_cross_reference: OMIM:MTHU005345
database_cross_reference: RCD:J32y0
database_cross_reference: RCD:XE2eb
database_cross_reference: SNM:M-21600
database_cross_reference: SNMI:D4-56130
database_cross_reference: SNOMEDCT_US:18735004
database_cross_reference: SNOMEDCT_US:196854005
database_cross_reference: SNOMEDCT_US:196872004
database_cross_reference: SNOMEDCT_US:271017007
database_cross_reference: SNOMEDCT_US:49324006

ectopic pregnancy
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease characterized by the implantation of the embryo outside the uterine cavity.
PMOID: PMO:00029815
Subclass_of: female reproductive system disease
Synonym: 8-02 ECTOPIC PREGNANCIES
Synonym: ECTOPIC PREGN
Synonym: ECTOPIC PREGNANCIES
Synonym: ECTOPIC PREGNANCY
Synonym: EP - Ectopic pregnancy
Synonym: Eccyesis
Synonym: Ectopic Pregnancies
Synonym: Ectopic Pregnancy
Synonym: Ectopic pregnancy
Synonym: Ectopic pregnancy (disorder)
Tree Number: T10.8.1.4.8
database_cross_reference: CCPSS:0058085
database_cross_reference: CCPSS:1017912
database_cross_reference: CHV:0000010065
database_cross_reference: COSTAR:U000217
database_cross_reference: CSP:2403-8709
database_cross_reference: CST:PREGN DIS
database_cross_reference: DO:DOID:0060329
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001067
database_cross_reference: HPO:HP:0031456
database_cross_reference: ICD10:O00
database_cross_reference: ICD10:O00.9
database_cross_reference: ICD10AM:O00
database_cross_reference: ICD10AM:O00.9
database_cross_reference: ICD10CM:O00
database_cross_reference: ICD10CM:O00.9
database_cross_reference: ICD10CM:O00.90
database_cross_reference: ICD9CM:633
database_cross_reference: ICD9CM:633.9
database_cross_reference: ICPC2EENG:W80
database_cross_reference: ICPC2P:W80001
database_cross_reference: LCH:U003806
database_cross_reference: LCH_NW:sh85106288
database_cross_reference: LNC:MTHU015326
database_cross_reference: MDR:10014166
database_cross_reference: MDR:10014169
database_cross_reference: MDR:10015765
database_cross_reference: MDR:10015865
database_cross_reference: MDR:10036559
database_cross_reference: MDR:10045857
database_cross_reference: MDR:10072039
database_cross_reference: MEDCIN:30600
database_cross_reference: MEDLINEPLUS:5811
database_cross_reference: MSH:D011271
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34945
database_cross_reference: NCI_FDA:1819
database_cross_reference: NCI_GAIA:C34945
database_cross_reference: NCI_NCI-GLOSS:CDR0000666673
database_cross_reference: NCI_NCI-GLOSS:CDR0000666674
database_cross_reference: NCI_NICHD:C34945
database_cross_reference: NDFRT:N0000002486
database_cross_reference: RCD:L03..
database_cross_reference: RCD:L03z.
database_cross_reference: SNM:F-31100
database_cross_reference: SNMI:D8-02000
database_cross_reference: SNOMEDCT_US:156080003
database_cross_reference: SNOMEDCT_US:156083001
database_cross_reference: SNOMEDCT_US:198630007
database_cross_reference: SNOMEDCT_US:34801009

chronic atrial and intestinal dysrhythmia
type: Class
subclass of: syndrome
definition: A syndrome characterized by a unique combination of cardiac arrhythmias and intestinal pseudo-obstruction. It has material basis in the mutated SGOL1 protein. Distinctive clinical features include atrial dysrhythmias, sick sinus syndrome (SSS) and valve anomalies and chronic intestinal pseudo-obstruction (CIPO).
PMOID: PMO:00025133
Subclass_of: syndrome
Synonym: CAID
Synonym: CAID (chronic atrial and intestinal dysrhythmia) syndrome
Synonym: CAID syndrome
Synonym: CHRONIC ATRIAL AND INTESTINAL DYSRHYTHMIA
Synonym: Chronic atrial and intestinal dysrhythmia
Synonym: Chronic atrial and intestinal dysrhythmia (disorder)
Tree Number: T10.1.18
database_cross_reference: DO:DOID:0060339
database_cross_reference: OMIM:609168
database_cross_reference: OMIM:616201
database_cross_reference: SNOMEDCT_US:720507006

ciliopathy
type: Class
subclass of: genetic disease
definition: A genetic disease associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia.
PMOID: PMO:00028291
Subclass_of: genetic disease
Synonym: Ciliopathies
Synonym: Ciliopathies [Disease/Finding]
Synonym: Ciliopathy
Tree Number: T10.5.1
database_cross_reference: DO:DOID:0060340
database_cross_reference: MSH:D000072661
database_cross_reference: NDFRT:N0000192939

agnathia-otocephaly complex
type: Class
subclass of: physical disorder
definition: A physical disorder characterized by mandibular hypoplasia or agnathia, ventromedial auricular malposition (melotia) and/or auricular fusion (synotia), and microstomia with oroglossal hypoplasia or aglossia. Holoprosencephaly is the most commonly identified association, but skeletal, genitourinary and cardiovascular anomalies and situs inversus have been reported.
PMOID: PMO:00028260
Subclass_of: physical disorder
Synonym: AGNATHIA-OTOCEPHALY COMPLEX
Synonym: AGOTC
Synonym: Agnathia-otocephaly complex
Synonym: OTOCEPHALY
Synonym: Otocephalic syndrome
Synonym: Otocephalic syndrome (disorder)
Synonym: Otocephalus
Synonym: Otocephaly
Synonym: agnathia-holoprosencephaly-situs inversus syndrome
Synonym: dysgnathia complex agnathia-holoprosencephaly
Tree Number: T10.4.6
database_cross_reference: CCPSS:0045090
database_cross_reference: DO:DOID:0060341
database_cross_reference: ICD10CM:Q18.2
database_cross_reference: MDR:10058118
database_cross_reference: MSH:C562503
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124568
database_cross_reference: NCI_CDISC:C124568
database_cross_reference: OMIM:167420
database_cross_reference: OMIM:202650
database_cross_reference: OMIM:MTHU037231
database_cross_reference: SNMI:D4-00725
database_cross_reference: SNOMEDCT_US:48180002

acrorenal syndrome
type: Class
subclass of: syndrome
PMOID: PMO:00025138
Subclass_of: syndrome
Synonym: ACRORENAL SYNDROME, AUTOSOMAL RECESSIVE
Synonym: Acrorenal Syndrome, Autosomal Recessive
Synonym: Acrorenal syndrome autosomal recessive
Synonym: Acrorenal syndrome recessive
Synonym: Curran syndrome
Tree Number: T10.1.23
database_cross_reference: JABL:9
database_cross_reference: MSH:C535666
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:201310

microcephaly with or without chorioretinopathy, lymphedema, or mental retardation
type: Class
subclass of: syndrome
definition: A syndrome characterized byvariable expression of microcephaly, ocular disorders including chorioretinopathy, congenital lymphedema of the lower limbs, and mild to moderate intellectual disability.
PMOID: PMO:00025167
Subclass_of: syndrome
Synonym: CDMMR SYNDROME
Synonym: Chorioretinal dysplasia-microcephaly-mental retardation syndrome
Synonym: LYMPHEDEMA AND RETINAL FOLDS WITH MICROCEPHALY AND MICROPHTHALMOS
Synonym: LYMPHEDEMA, MICROCEPHALY, CHORIORETINOPATHY SYNDROME
Synonym: Lymphedema and Retinal Folds with Microcephaly and Microphthalmos
Synonym: Lymphedema, Microcephaly, Chorioretinopathy Syndrome
Synonym: Lymphedema, microcephaly and chorioretinopathy syndrome
Synonym: MCLMR
Synonym: MICROCEPHALY AND CHORIORETINOPATHY WITH OR WITHOUT MENTAL RETARDATION, AUTOSOMAL DOMINANT
Synonym: MICROCEPHALY WITH OR WITHOUT CHORIORETINOPATHY, LYMPHEDEMA, OR MENTAL RETARDATION
Tree Number: T10.1.48
database_cross_reference: DO:DOID:0060349
database_cross_reference: MSH:C537711
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:148760
database_cross_reference: OMIM:152950

adenine phosphoribosyltransferase deficiency
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder characterized by the formation 2,8-dihydroxyadenine stones and renal failure secondary to intratubular crystalline precipitation. It has an autosomal recessive inheritance pattern.
PMOID: PMO:00029190
Subclass_of: amino acid metabolic disorder
Synonym: 2,8-dihydroxyadenine urolithiasis
Synonym: ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY
Synonym: APRT DEFICIENCY
Synonym: APRT Deficiency
Synonym: APRT deficiency
Synonym: APRTD
Synonym: Aden phosphoribosyl trans def
Synonym: Adenine Phosphoribosyltransferase Deficiency
Synonym: Adenine phosphoribosyl transferase deficiency
Synonym: Adenine phosphoribosyltransferase deficiency
Tree Number: T10.6.2.15.12
database_cross_reference: DO:DOID:0060350
database_cross_reference: MDR:10072609
database_cross_reference: MSH:C538228
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C121564
database_cross_reference: OMIM:102600
database_cross_reference: OMIM:614723
database_cross_reference: RCD:X40Ug
database_cross_reference: SNMI:D6-40600
database_cross_reference: SNOMEDCT_US:11852004
database_cross_reference: SNOMEDCT_US:124274002

Kleefstra syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by childhood hypotonia, a distinctive facial appearance, speech impediments and developmental disability, as well as epilepsy, congenital and urogenetic defects, microcephaly, corpulence, and psychiatric disorders. It is caused either by a microdeletion in the chromosome region 9q34.3 or by a point mutation in the EHMT1 gene located in that region.
PMOID: PMO:00025147
Subclass_of: syndrome
Synonym: 9q SUBTELOMERIC DELETION SYNDROME
Synonym: 9q Subtelomeric Deletion Syndrome
Synonym: 9q deletion syndrome
Synonym: 9q subtelomeric deletion syndrome
Synonym: 9q- SYNDROME
Synonym: 9q- Syndrome
Synonym: 9q- syndrome
Synonym: 9q-syndrome
Synonym: 9q34 deletion syndrome
Synonym: 9q34.3 Deletion Syndrome
Tree Number: T10.1.29
database_cross_reference: DO:DOID:0060352
database_cross_reference: DO:DOID:0070075
database_cross_reference: JABL:151
database_cross_reference: MSH:C563043
database_cross_reference: OMIM:607001
database_cross_reference: OMIM:610253

chylomicron retention disease
type: Class
subclass of: lipid metabolism disorder
definition: A lipid metabolism disorder characterized by malnutrition, failure to thrive, growth failure, vitamin E deficiency and the absence of chylomicrons and apolipoprotein B48 post-prandially. It has an autosomal recessive inheritance pattern and has material basis in mutations in the SAR1B gene on chromosome 5q31.1.
PMOID: PMO:00029259
Subclass_of: lipid metabolism disorder
Synonym: ANDD
Synonym: ANDERSON DISEASE
Synonym: Anderson Disease
Synonym: Anderson Syndrome
Synonym: Anderson disease
Synonym: Anderson syndrome
Synonym: Anderson's disease
Synonym: Anderson's disease (diagnosis)
Synonym: CHYLOMICRON RETENTION DISEASE
Synonym: CMRD
Tree Number: T10.6.2.18.6
database_cross_reference: CHV:0000048949
database_cross_reference: DO:DOID:0060357
database_cross_reference: ICD10CM:E78.3
database_cross_reference: JABL:31
database_cross_reference: MEDCIN:273573
database_cross_reference: MSH:C535460
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:272.7
database_cross_reference: OMIM:246700
database_cross_reference: OMIM:607690
database_cross_reference: SNOMEDCT_US:190792005
database_cross_reference: SNOMEDCT_US:702364003

multiple acyl-CoA dehydrogenase deficiency
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder characterized by the body's inability to break down proteins and fats to produce energy. It is a disorder of fatty acid, amino acid, and choline metabolism and has an autosomal recessive inheritance pattern. It has material basis in mutations in the ETFA, ETFB and ETFDH genes. It presents three clinical phenotypes: a neonatal-onset form with congenital anomalies (type I), a neonatal-onset form without congenital anomalies (type II), and a late-onset form (type III). The neonatal-onset forms are usually fatal.
PMOID: PMO:00029116
Subclass_of: inherited metabolic disorder
Synonym: ACAD
Synonym: Aciduria, Ethylmalonic-Adipic
Synonym: Acidurias, Ethylmalonic-Adipic
Synonym: EMA
Synonym: ETHYLMALONIC-ADIPICACIDURIA
Synonym: Electron Transfer Flavoprotein Deficiency
Synonym: Ethylmalonic Adipic Aciduria
Synonym: Ethylmalonic Adipicaciduria
Synonym: Ethylmalonic-Adipic Aciduria
Synonym: Ethylmalonic-Adipic Acidurias
Tree Number: T10.6.2.9
database_cross_reference: CHV:0000026335
database_cross_reference: DO:DOID:0060358
database_cross_reference: ICD10CM:E71.313
database_cross_reference: LNC:LA12491-9
database_cross_reference: LNC:LP56759-1
database_cross_reference: MEDCIN:312722
database_cross_reference: MSH:D054069
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84907
database_cross_reference: NCI:C99102
database_cross_reference: NCI_NICHD:C99102
database_cross_reference: NDFRT:N0000181105
database_cross_reference: OMIM:231680
database_cross_reference: RCD:X40UL
database_cross_reference: SNMI:D6-B2120
database_cross_reference: SNOMEDCT_US:22886006

glycerol kinase deficiency
type: Class
subclass of: inherited metabolic disorder
PMOID: PMO:00029032
Subclass_of: inherited metabolic disorder
Synonym: Deficiency of glycerol kinase
Synonym: Deficiency of glycerol kinase (disorder)
Synonym: Familial hyperglycerolaemia
Synonym: Familial hyperglycerolemia
Synonym: GK DEFICIENCY
Synonym: GK1 DEFICIENCY
Synonym: GK1 deficiency
Synonym: GKD
Synonym: GKD - Glycerol kinase defic
Synonym: GKD - Glycerol kinase deficiency
Tree Number: T10.6.2.5
database_cross_reference: CHV:0000026304
database_cross_reference: HPO:HP:0040302
database_cross_reference: JABL:350
database_cross_reference: MSH:C538138
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124845
database_cross_reference: OMIM:300474
database_cross_reference: OMIM:307030
database_cross_reference: RCD:X40Tp
database_cross_reference: SNMI:D6-95360
database_cross_reference: SNOMEDCT_US:124322002
database_cross_reference: SNOMEDCT_US:53986004

mandibulofacial dysostosis with alopecia
type: Class
subclass of: syndrome
definition: A syndrome characterized by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids, and with alopecia.
PMOID: PMO:00025160
Subclass_of: syndrome
Synonym: MANDIBULOFACIAL DYSOSTOSIS WITH ALOPECIA
Synonym: MFDA
Tree Number: T10.1.41
database_cross_reference: DO:DOID:0060365
database_cross_reference: OMIM:131243
database_cross_reference: OMIM:616367

Hennekam syndrome
type: Class
subclass of: lymphatic system disease
definition: A lymphatic system disease characterized by he presence of intestinal lymphangiectasia, mental retardation, and characteristic facial anomalies. It is inherited in an autosomal recessive pattern. Most individuals with Hennekam syndrome have characteristic facial abnormalities, such as a flat face with accompanying puffy eyelids and hypertelorism; the nasal bridge is typically flat and the ears are typically small. Congenital extremity and genital lymphedema is present in most patients.
PMOID: PMO:00032939
Subclass_of: lymphatic system disease
Synonym: HENNEKAM LYMPHANGIECTASIA-LYMPHEDEMA SYNDROME
Synonym: Hennekam Lymphangiectasia-Lymphedema Syndrome
Synonym: Hennekam lymphag-lymphed synd
Synonym: Hennekam lymphangiectasia lymphedema syndrome
Synonym: Hennekam lymphangiectasia-lymphedema syndrome
Synonym: Hennekam lymphangiectasia-lymphedema syndrome (disorder)
Synonym: Hennekam lymphangiectasia-lymphoedema syndrome
Synonym: LYMPHATIC DYSPLASIA, GENERALIZED
Synonym: Lymphangiectasies and lymphedema Hennekam type
Synonym: Lymphatic Dysplasia, Generalized
Tree Number: T10.8.6.4.6
database_cross_reference: DO:DOID:0060366
database_cross_reference: MSH:C537255
database_cross_reference: OMIM:235510
database_cross_reference: RCD:X207u
database_cross_reference: RCDAE:X207u
database_cross_reference: SNOMEDCT_US:234146006

orofaciodigital syndrome III
type: Class
subclass of: orofaciodigital syndrome
definition: A brachydactyly characterized by a nonarticulating great toe set dorsal and proximal to the typical position.
PMOID: PMO:00028750
Subclass_of: orofaciodigital syndrome
Synonym: BRACHYDACTYLY WITH MAJOR PROXIMAL PHALANGEAL SHORTENING
Synonym: Brachydactyly of the hands and feet with duplication of the first toes
Synonym: Brachydactyly with major proximal phalangeal shortening
Synonym: OFD III - Orofacial-digit syn
Synonym: OFD III - Orofacial-digital syndrome III
Synonym: OFD3
Synonym: OFDS III
Synonym: ORAL-FACIAL-DIGITAL SYNDROME, TYPE III
Synonym: OROFACIODIGITAL SYNDROME III
Synonym: Oral-Facial-Digital Syndrome, Type III
Tree Number: T10.5.5.10
database_cross_reference: DO:DOID:0060373
database_cross_reference: DO:DOID:0110979
database_cross_reference: JABL:504
database_cross_reference: MSH:C557817
database_cross_reference: OMIM:258850
database_cross_reference: OMIM:272150
database_cross_reference: RCD:X50Hg
database_cross_reference: SNOMEDCT_US:239030004

orofaciodigital syndrome IV
type: Class
subclass of: orofaciodigital syndrome
definition: An orofaciodigital syndrome characterized by severe tibial dysplasia and has_material_basis_in homozygous or compound heterozygous mutation in the TCTN3 gene on chromosome 10q24.
PMOID: PMO:00028741
Subclass_of: orofaciodigital syndrome
Synonym: BARAITSER-BURN SYNDROME
Synonym: Baraitser-Burn syndrome
Synonym: MOHR-MAJEWSKI SYNDROME
Synonym: OFD IV - Orofacial-digit synd
Synonym: OFD IV - Orofacial-digital syndrome IV
Synonym: OFD SYNDROME WITH TIBIAL DEFECTS
Synonym: OFD SYNDROME, BARAITSER-BURN TYPE
Synonym: OFD Syndrome With Tibial Defects
Synonym: OFD Syndrome, Baraitser-Burn Type
Synonym: OFD4
Tree Number: T10.5.5.1
database_cross_reference: DO:DOID:0060374
database_cross_reference: JABL:505
database_cross_reference: MSH:C537133
database_cross_reference: OMIM:258860
database_cross_reference: OMIM:613847
database_cross_reference: RCD:X50Hh
database_cross_reference: SNOMEDCT_US:239031000

orofaciodigital syndrome V
type: Class
subclass of: orofaciodigital syndrome
definition: An orofaciodigital syndrome that is characterized by postaxial polydactyly and median cleft of the upper lip and has_material_basis_in homozygous mutation in the DDX59 gene on chromosome 1q32.
PMOID: PMO:00028748
Subclass_of: orofaciodigital syndrome
Synonym: OFD5
Synonym: OFDS V
Synonym: ORAL-FACIAL-DIGITAL SYNDROME, TYPE V
Synonym: OROFACIODIGITAL SYNDROME V
Synonym: OROFACIODIGITAL SYNDROME, THURSTON TYPE
Synonym: Oral-Facial-Digital Syndrome, Type V
Synonym: Oral-facial-digital syndrome 5
Synonym: Oro-facial digital syndrome type 5
Synonym: Oro-facial digital syndrome type 5 (disorder)
Synonym: Orofaciodigital syndrome 5
Tree Number: T10.5.5.8
database_cross_reference: DO:DOID:0060375
database_cross_reference: MSH:C557819
database_cross_reference: OMIM:174300
database_cross_reference: OMIM:615464
database_cross_reference: SNOMEDCT_US:722105002

Joubert syndrome with orofaciodigital defect
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that is characterized by orofaciodigital defect.
PMOID: PMO:00028323
Subclass_of: Joubert syndrome
Synonym: Joubert syndrome with oro-facial-digital syndrome
Synonym: Joubert syndrome with orofaciodigital defect (disorder)
Synonym: Juberg syndrome with polydactyly
Synonym: Juberg-Hayward syndrome
Synonym: OFD6
Synonym: OFDS VI
Synonym: ORAL-FACIAL-DIGITAL SYNDROME, TYPE VI
Synonym: OROFACIODIGITAL SYNDROME VI
Synonym: Oral-Facial-Digital Syndrome, Type VI
Synonym: Oral-facial-digital syndrome, type 6
Tree Number: T10.5.1.1.31
database_cross_reference: DO:DOID:0060376
database_cross_reference: JABL:506
database_cross_reference: MSH:C536531
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124841
database_cross_reference: OMIM:277170
database_cross_reference: OMIM:614571
database_cross_reference: SNOMEDCT_US:721873007

orofaciodigital syndrome VII
type: Class
subclass of: orofaciodigital syndrome
definition: An orofaciodigital syndrome characterized by oral (tongue nodules, bifid tongue, midline cleft of the lip), facial (hypertelorism, alar hypoplasia), and digital abnormalities (clinodactyly).
PMOID: PMO:00028745
Subclass_of: orofaciodigital syndrome
Synonym: OFD7
Synonym: OFDS VII
Synonym: ORAL-FACIAL-DIGITAL SYNDROME, TYPE VII
Synonym: OROFACIODIGITAL SYNDROME VII
Synonym: Oral-Facial-Digital Syndrome, Type VII
Synonym: Orofaciodigital Syndrome VII
Synonym: WHELAN SYNDROME
Synonym: Whelan Syndrome
Synonym: Whelan syndrome
Synonym: digito-orofacial syndrome VII
Tree Number: T10.5.5.5
database_cross_reference: DO:DOID:0060377
database_cross_reference: JABL:507
database_cross_reference: MSH:C563104
database_cross_reference: OMIM:608518

orofaciodigital syndrome VIII
type: Class
subclass of: orofaciodigital syndrome
definition: An orofaciodigital syndrome characterized by hypertelorism or telecanthus, broad, bifid nasal tip, median cleft lip, tongue lobulation and/or hamartomas, oral frenula, high-arched or cleft palate, bilateral polydactyly, and duplicated halluces.
PMOID: PMO:00028751
Subclass_of: orofaciodigital syndrome
Synonym: Edwards syndrome
Synonym: OFD8
Synonym: OFDS VIII
Synonym: ORAL-FACIAL-DIGITAL SYNDROME WITH HYPOPLASTIC EPIGLOTTIS
Synonym: ORAL-FACIAL-DIGITAL SYNDROME, TYPE VIII
Synonym: OROFACIODIGITAL SYNDROME VIII
Synonym: Oral-facial-digital syndrome 8
Synonym: Orofaciodigital syndrome 8
Synonym: Orofaciodigital syndrome VIII
Synonym: digito-orofacial syndrome VIII
Tree Number: T10.5.5.11
database_cross_reference: DO:DOID:0060378
database_cross_reference: JABL:508
database_cross_reference: MSH:C557820
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300484

orofaciodigital syndrome X
type: Class
subclass of: orofaciodigital syndrome
definition: An orofaciodigital syndrome characterized by mesomelic limb shortening.
PMOID: PMO:00028747
Subclass_of: orofaciodigital syndrome
Synonym: Figuera syndrome
Synonym: OFD10
Synonym: OFDS X
Synonym: ORAL-FACIAL-DIGITAL SYNDROME WITH FIBULAR APLASIA
Synonym: ORAL-FACIAL-DIGITAL SYNDROME, TYPE X
Synonym: OROFACIODIGITAL SYNDROME WITH FIBULAR APLASIA
Synonym: OROFACIODIGITAL SYNDROME X
Synonym: Oral-Facial-Digital Syndrome with Fibular Aplasia
Synonym: Oral-Facial-Digital Syndrome, Type X
Synonym: Oro-facial digital syndrome type 10
Tree Number: T10.5.5.7
database_cross_reference: DO:DOID:0060380
database_cross_reference: MSH:C563491
database_cross_reference: OMIM:165590
database_cross_reference: SNOMEDCT_US:722075004

orofaciodigital syndrome XI
type: Class
subclass of: orofaciodigital syndrome
definition: An orofaciodigital syndrome characterized by skeletal anomalies and severe psychomotor delay.
PMOID: PMO:00028744
Subclass_of: orofaciodigital syndrome
Synonym: GABRIELLI SYNDROME
Synonym: Gabrielli syndrome
Synonym: OFD11
Synonym: OFDS XI
Synonym: ORAL-FACIAL-DIGITAL SYNDROME WITH SKELETAL ANOMALIES
Synonym: ORAL-FACIAL-DIGITAL SYNDROME, TYPE XI
Synonym: OROFACIODIGITAL SYNDROME XI
Synonym: Oral-Facial-Digital Syndrome with Skeletal Anomalies
Synonym: Oral-Facial-Digital Syndrome, Type XI
Synonym: Oral-facial-digital syndrome 11
Tree Number: T10.5.5.4
database_cross_reference: DO:DOID:0060381
database_cross_reference: MSH:C557821
database_cross_reference: OMIM:612913

orofaciodigital syndrome IX
type: Class
subclass of: orofaciodigital syndrome
definition: An orofaciodigital syndrome characterized by retinal abnormalities, and a lobulated or hamartomatous tongue.
PMOID: PMO:00028742
Subclass_of: orofaciodigital syndrome
Synonym: OFD9
Synonym: OFDS IX
Synonym: ORAL-FACIAL-DIGITAL SYNDROME WITH RETINAL ABNORMALITIES
Synonym: ORAL-FACIAL-DIGITAL SYNDROME, TYPE IX
Synonym: OROFACIODIGITAL SYNDROME IX
Synonym: OROFACIODIGITAL SYNDROME WITH RETINAL ABNORMALITIES
Synonym: Oral Facial Digital Syndrome, Type IX
Synonym: Oral-facial-digital syndrome 9
Synonym: Oral-facial-digital syndrome type 9
Synonym: Oral-facial-digital syndrome with retinal abnormalities
Tree Number: T10.5.5.2
database_cross_reference: DO:DOID:0060382
database_cross_reference: JABL:509
database_cross_reference: MSH:C557818
database_cross_reference: OMIM:258865
database_cross_reference: SNOMEDCT_US:718680001

chromosomal deletion syndrome
type: Class
subclass of: chromosomal disease
PMOID: PMO:00028777
Subclass_of: chromosomal disease
Tree Number: T10.5.9.8
database_cross_reference: DO:DOID:0060388

chromosome 10q23 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
definition: An autosomal dominant disease that is characterized by predisposition to hamartomatous benign polyps in the gastrointestinal tract, specifically in the stomach, small intestine, colon, and rectum.
PMOID: PMO:00028785
Subclass_of: chromosomal deletion syndrome
Synonym: JIP
Synonym: JPS
Synonym: JUVENILE INTESTINAL POLYPOSIS
Synonym: JUVENILE POLYPOSIS OF INFANCY
Synonym: JUVENILE POLYPOSIS SYNDROME
Synonym: JUVENILE POLYPOSIS, INFANTILE
Synonym: Juvenile Multiple Polyps Syndrome
Synonym: Juvenile Polyposis
Synonym: Juvenile Polyposis Of Infancy
Synonym: Juvenile Polyposis Syndrome
Tree Number: T10.5.9.8.8
database_cross_reference: DO:DOID:0050787
database_cross_reference: DO:DOID:0060389
database_cross_reference: MSH:C537702
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C7754
database_cross_reference: OMIM:174900
database_cross_reference: OMIM:600993
database_cross_reference: OMIM:601299
database_cross_reference: OMIM:612242
database_cross_reference: RCD:X78Oj
database_cross_reference: SNMI:D4-01034
database_cross_reference: SNOMEDCT_US:9273005

distal 10q deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028788
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 10q26 DELETION SYNDROME
Synonym: Chromosome 10q26 Deletion Syndrome
Synonym: TERMINAL CHROMOSOME 10q26 DELETION SYNDROME
Synonym: Terminal Chromosome 10q26 Deletion Syndrome
Synonym: chromosome 10q26 deletion syndrome
Synonym: distal monosomy 10q
Synonym: monosomy 10qter
Synonym: telomeric deletion 10q
Synonym: terminal chromosome 10q26 deletion syndrome
Tree Number: T10.5.9.8.11
database_cross_reference: DO:DOID:0060390
database_cross_reference: MSH:C567182
database_cross_reference: OMIM:609625

chromosome 13q14 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028786
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 13q DELETION SYNDROME
Synonym: CHROMOSOME 13q14 DELETION SYNDROME
Synonym: Chromosome 13q14 deletion syndrome
Synonym: deletion 13q14
Tree Number: T10.5.9.8.9
database_cross_reference: DO:DOID:0060391
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:613884

chromosome 14q11-q22 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028809
Subclass_of: chromosomal deletion syndrome
Synonym: 14q11.2 microdeletion syndrome
Synonym: CHROMOSOME 14q11-q22 DELETION SYNDROME
Tree Number: T10.5.9.8.32
database_cross_reference: DO:DOID:0060392
database_cross_reference: OMIM:613457

chromosome 15q11.2 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028804
Subclass_of: chromosomal deletion syndrome
Synonym: 15q11.2 microdeletion
Synonym: 15q11.2 microdeletion syndrome
Synonym: CHROMOSOME 15q11.2 DELETION SYNDROME
Synonym: Chromosome 15q11.2 deletion syndrome
Synonym: Microdeletion 15q11.2
Tree Number: T10.5.9.8.27
database_cross_reference: DO:DOID:0060393
database_cross_reference: MSH:C557830
database_cross_reference: OMIM:615656

chromosome 15q13.3 microdeletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028783
Subclass_of: chromosomal deletion syndrome
Synonym: 15q13.3 Microdeletion
Synonym: 15q13.3 Microdeletion Syndrome
Synonym: 15q13.3 deletion syndrome
Synonym: 15q13.3 microdeletion
Synonym: 15q13.3 microdeletion syndrome
Synonym: CHROMOSOME 15q13.3 DELETION SYNDROME
Synonym: CHROMOSOME 15q13.3 MICRODELETION SYNDROME
Synonym: Chromosome 15q13.3 Deletion Syndrome
Synonym: Chromosome 15q13.3 Microdeletion Syndrome
Synonym: Microdeletion 15q13.3 Syndrome
Tree Number: T10.5.9.8.6
database_cross_reference: DO:DOID:0060394
database_cross_reference: MSH:C567439
database_cross_reference: OMIM:612001
database_cross_reference: SNOMEDCT_US:699254009

chromosome 15q24 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028813
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 15q24 DELETION SYNDROME
Tree Number: T10.5.9.8.36
database_cross_reference: OMIM:613406

chromosome 15q25 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028778
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 15q25 DELETION SYNDROME
Tree Number: T10.5.9.8.1
database_cross_reference: DO:DOID:0060396
database_cross_reference: OMIM:614294

chromosome 15q26-qter deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028825
Subclass_of: chromosomal deletion syndrome
Synonym: 15q26 deletion syndrome
Synonym: CHROMOSOME 15q26-qter DELETION SYNDROME
Synonym: Chromosome 15q26-Qter Deletion Syndrome
Synonym: DRAYER SYNDROME
Synonym: Drayer Syndrome
Synonym: Drayer syndrome
Synonym: distal 15q deletion syndrome
Synonym: distal monosomy 15q
Synonym: telomeric 15q deletion syndrome
Tree Number: T10.5.9.8.48
database_cross_reference: DO:DOID:0060397
database_cross_reference: MSH:C567232
database_cross_reference: OMIM:612626

chromosome 16p11.2 deletion syndrome, 220kb
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028792
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 16p11.2 DELETION SYNDROME, 220-KB
Synonym: distal 16p11.2 microdeletion syndrome
Tree Number: T10.5.9.8.15
database_cross_reference: DO:DOID:0060398
database_cross_reference: OMIM:613444

chromosome 16p12.1 deletion syndrome, 520kb
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028817
Subclass_of: chromosomal deletion syndrome
Synonym: FRAGILE SITE 16p12
Synonym: Fragile Site 16p12
Tree Number: T10.5.9.8.40
database_cross_reference: DO:DOID:0060399
database_cross_reference: MSH:C565001
database_cross_reference: OMIM:136570

chromosome 16p12.2-p11.2 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028810
Subclass_of: chromosomal deletion syndrome
Synonym: 16p11.2-p12.2 microdeletion syndrome
Synonym: 16p11.2p12.2 microdeletion syndrome
Synonym: CHROMOSOME 16p12.2-p11.2 DELETION SYNDROME, 7.1- TO 8.7-MB
Tree Number: T10.5.9.8.33
database_cross_reference: DO:DOID:0060400
database_cross_reference: OMIM:613604

chromosome 16q22 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028822
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 16q22 DELETION SYNDROME
Tree Number: T10.5.9.8.45
database_cross_reference: DO:DOID:0060401
database_cross_reference: OMIM:614541

chromosome 17p13.1 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028820
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 17p13.1 DELETION SYNDROME
Tree Number: T10.5.9.8.43
database_cross_reference: DO:DOID:0060402
database_cross_reference: OMIM:613776

chromosome 17q11.2 deletion syndrome, 1.4Mb
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028819
Subclass_of: chromosomal deletion syndrome
Synonym: 17q11 microdeletion syndrome
Synonym: CHROMOSOME 17q11.2 DELETION SYNDROME, 1.4-MB
Synonym: NEUROFIBROMATOSIS 1 MICRODELETION SYNDROME
Synonym: NF1 MICRODELETION SYNDROME
Synonym: NF1 Microdeletion Syndrome
Synonym: NF1 microdeletion syndrome
Synonym: VAN ASPEREN SYNDROME
Synonym: Van Asperen syndrome
Synonym: neurofibromatosis type 1 microdeletion syndrome
Tree Number: T10.5.9.8.42
database_cross_reference: DO:DOID:0060403
database_cross_reference: MSH:C563524
database_cross_reference: OMIM:613675

chromosome 17q12 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028780
Subclass_of: chromosomal deletion syndrome
Synonym: 17q12 microdeletion syndrome
Synonym: CHROMOSOME 17q12 DELETION SYNDROME
Tree Number: T10.5.9.8.3
database_cross_reference: DO:DOID:0060404
database_cross_reference: OMIM:614527

chromosome 17q23.1-q23.2 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028791
Subclass_of: chromosomal deletion syndrome
Synonym: 17q23.1-q23.2 microdeletion syndrome
Synonym: 17q23.1q23.2 microdeletion syndrome
Synonym: CHROMOSOME 17q23.1-q23.2 DELETION SYNDROME
Tree Number: T10.5.9.8.14
database_cross_reference: DO:DOID:0060405
database_cross_reference: OMIM:613355

chromosome 18p deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028800
Subclass_of: chromosomal deletion syndrome
Synonym: 18P Syndrome
Synonym: 18p deletion syndrome
Synonym: 18p minus syndrome
Synonym: 18p monosomy
Synonym: 18p syndrome
Synonym: 18p- SYNDROME
Synonym: 18p- syndrome
Synonym: CHROMOSOME 18p DELETION SYNDROME
Synonym: Chromosome 18p deletion syndrome
Synonym: De Grouchy syndrome
Tree Number: T10.5.9.8.23
database_cross_reference: CHV:0000034194
database_cross_reference: DO:DOID:0060406
database_cross_reference: JABL:192
database_cross_reference: MEDCIN:360403
database_cross_reference: MSH:C538309
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84521
database_cross_reference: OMIM:146390
database_cross_reference: RCD:XE2ad
database_cross_reference: SNOMEDCT_US:205631008
database_cross_reference: SNOMEDCT_US:205632001
database_cross_reference: SNOMEDCT_US:270890001

chromosome 18q deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028793
Subclass_of: chromosomal deletion syndrome
Synonym: 18Q Syndrome
Synonym: 18q deletion syndrome
Synonym: 18q syndrome
Synonym: 18q- SYNDROME
Synonym: 18q- Syndrome
Synonym: 18q- syndrome
Synonym: CHROMOSOME 18q DELETION SYNDROME
Synonym: CHROMOSOME 18q- SYNDROME
Synonym: Chromosome 18 deletion syndrome
Synonym: Chromosome 18q Deletion Syndrome
Tree Number: T10.5.9.8.16
database_cross_reference: CHV:0000034195
database_cross_reference: DO:DOID:0060407
database_cross_reference: JABL:194
database_cross_reference: MDR:10066051
database_cross_reference: MEDCIN:360402
database_cross_reference: MSH:C536580
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84522
database_cross_reference: OMIM:601808
database_cross_reference: RCD:XE2ac
database_cross_reference: SNOMEDCT_US:205631008
database_cross_reference: SNOMEDCT_US:205632001
database_cross_reference: SNOMEDCT_US:270889005

chromosome 19q13.11 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028796
Subclass_of: chromosomal deletion syndrome
Synonym: 19q13.11 microdeletion syndrome
Synonym: Chromosome 19q13.11 Deletion Syndrome
Synonym: monosomy 19q13.11
Tree Number: T10.5.9.8.19
database_cross_reference: DO:DOID:0060408
database_cross_reference: MSH:C567810

chromosome 1p32-p31 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028816
Subclass_of: chromosomal deletion syndrome
Synonym: 1p31p32 microdeletion syndrome
Synonym: CHROMOSOME 1p32-p31 DELETION SYNDROME
Tree Number: T10.5.9.8.39
database_cross_reference: DO:DOID:0060409
database_cross_reference: OMIM:613735

chromosome 1p36 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028798
Subclass_of: chromosomal deletion syndrome
Synonym: 1p Telomere Deletion Syndrome
Synonym: 1p36 Deletion Syndrome
Synonym: 1p36 deletion syndrome
Synonym: CHROMOSOME 1p36 DELETION SYNDROME
Synonym: Chromosome 1, 1p36 deletion syndrome
Synonym: Chromosome 1p36 Deletion Syndrome
Synonym: Chromosome 1p36 deletion syndrome
Synonym: Chromosome 1p36 deletion syndrome (disorder)
Synonym: Distal monosomy 1p36
Synonym: MONOSOMY 1p36 SYNDROME
Tree Number: T10.5.9.8.21
database_cross_reference: DO:DOID:0060410
database_cross_reference: MSH:C535362
database_cross_reference: NCI:C74983
database_cross_reference: OMIM:607872
database_cross_reference: SNOMEDCT_US:699306003

chromosome 1q21.1 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028814
Subclass_of: chromosomal deletion syndrome
Synonym: Absent radii and thrombocytopenia
Synonym: CHROMOSOME 1q21.1 DELETION SYNDROME, 200-KB
Synonym: Chromosome 1q21.1 Deletion Syndrome, 200-Kb
Synonym: Radial Aplasia-Amegakaryocytic Thrombocytopenia
Synonym: Radial Aplasia-Thrombocytopenia Syndrome
Synonym: Radial aplasia-thrombocytopenia syndrome
Synonym: Radial aplasia-thrombocytopenia syndrome (disorder)
Synonym: TAR
Synonym: TAR - Thrombocy abse rad synd
Synonym: TAR - Thrombocytopenia with absent radius syndrome
Tree Number: T10.5.9.8.37
database_cross_reference: CCPSS:0059219
database_cross_reference: CHV:0000018180
database_cross_reference: DO:DOID:14699
database_cross_reference: ICD10CM:Q87.2
database_cross_reference: MDR:10071719
database_cross_reference: MDR:10071720
database_cross_reference: MEDCIN:277685
database_cross_reference: MSH:C536940
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:287.33
database_cross_reference: NCI:C99038
database_cross_reference: NCI_NICHD:C99038
database_cross_reference: OMIM:274000
database_cross_reference: OMIM:605313
database_cross_reference: PDQ:CDR0000285979
database_cross_reference: RCD:D3132
database_cross_reference: SNM:D-5176
database_cross_reference: SNM:D-5366
database_cross_reference: SNMI:D4-00908
database_cross_reference: SNOMEDCT_US:85589009

chromosome 1q41-q42 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028806
Subclass_of: chromosomal deletion syndrome
Synonym: 1q41-q42 microdeletion syndrome
Synonym: 1q41q42 microdeletion syndrome
Synonym: CHROMOSOME 1q41-q42 DELETION SYNDROME
Synonym: HOLOPROSENCEPHALY 10
Synonym: HPE10
Synonym: Holoprosencephaly 10
Synonym: Holoprosencephaly with Microphthalmia and First Branchial Arch Anomalies
Tree Number: T10.5.9.8.29
database_cross_reference: DO:DOID:0060412
database_cross_reference: MSH:C567278
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:612530

chromosome 22q11.2 deletion syndrome, distal
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028787
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 22q11.2 DELETION SYNDROME, DISTAL
Synonym: Chromosome 22q11.2 Deletion Syndrome, Distal
Synonym: DISTAL CHROMOSOME 22q11.2 DELETION SYNDROME
Synonym: Distal Chromosome 22q11.2 Deletion Syndrome
Synonym: distal 22q11.2 microdeletion syndrome
Tree Number: T10.5.9.8.10
database_cross_reference: DO:DOID:0060413
database_cross_reference: MSH:C567511
database_cross_reference: OMIM:611867

chromosome 2p12-p11.2 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028811
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 2p12-p11.2 DELETION SYNDROME
Tree Number: T10.5.9.8.34
database_cross_reference: DO:DOID:0060414
database_cross_reference: OMIM:613564

chromosome 2p16.1-p15 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028801
Subclass_of: chromosomal deletion syndrome
Synonym: 2p15p16.1 microdeletion syndrome
Synonym: CHROMOSOME 2p16.1-p15 DELETION SYNDROME
Synonym: Chromosome 2p16.1-P15 Deletion Syndrome
Tree Number: T10.5.9.8.24
database_cross_reference: DO:DOID:0060415
database_cross_reference: MSH:C567289
database_cross_reference: OMIM:612513

chromosome 2q31.2 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028821
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 2q31.2 DELETION SYNDROME
Synonym: Chromosome 2q31.2 Deletion Syndrome
Tree Number: T10.5.9.8.44
database_cross_reference: DO:DOID:0060416
database_cross_reference: MSH:C567344
database_cross_reference: OMIM:612345

3p- syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028779
Subclass_of: chromosomal deletion syndrome
Synonym: 3p deletion syndrome
Synonym: 3p partial monosomy syndrome
Synonym: 3p partial monosomy syndrome (diagnosis)
Synonym: 3p partial monosomy syndrome (disorder)
Synonym: 3p- SYNDROME
Synonym: CHROMOSOME 3pter-p25 DELETION SYNDROME
Synonym: Chromosome 3, deletion 3p
Synonym: Chromosome 3, monosomy 3p
Synonym: Chromosome 3p deletion syndrome
Synonym: Deletion 3p
Tree Number: T10.5.9.8.2
database_cross_reference: CHV:0000048921
database_cross_reference: DO:DOID:0060417
database_cross_reference: JABL:117
database_cross_reference: MEDCIN:361210
database_cross_reference: MSH:C536804
database_cross_reference: OMIM:613792
database_cross_reference: SNOMEDCT_US:449819002

chromosome 3q13.31 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028826
Subclass_of: chromosomal deletion syndrome
Synonym: 3q13 microdeletion syndrome
Synonym: Chromosome 3, monosomy 3q13
Synonym: Deletion 3q13
Synonym: Monosomy 3q13
Synonym: monosomy 3q13
Tree Number: T10.5.9.8.49
database_cross_reference: DO:DOID:0060418
database_cross_reference: MSH:C536808

chromosome 3q29 microdeletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028815
Subclass_of: chromosomal deletion syndrome
Synonym: 3q subtelomere deletion syndrome
Synonym: 3q29 microdeletion syndrome
Synonym: 3q29 microdeletion syndrome (disorder)
Synonym: 3qter deletion
Synonym: CHROMOSOME 3q29 DELETION SYNDROME
Synonym: Chromosome 3q29 Deletion Syndrome
Synonym: MICRODELETION 3q29 SYNDROME
Synonym: Microdeletion 3q29 Syndrome
Synonym: Monosomy 3q29
Tree Number: T10.5.9.8.38
database_cross_reference: DO:DOID:0060419
database_cross_reference: MSH:C567184
database_cross_reference: OMIM:609425
database_cross_reference: SNOMEDCT_US:716456000

chromosome 4q21 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028803
Subclass_of: chromosomal deletion syndrome
Synonym: 4q21 microdeletion syndrome
Synonym: CHROMOSOME 4q21 DELETION SYNDROME
Synonym: monosomy 4q21
Tree Number: T10.5.9.8.26
database_cross_reference: DO:DOID:0060420
database_cross_reference: OMIM:613509

chromosome 5q12 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028781
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 5q12 DELETION SYNDROME
Tree Number: T10.5.9.8.4
database_cross_reference: DO:DOID:0060421
database_cross_reference: OMIM:615668

chromosome 6pter-p24 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028807
Subclass_of: chromosomal deletion syndrome
Synonym: 6p subtelomeric deletion syndrome
Synonym: 6p25 microdeletion syndrome
Synonym: CHROMOSOME 6pter-p24 DELETION SYNDROME
Synonym: Chromosome 6pter-P24 Deletion Syndrome
Synonym: distal monosomy 6p
Tree Number: T10.5.9.8.30
database_cross_reference: DO:DOID:0060422
database_cross_reference: MSH:C567239
database_cross_reference: OMIM:612582

chromosome 6q11-q14 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028802
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 6q11-q14 DELETION SYNDROME
Tree Number: T10.5.9.8.25
database_cross_reference: DO:DOID:0060423
database_cross_reference: OMIM:613544

chromosome 6q24-q25 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028799
Subclass_of: chromosomal deletion syndrome
Synonym: 6q25 microdeletion syndrome
Synonym: CHROMOSOME 6q24-q25 DELETION SYNDROME
Synonym: monosomy 6q25
Tree Number: T10.5.9.8.22
database_cross_reference: DO:DOID:0060424
database_cross_reference: OMIM:612863

chromosome 8q21.11 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028823
Subclass_of: chromosomal deletion syndrome
Synonym: 8q21.11 microdeletion syndrome
Synonym: CHROMOSOME 8q21.11 DELETION SYNDROME
Tree Number: T10.5.9.8.46
database_cross_reference: DO:DOID:0060425
database_cross_reference: OMIM:614230

chromosome 19p13.13 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028818
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME 19p13.13 DELETION SYNDROME
Tree Number: T10.5.9.8.41
database_cross_reference: DO:DOID:0060426
database_cross_reference: OMIM:613638

chromosome Xp21 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028790
Subclass_of: chromosomal deletion syndrome
Synonym: CHROMOSOME Xp21 DELETION SYNDROME
Synonym: COMPLEX GLYCEROL KINASE DEFICIENCY
Synonym: Xp21 microdeletion syndrome
Synonym: Xp21- syndrome
Synonym: chromosome Xp21 monosomy
Synonym: complex glycerol kinase deficiency
Synonym: del(Xp21) syndrome
Synonym: deletion Xp21 syndrome
Synonym: monosomy Xp21
Synonym: partial monosomy Xp21
Tree Number: T10.5.9.8.13
database_cross_reference: DO:DOID:0060427
database_cross_reference: JABL:218
database_cross_reference: OMIM:300679

chromosome 2q32-q33 deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028812
Subclass_of: chromosomal deletion syndrome
Synonym: 2q32-q33 microdeletion syndrome
Synonym: 2q32q33 microdeletion syndrome
Synonym: CHROMOSOME 2q32-q33 DELETION SYNDROME
Synonym: Chromosome 2q32-Q33 Deletion Syndrome
Synonym: GLASS
Synonym: GLASS SYNDROME
Synonym: Glass syndrome
Synonym: monosomy 2q32
Synonym: monosomy 2q32-q33
Synonym: monosomy 2q32q33
Tree Number: T10.5.9.8.35
database_cross_reference: DO:DOID:0060428
database_cross_reference: MSH:C567350
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:608148
database_cross_reference: OMIM:612313

chromosomal duplication syndrome
type: Class
subclass of: chromosomal disease
PMOID: PMO:00028760
Subclass_of: chromosomal disease
Tree Number: T10.5.9.5
database_cross_reference: DO:DOID:0060429

chromosome 16p11.2 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028765
Subclass_of: chromosomal duplication syndrome
Synonym: CHROMOSOME 16p11.2 DUPLICATION SYNDROME
Synonym: proximal 16p11.2 microduplication syndrome
Synonym: proximal dup(16)(p11.2)
Synonym: proximal trisomy 16p11.2
Tree Number: T10.5.9.5.5
database_cross_reference: DO:DOID:0060430
database_cross_reference: OMIM:614671

chromosome 16p13.3 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028774
Subclass_of: chromosomal duplication syndrome
Synonym: 16p13.3 microduplication syndrome
Synonym: CHROMOSOME 16p13.3 DUPLICATION SYNDROME
Synonym: distal duplication 16p
Synonym: distal trisomy 16p
Synonym: telomeric duplication 16p
Tree Number: T10.5.9.5.14
database_cross_reference: DO:DOID:0060431
database_cross_reference: OMIM:613458

chromosome 17p13.3 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028761
Subclass_of: chromosomal duplication syndrome
Synonym: Chromosome 17p13.3 Duplication Syndrome
Tree Number: T10.5.9.5.1
database_cross_reference: MSH:C567705

chromosome 17q12 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028767
Subclass_of: chromosomal duplication syndrome
Synonym: 17q12 microduplication syndrome
Synonym: CHROMOSOME 17q12 DUPLICATION SYNDROME
Synonym: trisomy 17q12
Tree Number: T10.5.9.5.7
database_cross_reference: DO:DOID:0060433
database_cross_reference: OMIM:614526

chromosome 17q21.31 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028762
Subclass_of: chromosomal duplication syndrome
Synonym: 17q21.31 microduplication syndrome
Synonym: CHROMOSOME 17q21.31 DUPLICATION SYNDROME
Synonym: trisomy 17q21.31
Tree Number: T10.5.9.5.2
database_cross_reference: DO:DOID:0060434
database_cross_reference: OMIM:613533

chromosome 1q21.1 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028763
Subclass_of: chromosomal duplication syndrome
Synonym: 1q21.1 microduplication syndrome
Synonym: CHROMOSOME 1q21.1 DUPLICATION SYNDROME
Synonym: Chromosome 1q21.1 Duplication Syndrome
Synonym: trisomy 1q21.1
Tree Number: T10.5.9.5.3
database_cross_reference: DO:DOID:0060435
database_cross_reference: MSH:C567290
database_cross_reference: OMIM:612475

chromosome 22q11.2 microduplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028768
Subclass_of: chromosomal duplication syndrome
Synonym: 22q11.2 Duplication
Synonym: 22q11.2 duplication
Synonym: 22q11.2 duplication (disorder)
Synonym: 22q11.2 microduplication syndrome
Synonym: CHROMOSOME 22q11.2 DUPLICATION SYNDROME
Synonym: CHROMOSOME 22q11.2 MICRODUPLICATION SYNDROME
Synonym: Chromosome 22q11.2 Duplication Syndrome
Synonym: Chromosome 22q11.2 Microduplication Syndrome
Synonym: Chromosome 22q11.2 duplication syndrome
Synonym: Chromosome 22q11.2 microduplication syndrome
Tree Number: T10.5.9.5.8
database_cross_reference: DO:DOID:0060436
database_cross_reference: MSH:C567224
database_cross_reference: OMIM:608363
database_cross_reference: SNOMEDCT_US:699311001

chromosome 22q13 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028771
Subclass_of: chromosomal duplication syndrome
Synonym: CHROMOSOME 22q13 DUPLICATION SYNDROME
Tree Number: T10.5.9.5.11
database_cross_reference: DO:DOID:0060437
database_cross_reference: OMIM:615538

lysinuric protein intolerance
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder characterized by the body's inability to effectively break down lysine, arginine and ornithine and by renal hyperdiaminoaciduria, especially lysinuria, and by impaired formation of urea with hyperammonemia after protein ingestion. It has material basis in homozygous or compound heterozygous mutation in the amino acid transporter gene SLC7A7 on chromosome 14q11.
PMOID: PMO:00029191
Subclass_of: amino acid metabolic disorder
Synonym: Congenital lysinuria
Synonym: DIBASIC AMINO ACIDURIA II
Synonym: Dibasic Amino Aciduria II
Synonym: Hyperdibasic Aminoaciduria
Synonym: Hyperdibasic aminoaciduria
Synonym: Hyperdibasic aminoaciduria, NOS
Synonym: LPI
Synonym: LPI - Lysinuric Protein Intolerance
Synonym: LPI - Lysinuric protein intol
Synonym: LPI - Lysinuric protein intolerance
Tree Number: T10.6.2.15.13
database_cross_reference: DO:DOID:0060439
database_cross_reference: MDR:10058300
database_cross_reference: MEDCIN:93317
database_cross_reference: MSH:C562687
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C121563
database_cross_reference: OMIM:222700
database_cross_reference: OMIM:603593
database_cross_reference: RCD:X40Sk
database_cross_reference: SNMI:D6-B8300
database_cross_reference: SNOMEDCT_US:13138006
database_cross_reference: SNOMEDCT_US:236476008
database_cross_reference: SNOMEDCT_US:237943005
database_cross_reference: SNOMEDCT_US:303852004
database_cross_reference: SNOMEDCT_US:367410007

chromosome 2q31.1 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028772
Subclass_of: chromosomal duplication syndrome
Synonym: CHROMOSOME 2q31.1 DUPLICATION SYNDROME
Synonym: MESOMELIC DYSPLASIA, 2q31.1 DUPLICATION-RELATED
Tree Number: T10.5.9.5.12
database_cross_reference: DO:DOID:0060458
database_cross_reference: OMIM:613681

chromosome 3q29 microduplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028773
Subclass_of: chromosomal duplication syndrome
Synonym: 3q29 microduplication
Synonym: CHROMOSOME 3q29 DUPLICATION SYNDROME
Synonym: Chromosome 3q29 Duplication Syndrome
Synonym: Chromosome 3q29 duplication syndrome
Synonym: Chromosome 3q29 duplication syndrome (disorder)
Synonym: MICRODUPLICATION 3q29 SYNDROME
Synonym: Microduplication 3q29 Syndrome
Synonym: Trisomy 3q29
Synonym: trisomy 3q29
Tree Number: T10.5.9.5.13
database_cross_reference: DO:DOID:0060459
database_cross_reference: MSH:C567626
database_cross_reference: OMIM:611936
database_cross_reference: SNOMEDCT_US:717973004

chromosome 5p13 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028766
Subclass_of: chromosomal duplication syndrome
Synonym: 5p13 microduplication syndrome
Synonym: CHROMOSOME 5p13 DUPLICATION SYNDROME
Synonym: Chromosome 5p13 Duplication Syndrome
Synonym: trisomy 5p13
Tree Number: T10.5.9.5.6
database_cross_reference: DO:DOID:0060460
database_cross_reference: MSH:C567717
database_cross_reference: OMIM:613174

chromosome Xp11.23-p11.22 duplication syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028770
Subclass_of: chromosomal duplication syndrome
Synonym: CHROMOSOME Xp11.23-p11.22 DUPLICATION SYNDROME
Synonym: Chromosome Xp11.23-P11.22 Duplication Syndrome
Synonym: microduplication Xp11.22-p11.23 syndrome
Synonym: trisomy Xp11.22-p11.23
Tree Number: T10.5.9.5.10
database_cross_reference: DO:DOID:0060461
database_cross_reference: MSH:C567585
database_cross_reference: OMIM:300801

Miller-Dieker lissencephaly syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by classical lissencephaly and distinct facial features. Visible and submicroscopic deletions of 17p13.3, including the LIS1 gene, are found in almost 100% of patients.
PMOID: PMO:00025119
Subclass_of: syndrome
Synonym: CHROMOSOME 17p13.3 DELETION SYNDROME
Synonym: Chromosome 17p13.3 Deletion Syndrome
Synonym: Lissencephaly Syndrome, Miller Dieker
Synonym: Lissencephaly Syndrome, Miller-Dieker
Synonym: Lissencephaly syndrome
Synonym: Lissencephaly, Miller Dieker
Synonym: Lissencephaly, Miller-Dieker
Synonym: MDLS
Synonym: MDS
Synonym: MILLER-DIEKER LISSENCEPHALY SYNDROME
Tree Number: T10.1.4
database_cross_reference: CHV:0000025854
database_cross_reference: DO:DOID:0060469
database_cross_reference: ICD10CM:Q93.88
database_cross_reference: JABL:456
database_cross_reference: MDR:10068361
database_cross_reference: MEDCIN:312752
database_cross_reference: MSH:D054221
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:758.33
database_cross_reference: NCI:C124852
database_cross_reference: OMIM:247200
database_cross_reference: RCD:X77r4
database_cross_reference: SNMI:D4-00610
database_cross_reference: SNOMEDCT_US:204036008
database_cross_reference: SNOMEDCT_US:253148005
database_cross_reference: SNOMEDCT_US:43849007

fetal valproate syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by distinctive facial appearance, a cluster of minor and major anomalies and central nervous system dysfunction.
PMOID: PMO:00025216
Subclass_of: syndrome
Synonym: Cong malform due to valproate
Synonym: Congenital malformation due to valproate
Synonym: Dalpro, Fetal Effects From
Synonym: Epival, Fetal Effects From
Synonym: FETAL VALPROATE SYNDROME
Synonym: FVS
Synonym: Fetal Valproate Syndrome
Synonym: Fetal valproate syndrome
Synonym: Fetal valproate syndrome (disorder)
Synonym: Fetal valproic syndrome
Tree Number: T10.1.84
database_cross_reference: CHV:0000023663
database_cross_reference: DO:DOID:0060471
database_cross_reference: JABL:295
database_cross_reference: MDR:10016524
database_cross_reference: MDR:10016870
database_cross_reference: MSH:C536525
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98930
database_cross_reference: NCI_NICHD:C98930
database_cross_reference: OMIM:609442
database_cross_reference: RCD:X78EE
database_cross_reference: SNMI:D4-01822
database_cross_reference: SNOMEDCT_US:17231009
database_cross_reference: SNOMEDCT_US:205792006

Kindler syndrome
type: Class
subclass of: skin disease
definition: A skin disease characterized by congenital blistering, skin atrophy, photosensitivity, skin fragility, and scaling.
PMOID: PMO:00033888
Subclass_of: skin disease
Synonym: BULLOUS ACROKERATOTIC POIKILODERMA OF KINDLER AND WEARY
Synonym: Bullous acrokeratotic poikiloderma of kindler and weary
Synonym: Congenital bullous poikiloderma
Synonym: KINDLER SYNDROME
Synonym: KNDLRS
Synonym: Kindler's syndrome
Synonym: Kindler's syndrome (disorder)
Synonym: POIKILODERMA, CONGENITAL, WITH BULLAE, WEARY TYPE
Synonym: POIKILODERMA, HEREDITARY ACROKERATOTIC
Synonym: Poikiloderma of Kindler
Tree Number: T10.8.12.2.21
database_cross_reference: DO:DOID:0060472
database_cross_reference: MSH:C536321
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:173650
database_cross_reference: OMIM:607900
database_cross_reference: RCD:X50Ck
database_cross_reference: SNOMEDCT_US:238836000

Kabuki syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by multiple congenital anomalies and mental retardation. Other characteristics include a peculiar facial gestalt, short stature, skeletal and visceral abnormalities, cardiac anomalies, and immunological defects.
PMOID: PMO:00025161
Subclass_of: syndrome
Synonym: KABUK1
Synonym: KABUKI MAKE-UP SYNDROME
Synonym: KABUKI SYNDROME
Synonym: KABUKI SYNDROME 1
Synonym: KMS
Synonym: Kabuki Make-Up Syndrome
Synonym: Kabuki Makeup Syndrome
Synonym: Kabuki Syndrome
Synonym: Kabuki make up syndrome
Synonym: Kabuki make-up syndrome
Tree Number: T10.1.42
database_cross_reference: CHV:0000048952
database_cross_reference: DO:DOID:0060473
database_cross_reference: JABL:377
database_cross_reference: MDR:10063935
database_cross_reference: MDR:10063936
database_cross_reference: MEDCIN:312330
database_cross_reference: MSH:C537705
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124837
database_cross_reference: OMIM:147920
database_cross_reference: OMIM:602113
database_cross_reference: SNOMEDCT_US:205805008
database_cross_reference: SNOMEDCT_US:313426007

Perlman syndrome
type: Class
subclass of: syndrome
definition: A kidney cancer that affects the kidneys and typically located_in children.
PMOID: PMO:00025149
Subclass_of: syndrome
Synonym: Embryonal Nephroma
Synonym: Embryonal adenosarcoma
Synonym: Embryonal nephroma
Synonym: KIDNEY, ADENOMYOSARCOMA, EMBRYONAL
Synonym: KIDNEY, CARCINOSARCOMA, EMBRYONAL
Synonym: KIDNEY, EMBRYOMA
Synonym: KIDNEY, EMBRYONAL MIXED TUMOR
Synonym: Kidney Wilms Tumor
Synonym: NEPHROBLASTOMA
Synonym: NEPHROBLASTOMA, MALIGNANT
Tree Number: T10.1.31
database_cross_reference: AOD:0000004550
database_cross_reference: AOD:0000023021
database_cross_reference: CCPSS:0048278
database_cross_reference: CHV:0000008581
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2021-2990
database_cross_reference: CSP:4001-0143
database_cross_reference: CST:CARCINOMA
database_cross_reference: DO:DOID:2154
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002025
database_cross_reference: HPO:HP:0002667
database_cross_reference: ICD10AM:M8960/3
database_cross_reference: LCH_NW:sh85090858
database_cross_reference: MDR:10029145
database_cross_reference: MDR:10047985
database_cross_reference: MDR:10047986
database_cross_reference: MDR:10047987
database_cross_reference: MEDCIN:31531
database_cross_reference: MEDLINEPLUS:3075
database_cross_reference: MSH:D009396
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3267
database_cross_reference: NCI:C40407
database_cross_reference: NCI_CDISC:C40407
database_cross_reference: NCI_CTEP-SDC:10029145
database_cross_reference: NCI_NCI-GLOSS:CDR0000045946
database_cross_reference: NCI_NICHD:C3267
database_cross_reference: NCI_NICHD:C40407
database_cross_reference: NDFRT:N0000171666
database_cross_reference: OMIM:194070
database_cross_reference: OMIM:600185
database_cross_reference: OMIM:607102
database_cross_reference: OMIM:MTHU005880
database_cross_reference: OMIM:MTHU006873
database_cross_reference: OMIM:MTHU010520
database_cross_reference: PDQ:CDR0000042957
database_cross_reference: RCD:BBLE.
database_cross_reference: RCD:Xa9A0
database_cross_reference: RCDAE:Xa9A0
database_cross_reference: RCDSY:BBLE.
database_cross_reference: SNM:M-8960/3
database_cross_reference: SNMI:M-89603
database_cross_reference: SNOMEDCT_US:25081006
database_cross_reference: SNOMEDCT_US:302849000
database_cross_reference: SNOMEDCT_US:31470003

Zika fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that has_material_basis in Zika virus, which is transmitted_by Aedes aegypti mosquitoes and targets neural progenitor cells and neuronal cells in all stages of maturity and has_symptom fever, has_symptom rash, has_symptom headaches and has_symptom joint pain.
PMOID: PMO:00029354
Subclass_of: viral infectious disease
Synonym: Zika virus disease
Tree Number: T10.7.2.7
database_cross_reference: DO:DOID:0060478

Shwachman-Diamond syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by exocrine pancreatic insufficiency, bone marrow failure and skeletal abnormalities.
PMOID: PMO:00025226
Subclass_of: syndrome
Synonym: Congenital Lipomatosis of Pancreas
Synonym: Congenital lipomatosis of pancreas
Synonym: LIPOMATOSIS OF PANCREAS, CONGENITAL
Synonym: Lipomatosis of pancreas, congenital
Synonym: Metaph dysplas+malab+neutropen
Synonym: Metaphys chondrodys, Shwachman
Synonym: Metaphyseal Chondrodysplasia, Shwachman Type
Synonym: Metaphyseal chondrodysplasia with pancreatic insufficiency AND neutropenia
Synonym: Metaphyseal chondrodysplasia with pancreatic insufficiency and neutropenia
Synonym: Metaphyseal chondrodysplasia, Shwachman type
Tree Number: T10.1.90
database_cross_reference: CHV:0000026699
database_cross_reference: DO:DOID:0060479
database_cross_reference: MDR:10067940
database_cross_reference: MEDCIN:312853
database_cross_reference: MSH:C537330
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C61235
database_cross_reference: NCI_NCI-GLOSS:CDR0000644775
database_cross_reference: NCI_NCI-GLOSS:CDR0000644776
database_cross_reference: NCI_NCI-GLOSS:CDR0000644777
database_cross_reference: OMIM:260400
database_cross_reference: OMIM:607444
database_cross_reference: PDQ:CDR0000285969
database_cross_reference: RCD:X20Ha
database_cross_reference: SNM:D-6444
database_cross_reference: SNMI:D4-00A58
database_cross_reference: SNMI:DC-41280
database_cross_reference: SNOMEDCT_US:23185001
database_cross_reference: SNOMEDCT_US:234420003
database_cross_reference: SNOMEDCT_US:254086005
database_cross_reference: SNOMEDCT_US:89454001

Goldberg-Shprintzen syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by intellectual disability, specific facial gestalt and Hirschsprung's disease (HSCR). It has material basis in homozygous mutation in the KIAA1279 gene on chromosome 10q21.1.
PMOID: PMO:00025122
Subclass_of: syndrome
Synonym: GOLDBERG-SHPRINTZEN MEGACOLON SYNDROME
Synonym: GOLDBERG-SHPRINTZEN SYNDROME
Synonym: GOSHS
Synonym: Goldberg Shprintzen megacolon syndrome
Synonym: Goldberg Shprintzen megacolon syndrome (disorder)
Synonym: Goldberg-Shprintzen megacolon syndrome
Synonym: Megacolon microcephaly syndrome
Tree Number: T10.1.7
database_cross_reference: DO:DOID:0060481
database_cross_reference: MSH:C537279
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:609367
database_cross_reference: OMIM:609460
database_cross_reference: SNOMEDCT_US:717822006

oculoauricular syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by microcornea, microphthalmia, anterior-segment dysgenesis, cataract, coloboma of various parts of the eye, abnormalities of the retinal pigment epithelium, and rod-cone dystrophy and a particular cleft ear lobule.
PMOID: PMO:00025125
Subclass_of: syndrome
Synonym: MICROPHTHALMIA, MICROCORNEA, ANTERIOR SEGMENT DYSGENESIS, CATARACT, OCULAR COLOBOMA, RETINAL PIGMENT EPITHELIUM ABNORMALITIES, ROD-CONE DYSTROPHY, AND ANOMALIES OF THE EXTERNAL EAR
Synonym: OCACS
Synonym: OCULOAURICULAR SYNDROME
Synonym: Oculoauricular Syndrome
Synonym: SCHORDERET-MUNIER-FRANCESCHETTI SYNDROME
Tree Number: T10.1.10
database_cross_reference: DO:DOID:0060482
database_cross_reference: MSH:C567416
database_cross_reference: OMIM:142992
database_cross_reference: OMIM:612109

MEDNIK syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma. It is cause by homozygous mutation in the AP1S1 gene on chromosome 7q22.
PMOID: PMO:00025120
Subclass_of: syndrome
Synonym: EKV3
Synonym: ERYTHROKERATODERMIA VARIABILIS 3
Synonym: ERYTHROKERATODERMIA VARIABILIS 3 (disorder)
Synonym: ERYTHROKERATODERMIA VARIABILIS, KAMOURASKA TYPE
Synonym: Erythrokeratodermia Variabilis 3
Synonym: Erythrokeratodermia Variabilis, Kamouraska Type
Synonym: Erythrokeratodermia variabilis 3
Synonym: Erythrokeratodermia variabilis Kamouraska type
Synonym: Intellectual disability, enteropathy, deafness, peripheral neuropathy, ichthyosis, keratoderma syndrome
Synonym: Intellectual disability, enteropathy, deafness, peripheral neuropathy, ichthyosis, keratoderma syndrome (disorder)
Tree Number: T10.1.5
database_cross_reference: DO:DOID:0060483
database_cross_reference: MSH:C563739
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:603531
database_cross_reference: OMIM:609313
database_cross_reference: SNOMEDCT_US:722035007

EAST syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterize by seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance. It has material basis in homozygous or compound heterozygous mutation in the KCNJ10 gene on chromosome 1q23.
PMOID: PMO:00025243
Subclass_of: syndrome
Synonym: SeSAME syndrome
Synonym: epilepsy, ataxia, sensorineural deafness and tubulopathy
Synonym: seizures, sensorineural deafness, ataxia, mental retardation and electrolyte imbalance
Tree Number: T10.1.103
database_cross_reference: DO:DOID:0060484

Mowat-Wilson syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows, medially flaring and sparse in the middle part, hypertelorism, deep set but large eyes, large and uplifted ear lobes, with a central depression, saddle nose with prominent rounded nasal tip, prominent columella, open mouth, with M-shaped upper lip, frequent smiling, and a prominent but narrow and triangular pointed chin), moderate-to-severe intellectual deficiency, epilepsy and variable congenital malformations including Hirschsprung disease, genitourinary anomalies (in particular hypospadias in males), congenital heart defects, agenesis of the corpus callosum and eye anomalies. It has material basis in de novo heterozygous mutation in the ZEB2 gene on chromosome 2q22.
PMOID: PMO:00025242
Subclass_of: syndrome
Synonym: HIRSCHSPRUNG DISEASE-MENTAL RETARDATION SYNDROME
Synonym: Hirschsprung Disease-Mental Retardation Syndrome
Synonym: Hirschsprung disease mental retardation syndrome
Synonym: Hirschsprung disease-mental retardation syndrome
Synonym: MICROCEPHALY, MENTAL RETARDATION, AND DISTINCT FACIAL FEATURES, WITH OR WITHOUT HIRSCHSPRUNG DISEASE
Synonym: MOWAT-WILSON SYNDROME
Synonym: MOWS
Synonym: Microcephaly, Mental Retardation, and Distinct Facial Features, with Or without Hirschsprung Disease
Synonym: Microcephaly, mental retardation and distinct features, with or without Hirschsprung disease
Synonym: Mowat-Wilson Syndrome
Tree Number: T10.1.102
database_cross_reference: DO:DOID:0060485
database_cross_reference: MSH:C536990
database_cross_reference: NCI:C74999
database_cross_reference: OMIM:235730
database_cross_reference: OMIM:605802
database_cross_reference: SNOMEDCT_US:703535000

Perry syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by parkinsonism, hypoventilation, depression, and weight loss; that has material basis in heterozygous mutation in the DCTN1 gene on chromosome 2p13.. The mean age at onset is 48 years; the mean disease duration is five years. Parkinsonism and psychiatric changes (depression, apathy, character changes, and withdrawal) tend to occur early; severe weight loss and hypoventilation manifest later.
PMOID: PMO:00025116
Subclass_of: syndrome
Synonym: PARKINSONISM WITH ALVEOLAR HYPOVENTILATION AND MENTAL DEPRESSION
Synonym: PERRY SYNDROME
Synonym: Parkinsonism with Alveolar Hypoventilation and Mental Depression
Synonym: Parkinsonism with alveolar hypoventilation and mental depression
Synonym: Perry Syndrome
Synonym: Perry syndrome (disorder)
Synonym: parkinsonism with alveolar hypoventilation and mental depression
Tree Number: T10.1.1
database_cross_reference: DO:DOID:0060486
database_cross_reference: MSH:C566822
database_cross_reference: OMIM:168605
database_cross_reference: OMIM:601143
database_cross_reference: SNOMEDCT_US:699184009

Pitt-Hopkins syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by intellectual disability and developmental delay, breathing problems, recurrent seizures (epilepsy), and distinctive facial features. It has material basis in heterozygous de novo mutations in the TCF4 gene in chromosome 18q21.
PMOID: PMO:00025134
Subclass_of: syndrome
Synonym: ENCEPHALOPATHY, SEVERE EPILEPTIC, WITH AUTONOMIC DYSFUNCTION
Synonym: Encephalopathy, Severe Epileptic, With Autonomic Dysfunction
Synonym: MENTAL RETARDATION, SYNDROMAL, WITH INTERMITTENT HYPERVENTILATION
Synonym: Mental Retardation, Syndromal, With Intermittent Hyperventilation
Synonym: PITT-HOPKINS SYNDROME
Synonym: PTHS
Synonym: PTHS - Pitt-Hopkins syndrome
Synonym: Pitt Hopkins syndrome
Synonym: Pitt-Hopkins syndrome (disorder)
Tree Number: T10.1.19
database_cross_reference: DO:DOID:0060488
database_cross_reference: MSH:C537403
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:602272
database_cross_reference: OMIM:610954
database_cross_reference: SNOMEDCT_US:702344008

Warsaw breakage syndrome
type: Class
subclass of: syndrome
definition: A syndrome mainly characterized by severe growth retardation and microcephaly. It is a new form of cohesinopathy showing defects in sister chromatid cohesion and hypersensitivity to chemicals that induce replication stress, thus combining distinct cytogenetic features seen in Roberts syndrome and Fanconi anemia, respectively. It has material basis in homozygous or compound heterozygous mutation in the DDX11 gene on chromosome 12p11.
PMOID: PMO:00025217
Subclass_of: syndrome
Synonym: WABS
Synonym: WARSAW BREAKAGE SYNDROME
Synonym: Warsaw breakage syndrome (disorder)
Tree Number: T10.1.85
database_cross_reference: DO:DOID:0060535
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:601150
database_cross_reference: OMIM:613398
database_cross_reference: SNOMEDCT_US:702829000

mitochondrial complex I deficiency
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028982
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL COMPLEX I DEFICIENCY
Synonym: Mitochondrial complex I deficiency
Tree Number: T10.6.2.1.19
database_cross_reference: MSH:C537475
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:157655
database_cross_reference: OMIM:161015
database_cross_reference: OMIM:252010
database_cross_reference: OMIM:300078
database_cross_reference: OMIM:516000
database_cross_reference: OMIM:516001
database_cross_reference: OMIM:516002
database_cross_reference: OMIM:516003
database_cross_reference: OMIM:590010
database_cross_reference: OMIM:600532
database_cross_reference: OMIM:601445
database_cross_reference: OMIM:602141
database_cross_reference: OMIM:602694
database_cross_reference: OMIM:602985
database_cross_reference: OMIM:603835
database_cross_reference: OMIM:603839
database_cross_reference: OMIM:603846
database_cross_reference: OMIM:603848
database_cross_reference: OMIM:606934
database_cross_reference: OMIM:609653
database_cross_reference: OMIM:611776
database_cross_reference: OMIM:612360
database_cross_reference: OMIM:612638
database_cross_reference: OMIM:612911
database_cross_reference: OMIM:613621
database_cross_reference: OMIM:613622
database_cross_reference: OMIM:615533
database_cross_reference: OMIM:MTHU047303

mitochondrial complex II deficiency
type: Class
subclass of: mitochondrial metabolism disease
definition: A mitochondrial metabolism disease characerized by a highly variable phenotype. Some patients have multisystem involvement of the brain, heart, muscle, liver, and kidneys resulting in death in infancy, whereas others have only isolated cardiac or muscle involvement with onset in adulthood and normal cognition. It has material basis in homozygous or compound heterozygous mutation in the nuclear-encoded SDHA gene on chromosome 5p, the nuclear-encoded SDHAF1 gene on chromosome 19q, or the nuclear-encoded SDHD gene on chromosome 11q23.
PMOID: PMO:00028990
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL COMPLEX II DEFICIENCY
Synonym: Mitochondrial Complex II Deficiency
Synonym: SUCCINATE CoQ REDUCTASE DEFICIENCY
Synonym: Succinate CoQ Reductase Deficiency
Synonym: isolated mitochondrial respiratory chain complex II deficiency
Synonym: isolated succinate-CoQ reductase deficiency
Synonym: isolated succinate-coenzyme Q reductase deficiency
Synonym: isolated succinate-ubiquinone reductase deficiency
Tree Number: T10.6.2.1.27
database_cross_reference: DO:DOID:0060537
database_cross_reference: MSH:C565375
database_cross_reference: OMIM:252011
database_cross_reference: OMIM:600857
database_cross_reference: OMIM:602690
database_cross_reference: OMIM:612848

Barber-Say syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by d by the association of excessive hair growth (hypertrichosis), papery thin and fragile (atrophic) skin, outward turned eyelids (ectropion) and a large mouth (macrostomia). It is that has material basis in heterozygous mutation in the TWIST2 gene on chromosome 2q37.
PMOID: PMO:00025227
Subclass_of: syndrome
Synonym: BARBER-SAY SYNDROME
Synonym: BBRSAY
Synonym: BSS
Synonym: Barber Say syndrome
Synonym: Barber-Say Syndrome
Synonym: Barber-Say syndrome (disorder)
Synonym: Bss
Synonym: HYPERTRICHOSIS, ATROPHIC SKIN, ECTROPION, AND MACROSTOMIA
Synonym: Hypertrichosis, atrophic skin, ectropion, and macrostomia
Tree Number: T10.1.91
database_cross_reference: DO:DOID:0060549
database_cross_reference: DRUGBANK:DB00761
database_cross_reference: DRUGBANK:DB01164
database_cross_reference: DRUGBANK:DB09153
database_cross_reference: DRUGBANK:DB09154
database_cross_reference: DRUGBANK:DB09395
database_cross_reference: DRUGBANK:DB09407
database_cross_reference: MSH:C537908
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:209885
database_cross_reference: OMIM:607556
database_cross_reference: SNOMEDCT_US:408537003

ablepharon macrostomia syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by by the association of ablepharon, macrostomia, abnormal external ears, syndactyly of the hands and feet, skin findings (such as dry and coarse skin or redundant folds of skin), absent or sparse hair, genital malformations and developmental delay. Other reported manifestations include malar hypoplasia, absent or hypoplastic nipples, umbilical abnormalities and growth retardation. It is that has material basis in heterozygous mutation in the TWIST2 gene on chromosome 2q37.
PMOID: PMO:00025195
Subclass_of: syndrome
Synonym: ABLEPHARON-MACROSTOMIA SYNDROME
Synonym: AMS
Synonym: Ablepharon macrostomia syndrome
Synonym: Ablepharon macrostomia syndrome (disorder)
Synonym: Ablepharon-Macrostomia Syndrome
Synonym: poikiloderma with neutropenia, Clericuzio type
Tree Number: T10.1.73
database_cross_reference: DO:DOID:0060550
database_cross_reference: MSH:C535557
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:200110
database_cross_reference: OMIM:607556
database_cross_reference: SNOMEDCT_US:718575002

poikiloderma with neutropenia
type: Class
subclass of: skin disease
definition: A skin disease characterized by poikiloderma, hyperkeratotic nails, generalized hyperkeratosis on palms and soles, neutropenia, short stature, and recurrent pulmonary infections. It has material basis in mutation in the C16ORF57 gene on chromosome 16q13.
PMOID: PMO:00033879
Subclass_of: skin disease
Synonym: PN
Synonym: POIKILODERMA WITH NEUTROPENIA
Synonym: POIKILODERMA WITH NEUTROPENIA, CLERICUZIO-TYPE
Synonym: Poikiloderma with Neutropenia
Synonym: Poikiloderma with Neutropenia, Clericuzio-Type
Tree Number: T10.8.12.2.16
database_cross_reference: DO:DOID:0060551
database_cross_reference: MSH:C565820
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:604173
database_cross_reference: OMIM:613276

lethal congenital contracture syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by congenital nonprogressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth.
PMOID: PMO:00025219
Subclass_of: syndrome
Synonym: Cong deformity-clavicle
Synonym: Congenit deformity of clavicle
Synonym: Congenital deformity of clavicle
Synonym: Congenital deformity of clavicle (disorder)
Synonym: Congenital deformity of clavicle, NOS
Synonym: Israeli Bedouin type B multiple contracture syndrome
Synonym: congenital deformity of clavicle
Synonym: congenital deformity of clavicle (diagnosis)
Synonym: lethal congenital contracture syndrome 3
Tree Number: T10.1.87
database_cross_reference: DO:DOID:0060558
database_cross_reference: DO:DOID:0060653
database_cross_reference: ICD10CM:Q68.8
database_cross_reference: ICD9CM:755.51
database_cross_reference: MDR:10010434
database_cross_reference: MEDCIN:211306
database_cross_reference: RCD:XE1Lt
database_cross_reference: SNMI:D4-13020
database_cross_reference: SNOMEDCT_US:205251003
database_cross_reference: SNOMEDCT_US:7921007

lethal congenital contracture syndrome 1
type: Class
subclass of: lethal congenital contracture syndrome
definition: A lethal congenital contracture syndrome that has material basis in homozygous or compound heterozygous mutation in the mRNA export mediator GLE1 on chromosome 9q34.
PMOID: PMO:00025220
Subclass_of: lethal congenital contracture syndrome
Synonym: Herva disease
Synonym: LCCS
Synonym: LCCS1
Synonym: LETHAL CONGENITAL CONTRACTURE SYNDROME 1
Synonym: Lethal autosomal recessive syndrome of multiple congenital contractures
Synonym: Lethal congenital contracture syndrome 1
Synonym: Lethal congenital contracture syndrome type 1
Synonym: Lethal congenital contracture syndrome type 1 (disorder)
Synonym: MULTIPLE CONTRACTURE SYNDROME, FINNISH TYPE
Synonym: Multiple contracture syndrome Finnish type
Tree Number: T10.1.87.1
database_cross_reference: DO:DOID:0060559
database_cross_reference: MSH:C537194
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:253310
database_cross_reference: OMIM:603371
database_cross_reference: SNOMEDCT_US:715418007

lethal congenital contracture syndrome 2
type: Class
subclass of: lethal congenital contracture syndrome
definition: A lethal congenital contracture syndrome that can be that has material basis in homozygous mutation in the ERBB3 gene on chromosome 12q13.
PMOID: PMO:00025221
Subclass_of: lethal congenital contracture syndrome
Synonym: LCCS2
Synonym: LETHAL CONGENITAL CONTRACTURE SYNDROME 2
Synonym: Lethal Congenital Contracture Syndrome 2
Synonym: MULTIPLE CONTRACTURE SYNDROME, ISRAELI BEDOUIN TYPE A
Synonym: Multiple Contracture Syndrome, Israeli Bedouin Type A
Synonym: multiple contracture syndrome, Israeli-Bedouin type
Tree Number: T10.1.87.2
database_cross_reference: DO:DOID:0060560
database_cross_reference: MSH:C564369
database_cross_reference: OMIM:190151
database_cross_reference: OMIM:607598

spinal disease
type: Class
subclass of: musculoskeletal system disease
PMOID: PMO:00032320
Subclass_of: musculoskeletal system disease
Synonym: 1-23 DISORDERS OF THE VERTEBRAL COLUMN
Synonym: DISORDERS OF THE VERTEBRAL COLUMN
Synonym: Disease, Spinal
Synonym: Diseases, Spinal
Synonym: Disorder of spinal column
Synonym: Disorder of spinal column (disorder)
Synonym: Disorder of spine
Synonym: Disorder of spine (disorder)
Synonym: Disorder of the vertebral column
Synonym: Disorder of the vertebral column (disorder)
Tree Number: T10.8.4.2
database_cross_reference: CCPSS:0019641
database_cross_reference: CCPSS:0022731
database_cross_reference: CHV:0000011618
database_cross_reference: CSP:2715-3069
database_cross_reference: DO:DOID:0060564
database_cross_reference: ICD10:M45-M49.9
database_cross_reference: ICD10:M48.9
database_cross_reference: ICD10AM:M45-M49.9
database_cross_reference: ICD10AM:M48.9
database_cross_reference: ICD10CM:M45-M49
database_cross_reference: ICD10CM:M48.9
database_cross_reference: LCH_NW:sh85126698
database_cross_reference: MDR:10041565
database_cross_reference: MDR:10061368
database_cross_reference: MDR:10070759
database_cross_reference: MEDCIN:319358
database_cross_reference: MSH:D013122
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:724.9
database_cross_reference: NDFRT:N0000002797
database_cross_reference: RCD:N1z..
database_cross_reference: RCD:Nyu6.
database_cross_reference: RCD:X70Ca
database_cross_reference: RCD:X70Cm
database_cross_reference: RCD:Xa9Cb
database_cross_reference: RCDSY:Nyu6.
database_cross_reference: SNM:D-3200
database_cross_reference: SNMI:D1-23000
database_cross_reference: SNOMEDCT_US:156617007
database_cross_reference: SNOMEDCT_US:202828002
database_cross_reference: SNOMEDCT_US:202832008
database_cross_reference: SNOMEDCT_US:203810005
database_cross_reference: SNOMEDCT_US:240208001
database_cross_reference: SNOMEDCT_US:240217001
database_cross_reference: SNOMEDCT_US:268071005
database_cross_reference: SNOMEDCT_US:302934007
database_cross_reference: SNOMEDCT_US:367539009
database_cross_reference: SNOMEDCT_US:699699005
database_cross_reference: SNOMEDCT_US:88305002
database_cross_reference: SNOMEDCT_VET:302934007
database_cross_reference: SNOMEDCT_VET:699699005

Ritscher-Schinzel syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by craniofacial (prominent occiputal and forehead, hypertelorism, ocular coloboma, cleft palate), cerebellar (Dandy-Walker malformation, cerebellar vermis hypoplasia) and cardiac (tetralogy of Fallot, atrial and ventricular septal defects) anomalies.
PMOID: PMO:00025233
Subclass_of: syndrome
Synonym: 3C SYNDROME
Synonym: 3C syndrome
Synonym: CCC dysplasia
Synonym: CRANIOCEREBELLOCARDIAC DYSPLASIA
Synonym: Cranio-cerebello-cardiac dysplasia syndrome
Synonym: Cranio-cerebello-cardiac dysplasia syndrome (disorder)
Synonym: Craniocerebellocardiac dysplasia
Synonym: DANDY-WALKER-LIKE MALFORMATION WITH ATRIOVENTRICULAR SEPTAL DEFECT
Synonym: Dandy-Walker-like malformation with atrioventricular septal defect
Synonym: Dandy-Walker-like syndrome
Tree Number: T10.1.95
database_cross_reference: DO:DOID:0060565
database_cross_reference: DO:DOID:0060571
database_cross_reference: JABL:560
database_cross_reference: MSH:C535313
database_cross_reference: OMIM:220210
database_cross_reference: OMIM:610657
database_cross_reference: SNOMEDCT_US:718556007

Holzgreve-Wagner-Rehder Syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by Potter sequence, heart defect, cleft palate, polydactyly, and skeletal defects.
PMOID: PMO:00025150
Subclass_of: syndrome
Synonym: Complex congenital heart defect, renal agenesis, and cleft lip and palate
Synonym: HOLZGREVE SYNDROME
Synonym: Holzgreve Wagner Rehder Syndrome
Synonym: Holzgreve Wagner Rehder syndrome
Synonym: Holzgreve syndrome
Tree Number: T10.1.32
database_cross_reference: DO:DOID:0060566
database_cross_reference: MSH:C535327
database_cross_reference: OMIM:236110

Ritscher-Schinzel syndrome 1
type: Class
subclass of: Ritscher-Schinzel syndrome
definition: A syndrome characterized by craniofacial (prominent occiputal and forehead, hypertelorism, ocular coloboma, cleft palate), cerebellar (Dandy-Walker malformation, cerebellar vermis hypoplasia) and cardiac (tetralogy of Fallot, atrial and ventricular septal defects) anomalies.
PMOID: PMO:00025235
Subclass_of: Ritscher-Schinzel syndrome
Synonym: 3C SYNDROME
Synonym: 3C syndrome
Synonym: CCC dysplasia
Synonym: CRANIOCEREBELLOCARDIAC DYSPLASIA
Synonym: Cranio-cerebello-cardiac dysplasia syndrome
Synonym: Cranio-cerebello-cardiac dysplasia syndrome (disorder)
Synonym: Craniocerebellocardiac dysplasia
Synonym: DANDY-WALKER-LIKE MALFORMATION WITH ATRIOVENTRICULAR SEPTAL DEFECT
Synonym: Dandy-Walker-like malformation with atrioventricular septal defect
Synonym: Dandy-Walker-like syndrome
Tree Number: T10.1.95.2
database_cross_reference: DO:DOID:0060565
database_cross_reference: DO:DOID:0060571
database_cross_reference: JABL:560
database_cross_reference: MSH:C535313
database_cross_reference: OMIM:220210
database_cross_reference: OMIM:610657
database_cross_reference: SNOMEDCT_US:718556007

Ritscher-Schinzel syndrome 2
type: Class
subclass of: Ritscher-Schinzel syndrome
definition: A Ritscher-Schinzel syndrome that has_material_basis_in mutation in the CCDC22 gene on chromosome Xp11.
PMOID: PMO:00025234
Subclass_of: Ritscher-Schinzel syndrome
Synonym: RITSCHER-SCHINZEL SYNDROME 2
Synonym: RTSC2
Tree Number: T10.1.95.1
database_cross_reference: DO:DOID:0060572
database_cross_reference: OMIM:300859
database_cross_reference: OMIM:300963

3MC syndrome 1
type: Class
subclass of: 3MC syndrome
definition: A 3MC syndrome that has_material_basis_in homozygous mutation in the MASP1 gene on chromosome 3q27.
PMOID: PMO:00025194
Subclass_of: 3MC syndrome
Synonym: 3MC SYNDROME 1
Synonym: 3MC1
Synonym: CRANIOSYNOSTOSIS WITH LID ANOMALIES
Synonym: Craniosynostosis with lid anomalies
Synonym: MICHELS SYNDROME, FORMERLY
Synonym: Michels syndrome
Synonym: OCULOPALATOSKELETAL SYNDROME
Synonym: Oculopalatoskeletal syndrome
Synonym: clefting-ocular anterior chamber defect-lid anomalies syndrome
Synonym: craniosynostosis-lid anomalies syndrome
Tree Number: T10.1.72.3
database_cross_reference: DO:DOID:0060575
database_cross_reference: JABL:442
database_cross_reference: MSH:C537738
database_cross_reference: OMIM:257920
database_cross_reference: OMIM:600521

3MC syndrome 2
type: Class
subclass of: 3MC syndrome
definition: A 3MC syndrome that has_material_basis_in homozygous mutation in the COLEC11 gene on chromosome 2p25.
PMOID: PMO:00025193
Subclass_of: 3MC syndrome
Synonym: 3MC SYNDROME 2
Synonym: 3MC2
Synonym: CARNEVALE SYNDROME, FORMERLY
Synonym: Carnevale Krajewska Fischetto syndrome
Synonym: Carnevale syndrome
Synonym: OCULO-SKELETAL-ABDOMINAL SYNDROME
Synonym: OSA SYNDROME
Synonym: Oculo-skeletal-abdominal syndrome
Synonym: PTOSIS OF EYELIDS WITH DIASTASIS RECTI AND HIP DYSPLASIA
Synonym: Ptosis of eyelids with diastasis recti and hip dysplasia
Tree Number: T10.1.72.2
database_cross_reference: DO:DOID:0060576
database_cross_reference: JABL:88
database_cross_reference: MSH:C535586
database_cross_reference: OMIM:265050
database_cross_reference: OMIM:612502

3MC syndrome 3
type: Class
subclass of: 3MC syndrome
definition: A 3MC syndrome that has_material_basis_in a compound heterozygous mutation in the COLEC10 gene on chromosome 8q24.
PMOID: PMO:00025192
Subclass_of: 3MC syndrome
Synonym: 3MC SYNDROME 3
Synonym: 3MC syndrome
Synonym: 3MC3
Synonym: FACIAL CLEFTING SYNDROME, GYPSY TYPE
Synonym: Facial clefting syndrome, Gypsy type
Synonym: MALPUECH FACIAL CLEFTING SYNDROME, FORMERLY
Synonym: Malpuech facial clefting syndrome
Synonym: Malpuech syndrome
Synonym: craniofacial-ulnar-renal syndrome
Synonym: facial clefting syndrome, Gypsy type
Tree Number: T10.1.72.1
database_cross_reference: DO:DOID:0060225
database_cross_reference: DO:DOID:0060577
database_cross_reference: JABL:413
database_cross_reference: MSH:C535704
database_cross_reference: OMIM:248340

Noonan syndrome 1
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome that has_material_basis_in the PTPN11 gene on chromosome 12q24.
PMOID: PMO:00025213
Subclass_of: Noonan syndrome
Synonym: Familial Turner Syndrome
Synonym: NOONAN SYNDROME
Synonym: NOONAN SYNDROME 1
Synonym: NS1
Synonym: Noonan Ehmke Syndrome
Synonym: Noonan Syndrome
Synonym: Noonan Syndrome 1
Synonym: Noonan Syndrome [Disease/Finding]
Synonym: Noonan syndrome
Synonym: Noonan syndrome (disorder)
Tree Number: T10.1.82.9
database_cross_reference: CCPSS:0057183
database_cross_reference: CHV:0000008767
database_cross_reference: DO:DOID:0060578
database_cross_reference: DO:DOID:3490
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001304
database_cross_reference: ICD10CM:Q87.1
database_cross_reference: JABL:487
database_cross_reference: MDR:10029748
database_cross_reference: MEDCIN:33272
database_cross_reference: MSH:D009634
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34854
database_cross_reference: NCI:C75459
database_cross_reference: NCI_NICHD:C34854
database_cross_reference: NDFRT:N0000002192
database_cross_reference: OMIM:163950
database_cross_reference: OMIM:176876
database_cross_reference: RCD:PJ630
database_cross_reference: RCD:PKy80
database_cross_reference: SNM:D-5354
database_cross_reference: SNMI:D4-00302
database_cross_reference: SNOMEDCT_US:205684007
database_cross_reference: SNOMEDCT_US:205794007
database_cross_reference: SNOMEDCT_US:205824006
database_cross_reference: SNOMEDCT_US:88327006

Noonan syndrome 2
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome characterized by hypertrophic obstructive cardiomyopathy and that has_material_basis_in an autosomal recessive inheritance.
PMOID: PMO:00025212
Subclass_of: Noonan syndrome
Synonym: NOONAN SYNDROME 2
Synonym: NOONAN SYNDROME, AUTOSOMAL RECESSIVE
Synonym: NS2
Synonym: Noonan Syndrome 2
Synonym: Noonan Syndrome, Autosomal Recessive
Tree Number: T10.1.82.8
database_cross_reference: DO:DOID:0060580
database_cross_reference: MSH:C548081
database_cross_reference: OMIM:605275

Noonan syndrome 3
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome that has_material_basis_in heterozygous mutation in the KRAS gene.
PMOID: PMO:00025211
Subclass_of: Noonan syndrome
Synonym: NOONAN SYNDROME 3
Synonym: NS3
Tree Number: T10.1.82.7
database_cross_reference: DO:DOID:0060581
database_cross_reference: MSH:C537847
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:190070
database_cross_reference: OMIM:609942

Noonan syndrome 4
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome that has_material_basis_in heterozygous mutation in the SOS1 gene on chromosome 2p22.
PMOID: PMO:00025210
Subclass_of: Noonan syndrome
Synonym: NOONAN SYNDROME 4
Synonym: NS4
Synonym: Noonan Syndrome 4
Tree Number: T10.1.82.6
database_cross_reference: DO:DOID:0060582
database_cross_reference: MSH:C548082
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:182530
database_cross_reference: OMIM:610733

Noonan syndrome 5
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome that has_material_basis_in mutation in the RAF1 gene.
PMOID: PMO:00025209
Subclass_of: Noonan syndrome
Synonym: NOONAN SYNDROME 5
Synonym: NS5
Synonym: Noonan Syndrome 5
Tree Number: T10.1.82.5
database_cross_reference: DO:DOID:0060583
database_cross_reference: MSH:C548083
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:164760
database_cross_reference: OMIM:611553

Noonan syndrome 6
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome that has_material_basis in heterozygous mutation in the NRAS gene on chromosome 1p13.
PMOID: PMO:00025208
Subclass_of: Noonan syndrome
Synonym: NOONAN SYNDROME 6
Synonym: NS6
Synonym: Noonan Syndrome 6
Tree Number: T10.1.82.4
database_cross_reference: DO:DOID:0060584
database_cross_reference: MSH:C548084
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:164790
database_cross_reference: OMIM:613224

Noonan syndrome 7
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome that has_material_basis in heterozygous mutation in the BRAF gene.
PMOID: PMO:00025207
Subclass_of: Noonan syndrome
Synonym: NOONAN SYNDROME 7
Synonym: NS7
Tree Number: T10.1.82.3
database_cross_reference: DO:DOID:0060585
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:164757
database_cross_reference: OMIM:613706

Noonan syndrome 8
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome that has_material_basis_in aused by heterozygous mutation in the RIT1 gene on chromosome 1q22.
PMOID: PMO:00025206
Subclass_of: Noonan syndrome
Synonym: NOONAN SYNDROME 8
Synonym: NS8
Tree Number: T10.1.82.2
database_cross_reference: DO:DOID:0060586
database_cross_reference: OMIM:609591
database_cross_reference: OMIM:615355

Noonan syndrome 9
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome that has_material_basis_in heterozygous mutation in the SOS2 gene on chromosome 14q21.
PMOID: PMO:00025205
Subclass_of: Noonan syndrome
Synonym: NOONAN SYNDROME 9
Synonym: NS9
Tree Number: T10.1.82.1
database_cross_reference: DO:DOID:0060587
database_cross_reference: OMIM:601247
database_cross_reference: OMIM:616559

Noonan syndrome 10
type: Class
subclass of: Noonan syndrome
definition: A Noonan syndrome that has_material_basis_in heterozygous mutation in the LZTR1 gene on chromosome 22q11.
PMOID: PMO:00025214
Subclass_of: Noonan syndrome
Synonym: NOONAN SYNDROME 10
Synonym: NS10
Tree Number: T10.1.82.10
database_cross_reference: DO:DOID:0060588
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:600574
database_cross_reference: OMIM:616564

Yunis-Varon syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by skeletal defects, including cleidocranial dysplasia and digital anomalies, and severe neurologic involvement with neuronal loss. Enlarged cytoplasmic vacuoles are found in neurons, muscle, and cartilage. It is usually lethal in infancy and has material basis in homozygous or compound heterozygous mutation in the FIG4 gene on chromosome 6q21.
PMOID: PMO:00025166
Subclass_of: syndrome
Synonym: CLEIDOCRANIAL DYSPLASIA WITH MICROGNATHIA, ABSENT THUMBS, AND DISTAL APHALANGIA
Synonym: Cleidocranial Dysplasia with Micrognathia, Absent Thumbs, and Distal Aphalangia
Synonym: Cleidocranial dysplasia, micrognathia, absent thumbs, & distal aphalangia
Synonym: YUNIS-VARON SYNDROME
Synonym: YVS
Synonym: Yunis Varon syndrome
Synonym: Yunis-Varon Syndrome
Synonym: cleidocranial dysplasia with micrognathia, absent thumbs, and distal aphalangia
Synonym: cleidocranial dysplasia-micrognathia-absent thumbs syndrome
Tree Number: T10.1.47
database_cross_reference: DO:DOID:0060589
database_cross_reference: MSH:C536719
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:216340
database_cross_reference: OMIM:609390

XFE progeroid syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by aged bird-like facies, lack of subcutaneous fat, dwarfism, cachexia and microcephaly. Additional features include sun-sensitivity from birth, learning disabilities, hearing loss, and visual impairment. It has material basis in homozygous mutation in the ERCC4 gene on chromosome 16p13.
PMOID: PMO:00025185
Subclass_of: syndrome
Synonym: XFE PROGEROID SYNDROME
Synonym: XFE Progeroid Syndrome
Synonym: XFEPS
Synonym: XPF-ERCC1 PROGEROID SYNDROME
Synonym: XPF-ERCC1 Progeroid Syndrome
Synonym: XPF-ERCC1 progeroid syndrome
Tree Number: T10.1.66
database_cross_reference: DO:DOID:0060590
database_cross_reference: MSH:C567043
database_cross_reference: OMIM:610965

WHIM syndrome
type: Class
subclass of: primary immunodeficiency disease
definition: An immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia, and extensive human papillomavirus (HPV) infection. It has material basis in heterozygous mutation in the CXCR4 gene on chromosome 2q22.
PMOID: PMO:00032648
Subclass_of: primary immunodeficiency disease
Synonym: WARTS, HYPOGAMMAGLOBULINEMIA, INFECTIONS, AND MYELOKATHEXIS SYNDROME
Synonym: WHIM - Warts+hypogammaglobulinaemia+infections+myelokathexis
Synonym: WHIM - Warts+hypogammaglobulinemia+infections+myelokathexis
Synonym: WHIM - Warts, hypogammaglobulinaemia, infections and myelokathexis
Synonym: WHIM - Warts, hypogammaglobulinemia, infections and myelokathexis
Synonym: WHIM SYNDROME
Synonym: WHIM-Warts+hypog'glob+inf+my'k
Synonym: WHIMS
Synonym: Warts+hypog'glob+inf+myelokath
Synonym: Warts, hypogammaglobulinaemia, infections, and myelokathexis
Tree Number: T10.8.6.1.3
database_cross_reference: DO:DOID:0060591
database_cross_reference: MEDCIN:351657
database_cross_reference: MSH:C536697
database_cross_reference: OMIM:162643
database_cross_reference: OMIM:193670
database_cross_reference: RCD:X20HO
database_cross_reference: RCDAE:X20HO
database_cross_reference: SNOMEDCT_US:234571003

Nance-Horan syndrome
type: Class
subclass of: X-linked disease
definition: An X-linked disease that has_material_basis_in mutation in the NHS gene on chromosome Xp22. It is characterized by congenital cataract leading to profound vision loss, characteristic dysmorphic features and dental anomalies.
PMOID: PMO:00028722
Subclass_of: X-linked disease
Synonym: CATARACT, X-LINKED, WITH HUTCHINSONIAN TEETH
Synonym: CATARACT-DENTAL SYNDROME
Synonym: Cataract, X-linked, with Hutchinsonian Teeth
Synonym: Cataract-Dental Syndrome
Synonym: MESIODENS-CATARACT SYNDROME
Synonym: Mesiodens-Cataract Syndrome
Synonym: NANCE-HORAN SYNDROME
Synonym: NHS
Synonym: Nance-Horan syndrome (NHS)
Synonym: Nance-Horan syndrome (disorder)
Tree Number: T10.5.3.4.2
database_cross_reference: DO:DOID:0060599
database_cross_reference: JABL:480
database_cross_reference: MSH:C538336
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300457
database_cross_reference: OMIM:302350
database_cross_reference: SNOMEDCT_US:445257004

alpha-methylacyl-CoA racemase deficiency
type: Class
subclass of: peroxisomal disease
definition: A peroxisomal disease that has_material_basis in homozygous mutation in the AMACR gene on chromosome 5p13.2-q11.1. It is characterized by retinitis pigmentosa resulting in progressive visual failure, learning difficulties, a peripheral neuropathy, and hypogonadism.
PMOID: PMO:00029244
Subclass_of: peroxisomal disease
Synonym: ALPHA-METHYLACYL-CoA RACEMASE DEFICIENCY
Synonym: AMACR
Synonym: AMACR DEFICIENCY
Synonym: AMACR deficiency
Synonym: AMACRD
Synonym: Alpha-Methylacyl-CoA Racemase Deficiency
Synonym: Alpha-methylacyl-CoA racemase deficiency disorder
Synonym: Alpha-methylacyl-CoA racemase deficiency disorder (disorder)
Tree Number: T10.6.2.16.7
database_cross_reference: DO:DOID:0060602
database_cross_reference: MSH:C565768
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C119677
database_cross_reference: OMIM:604489
database_cross_reference: OMIM:614307
database_cross_reference: SNOMEDCT_US:700463002

fetal nicotine spectrum disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of nicotine during pregnancy.
PMOID: PMO:00028117
Subclass_of: specific developmental disorder
Tree Number: T10.3.5.1.12
database_cross_reference: DO:DOID:0060606

megacystis-microcolon-intestinal hypoperistalsis syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by marked dilatation of the bladder and microcolon and decreased intestinal peristalsis.
PMOID: PMO:00025203
Subclass_of: syndrome
Synonym: BERDON SYNDROME
Synonym: Berdon syndrome
Synonym: Berdon's syndrome
Synonym: MEGACYSTIS-MICROCOLON-INTESTINAL HYPOPERISTALSIS SYNDROME
Synonym: MMIH
Synonym: MMIH Syndrome
Synonym: Megacyst,microcoln,hypoper syn
Synonym: Megacystis microcolon intestinal hypoperistalsis syndrome
Synonym: Megacystis, Microcolon, Hypoperistalsis Syndrome
Synonym: Megacystis, Microcolon, Intestinal Hypoperistalsis Syndrome
Tree Number: T10.1.81
database_cross_reference: DO:DOID:0060610
database_cross_reference: MDR:10064596
database_cross_reference: MSH:C536138
database_cross_reference: NCI:C98982
database_cross_reference: NCI_NICHD:C98982
database_cross_reference: OMIM:155310
database_cross_reference: RCD:X783d
database_cross_reference: SNOMEDCT_US:253781004

X-linked cleft palate with or without ankyloglossia
type: Class
subclass of: cleft palate
definition: A cleft palate that has_material_basis in mutation in the TBX22 gene on chromosome Xq21.
PMOID: PMO:00028288
Subclass_of: cleft palate
Synonym: CLEFT PALATE WITH OR WITHOUT ANKYLOGLOSSIA, X-LINKED
Synonym: CLEFT PALATE, X-LINKED
Synonym: CPX
Synonym: Cleft Palate, X-Linked
Synonym: Cleft palate X-linked
Synonym: X-linked cleft palate
Synonym: X-linked cleft palate and ankyloglossia
Tree Number: T10.4.21.1.3
database_cross_reference: DO:DOID:0060613
database_cross_reference: DRUGBANK:DB12946
database_cross_reference: MSH:C536426
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300307
database_cross_reference: OMIM:303400

ulnar-mammary syndrome
type: Class
subclass of: syndrome
definition: A syndrome that has_material_basis_in heterozygous mutation in the TBX3 gene. It is characterized by posterior limb deficiencies or duplications, apocrine/mammary gland hypoplasia and, or dysfunction, abnormal dentition, delayed puberty in males, and genital anomalies.
PMOID: PMO:00025236
Subclass_of: syndrome
Synonym: PALLISTER ULNAR-MAMMARY SYNDROME
Synonym: Pallister ulnar-mammary syndrome
Synonym: SCHINZEL SYNDROME
Synonym: Schinzel syndrome
Synonym: ULNAR-MAMMARY SYNDROME
Synonym: UMS
Synonym: Ulnar mammary syndrome
Synonym: Ulnar mammary syndrome (disorder)
Synonym: Ulnar-mammary syndrome
Synonym: Ulnar-mammary syndrome of Pallister
Tree Number: T10.1.96
database_cross_reference: DO:DOID:0060614
database_cross_reference: MSH:C536937
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:181450
database_cross_reference: OMIM:601621
database_cross_reference: SNOMEDCT_US:700211007

ethylmalonic encephalopathy
type: Class
subclass of: mitochondrial metabolism disease
definition: A mitochondrial metabolism disease that is characterized by neurodevelopmental delay and regression, prominent pyramidal and extrapyramidal signs, recurrent petechiae, orthostatic acrocyanosis, and chronic diarrhea; it has_material_basis_in homozygous or compound heterozygous mutation in the ETHE1 gene, which encodes a mitochondrial matrix protein, on chromosome 19q13.
PMOID: PMO:00028986
Subclass_of: mitochondrial metabolism disease
Synonym: EE
Synonym: ENCEPHALOPATHY, ETHYLMALONIC
Synonym: Encephalopathy, Petechiae, and Ethylmalonic Aciduria
Synonym: Encephalopathy, ethylmalonic
Synonym: Epema Syndrome
Synonym: Ethylmalonic encephalopathy
Synonym: Ethylmalonic encephalopathy (disorder)
Synonym: Syndrome of encephalopathy, petechiae, and ethylmalonic aciduria
Tree Number: T10.6.2.1.23
database_cross_reference: DO:DOID:0060640
database_cross_reference: LNC:LP56993-6
database_cross_reference: MSH:C535737
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:602473
database_cross_reference: OMIM:608451
database_cross_reference: SNOMEDCT_US:811000124106

endocrine-cerebro-osteodysplasia syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by multiple congenital defects in endocrine, cerebral, and skeletal systems leading to neonatal mortality; it has_material_basis_in mutation in the gene encoding intestinal cell kinase (ICK).
PMOID: PMO:00025146
Subclass_of: syndrome
Synonym: ECO
Synonym: ECO syndrome
Synonym: ENDOCRINE-CEREBROOSTEODYSPLASIA
Synonym: Endocrine-Cerebroosteodysplasia
Tree Number: T10.1.28
database_cross_reference: DO:DOID:0060641
database_cross_reference: MSH:C567210
database_cross_reference: OMIM:612325
database_cross_reference: OMIM:612651

chondrodysplasia-pseudohermaphroditism syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by the clinical features of 46,XY complete gonadal dysgenesis in association with severe dwarfism with generalized chondrodysplasia.
PMOID: PMO:00025148
Subclass_of: syndrome
Synonym: CHONDRODYSPLASIA-PSEUDOHERMAPHRODITISM SYNDROME
Synonym: Chondrodysplasia pseudohermaphrodism syndrome
Synonym: Chondrodysplasia pseudohermaphroditism syndrome
Synonym: Chondrodysplasia with disorder of sex development syndrome
Synonym: Chondrodysplasia with disorder of sex development syndrome (disorder)
Synonym: Chondrodysplasia-pseudohermaphroditism syndrome
Synonym: Nivelon Nivelon Mabille syndrome
Synonym: Nivelon-Nivelon-Mabille syndrome
Synonym: Pseudohermaphrodism and chondrodysplasia
Synonym: chondrodysplasia-disorder of sex development syndrome
Tree Number: T10.1.30
database_cross_reference: DO:DOID:0060644
database_cross_reference: JABL:104
database_cross_reference: MSH:C536123
database_cross_reference: OMIM:600092
database_cross_reference: SNOMEDCT_US:720851007

cocoon syndrome
type: Class
subclass of: syndrome
definition: A syndrome that has_material_basis_in homozygous mutation in the CHUK gene on chromosome 10q24 and is characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin.
PMOID: PMO:00025153
Subclass_of: syndrome
Synonym: COCOON SYNDROME
Synonym: FETAL ENCASEMENT SYNDROME
Synonym: fetal encasement syndrome
Tree Number: T10.1.35
database_cross_reference: DO:DOID:0060647
database_cross_reference: OMIM:600664
database_cross_reference: OMIM:613630

dicarboxylic aminoaciduria
type: Class
subclass of: amino acid metabolic disorder
PMOID: PMO:00029194
Subclass_of: amino acid metabolic disorder
Synonym: DCBXA
Synonym: DICARBOXYLIC AMINOACIDURIA
Synonym: Dicarboxylic amino aciduria
Synonym: Dicarboxylic aminoaciduria
Synonym: Dicarboxylic aminoaciduria syndrome
Synonym: Dicarboxylic aminoaciduria syndrome (disorder)
Synonym: Dicarboxylicamino Aciduria
Synonym: Dicarboxylicaminoaciduria
Synonym: GLUTAMATE-ASPARTATE TRANSPORT DEFECT
Synonym: Glutamate and aspartate transport defect
Tree Number: T10.6.2.15.16
database_cross_reference: DO:DOID:0060650
database_cross_reference: MSH:C536171
database_cross_reference: OMIM:133550
database_cross_reference: OMIM:222730
database_cross_reference: SNOMEDCT_US:716747007

lethal congenital contracture syndrome 3
type: Class
subclass of: lethal congenital contracture syndrome
PMOID: PMO:00025222
Subclass_of: lethal congenital contracture syndrome
Synonym: LCCS3
Synonym: LETHAL CONGENITAL CONTRACTURAL SYNDROME 3
Synonym: LETHAL CONGENITAL CONTRACTURE SYNDROME 3
Synonym: Lethal Congenital Contractural Syndrome 3
Synonym: MULTIPLE CONTRACTURE SYNDROME, ISRAELI BEDOUIN TYPE B
Synonym: Multiple Contractural Syndrome, Israeli Bedouin Type B
Tree Number: T10.1.87.3
database_cross_reference: MSH:C566961
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:606102
database_cross_reference: OMIM:611369

lethal congenital contracture syndrome 4
type: Class
subclass of: lethal congenital contracture syndrome
definition: A lethal congenital contracture syndrome that has_material_basis_in homozygous mutation in the MYBPC1 gene on chromosome 12q23.
PMOID: PMO:00025223
Subclass_of: lethal congenital contracture syndrome
Synonym: LCCS4
Synonym: LETHAL CONGENITAL CONTRACTURE SYNDROME 4
Tree Number: T10.1.87.4
database_cross_reference: DO:DOID:0060654
database_cross_reference: OMIM:160794
database_cross_reference: OMIM:614915

autosomal recessive congenital ichthyosis
type: Class
subclass of: skin disease
definition: A skin disease that is characterized by autosomal recessive inheritance and abnormal skin scaling over the whole body due to a defect in keratinization.
PMOID: PMO:00033913
Subclass_of: skin disease
Synonym: ARCI
Tree Number: T10.8.12.2.31
database_cross_reference: DO:DOID:0060655

anencephaly
type: Class
subclass of: congenital nervous system abnormality
definition: A congenital nervous system abnormality characterized by failure of the anterior neuropore to close resulting in partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp.
PMOID: PMO:00028254
Subclass_of: congenital nervous system abnormality
Synonym: ABSENCE OF BRAIN CONGEN
Synonym: ANENCEPHALIA
Synonym: ANENCEPHALUS
Synonym: ANENCEPHALY
Synonym: Absence of Brain, Congenital
Synonym: Agenesis of brain
Synonym: Anencephalia
Synonym: Anencephalias
Synonym: Anencephalic monster
Synonym: Anencephalus
Tree Number: T10.4.1.6
database_cross_reference: AOD:0000006233
database_cross_reference: CCPSS:0003984
database_cross_reference: CHV:0000001138
database_cross_reference: CSP:0723-2890
database_cross_reference: CST:ANOMALY CONGEN CNS
database_cross_reference: DO:DOID:0060668
database_cross_reference: HPO:HP:0002323
database_cross_reference: ICD10:Q00.0
database_cross_reference: ICD10AM:Q00.0
database_cross_reference: ICD10CM:Q00.0
database_cross_reference: ICD9CM:740.0
database_cross_reference: ICPC2P:N85001
database_cross_reference: LCH:U005154
database_cross_reference: LCH_NW:sh85004949
database_cross_reference: LNC:LA20078-4
database_cross_reference: MDR:10002317
database_cross_reference: MDR:10002318
database_cross_reference: MDR:10002320
database_cross_reference: MEDCIN:34538
database_cross_reference: MEDCIN:35749
database_cross_reference: MEDLINEPLUS:340
database_cross_reference: MSH:D000757
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84560
database_cross_reference: NCI_CDISC:C84560
database_cross_reference: NCI_NICHD:C84560
database_cross_reference: NDFRT:N0000000401
database_cross_reference: OMIM:206500
database_cross_reference: OMIM:MTHU011716
database_cross_reference: PSY:02460
database_cross_reference: RCD:P00..
database_cross_reference: RCD:P00z.
database_cross_reference: SNM:M-21510
database_cross_reference: SNMI:D4-F1134
database_cross_reference: SNOMEDCT_US:156885009
database_cross_reference: SNOMEDCT_US:156887001
database_cross_reference: SNOMEDCT_US:203926007
database_cross_reference: SNOMEDCT_US:268306009
database_cross_reference: SNOMEDCT_US:89369001
database_cross_reference: SNOMEDCT_VET:89369001

Brunner Syndrome
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder characterized by recessive X-linked inhetiance, impaired monoamine metabolism, impulsive aggressiveness and mild mental retardation that has_material_basis_in mutation in the MAOA gene on chromosome Xp11.
PMOID: PMO:00029222
Subclass_of: amino acid metabolic disorder
Synonym: BRNRS
Synonym: BRUNNER SYNDROME
Synonym: Brunner syndrome
Synonym: Deficiency of monoamine oxidase A
Synonym: Deficiency of monoamine oxidase A (disorder)
Synonym: Monoamine oxidase A deficiency
Synonym: X-linked monoamine oxidase deficiency
Synonym: brunner syndrome
Synonym: monoamine oxidase A (MAOA) deficiency
Synonym: monoamine oxidase A deficiency
Tree Number: T10.6.2.15.24
database_cross_reference: CHV:0000048965
database_cross_reference: DO:DOID:0060693
database_cross_reference: JABL:81
database_cross_reference: MSH:C563156
database_cross_reference: OMIM:300615
database_cross_reference: OMIM:309850
database_cross_reference: SNOMEDCT_US:718210003

hyperekplexia
type: Class
subclass of: nervous system disease
PMOID: PMO:00029883
Subclass_of: nervous system disease
Synonym: Hyperekplexia
Synonym: Hyperekplexia [Disease/Finding]
Synonym: Hyperekplexias
Synonym: Hyperexplexia
Synonym: Hyperexplexia (finding)
Synonym: Startle disease
Synonym: Startle syndrome
Synonym: hyperexplexia
Synonym: startle disease
Synonym: startle syndrome
Tree Number: T10.8.2.1
database_cross_reference: CHV:0000023257
database_cross_reference: HPO:HP:0002267
database_cross_reference: MDR:10058271
database_cross_reference: MDR:10058274
database_cross_reference: MDR:10058275
database_cross_reference: MSH:D000071017
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000192882
database_cross_reference: OMIM:MTHU044673
database_cross_reference: RCD:X004z
database_cross_reference: SNM:F-81780
database_cross_reference: SNMI:F-A1790
database_cross_reference: SNOMEDCT_US:19557000

hyperekplexia 1
type: Class
subclass of: hyperekplexia
definition: A hyperekplexia that has_material_basis_in heterozygous, homozygous, or compound heterozygous mutation in the GLRA1 gene on chromosome 5q32.
PMOID: PMO:00029885
Subclass_of: hyperekplexia
Synonym: Congenital stiff person syndrome
Synonym: EXAGGERATED STARTLE REACTION
Synonym: Exagerrated startle reflex
Synonym: Familial startle disease
Synonym: HKPX1
Synonym: HYPEREKPLEXIA, HEREDITARY 1
Synonym: Hereditary Hyperexplexia
Synonym: Hyperexplexia hereditary
Synonym: KOK DISEASE
Synonym: Kok disease
Tree Number: T10.8.2.1.2
database_cross_reference: DO:DOID:0060696
database_cross_reference: MSH:C538136
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:149400

hyperekplexia 2
type: Class
subclass of: hyperekplexia
definition: A hyperekplexia that has_material_basis_in compound heterozygous or homozygous mutation in the GLRB gene on chromosome 4q32.
PMOID: PMO:00029886
Subclass_of: hyperekplexia
Synonym: HKPX2
Synonym: HYPEREKPLEXIA 2
Tree Number: T10.8.2.1.3
database_cross_reference: DO:DOID:0060697
database_cross_reference: OMIM:138492
database_cross_reference: OMIM:614619

hyperekplexia 3
type: Class
subclass of: hyperekplexia
definition: A hyperekplexia that has_material_basis_in homozygous or compound heterozygous mutation in the SLC6A5 gene on chromosome 11p15.
PMOID: PMO:00029884
Subclass_of: hyperekplexia
Synonym: HKPX3
Synonym: HYPEREKPLEXIA 3
Tree Number: T10.8.2.1.1
database_cross_reference: DO:DOID:0060698
database_cross_reference: OMIM:614618

lymphoproliferative syndrome
type: Class
subclass of: primary immunodeficiency disease
definition: A primary immunodeficiency disease characterized by immune dysregulation typically after viral infection, usually associated with Epstein-Barr viral infection.
PMOID: PMO:00032674
Subclass_of: primary immunodeficiency disease
Tree Number: T10.8.6.1.5
database_cross_reference: DO:DOID:0060704

NGLY1-deficiency
type: Class
subclass of: carbohydrate metabolic disorder
definition: A carbohydrate metabolic disorder that has_material_basis_in homozygous or compound heterozygous mutation in the NGLY1 gene on chromosome 1p24. It is characterized by global developmental delay, hypotonia, abnormal involuntary movements, and alacrima or poor tear production.
PMOID: PMO:00029129
Subclass_of: carbohydrate metabolic disorder
Synonym: CDDG
Synonym: CDG1V, FORMERLY
Synonym: CONGENITAL DISORDER OF DEGLYCOSYLATION
Synonym: CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Iv, FORMERLY
Synonym: Congenital Disorder of Deglycosylation
Synonym: NGLY1-CDDG
Synonym: congenital disorder of deglycosylation
Synonym: congenital disorder of glycosylation type Iv
Synonym: deficiency of N-glycanase 1
Tree Number: T10.6.2.11.8
database_cross_reference: DO:DOID:0060728
database_cross_reference: NCI:C126746
database_cross_reference: OMIM:610661
database_cross_reference: OMIM:615273

chromosome 9p deletion syndrome
type: Class
subclass of: chromosomal deletion syndrome
definition: A chromosome deletion syndrome characterized by trigonocephaly, flattened occiput midface hypoplasia, long philtrum, prominent forehead, broad flat nasal bridge, anteverted nares, malformed external ears, hypertelorism, hypertonia, delayed psychomotor development and that has_material_basis_in a contiguous gene deletion on the short arm of chromosome 9.
PMOID: PMO:00028794
Subclass_of: chromosomal deletion syndrome
Synonym: 9p deletion chromosome syndrome
Synonym: 9p deletion syndrome
Synonym: 9p monosomy
Synonym: 9p syndrome
Synonym: 9p- syndrome
Synonym: Alfi syndrome
Synonym: CHROMOSOME 9p DELETION SYNDROME
Synonym: Chromosome 9, monosomy 9p
Synonym: Chromosome 9p Deletion Syndrome
Synonym: MONOSOMY 9p SYNDROME
Tree Number: T10.5.9.8.17
database_cross_reference: CHV:0000048930
database_cross_reference: DO:DOID:0060732
database_cross_reference: JABL:148
database_cross_reference: MSH:C538024
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:158170

lethal restrictive dermopathy
type: Class
subclass of: skin disease
definition: A skin disease characterized by thin, tightly adherent translucent skin with erosions at flexure sites, superficial vessels, typical facial dysmorphism, and generalized joint ankylosis that has_material_basis_in heterozygous mutation in the LMNA gene on chromosome 1q22 or by homozygous or compound heterozygous mutation in the ZMPSTE24 gene on chromosome 1p34.
PMOID: PMO:00033957
Subclass_of: skin disease
Synonym: Congenital skin contracture
Synonym: FETAL HYPOKINESIA SEQUENCE DUE TO RESTRICTIVE DERMOPATHY
Synonym: Fetal hypokinesia sequence due to restrictive dermopathy
Synonym: HYPERKERATOSIS-CONTRACTURE SYNDROME
Synonym: Hyperkeratosis-contracture syndrome
Synonym: Infant restrictive dermopathy
Synonym: Infantile restrictive dermopathy
Synonym: Infantile restrictive dermopathy (disorder)
Synonym: Lethal tight skin contracture syndrome
Synonym: Lethal tight skin contracture syndrome (disorder)
Tree Number: T10.8.12.2.38
database_cross_reference: DO:DOID:0060762
database_cross_reference: MSH:C536920
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:150330
database_cross_reference: OMIM:275210
database_cross_reference: OMIM:606480
database_cross_reference: RCD:X50DY
database_cross_reference: SNOMEDCT_US:238873002
database_cross_reference: SNOMEDCT_US:400128006

autosomal recessive Robinow syndrome
type: Class
subclass of: Robinow syndrome
definition: A Robinow syndrome characterized by autosomal recessive inheritance of severe skeletal dysplasia characterized by dysmorphic facial features, including frontal bossing, hypertelorism, and broad nose, short-limbed dwarfism, vertebral segmentation, and genital hypoplasia that has_material_basis_in homozygous or compound heterozygous mutations in the ROR2 gene on chromosome 9q22.
PMOID: PMO:00025144
Subclass_of: Robinow syndrome
Synonym: COSTOVERTEBRAL SEGMENTATION DEFECT WITH MESOMELIA, FORMERLY
Synonym: COVESDEM SYNDROME, FORMERLY
Synonym: COVESDEM syndrome
Synonym: ROBINOW SYNDROME, AUTOSOMAL RECESSIVE
Synonym: RRS
Synonym: Robinow syndrome, autosomal recessive
Synonym: costovertebral segmentation defect-mesomelia syndrome
Tree Number: T10.1.26.4
database_cross_reference: DO:DOID:0060764
database_cross_reference: MSH:C535863
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:268310
database_cross_reference: OMIM:602337

autosomal dominant Robinow syndrome 2
type: Class
subclass of: Robinow syndrome
definition: A Robinow syndrome characterized by autosomal dominant inheritance of mesomelic limb shortening, genital hypoplasia, and distinctive facial features that has_material_basis_in heterozygous mutation in the DVL1 gene on chromosome 1p36.
PMOID: PMO:00025141
Subclass_of: Robinow syndrome
Synonym: DRS2
Synonym: ROBINOW SYNDROME, AUTOSOMAL DOMINANT 2
Tree Number: T10.1.26.1
database_cross_reference: DO:DOID:0060765
database_cross_reference: OMIM:601365
database_cross_reference: OMIM:616331

autosomal dominant Robinow syndrome 1
type: Class
subclass of: Robinow syndrome
definition: A Robinow syndrome characterized by autosomal dominant inheritance of dysmorphic features resembling a fetal face, mesomelic limb shortening, hypoplastic external genitalia in males, and renal and vertebral anomalies that has_material_basis_in heterozygous mutation in the WNT5A gene on chromosome 3p.
PMOID: PMO:00025143
Subclass_of: Robinow syndrome
Synonym: ACRAL DYSOSTOSIS WITH FACIAL AND GENITAL ABNORMALITIES
Synonym: Acral Dysostosis with Facial and Genital Abnormalities
Synonym: DRS1
Synonym: FETAL FACE SYNDROME
Synonym: Fetal Face Syndrome
Synonym: Fetal face syndrome
Synonym: Foetal face syndrome
Synonym: Mesomelic Dwarfism-Small Genitalia Syndrome
Synonym: ROBINOW DWARFISM
Synonym: ROBINOW SYNDROME, AUTOSOMAL DOMINANT 1
Tree Number: T10.1.26.3
database_cross_reference: CHV:0000025847
database_cross_reference: DO:DOID:0060254
database_cross_reference: DO:DOID:0060766
database_cross_reference: ICD10CM:Q87.1
database_cross_reference: JABL:562
database_cross_reference: MSH:C562492
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85048
database_cross_reference: OMIM:164975
database_cross_reference: OMIM:180700
database_cross_reference: RCD:PKy67
database_cross_reference: SNM:D-5043
database_cross_reference: SNMI:D4-00304
database_cross_reference: SNOMEDCT_US:76520005

autosomal dominant Robinow syndrome 3
type: Class
subclass of: Robinow syndrome
definition: A Robinow syndrome characterized by autosomal dominant inheritance of mesomelia, genital hypoplasia, and distinctive facial features comprising frontal bossing, prominent eyes, and a depressed nasal bridge that has_material_basis_in heterozygous mutation in the DVL3 gene on chromosome 3q27.
PMOID: PMO:00025142
Subclass_of: Robinow syndrome
Synonym: DRS3
Synonym: ROBINOW SYNDROME, AUTOSOMAL DOMINANT 3
Tree Number: T10.1.26.2
database_cross_reference: DO:DOID:0060767
database_cross_reference: OMIM:601368
database_cross_reference: OMIM:616894

Smith-Magenis syndrome
type: Class
subclass of: chromosomal deletion syndrome
definition: A chromosome deletion syndrome characterized by mild-to-moderate infantile hypotonia, minor skeletal anomalies, prepubertal short stature, brachydactyly, ophthalmologic and otolaryngologic abnormalities, peripheral neuropathy, developmental delay, cognitive impairment, and behavioral abnormalities that has_material basis_in a 3.7-Mb interstitial deletion in chromosome 17p11.2 or sometimes by mutations in the RAI1 gene in the same region.
PMOID: PMO:00028824
Subclass_of: chromosomal deletion syndrome
Synonym: 17p deletion syndrome
Synonym: 17p- syndrome
Synonym: 17p11.2 microdeletion syndrome
Synonym: CHROMOSOME 17p11.2 DELETION SYNDROME
Synonym: Chromosome 17p11.2 Deletion Syndrome
Synonym: SMITH-MAGENIS SYNDROME
Synonym: SMS
Synonym: Smith Magenis Syndrome
Synonym: Smith Magenis syndrome
Synonym: Smith-Magenis Syndrome
Tree Number: T10.5.9.8.47
database_cross_reference: CHV:0000048942
database_cross_reference: CSP:5002-0024
database_cross_reference: DO:DOID:0060768
database_cross_reference: ICD10CM:Q93.88
database_cross_reference: JABL:186
database_cross_reference: LCH_NW:sh2005007971
database_cross_reference: MEDCIN:312751
database_cross_reference: MSH:D058496
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:758.33
database_cross_reference: NCI:C75469
database_cross_reference: NDFRT:N0000182203
database_cross_reference: OMIM:182290
database_cross_reference: OMIM:607642
database_cross_reference: SNOMEDCT_US:401315004

congenital diarrhea
type: Class
subclass of: diarrhea
definition: A diarrhea characterized by frequent loose or liquid bowel movements where the disease is present from birth.
PMOID: PMO:00033750
Subclass_of: diarrhea
Tree Number: T10.8.11.14.5
database_cross_reference: DO:DOID:0060774

Norrie disease
type: Class
subclass of: X-linked disease
definition: A X-linked disease characterized by X-linked recessive inheritance of degenerative and proliferative changes of the neuroretina resulting in congenital blindness along with progressive mental disorders in about 50% of patients and sensorineural deafness in about 33% of patients that has_material_basis_in mutation in the NDP gene on chromosome Xp11.
PMOID: PMO:00028734
Subclass_of: X-linked disease
Synonym: ATROPHIA BULBORUM HEREDITARIA
Synonym: Anderson-Warburg Syndrome
Synonym: Atrophia bulborum hereditaria
Synonym: Atrophia bulborum hereditaria (disorder)
Synonym: Congenital Progressive Oculo-Acoustico-Cerebral Degeneration
Synonym: EPISKOPI BLINDNESS
Synonym: Episkopi blindness
Synonym: Fetal Iritis Syndrome
Synonym: ND
Synonym: NORRIE DISEASE
Tree Number: T10.5.3.4.14
database_cross_reference: CHV:0000026063
database_cross_reference: CSP:0977-5812
database_cross_reference: CSP:1114-9698
database_cross_reference: CSP:1840-2225
database_cross_reference: DO:DOID:0060844
database_cross_reference: JABL:489
database_cross_reference: MDR:10069760
database_cross_reference: MEDCIN:313592
database_cross_reference: MSH:C537849
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118634
database_cross_reference: OMIM:300658
database_cross_reference: OMIM:310600
database_cross_reference: RCD:X00dN
database_cross_reference: SNM:D-X256
database_cross_reference: SNMI:D4-A0020
database_cross_reference: SNOMEDCT_US:15228007

annular pancreas
type: Class
subclass of: pancreas disease
definition: A pancreas disease characterized by autosomal dominant inheritance of the annular pancreas (head of the pancreas forming a ring around the second portion of the duodenum) and duodenal stenosis.
PMOID: PMO:00033202
Subclass_of: pancreas disease
Synonym: Annular Pancreas
Synonym: Annular pancreas
Synonym: Annular pancreas (disorder)
Synonym: Anular pancreas
Synonym: PANCREAS, ANNULAR
Synonym: Pancreas, annular
Synonym: annular pancreas (diagnosis)
Synonym: anular pancreas
Synonym: pancreas annular
Tree Number: T10.8.8.4.6
database_cross_reference: CHV:0000016744
database_cross_reference: DO:DOID:0060850
database_cross_reference: DXP:U001392
database_cross_reference: HPO:HP:0001734
database_cross_reference: ICD10:Q45.1
database_cross_reference: ICD10AM:Q45.1
database_cross_reference: ICD10CM:Q45.1
database_cross_reference: MDR:10071757
database_cross_reference: MEDCIN:96032
database_cross_reference: MSH:C536376
database_cross_reference: MTHICD9:751.7
database_cross_reference: NCI:C98813
database_cross_reference: NCI_NICHD:C98813
database_cross_reference: OMIM:167750
database_cross_reference: OMIM:MTHU009578
database_cross_reference: RCD:PB74.
database_cross_reference: SNM:M-23410
database_cross_reference: SNMI:D4-58021
database_cross_reference: SNOMEDCT_US:40315008

Potocki-Lupski syndrome
type: Class
subclass of: chromosomal duplication syndrome
PMOID: PMO:00028769
Subclass_of: chromosomal duplication syndrome
Synonym: 17p11.2 Duplication Syndrome
Synonym: CHROMOSOME 17p11.2 DUPLICATION SYNDROME
Synonym: Chromosome 17p11.2 Duplication Syndrome
Synonym: Duplication 17p11.2 syndrome
Synonym: POTOCKI-LUPSKI SYNDROME
Synonym: PTLS
Synonym: Potocki-Lupski Syndrome
Synonym: Potocki-Lupski syndrome (dup(17)(p11.2p11.2))
Tree Number: T10.5.9.5.9
database_cross_reference: MSH:C538355
database_cross_reference: NCI:C124846
database_cross_reference: OMIM:610883

right atrial isomerism
type: Class
subclass of: visceral heterotaxy
definition: A visceral heterotaxy characterized by complete atrioventricular septal defect with a common atrium and univentricular AV connection, total anomalous pulmonary drainage, and transposition or malposition of the great arteries and may be associated with bilateral trilobed lungs, midline liver, asplenia and situs inversus affecting other organs that has_material_basis_in homozygous mutation in the GDF1 gene on chromosome 19p12.
PMOID: PMO:00028280
Subclass_of: visceral heterotaxy
Synonym: Asplenia with Cardiovascular Abnormalities
Synonym: Ivemark syndrome
Synonym: POLYASPLENIA
Synonym: Polyasplenia
Synonym: asplenia with cardiovascular anomalies
Tree Number: T10.4.18.1
database_cross_reference: DO:DOID:0060856
database_cross_reference: MSH:C566862
database_cross_reference: OMIM:208530

septooptic dysplasia
type: Class
subclass of: autosomal genetic disease
definition: An autosomal genetic disease characterized by the classical triad of optic nerve hypoplasia, pituitary gland hypoplasia and midline brain defects that has_material_basis_in mutation in the HESX1 gene on chromosome 3p14.
PMOID: PMO:00028501
Subclass_of: autosomal genetic disease
Synonym: DE MORSIER SYNDROME
Synonym: De Morsier Syndrome
Synonym: De Morsier syndrome
Synonym: Dysplasia, Septooptic
Synonym: Dysplasias, Septooptic
Synonym: SEPTOOPTIC DYSPLASIA
Synonym: SOD
Synonym: Septo Optic Dysplasia with Growth Hormone Deficiency
Synonym: Septo optic dysplasia
Synonym: Septo-Optic Dysplasia
Tree Number: T10.5.3.2.5
database_cross_reference: CHV:0000030465
database_cross_reference: DO:DOID:0060857
database_cross_reference: HPO:HP:0100842
database_cross_reference: ICD10:Q04.4
database_cross_reference: ICD10AM:Q04.4
database_cross_reference: MDR:10053146
database_cross_reference: MDR:10067159
database_cross_reference: MEDCIN:218977
database_cross_reference: MSH:D025962
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85063
database_cross_reference: NCI_NICHD:C85063
database_cross_reference: NDFRT:N0000011101
database_cross_reference: OMIM:182230
database_cross_reference: OMIM:601802
database_cross_reference: RCD:X008Y
database_cross_reference: SNMI:D4-01523
database_cross_reference: SNOMEDCT_US:204073006
database_cross_reference: SNOMEDCT_US:7611002

hypotonia-cystinuria syndrome
type: Class
subclass of: syndrome
definition: A syndrome that has_material_basis_in homozygous deletion on chromosome 2p21 that disrupts the SLC3A1 and PREPL genes. The deletion ranges in size from 23.8 to 75.5 kb. Itis characterized_by neonatal and infantile hypotonia and failure to thrive, cystinuria type 1 and nephrolithiasis, growth retardation due to growth hormone deficiency, and minor facial dysmorphism.
PMOID: PMO:00025177
Subclass_of: syndrome
Synonym: CYSTINURIA WITH MITOCHONDRIAL DISEASE
Synonym: Cystinuria with Mitochondrial Disease
Synonym: HOMOZYGOUS 2p16 DELETION SYNDROME, FORMERLY
Synonym: HOMOZYGOUS 2p21 DELETION SYNDROME
Synonym: HYPOTONIA-CYSTINURIA SYNDROME
Synonym: Homozygous 2p21 Deletion Syndrome
Synonym: Hypotonia cystinuria syndrome
Synonym: Hypotonia cystinuria syndrome (disorder)
Synonym: Hypotonia-Cystinuria Syndrome
Synonym: cystinuria with mitochondrial disease
Tree Number: T10.1.58
database_cross_reference: DO:DOID:0060858
database_cross_reference: MSH:C564710
database_cross_reference: OMIM:606407
database_cross_reference: SNOMEDCT_US:721173005

salmonellosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease caused by the bacteria of the genus Salmonella. It has sypmtoms diarrhea, fever, vomiting, and abdominal cramps 12 to 72 hours after infection. In most cases, the illness lasts four to seven days, and most people recover without treatment.
PMOID: PMO:00029527
Subclass_of: primary bacterial infectious disease
Synonym: INFECT SALMONELLA
Synonym: Infection, Salmonella
Synonym: Infections, Salmonella
Synonym: SALMONELLA
Synonym: SALMONELLA INFECT
Synonym: SALMONELLA INFECTION
Synonym: SALMONELLOSIS
Synonym: Salmonella
Synonym: Salmonella Infection
Synonym: Salmonella Infections
Tree Number: T10.7.3.1.22
database_cross_reference: AOD:0000004850
database_cross_reference: BI:BI00701
database_cross_reference: CCPSS:0020490
database_cross_reference: CCPSS:0037755
database_cross_reference: CHV:0000011020
database_cross_reference: COSTAR:U000601
database_cross_reference: CSP:0368-2732
database_cross_reference: DO:DOID:0060859
database_cross_reference: ICD10:A02.9
database_cross_reference: ICD10AM:A02.9
database_cross_reference: ICD10CM:A02.9
database_cross_reference: ICD9CM:003.9
database_cross_reference: ICPC2P:D70017
database_cross_reference: LCH_NW:sh2006006099
database_cross_reference: LNC:LA10503-3
database_cross_reference: MDR:10039430
database_cross_reference: MDR:10039436
database_cross_reference: MDR:10039437
database_cross_reference: MDR:10039438
database_cross_reference: MDR:10039447
database_cross_reference: MEDCIN:36182
database_cross_reference: MEDLINEPLUS:1213
database_cross_reference: MSH:D012480
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002666
database_cross_reference: RCD:A02z.
database_cross_reference: RCD:Ayu03
database_cross_reference: RCD:Xa8IA
database_cross_reference: RCDSY:Ayu03
database_cross_reference: SNM:D-0174
database_cross_reference: SNOMEDCT_US:105627003
database_cross_reference: SNOMEDCT_US:186094005
database_cross_reference: SNOMEDCT_US:186102000
database_cross_reference: SNOMEDCT_US:187270006
database_cross_reference: SNOMEDCT_US:302231008

hypoparathyroidism-deafness-renal disease syndrome
type: Class
subclass of: chromosomal deletion syndrome
definition: A characterized by autosomal dominant inheritance of hypoparathyroidism, sensorineural deafness and progressive renal failure that has material_basis_in chromosome deletion that results in haploinsufficiency of the GATA3 gene on chromosome 10p14.
PMOID: PMO:00028827
Subclass_of: chromosomal deletion syndrome
Synonym: BARAKAT SYNDROME
Synonym: Barakat syndrome
Synonym: HDR
Synonym: HDR syndrome
Synonym: HDRS
Synonym: HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE
Synonym: HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DYSPLASIA SYNDROME
Synonym: Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Synonym: NEPHROSIS, NERVE DEAFNESS, AND HYPOPARATHYROIDISM
Synonym: Nephrosis, nerve deafness, and hypoparathyroidism
Tree Number: T10.5.9.8.50
database_cross_reference: DO:DOID:0060878
database_cross_reference: MDR:10075281
database_cross_reference: MSH:C537907
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:131320
database_cross_reference: OMIM:146255

primary hypomagnesemia
type: Class
subclass of: metal metabolism disorder
definition: A hypomagnesemia characterized by autosomal recessive inheritance of excessive urinary Ca(2+) and Mg(2+) excretion that has material_basis_in homozygous or compound heterozygous mutation in the CLDN16 gene on chromosome 3q28.
PMOID: PMO:00029001
Subclass_of: metal metabolism disorder
Synonym: FHHNC without severe ocular involvement
Synonym: HOMG3
Synonym: HYPOMAGNESEMIA 3, RENAL
Synonym: HYPOMAGNESEMIA, FAMILIAL, WITH HYPERCALCIURIA AND NEPHROCALCINOSIS
Synonym: HYPOMAGNESEMIA, ISOLATED RENAL
Synonym: HYPOMAGNESEMIA, PRIMARY, DUE TO DEFECT IN RENAL TUBULAR TRANSPORT OF MAGNESIUM
Synonym: Hypomagnesemia 3, Renal
Synonym: Hypomagnesemia primary
Synonym: Hypomagnesemia, Primary, Due To Defect In Renal Tubular Transport Of Magnesium
Synonym: Hypomagnesemia, familial, with hypercalciuria and nephrocalcinosis
Tree Number: T10.6.2.4.1
database_cross_reference: DO:DOID:0060880
database_cross_reference: MSH:C537153
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:248250
database_cross_reference: OMIM:603959
database_cross_reference: RCD:X40RO
database_cross_reference: RCDAE:X40RO
database_cross_reference: SNMI:D6-98700
database_cross_reference: SNOMEDCT_US:80710001

ossification of the posterior longitudinal ligament of spine
type: Class
subclass of: connective tissue disease
definition: A connective tissue disease characterized by ectopic ossification of the posterior longitudinal spinal ligament resulting in spinal cord compression, myelopathy and hyperreflexia.
PMOID: PMO:00032299
Subclass_of: connective tissue disease
Synonym: OPLL
Synonym: OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT OF SPINE
Synonym: Ossification of the Posterior Longitudinal Ligament of Spine
Synonym: Ossification of the posterior longitudinal ligament of the spine
Tree Number: T10.8.4.1.15
database_cross_reference: DO:DOID:0060887
database_cross_reference: MSH:C537143
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:602475

prune belly syndrome
type: Class
subclass of: syndrome
definition: A syndrome that has material basis in homozygous mutation in the CHRM3 gene on chromosome 1q43. It is characterized by megacystis (massively enlarged bladder) with disorganized detrusor muscle, cryptorchidism, and thin abdominal musculature with overlying lax skin.
PMOID: PMO:00025174
Subclass_of: syndrome
Synonym: Congen prolapse bladder mucosa
Synonym: Congenital prolapse of bladder mucosa
Synonym: Congenital prolapse of bladder mucosa (disorder)
Synonym: Eagle-Barret syndrome
Synonym: Obrisnksy syndrome
Synonym: Prolapse of bladder mucosa
Synonym: abdominal muscle deficiency syndrome
Tree Number: T10.1.55
database_cross_reference: DO:DOID:0060889
database_cross_reference: ICD10CM:Q79.4
database_cross_reference: MTHICD9:753.8
database_cross_reference: MTHICD9:756.71
database_cross_reference: RCD:PDy7.
database_cross_reference: SNOMEDCT_US:205023004

Norman-Roberts syndrome
type: Class
subclass of: lissencephaly
definition: A lissencephaly that has_material_basis_in homozygous mutation in the gene encoding reelin (RELN) on chromosome 7q22.
PMOID: PMO:00028242
Subclass_of: lissencephaly
Synonym: LIS2
Synonym: LISSENCEPHALY 2
Synonym: LISSENCEPHALY SYNDROME, NORMAN-ROBERTS TYPE
Synonym: Lissencephaly 2
Synonym: Lissencephaly syndrome Norman Roberts type
Synonym: Lissencephaly syndrome Norman Roberts type (disorder)
Synonym: Lissencephaly syndrome, Norman-Roberts type
Synonym: Microlissencephaly type A
Synonym: NORMAN-ROBERTS SYNDROME
Synonym: Norman Roberts lissencephaly syndrome
Tree Number: T10.4.1.4.1
database_cross_reference: DO:DOID:0060902
database_cross_reference: JABL:488
database_cross_reference: MSH:C537848
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:257320
database_cross_reference: OMIM:600514
database_cross_reference: SNOMEDCT_US:717977003

thrombosis
type: Class
subclass of: vascular disease
definition: A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
PMOID: PMO:00031973
Subclass_of: vascular disease
Synonym: Blood vessel thrombosis
Synonym: THROMBOSIS
Synonym: Thrombosed
Synonym: Thromboses
Synonym: Thrombosis
Synonym: Thrombosis (disorder)
Synonym: Thrombosis (qualifier value)
Synonym: Thrombosis NOS
Synonym: Thrombosis [Disease/Finding]
Synonym: Thrombosis, NOS
Tree Number: T10.8.3.3.8
database_cross_reference: AOD:0000005938
database_cross_reference: CCPSS:0019080
database_cross_reference: CHV:0000012227
database_cross_reference: CHV:0000058002
database_cross_reference: CSP:0571-8378
database_cross_reference: CST:THROM
database_cross_reference: DO:DOID:0060903
database_cross_reference: DXP:U004006
database_cross_reference: LCH:U004672
database_cross_reference: LCH_NW:sh85135077
database_cross_reference: LNC:LP31622-1
database_cross_reference: MDR:10043607
database_cross_reference: MDR:10043628
database_cross_reference: MSH:D013927
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:453.9
database_cross_reference: NCI:C26891
database_cross_reference: NCI_FDA:2100
database_cross_reference: NCI_NICHD:C26891
database_cross_reference: NDFRT:N0000002936
database_cross_reference: OMIM:MTHU005312
database_cross_reference: PSY:53040
database_cross_reference: RCD:XC0fW
database_cross_reference: SNM:M-35100
database_cross_reference: SNMI:M-35100
database_cross_reference: SNOMEDCT_US:118927008
database_cross_reference: SNOMEDCT_US:264579008
database_cross_reference: SNOMEDCT_US:439127006
database_cross_reference: SNOMEDCT_US:70281000

blastoma
type: Class
subclass of: cell type cancer
definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from precursor cells called blast cells.
PMOID: PMO:00025422
Subclass_of: cell type cancer
Synonym: Blastoma
Synonym: Blastoma, NOS
Synonym: Embryoma
Synonym: embryoma
Tree Number: T10.2.1.1.10
database_cross_reference: DO:DOID:0070003
database_cross_reference: DO:DOID:4766
database_cross_reference: NCI:C8997
database_cross_reference: NCI_NCI-GLOSS:CDR0000367443
database_cross_reference: RCD:BB02.
database_cross_reference: SNMI:M-80003
database_cross_reference: SNOMEDCT_US:86049000

Meckel syndrome 1
type: Class
subclass of: Meckel syndrome
definition: A Meckel syndrome that has_material_basis_in an autosomal recessive mutation of MKS1 on chromosome 17q22.
PMOID: PMO:00028325
Subclass_of: Meckel syndrome
Synonym: DYSENCEPHALIA SPLANCHNOCYSTICA
Synonym: Dysencephalia Splanchnocystica
Synonym: Dysencephalia splachnocystica
Synonym: GRUBER SYNDROME
Synonym: Gruber syndrome
Synonym: MECKEL SYNDROME
Synonym: MECKEL SYNDROME, TYPE 1
Synonym: MECKEL-GRUBER SYNDROME
Synonym: MECKEL-GRUBER SYNDROME, TYPE 1
Synonym: MES
Tree Number: T10.5.1.2.1
database_cross_reference: DO:DOID:0070115
database_cross_reference: MEDCIN:358438
database_cross_reference: MSH:C536133
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:249000
database_cross_reference: OMIM:609883

Meckel syndrome 2
type: Class
subclass of: Meckel syndrome
definition: A Meckel syndrome that has_material_basis_in an autosomal recessive mutation of TMEM216 on chromosome 11q12.2.
PMOID: PMO:00028327
Subclass_of: Meckel syndrome
Synonym: MECKEL SYNDROME, TYPE 2
Synonym: MECKEL-GRUBER SYNDROME, TYPE 2
Synonym: MKS2
Synonym: Meckel Syndrome, Type 2
Synonym: Meckel syndrome type 2
Synonym: Meckel syndrome type 2 (diagnosis)
Synonym: Meckel-Gruber Syndrome, Type 2
Synonym: Meckel-Gruber syndrome, type 2
Tree Number: T10.5.1.2.3
database_cross_reference: DO:DOID:0070116
database_cross_reference: MEDCIN:358439
database_cross_reference: MSH:C536131
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:603194
database_cross_reference: OMIM:613277

Meckel syndrome 3
type: Class
subclass of: Meckel syndrome
definition: A Meckel syndrome that has_material_basis_in an autosomal recessive mutation of TMEM67 on chromosome 8q22.1.
PMOID: PMO:00028326
Subclass_of: Meckel syndrome
Synonym: MECKEL SYNDROME, TYPE 3
Synonym: MECKEL-GRUBER SYNDROME, TYPE 3
Synonym: MKS3
Synonym: Meckel Syndrome, Type 3
Synonym: Meckel syndrome type 3
Synonym: Meckel syndrome type 3 (diagnosis)
Synonym: Meckel-Gruber Syndrome, Type 3
Synonym: Meckel-Gruber syndrome, type 3
Tree Number: T10.5.1.2.2
database_cross_reference: DO:DOID:0070117
database_cross_reference: MEDCIN:358440
database_cross_reference: MSH:C536132
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:607361
database_cross_reference: OMIM:609884

Meckel syndrome 4
type: Class
subclass of: Meckel syndrome
definition: A Meckel syndrome that has_material_basis_in an autosomal recessive mutation of CEP290 on chromosome 12q21.32.
PMOID: PMO:00028329
Subclass_of: Meckel syndrome
Synonym: MECKEL SYNDROME, TYPE 4
Synonym: MECKEL-GRUBER SYNDROME, TYPE 4
Synonym: MKS4
Synonym: Meckel Syndrome, Type 4
Synonym: Meckel syndrome type 4
Synonym: Meckel syndrome type 4 (diagnosis)
Synonym: Meckel-Gruber Syndrome, Type 4
Synonym: Meckel-Gruber syndrome, type 4
Tree Number: T10.5.1.2.5
database_cross_reference: DO:DOID:0070118
database_cross_reference: MEDCIN:358441
database_cross_reference: MSH:C567003
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:610142
database_cross_reference: OMIM:611134

Meckel syndrome 5
type: Class
subclass of: Meckel syndrome
definition: A Meckel syndrome that has_material_basis_in an autosomal recessive mutation of RPGRIP1L on chromosome 16q12.2.
PMOID: PMO:00028328
Subclass_of: Meckel syndrome
Synonym: MECKEL SYNDROME, TYPE 5
Synonym: MKS5
Synonym: Meckel Syndrome, Type 5
Synonym: Meckel syndrome type 5
Synonym: Meckel syndrome type 5 (diagnosis)
Synonym: Meckel-Gruber syndrome, type 5
Tree Number: T10.5.1.2.4
database_cross_reference: DO:DOID:0070119
database_cross_reference: MEDCIN:358442
database_cross_reference: MSH:C566915
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:610937
database_cross_reference: OMIM:611561

Meckel syndrome 6
type: Class
subclass of: Meckel syndrome
definition: A Meckel syndrome that has_material_basis_in an autosomal recessive mutation of CC2D2A on chromosome 4p15.32.
PMOID: PMO:00028331
Subclass_of: Meckel syndrome
Synonym: MECKEL SYNDROME, TYPE 6
Synonym: MECKEL SYNDROME, TYPE 6 (disorder)
Synonym: MKS6
Synonym: Meckel Syndrome, Type 6
Synonym: Meckel syndrome type 6
Synonym: Meckel syndrome type 6 (diagnosis)
Synonym: Meckel-Gruber syndrome, type 6
Tree Number: T10.5.1.2.7
database_cross_reference: DO:DOID:0070120
database_cross_reference: MEDCIN:358443
database_cross_reference: MSH:C567365
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:612013
database_cross_reference: OMIM:612284

Meckel syndrome 7
type: Class
subclass of: Meckel syndrome
definition: A Meckel syndrome that has_material_basis_in an autosomal recessive mutation of NPHP3 on chromosome 3q22.1.
PMOID: PMO:00028330
Subclass_of: Meckel syndrome
Synonym: GOLDSTON SYNDROME
Synonym: Goldston syndrome
Synonym: MECKEL SYNDROME, TYPE 7
Synonym: MKS7
Synonym: Meckel like syndrome
Synonym: Meckel syndrome type 7
Synonym: Meckel syndrome type 7 (diagnosis)
Synonym: Meckel-Gruber syndrome, type 7
Synonym: Meckel-Like Syndrome
Synonym: RENAL-HEPATIC-PANCREATIC DYSPLASIA WITH DANDY-WALKER CYST
Tree Number: T10.5.1.2.6
database_cross_reference: DO:DOID:0070121
database_cross_reference: MEDCIN:358444
database_cross_reference: MSH:C537756
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:267010
database_cross_reference: OMIM:608002

Meckel syndrome 8
type: Class
subclass of: Meckel syndrome
definition: A Meckel syndrome that has_material_basis_in an autosomal recessive mutation of TCTN2 on chromosome 12q24.31.
PMOID: PMO:00028332
Subclass_of: Meckel syndrome
Synonym: MECKEL SYNDROME, TYPE 8
Synonym: MKS8
Synonym: Meckel syndrome type 8
Synonym: Meckel syndrome type 8 (diagnosis)
Synonym: Meckel-Gruber syndrome, type 8
Tree Number: T10.5.1.2.8
database_cross_reference: DO:DOID:0070122
database_cross_reference: MEDCIN:358445
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:613885

muscular disease
type: Class
subclass of: musculoskeletal system disease
definition: A muscular disease in which the muscle fibers do not function resulting in muscular weakness.
PMOID: PMO:00032321
Subclass_of: musculoskeletal system disease
Synonym: A-51 MYOPATHIES
Synonym: DISORDER MUSCLE
Synonym: Disorder muscle
Synonym: Disorder of muscle
Synonym: Disorder of muscle (disorder)
Synonym: Disorder of muscle -RETIRED-
Synonym: Disorder of muscle, NOS
Synonym: Disorder of muscle, unspec
Synonym: Disorder of muscle, unspecified
Synonym: Disorder of skeletal AND/OR smooth muscle
Tree Number: T10.8.4.3
database_cross_reference: AOD:0000005063
database_cross_reference: AOD:0000005066
database_cross_reference: BI:BI00507
database_cross_reference: CCPSS:0045912
database_cross_reference: CCPSS:1018022
database_cross_reference: CHV:0000008361
database_cross_reference: COSTAR:U000457
database_cross_reference: CSP:1982-9451
database_cross_reference: CST:MS/MUS
database_cross_reference: CST:MYOPATHY
database_cross_reference: DO:DOID:0080000
database_cross_reference: DO:DOID:423
database_cross_reference: DO:DOID:66
database_cross_reference: DXP:U002703
database_cross_reference: HPO:HP:0003198
database_cross_reference: ICD10:G72.9
database_cross_reference: ICD10:M60-M63.9
database_cross_reference: ICD10:M62.9
database_cross_reference: ICD10AM:G72.9
database_cross_reference: ICD10AM:M60-M63.9
database_cross_reference: ICD10AM:M62.9
database_cross_reference: ICD10CM:G72.9
database_cross_reference: ICD10CM:M60-M63
database_cross_reference: ICD10CM:M62.9
database_cross_reference: ICD9CM:359.9
database_cross_reference: ICPC2P:L99023
database_cross_reference: LCH_NW:sh85088688
database_cross_reference: MDR:10013237
database_cross_reference: MDR:10028300
database_cross_reference: MDR:10028301
database_cross_reference: MDR:10028302
database_cross_reference: MDR:10028640
database_cross_reference: MDR:10028641
database_cross_reference: MDR:10028649
database_cross_reference: MEDCIN:319450
database_cross_reference: MEDCIN:91077
database_cross_reference: MEDLINEPLUS:510
database_cross_reference: MSH:D009135
database_cross_reference: MTH:503
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101216
database_cross_reference: NCI_NICHD:C101216
database_cross_reference: NDFRT:N0000002064
database_cross_reference: OMIM:590030
database_cross_reference: OMIM:590075
database_cross_reference: OMIM:MTHU003653
database_cross_reference: OMIM:MTHU049021
database_cross_reference: PSY:32600
database_cross_reference: RCD:Nyu8B
database_cross_reference: RCD:X708D
database_cross_reference: RCD:X708s
database_cross_reference: RCDSY:Nyu8B
database_cross_reference: SNM:D-8004
database_cross_reference: SNM:D-8060
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D1-50010
database_cross_reference: SNMI:DA-51000
database_cross_reference: SNOMEDCT_US:129565002
database_cross_reference: SNOMEDCT_US:155094005
database_cross_reference: SNOMEDCT_US:155099000
database_cross_reference: SNOMEDCT_US:203833006
database_cross_reference: SNOMEDCT_US:203845002
database_cross_reference: SNOMEDCT_US:267711006
database_cross_reference: SNOMEDCT_US:267714003

bone disease
type: Class
subclass of: connective tissue disease
definition: A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function.
PMOID: PMO:00032030
Subclass_of: connective tissue disease
Synonym: BONE DIS
Synonym: BONE DISORDER
Synonym: BONE DISORDER (NOS)
Synonym: Bone Disease
Synonym: Bone Diseases
Synonym: Bone Diseases [Disease/Finding]
Synonym: Bone Disorders
Synonym: Bone disease
Synonym: Bone disease, NOS
Synonym: Bone disorder
Tree Number: T10.8.4.1.5
database_cross_reference: CHV:0000002066
database_cross_reference: CSP:2715-1521
database_cross_reference: CST:BONE DIS
database_cross_reference: CST:MS/BON
database_cross_reference: DO:DOID:0080001
database_cross_reference: ICD10:M89.9
database_cross_reference: ICD10AM:M89.9
database_cross_reference: ICD10CM:M89.9
database_cross_reference: ICPC2P:L99097
database_cross_reference: LCH_NW:sh85015545
database_cross_reference: MDR:10005956
database_cross_reference: MDR:10005957
database_cross_reference: MDR:10005958
database_cross_reference: MDR:10013194
database_cross_reference: MDR:10031268
database_cross_reference: MEDCIN:330558
database_cross_reference: MEDLINEPLUS:170
database_cross_reference: MSH:D001847
database_cross_reference: MTH:503
database_cross_reference: MTH:536
database_cross_reference: MTH:U001752
database_cross_reference: NDFRT:N0000000584
database_cross_reference: PSY:06540
database_cross_reference: RCD:XM0um
database_cross_reference: RCD:XaBMS
database_cross_reference: SNM:D-3400
database_cross_reference: SNM:U000007
database_cross_reference: SNMI:D1-60000
database_cross_reference: SNOMEDCT_US:156814002
database_cross_reference: SNOMEDCT_US:203524000
database_cross_reference: SNOMEDCT_US:268126004
database_cross_reference: SNOMEDCT_US:274145000
database_cross_reference: SNOMEDCT_US:308147009
database_cross_reference: SNOMEDCT_US:76069003
database_cross_reference: SNOMEDCT_VET:76069003

chromosomal disease
type: Class
subclass of: genetic disease
definition: A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes.
PMOID: PMO:00028755
Subclass_of: genetic disease
Synonym: 4-02 CHROMOSOMAL DISEASES
Synonym: Abnormal;chromosome(s)
Synonym: Abnormalities, Chromosomal
Synonym: Abnormalities, Chromosome
Synonym: Anomaly of chromosome
Synonym: Anomaly of chromosome, NOS
Synonym: CHROMOSOMAL DIS
Synonym: CHROMOSOMAL DISEASES
Synonym: CHROMOSOME ABNORM DIS
Synonym: CHROMOSOME ABNORMALITY
Tree Number: T10.5.9
database_cross_reference: CHV:0000002941
database_cross_reference: CSP:1254-7954
database_cross_reference: CST:CHROMOSOME ABNORM
database_cross_reference: DO:DOID:0080014
database_cross_reference: DO:DOID:1086
database_cross_reference: ICD10:Q99.9
database_cross_reference: ICD10AM:Q99.9
database_cross_reference: ICD10CM:Q99.9
database_cross_reference: ICD9CM:758
database_cross_reference: ICD9CM:758.9
database_cross_reference: ICPC2P:A90002
database_cross_reference: MDR:10008810
database_cross_reference: MDR:10008814
database_cross_reference: MDR:10008815
database_cross_reference: MDR:10008824
database_cross_reference: MDR:10010270
database_cross_reference: MDR:10067477
database_cross_reference: MEDCIN:211342
database_cross_reference: MSH:D025063
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34470
database_cross_reference: NDFRT:N0000000783
database_cross_reference: NDFRT:N0000000784
database_cross_reference: PSY:09160
database_cross_reference: RCD:PJ...
database_cross_reference: RCD:PJz..
database_cross_reference: RCD:PJzz.
database_cross_reference: SNM:D-5500
database_cross_reference: SNM:NOCODE
database_cross_reference: SNM:U000360
database_cross_reference: SNMI:D4-02000
database_cross_reference: SNOMEDCT_US:157018005
database_cross_reference: SNOMEDCT_US:157023005
database_cross_reference: SNOMEDCT_US:205724000
database_cross_reference: SNOMEDCT_US:205729005
database_cross_reference: SNOMEDCT_US:409709004
database_cross_reference: SNOMEDCT_US:74345006

physical disorder
type: Class
subclass of: Disease
definition: A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.
PMOID: PMO:00028236
Subclass_of: Disease
Synonym: Illness (Physical)
Synonym: Physical Disorders
Synonym: Physical Illness
Synonym: disorder physical
Synonym: disorders physical
Synonym: illness physical
Synonym: physical disorders
Synonym: physical illness
Tree Number: T10.4
database_cross_reference: AOD:0000022733
database_cross_reference: CHV:0000043763
database_cross_reference: DO:DOID:0080015
database_cross_reference: MTH:NOCODE
database_cross_reference: PSY:24410
database_cross_reference: PSY:38493
database_cross_reference: PSY:38555

spina bifida
type: Class
subclass of: neural tube defect
PMOID: PMO:00028272
Subclass_of: neural tube defect
Synonym: Bifida, Spina
Synonym: Cleft Spine
Synonym: Cleft spine
Synonym: Defective spinal closure
Synonym: Dysraphia, Spinal
Synonym: Dysraphias, Spinal
Synonym: Dysraphism, Spinal
Synonym: Dysraphisms, Spinal
Synonym: Open Spine
Synonym: Open spine
Tree Number: T10.4.16.2
database_cross_reference: AOD:0000004989
database_cross_reference: CCPSS:0027722
database_cross_reference: CCPSS:0037001
database_cross_reference: CHV:0000015308
database_cross_reference: CSP:0724-6476
database_cross_reference: CST:SPINA BIFIDA
database_cross_reference: DO:DOID:0080016
database_cross_reference: DO:DOID:1089
database_cross_reference: DXP:U003773
database_cross_reference: HPO:HP:0002414
database_cross_reference: ICD10:Q05
database_cross_reference: ICD10:Q05.9
database_cross_reference: ICD10AM:Q05
database_cross_reference: ICD10AM:Q05.9
database_cross_reference: ICD10CM:Q05
database_cross_reference: ICD10CM:Q05.9
database_cross_reference: ICD9CM:741
database_cross_reference: ICPC2P:N85002
database_cross_reference: LCH_NW:sh85126658
database_cross_reference: MDR:10041524
database_cross_reference: MEDCIN:32604
database_cross_reference: MEDLINEPLUS:1319
database_cross_reference: MSH:D016135
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101214
database_cross_reference: NCI_CDISC:C101214
database_cross_reference: NCI_NICHD:C101214
database_cross_reference: NDFRT:N0000003373
database_cross_reference: OMIM:182940
database_cross_reference: OMIM:MTHU007928
database_cross_reference: OMIM:MTHU015110
database_cross_reference: PSY:49245
database_cross_reference: RCD:P1...
database_cross_reference: RCD:P1z..
database_cross_reference: SNM:M-21510
database_cross_reference: SNMI:D4-95100
database_cross_reference: SNOMEDCT_US:156888006
database_cross_reference: SNOMEDCT_US:204017003
database_cross_reference: SNOMEDCT_US:67531005
database_cross_reference: SNOMEDCT_VET:67531005

fibrogenesis imperfecta ossium
type: Class
subclass of: syndrome
definition: A syndrome that involves abnormality of collagen synthesis in lamellar bones, with manifestations limited to the skeleton. The initial symptom is frequently spontaneous fractures.
PMOID: PMO:00025218
Subclass_of: syndrome
Synonym: Baker's disease
Tree Number: T10.1.86
database_cross_reference: DO:DOID:0080040

inclusion-cell disease
type: Class
subclass of: lysosomal storage disease
PMOID: PMO:00029049
Subclass_of: lysosomal storage disease
Synonym: Deficiency of N-acetylglucosamine-1-phosphotransferase
Synonym: I CELL DIS
Synonym: I Cell Disease
Synonym: I cell disease
Synonym: I-CELL DISEASE
Synonym: I-Cell Disease
Synonym: I-Cell Diseases
Synonym: I-cell - Inclusion cell disease
Synonym: I-cell disease
Synonym: I-cell disease (diagnosis)
Tree Number: T10.6.2.8.2
database_cross_reference: CHV:0000006516
database_cross_reference: CSP:1849-6277
database_cross_reference: DO:DOID:0080070
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001206
database_cross_reference: HPO:HP:0003264
database_cross_reference: MDR:10072928
database_cross_reference: MEDCIN:273576
database_cross_reference: MSH:D009081
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:272.7
database_cross_reference: NCI:C61270
database_cross_reference: OMIM:252500
database_cross_reference: OMIM:MTHU011301
database_cross_reference: RCD:X40W9
database_cross_reference: RCD:X40WA
database_cross_reference: SNM:D-1464
database_cross_reference: SNMI:D6-72200
database_cross_reference: SNOMEDCT_US:238046002
database_cross_reference: SNOMEDCT_US:70199000

pseudo-Hurler polydystrophy
type: Class
subclass of: lysosomal storage disease
PMOID: PMO:00029112
Subclass_of: lysosomal storage disease
Synonym: ML III
Synonym: ML III ALPHA/BETA
Synonym: ML IIIA
Synonym: MUCOLIPIDOSIS III
Synonym: MUCOLIPIDOSIS III ALPHA/BETA
Synonym: MUCOLIPIDOSIS IIIA
Synonym: Mucolipidoses, Type III
Synonym: Mucolipidosis III
Synonym: Mucolipidosis III Alpha Beta
Synonym: Mucolipidosis IIIa
Tree Number: T10.6.2.8.9
database_cross_reference: CHV:0000010280
database_cross_reference: DO:DOID:0080071
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001207
database_cross_reference: MDR:10072929
database_cross_reference: MSH:D009081
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:252600
database_cross_reference: OMIM:607840
database_cross_reference: RCD:X40WB
database_cross_reference: SNM:D-1465
database_cross_reference: SNMI:D6-72220
database_cross_reference: SNOMEDCT_US:190792005
database_cross_reference: SNOMEDCT_US:190949005
database_cross_reference: SNOMEDCT_US:65764006

spina bifida occulta
type: Class
subclass of: spina bifida
PMOID: PMO:00028275
Subclass_of: spina bifida
Synonym: Bifida, spina - occulta
Synonym: Closed Spinal Bifida
Synonym: Closed spina bifida
Synonym: Cryptomerorachischisis
Synonym: Occult Spina Bifida
Synonym: Occulta - spina bifida
Synonym: SBO - Spina bifida occulta
Synonym: SPINA BIFIDA OCCULTA
Synonym: Spina Bifida Occulta
Synonym: Spina Bifida Occulta [Disease/Finding]
Tree Number: T10.4.16.2.3
database_cross_reference: CCPSS:0036998
database_cross_reference: CHV:0000015306
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:SPINA BIFIDA
database_cross_reference: DO:DOID:0080073
database_cross_reference: HPO:HP:0003298
database_cross_reference: ICD10:Q76.0
database_cross_reference: ICD10AM:Q76.0
database_cross_reference: ICD10CM:Q76.0
database_cross_reference: ICD9CM:756.17
database_cross_reference: MDR:10009650
database_cross_reference: MDR:10041525
database_cross_reference: MEDCIN:211322
database_cross_reference: MSH:D016136
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101044
database_cross_reference: NCI_NICHD:C101044
database_cross_reference: NDFRT:N0000003374
database_cross_reference: OMIM:MTHU036568
database_cross_reference: RCD:PG17.
database_cross_reference: SNM:M-21510
database_cross_reference: SNM:M-21580
database_cross_reference: SNMI:D4-15046
database_cross_reference: SNOMEDCT_US:157003009
database_cross_reference: SNOMEDCT_US:268349005
database_cross_reference: SNOMEDCT_US:76916001

neural tube defect
type: Class
subclass of: physical disorder
PMOID: PMO:00028270
Subclass_of: physical disorder
Synonym: Abnormality of neural tube closure
Synonym: Defect, Neural Tube
Synonym: Defects, Neural Tube
Synonym: Developmental Defects, Neural Tube
Synonym: Developmental Neural Tube Defects
Synonym: Incomplete closure of the vertebral arch
Synonym: NEURAL TUBE DEFECT
Synonym: NTD
Synonym: NTD - Neural tube defect
Synonym: NTDS
Tree Number: T10.4.16
database_cross_reference: CCPSS:0037394
database_cross_reference: CHV:0000008617
database_cross_reference: CSP:0725-4145
database_cross_reference: CSP:2403-8856
database_cross_reference: HPO:HP:0010301
database_cross_reference: HPO:HP:0045005
database_cross_reference: LNC:LP173544-0
database_cross_reference: LNC:LP62866-6
database_cross_reference: LNC:MTHU052259
database_cross_reference: MDR:10052046
database_cross_reference: MEDCIN:360187
database_cross_reference: MEDLINEPLUS:340
database_cross_reference: MSH:D009436
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84923
database_cross_reference: NCI_NICHD:C84923
database_cross_reference: NDFRT:N0000002161
database_cross_reference: OMIM:MTHU048953
database_cross_reference: RCD:X77q9
database_cross_reference: SNOMEDCT_US:253098009

nonsyndromic congenital nail disorder 1
type: Class
subclass of: nail disease
PMOID: PMO:00033760
Subclass_of: nail disease
Synonym: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 1
Synonym: NDNC1
Synonym: ONYCHODYSTROPHY TOTALIS, ISOLATED
Synonym: Onychodystrophy Totalis, Isolated
Synonym: TWENTY-NAIL DYSTROPHY
Synonym: Trachonychia
Synonym: Twenty nail dystrophy
Synonym: Twenty nail dystrophy (disorder)
Synonym: Twenty-Nail Dystrophy
Synonym: trachonychia
Tree Number: T10.8.12.1.2
database_cross_reference: CHV:0000032665
database_cross_reference: DO:DOID:0080079
database_cross_reference: MEDCIN:37100
database_cross_reference: MSH:C562907
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:161050
database_cross_reference: RCD:X5099
database_cross_reference: SNOMEDCT_US:238719003

nonsyndromic congenital nail disorder 2
type: Class
subclass of: nail disease
PMOID: PMO:00033759
Subclass_of: nail disease
Synonym: KOILONYCHIA WITH LEUKONYCHIA
Tree Number: T10.8.12.1.1
database_cross_reference: DO:DOID:0080080
database_cross_reference: OMIM:149300

nonsyndromic congenital nail disorder 3
type: Class
subclass of: nail disease
PMOID: PMO:00033762
Subclass_of: nail disease
Synonym: LEUKONYCHIA STRIATUS
Tree Number: T10.8.12.1.4
database_cross_reference: DO:DOID:0080081
database_cross_reference: OMIM:151600

nonsyndromic congenital nail disorder 4
type: Class
subclass of: nail disease
PMOID: PMO:00033761
Subclass_of: nail disease
Synonym: ANONYCHIA TOTALIS
Synonym: ANONYCHIA/HYPONYCHIA CONGENITA
Synonym: HYPONYCHIA CONGENITA
Synonym: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 4
Synonym: NDNC4
Synonym: anonychia congenita
Tree Number: T10.8.12.1.3
database_cross_reference: DO:DOID:0050643
database_cross_reference: DO:DOID:0080082
database_cross_reference: OMIM:206800
database_cross_reference: OMIM:610573

nonsyndromic congenital nail disorder 5
type: Class
subclass of: nail disease
PMOID: PMO:00033764
Subclass_of: nail disease
Synonym: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 5
Synonym: NDNC5
Synonym: ONYCHOLYSIS, HEREDITARY DISTAL
Synonym: ONYCHOLYSIS, PARTIAL, WITH SCLERONYCHIA
Synonym: Onycholysis, Partial, with Scleronychia
Tree Number: T10.8.12.1.6
database_cross_reference: DO:DOID:0080083
database_cross_reference: MSH:C563503
database_cross_reference: OMIM:164800

nonsyndromic congenital nail disorder 6
type: Class
subclass of: nail disease
PMOID: PMO:00033763
Subclass_of: nail disease
Synonym: ANONYCHIA, PARTIAL
Synonym: ANONYCHIA/HYPONYCHIA AND ONYCHODYSTROPHY
Synonym: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 6
Synonym: NDNC6
Tree Number: T10.8.12.1.5
database_cross_reference: DO:DOID:0080084
database_cross_reference: OMIM:107000

nonsyndromic congenital nail disorder 7
type: Class
subclass of: nail disease
PMOID: PMO:00033766
Subclass_of: nail disease
Synonym: Congenital Isolated nail dysplasia
Synonym: Isolated congenital nail dysplasia
Synonym: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 7
Synonym: NDNC7
Synonym: Nail dysplasia, isolated congenital
Synonym: ONYCHODYSPLASIA, ISOLATED CONGENITAL
Synonym: Onychodysplasia, Isolated Congenital
Tree Number: T10.8.12.1.8
database_cross_reference: DO:DOID:0080085
database_cross_reference: MSH:C538333
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:605779

nonsyndromic congenital nail disorder 8
type: Class
subclass of: nail disease
PMOID: PMO:00033765
Subclass_of: nail disease
Synonym: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 8
Synonym: NDNC8
Synonym: TOENAIL DYSTROPHY, ISOLATED
Synonym: Toenail Dystrophy, Isolated
Tree Number: T10.8.12.1.7
database_cross_reference: DO:DOID:0080086
database_cross_reference: MSH:C564384
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:120120
database_cross_reference: OMIM:607523

nonsyndromic congenital nail disorder 9
type: Class
subclass of: nail disease
PMOID: PMO:00033767
Subclass_of: nail disease
Synonym: ANONYCHIA-ONYCHOLYSIS, ISOLATED
Synonym: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
Synonym: NAIL DYSPLASIA
Synonym: NDNC9
Synonym: ONYCHODYSTROPHY
Tree Number: T10.8.12.1.9
database_cross_reference: DO:DOID:0080087
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:614149

nonsyndromic congenital nail disorder 10
type: Class
subclass of: nail disease
PMOID: PMO:00033769
Subclass_of: nail disease
Synonym: CLAW-SHAPED NAILS
Synonym: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 10
Synonym: NDNC10
Synonym: ONYCHAUXIS, HYPONYCHIA, AND ONYCHOLYSIS
Tree Number: T10.8.12.1.11
database_cross_reference: DO:DOID:0080088
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:603409
database_cross_reference: OMIM:614157

microcephaly and chorioretinopathy 1
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by delayed psychomotor development and visual impairment, often accompanied by short stature and has_material_basis_in homozygous or compound heterozygous mutation in the TUBGCP6 gene.
PMOID: PMO:00025132
Subclass_of: syndrome
Synonym: MCCRP1
Synonym: MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 1
Synonym: Microcephaly and Chorioretinopathy, Autosomal Recessive, Type 1
Tree Number: T10.1.17
database_cross_reference: DO:DOID:0080105
database_cross_reference: NCI:C129306
database_cross_reference: OMIM:251270
database_cross_reference: OMIM:610053

microcephaly and chorioretinopathy 2
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by delayed psychomotor development, visual impairment, and short stature and has_material_basis_in homozygous mutation in the PLK4 gene.
PMOID: PMO:00025130
Subclass_of: syndrome
Synonym: MCCRP2
Synonym: MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 2
Tree Number: T10.1.15
database_cross_reference: DO:DOID:0080106
database_cross_reference: OMIM:605031
database_cross_reference: OMIM:616171

microcephaly and chorioretinopathy 3
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by congenital microcephaly and chorioretinal dysplasia associated with poor vision and nystagmus and has_material_basis_in compound heterozygous mutation in the TUBGCP4 gene.
PMOID: PMO:00025131
Subclass_of: syndrome
Synonym: MCCRP3
Synonym: MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 3
Tree Number: T10.1.16
database_cross_reference: DO:DOID:0080107
database_cross_reference: OMIM:609610
database_cross_reference: OMIM:616335

multiple pterygium syndrome
type: Class
subclass of: genetic disease
PMOID: PMO:00028753
Subclass_of: genetic disease
Synonym: ESCOBAR SYNDROME
Synonym: EVMPS
Synonym: Escobar Syndrome
Synonym: Escobar syndrome
Synonym: Escobar syndrome (disorder)
Synonym: Familial Pterygium Syndrome
Synonym: MULTIPLE PTERYGIUM SYNDROME
Synonym: MULTIPLE PTERYGIUM SYNDROME, ESCOBAR VARIANT
Synonym: MULTIPLE PTERYGIUM SYNDROME, NONLETHAL TYPE
Synonym: Multiple Pterygium Syndrome, Escobar Variant
Tree Number: T10.5.7
database_cross_reference: CHV:0000025871
database_cross_reference: JABL:471
database_cross_reference: MEDCIN:359987
database_cross_reference: MSH:C537377
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101039
database_cross_reference: NCI_NICHD:C101039
database_cross_reference: OMIM:100730
database_cross_reference: OMIM:163950
database_cross_reference: OMIM:265000
database_cross_reference: RCD:PKy78
database_cross_reference: SNMI:D4-00903
database_cross_reference: SNOMEDCT_US:205819008
database_cross_reference: SNOMEDCT_US:80773006

mitochondrial DNA depletion syndrome 1
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028968
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 1 (MNGIE TYPE)
Synonym: MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME
Synonym: MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME, TYMP-RELATED
Synonym: MNGIE
Synonym: MNGIE Disease
Synonym: MNGIE Syndrome
Synonym: MNGIE, TYMP-RELATED
Synonym: MTDPS1
Synonym: MYONEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME
Synonym: Mitochondrial DNA Depletion Syndrome 1
Tree Number: T10.6.2.1.5
database_cross_reference: CHV:0000051558
database_cross_reference: CSP:5000-0048
database_cross_reference: DO:DOID:0080119
database_cross_reference: MSH:C537477
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C119678
database_cross_reference: OMIM:131222
database_cross_reference: OMIM:603041
database_cross_reference: SNOMEDCT_US:722060007

mitochondrial DNA depletion syndrome 2
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028967
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL DNA DEPLETION MYOPATHY, TK2-RELATED
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 2 (MYOPATHIC TYPE)
Synonym: MTDPS2
Synonym: Mitochondrial DNA depletion syndrome 2 myopathic type
Synonym: TK2-related mitochondrial DNA depletion myopathy
Synonym: TK2-related mitochondrial DNA depletion syndrome myopathic form
Synonym: TK2-related mitochondrial deoxyribonucleic acid depletion syndrome myopathic form
Synonym: TK2-related mitochondrial deoxyribonucleic acid depletion syndrome myopathic form (disorder)
Tree Number: T10.6.2.1.4
database_cross_reference: DO:DOID:0080120
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:188250
database_cross_reference: OMIM:609560
database_cross_reference: SNOMEDCT_US:703527003

mitochondrial DNA depletion syndrome 3
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028969
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE)
Synonym: MTDPS3
Tree Number: T10.6.2.1.6
database_cross_reference: DO:DOID:0080121
database_cross_reference: OMIM:251880
database_cross_reference: OMIM:601465

mitochondrial DNA depletion syndrome 4a
type: Class
subclass of: mitochondrial metabolism disease
definition: A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions.
PMOID: PMO:00028984
Subclass_of: mitochondrial metabolism disease
Synonym: AHD
Synonym: AHS
Synonym: ALPER SYNDROME
Synonym: ALPERS DIFFUSE DEGENERATION OF CEREBRAL GRAY MATTER WITH HEPATIC CIRRHOSIS
Synonym: ALPERS DIS
Synonym: ALPERS PROGRESSIVE INFANTILE POLIODYSTROPHY
Synonym: ALPERS SYNDROME
Synonym: ALPERS-HUTTENLOCHER SYNDROME
Synonym: Alper Disease
Synonym: Alper Syndrome
Tree Number: T10.6.2.1.21
database_cross_reference: CCPSS:0062160
database_cross_reference: CHV:0000020691
database_cross_reference: DO:DOID:0080122
database_cross_reference: DO:DOID:1442
database_cross_reference: ICD10CM:G31.81
database_cross_reference: MDR:10062943
database_cross_reference: MEDCIN:36372
database_cross_reference: MSH:D002549
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:330.8
database_cross_reference: NCI:C35257
database_cross_reference: NCI_NICHD:C35257
database_cross_reference: OMIM:174763
database_cross_reference: OMIM:203700
database_cross_reference: RCD:F10y0
database_cross_reference: SNM:D-8530
database_cross_reference: SNM:D-8745
database_cross_reference: SNMI:DA-20160
database_cross_reference: SNOMEDCT_US:20415001

mitochondrial DNA depletion syndrome 4b
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028985
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 4B (MNGIE TYPE)
Synonym: MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME, POLG-RELATED
Synonym: MNGIE, POLG-RELATED
Synonym: MTDPS4B
Tree Number: T10.6.2.1.22
database_cross_reference: DO:DOID:0080123
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:174763
database_cross_reference: OMIM:613662

mitochondrial DNA depletion syndrome 5
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028972
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 5 (ENCEPHALOMYOPATHIC WITH OR WITHOUT METHYLMALONIC ACIDURIA)
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME, ENCEPHALOMYOPATHIC FORM, WITH OR WITHOUT METHYLMALONIC ACIDURIA, AUTOSOMAL RECESSIVE, SUCLA2-RELATED
Synonym: MTDPS5
Tree Number: T10.6.2.1.9
database_cross_reference: DO:DOID:0080124
database_cross_reference: OMIM:612073

mitochondrial DNA depletion syndrome 6
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028971
Subclass_of: mitochondrial metabolism disease
Synonym: IOSCA
Synonym: Infantile onset spinocerebellar ataxia
Synonym: Infantile-Onset Spinocerebellar Ataxia
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 7 (HEPATOCEREBRAL TYPE)
Synonym: MTDPS7
Synonym: OHAHA SYNDROME
Synonym: OHAHA Syndrome
Synonym: OPHTHALMOPLEGIA, HYPOTONIA, ATAXIA, HYPOACUSIS, AND ATHETOSIS
Synonym: Ophthalmoplegia, hypotonia, ataxia, hypacusis, and athetosis
Synonym: SCA8, FORMERLY
Tree Number: T10.6.2.1.8
database_cross_reference: DO:DOID:0050556
database_cross_reference: DO:DOID:0080125
database_cross_reference: MSH:C535523
database_cross_reference: OMIM:271245
database_cross_reference: OMIM:606075

mitochondrial DNA depletion syndrome 7
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028973
Subclass_of: mitochondrial metabolism disease
Synonym: NAVAJO FAMILIAL NEUROGENIC ARTHROPATHY
Synonym: Navajo Familial Neurogenic Arthropathy
Tree Number: T10.6.2.1.10
database_cross_reference: DO:DOID:0080126
database_cross_reference: MSH:C538344
database_cross_reference: OMIM:256810

mitochondrial DNA depletion syndrome 8a
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028983
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME, RRM2B-RELATED
Synonym: MNGIE, RRM2B-RELATED
Synonym: Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Rrm2b-Related
Synonym: Mngie, Rrm2b-Related
Tree Number: T10.6.2.1.20
database_cross_reference: DO:DOID:0080127
database_cross_reference: MSH:C537477
database_cross_reference: OMIM:612075

mitochondrial DNA depletion syndrome 9
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028970
Subclass_of: mitochondrial metabolism disease
Synonym: LACTIC ACIDOSIS, FATAL INFANTILE, FORMERLY
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 9 (ENCEPHALOMYOPATHIC TYPE WITH METHYLMALONIC ACIDURIA)
Synonym: MTDPS9
Tree Number: T10.6.2.1.7
database_cross_reference: DO:DOID:0080128
database_cross_reference: OMIM:245400
database_cross_reference: OMIM:611224

mitochondrial DNA depletion syndrome 11
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028987
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 11
Synonym: MTDPS11
Tree Number: T10.6.2.1.24
database_cross_reference: DO:DOID:0080129
database_cross_reference: OMIM:615076
database_cross_reference: OMIM:615084

mitochondrial DNA depletion syndrome 12
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028988
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 12B (CARDIOMYOPATHIC TYPE), AUTOSOMAL RECESSIVE
Synonym: MTDPS12B
Tree Number: T10.6.2.1.25
database_cross_reference: DO:DOID:0080130
database_cross_reference: OMIM:103220
database_cross_reference: OMIM:615418

mitochondrial DNA depletion syndrome 13
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028989
Subclass_of: mitochondrial metabolism disease
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 13 (ENCEPHALOMYOPATHIC TYPE)
Synonym: MTDPS13
Tree Number: T10.6.2.1.26
database_cross_reference: DO:DOID:0080131
database_cross_reference: OMIM:605654
database_cross_reference: OMIM:615471

Sengers syndrome
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028993
Subclass_of: mitochondrial metabolism disease
Synonym: CARDIOMYOPATHY AND CATARACT
Synonym: Cardiomyopathy and cataract
Synonym: Cataract and cardiomyopathy
Synonym: Congenital cataract, hypertrophic cardiomyopathy, mitochondrial myopathy syndrome
Synonym: Congenital cataract, hypertrophic cardiomyopathy, mitochondrial myopathy syndrome (disorder)
Synonym: MITOCHONDRIAL DNA DEPLETION SYNDROME 10 (CARDIOMYOPATHIC TYPE)
Synonym: MTDPS10
Synonym: SENGERS SYNDROME
Synonym: mitochondrial DNA depletion syndrome 10
Tree Number: T10.6.2.1.30
database_cross_reference: DO:DOID:0080132
database_cross_reference: MSH:C538280
database_cross_reference: OMIM:212350
database_cross_reference: OMIM:610345
database_cross_reference: SNOMEDCT_US:717812000

multiple mitochondrial dysfunctions syndrome 1
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028976
Subclass_of: mitochondrial metabolism disease
Synonym: MMDS
Synonym: MMDS1
Synonym: MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 1
Tree Number: T10.6.2.1.13
database_cross_reference: DO:DOID:0080133
database_cross_reference: OMIM:605711
database_cross_reference: OMIM:608100

multiple mitochondrial dysfunctions syndrome 2
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028977
Subclass_of: mitochondrial metabolism disease
Synonym: MMDS2
Synonym: MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 2 WITH HYPERGLYCINEMIA
Tree Number: T10.6.2.1.14
database_cross_reference: DO:DOID:0080134
database_cross_reference: OMIM:613183
database_cross_reference: OMIM:614299

multiple mitochondrial dysfunctions syndrome 3
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028974
Subclass_of: mitochondrial metabolism disease
Synonym: MMDS3
Synonym: MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 3
Tree Number: T10.6.2.1.11
database_cross_reference: DO:DOID:0080135
database_cross_reference: OMIM:615330

multiple mitochondrial dysfunctions syndrome 4
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028975
Subclass_of: mitochondrial metabolism disease
Synonym: MMDS4
Synonym: MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 4
Tree Number: T10.6.2.1.12
database_cross_reference: DO:DOID:0080136
database_cross_reference: OMIM:615317
database_cross_reference: OMIM:616370

multiple congenital anomalies-hypotonia-seizures syndrome 1
type: Class
subclass of: syndrome
PMOID: PMO:00025188
Subclass_of: syndrome
Synonym: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 3
Synonym: GPIBD3
Synonym: MCAHS1
Synonym: MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 1
Tree Number: T10.1.69
database_cross_reference: DO:DOID:0080138
database_cross_reference: OMIM:606097
database_cross_reference: OMIM:614080

multiple congenital anomalies-hypotonia-seizures syndrome 2
type: Class
subclass of: syndrome
PMOID: PMO:00025187
Subclass_of: syndrome
Synonym: EIEE20
Synonym: EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 20
Synonym: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 4
Synonym: GPIBD4
Synonym: MCAHS2
Synonym: MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 2
Tree Number: T10.1.68
database_cross_reference: DO:DOID:0080139
database_cross_reference: OMIM:300868
database_cross_reference: OMIM:311770

multiple congenital anomalies-hypotonia-seizures syndrome 3
type: Class
subclass of: syndrome
PMOID: PMO:00025189
Subclass_of: syndrome
Synonym: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 7
Synonym: GPIBD7
Synonym: MCAHS3
Synonym: MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 3
Tree Number: T10.1.70
database_cross_reference: DO:DOID:0080140
database_cross_reference: OMIM:610272
database_cross_reference: OMIM:615398

mosaic variegated aneuploidy syndrome 1
type: Class
subclass of: syndrome
PMOID: PMO:00025198
Subclass_of: syndrome
Synonym: Instability mitotic non disjunction syndrome
Synonym: MOSAIC VARIEGATED ANEUPLOIDY SYNDROME
Synonym: MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 1
Synonym: MVA SYNDROME
Synonym: MVA Syndrome
Synonym: MVA1
Synonym: Mosaic Variegated Aneuploidy Syndrome
Synonym: Mosaic Variegated Aneuploidy Syndrome 1
Synonym: Mosaic variegated aneuploidy syndrome
Synonym: Mosaic variegated aneuploidy syndrome (disorder)
Tree Number: T10.1.76
database_cross_reference: DO:DOID:0080141
database_cross_reference: MSH:C536987
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C128192
database_cross_reference: OMIM:257300
database_cross_reference: OMIM:602860
database_cross_reference: SNOMEDCT_US:700056005

mosaic variegated aneuploidy syndrome 2
type: Class
subclass of: syndrome
PMOID: PMO:00025199
Subclass_of: syndrome
Synonym: MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 2
Synonym: MVA2
Tree Number: T10.1.77
database_cross_reference: DO:DOID:0080142
database_cross_reference: OMIM:607951
database_cross_reference: OMIM:614114

medium chain acyl-CoA dehydrogenase deficiency
type: Class
subclass of: lipid metabolism disorder
definition: A lipid metabolism disorder that is characterized by a deficiency of the enzyme medium chain acyl-CoA dehydrogenase that results in the inability to convert medium chain fatty acids to energy, particularly during fasting.
PMOID: PMO:00029281
Subclass_of: lipid metabolism disorder
Synonym: ACADM DEFICIENCY
Synonym: ACADM Deficiency
Synonym: ACADMD
Synonym: ACYL-CoA DEHYDROGENASE, MEDIUM-CHAIN, DEFICIENCY OF
Synonym: Acyl-CoA Dehydrogenase, Medium-Chain Deficiency
Synonym: Acyl-CoA dehydrogenase, medium chain, deficiency of
Synonym: Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency of
Synonym: CARNITINE DEFICIENCY SECONDARY TO MEDIUM-CHAIN ACYL-CoA DEHYDROGENASE DEFICIENCY
Synonym: Carnitine Deficiency Secondary To Medium-Chain Acyl-Coa Dehydrogenase Deficiency
Synonym: Deficiency of medium-chain acyl-CoA dehydrogenase
Tree Number: T10.6.2.18.12
database_cross_reference: CHV:0000021180
database_cross_reference: DO:DOID:0080153
database_cross_reference: ICD10CM:E71.311
database_cross_reference: LNC:LA12509-8
database_cross_reference: LNC:LP56790-6
database_cross_reference: LNC:MTHU021618
database_cross_reference: MDR:10072654
database_cross_reference: MEDCIN:312728
database_cross_reference: MSH:C536038
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.85
database_cross_reference: NCI:C84538
database_cross_reference: NCI_NICHD:C84538
database_cross_reference: OMIM:201450
database_cross_reference: OMIM:607008
database_cross_reference: OMIM:MTHU014730
database_cross_reference: RCD:X40UI
database_cross_reference: SNMI:DA-20050
database_cross_reference: SNOMEDCT_US:128596003
database_cross_reference: SNOMEDCT_US:393571006
database_cross_reference: SNOMEDCT_US:394513008
database_cross_reference: SNOMEDCT_US:74351001

short chain acyl-CoA dehydrogenase deficiency
type: Class
subclass of: lipid metabolism disorder
definition: A lipid metabolism disorder that is characterized by deficiency of the enzyme short chain acyl-CoA dehydrogenase that results in the inability to convert short chain fatty acids.
PMOID: PMO:00029279
Subclass_of: lipid metabolism disorder
Synonym: ACADS DEFICIENCY
Synonym: ACADSD
Synonym: ACYL-CoA DEHYDROGENASE, SHORT-CHAIN, DEFICIENCY OF
Synonym: Acads Deficiency
Synonym: Acyl-CoA Dehydrogenase, Short-Chain Deficiency
Synonym: Acyl-Coa Dehydrogenase, Short-Chain, Deficiency Of
Synonym: Butyryl-CoA Dehydrogenase Deficiency
Synonym: Butyryl-CoA dehydrogenase def
Synonym: Butyryl-CoA dehydrogenase deficiency
Synonym: Deficiency of Butyryl-Coa Dehydrogenase
Tree Number: T10.6.2.18.10
database_cross_reference: DO:DOID:0080154
database_cross_reference: ICD10CM:E71.312
database_cross_reference: LNC:LA12524-7
database_cross_reference: LNC:LP174562-1
database_cross_reference: LNC:MTHU047545
database_cross_reference: MDR:10072276
database_cross_reference: MDR:10072279
database_cross_reference: MDR:10072655
database_cross_reference: MEDCIN:312727
database_cross_reference: MSH:C537596
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.85
database_cross_reference: NCI:C84539
database_cross_reference: NCI:C98863
database_cross_reference: NCI_NICHD:C98863
database_cross_reference: OMIM:201470
database_cross_reference: OMIM:606885
database_cross_reference: RCD:X40UH
database_cross_reference: SNOMEDCT_US:124166007

very long chain acyl-CoA dehydrogenase deficiency
type: Class
subclass of: lipid metabolism disorder
definition: A lipid metabolism disorder that is characterized by deficiency of the enzyme very long chain acyl-CoA dehydrogenase that results in the inability to convert very long chain fatty acids.
PMOID: PMO:00029256
Subclass_of: lipid metabolism disorder
Synonym: ACADVLD
Synonym: ACYL-CoA DEHYDROGENASE, VERY LONG-CHAIN, DEFICIENCY OF
Synonym: Acadvl
Synonym: Acyl-CoA Dehydrogenase, Very Long-Chain Deficiency
Synonym: Acyl-CoA Dehydrogenase, Very Long-Chain, Deficiency of
Synonym: Acyl-Coa Dehydrogenase Very Long Chain Deficiency
Synonym: Pearson Marrow-Pancreas Syndrome
Synonym: Pearson's marrow-pancreas syndrome
Synonym: SIDEROBLASTIC ANEMIA WITH MARROW CELL VACUOLIZATION AND EXOCRINE PANCREATIC DYSFUNCTION
Synonym: Sideroblastic anemia with marrow cell vacuolization and exocrine pancreatic dysfunction
Tree Number: T10.6.2.18.3
database_cross_reference: DO:DOID:0080155
database_cross_reference: LNC:LA12531-2
database_cross_reference: MDR:10072274
database_cross_reference: MDR:10072277
database_cross_reference: MDR:10072656
database_cross_reference: MEDCIN:312729
database_cross_reference: MSH:C536353
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98647
database_cross_reference: NCI_NICHD:C98647
database_cross_reference: OMIM:201475
database_cross_reference: OMIM:557000
database_cross_reference: OMIM:609575
database_cross_reference: RCD:X40UK
database_cross_reference: SNOMEDCT_US:237997005

otulipenia
type: Class
subclass of: immune system disease
definition: An immune system disease that is characterized by neonatal onset of recurrent fever, erythematous rash with painful nodules, painful joints, and lipodystrophy and has_material_basis_in autosomal recessive inheritance of homozygous loss-of-function mutations in the OTULIN gene encoding a deubiquitinase with linear linkage specificity on chromosome 5p15.
PMOID: PMO:00032702
Subclass_of: immune system disease
Synonym: AIPDS
Synonym: AUTOINFLAMMATION, PANNICULITIS, AND DERMATOSIS SYNDROME
Synonym: ORAS
Synonym: OTULIN-RELATED AUTOINFLAMMATORY SYNDROME
Synonym: OTULIPENIA
Synonym: autoinflammation, panniculitis and dermatosis syndrome
Synonym: otulin-related autoinflammatory syndrome
Tree Number: T10.8.6.2
database_cross_reference: DO:DOID:0080163
database_cross_reference: OMIM:615712
database_cross_reference: OMIM:617099

esophageal atresia/tracheoesophageal fistula
type: Class
subclass of: gastrointestinal system disease
definition: A gastrointestinal system disease that is characterized by abnormal development of the esophagus and trachea where the upper esophagus does not connect (atresia) to the lower esophagus and stomach and may also include tracheoesophageal fistula where the esophagus and the trachea are abnormally connected which allows fluids from the esophagus to get into the airways and interfere with breathing.
PMOID: PMO:00033631
Subclass_of: gastrointestinal system disease
Synonym: ESOPHAGEAL ATRESIA WITH OR WITHOUT TRACHEOESOPHAGEAL FISTULA
Synonym: Ea-Tef
Synonym: Esophageal Atresia Tracheoesophageal Fistula
Synonym: Esophageal Atresia-Tracheoesophageal Fistula
Synonym: Esophageal atresia with or without tracheoesophageal fistula
Synonym: TRACHEOESOPHAGEAL FISTULA WITH OR WITHOUT ESOPHAGEAL ATRESIA
Synonym: Tracheoesophageal fistula with or without esophageal atresia
Synonym: esophageal atresia and/or tracheoesophageal fistula
Synonym: tracheoesophageal fistula with or without esohageal atresia
Tree Number: T10.8.11.9
database_cross_reference: DO:DOID:0080171
database_cross_reference: MSH:C531835
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:189960

thiopurine S-methyltransferase deficiency
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disease that is characterized by significantly reduced activity of an enzyme that helps the body process drugs called thiopurines.
PMOID: PMO:00029155
Subclass_of: inherited metabolic disorder
Synonym: THIOPURINE S-METHYLTRANSFERASE DEFICIENCY
Synonym: THIOPURINES, POOR METABOLISM OF, 1
Synonym: THPM1
Synonym: TPMT - Thiopurine methyltransferase deficiency
Synonym: TPMT DEFICIENCY
Synonym: TPMT Deficiency
Synonym: TPMT deficiency
Synonym: TPMT-Thiopur methyltransf def
Synonym: TPMTD
Synonym: Thiopur methyltransferase
Tree Number: T10.6.2.12
database_cross_reference: DO:DOID:0080172
database_cross_reference: MSH:C536512
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4389
database_cross_reference: OMIM:187680
database_cross_reference: OMIM:610460
database_cross_reference: RCD:X40Ul
database_cross_reference: SNOMEDCT_US:238012003

bladder exstrophy-epispadias-cloacal exstrophy complex
type: Class
subclass of: physical disorder
definition: A physical disorder that is characterized as a spectrum of anomalies involving the urinary tract, genital tract, musculoskeletal system and sometimes the intestinal tract.
PMOID: PMO:00028276
Subclass_of: physical disorder
Synonym: OEIS COMPLEX
Synonym: OEIS Complex
Synonym: OEIS Syndrome
Synonym: OEIS complex
Synonym: OMPHALOCELE-EXSTROPHY-IMPERFORATE ANUS-SPINAL DEFECTS
Synonym: Omphalocele exstrophy imperforate anus
Synonym: Omphalocele, exstrophy of the cloaca, imperforate anus, and spinal defects
Synonym: Omphalocele-Exstrophy-Imperforate Anus-Spinal Defects
Synonym: cloacal exstrophy
Synonym: exstrophy-epispadias complex
Tree Number: T10.4.17
database_cross_reference: DO:DOID:0080173
database_cross_reference: DO:DOID:0080175
database_cross_reference: MSH:C537748
database_cross_reference: NCI:C99142
database_cross_reference: NCI_NICHD:C99142
database_cross_reference: OMIM:258040

bladder exstrophy
type: Class
subclass of: bladder exstrophy-epispadias-cloacal exstrophy complex
PMOID: PMO:00028277
Subclass_of: bladder exstrophy-epispadias-cloacal exstrophy complex
Synonym: BLADDER EXSTROPHY
Synonym: Bladder Exstrophies
Synonym: Bladder Exstrophy
Synonym: Bladder Exstrophy [Disease/Finding]
Synonym: Bladder Extrophies
Synonym: Bladder Extrophy
Synonym: Bladder exstrophy
Synonym: Congenital ectopic bladder
Synonym: Congenital extroversion of urinary bladder
Synonym: EXSTROPHY OF BLADDER
Tree Number: T10.4.17.1
database_cross_reference: CCPSS:0061013
database_cross_reference: CHV:0000001953
database_cross_reference: HPO:HP:0002836
database_cross_reference: ICD10:Q64.1
database_cross_reference: ICD10AM:Q64.1
database_cross_reference: ICD10CM:Q64.1
database_cross_reference: ICD10CM:Q64.10
database_cross_reference: ICD10CM:Q64.19
database_cross_reference: ICD9CM:753.5
database_cross_reference: LCH:U000601
database_cross_reference: LCH_NW:sh85014741
database_cross_reference: MDR:10010453
database_cross_reference: MDR:10014151
database_cross_reference: MDR:10015720
database_cross_reference: MDR:10048597
database_cross_reference: MEDCIN:211264
database_cross_reference: MEDCIN:315114
database_cross_reference: MEDCIN:7456
database_cross_reference: MSH:D001746
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:753.5
database_cross_reference: NCI:C123207
database_cross_reference: NCI_NICHD:C123207
database_cross_reference: NDFRT:N0000000561
database_cross_reference: OMIM:600057
database_cross_reference: OMIM:MTHU006673
database_cross_reference: RCD:PD5..
database_cross_reference: RCD:PD5z.
database_cross_reference: SNM:M-21550
database_cross_reference: SNMI:D4-01542
database_cross_reference: SNOMEDCT_US:156977001
database_cross_reference: SNOMEDCT_US:204996009
database_cross_reference: SNOMEDCT_US:204997000
database_cross_reference: SNOMEDCT_US:268335001
database_cross_reference: SNOMEDCT_US:61758007

cloacal exstrophy
type: Class
subclass of: bladder exstrophy-epispadias-cloacal exstrophy complex
definition: A physical disorder that is characterized as a spectrum of anomalies involving the urinary tract, genital tract, musculoskeletal system and sometimes the intestinal tract.
PMOID: PMO:00028278
Subclass_of: bladder exstrophy-epispadias-cloacal exstrophy complex
Synonym: OEIS COMPLEX
Synonym: OEIS Complex
Synonym: OEIS Syndrome
Synonym: OEIS complex
Synonym: OMPHALOCELE-EXSTROPHY-IMPERFORATE ANUS-SPINAL DEFECTS
Synonym: Omphalocele exstrophy imperforate anus
Synonym: Omphalocele, exstrophy of the cloaca, imperforate anus, and spinal defects
Synonym: Omphalocele-Exstrophy-Imperforate Anus-Spinal Defects
Synonym: bladder exstrophy-epispadias-cloacal exstrophy complex
Synonym: exstrophy-epispadias complex
Tree Number: T10.4.17.2
database_cross_reference: DO:DOID:0080173
database_cross_reference: DO:DOID:0080175
database_cross_reference: MSH:C537748
database_cross_reference: NCI:C99142
database_cross_reference: NCI_NICHD:C99142
database_cross_reference: OMIM:258040

mucositis
type: Class
subclass of: gastrointestinal system disease
definition: A gastrointestinal system disease that is characterized by painful inflammation and ulceration of the mucous membranes lining the digestive tract.
PMOID: PMO:00033740
Subclass_of: gastrointestinal system disease
Synonym: Catarrhal inflammation
Synonym: Catarrhal inflammation, NOS
Synonym: INFLAMMATION MUCOUS MEMBRANE
Synonym: Inflammation mucous membrane
Synonym: Inflammatory disease of mucous membrane
Synonym: Inflammatory disease of mucous membrane (disorder)
Synonym: MUCOSITIS
Synonym: MUCOSITIS NOS
Synonym: MUCOUS MEMBRANE INFLAMMATION
Synonym: Mucitis
Tree Number: T10.8.11.12
database_cross_reference: CCPSS:0003816
database_cross_reference: CHV:0000023689
database_cross_reference: CST:MUCOUS MEM DIS
database_cross_reference: DO:DOID:0080178
database_cross_reference: DXP:U002656
database_cross_reference: MDR:10021960
database_cross_reference: MDR:10028116
database_cross_reference: MDR:10028117
database_cross_reference: MDR:10028127
database_cross_reference: MDR:10028129
database_cross_reference: MEDCIN:310774
database_cross_reference: MSH:D052016
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:528.00
database_cross_reference: NCI:C115965
database_cross_reference: NCI_NCI-GLOSS:CDR0000045789
database_cross_reference: NCI_NICHD:C115965
database_cross_reference: PDQ:CDR0000491691
database_cross_reference: RCD:J080.
database_cross_reference: SNM:M-40300
database_cross_reference: SNMI:D0-A0100
database_cross_reference: SNMI:M-40500
database_cross_reference: SNOMEDCT_US:87749000
database_cross_reference: SNOMEDCT_US:95361005

Zika virus congenital syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized in neonates by microcephaly, craniofacial disproportion, spasticity, seizures, irritability and brainstem dysfunction including feeding difficulties, ocular abnormalities and findings on neuroimaging such as calcifications, cortical disorders and ventriculomegaly and has_material_basis_in the acquisition of Zika virus infection in utero.
PMOID: PMO:00025179
Subclass_of: syndrome
Synonym: ZIKV congenital infection
Tree Number: T10.1.60
database_cross_reference: DO:DOID:0080180

malignant hemangioma
type: Class
subclass of: cell type cancer
definition: A cell type cancer of vascular origin, characterized by proliferation of endothelial cells in and about the vascular lumen.
PMOID: PMO:00025402
Subclass_of: cell type cancer
Synonym: Malignant haemangioma
Synonym: Malignant hemangioma
Synonym: Malignant hemangioma (morphologic abnormality)
Tree Number: T10.2.1.1.7
database_cross_reference: DO:DOID:0080189
database_cross_reference: RCD:X77oz
database_cross_reference: RCDAE:X77oz
database_cross_reference: SNOMEDCT_US:253052008

PTEN hamartoma tumor syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized as a spectrum of disorders (Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, PTEN-related Proteus syndrome, and Proteus-like syndrome) caused by germline mutations of the PTEN gene.
PMOID: PMO:00025215
Subclass_of: syndrome
Synonym: PHTS
Synonym: PTEN HAMARTOMA TUMOR SYNDROME
Synonym: PTEN Hamartoma Tumor Syndrome
Synonym: PTEN hamartoma tumor syndrome (disorder)
Synonym: PTEN hamartoma tumour syndrome
Tree Number: T10.1.83
database_cross_reference: DO:DOID:0080191
database_cross_reference: MSH:D006223
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:601728
database_cross_reference: SNOMEDCT_US:722859001

Carey-Fineman-Ziter syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by hypotonia, Moebius sequence (bilateral congenital facial palsy with impairment of ocular abduction), Pierre Robin complex (micrognathia, glossoptosis, and high-arched or cleft palate), delayed motor milestones, and failure to thrive.
PMOID: PMO:00025135
Subclass_of: syndrome
Tree Number: T10.1.20
database_cross_reference: DO:DOID:0080194

Peters plus syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by anterior chamber eye anomalies, short limbs with broad distal extremities, characteristic facial features, cleft lip/palate, and variable developmental delay/intellectual disability.
PMOID: PMO:00025129
Subclass_of: syndrome
Synonym: KRAUSE-KIVLIN SYNDROME
Synonym: Krause-Kivlin syndrome
Synonym: Krause-Van Schooneveld-Kivlin Syndrome
Synonym: Krause-van Schooneveld-Kivlin syndrome
Synonym: PETERS ANOMALY WITH SHORT-LIMB DWARFISM
Synonym: PETERS-PLUS SYNDROME
Synonym: Peters Anomaly With Short-Limb Dwarfism
Synonym: Peters Anomaly-Short Limb Dwarfism Syndrome
Synonym: Peters Plus Syndrome
Synonym: Peters anomaly with short limb dwarfism
Tree Number: T10.1.14
database_cross_reference: CHV:0000048953
database_cross_reference: DO:DOID:0080201
database_cross_reference: JABL:390
database_cross_reference: MSH:C537617
database_cross_reference: NCI:C123436
database_cross_reference: OMIM:261540
database_cross_reference: OMIM:610308
database_cross_reference: SNOMEDCT_US:449817000

renal hypoplasia
type: Class
subclass of: kidney disease
definition: A kidney disease that is characterized by abnormally small kidneys with normal morphology and reduced number of nephrons.
PMOID: PMO:00033027
Subclass_of: kidney disease
Synonym: Congenital hypoplasia of kidney
Synonym: Congenital hypoplasia of kidney (disorder)
Synonym: Hypoplasia of kidney
Synonym: Hypoplasia of kidneys
Synonym: Hypoplastic kidney
Synonym: Hypoplastic kidneys
Synonym: KIDNEY, HYPOPLASIA
Synonym: Renal hypoplasia
Synonym: Renal hypoplasia (disorder)
Synonym: Renal hypoplasia, unspecified
Tree Number: T10.8.7.9.11
database_cross_reference: CHV:0000026017
database_cross_reference: DO:DOID:0080204
database_cross_reference: DXP:U000981
database_cross_reference: HPO:HP:0000089
database_cross_reference: ICD10:Q60.5
database_cross_reference: ICD10AM:Q60.5
database_cross_reference: ICD10CM:Q60.5
database_cross_reference: MDR:10049102
database_cross_reference: MEDCIN:337459
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:753.0
database_cross_reference: OMIM:MTHU001428
database_cross_reference: OMIM:MTHU009946
database_cross_reference: OMIM:MTHU019488
database_cross_reference: RCD:PD03.
database_cross_reference: SNM:M-21300
database_cross_reference: SNMI:D4-71014
database_cross_reference: SNOMEDCT_US:204946008
database_cross_reference: SNOMEDCT_US:32659003

CAKUT
type: Class
subclass of: urinary system disease
definition: A urinary system disease characterized by structural malformations in the kidney and/or urinary tract containing vesicoureteral reflux.
PMOID: PMO:00032976
Subclass_of: urinary system disease
Synonym: Cakut
Synonym: Congenital Anomalies Of Kidney And Urinary Tract
Synonym: Congenital anomalies of the kidney and urinary tract
Synonym: Congenital anomalies of the kidney and urinary tract (CAKUT)
Synonym: Renal or urinary tract malformation
Tree Number: T10.8.7.6
database_cross_reference: DO:DOID:0080205
database_cross_reference: MSH:C566906
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU041209

CAKUT1
type: Class
subclass of: CAKUT
definition: A CAKUT that has_material_ basis_in heterozygous mutation in the DSTYK gene on chromosome 1q32.
PMOID: PMO:00032977
Subclass_of: CAKUT
Synonym: RENAL HYPODYSPLASIA, NONSYNDROMIC, 1
Synonym: RHDNS1
Synonym: Renal Hypodysplasia, Nonsyndromic, 1
Tree Number: T10.8.7.6.1
database_cross_reference: DO:DOID:0080206
database_cross_reference: MSH:C563661
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:610805

CAKUT2
type: Class
subclass of: CAKUT
definition: A CAKUT that has_material_basis_in heterozygous mutation in the TBX18 gene on chromosome 6q14.
PMOID: PMO:00032978
Subclass_of: CAKUT
Synonym: CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT 2
Synonym: Obstruction of Pelviureteric Junction
Synonym: Obstruction of pelviureteric junction
Synonym: Obstruction of pelviureteric junction (disorder)
Synonym: PELVIURETERIC JUNCTION OBSTRUCTION
Synonym: PUJ - Pelviureteric obstruction
Synonym: PUJ - Pelviureteric obstructn
Synonym: PUJO
Synonym: PUO - Pelviureteric obstruction
Synonym: PUO - Pelviureteric obstructn
Tree Number: T10.8.7.6.2
database_cross_reference: DO:DOID:0080207
database_cross_reference: DO:DOID:0111145
database_cross_reference: HPO:HP:0000074
database_cross_reference: ICD10CM:Q62.39
database_cross_reference: MDR:10034232
database_cross_reference: MDR:10051749
database_cross_reference: MSH:C537373
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C99007
database_cross_reference: NCI_NICHD:C99007
database_cross_reference: OMIM:143400
database_cross_reference: OMIM:604613
database_cross_reference: OMIM:MTHU008668
database_cross_reference: OMIM:MTHU018043
database_cross_reference: RCD:Xa9CE
database_cross_reference: SNMI:D7-11947
database_cross_reference: SNOMEDCT_US:95575002

Meckel syndrome 13
type: Class
subclass of: Meckel syndrome
PMOID: PMO:00028333
Subclass_of: Meckel syndrome
Tree Number: T10.5.1.2.9
database_cross_reference: DO:DOID:0080253

orofaciodigital syndrome XVI
type: Class
subclass of: orofaciodigital syndrome
PMOID: PMO:00028749
Subclass_of: orofaciodigital syndrome
Tree Number: T10.5.5.9
database_cross_reference: DO:DOID:0080254

primary ciliary dyskinesia 37
type: Class
subclass of: primary ciliary dyskinesia
PMOID: PMO:00028349
Subclass_of: primary ciliary dyskinesia
Tree Number: T10.5.1.3.15
database_cross_reference: DO:DOID:0080266

multiple mitochondrial dysfunctions syndrome 5
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028978
Subclass_of: mitochondrial metabolism disease
Tree Number: T10.6.2.1.15
database_cross_reference: DO:DOID:0080274

Joubert syndrome 30
type: Class
subclass of: Joubert syndrome
PMOID: PMO:00028302
Subclass_of: Joubert syndrome
Tree Number: T10.5.1.1.10
database_cross_reference: DO:DOID:0080275

Joubert syndrome 29
type: Class
subclass of: Joubert syndrome
PMOID: PMO:00028321
Subclass_of: Joubert syndrome
Tree Number: T10.5.1.1.29
database_cross_reference: DO:DOID:0080276

Joubert syndrome 31
type: Class
subclass of: Joubert syndrome
PMOID: PMO:00028304
Subclass_of: Joubert syndrome
Tree Number: T10.5.1.1.12
database_cross_reference: DO:DOID:0080277

Joubert syndrome 32
type: Class
subclass of: Joubert syndrome
PMOID: PMO:00028303
Subclass_of: Joubert syndrome
Tree Number: T10.5.1.1.11
database_cross_reference: DO:DOID:0080278

Joubert syndrome 33
type: Class
subclass of: Joubert syndrome
PMOID: PMO:00028305
Subclass_of: Joubert syndrome
Tree Number: T10.5.1.1.13
database_cross_reference: DO:DOID:0080279

orofaciodigital syndrome XVII
type: Class
subclass of: orofaciodigital syndrome
PMOID: PMO:00028743
Subclass_of: orofaciodigital syndrome
Tree Number: T10.5.5.3
database_cross_reference: DO:DOID:0080289

mixed sleep apnea
type: Class
subclass of: sleep apnea
definition: A sleep apnea that is characterized by a combination of central and obstructive sleep apnea.
PMOID: PMO:00027889
Subclass_of: sleep apnea
Synonym: Complex sleep apnea
Synonym: Mixed Central and Obstructive Sleep Apnea
Synonym: Mixed Sleep Apnea
Synonym: Mixed Sleep Apneas
Synonym: Mixed sleep apnea
Synonym: Mixed sleep apnea (disorder)
Synonym: Mixed sleep apnoea
Synonym: Sleep Apnea, Mixed
Synonym: Sleep Apnea, Mixed Central and Obstructive
Synonym: Sleep Apneas, Mixed
Tree Number: T10.3.1.3.1
database_cross_reference: DO:DOID:0080302
database_cross_reference: MSH:D012891
database_cross_reference: RCD:X0086
database_cross_reference: RCDAE:X0086
database_cross_reference: SNOMEDCT_US:230493001

cleft palate-lateral synechia syndrome
type: Class
subclass of: physical disorder
definition: A physical disorder that is characterized by fusion of maxilla and mandible with autosomal dominant inheritance.
PMOID: PMO:00028261
Subclass_of: physical disorder
Synonym: CLEFT PALATE-LATERAL SYNECHIA SYNDROME
Synonym: CPLS - cleft palate-lateral synechia syndrome
Synonym: CPLS SYNDROME
Synonym: CPLS Syndrome
Synonym: CPLS syndrome
Synonym: Cleft Palate-Lateral Synechia Syndrome
Synonym: Cleft palate lateral synechia syndrome
Synonym: Cleft palate lateral synechia syndrome (disorder)
Synonym: Cleft palate-lateral synechia syndrome
Synonym: Cleft palate-lateral synechia syndrome (disorder)
Tree Number: T10.4.7
database_cross_reference: DO:DOID:0080313
database_cross_reference: JABL:232
database_cross_reference: MSH:C563047
database_cross_reference: OMIM:119550
database_cross_reference: OMIM:MTHU018926
database_cross_reference: SNOMEDCT_US:403772000

Tietz syndrome
type: Class
subclass of: monogenic disease
definition: An monogenic disease that is characterized by congenital profound bilateral sensorineural hearing loss and generalized albino-like hypopigmentation of skin, eyes and hair that has_material_basis_in mutation in the MITF gene on chromosome 3p13.
PMOID: PMO:00028736
Subclass_of: monogenic disease
Synonym: ALBINISM-DEAFNESS OF TIETZ
Synonym: Albinism and complete nerve deafness
Synonym: Albinism-deafness of Tietz
Synonym: Albinism-deafness syndrome of Tietz
Synonym: Albinism-deafness syndrome of Tietz (disorder)
Synonym: Generalized piebaldism and deafness
Synonym: HYPOPIGMENTATION/DEAFNESS OF TIETZ
Synonym: Hypopigmentation-deafness of Tietz
Synonym: TADS
Synonym: TIETZ ALBINISM-DEAFNESS SYNDROME
Tree Number: T10.5.3.5
database_cross_reference: DO:DOID:0090002
database_cross_reference: MSH:C536919
database_cross_reference: OMIM:103500
database_cross_reference: OMIM:156845
database_cross_reference: SNM:D-3749
database_cross_reference: SNOMEDCT_US:403805009

sitosterolemia
type: Class
subclass of: intestinal disease
definition: An intestinal disease that is characterized by autosomal recessive inheritance of unrestricted intestinal absorption of both cholesterol and plant-derived cholesterol-like molecules resulting in xanthomas, arthralgia, premature atherosclerosis, and hemolytic anemia with stomatocytosis and macrothrombocytopenia that has_material_basis_in homozygous or compound heterozygous mutation in the ABCG8 gene or in the ABCG5 gene, both of which are located on chromosome 2p21.
PMOID: PMO:00033542
Subclass_of: intestinal disease
Synonym: MACROTHROMBOCYTOPENIA/STOMATOCYTOSIS, MEDITERRANEAN
Synonym: Macrothrombocytopenia-Stomatocytosis, Mediterranean
Synonym: phytosterolemia
Tree Number: T10.8.11.8.7
database_cross_reference: DO:DOID:0090019
database_cross_reference: MSH:C537345
database_cross_reference: OMIM:210250

familial isolated deficiency of vitamin E
type: Class
subclass of: vitamin metabolic disorder
definition: A vitamin metabolic disorder characterized by progressive spino-cerebellar ataxia, loss of proprioception, areflexia, and marked deficiency in vitamin E that has_material_basis_in homozygous or compound heterozygous mutation in the TTPA gene on chromosome 8q12.
PMOID: PMO:00029157
Subclass_of: vitamin metabolic disorder
Synonym: ATAXIA, FRIEDREICH-LIKE, WITH SELECTIVE VITAMIN E DEFICIENCY
Synonym: AVED
Synonym: Ataxia with isolated vitamin E deficiency
Synonym: Ataxia with vitamin E deficiency
Synonym: Ataxia with vitamin E deficiency (disorder)
Synonym: Ataxia, Friedreich-Like, with Selective Vitamin E Deficiency
Synonym: FRIEDREICH-LIKE ATAXIA
Synonym: Familial Isolated Vitamin E Deficiency
Synonym: Familial isolated deficiency of vitamin E
Synonym: Familial isolated vitamin E deficiency
Tree Number: T10.6.2.13.1
database_cross_reference: DO:DOID:0090028
database_cross_reference: MSH:C535393
database_cross_reference: OMIM:277460
database_cross_reference: SNOMEDCT_US:702442008

corticosteroid-binding globulin deficiency
type: Class
subclass of: adrenal gland disease
PMOID: PMO:00033241
Subclass_of: adrenal gland disease
Synonym: CBG DEFICIENCY
Synonym: CBG Deficiency
Synonym: CORTICOSTEROID-BINDING GLOBULIN DEFICIENCY
Synonym: Corticosteroid-Binding Globulin Deficiency
Synonym: TRANSCORTIN DEFICIENCY
Synonym: Transcortin Deficiency
Tree Number: T10.8.8.6.4
database_cross_reference: MSH:C565152
database_cross_reference: OMIM:122500
database_cross_reference: OMIM:611489

D-bifunctional protein deficiency
type: Class
subclass of: peroxisomal disease
definition: A peroxisomal disease characterized by, in severe cases, infantile-onset of hypotonia, seizures, and abnormal facial features with most dieing before age 2 years that has_material_basis_in homozygous or compound heterozygous mutation in the HSD17B4 gene on chromosome 5q2.
PMOID: PMO:00029238
Subclass_of: peroxisomal disease
Synonym: 17-BETA-HYDROXYSTEROID DEHYDROGENASE IV DEFICIENCY
Synonym: 17-beta-hydroxysteroid dehydrogenase 4, deficiency of
Synonym: Bifunct peroxisomal enzyme def
Synonym: Bifunctional peroxisomal enzyme deficiency
Synonym: Bifunctional peroxisomal enzyme deficiency (disorder)
Synonym: D-BIFUNCTIONAL PROTEIN DEFICIENCY
Synonym: D-Bifunctional Enzyme Deficiency
Synonym: D-Bifunctional Protein Deficiency
Synonym: DBP DEFICIENCY
Synonym: Multifunctional Enzyme Deficiency
Tree Number: T10.6.2.16.1
database_cross_reference: DO:DOID:0090031
database_cross_reference: MSH:C537286
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C119676
database_cross_reference: OMIM:261515
database_cross_reference: OMIM:601860
database_cross_reference: RCD:X40Wp
database_cross_reference: SNOMEDCT_US:238068007

familial cold autoinflammatory syndrome
type: Class
subclass of: primary immunodeficiency disease
definition: A primary immunodeficiency disease characterized by recurrent episodes of maculopapular skin rash triggered by exposure to cold associated with low-grade fever, general malaise, eye redness and arthralgia/myalgia.
PMOID: PMO:00032697
Subclass_of: primary immunodeficiency disease
Synonym: CAPS1
Synonym: COLD HYPERSENSITIVITY
Synonym: COLD URTICARIA, FAMILIAL
Synonym: COLD-INDUCED AUTOINFLAMMATORY SYNDROME, FAMILIAL
Synonym: CRYOPYRIN-ASSOCIATED PERIODIC SYNDROME 1
Synonym: Cold Induced Autoinflammatory Syndrome, Familial
Synonym: Cold Urticaria, Familial
Synonym: Cold Urticarias, Familial
Synonym: Cold-Induced Autoinflammatory Syndrome, Familial
Synonym: FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1
Tree Number: T10.8.6.1.8
database_cross_reference: DO:DOID:0090061
database_cross_reference: DO:DOID:0090062
database_cross_reference: ICD10CM:M04.2
database_cross_reference: MDR:10064570
database_cross_reference: MDR:10064575
database_cross_reference: MDR:10071094
database_cross_reference: MSH:D056587
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C119053
database_cross_reference: NCI_NICHD:C119053
database_cross_reference: OMIM:120100
database_cross_reference: OMIM:606416
database_cross_reference: RCD:X508T
database_cross_reference: SNOMEDCT_US:238687000

Fanconi-like syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by pancytopenia, immune deficiency and cutaneous malignancies.
PMOID: PMO:00025121
Subclass_of: syndrome
Synonym: FANCONI-LIKE SYNDROME
Synonym: Fanconi like syndrome
Synonym: Fanconi-Like Syndrome
Synonym: Fanconi-like syndrome (disorder)
Synonym: SYNDROME FANCONI-LIKE
Synonym: Syndrome Fanconi-like
Tree Number: T10.1.6
database_cross_reference: CST:FANCONI SYND
database_cross_reference: DO:DOID:0090066
database_cross_reference: MDR:10016220
database_cross_reference: MDR:10042805
database_cross_reference: MSH:C536855
database_cross_reference: OMIM:227850
database_cross_reference: RCD:X30Jt
database_cross_reference: SNOMEDCT_US:236469003

ocular albinism with sensorineural deafness
type: Class
subclass of: genetic disease
PMOID: PMO:00028754
Subclass_of: genetic disease
Synonym: ALBINISM, OCULAR, WITH LATE-ONSET SENSORINEURAL DEAFNESS
Synonym: ALBINISM, OCULAR, WITH LATE-ONSET SENSORINEURAL DEAFNESS (disorder)
Synonym: Albinism ocular late onset sensorineural deafness
Synonym: Albinism, Ocular, With Late-Onset Sensorineural Deafness
Synonym: Albinism, Ocular, With Sensorineural Deafness
Synonym: DEAFNESS AND OCULAR ALBINISM
Synonym: Deafness and ocular albinism
Synonym: OASD
Synonym: OCULAR ALBINISM WITH SENSORINEURAL DEAFNESS
Synonym: Ocular albinism with late-onset sensorineural deafness
Tree Number: T10.5.8
database_cross_reference: MSH:C537043
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300650
database_cross_reference: SNOMEDCT_US:722054007

Bh4-deficient hyperphenylalaninemia A
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder characterized by autosomal recessive inheritance of hyperphenylalaninemia, depletion of the neurotransmitters dopamine and serotonin, and progressive cognitive and motor deficits that has material_basis_in mutation in the PTS gene on chromosome 11q23.1.
PMOID: PMO:00029197
Subclass_of: amino acid metabolic disorder
Synonym: 6-PYRUVOYL-TETRAHYDROPTERIN SYNTHASE DEFICIENCY
Synonym: 6-pyruvoyl-tetrahydropterin synthase deficiency
Synonym: HPABH4A
Synonym: HYPERPHENYLALANINEMIA, BH4-DEFICIENT, A
Synonym: HYPERPHENYLALANINEMIA, TETRAHYDROBIOPTERIN-DEFICIENT, DUE TO PTS DEFICIENCY
Synonym: Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency
Synonym: Hyperphenylalaninemia, BH4-Deficient, Type A
Synonym: Hyperphenylalaninemia, Tetrahydrobiopterin-Deficient, Due To PTS Deficiency
Synonym: PTS DEFICIENCY
Synonym: PTS Deficiency
Tree Number: T10.6.2.15.19
database_cross_reference: DO:DOID:0090106
database_cross_reference: MSH:C535325
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:261640
database_cross_reference: OMIM:612719

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome
type: Class
subclass of: hypersensitivity reaction disease
definition: A hypersensitivity reaction type II disease characterized by onset in infancy of refractory diarrhea, endocrinopathies, type 1 diabetes mellitus, and dermatitis that has material_basis_in mutation in the FOXP3 gene on chromosome Xp11.
PMOID: PMO:00032704
Subclass_of: hypersensitivity reaction disease
Synonym: X-linked autoimmunity-allergic dysregulation syndrome
Synonym: autoimmunity-immunodeficiency syndrome, X-linked
Synonym: AUTOIMMUNITY-IMMUNODEFICIENCY SYNDROME, X-LINKED
Synonym: Autoimmune enteropathy type 1
Synonym: Autoimmunity-Immunodeficiency Syndrome, X-Linked
Synonym: Congen diab mell secret diarrh
Synonym: Congen diab mell with fatal secretory diarrhea
Synonym: Congen diab mell with fatal secretory diarrhoea
Synonym: Congenital insulin-dependent diabetes mellitus with fatal secretory diarrhea
Synonym: Congenital insulin-dependent diabetes mellitus with fatal secretory diarrhoea
Tree Number: T10.8.6.3.1
database_cross_reference: DO:DOID:0090110
database_cross_reference: MEDCIN:350499
database_cross_reference: MSH:C580192
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300292
database_cross_reference: OMIM:304790
database_cross_reference: RCD:X40JY
database_cross_reference: RCDAE:X40JY
database_cross_reference: SNOMEDCT_US:237618001

spinocerebellar ataxia type 1 with axonal neuropathy
type: Class
subclass of: nervous system disease
definition: A nervous system disease characterized by autosomal recessive inheritance of spinocerebellar ataxia and peripheral neuropathy that has_material_basis_in homozygosity for a mutation in the TDP1 gene on chromosome 14q32.11.
PMOID: PMO:00030168
Subclass_of: nervous system disease
Synonym: SCAN1
Synonym: SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, WITH AXONAL NEUROPATHY
Synonym: Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy
Synonym: autosomal recessive spinocerebellar ataxia with axonal neuropathy
Tree Number: T10.8.2.7
database_cross_reference: DO:DOID:0090115
database_cross_reference: MSH:C537313
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:607198
database_cross_reference: OMIM:607250

hereditary neutrophilia
type: Class
subclass of: leukocyte disease
definition: A leukocyte disease characterized by autosomal dominant inheritance of lifelong, persistent elevated neutrophil counts primarily consisting of segmented neutrophils that has_material_basis_in heterozygous mutation in the CSF3R gene on chromosome 1p34.
PMOID: PMO:00033398
Subclass_of: leukocyte disease
Synonym: Hereditary neutrophilia
Synonym: Hereditary neutrophilia (diagnosis)
Synonym: Hereditary neutrophilia (disorder)
Synonym: Hereditary neutrophilia (finding)
Synonym: NEUTROPHILIA, HEREDITARY
Synonym: Neutrophilia, Hereditary
Synonym: neutrophilia hereditary
Tree Number: T10.8.10.6.3
database_cross_reference: DO:DOID:0090120
database_cross_reference: MEDCIN:339662
database_cross_reference: MSH:C563010
database_cross_reference: OMIM:162830
database_cross_reference: SNM:D-4359
database_cross_reference: SNOMEDCT_US:129639005

aromatase excess syndrome
type: Class
subclass of: reproductive system disease
definition: A reproductive system disease characterized by autosomal dominant inheritance of increased extraglandular aromatization of steroids resulting in heterosexual precocity in males and isosexual precocity in females that has_material_basis_in fusion of the CYP19A1 gene with various partners, brought about by translocations and resulting in gain of function of the CYP19A1 gene.
PMOID: PMO:00029733
Subclass_of: reproductive system disease
Synonym: AEXS
Synonym: AROMATASE ACTIVITY, INCREASED
Synonym: AROMATASE EXCESS SYNDROME
Synonym: Aromatase Excess Syndrome
Synonym: Aromatase excess syndrome
Synonym: Aromatase excess syndrome (disorder)
Synonym: Familial gynecomastia, due to increased aromatase activity
Synonym: GYNECOMASTIA, FAMILIAL, DUE TO INCREASED AROMATASE ACTIVITY
Synonym: GYNECOMASTIA, HEREDITARY
Synonym: Gynecomastia, Familial, due to Increased Aromatase Activity
Tree Number: T10.8.1.1
database_cross_reference: DO:DOID:0090122
database_cross_reference: MSH:C000591739
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:107910
database_cross_reference: OMIM:139300
database_cross_reference: SNOMEDCT_US:709075008

aromatic L-amino acid decarboxylase deficiency
type: Class
subclass of: inherited metabolic disorder
PMOID: PMO:00028995
Subclass_of: inherited metabolic disorder
Synonym: AADC DEFICIENCY
Synonym: Arom amino acid decarboxyl def
Synonym: Aromatic L-amino acid decarboxylase deficiency
Synonym: Aromatic amino acid decarboxylase deficiency
Synonym: Aromatic amino acid decarboxylase deficiency (disorder)
Synonym: DDC DEFICIENCY
Synonym: DOPA DECARBOXYLASE DEFICIENCY
Synonym: Dopa decarboxylase deficiency
Tree Number: T10.6.2.2
database_cross_reference: MSH:C537437
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:608643
database_cross_reference: RCD:X40S5
database_cross_reference: SNOMEDCT_US:237922009

neurogenic arthrogryposis multiplex congenita
type: Class
subclass of: nervous system disease
definition: A nervous system disease characterized by congenital contractures at the elbows and knees, myopathy, absence of muscle spindles, congenital heart disease and spinal motor nueron depletion that has_material_basis_in variation in the chromosome region 5q35.
PMOID: PMO:00029888
Subclass_of: nervous system disease
Synonym: AMC neurogenic type
Synonym: AMC, NEUROGENIC TYPE
Synonym: AMC, neurogenic type
Synonym: AMCN
Synonym: ARTHROGRYPOSIS MULTIPLEX CONGENITA, NEUROGENIC TYPE
Synonym: ARTHROGRYPOSIS MULTIPLEX CONGENITA, NEUROGENIC TYPE (disorder)
Synonym: Arthrogryposis Multiplex Congenita, Neurogenic Type
Synonym: Arthrogryposis multiplex congenita neurogenic type
Synonym: Neurogenic arthrogryposis multiplex congenita
Synonym: Neurogenic arthrogryposis multiplex congenita (disorder)
Tree Number: T10.8.2.3
database_cross_reference: DO:DOID:0090124
database_cross_reference: MSH:C536614
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:208100
database_cross_reference: SNOMEDCT_US:715316005

carnitine palmitoyltransferase I deficiency
type: Class
subclass of: lipid metabolism disorder
definition: A lipid metabolism disorder characterized by autosomal recessive inheritance of impaired mitochondrial oxidation of long chain fatty acids in the liver and kidneys resulting in episodes of illness- or fasting-induced hypoketotic hypoglycemia that has_material_basis_in homozygous or compound heterozygous mutation in the CPT1A gene on chromosome 11q13.
PMOID: PMO:00029282
Subclass_of: lipid metabolism disorder
Synonym: CARNITINE PALMITOYLTRANSFERASE I DEFICIENCY
Synonym: CARNITINE PALMITOYLTRANSFERASE IA DEFICIENCY
Synonym: CPT 1A Deficiency
Synonym: CPT DEFICIENCY, HEPATIC, TYPE I
Synonym: CPT Deficiency, Hepatic, Type I
Synonym: CPT I DEFICIENCY
Synonym: CPT I Deficiency
Synonym: CPT I deficiency
Synonym: CPT-Ia
Synonym: CPT1 - Carnitine palmitoyltransferase I deficiency
Tree Number: T10.6.2.18.13
database_cross_reference: DO:DOID:0090129
database_cross_reference: LNC:LA12485-1
database_cross_reference: LNC:LP56785-6
database_cross_reference: LNC:MTHU021615
database_cross_reference: MEDCIN:312720
database_cross_reference: MSH:C535588
database_cross_reference: NCI:C98871
database_cross_reference: NCI_NICHD:C98871
database_cross_reference: OMIM:255120
database_cross_reference: OMIM:600528
database_cross_reference: RCD:X40UQ
database_cross_reference: SNOMEDCT_US:238001003

cortisone reductase deficiency
type: Class
subclass of: endocrine system disease
definition: An endocrine system disease characterized by failure to regenerate the active glucocorticoid cortisol from cortisone resulting in adrenal hyperandrogenism.
PMOID: PMO:00033243
Subclass_of: endocrine system disease
Synonym: 11-beta-hydroxysteroid dehydrogenase, type i, deficiency of
Synonym: CORTRD
Synonym: Cortisone reductase deficiency
Synonym: Deficiency of (R)-20-hydroxysteroid dehydrogenase
Synonym: Deficiency of (R)-20-hydroxysteroid dehydrogenase (disorder)
Synonym: Deficiency of cortisone reductase
Tree Number: T10.8.8.7
database_cross_reference: DO:DOID:0090139
database_cross_reference: MSH:C536447
database_cross_reference: SNOMEDCT_US:124138004

cortisone reductase deficiency 2
type: Class
subclass of: cortisone reductase deficiency
definition: A cortisone reductase deficiency that has_material_basis_in heterozygous mutation in the HSD11B1 gene on chromosome 1q32.
PMOID: PMO:00033245
Subclass_of: cortisone reductase deficiency
Synonym: CORTISONE REDUCTASE DEFICIENCY 2
Synonym: CORTRD2
Tree Number: T10.8.8.7.2
database_cross_reference: DO:DOID:0090140
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:600713
database_cross_reference: OMIM:614662

cortisone reductase deficiency 1
type: Class
subclass of: cortisone reductase deficiency
definition: A cortisone reductase deficiency that has_material_basis_in homozygous or compound heterozygous mutation in the H6PD gene on chromosome 1p36.
PMOID: PMO:00033244
Subclass_of: cortisone reductase deficiency
Synonym: CORTISONE REDUCTASE DEFICIENCY 1
Synonym: CORTRD1
Tree Number: T10.8.8.7.1
database_cross_reference: DO:DOID:0090141
database_cross_reference: OMIM:138090
database_cross_reference: OMIM:604931

cystathioninuria
type: Class
subclass of: amino acid metabolic disorder
PMOID: PMO:00029193
Subclass_of: amino acid metabolic disorder
Synonym: Cystathione gamma-lyase defic
Synonym: Cystathione gamma-lyase deficiency
Synonym: Cystathione gamma-lyase deficiency (disorder)
Synonym: Cystathione gamma-lyase deficiency [Ambiguous]
Synonym: Cystathionine gamma-lyase deficiency
Synonym: Cystathionine gamma-lyase deficiency (disorder)
Synonym: Cystathioninuria
Synonym: Deficiency of cystathionase
Synonym: Deficiency of cystathionine gamma-lyase
Synonym: Deficiency of cystathionine gamma-lyase (disorder)
Tree Number: T10.6.2.15.15
database_cross_reference: CSP:1849-0342
database_cross_reference: CSP:4001-0049
database_cross_reference: MSH:C535408
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:C3041
database_cross_reference: SNMI:D6-B4130
database_cross_reference: SNOMEDCT_US:124632004
database_cross_reference: SNOMEDCT_US:190707005
database_cross_reference: SNOMEDCT_US:367036006
database_cross_reference: SNOMEDCT_US:6885006

dopamine beta-hydroxylase deficiency
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder characterized by decreased beta-hydroxylation of dopamine in nerves resulting in impaired autonomic noradrenergic neurotransmission and clinical features including severely decreased norepinephrine levels, orthostatic hypotension, ptosis, nasal stuffiness, and delayed eye opening that has_material_basis_in homozygous or compound heterozygous mutation in the DBH gene on chromosome 9q34.
PMOID: PMO:00029117
Subclass_of: inherited metabolic disorder
Synonym: Congenital dopamine beta hydroxylase deficiency
Synonym: DOPAMINE BETA-HYDROXYLASE DEFICIENCY
Synonym: DOPAMINE BETA-HYDROXYLASE DEFICIENCY, CONGENITAL
Synonym: Dopamine beta Hydroxylase Deficiency, Congenital
Synonym: Dopamine beta-hydroxylase def
Synonym: Dopamine beta-hydroxylase deficiency
Synonym: Dopamine beta-hydroxylase deficiency (disorder)
Synonym: NORADRENALINE DEFICIENCY
Synonym: NOREPINEPHRINE DEFICIENCY
Synonym: Noradrenaline deficiency
Tree Number: T10.6.2.10
database_cross_reference: DO:DOID:0090145
database_cross_reference: MSH:C535600
database_cross_reference: OMIM:223360
database_cross_reference: OMIM:609312
database_cross_reference: RCD:X40S6
database_cross_reference: SNOMEDCT_US:237923004

advanced sleep phase syndrome 1
type: Class
subclass of: advanced sleep phase syndrome
definition: An advanced sleep phase syndrome that has material basis in heterozygous mutation in the PER2 gene on chromosome 2q37.
PMOID: PMO:00027886
Subclass_of: advanced sleep phase syndrome
Synonym: ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1
Synonym: FASPS1
Synonym: familial advanced sleep phase syndrome 1
Tree Number: T10.3.1.2.2
database_cross_reference: DO:DOID:0110011
database_cross_reference: OMIM:603426
database_cross_reference: OMIM:604348

advanced sleep phase syndrome 2
type: Class
subclass of: advanced sleep phase syndrome
definition: An advanced sleep phase syndrome that has material basis in heterozygous mutation in the CSNK1D gene on chromosome 17q25.
PMOID: PMO:00027885
Subclass_of: advanced sleep phase syndrome
Synonym: ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 2
Synonym: FASPS2
Synonym: familial advanced sleep phase syndrome 2
Tree Number: T10.3.1.2.1
database_cross_reference: DO:DOID:0110012
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:600864
database_cross_reference: OMIM:615224

advanced sleep phase syndrome 3
type: Class
subclass of: advanced sleep phase syndrome
definition: An advanced sleep phase syndrome that has material basis in heterozygous mutation in the PER3 gene on chromosome 1p36.23.
PMOID: PMO:00027887
Subclass_of: advanced sleep phase syndrome
Synonym: ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 3
Synonym: FASPS3
Synonym: familial advanced sleep phase syndrome 3
Tree Number: T10.3.1.2.3
database_cross_reference: DO:DOID:0110013
database_cross_reference: OMIM:616882

autosomal dominant Alport syndrome
type: Class
subclass of: Alport syndrome
definition: An Alport syndrome that has_material -basis_in heterozygous mutation in the COL4A3 gene.
PMOID: PMO:00028388
Subclass_of: Alport syndrome
Synonym: ALPORT SYNDROME, AUTOSOMAL DOMINANT
Synonym: Alport Syndrome, Autosomal Dominant
Synonym: Alport syndrome autosomal dominant
Synonym: Alport syndrome autosomal dominant (disorder)
Synonym: alport's syndrome autosomal dominant
Synonym: alport's syndrome autosomal dominant (diagnosis)
Tree Number: T10.5.3.1.1
database_cross_reference: DO:DOID:0110032
database_cross_reference: MEDCIN:362100
database_cross_reference: MSH:D009394
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:104200
database_cross_reference: OMIM:120070
database_cross_reference: SNOMEDCT_US:717766000

autosomal recessive Alport syndrome
type: Class
subclass of: Alport syndrome
definition: An Alport syndrome that has_material -basis_in homozygous or compound heterozygous mutation in the COL4A3 or the COL4A4 gene, both of which map to chromosome 2q
PMOID: PMO:00028390
Subclass_of: Alport syndrome
Synonym: ALPORT SYNDROME, AUTOSOMAL RECESSIVE
Synonym: Alport Syndrome, Autosomal Recessive
Synonym: Alport syndrome autosomal recessive
Synonym: Alport syndrome autosomal recessive (disorder)
Synonym: alport's syndrome autosomal recessive
Synonym: alport's syndrome autosomal recessive (diagnosis)
Tree Number: T10.5.3.1.3
database_cross_reference: DO:DOID:0110033
database_cross_reference: MEDCIN:362101
database_cross_reference: MSH:D009394
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:120070
database_cross_reference: OMIM:120131
database_cross_reference: OMIM:203780
database_cross_reference: SNOMEDCT_US:717767009

X-linked Alport syndrome
type: Class
subclass of: Alport syndrome
definition: An Alport syndrome that has material basis in mutation in the gene encoding the alpha-5 chain of basement membrane collagen type IV (COL4A5).
PMOID: PMO:00028389
Subclass_of: Alport syndrome
Synonym: ALPORT SYNDROME, X-LINKED
Synonym: ATS
Synonym: Alport Syndrome, X Linked
Synonym: Alport Syndrome, X-Linked
Synonym: Alport syndrome X-linked
Synonym: Alport syndrome X-linked (disorder)
Synonym: NEPHROPATHY AND DEAFNESS, X-LINKED
Synonym: X-Linked Alport Syndrome
Synonym: alport's syndrome x-linked
Synonym: alport's syndrome x-linked (diagnosis)
Tree Number: T10.5.3.1.2
database_cross_reference: DO:DOID:0110034
database_cross_reference: MEDCIN:362102
database_cross_reference: MSH:D009394
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:301050
database_cross_reference: OMIM:303630
database_cross_reference: SNOMEDCT_US:717768004

isolated cleft palate
type: Class
subclass of: cleft palate
definition: A cleft palate seen as an isolated malformation, distinct from cleft lip with or without cleft palate
PMOID: PMO:00028287
Subclass_of: cleft palate
Synonym: CLEFT PALATE
Synonym: CLEFT PALATE, ISOLATED
Synonym: CP
Synonym: CPI
Synonym: Cleft Palate, Isolated
Synonym: Cleft palate, isolated
Tree Number: T10.4.21.1.2
database_cross_reference: DO:DOID:0110213
database_cross_reference: MSH:D002972
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:119540
database_cross_reference: OMIM:MTHU001581

cleft soft palate
type: Class
subclass of: cleft palate
definition: Cleft velum is a fissure type embryopathy that affects in varying degrees the soft palate.
PMOID: PMO:00028286
Subclass_of: cleft palate
Synonym: CLEFT SOFT PALATE
Synonym: Cleft Soft Palate
Synonym: Cleft muscular palate
Synonym: Cleft of soft palate
Synonym: Cleft of soft palate (diagnosis)
Synonym: Cleft of soft palate (disorder)
Synonym: Cleft of soft palate only
Synonym: Cleft palate (soft)
Synonym: Cleft soft palate
Synonym: Cleft soft palate NOS
Tree Number: T10.4.21.1.1
database_cross_reference: CHV:0000034180
database_cross_reference: DO:DOID:0110214
database_cross_reference: HPO:HP:0000185
database_cross_reference: ICD10:Q35.3
database_cross_reference: ICD10AM:Q35.3
database_cross_reference: ICD10CM:Q35.3
database_cross_reference: MDR:10009270
database_cross_reference: MEDCIN:290349
database_cross_reference: MEDCIN:360170
database_cross_reference: MSH:C562950
database_cross_reference: OMIM:119570
database_cross_reference: OMIM:MTHU003778
database_cross_reference: RCD:X788U
database_cross_reference: RCD:X788V
database_cross_reference: SNOMEDCT_US:204599008
database_cross_reference: SNOMEDCT_US:204601005
database_cross_reference: SNOMEDCT_US:253997002
database_cross_reference: SNOMEDCT_US:253998007
database_cross_reference: SNOMEDCT_US:253999004

primary ciliary dyskinesia 1
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by sinusitis, bronchiectasis and situs inversus with dextrocardia resulting from dysfunction of the cilia during embryologic development.
PMOID: PMO:00028343
Subclass_of: primary ciliary dyskinesia
Synonym: Bronchiectasis, Polynesian
Synonym: Bronchiectasis, chronic sinusitis AND dextrocardia syndrome
Synonym: Bronchiectasis, chronic sinusitis and dextrocardia syndrome
Synonym: Bronchiectasis-chronic sinusitis and dextrocardia syndrome
Synonym: CILD1
Synonym: Ciliary Dyskinesia, Primary
Synonym: DEXTROCARDIA, BRONCHIECTASIS, AND SINUSITIS
Synonym: DEXTROCARDIA-BRONCHIECTASIS-SINUSITIS SYNDROME
Synonym: Dextrocardia, Bronchiectasis, and Sinusitis
Synonym: Dyskinesia, Primary Ciliary
Tree Number: T10.5.1.3.9
database_cross_reference: CCPSS:0047908
database_cross_reference: CHV:0000007042
database_cross_reference: DO:DOID:0050144
database_cross_reference: DO:DOID:0110594
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000964
database_cross_reference: MDR:10023299
database_cross_reference: MEDCIN:33028
database_cross_reference: MSH:D007619
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84797
database_cross_reference: NDFRT:N0000001731
database_cross_reference: OMIM:244400
database_cross_reference: RCD:PK35.
database_cross_reference: RCD:X101Z
database_cross_reference: SNM:D-7719
database_cross_reference: SNMI:D4-01516
database_cross_reference: SNOMEDCT_US:42402006
database_cross_reference: SNOMEDCT_US:86204009

Stromme syndrome
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance and ciliopathy with some type of intestinal atresia, variable ocular abnormalities, microcephaly, and has_material_basis_in compound heterozygous mutation in the CENPF gene on chromosome 1q41.
PMOID: PMO:00028345
Subclass_of: primary ciliary dyskinesia
Synonym: CILD31
Synonym: Oth congenital malformation syndromes, NEC
Synonym: Other specified congenital malformation syndromes, not elsewhere classified
Synonym: Other specified congenital malformation syndromes, not elsewhere classified in ICD10CM
Synonym: apple peel syndrome with microcephaly and ocular anomalies
Synonym: jejunal atresia with microcephaly and ocular anomalies
Synonym: lethal fetal brain malformation-duodenal atresia-bilateral renal hypoplasia syndrome
Synonym: primary ciliary dyskinesia 31
Tree Number: T10.5.1.3.11
database_cross_reference: DO:DOID:0110595
database_cross_reference: ICD10:Q87.8
database_cross_reference: ICD10AM:Q87.8
database_cross_reference: ICD10CM:Q87.8
database_cross_reference: ICD10CM:Q87.89
database_cross_reference: MTH:NOCODE

primary ciliary dyskinesia 21
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with a missing Nexin link, infantile onset of chronic sinopulmonary infections, and has_material_basis_in homozygous mutation in the DRC1 gene on chromosome 2p23.
PMOID: PMO:00028352
Subclass_of: primary ciliary dyskinesia
Synonym: CILD21
Synonym: CILIARY DYSKINESIA, PRIMARY, 21
Synonym: CILIARY DYSKINESIA, PRIMARY, 21, WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 21 without situs inversus
Tree Number: T10.5.1.3.18
database_cross_reference: DO:DOID:0110596
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:615288
database_cross_reference: OMIM:615294

primary ciliary dyskinesia 22
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer and inner dynein arm defect, recurrent respiratory infections, persistent rhinosinusitis, otitis media, chronic cough, variable presence of situs abnormalities, and has_material_basis_in homozygous or compound heterozygous mutation in the ZMYND10 gene on chromosome 3p21.
PMOID: PMO:00028353
Subclass_of: primary ciliary dyskinesia
Synonym: CILD22
Synonym: CILIARY DYSKINESIA, PRIMARY, 22
Synonym: CILIARY DYSKINESIA, PRIMARY, 22, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 22 with or without situs inversus
Tree Number: T10.5.1.3.19
database_cross_reference: DO:DOID:0110597
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:607070
database_cross_reference: OMIM:615444

primary ciliary dyskinesia 14
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with inner dynein arm defect and axonemal disorganization, chronic upper and lower airway infections, and has_material_basis_in homozygous or compound heterozygous mutation in the CCDC39 gene on chromosome 3q26.
PMOID: PMO:00028368
Subclass_of: primary ciliary dyskinesia
Synonym: CILD14
Synonym: CILIARY DYSKINESIA, PRIMARY, 14
Synonym: CILIARY DYSKINESIA, PRIMARY, 14, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 14 with or without situs inversus
Tree Number: T10.5.1.3.34
database_cross_reference: DO:DOID:0110598
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:613798
database_cross_reference: OMIM:613807

primary ciliary dyskinesia 3
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer dynein arm defect, ciliary akinesia and variable occurence of situs inversus and has_material_basis_in homozygous or compound heterozygous mutation in the DNAH5 gene on chromosome 5p15.
PMOID: PMO:00028341
Subclass_of: primary ciliary dyskinesia
Synonym: CILD3
Synonym: CILIARY DYSKINESIA, PRIMARY, 3
Synonym: CILIARY DYSKINESIA, PRIMARY, 3, WITH OR WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 3
Synonym: Ciliary Dyskinesia, Primary, 3, with or without Situs Inversus
Synonym: Primary ciliary dyskinesia, 3
Synonym: primary ciliary dyskinesia 3 with or without situs inversus
Tree Number: T10.5.1.3.7
database_cross_reference: DO:DOID:0110599
database_cross_reference: MSH:C535278
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:603335
database_cross_reference: OMIM:608644

primary ciliary dyskinesia 29
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with oligocilia and early childhood onset of recurrent respiratory infections, and has_material_basis_in homozygous or compound heterozygous mutation in the CCNO gene on chromosome 5p15.
PMOID: PMO:00028355
Subclass_of: primary ciliary dyskinesia
Synonym: CILD29
Synonym: CILIARY DYSKINESIA, PRIMARY, 29
Synonym: CILIARY DYSKINESIA, PRIMARY, 29, WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 29 without situs inversus
Tree Number: T10.5.1.3.21
database_cross_reference: DO:DOID:0110600
database_cross_reference: OMIM:607752
database_cross_reference: OMIM:615872

primary ciliary dyskinesia 12
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by reduced exercise tolerance, chronic wet cough, recurrent respiratory infections, bronchiectasis, and nasal symptoms, and has_material_basis_in homozygous mutation in the RSPH9 gene on chromosome 6p21.
PMOID: PMO:00028370
Subclass_of: primary ciliary dyskinesia
Synonym: CILD12
Synonym: CILIARY DYSKINESIA, PRIMARY, 12
Synonym: CILIARY DYSKINESIA, PRIMARY, 12, WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 12
Synonym: primary ciliary dyskinesia 12 without situs inversus
Tree Number: T10.5.1.3.36
database_cross_reference: DO:DOID:0110601
database_cross_reference: MSH:C567211
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:612648
database_cross_reference: OMIM:612650

primary ciliary dyskinesia 11
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by reduced exercise tolerance, chronic wet cough, recurrent respiratory infections, bronchiectasis, nasal symptoms, ear obstruction with consequent hearing problems, low weight, and short stature, and has_material_basis_in homozygous or compound heterozygous mutation in the RSPH4A gene on chromosome 6q22.
PMOID: PMO:00028363
Subclass_of: primary ciliary dyskinesia
Synonym: CILD11
Synonym: CILIARY DYSKINESIA, PRIMARY, 11
Synonym: CILIARY DYSKINESIA, PRIMARY, 11, WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 11
Synonym: primary ciliary dyskinesia 11 without situs inversus
Tree Number: T10.5.1.3.29
database_cross_reference: DO:DOID:0110602
database_cross_reference: MSH:C567212
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:612647
database_cross_reference: OMIM:612649

primary ciliary dyskinesia 32
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with near absence of radial spokes, respiratory distress in term neonates, impaired mucociliary clearance, chronic respiratory infections, bronchiectasis, and infertility and has_material_basis_in homozygous or compound heterozygous mutation in the RSPH3 gene on chromosome 6q25.
PMOID: PMO:00028346
Subclass_of: primary ciliary dyskinesia
Synonym: CILD32
Synonym: CILIARY DYSKINESIA, PRIMARY, 32
Synonym: CILIARY DYSKINESIA, PRIMARY, 32, WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 32 without situs inversus
Tree Number: T10.5.1.3.12
database_cross_reference: DO:DOID:0110603
database_cross_reference: OMIM:615876
database_cross_reference: OMIM:616481

primary ciliary dyskinesia 18
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer and inner dynein arm defect, early infantile onset of recurrent sinopulmonary infections, male infertility, and variable occurence of situs inversus and has_material_basis_in homozygous mutation in the HEATR2 gene on chromosome 7p22.
PMOID: PMO:00028364
Subclass_of: primary ciliary dyskinesia
Synonym: CILD18
Synonym: CILIARY DYSKINESIA, PRIMARY, 18
Synonym: CILIARY DYSKINESIA, PRIMARY, 18, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 18 with or without situs inversus
Tree Number: T10.5.1.3.30
database_cross_reference: DO:DOID:0110604
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:614864
database_cross_reference: OMIM:614874

primary ciliary dyskinesia 7
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with chronic respiratory infections, chronic sinusitis, recurrent bronchitis, and pneumonia beginning in infancy or early childhood and has_material_basis_in mutation in the DNAH11 gene on chromosome 7p21.
PMOID: PMO:00028337
Subclass_of: primary ciliary dyskinesia
Synonym: CILD7
Synonym: CILIARY DYSKINESIA, PRIMARY, 7
Synonym: CILIARY DYSKINESIA, PRIMARY, 7 (disorder)
Synonym: CILIARY DYSKINESIA, PRIMARY, 7, WITH OR WITHOUT SITUS INVERSUS
Synonym: Cild7
Synonym: Ciliary Dyskinesia, Primary, 7
Synonym: Ciliary Dyskinesia, Primary, 7, With Or Without Situs Inversus
Synonym: primary ciliary dyskinesia 7 with or without situs inversus
Tree Number: T10.5.1.3.3
database_cross_reference: DO:DOID:0110605
database_cross_reference: MSH:C567504
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:603339
database_cross_reference: OMIM:611884

primary ciliary dyskinesia 6
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by partial outer dynein arm defect and has_material_basis_in mutation in the TXNDC3 gene on the chromosome 7p14.1.
PMOID: PMO:00028340
Subclass_of: primary ciliary dyskinesia
Synonym: CILD6
Synonym: CILIARY DYSKINESIA, PRIMARY, 6
Synonym: Ciliary Dyskinesia, Primary, 6
Tree Number: T10.5.1.3.6
database_cross_reference: DO:DOID:0110606
database_cross_reference: MSH:C567057
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:607421
database_cross_reference: OMIM:610852

primary ciliary dyskinesia 28
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer and inner dynein arm defect, recurrent upper and lower airway disease, bronchiectasis, and decreased fertility and has_material_basis_in homozygous or compound heterozygous mutation in the SPAG1 gene on chromosome 8q22.
PMOID: PMO:00028357
Subclass_of: primary ciliary dyskinesia
Synonym: CILD28
Synonym: CILIARY DYSKINESIA, PRIMARY, 28
Synonym: CILIARY DYSKINESIA, PRIMARY, 28, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 28 with or without situs inversus
Tree Number: T10.5.1.3.23
database_cross_reference: DO:DOID:0110607
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:603395
database_cross_reference: OMIM:615505

primary ciliary dyskinesia 19
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer and inner dynein arm defect, chronic sinopulmonary infections, asthenospermia, and immotile cilia and has_material_basis_in homozygous mutation in the LRRC6 on chromosome 8q24.
PMOID: PMO:00028365
Subclass_of: primary ciliary dyskinesia
Synonym: CILD19
Synonym: CILIARY DYSKINESIA, PRIMARY, 19
Synonym: CILIARY DYSKINESIA, PRIMARY, 19, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 19 with or without situs inversus
Tree Number: T10.5.1.3.31
database_cross_reference: DO:DOID:0110608
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:614930
database_cross_reference: OMIM:614935

primary ciliary dyskinesia 23
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer dynein arm defect, respiratory distress and recurrent upper and lower airway infections, and variable occurence of situs inversus and has_material_basis_in homozygous or compound heterozygous mutation in the ARMC4 gene on chromosome 10p.
PMOID: PMO:00028360
Subclass_of: primary ciliary dyskinesia
Synonym: CILD23
Synonym: CILIARY DYSKINESIA, PRIMARY, 23
Synonym: CILIARY DYSKINESIA, PRIMARY, 23, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 23 with or without situs inversus
Tree Number: T10.5.1.3.26
database_cross_reference: DO:DOID:0110609
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:615408
database_cross_reference: OMIM:615451

primary ciliary dyskinesia 34
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with childhood onset of recurrent sinopulmonary infections and male infertility and has_material_basis_in homozygous mutation in the DNAJB13 gene on chromosome 11q13.
PMOID: PMO:00028350
Subclass_of: primary ciliary dyskinesia
Synonym: CILD34
Synonym: CILIARY DYSKINESIA, PRIMARY, 34
Synonym: CILIARY DYSKINESIA, PRIMARY, 34, WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 34 without situs inversus
Tree Number: T10.5.1.3.16
database_cross_reference: DO:DOID:0110610
database_cross_reference: OMIM:610263
database_cross_reference: OMIM:617091

primary ciliary dyskinesia 27
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with neonatal respiratory distress, recurrent upper and lower airway disease, and bronchiectasis and has_material_basis_in homozygous mutation in the CCDC65 gene on chromosome 12q13.
PMOID: PMO:00028356
Subclass_of: primary ciliary dyskinesia
Synonym: CILD27
Synonym: CILIARY DYSKINESIA, PRIMARY, 27
Synonym: CILIARY DYSKINESIA, PRIMARY, 27, WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 27 without situs inversus
Tree Number: T10.5.1.3.22
database_cross_reference: DO:DOID:0110611
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:611088
database_cross_reference: OMIM:615504

primary ciliary dyskinesia 10
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by outer and inner dynein arm absence, chronic otitis media, sinusitis, recurrent pneumonia and variable occurrence of situs inversus and has_material_basis_in homozygous mutation in the KTU gene on chromosome 14q21.
PMOID: PMO:00028362
Subclass_of: primary ciliary dyskinesia
Synonym: CILD10
Synonym: CILIARY DYSKINESIA, PRIMARY, 10
Synonym: CILIARY DYSKINESIA, PRIMARY, 10, WITH OR WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 10
Synonym: primary ciliary dyskinesia 10 with or without situs inversus
Tree Number: T10.5.1.3.28
database_cross_reference: DO:DOID:0110612
database_cross_reference: MSH:C567287
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:612517
database_cross_reference: OMIM:612518

primary ciliary dyskinesia 16
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with absence of ciliary outer dynein arms, early infantile onset of respiratory distress, and variable occurrence of situs inversus and has_material_basis_in homozygous mutation in the DNAL1 gene on chromosome 14q24.3.
PMOID: PMO:00028366
Subclass_of: primary ciliary dyskinesia
Synonym: CILD16
Synonym: CILIARY DYSKINESIA, PRIMARY, 16
Synonym: CILIARY DYSKINESIA, PRIMARY, 16, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 16 with or without situs inversus
Tree Number: T10.5.1.3.32
database_cross_reference: DO:DOID:0110613
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:610062
database_cross_reference: OMIM:614017

primary ciliary dyskinesia 4
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by partial absence of the inner dynein arms with variable occurrence of situs inversus and has_material_basis_in variation in the chromosome region 15q13.1-q15.1.
PMOID: PMO:00028342
Subclass_of: primary ciliary dyskinesia
Synonym: CILD4
Synonym: CILIARY DYSKINESIA, PRIMARY, 4
Synonym: CILIARY DYSKINESIA, PRIMARY, 4, WITH OR WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 4
Synonym: Ciliary Dyskinesia, Primary, 4, with or without Situs Inversus
Synonym: Primary ciliary dyskinesia, 4
Synonym: primary ciliary dyskinesia 4 with or without situs inversus
Tree Number: T10.5.1.3.8
database_cross_reference: DO:DOID:0110614
database_cross_reference: MSH:C535279
database_cross_reference: OMIM:608646

primary ciliary dyskinesia 25
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with inner and outer dynein arm defect, recurrent upper and lower airway disease, bronchiectasis, decreased fertility and variable occurence of laterality defects and has_material_basis_in homozygous or compound heterozygous mutation in the DYX1C1 gene on chromosome 15q21.
PMOID: PMO:00028358
Subclass_of: primary ciliary dyskinesia
Synonym: CILD25
Synonym: CILIARY DYSKINESIA, PRIMARY, 25
Synonym: CILIARY DYSKINESIA, PRIMARY, 25, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 25 with or without situs inversus
Tree Number: T10.5.1.3.24
database_cross_reference: DO:DOID:0110615
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:608706
database_cross_reference: OMIM:615482

primary ciliary dyskinesia 8
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that has_material_basis_in variation in the chromosome region 15q24-q25.
PMOID: PMO:00028338
Subclass_of: primary ciliary dyskinesia
Synonym: CILD8
Synonym: CILIARY DYSKINESIA, PRIMARY, 8
Synonym: CILIARY DYSKINESIA, PRIMARY, 8, WITH OR WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 8
Synonym: Ciliary Dyskinesia, Primary, 8, With Or Without Situs Inversus
Synonym: primary ciliary dyskinesia 8 with or without situs inversus
Tree Number: T10.5.1.3.4
database_cross_reference: DO:DOID:0110616
database_cross_reference: MSH:C567373
database_cross_reference: OMIM:612274

primary ciliary dyskinesia 5
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with early onset of a progressive decline in lung function and has_material_basis_in homozygous mutation in the HYDIN gene on chromosome 16q22.
PMOID: PMO:00028339
Subclass_of: primary ciliary dyskinesia
Synonym: CILD5
Synonym: CILIARY DYSKINESIA, PRIMARY, 5
Synonym: CILIARY DYSKINESIA, PRIMARY, 5, WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 5
Synonym: Ciliary Dyskinesia, Primary, 5, with or without Situs Inversus
Synonym: primary ciliary dyskinesia 5 without situs inversus
Tree Number: T10.5.1.3.5
database_cross_reference: DO:DOID:0110617
database_cross_reference: MSH:C563886
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:608647
database_cross_reference: OMIM:610812

primary ciliary dyskinesia 13
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by inner and outer dynein arm defect, immotile cilia, and variable occurence of laterality defects and has_material_basis_in homozygous or compound heterozygous mutation in the LRRC50 gene on chromosome 16q23-q24.
PMOID: PMO:00028371
Subclass_of: primary ciliary dyskinesia
Synonym: CILD13
Synonym: CILIARY DYSKINESIA, PRIMARY, 13
Synonym: CILIARY DYSKINESIA, PRIMARY, 13, WITH OR WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 13
Synonym: Ciliary Dyskinesia, Primary, 13, With Or Without Situs Inversus
Synonym: primary ciliary dyskinesia 13 with or without situs inversus
Tree Number: T10.5.1.3.37
database_cross_reference: DO:DOID:0110618
database_cross_reference: MSH:C567713
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:613190
database_cross_reference: OMIM:613193

primary ciliary dyskinesia 33
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with recurrent upper and lower respiratory infections and has_material_basis_in homozygous mutation in the GAS8 gene on chromosome 16q24.
PMOID: PMO:00028347
Subclass_of: primary ciliary dyskinesia
Synonym: CILD33
Synonym: CILIARY DYSKINESIA, PRIMARY, 33
Synonym: CILIARY DYSKINESIA, PRIMARY, 33, WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 33 without situs inversus
Tree Number: T10.5.1.3.13
database_cross_reference: DO:DOID:0110619
database_cross_reference: OMIM:605178
database_cross_reference: OMIM:616726

primary ciliary dyskinesia 35
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with absent outer dynein arms, immotile cilia, variable occurence of laterality defects and recurrent upper and lower respiratory infections and has_material_basis_in homozygous mutation in the TTC25 gene on chromosome 17q21.
PMOID: PMO:00028351
Subclass_of: primary ciliary dyskinesia
Synonym: CILD35
Synonym: CILIARY DYSKINESIA, PRIMARY, 35
Synonym: CILIARY DYSKINESIA, PRIMARY, 35, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 35 with or without situs inversus
Tree Number: T10.5.1.3.17
database_cross_reference: DO:DOID:0110620
database_cross_reference: OMIM:617092
database_cross_reference: OMIM:617095

primary ciliary dyskinesia 17
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with inner and outer dynein arm defect, early infantile onset of respiratory distress, and variable occurence of laterality defects and has_material_basis_in homozygous mutation in the CCDC103 gene on chromosome 17q21.
PMOID: PMO:00028367
Subclass_of: primary ciliary dyskinesia
Synonym: CILD17
Synonym: CILIARY DYSKINESIA, PRIMARY, 17
Synonym: CILIARY DYSKINESIA, PRIMARY, 17, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 17 with or without situs inversus
Tree Number: T10.5.1.3.33
database_cross_reference: DO:DOID:0110621
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:614677
database_cross_reference: OMIM:614679

primary ciliary dyskinesia 9
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer dynein arm defect, neonatal respiratory distress, sinusitis, otitis, bronchiectasis, and variable occurence of laterality defects and has_material_basis_in homozygous mutation in the DNAI2 gene on chromosome 17q25.
PMOID: PMO:00028336
Subclass_of: primary ciliary dyskinesia
Synonym: CILD9
Synonym: CILIARY DYSKINESIA, PRIMARY, 9
Synonym: CILIARY DYSKINESIA, PRIMARY, 9, WITH OR WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 9
Synonym: Ciliary Dyskinesia, Primary, 9, With Or Without Situs Inversus
Synonym: primary ciliary dyskinesia 9 with or without situs inversus
Tree Number: T10.5.1.3.2
database_cross_reference: DO:DOID:0110622
database_cross_reference: MSH:C567310
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:605483
database_cross_reference: OMIM:612444

primary ciliary dyskinesia 15
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with inner dynein arm defect, axonemal disorganization, recurrent respiratory infections and has_material_basis_in homozygous or compound heterozygous mutation in the CCDC40 gene on chromosome 17q25.
PMOID: PMO:00028369
Subclass_of: primary ciliary dyskinesia
Synonym: CILD15
Synonym: CILIARY DYSKINESIA, PRIMARY, 15
Synonym: CILIARY DYSKINESIA, PRIMARY, 15, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 15 with or without situs inversus
Tree Number: T10.5.1.3.35
database_cross_reference: DO:DOID:0110623
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:613799
database_cross_reference: OMIM:613808

primary ciliary dyskinesia 30
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer dynein arm defect, recurrent upper and lower airway disease, bronchiectasis, nasal blockages, polyps, otitis media, and variable occurence of laterality defects and has_material_basis_in homozygous mutation in the CCDC151 gene on chromosome 19p13.
PMOID: PMO:00028348
Subclass_of: primary ciliary dyskinesia
Synonym: CILD30
Synonym: CILIARY DYSKINESIA, PRIMARY, 30
Synonym: CILIARY DYSKINESIA, PRIMARY, 30, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 30 without situs inversus
Tree Number: T10.5.1.3.14
database_cross_reference: DO:DOID:0110624
database_cross_reference: OMIM:615956
database_cross_reference: OMIM:616037

primary ciliary dyskinesia 20
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer dynein arm defect, infantile onset of chronic sinopulmonary infections, and variable occurence of laterality defects and has_material_basis_in homozygous or compound heterozygous mutation in the CCDC114 gene on chromosome 19q13.
PMOID: PMO:00028354
Subclass_of: primary ciliary dyskinesia
Synonym: CILD20
Synonym: CILIARY DYSKINESIA, PRIMARY, 20
Synonym: CILIARY DYSKINESIA, PRIMARY, 20, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 20 with or without situs inversus
Tree Number: T10.5.1.3.20
database_cross_reference: DO:DOID:0110625
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:615038
database_cross_reference: OMIM:615067

primary ciliary dyskinesia 2
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with inner and outer dynein arm defect, otitis media, sinusitis, chronic cough, recurrent respiratory infections, and variable occurence of laterality defects and has_material_basis_in homozygous mutation in the DNAAF3 gene on chromosome 19q13.
PMOID: PMO:00028344
Subclass_of: primary ciliary dyskinesia
Synonym: CILD2
Synonym: CILIARY DYSKINESIA, PRIMARY, 2
Synonym: CILIARY DYSKINESIA, PRIMARY, 2 (disorder)
Synonym: CILIARY DYSKINESIA, PRIMARY, 2, WITH OR WITHOUT SITUS INVERSUS
Synonym: Ciliary Dyskinesia, Primary, 2
Synonym: Primary ciliary dyskinesia, 2
Synonym: primary ciliary dyskinesia 2 with or without situs inversus
Tree Number: T10.5.1.3.10
database_cross_reference: DO:DOID:0110626
database_cross_reference: MSH:C535277
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:606763
database_cross_reference: OMIM:614566

primary ciliary dyskinesia 26
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with inner and outer dynein arm defect, neonatal respiratory distress, recurrent upper and lower airway disease, bronchiectasis, and variable occurence of laterality defects and has_material_basis_in homozygous or compound heterozygous mutation in the C21ORF59 gene on chromosome 21q22.
PMOID: PMO:00028359
Subclass_of: primary ciliary dyskinesia
Synonym: CILD26
Synonym: CILIARY DYSKINESIA, PRIMARY, 26
Synonym: CILIARY DYSKINESIA, PRIMARY, 26, WITH OR WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 26 with or without situs inversus
Tree Number: T10.5.1.3.25
database_cross_reference: DO:DOID:0110627
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:615500

primary ciliary dyskinesia 24
type: Class
subclass of: primary ciliary dyskinesia
definition: A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with sinopulmonary infection and subfertility and has_material_basis_in homozygous or compound heterozygous mutation in the RSPH1 gene on chromosome 21q22.
PMOID: PMO:00028361
Subclass_of: primary ciliary dyskinesia
Synonym: CILD24
Synonym: CILIARY DYSKINESIA, PRIMARY, 24
Synonym: CILIARY DYSKINESIA, PRIMARY, 24, WITHOUT SITUS INVERSUS
Synonym: primary ciliary dyskinesia 24 without situs inversus
Tree Number: T10.5.1.3.27
database_cross_reference: DO:DOID:0110628
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:609314
database_cross_reference: OMIM:615481

Wolfram syndrome 1
type: Class
subclass of: Wolfram syndrome
definition: An autosomal recessive disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the WFS1 gene on chromosome 4p16.1.
PMOID: PMO:00025230
Subclass_of: Wolfram syndrome
Synonym: DIABETES INSIPIDUS AND MELLITUS WITH OPTIC ATROPHY AND DEAFNESS
Synonym: DIDMOAD
Synonym: DIDMOAD - Diabetes insipidus, diabetes mellitus, optic atrophy and deafness
Synonym: DIDMOAD - Diabetes insipidus,diabetes mellitus, optic atrophy and deafness
Synonym: DIDMOAD Syndrome
Synonym: DIDMOAD syndrome
Synonym: DIDMOAD-Diab insip,diab mel,optic atroph+deafness
Synonym: DIDMOADUD
Synonym: Diab ins,diab mell,opt at,deaf
Synonym: Diab insipidus,diab mell,optic atrophy and deafness
Tree Number: T10.1.93.1
database_cross_reference: CHV:0000013178
database_cross_reference: CSP:0977-5687
database_cross_reference: CSP:2042-6601
database_cross_reference: DO:DOID:0110629
database_cross_reference: DO:DOID:10632
database_cross_reference: JABL:660
database_cross_reference: MDR:10078338
database_cross_reference: MDR:10078339
database_cross_reference: MEDCIN:354152
database_cross_reference: MSH:D014929
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35133
database_cross_reference: NDFRT:N0000003167
database_cross_reference: OMIM:222300
database_cross_reference: OMIM:606201
database_cross_reference: RCD:X008t
database_cross_reference: SNM:D-X435
database_cross_reference: SNMI:DB-61790
database_cross_reference: SNOMEDCT_US:70694009

Wolfram syndrome 2
type: Class
subclass of: Wolfram syndrome
definition: An autosomal recessive neurodegenerative disorder characterized by diabetes mellitus, high frequency sensorineural hearing loss, optic atrophy or neuropathy, and defective platelet aggregation resulting in peptic ulcer bleeding. It has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the CISD2 gene on chromosome 4q24.
PMOID: PMO:00025231
Subclass_of: Wolfram syndrome
Synonym: WFS2
Synonym: WOLFRAM SYNDROME 2
Synonym: Wolfram Syndrome 2
Tree Number: T10.1.93.2
database_cross_reference: DO:DOID:0110630
database_cross_reference: MSH:C565733
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:604928
database_cross_reference: OMIM:611507

rhizomelic chondrodysplasia punctata type 1
type: Class
subclass of: rhizomelic chondrodysplasia punctata
definition: A rhizomelic chondrodysplasia punctata that has material basis in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the PEX7 gene on chromosome 6q23.3.
PMOID: PMO:00028832
Subclass_of: rhizomelic chondrodysplasia punctata
Synonym: CHONDRODYSTROPHIA CALCIFICANS PUNCTATA
Synonym: Chondrodystrophia calcificans punctata
Synonym: PBD9
Synonym: PEROXISOME BIOGENESIS DISORDER 9
Synonym: Pbd9
Synonym: Peroxisome Biogenesis Disorder 9
Synonym: RCDP1
Synonym: RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 1
Synonym: Rcdp1
Synonym: Rhizomelic chondrodysplasia punctata, type 1
Tree Number: T10.5.10.1.2
database_cross_reference: DO:DOID:0110851
database_cross_reference: MEDCIN:312734
database_cross_reference: MSH:C531651
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:215100
database_cross_reference: OMIM:601757

rhizomelic chondrodysplasia punctata type 2
type: Class
subclass of: rhizomelic chondrodysplasia punctata
definition: A rhizomelic chondrodysplasia punctata that has material basis in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the GNPAT gene on chromosome 1q42.2.
PMOID: PMO:00028833
Subclass_of: rhizomelic chondrodysplasia punctata
Synonym: CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC, DUE TO DIHYDROXYACETONEPHOSPHATE ACYLTRANSFERASE DEFICIENCY
Synonym: Chondrodysplasia Punctata, Rhizomelic, Due To Dihydroxyacetonephosphate Acyltransferase Deficiency
Synonym: Chondrodysplasia punctata, rhizomelic, due to DHAPAT deficiency
Synonym: DHAPAT DEFICIENCY
Synonym: DHAPAT deficiency
Synonym: DIHYDROXYACETONEPHOSPHATE ACYLTRANSFERASE DEFICIENCY
Synonym: Dhapat Deficiency
Synonym: Dihydroxyacetonephosphate Acyltransferase Deficiency
Synonym: Dihydroxyacetonephosphate acyltransferase deficiency
Synonym: GLYCERONEPHOSPHATE O-ACYLTRANSFERASE DEFICIENCY
Tree Number: T10.5.10.1.3
database_cross_reference: DO:DOID:0110852
database_cross_reference: MEDCIN:312735
database_cross_reference: MSH:C537607
database_cross_reference: OMIM:222765
database_cross_reference: OMIM:602744

rhizomelic chondrodysplasia punctata type 3
type: Class
subclass of: rhizomelic chondrodysplasia punctata
definition: A rhizomelic chondrodysplasia punctata that has material basis in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the AGPS gene on chromosome 2q31.2.
PMOID: PMO:00028831
Subclass_of: rhizomelic chondrodysplasia punctata
Synonym: AGPS DEFICIENCY
Synonym: AGPS deficiency
Synonym: ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE DEFICIENCY
Synonym: ALKYLGLYCERONE-PHOSPHATE SYNTHASE DEFICIENCY
Synonym: Agps Deficiency
Synonym: Alkyldihydroxyacetonephosphate Synthase Deficiency
Synonym: Alkyldihydroxyacetonephosphate synthase deficiency
Synonym: Alkylglycerone-Phosphate Synthase Deficiency
Synonym: RCDP3
Synonym: RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 3
Tree Number: T10.5.10.1.1
database_cross_reference: DO:DOID:0110853
database_cross_reference: MEDCIN:312736
database_cross_reference: MSH:C537608
database_cross_reference: OMIM:600121
database_cross_reference: OMIM:603051

rhizomelic chondrodysplasia punctata type 5
type: Class
subclass of: rhizomelic chondrodysplasia punctata
definition: A rhizomelic chondrodysplasia punctata that has material basis in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the PEX5 gene on chromosome 12p13.31.
PMOID: PMO:00028834
Subclass_of: rhizomelic chondrodysplasia punctata
Synonym: RCDP5
Synonym: RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 5
Synonym: Rcdp5
Tree Number: T10.5.10.1.4
database_cross_reference: DO:DOID:0110854
database_cross_reference: OMIM:600414
database_cross_reference: OMIM:616716

holoprosencephaly 2
type: Class
subclass of: holoprosencephaly
definition: A holoprosencephaly that has_material_basis_in mutation in the homeobox-containing SIX3 gene on chromosome 2p21.
PMOID: PMO:00028252
Subclass_of: holoprosencephaly
Synonym: HOLOPROSENCEPHALY 2
Synonym: HOLOPROSENCEPHALY 2 (disorder)
Synonym: HPE2
Synonym: Holoprosencephaly 2
Synonym: Holoprosencephaly Type 2
Tree Number: T10.4.1.5.9
database_cross_reference: DO:DOID:0110872
database_cross_reference: MSH:C563579
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C74995
database_cross_reference: OMIM:157170
database_cross_reference: OMIM:603714

holoprosencephaly 9
type: Class
subclass of: holoprosencephaly
definition: A holoprosencephaly that has_material_basis_in heterozygous mutation in the GLI2 gene on chromosome 2q14.
PMOID: PMO:00028249
Subclass_of: holoprosencephaly
Synonym: HOLOPROSENCEPHALY 9
Synonym: HOLOPROSENCEPHALY WITH MICROPHTHALMIA AND FIRST BRANCHIAL ARCH ANOMALIES
Synonym: HPE9
Synonym: Holoprosencephaly 9
Synonym: PITUITARY ANOMALIES WITH HOLOPROSENCEPHALY-LIKE FEATURES
Synonym: PITUITARY ANOMALIES WITH HOLOPROSENCEPHALY-LIKE FEATURES (disorder)
Synonym: Pituitary Anomalies with Holoprosencephaly-Like Features
Synonym: holoprosencephaly with microphthalmia and first branchial arch anomalies
Synonym: pituitary anomalies with holoprosencephaly-like features
Tree Number: T10.4.1.5.6
database_cross_reference: DO:DOID:0110873
database_cross_reference: MSH:C563659
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:165230
database_cross_reference: OMIM:610829

holoprosencephaly 6
type: Class
subclass of: holoprosencephaly
definition: A holoprosencephaly that has_material_basis_in variation in the chromosome region 2q37.1-q37.3.
PMOID: PMO:00028247
Subclass_of: holoprosencephaly
Synonym: HOLOPROSENCEPHALY 6
Synonym: HPE6
Synonym: Holoprosencephaly 6
Tree Number: T10.4.1.5.4
database_cross_reference: DO:DOID:0110874
database_cross_reference: MSH:C565274
database_cross_reference: OMIM:605934

holoprosencephaly 3
type: Class
subclass of: holoprosencephaly
definition: A holoprosencephaly that has_material_basis_in heterozygous mutation in the SHH gene on chromosome 7q36.
PMOID: PMO:00028251
Subclass_of: holoprosencephaly
Synonym: HLP3
Synonym: HOLOPROSENCEPHALY 3
Synonym: HPE3
Synonym: Holoprosencephaly 3
Tree Number: T10.4.1.5.8
database_cross_reference: DO:DOID:0110875
database_cross_reference: MSH:C564181
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:142945
database_cross_reference: OMIM:600725

holoprosencephaly 7
type: Class
subclass of: holoprosencephaly
definition: A holoprosencephaly that has_material_basis_in heterozygous mutation in the PTCH1 gene on chromosome 9q22.
PMOID: PMO:00028246
Subclass_of: holoprosencephaly
Synonym: HOLOPROSENCEPHALY 7
Synonym: HPE7
Synonym: Holoprosencephaly 7
Tree Number: T10.4.1.5.3
database_cross_reference: DO:DOID:0110876
database_cross_reference: MSH:C563660
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:601309
database_cross_reference: OMIM:610828

holoprosencephaly 11
type: Class
subclass of: holoprosencephaly
definition: A holoprosencephaly that has_material_basis_in heterozygous mutation in the CDON gene on chromosome 11q24.
PMOID: PMO:00028244
Subclass_of: holoprosencephaly
Synonym: HOLOPROSENCEPHALY 11
Synonym: HPE11
Tree Number: T10.4.1.5.1
database_cross_reference: DO:DOID:0110877
database_cross_reference: OMIM:608707
database_cross_reference: OMIM:614226

holoprosencephaly 5
type: Class
subclass of: holoprosencephaly
definition: A holoprosencephaly that has_material_basis_in heterozygous mutation in the ZIC2 gene on chromosome 13q32.
PMOID: PMO:00028248
Subclass_of: holoprosencephaly
Synonym: HOLOPROSENCEPHALY 5
Synonym: HPE5
Synonym: Holoprosencephaly 5
Synonym: Holoprosencephaly Type 5
Tree Number: T10.4.1.5.5
database_cross_reference: DO:DOID:0110878
database_cross_reference: MSH:C566464
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75460
database_cross_reference: OMIM:603073
database_cross_reference: OMIM:609637

holoprosencephaly 8
type: Class
subclass of: holoprosencephaly
definition: A holoprosencephaly that has_material_basis_in variation in the chromosome region 14q13.
PMOID: PMO:00028245
Subclass_of: holoprosencephaly
Synonym: HOLOPROSENCEPHALY 8
Synonym: HPE8
Synonym: Holoprosencephaly 8
Tree Number: T10.4.1.5.2
database_cross_reference: DO:DOID:0110879
database_cross_reference: MSH:C563723
database_cross_reference: OMIM:609408

holoprosencephaly 4
type: Class
subclass of: holoprosencephaly
definition: A holoprosencephaly that has_material_basis_in heterozygous mutation in the TGIF gene on chromosome 18p11.
PMOID: PMO:00028250
Subclass_of: holoprosencephaly
Synonym: HOLOPROSENCEPHALY 4
Synonym: HOLOPROSENCEPHALY 4 (disorder)
Synonym: HPE4
Synonym: Holoprosencephaly 4
Synonym: Holoprosencephaly Type 4
Tree Number: T10.4.1.5.7
database_cross_reference: DO:DOID:0110880
database_cross_reference: MSH:C564180
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75475
database_cross_reference: OMIM:142946
database_cross_reference: OMIM:602630

holoprosencephaly 1
type: Class
subclass of: holoprosencephaly
definition: A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies.
PMOID: PMO:00028253
Subclass_of: holoprosencephaly
Synonym: Familial alobar holoprosencephaly
Synonym: Familial alobar holoprosencephaly (disorder)
Synonym: Familial alobar holoprosencephaly -RETIRED-
Synonym: HPE - Holoprosencephaly
Synonym: HPE, FAMILIAL
Synonym: HPE1
Synonym: HPEC
Synonym: Holoprosencephalies
Synonym: Holoprosencephaly
Synonym: Holoprosencephaly (HPE)
Tree Number: T10.4.1.5.10
database_cross_reference: CHV:0000015186
database_cross_reference: CSP:0723-2277
database_cross_reference: DO:DOID:0110881
database_cross_reference: DO:DOID:4621
database_cross_reference: HPO:HP:0001360
database_cross_reference: ICD10:Q04.2
database_cross_reference: ICD10AM:Q04.2
database_cross_reference: ICD10CM:Q04.2
database_cross_reference: LCH_NW:sh89007234
database_cross_reference: MDR:10056304
database_cross_reference: MEDCIN:218980
database_cross_reference: MSH:D016142
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:742.2
database_cross_reference: NCI:C74988
database_cross_reference: NCI_NICHD:C74988
database_cross_reference: NDFRT:N0000003376
database_cross_reference: OMIM:236100
database_cross_reference: OMIM:MTHU000059
database_cross_reference: OMIM:MTHU026541
database_cross_reference: RCD:P225.
database_cross_reference: SNM:M-20220
database_cross_reference: SNMI:D4-01520
database_cross_reference: SNOMEDCT_US:30915001
database_cross_reference: SNOMEDCT_US:44519006

Joubert syndrome 1
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous mutation in the INPP5E gene on chromosome 9q34.
PMOID: PMO:00028293
Subclass_of: Joubert syndrome
Synonym: Agenesis of Cerebellar Vermis
Synonym: Agenesis of cerebellar vermis
Synonym: CEREBELLOOCULORENAL SYNDROME 1
Synonym: CEREBELLOPARENCHYMAL DISORDER IV
Synonym: CORS1
Synonym: CPD4
Synonym: Cerebellar vermis agenesis
Synonym: Cerebellar vermis aplasia
Synonym: Cerebello-Oculo-Renal Syndrome
Synonym: Cerebellooculorenal syndrome 1
Tree Number: T10.5.1.1.1
database_cross_reference: CHV:0000034162
database_cross_reference: CSP:0944-7801
database_cross_reference: CSP:1254-7727
database_cross_reference: DO:DOID:0110980
database_cross_reference: HPO:HP:0002335
database_cross_reference: JABL:375
database_cross_reference: MDR:10078574
database_cross_reference: MEDCIN:312974
database_cross_reference: MSH:C536293
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C74996
database_cross_reference: OMIM:213300
database_cross_reference: OMIM:613037
database_cross_reference: OMIM:MTHU000200
database_cross_reference: OMIM:MTHU039930
database_cross_reference: RCD:X77rY
database_cross_reference: SNOMEDCT_US:156895002
database_cross_reference: SNOMEDCT_US:204053001
database_cross_reference: SNOMEDCT_US:253175003
database_cross_reference: SNOMEDCT_US:716997004

Joubert syndrome 10
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in X-linked recessive inheritance of mutation in the OFD1 gene on chromosome Xp22.2.
PMOID: PMO:00028306
Subclass_of: Joubert syndrome
Synonym: JBTS10
Synonym: JOUBERT SYNDROME 10
Synonym: JOUBERT SYNDROME 10 (disorder)
Synonym: Joubert Syndrome 10
Tree Number: T10.5.1.1.14
database_cross_reference: DO:DOID:0110981
database_cross_reference: MSH:C567582
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300170
database_cross_reference: OMIM:300804

Joubert syndrome 13
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the TCTN1 gene on chromosome 12q24.
PMOID: PMO:00028308
Subclass_of: Joubert syndrome
Synonym: JBTS13
Synonym: JOUBERT SYNDROME 13
Tree Number: T10.5.1.1.16
database_cross_reference: DO:DOID:0110982
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:609863
database_cross_reference: OMIM:614173

Joubert syndrome 14
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome characterized by severe mental retardation, hypoplasia of the cerebellar vermis and molar tooth sign on brain imaging, hypotonia, abnormal breathing pattern in infancy, and dysmorphic facial features that has_material_basis_in homozygous or compound heterozygous mutation in the TMEM237 gene on chromosome 2q33.
PMOID: PMO:00028307
Subclass_of: Joubert syndrome
Synonym: JBTS14
Synonym: JOUBERT SYNDROME 14
Tree Number: T10.5.1.1.15
database_cross_reference: DO:DOID:0110983
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:614423
database_cross_reference: OMIM:614424

Joubert syndrome 15
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome characterized by ataxia, hypotonia, delayed psychomotor development, and variable mental retardation that has_material_basis_in homozygous mutation in the CEP41 gene on chromosome 7q32.
PMOID: PMO:00028310
Subclass_of: Joubert syndrome
Synonym: JBTS15
Synonym: JOUBERT SYNDROME 15
Tree Number: T10.5.1.1.18
database_cross_reference: DO:DOID:0110984
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:610523
database_cross_reference: OMIM:614464

Joubert syndrome 16
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome characterized by molar tooth sign on brain imaging, oculomotor apraxia, variable coloboma, and rare kidney involvement that has_material_basis_in homozygous mutation in the TMEM138 gene on chromosome 11q.
PMOID: PMO:00028309
Subclass_of: Joubert syndrome
Synonym: JBTS16
Synonym: JOUBERT SYNDROME 16
Tree Number: T10.5.1.1.17
database_cross_reference: DO:DOID:0110985
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:614459
database_cross_reference: OMIM:614465

Joubert syndrome 17
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome characterized by episodic hyperpnea, abnormal eye movements, ataxia, and global psychomotor retardation that has_material_basis_in compound heterozygous mutation in the C5ORF42 gene on chromosome 5p13.
PMOID: PMO:00028312
Subclass_of: Joubert syndrome
Synonym: JBTS17
Synonym: JOUBERT SYNDROME 17
Tree Number: T10.5.1.1.20
database_cross_reference: DO:DOID:0110986
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:614571
database_cross_reference: OMIM:614615

Joubert syndrome 18
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous mutation in the TCTN3 gene on chromosome 10q24.
PMOID: PMO:00028311
Subclass_of: Joubert syndrome
Synonym: JBTS18
Synonym: JOUBERT SYNDROME 18
Tree Number: T10.5.1.1.19
database_cross_reference: DO:DOID:0110987
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:613847
database_cross_reference: OMIM:614815

Joubert syndrome 2
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome characterized by molar tooth sign on brain MRI, hypotonia, developmental delay, oculomotor apraxia, and breathing abnormalities that has_material_basis_in mutation in the TMEM216 gene on chromosome 11q12.2.
PMOID: PMO:00028294
Subclass_of: Joubert syndrome
Synonym: CEREBELLOOCULORENAL SYNDROME 2
Synonym: CORS2
Synonym: Cerebellooculorenal syndrome 2
Synonym: JBTS2
Synonym: JOUBERT SYNDROME 2
Synonym: cerebellooculorenal syndrome 2
Tree Number: T10.5.1.1.2
database_cross_reference: DO:DOID:0110988
database_cross_reference: MSH:C536294
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:608091
database_cross_reference: OMIM:613277

Joubert syndrome 20
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in compound heterozygous mutation in the TMEM231 gene on chromosome 16q23.
PMOID: PMO:00028314
Subclass_of: Joubert syndrome
Synonym: JBTS20
Synonym: JOUBERT SYNDROME 20
Tree Number: T10.5.1.1.22
database_cross_reference: DO:DOID:0110989
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:614949
database_cross_reference: OMIM:614970

Joubert syndrome 21
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the CSPP1 gene on chromosome 8q13.
PMOID: PMO:00028313
Subclass_of: Joubert syndrome
Synonym: JBTS21
Synonym: JOUBERT SYNDROME 21
Tree Number: T10.5.1.1.21
database_cross_reference: DO:DOID:0110990
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:611654
database_cross_reference: OMIM:615636

Joubert syndrome 22
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous mutation in the PDE6D gene on chromosome 2q37.
PMOID: PMO:00028316
Subclass_of: Joubert syndrome
Synonym: JBTS22
Synonym: JOUBERT SYNDROME 22
Tree Number: T10.5.1.1.24
database_cross_reference: DO:DOID:0110991
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:615665

Joubert syndrome 23
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome characterized by delayed development, abnormal eye movements, and abnormal breathing pattern, and molar tooth sign on brain MRI that has_material_basis_in homozygous or compound heterozygous mutation in the KIAA0586 gene on chromosome 14q23.
PMOID: PMO:00028315
Subclass_of: Joubert syndrome
Synonym: JBTS23
Synonym: JOUBERT SYNDROME 23
Tree Number: T10.5.1.1.23
database_cross_reference: DO:DOID:0110992
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:610178
database_cross_reference: OMIM:616490

Joubert syndrome 24
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome characterized by delayed psychomotor development and molar tooth sign on brain MRI that has_material_basis_in homozygous mutation in the TCTN2 gene on chromosome 12q24.
PMOID: PMO:00028318
Subclass_of: Joubert syndrome
Synonym: JBTS24
Synonym: JOUBERT SYNDROME 24
Tree Number: T10.5.1.1.26
database_cross_reference: DO:DOID:0110993
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:613846
database_cross_reference: OMIM:616654

Joubert syndrome 25
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome characterized by delayed psychomotor development, oculomotor apraxia, and molar tooth sign on brain MRI that has_material_basis_in homozygous or compound heterozygous mutation in the CEP104 gene on chromosome 1p36.
PMOID: PMO:00028317
Subclass_of: Joubert syndrome
Synonym: JBTS25
Synonym: JOUBERT SYNDROME 25
Tree Number: T10.5.1.1.25
database_cross_reference: DO:DOID:0110994
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:616690
database_cross_reference: OMIM:616781

Joubert syndrome 26
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome characterized by global developmental delay and cerebellar hypoplasia that has_material_basis_in homozygous mutation in the KIAA0556 gene on chromosome 16p12.
PMOID: PMO:00028320
Subclass_of: Joubert syndrome
Synonym: JBTS26
Synonym: JOUBERT SYNDROME 26
Tree Number: T10.5.1.1.28
database_cross_reference: DO:DOID:0110995
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:616784

Joubert syndrome 27
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the B9D1 gene on chromosome 17p11.
PMOID: PMO:00028319
Subclass_of: Joubert syndrome
Synonym: JBTS27
Synonym: JOUBERT SYNDROME 27
Tree Number: T10.5.1.1.27
database_cross_reference: DO:DOID:0110996
database_cross_reference: OMIM:614144
database_cross_reference: OMIM:617120

Joubert syndrome 28
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the MKS1 gene on chromosome 17q23.
PMOID: PMO:00028322
Subclass_of: Joubert syndrome
Synonym: JBTS28
Synonym: JOUBERT SYNDROME 28
Tree Number: T10.5.1.1.30
database_cross_reference: DO:DOID:0110997
database_cross_reference: OMIM:609883
database_cross_reference: OMIM:617121

Joubert syndrome 3
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous mutation in the AHI1 gene on chromosome 6q23.3.
PMOID: PMO:00028295
Subclass_of: Joubert syndrome
Synonym: JBTS3
Synonym: JOUBERT SYNDROME 3
Tree Number: T10.5.1.1.3
database_cross_reference: DO:DOID:0110998
database_cross_reference: MSH:C536295
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:608629
database_cross_reference: OMIM:608894

Joubert syndrome 4
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in deletions of the NPHP1 gene on chromosome 2q13.
PMOID: PMO:00028296
Subclass_of: Joubert syndrome
Synonym: JBTS4
Synonym: JOUBERT SYNDROME 4
Synonym: JOUBERT SYNDROME 4 (disorder)
Synonym: Joubert Syndrome 4
Synonym: Joubert Syndrome Type 4
Tree Number: T10.5.1.1.4
database_cross_reference: DO:DOID:0110999
database_cross_reference: MSH:C536296
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C74997
database_cross_reference: OMIM:607100
database_cross_reference: OMIM:609583

Joubert syndrome 5
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in mutation in the CEP290 gene on chromosome 12q21.
PMOID: PMO:00028297
Subclass_of: Joubert syndrome
Synonym: JBTS5
Synonym: JOUBERT SYNDROME 5
Tree Number: T10.5.1.1.5
database_cross_reference: DO:DOID:0111000
database_cross_reference: MSH:C537688
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:610142
database_cross_reference: OMIM:610188

Joubert syndrome 6
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the TMEM67 on chromosome 8q22.
PMOID: PMO:00028298
Subclass_of: Joubert syndrome
Synonym: JBTS6
Synonym: JOUBERT SYNDROME 6
Tree Number: T10.5.1.1.6
database_cross_reference: DO:DOID:0111001
database_cross_reference: MSH:C537689
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:609884
database_cross_reference: OMIM:610688

Joubert syndrome 7
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in mutation in the RPGRIP1L gene on chromosome 16q12.2.
PMOID: PMO:00028299
Subclass_of: Joubert syndrome
Synonym: JBTS7
Synonym: JOUBERT SYNDROME 7
Synonym: Joubert Syndrome 7
Tree Number: T10.5.1.1.7
database_cross_reference: DO:DOID:0111002
database_cross_reference: MSH:C566916
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:610937
database_cross_reference: OMIM:611560

Joubert syndrome 8
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in mutation in the ARL13B gene on chromosome 3q11.1-q11.2
PMOID: PMO:00028300
Subclass_of: Joubert syndrome
Synonym: JBTS8
Synonym: JOUBERT SYNDROME 8
Synonym: JOUBERT SYNDROME 8 (disorder)
Synonym: Joubert Syndrome 8
Tree Number: T10.5.1.1.8
database_cross_reference: DO:DOID:0111003
database_cross_reference: MSH:C567358
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:608922
database_cross_reference: OMIM:612291

Joubert syndrome 9
type: Class
subclass of: Joubert syndrome
definition: A Joubert syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the CC2D2A gene on chromosome 4p15.
PMOID: PMO:00028301
Subclass_of: Joubert syndrome
Synonym: JBTS9
Synonym: JOUBERT SYNDROME 9
Synonym: JOUBERT SYNDROME 9 (disorder)
Synonym: Joubert Syndrome 9
Tree Number: T10.5.1.1.9
database_cross_reference: DO:DOID:0111004
database_cross_reference: MSH:C567364
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:612013
database_cross_reference: OMIM:612285

maturity-onset diabetes of the young type 1
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in mutation in the HNF4A gene on chromosome 20.
PMOID: PMO:00028381
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
Synonym: MILD JUVENILE DIABETES MELLITUS
Synonym: MODY type 1
Synonym: MODY, TYPE 1
Synonym: MODY, Type 1
Synonym: MODY1
Synonym: Maturity onset diabetes of the young, type 1
Synonym: Maturity onset diabetes of the young, type 1 (disorder)
Synonym: Maturity-Onset Diabetes of the Young, Type 1
Synonym: Mild Juvenile Diabetes Mellitus
Tree Number: T10.5.2.9
database_cross_reference: DO:DOID:0111099
database_cross_reference: MEDCIN:358415
database_cross_reference: MSH:C565101
database_cross_reference: OMIM:125850
database_cross_reference: OMIM:600281
database_cross_reference: SNOMEDCT_US:609562003

maturity-onset diabetes of the young type 2
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in heterozygous mutation in the GCK gene on chromosome 7p13.
PMOID: PMO:00028380
Subclass_of: maturity-onset diabetes of the young
Synonym: DIABETES MELLITUS, TYPE II, AUTOSOMAL DOMINANT
Synonym: Diab mell aut dom,type II
Synonym: Diabetes Mellitus, Type II, Autosomal Dominant
Synonym: Diabetes mellitus autosomal dominant type 2
Synonym: Diabetes mellitus autosomal dominant type 2 (disorder)
Synonym: Diabetes mellitus autosomal dominant type II
Synonym: Diabetes mellitus autosomal dominant type II (disorder)
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 2
Synonym: MODY - Maturity onset diabetes glucokinase-related
Synonym: MODY - Maturity onset diabetes in youth type 2
Tree Number: T10.5.2.8
database_cross_reference: DO:DOID:0111100
database_cross_reference: MEDCIN:351261
database_cross_reference: MEDCIN:358416
database_cross_reference: MSH:C564219
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:125851
database_cross_reference: OMIM:138079
database_cross_reference: OMIM:610582
database_cross_reference: RCD:X40JJ
database_cross_reference: SNOMEDCT_US:237604008
database_cross_reference: SNOMEDCT_US:390716007

maturity-onset diabetes of the young type 5
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young characterized by abnormal renal development resuting in non-diabetic kidney disease and diabetes that has_material_basis_in mutation in the HNF1B gene on chromosome 17q12.
PMOID: PMO:00028377
Subclass_of: maturity-onset diabetes of the young
Synonym: CAKUT WITH DIABETES
Synonym: CAKUT with diabetes
Synonym: CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT WITH DIABETES
Synonym: FJHN, ATYPICAL
Synonym: Fam hypopl glomerulocyst kidn
Synonym: Familial hypoplastic, glomerulocystic kidney
Synonym: Familial hypoplastic, glomerulocystic kidney (disorder)
Synonym: GLOMERULOCYSTIC KIDNEY DISEASE, HYPOPLASTIC TYPE
Synonym: GLOMERULOCYSTIC KIDNEY, FAMILIAL HYPOPLASTIC
Synonym: Glomerulocystic kidney disease, hypoplastic type
Tree Number: T10.5.2.5
database_cross_reference: DO:DOID:0111101
database_cross_reference: MEDCIN:355408
database_cross_reference: MEDCIN:358419
database_cross_reference: MSH:C535520
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C123018
database_cross_reference: NCI_NICHD:C123018
database_cross_reference: OMIM:137920
database_cross_reference: OMIM:189907
database_cross_reference: RCD:X785X
database_cross_reference: SNOMEDCT_US:253864004
database_cross_reference: SNOMEDCT_US:446641003
database_cross_reference: SNOMEDCT_US:609572000

maturity-onset diabetes of the young type 3
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in mutation in the HNF1A gene on chromosome 12q24.31.
PMOID: PMO:00028379
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
Synonym: MODY type 3
Synonym: MODY, TYPE 3
Synonym: MODY, Type 3
Synonym: MODY3
Synonym: Maturity-Onset Diabetes of the Young, Type 3
Synonym: Maturity-onset diabetes of the young, type 3
Synonym: Maturity-onset diabetes of the young, type 3 (disorder)
Synonym: maturity-onset diabetes of the young - type 3
Tree Number: T10.5.2.7
database_cross_reference: DO:DOID:0111102
database_cross_reference: MEDCIN:358417
database_cross_reference: MSH:C563933
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:142410
database_cross_reference: OMIM:600496
database_cross_reference: SNOMEDCT_US:609570008

maturity-onset diabetes of the young type 4
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in mutation in the PDX1 gene on chromosome 13q12.2.
PMOID: PMO:00028378
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 4
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE IV (disorder)
Synonym: MODY type 4
Synonym: MODY, TYPE 4
Synonym: MODY, Type 4
Synonym: MODY4
Synonym: Maturity-Onset Diabetes of the Young, Type 4
Synonym: Maturity-onset diabetes of the young, type 4
Synonym: Maturity-onset diabetes of the young, type 4 (disorder)
Synonym: maturity-onset diabetes of the young - type 4
Tree Number: T10.5.2.6
database_cross_reference: DO:DOID:0111103
database_cross_reference: MEDCIN:358418
database_cross_reference: MSH:C563451
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:600733
database_cross_reference: OMIM:606392
database_cross_reference: SNOMEDCT_US:609571007

maturity-onset diabetes of the young type 6
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in heterozygous mutation in the NEUROD1 gene on chromosome 2q31.
PMOID: PMO:00028376
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 6
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 6 (disorder)
Synonym: MODY type 6
Synonym: MODY, TYPE 6
Synonym: MODY, Type 6
Synonym: MODY6
Synonym: Maturity-Onset Diabetes of the Young, Type 6
Synonym: Maturity-onset diabetes of the young, type 6
Synonym: Maturity-onset diabetes of the young, type 6 (disorder)
Synonym: maturity-onset diabetes of the young - type 6
Tree Number: T10.5.2.4
database_cross_reference: DO:DOID:0111104
database_cross_reference: MEDCIN:358420
database_cross_reference: MSH:C565231
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:601724
database_cross_reference: OMIM:606394
database_cross_reference: SNOMEDCT_US:609573005

maturity-onset diabetes of the young type 8
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in frameshift deletions in the variable number of tandem repeats of the CEL gene om chromosome 9q34.13.
PMOID: PMO:00028374
Subclass_of: maturity-onset diabetes of the young
Synonym: DIABETES AND PANCREATIC EXOCRINE DYSFUNCTION
Synonym: DIABETES-PANCREATIC EXOCRINE DYSFUNCTION SYNDROME
Synonym: DPED
Synonym: Diabetes and Pancreatic Exocrine Dysfunction
Synonym: Diabetes-Pancreatic Exocrine Dysfunction Syndrome
Synonym: Diabetes-pancreatic exocrine dysfunction syndrome
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 8, WITH EXOCRINE DYSFUNCTION
Synonym: MODY type 8
Synonym: MODY8
Synonym: Maturity-Onset Diabetes of the Young, Type 8, with Exocrine Dysfunction
Tree Number: T10.5.2.2
database_cross_reference: DO:DOID:0111105
database_cross_reference: MEDCIN:358422
database_cross_reference: MSH:C565225
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:114840
database_cross_reference: OMIM:609812
database_cross_reference: SNOMEDCT_US:609575003

maturity-onset diabetes of the young type 7
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in heterozygous mutation in the KLF11 gene on chromosome 2p25.
PMOID: PMO:00028375
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 7
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 7 (disorder)
Synonym: MODY7
Synonym: Maturity-Onset Diabetes of the Young, Type 7
Synonym: Maturity-onset diabetes of the young, type 7
Synonym: Maturity-onset diabetes of the young, type 7 (disorder)
Synonym: maturity-onset diabetes of the young - type 7
Synonym: maturity-onset diabetes of the young - type 7 (diagnosis)
Tree Number: T10.5.2.3
database_cross_reference: DO:DOID:0111106
database_cross_reference: MEDCIN:358421
database_cross_reference: MSH:C566466
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:603301
database_cross_reference: OMIM:610508
database_cross_reference: SNOMEDCT_US:609574004

maturity-onset diabetes of the young type 9
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in heterozygous mutation in the PAX4 gene on chromosome 7q32.1.
PMOID: PMO:00028373
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 9
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 9 (disorder)
Synonym: MODY9
Synonym: Maturity-Onset Diabetes Of The Young, Type 9
Synonym: Maturity-onset diabetes of the young, type 9
Synonym: Maturity-onset diabetes of the young, type 9 (disorder)
Synonym: maturity-onset diabetes of the young - type 9
Synonym: maturity-onset diabetes of the young - type 9 (diagnosis)
Tree Number: T10.5.2.1
database_cross_reference: DO:DOID:0111107
database_cross_reference: MEDCIN:358423
database_cross_reference: MSH:C567393
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:167413
database_cross_reference: OMIM:612225
database_cross_reference: SNOMEDCT_US:609576002

maturity-onset diabetes of the young type 10
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in heterozygous mutation in the INS gene on chromosome 11p15.5.
PMOID: PMO:00028385
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 10
Synonym: MODY10
Synonym: Maturity-onset diabetes of the young, type 10
Synonym: Maturity-onset diabetes of the young, type 10 (disorder)
Synonym: maturity-onset diabetes of the young - type 10
Synonym: maturity-onset diabetes of the young - type 10 (diagnosis)
Tree Number: T10.5.2.13
database_cross_reference: DO:DOID:0111108
database_cross_reference: MEDCIN:358424
database_cross_reference: OMIM:176730
database_cross_reference: OMIM:613370
database_cross_reference: SNOMEDCT_US:609577006

maturity-onset diabetes of the young type 11
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in heterozygous mutation in the BLK gene on chromosome 8p23-p22.
PMOID: PMO:00028384
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 11
Synonym: MODY11
Synonym: Maturity-onset diabetes of the young, type 11
Synonym: Maturity-onset diabetes of the young, type 11 (disorder)
Synonym: maturity-onset diabetes of the young - type 11
Synonym: maturity-onset diabetes of the young - type 11 (diagnosis)
Tree Number: T10.5.2.12
database_cross_reference: DO:DOID:0111109
database_cross_reference: MEDCIN:358425
database_cross_reference: OMIM:191305
database_cross_reference: OMIM:613375
database_cross_reference: SNOMEDCT_US:609578001

maturity-onset diabetes of the young type 13
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in heterozygous mutation in the KCNJ11 gene on chromosome 11p15.
PMOID: PMO:00028383
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 13
Synonym: MODY type 13
Synonym: MODY, TYPE 13
Synonym: MODY13
Tree Number: T10.5.2.11
database_cross_reference: DO:DOID:0111110
database_cross_reference: OMIM:600937
database_cross_reference: OMIM:616329

maturity-onset diabetes of the young type 14
type: Class
subclass of: maturity-onset diabetes of the young
definition: A maturity-onset diabetes of the young that has_material_basis_in heterozygous mutation in the APPL1 gene on chromosome 3p14.
PMOID: PMO:00028382
Subclass_of: maturity-onset diabetes of the young
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 14
Synonym: MODY14
Tree Number: T10.5.2.10
database_cross_reference: DO:DOID:0111111
database_cross_reference: OMIM:604299
database_cross_reference: OMIM:616511

mitochondrial complex III deficiency
type: Class
subclass of: mitochondrial metabolism disease
definition: A mitochondrial metabolism disease characterized by impaired function of one or more of the proteins making up the mitochondrial respiratory chain complex III.
PMOID: PMO:00028956
Subclass_of: mitochondrial metabolism disease
Synonym: Deficiency of isolated CoQ cytochrome c reductase
Synonym: Deficiency of mitochondrial complex III
Synonym: Deficiency of mitochondrial complex III (disorder)
Synonym: Deficiency of ubiquinone cytochrome c oxidoreductase
Synonym: MITOCHONDRIAL COMPLEX III DEFICIENCY (disorder)
Synonym: Mitochondrial Complex III Deficiency
Synonym: Mitochondrial complex III deficiency
Tree Number: T10.6.2.1.2
database_cross_reference: DO:DOID:0111139
database_cross_reference: MSH:C565128
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU047868
database_cross_reference: SNOMEDCT_US:709414007

IGSF1 deficiency syndrome
type: Class
subclass of: X-linked disease
definition: An X-linked disease characterized by hypothyroidism that is present at birth, delayed testosterone increase in puberty, and testicular enlargement in adulthood that has_material_basis_in mutation of the IGSF1 gene on chromosome Xq26.
PMOID: PMO:00028727
Subclass_of: X-linked disease
Synonym: CHTE
Synonym: HYPOTHYROIDISM, CENTRAL, AND TESTICULAR ENLARGEMENT
Synonym: X-linked central congenital hypothyroidism with late-onset macroorchidism
Synonym: X-linked central congenital hypothyroidism with late-onset testicular enlargement
Synonym: central hypothyroidism and testicular enlargement
Tree Number: T10.5.3.4.7
database_cross_reference: DO:DOID:0111140
database_cross_reference: OMIM:300137
database_cross_reference: OMIM:300888

delayed sleep phase syndrome
type: Class
subclass of: sleep disorder
definition: A sleep disorder characterized by an extreme evening preference, sleep-onset insomnia, and difficulty in awakening at the desired time.
PMOID: PMO:00027897
Subclass_of: sleep disorder
Synonym: Circadian rhy-delay slp
Synonym: Circadian rhythm sleep disorder, delayed sleep phase
Synonym: Circadian rhythm sleep disorder, delayed sleep phase type
Synonym: Circadian rhythm sleep disorder, delayed sleep phase type (diagnosis)
Synonym: DSPD
Synonym: Delayed Sleep Phase Syndrome
Synonym: Delayed Sleep Phase Type Circadian Rhythm Sleep Disorder
Synonym: Delayed Sleep-Phase Syndrome
Synonym: Delayed sleep phase syndrome
Synonym: Sleep wake schedule disorder, delayed phase type
Tree Number: T10.3.1.8
database_cross_reference: CHV:0000032233
database_cross_reference: DO:DOID:0111141
database_cross_reference: ICD10CM:G47.21
database_cross_reference: ICD9CM:327.31
database_cross_reference: MEDCIN:279057
database_cross_reference: MEDCIN:358333
database_cross_reference: MSH:D020178
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C95073
database_cross_reference: RCD:X0089
database_cross_reference: SNMI:D9-74132
database_cross_reference: SNOMEDCT_US:28011000119104
database_cross_reference: SNOMEDCT_US:80623000

mitochondrial complex V (ATP synthase) deficiency
type: Class
subclass of: mitochondrial metabolism disease
definition: A mitochondrial metabolism disease characterized by impaired function of one or more of the proteins making up the mitochondrial proton-transporting ATP synthase complex.
PMOID: PMO:00028951
Subclass_of: mitochondrial metabolism disease
Tree Number: T10.6.2.1.1
database_cross_reference: DO:DOID:0111143

preterm premature rupture of the membranes
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation.
PMOID: PMO:00029838
Subclass_of: female reproductive system disease
Synonym: PPROM
Synonym: PPROM - Preterm prem rup, mem
Synonym: PPROM - Preterm premature rupture of membranes
Synonym: PRETERM PREMATURE RUPTURE OF THE MEMBRANES
Synonym: Preterm Premature Rupture of Membrane
Synonym: Preterm Premature Rupture of Membranes
Synonym: Preterm Premature Rupture of the Membranes
Synonym: Preterm premat rupt membranes
Synonym: Preterm premature rupture of membranes
Synonym: Preterm premature rupture of membranes (disorder)
Tree Number: T10.8.1.4.15
database_cross_reference: DO:DOID:0111144
database_cross_reference: MDR:10073024
database_cross_reference: MSH:C563032
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92862
database_cross_reference: NCI_NICHD:C92862
database_cross_reference: OMIM:120353
database_cross_reference: OMIM:120355
database_cross_reference: OMIM:600943
database_cross_reference: OMIM:610504
database_cross_reference: RCD:XaE6o
database_cross_reference: SNOMEDCT_US:312974005

ureteropelvic junction obstruction
type: Class
subclass of: urinary tract obstruction
definition: A CAKUT that has_material_basis_in heterozygous mutation in the TBX18 gene on chromosome 6q14.
PMOID: PMO:00032956
Subclass_of: urinary tract obstruction
Synonym: CAKUT2
Synonym: CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT 2
Synonym: Obstruction of Pelviureteric Junction
Synonym: Obstruction of pelviureteric junction
Synonym: Obstruction of pelviureteric junction (disorder)
Synonym: PELVIURETERIC JUNCTION OBSTRUCTION
Synonym: PUJ - Pelviureteric obstruction
Synonym: PUJ - Pelviureteric obstructn
Synonym: PUJO
Synonym: PUO - Pelviureteric obstruction
Tree Number: T10.8.7.2.1
database_cross_reference: DO:DOID:0080207
database_cross_reference: DO:DOID:0111145
database_cross_reference: HPO:HP:0000074
database_cross_reference: ICD10CM:Q62.39
database_cross_reference: MDR:10034232
database_cross_reference: MDR:10051749
database_cross_reference: MSH:C537373
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C99007
database_cross_reference: NCI_NICHD:C99007
database_cross_reference: OMIM:143400
database_cross_reference: OMIM:604613
database_cross_reference: OMIM:MTHU008668
database_cross_reference: OMIM:MTHU018043
database_cross_reference: RCD:Xa9CE
database_cross_reference: SNMI:D7-11947
database_cross_reference: SNOMEDCT_US:95575002

acquired von Willebrand syndrome
type: Class
subclass of: blood coagulation disease
definition: A blood coagulation disease characterized by development of a defect in clotting in the absence of previous bleeding symptoms, negative familial history, and occurrence in a relatively older age. Typically this develops secondarily to other disorders, such as lymphoproliferative, myeloproliferative, cardiovascular and autoimmune disorders.
PMOID: PMO:00033293
Subclass_of: blood coagulation disease
Synonym: AVWS
Synonym: Acq von Willebrand's disease
Synonym: Acquired Von Willebrand's disease
Synonym: Acquired von Willebrand disease
Synonym: Acquired von Willebrand syndrome
Synonym: Acquired von Willebrand syndrome (disorder)
Synonym: Acquired von Willebrand's disease
Synonym: Acquired von Willebrand's disease (disorder)
Synonym: vWD - Acq von Will disease
Synonym: vWD - Acquired von Willebrand's disease
Tree Number: T10.8.10.1.3
database_cross_reference: DO:DOID:0111146
database_cross_reference: MDR:10069495
database_cross_reference: RCD:X20EP
database_cross_reference: SNMI:DC-64280
database_cross_reference: SNOMEDCT_US:234451005
database_cross_reference: SNOMEDCT_US:60078000

partial trisomy distal 4q
type: Class
subclass of: chromosomal duplication syndrome
definition: A chromosomal duplication syndrome characterized by growth deficiency, abnormal muscle tone, intellectual disability, and distinctive craniofacial malformations that has material basis in duplication of the distal portion of chromosome 4q.
PMOID: PMO:00028764
Subclass_of: chromosomal duplication syndrome
Synonym: Chromosome 4, Partial Trisomy 4q
Synonym: Chromosome 4, partial trisomy distal 4q
Synonym: Distal 4q Trisomy
Synonym: Dup(4q) Syndrome, Partial
Synonym: Duplication 4q Syndrome, Partial
Synonym: Partial Trisomy 4q Syndrome
Tree Number: T10.5.9.5.4
database_cross_reference: DO:DOID:0111159
database_cross_reference: MSH:C537642

camptodactyly-tall stature-scoliosis-hearing loss syndrome
type: Class
subclass of: autosomal genetic disease
definition: An autosomal genetic disease characterized by camptodactyly, tall stature, scoliosis, and hearing loss that has_material_basis_in partial loss of function in the FGFR3 gene on chromosome 4p16.
PMOID: PMO:00028504
Subclass_of: autosomal genetic disease
Synonym: CAMPTODACTYLY, TALL STATURE, AND HEARING LOSS SYNDROME
Synonym: CATSHL SYNDROME
Synonym: CATSHL syndrome
Synonym: CATSHLS
Synonym: Camptodactyly, tall stature, and hearing loss syndrome
Tree Number: T10.5.3.2.8
database_cross_reference: DO:DOID:0111160
database_cross_reference: MSH:C537975
database_cross_reference: OMIM:134934
database_cross_reference: OMIM:610474

epidermal nevus
type: Class
subclass of: skin disease
definition: A skin disease characterized by localized epidermal thickening with hyperpigmentation that develops at or shortly after birth.
PMOID: PMO:00033786
Subclass_of: skin disease
Synonym: Epidermal Naevus
Synonym: Epidermal Nevus
Synonym: Epidermal naevus
Synonym: Epidermal naevus, NOS
Synonym: Epidermal nevi
Synonym: Epidermal nevus
Synonym: Epidermal nevus (disorder)
Synonym: Epidermal nevus (morphologic abnormality)
Synonym: Epidermal nevus, NOS
Synonym: Epithelial naevus
Tree Number: T10.8.12.2.2
database_cross_reference: CHV:0000029906
database_cross_reference: DO:DOID:0111162
database_cross_reference: HPO:HP:0010816
database_cross_reference: MDR:10014985
database_cross_reference: MDR:10062792
database_cross_reference: MSH:C580062
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4088
database_cross_reference: OMIM:162900
database_cross_reference: OMIM:MTHU015910
database_cross_reference: OMIM:MTHU042455
database_cross_reference: RCD:X50JO
database_cross_reference: RCDAE:X50JO
database_cross_reference: SNM:M-75700
database_cross_reference: SNMI:M-75530
database_cross_reference: SNOMEDCT_US:239107007
database_cross_reference: SNOMEDCT_US:25201003
database_cross_reference: SNOMEDCT_US:729000

molybdenum cofactor deficiency
type: Class
subclass of: metal metabolism disorder
PMOID: PMO:00029008
Subclass_of: metal metabolism disorder
Synonym: Comb molybdoflavoprot enz def
Synonym: Comb xan ox & aldehyde ox def
Synonym: Comb xan ox & sulp ox & ald ox
Synonym: Combined molybdoflavoprotein enzyme deficiency
Synonym: Combined molybdoflavoprotein enzyme deficiency (disorder)
Synonym: Combined xanthine oxid & sulph oxid & aldehyde oxidase def
Synonym: Combined xanthine oxidase and aldehyde oxidase deficiency
Synonym: Combined xanthine oxidase and aldehyde oxidase deficiency (disorder)
Synonym: Combined xanthine oxidase and sulfite oxidase and aldehyde oxidase deficiency
Synonym: Combined xanthine oxidase and sulphite oxidase and aldehyde oxidase deficiency
Tree Number: T10.6.2.4.2
database_cross_reference: HPO:HP:0003570
database_cross_reference: MDR:10069687
database_cross_reference: MSH:C535811
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C129076
database_cross_reference: OMIM:252150
database_cross_reference: OMIM:MTHU042064
database_cross_reference: RCD:X40Ue
database_cross_reference: RCD:X40Uf
database_cross_reference: RCDAE:X40Uf
database_cross_reference: SNMI:D6-40520
database_cross_reference: SNOMEDCT_US:238008009
database_cross_reference: SNOMEDCT_US:29692004

subcortical band heterotopia
type: Class
subclass of: congenital nervous system abnormality
definition: A congenital nervous system abnormality characterized by migration of neurons to ectopic locations in the brain where the neurons form areas that appear as band-like clusters of white tissue underneath the gray tissue of the cerebral cortex.
PMOID: PMO:00028240
Subclass_of: congenital nervous system abnormality
Synonym: DC SYNDROME
Synonym: DOUBLE CORTEX SYNDROME
Synonym: Double Cortex Syndrome
Synonym: Double cortex syndrome
Synonym: HeCo
Synonym: Heterotopia, Subcortical Band
Synonym: Heterotopia, Subcortical Laminar
Synonym: Heterotopias, Subcortical Band
Synonym: Heterotopias, Subcortical Laminar
Synonym: SBH
Tree Number: T10.4.1.3
database_cross_reference: DO:DOID:0111169
database_cross_reference: MDR:10073490
database_cross_reference: MSH:D054221
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C116933
database_cross_reference: NCI_NICHD:C116933
database_cross_reference: OMIM:300067
database_cross_reference: OMIM:601545
database_cross_reference: OMIM:607432
database_cross_reference: OMIM:MTHU021696
database_cross_reference: OMIM:MTHU025316

intestinal infectious disease
type: Class
subclass of: intestinal disease
definition: An intestinal disease that involves intestinal infection that has material basis in viruses, bacteria, fungi and parasites.
PMOID: PMO:00033617
Subclass_of: intestinal disease
Synonym: INTESTINAL INFECTIOUS DISEASES
Synonym: Infectious disease of intestine
Synonym: Intestinal infection
Synonym: Intestinal infection (disorder)
Synonym: Intestinal infections
Synonym: Intestinal infectious dis. NOS
Synonym: Intestinal infectious disease
Synonym: Intestinal infectious disease (diagnosis)
Synonym: Intestinal infectious disease (disorder)
Synonym: Intestinal infectious diseases
Tree Number: T10.8.11.8.21
database_cross_reference: CHV:0000018271
database_cross_reference: DO:DOID:100
database_cross_reference: ICD10:A00-A09.9
database_cross_reference: ICD10AM:A00-A09.9
database_cross_reference: ICD10CM:A00-A09
database_cross_reference: ICD9CM:001-009.99
database_cross_reference: MDR:10022678
database_cross_reference: MEDCIN:351879
database_cross_reference: MEDCIN:352550
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:A0z..
database_cross_reference: RCD:XE0Qb
database_cross_reference: SNOMEDCT_US:127322007
database_cross_reference: SNOMEDCT_US:186086003
database_cross_reference: SNOMEDCT_US:186171006
database_cross_reference: SNOMEDCT_US:187266003
database_cross_reference: SNOMEDCT_US:266071000
database_cross_reference: SNOMEDCT_US:266172005
database_cross_reference: SNOMEDCT_US:266180003

pelvic inflammatory disease
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is characterized by an infection of the female reproductive organs.
PMOID: PMO:00029807
Subclass_of: female reproductive system disease
Synonym: 7-71 INFLAMMATORY DISEASES OF THE FEMALE GENITAL ORGANS AND TISSUES
Synonym: DISEASE PELVIC INFLAMMATORY
Synonym: Disease (PID), Pelvic Inflammatory
Synonym: Disease pelvic inflammatory
Synonym: Disease, Inflammatory Pelvic
Synonym: Disease, Pelvic Inflammatory
Synonym: Disease;pelvic inflammatory
Synonym: Diseases, Inflammatory Pelvic
Synonym: Diseases, Pelvic Inflammatory
Synonym: Fem pelv inflam dis NOS
Tree Number: T10.8.1.4.6
database_cross_reference: BI:BI00397
database_cross_reference: CCPSS:0036489
database_cross_reference: CHV:0000023622
database_cross_reference: CHV:0000024729
database_cross_reference: COSTAR:566
database_cross_reference: CSP:2587-6141
database_cross_reference: CST:SALPINGITIS
database_cross_reference: DO:DOID:1003
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:N70-N77.9
database_cross_reference: ICD10:N73.9
database_cross_reference: ICD10AM:N70-N77.9
database_cross_reference: ICD10AM:N73.9
database_cross_reference: ICD10CM:N70-N77
database_cross_reference: ICD10CM:N73.9
database_cross_reference: ICD9CM:614-616.99
database_cross_reference: ICD9CM:614.9
database_cross_reference: ICPC2EENG:X74
database_cross_reference: ICPC2P:X74003
database_cross_reference: ICPC2P:X74004
database_cross_reference: LCH_NW:sh85000943
database_cross_reference: MDR:10013114
database_cross_reference: MDR:10021965
database_cross_reference: MDR:10034253
database_cross_reference: MDR:10034254
database_cross_reference: MDR:10034257
database_cross_reference: MDR:10035006
database_cross_reference: MDR:10035007
database_cross_reference: MDR:10045962
database_cross_reference: MEDCIN:31277
database_cross_reference: MEDLINEPLUS:3044
database_cross_reference: MSH:D000292
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:614.9
database_cross_reference: NCI:C3889
database_cross_reference: NCI_CTCAE:E11501
database_cross_reference: NCI_FDA:2000
database_cross_reference: NCI_NCI-GLOSS:CDR0000658027
database_cross_reference: NCI_NCI-GLOSS:CDR0000658028
database_cross_reference: NCI_NICHD:C3889
database_cross_reference: NDFRT:N0000010319
database_cross_reference: RCD:K4...
database_cross_reference: RCD:K4z..
database_cross_reference: RCD:Kyu8.
database_cross_reference: RCD:XE0eR
database_cross_reference: RCDSY:Kyu8.
database_cross_reference: SNM:D-2455
database_cross_reference: SNMI:D7-71000
database_cross_reference: SNOMEDCT_US:155967009
database_cross_reference: SNOMEDCT_US:155968004
database_cross_reference: SNOMEDCT_US:155974004
database_cross_reference: SNOMEDCT_US:155986001
database_cross_reference: SNOMEDCT_US:198130006
database_cross_reference: SNOMEDCT_US:198131005
database_cross_reference: SNOMEDCT_US:198178006
database_cross_reference: SNOMEDCT_US:198244005
database_cross_reference: SNOMEDCT_US:198570007
database_cross_reference: SNOMEDCT_US:266584000
database_cross_reference: SNOMEDCT_US:266648001
database_cross_reference: SNOMEDCT_US:266651008
database_cross_reference: SNOMEDCT_US:37518008

hymenolepiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the bowel by Hymenolepis nana or Hymenolepis diminuta. The symptoms include diarrhea, gastrointestinal discomfort, itchy anus, poor appetite and weakness.
PMOID: PMO:00029628
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Hymenolepis infectious disease
Synonym: dwarf tapeworm infection
Tree Number: T10.7.4.1.11
database_cross_reference: DO:DOID:10074

diphyllobothriasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia.
PMOID: PMO:00029636
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Diphyllobothrium infection
Synonym: fish tapeworm
Tree Number: T10.7.4.1.14
database_cross_reference: DO:DOID:10075

sparganosis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected.
PMOID: PMO:00029663
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Sparganum
Synonym: Sparganosis
Tree Number: T10.7.4.1.31
database_cross_reference: DO:DOID:10080

intracranial abscess
type: Class
subclass of: central nervous system disease
definition: A central nervous system disease that is located_in the skull and is characterized by a collection of pus (infected material) inside the skull.
PMOID: PMO:00030706
Subclass_of: central nervous system disease
Synonym: Intracranial Abscess
Synonym: Intracranial abscess
Synonym: Intracranial abscess (disorder)
Synonym: Intracranial abscess NOS
Synonym: Intracranial abscess NOS (disorder)
Synonym: Intracranial abscess, NOS
Synonym: intracranial abscess (diagnosis)
Tree Number: T10.8.2.9.10
database_cross_reference: DO:DOID:10095
database_cross_reference: ICD9CM:324.0
database_cross_reference: MDR:10022755
database_cross_reference: MEDCIN:275252
database_cross_reference: NCI:C34734
database_cross_reference: RCD:F040z
database_cross_reference: RCD:XE2rq
database_cross_reference: SNMI:DA-10400
database_cross_reference: SNOMEDCT_US:192738001
database_cross_reference: SNOMEDCT_US:192746000
database_cross_reference: SNOMEDCT_US:27614006

trypanosomiasis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans.
PMOID: PMO:00029682
Subclass_of: parasitic protozoa infectious disease
Synonym: African sleeping sickness
Synonym: African trypanosomiasis
Synonym: Trypanosomiases
Synonym: Trypanosomiasis
Synonym: Trypanosomiasis (disorder)
Synonym: Trypanosomiasis NOS
Synonym: Trypanosomiasis NOS (disorder)
Synonym: Trypanosomiasis [Disease/Finding]
Synonym: Trypanosomiasis, unspecified
Synonym: Trypanosomosis
Tree Number: T10.7.4.2.4
database_cross_reference: CHV:0000012611
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2214-6161
database_cross_reference: DO:DOID:10112
database_cross_reference: DO:DOID:10113
database_cross_reference: ICD10CM:B57.2
database_cross_reference: ICD9CM:086
database_cross_reference: ICD9CM:086.9
database_cross_reference: ICPC2P:A78032
database_cross_reference: LCH:U004800
database_cross_reference: LCH_NW:sh85138293
database_cross_reference: MDR:10044707
database_cross_reference: MDR:10044709
database_cross_reference: MDR:10044710
database_cross_reference: MEDCIN:97518
database_cross_reference: MSH:D014352
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003025
database_cross_reference: RCD:A86..
database_cross_reference: RCD:A86z.
database_cross_reference: SNM:D-0763
database_cross_reference: SNMI:DE-55000
database_cross_reference: SNOMEDCT_US:154375001
database_cross_reference: SNOMEDCT_US:186819000
database_cross_reference: SNOMEDCT_US:266205000
database_cross_reference: SNOMEDCT_US:78940002

pigmentation disease
type: Class
subclass of: skin disease
PMOID: PMO:00033945
Subclass_of: skin disease
Synonym: Other dyschromia
Tree Number: T10.8.12.2.33
database_cross_reference: DO:DOID:10123
database_cross_reference: ICD9CM:709.09
database_cross_reference: MDR:10032021

psychologic vaginismus
type: Class
subclass of: psychosexual disorder
PMOID: PMO:00028160
Subclass_of: psychosexual disorder
Synonym: Functional vaginismus
Synonym: Non-organic vaginismus
Synonym: Non-organic vaginismus (disorder)
Synonym: Nonorganic vaginismus
Synonym: Psychogenic Vaginismus
Synonym: Psychogenic vaginismus
Synonym: Psychologic vaginismus
Synonym: Psychologic vaginismus (disorder)
Synonym: Vaginismus
Synonym: Vaginismus psychogenic
Tree Number: T10.3.11.4.2
database_cross_reference: AOD:0000006838
database_cross_reference: CHV:0000012878
database_cross_reference: DO:DOID:10131
database_cross_reference: ICD10:F52.5
database_cross_reference: ICD10AM:F52.5
database_cross_reference: ICD10CM:F52.5
database_cross_reference: ICD9CM:306.51
database_cross_reference: ICPC2P:P08012
database_cross_reference: MDR:10037204
database_cross_reference: MDR:10046949
database_cross_reference: MEDCIN:32827
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:306.51
database_cross_reference: NCI:C35113
database_cross_reference: PSY:55160
database_cross_reference: RCD:E2651
database_cross_reference: SNMI:D9-73542
database_cross_reference: SNOMEDCT_US:154924008
database_cross_reference: SNOMEDCT_US:192469003
database_cross_reference: SNOMEDCT_US:268773000
database_cross_reference: SNOMEDCT_US:71787009

psychosexual disorder
type: Class
subclass of: sexual disorder
PMOID: PMO:00028158
Subclass_of: sexual disorder
Synonym: 9-73 PSYCHOSEXUAL DISORDERS
Synonym: Disorder, Psychosexual
Synonym: Disorders, Psychosexual
Synonym: Dysfunction, Psychological Sexual
Synonym: Dysfunction, Psychosexual
Synonym: Dysfunctions, Psychological Sexual
Synonym: Dysfunctions, Psychosexual
Synonym: Non-organic sexual dysfunction
Synonym: PSYCHOSEXUAL DIS
Synonym: PSYCHOSEXUAL DISORDERS
Tree Number: T10.3.11.4
database_cross_reference: AOD:0000006785
database_cross_reference: CHV:0000010341
database_cross_reference: COSTAR:NOCODE
database_cross_reference: ICD9CM:302.9
database_cross_reference: LCH:U003921
database_cross_reference: LCH_NW:sh85108504
database_cross_reference: MDR:10037222
database_cross_reference: MDR:10037223
database_cross_reference: MDR:10037233
database_cross_reference: MDR:10046121
database_cross_reference: MEDCIN:353894
database_cross_reference: MSH:D020018
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003984
database_cross_reference: RCD:E22z.
database_cross_reference: SNM:D-9501
database_cross_reference: SNM:F-96090
database_cross_reference: SNMI:D9-73000
database_cross_reference: SNOMEDCT_US:191800007
database_cross_reference: SNOMEDCT_US:56627002

cholelithiasis
type: Class
subclass of: gallbladder disease
PMOID: PMO:00033638
Subclass_of: gallbladder disease
Synonym: Biliary Calculi
Synonym: Biliary calculus
Synonym: Biliary calculus (disorder)
Synonym: Biliary calculus (disorder) [Ambiguous]
Synonym: Biliary calculus, NOS
Synonym: Biliary stones
Synonym: CHOLELITHIASIS
Synonym: CL - Cholelithiasis
Synonym: Calculus - biliary
Synonym: Calculus biliary
Tree Number: T10.8.11.10.7
database_cross_reference: AOD:0000005679
database_cross_reference: AOD:0000005681
database_cross_reference: BI:BI00219
database_cross_reference: CCPSS:0060028
database_cross_reference: CHV:0000002871
database_cross_reference: COSTAR:177
database_cross_reference: CSP:0413-4335
database_cross_reference: CST:CHOLELITH
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000338
database_cross_reference: DXP:U001637
database_cross_reference: HPO:HP:0001081
database_cross_reference: ICD10:K80
database_cross_reference: ICD10AM:K80
database_cross_reference: ICD10CM:K80
database_cross_reference: ICD9CM:574
database_cross_reference: ICPC2P:D98007
database_cross_reference: ICPC2P:D98010
database_cross_reference: LNC:LA14289-5
database_cross_reference: MDR:10004674
database_cross_reference: MDR:10006986
database_cross_reference: MDR:10008629
database_cross_reference: MDR:10017650
database_cross_reference: MEDCIN:30048
database_cross_reference: MEDLINEPLUS:4643
database_cross_reference: MSH:D002769
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C122822
database_cross_reference: NCI_NICHD:C122822
database_cross_reference: NDFRT:N0000000760
database_cross_reference: NDFRT:N0000011058
database_cross_reference: OMIM:MTHU009745
database_cross_reference: RCD:J64z.
database_cross_reference: RCD:XE0bD
database_cross_reference: SNM:M-30010
database_cross_reference: SNMI:D5-85500
database_cross_reference: SNOMEDCT_US:155823008
database_cross_reference: SNOMEDCT_US:197376000
database_cross_reference: SNOMEDCT_US:197403005
database_cross_reference: SNOMEDCT_US:197406002
database_cross_reference: SNOMEDCT_US:266474003
database_cross_reference: SNOMEDCT_US:266541001
database_cross_reference: SNOMEDCT_US:44900007

pinta disease
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Treponema carateum, which is transmitted_by contact with skin and mucous membrane of an infected person. The infection has_symptom pruritic plaque, which slowly enlarges and becomes pigmented and hyperkeratotic.
PMOID: PMO:00029530
Subclass_of: primary bacterial infectious disease
Synonym: AZUL
Synonym: Azul
Synonym: CARATE
Synonym: Carate
Synonym: Carate, NOS
Synonym: E-133 PINTA
Synonym: Infection by Treponema carateum
Synonym: MAL DEL PINTO
Synonym: Mal del pinto
Synonym: PINTA
Tree Number: T10.7.3.1.25
database_cross_reference: CHV:0000009744
database_cross_reference: CSP:0368-3344
database_cross_reference: DO:DOID:1022
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001503
database_cross_reference: ICD10:A67
database_cross_reference: ICD10:A67.9
database_cross_reference: ICD10AM:A67
database_cross_reference: ICD10AM:A67.9
database_cross_reference: ICD10CM:A67
database_cross_reference: ICD10CM:A67.9
database_cross_reference: ICD9CM:103
database_cross_reference: ICD9CM:103.9
database_cross_reference: LCH:U003684
database_cross_reference: LCH_NW:sh85102277
database_cross_reference: MDR:10035068
database_cross_reference: MDR:10035069
database_cross_reference: MDR:10053032
database_cross_reference: MEDCIN:31082
database_cross_reference: MSH:D010874
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85011
database_cross_reference: NDFRT:N0000002405
database_cross_reference: RCD:AA3..
database_cross_reference: RCD:AA3z.
database_cross_reference: RCD:Ayu53
database_cross_reference: RCDSY:Ayu53
database_cross_reference: SNM:D-0161
database_cross_reference: SNMI:DE-13300
database_cross_reference: SNOMEDCT_US:186976002
database_cross_reference: SNOMEDCT_US:187373005
database_cross_reference: SNOMEDCT_US:22064009

exhibitionism
type: Class
subclass of: paraphilia disorder
PMOID: PMO:00028153
Subclass_of: paraphilia disorder
Synonym: (Exhibitionism) or (flasher)
Synonym: (Exhibitionism) or (flasher) (disorder)
Synonym: Exhibitionism
Synonym: Exhibitionism (disorder)
Synonym: Exhibitionism [Disease/Finding]
Synonym: Exhibitionisms
Synonym: Exhibitionist
Synonym: Flasher
Synonym: exhibitionism (diagnosis)
Synonym: exhibitionist
Tree Number: T10.3.11.2.2
database_cross_reference: AOD:0000006790
database_cross_reference: CHV:0000004766
database_cross_reference: CHV:0000050747
database_cross_reference: DO:DOID:10236
database_cross_reference: ICD10:F65.2
database_cross_reference: ICD10AM:F65.2
database_cross_reference: ICD10CM:F65.2
database_cross_reference: ICD9CM:302.4
database_cross_reference: ICPC2P:P09008
database_cross_reference: LCH:U001702
database_cross_reference: LCH_NW:sh85046353
database_cross_reference: MDR:10015670
database_cross_reference: MDR:10015671
database_cross_reference: MDR:10016756
database_cross_reference: MEDCIN:32816
database_cross_reference: MSH:D005084
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94352
database_cross_reference: NDFRT:N0000001172
database_cross_reference: PSY:18420
database_cross_reference: RCD:XE1YN
database_cross_reference: SNM:F-99200
database_cross_reference: SNMI:D9-73160
database_cross_reference: SNOMEDCT_US:154907002
database_cross_reference: SNOMEDCT_US:191781000
database_cross_reference: SNOMEDCT_US:192514003
database_cross_reference: SNOMEDCT_US:268763002
database_cross_reference: SNOMEDCT_US:58349009

leprosy
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.
PMOID: PMO:00029593
Subclass_of: primary bacterial infectious disease
Synonym: Disease, Hansen
Synonym: Disease, Hansen's
Synonym: Disease;Hansens (Leprosy)
Synonym: E-123 LEPROSY
Synonym: HANSEN DIS
Synonym: HANSEN DISEASE
Synonym: HANSENS DIS
Synonym: Hansen Disease
Synonym: Hansen's Disease
Synonym: Hansen's disease
Tree Number: T10.7.3.1.43
database_cross_reference: AOD:0000004842
database_cross_reference: AOD:0000023175
database_cross_reference: CHV:0000007312
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0368-2390
database_cross_reference: DO:DOID:1024
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002346
database_cross_reference: ICD10:A30
database_cross_reference: ICD10:A30.9
database_cross_reference: ICD10AM:A30
database_cross_reference: ICD10AM:A30.9
database_cross_reference: ICD10CM:A30
database_cross_reference: ICD10CM:A30.9
database_cross_reference: ICD9CM:030
database_cross_reference: ICD9CM:030.9
database_cross_reference: ICPC2P:A78016
database_cross_reference: LCH:U002656
database_cross_reference: LCH_NW:sh85076084
database_cross_reference: MDR:10019138
database_cross_reference: MDR:10024229
database_cross_reference: MDR:10024230
database_cross_reference: MDR:10024231
database_cross_reference: MDR:10024232
database_cross_reference: MDR:10028451
database_cross_reference: MEDCIN:31002
database_cross_reference: MEDLINEPLUS:5360
database_cross_reference: MSH:D007918
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84824
database_cross_reference: NCI_NICHD:C84824
database_cross_reference: NDFRT:N0000001810
database_cross_reference: RCD:A30..
database_cross_reference: RCD:A30z.
database_cross_reference: RCD:Ayu31
database_cross_reference: RCDSY:Ayu31
database_cross_reference: SNM:D-0134
database_cross_reference: SNMI:DE-12300
database_cross_reference: SNOMEDCT_US:154298007
database_cross_reference: SNOMEDCT_US:186339006
database_cross_reference: SNOMEDCT_US:187316006
database_cross_reference: SNOMEDCT_US:266184007
database_cross_reference: SNOMEDCT_US:81004002

ehrlichiosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.
PMOID: PMO:00029516
Subclass_of: primary bacterial infectious disease
Synonym: E-227 EHRLICHIOSES
Synonym: EHRLICHIOSES
Synonym: EHRLICHIOSIS
Synonym: Ehrlichioses
Synonym: Ehrlichiosis
Synonym: Ehrlichiosis (disorder)
Synonym: Ehrlichiosis NOS
Synonym: Ehrlichiosis [Disease/Finding]
Synonym: Ehrlichiosis, NOS
Synonym: Ehrlichiosis, unspecified
Tree Number: T10.7.3.1.18
database_cross_reference: CHV:0000015582
database_cross_reference: CSP:4009-0003
database_cross_reference: DO:DOID:10242
database_cross_reference: DXP:U000512
database_cross_reference: ICD10CM:A77.4
database_cross_reference: ICD10CM:A77.40
database_cross_reference: ICD9CM:082.4
database_cross_reference: ICD9CM:082.40
database_cross_reference: LCH_NW:sh90000733
database_cross_reference: MEDCIN:214075
database_cross_reference: MEDLINEPLUS:1645
database_cross_reference: MSH:D016873
database_cross_reference: NDFRT:N0000003496
database_cross_reference: RCD:X70OU
database_cross_reference: SNMI:DE-22700
database_cross_reference: SNOMEDCT_US:77361002

louping ill
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection in sheep and rarely humans, has material basis in Louping ill virus, which is transmitted by sheep tick, Ixodes ricinus. The infection has symptom lethargy, has symptom muscle pains, has symptom fever, and has symptom focal neurological signs.
PMOID: PMO:00029421
Subclass_of: viral infectious disease
Synonym: Ill, Louping
Synonym: Louping Ill
Synonym: Louping Ill [Disease/Finding]
Synonym: Louping ill
Synonym: Louping ill (disorder)
Synonym: Louping ill encephalitis
Synonym: Ovine encephalomyelitis
Synonym: encephalitis due to louping ill virus
Synonym: encephalitis due to louping ill virus (diagnosis)
Synonym: louping ill viral encephalitis
Tree Number: T10.7.2.55
database_cross_reference: DO:DOID:10250
database_cross_reference: ICD10CM:A84.8
database_cross_reference: ICD9CM:063.1
database_cross_reference: LCH_NW:sh85078511
database_cross_reference: MDR:10024887
database_cross_reference: MEDCIN:36275
database_cross_reference: MSH:D008146
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001874
database_cross_reference: RCD:A631.
database_cross_reference: SNM:D-0424
database_cross_reference: SNMI:DE-33270
database_cross_reference: SNOMEDCT_US:59350003
database_cross_reference: SNOMEDCT_VET:344581000009103

strawberry gallbladder
type: Class
subclass of: gallbladder disease
PMOID: PMO:00033633
Subclass_of: gallbladder disease
Synonym: Cholesterolosis of gallbladder
Tree Number: T10.8.11.10.1
database_cross_reference: DO:DOID:10254

mumps
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in inflammation located in salivary gland, has material basis in Mumps virus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. The infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.
PMOID: PMO:00029403
Subclass_of: viral infectious disease
Synonym: Clinical mumps
Synonym: EPIDEMIC PAROTITIS
Synonym: Epidemic Parotitides
Synonym: Epidemic Parotitis
Synonym: Epidemic parotitis
Synonym: Infectious parotitis
Synonym: MUMPS
Synonym: Mumps
Synonym: Mumps (disorder)
Synonym: Mumps NOS
Tree Number: T10.7.2.46
database_cross_reference: AOD:0000004826
database_cross_reference: CHV:0000008333
database_cross_reference: COSTAR:U000450
database_cross_reference: CSP:3100-0591
database_cross_reference: DO:DOID:10264
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001219
database_cross_reference: DXP:U002668
database_cross_reference: ICD10:B26
database_cross_reference: ICD10AM:B26
database_cross_reference: ICD10CM:B26
database_cross_reference: ICD10CM:B26.9
database_cross_reference: ICD9CM:072
database_cross_reference: ICPC2EENG:D71
database_cross_reference: ICPC2P:D71003
database_cross_reference: LCH:U003056
database_cross_reference: LCH_NW:sh85088403
database_cross_reference: LNC:LA10491-1
database_cross_reference: LNC:LP32627-9
database_cross_reference: MDR:10009300
database_cross_reference: MDR:10028257
database_cross_reference: MDR:10065183
database_cross_reference: MEDCIN:31434
database_cross_reference: MEDCIN:91268
database_cross_reference: MEDCIN:91275
database_cross_reference: MEDLINEPLUS:334
database_cross_reference: MSH:D009107
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:072.9
database_cross_reference: NCI:C29888
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NICHD:C29888
database_cross_reference: NDFRT:N0000002055
database_cross_reference: RCD:A72..
database_cross_reference: RCD:X70LD
database_cross_reference: SNM:D-0433
database_cross_reference: SNMI:DE-33710
database_cross_reference: SNOMEDCT_US:154352008
database_cross_reference: SNOMEDCT_US:186651001
database_cross_reference: SNOMEDCT_US:186652008
database_cross_reference: SNOMEDCT_US:240526004
database_cross_reference: SNOMEDCT_US:36989005

heart conduction disease
type: Class
subclass of: heart disease
definition: A cardiovascular system disease that involves the heart's electrical conduction system.
PMOID: PMO:00031734
Subclass_of: heart disease
Synonym: Other heart block
Synonym: Other heart block (disorder)
Synonym: Other heart block NOS
Synonym: Other heart block NOS (disorder)
Synonym: heart rhythm disease
Tree Number: T10.8.3.2.4
database_cross_reference: DO:DOID:10273
database_cross_reference: ICD9CM:426.6
database_cross_reference: MDR:10032099
database_cross_reference: RCD:G566.
database_cross_reference: RCD:G566z
database_cross_reference: SNOMEDCT_US:195053008
database_cross_reference: SNOMEDCT_US:195056000

familial periodic paralysis
type: Class
subclass of: metal metabolism disorder
PMOID: PMO:00029012
Subclass_of: metal metabolism disorder
Synonym: Cavarre disease
Synonym: Familial Periodic Paralyses
Synonym: Familial Periodic Paralysis
Synonym: Familial myoplegia
Synonym: Familial periodic paralysis
Synonym: Familial periodic paralysis (disorder)
Synonym: Familial periodic paralysis (disorder) [Ambiguous]
Synonym: Familial periodic paralysis, NOS
Synonym: Familial periodic paralysis, primary
Synonym: Familial recurrent paralysis
Tree Number: T10.6.2.4.3
database_cross_reference: CHV:0000009271
database_cross_reference: COSTAR:U000481
database_cross_reference: CSP:1849-3266
database_cross_reference: DO:DOID:1029
database_cross_reference: ICD10CM:G72.3
database_cross_reference: MDR:10016208
database_cross_reference: MDR:10033827
database_cross_reference: MEDCIN:312652
database_cross_reference: MSH:D010245
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:359.3
database_cross_reference: NCI:C84709
database_cross_reference: NDFRT:N0000002305
database_cross_reference: RCD:XE15q
database_cross_reference: SNM:D-8045
database_cross_reference: SNMI:D6-98500
database_cross_reference: SNOMEDCT_US:155099000
database_cross_reference: SNOMEDCT_US:193241004
database_cross_reference: SNOMEDCT_US:267607008
database_cross_reference: SNOMEDCT_US:267714003
database_cross_reference: SNOMEDCT_US:54696002

viral meningitis
type: Class
subclass of: viral infectious disease
PMOID: PMO:00029448
Subclass_of: viral infectious disease
Synonym: Abacterial meningitis
Synonym: Aseptic meningitis, viral
Synonym: MENINGITIS VIRAL
Synonym: Meningitides, Viral
Synonym: Meningitis - viral NOS
Synonym: Meningitis - viral NOS (disorder)
Synonym: Meningitis viral
Synonym: Meningitis viral NOS
Synonym: Meningitis, Viral
Synonym: Meningitis, Viral [Disease/Finding]
Tree Number: T10.7.2.79
database_cross_reference: BI:BI00545
database_cross_reference: CCPSS:1004364
database_cross_reference: CHV:0000007938
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2042-5450
database_cross_reference: DO:DOID:10310
database_cross_reference: ICD10:A87
database_cross_reference: ICD10:A87.9
database_cross_reference: ICD10AM:A87
database_cross_reference: ICD10AM:A87.9
database_cross_reference: ICD10CM:A87
database_cross_reference: ICD10CM:A87.9
database_cross_reference: ICD9CM:047.9
database_cross_reference: MDR:10027260
database_cross_reference: MDR:10027262
database_cross_reference: MDR:10046236
database_cross_reference: MDR:10047469
database_cross_reference: MEDCIN:35668
database_cross_reference: MSH:D008587
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:047.9
database_cross_reference: NCI:C118298
database_cross_reference: NCI_NICHD:C118298
database_cross_reference: NDFRT:N0000001987
database_cross_reference: RCD:Ayu8D
database_cross_reference: RCD:XE0R7
database_cross_reference: RCD:XE15A
database_cross_reference: RCD:Xa9B5
database_cross_reference: RCDSY:Ayu8D
database_cross_reference: SNM:D-0500
database_cross_reference: SNMI:DE-30020
database_cross_reference: SNOMEDCT_US:154321007
database_cross_reference: SNOMEDCT_US:154984006
database_cross_reference: SNOMEDCT_US:154985007
database_cross_reference: SNOMEDCT_US:186490006
database_cross_reference: SNOMEDCT_US:187403007
database_cross_reference: SNOMEDCT_US:192672003
database_cross_reference: SNOMEDCT_US:266097006
database_cross_reference: SNOMEDCT_US:266190006
database_cross_reference: SNOMEDCT_US:267575007
database_cross_reference: SNOMEDCT_US:267680008
database_cross_reference: SNOMEDCT_US:58170007

yaws
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results in infection located in skin, located in joint or located in bone, has material basis in Treponema pallidum subsp pertenue, which is transmitted by direct skin contact with an infected person. The infection has symptom skin lesions.
PMOID: PMO:00029590
Subclass_of: primary bacterial infectious disease
Synonym: BOUBA
Synonym: Bouba
Synonym: Buba
Synonym: E-155 YAWS
Synonym: FRAMBESIA
Synonym: Frambesia
Synonym: Frambesia Tropica
Synonym: Frambesia Tropicas
Synonym: Frambesias
Synonym: Framboesia
Tree Number: T10.7.3.1.42
database_cross_reference: CCPSS:0053786
database_cross_reference: CHV:0000013247
database_cross_reference: CSP:0368-3371
database_cross_reference: DO:DOID:10371
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002034
database_cross_reference: ICD10:A66
database_cross_reference: ICD10:A66.9
database_cross_reference: ICD10AM:A66
database_cross_reference: ICD10AM:A66.9
database_cross_reference: ICD10CM:A66
database_cross_reference: ICD10CM:A66.9
database_cross_reference: ICD9CM:102
database_cross_reference: ICD9CM:102.9
database_cross_reference: ICPC2P:A78028
database_cross_reference: LCH:U005069
database_cross_reference: LCH_NW:sh85149048
database_cross_reference: MDR:10048234
database_cross_reference: MDR:10048237
database_cross_reference: MEDCIN:31083
database_cross_reference: MSH:D015001
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C41353
database_cross_reference: NDFRT:N0000003181
database_cross_reference: RCD:AA2..
database_cross_reference: RCD:AA2z.
database_cross_reference: RCD:Ayu52
database_cross_reference: RCDAE:AA2..
database_cross_reference: RCDSY:Ayu52
database_cross_reference: SNM:D-0200
database_cross_reference: SNMI:DE-15500
database_cross_reference: SNOMEDCT_US:154391003
database_cross_reference: SNOMEDCT_US:186974004
database_cross_reference: SNOMEDCT_US:187372000
database_cross_reference: SNOMEDCT_US:266213004
database_cross_reference: SNOMEDCT_US:70647001

bacterial infectious disease
type: Class
subclass of: disease by infectious agent
definition: A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.
PMOID: PMO:00029458
Subclass_of: disease by infectious agent
Synonym: BACT INFECT
Synonym: BACTERIAL INFECTION
Synonym: BACTERIAL INFECTIOUS DISEASES
Synonym: BACTERIAL INFECTIOUS DISEASES: GENERAL TERMS
Synonym: Bacterial Disease
Synonym: Bacterial Disorder
Synonym: Bacterial Disorders
Synonym: Bacterial Infection
Synonym: Bacterial Infections
Synonym: Bacterial Infections [Disease/Finding]
Tree Number: T10.7.3
database_cross_reference: AOD:0000004834
database_cross_reference: BI:BI00702
database_cross_reference: CCPSS:0036503
database_cross_reference: CHV:0000001669
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0368-2318
database_cross_reference: CST:INFECT BACT
database_cross_reference: DO:DOID:104
database_cross_reference: ICD10:A49
database_cross_reference: ICD10:A49.9
database_cross_reference: ICD10AM:A49
database_cross_reference: ICD10AM:A49.9
database_cross_reference: ICD10CM:A49
database_cross_reference: ICD10CM:A49.9
database_cross_reference: ICPC2P:A78005
database_cross_reference: LCH_NW:sh85010843
database_cross_reference: MDR:10004018
database_cross_reference: MDR:10004044
database_cross_reference: MDR:10021804
database_cross_reference: MDR:10060945
database_cross_reference: MEDCIN:361217
database_cross_reference: MEDCIN:90184
database_cross_reference: MEDLINEPLUS:158
database_cross_reference: MSH:D001424
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2890
database_cross_reference: NCI_FDA:1735
database_cross_reference: NCI_NICHD:C2890
database_cross_reference: NDFRT:N0000000524
database_cross_reference: OMIM:MTHU054518
database_cross_reference: PSY:05300
database_cross_reference: RCD:Ayu3X
database_cross_reference: RCD:X70Gv
database_cross_reference: RCD:XE0TG
database_cross_reference: RCD:Xa85o
database_cross_reference: RCDSY:Ayu3X
database_cross_reference: SNM:D-0110
database_cross_reference: SNM:U000001
database_cross_reference: SNMI:DE-10000
database_cross_reference: SNOMEDCT_US:154318005
database_cross_reference: SNOMEDCT_US:186470002
database_cross_reference: SNOMEDCT_US:187347000
database_cross_reference: SNOMEDCT_US:266182006
database_cross_reference: SNOMEDCT_US:266187000
database_cross_reference: SNOMEDCT_US:301811001
database_cross_reference: SNOMEDCT_US:87628006

Klippel-Feil syndrome
type: Class
subclass of: physical disorder
definition: A physical disorder that has material basis in abnormal segmentation of the vertebra during fetal development which results in fusion located in cervical vertebra.
PMOID: PMO:00028263
Subclass_of: physical disorder
Synonym: BREVICOLLIS
Synonym: Bonnevie-Ullrich and Klippel-Feil syndrome
Synonym: CERVICAL VERTEBRA FUSION
Synonym: Cervical C2/C3 vertebral fusion
Synonym: Cervical Fusion Syndrome
Synonym: Cervical fusion syndrome
Synonym: Cervical vertebral fusion
Synonym: Cervical vertebral fusion syndrome
Synonym: Cervical-vertebral fusion
Synonym: Congenital dystrophia brevicollis
Tree Number: T10.4.9
database_cross_reference: CHV:0000007122
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10426
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000641
database_cross_reference: DXP:U000994
database_cross_reference: HPO:HP:0004602
database_cross_reference: ICD10:Q76.1
database_cross_reference: ICD10AM:Q76.1
database_cross_reference: ICD10CM:Q76.1
database_cross_reference: ICD9CM:756.16
database_cross_reference: MDR:10023464
database_cross_reference: MEDCIN:32235
database_cross_reference: MSH:D007714
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98967
database_cross_reference: NCI_NICHD:C98967
database_cross_reference: NDFRT:N0000001760
database_cross_reference: RCD:PG16.
database_cross_reference: RCD:PG16z
database_cross_reference: SNM:D-5029
database_cross_reference: SNM:D-5324
database_cross_reference: SNM:M-20200
database_cross_reference: SNMI:D4-01537
database_cross_reference: SNOMEDCT_US:129581007
database_cross_reference: SNOMEDCT_US:157003009
database_cross_reference: SNOMEDCT_US:205441002
database_cross_reference: SNOMEDCT_US:268349005
database_cross_reference: SNOMEDCT_US:388981000
database_cross_reference: SNOMEDCT_US:5601008

tonsillitis
type: Class
subclass of: upper respiratory tract disease
definition: An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.
PMOID: PMO:00032481
Subclass_of: upper respiratory tract disease
Synonym: Inflammation of tonsil
Synonym: Inflammation of tonsils
Synonym: Inflammation;tonsils
Synonym: TONSILLITIS
Synonym: Throat infection - tonsillitis
Synonym: Tonsillar inflammation
Synonym: Tonsillitides
Synonym: Tonsillitis
Synonym: Tonsillitis (disorder)
Synonym: Tonsillitis NOS
Tree Number: T10.8.5.2.2
database_cross_reference: CCPSS:1013382
database_cross_reference: CHV:0000012362
database_cross_reference: CHV:0000049949
database_cross_reference: COSTAR:U000679
database_cross_reference: CST:PHARYNGITIS
database_cross_reference: DO:DOID:10456
database_cross_reference: DXP:U004087
database_cross_reference: HPO:HP:0011110
database_cross_reference: ICPC2P:R21013
database_cross_reference: ICPC2P:R22002
database_cross_reference: ICPC2P:R76003
database_cross_reference: LCH:U004721
database_cross_reference: LCH_NW:sh85136023
database_cross_reference: MDR:10044008
database_cross_reference: MDR:10044011
database_cross_reference: MDR:10065169
database_cross_reference: MEDCIN:31373
database_cross_reference: MEDLINEPLUS:1515
database_cross_reference: MSH:D014069
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:463
database_cross_reference: NCI:C116006
database_cross_reference: NCI_NICHD:C116006
database_cross_reference: NDFRT:N0000002969
database_cross_reference: RCD:Xa7I0
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:DC-71200
database_cross_reference: SNOMEDCT_US:195665006
database_cross_reference: SNOMEDCT_US:90176007
database_cross_reference: SNOMEDCT_VET:90176007

legionellosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.
PMOID: PMO:00029520
Subclass_of: primary bacterial infectious disease
Synonym: E-157 LEGIONELLA INFECTIONS
Synonym: LEGIONELLA INFECTIONS
Synonym: Legionella infection
Synonym: Legionella infection (disorder)
Synonym: Legionella infection NOS
Synonym: Legionella infection, NOS
Synonym: Legionella infections
Synonym: Legionelloses
Synonym: Legionellosis
Synonym: Legionellosis [Disease/Finding]
Tree Number: T10.7.3.1.20
database_cross_reference: CHV:0000007280
database_cross_reference: CSP:0368-3108
database_cross_reference: DO:DOID:10458
database_cross_reference: LNC:LA10483-8
database_cross_reference: MDR:10024179
database_cross_reference: MDR:10050919
database_cross_reference: MDR:10061266
database_cross_reference: MEDLINEPLUS:1526
database_cross_reference: MSH:D007876
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C128334
database_cross_reference: NCI_NICHD:C128334
database_cross_reference: NDFRT:N0000001799
database_cross_reference: RCD:XE2uE
database_cross_reference: SNMI:DE-15700
database_cross_reference: SNOMEDCT_US:26726000

common cold
type: Class
subclass of: upper respiratory tract disease
definition: An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.
PMOID: PMO:00032498
Subclass_of: upper respiratory tract disease
Synonym: (Acute nasopharyngitis or rhinitis) or (common cold)
Synonym: (Acute nasopharyngitis or rhinitis) or (common cold) (disorder)
Synonym: Acute Nasopharyngitis
Synonym: Acute coryza
Synonym: Acute infective rhinitis
Synonym: Acute nasal catarrh
Synonym: Acute nasopharyngitis
Synonym: Acute nasopharyngitis (common cold)
Synonym: Acute nasopharyngitis [common cold]
Synonym: Acute nasopharyngitis, NOS
Tree Number: T10.8.5.2.9
database_cross_reference: AOD:0000004799
database_cross_reference: CCPSS:0015726
database_cross_reference: CCPSS:0035226
database_cross_reference: CCPSS:0041836
database_cross_reference: CCPSS:0059528
database_cross_reference: CHV:0000003199
database_cross_reference: CHV:0000012744
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:3099-9293
database_cross_reference: CST:INFECT
database_cross_reference: DO:DOID:10459
database_cross_reference: DRUGBANK:DB00316
database_cross_reference: DRUGBANK:DB00388
database_cross_reference: DRUGBANK:DB00514
database_cross_reference: DRUGBANK:DB01114
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000388
database_cross_reference: DXP:U000875
database_cross_reference: ICD10:J00
database_cross_reference: ICD10AM:J00
database_cross_reference: ICD10CM:J00
database_cross_reference: ICD9CM:460
database_cross_reference: ICPC2EENG:R74
database_cross_reference: ICPC2P:R74003
database_cross_reference: ICPC2P:R74004
database_cross_reference: ICPC2P:R74010
database_cross_reference: ICPC2P:R74012
database_cross_reference: LCH:U005392
database_cross_reference: LCH_NW:sh85027912
database_cross_reference: MDR:10000937
database_cross_reference: MDR:10000938
database_cross_reference: MDR:10009851
database_cross_reference: MDR:10010106
database_cross_reference: MDR:10010107
database_cross_reference: MDR:10019192
database_cross_reference: MDR:10021921
database_cross_reference: MDR:10039084
database_cross_reference: MDR:10059827
database_cross_reference: MDR:10066743
database_cross_reference: MEDCIN:31071
database_cross_reference: MEDCIN:312332
database_cross_reference: MEDCIN:313652
database_cross_reference: MEDCIN:350019
database_cross_reference: MEDCIN:363081
database_cross_reference: MEDLINEPLUS:196
database_cross_reference: MSH:D003139
database_cross_reference: MTH:210
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:460
database_cross_reference: NCI:C34500
database_cross_reference: NCI:C78599
database_cross_reference: NCI_CTCAE:E11548
database_cross_reference: NCI_NICHD:C78599
database_cross_reference: NDFRT:N0000000824
database_cross_reference: RCD:X00kv
database_cross_reference: RCD:XE0Xl
database_cross_reference: SNM:D-0374
database_cross_reference: SNM:D-7505
database_cross_reference: SNMI:D2-00020
database_cross_reference: SNMI:DE-35210
database_cross_reference: SNOMEDCT_US:155497009
database_cross_reference: SNOMEDCT_US:195648002
database_cross_reference: SNOMEDCT_US:232341009
database_cross_reference: SNOMEDCT_US:232342002

diaphragm disease
type: Class
subclass of: muscular disease
definition: A muscular disease that is located_in the diaphragm.
PMOID: PMO:00032451
Subclass_of: muscular disease
Synonym: 2-82 DISEASES OF THE DIAPHRAGM
Synonym: DISEASES OF THE DIAPHRAGM
Synonym: Diaphragm
Synonym: Diaphragmatic disease
Synonym: Diaphragmatic disorder
Synonym: Diaphragmatic disorder NOS
Synonym: Diaphragmatic disorders
Synonym: Diaphragmatic disorders (diagnosis)
Synonym: Disease of diaphragm
Synonym: Disease of diaphragm (disorder)
Tree Number: T10.8.4.3.2
database_cross_reference: CHV:0000017167
database_cross_reference: CST:RES/DPRM
database_cross_reference: DO:DOID:10481
database_cross_reference: ICD10:J98.6
database_cross_reference: ICD10AM:J98.6
database_cross_reference: ICD10CM:J98.6
database_cross_reference: ICD9CM:519.4
database_cross_reference: MDR:10012706
database_cross_reference: MDR:10012712
database_cross_reference: MDR:10013304
database_cross_reference: MDR:10061106
database_cross_reference: MEDCIN:314875
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:H5y4.
database_cross_reference: RCD:H5y4z
database_cross_reference: SNM:D-6150
database_cross_reference: SNMI:D2-82000
database_cross_reference: SNOMEDCT_US:196182001
database_cross_reference: SNOMEDCT_US:48475001

esophageal atresia
type: Class
subclass of: esophageal disease
PMOID: PMO:00033439
Subclass_of: esophageal disease
Synonym: ATRESIA ESOPHAGUS
Synonym: Atresia esophagus
Synonym: Atresia oesophagus
Synonym: Atresia of esophagus
Synonym: Atresia of esophagus NOS
Synonym: Atresia of oesophagus
Synonym: Atresia, Esophageal
Synonym: Atresias, Esophageal
Synonym: Congenital Atresia of Esophagus
Synonym: Congenital Esophageal Atresia
Tree Number: T10.8.11.2.1
database_cross_reference: CHV:0000004648
database_cross_reference: CSP:0724-7089
database_cross_reference: CSP:1248-5440
database_cross_reference: CST:STENO ESOPH
database_cross_reference: DO:DOID:10485
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0002032
database_cross_reference: ICD10CM:Q39.0
database_cross_reference: LCH_NW:sh85044857
database_cross_reference: MDR:10003651
database_cross_reference: MDR:10003652
database_cross_reference: MDR:10014964
database_cross_reference: MDR:10015471
database_cross_reference: MDR:10021530
database_cross_reference: MDR:10030146
database_cross_reference: MDR:10055460
database_cross_reference: MDR:10055495
database_cross_reference: MDR:10056097
database_cross_reference: MDR:10072767
database_cross_reference: MDR:10072768
database_cross_reference: MSH:D004933
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:750.3
database_cross_reference: NCI:C87072
database_cross_reference: NCI_NICHD:C87072
database_cross_reference: NDFRT:N0000001157
database_cross_reference: OMIM:MTHU011564
database_cross_reference: RCD:PA30.
database_cross_reference: RCD:PA33.
database_cross_reference: RCDAE:PA30.
database_cross_reference: RCDAE:PA33.
database_cross_reference: SNMI:D4-55002
database_cross_reference: SNOMEDCT_US:156947007
database_cross_reference: SNOMEDCT_US:204656005
database_cross_reference: SNOMEDCT_US:26179002

intestinal atresia
type: Class
subclass of: intestinal disease
PMOID: PMO:00033544
Subclass_of: intestinal disease
Synonym: Congenital absence, atresia and stenosis of jejunum
Tree Number: T10.8.11.8.9
database_cross_reference: DO:DOID:10486
database_cross_reference: ICD10:Q41.1
database_cross_reference: ICD10AM:Q41.1
database_cross_reference: ICD10CM:Q41.1

imperforate anus
type: Class
subclass of: physical disorder
PMOID: PMO:00028258
Subclass_of: physical disorder
Synonym: ANAL IMPERFORATION
Synonym: ANUS IMPERFORATE
Synonym: ANUS, IMPERFORATE
Synonym: Anal Atresia
Synonym: Anal Atresias
Synonym: Anal atresia
Synonym: Anal atresia (disorder)
Synonym: Anus imperforate
Synonym: Anus, Imperforate
Synonym: Anus, Imperforate [Disease/Finding]
Tree Number: T10.4.4
database_cross_reference: CCPSS:0050636
database_cross_reference: CHV:0000001341
database_cross_reference: CST:ANUS IMPERFOR
database_cross_reference: DO:DOID:10488
database_cross_reference: DXP:U000161
database_cross_reference: HPO:HP:0002023
database_cross_reference: ICD10CM:Q42.3
database_cross_reference: ICPC2P:D81012
database_cross_reference: MDR:10002120
database_cross_reference: MDR:10002853
database_cross_reference: MDR:10010330
database_cross_reference: MDR:10021528
database_cross_reference: MEDCIN:263358
database_cross_reference: MEDCIN:362043
database_cross_reference: MSH:D001006
database_cross_reference: MTHICD9:751.2
database_cross_reference: NCI:C84784
database_cross_reference: NCI_CDISC:C84784
database_cross_reference: NCI_NICHD:C84784
database_cross_reference: NDFRT:N0000000434
database_cross_reference: OMIM:207500
database_cross_reference: OMIM:301800
database_cross_reference: OMIM:MTHU001447
database_cross_reference: OMIM:MTHU005779
database_cross_reference: RCD:PB210
database_cross_reference: RCD:PB26.
database_cross_reference: RCD:PB26z
database_cross_reference: SNM:M-26900
database_cross_reference: SNMI:D4-56912
database_cross_reference: SNOMEDCT_US:14118000
database_cross_reference: SNOMEDCT_US:156956004
database_cross_reference: SNOMEDCT_US:204712000
database_cross_reference: SNOMEDCT_US:204731006
database_cross_reference: SNOMEDCT_US:204733009

viral pneumonia
type: Class
subclass of: viral infectious disease
definition: A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus.
PMOID: PMO:00029382
Subclass_of: viral infectious disease
Synonym: Chest infection - viral pneumonia
Synonym: PNEUMONIA VIRAL
Synonym: PNEUMONIA, ABACTERIAL
Synonym: PNEUMONIA, VIRAL
Synonym: Pneumonia viral
Synonym: Pneumonia viral NOS
Synonym: Pneumonia, Viral
Synonym: Pneumonia, Viral [Disease/Finding]
Synonym: Pneumonia, viral
Synonym: Pneumonia;viral
Tree Number: T10.7.2.32
database_cross_reference: BI:BI00190
database_cross_reference: CCPSS:1014257
database_cross_reference: CHV:0000009875
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000616
database_cross_reference: CSP:2596-6474
database_cross_reference: DO:DOID:10533
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001537
database_cross_reference: ICD10:J12.9
database_cross_reference: ICD10AM:J12.9
database_cross_reference: ICD10CM:J12.9
database_cross_reference: ICD9CM:480
database_cross_reference: ICD9CM:480.9
database_cross_reference: ICPC2P:R81005
database_cross_reference: LCH:U004953
database_cross_reference: LCH_NW:sh85143733
database_cross_reference: MDR:10035737
database_cross_reference: MDR:10035738
database_cross_reference: MDR:10047474
database_cross_reference: MDR:10047475
database_cross_reference: MDR:10076502
database_cross_reference: MEDCIN:31270
database_cross_reference: MSH:D011024
database_cross_reference: NDFRT:N0000002441
database_cross_reference: RCD:H20z.
database_cross_reference: RCD:XE0YG
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:DE-30015
database_cross_reference: SNOMEDCT_US:155549005
database_cross_reference: SNOMEDCT_US:195880002
database_cross_reference: SNOMEDCT_US:195883000
database_cross_reference: SNOMEDCT_US:75570004

meningoencephalitis
type: Class
subclass of: central nervous system disease
definition: A central nervous system disease that involves encephalitis which occurs along with meningitis.
PMOID: PMO:00030464
Subclass_of: central nervous system disease
Synonym: Cerebromeningitides
Synonym: Cerebromeningitis
Synonym: Encephalomeningitides
Synonym: Encephalomeningitis
Synonym: MENINGOENCEPH
Synonym: MENINGOENCEPHALITIS
Synonym: Meningoencephalitides
Synonym: Meningoencephalitis
Synonym: Meningoencephalitis (disorder)
Synonym: Meningoencephalitis [Disease/Finding]
Tree Number: T10.8.2.9.5
database_cross_reference: CCPSS:0014556
database_cross_reference: CHV:0000007942
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:ENCEPHALITIS
database_cross_reference: DO:DOID:10554
database_cross_reference: DXP:U002545
database_cross_reference: ICD10CM:A69.22
database_cross_reference: ICD10CM:G04
database_cross_reference: LCH:U002902
database_cross_reference: LCH_NW:sh85083569
database_cross_reference: MDR:10027282
database_cross_reference: MEDCIN:336269
database_cross_reference: MSH:D008590
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34813
database_cross_reference: NCI_NICHD:C34813
database_cross_reference: NDFRT:N0000001990
database_cross_reference: OMIM:MTHU037268
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:DA-10135
database_cross_reference: SNOMEDCT_US:7125002

supine hypotensive syndrome
type: Class
subclass of: vascular disease
definition: A vascular disease that is characterized by severe supine hypotension in late pregnancy, whose clinical presentation ranges from minimal cardiovascular alterations to severe shock, resulting from inferior vena cava compression by gravid uterus.
PMOID: PMO:00031823
Subclass_of: vascular disease
Synonym: Matern hypotens syn-unsp
Synonym: Maternal hypotension syndrome complicating labor and delivery, unspecified as to episode of care
Synonym: Maternal hypotension syndrome, unspecified as to episode of care or not applicable
Synonym: antepartum maternal hypotension syndrome
Synonym: postpartum maternal hypotension syndrome
Tree Number: T10.8.3.3.1
database_cross_reference: DO:DOID:10556
database_cross_reference: ICD9CM:669.20
database_cross_reference: MDR:10026927
database_cross_reference: MTHICD9:669.20

oculocerebrorenal syndrome
type: Class
subclass of: X-linked disease
PMOID: PMO:00028731
Subclass_of: X-linked disease
Synonym: Cerebro Oculo Renal Syndrome
Synonym: Cerebro-Oculo-Renal Syndrome
Synonym: Cerebro-oculorenal dystrophy
Synonym: Cerebrooculorenal Syndrome
Synonym: Dystrophy, Oculocerebrorenal
Synonym: LOWE DIS
Synonym: LOWE OCULOCEREBRORENAL SYNDROME
Synonym: LOWE SYNDROME
Synonym: Lowe Bickel Syndrome
Synonym: Lowe Disease
Tree Number: T10.5.3.4.11
database_cross_reference: CHV:0000008898
database_cross_reference: CSP:1849-1861
database_cross_reference: DO:DOID:1056
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001312
database_cross_reference: ICD10CM:E72.03
database_cross_reference: JABL:401
database_cross_reference: LCH_NW:sh87005152
database_cross_reference: MDR:10051707
database_cross_reference: MDR:10051754
database_cross_reference: MEDCIN:32384
database_cross_reference: MSH:D009800
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84940
database_cross_reference: NCI_NICHD:C84940
database_cross_reference: NDFRT:N0000002208
database_cross_reference: OMIM:300535
database_cross_reference: OMIM:309000
database_cross_reference: RCD:C3025
database_cross_reference: SNM:D-5084
database_cross_reference: SNMI:D4-00618
database_cross_reference: SNOMEDCT_US:79385002

calcium metabolism disease
type: Class
subclass of: mineral metabolism disease
definition: A hypercalcemia characterized byautosomal dominant inheritance with elevation of serum calcium levels and decreased urinary calcium excretion.
PMOID: PMO:00028931
Subclass_of: mineral metabolism disease
Synonym: CALCIUM METAB DIS
Synonym: CALCIUM METABOLISM DISORDER
Synonym: Calcium Metabolism Disorder
Synonym: Calcium Metabolism Disorders
Synonym: Calcium Metabolism Disorders [Disease/Finding]
Synonym: Calcium metabolism disorder
Synonym: Calcium metabolism disorders
Synonym: Calcium--Metabolism--Disorders
Synonym: Dis calcium metablsm NOS
Synonym: Disorder of calcium metab NOS
Tree Number: T10.6.1.5.4
database_cross_reference: AOD:0000005776
database_cross_reference: AOD:0000023461
database_cross_reference: CCPSS:0031658
database_cross_reference: CHV:0000002302
database_cross_reference: CSP:0531-6510
database_cross_reference: DO:DOID:0060699
database_cross_reference: DO:DOID:10575
database_cross_reference: ICD10:E83.5
database_cross_reference: ICD10AM:E83.5
database_cross_reference: ICD10CM:E83.5
database_cross_reference: ICD10CM:E83.50
database_cross_reference: ICD9CM:275.4
database_cross_reference: ICD9CM:275.40
database_cross_reference: LCH_NW:sh85018773
database_cross_reference: MDR:10006974
database_cross_reference: MDR:10006975
database_cross_reference: MDR:10013299
database_cross_reference: MEDCIN:337578
database_cross_reference: MSH:D002128
database_cross_reference: NDFRT:N0000000646
database_cross_reference: RCD:C354z
database_cross_reference: RCD:XE11d
database_cross_reference: SNMI:D6-34600
database_cross_reference: SNOMEDCT_US:190863003
database_cross_reference: SNOMEDCT_US:190874007
database_cross_reference: SNOMEDCT_US:267442002
database_cross_reference: SNOMEDCT_US:71638002

Refsum disease
type: Class
subclass of: lipid metabolism disorder
PMOID: PMO:00029258
Subclass_of: lipid metabolism disorder
Synonym: Adult Refsum Disease
Synonym: Adult Refsum Diseases
Synonym: Classic Refsum Disease
Synonym: Classic Refsum Diseases
Synonym: Disease, Adult Refsum
Synonym: Disease, Classic Refsum
Synonym: Disease, Refsum
Synonym: Disease, Refsum's
Synonym: Diseases, Adult Refsum
Synonym: Diseases, Classic Refsum
Tree Number: T10.6.2.18.5
database_cross_reference: CHV:0000010682
database_cross_reference: CSP:2042-7949
database_cross_reference: DO:DOID:10582
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001656
database_cross_reference: ICD10:G60.1
database_cross_reference: ICD10AM:G60.1
database_cross_reference: ICD10CM:G60.1
database_cross_reference: ICD9CM:356.3
database_cross_reference: MDR:10034999
database_cross_reference: MDR:10038275
database_cross_reference: MEDCIN:32304
database_cross_reference: MSH:D012035
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:356.3
database_cross_reference: NCI:C85043
database_cross_reference: NDFRT:N0000002588
database_cross_reference: OMIM:266500
database_cross_reference: RCD:F363.
database_cross_reference: SNM:D-8X94
database_cross_reference: SNMI:D6-B7200
database_cross_reference: SNOMEDCT_US:25362006

intellectual disability
type: Class
subclass of: specific developmental disorder
PMOID: PMO:00028007
Subclass_of: specific developmental disorder
Synonym: Development Disorder, Intellectual
Synonym: Development Disorders, Intellectual
Synonym: Disabilities, Intellectual
Synonym: Disability, Intellectual
Synonym: Disability;intellectual
Synonym: Disorder, Intellectual Development
Synonym: Disorders, Intellectual Development
Synonym: INTELLECTUAL DISABILITIES
Synonym: Intellectual Development Disorder
Synonym: Intellectual Development Disorders
Tree Number: T10.3.5.1.10
database_cross_reference: CHV:0000036317
database_cross_reference: HPO:HP:0001249
database_cross_reference: ICD9CM:317-319.99
database_cross_reference: ICPC2P:P28005
database_cross_reference: MDR:10067989
database_cross_reference: MDR:10077548
database_cross_reference: MDR:10078089
database_cross_reference: MEDCIN:32639
database_cross_reference: MEDCIN:3549
database_cross_reference: MSH:D008607
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C97250
database_cross_reference: NCI_NICHD:C97250
database_cross_reference: NDFRT:N0000001995
database_cross_reference: OMIM:MTHU008294
database_cross_reference: OMIM:MTHU035437
database_cross_reference: RCD:Ub0ih
database_cross_reference: SNOMEDCT_US:110359009
database_cross_reference: SNOMEDCT_US:1855002
database_cross_reference: SNOMEDCT_US:228156007

Hartnup disease
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that is caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum.
PMOID: PMO:00029186
Subclass_of: amino acid metabolic disorder
Synonym: AA TRANSPORT DIS NEUTRAL
Synonym: Amino Acid Transport Disorder, Neutral
Synonym: Deficiency of tryptophan 2,3-dioxygenase
Synonym: Deficiency of tryptophan 2,3-dioxygenase (disorder)
Synonym: Deficiency of tryptophan oxygenase
Synonym: Deficiency of tryptophan pyrrolase
Synonym: H DISEASE
Synonym: HART SYNDROME
Synonym: HARTNUP DIS
Synonym: HARTNUP DISEASE
Tree Number: T10.6.2.15.9
database_cross_reference: AOD:0000005741
database_cross_reference: CHV:0000005805
database_cross_reference: CSP:1849-4235
database_cross_reference: DO:DOID:1060
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000768
database_cross_reference: ICD10CM:E72.02
database_cross_reference: MDR:10019165
database_cross_reference: MEDCIN:33620
database_cross_reference: MSH:D006250
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:270.0
database_cross_reference: NCI:C84748
database_cross_reference: NCI_NICHD:C84748
database_cross_reference: NDFRT:N0000001414
database_cross_reference: OMIM:234500
database_cross_reference: OMIM:608893
database_cross_reference: RCD:C3004
database_cross_reference: SNM:D-1740
database_cross_reference: SNMI:D6-B8400
database_cross_reference: SNOMEDCT_US:124208000
database_cross_reference: SNOMEDCT_US:80902009

steatorrhea
type: Class
subclass of: intestinal disease
PMOID: PMO:00033597
Subclass_of: intestinal disease
Synonym: (Chronic steatorrhea) or (malabsorption due to intolerance to fat)
Synonym: (Chronic steatorrhoea) or (malabsorption due to intolerance to fat)
Synonym: (Chronic steatorrhoea) or (malabsorption due to intolerance to fat) (disorder)
Synonym: Fatty stool
Tree Number: T10.8.11.8.16
database_cross_reference: DO:DOID:10602
database_cross_reference: SNOMEDCT_US:197489007

lactose intolerance
type: Class
subclass of: carbohydrate metabolic disorder
PMOID: PMO:00029132
Subclass_of: carbohydrate metabolic disorder
Synonym: Alactasia
Synonym: Cow's milk enteropathy
Synonym: Cows milk enteropathy
Synonym: Dairy Product Intolerance
Synonym: Dairy product intolerance
Synonym: Hypolactasia
Synonym: INTOLERANCE LACTOSE
Synonym: Intolerance or malabsorption of lactose
Synonym: Intolerance, Lactose
Synonym: Intolerance;lactose
Tree Number: T10.6.2.11.10
database_cross_reference: BI:BI00278
database_cross_reference: CCPSS:0047658
database_cross_reference: CHV:0000007192
database_cross_reference: COSTAR:443
database_cross_reference: COSTAR:U000416
database_cross_reference: CSP:0551-8201
database_cross_reference: CST:GI DIS
database_cross_reference: DO:DOID:10604
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001002
database_cross_reference: HPO:HP:0004789
database_cross_reference: ICD10:E73
database_cross_reference: ICD10:E73.9
database_cross_reference: ICD10AM:E73
database_cross_reference: ICD10AM:E73.9
database_cross_reference: ICD10CM:E73
database_cross_reference: ICD10CM:E73.9
database_cross_reference: ICPC2P:D99054
database_cross_reference: LCH:U002611
database_cross_reference: LCH_NW:sh85073873
database_cross_reference: MDR:10001545
database_cross_reference: MDR:10023681
database_cross_reference: MEDLINEPLUS:898
database_cross_reference: MSH:D007787
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:271.3
database_cross_reference: NCI:C3154
database_cross_reference: NCI_NCI-GLOSS:CDR0000045745
database_cross_reference: NDFRT:N0000001777
database_cross_reference: RCD:XE11K
database_cross_reference: SNOMEDCT_US:154736007
database_cross_reference: SNOMEDCT_US:190750000
database_cross_reference: SNOMEDCT_US:190757002
database_cross_reference: SNOMEDCT_US:267425008
database_cross_reference: SNOMEDCT_US:267497007
database_cross_reference: SNOMEDCT_US:700094005

short bowel syndrome
type: Class
subclass of: intestinal disease
PMOID: PMO:00033529
Subclass_of: intestinal disease
Synonym: Acquired short bowel syndrome
Synonym: Acquired short bowel syndrome (disorder)
Synonym: BOWEL SHORT BOWEL SYNDROME
Synonym: Bowel Syndrome, Short
Synonym: Bowel Syndromes, Short
Synonym: MASSIVE BOWEL RESECTION SYNDROME
Synonym: Post-resection malabsorption
Synonym: Postresectional malabsorption syndrome
Synonym: SBS - Short bowel syndrome
Synonym: SGS - Short gut syndrome
Tree Number: T10.8.11.8.3
database_cross_reference: CCPSS:0012561
database_cross_reference: CCPSS:0019899
database_cross_reference: CHV:0000011308
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0724-8009
database_cross_reference: DO:DOID:10605
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001736
database_cross_reference: MDR:10049416
database_cross_reference: MEDCIN:30201
database_cross_reference: MSH:D012778
database_cross_reference: NCI:C99059
database_cross_reference: NCI_NICHD:C99059
database_cross_reference: NDFRT:N0000002734
database_cross_reference: OMIM:MTHU014402
database_cross_reference: RCD:X303G
database_cross_reference: RCD:X303H
database_cross_reference: SNM:D-6228
database_cross_reference: SNMI:D5-47780
database_cross_reference: SNOMEDCT_US:204768009
database_cross_reference: SNOMEDCT_US:235724004
database_cross_reference: SNOMEDCT_US:26629001

blind loop syndrome
type: Class
subclass of: intestinal disease
definition: An intestinal disease characterized by a dysbalance of the bacterial flora of the small intestine, causing derangement to the normal physiological processes of digestion and absorption.
PMOID: PMO:00033622
Subclass_of: intestinal disease
Synonym: BLIND LOOP SYNDROME
Synonym: Bacterial Overgrowth Syndrome
Synonym: Bacterial overgrowth syndrome
Synonym: Bacterial overgrowth syndrome (disorder)
Synonym: Blind Loop Syndrome
Synonym: Blind Loop Syndrome [Disease/Finding]
Synonym: Blind loop syndrome
Synonym: Blind loop syndrome (disorder)
Synonym: Blind loop syndrome NOS
Synonym: Blind loop syndrome, NOS
Tree Number: T10.8.11.8.24
database_cross_reference: CHV:0000001976
database_cross_reference: CHV:0000050107
database_cross_reference: DO:DOID:10606
database_cross_reference: DXP:U000227
database_cross_reference: ICD10CM:K90.2
database_cross_reference: ICD9CM:579.2
database_cross_reference: ICPC2P:D99029
database_cross_reference: LCH:U000607
database_cross_reference: LCH_NW:sh85014884
database_cross_reference: MDR:10005166
database_cross_reference: MDR:10041904
database_cross_reference: MDR:10041956
database_cross_reference: MEDCIN:30200
database_cross_reference: MSH:D001765
database_cross_reference: NCI:C34431
database_cross_reference: NDFRT:N0000000572
database_cross_reference: RCD:J692.
database_cross_reference: SNMI:D5-44462
database_cross_reference: SNMI:D5-47300
database_cross_reference: SNOMEDCT_US:66379009
database_cross_reference: SNOMEDCT_US:77225009

tropical sprue
type: Class
subclass of: intestinal disease
PMOID: PMO:00033626
Subclass_of: intestinal disease
Synonym: DIARRHEA, TROPICAL
Synonym: Idiopathic Tropical Malabsorption Syndrome
Synonym: Post-Infective Tropical Malabsorption
Synonym: SPRUE, TROPICAL
Synonym: Sprue - tropical
Synonym: Sprue, Tropical
Synonym: Sprue, Tropical [Disease/Finding]
Synonym: TS - Tropical sprue
Synonym: Tropical Sprue
Synonym: Tropical enteropathy
Tree Number: T10.8.11.8.27
database_cross_reference: CHV:0000011670
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1248-6856
database_cross_reference: DO:DOID:10607
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001780
database_cross_reference: ICD10:K90.1
database_cross_reference: ICD10AM:K90.1
database_cross_reference: ICD10CM:K90.1
database_cross_reference: ICD9CM:579.1
database_cross_reference: LCH_NW:sh85138063
database_cross_reference: MDR:10044697
database_cross_reference: MEDCIN:30291
database_cross_reference: MSH:D013182
database_cross_reference: MTHICD9:579.1
database_cross_reference: NCI:C45428
database_cross_reference: NDFRT:N0000002815
database_cross_reference: RCD:J691.
database_cross_reference: SNM:D-6221
database_cross_reference: SNMI:D5-47150
database_cross_reference: SNOMEDCT_US:155846005
database_cross_reference: SNOMEDCT_US:266547002
database_cross_reference: SNOMEDCT_US:47384003

pancreatic steatorrhea
type: Class
subclass of: pancreas disease
PMOID: PMO:00033195
Subclass_of: pancreas disease
Synonym: Pancreatic steatorrhea
Synonym: Pancreatic steatorrhea (disorder)
Synonym: Pancreatic steatorrhea [dup] (disorder)
Synonym: Pancreatic steatorrhea syndrome
Synonym: Pancreatic steatorrhoea
Synonym: Pancreatic steatorrhoea (disorder)
Synonym: pancreatic steatorrhea (diagnosis)
Synonym: pancreatic steatorrhoea
Tree Number: T10.8.8.4.1
database_cross_reference: DO:DOID:10610
database_cross_reference: ICD10:K90.3
database_cross_reference: ICD10AM:K90.3
database_cross_reference: ICD10AMAE:K90.3
database_cross_reference: ICD10CM:K90.3
database_cross_reference: ICD9CM:579.4
database_cross_reference: MDR:10033641
database_cross_reference: MDR:10033642
database_cross_reference: MEDCIN:35582
database_cross_reference: RCD:J694.
database_cross_reference: RCDAE:J694.
database_cross_reference: SNM:D-6393
database_cross_reference: SNM:F-61860
database_cross_reference: SNMI:D5-90480
database_cross_reference: SNOMEDCT_US:155845009
database_cross_reference: SNOMEDCT_US:197487009
database_cross_reference: SNOMEDCT_US:54576000

protein-losing enteropathy
type: Class
subclass of: intestinal disease
PMOID: PMO:00033620
Subclass_of: intestinal disease
Synonym: ENTEROPATHY, PROTEIN-LOSING
Synonym: Enteropathies, Exudative
Synonym: Enteropathies, Protein-Losing
Synonym: Enteropathy, Exudative
Synonym: Enteropathy, Protein-Losing
Synonym: Enteropathy, exudative
Synonym: Enteropathy, protein-losing
Synonym: Exudative Enteropathies
Synonym: Exudative Enteropathy
Synonym: Exudative enteropathy
Tree Number: T10.8.11.8.22
database_cross_reference: AOD:0000005579
database_cross_reference: AOD:0000005583
database_cross_reference: CHV:0000010248
database_cross_reference: DO:DOID:10611
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000566
database_cross_reference: HPO:HP:0002243
database_cross_reference: LCH:U003879
database_cross_reference: LCH_NW:sh85107661
database_cross_reference: MEDCIN:30214
database_cross_reference: MSH:D011504
database_cross_reference: MTH:U002197
database_cross_reference: MTHICD9:579.8
database_cross_reference: NDFRT:N0000002505
database_cross_reference: OMIM:226300
database_cross_reference: OMIM:MTHU005035
database_cross_reference: RCD:J69y1
database_cross_reference: SNM:D-6224
database_cross_reference: SNMI:D5-47160
database_cross_reference: SNMI:D5-47170
database_cross_reference: SNOMEDCT_US:22542007
database_cross_reference: SNOMEDCT_US:66972006

Wolfram syndrome
type: Class
subclass of: syndrome
definition: An autosomal recessive disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the WFS1 gene on chromosome 4p16.1.
PMOID: PMO:00025229
Subclass_of: syndrome
Synonym: DIABETES INSIPIDUS AND MELLITUS WITH OPTIC ATROPHY AND DEAFNESS
Synonym: DIDMOAD
Synonym: DIDMOAD - Diabetes insipidus, diabetes mellitus, optic atrophy and deafness
Synonym: DIDMOAD - Diabetes insipidus,diabetes mellitus, optic atrophy and deafness
Synonym: DIDMOAD Syndrome
Synonym: DIDMOAD syndrome
Synonym: DIDMOAD-Diab insip,diab mel,optic atroph+deafness
Synonym: DIDMOADUD
Synonym: Diab ins,diab mell,opt at,deaf
Synonym: Diab insipidus,diab mell,optic atrophy and deafness
Tree Number: T10.1.93
database_cross_reference: CHV:0000013178
database_cross_reference: CSP:0977-5687
database_cross_reference: CSP:2042-6601
database_cross_reference: DO:DOID:0110629
database_cross_reference: DO:DOID:10632
database_cross_reference: JABL:660
database_cross_reference: MDR:10078338
database_cross_reference: MDR:10078339
database_cross_reference: MEDCIN:354152
database_cross_reference: MSH:D014929
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35133
database_cross_reference: NDFRT:N0000003167
database_cross_reference: OMIM:222300
database_cross_reference: OMIM:606201
database_cross_reference: RCD:X008t
database_cross_reference: SNM:D-X435
database_cross_reference: SNMI:DB-61790
database_cross_reference: SNOMEDCT_US:70694009

cystinosis
type: Class
subclass of: lysosomal storage disease
definition: A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and has material basis in mutations in the CTNS gene, located on chromosome 17.
PMOID: PMO:00029114
Subclass_of: lysosomal storage disease
Synonym: 6-B5 CYSTINOSIS
Synonym: CTNS
Synonym: CYSTINOSIN, DEFECT OF
Synonym: CYSTINOSIS
Synonym: CYSTINOSIS, NEPHROPATHIC
Synonym: Cystine Diatheses
Synonym: Cystine Diathesis
Synonym: Cystine Disease
Synonym: Cystine Diseases
Synonym: Cystine Storage Disease
Tree Number: T10.6.2.8.11
database_cross_reference: AOD:0000005736
database_cross_reference: CHV:0000003556
database_cross_reference: CSP:1849-0607
database_cross_reference: DO:DOID:1064
database_cross_reference: DXP:U000431
database_cross_reference: ICD10CM:E72.04
database_cross_reference: LCH:U001244
database_cross_reference: LCH_NW:sh85035212
database_cross_reference: MDR:10011777
database_cross_reference: MDR:10071112
database_cross_reference: MEDCIN:33538
database_cross_reference: MSH:D003554
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:270.0
database_cross_reference: NCI:C2976
database_cross_reference: NDFRT:N0000000892
database_cross_reference: OMIM:219800
database_cross_reference: OMIM:606272
database_cross_reference: RCD:C3000
database_cross_reference: SNM:D-1731
database_cross_reference: SNMI:D6-B5000
database_cross_reference: SNMI:D6-B5300
database_cross_reference: SNOMEDCT_US:111398009
database_cross_reference: SNOMEDCT_US:190681003
database_cross_reference: SNOMEDCT_US:190683000
database_cross_reference: SNOMEDCT_US:367374009
database_cross_reference: SNOMEDCT_US:62332007

schizotypal personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs.
PMOID: PMO:00027907
Subclass_of: personality disorder
Synonym: Disorder, Schizotypal Personality
Synonym: Disorders, Schizotypal Personality
Synonym: PERSONALITY DIS SCHIZOTYPAL
Synonym: Personality Disorder, Schizotypal
Synonym: Personality Disorders, Schizotypal
Synonym: SCHIZOTYPAL PERSONALITY DIS
Synonym: Schizoptypal disorder
Synonym: Schizotypal Personality Disorder
Synonym: Schizotypal Personality Disorder [Disease/Finding]
Synonym: Schizotypal Personality Disorders
Tree Number: T10.3.2.9
database_cross_reference: AOD:0000006653
database_cross_reference: CHV:0000011092
database_cross_reference: CSP:2483-7296
database_cross_reference: DO:DOID:10646
database_cross_reference: DSM-5:301.22
database_cross_reference: DSM-5:F21
database_cross_reference: ICD10CM:F21
database_cross_reference: ICD9CM:301.22
database_cross_reference: LCH_NW:sh85108286
database_cross_reference: MDR:10039650
database_cross_reference: MDR:10039651
database_cross_reference: MEDCIN:32849
database_cross_reference: MSH:D012569
database_cross_reference: NCI:C92632
database_cross_reference: NDFRT:N0000002695
database_cross_reference: PSY:45465
database_cross_reference: RCD:E2122
database_cross_reference: SNMI:D9-61300
database_cross_reference: SNOMEDCT_US:231486008
database_cross_reference: SNOMEDCT_US:31027006

separation anxiety disorder
type: Class
subclass of: anxiety disorder
PMOID: PMO:00028222
Subclass_of: anxiety disorder
Synonym: Anxiety Disorder, Separation
Synonym: Anxiety, Separation
Synonym: Anxiety, Separation [Disease/Finding]
Synonym: SEPARATION ANXIETY DIS
Synonym: Separation Anxiety
Synonym: Separation Anxiety Disorder
Synonym: Separation anxiety
Synonym: Separation anxiety (disorder)
Synonym: Separation anxiety disorder
Synonym: anxiety disorder separation
Tree Number: T10.3.12.5.3
database_cross_reference: AOD:0000006846
database_cross_reference: CHV:0000001345
database_cross_reference: DSM-5:309.21
database_cross_reference: DSM-5:F93.0
database_cross_reference: ICD9CM:309.21
database_cross_reference: MDR:10040045
database_cross_reference: MEDCIN:350204
database_cross_reference: MSH:D001010
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35014
database_cross_reference: NCI_NICHD:C35014
database_cross_reference: NDFRT:N0000000436
database_cross_reference: SNOMEDCT_US:11806006
database_cross_reference: SNOMEDCT_US:126943008

hypertrophy of breast
type: Class
subclass of: breast disease
definition: A breast disease that is characterized by the progressive, excessive enlargement of breast connective tissue.
PMOID: PMO:00033256
Subclass_of: breast disease
Synonym: Breast Hypertrophy
Synonym: Breast hypertrophy
Synonym: Hypertrophy - breast
Synonym: Hypertrophy breast
Synonym: Hypertrophy of Breast
Synonym: Hypertrophy of breast
Synonym: Hypertrophy of breast (disorder)
Synonym: Hypertrophy of breast NOS
Synonym: Hypertrophy of breast NOS (disorder)
Synonym: Hypertrophy of breast, NOS
Tree Number: T10.8.9.1.5
database_cross_reference: CHV:0000006457
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10688
database_cross_reference: HPO:HP:0010313
database_cross_reference: ICD10:N62
database_cross_reference: ICD10AM:N62
database_cross_reference: ICD10CM:N62
database_cross_reference: ICD9CM:611.1
database_cross_reference: MDR:10020881
database_cross_reference: MDR:10020885
database_cross_reference: MDR:10026733
database_cross_reference: MEDCIN:7100
database_cross_reference: MEDCIN:91891
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:611.1
database_cross_reference: NCI:C3125
database_cross_reference: RCD:K311.
database_cross_reference: RCD:K311z
database_cross_reference: SNMI:D7-90400
database_cross_reference: SNOMEDCT_US:155963008
database_cross_reference: SNOMEDCT_US:198114003
database_cross_reference: SNOMEDCT_US:266646002
database_cross_reference: SNOMEDCT_US:372281005
database_cross_reference: SNOMEDCT_US:43336006

mastitis
type: Class
subclass of: breast disease
definition: A breast disease characterized by painful infection of the breast tissue.
PMOID: PMO:00033254
Subclass_of: breast disease
Synonym: BREAST INFLAMMATION
Synonym: Breast infection
Synonym: Breast inflammation
Synonym: Breast inflammation NOS
Synonym: Breast inflammation NOS (disorder)
Synonym: Inflammatory breast disease
Synonym: Inflammatory disease of breast
Synonym: MASTITIS
Synonym: Mammitis
Synonym: Mastitis
Tree Number: T10.8.9.1.4
database_cross_reference: CCPSS:0046699
database_cross_reference: CHV:0000007787
database_cross_reference: COSTAR:U000436
database_cross_reference: CSP:2587-5865
database_cross_reference: CST:MASTITIS
database_cross_reference: DO:DOID:10690
database_cross_reference: LCH:U002833
database_cross_reference: LCH_NW:sh85082006
database_cross_reference: MDR:10006262
database_cross_reference: MDR:10026883
database_cross_reference: MDR:10073963
database_cross_reference: MEDCIN:33095
database_cross_reference: MSH:D008413
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:611.0
database_cross_reference: NCI:C53662
database_cross_reference: NCI_CTCAE:E11318
database_cross_reference: NCI_NCI-GLOSS:CDR0000638194
database_cross_reference: NCI_NICHD:C53662
database_cross_reference: NDFRT:N0000001947
database_cross_reference: RCD:X40FT
database_cross_reference: RCD:XE0g1
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D7-90100
database_cross_reference: SNOMEDCT_US:155952005
database_cross_reference: SNOMEDCT_US:155955007
database_cross_reference: SNOMEDCT_US:198099006
database_cross_reference: SNOMEDCT_US:266641007
database_cross_reference: SNOMEDCT_US:266644004
database_cross_reference: SNOMEDCT_US:45198002

fat necrosis of breast
type: Class
subclass of: breast disease
definition: A breast disease that is characterized by the death of breast adipocytes, usually secondary to injury.
PMOID: PMO:00033257
Subclass_of: breast disease
Synonym: BREAST, FAT NECROSIS
Synonym: Breast Fat Necrosis
Synonym: Fat Necrosis of Breast
Synonym: Fat Necrosis of the Breast
Synonym: Fat necrosis of breast
Synonym: Fat necrosis of breast (disorder)
Synonym: breast Fat necrosis
Synonym: breast fat necrosis
Synonym: breasts fat necrosis
Synonym: fat necrosis breast
Tree Number: T10.8.9.1.6
database_cross_reference: CHV:0000017569
database_cross_reference: DO:DOID:10691
database_cross_reference: DXP:U000246
database_cross_reference: ICD10:N64.1
database_cross_reference: ICD10AM:N64.1
database_cross_reference: ICD10CM:N64.1
database_cross_reference: ICD9CM:611.3
database_cross_reference: MDR:10016249
database_cross_reference: MEDCIN:33094
database_cross_reference: NCI:C3661
database_cross_reference: RCD:K313.
database_cross_reference: SNMI:D7-90434
database_cross_reference: SNOMEDCT_US:21381006

paragonimiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection by flukes of the genus Paragonimus. In the acute phase, the symptoms are diarrhea, abdominal pain, fever, cough, urticaria, hepatosplenomegaly, pulmonary abnormalities, and eosinophilia. Pulmonary manifestations include cough, expectoration of discolored sputum, hemoptysis, and chest radiographic abnormalities. Various organs like brain, spleen and liver can be infected.
PMOID: PMO:00029623
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Paragonimus
Synonym: lung fluke disease
Synonym: lung fluke infection
Synonym: pulmonary paragonimiasis
Tree Number: T10.7.4.1.6
database_cross_reference: DO:DOID:10699

giardiasis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.
PMOID: PMO:00029703
Subclass_of: parasitic protozoa infectious disease
Synonym: Infection by Giardia lamblia
Synonym: beaver feaver
Tree Number: T10.7.4.2.12
database_cross_reference: DO:DOID:10718

kidney failure
type: Class
subclass of: kidney disease
definition: A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood.
PMOID: PMO:00033029
Subclass_of: kidney disease
Synonym: ESRD
Synonym: FAILURE KIDNEY
Synonym: Failure kidney
Synonym: Failure, Kidney
Synonym: Failure, Renal
Synonym: Failure;renal;NOS
Synonym: Failures, Kidney
Synonym: Failures, Renal
Synonym: KIDNEY FAILURE
Synonym: Kidney Failure
Tree Number: T10.8.7.9.12
database_cross_reference: AOD:0000005855
database_cross_reference: AOD:0000023509
database_cross_reference: CCPSS:0034797
database_cross_reference: CHV:0000010720
database_cross_reference: COSTAR:647
database_cross_reference: CSP:1682-2744
database_cross_reference: CST:KIDNEY FAIL
database_cross_reference: DO:DOID:1074
database_cross_reference: DXP:U003357
database_cross_reference: HPO:HP:0000083
database_cross_reference: ICD10:N17-N19.9
database_cross_reference: ICD10:N19
database_cross_reference: ICD10AM:N17-N19.9
database_cross_reference: ICD10AM:N19
database_cross_reference: ICD10CM:N19
database_cross_reference: ICD9CM:586
database_cross_reference: ICPC2P:U99030
database_cross_reference: LNC:MTHU020824
database_cross_reference: MDR:10016149
database_cross_reference: MDR:10023418
database_cross_reference: MDR:10038435
database_cross_reference: MDR:10038448
database_cross_reference: MDR:10038449
database_cross_reference: MDR:10038450
database_cross_reference: MEDCIN:36096
database_cross_reference: MEDLINEPLUS:302
database_cross_reference: MSH:D051437
database_cross_reference: MTH:647
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4376
database_cross_reference: NCI_FDA:2041
database_cross_reference: NCI_NCI-GLOSS:CDR0000440109
database_cross_reference: NCI_NCI-GLOSS:CDR0000462925
database_cross_reference: NCI_NICHD:C4376
database_cross_reference: NDFRT:N0000003529
database_cross_reference: OMIM:MTHU000623
database_cross_reference: PDQ:CDR0000529777
database_cross_reference: RCD:X30Io
database_cross_reference: RCD:XE0dg
database_cross_reference: SNM:D-6510
database_cross_reference: SNMI:D7-11010
database_cross_reference: SNOMEDCT_US:156092003
database_cross_reference: SNOMEDCT_US:197656003
database_cross_reference: SNOMEDCT_US:198524000
database_cross_reference: SNOMEDCT_US:266553002
database_cross_reference: SNOMEDCT_US:266616000
database_cross_reference: SNOMEDCT_US:42399005
database_cross_reference: SNOMEDCT_US:723188008
database_cross_reference: SNOMEDCT_VET:42399005

filariasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea.
PMOID: PMO:00029650
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Elaeophoriases
Synonym: Elaeophoriasis
Synonym: disease due to superfamily Filarioidea
Tree Number: T10.7.4.1.28
database_cross_reference: DO:DOID:1080
database_cross_reference: MSH:D005368

gastric ulcer
type: Class
subclass of: peptic ulcer disease
PMOID: PMO:00033434
Subclass_of: peptic ulcer disease
Synonym: GASTRIC ULCER
Synonym: GASTRIC ULCER DISEASE
Synonym: GASTRIC ULCERATION
Synonym: GU
Synonym: GU - Gastric ulcer
Synonym: Gastric Ulcer
Synonym: Gastric Ulcers
Synonym: Gastric ulcer
Synonym: Gastric ulcer (disorder)
Synonym: Gastric ulcer - (GU)
Tree Number: T10.8.11.1.4
database_cross_reference: AOD:0000005590
database_cross_reference: AOD:0000023378
database_cross_reference: BI:BI00248
database_cross_reference: CCPSS:0030239
database_cross_reference: CCPSS:0056079
database_cross_reference: CHV:0000011744
database_cross_reference: COSTAR:321
database_cross_reference: COSTAR:U000312
database_cross_reference: CSP:1248-6649
database_cross_reference: CST:ULCER STOMACH
database_cross_reference: DO:DOID:10808
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000698
database_cross_reference: DXP:U001645
database_cross_reference: HPO:HP:0002592
database_cross_reference: ICD10:K25
database_cross_reference: ICD10AM:K25
database_cross_reference: ICD10CM:K25
database_cross_reference: ICD9CM:531
database_cross_reference: ICPC2P:D86004
database_cross_reference: ICPC2P:D86008
database_cross_reference: LCH_NW:sh85128275
database_cross_reference: MDR:10017822
database_cross_reference: MDR:10018765
database_cross_reference: MDR:10042116
database_cross_reference: MDR:10045304
database_cross_reference: MDR:10045336
database_cross_reference: MDR:10045374
database_cross_reference: MEDCIN:30227
database_cross_reference: MEDLINEPLUS:357
database_cross_reference: MSH:D013276
database_cross_reference: MTH:321
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3388
database_cross_reference: NCI_CTCAE:E10727
database_cross_reference: NDFRT:N0000002830
database_cross_reference: OMIM:MTHU036758
database_cross_reference: RCD:J11y.
database_cross_reference: RCD:J11yz
database_cross_reference: RCD:XE0aP
database_cross_reference: RCD:XE0aQ
database_cross_reference: SNM:M-38000
database_cross_reference: SNMI:D5-32100
database_cross_reference: SNOMEDCT_US:155681009
database_cross_reference: SNOMEDCT_US:155690002
database_cross_reference: SNOMEDCT_US:196627009
database_cross_reference: SNOMEDCT_US:196642007
database_cross_reference: SNOMEDCT_US:196649003
database_cross_reference: SNOMEDCT_US:196650003
database_cross_reference: SNOMEDCT_US:266436006
database_cross_reference: SNOMEDCT_US:397825006
database_cross_reference: SNOMEDCT_US:6034002

sexual sadism
type: Class
subclass of: sexual disorder
PMOID: PMO:00028157
Subclass_of: sexual disorder
Synonym: Sadism, Sexual
Synonym: Sadisms, Sexual
Synonym: Sexual Sadism
Synonym: Sexual Sadisms
Synonym: Sexual sadism
Synonym: Sexual sadism (disorder)
Synonym: Sexual sadism disorder
Synonym: sexual sadism disorder
Synonym: sexual sadism disorder (diagnosis)
Tree Number: T10.3.11.3
database_cross_reference: AOD:0000006810
database_cross_reference: CHV:0000011283
database_cross_reference: DO:DOID:10817
database_cross_reference: DSM-5:302.84
database_cross_reference: DSM-5:F65.52
database_cross_reference: ICD10CM:F65.52
database_cross_reference: ICD9CM:302.84
database_cross_reference: MDR:10040487
database_cross_reference: MEDCIN:32819
database_cross_reference: MSH:D012448
database_cross_reference: NCI:C94358
database_cross_reference: PSY:47100
database_cross_reference: RCD:E22y3
database_cross_reference: SNM:F-99500
database_cross_reference: SNMI:D9-73230
database_cross_reference: SNOMEDCT_US:59394009

voyeurism
type: Class
subclass of: paraphilia disorder
PMOID: PMO:00028155
Subclass_of: paraphilia disorder
Synonym: Voyeurism
Synonym: Voyeurism (disorder)
Synonym: Voyeurism [Disease/Finding]
Synonym: Voyeurisms
Synonym: voyeurism (diagnosis)
Tree Number: T10.3.11.2.4
database_cross_reference: AOD:0000006806
database_cross_reference: CHV:0000013090
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10834
database_cross_reference: ICD10:F65.3
database_cross_reference: ICD10AM:F65.3
database_cross_reference: ICD10CM:F65.3
database_cross_reference: ICD9CM:302.82
database_cross_reference: LCH_NW:sh85118773
database_cross_reference: MDR:10047717
database_cross_reference: MEDCIN:32817
database_cross_reference: MSH:D014843
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94360
database_cross_reference: NDFRT:N0000003144
database_cross_reference: PSY:56370
database_cross_reference: RCD:E22y1
database_cross_reference: SNM:F-99630
database_cross_reference: SNMI:D9-73250
database_cross_reference: SNOMEDCT_US:192515002
database_cross_reference: SNOMEDCT_US:63835008

chylocele of tunica vaginalis
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029777
Subclass_of: male reproductive system disease
Synonym: Chylocele of tunica vaginalis
Synonym: Chylocele of tunica vaginalis (disorder)
Synonym: Chylocele, tunic vaginal
Synonym: Chylocoele of tunica vaginalis
Synonym: chylocele of tunica vaginalis (diagnosis)
Tree Number: T10.8.1.3.13
database_cross_reference: DO:DOID:10835
database_cross_reference: ICD9CM:608.84
database_cross_reference: MDR:10009166
database_cross_reference: MEDCIN:96740
database_cross_reference: RCD:K287.
database_cross_reference: SNMI:D7-54120
database_cross_reference: SNOMEDCT_US:7864001

Eastern equine encephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Eastern equine encephalitis virus, which is transmitted by Aedes, transmitted by Coquillettidia, and transmitted by Culex species of mosquitoes. The infection has symptom sudden onset of headache, has symptom high fever, has symptom chills, has symptom vomiting, has symptom disorientation, has symptom seizures, and has symptom coma.
PMOID: PMO:00029456
Subclass_of: viral infectious disease
Synonym: EASTERN EQUINE ENCEPH
Synonym: EASTERN EQUINE ENCEPHALOMYELITIS
Synonym: EEE
Synonym: EEE - Eastern equine encephal
Synonym: EEE - Eastern equine encephalitis
Synonym: EEE infection
Synonym: ENCEPH EASTERN EQUINE
Synonym: ENCEPHALITIS, EASTERN EQUINE
Synonym: East equine encephalitis
Synonym: Eastern Equine Encephalitides
Tree Number: T10.7.2.85
database_cross_reference: CHV:0000017316
database_cross_reference: DO:DOID:10841
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000532
database_cross_reference: ICD10:A83.2
database_cross_reference: ICD10AM:A83.2
database_cross_reference: ICD10CM:A83.2
database_cross_reference: ICD9CM:062.2
database_cross_reference: LNC:LA20113-9
database_cross_reference: MDR:10014060
database_cross_reference: MDR:10014061
database_cross_reference: MDR:10014274
database_cross_reference: MDR:10014587
database_cross_reference: MEDCIN:30856
database_cross_reference: MSH:D020242
database_cross_reference: NDFRT:N0000004071
database_cross_reference: RCD:A622.
database_cross_reference: SNM:D-0390
database_cross_reference: SNMI:DE-33120
database_cross_reference: SNOMEDCT_US:40177004
database_cross_reference: SNOMEDCT_US:416925005
database_cross_reference: SNOMEDCT_US:417496004

Murray Valley encephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.
PMOID: PMO:00029364
Subclass_of: viral infectious disease
Synonym: Australian X disease
Synonym: Australian arboencephalitis
Synonym: Australian encephalitis
Synonym: Australian encephalitis (diagnosis)
Synonym: Encephalitis australia
Synonym: MVE
Synonym: MVE - Murray Valley encephalit
Synonym: MVE - Murray Valley encephalitis
Synonym: Murray River encephalitis
Synonym: Murray Valley encephalitis (diagnosis)
Tree Number: T10.7.2.17
database_cross_reference: CHV:0000017317
database_cross_reference: DO:DOID:10842
database_cross_reference: ICD10:A83.4
database_cross_reference: ICD10AM:A83.4
database_cross_reference: ICD10CM:A83.4
database_cross_reference: ICD9CM:062.4
database_cross_reference: MDR:10003804
database_cross_reference: MDR:10014583
database_cross_reference: MDR:10053981
database_cross_reference: MEDCIN:212986
database_cross_reference: MEDCIN:97444
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:062.4
database_cross_reference: RCD:A624.
database_cross_reference: SNM:D-0434
database_cross_reference: SNMI:DE-33290
database_cross_reference: SNOMEDCT_US:66454007

Western equine encephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.
PMOID: PMO:00029435
Subclass_of: viral infectious disease
Synonym: ENCEPH WESTERN EQUINE
Synonym: ENCEPHALITIS, WESTERN EQUINE
Synonym: Encephalitis western equine
Synonym: Encephalitis, Western Equine
Synonym: Encephalitis, Western equine
Synonym: Encephalomyelitis, Western Equine
Synonym: Encephalomyelitis, Western Equine [Disease/Finding]
Synonym: Equine Encephalitis, Western
Synonym: Equine encephalitis, Western (WEE)
Synonym: WEE
Tree Number: T10.7.2.67
database_cross_reference: CHV:0000017315
database_cross_reference: CSP:2042-4972
database_cross_reference: DO:DOID:10843
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000538
database_cross_reference: ICD10:A83.1
database_cross_reference: ICD10AM:A83.1
database_cross_reference: ICD10CM:A83.1
database_cross_reference: ICD9CM:062.1
database_cross_reference: LNC:LA20112-1
database_cross_reference: MDR:10014614
database_cross_reference: MDR:10047885
database_cross_reference: MDR:10047915
database_cross_reference: MDR:10047916
database_cross_reference: MEDCIN:30860
database_cross_reference: MSH:D020241
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85227
database_cross_reference: NDFRT:N0000004070
database_cross_reference: RCD:A621.
database_cross_reference: SNM:D-0392
database_cross_reference: SNMI:DE-33130
database_cross_reference: SNOMEDCT_US:47523006

Japanese encephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis.
PMOID: PMO:00029360
Subclass_of: viral infectious disease
Synonym: ENCEPH JAPANESE
Synonym: ENCEPH JAPANESE B
Synonym: ENCEPHALITIS, JAPANESE B
Synonym: ENCEPHALITIS, RUSSIAN AUTUMNAL
Synonym: ENCEPHALITIS, SUMMER
Synonym: Encephalitis Japanese B
Synonym: Encephalitis, Japanese
Synonym: Encephalitis, Japanese B
Synonym: Encephalitis, Japanese [Disease/Finding]
Synonym: JAPANESE B ENCEPH
Tree Number: T10.7.2.13
database_cross_reference: CHV:0000004418
database_cross_reference: DO:DOID:10844
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000535
database_cross_reference: ICD10:A83.0
database_cross_reference: ICD10AM:A83.0
database_cross_reference: ICD10CM:A83.0
database_cross_reference: ICD9CM:062.0
database_cross_reference: LCH:U005514
database_cross_reference: LCH_NW:sh85069621
database_cross_reference: MDR:10014596
database_cross_reference: MDR:10023119
database_cross_reference: MDR:10023120
database_cross_reference: MDR:10023123
database_cross_reference: MEDCIN:30857
database_cross_reference: MSH:D004672
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:062.0
database_cross_reference: NCI:C34577
database_cross_reference: NDFRT:N0000001079
database_cross_reference: RCD:A620.
database_cross_reference: SNM:D-0415
database_cross_reference: SNMI:DE-33300
database_cross_reference: SNOMEDCT_US:154345006
database_cross_reference: SNOMEDCT_US:266194002
database_cross_reference: SNOMEDCT_US:52947006

St. Louis encephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.
PMOID: PMO:00029356
Subclass_of: viral infectious disease
Synonym: ENCEPH SAINT LOUIS
Synonym: ENCEPH ST LOUIS
Synonym: ENCEPH VIRAL ST LOUIS
Synonym: ENCEPHALITIS C
Synonym: ENCEPHALITIS, SAINT LOUIS
Synonym: Encephalitis, Saint Louis
Synonym: Encephalitis, St-Louis
Synonym: Encephalitis, St. Louis
Synonym: Encephalitis, St. Louis [Disease/Finding]
Synonym: Encephalitis, Viral, St. Louis
Tree Number: T10.7.2.9
database_cross_reference: CHV:0000004420
database_cross_reference: CSP:2042-4896
database_cross_reference: DO:DOID:10845
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000537
database_cross_reference: ICD10:A83.3
database_cross_reference: ICD10AM:A83.3
database_cross_reference: ICD10CM:A83.3
database_cross_reference: ICD9CM:062.3
database_cross_reference: LCH:U004454
database_cross_reference: LCH_NW:sh85127171
database_cross_reference: MDR:10041896
database_cross_reference: MDR:10041898
database_cross_reference: MEDCIN:30858
database_cross_reference: MSH:D004674
database_cross_reference: MTH:U001886
database_cross_reference: NDFRT:N0000001081
database_cross_reference: RCD:A623.
database_cross_reference: SNM:D-0472
database_cross_reference: SNMI:DE-33280
database_cross_reference: SNOMEDCT_US:10429004
database_cross_reference: SNOMEDCT_US:417192005
database_cross_reference: SNOMEDCT_US:417607009

angiodysplasia of intestine
type: Class
subclass of: intestinal disease
PMOID: PMO:00033528
Subclass_of: intestinal disease
Synonym: Angio intes w/o hmrhg
Synonym: Angiodysplasia of intestinal tract
Synonym: Angiodysplasia of intestinal tract (disorder)
Synonym: Angiodysplasia of intestinal tract, NOS
Synonym: Angiodysplasia of intestine
Synonym: Angiodysplasia of intestine (disorder)
Synonym: Angiodysplasia of intestine (without mention of haemorrhage)
Synonym: Angiodysplasia of intestine (without mention of hemorrhage)
Synonym: Angiodysplasia of intestine without mention of hemorrhage
Synonym: Intestinal vascular dysplasia
Tree Number: T10.8.11.8.2
database_cross_reference: CHV:0000026151
database_cross_reference: DO:DOID:10846
database_cross_reference: ICD9CM:569.84
database_cross_reference: MDR:10002420
database_cross_reference: MDR:10055758
database_cross_reference: MTHICD9:569.84
database_cross_reference: RCD:X306J
database_cross_reference: SNMI:D5-40200
database_cross_reference: SNOMEDCT_US:235853006
database_cross_reference: SNOMEDCT_US:32868004

sexual masochism
type: Class
subclass of: sexual disorder
PMOID: PMO:00028163
Subclass_of: sexual disorder
Synonym: Masochism, Sexual
Synonym: Masochisms, Sexual
Synonym: Sexual Masochism
Synonym: Sexual Masochisms
Synonym: Sexual masochism
Synonym: Sexual masochism (disorder)
Synonym: Sexual masochism (finding)
Synonym: Sexual masochism disorder
Synonym: sexual masochism disorder
Synonym: sexual masochism disorder (diagnosis)
Tree Number: T10.3.11.5
database_cross_reference: AOD:0000006808
database_cross_reference: CHV:0000011281
database_cross_reference: DO:DOID:10849
database_cross_reference: DSM-5:302.83
database_cross_reference: DSM-5:F65.51
database_cross_reference: ICD10CM:F65.51
database_cross_reference: ICD9CM:302.83
database_cross_reference: MDR:10040484
database_cross_reference: MEDCIN:32818
database_cross_reference: MSH:D008398
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94356
database_cross_reference: PSY:47070
database_cross_reference: RCD:E22y2
database_cross_reference: SNM:F-99400
database_cross_reference: SNMI:D9-73220
database_cross_reference: SNOMEDCT_US:248104007
database_cross_reference: SNOMEDCT_US:51239001

Edwards syndrome
type: Class
subclass of: chromosomal disease
PMOID: PMO:00028759
Subclass_of: chromosomal disease
Synonym: 18 trisomy
Synonym: Chromosomal imbalance syndrome, pair 18, trisomy
Synonym: Chromosome 18 trisomy
Synonym: Complete Trisomy 18 Syndrome
Synonym: Complete trisomy 18 syndrome
Synonym: Complete trisomy 18 syndrome (disorder)
Synonym: E3 Trisomy
Synonym: EDWARDS SYNDROME
Synonym: Edward's syndrome
Synonym: Edward's syndrome NOS
Tree Number: T10.5.9.4
database_cross_reference: CHV:0000017166
database_cross_reference: DO:DOID:1085
database_cross_reference: ICD10:Q91.3
database_cross_reference: ICD10AM:Q91.3
database_cross_reference: ICD10CM:Q91.3
database_cross_reference: ICD9CM:758.2
database_cross_reference: JABL:191
database_cross_reference: LNC:LP187146-8
database_cross_reference: LNC:LP70387-3
database_cross_reference: LNC:MTHU048467
database_cross_reference: MDR:10014272
database_cross_reference: MDR:10014273
database_cross_reference: MDR:10053884
database_cross_reference: MEDCIN:30420
database_cross_reference: MSH:C580500
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:758.2
database_cross_reference: NCI:C101362
database_cross_reference: NCI_NICHD:C101362
database_cross_reference: OMIM:300484
database_cross_reference: RCD:PJ2..
database_cross_reference: RCD:X78Em
database_cross_reference: SNM:D-5682
database_cross_reference: SNMI:D4-02184
database_cross_reference: SNOMEDCT_US:157022000
database_cross_reference: SNOMEDCT_US:205626006
database_cross_reference: SNOMEDCT_US:254265001
database_cross_reference: SNOMEDCT_US:51500006

salivary gland disease
type: Class
subclass of: mouth disease
PMOID: PMO:00033723
Subclass_of: mouth disease
Synonym: 5-20 DISEASES OF THE SALIVARY GLANDS
Synonym: DISEASES OF THE SALIVARY GLANDS
Synonym: Disease of salivary gland
Synonym: Disease of salivary gland (disorder)
Synonym: Disease of salivary gland, NOS
Synonym: Disease of salivary gland, unspecified
Synonym: Disease of salivary glands
Synonym: Disease, Salivary Gland
Synonym: Diseases of salivary glands
Synonym: Diseases of the salivary glands
Tree Number: T10.8.11.11.8
database_cross_reference: CCPSS:0037756
database_cross_reference: CHV:0000011008
database_cross_reference: CSP:2139-2285
database_cross_reference: CST:DIG/SAL
database_cross_reference: HPO:HP:0010286
database_cross_reference: ICD10:K11
database_cross_reference: ICD10:K11.9
database_cross_reference: ICD10AM:K11
database_cross_reference: ICD10AM:K11.9
database_cross_reference: ICD10CM:K11
database_cross_reference: ICD10CM:K11.9
database_cross_reference: ICD9CM:527
database_cross_reference: ICD9CM:527.9
database_cross_reference: LCH_NW:sh85116808
database_cross_reference: MDR:10013136
database_cross_reference: MDR:10039405
database_cross_reference: MDR:10045759
database_cross_reference: MDR:10061935
database_cross_reference: MEDCIN:210394
database_cross_reference: MEDLINEPLUS:388
database_cross_reference: MSH:D012466
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26879
database_cross_reference: NDFRT:N0000002662
database_cross_reference: RCD:J07..
database_cross_reference: RCD:J07z.
database_cross_reference: SNM:D-6120
database_cross_reference: SNMI:D5-20000
database_cross_reference: SNOMEDCT_US:10890000
database_cross_reference: SNOMEDCT_US:155654009
database_cross_reference: SNOMEDCT_US:155658007
database_cross_reference: SNOMEDCT_US:196526006

meningocele
type: Class
subclass of: spina bifida
PMOID: PMO:00028274
Subclass_of: spina bifida
Synonym: Herniation of Meninges
Synonym: Herniation, Meningeal
Synonym: Herniations, Meningeal
Synonym: Meningeal Herniation
Synonym: Meningeal Herniations
Synonym: Meninges Herniation
Synonym: Meninges Herniations
Synonym: Meningocele
Synonym: Meningocele (disorder)
Synonym: Meningocele [Ambiguous]
Tree Number: T10.4.16.2.2
database_cross_reference: CHV:0000007939
database_cross_reference: DO:DOID:1088
database_cross_reference: HPO:HP:0002435
database_cross_reference: MSH:D008588
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001988
database_cross_reference: SNOMEDCT_US:156890007
database_cross_reference: SNOMEDCT_US:171131006
database_cross_reference: SNOMEDCT_US:253121009
database_cross_reference: SNOMEDCT_US:268308005
database_cross_reference: SNOMEDCT_US:32941003

hand, foot and mouth disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.
PMOID: PMO:00029350
Subclass_of: viral infectious disease
Synonym: (Hand, foot & mouth disease) or (vesicular stomatitis with xanthem)
Synonym: (Hand, foot & mouth disease) or (vesicular stomatitis with xanthem) (disorder)
Synonym: Disease;hand foot & mouth
Synonym: Enteroviral vesicular stomatitis with exanthem
Synonym: Enteroviral vesicular stomatitis with exanthem (disorder)
Synonym: Enteroviral vesicular stomatitis with exanthem (disorder) [Ambiguous]
Synonym: HAND FOOT MOUTH DIS
Synonym: HAND-FOOT-AND-MOUTH DISEASE
Synonym: HFMD
Synonym: Hand Foot and Mouth Disease
Tree Number: T10.7.2.4
database_cross_reference: CHV:0000005794
database_cross_reference: DO:DOID:10881
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000765
database_cross_reference: ICD10:B08.4
database_cross_reference: ICD10AM:B08.4
database_cross_reference: ICD10CM:B08.4
database_cross_reference: ICD9CM:074.3
database_cross_reference: ICPC2P:A77004
database_cross_reference: MDR:10019113
database_cross_reference: MDR:10019124
database_cross_reference: MDR:10019125
database_cross_reference: MEDCIN:30949
database_cross_reference: MEDLINEPLUS:454
database_cross_reference: MSH:D006232
database_cross_reference: MTHICD9:074.3
database_cross_reference: NCI:C128439
database_cross_reference: NCI_NICHD:C128439
database_cross_reference: NDFRT:N0000001413
database_cross_reference: RCD:XE0RN
database_cross_reference: SNM:D-0401
database_cross_reference: SNMI:DE-35040
database_cross_reference: SNOMEDCT_US:154357002
database_cross_reference: SNOMEDCT_US:175497008
database_cross_reference: SNOMEDCT_US:186664000
database_cross_reference: SNOMEDCT_US:266108008
database_cross_reference: SNOMEDCT_US:67171006

epidemic pleurodynia
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in necrosis located in intercostal muscle, has material basis in Human enterovirus B. The infection has symptom severe chest pain, has symptom fever, has symptom malaise, has symptom pleuritis, and has symptom headache.
PMOID: PMO:00029365
Subclass_of: viral infectious disease
Synonym: BORNHOLM DIS
Synonym: BORNHOLM DISEASE
Synonym: Bamble disease
Synonym: Bornholm Disease
Synonym: Bornholm disease
Synonym: Bornholms disease
Synonym: DABNEY GRIP
Synonym: DEVIL GRIP
Synonym: Devil's grip
Synonym: Disease;Bornholms
Tree Number: T10.7.2.18
database_cross_reference: CHV:0000009854
database_cross_reference: DO:DOID:10882
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001517
database_cross_reference: ICD10:B33.0
database_cross_reference: ICD10AM:B33.0
database_cross_reference: ICD10CM:B33.0
database_cross_reference: ICD9CM:074.1
database_cross_reference: ICPC2P:L70001
database_cross_reference: ICPC2P:L70004
database_cross_reference: MDR:10006035
database_cross_reference: MDR:10014978
database_cross_reference: MSH:D011000
database_cross_reference: MTHICD9:074.1
database_cross_reference: NDFRT:N0000002424
database_cross_reference: RCD:A741.
database_cross_reference: SNM:D-0388
database_cross_reference: SNMI:DE-35050
database_cross_reference: SNOMEDCT_US:154356006
database_cross_reference: SNOMEDCT_US:83264000

herpangina
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection located in mouth, has material basis in Human coxsackievirus A16, has material basis in Human enterovirus 71, has material basis in group B coxsackievirus, or has material basis in echoviruses, which are transmitted by ingestion of food contaminated with feces, transmitted by contact with pharyngeal secretions, or transmitted by droplet spread of oronasal secretions. The infection has symptom fever, has symptom sore throat, and has symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.
PMOID: PMO:00029436
Subclass_of: viral infectious disease
Synonym: Enteroviral vesic pharyngitis
Synonym: Enteroviral vesicular pharyngitis
Synonym: Enteroviral vesicular pharyngitis (disorder)
Synonym: Enteroviral vesicular pharyngitis (disorder) [Ambiguous]
Synonym: HERPANGINA
Synonym: Herpangina
Synonym: Herpangina (disorder)
Synonym: Herpangina [Disease/Finding]
Synonym: Herpanginas
Synonym: PHARYNGITIS, APHTHOUS
Tree Number: T10.7.2.68
database_cross_reference: CHV:0000006100
database_cross_reference: COSTAR:U000349
database_cross_reference: DO:DOID:10883
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000836
database_cross_reference: ICD10:B08.5
database_cross_reference: ICD10AM:B08.5
database_cross_reference: ICD10CM:B08.5
database_cross_reference: ICD9CM:074.0
database_cross_reference: ICPC2P:A77008
database_cross_reference: MDR:10019936
database_cross_reference: MDR:10067780
database_cross_reference: MEDCIN:30948
database_cross_reference: MSH:D006557
database_cross_reference: MTHICD9:074.0
database_cross_reference: NDFRT:N0000001526
database_cross_reference: RCD:A740.
database_cross_reference: SNM:D-0402
database_cross_reference: SNMI:DE-35030
database_cross_reference: SNOMEDCT_US:154358007
database_cross_reference: SNOMEDCT_US:186659004
database_cross_reference: SNOMEDCT_US:266197009
database_cross_reference: SNOMEDCT_US:274102007
database_cross_reference: SNOMEDCT_US:37428001

hypospadias
type: Class
subclass of: physical disorder
definition: A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum.
PMOID: PMO:00028264
Subclass_of: physical disorder
Synonym: HYPOSPADIA
Synonym: HYPOSPADIAS
Synonym: Hypospadia
Synonym: Hypospadias
Synonym: Hypospadias (disorder)
Synonym: Hypospadias, unspecified
Synonym: familial hypospadias
Synonym: hypospadia
Tree Number: T10.4.10
database_cross_reference: CCPSS:1017552
database_cross_reference: CHV:0000006491
database_cross_reference: COSTAR:U000376
database_cross_reference: CST:ANOMALY CONGEN
database_cross_reference: DO:DOID:10892
database_cross_reference: DXP:U002056
database_cross_reference: ICD10:Q54
database_cross_reference: ICD10:Q54.9
database_cross_reference: ICD10AM:Q54
database_cross_reference: ICD10AM:Q54.9
database_cross_reference: ICD10CM:Q54
database_cross_reference: ICD10CM:Q54.9
database_cross_reference: ICPC2EENG:Y82
database_cross_reference: LCH:U002339
database_cross_reference: LCH_NW:sh85063812
database_cross_reference: LNC:LA20090-9
database_cross_reference: MSH:D007021
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C40341
database_cross_reference: NCI_CDISC:C40341
database_cross_reference: NCI_NCI-GLOSS:CDR0000482354
database_cross_reference: NCI_NICHD:C40341
database_cross_reference: OMIM:MTHU036365
database_cross_reference: RCD:XE2Qs
database_cross_reference: SNM:M-23030
database_cross_reference: SNOMEDCT_US:416010008

microcephaly
type: Class
subclass of: congenital nervous system abnormality
PMOID: PMO:00028239
Subclass_of: congenital nervous system abnormality
Synonym: Abnormally small cranium
Synonym: Abnormally small skull
Synonym: Decreased circumference of cranium
Synonym: Decreased size of cranium
Synonym: Decreased size of skull
Synonym: MICROCEPHALY
Synonym: Micrencephaly
Synonym: Micrencephaly (disorder)
Synonym: Microcephalic
Synonym: Microcephalies
Tree Number: T10.4.1.2
database_cross_reference: AOD:0000006234
database_cross_reference: AOD:0000023640
database_cross_reference: AOD:0000023641
database_cross_reference: CCPSS:0060876
database_cross_reference: CHV:0000008093
database_cross_reference: CSP:0723-5649
database_cross_reference: CSP:0725-7823
database_cross_reference: CST:ANOMALY CONGEN CNS
database_cross_reference: DO:DOID:10907
database_cross_reference: DXP:U002575
database_cross_reference: HPO:HP:0000252
database_cross_reference: ICD10:Q02
database_cross_reference: ICD10AM:Q02
database_cross_reference: ICD10CM:Q02
database_cross_reference: ICD9CM:742.1
database_cross_reference: ICPC2P:N85007
database_cross_reference: LCH:U002961
database_cross_reference: LCH_NW:sh85084798
database_cross_reference: MDR:10027532
database_cross_reference: MDR:10027533
database_cross_reference: MDR:10027534
database_cross_reference: MDR:10068320
database_cross_reference: MEDCIN:362259
database_cross_reference: MEDCIN:98940
database_cross_reference: MSH:D008831
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:742.1
database_cross_reference: NCI:C85874
database_cross_reference: NCI_NICHD:C85874
database_cross_reference: NDFRT:N0000002010
database_cross_reference: PSY:31280
database_cross_reference: RCD:P21..
database_cross_reference: RCD:P211.
database_cross_reference: RCD:P21z.
database_cross_reference: SNM:M-21300
database_cross_reference: SNMI:D4-91050
database_cross_reference: SNOMEDCT_US:156893009
database_cross_reference: SNOMEDCT_US:1829003
database_cross_reference: SNOMEDCT_US:204030002
database_cross_reference: SNOMEDCT_US:204031003

tooth disease
type: Class
subclass of: mouth disease
PMOID: PMO:00033653
Subclass_of: mouth disease
Synonym: DISORDER TOOTH
Synonym: Disease of teeth
Synonym: Disease of teeth (disorder)
Synonym: Disease of teeth [Ambiguous]
Synonym: Disease of teeth, NOS
Synonym: Disease of tooth
Synonym: Disease, Tooth
Synonym: Disease;teeth
Synonym: Diseases, Tooth
Synonym: Disorder tooth
Tree Number: T10.8.11.11.6
database_cross_reference: CHV:0000012370
database_cross_reference: CST:TOOTH DIS
database_cross_reference: DO:DOID:1091
database_cross_reference: ICPC2P:D82004
database_cross_reference: LCH_NW:sh85133211
database_cross_reference: MDR:10013276
database_cross_reference: MDR:10044034
database_cross_reference: MDR:10044035
database_cross_reference: MEDCIN:95948
database_cross_reference: MEDLINEPLUS:3069
database_cross_reference: MSH:D014076
database_cross_reference: MTH:222
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002973
database_cross_reference: RCD:X20OO
database_cross_reference: SNM:D-6031
database_cross_reference: SNMI:D5-10000
database_cross_reference: SNOMEDCT_US:155631000
database_cross_reference: SNOMEDCT_US:234947003
database_cross_reference: SNOMEDCT_US:266485001
database_cross_reference: SNOMEDCT_US:367503003
database_cross_reference: SNOMEDCT_US:72722003

amnestic disorder
type: Class
subclass of: cognitive disorder
definition: A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information.
PMOID: PMO:00028214
Subclass_of: cognitive disorder
Synonym: AMNESIA
Synonym: Amnesia
Synonym: Amnesia (disorder)
Synonym: Amnesia (finding)
Synonym: Amnesia Memory Loss
Synonym: Amnesia NOS
Synonym: Amnesia [Disease/Finding]
Synonym: Amnesia symptom
Synonym: Amnesia, NOS
Synonym: Amnesia-Memory Loss
Tree Number: T10.3.12.4
database_cross_reference: AOD:0000006361
database_cross_reference: CCPSS:0033716
database_cross_reference: CHV:0000001032
database_cross_reference: COSTAR:048
database_cross_reference: CSP:2483-6413
database_cross_reference: CST:AMNESIA
database_cross_reference: DO:DOID:10914
database_cross_reference: DXP:U000147
database_cross_reference: ICD10CM:R41.3
database_cross_reference: ICPC2P:P20003
database_cross_reference: LCH:U000206
database_cross_reference: LCH_NW:sh85004557
database_cross_reference: MDR:10001949
database_cross_reference: MEDCIN:31986
database_cross_reference: MEDLINEPLUS:1452
database_cross_reference: MSH:D000647
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.93
database_cross_reference: NCI:C2867
database_cross_reference: NCI_CTCAE:E12585
database_cross_reference: NCI_FDA:1958
database_cross_reference: NCI_NICHD:C2867
database_cross_reference: NDFRT:N0000000371
database_cross_reference: PSY:02120
database_cross_reference: RCD:X75xY
database_cross_reference: SNM:F-93050
database_cross_reference: SNMI:F-96010
database_cross_reference: SNMI:F-96020
database_cross_reference: SNOMEDCT_US:162199006
database_cross_reference: SNOMEDCT_US:247606008
database_cross_reference: SNOMEDCT_US:386807006
database_cross_reference: SNOMEDCT_US:48167000
database_cross_reference: SNOMEDCT_US:78461004

transsexualism
type: Class
subclass of: gender identity disorder
definition: A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.
PMOID: PMO:00027935
Subclass_of: gender identity disorder
Tree Number: T10.3.4.2
database_cross_reference: DO:DOID:10919

gastrojejunal ulcer
type: Class
subclass of: peptic ulcer disease
PMOID: PMO:00033432
Subclass_of: peptic ulcer disease
Synonym: Marginal Ulcer
Synonym: Marginal Ulcers
Synonym: Marginal ulcer
Synonym: Stomal Ulcer
Synonym: Stomal ulcer
Synonym: ULCER, MARGINAL
Synonym: ULCER, STOMAL
Synonym: Ulcer, Marginal
Synonym: Ulcer, stomal
Synonym: Ulcer;marginal
Tree Number: T10.8.11.1.2
database_cross_reference: CHV:0000007750
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DXP:NOCODE
database_cross_reference: ICPC2P:D86005
database_cross_reference: MDR:10042127
database_cross_reference: MSH:D010437
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C79766
database_cross_reference: NCI_CTCAE:E11965
database_cross_reference: RCD:Xa1qA
database_cross_reference: SNM:M-38080
database_cross_reference: SNMI:D5-34510
database_cross_reference: SNOMEDCT_US:155701001
database_cross_reference: SNOMEDCT_US:16121001
database_cross_reference: SNOMEDCT_US:196706009
database_cross_reference: SNOMEDCT_US:266501005

borderline personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.
PMOID: PMO:00027902
Subclass_of: personality disorder
Synonym: BORDERLINE PERSONALITY
Synonym: BORDERLINE PERSONALITY DIS
Synonym: BPD
Synonym: Borderline Personality Disorder
Synonym: Borderline Personality Disorder [Disease/Finding]
Synonym: Borderline Personality Disorders
Synonym: Borderline personality
Synonym: Borderline personality disord
Synonym: Borderline personality disorder
Synonym: Borderline personality disorder (disorder)
Tree Number: T10.3.2.4
database_cross_reference: AOD:0000006684
database_cross_reference: CHV:0000002093
database_cross_reference: COSTAR:116
database_cross_reference: CSP:4007-0016
database_cross_reference: DO:DOID:10930
database_cross_reference: DSM-5:301.83
database_cross_reference: DSM-5:F60.3
database_cross_reference: HPO:HP:0012076
database_cross_reference: ICD10CM:F60.3
database_cross_reference: ICD9CM:301.83
database_cross_reference: LCH:U000647
database_cross_reference: LCH_NW:sh85015821
database_cross_reference: MDR:10006033
database_cross_reference: MDR:10006034
database_cross_reference: MEDCIN:32853
database_cross_reference: MEDLINEPLUS:4117
database_cross_reference: MSH:D001883
database_cross_reference: MTH:116
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92633
database_cross_reference: NCI_NCI-GLOSS:CDR0000450093
database_cross_reference: NCI_NCI-GLOSS:CDR0000457952
database_cross_reference: NDFRT:N0000000593
database_cross_reference: PSY:06622
database_cross_reference: RCD:E21y2
database_cross_reference: SNMI:D9-62200
database_cross_reference: SNOMEDCT_US:192488005
database_cross_reference: SNOMEDCT_US:20010003

dependent personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that is characterized by a pervasive psychological dependence on other people.
PMOID: PMO:00027908
Subclass_of: personality disorder
Synonym: DEPENDENT PERSONALITY DIS
Synonym: Dependent Personality Disorder
Synonym: Dependent Personality Disorder [Disease/Finding]
Synonym: Dependent Personality Disorders
Synonym: Dependent personality
Synonym: Dependent personality disorder
Synonym: Dependent personality disorder (disorder)
Synonym: Disorder, Dependent Personality
Synonym: PERSONALITY DIS DEPENDENT
Synonym: PERSONALITY DISORDER DEPENDENT
Tree Number: T10.3.2.10
database_cross_reference: AOD:0000006676
database_cross_reference: AOD:0000006679
database_cross_reference: CCPSS:0058737
database_cross_reference: CHV:0000003774
database_cross_reference: CHV:0000009547
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10931
database_cross_reference: DSM-5:301.6
database_cross_reference: DSM-5:F60.7
database_cross_reference: ICD10:F60.7
database_cross_reference: ICD10AM:F60.7
database_cross_reference: ICD10CM:F60.7
database_cross_reference: ICD9CM:301.6
database_cross_reference: ICPC2P:P80007
database_cross_reference: MDR:10012354
database_cross_reference: MDR:10012355
database_cross_reference: MDR:10034102
database_cross_reference: MEDCIN:32855
database_cross_reference: MSH:D003859
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:301.6
database_cross_reference: NCI:C92637
database_cross_reference: NDFRT:N0000000936
database_cross_reference: PSY:13625
database_cross_reference: RCD:XE1YI
database_cross_reference: SNM:F-93660
database_cross_reference: SNMI:D9-63200
database_cross_reference: SNOMEDCT_US:191768007
database_cross_reference: SNOMEDCT_US:192492003
database_cross_reference: SNOMEDCT_US:84466009

obsessive-compulsive personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that is characterized by a pervasive pattern of preoccupation with orderliness, perfectionism, and mental and interpersonal control at the expense of flexibility, openness, and efficiency.
PMOID: PMO:00027906
Subclass_of: personality disorder
Synonym: (Anankastic personality) or (anankastic personality disorder)
Synonym: (Anankastic personality) or (anankastic personality disorder) (disorder)
Synonym: Anancastic personality
Synonym: Anancastic personality disord
Synonym: Anancastic personality disorder
Synonym: Anankastic Personality
Synonym: Anankastic personality
Synonym: Anankastic personality (disorder)
Synonym: Anankastic personality disord
Synonym: Anankastic personality disorder
Tree Number: T10.3.2.8
database_cross_reference: AOD:0000006661
database_cross_reference: CCPSS:1018077
database_cross_reference: CHV:0000003252
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2483-7148
database_cross_reference: DO:DOID:10932
database_cross_reference: DSM-5:301.4
database_cross_reference: DSM-5:F60.5
database_cross_reference: ICD10:F60.5
database_cross_reference: ICD10AM:F60.5
database_cross_reference: ICD10CM:F60.5
database_cross_reference: ICD9CM:301.4
database_cross_reference: MDR:10002196
database_cross_reference: MDR:10002197
database_cross_reference: MDR:10029894
database_cross_reference: MDR:10029901
database_cross_reference: MEDCIN:32856
database_cross_reference: MSH:D003193
database_cross_reference: MTH:195
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:301.4
database_cross_reference: NCI:C92638
database_cross_reference: PSY:02395
database_cross_reference: PSY:34880
database_cross_reference: RCD:XE1YH
database_cross_reference: SNM:F-93610
database_cross_reference: SNMI:D9-63300
database_cross_reference: SNMI:F-97110
database_cross_reference: SNOMEDCT_US:112091009
database_cross_reference: SNOMEDCT_US:1376001
database_cross_reference: SNOMEDCT_US:154899005
database_cross_reference: SNOMEDCT_US:191760000
database_cross_reference: SNOMEDCT_US:191761001
database_cross_reference: SNOMEDCT_US:191762008
database_cross_reference: SNOMEDCT_US:192490006
database_cross_reference: SNOMEDCT_US:271200007

obsessive-compulsive disorder
type: Class
subclass of: anxiety disorder
definition: An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).
PMOID: PMO:00028219
Subclass_of: anxiety disorder
Synonym: -- Obsessive Compulsive Disorder
Synonym: Anancastic neurosis
Synonym: Anankastic Personalities
Synonym: Anankastic Personality
Synonym: Anankastic neurosis
Synonym: Disorder, Obsessive-Compulsive
Synonym: Disorder;obsessive-compulsive
Synonym: Disorders, Obsessive-Compulsive
Synonym: NEUROSIS, OBSESSIVE COMPULSIVE
Synonym: Neuroses, Obsessive-Compulsive
Tree Number: T10.3.12.5.1
database_cross_reference: AOD:0000006616
database_cross_reference: AOD:0000023948
database_cross_reference: AOD:0000023950
database_cross_reference: CCPSS:0045344
database_cross_reference: CHV:0000008866
database_cross_reference: COSTAR:530
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2483-7050
database_cross_reference: CST:NEUROSIS
database_cross_reference: DO:DOID:10933
database_cross_reference: DSM-5:300.3
database_cross_reference: DSM-5:F42
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001311
database_cross_reference: HPO:HP:0000722
database_cross_reference: ICD10:F42
database_cross_reference: ICD10:F42.9
database_cross_reference: ICD10AM:F42
database_cross_reference: ICD10AM:F42.9
database_cross_reference: ICD10CM:F42
database_cross_reference: ICD10CM:F42.8
database_cross_reference: ICD10CM:F42.9
database_cross_reference: ICD9CM:300.3
database_cross_reference: ICPC2P:P79003
database_cross_reference: LCH:U005868
database_cross_reference: LCH_NW:sh85093751
database_cross_reference: LNC:LA10581-9
database_cross_reference: MDR:10029898
database_cross_reference: MDR:10029899
database_cross_reference: MDR:10029900
database_cross_reference: MDR:10029902
database_cross_reference: MDR:10030029
database_cross_reference: MDR:10037961
database_cross_reference: MEDCIN:32784
database_cross_reference: MEDLINEPLUS:471
database_cross_reference: MSH:D009771
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:300.3
database_cross_reference: NCI:C88411
database_cross_reference: NCI_NCI-GLOSS:CDR0000454805
database_cross_reference: NCI_NICHD:C88411
database_cross_reference: NDFRT:N0000002203
database_cross_reference: OMIM:164230
database_cross_reference: OMIM:MTHU000246
database_cross_reference: OMIM:MTHU007292
database_cross_reference: PSY:34865
database_cross_reference: PSY:34870
database_cross_reference: RCD:E203.
database_cross_reference: RCD:E203z
database_cross_reference: RCD:Eu42z
database_cross_reference: RCDSY:Eu42z
database_cross_reference: SNM:D-9236
database_cross_reference: SNMI:D9-81500
database_cross_reference: SNOMEDCT_US:191736004
database_cross_reference: SNOMEDCT_US:191739006
database_cross_reference: SNOMEDCT_US:192406007
database_cross_reference: SNOMEDCT_US:192411009
database_cross_reference: SNOMEDCT_US:71478004

multiple personality disorder
type: Class
subclass of: dissociative disorder
definition: A dissociative disorder that involves the simultaneous display of multiple distinct identities or personalities.
PMOID: PMO:00028141
Subclass_of: dissociative disorder
Synonym: DISSOCIATIVE IDENTITY DIS
Synonym: Disorder, Dissociative Identity
Synonym: Disorder, Multiple Identity
Synonym: Disorder, Multiple Personality
Synonym: Dissociative Identity Disorder
Synonym: Dissociative identity disorder
Synonym: Dissociatve identity dis
Synonym: Identity Disorder, Dissociative
Synonym: Identity Disorder, Multiple
Synonym: MULTIPLE IDENTITY DIS
Tree Number: T10.3.8.2
database_cross_reference: AOD:0000006581
database_cross_reference: AOD:0000023922
database_cross_reference: AOD:0000023923
database_cross_reference: CCPSS:0046052
database_cross_reference: CHV:0000008330
database_cross_reference: CSP:2483-7018
database_cross_reference: DO:DOID:10934
database_cross_reference: DSM-5:300.14
database_cross_reference: DSM-5:F44.81
database_cross_reference: ICD10AM:F44.81
database_cross_reference: ICD10CM:F44.81
database_cross_reference: ICD9CM:300.14
database_cross_reference: LCH_NW:sh85088368
database_cross_reference: MDR:10013468
database_cross_reference: MDR:10028241
database_cross_reference: MDR:10028242
database_cross_reference: MEDCIN:32801
database_cross_reference: MSH:D009105
database_cross_reference: NCI:C94330
database_cross_reference: NDFRT:N0000002054
database_cross_reference: PSY:14595
database_cross_reference: PSY:32480
database_cross_reference: PSY:49330
database_cross_reference: RCD:E2019
database_cross_reference: SNM:F-93640
database_cross_reference: SNMI:D9-83100
database_cross_reference: SNOMEDCT_US:192428007
database_cross_reference: SNOMEDCT_US:31611000

dissociative disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health in which the normally well-integrated functions of memory, identity, perception, or consciousness are separated (dissociated).
PMOID: PMO:00028139
Subclass_of: disease of mental health
Synonym: 9-83 DISSOCIATIVE DISORDERS
Synonym: DISSOCIATIVE DIS
Synonym: DISSOCIATIVE DISORDER
Synonym: DISSOCIATIVE DISORDERS
Synonym: DISSOCIATIVE REACTION
Synonym: Disorder, Dissociative
Synonym: Disorder;dissociative
Synonym: Disorders, Dissociative
Synonym: Dissociation reaction
Synonym: Dissociative Disorder
Tree Number: T10.3.8
database_cross_reference: AOD:0000006583
database_cross_reference: AOD:0000023927
database_cross_reference: CCPSS:0023662
database_cross_reference: CHV:0000004035
database_cross_reference: CSP:2483-7018
database_cross_reference: CST:DEPERSONAL
database_cross_reference: DO:DOID:10935
database_cross_reference: DSM-5:300.15
database_cross_reference: DSM-5:F44.9
database_cross_reference: ICD10CM:F44.9
database_cross_reference: ICD9CM:300.15
database_cross_reference: ICPC2P:P75019
database_cross_reference: LCH_NW:sh92004916
database_cross_reference: MDR:10013460
database_cross_reference: MDR:10013462
database_cross_reference: MDR:10013463
database_cross_reference: MDR:10013464
database_cross_reference: MDR:10013465
database_cross_reference: MDR:10013469
database_cross_reference: MDR:10037943
database_cross_reference: MEDCIN:32803
database_cross_reference: MSH:D004213
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92197
database_cross_reference: NDFRT:N0000000986
database_cross_reference: PSY:14593
database_cross_reference: RCD:E201.
database_cross_reference: SNMI:D9-83000
database_cross_reference: SNOMEDCT_US:154883004
database_cross_reference: SNOMEDCT_US:44376007

schizoid personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that is characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, emotional coldness and sometimes sexual apathy, with a simultaneous rich, elaborate and exclusively internal fantasy world.
PMOID: PMO:00027900
Subclass_of: personality disorder
Synonym: Disorder, Schizoid Personality
Synonym: Disorders, Schizoid Personality
Synonym: PERSONALITY DIS SCHIZOID
Synonym: PERSONALITY DISORDER SCHIZOID
Synonym: Personalities, Schizoid
Synonym: Personality Disorder, Schizoid
Synonym: Personality Disorders, Schizoid
Synonym: Personality, Schizoid
Synonym: SCHIZOID PERSONALITY DIS
Synonym: SCHIZOID PERSONALITY DISORDER
Tree Number: T10.3.2.2
database_cross_reference: AOD:0000006649
database_cross_reference: CCPSS:0037702
database_cross_reference: CHV:0000011085
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000606
database_cross_reference: CSP:2483-7296
database_cross_reference: DO:DOID:10936
database_cross_reference: DSM-5:301.20
database_cross_reference: DSM-5:F60.1
database_cross_reference: ICD10:F60.1
database_cross_reference: ICD10AM:F60.1
database_cross_reference: ICD10CM:F60.1
database_cross_reference: ICD9CM:301.2
database_cross_reference: ICD9CM:301.20
database_cross_reference: LCH_NW:sh85118156
database_cross_reference: MDR:10039623
database_cross_reference: MDR:10039624
database_cross_reference: MDR:10039625
database_cross_reference: MEDCIN:32848
database_cross_reference: MSH:D012557
database_cross_reference: NCI:C92631
database_cross_reference: NDFRT:N0000002689
database_cross_reference: PSY:45430
database_cross_reference: RCD:E212.
database_cross_reference: RCD:E2120
database_cross_reference: RCD:E212z
database_cross_reference: SNM:F-93550
database_cross_reference: SNMI:D9-61200
database_cross_reference: SNOMEDCT_US:191756003
database_cross_reference: SNOMEDCT_US:191758002
database_cross_reference: SNOMEDCT_US:192486009
database_cross_reference: SNOMEDCT_US:52954000

impulse control disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.
PMOID: PMO:00028132
Subclass_of: disease of mental health
Synonym: 9-75 IMPULSE CONTROL DISORDERS
Synonym: Disorders, Impulse Control
Synonym: Disruptive, Impulse Control, and Conduct Disorders
Synonym: Disruptive, Impulse Control, and Conduct Disorders [Disease/Finding]
Synonym: ICD
Synonym: IMPULSE CONTROL DIS
Synonym: IMPULSE CONTROL DISORDER
Synonym: IMPULSE CONTROL DISORDERS
Synonym: Impulse Control Disorder
Synonym: Impulse Control Disorders
Tree Number: T10.3.7
database_cross_reference: AOD:0000006705
database_cross_reference: CCPSS:0048454
database_cross_reference: CHV:0000006629
database_cross_reference: DO:DOID:10937
database_cross_reference: ICD10CM:F63.9
database_cross_reference: ICD9CM:312.30
database_cross_reference: LCH_NW:sh92006420
database_cross_reference: MDR:10021561
database_cross_reference: MDR:10021562
database_cross_reference: MDR:10021564
database_cross_reference: MDR:10061215
database_cross_reference: MEDCIN:32837
database_cross_reference: MEDCIN:362651
database_cross_reference: MSH:D007174
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34723
database_cross_reference: NDFRT:N0000001673
database_cross_reference: PSY:24645
database_cross_reference: RCD:E2C30
database_cross_reference: RCD:E2C3z
database_cross_reference: SNMI:D9-75000
database_cross_reference: SNOMEDCT_US:192095006
database_cross_reference: SNOMEDCT_US:192098008
database_cross_reference: SNOMEDCT_US:66347000

paranoid personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that is characterized by paranoia and a pervasive, long-standing suspiciousness and generalized mistrust of others.
PMOID: PMO:00027905
Subclass_of: personality disorder
Synonym: Disorder, Paranoid Personality
Synonym: Disorders, Paranoid Personality
Synonym: PARANOID PERSONALITY DIS
Synonym: PERSONALITY DIS PARANOID
Synonym: PERSONALITY DISORDER PARANOID
Synonym: Paranoid Personalities
Synonym: Paranoid Personality
Synonym: Paranoid Personality Disorder
Synonym: Paranoid Personality Disorder [Disease/Finding]
Synonym: Paranoid Personality Disorders
Tree Number: T10.3.2.7
database_cross_reference: AOD:0000006638
database_cross_reference: CCPSS:1009692
database_cross_reference: CHV:0000009281
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10938
database_cross_reference: DSM-5:301.0
database_cross_reference: DSM-5:F60.0
database_cross_reference: ICD10:F60.0
database_cross_reference: ICD10AM:F60.0
database_cross_reference: ICD10CM:F60.0
database_cross_reference: ICD9CM:301.0
database_cross_reference: MDR:10033868
database_cross_reference: MDR:10033869
database_cross_reference: MEDCIN:32847
database_cross_reference: MSH:D010260
database_cross_reference: MTHICD9:301.0
database_cross_reference: NCI:C92630
database_cross_reference: NDFRT:N0000002313
database_cross_reference: PSY:36430
database_cross_reference: RCD:XE1YF
database_cross_reference: SNM:F-93590
database_cross_reference: SNMI:D9-61100
database_cross_reference: SNOMEDCT_US:13601005
database_cross_reference: SNOMEDCT_US:154896003
database_cross_reference: SNOMEDCT_US:191750009
database_cross_reference: SNOMEDCT_US:192485008
database_cross_reference: SNOMEDCT_US:270529002

antisocial personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.
PMOID: PMO:00027899
Subclass_of: personality disorder
Synonym: (Amoral personality) or (antisocial or sociopathic personality disorder)
Synonym: (Amoral personality) or (antisocial or sociopathic personality disorder) (disorder)
Synonym: Asocial personality
Synonym: Dissocial personality disorder
Synonym: Psychopath.personality
Synonym: Psychopathic personality
Synonym: Psychopathic personality disorder
Synonym: sociopathic personality
Tree Number: T10.3.2.1
database_cross_reference: DO:DOID:10939
database_cross_reference: SNOMEDCT_US:191769004

attention deficit hyperactivity disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone" and symptoms starting before seven years of age.
PMOID: PMO:00028006
Subclass_of: specific developmental disorder
Synonym: ADD
Synonym: ADD - Attention deficit disord
Synonym: ADD - Attention deficit disorder
Synonym: ADHD
Synonym: ATTENTION DEFICIT DIS
Synonym: ATTENTION DEFICIT DISORDER
Synonym: Attention Deficit Disorder
Synonym: Attention Deficit Disorders
Synonym: Attention deficit
Synonym: Attention deficit disorder
Tree Number: T10.3.5.1.9
database_cross_reference: AOD:0000006566
database_cross_reference: CCPSS:0061548
database_cross_reference: CHV:0000012719
database_cross_reference: COSTAR:U000060
database_cross_reference: CSP:0634-6981
database_cross_reference: DO:DOID:1094
database_cross_reference: MDR:10003731
database_cross_reference: MSH:D001289
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35092
database_cross_reference: OMIM:MTHU004474
database_cross_reference: OMIM:MTHU007687
database_cross_reference: OMIM:MTHU021250
database_cross_reference: PSY:04412
database_cross_reference: RCD:Ub1Tv

tongue disease
type: Class
subclass of: mouth disease
PMOID: PMO:00033644
Subclass_of: mouth disease
Synonym: 5-23 DISEASES OF THE TONGUE
Synonym: DISEASES OF THE TONGUE
Synonym: DISORDER TONGUE
Synonym: Disease of tongue
Synonym: Disease of tongue (disorder)
Synonym: Disease of tongue, NOS
Synonym: Disease of tongue, unspecified
Synonym: Disease, Tongue
Synonym: Diseases of tongue
Synonym: Diseases, Tongue
Tree Number: T10.8.11.11.5
database_cross_reference: AOD:0000005477
database_cross_reference: CHV:0000012353
database_cross_reference: CST:TONGUE DIS
database_cross_reference: DO:DOID:10944
database_cross_reference: ICD10:K14
database_cross_reference: ICD10:K14.9
database_cross_reference: ICD10AM:K14
database_cross_reference: ICD10AM:K14.9
database_cross_reference: ICD10CM:K14
database_cross_reference: ICD10CM:K14.9
database_cross_reference: ICD9CM:529.9
database_cross_reference: LCH_NW:sh85135995
database_cross_reference: MDR:10013275
database_cross_reference: MDR:10043951
database_cross_reference: MDR:10043952
database_cross_reference: MDR:10043954
database_cross_reference: MDR:10045691
database_cross_reference: MEDCIN:210399
database_cross_reference: MEDLINEPLUS:5266
database_cross_reference: MSH:D014060
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002964
database_cross_reference: RCD:J09..
database_cross_reference: RCD:J09z.
database_cross_reference: SNMI:D5-23000
database_cross_reference: SNOMEDCT_US:155533008
database_cross_reference: SNOMEDCT_US:155665004
database_cross_reference: SNOMEDCT_US:155667007
database_cross_reference: SNOMEDCT_US:196595001
database_cross_reference: SNOMEDCT_US:266496009
database_cross_reference: SNOMEDCT_US:69244009

nephritis
type: Class
subclass of: kidney disease
definition: A kidney disease that is characterized by an inflammation of the kidneys.
PMOID: PMO:00032989
Subclass_of: kidney disease
Synonym: -- Nephritis
Synonym: Inflammation of kidney
Synonym: Kidney inflammation
Synonym: NEPHRITIS
Synonym: Nephritides
Synonym: Nephritis
Synonym: Nephritis (disorder)
Synonym: Nephritis NOS
Synonym: Nephritis NOS (disorder)
Synonym: Nephritis [Disease/Finding]
Tree Number: T10.8.7.9.5
database_cross_reference: CCPSS:0050404
database_cross_reference: CHV:0000008578
database_cross_reference: CSP:1682-1154
database_cross_reference: CST:NEPHRITIS
database_cross_reference: DO:DOID:10952
database_cross_reference: DXP:U002786
database_cross_reference: HPO:HP:0000123
database_cross_reference: ICD10CM:N05
database_cross_reference: ICD10CM:N08
database_cross_reference: ICPC2P:U88004
database_cross_reference: LNC:LA10568-6
database_cross_reference: LNC:LA17784-2
database_cross_reference: MDR:10029117
database_cross_reference: MDR:10029138
database_cross_reference: MEDCIN:276549
database_cross_reference: MEDLINEPLUS:91
database_cross_reference: MSH:D009393
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:583.9
database_cross_reference: NCI:C26833
database_cross_reference: NCI_NICHD:C26833
database_cross_reference: NDFRT:N0000002147
database_cross_reference: OMIM:MTHU036910
database_cross_reference: RCD:XM0sV
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D7-12018
database_cross_reference: SNOMEDCT_US:155853001
database_cross_reference: SNOMEDCT_US:266615001
database_cross_reference: SNOMEDCT_US:274107001
database_cross_reference: SNOMEDCT_US:52845002
database_cross_reference: SNOMEDCT_VET:52845002

strongyloidiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.
PMOID: PMO:00029673
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Anguilluliases
Synonym: Anguilluliasis
Synonym: Infection by Strongyloides
Synonym: disseminated strongyloidiasis
Tree Number: T10.7.4.1.38
database_cross_reference: DO:DOID:10955
database_cross_reference: MSH:D013322

hemiplegia
type: Class
subclass of: central nervous system disease
PMOID: PMO:00030715
Subclass_of: central nervous system disease
Synonym: HEMIPLEGIA
Synonym: Hemiplegia
Synonym: Hemiplegia (disorder)
Synonym: Hemiplegia (paralysis on one side)
Synonym: Hemiplegia NOS
Synonym: Hemiplegia NOS (disorder)
Synonym: Hemiplegia [Disease/Finding]
Synonym: Hemiplegia, NOS
Synonym: Hemiplegia, unspecified
Synonym: Hemiplegias
Tree Number: T10.8.2.9.15
database_cross_reference: AOD:0000006231
database_cross_reference: CCPSS:0042724
database_cross_reference: CHV:0000005973
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3642
database_cross_reference: CST:HEMIPLEGIA
database_cross_reference: DXP:U001937
database_cross_reference: HPO:HP:0002301
database_cross_reference: ICD10:G81
database_cross_reference: ICD10:G81.9
database_cross_reference: ICD10AM:G81
database_cross_reference: ICD10AM:G81.9
database_cross_reference: ICD10CM:G81.9
database_cross_reference: ICD9CM:342.9
database_cross_reference: ICPC2P:N18003
database_cross_reference: LCH:U002141
database_cross_reference: LCH_NW:sh85060173
database_cross_reference: LNC:LA25274-4
database_cross_reference: MDR:10019468
database_cross_reference: MDR:10019473
database_cross_reference: MDR:10033826
database_cross_reference: MEDCIN:112310
database_cross_reference: MEDCIN:206402
database_cross_reference: MEDCIN:337553
database_cross_reference: MEDLINEPLUS:611
database_cross_reference: MSH:D006429
database_cross_reference: NCI:C64329
database_cross_reference: NDFRT:N0000001467
database_cross_reference: OMIM:MTHU000544
database_cross_reference: PSY:22675
database_cross_reference: RCD:F22z.
database_cross_reference: RCD:XE15T
database_cross_reference: SNM:F-81000
database_cross_reference: SNMI:DA-26010
database_cross_reference: SNOMEDCT_US:155029008
database_cross_reference: SNOMEDCT_US:192941004
database_cross_reference: SNOMEDCT_US:192946009
database_cross_reference: SNOMEDCT_US:50582007

Alport syndrome
type: Class
subclass of: monogenic disease
definition: A monogenic disease that is characterized by glomerulonephritis, endstage kidney disease, and hearing loss.
PMOID: PMO:00028387
Subclass_of: monogenic disease
Synonym: Chronic hereditary nephritis
Synonym: Familial Nephritis
Synonym: Familial nephritis
Synonym: GN - Hereditary GN
Synonym: GN - Hereditary glomerulonephritis
Synonym: Hereditary Interstitial Pyelonephritis
Synonym: Hereditary Nephritis
Synonym: Hereditary glomerulonephritis
Synonym: Hereditary nephritis
Synonym: Hereditary nephritis (disorder)
Tree Number: T10.5.3.1
database_cross_reference: CHV:0000008579
database_cross_reference: DO:DOID:10983
database_cross_reference: DXP:NOCODE
database_cross_reference: MDR:10008917
database_cross_reference: MEDCIN:97937
database_cross_reference: MSH:D009394
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002148
database_cross_reference: OMIM:MTHU031387
database_cross_reference: RCD:X30Ie
database_cross_reference: SNM:D-6718
database_cross_reference: SNMI:D7-12320
database_cross_reference: SNOMEDCT_US:399340005
database_cross_reference: SNOMEDCT_US:57333009

ovarian disease
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is located_in the ovary.
PMOID: PMO:00029816
Subclass_of: female reproductive system disease
Synonym: DISORDER OVARIAN
Synonym: Disease of ovary
Synonym: Disease of ovary (disorder)
Synonym: Disease of ovary, NOS
Synonym: Disease, Ovarian
Synonym: Diseases of Ovary
Synonym: Diseases, Ovarian
Synonym: Disorder of ovary
Synonym: Disorder of ovary (disorder)
Synonym: Disorder ovarian
Tree Number: T10.8.1.4.9
database_cross_reference: CHV:0000009120
database_cross_reference: CSP:2587-6126
database_cross_reference: CST:ENDO/OVAR
database_cross_reference: CST:ENDOOVARIAN
database_cross_reference: CST:OVAR DIS
database_cross_reference: CST:UG/FG/OVA
database_cross_reference: DO:DOID:1100
database_cross_reference: HPO:HP:0000137
database_cross_reference: LCH_NW:sh85096185
database_cross_reference: MDR:10013249
database_cross_reference: MDR:10033139
database_cross_reference: MDR:10033140
database_cross_reference: MEDCIN:90000
database_cross_reference: MEDLINEPLUS:5804
database_cross_reference: MSH:D010049
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26841
database_cross_reference: NDFRT:N0000002273
database_cross_reference: PSY:36010
database_cross_reference: RCD:X406g
database_cross_reference: SNM:D-2600
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D7-70070
database_cross_reference: SNOMEDCT_US:5552004

dissociative amnesia
type: Class
subclass of: dissociative disorder
definition: A dissociative disorder where he continuity of the patient's memory is disrupted. Patients with dissociative amnesia have recurrent episodes in which they forget important personal information or events, usually connected with trauma or severe stress.
PMOID: PMO:00028140
Subclass_of: dissociative disorder
Synonym: Amnesia neurosis
Synonym: Amnesia, Dissociative
Synonym: Amnesias, Dissociative
Synonym: Dissociative Amnesia
Synonym: Dissociative Amnesias
Synonym: Dissociative amnesia
Synonym: Dissociative amnesia (disorder)
Synonym: Psychogenic amnesia
Synonym: Psychogenic amnesia (disorder)
Synonym: amnesia dissociative
Tree Number: T10.3.8.1
database_cross_reference: AOD:0000006575
database_cross_reference: CHV:0000023731
database_cross_reference: CSP:2483-7018
database_cross_reference: DO:DOID:11037
database_cross_reference: DSM-5:300.12
database_cross_reference: DSM-5:F44.0
database_cross_reference: ICD10:F44.0
database_cross_reference: ICD10AM:F44.0
database_cross_reference: ICD10CM:F44.0
database_cross_reference: ICD9CM:300.12
database_cross_reference: MDR:10013461
database_cross_reference: MDR:10037186
database_cross_reference: MEDCIN:32799
database_cross_reference: MSH:D000647
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94328
database_cross_reference: RCD:X75xa
database_cross_reference: SNM:D-9250
database_cross_reference: SNMI:D9-83300
database_cross_reference: SNOMEDCT_US:191716000
database_cross_reference: SNOMEDCT_US:192420000
database_cross_reference: SNOMEDCT_US:84209002

depersonalization disorder
type: Class
subclass of: dissociative disorder
definition: A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization.
PMOID: PMO:00028142
Subclass_of: dissociative disorder
Synonym: Depersonalisation disorder
Synonym: Depersonalisation neurosis
Synonym: Depersonalisation syndrome
Synonym: Depersonalization Disorder
Synonym: Depersonalization Disorders
Synonym: Depersonalization disord
Synonym: Depersonalization disorder
Synonym: Depersonalization disorder (disorder)
Synonym: Depersonalization neurosis
Synonym: Depersonalization syndrome
Tree Number: T10.3.8.3
database_cross_reference: AOD:0000006621
database_cross_reference: AOD:0000023967
database_cross_reference: CHV:0000043774
database_cross_reference: CSP:2483-7018
database_cross_reference: DO:DOID:11038
database_cross_reference: ICD9CM:300.6
database_cross_reference: MDR:10012358
database_cross_reference: MDR:10012360
database_cross_reference: MEDCIN:32802
database_cross_reference: MSH:D003861
database_cross_reference: MTHICD9:300.6
database_cross_reference: NCI:C94331
database_cross_reference: RCD:E206.
database_cross_reference: RCDAE:E206.
database_cross_reference: SNM:D-9239
database_cross_reference: SNM:D-9253
database_cross_reference: SNMI:D9-83400
database_cross_reference: SNOMEDCT_US:70764005

Felty's syndrome
type: Class
subclass of: syndrome
definition: A syndrome that results_in rheumatoid arthritis, splenomegaly and neutropenia.
PMOID: PMO:00025157
Subclass_of: syndrome
Synonym: FELTY SYNDROME
Synonym: Felty Syndrome
Synonym: Felty Syndrome [Disease/Finding]
Synonym: Felty syndrome
Synonym: Felty's Syndrome
Synonym: Felty's syndrome (diagnosis)
Synonym: Felty's syndrome (disorder)
Synonym: Felty's syndrome, site unspecified
Synonym: Felty's syndrome, unspecified site
Synonym: Feltys Syndrome
Tree Number: T10.1.38
database_cross_reference: AOD:0000023281
database_cross_reference: CHV:0000004946
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:11042
database_cross_reference: DXP:U000642
database_cross_reference: ICD10:M05.0
database_cross_reference: ICD10AM:M05.0
database_cross_reference: ICD10AM:M05.09
database_cross_reference: ICD10CM:M05.0
database_cross_reference: ICD10CM:M05.00
database_cross_reference: ICD9CM:714.1
database_cross_reference: MDR:10016386
database_cross_reference: MEDCIN:31845
database_cross_reference: MSH:D005258
database_cross_reference: MTHICD9:714.1
database_cross_reference: NCI:C84712
database_cross_reference: NDFRT:N0000001223
database_cross_reference: OMIM:134750
database_cross_reference: RCD:N041.
database_cross_reference: SNM:D-3076
database_cross_reference: SNMI:D1-20610
database_cross_reference: SNOMEDCT_US:156482001
database_cross_reference: SNOMEDCT_US:57160007

gastroschisis
type: Class
subclass of: physical disorder
PMOID: PMO:00028266
Subclass_of: physical disorder
Synonym: Congenital Fissure of the Abdominal Cavity
Synonym: Eventration
Synonym: GASTROSCHISIS
Synonym: Gastroschises
Synonym: Gastroschisis
Synonym: Gastroschisis (disorder)
Synonym: Gastroschisis [Disease/Finding]
Synonym: gastroschises
Synonym: gastroschisis (diagnosis)
Tree Number: T10.4.12
database_cross_reference: CCPSS:0056066
database_cross_reference: CHV:0000025947
database_cross_reference: CST:ANOMALY CONGEN
database_cross_reference: DO:DOID:11044
database_cross_reference: HPO:HP:0001543
database_cross_reference: ICD10:Q79.3
database_cross_reference: ICD10AM:Q79.3
database_cross_reference: ICD10CM:Q79.3
database_cross_reference: ICD9CM:756.73
database_cross_reference: LNC:LA19590-1
database_cross_reference: MDR:10018046
database_cross_reference: MEDCIN:277682
database_cross_reference: MSH:D020139
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84725
database_cross_reference: NCI_CDISC:C84725
database_cross_reference: NCI_NICHD:C84725
database_cross_reference: NDFRT:N0000003997
database_cross_reference: OMIM:230750
database_cross_reference: OMIM:MTHU009129
database_cross_reference: RCD:PG71.
database_cross_reference: SNM:M-21600
database_cross_reference: SNMI:D4-16611
database_cross_reference: SNOMEDCT_US:72951007

pasteurellosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia.
PMOID: PMO:00029482
Subclass_of: primary bacterial infectious disease
Synonym: E-131 PASTEURELLOSES
Synonym: INFECT PASTEURELLA
Synonym: Infection, Pasteurella
Synonym: Infections, Pasteurella
Synonym: PASTEURELLA INFECT
Synonym: PASTEURELLOSES
Synonym: Pasteurella Infection
Synonym: Pasteurella Infections
Synonym: Pasteurella Infections [Disease/Finding]
Synonym: Pasteurella infection
Tree Number: T10.7.3.1.5
database_cross_reference: CHV:0000009344
database_cross_reference: CSP:0331-1462
database_cross_reference: CSP:0368-2318
database_cross_reference: DO:DOID:11055
database_cross_reference: ICD10:A28.0
database_cross_reference: ICD10AM:A28.0
database_cross_reference: ICD10CM:A28.0
database_cross_reference: ICD9CM:027.2
database_cross_reference: MDR:10034106
database_cross_reference: MDR:10034107
database_cross_reference: MDR:10034113
database_cross_reference: MEDCIN:360206
database_cross_reference: MSH:D010326
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002337
database_cross_reference: RCD:A272.
database_cross_reference: RCD:XE0Qt
database_cross_reference: SNM:D-0159
database_cross_reference: SNMI:DE-13100
database_cross_reference: SNOMEDCT_US:186328008
database_cross_reference: SNOMEDCT_US:266086006
database_cross_reference: SNOMEDCT_US:276199008
database_cross_reference: SNOMEDCT_US:83172007

brucellosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.
PMOID: PMO:00029504
Subclass_of: primary bacterial infectious disease
Synonym: BRUCELLOSIS
Synonym: Brucella infections
Synonym: Brucelloses
Synonym: Brucellosis
Synonym: Brucellosis (disorder)
Synonym: Brucellosis NOS
Synonym: Brucellosis NOS (disorder)
Synonym: Brucellosis [Disease/Finding]
Synonym: Brucellosis due to Brucella sp.
Synonym: Brucellosis due to Brucella sp. (disorder)
Tree Number: T10.7.3.1.14
database_cross_reference: CCPSS:0028117
database_cross_reference: CHV:0000002202
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:11077
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000265
database_cross_reference: ICD10:A23
database_cross_reference: ICD10:A23.9
database_cross_reference: ICD10AM:A23
database_cross_reference: ICD10AM:A23.9
database_cross_reference: ICD10CM:A23
database_cross_reference: ICD10CM:A23.9
database_cross_reference: ICD9CM:023
database_cross_reference: ICD9CM:023.9
database_cross_reference: ICPC2P:A78001
database_cross_reference: LCH:U000699
database_cross_reference: LCH_NW:sh85017288
database_cross_reference: LNC:LA10438-2
database_cross_reference: MDR:10006495
database_cross_reference: MDR:10006500
database_cross_reference: MDR:10006501
database_cross_reference: MDR:10026726
database_cross_reference: MDR:10027094
database_cross_reference: MDR:10045517
database_cross_reference: MDR:10045646
database_cross_reference: MEDCIN:30943
database_cross_reference: MSH:D002006
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84602
database_cross_reference: NCI_NICHD:C84602
database_cross_reference: NDFRT:N0000000627
database_cross_reference: RCD:A23..
database_cross_reference: RCD:A23z.
database_cross_reference: RCD:Ayu27
database_cross_reference: RCDSY:Ayu27
database_cross_reference: SNM:D-0116
database_cross_reference: SNMI:DE-11400
database_cross_reference: SNOMEDCT_US:111804008
database_cross_reference: SNOMEDCT_US:154296006
database_cross_reference: SNOMEDCT_US:186310006
database_cross_reference: SNOMEDCT_US:187304000
database_cross_reference: SNOMEDCT_US:75702008
database_cross_reference: SNOMEDCT_VET:75702008

leech infestation
type: Class
subclass of: parasitic ectoparasitic infectious disease
definition: A parasitic ectoparasitic infectious disease that involves parasitic infestation by members of the subclass Hirudinea. The leeches remain attached to their hosts and feed on blood until they become full, at which point they fall off to digest. While feeding, they release an anesthetic and use a combination of mucus and suction to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream.
PMOID: PMO:00029723
Subclass_of: parasitic ectoparasitic infectious disease
Synonym: (Other infectious & parasitic disease) or (infestation: [leech] or [maggot]) or (myiasis) or (toxoplasmosis)
Synonym: (Other infectious & parasitic disease) or (infestation: [leech] or [maggot]) or (myiasis) or (toxoplasmosis) (disorder)
Synonym: Hirudiniasis
Synonym: Infestation by fly larvae
Synonym: Infestation by maggots
Synonym: Leech infestation
Synonym: Leeches
Synonym: Maggot infestation
Synonym: disseminated toxoplasmosis
Synonym: myiasis
Tree Number: T10.7.4.4.3
database_cross_reference: DO:DOID:11079
database_cross_reference: DO:DOID:11080
database_cross_reference: DO:DOID:9965
database_cross_reference: SNOMEDCT_US:154423006
database_cross_reference: SNOMEDCT_US:266225001

myiasis
type: Class
subclass of: parasitic ectoparasitic infectious disease
definition: A parasitic ectoparasitic infectious disease that involves parasitic infestation by members of the subclass Hirudinea. The leeches remain attached to their hosts and feed on blood until they become full, at which point they fall off to digest. While feeding, they release an anesthetic and use a combination of mucus and suction to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream.
PMOID: PMO:00029715
Subclass_of: parasitic ectoparasitic infectious disease
Synonym: (Other infectious & parasitic disease) or (infestation: [leech] or [maggot]) or (myiasis) or (toxoplasmosis)
Synonym: (Other infectious & parasitic disease) or (infestation: [leech] or [maggot]) or (myiasis) or (toxoplasmosis) (disorder)
Synonym: Hirudiniasis
Synonym: Infestation by fly larvae
Synonym: Infestation by maggots
Synonym: Leech infestation
Synonym: Leeches
Synonym: Maggot infestation
Synonym: disseminated toxoplasmosis
Synonym: leech infestation
Tree Number: T10.7.4.4.1
database_cross_reference: DO:DOID:11079
database_cross_reference: DO:DOID:11080
database_cross_reference: DO:DOID:9965
database_cross_reference: SNOMEDCT_US:154423006
database_cross_reference: SNOMEDCT_US:266225001

asphyxia neonatorum
type: Class
subclass of: respiratory system disease
PMOID: PMO:00032455
Subclass_of: respiratory system disease
Synonym: ASPHYXIA NEONATAL
Synonym: Asphyxia - birth
Synonym: Asphyxia NOS in liveborn infant
Synonym: Asphyxia Neonatorum
Synonym: Asphyxia Neonatorum [Disease/Finding]
Synonym: Asphyxia neonatal
Synonym: Asphyxia neonatorum
Synonym: Asphyxia of newborn NOS
Synonym: Asphyxia, NOS, in liveborn infant
Synonym: Asphyxia, NOS,in liveborn infant
Tree Number: T10.8.5.1
database_cross_reference: CHV:0000001525
database_cross_reference: CSP:0726-3340
database_cross_reference: CST:ASPHYXIA
database_cross_reference: DO:DOID:11088
database_cross_reference: HPO:HP:0012768
database_cross_reference: ICD10:P21
database_cross_reference: ICD10:P21.9
database_cross_reference: ICD10AM:P21
database_cross_reference: ICD10AM:P21.9
database_cross_reference: ICD10CM:P84
database_cross_reference: ICD9CM:768.9
database_cross_reference: ICPC2P:A94003
database_cross_reference: LCH:U000399
database_cross_reference: LCH_NW:sh85008719
database_cross_reference: MDR:10003500
database_cross_reference: MDR:10004943
database_cross_reference: MDR:10028923
database_cross_reference: MDR:10046162
database_cross_reference: MSH:D001238
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:768.9
database_cross_reference: NDFRT:N0000000495
database_cross_reference: RCD:XE1el
database_cross_reference: RCD:Xa08o
database_cross_reference: SNM:F-33790
database_cross_reference: SNMI:D8-72020
database_cross_reference: SNOMEDCT_US:157098009
database_cross_reference: SNOMEDCT_US:206278008
database_cross_reference: SNOMEDCT_US:268831004
database_cross_reference: SNOMEDCT_US:268873007
database_cross_reference: SNOMEDCT_US:28314004
database_cross_reference: SNOMEDCT_US:413654009

Q fever
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.
PMOID: PMO:00029510
Subclass_of: primary bacterial infectious disease
Synonym: E-220 TYPHUS
Synonym: Endemic Typhus fever
Synonym: Exanthematic Typhus fever
Synonym: Flea typhus
Synonym: Infection due to Coxiella burnetii
Synonym: Louse-borne [epidemic] typhus
Synonym: Moscow typhus
Synonym: Murine [endemic] typhus
Synonym: TYPHUS
Synonym: Typhus
Tree Number: T10.7.3.1.16
database_cross_reference: AOD:0000004865
database_cross_reference: CHV:0000012686
database_cross_reference: CSP:2623-8052
database_cross_reference: DO:DOID:11100
database_cross_reference: DO:DOID:11256
database_cross_reference: ICD10:A75
database_cross_reference: ICD10:A75.9
database_cross_reference: ICD10AM:A75
database_cross_reference: ICD10AM:A75.9
database_cross_reference: ICD10CM:A75
database_cross_reference: ICD10CM:A75.9
database_cross_reference: ICD9CM:081.9
database_cross_reference: ICPC2P:A78026
database_cross_reference: LCH_NW:sh85139169
database_cross_reference: LNC:LP28595-4
database_cross_reference: MDR:10045276
database_cross_reference: MDR:10045277
database_cross_reference: MDR:10045278
database_cross_reference: MDR:10061393
database_cross_reference: MEDCIN:99623
database_cross_reference: MSH:D014438
database_cross_reference: MTH:U002330
database_cross_reference: MTHICD9:081.9
database_cross_reference: RCD:Ayu70
database_cross_reference: RCDSY:Ayu70
database_cross_reference: SNM:D-0337
database_cross_reference: SNMI:DE-22000
database_cross_reference: SNOMEDCT_US:154375001
database_cross_reference: SNOMEDCT_US:187383009
database_cross_reference: SNOMEDCT_US:266205000
database_cross_reference: SNOMEDCT_US:83838002

bartonellosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella.
PMOID: PMO:00029477
Subclass_of: primary bacterial infectious disease
Synonym: BARTONELLA INFECT
Synonym: BARTONELLOSIS
Synonym: Bartonella Infection
Synonym: Bartonella Infections
Synonym: Bartonella Infections [Disease/Finding]
Synonym: Bartonella infection
Synonym: Bartonella infections
Synonym: Bartonella infectious disease
Synonym: Bartonelloses
Synonym: Bartonellosis
Tree Number: T10.7.3.1.4
database_cross_reference: CHV:0000001713
database_cross_reference: CSP:2623-6984
database_cross_reference: DO:DOID:0050398
database_cross_reference: DO:DOID:11102
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000195
database_cross_reference: ICD10:A44
database_cross_reference: ICD10:A44.9
database_cross_reference: ICD10AM:A44
database_cross_reference: ICD10AM:A44.9
database_cross_reference: ICD10CM:A44
database_cross_reference: ICD10CM:A44.9
database_cross_reference: ICD9CM:088.0
database_cross_reference: LCH_NW:sh98002720
database_cross_reference: MDR:10004145
database_cross_reference: MDR:10044583
database_cross_reference: MDR:10054150
database_cross_reference: MEDCIN:30935
database_cross_reference: MSH:D001474
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84586
database_cross_reference: NCI_NICHD:C84586
database_cross_reference: NDFRT:N0000000532
database_cross_reference: RCD:Ayu3Q
database_cross_reference: RCD:X70Ip
database_cross_reference: RCD:X70OQ
database_cross_reference: RCD:XE0Rg
database_cross_reference: RCDSY:Ayu3Q
database_cross_reference: SNM:D-0311
database_cross_reference: SNMI:DE-21000
database_cross_reference: SNOMEDCT_US:17116008
database_cross_reference: SNOMEDCT_US:186824002
database_cross_reference: SNOMEDCT_US:187340003
database_cross_reference: SNOMEDCT_US:240454008
database_cross_reference: SNOMEDCT_US:240623002
database_cross_reference: SNOMEDCT_US:266123003
database_cross_reference: SNOMEDCT_VET:266123003

spotted fever
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in Rickettsia, which is transmitted by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.
PMOID: PMO:00029461
Subclass_of: primary bacterial infectious disease
Synonym: Spotted fever group rickettsial disease
Tree Number: T10.7.3.1.2
database_cross_reference: DO:DOID:11104

hydronephrosis
type: Class
subclass of: urinary tract obstruction
PMOID: PMO:00032958
Subclass_of: urinary tract obstruction
Synonym: HYDRONEPHROSIS
Synonym: Hydronephroses
Synonym: Hydronephrosis
Synonym: Hydronephrosis (disorder)
Synonym: Hydronephrosis NOS
Synonym: Hydronephrosis NOS (disorder)
Synonym: Hydronephrosis [Disease/Finding]
Synonym: Unspecified hydronephrosis
Synonym: hydronephroses
Synonym: hydronephrosis (diagnosis)
Tree Number: T10.8.7.2.3
database_cross_reference: CCPSS:0048962
database_cross_reference: CHV:0000006363
database_cross_reference: COSTAR:U000363
database_cross_reference: CSP:1682-0349
database_cross_reference: CST:HYDRONEPHROSIS
database_cross_reference: DO:DOID:11111
database_cross_reference: DXP:U000866
database_cross_reference: DXP:U002009
database_cross_reference: HPO:HP:0000126
database_cross_reference: ICD10CM:N13.30
database_cross_reference: ICD9CM:591
database_cross_reference: ICPC2P:U99021
database_cross_reference: LCH:U002285
database_cross_reference: LCH_NW:sh85063477
database_cross_reference: MDR:10020524
database_cross_reference: MEDCIN:30718
database_cross_reference: MSH:D006869
database_cross_reference: NCI:C26796
database_cross_reference: NCI_NCI-GLOSS:CDR0000044319
database_cross_reference: NCI_NICHD:C26796
database_cross_reference: NDFRT:N0000001568
database_cross_reference: OMIM:MTHU001611
database_cross_reference: RCD:K11..
database_cross_reference: RCD:K11z.
database_cross_reference: SNM:M-33300
database_cross_reference: SNMI:D7-14100
database_cross_reference: SNOMEDCT_US:155866001
database_cross_reference: SNOMEDCT_US:197791000
database_cross_reference: SNOMEDCT_US:43064006

psychologic dyspareunia
type: Class
subclass of: psychosexual disorder
PMOID: PMO:00028161
Subclass_of: psychosexual disorder
Synonym: Dyspareunia psychogenic
Synonym: Dyspareunia, psychogenic
Synonym: Dyspareunia,psychogenic
Synonym: Dyspareunia;psychogenic
Synonym: Non-organic dyspareunia
Synonym: Non-organic dyspareunia (disorder)
Synonym: Nonorganic dyspareunia
Synonym: Psychogen.dyspareunia
Synonym: Psychogenic dyspareunia
Synonym: Psychologic dyspareunia
Tree Number: T10.3.11.4.3
database_cross_reference: AOD:0000006837
database_cross_reference: DO:DOID:11120
database_cross_reference: ICD10:F52.6
database_cross_reference: ICD10AM:F52.6
database_cross_reference: ICD10CM:F52.6
database_cross_reference: ICD9CM:302.76
database_cross_reference: ICPC2P:P08003
database_cross_reference: MDR:10013945
database_cross_reference: MDR:10037193
database_cross_reference: MDR:10037225
database_cross_reference: MEDCIN:32826
database_cross_reference: RCD:E2277
database_cross_reference: SNMI:D9-73541
database_cross_reference: SNOMEDCT_US:154905005
database_cross_reference: SNOMEDCT_US:192470002
database_cross_reference: SNOMEDCT_US:268762007
database_cross_reference: SNOMEDCT_US:41021005

sarcoma
type: Class
subclass of: cell type cancer
PMOID: PMO:00025409
Subclass_of: cell type cancer
Synonym: Connective Tissue Sarcoma
Synonym: Malig tumor of soft tissue
Synonym: Malig tumour of soft tissue
Synonym: Malignant Neoplasm of Soft Tissue
Synonym: Malignant Neoplasm of the Soft Tissue
Synonym: Malignant Soft Tissue Neoplasm
Synonym: Malignant Soft Tissue Tumor
Synonym: Malignant Tumor of Soft Tissue
Synonym: Malignant Tumor of the Soft Tissue
Synonym: Malignant mesenchymal tumor
Tree Number: T10.2.1.1.9
database_cross_reference: AOD:0000004530
database_cross_reference: CCPSS:0020102
database_cross_reference: CCPSS:0046778
database_cross_reference: CHV:0000042636
database_cross_reference: CHV:0000056478
database_cross_reference: COSTAR:U000602
database_cross_reference: CSP:2000-8986
database_cross_reference: CST:SARCOMA
database_cross_reference: DO:DOID:0050652
database_cross_reference: HPO:HP:0030448
database_cross_reference: HPO:HP:0100242
database_cross_reference: ICD10AM:M8800/3
database_cross_reference: ICPC2P:A79013
database_cross_reference: ICPC2P:L71011
database_cross_reference: LCH:U004213
database_cross_reference: LCH_NW:sh85117504
database_cross_reference: MDR:10026699
database_cross_reference: MDR:10039491
database_cross_reference: MDR:10039494
database_cross_reference: MDR:10061271
database_cross_reference: MDR:10073145
database_cross_reference: MDR:10075333
database_cross_reference: MEDCIN:231737
database_cross_reference: MEDCIN:231878
database_cross_reference: MEDCIN:271492
database_cross_reference: MEDLINEPLUS:495
database_cross_reference: MSH:D012509
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4867
database_cross_reference: NCI:C9118
database_cross_reference: NCI:C9306
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C9118
database_cross_reference: NCI_CTEP-SDC:10039494
database_cross_reference: NCI_NCI-GLOSS:CDR0000045562
database_cross_reference: NCI_NCI-GLOSS:CDR0000046584
database_cross_reference: NCI_NICHD:C9118
database_cross_reference: NCI_NICHD:C9306
database_cross_reference: NDFRT:N0000002671
database_cross_reference: OMIM:MTHU017412
database_cross_reference: OMIM:MTHU022273
database_cross_reference: PDQ:CDR0000039253
database_cross_reference: PSY:45270
database_cross_reference: RCD:BBF1.
database_cross_reference: RCD:XE1vg
database_cross_reference: RCD:Xa97s
database_cross_reference: RCD:Xa99e
database_cross_reference: RCDAE:Xa97s
database_cross_reference: RCDAE:Xa99e
database_cross_reference: RCDSY:BBF1.
database_cross_reference: SNM:M-8800/3
database_cross_reference: SNMI:M-88003
database_cross_reference: SNOMEDCT_US:189764008
database_cross_reference: SNOMEDCT_US:2424003
database_cross_reference: SNOMEDCT_US:269469005
database_cross_reference: SNOMEDCT_US:269634000
database_cross_reference: SNOMEDCT_US:363362006
database_cross_reference: SNOMEDCT_US:424413001
database_cross_reference: SNOMEDCT_US:424952003
database_cross_reference: SNOMEDCT_US:93765001

cholecystolithiasis
type: Class
subclass of: gallbladder disease
PMOID: PMO:00033634
Subclass_of: gallbladder disease
Synonym: Biliary Calculi
Synonym: Biliary calculus
Synonym: Biliary calculus (disorder)
Synonym: Biliary calculus (disorder) [Ambiguous]
Synonym: Biliary calculus, NOS
Synonym: Biliary stones
Synonym: CHOLELITHIASIS
Synonym: CL - Cholelithiasis
Synonym: Calculus - biliary
Synonym: Calculus biliary
Tree Number: T10.8.11.10.2
database_cross_reference: AOD:0000005679
database_cross_reference: AOD:0000005681
database_cross_reference: BI:BI00219
database_cross_reference: CCPSS:0060028
database_cross_reference: CHV:0000002871
database_cross_reference: COSTAR:177
database_cross_reference: CSP:0413-4335
database_cross_reference: CST:CHOLELITH
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000338
database_cross_reference: DXP:U001637
database_cross_reference: HPO:HP:0001081
database_cross_reference: ICD10:K80
database_cross_reference: ICD10AM:K80
database_cross_reference: ICD10CM:K80
database_cross_reference: ICD9CM:574
database_cross_reference: ICPC2P:D98007
database_cross_reference: ICPC2P:D98010
database_cross_reference: LNC:LA14289-5
database_cross_reference: MDR:10004674
database_cross_reference: MDR:10006986
database_cross_reference: MDR:10008629
database_cross_reference: MDR:10017650
database_cross_reference: MEDCIN:30048
database_cross_reference: MEDLINEPLUS:4643
database_cross_reference: MSH:D002769
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C122822
database_cross_reference: NCI_NICHD:C122822
database_cross_reference: NDFRT:N0000000760
database_cross_reference: NDFRT:N0000011058
database_cross_reference: OMIM:MTHU009745
database_cross_reference: RCD:J64z.
database_cross_reference: RCD:XE0bD
database_cross_reference: SNM:M-30010
database_cross_reference: SNMI:D5-85500
database_cross_reference: SNOMEDCT_US:155823008
database_cross_reference: SNOMEDCT_US:197376000
database_cross_reference: SNOMEDCT_US:197403005
database_cross_reference: SNOMEDCT_US:197406002
database_cross_reference: SNOMEDCT_US:266474003
database_cross_reference: SNOMEDCT_US:266541001
database_cross_reference: SNOMEDCT_US:44900007

pertussis
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).
PMOID: PMO:00029608
Subclass_of: commensal bacterial infectious disease
Synonym: BORDETELLA INFECT
Synonym: BORDETELLOSES
Synonym: Bordetella Infection
Synonym: Bordetella Infections
Synonym: Bordetella Infections [Disease/Finding]
Synonym: Bordetella infection
Synonym: Bordetella infections
Synonym: Bordetellosis
Synonym: Bordetellosis (diagnosis)
Synonym: Bordetellosis (disorder)
Tree Number: T10.7.3.3.9
database_cross_reference: CHV:0000002095
database_cross_reference: DO:DOID:1116
database_cross_reference: MDR:10006024
database_cross_reference: MDR:10052307
database_cross_reference: MEDCIN:354527
database_cross_reference: MSH:D001885
database_cross_reference: NDFRT:N0000000594
database_cross_reference: RCD:X70I8
database_cross_reference: SNMI:DE-13200
database_cross_reference: SNOMEDCT_US:26484003

common wart
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.
PMOID: PMO:00029395
Subclass_of: viral infectious disease
Synonym: 766 VERRUCAE
Synonym: Common Wart
Synonym: Common wart
Synonym: Common warts
Synonym: Human papilloma virus inf,skin
Synonym: Human papilloma virus infection of skin
Synonym: Infectious wart
Synonym: Infectious warts
Synonym: SKIN LESION, VERRUCOUS
Synonym: SKIN LESION, WARTLIKE
Tree Number: T10.7.2.39
database_cross_reference: CCPSS:0018538
database_cross_reference: CHV:0000013107
database_cross_reference: CHV:0000028397
database_cross_reference: COSTAR:785
database_cross_reference: COSTAR:786
database_cross_reference: COSTAR:U000612
database_cross_reference: CSP:3118-7534
database_cross_reference: CST:NEOPL SKIN
database_cross_reference: DO:DOID:11165
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U003651
database_cross_reference: ICD10:B07
database_cross_reference: ICD10AM:B07
database_cross_reference: ICD10CM:B07
database_cross_reference: ICD10CM:B07.8
database_cross_reference: ICD9CM:078.1
database_cross_reference: ICPC2P:S03003
database_cross_reference: ICPC2P:S03004
database_cross_reference: MDR:10010114
database_cross_reference: MDR:10010115
database_cross_reference: MDR:10047320
database_cross_reference: MDR:10047322
database_cross_reference: MDR:10047484
database_cross_reference: MDR:10047829
database_cross_reference: MEDCIN:31075
database_cross_reference: MEDCIN:31076
database_cross_reference: MEDCIN:6296
database_cross_reference: MEDLINEPLUS:459
database_cross_reference: MTH:785
database_cross_reference: MTH:786
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:078.1
database_cross_reference: MTHICD9:078.10
database_cross_reference: MTHICD9:078.19
database_cross_reference: NCI:C27087
database_cross_reference: NCI:C5028
database_cross_reference: NCI_NICHD:C27087
database_cross_reference: NCI_NICHD:C5028
database_cross_reference: NDFRT:N0000003152
database_cross_reference: OMIM:MTHU037668
database_cross_reference: RCD:A7810
database_cross_reference: RCD:A7811
database_cross_reference: RCD:XE0RS
database_cross_reference: SNM:M-76600
database_cross_reference: SNM:M-76630
database_cross_reference: SNM:U000383
database_cross_reference: SNMI:DE-32A10
database_cross_reference: SNMI:DE-32A11
database_cross_reference: SNMI:M-76600
database_cross_reference: SNOMEDCT_US:123201004
database_cross_reference: SNOMEDCT_US:154361008
database_cross_reference: SNOMEDCT_US:186685000
database_cross_reference: SNOMEDCT_US:186686004
database_cross_reference: SNOMEDCT_US:266198004
database_cross_reference: SNOMEDCT_US:30285000
database_cross_reference: SNOMEDCT_US:367507002
database_cross_reference: SNOMEDCT_US:57019003
database_cross_reference: SNOMEDCT_US:75003008

anogenital venereal wart
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.
PMOID: PMO:00029447
Subclass_of: viral infectious disease
Synonym: AGW - Anogenital warts
Synonym: Anogenital (venereal) warts
Synonym: Anogenital Human papilloma Virus Infectious Disease
Synonym: Anogenital wart
Synonym: Anogenital warts
Synonym: Anogenital warts (disorder)
Synonym: CONDYLOMA ACCUMINATA
Synonym: CONDYLOMA ACUMINATA
Synonym: CONDYLOMA ACUMINATUM
Synonym: Condyloma
Tree Number: T10.7.2.78
database_cross_reference: BI:BI00467
database_cross_reference: CCPSS:0036478
database_cross_reference: CHV:0000003267
database_cross_reference: COSTAR:196
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2020-4312
database_cross_reference: DO:DOID:11168
database_cross_reference: DXP:U000390
database_cross_reference: ICD10:A63.0
database_cross_reference: ICD10AM:A63.0
database_cross_reference: ICD10CM:A63.0
database_cross_reference: ICD9CM:078.11
database_cross_reference: LCH_NW:sh90002382
database_cross_reference: MDR:10010291
database_cross_reference: MDR:10010294
database_cross_reference: MDR:10010295
database_cross_reference: MDR:10018182
database_cross_reference: MDR:10047202
database_cross_reference: MDR:10048423
database_cross_reference: MDR:10059313
database_cross_reference: MEDCIN:31138
database_cross_reference: MEDCIN:91760
database_cross_reference: MEDLINEPLUS:4322
database_cross_reference: MSH:D003218
database_cross_reference: MTH:196
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:078.11
database_cross_reference: NCI:C2960
database_cross_reference: NCI_NCI-GLOSS:CDR0000409765
database_cross_reference: NCI_NCI-GLOSS:CDR0000409827
database_cross_reference: NCI_NICHD:C2960
database_cross_reference: NDFRT:N0000000829
database_cross_reference: RCD:X70LZ
database_cross_reference: RCD:XE0RT
database_cross_reference: SNM:M-76720
database_cross_reference: SNMI:DE-32A20
database_cross_reference: SNOMEDCT_US:123157002
database_cross_reference: SNOMEDCT_US:154361008
database_cross_reference: SNOMEDCT_US:154365004
database_cross_reference: SNOMEDCT_US:186688003
database_cross_reference: SNOMEDCT_US:22020001
database_cross_reference: SNOMEDCT_US:240542006
database_cross_reference: SNOMEDCT_US:266113007
database_cross_reference: SNOMEDCT_US:266198004

acute laryngopharyngitis
type: Class
subclass of: upper respiratory tract disease
definition: An upper respiratory tract disease which involves inflammation of both larynx and pharynx.
PMOID: PMO:00032504
Subclass_of: upper respiratory tract disease
Synonym: Acute laryngopharyngitis
Synonym: Acute laryngopharyngitis (disorder)
Synonym: acute laryngopharyngitis (diagnosis)
Synonym: laryngopharyngitis acute
Tree Number: T10.8.5.2.14
database_cross_reference: DO:DOID:11195
database_cross_reference: ICD10:J06.0
database_cross_reference: ICD10AM:J06.0
database_cross_reference: ICD10CM:J06.0
database_cross_reference: ICD9CM:465.0
database_cross_reference: MDR:10000826
database_cross_reference: MEDCIN:34103
database_cross_reference: RCD:H050.
database_cross_reference: SNMI:D2-04300
database_cross_reference: SNOMEDCT_US:55355000

DiGeorge syndrome
type: Class
subclass of: chromosomal deletion syndrome
definition: A T cell deficiency disease that is the result of a large deletion of chromosome 22 which includes the DGS gene needed for development of the thymus and related glands with subsequent lack of T-cell production.
PMOID: PMO:00028797
Subclass_of: chromosomal deletion syndrome
Synonym: 22q11.2 Deletion Syndrome
Synonym: 3rd+4th pharyngeal pouch syndr
Synonym: Agenesis of the parathyroid AND thymus glands
Synonym: Agenesis of the parathyroid and thymus glands
Synonym: Autosomal Dominant Opitz G Bbb Syndrome
Synonym: Autosomal Dominant Opitz G-Bbb Syndrome
Synonym: Branchial arch syndrome
Synonym: CATCH22
Synonym: CHROMOSOME 22q11.2 DELETION SYNDROME
Synonym: Catch22
Tree Number: T10.5.9.8.20
database_cross_reference: CHV:0000003934
database_cross_reference: CSP:0427-9991
database_cross_reference: DO:DOID:11198
database_cross_reference: DRUGBANK:DB06804
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:D82.1
database_cross_reference: ICD10AM:D82.1
database_cross_reference: ICD10CM:D82.1
database_cross_reference: ICD9CM:279.11
database_cross_reference: JABL:268
database_cross_reference: JABL:73
database_cross_reference: MDR:10012979
database_cross_reference: MDR:10043664
database_cross_reference: MEDCIN:362065
database_cross_reference: MSH:D004062
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:279.11
database_cross_reference: NCI:C2989
database_cross_reference: NCI_NICHD:C2989
database_cross_reference: NDFRT:N0000000971
database_cross_reference: OMIM:188400
database_cross_reference: OMIM:602054
database_cross_reference: RCD:C3911
database_cross_reference: SNM:D-4607
database_cross_reference: SNMI:D4-01532
database_cross_reference: SNOMEDCT_US:190991007
database_cross_reference: SNOMEDCT_US:77128003

hypoparathyroidism
type: Class
subclass of: parathyroid gland disease
definition: A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood.
PMOID: PMO:00033108
Subclass_of: parathyroid gland disease
Synonym: Deficiency of PTH
Synonym: Deficiency of parathyrin
Synonym: Deficiency of parathyroid hormone
Synonym: HYPOPARATHYROID
Synonym: HYPOPARATHYROIDISM
Synonym: Hypoparathyroidism
Synonym: Hypoparathyroidism (disorder)
Synonym: Hypoparathyroidism NOS
Synonym: Hypoparathyroidism NOS (disorder)
Synonym: Hypoparathyroidism [Disease/Finding]
Tree Number: T10.8.8.1.1
database_cross_reference: AOD:0000005996
database_cross_reference: CCPSS:0052780
database_cross_reference: CHV:0000006483
database_cross_reference: COSTAR:U000374
database_cross_reference: CSP:2216-0711
database_cross_reference: CST:PARATHYR DIS
database_cross_reference: DO:DOID:11199
database_cross_reference: DXP:U000907
database_cross_reference: DXP:U002052
database_cross_reference: HPO:HP:0000829
database_cross_reference: ICD10:E20
database_cross_reference: ICD10:E20.9
database_cross_reference: ICD10AM:E20
database_cross_reference: ICD10AM:E20.9
database_cross_reference: ICD10CM:E20
database_cross_reference: ICD10CM:E20.9
database_cross_reference: ICD9CM:252.1
database_cross_reference: ICPC2P:T99030
database_cross_reference: LCH:U002334
database_cross_reference: LCH_NW:sh85063800
database_cross_reference: MDR:10021041
database_cross_reference: MEDCIN:30512
database_cross_reference: MEDLINEPLUS:356
database_cross_reference: MSH:D007011
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78350
database_cross_reference: NCI_CTCAE:E10328
database_cross_reference: NCI_NICHD:C78350
database_cross_reference: NDFRT:N0000001641
database_cross_reference: OMIM:MTHU006713
database_cross_reference: PSY:24020
database_cross_reference: RCD:C121.
database_cross_reference: RCD:C121z
database_cross_reference: SNM:D-2270
database_cross_reference: SNMI:DB-90500
database_cross_reference: SNOMEDCT_US:154697005
database_cross_reference: SNOMEDCT_US:190457001
database_cross_reference: SNOMEDCT_US:267479004
database_cross_reference: SNOMEDCT_US:36976004

T cell deficiency
type: Class
subclass of: primary immunodeficiency disease
PMOID: PMO:00032617
Subclass_of: primary immunodeficiency disease
Synonym: Congenital T-Cell Immunodeficiency
Tree Number: T10.8.6.1.1
database_cross_reference: DO:DOID:11200
database_cross_reference: NCI:C27872

parathyroid gland disease
type: Class
subclass of: endocrine system disease
definition: An endocrine system disease that is located_in the parathyroid gland.
PMOID: PMO:00033107
Subclass_of: endocrine system disease
Synonym: DISEASES OF THE PARATHYROID GLANDS
Synonym: DISORDER PARATHYROID
Synonym: DYSFUNCTION PARATHYROID
Synonym: Disease of parathyroid glands
Synonym: Disease of parathyroid glands (disorder)
Synonym: Disease of parathyroid glands, NOS
Synonym: Disease, Parathyroid
Synonym: Diseases of Parathyroid Glands
Synonym: Diseases, Parathyroid
Synonym: Disorder of parathyroid gland
Tree Number: T10.8.8.1
database_cross_reference: AOD:0000005994
database_cross_reference: CCPSS:0044905
database_cross_reference: CHV:0000009300
database_cross_reference: CSP:2215-9463
database_cross_reference: CST:ENDO/PARATHYR
database_cross_reference: CST:ENDOPARATHYR
database_cross_reference: CST:PARATHYR DIS
database_cross_reference: DO:DOID:11201
database_cross_reference: HPO:HP:0000828
database_cross_reference: ICD10:E21.5
database_cross_reference: ICD10AM:E21.5
database_cross_reference: ICD10CM:E21.5
database_cross_reference: ICD9CM:252
database_cross_reference: ICD9CM:252.9
database_cross_reference: ICPC2P:T99049
database_cross_reference: LCH_NW:sh85097935
database_cross_reference: MDR:10013251
database_cross_reference: MDR:10013343
database_cross_reference: MDR:10013905
database_cross_reference: MDR:10033932
database_cross_reference: MDR:10033942
database_cross_reference: MDR:10033943
database_cross_reference: MDR:10033945
database_cross_reference: MDR:10033949
database_cross_reference: MDR:10045819
database_cross_reference: MEDCIN:99856
database_cross_reference: MEDLINEPLUS:356
database_cross_reference: MSH:D010279
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26844
database_cross_reference: NDFRT:N0000002321
database_cross_reference: PSY:36540
database_cross_reference: RCD:C12..
database_cross_reference: RCD:C12z.
database_cross_reference: SNM:D-2260
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DB-90000
database_cross_reference: SNOMEDCT_US:190462000
database_cross_reference: SNOMEDCT_US:267478007
database_cross_reference: SNOMEDCT_US:73132005

opioid abuse
type: Class
subclass of: substance abuse
definition: A substance abuse that involves the recurring use of opioid drugs despite negative consequences.
PMOID: PMO:00027920
Subclass_of: substance abuse
Synonym: OPIATE ABUSE
Synonym: Opioid abuse
Synonym: Opioid abuse (disorder)
Synonym: abuse opioids
Synonym: opiate abuse
Synonym: opioid abuse (diagnosis)
Tree Number: T10.3.3.2.8
database_cross_reference: CCPSS:1017306
database_cross_reference: CHV:0000008969
database_cross_reference: DO:DOID:11206
database_cross_reference: ICD10CM:F11.1
database_cross_reference: ICD9CM:305.5
database_cross_reference: MDR:10030887
database_cross_reference: MEDCIN:32699
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:D9-30800
database_cross_reference: SNOMEDCT_US:5602001

small intestine diverticulitis
type: Class
subclass of: intestinal disease
PMOID: PMO:00033593
Subclass_of: intestinal disease
Synonym: Diverticulosis of small intestine with haemorrhage
Synonym: Diverticulosis of small intestine with hemorrhage
Synonym: Diverticulosis of small intestine with hemorrhage (disorder)
Synonym: Dvrtclo sml int w hmrhg
Synonym: diverticulosis of small intestine with hemorrhage
Synonym: diverticulosis of small intestine with hemorrhage (diagnosis)
Tree Number: T10.8.11.8.14
database_cross_reference: DO:DOID:11223
database_cross_reference: ICD9CM:562.02
database_cross_reference: MDR:10013553
database_cross_reference: MDR:10055784
database_cross_reference: MEDCIN:96173
database_cross_reference: SNOMEDCT_US:435061000124102

acute hemorrhagic conjunctivitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in inflammation located in conjunctiva, has material basis in Human coxsackievirus A24 or has material basis in Human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. The infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis.
PMOID: PMO:00029453
Subclass_of: viral infectious disease
Synonym: AHC - Ac haemorrh conjunctivit
Synonym: AHC - Acute haemorrhagic conjunctivitis
Synonym: AHC - Acute hemorrhagic conjunctivitis
Synonym: Acute Hemorrhagic Conjunctivitides
Synonym: Acute Hemorrhagic Conjunctivitis
Synonym: Acute haemorr conjunctivitis
Synonym: Acute haemorrhagic conjunctivitis
Synonym: Acute hemorrhagic conjunctivitis
Synonym: Acute hemorrhagic conjunctivitis (disorder)
Synonym: Apollo conjunctivitis
Tree Number: T10.7.2.82
database_cross_reference: DO:DOID:11227
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000400
database_cross_reference: ICD9CM:077.4
database_cross_reference: LCH_NW:sh89002254
database_cross_reference: MDR:10014973
database_cross_reference: MDR:10014974
database_cross_reference: MDR:10067817
database_cross_reference: MDR:10067818
database_cross_reference: MEDCIN:273200
database_cross_reference: MEDCIN:30995
database_cross_reference: MSH:D003232
database_cross_reference: MTHICD9:077.4
database_cross_reference: NCI:C34505
database_cross_reference: NDFRT:N0000000834
database_cross_reference: RCD:A774.
database_cross_reference: RCDAE:A774.
database_cross_reference: SNM:D-0519
database_cross_reference: SNMI:DE-35060
database_cross_reference: SNOMEDCT_US:186677009
database_cross_reference: SNOMEDCT_US:31502007
database_cross_reference: SNOMEDCT_US:398264003
database_cross_reference: SNOMEDCT_US:398273006

neonatal anemia
type: Class
subclass of: anemia
PMOID: PMO:00033369
Subclass_of: anemia
Synonym: ANAEMIA NEONATAL
Synonym: ANEMIA NEONATAL
Synonym: Anaemia neonatal
Synonym: Anemia Neonatorum
Synonym: Anemia neonatal
Synonym: Anemia, Neonatal
Synonym: Anemia, Neonatal [Disease/Finding]
Synonym: Anemias, Neonatal
Synonym: Neonatal Anemia
Synonym: Neonatal Anemias
Tree Number: T10.8.10.4.7
database_cross_reference: CHV:0000001131
database_cross_reference: CST:ANEMIA
database_cross_reference: DO:DOID:11244
database_cross_reference: MDR:10002068
database_cross_reference: MDR:10002300
database_cross_reference: MSH:D000751
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000395
database_cross_reference: RCD:X20Bx
database_cross_reference: RCDAE:X20Bx
database_cross_reference: SNMI:D8-74300
database_cross_reference: SNOMEDCT_US:111468003
database_cross_reference: SNOMEDCT_US:234350007
database_cross_reference: SNOMEDCT_US:276577009
database_cross_reference: SNOMEDCT_US:33130007

microcytic anemia
type: Class
subclass of: anemia
PMOID: PMO:00033365
Subclass_of: anemia
Synonym: ANEMIA MICROCYTIC
Synonym: ANEMIA, HYPOCHROMIC MICROCYTIC, WITH DEFECT IN IRON METABOLISM
Synonym: Anaemia microcytic
Synonym: Anaemia;microcytic
Synonym: Anemia microcytic
Synonym: Anemia, Hypochromic Microcytic, with Defect in Iron Metabolism
Synonym: Anemia;microcytic
Synonym: IRIDA
Synonym: IRIDA (iron-refractory iron deficiency anaemia) syndrome
Synonym: IRIDA (iron-refractory iron deficiency anemia) syndrome
Tree Number: T10.8.10.4.5
database_cross_reference: AOD:0000005875
database_cross_reference: BI:BI00291
database_cross_reference: CCPSS:0061973
database_cross_reference: CHV:0000015663
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0427-2389
database_cross_reference: CST:ANEMIA MICROCYT
database_cross_reference: DO:DOID:11252
database_cross_reference: HPO:HP:0001935
database_cross_reference: ICPC2P:B80003
database_cross_reference: MDR:10002066
database_cross_reference: MDR:10002299
database_cross_reference: MDR:10027538
database_cross_reference: MDR:10027539
database_cross_reference: MSH:C562385
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35141
database_cross_reference: OMIM:206200
database_cross_reference: OMIM:609862
database_cross_reference: OMIM:MTHU006439
database_cross_reference: RCD:X20Bw
database_cross_reference: RCDAE:X20Bw
database_cross_reference: SNM:D-4014
database_cross_reference: SNOMEDCT_US:154787005
database_cross_reference: SNOMEDCT_US:234349007
database_cross_reference: SNOMEDCT_US:267553005
database_cross_reference: SNOMEDCT_US:722005000

typhus
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.
PMOID: PMO:00029483
Subclass_of: primary bacterial infectious disease
Synonym: E-220 TYPHUS
Synonym: Endemic Typhus fever
Synonym: Exanthematic Typhus fever
Synonym: Flea typhus
Synonym: Infection due to Coxiella burnetii
Synonym: Louse-borne [epidemic] typhus
Synonym: Moscow typhus
Synonym: Murine [endemic] typhus
Synonym: Q fever
Synonym: TYPHUS
Tree Number: T10.7.3.1.6
database_cross_reference: AOD:0000004865
database_cross_reference: CHV:0000012686
database_cross_reference: CSP:2623-8052
database_cross_reference: DO:DOID:11100
database_cross_reference: DO:DOID:11256
database_cross_reference: ICD10:A75
database_cross_reference: ICD10:A75.9
database_cross_reference: ICD10AM:A75
database_cross_reference: ICD10AM:A75.9
database_cross_reference: ICD10CM:A75
database_cross_reference: ICD10CM:A75.9
database_cross_reference: ICD9CM:081.9
database_cross_reference: ICPC2P:A78026
database_cross_reference: LCH_NW:sh85139169
database_cross_reference: LNC:LP28595-4
database_cross_reference: MDR:10045276
database_cross_reference: MDR:10045277
database_cross_reference: MDR:10045278
database_cross_reference: MDR:10061393
database_cross_reference: MEDCIN:99623
database_cross_reference: MSH:D014438
database_cross_reference: MTH:U002330
database_cross_reference: MTHICD9:081.9
database_cross_reference: RCD:Ayu70
database_cross_reference: RCDSY:Ayu70
database_cross_reference: SNM:D-0337
database_cross_reference: SNMI:DE-22000
database_cross_reference: SNOMEDCT_US:154375001
database_cross_reference: SNOMEDCT_US:187383009
database_cross_reference: SNOMEDCT_US:266205000
database_cross_reference: SNOMEDCT_US:83838002

rabies
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in inflammation located in brain or located in spinal cord, has material basis in Rabies virus, which is transmitted by bite of an infected animal, or transmitted by contact of mucous membranes with saliva of an infected animal. The infection has symptom fever, has symptom headache, has symptom prickling or itching sensation at the site of bite, has symptom anxiety, has symptom confusion, has symptom agitation, has symptom delirium, has symptom difficulty swallowing, has symptom hydrophobia, and has symptom paralysis.
PMOID: PMO:00029357
Subclass_of: viral infectious disease
Synonym: HYDROPHOBIA
Synonym: Hydrophobia
Synonym: Hydrophobia (finding)
Synonym: Infection due to Rabies virus
Synonym: LYSSA
Synonym: Lyssa
Synonym: Lyssa - rabies
Synonym: Lyssas
Synonym: RABIES
Synonym: Rabies
Tree Number: T10.7.2.10
database_cross_reference: AOD:0000004827
database_cross_reference: CHV:0000010507
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2042-5777
database_cross_reference: DO:DOID:11260
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001641
database_cross_reference: ICD10:A82
database_cross_reference: ICD10:A82.9
database_cross_reference: ICD10AM:A82
database_cross_reference: ICD10AM:A82.9
database_cross_reference: ICD10CM:A82
database_cross_reference: ICD10CM:A82.9
database_cross_reference: ICD9CM:071
database_cross_reference: ICPC2P:A77012
database_cross_reference: LCH:U004002
database_cross_reference: LCH_NW:sh85110217
database_cross_reference: MDR:10037742
database_cross_reference: MDR:10037743
database_cross_reference: MDR:10037744
database_cross_reference: MEDCIN:31023
database_cross_reference: MEDLINEPLUS:523
database_cross_reference: MSH:D011818
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:071
database_cross_reference: NCI:C28182
database_cross_reference: NCI_NCI-GLOSS:CDR0000044617
database_cross_reference: NCI_NICHD:C28182
database_cross_reference: NDFRT:N0000002567
database_cross_reference: RCD:Ayu84
database_cross_reference: RCD:XE2uG
database_cross_reference: RCDSY:Ayu84
database_cross_reference: SNM:D-0459
database_cross_reference: SNMI:DE-34410
database_cross_reference: SNOMEDCT_US:14168008
database_cross_reference: SNOMEDCT_US:186644005
database_cross_reference: SNOMEDCT_US:187393002
database_cross_reference: SNOMEDCT_US:275370001
database_cross_reference: SNOMEDCT_VET:14168008

ornithosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia.
PMOID: PMO:00029533
Subclass_of: primary bacterial infectious disease
Synonym: AIDS & viral/chlamyd dis NOS
Synonym: AIDS with viral/chlamydial disease NOS
Synonym: AIDS with viral/chlamydial disease NOS (disorder)
Synonym: Acquired immunodeficiency syndrome (AIDS) with viral/chlamydial disease NOS
Synonym: Acquired immunodeficiency syndrome (AIDS) with viral/chlamydial disease NOS (disorder)
Synonym: Aids +viral/chlamydial dis.NOS
Synonym: psittacosis
Tree Number: T10.7.3.1.28
database_cross_reference: DO:DOID:11262
database_cross_reference: RCD:Xa3e8
database_cross_reference: SNOMEDCT_US:154367007
database_cross_reference: SNOMEDCT_US:266200005
database_cross_reference: SNOMEDCT_US:286880007

chlamydia
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that is caused by Chlamydia trachomatis.
PMOID: PMO:00029601
Subclass_of: commensal bacterial infectious disease
Synonym: Chlamydia trachomatis infectious disease
Synonym: Chlamydial Infection
Synonym: chlamydial disease
Tree Number: T10.7.3.3.2
database_cross_reference: DO:DOID:11263

trachoma
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.
PMOID: PMO:00029605
Subclass_of: commensal bacterial infectious disease
Synonym: E-213 TRACHOMA
Synonym: Egyptian Ophthalmia
Synonym: Ophthalmia, Egyptian
Synonym: TRACHOMA
Synonym: Trachoma
Synonym: Trachoma (disorder)
Synonym: Trachoma NOS
Synonym: Trachoma [Disease/Finding]
Synonym: Trachoma, NOS
Synonym: Trachoma, unspecified
Tree Number: T10.7.3.3.6
database_cross_reference: AOD:0000004848
database_cross_reference: CHV:0000012432
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1115-1322
database_cross_reference: DO:DOID:11265
database_cross_reference: DXP:U001901
database_cross_reference: ICD10:A71
database_cross_reference: ICD10:A71.9
database_cross_reference: ICD10AM:A71
database_cross_reference: ICD10AM:A71.9
database_cross_reference: ICD10CM:A71
database_cross_reference: ICD10CM:A71.9
database_cross_reference: ICD9CM:076
database_cross_reference: ICD9CM:076.9
database_cross_reference: ICPC2EENG:F86
database_cross_reference: ICPC2P:F86001
database_cross_reference: LCH:U004739
database_cross_reference: LCH_NW:sh85136427
database_cross_reference: MDR:10044325
database_cross_reference: MDR:10044329
database_cross_reference: MEDCIN:31028
database_cross_reference: MSH:D014141
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:076.9
database_cross_reference: NDFRT:N0000002999
database_cross_reference: RCD:A76..
database_cross_reference: RCD:A76z.
database_cross_reference: RCD:Ayu60
database_cross_reference: RCDSY:Ayu60
database_cross_reference: SNM:D-0335
database_cross_reference: SNMI:DE-21300
database_cross_reference: SNOMEDCT_US:154367007
database_cross_reference: SNOMEDCT_US:186672003
database_cross_reference: SNOMEDCT_US:187379009
database_cross_reference: SNOMEDCT_US:2576002
database_cross_reference: SNOMEDCT_US:266200005

hemorrhagic fever with renal syndrome
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.
PMOID: PMO:00029387
Subclass_of: viral infectious disease
Synonym: Epidemic Hemorrhagic Fever
Synonym: Epidemic Hemorrhagic Fevers
Synonym: Epidemic haemorrhagic fever
Synonym: Epidemic hemorrhagic fever
Synonym: HEMORRHAGIC FEVER WITH RENAL SYNDROME
Synonym: HEMORRHAGIC FEVER, EPIDEMIC
Synonym: HFRS
Synonym: HFRS (hemorrhagic fever with renal syndrome)
Synonym: HFRS - Haem fever & renal synd
Synonym: HFRS - Haemorrhagic fever with renal syndrome
Tree Number: T10.7.2.34
database_cross_reference: CHV:0000006017
database_cross_reference: DO:DOID:0050200
database_cross_reference: DO:DOID:11266
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000803
database_cross_reference: ICD10:A98.5
database_cross_reference: ICD10AM:A98.5
database_cross_reference: ICD10AMAE:A98.5
database_cross_reference: ICD10CM:A98.5
database_cross_reference: ICD9CM:078.6
database_cross_reference: LCH_NW:sh91003558
database_cross_reference: MDR:10019015
database_cross_reference: MDR:10019142
database_cross_reference: MDR:10019606
database_cross_reference: MDR:10023484
database_cross_reference: MDR:10055301
database_cross_reference: MDR:10062539
database_cross_reference: MDR:10075015
database_cross_reference: MDR:10075020
database_cross_reference: MEDCIN:350206
database_cross_reference: MEDCIN:36174
database_cross_reference: MSH:D006480
database_cross_reference: MTHICD9:078.6
database_cross_reference: NCI:C84753
database_cross_reference: NDFRT:N0000001489
database_cross_reference: RCD:A786.
database_cross_reference: RCDAE:A786.
database_cross_reference: SNM:D-0818
database_cross_reference: SNM:D-6735
database_cross_reference: SNMI:DE-34910
database_cross_reference: SNOMEDCT_US:102455002
database_cross_reference: SNOMEDCT_US:186701001
database_cross_reference: SNOMEDCT_US:364756009
database_cross_reference: SNOMEDCT_US:70826003
database_cross_reference: SNOMEDCT_US:716864001

Kyasanur forest disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has material basis in Kyasanur forest disease virus, which is transmitted by Haemaphysalis spinigera tick bite. The infection has symptom fever, has symptom headache, has symptom stiffness of the neck, has symptom severe muscle pain, has symptom cough, has symptom dehydration, and has symptom bleeding problems.
PMOID: PMO:00029399
Subclass_of: viral infectious disease
Synonym: Disease, Kyasanur Forest
Synonym: Forest Disease, Kyasanur
Synonym: KF - Kyasanur Forest disease
Synonym: KFD - Kyasanur Forest disease
Synonym: KYASANUR FOREST DIS
Synonym: Kyasanur Forest Disease
Synonym: Kyasanur Forest Disease [Disease/Finding]
Synonym: Kyasanur Forest disease
Synonym: Kyasanur forest disease (diagnosis)
Synonym: Kyasanur forest disease (disorder)
Tree Number: T10.7.2.43
database_cross_reference: DO:DOID:11320
database_cross_reference: ICD10:A98.2
database_cross_reference: ICD10AM:A98.2
database_cross_reference: ICD10CM:A98.2
database_cross_reference: ICD9CM:065.2
database_cross_reference: MDR:10023505
database_cross_reference: MEDCIN:30850
database_cross_reference: MSH:D007733
database_cross_reference: NDFRT:N0000001767
database_cross_reference: RCD:A652.
database_cross_reference: SNM:D-0420
database_cross_reference: SNMI:DE-33370
database_cross_reference: SNOMEDCT_US:23097003

schizophreniform disorder
type: Class
subclass of: psychotic disorder
definition: A psychotic disorder that involves schizophrenia symptoms over time period of one month.
PMOID: PMO:00028189
Subclass_of: psychotic disorder
Synonym: Disorder, Schizophreniform
Synonym: Disorders, Schizophreniform
Synonym: SCHIZOPHRENIFORM DIS
Synonym: SCHIZOPHRENIFORM DISORDER
Synonym: Schizophreniform Disorder
Synonym: Schizophreniform Disorders
Synonym: Schizophreniform disorder
Synonym: Schizophreniform disorder (disorder)
Synonym: Schizophreniform disorder, NOS
Synonym: Schizophreniform illness
Tree Number: T10.3.12.1.4
database_cross_reference: CCPSS:0037685
database_cross_reference: DO:DOID:11328
database_cross_reference: DSM-5:295.40
database_cross_reference: DSM-5:F20.81
database_cross_reference: ICD10CM:F20.81
database_cross_reference: ICD9CM:295.4
database_cross_reference: MDR:10039647
database_cross_reference: MDR:10039648
database_cross_reference: MEDCIN:32744
database_cross_reference: MSH:D011618
database_cross_reference: NCI:C94376
database_cross_reference: PSY:45447
database_cross_reference: RCD:X00SD
database_cross_reference: SNMI:D9-72020
database_cross_reference: SNOMEDCT_US:88975006

ainhum
type: Class
subclass of: connective tissue disease
definition: A connective tissue disease that results in increasing fibrous constriction and ultimately in spontaneous amputation of the toes and especially the little toes. A painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous amputation (autoamputation) a few years later.
PMOID: PMO:00032298
Subclass_of: connective tissue disease
Synonym: AINHUM
Synonym: Ainhum
Synonym: Ainhum (disorder)
Synonym: Ainhum - dactylolysis spontanea
Synonym: Ainhum [Disease/Finding]
Synonym: Ainhum- dactylolysis spontanea
Synonym: Dactylolyses, Spontaneous
Synonym: Dactylolysis
Synonym: Dactylolysis Spontanea
Synonym: Dactylolysis spontanea
Tree Number: T10.8.4.1.14
database_cross_reference: CHV:0000000835
database_cross_reference: DO:DOID:11329
database_cross_reference: HPO:HP:0031009
database_cross_reference: ICD10:L94.6
database_cross_reference: ICD10AM:L94.6
database_cross_reference: ICD10CM:L94.6
database_cross_reference: ICD9CM:136.0
database_cross_reference: MDR:10001524
database_cross_reference: MEDCIN:97720
database_cross_reference: MSH:D000387
database_cross_reference: MTHICD9:136.0
database_cross_reference: NCI:C84544
database_cross_reference: NDFRT:N0000000345
database_cross_reference: OMIM:103400
database_cross_reference: RCD:AD60.
database_cross_reference: SNM:M-49760
database_cross_reference: SNMI:DE-A0300
database_cross_reference: SNOMEDCT_US:38528001
database_cross_reference: SNOMEDCT_US:51404004

rhinoscleroma
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.
PMOID: PMO:00029519
Subclass_of: primary bacterial infectious disease
Synonym: E-138 RHINOSCLEROMA
Synonym: Infection by Klebsiella rhinoscleromatis
Synonym: Nasal Scleroma
Synonym: Nasal Scleromas
Synonym: RHINOSCLEROMA
Synonym: Rhinoscleroma
Synonym: Rhinoscleroma (disorder)
Synonym: Rhinoscleroma [Disease/Finding]
Synonym: Rhinoscleromas
Synonym: Scleroma
Tree Number: T10.7.3.1.19
database_cross_reference: CHV:0000010856
database_cross_reference: DO:DOID:11336
database_cross_reference: ICD9CM:040.1
database_cross_reference: LCH:U004123
database_cross_reference: LCH_NW:sh85113697
database_cross_reference: MDR:10039102
database_cross_reference: MDR:10063391
database_cross_reference: MEDCIN:31311
database_cross_reference: MSH:D012226
database_cross_reference: NDFRT:N0000002639
database_cross_reference: RCD:A3A1.
database_cross_reference: SNM:D-0172
database_cross_reference: SNMI:DE-13800
database_cross_reference: SNOMEDCT_US:72409005

Lemierre's syndrome
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.
PMOID: PMO:00029603
Subclass_of: commensal bacterial infectious disease
Synonym: E-12A NECROBACILLOSIS
Synonym: Lemierre syndrome
Synonym: NECROBACILLOSIS
Synonym: Necrobacilloses
Synonym: Necrobacillosis
Synonym: Necrobacillosis (disorder)
Synonym: Necrobacillosis, NOS
Synonym: human necrobacillosis
Synonym: necrobacillosis
Synonym: necrobacillosis (diagnosis)
Tree Number: T10.7.3.3.4
database_cross_reference: DO:DOID:11337
database_cross_reference: ICD9CM:040.3
database_cross_reference: MDR:10028846
database_cross_reference: MEDCIN:97400
database_cross_reference: MSH:D005674
database_cross_reference: RCD:A3A3.
database_cross_reference: SNM:D-0152
database_cross_reference: SNMI:DE-12A00
database_cross_reference: SNOMEDCT_US:52542005

tetanus
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has material basis in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.
PMOID: PMO:00029500
Subclass_of: primary bacterial infectious disease
Synonym: E-146 TETANUS
Synonym: Infection caused by Clostridium tetani
Synonym: Infection caused by Clostridium tetani (disorder)
Synonym: Infection due to Clostridium tetani
Synonym: Infection due to Clostridium tetani (disorder)
Synonym: TETANUS
Synonym: Tetanus
Synonym: Tetanus (disorder)
Synonym: Tetanus NOS
Synonym: Tetanus [Disease/Finding]
Tree Number: T10.7.3.1.11
database_cross_reference: AOD:0000004843
database_cross_reference: CHV:0000012123
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0368-2622
database_cross_reference: DO:DOID:11338
database_cross_reference: DXP:U001837
database_cross_reference: ICD10CM:A35
database_cross_reference: ICD9CM:037
database_cross_reference: ICPC2EENG:N72
database_cross_reference: ICPC2P:N72001
database_cross_reference: LCH:U004623
database_cross_reference: LCH_NW:sh85134166
database_cross_reference: MDR:10043376
database_cross_reference: MEDCIN:31029
database_cross_reference: MEDLINEPLUS:435
database_cross_reference: MSH:D013742
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85185
database_cross_reference: NCI_NICHD:C85185
database_cross_reference: NDFRT:N0000002915
database_cross_reference: RCD:A37..
database_cross_reference: SNM:D-0183
database_cross_reference: SNMI:DE-14600
database_cross_reference: SNOMEDCT_US:154312006
database_cross_reference: SNOMEDCT_US:276202003
database_cross_reference: SNOMEDCT_US:76902006

bladder diverticulum
type: Class
subclass of: bladder disease
PMOID: PMO:00033089
Subclass_of: bladder disease
Synonym: BLADDER DIVERTICULUM
Synonym: BLADDER, DIVERTICULUM
Synonym: Bladder Diverticulum
Synonym: Bladder diverticula
Synonym: Bladder diverticulum
Synonym: Diverticulum - bladder
Synonym: Diverticulum of bladder
Synonym: Diverticulum of bladder (disorder)
Synonym: Diverticulum of bladder (disorder) [Ambiguous]
Synonym: Diverticulum of bladder NOS
Tree Number: T10.8.7.11.2
database_cross_reference: CCPSS:0055505
database_cross_reference: CHV:0000017564
database_cross_reference: COSTAR:U000000
database_cross_reference: DO:DOID:11353
database_cross_reference: DXP:U000217
database_cross_reference: HPO:HP:0000015
database_cross_reference: ICD10:N32.3
database_cross_reference: ICD10AM:N32.3
database_cross_reference: ICD10CM:N32.3
database_cross_reference: ICD9CM:596.3
database_cross_reference: MDR:10005038
database_cross_reference: MDR:10013565
database_cross_reference: MEDCIN:34185
database_cross_reference: MSH:C562406
database_cross_reference: OMIM:109820
database_cross_reference: OMIM:MTHU004831
database_cross_reference: RCD:K163.
database_cross_reference: RCD:K163z
database_cross_reference: SNMI:D7-21580
database_cross_reference: SNOMEDCT_US:155888001
database_cross_reference: SNOMEDCT_US:156977001
database_cross_reference: SNOMEDCT_US:197866008
database_cross_reference: SNOMEDCT_US:197869001
database_cross_reference: SNOMEDCT_US:21853005
database_cross_reference: SNOMEDCT_US:252004007
database_cross_reference: SNOMEDCT_US:268335001

bladder calculus
type: Class
subclass of: lower urinary tract calculus
PMOID: PMO:00032980
Subclass_of: lower urinary tract calculus
Synonym: BLADDER CALCULUS
Synonym: BLADDER, CALCULUS
Synonym: Bladder Calculi
Synonym: Bladder Calculi, Urinary
Synonym: Bladder Calculus
Synonym: Bladder Calculus, Urinary
Synonym: Bladder Stone
Synonym: Bladder Stone, Urinary
Synonym: Bladder Stones
Synonym: Bladder Stones, Urinary
Tree Number: T10.8.7.7.1
database_cross_reference: CHV:0000001949
database_cross_reference: CSP:3045-9585
database_cross_reference: CST:BLADDER CALCULUS
database_cross_reference: DO:DOID:11355
database_cross_reference: DXP:U000215
database_cross_reference: DXP:U000374
database_cross_reference: HPO:HP:0010474
database_cross_reference: ICD10:N21.0
database_cross_reference: ICD10AM:N21.0
database_cross_reference: ICD10CM:N21.0
database_cross_reference: ICPC2P:U95001
database_cross_reference: ICPC2P:U95013
database_cross_reference: LCH_NW:sh85014726
database_cross_reference: MDR:10005001
database_cross_reference: MDR:10006987
database_cross_reference: MDR:10007029
database_cross_reference: MDR:10042141
database_cross_reference: MEDCIN:30710
database_cross_reference: MSH:D001744
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:594.1
database_cross_reference: NDFRT:N0000000559
database_cross_reference: RCD:K140.
database_cross_reference: RCD:K140z
database_cross_reference: SNM:M-30000
database_cross_reference: SNM:M-30010
database_cross_reference: SNMI:D7-21810
database_cross_reference: SNOMEDCT_US:155879005
database_cross_reference: SNOMEDCT_US:197830007
database_cross_reference: SNOMEDCT_US:70650003
database_cross_reference: SNOMEDCT_VET:70650003

Phlebotomus fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection, has material basis in Sandfly fever Naples virus, or has material basis in Sandfly fever sicilian virus, which are transmitted by Phlebotomus papatasi sandfly. The infection has symptom fever, has symptom severe frontal headaches, has symptom muscle ache, has symptom joint aches, has symptom flushing of the face, and has symptom tachycardia.
PMOID: PMO:00029396
Subclass_of: viral infectious disease
Synonym: Sandfly fever
Synonym: Sandfly-borne arboviral fever
Synonym: Sandfly-borne bunyavirus fever
Synonym: Sandfly-borne phleboviral disease
Synonym: pappataci fever
Tree Number: T10.7.2.40
database_cross_reference: DO:DOID:11360

gnathomiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis.
PMOID: PMO:00029639
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Gnathostomiasis
Synonym: Infectious Disease by Gnathostoma
Synonym: Wandering swelling
Tree Number: T10.7.4.1.17
database_cross_reference: DO:DOID:11379
database_cross_reference: ICD10CM:B83.1

cryptorchidism
type: Class
subclass of: physical disorder
PMOID: PMO:00028262
Subclass_of: physical disorder
Synonym: CRYPTORCHIDISM
Synonym: CRYPTORCHIDISM, UNILATERAL OR BILATERAL
Synonym: CRYPTORCHISM
Synonym: Cryptorchid
Synonym: Cryptorchidism
Synonym: Cryptorchidism (unilateral or bilateral)
Synonym: Cryptorchidism NOS
Synonym: Cryptorchidism NOS (disorder)
Synonym: Cryptorchidism [Disease/Finding]
Synonym: Cryptorchidism, Unilateral Or Bilateral
Tree Number: T10.4.8
database_cross_reference: CCPSS:0059144
database_cross_reference: CHV:0000003493
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000019
database_cross_reference: CSP:2586-8788
database_cross_reference: CST:ANOMALY CONGEN UG
database_cross_reference: DO:DOID:11383
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000914
database_cross_reference: HPO:HP:0000028
database_cross_reference: ICD10:Q53
database_cross_reference: ICD10:Q53.9
database_cross_reference: ICD10AM:Q53
database_cross_reference: ICD10AM:Q53.9
database_cross_reference: ICD10CM:Q53.9
database_cross_reference: ICD9CM:752.51
database_cross_reference: ICPC2EENG:Y83
database_cross_reference: ICPC2P:Y83001
database_cross_reference: ICPC2P:Y83002
database_cross_reference: LCH:U001215
database_cross_reference: LCH_NW:sh85034467
database_cross_reference: MDR:10011498
database_cross_reference: MDR:10025500
database_cross_reference: MDR:10025501
database_cross_reference: MDR:10043294
database_cross_reference: MDR:10043295
database_cross_reference: MDR:10045505
database_cross_reference: MDR:10045506
database_cross_reference: MDR:10056600
database_cross_reference: MEDCIN:37669
database_cross_reference: MEDCIN:7506
database_cross_reference: MEDLINEPLUS:4280
database_cross_reference: MSH:D003456
database_cross_reference: MTH:U001835
database_cross_reference: MTHICD9:752.51
database_cross_reference: NCI:C12326
database_cross_reference: NCI_NCI-GLOSS:CDR0000044388
database_cross_reference: NCI_NCI-GLOSS:CDR0000046458
database_cross_reference: NCI_NICHD:C12326
database_cross_reference: NDFRT:N0000000881
database_cross_reference: OMIM:146738
database_cross_reference: OMIM:219050
database_cross_reference: OMIM:MTHU000066
database_cross_reference: OMIM:MTHU001426
database_cross_reference: OMIM:MTHU017447
database_cross_reference: OMIM:MTHU048866
database_cross_reference: OMIM:MTHU051395
database_cross_reference: RCD:PC5..
database_cross_reference: RCD:PC50.
database_cross_reference: RCD:PC50z
database_cross_reference: RCD:XE1LF
database_cross_reference: SNM:M-26200
database_cross_reference: SNMI:D4-85110
database_cross_reference: SNOMEDCT_US:156967003
database_cross_reference: SNOMEDCT_US:204878001
database_cross_reference: SNOMEDCT_US:204879009
database_cross_reference: SNOMEDCT_US:204882004
database_cross_reference: SNOMEDCT_US:268226005
database_cross_reference: SNOMEDCT_US:367721002
database_cross_reference: SNOMEDCT_US:37501009
database_cross_reference: SNOMEDCT_VET:204878001

epidural abscess
type: Class
subclass of: central nervous system disease
definition: A central nervous system disease that is characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine and is caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges).
PMOID: PMO:00030707
Subclass_of: central nervous system disease
Synonym: Abscess, Epidural
Synonym: Abscess, Extradural
Synonym: EPIDURAL ABSCESS
Synonym: Epidural Abscess
Synonym: Epidural Abscess [Disease/Finding]
Synonym: Epidural abscess
Synonym: Epidural abscess (disorder)
Synonym: Extradural Abscess
Synonym: Extradural abscess
Synonym: Extradural abscess NOS
Tree Number: T10.8.2.9.11
database_cross_reference: CCPSS:0031155
database_cross_reference: CHV:0000026490
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:11387
database_cross_reference: MDR:10015010
database_cross_reference: MDR:10015768
database_cross_reference: MDR:10061846
database_cross_reference: MSH:D020802
database_cross_reference: NDFRT:N0000004192
database_cross_reference: RCD:XaCMf
database_cross_reference: SNMI:DA-10405
database_cross_reference: SNOMEDCT_US:192752004
database_cross_reference: SNOMEDCT_US:310671007
database_cross_reference: SNOMEDCT_US:61974008

subdural empyema
type: Class
subclass of: central nervous system disease
PMOID: PMO:00030240
Subclass_of: central nervous system disease
Synonym: ABSCESS, SUBDURAL
Synonym: EMPYEMA, SUBDURAL, INTRACRANIAL
Synonym: Empyema (collection of pus), subdural space
Synonym: Empyema, Subdural
Synonym: Empyema, Subdural [Disease/Finding]
Synonym: Empyema, subdural
Synonym: PACHYMENINGITIS, SUBDURAL
Synonym: Subdural Abscess
Synonym: Subdural Empyema
Synonym: Subdural Empyemas
Tree Number: T10.8.2.9.2
database_cross_reference: CHV:0000011811
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:11389
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000527
database_cross_reference: MDR:10042360
database_cross_reference: MEDCIN:30885
database_cross_reference: MSH:D013354
database_cross_reference: NDFRT:N0000002850
database_cross_reference: SNM:M-41400
database_cross_reference: SNMI:DA-10406
database_cross_reference: SNOMEDCT_US:37660004

heart disease
type: Class
subclass of: cardiovascular system disease
definition: A cardiovascular system disease that involves the heart.
PMOID: PMO:00031608
Subclass_of: cardiovascular system disease
Synonym: 3-10 HEART DISEASES: GENERAL TERMS
Synonym: CARDIAC DIS
Synonym: Card
Synonym: Cardiac Disease
Synonym: Cardiac Diseases
Synonym: Cardiac Disorders
Synonym: Cardiac diseases
Synonym: Cardiac disorder
Synonym: Cardiac disorder NOS
Synonym: Cardiac disorders
Tree Number: T10.8.3.2
database_cross_reference: AOD:0000005338
database_cross_reference: AOD:0000023339
database_cross_reference: AOD:0000023340
database_cross_reference: AOD:0000023341
database_cross_reference: CCPSS:0046242
database_cross_reference: CHV:0000005875
database_cross_reference: COSTAR:U000028
database_cross_reference: CSP:1393-3247
database_cross_reference: CST:CARDIOVASC DIS
database_cross_reference: CST:CV/CARD
database_cross_reference: DO:DOID:114
database_cross_reference: ICD10:I51.9
database_cross_reference: ICD10AM:I51.9
database_cross_reference: ICD10CM:I51.9
database_cross_reference: ICD9CM:429.9
database_cross_reference: ICPC2P:K84009
database_cross_reference: LCH_NW:sh85059651
database_cross_reference: LNC:LA10523-1
database_cross_reference: MDR:10007540
database_cross_reference: MDR:10007541
database_cross_reference: MDR:10013199
database_cross_reference: MDR:10019276
database_cross_reference: MDR:10019277
database_cross_reference: MDR:10061024
database_cross_reference: MEDCIN:314306
database_cross_reference: MEDCIN:33161
database_cross_reference: MEDLINEPLUS:277
database_cross_reference: MSH:D006331
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:429.9
database_cross_reference: NCI:C3079
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NICHD:C3079
database_cross_reference: NDFRT:N0000001432
database_cross_reference: PSY:07600
database_cross_reference: PSY:22480
database_cross_reference: RCD:G5z..
database_cross_reference: RCD:X2003
database_cross_reference: SNM:D-7030
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D3-10000
database_cross_reference: SNOMEDCT_US:155263000
database_cross_reference: SNOMEDCT_US:194707003
database_cross_reference: SNOMEDCT_US:195152001
database_cross_reference: SNOMEDCT_US:266275004
database_cross_reference: SNOMEDCT_US:266311004
database_cross_reference: SNOMEDCT_US:56265001

diphtheria
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.
PMOID: PMO:00029588
Subclass_of: primary bacterial infectious disease
Synonym: CORYNEBACT INFECT
Synonym: Corynebacteria infections
Synonym: Corynebacteriosis
Synonym: Corynebacterium Infection
Synonym: Corynebacterium Infections
Synonym: Corynebacterium Infections [Disease/Finding]
Synonym: Corynebacterium infection
Synonym: Corynebacterium infection NOS
Synonym: INFECT CORYNEBACT
Synonym: Infection caused by Corynebacterium
Tree Number: T10.7.3.1.40
database_cross_reference: DO:DOID:11405
database_cross_reference: MDR:10011210
database_cross_reference: MDR:10011212
database_cross_reference: MDR:10061092
database_cross_reference: MSH:D003354
database_cross_reference: NDFRT:N0000000862
database_cross_reference: SNOMEDCT_US:397434007
database_cross_reference: SNOMEDCT_VET:397434007

autonomic nervous system disease
type: Class
subclass of: peripheral nervous system disease
PMOID: PMO:00029896
Subclass_of: peripheral nervous system disease
Synonym: Aut neuropthy in oth dis
Synonym: Peripheral autonomic neuropathy in disorders classified elsewhere
Synonym: autonomic nervous system disorder
Tree Number: T10.8.2.4.4
database_cross_reference: DO:DOID:11465
database_cross_reference: ICD9CM:337.1
database_cross_reference: MDR:10034566

polydactyly
type: Class
subclass of: physical disorder
PMOID: PMO:00028267
Subclass_of: physical disorder
Synonym: Accessory digit
Synonym: Hyperdactylies
Synonym: Hyperdactyly
Synonym: Multiple digits
Synonym: POLYDACTYLY
Synonym: Polydactylia
Synonym: Polydactylias
Synonym: Polydactylies
Synonym: Polydactylism
Synonym: Polydactylisms
Tree Number: T10.4.13
database_cross_reference: AOD:0000004995
database_cross_reference: CCPSS:0044276
database_cross_reference: CHV:0000017272
database_cross_reference: CST:ANOMALY CONGEN MS
database_cross_reference: DO:DOID:1148
database_cross_reference: DXP:U003192
database_cross_reference: HPO:HP:0010442
database_cross_reference: ICD10:Q69
database_cross_reference: ICD10:Q69.9
database_cross_reference: ICD10AM:Q69
database_cross_reference: ICD10AM:Q69.9
database_cross_reference: ICD10CM:Q69
database_cross_reference: ICD10CM:Q69.9
database_cross_reference: ICD9CM:755.0
database_cross_reference: ICD9CM:755.00
database_cross_reference: ICPC2P:L82030
database_cross_reference: MDR:10028188
database_cross_reference: MDR:10036063
database_cross_reference: MDR:10036066
database_cross_reference: MEDCIN:330511
database_cross_reference: MSH:D017689
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:755.00
database_cross_reference: NCI:C87110
database_cross_reference: NCI_NICHD:C87110
database_cross_reference: NDFRT:N0000003623
database_cross_reference: OMIM:603596
database_cross_reference: OMIM:MTHU007674
database_cross_reference: OMIM:MTHU026393
database_cross_reference: RCD:PF0..
database_cross_reference: RCD:PF00.
database_cross_reference: RCD:PF0z.
database_cross_reference: SNM:M-22300
database_cross_reference: SNMI:D4-12200
database_cross_reference: SNOMEDCT_US:156988007
database_cross_reference: SNOMEDCT_US:205119005
database_cross_reference: SNOMEDCT_US:205120004
database_cross_reference: SNOMEDCT_US:205136002
database_cross_reference: SNOMEDCT_US:367506006
database_cross_reference: SNOMEDCT_US:403562000
database_cross_reference: SNOMEDCT_US:74537000

hypertensive heart disease
type: Class
subclass of: heart disease
definition: A heart disease that is caused by high blood pressure.
PMOID: PMO:00031771
Subclass_of: heart disease
Synonym: HHD - Hypertensive heart dis
Synonym: HHD - Hypertensive heart disease
Synonym: HYPERTENSIVE CARDIOVASCULAR DISEASE
Synonym: HYPERTENSIVE HEART DISEASE
Synonym: Hypertension;heart disease
Synonym: Hypertensive cardiopathy
Synonym: Hypertensive cardiovascular disease
Synonym: Hypertensive heart disease
Synonym: Hypertensive heart disease (disorder)
Synonym: Hypertensive heart disease NOS
Tree Number: T10.8.3.2.6
database_cross_reference: CCPSS:0056605
database_cross_reference: CHV:0000017172
database_cross_reference: CHV:0000049689
database_cross_reference: COSTAR:U000349
database_cross_reference: DO:DOID:11516
database_cross_reference: ICD10:I11
database_cross_reference: ICD10AM:I11
database_cross_reference: ICD10CM:I11
database_cross_reference: ICD10CM:I11.9
database_cross_reference: ICD9CM:402
database_cross_reference: ICD9CM:402.9
database_cross_reference: ICPC2P:K87001
database_cross_reference: MDR:10020823
database_cross_reference: MDR:10020824
database_cross_reference: MDR:10020827
database_cross_reference: MDR:10045916
database_cross_reference: MEDCIN:34081
database_cross_reference: RCD:G21..
database_cross_reference: RCD:G21z.
database_cross_reference: SNM:D-7371
database_cross_reference: SNMI:D3-02500
database_cross_reference: SNOMEDCT_US:155297007
database_cross_reference: SNOMEDCT_US:194769003
database_cross_reference: SNOMEDCT_US:194772005
database_cross_reference: SNOMEDCT_US:64715009

Adie syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon.
PMOID: PMO:00025124
Subclass_of: syndrome
Synonym: ADIE SYNDROME
Synonym: Adie Pupil
Synonym: Adie Syndrome
Synonym: Adie Syndrome [Disease/Finding]
Synonym: Adie's Syndrome
Synonym: Adie's pupil
Synonym: Adie's pupil (disorder)
Synonym: Adie's pupil or syndrome
Synonym: Adie's pupil syndrome
Synonym: Adie's syndrome
Tree Number: T10.1.9
database_cross_reference: CHV:0000000738
database_cross_reference: DO:DOID:11549
database_cross_reference: MDR:10020353
database_cross_reference: MSH:D000270
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:379.46
database_cross_reference: NCI:C34357
database_cross_reference: NDFRT:N0000000317
database_cross_reference: OMIM:103100
database_cross_reference: RCD:F4K46
database_cross_reference: SNM:D-8423
database_cross_reference: SNMI:DA-72817
database_cross_reference: SNOMEDCT_US:123051004
database_cross_reference: SNOMEDCT_US:24225004

neurocirculatory asthenia
type: Class
subclass of: somatoform disorder
definition: A heart conduction disease characterized by orthostatic intolerance that has_material_basis_in heterozygous mutation in the SLC6A2 gene on chromosome 16q12.2.
PMOID: PMO:00028127
Subclass_of: somatoform disorder
Synonym: Asthenia, Neurocirculatory
Synonym: Asthenias, Neurocirculatory
Synonym: CARDIAC NEUROSIS
Synonym: Cardiac Neuroses
Synonym: Cardiac Neurosis
Synonym: Cardiac neurosis
Synonym: Cardiac neurosis (disorder)
Synonym: Cardioneurosis
Synonym: Cardiovascular disorder, psychogenic
Synonym: Cardiovascular malfunction arising from mental factors
Tree Number: T10.3.6.2
database_cross_reference: AOD:0000006716
database_cross_reference: AOD:0000006719
database_cross_reference: CHV:0000008630
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:NEUROSIS
database_cross_reference: DO:DOID:0111154
database_cross_reference: DO:DOID:11569
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001282
database_cross_reference: ICD9CM:306.2
database_cross_reference: ICPC2P:P75002
database_cross_reference: MDR:10007592
database_cross_reference: MDR:10007655
database_cross_reference: MDR:10014293
database_cross_reference: MDR:10029262
database_cross_reference: MDR:10029334
database_cross_reference: MDR:10042803
database_cross_reference: MDR:10058076
database_cross_reference: MEDCIN:35996
database_cross_reference: MSH:D009449
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:306.2
database_cross_reference: NDFRT:N0000002168
database_cross_reference: OMIM:604715
database_cross_reference: RCD:E262.
database_cross_reference: RCD:E2622
database_cross_reference: SNM:D-7063
database_cross_reference: SNM:D-9245
database_cross_reference: SNMI:D3-10610
database_cross_reference: SNMI:D9-86100
database_cross_reference: SNOMEDCT_US:154922007
database_cross_reference: SNOMEDCT_US:191960008
database_cross_reference: SNOMEDCT_US:191961007
database_cross_reference: SNOMEDCT_US:191962000
database_cross_reference: SNOMEDCT_US:191963005
database_cross_reference: SNOMEDCT_US:192434000
database_cross_reference: SNOMEDCT_US:46219009
database_cross_reference: SNOMEDCT_US:72994002

listeriosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.
PMOID: PMO:00029587
Subclass_of: primary bacterial infectious disease
Synonym: Circling disease
Synonym: E-125 LISTERIOSIS
Synonym: INFECT LISTERIA
Synonym: Infection by Listeria monocytogenes
Synonym: Infection caused by Listeria
Synonym: Infection caused by Listeria (disorder)
Synonym: Infection due to Listeria monocytogenes
Synonym: Infection due to Listeria monocytogenes (disorder)
Synonym: Infection, Listeria
Synonym: Infections, Listeria
Tree Number: T10.7.3.1.39
database_cross_reference: CHV:0000007484
database_cross_reference: CSP:0368-3200
database_cross_reference: DO:DOID:11573
database_cross_reference: DXP:U001067
database_cross_reference: ICD10:A32
database_cross_reference: ICD10:A32.9
database_cross_reference: ICD10AM:A32
database_cross_reference: ICD10AM:A32.9
database_cross_reference: ICD10CM:A32
database_cross_reference: ICD10CM:A32.9
database_cross_reference: ICD9CM:027.0
database_cross_reference: LCH_NW:sh85077461
database_cross_reference: LNC:LA10485-3
database_cross_reference: MDR:10024638
database_cross_reference: MDR:10024639
database_cross_reference: MDR:10024640
database_cross_reference: MDR:10024641
database_cross_reference: MEDCIN:31085
database_cross_reference: MEDCIN:31200
database_cross_reference: MEDLINEPLUS:1241
database_cross_reference: MSH:D008088
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:027.0
database_cross_reference: NCI:C82994
database_cross_reference: NDFRT:N0000001859
database_cross_reference: RCD:A270.
database_cross_reference: RCD:A270z
database_cross_reference: RCD:Ayu35
database_cross_reference: RCDSY:Ayu35
database_cross_reference: SNM:D-0137
database_cross_reference: SNMI:DE-12500
database_cross_reference: SNOMEDCT_US:186315001
database_cross_reference: SNOMEDCT_US:186320001
database_cross_reference: SNOMEDCT_US:187320005
database_cross_reference: SNOMEDCT_US:406591006
database_cross_reference: SNOMEDCT_US:4241002
database_cross_reference: SNOMEDCT_US:721739005

Cauda equina syndrome
type: Class
subclass of: peripheral nervous system disease
definition: A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.
PMOID: PMO:00030152
Subclass_of: peripheral nervous system disease
Synonym: CAUDA EQUINA SYNDROME
Synonym: Cauda Equina Syndrome
Synonym: Cauda Equina Syndromes
Synonym: Cauda equina neuritis
Synonym: Cauda equina syndrome (disorder)
Synonym: Cauda equina syndrome (disorder) [Ambiguous]
Synonym: Cauda equina syndrome NOS
Synonym: Cauda equina syndrome NOS (disorder)
Synonym: Cauda equina syndrome, NOS
Synonym: Lumbosacral syndrome
Tree Number: T10.8.2.4.6
database_cross_reference: CCPSS:0060393
database_cross_reference: CHV:0000032112
database_cross_reference: DO:DOID:11577
database_cross_reference: DXP:U000305
database_cross_reference: DXP:U000574
database_cross_reference: ICD10:G83.4
database_cross_reference: ICD10AM:G83.4
database_cross_reference: ICD10CM:G83.4
database_cross_reference: ICD9CM:344.6
database_cross_reference: ICPC2P:N99026
database_cross_reference: MDR:10007821
database_cross_reference: MDR:10057324
database_cross_reference: MEDCIN:32264
database_cross_reference: MSH:D011128
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35436
database_cross_reference: OMIM:MTHU038829
database_cross_reference: RCD:F246.
database_cross_reference: RCD:F246z
database_cross_reference: SNM:D-8X18
database_cross_reference: SNMI:DA-26160
database_cross_reference: SNOMEDCT_US:155032006
database_cross_reference: SNOMEDCT_US:192970008
database_cross_reference: SNOMEDCT_US:192972000
database_cross_reference: SNOMEDCT_US:192973005
database_cross_reference: SNOMEDCT_US:89356000
database_cross_reference: SNOMEDCT_VET:192970008

functional gastric disease
type: Class
subclass of: stomach disease
PMOID: PMO:00033455
Subclass_of: stomach disease
Synonym: Dyspepsia and other specified disorders of function of stomach
Synonym: Stomach function dis NEC
Tree Number: T10.8.11.3.4
database_cross_reference: DO:DOID:1159
database_cross_reference: ICD9CM:536.8
database_cross_reference: MDR:10013948

infant gynecomastia
type: Class
subclass of: breast disease
definition: A breast disease that is characterized by benign proliferation of glandular breast tissue and occurs in children less than one year of age.
PMOID: PMO:00033249
Subclass_of: breast disease
Synonym: Breast Engorgement in Newborn
Synonym: Breast engorgement in newborn
Synonym: Breast engorgement in newborn (disorder)
Synonym: Breast engorgement of new born
Synonym: Breast engorgement of newborn
Synonym: Gynecomastia, Infant
Synonym: Gynecomastia, Newborn
Synonym: Infant Gynecomastia
Synonym: NB breast engorgement
Synonym: NEONATAL BREAST ENGORGEMENT
Tree Number: T10.8.9.1.2
database_cross_reference: COSTAR:U000444
database_cross_reference: DO:DOID:11603
database_cross_reference: ICD10:P83.4
database_cross_reference: ICD10AM:P83.4
database_cross_reference: ICD10CM:P83.4
database_cross_reference: ICD9CM:778.7
database_cross_reference: MDR:10006241
database_cross_reference: MSH:D006177
database_cross_reference: NCI:C117312
database_cross_reference: NCI_NICHD:C117312
database_cross_reference: RCD:Q477.
database_cross_reference: RCDAE:Q477.
database_cross_reference: SNMI:D8-77330
database_cross_reference: SNOMEDCT_US:157159001
database_cross_reference: SNOMEDCT_US:34831003

polycystic ovary syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.
PMOID: PMO:00025178
Subclass_of: syndrome
Synonym: (Polycystic ovaries) or (Stein-Leventhal syndrome)
Synonym: (Polycystic ovaries) or (Stein-Leventhal syndrome) (disorder)
Synonym: BILATERAL POLYCYSTIC OVARIAN SYNDROME
Synonym: Cystic disease of ovaries
Synonym: Cystic disease of ovary
Synonym: HYPERTHECOSIS, OVARIAN
Synonym: Multicystic ovaries
Synonym: Multicystic ovaries (disorder)
Synonym: OVARIAN POLYCYSTIC DISEASE
Synonym: Ovarian Degeneration, Sclerocystic
Tree Number: T10.1.59
database_cross_reference: BI:BI00395
database_cross_reference: CCPSS:0023791
database_cross_reference: CHV:0000009909
database_cross_reference: COSTAR:702
database_cross_reference: CSP:2587-6111
database_cross_reference: CSP:2587-6155
database_cross_reference: DO:DOID:11612
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001781
database_cross_reference: HPO:HP:0000147
database_cross_reference: ICD10:E28.2
database_cross_reference: ICD10AM:E28.2
database_cross_reference: ICD10CM:E28.2
database_cross_reference: ICD9CM:256.4
database_cross_reference: ICPC2P:T99040
database_cross_reference: ICPC2P:T99043
database_cross_reference: LCH_NW:sh85127892
database_cross_reference: MDR:10036049
database_cross_reference: MDR:10036050
database_cross_reference: MDR:10041971
database_cross_reference: MDR:10065161
database_cross_reference: MEDCIN:30469
database_cross_reference: MEDLINEPLUS:5912
database_cross_reference: MSH:D011085
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:256.4
database_cross_reference: NCI:C26862
database_cross_reference: NCI_NCI-GLOSS:CDR0000454780
database_cross_reference: NCI_NCI-GLOSS:CDR0000454781
database_cross_reference: NDFRT:N0000002452
database_cross_reference: OMIM:184700
database_cross_reference: OMIM:MTHU002076
database_cross_reference: OMIM:MTHU014687
database_cross_reference: OMIM:MTHU033655
database_cross_reference: OMIM:MTHU048896
database_cross_reference: OMIM:MTHU053019
database_cross_reference: RCD:X406n
database_cross_reference: RCD:X40NO
database_cross_reference: RCD:XE10l
database_cross_reference: SNM:D-2601
database_cross_reference: SNM:M-33830
database_cross_reference: SNM:M-74300
database_cross_reference: SNMI:DB-21500
database_cross_reference: SNOMEDCT_US:154714009
database_cross_reference: SNOMEDCT_US:190549002
database_cross_reference: SNOMEDCT_US:237055002
database_cross_reference: SNOMEDCT_US:237792009
database_cross_reference: SNOMEDCT_US:271199009
database_cross_reference: SNOMEDCT_US:69878008

palindromic rheumatism
type: Class
subclass of: syndrome
PMOID: PMO:00025175
Subclass_of: syndrome
Synonym: HYDRARTHROSIS, INTERMITTENT
Synonym: Intermittent effusion of joint
Synonym: Intermittent effusion of joint (disorder)
Synonym: Intermittent hydrarthrosis
Synonym: Intermittent joint effusion
Synonym: Intermittent joint effusion (disorder)
Synonym: intermittent hydrarthrosis
Synonym: palindromic rheumatism (diagnosis)
Tree Number: T10.1.56
database_cross_reference: DXP:U000861
database_cross_reference: ICD10:M12.4
database_cross_reference: ICD10AM:M12.4
database_cross_reference: ICD10CM:M12.4
database_cross_reference: MEDCIN:32615
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:719.3
database_cross_reference: RCD:X701A
database_cross_reference: SNMI:D1-22550
database_cross_reference: SNOMEDCT_US:202390005
database_cross_reference: SNOMEDCT_US:202455001
database_cross_reference: SNOMEDCT_US:239772005
database_cross_reference: SNOMEDCT_US:50442003
database_cross_reference: SNOMEDCT_US:711286009

Patau syndrome
type: Class
subclass of: chromosomal disease
PMOID: PMO:00028758
Subclass_of: chromosomal disease
Synonym: 13 trisomies
Synonym: 13 trisomy
Synonym: Bartholin-Patau syndrome
Synonym: Chromosomal imbalance syndrome, pair 13, trisomy
Synonym: Chromosome 13 trisomy
Synonym: Chromosome 13 trisomy syndrome
Synonym: Complete Trisomy 13 Syndrome
Synonym: Complete trisomy 13 syndrome
Synonym: Complete trisomy 13 syndrome (disorder)
Synonym: D1 Trisomy
Tree Number: T10.5.9.3
database_cross_reference: CHV:0000017165
database_cross_reference: DO:DOID:11665
database_cross_reference: ICD10:Q91.7
database_cross_reference: ICD10AM:Q91.7
database_cross_reference: ICD10CM:Q91.7
database_cross_reference: ICD9CM:758.1
database_cross_reference: JABL:169
database_cross_reference: LNC:LP187147-6
database_cross_reference: LNC:MTHU048468
database_cross_reference: MDR:10034115
database_cross_reference: MDR:10044686
database_cross_reference: MEDCIN:30419
database_cross_reference: MSH:C536305
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:758.1
database_cross_reference: NCI:C101223
database_cross_reference: NCI_NICHD:C101223
database_cross_reference: RCD:PJ1..
database_cross_reference: RCD:X78Eo
database_cross_reference: SNM:D-5632
database_cross_reference: SNMI:D4-02134
database_cross_reference: SNOMEDCT_US:156995003
database_cross_reference: SNOMEDCT_US:157021007
database_cross_reference: SNOMEDCT_US:205622008
database_cross_reference: SNOMEDCT_US:21111006
database_cross_reference: SNOMEDCT_US:254267009
database_cross_reference: SNOMEDCT_US:268344000
database_cross_reference: SNOMEDCT_US:268357008

familial hyperlipidemia
type: Class
subclass of: lipid metabolism disorder
PMOID: PMO:00029260
Subclass_of: lipid metabolism disorder
Synonym: Disorder characterized by hyperlipidemia
Synonym: HLD - Hyperlipidaemia
Synonym: HLD - Hyperlipidemia
Synonym: HYPERLIPAEMIA
Synonym: HYPERLIPEMIA
Synonym: HYPERLIPIDEMIA
Synonym: Hyperlipaemia
Synonym: Hyperlipemia
Synonym: Hyperlipemias
Synonym: Hyperlipidaemia
Tree Number: T10.6.2.18.7
database_cross_reference: AOD:0000005732
database_cross_reference: BI:BI00109
database_cross_reference: CCPSS:1006712
database_cross_reference: CHV:0000006419
database_cross_reference: COSTAR:395
database_cross_reference: CSP:1744-2444
database_cross_reference: CST:HYPERLIPEM
database_cross_reference: DO:DOID:1168
database_cross_reference: DXP:U002027
database_cross_reference: HPO:HP:0003077
database_cross_reference: ICD10:E78.5
database_cross_reference: ICD10AM:E78.5
database_cross_reference: ICD10AMAE:E78.5
database_cross_reference: ICD10CM:E78.5
database_cross_reference: ICPC2P:T93008
database_cross_reference: LCH:U002308
database_cross_reference: LCH_NW:sh85063704
database_cross_reference: MDR:10020661
database_cross_reference: MDR:10020662
database_cross_reference: MDR:10020663
database_cross_reference: MDR:10020667
database_cross_reference: MDR:10062060
database_cross_reference: MEDLINEPLUS:26
database_cross_reference: MEDLINEPLUS:4277
database_cross_reference: MSH:D006949
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:272.4
database_cross_reference: NCI:C34707
database_cross_reference: NDFRT:N0000001592
database_cross_reference: OMIM:MTHU002043
database_cross_reference: RCD:C324.
database_cross_reference: RCD:X40Wy
database_cross_reference: RCDAE:C324.
database_cross_reference: RCDAE:X40Wy
database_cross_reference: SNMI:D6-60010
database_cross_reference: SNOMEDCT_US:154739000
database_cross_reference: SNOMEDCT_US:154743001
database_cross_reference: SNOMEDCT_US:190782002
database_cross_reference: SNOMEDCT_US:267499005
database_cross_reference: SNOMEDCT_US:55822004
database_cross_reference: SNOMEDCT_VET:55822004

impaired renal function disease
type: Class
subclass of: kidney disease
PMOID: PMO:00033042
Subclass_of: kidney disease
Synonym: Impair ren funct dis NEC
Synonym: Other specified disorders resulting from impaired renal function
Tree Number: T10.8.7.9.16
database_cross_reference: DO:DOID:11705
database_cross_reference: ICD9CM:588.8
database_cross_reference: ICD9CM:588.89
database_cross_reference: MDR:10032704

antidepressant type abuse
type: Class
subclass of: substance abuse
definition: A substance abuse that involves the recurring use of antidepressant drugs despite negative consequences.
PMOID: PMO:00027913
Subclass_of: substance abuse
Synonym: Antidepressant type abuse
Tree Number: T10.3.3.2.1
database_cross_reference: DO:DOID:11718
database_cross_reference: ICD9CM:305.8
database_cross_reference: MDR:10002768

Cornelia de Lange syndrome
type: Class
subclass of: genetic disease
definition: A genetic disease that is characterized by slow growth before and after birth, intellectual disability that is usually severe to profound, skeletal abnormalities involving the arms and hands, and distinctive facial features.
PMOID: PMO:00028739
Subclass_of: genetic disease
Synonym: Amstelodamensis, Typus Degenerativus
Synonym: Amsterdam dwarf
Synonym: Amsterdam type
Synonym: BDLS
Synonym: BRACHMANN-DE LANGE SYNDROME
Synonym: Brachmann De Lange Syndrome
Synonym: Brachmann de Lange syndrome
Synonym: Brachmann-Cornelia de Lange (BCDL) syndrome (BDLS)
Synonym: Brachmann-Cornelia de Lange syndrome
Synonym: Brachmann-De Lange Syndrome
Tree Number: T10.5.4
database_cross_reference: CHV:0000026562
database_cross_reference: CSP:0944-7801
database_cross_reference: CSP:1354-8678
database_cross_reference: CSP:2403-8925
database_cross_reference: DO:DOID:11725
database_cross_reference: DRUGBANK:DB03429
database_cross_reference: ICD10CM:Q87.1
database_cross_reference: JABL:260
database_cross_reference: LCH:U001276
database_cross_reference: LCH_NW:sh85036011
database_cross_reference: MDR:10056354
database_cross_reference: MDR:10077707
database_cross_reference: MEDCIN:36129
database_cross_reference: MSH:D003635
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75016
database_cross_reference: NCI_NICHD:C75016
database_cross_reference: NDFRT:N0000000900
database_cross_reference: OMIM:122470
database_cross_reference: OMIM:608667
database_cross_reference: RCD:PKy60
database_cross_reference: SNM:D-5012
database_cross_reference: SNM:M-70150
database_cross_reference: SNMI:D4-00211
database_cross_reference: SNOMEDCT_US:40354009

Lyme disease
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.
PMOID: PMO:00029503
Subclass_of: primary bacterial infectious disease
Synonym: Bannwarth syndrome
Synonym: Bannworth's syndrome
Synonym: Borrelia
Synonym: Borrelia burgdorferi Infection
Synonym: Borrelia burgdorferi infection
Synonym: Borreliosis, Lyme
Synonym: Disease, Lyme
Synonym: Disease;lyme
Synonym: Infection by Borrelia burgdorferi
Synonym: Infection due to Borrelia burgdorferi sensu lato
Tree Number: T10.7.3.1.13
database_cross_reference: CCPSS:0046878
database_cross_reference: CHV:0000007589
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0368-3340
database_cross_reference: DO:DOID:11729
database_cross_reference: DXP:U001109
database_cross_reference: ICD10:A69.2
database_cross_reference: ICD10AM:A69.2
database_cross_reference: ICD10CM:A69.2
database_cross_reference: ICD10CM:A69.20
database_cross_reference: ICD9CM:088.81
database_cross_reference: ICPC2P:A78039
database_cross_reference: LCH_NW:sh87003150
database_cross_reference: LNC:LA10487-9
database_cross_reference: MDR:10006036
database_cross_reference: MDR:10025169
database_cross_reference: MDR:10025170
database_cross_reference: MDR:10025171
database_cross_reference: MDR:10067559
database_cross_reference: MEDCIN:33757
database_cross_reference: MEDLINEPLUS:84
database_cross_reference: MSH:D008193
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000179
database_cross_reference: NCI:C45161
database_cross_reference: NCI_NICHD:C45161
database_cross_reference: NDFRT:N0000001890
database_cross_reference: RCD:A8710
database_cross_reference: SNM:D-0823
database_cross_reference: SNMI:DE-13741
database_cross_reference: SNOMEDCT_US:154376000
database_cross_reference: SNOMEDCT_US:23502006

choledocholithiasis
type: Class
subclass of: gallbladder disease
PMOID: PMO:00033492
Subclass_of: gallbladder disease
Synonym: Bile duct calculus
Synonym: CHOLEDOCHOLITHIASIS
Synonym: Choledocholithiasis
Synonym: Choledocholithiasis [Disease/Finding]
Synonym: Cholelithiasis, Common Bile Duct
Synonym: choledocholithiasis (diagnosis)
Tree Number: T10.8.11.10.4
database_cross_reference: AOD:0000005680
database_cross_reference: BI:BI00219
database_cross_reference: CCPSS:0032513
database_cross_reference: CHV:0000045026
database_cross_reference: COSTAR:U000132
database_cross_reference: CSP:0413-4335
database_cross_reference: DO:DOID:11755
database_cross_reference: DXP:U000336
database_cross_reference: MDR:10049891
database_cross_reference: MEDCIN:30049
database_cross_reference: MEDLINEPLUS:4643
database_cross_reference: MSH:D042883
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000010954
database_cross_reference: RCD:X308J
database_cross_reference: SNM:M-30010
database_cross_reference: SNMI:D5-85610
database_cross_reference: SNOMEDCT_US:197376000
database_cross_reference: SNOMEDCT_US:197397004
database_cross_reference: SNOMEDCT_US:49910001

hypochromic anemia
type: Class
subclass of: anemia
PMOID: PMO:00033326
Subclass_of: anemia
Synonym: ANAEMIA HYPOCHROMIC
Synonym: ANEMIA HYPOCHROMIC
Synonym: Anaemia hypochromic
Synonym: Anemia hypochromic
Synonym: Anemia, Hypochromic
Synonym: Anemia, Hypochromic [Disease/Finding]
Synonym: Anemias, Hypochromic
Synonym: HYPOCHROMIC ANEMIA
Synonym: Hypochromic Anemia
Synonym: Hypochromic Anemias
Tree Number: T10.8.10.4.1
database_cross_reference: CCPSS:0048710
database_cross_reference: CHV:0000001127
database_cross_reference: CHV:0000026681
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0427-2389
database_cross_reference: CST:ANEMIA HYPOCHROM
database_cross_reference: DO:DOID:11759
database_cross_reference: HPO:HP:0001931
database_cross_reference: ICD10CM:D50
database_cross_reference: LCH_NW:sh85063766
database_cross_reference: MDR:10002060
database_cross_reference: MDR:10002293
database_cross_reference: MDR:10020969
database_cross_reference: MDR:10020971
database_cross_reference: MSH:D000747
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34380
database_cross_reference: NDFRT:N0000000391
database_cross_reference: OMIM:MTHU006440
database_cross_reference: SNMI:DC-10022
database_cross_reference: SNOMEDCT_US:44452003

bronchial disease
type: Class
subclass of: lower respiratory tract disease
definition: A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage.
PMOID: PMO:00032584
Subclass_of: lower respiratory tract disease
Synonym: BRONCHIAL DIS
Synonym: Bronchi--Diseases
Synonym: Bronchial Disease
Synonym: Bronchial Diseases
Synonym: Bronchial Diseases [Disease/Finding]
Synonym: Bronchial Disorders
Synonym: Bronchial disease
Synonym: Bronchial disorder
Synonym: Bronchospasm
Synonym: DISEASES OF THE BRONCHI
Tree Number: T10.8.5.4.2
database_cross_reference: AOD:0000005447
database_cross_reference: CHV:0000002180
database_cross_reference: CSP:2596-0903
database_cross_reference: DO:DOID:1176
database_cross_reference: HPO:HP:0002109
database_cross_reference: LCH_NW:sh85017070
database_cross_reference: MDR:10064913
database_cross_reference: MEDCIN:318913
database_cross_reference: MEDLINEPLUS:5977
database_cross_reference: MSH:D001982
database_cross_reference: NDFRT:N0000000614
database_cross_reference: PSY:07010
database_cross_reference: RCD:X104d
database_cross_reference: SNMI:D2-30000
database_cross_reference: SNOMEDCT_US:41427001
database_cross_reference: SNOMEDCT_VET:41427001

pericardial effusion
type: Class
subclass of: pericardium disease
definition: A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.
PMOID: PMO:00031605
Subclass_of: pericardium disease
Synonym: EFFUSION PERICARDIAL
Synonym: Effusion pericardial
Synonym: Effusion, Pericardial
Synonym: Effusions, Pericardial
Synonym: FLUID, PERICARDIAL
Synonym: Fluid in pericardium
Synonym: PERICARDIAL EFFUSION
Synonym: Pericardial Effusion
Synonym: Pericardial Effusion [Disease/Finding]
Synonym: Pericardial Effusions
Tree Number: T10.8.3.1.2
database_cross_reference: CCPSS:1017862
database_cross_reference: CHV:0000009486
database_cross_reference: COSTAR:U000522
database_cross_reference: CST:EFFUS PERICARD
database_cross_reference: DO:DOID:118
database_cross_reference: DXP:U003075
database_cross_reference: HPO:HP:0001698
database_cross_reference: MDR:10014311
database_cross_reference: MDR:10034474
database_cross_reference: MEDCIN:33465
database_cross_reference: MEDLINEPLUS:5664
database_cross_reference: MSH:D010490
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3319
database_cross_reference: NCI_CDISC:C3319
database_cross_reference: NCI_CTCAE:E10172
database_cross_reference: NCI_FDA:3271
database_cross_reference: NCI_NCI-GLOSS:CDR0000045825
database_cross_reference: NCI_NICHD:C3319
database_cross_reference: NDFRT:N0000002361
database_cross_reference: OMIM:MTHU005040
database_cross_reference: OMIM:MTHU012272
database_cross_reference: RCD:X201z
database_cross_reference: SNMI:D3-90050
database_cross_reference: SNOMEDCT_US:373945007
database_cross_reference: SNOMEDCT_US:70370001
database_cross_reference: SNOMEDCT_VET:373945007

multicentric reticulohistiocytosis
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis.
PMOID: PMO:00025165
Subclass_of: syndrome
Synonym: HISTIOCYTOMA, GIANT CELL
Synonym: LIPOID DERMATOARTHRITIS
Synonym: Lipoid dermato-arthritis
Synonym: Lipoid dermatoarthritis
Synonym: Lipoid dermatoarthritis (disorder)
Synonym: MR
Synonym: MRH
Synonym: Multicent reticulohistiocytos
Synonym: Multicentric Reticulohistiocytosis
Synonym: Multicentric reticulohistiocytosis
Tree Number: T10.1.46
database_cross_reference: CHV:0000028389
database_cross_reference: DO:DOID:11824
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001667
database_cross_reference: ICD10:M14.3
database_cross_reference: ICD10AM:M14.3
database_cross_reference: ICD10CM:E78.81
database_cross_reference: MDR:10070595
database_cross_reference: MEDCIN:273579
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:272.8
database_cross_reference: NCI:C27896
database_cross_reference: RCD:C32y2
database_cross_reference: RCD:X78qb
database_cross_reference: SNM:D-1376
database_cross_reference: SNMI:D6-64900
database_cross_reference: SNOMEDCT_US:190801003
database_cross_reference: SNOMEDCT_US:84241008

head and neck cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx.
PMOID: PMO:00026213
Subclass_of: organ system cancer
Synonym: HEAD NECK NEOPL
Synonym: Head and Neck Neoplasm
Synonym: Head and Neck Neoplasm (Excluding Central Nervous System)
Synonym: Head and Neck Neoplasms
Synonym: Head and Neck Neoplasms [Disease/Finding]
Synonym: Head and Neck Tumor
Synonym: Head and neck tumor
Synonym: Head, Neck Neoplasms
Synonym: NEOPL HEAD NECK
Synonym: Neoplasm of Head and Neck
Tree Number: T10.2.1.2.4
database_cross_reference: AOD:0000023037
database_cross_reference: CHV:0000005815
database_cross_reference: CSP:2005-4325
database_cross_reference: DO:DOID:11934
database_cross_reference: HPO:HP:0012288
database_cross_reference: MSH:D006258
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3077
database_cross_reference: NCI:TCGA
database_cross_reference: NDFRT:N0000001416
database_cross_reference: RCD:X78eD
database_cross_reference: RCDAE:X78eD
database_cross_reference: SNOMEDCT_US:255055008

esophagitis
type: Class
subclass of: esophageal disease
PMOID: PMO:00033443
Subclass_of: esophageal disease
Synonym: ESOPHAGITIS
Synonym: Esophagitides
Synonym: Esophagitis
Synonym: Esophagitis (disorder)
Synonym: Esophagitis NOS
Synonym: Esophagitis NOS (disorder)
Synonym: Esophagitis [Disease/Finding]
Synonym: Esophagitis, NOS
Synonym: Esophagitis, unspecified
Synonym: Inflammation of esophagus
Tree Number: T10.8.11.2.5
database_cross_reference: AOD:0000005538
database_cross_reference: BI:BI00246
database_cross_reference: CCPSS:0053782
database_cross_reference: CHV:0000004660
database_cross_reference: COSTAR:289
database_cross_reference: CST:ESOPHAGITIS
database_cross_reference: DO:DOID:11963
database_cross_reference: DXP:U001175
database_cross_reference: HPO:HP:0100633
database_cross_reference: ICD10:K20
database_cross_reference: ICD10AM:K20
database_cross_reference: ICD10AMAE:K20
database_cross_reference: ICD10CM:K20
database_cross_reference: ICD10CM:K20.9
database_cross_reference: ICD9CM:530.1
database_cross_reference: ICD9CM:530.10
database_cross_reference: ICPC2P:D84011
database_cross_reference: MDR:10015461
database_cross_reference: MDR:10015464
database_cross_reference: MDR:10030216
database_cross_reference: MDR:10030220
database_cross_reference: MDR:10072772
database_cross_reference: MEDCIN:30086
database_cross_reference: MSH:D004941
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:530.10
database_cross_reference: NCI:C9224
database_cross_reference: NCI_CTCAE:E10687
database_cross_reference: NCI_NCI-GLOSS:CDR0000044947
database_cross_reference: NCI_NICHD:C9224
database_cross_reference: NDFRT:N0000001165
database_cross_reference: OMIM:MTHU018345
database_cross_reference: RCD:J101.
database_cross_reference: RCD:J101z
database_cross_reference: RCDAE:J101.
database_cross_reference: RCDAE:J101z
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D5-30100
database_cross_reference: SNOMEDCT_US:155673008
database_cross_reference: SNOMEDCT_US:16761005
database_cross_reference: SNOMEDCT_US:196605000
database_cross_reference: SNOMEDCT_US:266498005
database_cross_reference: SNOMEDCT_VET:16761005

botulism
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction resulting in descending muscle paralysis, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F.
PMOID: PMO:00029581
Subclass_of: primary bacterial infectious disease
Synonym: (OS GIT infections) or (botulism) or (Campylobacter enteritis)
Synonym: (OS GIT infections) or (botulism) or (Campylobacter enteritis) (disorder)
Synonym: Botulism poisoning
Synonym: Food poisoning due to Clostridium botulinum
Synonym: Foodborne botulism
Synonym: Infection due to clostridium botulinum
Synonym: Intoxication with Clostridium botulinum toxin
Tree Number: T10.7.3.1.37
database_cross_reference: DO:DOID:11976
database_cross_reference: SNOMEDCT_US:154276003
database_cross_reference: SNOMEDCT_US:266177004

Prader-Willi syndrome
type: Class
subclass of: chromosomal disease
definition: A chromosomal disease that is characterized by weak muscle tone, feeding difficulties, poor growth, and delayed development. Beginning in childhood, affected individuals develop an insatiable appetite, which leads to chronic overeating and obesity.
PMOID: PMO:00028757
Subclass_of: chromosomal disease
Synonym: H2O syndrome
Synonym: Labhart Willi Prader Fanconi Syndrome
Synonym: Labhart Willi Syndrome
Synonym: Labhart-Willi Syndrome
Synonym: Labhart-Willi-Prader-Fanconi Syndrome
Synonym: OBESITY-CRYPTORCHIDISM-DWARFISM-SUBNORMAL MENTALITY SYNDROME
Synonym: PRADER WILLI SYNDROME
Synonym: PRADER-LABHART-WILLI SYNDROME
Synonym: PRADER-WILLI SYNDROME
Synonym: PWS
Tree Number: T10.5.9.2
database_cross_reference: CCPSS:0023549
database_cross_reference: CHV:0000010026
database_cross_reference: CSP:1849-7731
database_cross_reference: DO:DOID:11983
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001571
database_cross_reference: ICD10CM:Q87.1
database_cross_reference: ICD9CM:759.81
database_cross_reference: JABL:537
database_cross_reference: LCH:U003796
database_cross_reference: LCH_NW:sh85106050
database_cross_reference: MDR:10036476
database_cross_reference: MEDCIN:30417
database_cross_reference: MEDLINEPLUS:1243
database_cross_reference: MSH:D011218
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75463
database_cross_reference: NCI_NICHD:C75463
database_cross_reference: NDFRT:N0000002472
database_cross_reference: OMIM:176270
database_cross_reference: PSY:39867
database_cross_reference: RCD:PKy93
database_cross_reference: SNM:D-5089
database_cross_reference: SNMI:D4-00615
database_cross_reference: SNOMEDCT_US:205794007
database_cross_reference: SNOMEDCT_US:89392001

spermatocele
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029769
Subclass_of: male reproductive system disease
Synonym: Cyst of Epididymis
Synonym: Cyst of epididymis
Synonym: Cyst of epididymis (disorder)
Synonym: Cyst of the Epididymis
Synonym: Cyst, Epididymal
Synonym: Cyst;epididymal
Synonym: Cysts, Epididymal
Synonym: EPIDIDYMAL CYST
Synonym: EPIDIDYMIS, CYST
Synonym: Epididymal Cyst
Tree Number: T10.8.1.3.10
database_cross_reference: CCPSS:0051809
database_cross_reference: CCPSS:1007866
database_cross_reference: CHV:0000011587
database_cross_reference: CHV:0000023946
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:11997
database_cross_reference: DXP:U000574
database_cross_reference: HPO:HP:0030424
database_cross_reference: ICD10:N43.4
database_cross_reference: ICD10AM:N43.4
database_cross_reference: ICD10CM:N43.4
database_cross_reference: ICD10CM:N43.40
database_cross_reference: ICD10CM:N50.3
database_cross_reference: ICD9CM:608.1
database_cross_reference: ICPC2P:Y99002
database_cross_reference: ICPC2P:Y99012
database_cross_reference: MDR:10014994
database_cross_reference: MDR:10041490
database_cross_reference: MEDCIN:155114
database_cross_reference: MEDCIN:30715
database_cross_reference: MEDCIN:330825
database_cross_reference: MSH:D013088
database_cross_reference: NCI:C120909
database_cross_reference: NCI:C3865
database_cross_reference: NCI_CDISC:C120909
database_cross_reference: NDFRT:N0000002789
database_cross_reference: OMIM:MTHU015019
database_cross_reference: OMIM:MTHU018029
database_cross_reference: RCD:K281.
database_cross_reference: RCD:K28y6
database_cross_reference: SNM:M-33400
database_cross_reference: SNMI:D7-55170
database_cross_reference: SNMI:D7-55177
database_cross_reference: SNOMEDCT_US:155936007
database_cross_reference: SNOMEDCT_US:155941004
database_cross_reference: SNOMEDCT_US:43077002
database_cross_reference: SNOMEDCT_US:49263001

allergic hypersensitivity disease
type: Class
subclass of: hypersensitivity reaction disease
definition: An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.
PMOID: PMO:00032731
Subclass_of: hypersensitivity reaction disease
Synonym: (Allergy, unspecified) or (hypersensitivity NOS)
Synonym: (Allergy, unspecified) or (hypersensitivity NOS) (disorder)
Synonym: ALLERGIC REACTION
Synonym: ALLERGIC REACTION (NOS)
Synonym: ALLERGIC/HYPERSENSITIVITY
Synonym: ALLERGY
Synonym: Allergic Disorders
Synonym: Allergic Reaction
Synonym: Allergic disorder
Synonym: Allergic disorder (disorder)
Tree Number: T10.8.6.3.4
database_cross_reference: AOD:0000023559
database_cross_reference: BI:BI00743
database_cross_reference: CCPSS:0026478
database_cross_reference: CCPSS:0062443
database_cross_reference: CHV:0000006439
database_cross_reference: CHV:0000050654
database_cross_reference: CHV:0000057872
database_cross_reference: COSTAR:041
database_cross_reference: COSTAR:U000023
database_cross_reference: CSP:1524-8093
database_cross_reference: CST:ALLERG REACT
database_cross_reference: CST:PATHHYSN
database_cross_reference: DO:DOID:1205
database_cross_reference: DRUGBANK:DB00316
database_cross_reference: DRUGBANK:DB00388
database_cross_reference: DRUGBANK:DB00455
database_cross_reference: DRUGBANK:DB01075
database_cross_reference: DRUGBANK:DB01114
database_cross_reference: GO:GO:0002524
database_cross_reference: HPO:HP:0012393
database_cross_reference: ICD10:T78.4
database_cross_reference: ICD10AM:T78.4
database_cross_reference: ICD10CM:T78.40
database_cross_reference: ICPC2EENG:A92
database_cross_reference: ICPC2P:A12007
database_cross_reference: ICPC2P:A12009
database_cross_reference: ICPC2P:A92007
database_cross_reference: ICPC2P:A92008
database_cross_reference: LCH_NW:sh85003662
database_cross_reference: LNC:LA17771-9
database_cross_reference: LNC:LP20697-6
database_cross_reference: LNC:LP31625-4
database_cross_reference: LNC:LP7756-2
database_cross_reference: LNC:MTHU020822
database_cross_reference: MDR:10001738
database_cross_reference: MDR:10001741
database_cross_reference: MDR:10020751
database_cross_reference: MDR:10020755
database_cross_reference: MDR:10020756
database_cross_reference: MDR:10020757
database_cross_reference: MDR:10020759
database_cross_reference: MDR:10021150
database_cross_reference: MDR:10037948
database_cross_reference: MDR:10048495
database_cross_reference: MEDLINEPLUS:24
database_cross_reference: MSH:D006967
database_cross_reference: MTH:042
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:995.3
database_cross_reference: NCI:C3114
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_FDA:1907
database_cross_reference: NCI_NCI-GLOSS:CDR0000045715
database_cross_reference: NCI_NICHD:C3114
database_cross_reference: NDFRT:N0000001610
database_cross_reference: OMIM:MTHU030932
database_cross_reference: OMIM:MTHU047042
database_cross_reference: PSY:01830
database_cross_reference: RCD:X79pp
database_cross_reference: RCD:X79pv
database_cross_reference: RCD:XE1ot
database_cross_reference: RCD:XM0xz
database_cross_reference: RCD:Xa1pQ
database_cross_reference: RCD:Xa1zh

Rett syndrome
type: Class
subclass of: pervasive developmental disorder
definition: A pervasive developmental disease that is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability.
PMOID: PMO:00028124
Subclass_of: pervasive developmental disorder
Synonym: AUTISM, DEMENTIA, ATAXIA, AND LOSS OF PURPOSEFUL HAND USE
Synonym: Autism Dementia Ataxia Loss of Purposeful Hand Use Syndrome
Synonym: Autism, Dementia, Ataxia, and Loss of Purposeful Hand Use
Synonym: Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome
Synonym: Cerebroatrophic Hyperammonemia
Synonym: Cerebroatrophic Hyperammonemias
Synonym: Cerebroatrophic hyperammonaemia
Synonym: Cerebroatrophic hyperammonemia
Synonym: Hyperammonemia, Cerebroatrophic
Synonym: Hyperammonemias, Cerebroatrophic
Tree Number: T10.3.5.2.3
database_cross_reference: CCPSS:0041853
database_cross_reference: CHV:0000010824
database_cross_reference: CSP:4001-0114
database_cross_reference: DO:DOID:1206
database_cross_reference: ICD10:F84.2
database_cross_reference: ICD10AM:F84.2
database_cross_reference: ICD10CM:F84.2
database_cross_reference: JABL:556
database_cross_reference: LCH_NW:sh86003783
database_cross_reference: MDR:10039000
database_cross_reference: MDR:10077709
database_cross_reference: MEDCIN:36376
database_cross_reference: MEDLINEPLUS:4272
database_cross_reference: MSH:D015518
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75488
database_cross_reference: NCI_NICHD:C75488
database_cross_reference: NDFRT:N0000003280
database_cross_reference: OMIM:300005
database_cross_reference: OMIM:312750
database_cross_reference: PSY:44482
database_cross_reference: RCD:X005S
database_cross_reference: SNMI:D9-18120
database_cross_reference: SNOMEDCT_US:192583003
database_cross_reference: SNOMEDCT_US:68618008

Dieulafoy lesion
type: Class
subclass of: stomach disease
PMOID: PMO:00033452
Subclass_of: stomach disease
Synonym: Caliber persistent artery
Synonym: Calibre persistent artery
Synonym: Dieulafoy disease
Synonym: Dieulafoy lesion of stomach
Synonym: Dieulafoy lesion of stomach (diagnosis)
Synonym: Dieulafoy vascular malformation
Synonym: Dieulafoy's vascular malformation
Synonym: Dieulafoy's vascular malformation (disorder)
Synonym: Ulcer, Dieulafoy's
Synonym: dieulafoy disease
Tree Number: T10.8.11.3.1
database_cross_reference: CHV:0000030659
database_cross_reference: MDR:10067743
database_cross_reference: MEDCIN:272345
database_cross_reference: RCD:X301u
database_cross_reference: SNM:M-38050
database_cross_reference: SNOMEDCT_US:109558001

pylorospasm
type: Class
subclass of: stomach disease
PMOID: PMO:00033475
Subclass_of: stomach disease
Synonym: PYLOROSPASM
Synonym: Pylorospasm
Synonym: Pylorospasm (disorder)
Synonym: SPASM PYLORIC
Synonym: Spasm pyloric
Synonym: pyloric spasm
Synonym: pyloric spasms
Synonym: pylorospasm (diagnosis)
Synonym: pylorospasms
Tree Number: T10.8.11.3.7
database_cross_reference: CHV:0000017193
database_cross_reference: CST:DYSPEPSIA
database_cross_reference: DO:DOID:12072
database_cross_reference: ICD9CM:537.81
database_cross_reference: MDR:10037628
database_cross_reference: MDR:10041401
database_cross_reference: MEDCIN:34942
database_cross_reference: RCD:J17y0
database_cross_reference: SNM:F-61520
database_cross_reference: SNMI:D5-32780
database_cross_reference: SNOMEDCT_US:335002

sodoku disease
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.
PMOID: PMO:00029529
Subclass_of: primary bacterial infectious disease
Synonym: Spirillary fever
Tree Number: T10.7.3.1.24
database_cross_reference: DO:DOID:12096

vaginal disease
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is located_in the vagina.
PMOID: PMO:00029798
Subclass_of: female reproductive system disease
Synonym: Disease of vagina
Synonym: Disease of vagina (disorder)
Synonym: Disease of vagina, NOS
Synonym: Disease, Vaginal
Synonym: Diseases, Vaginal
Synonym: Disorder of vagina
Synonym: Disorder of vagina (disorder)
Synonym: VAGINAL DIS
Synonym: Vagina--Diseases
Synonym: Vaginal Disease
Tree Number: T10.8.1.4.3
database_cross_reference: CHV:0000012868
database_cross_reference: CHV:0000048275
database_cross_reference: CSP:2587-6329
database_cross_reference: CST:UG/FG/VAG
database_cross_reference: DO:DOID:121
database_cross_reference: LCH_NW:sh85141757
database_cross_reference: MDR:10046903
database_cross_reference: MDR:10061402
database_cross_reference: MEDCIN:34235
database_cross_reference: MEDLINEPLUS:451
database_cross_reference: MSH:D014623
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26910
database_cross_reference: NDFRT:N0000003104
database_cross_reference: RCD:Xa06n
database_cross_reference: RCD:Xa3g4
database_cross_reference: SNMI:D7-70050
database_cross_reference: SNOMEDCT_US:156015000
database_cross_reference: SNOMEDCT_US:156018003
database_cross_reference: SNOMEDCT_US:25658005
database_cross_reference: SNOMEDCT_US:266665005
database_cross_reference: SNOMEDCT_US:286989007

factor VIII deficiency
type: Class
subclass of: X-linked disease
definition: An X-linked disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait.
PMOID: PMO:00028735
Subclass_of: X-linked disease
Synonym: AHG DEFICIENCY
Synonym: AHG deficiency
Synonym: AHG deficiency disease
Synonym: ANTIHEMOPHILIC FACTOR A DEFICIENCY
Synonym: ANTIHEMOPHILIC GLOBULIN DEFICIENCY
Synonym: Antihemophilic globulin deficiency
Synonym: Classic Hemophilia
Synonym: Classic Hemophilias
Synonym: Classical haemophilia
Synonym: Classical hemophilia
Tree Number: T10.5.3.4.15
database_cross_reference: CCPSS:0032174
database_cross_reference: CHV:0000006005
database_cross_reference: CSP:0438-6751
database_cross_reference: DO:DOID:12134
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000623
database_cross_reference: ICD10CM:D66
database_cross_reference: ICD9CM:286.0
database_cross_reference: MDR:10010468
database_cross_reference: MDR:10018937
database_cross_reference: MDR:10018938
database_cross_reference: MDR:10060612
database_cross_reference: MDR:10060613
database_cross_reference: MEDCIN:30315
database_cross_reference: MSH:D006467
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:286.0
database_cross_reference: NCI:C27146
database_cross_reference: NCI_NICHD:C27146
database_cross_reference: NDFRT:N0000001478
database_cross_reference: OMIM:300841
database_cross_reference: OMIM:306700
database_cross_reference: RCD:D300.
database_cross_reference: RCD:X20ED
database_cross_reference: RCDAE:D300.
database_cross_reference: SNM:D-4428
database_cross_reference: SNMI:DC-63120
database_cross_reference: SNOMEDCT_US:28293008

dysthymic disorder
type: Class
subclass of: mood disorder
definition: A mood disorder that involves the presence of a low mood almost daily over a span of at least two years.
PMOID: PMO:00028197
Subclass_of: mood disorder
Synonym: DYSTHYMIC DIS
Synonym: DYSTHYMIC DISORDER
Synonym: Disorder, Dysthymic
Synonym: Dysthymia
Synonym: Dysthymia (disorder)
Synonym: Dysthymia, NOS
Synonym: Dysthymic Disorder
Synonym: Dysthymic Disorder [Disease/Finding]
Synonym: Dysthymic Disorders
Synonym: Dysthymic disorder
Tree Number: T10.3.12.2.1
database_cross_reference: AOD:0000006619
database_cross_reference: AOD:0000023959
database_cross_reference: CCPSS:1017910
database_cross_reference: CHV:0000004218
database_cross_reference: CSP:2483-6681
database_cross_reference: DO:DOID:12139
database_cross_reference: DSM-5:300.4
database_cross_reference: DSM-5:F34.1
database_cross_reference: DXP:U000504
database_cross_reference: ICD10:F34.1
database_cross_reference: ICD10AM:F34.1
database_cross_reference: ICD10CM:F34.1
database_cross_reference: ICD9CM:300.4
database_cross_reference: MDR:10013981
database_cross_reference: MDR:10013982
database_cross_reference: MEDCIN:32774
database_cross_reference: MEDCIN:362679
database_cross_reference: MEDLINEPLUS:113
database_cross_reference: MSH:D019263
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34562
database_cross_reference: NDFRT:N0000003907
database_cross_reference: PSY:15690
database_cross_reference: PSY:15693
database_cross_reference: RCD:E2112
database_cross_reference: SNMI:D9-52300
database_cross_reference: SNOMEDCT_US:192384008
database_cross_reference: SNOMEDCT_US:78667006

neurogenic bladder
type: Class
subclass of: bladder disease
PMOID: PMO:00033091
Subclass_of: bladder disease
Synonym: BLADDER DIS NEUROGENIC
Synonym: BLADDER NEUROGENIC
Synonym: Bladder Disorder, Neurogenic
Synonym: Bladder neurogenic
Synonym: Bladder, Neurogenic
Synonym: NEUROGENIC BLADDER
Synonym: NEUROGENIC BLADDER DIS
Synonym: NEUROGENIC URINARY BLADDER DIS
Synonym: Neurogenic Bladder
Synonym: Neurogenic Bladder Disorder
Tree Number: T10.8.7.11.4
database_cross_reference: BI:BI00421
database_cross_reference: CCPSS:0045758
database_cross_reference: CHV:0000001957
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:3045-9211
database_cross_reference: CST:INCONTIN URIN
database_cross_reference: DO:DOID:12143
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0000011
database_cross_reference: ICD9CM:596.54
database_cross_reference: ICPC2P:N99029
database_cross_reference: LCH:U003189
database_cross_reference: LCH_NW:sh85091123
database_cross_reference: MDR:10005059
database_cross_reference: MDR:10029279
database_cross_reference: MDR:10029280
database_cross_reference: MDR:10029327
database_cross_reference: MEDCIN:30650
database_cross_reference: MEDLINEPLUS:164
database_cross_reference: MSH:D001750
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C79696
database_cross_reference: NCI_NICHD:C79696
database_cross_reference: NDFRT:N0000000565
database_cross_reference: OMIM:MTHU037120
database_cross_reference: RCD:X30Nj
database_cross_reference: SNM:F-65890
database_cross_reference: SNMI:F-72150
database_cross_reference: SNOMEDCT_US:155032006
database_cross_reference: SNOMEDCT_US:192972000
database_cross_reference: SNOMEDCT_US:197883004
database_cross_reference: SNOMEDCT_US:23201000
database_cross_reference: SNOMEDCT_US:397732007
database_cross_reference: SNOMEDCT_US:398064005

low compliance bladder
type: Class
subclass of: bladder disease
PMOID: PMO:00033093
Subclass_of: bladder disease
Synonym: Low bladder compliance
Synonym: Low compliance bladder
Synonym: Low compliance bladder (disorder)
Synonym: hyperactivity of bladder
Synonym: hypertonic bladder
Synonym: hypertonicity of bladder
Synonym: lower bladder compliance
Synonym: lower bladder compliance (diagnosis)
Tree Number: T10.8.7.11.6
database_cross_reference: DO:DOID:12144
database_cross_reference: ICD9CM:596.52
database_cross_reference: MDR:10024894
database_cross_reference: MEDCIN:96715
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X30Nu
database_cross_reference: SNMI:D7-21610
database_cross_reference: SNOMEDCT_US:9009001

detrusor sphincter dyssynergia
type: Class
subclass of: bladder disease
PMOID: PMO:00033092
Subclass_of: bladder disease
Synonym: DSD - Detrusor and sphincter dyssynergia
Synonym: DSD - Detrusr/sphnct dyssynerg
Synonym: Detrusor and sphincter dyssynergia
Synonym: Detrusor and sphincter dyssynergia (disorder)
Synonym: Detrusor sphincter dyssynergia
Synonym: Detrusor/sphincter dyssynergia
Synonym: Detrusr sphinc dyssnrgia
Synonym: Detrussor dyssynergia
Synonym: detrusor sphincter dyssynergia (diagnosis)
Tree Number: T10.8.7.11.5
database_cross_reference: DO:DOID:12145
database_cross_reference: HPO:HP:0025488
database_cross_reference: ICD9CM:596.55
database_cross_reference: MDR:10012550
database_cross_reference: MEDCIN:96717
database_cross_reference: RCD:X30OB
database_cross_reference: SNM:F-66320
database_cross_reference: SNOMEDCT_US:236655005

lymphocytic choriomeningitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.
PMOID: PMO:00029397
Subclass_of: viral infectious disease
Synonym: Armstrong Syndrome
Synonym: Armstrong's Syndrome
Synonym: Armstrong's disease
Synonym: CHORIOMENINGITIS, LYMPHOCYTIC
Synonym: Choriomeningitis lymphocytic
Synonym: Choriomeningitis, Lymphocytic
Synonym: ENCEPH LYMPHOCYTIC CHORIOMENINGITIS VIRUS
Synonym: Encephalomyelitis caused by lymphocytic choriomeningitis virus
Synonym: Encephalomyelitis caused by lymphocytic choriomeningitis virus (disorder)
Synonym: Encephalomyelitis, Lymphocytic Choriomeningitis Virus
Tree Number: T10.7.2.41
database_cross_reference: CCPSS:0027431
database_cross_reference: CHV:0000007610
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2042-5332
database_cross_reference: DO:DOID:12155
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000349
database_cross_reference: ICD10:A87.2
database_cross_reference: ICD10AM:A87.2
database_cross_reference: ICD10CM:A87.2
database_cross_reference: ICPC2P:N71007
database_cross_reference: LCH:U002761
database_cross_reference: LCH_NW:sh85079148
database_cross_reference: MDR:10008761
database_cross_reference: MDR:10024047
database_cross_reference: MDR:10025266
database_cross_reference: MDR:10025267
database_cross_reference: MDR:10027219
database_cross_reference: MDR:10070611
database_cross_reference: MEDCIN:31087
database_cross_reference: MSH:D008216
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001902
database_cross_reference: RCD:A4z0.
database_cross_reference: SNM:D-0425
database_cross_reference: SNMI:DE-34A10
database_cross_reference: SNOMEDCT_US:186495001
database_cross_reference: SNOMEDCT_US:192668002
database_cross_reference: SNOMEDCT_US:276064006
database_cross_reference: SNOMEDCT_US:276817007
database_cross_reference: SNOMEDCT_US:38666007
database_cross_reference: SNOMEDCT_US:397961002
database_cross_reference: SNOMEDCT_US:398136003
database_cross_reference: SNOMEDCT_US:721781004

aseptic meningitis
type: Class
subclass of: viral meningitis
PMOID: PMO:00029449
Subclass_of: viral meningitis
Synonym: Aseptic Meningitis
Synonym: Aseptic meningitis
Synonym: Aseptic meningitis (disorder)
Synonym: MENINGITIS ASEPTIC
Synonym: MENINGITIS, ASEPTIC
Synonym: Meningitis aseptic
Synonym: Meningitis, Aseptic
Synonym: Meningitis, Aseptic [Disease/Finding]
Synonym: acute aseptic meningitis
Synonym: aseptic meningitis (diagnosis)
Tree Number: T10.7.2.79.1
database_cross_reference: BI:BI00519
database_cross_reference: CCPSS:0028764
database_cross_reference: CHV:0000007933
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:12157
database_cross_reference: DXP:U001157
database_cross_reference: ICD10CM:G03.0
database_cross_reference: MDR:10003458
database_cross_reference: MDR:10027201
database_cross_reference: MEDCIN:31193
database_cross_reference: MEDLINEPLUS:324
database_cross_reference: MSH:D008582
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118299
database_cross_reference: NCI_NICHD:C118299
database_cross_reference: NDFRT:N0000001982
database_cross_reference: RCD:Xa84l
database_cross_reference: SNM:D-0500
database_cross_reference: SNOMEDCT_US:186490006
database_cross_reference: SNOMEDCT_US:301770000
database_cross_reference: SNOMEDCT_US:58170007

fascioloidiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the liver of a variety of wild and domestic ruminants by Fascioloides magna.
PMOID: PMO:00029646
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.24
database_cross_reference: DO:DOID:1217

goiter
type: Class
subclass of: thyroid gland disease
definition: An endocrine system disease that is located_in the thyroid.
PMOID: PMO:00033160
Subclass_of: thyroid gland disease
Synonym: Abnormality of the thyroid gland
Synonym: B-80 HYPOTHYROIDISM, HYPERTHYROIDISM AND OTHER DISORDERS
Synonym: DISEASES OF THE THYROID GLAND
Synonym: DISORDER THYROID
Synonym: DISORDERS OF THYROID GLAND
Synonym: Disease of thyroid gland
Synonym: Disease of thyroid gland (disorder)
Synonym: Disease of thyroid gland, NOS
Synonym: Disease, Thyroid
Synonym: Diseases of Thyroid Gland
Tree Number: T10.8.8.3.3
database_cross_reference: AOD:0000005981
database_cross_reference: CCPSS:0034188
database_cross_reference: CCPSS:0056633
database_cross_reference: CHV:0000012259
database_cross_reference: CHV:0000048209
database_cross_reference: COSTAR:U000061
database_cross_reference: COSTAR:U000674
database_cross_reference: CSP:2928-6228
database_cross_reference: CST:ENDO/THYR
database_cross_reference: CST:THYR DIS
database_cross_reference: DO:DOID:12176
database_cross_reference: DO:DOID:50
database_cross_reference: HPO:HP:0000820
database_cross_reference: ICD10:E00-E07.9
database_cross_reference: ICD10:E07.9
database_cross_reference: ICD10AM:E00-E07.9
database_cross_reference: ICD10AM:E07.9
database_cross_reference: ICD10CM:E00-E07
database_cross_reference: ICD10CM:E07.9
database_cross_reference: ICD9CM:240-246.99
database_cross_reference: ICD9CM:246.9
database_cross_reference: LCH_NW:sh85135167
database_cross_reference: LNC:LA15157-3
database_cross_reference: LNC:LA17778-4
database_cross_reference: MDR:10013274
database_cross_reference: MDR:10043709
database_cross_reference: MDR:10043710
database_cross_reference: MDR:10043739
database_cross_reference: MDR:10045832
database_cross_reference: MEDCIN:90715
database_cross_reference: MEDLINEPLUS:439
database_cross_reference: MSH:D013959
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26893
database_cross_reference: NDFRT:N0000002942
database_cross_reference: OMIM:MTHU018343
database_cross_reference: OMIM:MTHU053945
database_cross_reference: PSY:53090
database_cross_reference: RCD:C06z.
database_cross_reference: RCD:XE100
database_cross_reference: SNM:D-2180
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DB-80000
database_cross_reference: SNOMEDCT_US:14304000
database_cross_reference: SNOMEDCT_US:154649009
database_cross_reference: SNOMEDCT_US:190232008
database_cross_reference: SNOMEDCT_US:190311002
database_cross_reference: SNOMEDCT_US:191036006

echinostomiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Metagonimus yokogawai. The symptoms are diarrhea and colicky abdominal pain. The heart and brain can also be infected.
PMOID: PMO:00029625
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Echinochasmus
Synonym: Infection by Metagonimus yokogawai
Synonym: Watsoniasis
Synonym: heterophyes infectious disease
Synonym: heterophyiasis
Synonym: metagonimiasis
Tree Number: T10.7.4.1.8
database_cross_reference: DO:DOID:1218
database_cross_reference: DO:DOID:882
database_cross_reference: DO:DOID:884
database_cross_reference: ICD10CM:B66.8

dicrocoeliasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Dicrocoelium dendriticum. The symptoms include cholecystitis, liver abscesses and upper abdominal pain.
PMOID: PMO:00029642
Subclass_of: parasitic helminthiasis infectious disease
Synonym: disease due to Dicrocoeliidae
Tree Number: T10.7.4.1.20
database_cross_reference: DO:DOID:1219

dengue disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection, has material basis in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.
PMOID: PMO:00029383
Subclass_of: viral infectious disease
Synonym: Break Bone Fever
Synonym: Break-Bone Fever
Synonym: Break-bone Fever
Synonym: Break-bone fever
Synonym: Breakbone Fever
Synonym: Breakbone fever
Synonym: Classical Dengue
Synonym: Classical Dengue Fever
Synonym: Classical Dengue Fevers
Synonym: Classical Dengues
Tree Number: T10.7.2.33
database_cross_reference: CHV:0000003697
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:3100-2165
database_cross_reference: DO:DOID:12205
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000453
database_cross_reference: ICD10:A90
database_cross_reference: ICD10AM:A90
database_cross_reference: ICD10CM:A90
database_cross_reference: ICD9CM:061
database_cross_reference: ICPC2P:A77002
database_cross_reference: LCH:U001296
database_cross_reference: LCH_NW:sh85036728
database_cross_reference: LNC:LA10451-5
database_cross_reference: MDR:10012309
database_cross_reference: MDR:10012310
database_cross_reference: MDR:10012312
database_cross_reference: MEDCIN:30833
database_cross_reference: MEDLINEPLUS:3104
database_cross_reference: MSH:D003715
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:061
database_cross_reference: NCI:C34528
database_cross_reference: NCI_NICHD:C34528
database_cross_reference: NDFRT:N0000000916
database_cross_reference: RCD:A61..
database_cross_reference: SNM:D-0381
database_cross_reference: SNMI:DE-33330
database_cross_reference: SNOMEDCT_US:154345006
database_cross_reference: SNOMEDCT_US:266194002
database_cross_reference: SNOMEDCT_US:38362002

dengue hemorrhagic fever
type: Class
subclass of: dengue disease
definition: A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever.
PMOID: PMO:00029384
Subclass_of: dengue disease
Synonym: DENGUE HEMORRHAGIC FEVER
Synonym: DHF
Synonym: DHF - Dengue haemorrhag fever
Synonym: DHF - Dengue haemorrhagic fever
Synonym: DHF - Dengue hemorrhagic fever
Synonym: DOUBLE DENGUE HEMORRHAGIC DISEASE
Synonym: Dengue Hemorrhagic Fever
Synonym: Dengue haemorrhagic fever
Synonym: Dengue haemorrhagic fever (disorder)
Synonym: Dengue hemorrhagic fever
Tree Number: T10.7.2.33.1
database_cross_reference: CHV:0000006016
database_cross_reference: DO:DOID:12206
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000454
database_cross_reference: ICD10:A91
database_cross_reference: ICD10AM:A91
database_cross_reference: ICD10AMAE:A91
database_cross_reference: ICD10CM:A91
database_cross_reference: MDR:10012313
database_cross_reference: MDR:10055776
database_cross_reference: MEDCIN:97447
database_cross_reference: MSH:D019595
database_cross_reference: MTHICD9:065.4
database_cross_reference: NCI:C34683
database_cross_reference: NDFRT:N0000003948
database_cross_reference: RCD:X70Jw
database_cross_reference: RCDAE:X70Jw
database_cross_reference: SNM:D-0380
database_cross_reference: SNMI:DE-33338
database_cross_reference: SNOMEDCT_US:186598001
database_cross_reference: SNOMEDCT_US:186599009
database_cross_reference: SNOMEDCT_US:20927009

Lewy body dementia
type: Class
subclass of: dementia
definition: A dementia and a synucleinopathy that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities.
PMOID: PMO:00028213
Subclass_of: dementia
Synonym: CLBD - Cortical Lewy body dis
Synonym: CLBD - Cortical Lewy body disease
Synonym: CORTICAL LEWY BODY DIS
Synonym: Cortical Lewy Body Disease
Synonym: Cortical Lewy body disease
Synonym: DEMENTIA, LEWY BODY
Synonym: DIFFUSE LEWY BODY DIS
Synonym: DIFFUSE LEWY BODY DISEASE
Synonym: DLB
Synonym: DLBD - Diffuse Lewy body dis
Tree Number: T10.3.12.3.2
database_cross_reference: CHV:0000048575
database_cross_reference: DO:DOID:12217
database_cross_reference: HPO:HP:0100315
database_cross_reference: ICD10CM:G31.83
database_cross_reference: ICD9CM:331.82
database_cross_reference: LCH_NW:sh96004033
database_cross_reference: MDR:10057095
database_cross_reference: MDR:10067889
database_cross_reference: MEDCIN:272878
database_cross_reference: MEDCIN:352588
database_cross_reference: MEDLINEPLUS:4070
database_cross_reference: MSH:D020961
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:331.82
database_cross_reference: NCI:C84826
database_cross_reference: NDFRT:N0000004234
database_cross_reference: OMIM:127750
database_cross_reference: OMIM:163890
database_cross_reference: OMIM:602569
database_cross_reference: PSY:13435
database_cross_reference: PSY:28291
database_cross_reference: RCD:X003A
database_cross_reference: RCD:XaE74
database_cross_reference: SNMI:DA-21036
database_cross_reference: SNOMEDCT_US:192808003
database_cross_reference: SNOMEDCT_US:230275004
database_cross_reference: SNOMEDCT_US:230276003
database_cross_reference: SNOMEDCT_US:230277007
database_cross_reference: SNOMEDCT_US:312991009
database_cross_reference: SNOMEDCT_US:80098002

cartilage disease
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032308
Subclass_of: connective tissue disease
Synonym: CARTILAGE DIS
Synonym: Cartilage Disease
Synonym: Cartilage Diseases
Synonym: Cartilage Diseases [Disease/Finding]
Synonym: Cartilage Disorders
Synonym: Cartilage disorder
Synonym: Cartilage disorder (disorder)
Synonym: Cartilage disorder NOS
Synonym: Cartilage disorder, functional
Synonym: Cartilage disorders
Tree Number: T10.8.4.1.20
database_cross_reference: CHV:0000002497
database_cross_reference: CSP:2715-1779
database_cross_reference: CST:MS/CART
database_cross_reference: DO:DOID:1222
database_cross_reference: ICD10:M91-M94.9
database_cross_reference: ICD10:M94.9
database_cross_reference: ICD10AM:M91-M94.9
database_cross_reference: ICD10AM:M94.9
database_cross_reference: ICD10CM:M91-M94
database_cross_reference: ICD10CM:M94.9
database_cross_reference: LCH_NW:sh85020510
database_cross_reference: MDR:10007707
database_cross_reference: MDR:10007708
database_cross_reference: MDR:10007709
database_cross_reference: MDR:10051395
database_cross_reference: MDR:10061762
database_cross_reference: MEDCIN:334026
database_cross_reference: MEDLINEPLUS:1412
database_cross_reference: MSH:D002357
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000694
database_cross_reference: RCD:N32..
database_cross_reference: RCD:NyuD.
database_cross_reference: RCD:NyuDE
database_cross_reference: RCD:XaBMT
database_cross_reference: RCDSY:NyuD.
database_cross_reference: RCDSY:NyuDE
database_cross_reference: SNM:F-89702
database_cross_reference: SNMI:F-12902
database_cross_reference: SNOMEDCT_US:203526003
database_cross_reference: SNOMEDCT_US:203908009
database_cross_reference: SNOMEDCT_US:203914002
database_cross_reference: SNOMEDCT_US:268062001
database_cross_reference: SNOMEDCT_US:268126004
database_cross_reference: SNOMEDCT_US:308148004
database_cross_reference: SNOMEDCT_US:367355001
database_cross_reference: SNOMEDCT_US:50927007

cascade stomach
type: Class
subclass of: stomach disease
PMOID: PMO:00033481
Subclass_of: stomach disease
Synonym: Cascade stomach
Synonym: Cascade stomach (disorder)
Synonym: Hourglass stomach
Synonym: Hourglass stricture and stenosis of stomach
Synonym: Hourglass stricture or stenosis of stomach
Synonym: Hourglass stricture stom
Tree Number: T10.8.11.3.10
database_cross_reference: DO:DOID:12234
database_cross_reference: ICD10:K31.2
database_cross_reference: ICD10AM:K31.2
database_cross_reference: ICD10CM:K31.2
database_cross_reference: ICD9CM:537.6
database_cross_reference: MDR:10020418
database_cross_reference: MDR:10075069
database_cross_reference: MTHICD9:537.6
database_cross_reference: SNM:M-34160
database_cross_reference: SNMI:D5-32768
database_cross_reference: SNOMEDCT_US:54051005

medulloadrenal hyperfunction
type: Class
subclass of: adrenal gland disease
PMOID: PMO:00033229
Subclass_of: adrenal gland disease
Synonym: Adrenal medulla hyperfunction
Synonym: Adrenomedullary hyperfunction
Synonym: Medulloadrenal hyperfunc
Synonym: Medulloadrenal hyperfunction
Synonym: Medulloadrenal hyperfunction (disorder)
Synonym: medulloadrenal hyperfunction (diagnosis)
Tree Number: T10.8.8.6.1
database_cross_reference: DO:DOID:12257
database_cross_reference: ICD10:E27.5
database_cross_reference: ICD10AM:E27.5
database_cross_reference: ICD10CM:E27.5
database_cross_reference: ICD9CM:255.6
database_cross_reference: MDR:10001371
database_cross_reference: MDR:10027106
database_cross_reference: MEDCIN:99859
database_cross_reference: RCD:C156.
database_cross_reference: SNMI:DB-70840
database_cross_reference: SNOMEDCT_US:111565003

Crimean-Congo hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.
PMOID: PMO:00029428
Subclass_of: viral infectious disease
Synonym: CCHF
Synonym: CCHF - Crimea-Congo haem fever
Synonym: CCHF - Crimean-Congo haemorrhagic fever
Synonym: CCHF - Crimean-Congo hemorrhagic fever
Synonym: CHF - Crimean haemorrhag fever
Synonym: CHF - Crimean haemorrhagic fever
Synonym: CHF - Crimean hemorrhagic fever
Synonym: CHF Congo virus
Synonym: CONGO VIRUS INFECT
Synonym: Central Asian haemorrhag fever
Tree Number: T10.7.2.62
database_cross_reference: CHV:0000006015
database_cross_reference: DO:DOID:12287
database_cross_reference: DXP:U000802
database_cross_reference: ICD10:A98.0
database_cross_reference: ICD10AM:A98.0
database_cross_reference: ICD10AMAE:A98.0
database_cross_reference: ICD10CM:A98.0
database_cross_reference: ICD9CM:065.0
database_cross_reference: MDR:10010685
database_cross_reference: MDR:10010686
database_cross_reference: MDR:10011388
database_cross_reference: MDR:10011389
database_cross_reference: MDR:10011390
database_cross_reference: MDR:10060532
database_cross_reference: MDR:10060533
database_cross_reference: MDR:10060534
database_cross_reference: MEDCIN:30851
database_cross_reference: MSH:D006479
database_cross_reference: MTHICD9:065.0
database_cross_reference: NCI:C34682
database_cross_reference: NCI_NICHD:C34682
database_cross_reference: NDFRT:N0000001488
database_cross_reference: RCD:A650.
database_cross_reference: RCDAE:A650.
database_cross_reference: SNM:D-0375
database_cross_reference: SNMI:DE-34710
database_cross_reference: SNOMEDCT_US:43489008

atypical depressive disorder
type: Class
subclass of: mood disorder
definition: A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.
PMOID: PMO:00028204
Subclass_of: mood disorder
Synonym: Atypical depression
Synonym: Atypical depressive dis
Synonym: Atypical depressive disorder
Synonym: Atypical depressive disorder (disorder)
Synonym: [X]Atypical depression
Synonym: atypical depression
Synonym: atypical depressive disorder (diagnosis)
Tree Number: T10.3.12.2.3
database_cross_reference: AOD:0000006521
database_cross_reference: CHV:0000017397
database_cross_reference: DO:DOID:12294
database_cross_reference: ICD10CM:F32.89
database_cross_reference: ICD9CM:296.82
database_cross_reference: MDR:10003748
database_cross_reference: MEDCIN:32776
database_cross_reference: RCD:E11y2
database_cross_reference: SNM:D-9119
database_cross_reference: SNOMEDCT_US:191659001
database_cross_reference: SNOMEDCT_US:192371004
database_cross_reference: SNOMEDCT_US:277538003

Dubin-Johnson syndrome
type: Class
subclass of: bilirubin metabolic disorder
definition: A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin without elevation of liver alanine transaminase and aspartate transaminase enzymes as a result of the deficient ability of hepatocytes to secrete conjugated bilirubin into the bile.
PMOID: PMO:00028999
Subclass_of: bilirubin metabolic disorder
Synonym: Black liver-jaundice syndrome
Synonym: CHRONIC IDIOPATHIC JAUNDICE
Synonym: Chronic Idiopathic Jaundice
Synonym: Chronic Idiopathic Jaundices
Synonym: Chronic idiopathic jaundice
Synonym: Chronic idiopathic jaundice with pigmented liver
Synonym: DJS
Synonym: DJS - Dubin-Johnson syndrome
Synonym: DUBIN-JOHNSON SYNDROME
Synonym: DUBIN-SPRINZ DISEASE
Tree Number: T10.6.2.3.3
database_cross_reference: CHV:0000006992
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1654-1020
database_cross_reference: DO:DOID:12308
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000493
database_cross_reference: ICD10CM:E80.6
database_cross_reference: MDR:10013800
database_cross_reference: MEDCIN:30046
database_cross_reference: MSH:D007566
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.4
database_cross_reference: NCI:C34741
database_cross_reference: NDFRT:N0000001715
database_cross_reference: OMIM:237500
database_cross_reference: OMIM:601107
database_cross_reference: RCD:C3741
database_cross_reference: SNM:D-1507
database_cross_reference: SNMI:D6-85500
database_cross_reference: SNOMEDCT_US:44553005

hematocele of tunica vaginalis testis
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029768
Subclass_of: male reproductive system disease
Synonym: Haematocele
Synonym: Haematocele of tunica vaginalis testis
Synonym: Haematocoele
Synonym: Haematocoele of tunica vaginalis testis
Synonym: Hematocele
Synonym: Hematocele NOS, male
Synonym: Hematocele [Disease/Finding]
Synonym: Hematocele of tunica vaginalis testis
Synonym: Hematoceles
Synonym: Male haematocele
Tree Number: T10.8.1.3.9
database_cross_reference: DO:DOID:12332
database_cross_reference: MSH:D006398
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:608.83
database_cross_reference: NDFRT:N0000001457
database_cross_reference: RCD:X400l
database_cross_reference: RCDAE:X400l
database_cross_reference: SNMI:D7-55185
database_cross_reference: SNOMEDCT_US:66259004

male genital organ stricture
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029767
Subclass_of: male reproductive system disease
Synonym: Male genital organ strict.NOS
Synonym: Male genital organ stricture
Synonym: Male genital organ stricture (disorder)
Synonym: Male genital organ stricture NOS
Synonym: Male genital organ stricture NOS (disorder)
Synonym: Stricture of male genital organs
Synonym: Stricture, male gen orgn
Tree Number: T10.8.1.3.8
database_cross_reference: DO:DOID:12333
database_cross_reference: ICD9CM:608.85
database_cross_reference: MDR:10042237
database_cross_reference: RCD:K288.
database_cross_reference: RCD:K288z
database_cross_reference: SNOMEDCT_US:198064007
database_cross_reference: SNOMEDCT_US:198067000

male genital organ vascular disease
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029776
Subclass_of: male reproductive system disease
Synonym: Male gen vascul dis NEC
Synonym: Male genital organ vasc.dis.
Synonym: Male genital organ vascular diseases
Synonym: Male genital organ vascular diseases (disorder)
Synonym: Vascular disorders of male genital organs
Synonym: disorder of male genital organs vascular
Synonym: vascular disorder of male genital organs
Synonym: vascular disorder of male genital organs (diagnosis)
Tree Number: T10.8.1.3.12
database_cross_reference: DO:DOID:12335
database_cross_reference: ICD10:N50.1
database_cross_reference: ICD10AM:N50.1
database_cross_reference: ICD10CM:N50.1
database_cross_reference: ICD9CM:608.83
database_cross_reference: MDR:10047070
database_cross_reference: MEDCIN:330824
database_cross_reference: RCD:K286.
database_cross_reference: SNOMEDCT_US:198057005

male infertility
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029759
Subclass_of: male reproductive system disease
Synonym: 7-56 MALE INFERTILITY DISORDERS
Synonym: INFERTILITY MALE
Synonym: Infertility male
Synonym: Infertility, Male
Synonym: Infertility, Male [Disease/Finding]
Synonym: Infertility, male
Synonym: Infertility;M
Synonym: MALE INFERTILITY DISORDERS
Synonym: Male Infertility
Synonym: Male infertility
Tree Number: T10.8.1.3.6
database_cross_reference: CHV:0000006701
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:FERTIL DEC MALE
database_cross_reference: DO:DOID:12336
database_cross_reference: HPO:HP:0003251
database_cross_reference: ICD10:N46
database_cross_reference: ICD10AM:N46
database_cross_reference: ICD10CM:N46
database_cross_reference: ICD10CM:N46.9
database_cross_reference: ICD9CM:606
database_cross_reference: ICD9CM:606.9
database_cross_reference: ICPC2P:Y10001
database_cross_reference: LCH:U002429
database_cross_reference: LCH_NW:sh85066092
database_cross_reference: MDR:10021929
database_cross_reference: MDR:10025511
database_cross_reference: MEDCIN:30445
database_cross_reference: MEDLINEPLUS:5656
database_cross_reference: MSH:D007248
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001686
database_cross_reference: OMIM:MTHU037362
database_cross_reference: RCD:K26..
database_cross_reference: RCD:K26z.
database_cross_reference: SNM:F-30720
database_cross_reference: SNMI:D7-56000
database_cross_reference: SNOMEDCT_US:155924001
database_cross_reference: SNOMEDCT_US:198018002
database_cross_reference: SNOMEDCT_US:2904007

gender identity disorder
type: Class
subclass of: disease of mental health
PMOID: PMO:00027933
Subclass_of: disease of mental health
Synonym: 9-14 GENDER IDENTITY DISORDERS
Synonym: Disorder;psychosexual identity
Synonym: Disorders of psychosexual identity
Synonym: GENDER IDENTITY DISORDERS
Synonym: Gender Identity Disorder
Synonym: Gender Role Disorders
Synonym: Gender identity disord unsp
Synonym: Gender identity disorder
Synonym: Gender identity disorder (disorder)
Synonym: Gender identity disorder NOS
Tree Number: T10.3.4
database_cross_reference: AOD:0000006811
database_cross_reference: CHV:0000005403
database_cross_reference: ICD10:F64
database_cross_reference: ICD10:F64.9
database_cross_reference: ICD10AM:F64
database_cross_reference: ICD10AM:F64.9
database_cross_reference: ICD10CM:F64
database_cross_reference: ICD10CM:F64.9
database_cross_reference: ICPC2P:P09002
database_cross_reference: MDR:10013350
database_cross_reference: MDR:10018054
database_cross_reference: MDR:10061976
database_cross_reference: MEDCIN:32811
database_cross_reference: MEDCIN:351431
database_cross_reference: MTHICD9:302.6
database_cross_reference: NCI:C94362
database_cross_reference: PSY:20719
database_cross_reference: RCD:E226.
database_cross_reference: RCD:E226z
database_cross_reference: RCD:Eu64.
database_cross_reference: RCD:Eu64z
database_cross_reference: RCD:X00TG
database_cross_reference: RCDSY:Eu64.
database_cross_reference: RCDSY:Eu64z
database_cross_reference: SNM:D-9600
database_cross_reference: SNM:F-96090
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D9-14000
database_cross_reference: SNOMEDCT_US:191787001
database_cross_reference: SNOMEDCT_US:191790007
database_cross_reference: SNOMEDCT_US:192507000
database_cross_reference: SNOMEDCT_US:192511006
database_cross_reference: SNOMEDCT_US:87991007

fetishism
type: Class
subclass of: paraphilia disorder
PMOID: PMO:00028151
Subclass_of: paraphilia disorder
Synonym: FETISHISM
Synonym: Fetish
Synonym: Fetishism
Synonym: Fetishism (Psychiatric)
Synonym: Fetishism (Psychiatric) [Disease/Finding]
Synonym: Fetishism (disorder)
Synonym: Fetishisms (Psychiatric)
Synonym: Fetishistic disorder
Synonym: Fetishistic disorder (diagnosis)
Synonym: Sexual Fetishism
Tree Number: T10.3.11.2.1
database_cross_reference: AOD:0000006803
database_cross_reference: CHV:0000005004
database_cross_reference: CHV:0000050770
database_cross_reference: DO:DOID:1235
database_cross_reference: DSM-5:302.81
database_cross_reference: DSM-5:F65.0
database_cross_reference: ICD10:F65.0
database_cross_reference: ICD10AM:F65.0
database_cross_reference: ICD10CM:F65.0
database_cross_reference: ICD9CM:302.81
database_cross_reference: ICPC2P:P09004
database_cross_reference: MDR:10016530
database_cross_reference: MDR:10016531
database_cross_reference: MEDCIN:32812
database_cross_reference: MSH:D005329
database_cross_reference: NCI:C94353
database_cross_reference: NDFRT:N0000001239
database_cross_reference: PSY:19640
database_cross_reference: PSY:47040
database_cross_reference: RCD:E22y0
database_cross_reference: SNM:F-99600
database_cross_reference: SNMI:D9-73170
database_cross_reference: SNOMEDCT_US:192513009
database_cross_reference: SNOMEDCT_US:59174009

malaria
type: Class
subclass of: parasitic protozoa infectious disease
PMOID: PMO:00029704
Subclass_of: parasitic protozoa infectious disease
Synonym: Malaria
Synonym: Malaria Pathway
Synonym: Plasmodium Infection Pathway
Synonym: Plasmodium sp. Infection Pathway
Tree Number: T10.7.4.2.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91807
database_cross_reference: NCI_KEGG:C91807

prolapse of urethra
type: Class
subclass of: urethral disease
definition: A prolapse of female genital organ that is characterized by the descent of the urethra from the normal anatomic location toward or through the vaginal opening.
PMOID: PMO:00029835
Subclass_of: urethral disease
Synonym: Prolapse of urethra
Synonym: Prolapse of urethra (disorder)
Synonym: Prolapse;urethral
Synonym: URETHRA, PROLAPSE
Synonym: URETHROCELE
Synonym: Urethral Prolapse
Synonym: Urethral prolapse
Synonym: Urethrocele
Synonym: prolapse urethra
Synonym: prolapse urethral
Tree Number: T10.8.7.3.6
database_cross_reference: CCPSS:1003259
database_cross_reference: CHV:0000024047
database_cross_reference: COSTAR:U000598
database_cross_reference: DO:DOID:12369
database_cross_reference: DXP:U001963
database_cross_reference: DXP:U004236
database_cross_reference: HPO:HP:0100821
database_cross_reference: ICD10CM:N81.0
database_cross_reference: ICD9CM:618.03
database_cross_reference: ICPC2P:U99009
database_cross_reference: MDR:10067784
database_cross_reference: MEDCIN:261937
database_cross_reference: MEDCIN:34193
database_cross_reference: MEDCIN:35767
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:599.5
database_cross_reference: NCI:C123256
database_cross_reference: NCI_NICHD:C123256
database_cross_reference: RCD:X408H
database_cross_reference: SNM:M-31050
database_cross_reference: SNM:M-31650
database_cross_reference: SNMI:D7-23570
database_cross_reference: SNOMEDCT_US:12068006
database_cross_reference: SNOMEDCT_US:197935003
database_cross_reference: SNOMEDCT_VET:12068006

shigellosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.
PMOID: PMO:00029576
Subclass_of: primary bacterial infectious disease
Synonym: Dysenteries, Shigella
Synonym: Dysentery, Shigella
Synonym: E-140 SHIGELLOSES
Synonym: Flexner's dysentery
Synonym: GASTROENTERITIS SHIGELLA
Synonym: Gastroenteritis shigella
Synonym: Infection by Shigella
Synonym: Infection by Shigella (disorder)
Synonym: Infection caused by Shigella
Synonym: Infection caused by Shigella (disorder)
Tree Number: T10.7.3.1.32
database_cross_reference: CCPSS:0009227
database_cross_reference: CCPSS:0037431
database_cross_reference: CHV:0000004205
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1248-4621
database_cross_reference: DO:DOID:12385
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001735
database_cross_reference: ICD10:A03
database_cross_reference: ICD10:A03.9
database_cross_reference: ICD10AM:A03
database_cross_reference: ICD10AM:A03.9
database_cross_reference: ICD10CM:A03
database_cross_reference: ICD10CM:A03.9
database_cross_reference: ICD9CM:004
database_cross_reference: ICD9CM:004.9
database_cross_reference: ICPC2P:D70021
database_cross_reference: LCH_NW:sh85121416
database_cross_reference: LNC:LA10505-8
database_cross_reference: MDR:10017915
database_cross_reference: MDR:10040549
database_cross_reference: MDR:10040550
database_cross_reference: MDR:10040553
database_cross_reference: MDR:10040554
database_cross_reference: MDR:10054178
database_cross_reference: MEDCIN:31130
database_cross_reference: MSH:D004405
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:A03..
database_cross_reference: RCD:A03z.
database_cross_reference: RCD:Ayu05
database_cross_reference: RCDSY:Ayu05
database_cross_reference: SNM:D-0176
database_cross_reference: SNMI:DE-14000
database_cross_reference: SNOMEDCT_US:111817006
database_cross_reference: SNOMEDCT_US:154272001
database_cross_reference: SNOMEDCT_US:186108001
database_cross_reference: SNOMEDCT_US:187272003
database_cross_reference: SNOMEDCT_US:266175007
database_cross_reference: SNOMEDCT_US:36188001

balantidiasis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease involving infection caused by Balantidium coli. The trophozoites are capable of attacking the intestinal epithelium, creating ulcers and causing bloody diarrhea. The infectiou has_symptom cramping, has_symptom abdominal pain, has_symptom nausea and has_symptom foul breath.
PMOID: PMO:00029698
Subclass_of: parasitic protozoa infectious disease
Tree Number: T10.7.4.2.10
database_cross_reference: DO:DOID:12386

neurohypophyseal diabetes insipidus
type: Class
subclass of: pancreas disease
PMOID: PMO:00033203
Subclass_of: pancreas disease
Synonym: Antidiuretic hormone deficiency
Synonym: CDI
Synonym: Central Diabetes Insipidus
Synonym: Central diabetes insipidus
Synonym: Central diabetes insipidus (disorder)
Synonym: Central diabetes insipidus [Ambiguous]
Synonym: Cranial diabetes insipidus
Synonym: DIABETES INSIPIDUS, CRANIAL TYPE
Synonym: DIABETES INSIPIDUS, NEUROHYPOPHYSEAL
Synonym: DIABETES INSIPIDUS, NEUROHYPOPHYSEAL TYPE
Tree Number: T10.8.8.4.7
database_cross_reference: CHV:0000044128
database_cross_reference: CSP:1849-2602
database_cross_reference: DO:DOID:12388
database_cross_reference: DXP:U000469
database_cross_reference: HPO:HP:0000863
database_cross_reference: MDR:10049518
database_cross_reference: MDR:10068587
database_cross_reference: MDR:10073192
database_cross_reference: MDR:10078568
database_cross_reference: MEDCIN:30492
database_cross_reference: MSH:D020790
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:253.5
database_cross_reference: NCI:C84933
database_cross_reference: NCI_NICHD:C84933
database_cross_reference: NDFRT:N0000004189
database_cross_reference: OMIM:125700
database_cross_reference: OMIM:192340
database_cross_reference: OMIM:304900
database_cross_reference: OMIM:MTHU004824
database_cross_reference: OMIM:MTHU054071
database_cross_reference: RCD:XE10Y
database_cross_reference: SNM:D-2103
database_cross_reference: SNMI:DB-13110
database_cross_reference: SNMI:DB-13144
database_cross_reference: SNOMEDCT_US:154699008
database_cross_reference: SNOMEDCT_US:15771004
database_cross_reference: SNOMEDCT_US:190484000
database_cross_reference: SNOMEDCT_US:267393007
database_cross_reference: SNOMEDCT_US:45369008
database_cross_reference: SNOMEDCT_US:64410003

pathological gambling
type: Class
subclass of: impulse control disorder
definition: An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life.
PMOID: PMO:00028133
Subclass_of: impulse control disorder
Synonym: Compulsive Gambling
Synonym: Compulsive gambling
Synonym: Compulsive gambling (disorder)
Synonym: Compulsive gambling (finding)
Synonym: GAMBLING PATHOL
Synonym: GAMBLING, PATHOLOGIC
Synonym: Gambling addiction
Synonym: Gambling disorder
Synonym: Gambling pathological
Synonym: Gambling, Pathologic
Tree Number: T10.3.7.1
database_cross_reference: AOD:0000006711
database_cross_reference: CHV:0000009353
database_cross_reference: CHV:0000050764
database_cross_reference: DO:DOID:12399
database_cross_reference: DSM-5:312.31
database_cross_reference: DSM-5:F63.0
database_cross_reference: ICD10:F63.0
database_cross_reference: ICD10AM:F63.0
database_cross_reference: ICD10CM:F63.0
database_cross_reference: ICD9CM:312.31
database_cross_reference: MDR:10017656
database_cross_reference: MDR:10017657
database_cross_reference: MDR:10034158
database_cross_reference: MDR:10078070
database_cross_reference: MEDCIN:32832
database_cross_reference: MEDLINEPLUS:4308
database_cross_reference: MSH:D005715
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94335
database_cross_reference: OMIM:606349
database_cross_reference: PSY:10855
database_cross_reference: PSY:36905
database_cross_reference: RCD:E2C31
database_cross_reference: RCD:Xa2ke
database_cross_reference: SNM:F-91570
database_cross_reference: SNMI:D9-75030
database_cross_reference: SNOMEDCT_US:18085000
database_cross_reference: SNOMEDCT_US:192501004
database_cross_reference: SNOMEDCT_US:284524008

kleptomania
type: Class
subclass of: impulse control disorder
definition: An impulse control disorder that involves the repeated impulse to steal for no great gain, when he or she has sufficient money to pay for the item and no need for what is stolen.
PMOID: PMO:00028136
Subclass_of: impulse control disorder
Synonym: Kleptomania
Synonym: Kleptomania (disorder)
Synonym: Kleptomannia
Synonym: Pathological stealing
Synonym: Pathological stealing (disorder)
Synonym: Pathological stealing [kleptomania]
Synonym: kleptomania (diagnosis)
Tree Number: T10.3.7.4
database_cross_reference: AOD:0000006707
database_cross_reference: CHV:0000007120
database_cross_reference: DO:DOID:12400
database_cross_reference: DSM-5:312.32
database_cross_reference: DSM-5:F63.2
database_cross_reference: ICD10:F63.2
database_cross_reference: ICD10AM:F63.2
database_cross_reference: ICD10CM:F63.2
database_cross_reference: ICD9CM:312.32
database_cross_reference: MDR:10023461
database_cross_reference: MDR:10023462
database_cross_reference: MEDCIN:32833
database_cross_reference: MSH:D007174
database_cross_reference: NCI:C94333
database_cross_reference: OMIM:MTHU050979
database_cross_reference: PSY:27420
database_cross_reference: RCD:E2C32
database_cross_reference: SNM:F-91440
database_cross_reference: SNMI:D9-75020
database_cross_reference: SNOMEDCT_US:154947009
database_cross_reference: SNOMEDCT_US:192503001
database_cross_reference: SNOMEDCT_US:69361009

intermittent explosive disorder
type: Class
subclass of: impulse control disorder
definition: An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.
PMOID: PMO:00028138
Subclass_of: impulse control disorder
Synonym: Disorders, Intermittent Explosive
Synonym: Explosive Disorder, Intermittent
Synonym: INTERMITTENT EXPLOSIVE DIS
Synonym: Intermitt explosive dis
Synonym: Intermittent Explosive Disorder
Synonym: Intermittent Explosive Disorders
Synonym: Intermittent explosive disord.
Synonym: Intermittent explosive disorder
Synonym: Intermittent explosive disorder (disorder)
Synonym: explosive intermittent disorder
Tree Number: T10.3.7.6
database_cross_reference: AOD:0000006706
database_cross_reference: CHV:0000006832
database_cross_reference: DO:DOID:12401
database_cross_reference: DSM-5:312.34
database_cross_reference: DSM-5:F63.81
database_cross_reference: ICD10CM:F63.81
database_cross_reference: ICD9CM:312.34
database_cross_reference: MDR:10022568
database_cross_reference: MEDCIN:32835
database_cross_reference: MSH:D007174
database_cross_reference: NCI:C94332
database_cross_reference: PSY:26135
database_cross_reference: RCD:E2C34
database_cross_reference: SNMI:D9-75010
database_cross_reference: SNOMEDCT_US:192096007
database_cross_reference: SNOMEDCT_US:40987004

pyromania
type: Class
subclass of: impulse control disorder
definition: An impulse control disorder that involves the uncontrollable impulse to repeatedly set fires with no obvious motive.
PMOID: PMO:00028134
Subclass_of: impulse control disorder
Synonym: Behavior, Firesetting
Synonym: Behaviors, Firesetting
Synonym: Firesetting
Synonym: Firesetting (finding)
Synonym: Firesetting Behavior
Synonym: Firesetting Behavior [Disease/Finding]
Synonym: Firesetting Behaviors
Synonym: Firesetting behavior
Synonym: Firesetting behaviour
Synonym: PYROMANIA
Tree Number: T10.3.7.2
database_cross_reference: AOD:0000006708
database_cross_reference: CHV:0000005061
database_cross_reference: CHV:0000039188
database_cross_reference: CST:INJURY INTENT
database_cross_reference: DO:DOID:12402
database_cross_reference: DSM-5:312.33
database_cross_reference: DSM-5:F63.1
database_cross_reference: ICD10:F63.1
database_cross_reference: ICD10AM:F63.1
database_cross_reference: ICD10CM:F63.1
database_cross_reference: ICD9CM:312.33
database_cross_reference: LCH_NW:sh85109348
database_cross_reference: MDR:10037674
database_cross_reference: MDR:10040440
database_cross_reference: MEDCIN:1356
database_cross_reference: MEDCIN:32834
database_cross_reference: MSH:D005391
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94334
database_cross_reference: NDFRT:N0000001256
database_cross_reference: PSY:19857
database_cross_reference: PSY:42430
database_cross_reference: RCD:E2C33
database_cross_reference: RCD:X765T
database_cross_reference: SNM:F-91480
database_cross_reference: SNMI:D9-75040
database_cross_reference: SNOMEDCT_US:192502006
database_cross_reference: SNOMEDCT_US:248015004
database_cross_reference: SNOMEDCT_US:600009

thyrocalcitonin secretion disease
type: Class
subclass of: thyroid gland disease
PMOID: PMO:00033182
Subclass_of: thyroid gland disease
Synonym: Calcitonin secretion disorder
Synonym: Dis thyrocalciton secret
Synonym: Disord thyrocalcitonin secretn
Synonym: Disorder of thyrocalcitonin secretion
Synonym: Disorder of thyrocalcitonin secretion (disorder)
Synonym: Disorders of thyrocalcitonin secretion
Synonym: disorder of thyrocalcitonin secretion
Tree Number: T10.8.8.3.6
database_cross_reference: DO:DOID:12424
database_cross_reference: ICD9CM:246.0
database_cross_reference: MDR:10006946
database_cross_reference: MDR:10013370
database_cross_reference: RCD:C060.
database_cross_reference: SNOMEDCT_US:190303007

aplastic anemia
type: Class
subclass of: anemia
definition: An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.
PMOID: PMO:00033327
Subclass_of: anemia
Synonym: ANAEMIA APLASTIC
Synonym: ANEMIA APLASTIC
Synonym: ANEMIA, APLASTIC
Synonym: APLASTIC ANEMIA
Synonym: Anaemia - aplastic
Synonym: Anaemia aplastic
Synonym: Anaemia;aplastic
Synonym: Anemia - aplastic
Synonym: Anemia aplastic
Synonym: Anemia, Aplastic
Tree Number: T10.8.10.4.2
database_cross_reference: AOD:0000005879
database_cross_reference: CCPSS:0017909
database_cross_reference: CHV:0000001120
database_cross_reference: COSTAR:U000044
database_cross_reference: CSP:0427-0486
database_cross_reference: CST:ANEMIA APLAST
database_cross_reference: DO:DOID:12449
database_cross_reference: DXP:U000088
database_cross_reference: HPO:HP:0001915
database_cross_reference: ICD10:D61.9
database_cross_reference: ICD10AM:D61.9
database_cross_reference: ICD10AMAE:D61.9
database_cross_reference: ICD10CM:D61.9
database_cross_reference: ICD9CM:284.9
database_cross_reference: ICPC2P:B82001
database_cross_reference: LCH_NW:sh85005993
database_cross_reference: MDR:10002037
database_cross_reference: MDR:10002274
database_cross_reference: MDR:10002967
database_cross_reference: MDR:10002968
database_cross_reference: MDR:10002969
database_cross_reference: MDR:10002970
database_cross_reference: MEDCIN:30332
database_cross_reference: MEDLINEPLUS:5955
database_cross_reference: MSH:D000741
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:284.9
database_cross_reference: NCI:C2870
database_cross_reference: NCI_NCI-GLOSS:CDR0000045479
database_cross_reference: NCI_NICHD:C2870
database_cross_reference: NDFRT:N0000000385
database_cross_reference: OMIM:170280
database_cross_reference: OMIM:602667
database_cross_reference: OMIM:609135
database_cross_reference: OMIM:MTHU009662
database_cross_reference: PDQ:CDR0000489004
database_cross_reference: RCD:D20..
database_cross_reference: RCD:D20z.
database_cross_reference: RCDAE:D20..
database_cross_reference: RCDAE:D20z.
database_cross_reference: SNM:D-4031
database_cross_reference: SNM:M-75400
database_cross_reference: SNMI:DC-11010
database_cross_reference: SNOMEDCT_US:154807001
database_cross_reference: SNOMEDCT_US:191233006
database_cross_reference: SNOMEDCT_US:191258001
database_cross_reference: SNOMEDCT_US:267560004
database_cross_reference: SNOMEDCT_US:304132006
database_cross_reference: SNOMEDCT_US:305047005
database_cross_reference: SNOMEDCT_US:306058006
database_cross_reference: SNOMEDCT_US:79000000

pancytopenia
type: Class
subclass of: anemia
definition: An anemia that is characterized by a reduction in the number of red blood cells, white blood cells, and platelets.
PMOID: PMO:00033368
Subclass_of: anemia
Synonym: Bone Marrow Failure
Synonym: Bone marrow failure
Synonym: Low blood cell count
Synonym: PANCYTOPENIA
Synonym: Pancytopenia
Synonym: Pancytopenia (disorder)
Synonym: Pancytopenia (finding)
Synonym: Pancytopenia NOS
Synonym: Pancytopenia NOS (disorder)
Synonym: Pancytopenia [Disease/Finding]
Tree Number: T10.8.10.4.6
database_cross_reference: AOD:0000005869
database_cross_reference: BI:BI00324
database_cross_reference: CCPSS:1016106
database_cross_reference: CHV:0000009232
database_cross_reference: COSTAR:U000504
database_cross_reference: CST:PANCYTOPENIA
database_cross_reference: DO:DOID:12450
database_cross_reference: DXP:U003004
database_cross_reference: HPO:HP:0001876
database_cross_reference: ICD10CM:D61.81
database_cross_reference: ICD9CM:284.1
database_cross_reference: MDR:10033661
database_cross_reference: MEDCIN:30299
database_cross_reference: MSH:D010198
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34889
database_cross_reference: NCI:C80693
database_cross_reference: NCI_NICHD:C34889
database_cross_reference: NDFRT:N0000002291
database_cross_reference: OMIM:MTHU036683
database_cross_reference: RCD:X20CN
database_cross_reference: RCD:XE13v
database_cross_reference: SNM:M-59120
database_cross_reference: SNOMEDCT_US:127034005
database_cross_reference: SNOMEDCT_US:191250008
database_cross_reference: SNOMEDCT_US:267528007
database_cross_reference: SNOMEDCT_VET:312511000009109

sulfhemoglobinemia
type: Class
subclass of: blood protein disease
PMOID: PMO:00033323
Subclass_of: blood protein disease
Synonym: SULFHAEMOGLOBINAEMIA
Synonym: SULFHEMOGLOBINEMIA
Synonym: Sulfemoglobinemia
Synonym: Sulfhaemoglobinaemia
Synonym: Sulfhemoglobinemia
Synonym: Sulfhemoglobinemia (disorder)
Synonym: Sulfhemoglobinemia [Disease/Finding]
Synonym: Sulfhemoglobinemia [dup] (disorder)
Synonym: Sulfhemoglobinemias
Synonym: Sulphaemoglobinaemia
Tree Number: T10.8.10.2.2
database_cross_reference: CST:SULFHEMOGLOBIN
database_cross_reference: DO:DOID:12451
database_cross_reference: DXP:U003882
database_cross_reference: MDR:10042480
database_cross_reference: MDR:10042481
database_cross_reference: MDR:10042490
database_cross_reference: MDR:10054653
database_cross_reference: MDR:10055636
database_cross_reference: MEDCIN:30374
database_cross_reference: MSH:D013436
database_cross_reference: MTHICD9:289.7
database_cross_reference: NDFRT:N0000002857
database_cross_reference: RCD:D4174
database_cross_reference: SNM:D-4310
database_cross_reference: SNMI:DC-20520
database_cross_reference: SNOMEDCT_US:191386007
database_cross_reference: SNOMEDCT_US:191391008
database_cross_reference: SNOMEDCT_US:32117000

blood coagulation disease
type: Class
subclass of: hematopoietic system disease
PMOID: PMO:00033259
Subclass_of: hematopoietic system disease
Synonym: (Coagulation defects) or (bleeding disorders)
Synonym: (Coagulation defects) or (bleeding disorders) (disorder)
Synonym: Abnormal;coagulation
Synonym: Abnormality of the coagulation cascade
Synonym: BLOOD COAG DIS
Synonym: BLOOD COAGULATION DEFECT
Synonym: BLOOD COAGULATION DISORDER
Synonym: Blood Coagulation Disorder
Synonym: Blood Coagulation Disorders
Synonym: Blood Coagulation Disorders [Disease/Finding]
Tree Number: T10.8.10.1
database_cross_reference: AOD:0000005928
database_cross_reference: AOD:0000005929
database_cross_reference: CCPSS:0027739
database_cross_reference: CHV:0000001990
database_cross_reference: COSTAR:188
database_cross_reference: COSTAR:U000185
database_cross_reference: CSP:0438-1873
database_cross_reference: CST:COAGUL DIS
database_cross_reference: CST:HAL/COAG
database_cross_reference: DO:DOID:1247
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000386
database_cross_reference: HPO:HP:0001928
database_cross_reference: HPO:HP:0003256
database_cross_reference: ICD10:D68.9
database_cross_reference: ICD10AM:D68.9
database_cross_reference: ICD10CM:D68.9
database_cross_reference: ICD9CM:286
database_cross_reference: ICPC2P:B83001
database_cross_reference: LCH:U006363
database_cross_reference: LCH_NW:sh85014937
database_cross_reference: MDR:10009727
database_cross_reference: MDR:10009729
database_cross_reference: MDR:10009731
database_cross_reference: MDR:10009734
database_cross_reference: MDR:10009802
database_cross_reference: MDR:10012116
database_cross_reference: MDR:10013206
database_cross_reference: MDR:10048498
database_cross_reference: MDR:10053567
database_cross_reference: MDR:10064732
database_cross_reference: MEDCIN:35838
database_cross_reference: MEDLINEPLUS:166
database_cross_reference: MEDLINEPLUS:3115
database_cross_reference: MSH:D001778
database_cross_reference: MTH:188
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:286.9
database_cross_reference: NCI:C2902
database_cross_reference: NCI_FDA:1779
database_cross_reference: NCI_NICHD:C2902
database_cross_reference: NDFRT:N0000000575
database_cross_reference: OMIM:MTHU008649
database_cross_reference: OMIM:MTHU033936
database_cross_reference: RCD:D30..
database_cross_reference: RCD:D30z.
database_cross_reference: SNM:D-4400
database_cross_reference: SNM:F-54302
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DC-60000
database_cross_reference: SNOMEDCT_US:127073005
database_cross_reference: SNOMEDCT_US:154815003
database_cross_reference: SNOMEDCT_US:191303002
database_cross_reference: SNOMEDCT_US:267562007
database_cross_reference: SNOMEDCT_US:362970003
database_cross_reference: SNOMEDCT_US:64779008

capillariasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the intestine, liver and lungs caused by Capillaria species.
PMOID: PMO:00029644
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Capillaria infection
Tree Number: T10.7.4.1.22
database_cross_reference: DO:DOID:12474

trichuriasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.
PMOID: PMO:00029649
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Trichuris trichura
Synonym: Trichuriasis infection
Synonym: Whipworm disease
Synonym: trichuris trichiura infection
Tree Number: T10.7.4.1.27
database_cross_reference: DO:DOID:1252

hepatitis A
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.
PMOID: PMO:00029373
Subclass_of: viral infectious disease
Synonym: HAV
Synonym: HEPATITIS A
Synonym: HEPATITIS INFECT
Synonym: HEPATITIS INFECTIOUS
Synonym: HEPATITIS, INFECTIOUS
Synonym: Hep A
Synonym: Hepatitides, Infectious
Synonym: Hepatitis A
Synonym: Hepatitis A Infection
Synonym: Hepatitis A [Disease/Finding]
Tree Number: T10.7.2.23
database_cross_reference: AOD:0000004802
database_cross_reference: AOD:0000023162
database_cross_reference: BI:BI00260
database_cross_reference: CCPSS:0046284
database_cross_reference: CCPSS:1017953
database_cross_reference: CHV:0000006044
database_cross_reference: CHV:0000044720
database_cross_reference: CHV:0000050591
database_cross_reference: CHV:0000055094
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000344
database_cross_reference: CSP:1754-6980
database_cross_reference: CSP:4000-0219
database_cross_reference: CST:HEPATITIS
database_cross_reference: DO:DOID:12549
database_cross_reference: DXP:NOCODE
database_cross_reference: ICPC2P:D72001
database_cross_reference: ICPC2P:D72006
database_cross_reference: LCH:U002171
database_cross_reference: LCH_NW:sh85060293
database_cross_reference: MDR:10019618
database_cross_reference: MDR:10019719
database_cross_reference: MDR:10019780
database_cross_reference: MDR:10019782
database_cross_reference: MDR:10021913
database_cross_reference: MDR:10047447
database_cross_reference: MEDCIN:30152
database_cross_reference: MEDLINEPLUS:1686
database_cross_reference: MSH:D006506
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:070.1
database_cross_reference: NCI:C3096
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NICHD:C3096
database_cross_reference: NDFRT:N0000001500
database_cross_reference: RCD:XE0TW
database_cross_reference: SNM:D-0521
database_cross_reference: SNMI:DE-35100
database_cross_reference: SNOMEDCT_US:154347003
database_cross_reference: SNOMEDCT_US:40468003

trichostrongyloidiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by nematodes of the superfamily Trichostrongyloidea.
PMOID: PMO:00029659
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Trichostrongyloidiases
Synonym: Trichostrongyloidiasis
Synonym: Trichostrongyloidiasis [Disease/Finding]
Tree Number: T10.7.4.1.30
database_cross_reference: DO:DOID:1255
database_cross_reference: MSH:D014252
database_cross_reference: NDFRT:N0000003011

hemolytic-uremic syndrome
type: Class
subclass of: kidney disease
definition: A kidney disease that is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs.
PMOID: PMO:00032988
Subclass_of: kidney disease
Synonym: GASSER SYNDROME
Synonym: Gasser Syndrome
Synonym: Gasser's Syndrome
Synonym: Gasser's syndrome
Synonym: Gassers Syndrome
Synonym: HEMOLYTIC UREMIC SYNDROME
Synonym: HEMOLYTIC-UREMIC SYNDROME
Synonym: HUS
Synonym: HUS (hemolytic uremic syndrome)
Synonym: HUS - Haemoly uraemic syndrome
Tree Number: T10.8.7.9.4
database_cross_reference: CCPSS:1006075
database_cross_reference: CHV:0000006001
database_cross_reference: CSP:0427-1005
database_cross_reference: CSP:1682-2744
database_cross_reference: CST:UREMIA
database_cross_reference: DO:DOID:12554
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000799
database_cross_reference: HPO:HP:0005575
database_cross_reference: ICD10:D59.3
database_cross_reference: ICD10AM:D59.3
database_cross_reference: ICD10AMAE:D59.3
database_cross_reference: ICD10CM:D59.3
database_cross_reference: ICD9CM:283.11
database_cross_reference: LCH:U002153
database_cross_reference: LCH_NW:sh85060213
database_cross_reference: MDR:10018932
database_cross_reference: MDR:10018933
database_cross_reference: MDR:10019515
database_cross_reference: MDR:10019516
database_cross_reference: MDR:10020472
database_cross_reference: MDR:10042814
database_cross_reference: MDR:10060422
database_cross_reference: MEDCIN:30349
database_cross_reference: MSH:D006463
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75545
database_cross_reference: NCI_CTCAE:E10043
database_cross_reference: NCI_NICHD:C75545
database_cross_reference: NDFRT:N0000001476
database_cross_reference: OMIM:MTHU037996
database_cross_reference: RCD:D1113
database_cross_reference: RCDAE:D1113
database_cross_reference: SNM:D-4294
database_cross_reference: SNMI:D7-13100
database_cross_reference: SNOMEDCT_US:111407006
database_cross_reference: SNOMEDCT_US:123308008

urethral obstruction
type: Class
subclass of: urethral disease
PMOID: PMO:00032962
Subclass_of: urethral disease
Synonym: Obstruction of urethra
Synonym: Obstruction of urethra (disorder)
Synonym: Obstruction of urethra, NOS
Synonym: Obstruction, Urethral
Synonym: Obstructions, Urethral
Synonym: URETHRAL OBSTRUCTION
Synonym: Urethral Obstruction
Synonym: Urethral Obstruction [Disease/Finding]
Synonym: Urethral Obstructions
Synonym: Urethral obstruction
Tree Number: T10.8.7.3.3
database_cross_reference: CHV:0000012769
database_cross_reference: DO:DOID:12577
database_cross_reference: DXP:U004233
database_cross_reference: HPO:HP:0000796
database_cross_reference: MDR:10046459
database_cross_reference: MEDCIN:35770
database_cross_reference: MSH:D014524
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C79804
database_cross_reference: NDFRT:N0000003074
database_cross_reference: OMIM:MTHU037522
database_cross_reference: SNMI:D7-23380
database_cross_reference: SNOMEDCT_US:95588004

Cri-Du-Chat syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028789
Subclass_of: chromosomal deletion syndrome
Synonym: 5p deletion syndrome
Synonym: 5p partial monosomy syndrome
Synonym: Cri-du-chat syndrome
Synonym: chromosome 5 short arm deletion syndrome
Synonym: chromosome 5p deletion syndrome
Tree Number: T10.5.9.8.12
database_cross_reference: DO:DOID:12580

velocardiofacial syndrome
type: Class
subclass of: chromosomal deletion syndrome
definition: A T cell deficiency disease that is the result of a large deletion of chromosome 22 which includes the DGS gene needed for development of the thymus and related glands with subsequent lack of T-cell production.
PMOID: PMO:00028795
Subclass_of: chromosomal deletion syndrome
Synonym: 22q11.2 Deletion Syndrome
Synonym: 3rd+4th pharyngeal pouch syndr
Synonym: Agenesis of the parathyroid AND thymus glands
Synonym: Agenesis of the parathyroid and thymus glands
Synonym: Autosomal Dominant Opitz G Bbb Syndrome
Synonym: Autosomal Dominant Opitz G-Bbb Syndrome
Synonym: Branchial arch syndrome
Synonym: CATCH22
Synonym: CHROMOSOME 22q11.2 DELETION SYNDROME
Synonym: Catch22
Tree Number: T10.5.9.8.18
database_cross_reference: CHV:0000003934
database_cross_reference: CSP:0427-9991
database_cross_reference: DO:DOID:11198
database_cross_reference: DRUGBANK:DB06804
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:D82.1
database_cross_reference: ICD10AM:D82.1
database_cross_reference: ICD10CM:D82.1
database_cross_reference: ICD9CM:279.11
database_cross_reference: JABL:268
database_cross_reference: JABL:73
database_cross_reference: MDR:10012979
database_cross_reference: MDR:10043664
database_cross_reference: MEDCIN:362065
database_cross_reference: MSH:D004062
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:279.11
database_cross_reference: NCI:C2989
database_cross_reference: NCI_NICHD:C2989
database_cross_reference: NDFRT:N0000000971
database_cross_reference: OMIM:188400
database_cross_reference: OMIM:602054
database_cross_reference: RCD:C3911
database_cross_reference: SNM:D-4607
database_cross_reference: SNMI:D4-01532
database_cross_reference: SNOMEDCT_US:190991007
database_cross_reference: SNOMEDCT_US:77128003

hiatus hernia
type: Class
subclass of: stomach disease
PMOID: PMO:00033461
Subclass_of: stomach disease
Synonym: Diaphragmatic - hiatus -hernia
Synonym: Gastresophageal hernia
Synonym: Gastroesophageal hernia
Synonym: Gastrooesophageal hernia
Synonym: Hernia, Paraesophageal
Synonym: Hernia, Paraesophageal Hiatal
Synonym: Hernia, gastroesophageal
Synonym: Hernias, Paraesophageal
Synonym: Hernias, Paraesophageal Hiatal
Synonym: Hiatal Hernia, Paraesophageal
Tree Number: T10.8.11.3.5
database_cross_reference: AOD:0000005698
database_cross_reference: AOD:0000023416
database_cross_reference: CHV:0000026202
database_cross_reference: DO:DOID:12642
database_cross_reference: ICD10CM:K44
database_cross_reference: MDR:10033774
database_cross_reference: MDR:10033884
database_cross_reference: MDR:10039210
database_cross_reference: MDR:10059188
database_cross_reference: MDR:10072765
database_cross_reference: MEDCIN:276110
database_cross_reference: MEDCIN:30144
database_cross_reference: MSH:D006551
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU038976
database_cross_reference: RCD:X30BC
database_cross_reference: RCDAE:X30BC
database_cross_reference: SNM:M-31650
database_cross_reference: SNMI:D5-60604
database_cross_reference: SNOMEDCT_US:3662000

nephrocalcinosis
type: Class
subclass of: kidney disease
PMOID: PMO:00028941
Subclass_of: kidney disease
Synonym: CALCINOSIS RENAL
Synonym: Calcinosis renal
Synonym: NEPHROCALCINOSIS
Synonym: Nephrocalcinoses
Synonym: Nephrocalcinosis
Synonym: Nephrocalcinosis (disorder)
Synonym: Nephrocalcinosis [Disease/Finding]
Synonym: Renal calcification
Synonym: nephrocalcinosis (diagnosis)
Tree Number: T10.8.7.9.24
database_cross_reference: AOD:0000005778
database_cross_reference: CCPSS:1008995
database_cross_reference: CHV:0000008582
database_cross_reference: COSTAR:U000471
database_cross_reference: CSP:1682-1409
database_cross_reference: CST:NEPHROCALCINOSIS
database_cross_reference: DO:DOID:12679
database_cross_reference: DXP:U001268
database_cross_reference: DXP:U002787
database_cross_reference: HPO:HP:0000121
database_cross_reference: MDR:10006939
database_cross_reference: MDR:10029146
database_cross_reference: MEDCIN:273193
database_cross_reference: MSH:D009397
database_cross_reference: MTHICD9:275.49
database_cross_reference: NCI:C84918
database_cross_reference: NCI_NICHD:C84918
database_cross_reference: NDFRT:N0000002151
database_cross_reference: OMIM:MTHU005829
database_cross_reference: RCD:C3547
database_cross_reference: SNM:M-55500
database_cross_reference: SNMI:D6-34732
database_cross_reference: SNOMEDCT_US:154752005
database_cross_reference: SNOMEDCT_US:190863003
database_cross_reference: SNOMEDCT_US:267505006
database_cross_reference: SNOMEDCT_US:48638002
database_cross_reference: SNOMEDCT_VET:48638002

locked-in syndrome
type: Class
subclass of: nervous system disease
definition: A nervous system disease that is characterized by complete paralysis of all voluntary muscles except for the ones that control the movements of the eyes.
PMOID: PMO:00030717
Subclass_of: nervous system disease
Synonym: 'Locked in' syndrome
Synonym: CEREBROMEDULLOSPINAL DISCONNECTION
Synonym: Cerebromedullary disconnection syndrome
Synonym: DE-EFFERENTED STATE
Synonym: LOCKED-IN SYNDROME
Synonym: Locked In Syndrome
Synonym: Locked in syndrome
Synonym: Locked in syndrome (disorder)
Synonym: Locked-In Syndrome
Synonym: Locked-In Syndromes
Tree Number: T10.8.2.10
database_cross_reference: CHV:0000007521
database_cross_reference: DO:DOID:12697
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001083
database_cross_reference: ICD10CM:G83.5
database_cross_reference: ICD9CM:344.81
database_cross_reference: MDR:10024791
database_cross_reference: MDR:10024792
database_cross_reference: MEDCIN:32203
database_cross_reference: MSH:D011782
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:D-8505
database_cross_reference: SNMI:DA-26008
database_cross_reference: SNOMEDCT_US:38023001

leiomyoma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that is a benign tumor of smooth muscle cells.
PMOID: PMO:00027358
Subclass_of: cell type benign neoplasm
Synonym: Fibroid
Synonym: Fibroid Neoplasm
Synonym: Fibroid Tumor
Synonym: Fibroid Tumors
Synonym: Fibroids
Synonym: Fibromyoma
Synonym: Fibromyomas
Synonym: LEIOMYOMA
Synonym: LEIOMYOMA, BENIGN
Synonym: Leiomyofibroma
Tree Number: T10.2.3.1.4
database_cross_reference: AOD:0000004542
database_cross_reference: BI:BI00407
database_cross_reference: CCPSS:0037156
database_cross_reference: CHV:0000007288
database_cross_reference: COSTAR:449
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2011-3663
database_cross_reference: DO:DOID:127
database_cross_reference: ICD10AM:M8890/0
database_cross_reference: LNC:LA26513-4
database_cross_reference: MDR:10016628
database_cross_reference: MDR:10024184
database_cross_reference: MDR:10024185
database_cross_reference: MSH:D007889
database_cross_reference: MTH:U002038
database_cross_reference: NCI:C3157
database_cross_reference: NCI_CDISC:C3157
database_cross_reference: NCI_NCI-GLOSS:CDR0000044870
database_cross_reference: NCI_NCI-GLOSS:CDR0000046402
database_cross_reference: NDFRT:N0000001802
database_cross_reference: OMIM:MTHU017017
database_cross_reference: RCD:BBK0.
database_cross_reference: RCD:BBK00
database_cross_reference: RCD:BBK0z
database_cross_reference: RCD:Xa99u
database_cross_reference: RCDSY:BBK0.
database_cross_reference: RCDSY:BBK00
database_cross_reference: RCDSY:BBK0z
database_cross_reference: SNM:M-8890/0
database_cross_reference: SNMI:M-88900
database_cross_reference: SNOMEDCT_US:189787000
database_cross_reference: SNOMEDCT_US:189788005
database_cross_reference: SNOMEDCT_US:189793008
database_cross_reference: SNOMEDCT_US:702978006

hyperprolactinemia
type: Class
subclass of: acquired metabolic disease
definition: An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.
PMOID: PMO:00028947
Subclass_of: acquired metabolic disease
Synonym: CHIARI-FROMMEL SYNDROME
Synonym: Chiari Frommel Syndrome
Synonym: Chiari-Frommel Syndrome
Synonym: Chiari-Frommel Syndrome [Disease/Finding]
Synonym: Chiari-Frommel syndrome
Synonym: Disease, Frommel
Synonym: Disease, Frommel's
Synonym: FROMMEL DIS
Synonym: FROMMELS DIS
Synonym: Frommel Disease
Tree Number: T10.6.1.7
database_cross_reference: CHV:0000002758
database_cross_reference: DO:DOID:12700
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000324
database_cross_reference: MDR:10063930
database_cross_reference: MSH:D002640
database_cross_reference: NDFRT:N0000000748
database_cross_reference: SNM:D-2539
database_cross_reference: SNMI:DB-11432
database_cross_reference: SNOMEDCT_US:85039006

capillary disease
type: Class
subclass of: vascular disease
definition: A vascular disease that is located_in the capillaries.
PMOID: PMO:00031838
Subclass_of: vascular disease
Synonym: 3-85 DISEASES OF THE CAPILLARIES
Synonym: CAPILLARIES
Synonym: CAPILLARY DISORDER
Synonym: Capillary Disorders
Synonym: Capillary disease
Synonym: Capillary disease, NOS
Synonym: Capillary disorder
Synonym: Capillary disorder NOS
Synonym: Capillary disorder, NOS
Synonym: Capillary vascular disease
Tree Number: T10.8.3.3.4
database_cross_reference: CHV:0000017519
database_cross_reference: CST:CAPILL FRAGIL INC
database_cross_reference: CST:CV/VASC/CAP
database_cross_reference: CST:CVCAP
database_cross_reference: DO:DOID:1271
database_cross_reference: ICD10:I78
database_cross_reference: ICD10:I78.9
database_cross_reference: ICD10AM:I78
database_cross_reference: ICD10AM:I78.9
database_cross_reference: ICD10CM:I78
database_cross_reference: ICD10CM:I78.9
database_cross_reference: ICD9CM:448
database_cross_reference: MDR:10007189
database_cross_reference: MDR:10007190
database_cross_reference: MDR:10013109
database_cross_reference: MDR:10050444
database_cross_reference: MDR:10062198
database_cross_reference: MEDCIN:210324
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:G77..
database_cross_reference: RCD:G77zz
database_cross_reference: SNM:D-7304
database_cross_reference: SNMI:D3-80010
database_cross_reference: SNMI:D3-85000
database_cross_reference: SNOMEDCT_US:155446001
database_cross_reference: SNOMEDCT_US:155449008
database_cross_reference: SNOMEDCT_US:195250004
database_cross_reference: SNOMEDCT_US:195380006
database_cross_reference: SNOMEDCT_US:195390003
database_cross_reference: SNOMEDCT_US:266324004
database_cross_reference: SNOMEDCT_US:57223003
database_cross_reference: SNOMEDCT_US:58729003

black piedra
type: Class
subclass of: superficial mycosis
definition: A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Trichosporon beigelii. Infected hairs develop soft greyish-white nodules along the shaft.
PMOID: PMO:00029289
Subclass_of: superficial mycosis
Synonym: Piedra
Synonym: Piedra (disorder)
Synonym: Piedra [Disease/Finding]
Synonym: Piedras
Synonym: Steroid-modified tinea infection
Synonym: Tinea blanca
Synonym: White piedra
Synonym: piedra
Synonym: piedras
Synonym: superficial mycosis
Tree Number: T10.7.1.1.4
database_cross_reference: CHV:0000009730
database_cross_reference: DO:DOID:0050133
database_cross_reference: DO:DOID:12711
database_cross_reference: DO:DOID:13902
database_cross_reference: MSH:D010854
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002400
database_cross_reference: SNM:D-0583
database_cross_reference: SNOMEDCT_US:154408001
database_cross_reference: SNOMEDCT_US:266218008
database_cross_reference: SNOMEDCT_US:402135006

respiratory syncytial virus infectious disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.
PMOID: PMO:00029362
Subclass_of: viral infectious disease
Synonym: INFECT RESPIRATORY SYNCYTIAL VIRUS
Synonym: Infections, Respiratory Syncytial Virus
Synonym: RESPIRATORY SYNCYTIAL VIRUS INFECT
Synonym: RESPIRATORY TRACT, SYNCYTIAL VIRUS INFECTION
Synonym: RSV - Resp syn vir infect
Synonym: RSV - Respiratory syncytial virus infection
Synonym: RSV Infections
Synonym: RSV infection
Synonym: Respirat syncyt virus infect
Synonym: Respiratory Syncytial Virus Infection
Tree Number: T10.7.2.15
database_cross_reference: CHV:0000050396
database_cross_reference: DO:DOID:1273
database_cross_reference: DXP:U001665
database_cross_reference: MDR:10039247
database_cross_reference: MDR:10052200
database_cross_reference: MDR:10061603
database_cross_reference: MEDCIN:31025
database_cross_reference: MEDLINEPLUS:3101
database_cross_reference: MSH:D018357
database_cross_reference: NCI:C3354
database_cross_reference: NCI_NICHD:C3354
database_cross_reference: NDFRT:N0000003803
database_cross_reference: RCD:Xa0BK
database_cross_reference: SNM:D-0461
database_cross_reference: SNMI:DE-33A10
database_cross_reference: SNOMEDCT_US:186750007
database_cross_reference: SNOMEDCT_US:55735004

hernia of ovary and fallopian tube
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is characterized by the protrusion of the ovary and fallopian tube through a defect inthe abominal wall.
PMOID: PMO:00029839
Subclass_of: female reproductive system disease
Synonym: Prolapse and hernia of ovary and fallopian tube
Synonym: Prolapse and hernia of ovary and fallopian tube, NOS
Synonym: Prolapse of ovary & tube
Synonym: Prolapse or hernia of ovary and fallopian tube
Synonym: prolapse and hernia of ovary and fallopian tube (diagnosis)
Tree Number: T10.8.1.4.16
database_cross_reference: DO:DOID:12735
database_cross_reference: ICD10:N83.4
database_cross_reference: ICD10AM:N83.4
database_cross_reference: ICD10CM:N83.4
database_cross_reference: ICD10CM:N83.40
database_cross_reference: ICD9CM:620.4
database_cross_reference: MDR:10036840
database_cross_reference: MEDCIN:338319

hallucinogen abuse
type: Class
subclass of: substance abuse
definition: A substance abuse that involves the recurring use of hallucinogenic drugs despite negative consequences.
PMOID: PMO:00027921
Subclass_of: substance abuse
Synonym: Hallucinogen abuse
Synonym: Hallucinogen abuse (disorder)
Synonym: hallucinogen abuse (diagnosis)
Tree Number: T10.3.3.2.9
database_cross_reference: DO:DOID:12797
database_cross_reference: ICD10CM:F16.1
database_cross_reference: ICD9CM:305.3
database_cross_reference: MDR:10019080
database_cross_reference: MEDCIN:32709
database_cross_reference: SNMI:D9-30500
database_cross_reference: SNOMEDCT_US:74851005

mucopolysaccharidosis
type: Class
subclass of: lysosomal storage disease
definition: A lysosomal storage disease that involves the accumulation of glycosaminoglycans in the tissues and their excretion in the urine.
PMOID: PMO:00029050
Subclass_of: lysosomal storage disease
Synonym: MPS - Mucopolysaccharidosis
Synonym: Mucopolysaccharidoses
Synonym: Mucopolysaccharidoses [Disease/Finding]
Synonym: Mucopolysaccharidosis
Synonym: Mucopolysaccharidosis (disorder)
Synonym: Mucopolysaccharidosis NOS
Synonym: Mucopolysaccharidosis NOS (disorder)
Synonym: Mucopolysaccharidosis [Ambiguous]
Synonym: Mucopolysaccharidosis, NOS
Synonym: Mucopolysaccharidosis, unspecified
Tree Number: T10.6.2.8.3
database_cross_reference: CHV:0000008308
database_cross_reference: CSP:1849-6106
database_cross_reference: DO:DOID:12798
database_cross_reference: ICD10:E76.3
database_cross_reference: ICD10AM:E76.3
database_cross_reference: ICD10CM:E76.3
database_cross_reference: ICD9CM:277.5
database_cross_reference: LCH:U003048
database_cross_reference: LCH_NW:sh85088232
database_cross_reference: MDR:10028093
database_cross_reference: MDR:10028096
database_cross_reference: MEDCIN:33578
database_cross_reference: MEDLINEPLUS:6389
database_cross_reference: MSH:D009083
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C61259
database_cross_reference: NCI_NICHD:C61259
database_cross_reference: NDFRT:N0000002044
database_cross_reference: RCD:C375z
database_cross_reference: RCD:XE11o
database_cross_reference: SNM:D-3810
database_cross_reference: SNMI:D6-70100
database_cross_reference: SNOMEDCT_US:11380006
database_cross_reference: SNOMEDCT_US:190936000
database_cross_reference: SNOMEDCT_US:190942001
database_cross_reference: SNOMEDCT_US:267452003

quadriplegia
type: Class
subclass of: central nervous system disease
PMOID: PMO:00030708
Subclass_of: central nervous system disease
Synonym: Bilateral Diplegia
Synonym: Paralysis of all four limbs
Synonym: QUADRAPLEGIA
Synonym: QUADRIPLEGIA
Synonym: QuaDriplegia
Synonym: Quadraplegia
Synonym: Quadriplegia
Synonym: Quadriplegia (disorder)
Synonym: Quadriplegia [Disease/Finding]
Synonym: Quadriplegia, unspecifd
Tree Number: T10.8.2.9.12
database_cross_reference: CCPSS:0042870
database_cross_reference: CHV:0000010479
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000518
database_cross_reference: CSP:2057-3626
database_cross_reference: CST:QUADRIPLEGIA
database_cross_reference: DO:DOID:12835
database_cross_reference: DXP:U003304
database_cross_reference: HPO:HP:0002445
database_cross_reference: ICD10:G82.5
database_cross_reference: ICD10AM:G82.5
database_cross_reference: ICD10AM:G82.50
database_cross_reference: ICD10CM:G82.5
database_cross_reference: ICD10CM:G82.50
database_cross_reference: ICD9CM:344.00
database_cross_reference: ICPC2P:N99020
database_cross_reference: LCH:U003982
database_cross_reference: LCH_NW:sh85109421
database_cross_reference: LNC:MTHU020808
database_cross_reference: MDR:10037714
database_cross_reference: MDR:10037719
database_cross_reference: MDR:10043385
database_cross_reference: MEDCIN:206420
database_cross_reference: MEDLINEPLUS:611
database_cross_reference: MSH:D011782
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C50721
database_cross_reference: NCI_FDA:2449
database_cross_reference: NCI_NICHD:C50721
database_cross_reference: NDFRT:N0000002566
database_cross_reference: OMIM:MTHU036518
database_cross_reference: OMIM:MTHU038030
database_cross_reference: PSY:42470
database_cross_reference: RCD:F240.
database_cross_reference: SNM:F-80950
database_cross_reference: SNMI:DA-26020
database_cross_reference: SNOMEDCT_US:11538006
database_cross_reference: SNOMEDCT_US:155030003

thyroid crisis
type: Class
subclass of: thyroid gland disease
PMOID: PMO:00033192
Subclass_of: thyroid gland disease
Synonym: CRISIS THYROID
Synonym: CRISIS THYROTOX
Synonym: Crisis thyroid
Synonym: Crisis, Thyroid
Synonym: Crisis, Thyrotoxic
Synonym: Hyperthyroidism with Storm
Synonym: Storm, Thyroid
Synonym: Storm, Thyrotoxic
Synonym: THYROID CRISIS
Synonym: THYROID STORM
Tree Number: T10.8.8.3.9
database_cross_reference: AOD:0000023566
database_cross_reference: CCPSS:1013285
database_cross_reference: CHV:0000012258
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:HYPERTHYR
database_cross_reference: DO:DOID:12837
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001874
database_cross_reference: DXP:U004023
database_cross_reference: HPO:HP:0011782
database_cross_reference: ICD10:E05.5
database_cross_reference: ICD10AM:E05.5
database_cross_reference: MDR:10011397
database_cross_reference: MDR:10043705
database_cross_reference: MDR:10043773
database_cross_reference: MDR:10043786
database_cross_reference: MEDCIN:30533
database_cross_reference: MSH:D013958
database_cross_reference: NCI:C112836
database_cross_reference: NCI_NICHD:C112836
database_cross_reference: NDFRT:N0000002941
database_cross_reference: RCD:X40H3
database_cross_reference: SNM:D-2192
database_cross_reference: SNMI:DB-80210
database_cross_reference: SNOMEDCT_US:190262002
database_cross_reference: SNOMEDCT_US:29028009

prolapse of female genital organ
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is characteried by the descent of one or more of the pelvic structures (bladder, uterus, vagina) from the normal anatomic location toward or through the vaginal opening.
PMOID: PMO:00029830
Subclass_of: female reproductive system disease
Synonym: Genital prolapse NEC
Synonym: Other specified genital prolapse
Tree Number: T10.8.1.4.13
database_cross_reference: DO:DOID:1284
database_cross_reference: ICD9CM:618.8
database_cross_reference: ICD9CM:618.89
database_cross_reference: MDR:10032742

ancylostomiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.
PMOID: PMO:00029664
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Uncinaria
Synonym: Infection by Uncinaria (disorder)
Synonym: Infection by Uncinaria, NOS
Synonym: Infection caused by Uncinaria
Synonym: Infection caused by Uncinaria (disorder)
Synonym: UNCINARIASIS
Synonym: Uncinariasis
Synonym: Uncinariosis
Synonym: uncinariasis
Tree Number: T10.7.4.1.32
database_cross_reference: DO:DOID:12841
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:B76
database_cross_reference: RCD:X70U6
database_cross_reference: SNM:D-0652
database_cross_reference: SNMI:DE-67030
database_cross_reference: SNOMEDCT_US:414490001
database_cross_reference: SNOMEDCT_US:85807000

rectal disease
type: Class
subclass of: intestinal disease
PMOID: PMO:00033598
Subclass_of: intestinal disease
Synonym: DISORDER RECTAL
Synonym: Disease of rectum
Synonym: Disease of rectum (disorder)
Synonym: Disease of rectum, NOS
Synonym: Disorder of rectum
Synonym: Disorder of rectum (disorder)
Synonym: Disorder rectal
Synonym: RECTAL DIS
Synonym: RECTAL DISORDER
Synonym: Rectal Disease
Tree Number: T10.8.11.8.17
database_cross_reference: CHV:0000010647
database_cross_reference: CSP:1248-3799
database_cross_reference: CST:DIG/REC
database_cross_reference: CST:RECTAL DIS
database_cross_reference: DO:DOID:1285
database_cross_reference: LCH_NW:sh85112006
database_cross_reference: MDR:10013261
database_cross_reference: MDR:10038060
database_cross_reference: MDR:10038061
database_cross_reference: MEDLINEPLUS:5870
database_cross_reference: MSH:D012002
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002578
database_cross_reference: SNM:D-6280
database_cross_reference: SNMI:D5-45000
database_cross_reference: SNOMEDCT_US:5964004

cardiovascular system disease
type: Class
subclass of: disease of anatomical entity
definition: A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
PMOID: PMO:00031598
Subclass_of: disease of anatomical entity
Synonym: 3-00 CARDIOVASCULAR DISORDERS: GENERAL TERMS
Synonym: Ascvd
Synonym: CARDIOVASC DIS
Synonym: CARDIOVASCULAR DISEASE
Synonym: CARDIOVASCULAR DISORDER
Synonym: CARDIOVASCULAR DISORDER (NOS)
Synonym: CARDIOVASCULAR DISORDERS
Synonym: CARDIOVASCULAR DISORDERS: GENERAL TERMS
Synonym: CHAPTER 3 DISEASES OF THE CARDIOVASCULAR SYSTEM
Synonym: CV disorders
Tree Number: T10.8.3
database_cross_reference: AOD:0000005252
database_cross_reference: CCPSS:1006766
database_cross_reference: CHV:0000002460
database_cross_reference: CSP:0571-0209
database_cross_reference: CST:CARDIOVASC DIS
database_cross_reference: CST:CV
database_cross_reference: DO:DOID:1287
database_cross_reference: HPO:HP:0001626
database_cross_reference: ICD10:I51.6
database_cross_reference: ICD10AM:I51.6
database_cross_reference: ICD9CM:429.2
database_cross_reference: ICPC2P:K99011
database_cross_reference: LCH_NW:sh85020229
database_cross_reference: LNC:LP193305-2
database_cross_reference: LNC:LP97118-1
database_cross_reference: MDR:10007648
database_cross_reference: MDR:10007649
database_cross_reference: MDR:10007650
database_cross_reference: MDR:10013200
database_cross_reference: MDR:10048496
database_cross_reference: MEDCIN:38666
database_cross_reference: MEDLINEPLUS:277
database_cross_reference: MEDLINEPLUS:533
database_cross_reference: MSH:D002318
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:429.2
database_cross_reference: NCI:C2931
database_cross_reference: NCI_NICHD:C2931
database_cross_reference: NDFRT:N0000000689
database_cross_reference: PSY:07640
database_cross_reference: RCD:Gyu5g
database_cross_reference: RCD:XE0UX
database_cross_reference: RCDSY:Gyu5g
database_cross_reference: SNM:D-7000
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D3-00000
database_cross_reference: SNOMEDCT_US:155263000
database_cross_reference: SNOMEDCT_US:194707003
database_cross_reference: SNOMEDCT_US:195139006
database_cross_reference: SNOMEDCT_US:195594006
database_cross_reference: SNOMEDCT_US:266275004
database_cross_reference: SNOMEDCT_US:266336005
database_cross_reference: SNOMEDCT_US:49601007

hypochondriasis
type: Class
subclass of: somatoform disorder
definition: A somatoform disorder that involves an excessive preoccupation or worry about having a serious illness.
PMOID: PMO:00028131
Subclass_of: somatoform disorder
Synonym: HYPOCHONDRIA
Synonym: HYPOCHONDRIASIS
Synonym: Hypochondria
Synonym: Hypochondriacal Neuroses
Synonym: Hypochondriacal Neurosis
Synonym: Hypochondriacal disorder
Synonym: Hypochondriacal disorder (disorder)
Synonym: Hypochondriacal disorders
Synonym: Hypochondriacal neurosis
Synonym: Hypochondriasis
Tree Number: T10.3.6.6
database_cross_reference: AOD:0000006622
database_cross_reference: CCPSS:0048714
database_cross_reference: CHV:0000006470
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2483-6952
database_cross_reference: CST:NEUROSIS
database_cross_reference: DO:DOID:12883
database_cross_reference: DXP:U002045
database_cross_reference: ICD10:F45.2
database_cross_reference: ICD10AM:F45.2
database_cross_reference: ICD10CM:F45.2
database_cross_reference: ICD10CM:F45.21
database_cross_reference: ICD9CM:300.7
database_cross_reference: ICPC2P:P75005
database_cross_reference: ICPC2P:P75010
database_cross_reference: LCH:U005673
database_cross_reference: LCH_NW:sh85063763
database_cross_reference: MDR:10020965
database_cross_reference: MEDCIN:318763
database_cross_reference: MEDCIN:32796
database_cross_reference: MSH:D006998
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C9493
database_cross_reference: NDFRT:N0000001633
database_cross_reference: PSY:23950
database_cross_reference: RCD:E207.
database_cross_reference: SNM:D-9241
database_cross_reference: SNM:F-92250
database_cross_reference: SNMI:D9-82040
database_cross_reference: SNOMEDCT_US:154891008
database_cross_reference: SNOMEDCT_US:18193002
database_cross_reference: SNOMEDCT_US:192433006

neurodegenerative disease
type: Class
subclass of: central nervous system disease
definition: A central nervous system disease that results in the progressive deterioration of function or structure of neurons.
PMOID: PMO:00030241
Subclass_of: central nervous system disease
Synonym: DEGENERATIVE DIS NERVOUS SYSTEM
Synonym: DEGENERATIVE DIS NEUROLOGIC
Synonym: DEGENERATIVE NEUROLOGIC DIS
Synonym: Degenerative Condition, Neurologic
Synonym: Degenerative Conditions, Neurologic
Synonym: Degenerative Diseases and Syndromes of Nervous System
Synonym: Degenerative Diseases, Nervous System
Synonym: Degenerative Diseases, Neurologic
Synonym: Degenerative Neurologic Disease
Synonym: Degenerative Neurologic Diseases
Tree Number: T10.8.2.9.3
database_cross_reference: CCPSS:0045760
database_cross_reference: CHV:0000038351
database_cross_reference: DO:DOID:1289
database_cross_reference: HPO:HP:0002180
database_cross_reference: ICD10:G31.9
database_cross_reference: ICD10AM:G31.9
database_cross_reference: ICD10CM:G31.9
database_cross_reference: LNC:LA12677-3
database_cross_reference: MDR:10053643
database_cross_reference: MEDCIN:335111
database_cross_reference: MEDLINEPLUS:619
database_cross_reference: MSH:D019636
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003949
database_cross_reference: PSY:33692
database_cross_reference: SNM:D-8740
database_cross_reference: SNM:NOCODE

Poland syndrome
type: Class
subclass of: physical disorder
PMOID: PMO:00028283
Subclass_of: physical disorder
Synonym: Anomaly, Poland
Synonym: POLAND ANOMALY
Synonym: POLAND SEQUENCE
Synonym: POLAND SYNDACTYLY
Synonym: POLAND SYNDROME
Synonym: POLAND'S SYNDROME
Synonym: Poland Anomaly
Synonym: Poland Sequence
Synonym: Poland Syndactyly
Synonym: Poland Syndrome
Tree Number: T10.4.20
database_cross_reference: CHV:0000009891
database_cross_reference: CST:ANOMALY CONGEN MS
database_cross_reference: DO:DOID:12961
database_cross_reference: ICD10CM:Q79.8
database_cross_reference: MDR:10036006
database_cross_reference: MDR:10036007
database_cross_reference: MDR:10042835
database_cross_reference: MEDCIN:314720
database_cross_reference: MSH:D011045
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85017
database_cross_reference: NCI_NICHD:C85017
database_cross_reference: NDFRT:N0000002448
database_cross_reference: OMIM:173800
database_cross_reference: OMIM:MTHU019848
database_cross_reference: RCD:PF594
database_cross_reference: SNM:D-5175
database_cross_reference: SNMI:D4-00915
database_cross_reference: SNOMEDCT_US:205524002
database_cross_reference: SNOMEDCT_US:38371006

leukostasis
type: Class
subclass of: leukocyte disease
PMOID: PMO:00033397
Subclass_of: leukocyte disease
Synonym: Leukostases
Synonym: Leukostasis
Synonym: Leukostasis (morphologic abnormality)
Synonym: Leukostasis Syndrome
Synonym: Leukostasis Syndromes
Synonym: Leukostasis [Disease/Finding]
Synonym: Leukostasis syndrome
Synonym: Syndrome, Leukostasis
Synonym: Syndromes, Leukostasis
Tree Number: T10.8.10.6.2
database_cross_reference: DO:DOID:12986
database_cross_reference: MDR:10024404
database_cross_reference: MDR:10074608
database_cross_reference: MSH:D018921
database_cross_reference: NCI:C4062
database_cross_reference: NDFRT:N0000003880
database_cross_reference: SNM:M-78730
database_cross_reference: SNMI:M-64230
database_cross_reference: SNOMEDCT_US:30419000

conduct disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.
PMOID: PMO:00027938
Subclass_of: specific developmental disorder
Synonym: CONDUCT DIS
Synonym: CONDUCT DISORDER
Synonym: Conduct Disorder
Synonym: Conduct Disorder [Disease/Finding]
Synonym: Conduct Disorders
Synonym: Conduct behavior disorder
Synonym: Conduct behaviour disorder
Synonym: Conduct disorder
Synonym: Conduct disorder (disorder)
Synonym: Conduct disorder NOS
Tree Number: T10.3.5.1.1
database_cross_reference: AOD:0000006695
database_cross_reference: CHV:0000016641
database_cross_reference: COSTAR:U000152
database_cross_reference: CSP:4005-0013
database_cross_reference: DO:DOID:12995
database_cross_reference: ICD10:F91
database_cross_reference: ICD10:F91.9
database_cross_reference: ICD10AM:F91
database_cross_reference: ICD10AM:F91.9
database_cross_reference: ICD10CM:F91
database_cross_reference: ICD10CM:F91.9
database_cross_reference: ICD9CM:312.9
database_cross_reference: ICPC2P:P21002
database_cross_reference: ICPC2P:P29029
database_cross_reference: MDR:10045849
database_cross_reference: MDR:10064279
database_cross_reference: MDR:10064288
database_cross_reference: MDR:10064478
database_cross_reference: MEDCIN:212798
database_cross_reference: MEDLINEPLUS:184
database_cross_reference: MSH:D019955
database_cross_reference: NCI:C89329
database_cross_reference: NCI_NICHD:C89329
database_cross_reference: NDFRT:N0000003968
database_cross_reference: PSY:11187
database_cross_reference: RCD:E2Cz.
database_cross_reference: RCD:E2Czz
database_cross_reference: RCD:Eu91.
database_cross_reference: RCDSY:Eu91.
database_cross_reference: SNOMEDCT_US:154945001
database_cross_reference: SNOMEDCT_US:192104004
database_cross_reference: SNOMEDCT_US:192106002
database_cross_reference: SNOMEDCT_US:192597006
database_cross_reference: SNOMEDCT_US:192603009
database_cross_reference: SNOMEDCT_US:268782006
database_cross_reference: SNOMEDCT_US:268785008
database_cross_reference: SNOMEDCT_US:430909002

subclavian steal syndrome
type: Class
subclass of: syndrome
PMOID: PMO:00025173
Subclass_of: syndrome
Synonym: Artery Stenoses, Subclavian
Synonym: Artery Stenosis, Subclavian
Synonym: BRACHIAL-BASILAR INSUFFICIENCY SYNDROME
Synonym: Basilar Steal Syndrome
Synonym: Basilar Steal Syndromes
Synonym: Brachial Basilar Insufficiency Syndrome
Synonym: Brachial-Basilar Insufficiency Syndrome
Synonym: Brachial-Basilar Insufficiency Syndromes
Synonym: Insufficiency Syndrome, Brachial-Basilar
Synonym: Insufficiency Syndromes, Brachial-Basilar
Tree Number: T10.1.54
database_cross_reference: CCPSS:0047326
database_cross_reference: CHV:0000011805
database_cross_reference: DO:DOID:13002
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001795
database_cross_reference: ICD9CM:435.2
database_cross_reference: ICPC2P:K89003
database_cross_reference: LCH:U004509
database_cross_reference: LCH_NW:sh85129412
database_cross_reference: MDR:10042335
database_cross_reference: MDR:10050180
database_cross_reference: MEDCIN:33347
database_cross_reference: MEDCIN:33454
database_cross_reference: MSH:D013349
database_cross_reference: NCI:C35044
database_cross_reference: NDFRT:N0000002847
database_cross_reference: RCD:G652.
database_cross_reference: RCD:Xa7lW
database_cross_reference: SNM:D-8941
database_cross_reference: SNMI:D3-89530
database_cross_reference: SNOMEDCT_US:15258001
database_cross_reference: SNOMEDCT_US:300921000

transient global amnesia
type: Class
subclass of: amnestic disorder
definition: An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.
PMOID: PMO:00028216
Subclass_of: amnestic disorder
Synonym: Amnesia, Transient Global
Synonym: Amnesia, Transient Global [Disease/Finding]
Synonym: Global Amnesia, Transient
Synonym: TGA (Transient Global Amnesia)
Synonym: TGA - Transient global amnesia
Synonym: TGAs (Transient Global Amnesia)
Synonym: Transient Global Amnesia
Synonym: Transient global amnesia
Synonym: Transient global amnesia (disorder)
Synonym: Transient global amnesia (finding)
Tree Number: T10.3.12.4.2
database_cross_reference: CHV:0000030476
database_cross_reference: DO:DOID:13027
database_cross_reference: HPO:HP:0010534
database_cross_reference: ICD10:G45.4
database_cross_reference: ICD10AM:G45.4
database_cross_reference: ICD10CM:G45.4
database_cross_reference: ICD9CM:437.7
database_cross_reference: LCH_NW:sh90002241
database_cross_reference: MDR:10044380
database_cross_reference: MEDCIN:31988
database_cross_reference: MSH:D020236
database_cross_reference: NCI:C85198
database_cross_reference: NDFRT:N0000004066
database_cross_reference: RCD:X00E2
database_cross_reference: SNOMEDCT_US:195202003
database_cross_reference: SNOMEDCT_US:230736007
database_cross_reference: SNOMEDCT_US:366963000
database_cross_reference: SNOMEDCT_US:367187006

relapsing fever
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse.
PMOID: PMO:00029497
Subclass_of: primary bacterial infectious disease
Synonym: E-137 RELAPSING FEVERS
Synonym: FEVER, FAMINE
Synonym: Fever, Relapsing
Synonym: Fever;relapsing
Synonym: Fevers, Relapsing
Synonym: RELAPSING FEVER
Synonym: RELAPSING FEVERS
Synonym: Recurrent fever
Synonym: Recurrent fever due to Borrelia
Synonym: Recurrent fever, NOS
Tree Number: T10.7.3.1.10
database_cross_reference: CHV:0000010703
database_cross_reference: CSP:0368-3338
database_cross_reference: DO:DOID:13034
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001658
database_cross_reference: ICD10:A68
database_cross_reference: ICD10:A68.9
database_cross_reference: ICD10AM:A68
database_cross_reference: ICD10AM:A68.9
database_cross_reference: ICD10CM:A68
database_cross_reference: ICD10CM:A68.9
database_cross_reference: ICD9CM:087
database_cross_reference: ICD9CM:087.9
database_cross_reference: ICPC2P:A78013
database_cross_reference: LCH:U004075
database_cross_reference: LCH_NW:sh85112485
database_cross_reference: LNC:LA10500-9
database_cross_reference: MDR:10038300
database_cross_reference: MDR:10038303
database_cross_reference: MDR:10046134
database_cross_reference: MEDCIN:31455
database_cross_reference: MSH:D012061
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002590
database_cross_reference: RCD:A87..
database_cross_reference: RCD:A87z.
database_cross_reference: RCD:Ayu54
database_cross_reference: RCDSY:Ayu54
database_cross_reference: SNM:D-0169
database_cross_reference: SNMI:DE-13700
database_cross_reference: SNOMEDCT_US:186820006
database_cross_reference: SNOMEDCT_US:186822003
database_cross_reference: SNOMEDCT_US:187374004
database_cross_reference: SNOMEDCT_US:420079008
database_cross_reference: SNOMEDCT_US:46107006

dementia
type: Class
subclass of: cognitive disorder
PMOID: PMO:00028211
Subclass_of: cognitive disorder
Synonym: DEMENTIA PRESENILE
Synonym: DEMENTIA, PRESENILE
Synonym: Dementia (Presenile)
Synonym: Dementia presenile
Synonym: Dementia, Presenile
Synonym: Pre-Senile Dementia
Synonym: Pre-senile dementia
Synonym: Presenile Dementia
Synonym: Presenile dementia
Synonym: Presenile dementia (disorder)
Tree Number: T10.3.12.3
database_cross_reference: AOD:0000006459
database_cross_reference: AOD:0000023717
database_cross_reference: CCPSS:1010809
database_cross_reference: CHV:0000003683
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0485-6612
database_cross_reference: CSP:0485-6737
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:F03
database_cross_reference: ICD9CM:290.1
database_cross_reference: ICPC2P:P70006
database_cross_reference: LCH_NW:sh85106442
database_cross_reference: MDR:10012298
database_cross_reference: MDR:10036506
database_cross_reference: MDR:10036631
database_cross_reference: MEDCIN:312345
database_cross_reference: MSH:D000544
database_cross_reference: MTH:611
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:290.10
database_cross_reference: NCI:C34523
database_cross_reference: OMIM:MTHU006344
database_cross_reference: PSY:13400
database_cross_reference: PSY:40180
database_cross_reference: RCD:E001.
database_cross_reference: RCD:E001z
database_cross_reference: RCD:E00z.
database_cross_reference: RCDSY:E00z.
database_cross_reference: SNM:D-8543
database_cross_reference: SNMI:D9-22020
database_cross_reference: SNOMEDCT_US:12348006
database_cross_reference: SNOMEDCT_US:154847008
database_cross_reference: SNOMEDCT_US:191450005
database_cross_reference: SNOMEDCT_US:191456004
database_cross_reference: SNOMEDCT_US:192180006

hemangioma of subcutaneous tissue
type: Class
subclass of: skin disease
PMOID: PMO:00027326
Subclass_of: skin disease
Synonym: Angioma of Subcutaneous Tissue
Synonym: Angioma of the Subcutaneous Tissue
Synonym: Angioma of the Subcutaneous tissue
Synonym: Haemangioma of subcutaneous tissue
Synonym: Hemangioma of Subcutaneous Tissue
Synonym: Hemangioma of subcutaneous tissue
Synonym: Hemangioma of subcutaneous tissue (disorder)
Synonym: Hemangioma of the Subcutaneous Tissue
Synonym: Subcutaneous Angioma
Synonym: Subcutaneous Hemangioma
Tree Number: T10.8.12.2.10
database_cross_reference: DO:DOID:13081
database_cross_reference: MEDCIN:336085
database_cross_reference: NCI:C8540
database_cross_reference: RCD:X78VP
database_cross_reference: RCDAE:X78VP
database_cross_reference: SNMI:D3-F0620
database_cross_reference: SNOMEDCT_US:189195009
database_cross_reference: SNOMEDCT_US:254823000
database_cross_reference: SNOMEDCT_US:93473009

Lown-Ganong-Levine syndrome
type: Class
subclass of: syndrome
definition: A syndrome that involves pre-excitation of the ventricles due to an accessory pathway providing an abnormal electrical communication from the atria to the ventricles.
PMOID: PMO:00025190
Subclass_of: syndrome
Synonym: Lown Ganong Levine Syndrome
Synonym: Lown Ganong Levine syndrome
Synonym: Lown-Ganong-Levine Syndrome
Synonym: Lown-Ganong-Levine Syndrome [Disease/Finding]
Synonym: Lown-Ganong-Levine syndrome (diagnosis)
Synonym: Lown-Ganong-Levine syndrome (disorder)
Synonym: Lown-ganong-levine synd
Synonym: Short PR Normal QRS Complex Syndrome
Synonym: Short PR-Normal QRS Complex Syndrome
Synonym: Syndrome of short P-R interval, normal QRS complexes AND supraventricular tachycardias
Tree Number: T10.1.71
database_cross_reference: BI:BI00158
database_cross_reference: CHV:0000007553
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:13087
database_cross_reference: ICD10CM:I45.6
database_cross_reference: ICD9CM:426.81
database_cross_reference: MDR:10024984
database_cross_reference: MEDCIN:33310
database_cross_reference: MSH:D008151
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:426.81
database_cross_reference: NDFRT:N0000001875
database_cross_reference: RCD:G56y0
database_cross_reference: SNMI:D3-31820
database_cross_reference: SNOMEDCT_US:55475008

paronychia
type: Class
subclass of: nail disease
definition: A nail disease characterized by often-tender bacterial or fungal hand infection or foot infection due to either bacteria or fungus (Candida albicans) where the nail and skin meet at the side or the base of a finger or toe nail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia). Puss is usually present, along with gradual thickening and browning discoloration of the nail plate.
PMOID: PMO:00033770
Subclass_of: nail disease
Synonym: Infected nailfold
Synonym: Nail bed inflammation
Synonym: Nailfold infected
Synonym: Onychia and paronychia of finger
Synonym: Onychia and paronychia of toe
Synonym: PARONYCHIA
Synonym: Paronychia
Synonym: Paronychia (disorder)
Synonym: Paronychia Inflammation
Synonym: Paronychia [Disease/Finding]
Tree Number: T10.8.12.1.12
database_cross_reference: CCPSS:0024127
database_cross_reference: CHV:0000009322
database_cross_reference: COSTAR:560
database_cross_reference: CST:NAIL DIS
database_cross_reference: DO:DOID:13117
database_cross_reference: HPO:HP:0001818
database_cross_reference: ICD10CM:L03.0
database_cross_reference: ICPC2P:S09007
database_cross_reference: LCH:U003488
database_cross_reference: LCH_NW:sh85098260
database_cross_reference: MDR:10034016
database_cross_reference: MDR:10064088
database_cross_reference: MEDCIN:31291
database_cross_reference: MEDLINEPLUS:532
database_cross_reference: MSH:D010304
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C79702
database_cross_reference: NCI_CTCAE:E11497
database_cross_reference: NCI_NICHD:C79702
database_cross_reference: NDFRT:N0000002330
database_cross_reference: OMIM:MTHU014750
database_cross_reference: RCD:X75vf
database_cross_reference: SNM:M-40400
database_cross_reference: SNMI:D0-54400
database_cross_reference: SNOMEDCT_US:156305000
database_cross_reference: SNOMEDCT_US:200643006
database_cross_reference: SNOMEDCT_US:267830000
database_cross_reference: SNOMEDCT_US:71906005
database_cross_reference: SNOMEDCT_VET:71906005

deficiency anemia
type: Class
subclass of: anemia
PMOID: PMO:00033360
Subclass_of: anemia
Synonym: ANEMIA DEFICIENCY NOS
Synonym: Anaemia deficiencies
Synonym: Anemia deficiencies
Synonym: Deficiency Anemia
Synonym: Deficiency anaemia
Synonym: Deficiency anaemia NOS
Synonym: Deficiency anaemias
Synonym: Deficiency anaemias NOS
Synonym: Deficiency anemia
Synonym: Deficiency anemia NOS
Tree Number: T10.8.10.4.3
database_cross_reference: CCPSS:0045105
database_cross_reference: CHV:0000012740
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:13121
database_cross_reference: ICD9CM:281.9
database_cross_reference: MDR:10002042
database_cross_reference: MDR:10012129
database_cross_reference: MDR:10045728
database_cross_reference: MDR:10045729
database_cross_reference: MDR:10054368
database_cross_reference: MDR:10061101
database_cross_reference: RCD:D0z..
database_cross_reference: RCD:XE13b
database_cross_reference: RCDAE:D0z..
database_cross_reference: RCDAE:XE13b
database_cross_reference: SNOMEDCT_US:191125001
database_cross_reference: SNOMEDCT_US:191168000
database_cross_reference: SNOMEDCT_US:267513007

esophageal diverticulosis
type: Class
subclass of: esophageal disease
PMOID: PMO:00033440
Subclass_of: esophageal disease
Synonym: Diverticulosis, Esophageal
Synonym: Diverticulosis, Esophageal [Disease/Finding]
Synonym: Diverticulosis;esophagus
Synonym: Diverticulosis;oesophagus
Synonym: Esophageal Diverticulosis
Synonym: Esophageal diverticulosis
Synonym: oesophageal diverticulosis
Tree Number: T10.8.11.2.2
database_cross_reference: DO:DOID:13185
database_cross_reference: ICPC2P:D84010
database_cross_reference: MSH:D045723
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000010976

megaesophagus
type: Class
subclass of: esophageal disease
PMOID: PMO:00033441
Subclass_of: esophageal disease
Synonym: Esophagus dilated
Synonym: Megaesophagus
Synonym: Megaesophagus (disorder)
Synonym: Megaoesophagus
Synonym: megaesophagus (diagnosis)
Tree Number: T10.8.11.2.3
database_cross_reference: CHV:0000007882
database_cross_reference: DO:DOID:13186
database_cross_reference: MDR:10052061
database_cross_reference: MDR:10056100
database_cross_reference: MEDCIN:276033
database_cross_reference: MSH:D004931
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:530.0
database_cross_reference: NCI:C34811
database_cross_reference: RCD:J100.
database_cross_reference: RCDAE:J100.
database_cross_reference: SNM:M-32220
database_cross_reference: SNMI:D5-30234
database_cross_reference: SNOMEDCT_US:70667005
database_cross_reference: SNOMEDCT_VET:70667005

Haverhill fever
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.
PMOID: PMO:00029589
Subclass_of: primary bacterial infectious disease
Synonym: Streptobacillary fever
Tree Number: T10.7.3.1.41
database_cross_reference: DO:DOID:13238

mucocele of appendix
type: Class
subclass of: intestinal disease
PMOID: PMO:00033543
Subclass_of: intestinal disease
Synonym: Appendiceal Mucocele
Synonym: Appendiceal mucocele
Synonym: Appendiceal mucocoele
Synonym: Appendicele Mucocele
Synonym: Appendicular mucocele
Synonym: Mucocele of Appendix
Synonym: Mucocele of appendix
Synonym: Mucocele of appendix (disorder)
Synonym: Mucocele of the Appendix
Synonym: appendiceal mucocele
Tree Number: T10.8.11.8.8
database_cross_reference: CHV:0000008302
database_cross_reference: DO:DOID:13248
database_cross_reference: MDR:10057986
database_cross_reference: MDR:10057996
database_cross_reference: MEDCIN:96114
database_cross_reference: MTHICD9:543.9
database_cross_reference: NCI:C3241
database_cross_reference: RCD:J23z5
database_cross_reference: SNM:M-33200
database_cross_reference: SNMI:D5-46460
database_cross_reference: SNOMEDCT_US:53773002

pneumatosis cystoides intestinalis
type: Class
subclass of: intestinal disease
PMOID: PMO:00033546
Subclass_of: intestinal disease
Synonym: Cystoides Intestinalis, Pneumatosis
Synonym: EMPHYSEMA, INTESTINAL
Synonym: INTESTINE, GAS CYSTS
Synonym: Intestinalis, Pneumatosis Cystoides
Synonym: PCI - Pneum cystoides intestin
Synonym: PCI - Pneumatosis cystoides intestinalis
Synonym: PNEUMATOSIS CYSTOIDES INTESTINALIS
Synonym: Pneumatosis Cystoides Intestinalis
Synonym: Pneumatosis Cystoides Intestinalis [Disease/Finding]
Synonym: Pneumatosis coli
Tree Number: T10.8.11.8.10
database_cross_reference: CHV:0000009860
database_cross_reference: DO:DOID:13249
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001519
database_cross_reference: MDR:10049732
database_cross_reference: MDR:10070461
database_cross_reference: MEDCIN:30195
database_cross_reference: MEDCIN:30196
database_cross_reference: MSH:D011006
database_cross_reference: NDFRT:N0000002428
database_cross_reference: RCD:X3052
database_cross_reference: SNM:M-33910
database_cross_reference: SNMI:D5-43320
database_cross_reference: SNOMEDCT_US:117631000119103
database_cross_reference: SNOMEDCT_US:17465007

diarrhea
type: Class
subclass of: gastrointestinal system disease
PMOID: PMO:00033742
Subclass_of: gastrointestinal system disease
Synonym: D - Diarrhea
Synonym: D - Diarrhoea
Synonym: DIARRHEA
Synonym: DIARRHOEA
Synonym: Diarrhea
Synonym: Diarrhea (finding)
Synonym: Diarrhea NOS
Synonym: Diarrhea [Disease/Finding]
Synonym: Diarrhea symptom
Synonym: Diarrhea symptom (finding)
Tree Number: T10.8.11.14
database_cross_reference: AOD:0000005512
database_cross_reference: BI:BI00232
database_cross_reference: CCPSS:1017488
database_cross_reference: CHV:0000003866
database_cross_reference: CHV:0000037039
database_cross_reference: COSTAR:237
database_cross_reference: CSP:1248-4166
database_cross_reference: CST:DIARRHEA
database_cross_reference: DXP:U000964
database_cross_reference: HPO:HP:0002014
database_cross_reference: ICD10CM:R19.7
database_cross_reference: ICD9CM:787.91
database_cross_reference: ICPC2EENG:D11
database_cross_reference: ICPC2P:D11001
database_cross_reference: ICPC2P:D11002
database_cross_reference: LCH:U001379
database_cross_reference: LCH_NW:sh85037604
database_cross_reference: LNC:LA15424-7
database_cross_reference: LNC:MTHU013347
database_cross_reference: MDR:10012727
database_cross_reference: MDR:10012732
database_cross_reference: MDR:10012735
database_cross_reference: MDR:10012745
database_cross_reference: MEDCIN:314464
database_cross_reference: MEDCIN:435
database_cross_reference: MEDLINEPLUS:211
database_cross_reference: MSH:D003967
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:787.91
database_cross_reference: NCI:C2987
database_cross_reference: NCI_CTCAE:E10572
database_cross_reference: NCI_FDA:1811
database_cross_reference: NCI_NCI-GLOSS:CDR0000306496
database_cross_reference: NCI_NICHD:C2987
database_cross_reference: NDFRT:N0000000963
database_cross_reference: OMIM:MTHU000226
database_cross_reference: OMIM:MTHU050187
database_cross_reference: PDQ:CDR0000041619
database_cross_reference: PSY:14050
database_cross_reference: RCD:19F2.
database_cross_reference: RCD:XE0rN
database_cross_reference: RCD:XE0rO
database_cross_reference: RCD:Xa7VN
database_cross_reference: RCDAE:19F2.
database_cross_reference: RCDAE:XE0rN
database_cross_reference: RCDAE:XE0rO
database_cross_reference: RCDAE:Xa7VN
database_cross_reference: SNM:F-62400
database_cross_reference: SNMI:F-54400
database_cross_reference: SNOMEDCT_US:139381002
database_cross_reference: SNOMEDCT_US:139383004
database_cross_reference: SNOMEDCT_US:162103003
database_cross_reference: SNOMEDCT_US:162105005
database_cross_reference: SNOMEDCT_US:162108007
database_cross_reference: SNOMEDCT_US:267060006
database_cross_reference: SNOMEDCT_US:267061005
database_cross_reference: SNOMEDCT_US:300388003
database_cross_reference: SNOMEDCT_US:62315008

typhoid fever
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.
PMOID: PMO:00029580
Subclass_of: primary bacterial infectious disease
Synonym: Abdominal Typhus
Synonym: Enteric Fever
Synonym: Enteric Fevers
Synonym: Enteric fever
Synonym: FEVER, ENTERIC
Synonym: Fever, Enteric
Synonym: Fever, Typhoid
Synonym: Fever: [typhoid] or [enteric]
Synonym: Fever: [typhoid] or [enteric] (disorder)
Synonym: Fevers, Enteric
Tree Number: T10.7.3.1.36
database_cross_reference: AOD:0000004852
database_cross_reference: CCPSS:0053854
database_cross_reference: CHV:0000012684
database_cross_reference: COSTAR:U000692
database_cross_reference: CSP:0368-2741
database_cross_reference: DO:DOID:13258
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001941
database_cross_reference: DXP:U004176
database_cross_reference: ICD10:A01.0
database_cross_reference: ICD10AM:A01.0
database_cross_reference: ICD10CM:A01.0
database_cross_reference: ICD10CM:A01.00
database_cross_reference: ICD9CM:002.0
database_cross_reference: ICPC2P:D70030
database_cross_reference: LCH_NW:sh85139156
database_cross_reference: LNC:LA16615-9
database_cross_reference: MDR:10014862
database_cross_reference: MDR:10039446
database_cross_reference: MDR:10045272
database_cross_reference: MDR:10045275
database_cross_reference: MEDCIN:31381
database_cross_reference: MEDLINEPLUS:1213
database_cross_reference: MSH:D014435
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:002.0
database_cross_reference: NCI:C35089
database_cross_reference: NCI_NICHD:C35089
database_cross_reference: NDFRT:N0000003059
database_cross_reference: RCD:XE0Qd
database_cross_reference: SNM:D-0190
database_cross_reference: SNMI:DE-15100
database_cross_reference: SNOMEDCT_US:154270009
database_cross_reference: SNOMEDCT_US:186091002
database_cross_reference: SNOMEDCT_US:266174006
database_cross_reference: SNOMEDCT_US:4834000

porphyria
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins.
PMOID: PMO:00029033
Subclass_of: inherited metabolic disorder
Synonym: 6-88 DISORDERS OF PORPHYRIN METABOLISM
Synonym: DISORDERS OF PORPHYRIN METABOLISM
Synonym: Dis porphyrin metabolism
Synonym: Disord of porphyrin & haem met
Synonym: Disorder of porphyrin and haem metabolism
Synonym: Disorder of porphyrin and hem metabolism
Synonym: Disorder of porphyrin and heme metabolism
Synonym: Disorder of porphyrin and heme metabolism (disorder)
Synonym: Disorder of porphyrin metabolism
Synonym: Disorder of porphyrin metabolism (disorder)
Tree Number: T10.6.2.6
database_cross_reference: AOD:0000005783
database_cross_reference: AOD:0000005784
database_cross_reference: AOD:0000023469
database_cross_reference: CCPSS:0009853
database_cross_reference: CCPSS:0031656
database_cross_reference: CHV:0000009972
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-7403
database_cross_reference: CST:METPORPHYRIA
database_cross_reference: CST:PORPHYRIA
database_cross_reference: DO:DOID:13268
database_cross_reference: ICD10CM:E80.20
database_cross_reference: ICD9CM:277.1
database_cross_reference: ICPC2P:T99026
database_cross_reference: LCH:U003771
database_cross_reference: LCH_NW:sh85105021
database_cross_reference: MDR:10013349
database_cross_reference: MDR:10036181
database_cross_reference: MDR:10036188
database_cross_reference: MDR:10036190
database_cross_reference: MDR:10061356
database_cross_reference: MEDCIN:33596
database_cross_reference: MEDCIN:337572
database_cross_reference: MEDLINEPLUS:1249
database_cross_reference: MSH:D011164
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.1
database_cross_reference: NCI:C97096
database_cross_reference: NDFRT:N0000002464
database_cross_reference: OMIM:MTHU018705
database_cross_reference: PSY:39590
database_cross_reference: RCD:C371.
database_cross_reference: RCD:C371z
database_cross_reference: RCD:X40WP
database_cross_reference: RCD:XM0qH
database_cross_reference: SNM:D-4200
database_cross_reference: SNM:U000011
database_cross_reference: SNMI:D6-88000
database_cross_reference: SNMI:D6-88100
database_cross_reference: SNOMEDCT_US:154768004
database_cross_reference: SNOMEDCT_US:190912004
database_cross_reference: SNOMEDCT_US:190916001
database_cross_reference: SNOMEDCT_US:238052001
database_cross_reference: SNOMEDCT_US:274090006
database_cross_reference: SNOMEDCT_US:29094004
database_cross_reference: SNOMEDCT_US:371628009
database_cross_reference: SNOMEDCT_US:418470004
database_cross_reference: SNOMEDCT_US:86292002

cutaneous porphyria
type: Class
subclass of: porphyria
PMOID: PMO:00029041
Subclass_of: porphyria
Synonym: CEP
Synonym: CEP - Congenital erythropoietic porphyria
Synonym: CEP-Cong erythropoietic porphy
Synonym: CONGEN ERYTHROPOIETIC PORPHYRIA
Synonym: Congen erythropoietic porphyr
Synonym: Congen photosensitive porphyr
Synonym: Congenital Erythropoietic Porphyria
Synonym: Congenital Erythropoietic Porphyrias
Synonym: Congenital erythropoietic porphyria
Synonym: Congenital erythropoietic porphyria (disorder)
Tree Number: T10.6.2.6.2
database_cross_reference: CHV:0000017876
database_cross_reference: CSP:1849-7617
database_cross_reference: DO:DOID:13271
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001561
database_cross_reference: ICD10:E80.0
database_cross_reference: ICD10AM:E80.0
database_cross_reference: ICD10CM:E80.0
database_cross_reference: MDR:10015288
database_cross_reference: MEDCIN:33598
database_cross_reference: MSH:D017092
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84697
database_cross_reference: NDFRT:N0000003526
database_cross_reference: OMIM:263700
database_cross_reference: OMIM:606938
database_cross_reference: RCD:C3710
database_cross_reference: RCD:X40WR
database_cross_reference: SNM:D-4210
database_cross_reference: SNM:D-4211
database_cross_reference: SNMI:D6-88200
database_cross_reference: SNMI:D6-88210
database_cross_reference: SNOMEDCT_US:190913009
database_cross_reference: SNOMEDCT_US:22935002
database_cross_reference: SNOMEDCT_US:67312003

Rift Valley fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.
PMOID: PMO:00029425
Subclass_of: viral infectious disease
Tree Number: T10.7.2.59
database_cross_reference: DO:DOID:1328

diphtheritic peritonitis
type: Class
subclass of: peritonitis
definition: A peritonitis which involves inflammation of peritoneal cavity by Corynebacterium diphtheriae.
PMOID: PMO:00033525
Subclass_of: peritonitis
Synonym: Diphtheritic peritonitis
Synonym: Diphtheritic peritonitis (disorder)
Synonym: diphtheritic peritonitis (diagnosis)
Tree Number: T10.8.11.7.1
database_cross_reference: DO:DOID:13310
database_cross_reference: ICD10CM:A36.89
database_cross_reference: ICD9CM:032.83
database_cross_reference: MDR:10013028
database_cross_reference: MEDCIN:97389
database_cross_reference: RCD:A32y2
database_cross_reference: SNMI:DE-11780
database_cross_reference: SNOMEDCT_US:13596001

pancreatic mucinous ductal ectasia
type: Class
subclass of: pancreas disease
PMOID: PMO:00033199
Subclass_of: pancreas disease
Synonym: Pancreatic Mucinous Ductal Ectasia
Tree Number: T10.8.8.4.3
database_cross_reference: DO:DOID:13313
database_cross_reference: NCI:C5717

exocrine pancreatic insufficiency
type: Class
subclass of: pancreas disease
PMOID: PMO:00033200
Subclass_of: pancreas disease
Synonym: EPI
Synonym: Exocrine Pancreas Insufficiency
Synonym: Exocrine Pancreatic Insufficiencies
Synonym: Exocrine Pancreatic Insufficiency
Synonym: Exocrine Pancreatic Insufficiency [Disease/Finding]
Synonym: Exocrine pancreatic insufficiency
Synonym: Exocrine pancreatic insufficiency (EPI)
Synonym: Exocrine pancreatic insufficiency (diagnosis)
Synonym: Exocrine pancreatic insufficiency (disorder)
Synonym: Insufficiencies, Exocrine Pancreatic
Tree Number: T10.8.8.4.4
database_cross_reference: CCPSS:0014149
database_cross_reference: CHV:0000026237
database_cross_reference: DO:DOID:13316
database_cross_reference: HPO:HP:0001738
database_cross_reference: ICD10CM:K86.81
database_cross_reference: MDR:10073392
database_cross_reference: MEDCIN:363695
database_cross_reference: MSH:D010188
database_cross_reference: MTH:U000150
database_cross_reference: NCI:C84316
database_cross_reference: NDFRT:N0000011093
database_cross_reference: OMIM:MTHU010290
database_cross_reference: OMIM:MTHU051129
database_cross_reference: SNMI:D5-90550
database_cross_reference: SNOMEDCT_US:47367009

hyperinsulinemic hypoglycemia
type: Class
subclass of: carbohydrate metabolic disorder
definition: A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin.
PMOID: PMO:00029127
Subclass_of: carbohydrate metabolic disorder
Synonym: Fam hyperinsulin panc nesidiob
Synonym: Familial hyperinsulinaemia with pancreatic nesidioblastosis
Synonym: Familial hyperinsulinemia with pancreatic nesidioblastosis
Synonym: HYPERINSULINISM, FAMILIAL, WITH PANCREATIC NESIDIOBLASTOSIS
Synonym: Hyperinsulin-panc islet B cell
Synonym: Hyperinsulinaemia due to nesidioblastosis
Synonym: Hyperinsulinaemia due to nesidioblastosis [Ambiguous]
Synonym: Hyperinsulinaemia due to pancreatic islet beta cell hyperplasia
Synonym: Hyperinsulinaemia-nesidioblast
Synonym: Hyperinsulinaemia-pancreatic islet beta cell hyperplasia
Tree Number: T10.6.2.11.6
database_cross_reference: CHV:0000008610
database_cross_reference: DO:DOID:13317
database_cross_reference: ICD10CM:E16.9
database_cross_reference: MEDCIN:30268
database_cross_reference: MSH:D046768
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:251.9
database_cross_reference: NCI:C4375
database_cross_reference: NCI_NICHD:C4375
database_cross_reference: NDFRT:N0000011080
database_cross_reference: OMIM:256450
database_cross_reference: OMIM:601820
database_cross_reference: OMIM:MTHU023473
database_cross_reference: RCD:X309S
database_cross_reference: RCD:X40Ic
database_cross_reference: RCD:X40KE
database_cross_reference: RCDAE:X40KE
database_cross_reference: SNM:M-72000
database_cross_reference: SNMI:DB-60020
database_cross_reference: SNOMEDCT_US:190450004
database_cross_reference: SNOMEDCT_US:237649006
database_cross_reference: SNOMEDCT_US:360337007
database_cross_reference: SNOMEDCT_US:42681006
database_cross_reference: SNOMEDCT_US:66149005

pedophilia
type: Class
subclass of: paraphilia disorder
PMOID: PMO:00028156
Subclass_of: paraphilia disorder
Synonym: Paedophilia
Synonym: Paedophilia (disorder)
Synonym: Paedophilia, NOS
Synonym: Pedophilia
Synonym: Pedophilia (disorder)
Synonym: Pedophilia [Disease/Finding]
Synonym: Pedophilia, NOS
Synonym: Pedophilias
Synonym: paedophilia
Synonym: paedophilias
Tree Number: T10.3.11.2.5
database_cross_reference: AOD:0000006801
database_cross_reference: CHV:0000009391
database_cross_reference: DO:DOID:13351
database_cross_reference: ICD10:F65.4
database_cross_reference: ICD10AM:F65.4
database_cross_reference: ICD10AMAE:F65.4
database_cross_reference: ICD10CM:F65.4
database_cross_reference: ICD9CM:302.2
database_cross_reference: ICPC2P:P09005
database_cross_reference: LCH:U003513
database_cross_reference: LCH_NW:sh85099210
database_cross_reference: MDR:10033361
database_cross_reference: MDR:10034217
database_cross_reference: MEDCIN:32815
database_cross_reference: MSH:D010378
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94355
database_cross_reference: NDFRT:N0000002340
database_cross_reference: PSY:37130
database_cross_reference: RCD:E222.
database_cross_reference: RCDAE:E222.
database_cross_reference: SNM:F-99300
database_cross_reference: SNMI:D9-73200
database_cross_reference: SNOMEDCT_US:154907002
database_cross_reference: SNOMEDCT_US:192516001
database_cross_reference: SNOMEDCT_US:268763002
database_cross_reference: SNOMEDCT_US:84002002

ego-dystonic sexual orientation
type: Class
subclass of: gender identity disorder
definition: A gender identity disorder that is characterized by having a sexual orientation or an attraction that is at odds with one's idealized self-image, causing anxiety and a desire to change one's orientation or become more comfortable with one's sexual orientation.
PMOID: PMO:00027934
Subclass_of: gender identity disorder
Synonym: Ego dystonic sexual orientation
Synonym: Ego-alien sexual orientation
Synonym: Ego-dystonic sex orient
Synonym: Ego-dystonic sexual orientation
Synonym: Ego-dystonic sexual orientation (finding)
Synonym: Egodystonic sexual orientation
Synonym: Egodystonic sexual orientation disorder
Synonym: Egodystonic sexual orientation disorder (diagnosis)
Synonym: sexual disorder egodystonic sexual orientation
Tree Number: T10.3.4.1
database_cross_reference: DO:DOID:13352
database_cross_reference: ICD10:F66.1
database_cross_reference: ICD10AM:F66.1
database_cross_reference: ICD9CM:302.0
database_cross_reference: MEDCIN:364065
database_cross_reference: RCD:Eu661
database_cross_reference: SNMI:F-9B134
database_cross_reference: SNOMEDCT_US:52813007

alpha 1-antitrypsin deficiency
type: Class
subclass of: plasma protein metabolism disease
definition: A plasma protein metabolism disease that has_material_basis_in defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.
PMOID: PMO:00029044
Subclass_of: plasma protein metabolism disease
Synonym: 1 alpha antitrypsin deficiency
Synonym: A-1ATD
Synonym: A1AD
Synonym: A1ATD
Synonym: AAT deficiency
Synonym: AATD
Synonym: ALPHA 1 ANTITRYPSIN DEFIC
Synonym: ALPHA 1 ANTITRYPSIN DEFICIENCY
Synonym: ALPHA ANTITRYPSIN DEFICIENCY 01
Synonym: ALPHA-1 ANTITRYPSIN DEFICIENCY
Tree Number: T10.6.2.7.2
database_cross_reference: CHV:0000021473
database_cross_reference: COSTAR:U000093
database_cross_reference: CSP:1849-1633
database_cross_reference: DO:DOID:13372
database_cross_reference: DXP:U000070
database_cross_reference: ICD10CM:E88.01
database_cross_reference: ICD9CM:273.4
database_cross_reference: ICPC2P:T99083
database_cross_reference: LCH_NW:sh95007971
database_cross_reference: MDR:10001806
database_cross_reference: MDR:10001811
database_cross_reference: MEDCIN:33003
database_cross_reference: MEDLINEPLUS:1692
database_cross_reference: MSH:D019896
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:273.4
database_cross_reference: NCI:C84397
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NICHD:C84397
database_cross_reference: NDFRT:N0000003965
database_cross_reference: OMIM:613490
database_cross_reference: RCD:C3762
database_cross_reference: SNMI:D6-72550
database_cross_reference: SNOMEDCT_US:154771007
database_cross_reference: SNOMEDCT_US:30188007

fibrodysplasia ossificans progressiva
type: Class
subclass of: connective tissue disease
definition: .A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.
PMOID: PMO:00032300
Subclass_of: connective tissue disease
Synonym: Diffuse progressive ossifying polymyositis
Synonym: FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
Synonym: FOP
Synonym: FOP - Fibrodys oss progressiva
Synonym: FOP - Fibrodysplasia ossificans progressiva
Synonym: Fibrodysp ossificans congenita
Synonym: Fibrodyspl ossific progressiva
Synonym: Fibrodysplasia Ossificans Progressiva
Synonym: Fibrodysplasia ossificans congenita
Synonym: Fibrodysplasia ossificans progressiva
Tree Number: T10.8.4.1.16
database_cross_reference: CHV:0000005027
database_cross_reference: CSP:1982-9828
database_cross_reference: DO:DOID:13374
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001243
database_cross_reference: ICD10:M61.1
database_cross_reference: ICD10AM:M61.1
database_cross_reference: ICD10AM:M61.19
database_cross_reference: ICD10CM:M61.1
database_cross_reference: ICD10CM:M61.10
database_cross_reference: ICD9CM:728.11
database_cross_reference: MDR:10036809
database_cross_reference: MDR:10068715
database_cross_reference: MSH:D009221
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3040
database_cross_reference: OMIM:102576
database_cross_reference: OMIM:135100
database_cross_reference: RCD:N2311
database_cross_reference: SNM:M-73420
database_cross_reference: SNMI:D1-50220
database_cross_reference: SNOMEDCT_US:205527009
database_cross_reference: SNOMEDCT_US:240121004
database_cross_reference: SNOMEDCT_US:82725007

skin sarcoidosis
type: Class
subclass of: skin disease
PMOID: PMO:00032714
Subclass_of: skin disease
Synonym: Cutaneous Sarcoidosis
Synonym: Cutaneous sarcoid
Synonym: Cutaneous sarcoid (disorder)
Synonym: Cutaneous sarcoidosis
Synonym: Cutaneous sarcoidosis (disorder)
Synonym: SARCOIDOSIS SKIN
Synonym: Sarcoidosis cutaneous
Synonym: Sarcoidosis of skin
Synonym: Sarcoidosis, cutaneous
Synonym: Skin sarcoidosis
Tree Number: T10.8.12.2.23
database_cross_reference: CCPSS:0012642
database_cross_reference: CHV:0000011045
database_cross_reference: DO:DOID:13402
database_cross_reference: ICD10:D86.3
database_cross_reference: ICD10AM:D86.3
database_cross_reference: ICD10CM:D86.3
database_cross_reference: MDR:10011674
database_cross_reference: MDR:10039489
database_cross_reference: MDR:10040919
database_cross_reference: MEDCIN:270257
database_cross_reference: NCI:C34996
database_cross_reference: RCD:X20GW
database_cross_reference: SNM:D-0828
database_cross_reference: SNMI:DE-A1424
database_cross_reference: SNOMEDCT_US:187234008
database_cross_reference: SNOMEDCT_US:55941000

neurogenic bowel
type: Class
subclass of: intestinal disease
PMOID: PMO:00033592
Subclass_of: intestinal disease
Synonym: BOWEL NEUROGENIC
Synonym: Bowel, Neurogenic
Synonym: Bowels, Neurogenic
Synonym: Neurogenic Bowel
Synonym: Neurogenic Bowel [Disease/Finding]
Synonym: Neurogenic Bowels
Synonym: Neurogenic bowel
Synonym: Neurogenic bowel (disorder)
Synonym: neurogenic bowel (diagnosis)
Tree Number: T10.8.11.8.13
database_cross_reference: CCPSS:1009027
database_cross_reference: CHV:0000044212
database_cross_reference: DO:DOID:13419
database_cross_reference: ICD9CM:564.81
database_cross_reference: MDR:10048657
database_cross_reference: MEDCIN:96831
database_cross_reference: MSH:D055496
database_cross_reference: NDFRT:N0000181168
database_cross_reference: SNOMEDCT_US:425671009

urethritis
type: Class
subclass of: urethral disease
PMOID: PMO:00032968
Subclass_of: urethral disease
Synonym: Inflammation of urethra
Synonym: Non-Gonococcal Urethritis
Synonym: Nongonococcal urethritis
Synonym: URETHRITIS
Synonym: Urethral inflammation
Synonym: Urethritides
Synonym: Urethritis
Synonym: Urethritis (disorder)
Synonym: Urethritis NOS
Synonym: Urethritis [Disease/Finding]
Tree Number: T10.8.7.3.8
database_cross_reference: BI:BI00426
database_cross_reference: CCPSS:1016729
database_cross_reference: CHV:0000012771
database_cross_reference: COSTAR:763
database_cross_reference: CSP:3045-8935
database_cross_reference: CST:URETHRITIS
database_cross_reference: DO:DOID:1343
database_cross_reference: DXP:U004235
database_cross_reference: HPO:HP:0500006
database_cross_reference: ICD10CM:N34.2
database_cross_reference: ICD9CM:597.80
database_cross_reference: ICPC2P:U72005
database_cross_reference: LCH:U004859
database_cross_reference: LCH_NW:sh85141392
database_cross_reference: MDR:10046480
database_cross_reference: MDR:10046492
database_cross_reference: MDR:10073194
database_cross_reference: MEDCIN:31389
database_cross_reference: MSH:D014526
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26904
database_cross_reference: NCI_NICHD:C26904
database_cross_reference: NDFRT:N0000003076
database_cross_reference: RCD:K17y0
database_cross_reference: RCD:X30Ox
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D7-23100
database_cross_reference: SNOMEDCT_US:197905005
database_cross_reference: SNOMEDCT_US:31822004

bejel
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results in infection located in mucosa of mouth, located in skin or located in bone, has material basis in Treponema pallidum subsp endemicum, which is transmitted by contact or transmitted by sharing of domestic utensils. The infection has symptom moist patches in the mouth, has symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.
PMOID: PMO:00029476
Subclass_of: primary bacterial infectious disease
Synonym: BEJEL
Synonym: Bejel
Synonym: Bejel (diagnosis)
Synonym: Bejel (disorder)
Synonym: Bejels
Synonym: Endemic syphilis
Synonym: Njovera
Synonym: Non-venereal syphilis
Synonym: Nonvenereal endemic syphilis
Synonym: Nonvenereal endemic syphilis (& [Bejel] or [Njovera])
Tree Number: T10.7.3.1.3
database_cross_reference: CHV:0000001762
database_cross_reference: DO:DOID:13431
database_cross_reference: DXP:U000200
database_cross_reference: LCH:U000525
database_cross_reference: MEDCIN:31084
database_cross_reference: MSH:D014211
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X70Q9
database_cross_reference: SNM:D-0114
database_cross_reference: SNOMEDCT_US:186978001
database_cross_reference: SNOMEDCT_US:240686008

glanders
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results in septicemic infection, has material basis in Burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.
PMOID: PMO:00029577
Subclass_of: primary bacterial infectious disease
Synonym: E-11B GLANDERS AND PSEUDOGLANDERS
Synonym: Equina
Synonym: Equine glanders
Synonym: FARCY
Synonym: Farcy
Synonym: Farcy buds
Synonym: Farcy cords
Synonym: Farcy pipes
Synonym: GLANDERS
Synonym: GLANDERS AND PSEUDOGLANDERS
Tree Number: T10.7.3.1.33
database_cross_reference: CHV:0000005509
database_cross_reference: DO:DOID:13444
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000715
database_cross_reference: ICD10:A24.0
database_cross_reference: ICD10AM:A24.0
database_cross_reference: ICD10CM:A24.0
database_cross_reference: ICD9CM:024
database_cross_reference: ICPC2P:A78014
database_cross_reference: LCH:U001970
database_cross_reference: LCH_NW:sh85055089
database_cross_reference: MDR:10018298
database_cross_reference: MEDCIN:219939
database_cross_reference: MEDCIN:219940
database_cross_reference: MEDCIN:31458
database_cross_reference: MEDCIN:31459
database_cross_reference: MEDCIN:97364
database_cross_reference: MEDCIN:97365
database_cross_reference: MEDCIN:97366
database_cross_reference: MSH:D005896
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:024
database_cross_reference: NCI:C34638
database_cross_reference: NCI_NICHD:C34638
database_cross_reference: NDFRT:N0000001344
database_cross_reference: RCD:A24..
database_cross_reference: SNM:D-0130
database_cross_reference: SNMI:DE-11B00
database_cross_reference: SNMI:DE-11B10
database_cross_reference: SNOMEDCT_US:35322000
database_cross_reference: SNOMEDCT_US:4639008

urethral intrinsic sphincter deficiency
type: Class
subclass of: urethral disease
PMOID: PMO:00032967
Subclass_of: urethral disease
Synonym: ISD
Synonym: Intrinsc sphnctr dficncy
Synonym: Intrinsic
Synonym: Intrinsic (urethral) sphincter deficiency (isd)
Synonym: Intrinsic (urethral) sphincter deficiency [ISD]
Synonym: Intrinsic sphincter deficiency
Synonym: Intrinsic sphincter deficiency (ISD)
Synonym: Intrinsic urethral sphincter deficiency
Synonym: Urethral intrinsic sphincter deficiency
Synonym: Urethral intrinsic sphincter deficiency (finding)
Tree Number: T10.8.7.3.7
database_cross_reference: CHV:0000031692
database_cross_reference: DO:DOID:13461
database_cross_reference: ICD10CM:N36.42
database_cross_reference: ICD9CM:599.82
database_cross_reference: MDR:10022846
database_cross_reference: MDR:10046456
database_cross_reference: MEDCIN:95996
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:599.82
database_cross_reference: SNOMEDCT_US:16031000119101

Proteus syndrome
type: Class
subclass of: physical disorder
PMOID: PMO:00028265
Subclass_of: physical disorder
Synonym: ELATTOPROTEUS SYNDROME
Synonym: Elattoproteus syndrome
Synonym: GIGANTISM, PARTIAL, OF HANDS AND FEET, NEVI, HEMIHYPERTROPHY, AND MACROCEPHALY
Synonym: Gigantism, partial, of hands and feet, nevi, hemihypertrophy, and macrocephaly
Synonym: Hemihypertrophy and macrocephaly
Synonym: Macrocephaly mesodermal hamartoma spectrum
Synonym: Partial gigantism of hands and feet, nevi, hemihypertrophy, macrocephaly
Synonym: Wiedemann's syndrome
Tree Number: T10.4.11
database_cross_reference: DO:DOID:13482
database_cross_reference: MSH:C537716
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:176920

childhood disintegrative disease
type: Class
subclass of: pervasive developmental disorder
definition: A pervasive developmental disorder that is a rare condition characterized by late onset (>3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress.
PMOID: PMO:00028123
Subclass_of: pervasive developmental disorder
Synonym: CDD - Childhood disintegrative disorder
Synonym: Childhood Disintegrative Disorder
Synonym: Childhood disintegrative disor
Synonym: Childhood disintegrative disorder
Synonym: Childhood disintegrative disorder (disorder)
Synonym: Dementia infantalis
Synonym: Dementia infantilis
Synonym: Disintegrative psychosis
Synonym: Disintegrative psychosis NOS
Synonym: Disintegrative psychosis NOS (disorder)
Tree Number: T10.3.5.2.2
database_cross_reference: AOD:0000006547
database_cross_reference: AOD:0000023884
database_cross_reference: CHV:0000023729
database_cross_reference: DO:DOID:13487
database_cross_reference: ICD10CM:F84.3
database_cross_reference: ICD9CM:299.1
database_cross_reference: MDR:10008522
database_cross_reference: MDR:10012287
database_cross_reference: MDR:10013143
database_cross_reference: MDR:10019379
database_cross_reference: MDR:10037238
database_cross_reference: MEDCIN:38371
database_cross_reference: MTHICD9:299.1
database_cross_reference: NCI:C97164
database_cross_reference: NCI_NICHD:C97164
database_cross_reference: RCD:E141.
database_cross_reference: RCD:E141z
database_cross_reference: SNM:D-9182
database_cross_reference: SNMI:D9-18130
database_cross_reference: SNOMEDCT_US:191694008
database_cross_reference: SNOMEDCT_US:192584009
database_cross_reference: SNOMEDCT_US:71961003

urethral syndrome
type: Class
subclass of: urethral disease
PMOID: PMO:00032960
Subclass_of: urethral disease
Synonym: URETHRA SYNDROME
Synonym: Urethral syndrome
Synonym: Urethral syndrome (disorder)
Synonym: Urethral syndrome NOS
Synonym: Urethral syndrome NOS (disorder)
Synonym: Urethral syndrome, NOS
Synonym: Urethral syndrome, unspecified
Synonym: syndrome urethral
Synonym: urethra syndrome
Synonym: urethral syndrome (diagnosis)
Tree Number: T10.8.7.3.1
database_cross_reference: CCPSS:0035390
database_cross_reference: CHV:0000017566
database_cross_reference: DO:DOID:13498
database_cross_reference: ICD10:N34.3
database_cross_reference: ICD10AM:N34.3
database_cross_reference: ICD10CM:N34.3
database_cross_reference: ICD9CM:597.81
database_cross_reference: ICPC2P:U72003
database_cross_reference: MDR:10046477
database_cross_reference: MDR:10046478
database_cross_reference: MEDCIN:98698
database_cross_reference: RCD:K17y1
database_cross_reference: RCD:X30PC
database_cross_reference: SNMI:D7-23110
database_cross_reference: SNOMEDCT_US:155893003
database_cross_reference: SNOMEDCT_US:197906006
database_cross_reference: SNOMEDCT_US:266633007
database_cross_reference: SNOMEDCT_US:31273004

loiasis
type: Class
subclass of: skin disease
definition: A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.
PMOID: PMO:00029656
Subclass_of: skin disease
Synonym: CALABAR SWELLINGS
Synonym: Calabar swelling
Synonym: Calabar swelling (disorder)
Synonym: calabar swelling
Synonym: calabar swelling (physical finding)
Tree Number: T10.8.12.2.35
database_cross_reference: DO:DOID:13523
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:B74.3
database_cross_reference: MEDCIN:6295
database_cross_reference: RCD:X70Tt
database_cross_reference: SNOMEDCT_US:240843005

hyperparathyroidism
type: Class
subclass of: parathyroid gland disease
definition: A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body.
PMOID: PMO:00033109
Subclass_of: parathyroid gland disease
Synonym: Elevated blood parathyroid hormone level
Synonym: HPTH - Hyperparathyroidism
Synonym: HYPERPARATHYROIDISM
Synonym: Hyperparathyroidism
Synonym: Hyperparathyroidism (disorder)
Synonym: Hyperparathyroidism NOS
Synonym: Hyperparathyroidism [Disease/Finding]
Synonym: Hyperparathyroidism, NOS
Synonym: Hyperparathyroidism, unspecified
Synonym: PARATHYROID, HYPERFUNCTION
Tree Number: T10.8.8.1.2
database_cross_reference: AOD:0000005995
database_cross_reference: BI:BI00349
database_cross_reference: CHV:0000006432
database_cross_reference: COSTAR:396
database_cross_reference: CSP:2216-0087
database_cross_reference: CST:PARATHYR DIS
database_cross_reference: DO:DOID:13543
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002030
database_cross_reference: HPO:HP:0000843
database_cross_reference: ICD10:E21.3
database_cross_reference: ICD10AM:E21.3
database_cross_reference: ICD10CM:E21.3
database_cross_reference: ICD9CM:252.0
database_cross_reference: ICD9CM:252.00
database_cross_reference: ICPC2P:T99037
database_cross_reference: LCH:U002313
database_cross_reference: LCH_NW:sh85063715
database_cross_reference: MDR:10020705
database_cross_reference: MDR:10020706
database_cross_reference: MEDCIN:30459
database_cross_reference: MEDLINEPLUS:356
database_cross_reference: MSH:D006961
database_cross_reference: NCI:C48259
database_cross_reference: NCI_CTCAE:E10319
database_cross_reference: NCI_NCI-GLOSS:CDR0000458097
database_cross_reference: NCI_NICHD:C48259
database_cross_reference: NDFRT:N0000001604
database_cross_reference: OMIM:MTHU036868
database_cross_reference: PSY:23790
database_cross_reference: RCD:XE10M
database_cross_reference: SNM:D-2261
database_cross_reference: SNMI:DB-90100
database_cross_reference: SNOMEDCT_US:154696001
database_cross_reference: SNOMEDCT_US:190451000
database_cross_reference: SNOMEDCT_US:66999008

campylobacteriosis
type: Class
subclass of: gastroenteritis
definition: A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever.
PMOID: PMO:00033522
Subclass_of: gastroenteritis
Synonym: CAMPYLOBACTER INFECT
Synonym: CAMPYLOBACTERIOSES
Synonym: Campylobacter Infection
Synonym: Campylobacter Infections
Synonym: Campylobacter Infections [Disease/Finding]
Synonym: Campylobacter infection
Synonym: Campylobacter infections
Synonym: Campylobacteriosis
Synonym: Campylobacteriosis (disorder)
Synonym: Campylobacteriosis, NOS
Tree Number: T10.8.11.5.2
database_cross_reference: CHV:0000002333
database_cross_reference: DO:DOID:13622
database_cross_reference: LCH:U000760
database_cross_reference: LCH_NW:sh85019266
database_cross_reference: MDR:10051226
database_cross_reference: MDR:10053136
database_cross_reference: MEDLINEPLUS:6046
database_cross_reference: MSH:D002169
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000649
database_cross_reference: RCD:XE0Ql
database_cross_reference: SNMI:DE-15300
database_cross_reference: SNOMEDCT_US:86500004
database_cross_reference: SNOMEDCT_VET:86500004

SAPHO syndrome
type: Class
subclass of: syndrome
PMOID: PMO:00025123
Subclass_of: syndrome
Synonym: Acquired Hyperostosis Syndrome
Synonym: Acquired Hyperostosis Syndrome [Disease/Finding]
Synonym: Acquired Hyperostosis Syndromes
Synonym: Hyperostosis Syndrome, Acquired
Synonym: Hyperostosis Syndromes, Acquired
Synonym: PPHS
Synonym: Pustulo-Psoriatic Hyperostotic Spondyloarthritis
Synonym: SAPHO - Synov,acne,pustul palm,hyperos,osteomyel syndrome
Synonym: SAPHO - Synovitis, acne, pustulosis palmaris, hyperostosis, osteomyelitis syndrome
Synonym: SAPHO Syndrome
Tree Number: T10.1.8
database_cross_reference: CHV:0000025643
database_cross_reference: DO:DOID:13677
database_cross_reference: MDR:10051316
database_cross_reference: MEDCIN:354765
database_cross_reference: MSH:D020083
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C119049
database_cross_reference: NCI:C84530
database_cross_reference: NCI_NICHD:C119049
database_cross_reference: NDFRT:N0000003993
database_cross_reference: RCD:X702V
database_cross_reference: SNMI:D1-233A0
database_cross_reference: SNOMEDCT_US:203140009
database_cross_reference: SNOMEDCT_US:60684003

prostate calculus
type: Class
subclass of: lower urinary tract calculus
PMOID: PMO:00032983
Subclass_of: lower urinary tract calculus
Synonym: Calculus of prostate
Synonym: Calculus of prostate (disorder)
Synonym: Calculus prostatic
Synonym: Calculus;prostate
Synonym: PROSTATE, CALCULUS
Synonym: PROSTATIC CALCULUS
Synonym: Prostate Calculus
Synonym: Prostatic Stone
Synonym: Prostatic calculus
Synonym: Prostatic lithiasis
Tree Number: T10.8.7.7.3
database_cross_reference: CHV:0000016606
database_cross_reference: COSTAR:U000511
database_cross_reference: DO:DOID:13689
database_cross_reference: DXP:U001594
database_cross_reference: ICD10:N42.0
database_cross_reference: ICD10AM:N42.0
database_cross_reference: ICD10CM:N42.0
database_cross_reference: ICD9CM:602.0
database_cross_reference: ICPC2P:Y99001
database_cross_reference: MDR:10007017
database_cross_reference: MDR:10007019
database_cross_reference: MDR:10036945
database_cross_reference: MEDCIN:34196
database_cross_reference: MTHICD9:602.0
database_cross_reference: NCI:C26936
database_cross_reference: RCD:K220.
database_cross_reference: SNMI:D7-51223
database_cross_reference: SNMI:D7-51224
database_cross_reference: SNOMEDCT_US:155934005
database_cross_reference: SNOMEDCT_US:85324003
database_cross_reference: SNOMEDCT_US:95592006

premature ejaculation
type: Class
subclass of: psychosexual disorder
PMOID: PMO:00028159
Subclass_of: psychosexual disorder
Synonym: EJACULATION PREMATURE
Synonym: Ejaculates too soon
Synonym: Ejaculatio Praecox
Synonym: Ejaculatio Praecoxs
Synonym: Ejaculatio praecox
Synonym: Ejaculation premature
Synonym: Ejaculation, Premature
Synonym: Ejaculation, premature
Synonym: Ejaculations, Premature
Synonym: Praecox, Ejaculatio
Tree Number: T10.3.11.4.1
database_cross_reference: AOD:0000006835
database_cross_reference: CHV:0000010083
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:EJACULAT ABNORM
database_cross_reference: DO:DOID:13709
database_cross_reference: DXP:U001095
database_cross_reference: HPO:HP:0012876
database_cross_reference: ICD10:F52.4
database_cross_reference: ICD10AM:F52.4
database_cross_reference: ICD10CM:F52.4
database_cross_reference: ICD9CM:302.75
database_cross_reference: ICPC2P:P08002
database_cross_reference: LCH_NW:sh88007626
database_cross_reference: MDR:10014330
database_cross_reference: MDR:10036596
database_cross_reference: MDR:10036597
database_cross_reference: MEDCIN:1142
database_cross_reference: MEDCIN:32825
database_cross_reference: MEDLINEPLUS:5571
database_cross_reference: MSH:D061686
database_cross_reference: NCI:C94349
database_cross_reference: NDFRT:N0000185609
database_cross_reference: PSY:40120
database_cross_reference: RCD:E2276
database_cross_reference: SNM:F-98160
database_cross_reference: SNMI:F-9B963
database_cross_reference: SNOMEDCT_US:123302009
database_cross_reference: SNOMEDCT_US:154905005
database_cross_reference: SNOMEDCT_US:192468006
database_cross_reference: SNOMEDCT_US:268762007
database_cross_reference: SNOMEDCT_US:44001008

neonatal urinary tract infectious disease
type: Class
subclass of: urinary system disease
PMOID: PMO:00033086
Subclass_of: urinary system disease
Synonym: NB urinary tract infectn
Synonym: Neonatal urinary tract infect.
Synonym: Neonatal urinary tract infection
Synonym: Neonatal urinary tract infection (disorder)
Synonym: URINARY TRACT INFECTION NEONATAL
Synonym: Urinary tract infection NOS neonatal
Synonym: Urinary tract infection neonatal
Synonym: Urinary tract infection of newborn
Synonym: urinary tract infection of newborn
Synonym: urinary tract infection of newborn (diagnosis)
Tree Number: T10.8.7.10
database_cross_reference: CST:INFECT URIN TRACT
database_cross_reference: DO:DOID:1375
database_cross_reference: ICD10:P39.3
database_cross_reference: ICD10AM:P39.3
database_cross_reference: ICD10CM:P39.3
database_cross_reference: ICD9CM:771.82
database_cross_reference: MDR:10046573
database_cross_reference: MDR:10046575
database_cross_reference: MEDCIN:272386
database_cross_reference: RCD:Q40y1
database_cross_reference: SNMI:D8-73300
database_cross_reference: SNOMEDCT_US:12301009

clonorchiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop.
PMOID: PMO:00029647
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection due to Clonorchis sinensis
Synonym: Oriental liver fluke disease
Tree Number: T10.7.4.1.25
database_cross_reference: DO:DOID:13767
database_cross_reference: ICD10CM:B66.1

opisthorchiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.
PMOID: PMO:00029626
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Opisthorchis
Tree Number: T10.7.4.1.9
database_cross_reference: DO:DOID:13768

plantar wart
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot.
PMOID: PMO:00029348
Subclass_of: viral infectious disease
Synonym: PLANTAR WART
Synonym: PLANTAR WARTS
Synonym: Plantar Wart
Synonym: Plantar Warts
Synonym: Plantar wart
Synonym: Plantar wart (disorder)
Synonym: Plantar warts
Synonym: VP - Verrucae pedis
Synonym: Verruca Plantaris
Synonym: Verruca pedis
Tree Number: T10.7.2.2
database_cross_reference: BI:BI00606
database_cross_reference: CHV:0000012964
database_cross_reference: COSTAR:587
database_cross_reference: COSTAR:U000537
database_cross_reference: DO:DOID:13775
database_cross_reference: ICD10CM:B07.0
database_cross_reference: ICD9CM:078.12
database_cross_reference: ICPC2P:S03002
database_cross_reference: ICPC2P:S03006
database_cross_reference: MDR:10035158
database_cross_reference: MEDCIN:31080
database_cross_reference: MEDLINEPLUS:459
database_cross_reference: MTH:587
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:078.12
database_cross_reference: NCI:C26913
database_cross_reference: NCI_NICHD:C26913
database_cross_reference: OMIM:MTHU042208
database_cross_reference: RCD:A7811
database_cross_reference: SNM:M-76630
database_cross_reference: SNMI:DE-32A13
database_cross_reference: SNOMEDCT_US:154363006
database_cross_reference: SNOMEDCT_US:63440008

chancroid
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in Haemophilus ducreyi, which is transmitted by sexual contact. The infection has symptom painful and soft ulcers.
PMOID: PMO:00029496
Subclass_of: primary bacterial infectious disease
Synonym: (Chancroid [& bubo]) or (Ducrey's chancre)
Synonym: (Chancroid [& bubo]) or (Ducrey's chancre) (disorder)
Synonym: Bubo chancroidal
Synonym: Bubo due to Haemophilus ducreyi
Synonym: Bubo due to Hemophilus ducreyi
Synonym: CHANCRE, SOFT
Synonym: CHANCROID
Synonym: Chancroid
Synonym: Chancroid (disorder)
Synonym: Chancroid (disorder) [Ambiguous]
Tree Number: T10.7.3.1.9
database_cross_reference: BI:BI00699
database_cross_reference: CCPSS:1017846
database_cross_reference: CHV:0000002718
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0715-7651
database_cross_reference: DO:DOID:13778
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000322
database_cross_reference: ICD10:A57
database_cross_reference: ICD10AM:A57
database_cross_reference: ICD10CM:A57
database_cross_reference: ICD9CM:099.0
database_cross_reference: LCH:U000923
database_cross_reference: LCH_NW:sh85022494
database_cross_reference: LNC:LA10441-6
database_cross_reference: MDR:10008392
database_cross_reference: MDR:10018944
database_cross_reference: MDR:10018945
database_cross_reference: MDR:10060620
database_cross_reference: MDR:10060621
database_cross_reference: MEDCIN:334912
database_cross_reference: MSH:D002602
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:099.0
database_cross_reference: NDFRT:N0000000741
database_cross_reference: RCD:XE0S1
database_cross_reference: SNM:D-0117
database_cross_reference: SNMI:DE-11500
database_cross_reference: SNOMEDCT_US:154391003
database_cross_reference: SNOMEDCT_US:186945008
database_cross_reference: SNOMEDCT_US:266143009
database_cross_reference: SNOMEDCT_US:266213004
database_cross_reference: SNOMEDCT_US:87429008

inclusion conjunctivitis
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.
PMOID: PMO:00029604
Subclass_of: commensal bacterial infectious disease
Synonym: Blennorrhea, Inclusion
Synonym: Blennorrheas, Inclusion
Synonym: CONJUNCTIVITIS, CHLAMYDIA
Synonym: CONJUNCTIVITIS, INCLUSION
Synonym: Chlamydia conjunctivitis
Synonym: Chlamydial conjunctivitis
Synonym: Chlamydial conjunctivitis (disorder)
Synonym: Chronic conjunctivitis due to Chlamydia trachomatis
Synonym: Conjunctivitides, Inclusion
Synonym: Conjunctivitis chlamydial
Tree Number: T10.7.3.3.5
database_cross_reference: CHV:0000003289
database_cross_reference: CHV:0000030515
database_cross_reference: CSP:1114-8463
database_cross_reference: DO:DOID:13800
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000401
database_cross_reference: ICD10:A74.0
database_cross_reference: ICD10AM:A74.0
database_cross_reference: ICD10CM:A74.0
database_cross_reference: ICD9CM:077.0
database_cross_reference: ICPC2P:F70002
database_cross_reference: MDR:10010745
database_cross_reference: MDR:10021629
database_cross_reference: MDR:10053993
database_cross_reference: MDR:10062847
database_cross_reference: MEDCIN:30996
database_cross_reference: MEDCIN:36145
database_cross_reference: MSH:D003235
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:077.0
database_cross_reference: NDFRT:N0000000837
database_cross_reference: RCD:X00Zq
database_cross_reference: RCD:XE0RP
database_cross_reference: SNM:D-0320
database_cross_reference: SNMI:DE-21200
database_cross_reference: SNOMEDCT_US:111840005
database_cross_reference: SNOMEDCT_US:154370006
database_cross_reference: SNOMEDCT_US:186674002
database_cross_reference: SNOMEDCT_US:186733005
database_cross_reference: SNOMEDCT_US:231861005
database_cross_reference: SNOMEDCT_US:266109000
database_cross_reference: SNOMEDCT_US:266202002
database_cross_reference: SNOMEDCT_US:56009001

pharyngoconjunctival fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection located in pharynx or located in conjunctiva, has material basis in Human adenovirus 3 or has material basis in Human adenovirus 7, which are transmitted by droplet spread of respiratory secretions or transmitted by fomites. The infection has symptom fever, has symptom lymphadenopathy of the neck, and has symptom headache.
PMOID: PMO:00029402
Subclass_of: viral infectious disease
Synonym: Adeno pharygoconjunctival fev
Synonym: Adenoviral pharygoconjunctival fever
Synonym: Adenoviral pharyngoconjunctival fever
Synonym: Adenoviral pharyngoconjunctivitis
Synonym: Adenoviral pharyngoconjunctivitis (disorder)
Synonym: Fever, Pharyngo-Conjunctival
Synonym: PHARYNGOCONJUNCTIVAL FEVER
Synonym: Pharyngo Conjunctival Fever
Synonym: Pharyngo-Conjunctival Fever
Synonym: Pharyngoconjunct fever
Tree Number: T10.7.2.45
database_cross_reference: CHV:0000009585
database_cross_reference: DO:DOID:13801
database_cross_reference: DXP:U001481
database_cross_reference: ICD9CM:077.2
database_cross_reference: MDR:10034842
database_cross_reference: MEDCIN:31240
database_cross_reference: MSH:D000258
database_cross_reference: NCI:C34924
database_cross_reference: RCD:Xa97e
database_cross_reference: SNM:D-0448
database_cross_reference: SNMI:DE-31030
database_cross_reference: SNOMEDCT_US:70385007

lymphogranuloma venereum
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis.
PMOID: PMO:00029610
Subclass_of: commensal bacterial infectious disease
Synonym: BUBO, CLIMATIC
Synonym: Chlamydia trachomatis lymphadenitis
Synonym: Chlamydial lymphogranuloma (venereum)
Synonym: Climatic AND/OR tropical bubo
Synonym: Climatic or tropical bubo
Synonym: DURAND-NICOLAS-FAVRE DISEASE
Synonym: Durand-Nicolas-Favre disease
Synonym: E-214 LYMPHOGRANULOMA VENEREUM
Synonym: FAVRE-DURAND DISEASE
Synonym: FREI DISEASE
Tree Number: T10.7.3.3.10
database_cross_reference: CCPSS:1017968
database_cross_reference: CHV:0000007613
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0638-3112
database_cross_reference: DO:DOID:13819
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001120
database_cross_reference: DXP:U002474
database_cross_reference: ICD10:A55
database_cross_reference: ICD10AM:A55
database_cross_reference: ICD10CM:A55
database_cross_reference: ICD9CM:099.1
database_cross_reference: LCH:U002763
database_cross_reference: LCH_NW:sh85079151
database_cross_reference: MDR:10008547
database_cross_reference: MDR:10024410
database_cross_reference: MDR:10025297
database_cross_reference: MDR:10049604
database_cross_reference: MEDCIN:334911
database_cross_reference: MSH:D008219
database_cross_reference: MTHICD9:099.1
database_cross_reference: NCI:C26822
database_cross_reference: NDFRT:N0000001904
database_cross_reference: RCD:A991.
database_cross_reference: SNM:D-0322
database_cross_reference: SNMI:DE-21400
database_cross_reference: SNOMEDCT_US:154391003
database_cross_reference: SNOMEDCT_US:186946009
database_cross_reference: SNOMEDCT_US:266213004
database_cross_reference: SNOMEDCT_US:89427004

sweat gland disease
type: Class
subclass of: skin disease
PMOID: PMO:00033867
Subclass_of: skin disease
Synonym: 0-52 DISEASES OF THE SWEAT GLANDS
Synonym: DISEASES OF THE SWEAT GLANDS
Synonym: Disease of sweat glands
Synonym: Disease of sweat glands, NOS
Synonym: Disease, Sweat Gland
Synonym: Disease;sweat gland(s)
Synonym: Diseases, Sweat Gland
Synonym: Disorder of sweat gland
Synonym: Disorder of sweat gland (disorder)
Synonym: Disorder of sweat glands
Tree Number: T10.8.12.2.13
database_cross_reference: AOD:0000005249
database_cross_reference: CHV:0000011949
database_cross_reference: CSP:2716-7040
database_cross_reference: CST:SKIN/SWGL
database_cross_reference: CST:SWEAT
database_cross_reference: DO:DOID:1383
database_cross_reference: HPO:HP:0000971
database_cross_reference: ICD10:L74
database_cross_reference: ICD10:L74.9
database_cross_reference: ICD10AM:L74
database_cross_reference: ICD10AM:L74.9
database_cross_reference: ICD10CM:L74
database_cross_reference: ICD10CM:L74.9
database_cross_reference: ICD9CM:705
database_cross_reference: ICD9CM:705.9
database_cross_reference: ICPC2EENG:S92
database_cross_reference: ICPC2P:S92002
database_cross_reference: LCH_NW:sh85131027
database_cross_reference: MDR:10013359
database_cross_reference: MDR:10042653
database_cross_reference: MDR:10042654
database_cross_reference: MDR:10045827
database_cross_reference: MEDCIN:210875
database_cross_reference: MSH:D013543
database_cross_reference: MTHICD9:705.9
database_cross_reference: NDFRT:N0000002867
database_cross_reference: RCD:M25..
database_cross_reference: RCD:M25z.
database_cross_reference: SNMI:D0-52000
database_cross_reference: SNOMEDCT_US:156413000
database_cross_reference: SNOMEDCT_US:201209003
database_cross_reference: SNOMEDCT_US:88232005

hypoactive sexual desire disorder
type: Class
subclass of: psychosexual disorder
PMOID: PMO:00028162
Subclass_of: psychosexual disorder
Synonym: Hypoactiv sex desire disord
Synonym: Hypoactive Sexual Desire Disorder
Synonym: Hypoactive sex desire
Synonym: Hypoactive sexual desire disorder
Synonym: Hypoactive sexual desire disorder (disorder)
Synonym: Lack of erotic interest
Synonym: Lack of erotic interest (finding)
Synonym: Lack or loss of sexual desire
Synonym: Lack or loss of sexual desire (disorder)
Synonym: [X]Hypoactive sexual desire disorder
Tree Number: T10.3.11.4.4
database_cross_reference: AOD:0000006825
database_cross_reference: DO:DOID:13868
database_cross_reference: ICD10:F52.0
database_cross_reference: ICD10AM:F52.0
database_cross_reference: ICD10CM:F52.0
database_cross_reference: ICD9CM:302.71
database_cross_reference: MDR:10020933
database_cross_reference: MEDCIN:32821
database_cross_reference: MSH:D020018
database_cross_reference: NCI:C94337
database_cross_reference: PSY:23945
database_cross_reference: RCD:E2272
database_cross_reference: RCD:XE2bA
database_cross_reference: SNMI:D9-73511
database_cross_reference: SNOMEDCT_US:112096004
database_cross_reference: SNOMEDCT_US:192464008
database_cross_reference: SNOMEDCT_US:270903007
database_cross_reference: SNOMEDCT_US:78889008

hypolipoproteinemia
type: Class
subclass of: lipid metabolism disorder
PMOID: PMO:00029248
Subclass_of: lipid metabolism disorder
Synonym: ANALPHALIPOPROTEINEMIA
Synonym: Alpha High Density Lipoprotein Deficiency Disease
Synonym: Alphalipoproteinemia neuropathy
Synonym: Analphalipoproteinaemia
Synonym: Analphalipoproteinemia
Synonym: Analphalipoproteinemias
Synonym: Analphaliproteinaemia
Synonym: Analphaliproteinemia
Synonym: Cholesterol Thesaurismoses
Synonym: Cholesterol Thesaurismosis
Tree Number: T10.6.2.18.1
database_cross_reference: CCPSS:0007284
database_cross_reference: CHV:0000012029
database_cross_reference: CSP:1849-5194
database_cross_reference: DO:DOID:1387
database_cross_reference: DO:DOID:1388
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:E78.6
database_cross_reference: MDR:10051875
database_cross_reference: MEDCIN:33566
database_cross_reference: MSH:D013631
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85182
database_cross_reference: NDFRT:N0000002898
database_cross_reference: OMIM:107680
database_cross_reference: OMIM:205400
database_cross_reference: OMIM:600046
database_cross_reference: RCD:X40Vt
database_cross_reference: RCDAE:X40Vt
database_cross_reference: SNM:D-1369
database_cross_reference: SNMI:D6-60230
database_cross_reference: SNOMEDCT_US:15346004
database_cross_reference: SNOMEDCT_US:190783007

polyneuropathy
type: Class
subclass of: peripheral nervous system disease
definition: A peripheral system disease that is characterized by is damage affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, pins-and-needles, and burning pain.
PMOID: PMO:00030155
Subclass_of: peripheral nervous system disease
Synonym: POLYNEUROPATHY
Synonym: Polyneuropathies
Synonym: Polyneuropathies [Disease/Finding]
Synonym: Polyneuropathy
Synonym: Polyneuropathy (disorder)
Synonym: Polyneuropathy (multiple nerve disorder)
Synonym: Polyneuropathy NOS
Synonym: Polyneuropathy unspecified
Synonym: Polyneuropathy unspecified (disorder)
Synonym: Polyneuropathy, NOS
Tree Number: T10.8.2.4.8
database_cross_reference: CCPSS:0023786
database_cross_reference: CHV:0000017134
database_cross_reference: COSTAR:U000548
database_cross_reference: CST:NEUROPATHY
database_cross_reference: DO:DOID:1389
database_cross_reference: DXP:U003194
database_cross_reference: HPO:HP:0001271
database_cross_reference: ICD10:G62.9
database_cross_reference: ICD10AM:G62.9
database_cross_reference: ICD10CM:A69.22
database_cross_reference: ICD10CM:G62.9
database_cross_reference: MDR:10036105
database_cross_reference: MDR:10036118
database_cross_reference: MEDCIN:32275
database_cross_reference: MSH:D011115
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26951
database_cross_reference: NDFRT:N0000002456
database_cross_reference: OMIM:MTHU038003
database_cross_reference: RCD:F366.
database_cross_reference: RCD:Fyu7C
database_cross_reference: RCD:XaB3q
database_cross_reference: RCDSY:Fyu7C
database_cross_reference: SNMI:DA-40100
database_cross_reference: SNOMEDCT_US:155080009
database_cross_reference: SNOMEDCT_US:193166009
database_cross_reference: SNOMEDCT_US:193204000
database_cross_reference: SNOMEDCT_US:194530007
database_cross_reference: SNOMEDCT_US:267706009
database_cross_reference: SNOMEDCT_US:307326004
database_cross_reference: SNOMEDCT_US:42345000

white piedra
type: Class
subclass of: superficial mycosis
definition: A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Trichosporon beigelii. Infected hairs develop soft greyish-white nodules along the shaft.
PMOID: PMO:00029288
Subclass_of: superficial mycosis
Synonym: Piedra
Synonym: Piedra (disorder)
Synonym: Piedra [Disease/Finding]
Synonym: Piedras
Synonym: Steroid-modified tinea infection
Synonym: Tinea blanca
Synonym: White piedra
Synonym: black piedra
Synonym: piedra
Synonym: piedras
Tree Number: T10.7.1.1.3
database_cross_reference: CHV:0000009730
database_cross_reference: DO:DOID:0050133
database_cross_reference: DO:DOID:12711
database_cross_reference: DO:DOID:13902
database_cross_reference: MSH:D010854
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002400
database_cross_reference: SNM:D-0583
database_cross_reference: SNOMEDCT_US:154408001
database_cross_reference: SNOMEDCT_US:266218008
database_cross_reference: SNOMEDCT_US:402135006

lumbosacral plexus lesion
type: Class
subclass of: peripheral nervous system disease
PMOID: PMO:00029890
Subclass_of: peripheral nervous system disease
Synonym: Lumbosacral plex lesion
Synonym: Lumbosacral plexus lesion
Synonym: Lumbosacral plexus lesion (disorder)
Synonym: Lumbosacral plexus lesion, NOS
Synonym: Lumbosacral plexus lesions
Synonym: lumbosacral plexus lesion (diagnosis)
Tree Number: T10.8.2.4.1
database_cross_reference: DO:DOID:13913
database_cross_reference: ICD9CM:353.1
database_cross_reference: MDR:10025016
database_cross_reference: MDR:10025017
database_cross_reference: MEDCIN:32331
database_cross_reference: RCD:F331.
database_cross_reference: SNMI:DA-42030
database_cross_reference: SNOMEDCT_US:4062006

somatization disorder
type: Class
subclass of: somatoform disorder
definition: A somatoform disorder that involves persistently complaints of varied physical symptoms that have no identifiable physical origin.
PMOID: PMO:00028129
Subclass_of: somatoform disorder
Synonym: Briquet Syndrome
Synonym: Briquet syndrome
Synonym: Briquet's disorder
Synonym: Briquet's disorder (finding)
Synonym: Briquet's syndrome
Synonym: Briquet's syndrome (disorder)
Synonym: Briquets syndrome
Synonym: Disorder;somatisation
Synonym: Disorders, Somatization
Synonym: Polysomatising disorder
Tree Number: T10.3.6.4
database_cross_reference: AOD:0000006625
database_cross_reference: CCPSS:0037074
database_cross_reference: CHV:0000037744
database_cross_reference: COSTAR:694
database_cross_reference: DO:DOID:13918
database_cross_reference: DXP:U001758
database_cross_reference: ICD10:F45.0
database_cross_reference: ICD10AM:F45.0
database_cross_reference: ICD10CM:F45.0
database_cross_reference: ICD9CM:300.81
database_cross_reference: ICPC2EENG:P75
database_cross_reference: ICPC2P:P75016
database_cross_reference: MDR:10006368
database_cross_reference: MDR:10006369
database_cross_reference: MDR:10041318
database_cross_reference: MDR:10041319
database_cross_reference: MEDCIN:32793
database_cross_reference: MSH:D013001
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:300.81
database_cross_reference: PSY:48627
database_cross_reference: RCD:E20y0
database_cross_reference: SNM:F-95360
database_cross_reference: SNMI:D9-82050
database_cross_reference: SNMI:F-95270
database_cross_reference: SNOMEDCT_US:154892001
database_cross_reference: SNOMEDCT_US:191743005
database_cross_reference: SNOMEDCT_US:192431008
database_cross_reference: SNOMEDCT_US:397795007
database_cross_reference: SNOMEDCT_US:397826007
database_cross_reference: SNOMEDCT_US:397923000
database_cross_reference: SNOMEDCT_US:60368009
database_cross_reference: SNOMEDCT_US:9514005

amenorrhea
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is characterized by the absence of menstruation.
PMOID: PMO:00029840
Subclass_of: female reproductive system disease
Synonym: AMENORRHEA
Synonym: AMENORRHOEA
Synonym: Abnormal absence of menstruation
Synonym: Absence of menstruation
Synonym: Absence of menstruation, NOS
Synonym: Amenorrhea
Synonym: Amenorrhea (finding)
Synonym: Amenorrhea NOS
Synonym: Amenorrhea NOS (finding)
Synonym: Amenorrhea [Disease/Finding]
Tree Number: T10.8.1.4.17
database_cross_reference: BI:BI00368
database_cross_reference: CHV:0000000990
database_cross_reference: COSTAR:047
database_cross_reference: CSP:4001-0006
database_cross_reference: CST:AMENORRHEA
database_cross_reference: DO:DOID:13938
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000142
database_cross_reference: HPO:HP:0000141
database_cross_reference: ICD10:N91.2
database_cross_reference: ICD10AM:N91.2
database_cross_reference: ICD10AMAE:N91.2
database_cross_reference: ICD10CM:N91.2
database_cross_reference: ICD9CM:626.0
database_cross_reference: ICPC2P:X05001
database_cross_reference: LCH:U000184
database_cross_reference: LCH_NW:sh85004214
database_cross_reference: MDR:10000326
database_cross_reference: MDR:10001927
database_cross_reference: MDR:10001928
database_cross_reference: MDR:10001929
database_cross_reference: MDR:10027319
database_cross_reference: MEDCIN:35268
database_cross_reference: MEDLINEPLUS:325
database_cross_reference: MSH:D000568
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:626.0
database_cross_reference: NCI:C61443
database_cross_reference: NCI_NICHD:C61443
database_cross_reference: NDFRT:N0000000368
database_cross_reference: OMIM:MTHU012513
database_cross_reference: PSY:02010
database_cross_reference: RCD:K590.
database_cross_reference: RCD:K590z
database_cross_reference: RCDAE:K590.
database_cross_reference: RCDAE:K590z
database_cross_reference: SNM:F-30090
database_cross_reference: SNMI:F-81100
database_cross_reference: SNOMEDCT_US:14302001
database_cross_reference: SNOMEDCT_US:156034000
database_cross_reference: SNOMEDCT_US:156037007
database_cross_reference: SNOMEDCT_US:198414005

urinary schistosomiasis
type: Class
subclass of: urinary system disease
definition: A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.
PMOID: PMO:00029630
Subclass_of: urinary system disease
Synonym: Schistosoma Hematobium Infection
Synonym: Schistosoma haematobium
Synonym: Schistosoma hematobium infectious disease
Synonym: Schistosomiasis due to schistosoma haematobium
Synonym: Schistosomiasis of bladder
Synonym: Vesical schistosomiasis
Synonym: bladder Schistosomiasis
Synonym: cystitis with bilharziasis
Tree Number: T10.8.7.1
database_cross_reference: DO:DOID:1394

bladder neck obstruction
type: Class
subclass of: bladder disease
PMOID: PMO:00033088
Subclass_of: bladder disease
Synonym: BLADDER NECK URINARY OBSTRUCTION
Synonym: BLADDER URINARY OBSTRUCTION
Synonym: BNO - Bladder neck obstruction
Synonym: Bladder Neck Obstruction
Synonym: Bladder Obstruction
Synonym: Bladder Outlet Obstruction
Synonym: Bladder neck obstruction
Synonym: Bladder neck obstruction (disorder)
Synonym: Bladder neck obstruction, NOS
Synonym: Bladder obstruction
Tree Number: T10.8.7.11.1
database_cross_reference: CCPSS:0049179
database_cross_reference: CCPSS:0061009
database_cross_reference: CHV:0000001955
database_cross_reference: CST:STENO BLADDER
database_cross_reference: DO:DOID:13948
database_cross_reference: ICD10:N32.0
database_cross_reference: ICD10AM:N32.0
database_cross_reference: ICD10CM:N32.0
database_cross_reference: ICD9CM:596.0
database_cross_reference: ICPC2P:U99007
database_cross_reference: MDR:10005053
database_cross_reference: MDR:10005060
database_cross_reference: MDR:10005087
database_cross_reference: MDR:10029971
database_cross_reference: MDR:10046529
database_cross_reference: MDR:10071445
database_cross_reference: MEDCIN:276793
database_cross_reference: MEDCIN:30651
database_cross_reference: MSH:D001748
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:596.0
database_cross_reference: NCI:C79541
database_cross_reference: NCI_NICHD:C79541
database_cross_reference: NDFRT:N0000000563
database_cross_reference: RCD:XE0dr
database_cross_reference: SNM:M-34000
database_cross_reference: SNMI:D7-21400
database_cross_reference: SNOMEDCT_US:155887006
database_cross_reference: SNOMEDCT_US:197859007
database_cross_reference: SNOMEDCT_US:25220001
database_cross_reference: SNOMEDCT_US:399072004
database_cross_reference: SNOMEDCT_US:416991005

schistosomiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.
PMOID: PMO:00029629
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.12
database_cross_reference: DO:DOID:1395

peptic esophagitis
type: Class
subclass of: peptic ulcer disease
PMOID: PMO:00033437
Subclass_of: peptic ulcer disease
Synonym: ESOPHAGITIS REFLUX
Synonym: ESOPHAGITIS, REFLUX
Synonym: Esophagitides, Peptic
Synonym: Esophagitides, Reflux
Synonym: Esophagitis, Peptic
Synonym: Esophagitis, Peptic [Disease/Finding]
Synonym: Esophagitis, Reflux
Synonym: Peptic Esophagitides
Synonym: Peptic Esophagitis
Synonym: Peptic esophagitis
Tree Number: T10.8.11.1.7
database_cross_reference: BI:BI00245
database_cross_reference: CCPSS:0042080
database_cross_reference: CHV:0000004661
database_cross_reference: COSTAR:643
database_cross_reference: CSP:1248-5846
database_cross_reference: DO:DOID:13976
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD9CM:530.11
database_cross_reference: MDR:10038262
database_cross_reference: MDR:10038263
database_cross_reference: MSH:D004942
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:530.1
database_cross_reference: NDFRT:N0000001166
database_cross_reference: RCD:Xa1q7
database_cross_reference: RCDAE:Xa1q7
database_cross_reference: SNM:M-40040
database_cross_reference: SNMI:D5-30140
database_cross_reference: SNMI:D5-30142
database_cross_reference: SNOMEDCT_US:155673008
database_cross_reference: SNOMEDCT_US:196600005
database_cross_reference: SNOMEDCT_US:266498005
database_cross_reference: SNOMEDCT_US:54856001
database_cross_reference: SNOMEDCT_US:57643001

parasitic infectious disease
type: Class
subclass of: disease by infectious agent
definition: A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host.
PMOID: PMO:00029616
Subclass_of: disease by infectious agent
Synonym: Ectoparasitic disease
Synonym: Endophthalmitis, parasitic
Synonym: Parasitic Endophthalmitis
Synonym: Parasitic endophthal NOS
Synonym: Parasitic endophthalmitis
Synonym: Parasitic endophthalmitis (disorder)
Synonym: Parasitic endophthalmitis NOS
Synonym: Parasitic endophthalmitis NOS (disorder)
Synonym: Parasitic endophthalmitis, NOS
Synonym: Parasitic endophthalmitis, unspecified
Tree Number: T10.7.4
database_cross_reference: DO:DOID:1398
database_cross_reference: ICD10CM:H44.12
database_cross_reference: ICD9CM:360.13
database_cross_reference: MDR:10033912
database_cross_reference: MEDCIN:36427
database_cross_reference: NCI:C34587
database_cross_reference: RCD:F4012
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:DA-70160
database_cross_reference: SNOMEDCT_US:193273005
database_cross_reference: SNOMEDCT_US:57100005

toxic shock syndrome
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.
PMOID: PMO:00029606
Subclass_of: commensal bacterial infectious disease
Synonym: SHOCK TOX
Synonym: SYNDROME TOXIC SHOCK
Synonym: Shock Syndrome (TSS), Toxic
Synonym: Shock Syndrome, Toxic
Synonym: Shock Syndromes, Toxic
Synonym: Shock, Toxic
Synonym: Syndrome (TSS), Toxic Shock
Synonym: Syndrome toxic shock
Synonym: Syndrome, Toxic Shock
Synonym: Syndromes, Toxic Shock
Tree Number: T10.7.3.3.7
database_cross_reference: AOD:0000023179
database_cross_reference: CCPSS:0035855
database_cross_reference: CHV:0000042239
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0368-3426
database_cross_reference: CST:INFECT
database_cross_reference: DO:DOID:14115
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001889
database_cross_reference: ICD10:A48.3
database_cross_reference: ICD10AM:A48.3
database_cross_reference: ICD10CM:A48.3
database_cross_reference: ICD9CM:040.82
database_cross_reference: ICPC2P:A78050
database_cross_reference: MDR:10042852
database_cross_reference: MDR:10044248
database_cross_reference: MDR:10044249
database_cross_reference: MEDCIN:31365
database_cross_reference: MEDLINEPLUS:3210
database_cross_reference: MSH:D012772
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35498
database_cross_reference: NCI_FDA:2108
database_cross_reference: NCI_NICHD:C35498
database_cross_reference: RCD:A3Ay1
database_cross_reference: SNM:D-2437
database_cross_reference: SNOMEDCT_US:18504008

bacteriuria
type: Class
subclass of: urinary system disease
definition: A urinary system disease which consists of the presence of bacteria in urine.
PMOID: PMO:00032984
Subclass_of: urinary system disease
Synonym: BACTERIURIA
Synonym: Bacilluria
Synonym: Bacteria in urine
Synonym: Bacteriuria
Synonym: Bacteriuria (finding)
Synonym: Bacteriuria NOS
Synonym: Bacteriuria [Disease/Finding]
Synonym: Bacteriurias
Synonym: Urine bacteria test positive
Tree Number: T10.8.7.8
database_cross_reference: CCPSS:1008000
database_cross_reference: CHV:0000001677
database_cross_reference: CSP:3045-9976
database_cross_reference: DO:DOID:1412
database_cross_reference: DXP:U000339
database_cross_reference: HPO:HP:0012461
database_cross_reference: ICD10CM:R82.71
database_cross_reference: ICPC2P:U71003
database_cross_reference: MDR:10004056
database_cross_reference: MDR:10004059
database_cross_reference: MSH:D001437
database_cross_reference: NDFRT:N0000000525
database_cross_reference: RCD:XE0e1
database_cross_reference: SNM:F-66130
database_cross_reference: SNMI:F-73612
database_cross_reference: SNOMEDCT_US:61373006

Masters-Allen syndrome
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is characterized by an excessively mobile uterus secondary to lacerations of the broad and cardinal ligaments, specific tenderness with movement of the cervix and previous untoward obstetrics events, such as premature maternal voluntary efforts, precipate delivery, and forceps delivery.
PMOID: PMO:00029841
Subclass_of: female reproductive system disease
Synonym: Allen-Masters syndrome
Synonym: Broad lig laceration syndrome
Synonym: Broad ligament lacer syn
Synonym: Broad ligament laceration syndrome
Synonym: Broad ligament laceration syndrome (disorder)
Synonym: Ligamentum latum laceration syndrome
Synonym: allen master syndrome
Synonym: allen masters syndrome
Synonym: allen-masters syndrome
Synonym: laceration of broad ligament
Tree Number: T10.8.1.4.18
database_cross_reference: CHV:0000017154
database_cross_reference: DO:DOID:14133
database_cross_reference: ICD9CM:620.6
database_cross_reference: MDR:10006376
database_cross_reference: MEDCIN:35188
database_cross_reference: MTHICD9:620.6
database_cross_reference: RCD:K536.
database_cross_reference: SNM:D-2458
database_cross_reference: SNMI:D7-75510
database_cross_reference: SNOMEDCT_US:69186005

ureterolithiasis
type: Class
subclass of: ureteral disease
PMOID: PMO:00032974
Subclass_of: ureteral disease
Synonym: Calculus of ureter
Synonym: UERTEROLITHIASIS
Synonym: Ureteral calculus
Synonym: Ureteral stone
Synonym: Ureteric calculus
Synonym: Ureteric stone
Synonym: Ureteric stone (disorder)
Synonym: Ureterolithiases
Synonym: Ureterolithiasis
Synonym: Ureterolithiasis (disorder)
Tree Number: T10.8.7.5.3
database_cross_reference: CHV:0000012758
database_cross_reference: CHV:0000056480
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:14146
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD9CM:592.1
database_cross_reference: MDR:10077989
database_cross_reference: MEDCIN:30711
database_cross_reference: MSH:D053039
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:592.1
database_cross_reference: NCI:C114696
database_cross_reference: NDFRT:N0000181037
database_cross_reference: RCD:K121.
database_cross_reference: SNMI:D7-11931
database_cross_reference: SNOMEDCT_US:31054009
database_cross_reference: SNOMEDCT_US:95573009
database_cross_reference: SNOMEDCT_VET:31054009

frozen shoulder
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032297
Subclass_of: connective tissue disease
Synonym: Adhesions-capsulitis,shoulder
Synonym: Adhesive Capsulitides, Shoulder
Synonym: Adhesive Capsulitis of the Shoulder
Synonym: Adhesive Capsulitis, Shoulder
Synonym: Adhesive capsulit shlder
Synonym: Adhesive capsulitis of should
Synonym: Adhesive capsulitis of shoulder
Synonym: Adhesive capsulitis of shoulder (disorder)
Synonym: Adhesive capsulitis of the shoulder
Synonym: Adhesive capsulitis shoulder
Tree Number: T10.8.4.1.13
database_cross_reference: BI:BI00494
database_cross_reference: CCPSS:0042672
database_cross_reference: CHV:0000028380
database_cross_reference: COSTAR:U000302
database_cross_reference: DO:DOID:14188
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001737
database_cross_reference: ICD10:M75.0
database_cross_reference: ICD10AM:M75.0
database_cross_reference: ICD10CM:M75.0
database_cross_reference: ICD9CM:726.0
database_cross_reference: ICPC2P:L92010
database_cross_reference: MDR:10001286
database_cross_reference: MDR:10017391
database_cross_reference: MEDCIN:34451
database_cross_reference: MEDLINEPLUS:505
database_cross_reference: MSH:D002062
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:XE1FL
database_cross_reference: SNM:D-3303
database_cross_reference: SNMI:D1-30140
database_cross_reference: SNOMEDCT_US:156658000
database_cross_reference: SNOMEDCT_US:156664007
database_cross_reference: SNOMEDCT_US:202837002
database_cross_reference: SNOMEDCT_US:202847004
database_cross_reference: SNOMEDCT_US:268087008
database_cross_reference: SNOMEDCT_US:399114005
database_cross_reference: SNOMEDCT_US:8753005

dihydropyrimidine dehydrogenase deficiency
type: Class
subclass of: purine-pyrimidine metabolic disorder
definition: A purine-pyrimidine metabolic disorder that is an autosomal recessive metabolic disorder in which there is absent or significantly decreased activity of dihydropyrimidine dehydrogenase, an enzyme involved in the metabolism of uracil and thymine.
PMOID: PMO:00029164
Subclass_of: purine-pyrimidine metabolic disorder
Synonym: DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY
Synonym: DPD DEFICIENCY
Synonym: DPD Deficiencies
Synonym: DPD Deficiency
Synonym: DPD deficiency
Synonym: DPYD DEFICIENCY
Synonym: Deficiencies, DPD
Synonym: Deficiencies, Dihydropyrimidine Dehydrogenase
Synonym: Deficiency, DPD
Synonym: Deficiency, Dihydropyrimidine Dehydrogenase
Tree Number: T10.6.2.14.2
database_cross_reference: DO:DOID:14218
database_cross_reference: HPO:HP:0003654
database_cross_reference: MDR:10052622
database_cross_reference: MDR:10075669
database_cross_reference: MEDCIN:314744
database_cross_reference: MSH:D054067
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3964
database_cross_reference: NCI:C84672
database_cross_reference: NDFRT:N0000181263
database_cross_reference: OMIM:274270
database_cross_reference: OMIM:612779
database_cross_reference: RCD:X40Ur
database_cross_reference: SNMI:D6-44230
database_cross_reference: SNOMEDCT_US:238016000
database_cross_reference: SNOMEDCT_US:77365006

ochronosis
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032028
Subclass_of: connective tissue disease
Synonym: Ochronoses
Synonym: Ochronosis
Synonym: Ochronosis (disorder)
Synonym: Ochronosis [Disease/Finding]
Synonym: ochronoses
Synonym: ochronosis (diagnosis)
Tree Number: T10.8.4.1.3
database_cross_reference: CHV:0000008888
database_cross_reference: DO:DOID:14223
database_cross_reference: HPO:HP:0030764
database_cross_reference: ICD10CM:E70.29
database_cross_reference: MDR:10051253
database_cross_reference: MEDCIN:97089
database_cross_reference: MSH:D009794
database_cross_reference: MTHICD9:270.2
database_cross_reference: NCI:C84938
database_cross_reference: NDFRT:N0000002206
database_cross_reference: SNM:D-1748
database_cross_reference: SNMI:D6-A2182
database_cross_reference: SNOMEDCT_US:21924005
database_cross_reference: SNOMEDCT_US:410042009

pyoureter
type: Class
subclass of: ureteral disease
PMOID: PMO:00032975
Subclass_of: ureteral disease
Synonym: PYOURETER
Synonym: Pyoureter
Synonym: Pyoureter (disorder)
Synonym: Ureter Abscess
Synonym: Ureter abscess
Synonym: Ureter abscess NOS
Synonym: pyoureter (diagnosis)
Tree Number: T10.8.7.5.5
database_cross_reference: DO:DOID:1425
database_cross_reference: DXP:U001637
database_cross_reference: MDR:10051347
database_cross_reference: MDR:10058706
database_cross_reference: MDR:10061395
database_cross_reference: MEDCIN:355633
database_cross_reference: NCI:C35666
database_cross_reference: SNM:M-40460
database_cross_reference: SNMI:D7-11980
database_cross_reference: SNOMEDCT_US:266627003
database_cross_reference: SNOMEDCT_US:85884009

Down syndrome
type: Class
subclass of: chromosomal disease
definition: A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability.
PMOID: PMO:00028828
Subclass_of: chromosomal disease
Synonym: 21 trisomies
Synonym: 21 trisomy
Synonym: 47,XX,+21
Synonym: 47,XY,+21
Synonym: Chromosomal imbalance syndrome, pair 21, trisomy
Synonym: Chromosome 21 trisomy
Synonym: Complete Trisomy 21 Syndrome
Synonym: Complete trisomy 21 syndrome
Synonym: Complete trisomy 21 syndrome (disorder)
Synonym: DOWN SYNDROME
Tree Number: T10.5.9.9
database_cross_reference: AOD:0000005004
database_cross_reference: AOD:0000023258
database_cross_reference: CCPSS:0037265
database_cross_reference: CHV:0000004101
database_cross_reference: COSTAR:U000198
database_cross_reference: CSP:1254-8068
database_cross_reference: CST:MENTAL RETARD
database_cross_reference: DO:DOID:14250
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000489
database_cross_reference: DXP:U000991
database_cross_reference: ICD10:Q90
database_cross_reference: ICD10:Q90.9
database_cross_reference: ICD10AM:Q90
database_cross_reference: ICD10AM:Q90.9
database_cross_reference: ICD10CM:Q90
database_cross_reference: ICD10CM:Q90.9
database_cross_reference: ICD9CM:758.0
database_cross_reference: ICPC2P:A90001
database_cross_reference: ICPC2P:A90004
database_cross_reference: JABL:203
database_cross_reference: LCH:U001453
database_cross_reference: LCH_NW:sh85039232
database_cross_reference: LNC:LA20088-3
database_cross_reference: LNC:LP19800-9
database_cross_reference: LNC:LP70386-5
database_cross_reference: LNC:MTHU010201
database_cross_reference: LNC:MTHU020584
database_cross_reference: MDR:10013616
database_cross_reference: MDR:10027816
database_cross_reference: MDR:10042801
database_cross_reference: MDR:10044688
database_cross_reference: MEDCIN:30421
database_cross_reference: MEDLINEPLUS:217
database_cross_reference: MSH:D004314
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:758.0
database_cross_reference: NCI:C101222
database_cross_reference: NCI:C2993
database_cross_reference: NCI_NCI-GLOSS:CDR0000045488
database_cross_reference: NCI_NICHD:C101222
database_cross_reference: NCI_NICHD:C2993
database_cross_reference: NDFRT:N0000000996
database_cross_reference: OMIM:190685
database_cross_reference: PSY:15020
database_cross_reference: PSY:31880
database_cross_reference: PSY:54340
database_cross_reference: RCD:X78Ek
database_cross_reference: RCD:XE1MZ
database_cross_reference: SNM:D-5712
database_cross_reference: SNMI:D4-02214
database_cross_reference: SNOMEDCT_US:157019002
database_cross_reference: SNOMEDCT_US:205614001
database_cross_reference: SNOMEDCT_US:205618003
database_cross_reference: SNOMEDCT_US:254263008
database_cross_reference: SNOMEDCT_US:41040004

ureteral disease
type: Class
subclass of: urinary system disease
definition: A urinary system disease that is located_in the ureter.
PMOID: PMO:00032971
Subclass_of: urinary system disease
Synonym: Disease, Ureteral
Synonym: Diseases, Ureteral
Synonym: URETERAL DIS
Synonym: Ureter Disease
Synonym: Ureteral Disease
Synonym: Ureteral Diseases
Synonym: Ureteral Diseases [Disease/Finding]
Synonym: Ureteral Diseases and Syndromes
Synonym: Ureteral disease or syndrome
Synonym: Ureteric Disease
Tree Number: T10.8.7.5
database_cross_reference: DO:DOID:1426
database_cross_reference: LCH_NW:sh85141374
database_cross_reference: MSH:D014515
database_cross_reference: NCI:C27148
database_cross_reference: NDFRT:N0000003068
database_cross_reference: SNM:D-6790
database_cross_reference: SNM:NOCODE

fragile X syndrome
type: Class
subclass of: X-linked disease
definition: An X-linked disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has material basis in X-linked inheritance and a loss of FMR1 function.
PMOID: PMO:00028721
Subclass_of: X-linked disease
Synonym: Escalante syndrome
Synonym: FRAGILE X MENTAL RETARDATION SYNDROME
Synonym: FRAGILE X SYNDROME
Synonym: FRAXA - Fragile X syndrome
Synonym: FXS
Synonym: Fra(X) Syndrome
Synonym: Fragile X Mental Retardation Syndrome
Synonym: Fragile X Syndrome
Synonym: Fragile X Syndrome [Disease/Finding]
Synonym: Fragile X Syndromes
Tree Number: T10.5.3.4.1
database_cross_reference: CHV:0000005246
database_cross_reference: CSP:1254-8431
database_cross_reference: DO:DOID:14261
database_cross_reference: ICD10CM:Q99.2
database_cross_reference: ICD9CM:759.83
database_cross_reference: JABL:215
database_cross_reference: LCH:U001873
database_cross_reference: LCH_NW:sh85051162
database_cross_reference: MDR:10017324
database_cross_reference: MEDCIN:38282
database_cross_reference: MEDLINEPLUS:3690
database_cross_reference: MSH:D005600
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84717
database_cross_reference: NDFRT:N0000001290
database_cross_reference: OMIM:300624
database_cross_reference: OMIM:309550
database_cross_reference: PSY:20295
database_cross_reference: RCD:X78FB
database_cross_reference: SNMI:D4-00504
database_cross_reference: SNOMEDCT_US:390007001
database_cross_reference: SNOMEDCT_US:613003

endocrine pancreas disease
type: Class
subclass of: pancreas disease
PMOID: PMO:00033204
Subclass_of: pancreas disease
Synonym: Oth disord panc end secretion
Synonym: Other dis.int.pancreat.secret.
Synonym: Other disorder of pancreatic internal secretion NOS
Synonym: Other disorder of pancreatic internal secretion NOS (disorder)
Synonym: Other disorders of pancreatic endocrine secretion
Synonym: Other disorders of pancreatic endocrine secretion (disorder)
Synonym: Other disorders of pancreatic internal secretion
Synonym: Other disorders of pancreatic internal secretion (disorder)
Synonym: Pancreatic int. secretion NOS
Tree Number: T10.8.8.4.8
database_cross_reference: DO:DOID:1428
database_cross_reference: ICD10:E16
database_cross_reference: ICD10AM:E16
database_cross_reference: ICD10CM:E16
database_cross_reference: ICD9CM:251
database_cross_reference: MDR:10031992
database_cross_reference: RCD:C11..
database_cross_reference: RCD:X40Ie
database_cross_reference: RCD:XE10L
database_cross_reference: SNOMEDCT_US:190427005
database_cross_reference: SNOMEDCT_US:190450004
database_cross_reference: SNOMEDCT_US:237574003
database_cross_reference: SNOMEDCT_US:267385007

primary hypertrophic osteoarthropathy
type: Class
subclass of: syndrome
PMOID: PMO:00025245
Subclass_of: syndrome
Synonym: Autosomal Recessive Pachydermoperiostosis
Synonym: Clubbed nail pachydermoperiostosis
Synonym: Clubbed pachydermoperiostosis
Synonym: Friedrich-Erb-Arnold syndrome
Synonym: HYPERTROPHIC OSTEOARTHROPATHY, PRIMARY, AUTOSOMAL RECESSIVE, 1
Synonym: Hypertrophic Osteoarthropathy, Idiopathic
Synonym: Hypertrophic Osteoarthropathy, Primary
Synonym: Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive
Synonym: Idiopathic Hypertrophic Osteoarthropathy
Synonym: Marie-Bamberger syndrome, idiopathic
Tree Number: T10.1.105
database_cross_reference: DO:DOID:14283
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:L62.0
database_cross_reference: ICD10AM:L62.0
database_cross_reference: ICD10CM:M89.4
database_cross_reference: MDR:10051686
database_cross_reference: MEDCIN:33106
database_cross_reference: MSH:D010004
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85023
database_cross_reference: NDFRT:N0000002245
database_cross_reference: OMIM:259100
database_cross_reference: OMIM:601688
database_cross_reference: RCD:X50I8
database_cross_reference: SNM:D-3010
database_cross_reference: SNM:D-3013
database_cross_reference: SNM:D-3656
database_cross_reference: SNMI:D4-01121
database_cross_reference: SNOMEDCT_US:201124000
database_cross_reference: SNOMEDCT_US:223726008
database_cross_reference: SNOMEDCT_US:239052008
database_cross_reference: SNOMEDCT_US:88220006

generalized anxiety disorder
type: Class
subclass of: anxiety disorder
definition: An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.
PMOID: PMO:00028223
Subclass_of: anxiety disorder
Synonym: ANXIETY DISORDER GENERALIZED
Synonym: GAD
Synonym: GAD - General anxiety disorder
Synonym: GAD - Generalised anxiety disorder
Synonym: GAD - Generalized anxiety disorder
Synonym: GENERALIZED ANXIETY DISORDER
Synonym: Generalised anxiety disorder
Synonym: Generalised anxiety disorder (disorder)
Synonym: Generalised anxiety disorder [Ambiguous]
Synonym: Generalized Anxiety Disorder
Tree Number: T10.3.12.5.4
database_cross_reference: AOD:0000023902
database_cross_reference: CCPSS:0056029
database_cross_reference: CHV:0000026482
database_cross_reference: CHV:0000058153
database_cross_reference: DO:DOID:14320
database_cross_reference: DSM-5:300.02
database_cross_reference: DSM-5:F41.1
database_cross_reference: DXP:U000705
database_cross_reference: ICD10:F41.1
database_cross_reference: ICD10AM:F41.1
database_cross_reference: ICD10AMAE:F41.1
database_cross_reference: ICD10CM:F41.1
database_cross_reference: ICD9CM:300.02
database_cross_reference: MDR:10017571
database_cross_reference: MDR:10018075
database_cross_reference: MDR:10018105
database_cross_reference: MEDCIN:32777
database_cross_reference: MEDLINEPLUS:144
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92622
database_cross_reference: NCI_NCI-GLOSS:CDR0000476551
database_cross_reference: NCI_NCI-GLOSS:CDR0000558986
database_cross_reference: NCI_NICHD:C92622
database_cross_reference: PSY:20801
database_cross_reference: RCD:E2002
database_cross_reference: RCDAE:E2002
database_cross_reference: SNMI:D9-81010
database_cross_reference: SNOMEDCT_US:191706008
database_cross_reference: SNOMEDCT_US:192401002
database_cross_reference: SNOMEDCT_US:21897009

Marfan syndrome
type: Class
subclass of: connective tissue disease
definition: A connective tissue disease that is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and subluxation of the lens.
PMOID: PMO:00032318
Subclass_of: connective tissue disease
Synonym: MARFAN SYNDROME
Synonym: MARFAN SYNDROME, TYPE I
Synonym: MARFAN'S SYNDROME
Synonym: MFS
Synonym: MFS1
Synonym: Marfan Syndrome
Synonym: Marfan Syndrome [Disease/Finding]
Synonym: Marfan Syndrome, Type I
Synonym: Marfan's Syndrome
Synonym: Marfan's disease
Tree Number: T10.8.4.1.22
database_cross_reference: CCPSS:0063638
database_cross_reference: CHV:0000007748
database_cross_reference: COSTAR:U000435
database_cross_reference: CSP:1849-5992
database_cross_reference: DO:DOID:14323
database_cross_reference: DXP:U001138
database_cross_reference: DXP:U002507
database_cross_reference: ICD10:Q87.4
database_cross_reference: ICD10AM:Q87.4
database_cross_reference: ICD10CM:Q87.4
database_cross_reference: ICD10CM:Q87.40
database_cross_reference: ICD9CM:759.82
database_cross_reference: ICPC2P:A90003
database_cross_reference: LCH:U002816
database_cross_reference: LCH_NW:sh87000793
database_cross_reference: MDR:10026829
database_cross_reference: MEDCIN:30409
database_cross_reference: MEDLINEPLUS:939
database_cross_reference: MSH:D008382
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34807
database_cross_reference: NCI_NICHD:C34807
database_cross_reference: NDFRT:N0000001945
database_cross_reference: OMIM:134797
database_cross_reference: OMIM:154700
database_cross_reference: RCD:PKy2.
database_cross_reference: SNM:D-3850
database_cross_reference: SNMI:D6-90800
database_cross_reference: SNOMEDCT_US:157024004
database_cross_reference: SNOMEDCT_US:157033002
database_cross_reference: SNOMEDCT_US:19346006
database_cross_reference: SNOMEDCT_US:268359006

systemic primary carnitine deficiency disease
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves defective proteins called carnitine transporters, which bring carnitine into cells and prevent its escape from the body preventing the body cannot utilize fats for energy.
PMOID: PMO:00029176
Subclass_of: amino acid metabolic disorder
Synonym: CARNITINE DEFICIENCY, PRIMARY
Synonym: CARNITINE DEFICIENCY, SYSTEMIC PRIMARY
Synonym: CARNITINE DEFICIENCY, SYSTEMIC, DUE TO DEFECT IN RENAL REABSORPTION OF CARNITINE
Synonym: CARNITINE TRANSPORTER, PLASMA-MEMBRANE, DEFICIENCY OF
Synonym: CARNITINE UPTAKE DEFECT
Synonym: CDSP
Synonym: CUD
Synonym: Carnitine Deficiency
Synonym: Carnitine Transporter Deficiency
Synonym: Carnitine Uptake Deficiency
Tree Number: T10.6.2.15.5
database_cross_reference: CHV:0000030794
database_cross_reference: DO:DOID:14365
database_cross_reference: ICD10CM:E71.41
database_cross_reference: ICD9CM:277.81
database_cross_reference: LNC:LA12487-7
database_cross_reference: LNC:LA21163-3
database_cross_reference: LNC:LP56784-9
database_cross_reference: LNC:LP56994-4
database_cross_reference: LNC:MTHU021614
database_cross_reference: MEDCIN:272867
database_cross_reference: MSH:C536778
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98864
database_cross_reference: NCI_NICHD:C98864
database_cross_reference: OMIM:212140
database_cross_reference: OMIM:603377
database_cross_reference: RCD:X40UP
database_cross_reference: SNMI:D6-B7310
database_cross_reference: SNOMEDCT_US:21764004

pyuria
type: Class
subclass of: urinary system disease
PMOID: PMO:00032970
Subclass_of: urinary system disease
Synonym: Pus cells in urine
Tree Number: T10.8.7.4
database_cross_reference: DO:DOID:1439

dracunculiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.
PMOID: PMO:00029620
Subclass_of: parasitic helminthiasis infectious disease
Synonym: DRACONTIASIS
Synonym: DRACUNCULIASIS
Synonym: Disease, Guinea Worm
Synonym: Diseases, Guinea Worm
Synonym: Dracontiasis
Synonym: Dracontiasis - guinea-worm
Synonym: Dracunculiases
Synonym: Dracunculiasis
Synonym: Dracunculiasis [Disease/Finding]
Synonym: Dracunculoses
Tree Number: T10.7.4.1.3
database_cross_reference: CHV:0000004107
database_cross_reference: DO:DOID:14418
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000490
database_cross_reference: ICD10:B72
database_cross_reference: ICD10AM:B72
database_cross_reference: ICD10CM:B72
database_cross_reference: ICD9CM:125.7
database_cross_reference: LCH_NW:sh87007835
database_cross_reference: MDR:10013617
database_cross_reference: MDR:10013618
database_cross_reference: MEDCIN:31020
database_cross_reference: MSH:D004320
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:125.7
database_cross_reference: NCI:C84677
database_cross_reference: NCI_NICHD:C84677
database_cross_reference: NDFRT:N0000000997
database_cross_reference: RCD:AC57.
database_cross_reference: SNM:D-0681
database_cross_reference: SNMI:DE-69700
database_cross_reference: SNOMEDCT_US:396334002
database_cross_reference: SNOMEDCT_US:48874008

neuroleptic malignant syndrome
type: Class
subclass of: nervous system disease
definition: A nervous system disease that is characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness and is associated with administration of antipsychotic and other central dopaminergic blockers.
PMOID: PMO:00030167
Subclass_of: nervous system disease
Synonym: Malignant neuroleptic syndrome
Synonym: NEUROLEPTIC MALIGNANT SYNDROME
Synonym: NMS
Synonym: NMS (Neuroleptic Malignant Syndrome)
Synonym: NMS - Neuroleptic malignant syndrome
Synonym: NMSs (Neuroleptic Malignant Syndrome)
Synonym: Neuroleptic Malignant Syndrome
Synonym: Neuroleptic Malignant Syndrome [Disease/Finding]
Synonym: Neuroleptic Malignant Syndromes
Synonym: Neuroleptic malgnt synd
Tree Number: T10.8.2.6
database_cross_reference: CCPSS:0025241
database_cross_reference: CHV:0000008640
database_cross_reference: CST:NEUROLEPTIC MAL SYND
database_cross_reference: DO:DOID:14464
database_cross_reference: DSM-5:333.92
database_cross_reference: DSM-5:G21.0
database_cross_reference: ICD10:G21.0
database_cross_reference: ICD10AM:G21.0
database_cross_reference: ICD10CM:G21.0
database_cross_reference: ICD9CM:333.92
database_cross_reference: LCH_NW:sh89002389
database_cross_reference: MDR:10029281
database_cross_reference: MDR:10029282
database_cross_reference: MDR:10029435
database_cross_reference: MEDCIN:38660
database_cross_reference: MSH:D009459
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94829
database_cross_reference: NCI_NCI-GLOSS:CDR0000468792
database_cross_reference: NCI_NCI-GLOSS:CDR0000505987
database_cross_reference: NDFRT:N0000002172
database_cross_reference: PSY:33715
database_cross_reference: RCD:X003d
database_cross_reference: SNMI:D9-87110
database_cross_reference: SNOMEDCT_US:15244003
database_cross_reference: SNOMEDCT_US:192826000
database_cross_reference: SNOMEDCT_US:68977009

hantavirus pulmonary syndrome
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection located in lung, has material basis in Sin Nombre virus, transmitted by deer mouse (Myodes glareolus), has material basis in Black Creek Canal virus, transmitted by cotton rat (Sigmodon hispidus), has material basis in Bayou virus, transmitted by marsh rice rat (Oryzomys palustris), has material basis in Laguna Negra virus, transmitted by small vesper mouse (Calomys laucha), or has material basis in Andes virus, transmitted by rice rat (Oligoryzomys longicaudatus). The infection has symptom fever, has symptom muscle pain, has symptom headache, has symptom cough, has symptom vomiting, has symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.
PMOID: PMO:00029411
Subclass_of: viral infectious disease
Synonym: HANTAVIRUS PULM SYNDROME
Synonym: HARDS
Synonym: Hanta virus pulmonary syndrome
Synonym: Hantavirus Associated Respiratory Distress Syndrome
Synonym: Hantavirus Pulmonary Syndrome
Synonym: Hantavirus Pulmonary Syndrome [Disease/Finding]
Synonym: Hantavirus Pulmonary Syndromes
Synonym: Hantavirus disease pulmonary syndrome
Synonym: Hantavirus disease pulmonary syndrome (diagnosis)
Synonym: Hantavirus pulmonary infection
Tree Number: T10.7.2.48
database_cross_reference: DO:DOID:14472
database_cross_reference: LCH_NW:sh2005006237
database_cross_reference: LNC:LA10469-7
database_cross_reference: MDR:10019143
database_cross_reference: MDR:10019144
database_cross_reference: MDR:10056320
database_cross_reference: MEDCIN:278145
database_cross_reference: MSH:D018804
database_cross_reference: NCI:C84747
database_cross_reference: NCI_NICHD:C84747
database_cross_reference: NDFRT:N0000003860
database_cross_reference: SNOMEDCT_US:120639003

lipoid proteinosis
type: Class
subclass of: lipid metabolism disorder
PMOID: PMO:00029255
Subclass_of: lipid metabolism disorder
Synonym: HYALINOSIS CUTIS ET MUCOSAE
Synonym: Hyalinosis Cutis et Mucosae
Synonym: Hyalinosis cutis et mucosae
Synonym: LIPOID PROTEINOSIS
Synonym: LIPOID PROTEINOSIS OF URBACH AND WIETHE
Synonym: LIPOID PROTEINOSIS URBACH AND WIETHE
Synonym: LIPOPROTEINOSIS
Synonym: Lipid proteinosis
Synonym: Lipid proteinosis (disorder)
Synonym: Lipoid Proteinosis of Urbach and Wiethe
Tree Number: T10.6.2.18.2
database_cross_reference: CHV:0000007462
database_cross_reference: CHV:0000021363
database_cross_reference: DO:DOID:14498
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001600
database_cross_reference: MDR:10051661
database_cross_reference: MSH:D008065
database_cross_reference: NCI:C84829
database_cross_reference: NCI_CDISC:C84829
database_cross_reference: NDFRT:N0000001853
database_cross_reference: OMIM:247100
database_cross_reference: OMIM:602201
database_cross_reference: RCD:X50Fh
database_cross_reference: RCD:X50Fi
database_cross_reference: SNM:M-55650
database_cross_reference: SNMI:D6-64910
database_cross_reference: SNOMEDCT_US:238950006
database_cross_reference: SNOMEDCT_US:38692000
database_cross_reference: SNOMEDCT_VET:38692000

fucosidosis
type: Class
subclass of: lysosomal storage disease
PMOID: PMO:00029111
Subclass_of: lysosomal storage disease
Synonym: A-fucosidase deficiency
Synonym: ALPHA FUCOSIDASE DEFIC DIS
Synonym: ALPHA L FUCOSIDASE DEFIC DIS
Synonym: ALPHA-L-FUCOSIDASE DEFICIENCY
Synonym: Alpha-Fucosidase Deficiency
Synonym: Alpha-L-fucosidase deficiency
Synonym: Alpha-fucosidase deficiency
Synonym: DEFIC DIS ALPHA FUCOSIDASE
Synonym: DEFIC DIS ALPHA L FUCOSIDASE
Synonym: Deficiency Disease, Fucosidase
Tree Number: T10.6.2.8.8
database_cross_reference: CSP:1849-8519
database_cross_reference: DO:DOID:14500
database_cross_reference: ICD10CM:E77.1
database_cross_reference: JABL:306
database_cross_reference: MEDCIN:97087
database_cross_reference: MSH:D005645
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:271.8
database_cross_reference: NCI:C61274
database_cross_reference: NCI_NICHD:C61274
database_cross_reference: NDFRT:N0000001296
database_cross_reference: OMIM:230000
database_cross_reference: OMIM:612280
database_cross_reference: OMIM:MTHU012937
database_cross_reference: RCD:C31y1
database_cross_reference: SNM:D-1288
database_cross_reference: SNMI:D6-72300
database_cross_reference: SNOMEDCT_US:190937009
database_cross_reference: SNOMEDCT_US:64716005

WAGR syndrome
type: Class
subclass of: chromosomal deletion syndrome
definition: A chromosomal deletion syndrome that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.
PMOID: PMO:00028784
Subclass_of: chromosomal deletion syndrome
Synonym: 11p Partial Monosomy Syndrome
Synonym: 11p partial monosomy syndrome
Synonym: 11p partial monosomy syndrome (diagnosis)
Synonym: 11p partial monosomy syndrome (disorder)
Synonym: Aniridia-Wilms tumor association
Synonym: Aniridia-Wilms tumour association
Synonym: CHROMOSOME 11p13 DELETION SYNDROME
Synonym: Chromosome 11p13 Deletion Syndrome
Synonym: Chromosome 11p13 deletion syndrome
Synonym: Chromosome 11p13 deletion syndrome (disorder)
Tree Number: T10.5.9.8.7
database_cross_reference: DO:DOID:14515
database_cross_reference: MEDCIN:355851
database_cross_reference: MSH:D017624
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3718
database_cross_reference: NCI_NCI-GLOSS:CDR0000482350
database_cross_reference: NCI_NCI-GLOSS:CDR0000559084
database_cross_reference: NCI_NICHD:C3718
database_cross_reference: NDFRT:N0000003616
database_cross_reference: OMIM:194072
database_cross_reference: SNMI:D4-02112
database_cross_reference: SNOMEDCT_US:4135001
database_cross_reference: SNOMEDCT_US:715215007

Reye syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use.
PMOID: PMO:00025158
Subclass_of: syndrome
Synonym: FATTY LIVER WITH ENCEPHALOPATHY
Synonym: Fatty Liver with Encephalopathy
Synonym: REYE SYNDROME
Synonym: REYE'S SYNDROME
Synonym: REYES SYNDROME
Synonym: Reye Johnson Syndrome
Synonym: Reye Syndrome
Synonym: Reye Syndrome [Disease/Finding]
Synonym: Reye's Syndrome
Synonym: Reye's encephalopathy
Tree Number: T10.1.39
database_cross_reference: CCPSS:0049568
database_cross_reference: CHV:0000010830
database_cross_reference: CSP:0944-8104
database_cross_reference: CST:BRAIN SYND ACUTE
database_cross_reference: DO:DOID:14525
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001677
database_cross_reference: ICD10:G93.7
database_cross_reference: ICD10AM:G93.7
database_cross_reference: ICD10CM:G93.7
database_cross_reference: ICD9CM:331.81
database_cross_reference: LCH:U004114
database_cross_reference: LCH_NW:sh85113551
database_cross_reference: MDR:10039012
database_cross_reference: MDR:10039013
database_cross_reference: MDR:10042842
database_cross_reference: MEDCIN:30234
database_cross_reference: MEDLINEPLUS:385
database_cross_reference: MSH:D012202
database_cross_reference: NCI:C34983
database_cross_reference: NCI_NCI-GLOSS:CDR0000468795
database_cross_reference: NDFRT:N0000002624
database_cross_reference: OMIM:MTHU026240
database_cross_reference: RCD:F11y0
database_cross_reference: SNM:D-8832
database_cross_reference: SNMI:DA-20050
database_cross_reference: SNOMEDCT_US:154998003
database_cross_reference: SNOMEDCT_US:267688001
database_cross_reference: SNOMEDCT_US:74351001

disease of cellular proliferation
type: Class
subclass of: Disease
definition: A disease that is characterized by abnormally rapid cell division.
PMOID: PMO:00025250
Subclass_of: Disease
Synonym: cell process disease
Synonym: neoplasm
Tree Number: T10.2
database_cross_reference: DO:DOID:14566

hypothyroidism
type: Class
subclass of: thyroid gland disease
definition: A thyroid gland disease which involves an underproduction of thyroid hormone.
PMOID: PMO:00033169
Subclass_of: thyroid gland disease
Synonym: HYPOTHYROID
Synonym: HYPOTHYROIDISM
Synonym: Hypothyreosis
Synonym: Hypothyroid
Synonym: Hypothyroidism
Synonym: Hypothyroidism (disorder)
Synonym: Hypothyroidism NOS
Synonym: Hypothyroidism NOS (disorder)
Synonym: Hypothyroidism [Ambiguous]
Synonym: Hypothyroidism [Disease/Finding]
Tree Number: T10.8.8.3.5
database_cross_reference: AOD:0000005992
database_cross_reference: BI:BI00015
database_cross_reference: CCPSS:1001237
database_cross_reference: CCPSS:1017778
database_cross_reference: CHV:0000006501
database_cross_reference: COSTAR:404
database_cross_reference: CSP:2928-6836
database_cross_reference: CST:HYPOTHYR
database_cross_reference: DO:DOID:1459
database_cross_reference: DXP:U002059
database_cross_reference: HPO:HP:0000821
database_cross_reference: ICD10:E03.9
database_cross_reference: ICD10AM:E03.9
database_cross_reference: ICD10CM:E03.9
database_cross_reference: ICD9CM:244.9
database_cross_reference: ICPC2P:T86009
database_cross_reference: LCH:U002348
database_cross_reference: LCH_NW:sh85063828
database_cross_reference: LNC:LA14303-4
database_cross_reference: LNC:MTHU020783
database_cross_reference: MDR:10021114
database_cross_reference: MDR:10043686
database_cross_reference: MDR:10045920
database_cross_reference: MDR:10077221
database_cross_reference: MEDCIN:30524
database_cross_reference: MEDLINEPLUS:6175
database_cross_reference: MSH:D007037
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:244.9
database_cross_reference: NCI:C26800
database_cross_reference: NCI_CTCAE:E10334
database_cross_reference: NCI_NCI-GLOSS:CDR0000044547
database_cross_reference: NCI_NCI-GLOSS:CDR0000520362
database_cross_reference: NCI_NICHD:C26800
database_cross_reference: NDFRT:N0000001654
database_cross_reference: OMIM:MTHU002670
database_cross_reference: OMIM:MTHU025716
database_cross_reference: PDQ:CDR0000489292
database_cross_reference: PSY:24120
database_cross_reference: RCD:X40IQ
database_cross_reference: RCD:XE10A
database_cross_reference: SNM:D-2200
database_cross_reference: SNMI:DB-80400
database_cross_reference: SNOMEDCT_US:154660000
database_cross_reference: SNOMEDCT_US:190274003
database_cross_reference: SNOMEDCT_US:190290003
database_cross_reference: SNOMEDCT_US:237572004
database_cross_reference: SNOMEDCT_US:267377003
database_cross_reference: SNOMEDCT_US:267465007
database_cross_reference: SNOMEDCT_US:40930008

cholesterol embolism
type: Class
subclass of: vascular disease
definition: A vascular disease that is characterized by blood vessel obstruction resulting from the release of cholesterol from the inside of blood vessels along the bloodstream.
PMOID: PMO:00031824
Subclass_of: vascular disease
Synonym: Atheroembolism
Synonym: Atheroembolisms
Synonym: Atheromatous embolus
Synonym: Atheromatous embolus (morphologic abnormality)
Synonym: CHOLESTEROL EMBOLISM
Synonym: Cholesterol Embolism
Synonym: Cholesterol Embolisms
Synonym: Cholesterol embolus
Synonym: Embolism, Cholesterol
Synonym: Embolism, Cholesterol [Disease/Finding]
Tree Number: T10.8.3.3.2
database_cross_reference: CHV:0000016639
database_cross_reference: COSTAR:U000133
database_cross_reference: DO:DOID:1461
database_cross_reference: ICD10CM:I75
database_cross_reference: ICD9CM:445
database_cross_reference: LCH_NW:sh85009128
database_cross_reference: MEDCIN:272299
database_cross_reference: MSH:D017700
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003627
database_cross_reference: SNM:M-35360
database_cross_reference: SNMI:M-35360
database_cross_reference: SNOMEDCT_US:10690002

VACTERL association
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by the presence of at least three of the following: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities.
PMOID: PMO:00025180
Subclass_of: syndrome
Synonym: VATER Association
Synonym: VATER anomalad
Synonym: VATER association
Synonym: VATER association (disorder)
Synonym: VATER association [dup] (disorder)
Synonym: VATER syndrome
Synonym: Vater association
Synonym: Vater association (diagnosis)
Synonym: Vertebral anomalies/dysgenesis, anal atresia, tracheo-esophageal fistula, esophageal atresia, renal anomalies, radial dysplasia (VATER) association
Synonym: Vertebral anomalies/dysgenesis, anal atresia, tracheo-esophageal fistula, esophageal atresia, renal anomalies, radial dysplasia (VATER) association (disorder)
Tree Number: T10.1.61
database_cross_reference: CHV:0000021179
database_cross_reference: DO:DOID:14679
database_cross_reference: ICD10CM:Q87.2
database_cross_reference: MDR:10053665
database_cross_reference: MEDCIN:312431
database_cross_reference: MSH:C536534
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:PKy96
database_cross_reference: SNM:D-5322
database_cross_reference: SNMI:D4-01401
database_cross_reference: SNOMEDCT_US:205830006
database_cross_reference: SNOMEDCT_US:27742002

Silver-Russell syndrome
type: Class
subclass of: chromosomal disease
PMOID: PMO:00028756
Subclass_of: chromosomal disease
Synonym: Dwarfism, Silver Russell
Synonym: Dwarfism, Silver-Russell
Synonym: RSS
Synonym: RUSSELL-SILVER SYNDROME
Synonym: Russell Silver Syndrome
Synonym: Russell dwarf
Synonym: Russell nanism
Synonym: Russell syndrome
Synonym: Russell's syndrome
Synonym: Russell-Silver Dwarfism
Tree Number: T10.5.9.1
database_cross_reference: CHV:0000018171
database_cross_reference: DO:DOID:14681
database_cross_reference: ICD10CM:Q87.1
database_cross_reference: JABL:593
database_cross_reference: MDR:10062282
database_cross_reference: MEDCIN:218971
database_cross_reference: MSH:D056730
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85068
database_cross_reference: NCI_NICHD:C85068
database_cross_reference: NDFRT:N0000181061
database_cross_reference: OMIM:180860
database_cross_reference: RCD:PKy62
database_cross_reference: SNM:D-2054
database_cross_reference: SNM:D-5025
database_cross_reference: SNMI:D4-00202
database_cross_reference: SNOMEDCT_US:15069006

Smith-Lemli-Opitz syndrome
type: Class
subclass of: lipid metabolism disorder
PMOID: PMO:00029257
Subclass_of: lipid metabolism disorder
Synonym: 7-Dehydrocholest reductase def
Synonym: 7-Dehydrocholesterol reductase deficiency
Synonym: Hyperotosis Corticalis Generalisata Familiaris
Synonym: LETHAL ACRODYSGENITAL SYNDROME
Synonym: POLYDACTYLY, SEX REVERSAL, RENAL HYPOPLASIA, AND UNILOBAR LUNG
Synonym: Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung
Synonym: RSH SLO Syndrome
Synonym: RSH SYNDROME
Synonym: RSH Syndrome
Synonym: RSH Syndromes
Tree Number: T10.6.2.18.4
database_cross_reference: CHV:0000018172
database_cross_reference: CSP:5002-0023
database_cross_reference: DO:DOID:14692
database_cross_reference: ICD10CM:E78.72
database_cross_reference: JABL:599
database_cross_reference: MDR:10078573
database_cross_reference: MEDCIN:36130
database_cross_reference: MSH:D019082
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85071
database_cross_reference: NCI_NICHD:C85071
database_cross_reference: NDFRT:N0000003894
database_cross_reference: OMIM:270400
database_cross_reference: OMIM:602858
database_cross_reference: RCD:PKy63
database_cross_reference: SNM:D-5047
database_cross_reference: SNMI:D4-00306
database_cross_reference: SNOMEDCT_US:43929004

thrombocytopenia-absent radius syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028782
Subclass_of: chromosomal deletion syndrome
Synonym: Absent radii and thrombocytopenia
Synonym: CHROMOSOME 1q21.1 DELETION SYNDROME, 200-KB
Synonym: Chromosome 1q21.1 Deletion Syndrome, 200-Kb
Synonym: Radial Aplasia-Amegakaryocytic Thrombocytopenia
Synonym: Radial Aplasia-Thrombocytopenia Syndrome
Synonym: Radial aplasia-thrombocytopenia syndrome
Synonym: Radial aplasia-thrombocytopenia syndrome (disorder)
Synonym: TAR
Synonym: TAR - Thrombocy abse rad synd
Synonym: TAR - Thrombocytopenia with absent radius syndrome
Tree Number: T10.5.9.8.5
database_cross_reference: CCPSS:0059219
database_cross_reference: CHV:0000018180
database_cross_reference: DO:DOID:14699
database_cross_reference: ICD10CM:Q87.2
database_cross_reference: MDR:10071719
database_cross_reference: MDR:10071720
database_cross_reference: MEDCIN:277685
database_cross_reference: MSH:C536940
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:287.33
database_cross_reference: NCI:C99038
database_cross_reference: NCI_NICHD:C99038
database_cross_reference: OMIM:274000
database_cross_reference: OMIM:605313
database_cross_reference: PDQ:CDR0000285979
database_cross_reference: RCD:D3132
database_cross_reference: SNM:D-5176
database_cross_reference: SNM:D-5366
database_cross_reference: SNMI:D4-00908
database_cross_reference: SNOMEDCT_US:85589009

FG syndrome
type: Class
subclass of: X-linked disease
definition: An X-linked disease characterized by retardation, hyperactivity, hypotonia, broad thumbs, big first toes and a characteristic facial appearance including macrocephaly and has an X-linked recessive inheritance pattern.
PMOID: PMO:00028728
Subclass_of: X-linked disease
Synonym: FG SYNDROME
Synonym: FG SYNDROME 1
Synonym: FG syndrome (disorder)
Synonym: FGS
Synonym: FGS1
Synonym: KELLER SYNDROME
Synonym: Keller syndrome
Synonym: MENTAL RETARDATION, LARGE HEAD, IMPERFORATE ANUS, CONGENITAL HYPOTONIA, AND PARTIAL AGENESIS OF CORPUS CALLOSUM
Synonym: Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, and Partial Agenesis of the Corpus Callosum
Synonym: OKS
Tree Number: T10.5.3.4.8
database_cross_reference: CHV:0000021188
database_cross_reference: DO:DOID:14711
database_cross_reference: JABL:500
database_cross_reference: MSH:C537923
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:300188
database_cross_reference: OMIM:305450
database_cross_reference: SNMI:D4-00814
database_cross_reference: SNOMEDCT_US:49984004

Weaver syndrome
type: Class
subclass of: physical disorder
PMOID: PMO:00028259
Subclass_of: physical disorder
Synonym: WEAVER-LIKE SYNDROME
Synonym: Weaver-Like Syndrome
Synonym: Weaver-Williams syndrome
Tree Number: T10.4.5
database_cross_reference: DO:DOID:14731
database_cross_reference: MSH:C562443
database_cross_reference: OMIM:277590

craniofrontonasal syndrome
type: Class
subclass of: X-linked disease
PMOID: PMO:00028726
Subclass_of: X-linked disease
Synonym: CFND
Synonym: CFNS
Synonym: CRANIOFRONTONASAL DYSOSTOSIS
Synonym: CRANIOFRONTONASAL DYSPLASIA
Synonym: CRANIOFRONTONASAL SYNDROME
Synonym: Craniofrontonasal dysostosis
Synonym: Craniofrontonasal dysplasia
Synonym: Craniofrontonasal dysplasia (disorder)
Synonym: Craniofrontonasal syndrome
Synonym: craniofrontonasal dysostosis
Tree Number: T10.5.3.4.6
database_cross_reference: CHV:0000021187
database_cross_reference: DO:DOID:14737
database_cross_reference: JABL:252
database_cross_reference: MSH:C536456
database_cross_reference: OMIM:300035
database_cross_reference: OMIM:304110
database_cross_reference: SNOMEDCT_US:715421009

lymphangioma
type: Class
subclass of: cell type benign neoplasm
PMOID: PMO:00027371
Subclass_of: cell type benign neoplasm
Synonym: Benign lymphangioma
Synonym: Benign lymphangioma (morphologic abnormality)
Synonym: Congenital lymphangioma
Synonym: Congenital lymphangioma (disorder)
Synonym: LYMPHANGIOMA
Synonym: LYMPHANGIOMA, BENIGN
Synonym: Lymphangioma
Synonym: Lymphangioma (disorder)
Synonym: Lymphangioma NOS
Synonym: Lymphangioma [Disease/Finding]
Tree Number: T10.2.3.1.5
database_cross_reference: CCPSS:1006008
database_cross_reference: CHV:0000007598
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2004-0139
database_cross_reference: DO:DOID:1475
database_cross_reference: HPO:HP:0100764
database_cross_reference: ICD10:D18.1
database_cross_reference: ICD10AM:D18.1
database_cross_reference: ICD10AM:M9170/0
database_cross_reference: ICD10CM:D18.1
database_cross_reference: ICD9CM:228.1
database_cross_reference: ICPC2P:K72007
database_cross_reference: ICPC2P:K99046
database_cross_reference: MDR:10025219
database_cross_reference: MDR:10025220
database_cross_reference: MEDCIN:30773
database_cross_reference: MSH:D008202
database_cross_reference: MTHICD9:228.1
database_cross_reference: NCI:C8965
database_cross_reference: NCI_CDISC:C8965
database_cross_reference: NCI_NICHD:C8965
database_cross_reference: NDFRT:N0000001894
database_cross_reference: OMIM:MTHU015908
database_cross_reference: RCD:BBU0.
database_cross_reference: RCD:X77p7
database_cross_reference: RCD:X78WK
database_cross_reference: RCD:Xa9AT
database_cross_reference: RCDSY:BBU0.
database_cross_reference: SNM:M-9170/0
database_cross_reference: SNMI:D3-F0700
database_cross_reference: SNMI:M-91700
database_cross_reference: SNOMEDCT_US:154625006
database_cross_reference: SNOMEDCT_US:189200000
database_cross_reference: SNOMEDCT_US:189875000
database_cross_reference: SNOMEDCT_US:253057002
database_cross_reference: SNOMEDCT_US:254836000
database_cross_reference: SNOMEDCT_US:269646001
database_cross_reference: SNOMEDCT_US:400178008
database_cross_reference: SNOMEDCT_US:69044001
database_cross_reference: SNOMEDCT_US:93168006

argininosuccinic aciduria
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves the accumulation of argininosuccinic acid (ASA) in the blood and urine.
PMOID: PMO:00029221
Subclass_of: amino acid metabolic disorder
Synonym: ACIDURIA, ARGININOSUCCINIC
Synonym: ARGININOSUCCINASE DEFICIENCY
Synonym: ARGININOSUCCINATE LYASE DEFICIENCY
Synonym: ARGININOSUCCINIC ACID LYASE DEFICIENCY
Synonym: ARGININOSUCCINIC ACIDURIA
Synonym: ASA Deficiencies
Synonym: ASA Deficiency
Synonym: ASAL deficiency
Synonym: ASL DEFICIENCY
Synonym: ASL Deficiencies
Tree Number: T10.6.2.15.23
database_cross_reference: CHV:0000026325
database_cross_reference: CSP:1849-9435
database_cross_reference: DO:DOID:14755
database_cross_reference: DXP:U000025
database_cross_reference: LNC:LA21162-5
database_cross_reference: MDR:10058299
database_cross_reference: MEDCIN:36131
database_cross_reference: MSH:D056807
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:270.6
database_cross_reference: NCI:C84569
database_cross_reference: NCI_NICHD:C84569
database_cross_reference: NDFRT:N0000181103
database_cross_reference: OMIM:207900
database_cross_reference: OMIM:608310
database_cross_reference: OMIM:MTHU014418
database_cross_reference: RCD:C3062
database_cross_reference: SNM:D-1725
database_cross_reference: SNMI:D6-A5310
database_cross_reference: SNOMEDCT_US:124630007
database_cross_reference: SNOMEDCT_US:41013004

renal agenesis
type: Class
subclass of: kidney disease
PMOID: PMO:00033038
Subclass_of: kidney disease
Synonym: BRA - Bilateral renal agenesis
Synonym: Bilateral Renal Agenesis
Synonym: Bilateral congenital absence of kidneys
Synonym: Bilateral renal agenesis
Synonym: Bilateral renal agenesis (disorder)
Synonym: Congenital absence kidneys
Synonym: Congenital absence of kidneys
Synonym: Congenital absence of kidneys syndrome
Synonym: Hereditary renal agenesis
Synonym: Potter Syndrome
Tree Number: T10.8.7.9.14
database_cross_reference: CHV:0000018292
database_cross_reference: HPO:HP:0010958
database_cross_reference: ICD10:Q60.1
database_cross_reference: ICD10AM:Q60.1
database_cross_reference: ICD10CM:Q60.1
database_cross_reference: MSH:C536482
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:753.0
database_cross_reference: NCI:C101219
database_cross_reference: NCI_NICHD:C101219
database_cross_reference: RCD:PD000
database_cross_reference: SNM:D-6531
database_cross_reference: SNMI:D4-01551
database_cross_reference: SNOMEDCT_US:204943000
database_cross_reference: SNOMEDCT_US:41962002

KBG syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.
PMOID: PMO:00025196
Subclass_of: syndrome
Synonym: KBG SYNDROME
Synonym: KBGS
Synonym: MACRODONTIA, MENTAL RETARDATION, CHARACTERISTIC FACIES, SHORT STATURE, AND SKELETAL ANOMALIES
Synonym: Short stature, characteristic facies, macrodontia, mental retardation, and skeletal anomalies
Synonym: Short stature-characteristic facies-mental retardation-macrodontia-skeletal anomalies syndrome
Synonym: Short stature-characteristic facies-mental retardation-macrodontia-skeletal anomalies syndrome (disorder)
Synonym: short stature-characteristic facies-mental retardation-macrodontia-skeletal anomalies syndrome
Tree Number: T10.1.74
database_cross_reference: DO:DOID:14780
database_cross_reference: JABL:382
database_cross_reference: MSH:C537015
database_cross_reference: OMIM:148050
database_cross_reference: OMIM:611192
database_cross_reference: SNOMEDCT_US:711156009

hypohidrotic ectodermal dysplasia
type: Class
subclass of: monogenic disease
definition: A monogenic disease that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth).
PMOID: PMO:00028737
Subclass_of: monogenic disease
Synonym: Anhidrotic Ectodermal Dysplasia 1
Synonym: Anhidrotic Ectodermal Dysplasia, X Linked
Synonym: Anhidrotic Ectodermal Dysplasia, X-Linked
Synonym: Anhidrotic ectodermal dysplasia syndrome, hereditary
Synonym: Anhydrotic Ectodermal Dysplasia, X Linked
Synonym: Anhydrotic Ectodermal Dysplasia, X-Linked
Synonym: CHRIST-SIEMENS-TOURAINE SYNDROME
Synonym: CST - Christ-Siemens-Touraine syndrome
Synonym: CST SYNDROME
Synonym: CST Syndrome
Tree Number: T10.5.3.6
database_cross_reference: CHV:0000017812
database_cross_reference: DO:DOID:14793
database_cross_reference: HPO:HP:0007607
database_cross_reference: MDR:10072592
database_cross_reference: MSH:D053358
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84562
database_cross_reference: NDFRT:N0000181060
database_cross_reference: OMIM:300451
database_cross_reference: OMIM:305100
database_cross_reference: RCD:X50H8
database_cross_reference: RCD:X50H9
database_cross_reference: SNM:D-3651
database_cross_reference: SNM:D-3654
database_cross_reference: SNMI:D4-01101
database_cross_reference: SNOMEDCT_US:239007005
database_cross_reference: SNOMEDCT_US:4826006
database_cross_reference: SNOMEDCT_US:7731005

Dubowitz syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.
PMOID: PMO:00025247
Subclass_of: syndrome
Synonym: DUBOWITZ SYNDROME
Synonym: Dubowitz Syndrome
Synonym: Dubowitz syndrome 1
Synonym: Dubowitz's syndrome
Synonym: Dubowitz's syndrome (diagnosis)
Synonym: Dubowitz's syndrome (disorder)
Synonym: Dwarfism-eczema-peculiar facies syndrome
Synonym: Harper's syndrome
Synonym: Seckel syndrome
Synonym: Virchow-Seckel dwarfism
Tree Number: T10.1.107
database_cross_reference: DO:DOID:0050569
database_cross_reference: DO:DOID:14796
database_cross_reference: ICD10CM:Q87.1
database_cross_reference: JABL:272
database_cross_reference: MDR:10059589
database_cross_reference: MEDCIN:360342
database_cross_reference: MSH:C535718
database_cross_reference: NCI:C125591
database_cross_reference: OMIM:223370
database_cross_reference: RCD:PKy66
database_cross_reference: SNM:D-5014
database_cross_reference: SNMI:D4-00204
database_cross_reference: SNOMEDCT_US:2593002

eye and adnexa disease
type: Class
subclass of: sensory system disease
definition: A sensory system disease that is located_in the eye or the adnexa of the eye.
PMOID: PMO:00030719
Subclass_of: sensory system disease
Synonym: Backgrnd retinopathy NOS
Synonym: Background retinopathy
Synonym: Background retinopathy (disorder)
Synonym: Background retinopathy unspec.
Synonym: Background retinopathy, NOS
Synonym: Background retinopathy, unspecified
Synonym: FEVR
Synonym: Retinopathy background
Synonym: Unspecified background retinopathy
Synonym: Unspecified background retinopathy (disorder)
Tree Number: T10.8.2.11.1
database_cross_reference: BI:BI00786
database_cross_reference: DO:DOID:0050535
database_cross_reference: DO:DOID:1492
database_cross_reference: ICD10CM:H35.00
database_cross_reference: ICD9CM:362.10
database_cross_reference: MDR:10003996
database_cross_reference: MDR:10038924
database_cross_reference: RCD:F4210
database_cross_reference: SNMI:DA-71720
database_cross_reference: SNOMEDCT_US:193355009
database_cross_reference: SNOMEDCT_US:31411005
database_cross_reference: SNOMEDCT_US:42873008

echinococcosis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.
PMOID: PMO:00029666
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Echinococcosis of liver
Synonym: echinococcal disease
Synonym: hepatic echinococcosis
Synonym: hydatid disease
Synonym: hydatidosis
Synonym: liver echinococcus
Synonym: pulmonary echinococcosis
Tree Number: T10.7.4.1.34
database_cross_reference: DO:DOID:1496

cholera
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock.
PMOID: PMO:00029502
Subclass_of: primary bacterial infectious disease
Synonym: (Cholera) or (Vibrio cholerae)
Synonym: (Cholera) or (Vibrio cholerae) (disorder)
Synonym: ASIATIC CHOLERA
Synonym: CHOLERA
Synonym: Cholera
Synonym: Cholera (disorder)
Synonym: Cholera - O1 group V cholerae
Synonym: Cholera - O1 group Vibrio cholerae
Synonym: Cholera - Vibrio cholerae
Synonym: Cholera - Vibrio cholerae (disorder)
Tree Number: T10.7.3.1.12
database_cross_reference: AOD:0000004856
database_cross_reference: CHV:0000002874
database_cross_reference: CSP:1248-3959
database_cross_reference: DO:DOID:1498
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000339
database_cross_reference: ICD10:A00
database_cross_reference: ICD10:A00.9
database_cross_reference: ICD10AM:A00
database_cross_reference: ICD10AM:A00.9
database_cross_reference: ICD10CM:A00
database_cross_reference: ICD10CM:A00.0
database_cross_reference: ICD10CM:A00.9
database_cross_reference: ICD9CM:001
database_cross_reference: ICD9CM:001.0
database_cross_reference: ICD9CM:001.9
database_cross_reference: ICPC2P:D70002
database_cross_reference: LCH_NW:sh85024645
database_cross_reference: MDR:10008631
database_cross_reference: MDR:10008632
database_cross_reference: MDR:10008634
database_cross_reference: MDR:10045658
database_cross_reference: MDR:10047397
database_cross_reference: MDR:10047398
database_cross_reference: MEDCIN:30913
database_cross_reference: MEDCIN:36176
database_cross_reference: MEDLINEPLUS:5709
database_cross_reference: MSH:D002771
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000761
database_cross_reference: RCD:A000.
database_cross_reference: RCD:A00z.
database_cross_reference: RCD:Ayu00
database_cross_reference: RCD:XE0Qc
database_cross_reference: RCD:Xa97W
database_cross_reference: RCDSY:Ayu00
database_cross_reference: SNM:D-0118
database_cross_reference: SNMI:DE-11600
database_cross_reference: SNMI:DE-11601
database_cross_reference: SNOMEDCT_US:154269008
database_cross_reference: SNOMEDCT_US:186087007
database_cross_reference: SNOMEDCT_US:186088002
database_cross_reference: SNOMEDCT_US:186089005
database_cross_reference: SNOMEDCT_US:187267007
database_cross_reference: SNOMEDCT_US:61972007
database_cross_reference: SNOMEDCT_US:63650001

reproductive system disease
type: Class
subclass of: disease of anatomical entity
PMOID: PMO:00029732
Subclass_of: disease of anatomical entity
Synonym: Disorder of Reproductive System
Synonym: Disorder of reproductive system
Synonym: Disorder of reproductive system (disorder)
Synonym: Genital Disorders
Synonym: Reproductive System Disease
Synonym: Reproductive System Disorder
Synonym: Reproductive tract disorder
Synonym: Reproductive tract disorder NOS
Synonym: disorder of reproductive system
Synonym: disorders reproductive system
Tree Number: T10.8.1
database_cross_reference: AOD:0000005856
database_cross_reference: AOD:0000005857
database_cross_reference: CHV:0000018381
database_cross_reference: CHV:0000043070
database_cross_reference: CSP:2587-5807
database_cross_reference: MDR:10038610
database_cross_reference: MDR:10061483
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4875
database_cross_reference: NCI_NICHD:C4875
database_cross_reference: PSY:20880
database_cross_reference: SNOMEDCT_US:362968007

disease of mental health
type: Class
subclass of: Disease
definition: A disorder that is a psychological or behavioral pattern associated with distress or disability that occurs in an individual and is not a part of normal development or culture.
PMOID: PMO:00027881
Subclass_of: Disease
Synonym: CHAPTER 9 MENTAL DISORDERS
Synonym: Disorder, Mental
Synonym: Disorder;psychological
Synonym: Disorders, Mental
Synonym: Emotional or mental disease or syndrome
Synonym: MENTAL DIS
Synonym: MENTAL DISORDERS
Synonym: MENTAL ILLNESS
Synonym: Mental Disorder
Synonym: Mental Disorders
Tree Number: T10.3
database_cross_reference: AOD:0000004129
database_cross_reference: AOD:0000006436
database_cross_reference: AOD:0000022732
database_cross_reference: AOD:0000023661
database_cross_reference: AOD:0000023662
database_cross_reference: AOD:0000023663
database_cross_reference: AOD:0000023664
database_cross_reference: CCPSS:0015917
database_cross_reference: CCPSS:0061455
database_cross_reference: CHV:0000001755
database_cross_reference: CHV:0000043034
database_cross_reference: CSP:2483-6609
database_cross_reference: CST:NERPSYCHNOS
database_cross_reference: DO:DOID:0050329
database_cross_reference: DO:DOID:150
database_cross_reference: DSM-5:300.9
database_cross_reference: DSM-5:F99
database_cross_reference: ICD10:F99
database_cross_reference: ICD10:F99-F99.9
database_cross_reference: ICD10AM:F99
database_cross_reference: ICD10AM:F99-F99.9
database_cross_reference: ICD10CM:F99
database_cross_reference: ICD10CM:F99-F99
database_cross_reference: ICPC2P:P79004
database_cross_reference: ICPC2P:P99003
database_cross_reference: ICPC2P:P99008
database_cross_reference: LCH_NW:sh85083643
database_cross_reference: LNC:LA10535-5
database_cross_reference: MDR:10027355
database_cross_reference: MDR:10037174
database_cross_reference: MDR:10037175
database_cross_reference: MDR:10050222
database_cross_reference: MDR:10061284
database_cross_reference: MEDCIN:32637
database_cross_reference: MEDLINEPLUS:5676
database_cross_reference: MSH:D001523
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2893
database_cross_reference: NCI_NICHD:C2893
database_cross_reference: NDFRT:N0000000538
database_cross_reference: OMIM:MTHU012421
database_cross_reference: PSY:30740
database_cross_reference: PSY:30850
database_cross_reference: PSY:41380
database_cross_reference: RCD:E....
database_cross_reference: RCD:Euz..
database_cross_reference: RCD:Ez...
database_cross_reference: RCDSY:Euz..
database_cross_reference: SNM:D-9000
database_cross_reference: SNM:F-90010
database_cross_reference: SNM:F-90020
database_cross_reference: SNMI:D9-00000
database_cross_reference: SNOMEDCT_US:154843007
database_cross_reference: SNOMEDCT_US:154971002
database_cross_reference: SNOMEDCT_US:154972009
database_cross_reference: SNOMEDCT_US:154980002
database_cross_reference: SNOMEDCT_US:192637001
database_cross_reference: SNOMEDCT_US:192639003
database_cross_reference: SNOMEDCT_US:74732009

avoidant personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.
PMOID: PMO:00027904
Subclass_of: personality disorder
Synonym: AVOIDANT PERSONALITY DIS
Synonym: Avoidant Personality Disorder
Synonym: Avoidant Personality Disorders
Synonym: Avoidant personality
Synonym: Avoidant personality dis
Synonym: Avoidant personality disorder
Synonym: Avoidant personality disorder (disorder)
Synonym: Personality Disorder, Avoidant
Synonym: Personality Disorders, Avoidant
Synonym: anxious personality disorder
Tree Number: T10.3.2.6
database_cross_reference: AOD:0000006688
database_cross_reference: CHV:0000001625
database_cross_reference: DO:DOID:1509
database_cross_reference: DSM-5:301.82
database_cross_reference: DSM-5:F60.6
database_cross_reference: ICD10CM:F60.6
database_cross_reference: ICD9CM:301.82
database_cross_reference: MDR:10003864
database_cross_reference: MDR:10003865
database_cross_reference: MEDCIN:32854
database_cross_reference: MSH:D010554
database_cross_reference: NCI:C92636
database_cross_reference: OMIM:MTHU000963
database_cross_reference: PSY:05205
database_cross_reference: RCD:E21y1
database_cross_reference: SNM:F-935Y0
database_cross_reference: SNMI:D9-63100
database_cross_reference: SNOMEDCT_US:191771004
database_cross_reference: SNOMEDCT_US:37746008

personality disorder
type: Class
subclass of: disease of mental health
PMOID: PMO:00027898
Subclass_of: disease of mental health
Synonym: -- Personality Disorder
Synonym: Character Disorders
Synonym: Character disorder NOS
Synonym: Character neurosis NOS
Synonym: DISORDER PERSONALITY
Synonym: Disorder personality
Synonym: Disorder;personality
Synonym: Disturbance in personality
Synonym: Neurotic personality disorder
Synonym: PERSONALITY DIS
Tree Number: T10.3.2
database_cross_reference: AOD:0000006629
database_cross_reference: AOD:0000006630
database_cross_reference: AOD:0000006637
database_cross_reference: AOD:0000023976
database_cross_reference: BI:BI00687
database_cross_reference: CCPSS:0045101
database_cross_reference: CHV:0000009544
database_cross_reference: COSTAR:580
database_cross_reference: CSP:2483-7148
database_cross_reference: CST:PERSON DIS
database_cross_reference: DSM-5:301.9
database_cross_reference: DSM-5:F60.9
database_cross_reference: DXP:U003113
database_cross_reference: HPO:HP:0012075
database_cross_reference: ICD10:F60.9
database_cross_reference: ICD10AM:F60.9
database_cross_reference: ICD10CM:F60.9
database_cross_reference: ICD9CM:301
database_cross_reference: ICD9CM:301.9
database_cross_reference: ICPC2EENG:P80
database_cross_reference: ICPC2P:P80002
database_cross_reference: LCH_NW:sh85100115
database_cross_reference: LNC:LA10579-3
database_cross_reference: MDR:10013256
database_cross_reference: MDR:10034721
database_cross_reference: MDR:10034722
database_cross_reference: MDR:10034725
database_cross_reference: MDR:10046097
database_cross_reference: MEDCIN:32858
database_cross_reference: MEDLINEPLUS:4117
database_cross_reference: MSH:D010554
database_cross_reference: MTHICD9:301.9
database_cross_reference: NCI:C34922
database_cross_reference: NDFRT:N0000002381
database_cross_reference: OMIM:MTHU037509
database_cross_reference: PSY:08490
database_cross_reference: PSY:37760
database_cross_reference: RCD:Eu60z
database_cross_reference: RCD:XE1YM
database_cross_reference: RCD:XE2b6
database_cross_reference: RCDSY:Eu60z
database_cross_reference: SNM:F-93510
database_cross_reference: SNMI:D9-60000
database_cross_reference: SNOMEDCT_US:154895004
database_cross_reference: SNOMEDCT_US:191749009
database_cross_reference: SNOMEDCT_US:191777000
database_cross_reference: SNOMEDCT_US:192494002
database_cross_reference: SNOMEDCT_US:268636006
database_cross_reference: SNOMEDCT_US:33449004

cecal disease
type: Class
subclass of: intestinal disease
definition: An intestinal disease located_in the cecum.
PMOID: PMO:00033624
Subclass_of: intestinal disease
Synonym: CECAL DIS
Synonym: Cecal Disease
Synonym: Cecal Diseases
Synonym: Cecal Diseases [Disease/Finding]
Synonym: Disease of caecum
Synonym: Disease of cecum
Synonym: Disease of cecum (disorder)
Synonym: Disease, Cecal
Synonym: Diseases, Cecal
Synonym: Disorder of caecum
Tree Number: T10.8.11.8.26
database_cross_reference: DO:DOID:1518
database_cross_reference: MSH:D002429
database_cross_reference: NDFRT:N0000000702
database_cross_reference: SNOMEDCT_US:128525008

panniculitis
type: Class
subclass of: skin disease
PMOID: PMO:00032408
Subclass_of: skin disease
Synonym: Inflammation of adipose tissue
Synonym: Inflammation of fat tissue
Synonym: PANNICULITIS
Synonym: Panniculitides
Synonym: Panniculitis
Synonym: Panniculitis (disorder)
Synonym: Panniculitis NOS
Synonym: Panniculitis NOS (disorder)
Synonym: Panniculitis [Disease/Finding]
Synonym: Panniculitis of unspecified site
Tree Number: T10.8.12.2.9
database_cross_reference: AOD:0000005146
database_cross_reference: CCPSS:0039159
database_cross_reference: CHV:0000009236
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:CELLULITIS
database_cross_reference: DO:DOID:1526
database_cross_reference: HPO:HP:0012490
database_cross_reference: ICD10:M79.3
database_cross_reference: ICD10AM:M79.3
database_cross_reference: ICD10AM:M79.39
database_cross_reference: ICD10CM:M79.3
database_cross_reference: ICD9CM:729.3
database_cross_reference: ICD9CM:729.30
database_cross_reference: ICPC2P:L18022
database_cross_reference: ICPC2P:L99083
database_cross_reference: MDR:10033674
database_cross_reference: MDR:10033675
database_cross_reference: MDR:10033680
database_cross_reference: MDR:10033681
database_cross_reference: MEDCIN:211130
database_cross_reference: MSH:D015434
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C112112
database_cross_reference: NCI_NICHD:C112112
database_cross_reference: NDFRT:N0000003238
database_cross_reference: OMIM:MTHU032395
database_cross_reference: RCD:N243.
database_cross_reference: RCD:N243z
database_cross_reference: RCD:X707z
database_cross_reference: RCD:XE1Fo
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D0-00580
database_cross_reference: SNOMEDCT_US:156779007
database_cross_reference: SNOMEDCT_US:203119008
database_cross_reference: SNOMEDCT_US:203120002
database_cross_reference: SNOMEDCT_US:203122005
database_cross_reference: SNOMEDCT_US:22125009
database_cross_reference: SNOMEDCT_US:268012006
database_cross_reference: SNOMEDCT_US:268122002

penile disease
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029736
Subclass_of: male reproductive system disease
Synonym: 7-57 DISEASES OF THE PENIS
Synonym: DISEASES OF THE PENIS
Synonym: DISORDER PENIS
Synonym: Disease of penis
Synonym: Disease of penis (disorder)
Synonym: Disease of penis, NOS
Synonym: Disease, Penile
Synonym: Disease, Penis
Synonym: Diseases, Penile
Synonym: Diseases, Penis
Tree Number: T10.8.1.3.1
database_cross_reference: CHV:0000009425
database_cross_reference: CSP:2587-6561
database_cross_reference: CST:PENIS DIS
database_cross_reference: CST:UG/MG/PEN
database_cross_reference: ICD10:N48.9
database_cross_reference: ICD10AM:N48.9
database_cross_reference: ICD10CM:N48.9
database_cross_reference: ICD9CM:607
database_cross_reference: ICD9CM:607.9
database_cross_reference: LCH_NW:sh85099484
database_cross_reference: MDR:10013252
database_cross_reference: MDR:10013345
database_cross_reference: MDR:10034303
database_cross_reference: MDR:10034336
database_cross_reference: MDR:10045820
database_cross_reference: MEDCIN:95377
database_cross_reference: MEDLINEPLUS:1360
database_cross_reference: MSH:D010409
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26846
database_cross_reference: NDFRT:N0000002348
database_cross_reference: RCD:K27..
database_cross_reference: RCD:K27z.
database_cross_reference: SNMI:D7-57000
database_cross_reference: SNOMEDCT_US:155927008
database_cross_reference: SNOMEDCT_US:155932009
database_cross_reference: SNOMEDCT_US:198041005
database_cross_reference: SNOMEDCT_US:266639006
database_cross_reference: SNOMEDCT_US:33958003

pleural disease
type: Class
subclass of: lower respiratory tract disease
definition: A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.
PMOID: PMO:00032605
Subclass_of: lower respiratory tract disease
Synonym: 2-80 DISEASES OF THE PLEURA
Synonym: DISEASES OF THE PLEURA
Synonym: Disease of pleura
Synonym: Disease of pleura (disorder)
Synonym: Disease of pleura, NOS
Synonym: Disease, Pleural
Synonym: Diseases, Pleural
Synonym: Disorder of pleura
Synonym: Disorder of pleura (disorder)
Synonym: PLEURAL
Tree Number: T10.8.5.4.3
database_cross_reference: AOD:0000005468
database_cross_reference: CHV:0000009850
database_cross_reference: CST:PLEURAL DIS
database_cross_reference: CST:PULMPLEURAL
database_cross_reference: DO:DOID:1532
database_cross_reference: LCH_NW:sh85103494
database_cross_reference: MDR:10035595
database_cross_reference: MDR:10035596
database_cross_reference: MDR:10035597
database_cross_reference: MEDCIN:91149
database_cross_reference: MEDLINEPLUS:4627
database_cross_reference: MSH:D010995
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26859
database_cross_reference: NDFRT:N0000002420
database_cross_reference: SNMI:D2-80000
database_cross_reference: SNOMEDCT_US:88075009

mixed cell type cancer
type: Class
subclass of: cell type cancer
definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from two germinal layers of tissue.
PMOID: PMO:00025311
Subclass_of: cell type cancer
Synonym: Malignant Mixed Neoplasm
Synonym: Malignant Mixed Tumor
Synonym: Malignant Mixed Tumors
Synonym: Malignant mixed tumor
Synonym: Malignant mixed tumour
Synonym: Mixed Tumor, Malignant
Synonym: Mixed Tumor, Malignant [Disease/Finding]
Synonym: Mixed Tumors, Malignant
Synonym: Mixed tumor, malignant
Synonym: Mixed tumor, malignant (morphologic abnormality)
Tree Number: T10.2.1.1.4
database_cross_reference: DO:DOID:154
database_cross_reference: ICD10AM:M8940/3
database_cross_reference: ICD10AMAE:M8940/3
database_cross_reference: MEDCIN:271537
database_cross_reference: MSH:D018198
database_cross_reference: MTH:U002408
database_cross_reference: NCI:C3729
database_cross_reference: NCI_CDISC:C3729
database_cross_reference: NDFRT:N0000003672
database_cross_reference: RCD:BBL4.
database_cross_reference: RCD:XM1FO
database_cross_reference: RCDAE:BBL4.
database_cross_reference: RCDAE:XM1FO
database_cross_reference: RCDSY:BBL4.
database_cross_reference: SNM:M-8940/3
database_cross_reference: SNMI:M-89403
database_cross_reference: SNOMEDCT_US:189802003
database_cross_reference: SNOMEDCT_US:8145008

urticaria
type: Class
subclass of: skin disease
PMOID: PMO:00033907
Subclass_of: skin disease
Synonym: (Urticaria NOS) or (hives)
Synonym: (Urticaria NOS) or (hives) (disorder)
Synonym: HIVES
Synonym: Hive
Synonym: Hives
Synonym: Hives NOS
Synonym: RASH URTICARIAL
Synonym: Rash urticarial
Synonym: URTICARIA
Synonym: Unspecified urticaria
Tree Number: T10.8.12.2.30
database_cross_reference: AOD:0000005229
database_cross_reference: AOD:0000023305
database_cross_reference: BI:BI00597
database_cross_reference: BI:BI00620
database_cross_reference: CCPSS:1000786
database_cross_reference: CHV:0000012810
database_cross_reference: CHV:0000050500
database_cross_reference: COSTAR:767
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2716-7007
database_cross_reference: CST:URTICARIA
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U004268
database_cross_reference: HPO:HP:0001025
database_cross_reference: ICD10:L50
database_cross_reference: ICD10:L50.9
database_cross_reference: ICD10AM:L50
database_cross_reference: ICD10AM:L50.9
database_cross_reference: ICD10CM:L50
database_cross_reference: ICD10CM:L50.9
database_cross_reference: ICD9CM:708
database_cross_reference: ICD9CM:708.9
database_cross_reference: ICPC2EENG:S98
database_cross_reference: ICPC2P:S98001
database_cross_reference: ICPC2P:S98003
database_cross_reference: LCH:U004874
database_cross_reference: LCH_NW:sh85141474
database_cross_reference: LNC:LA20642-7
database_cross_reference: MDR:10020197
database_cross_reference: MDR:10037896
database_cross_reference: MDR:10046219
database_cross_reference: MDR:10046735
database_cross_reference: MDR:10046736
database_cross_reference: MDR:10046749
database_cross_reference: MDR:10046756
database_cross_reference: MDR:10046757
database_cross_reference: MDR:10046758
database_cross_reference: MDR:10046760
database_cross_reference: MDR:10046761
database_cross_reference: MEDCIN:33123
database_cross_reference: MEDLINEPLUS:289
database_cross_reference: MSH:D014581
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:708.9
database_cross_reference: NCI:C3432
database_cross_reference: NCI_CTCAE:E13746
database_cross_reference: NCI_FDA:2278
database_cross_reference: NCI_NCI-GLOSS:CDR0000641139
database_cross_reference: NCI_NCI-GLOSS:CDR0000641140
database_cross_reference: NCI_NICHD:C3432
database_cross_reference: NDFRT:N0000003088
database_cross_reference: OMIM:MTHU037793
database_cross_reference: OMIM:MTHU044964
database_cross_reference: RCD:M28..
database_cross_reference: RCD:X75uX
database_cross_reference: RCD:XE1BT
database_cross_reference: SNM:D-3540
database_cross_reference: SNM:U000008
database_cross_reference: SNMI:M-36320
database_cross_reference: SNOMEDCT_US:126485001
database_cross_reference: SNOMEDCT_US:156427005
database_cross_reference: SNOMEDCT_US:157756002
database_cross_reference: SNOMEDCT_US:201272008
database_cross_reference: SNOMEDCT_US:247472004
database_cross_reference: SNOMEDCT_US:267818006

hypersensitivity reaction type III disease
type: Class
subclass of: hypersensitivity reaction disease
PMOID: PMO:00032705
Subclass_of: hypersensitivity reaction disease
Synonym: Disease, Immune Complex
Synonym: Diseases, Immune Complex
Synonym: Hypersensitivities, Type III
Synonym: Hypersensitivity, Type III
Synonym: IMMUNE COMPLEX DIS
Synonym: Immune Complex Disease
Synonym: Immune Complex Diseases
Synonym: Immune Complex Diseases [Disease/Finding]
Synonym: Immune complex disease
Synonym: Immune complex diseases
Tree Number: T10.8.6.3.2
database_cross_reference: CHV:0000006575
database_cross_reference: CSP:1560-5864
database_cross_reference: DO:DOID:1557
database_cross_reference: LCH:U002374
database_cross_reference: LCH_NW:sh85064534
database_cross_reference: MSH:D007105
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001665
database_cross_reference: SNM:D-4630

angioedema
type: Class
subclass of: skin disease
definition: A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues.
PMOID: PMO:00033889
Subclass_of: skin disease
Synonym: ANGIO-EDEMA
Synonym: ANGIOEDEMA
Synonym: ANGIONEUROTIC EDEMA
Synonym: Angio-edema
Synonym: Angio-edema-urticaria
Synonym: Angio-oedema
Synonym: Angio-oedema-urticaria
Synonym: Angioedema
Synonym: Angioedema (disorder)
Synonym: Angioedema [Disease/Finding]
Tree Number: T10.8.12.2.22
database_cross_reference: BI:BI00587
database_cross_reference: CCPSS:1001287
database_cross_reference: CHV:0000001177
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-1576
database_cross_reference: CSP:2716-7007
database_cross_reference: CST:ANGIOEDEMA
database_cross_reference: DO:DOID:1558
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000116
database_cross_reference: HPO:HP:0100665
database_cross_reference: ICD10:T78.3
database_cross_reference: ICD10AM:T78.3
database_cross_reference: ICD10AMAE:T78.3
database_cross_reference: ICD10CM:T78.3
database_cross_reference: ICPC2P:A12002
database_cross_reference: ICPC2P:A92010
database_cross_reference: LCH:U000249
database_cross_reference: LCH_NW:sh85005030
database_cross_reference: MDR:10002394
database_cross_reference: MDR:10002395
database_cross_reference: MDR:10002424
database_cross_reference: MDR:10002425
database_cross_reference: MDR:10002426
database_cross_reference: MDR:10002471
database_cross_reference: MDR:10002473
database_cross_reference: MDR:10014212
database_cross_reference: MDR:10014254
database_cross_reference: MDR:10018257
database_cross_reference: MDR:10018259
database_cross_reference: MDR:10020198
database_cross_reference: MDR:10037734
database_cross_reference: MDR:10037735
database_cross_reference: MDR:10046744
database_cross_reference: MDR:10055912
database_cross_reference: MDR:10055936
database_cross_reference: MEDCIN:31834
database_cross_reference: MSH:D000799
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:995.1
database_cross_reference: NCI:C112175
database_cross_reference: NCI_NICHD:C112175
database_cross_reference: NDFRT:N0000000415
database_cross_reference: OMIM:MTHU010698
database_cross_reference: RCD:SN51.
database_cross_reference: RCDAE:SN51.
database_cross_reference: SNM:D-3541
database_cross_reference: SNM:D-3547
database_cross_reference: SNM:D-4651
database_cross_reference: SNMI:D0-20100
database_cross_reference: SNOMEDCT_US:157756002
database_cross_reference: SNOMEDCT_US:269433002
database_cross_reference: SNOMEDCT_US:400075008
database_cross_reference: SNOMEDCT_US:41291007
database_cross_reference: SNOMEDCT_US:82966003

cognitive disorder
type: Class
subclass of: disease of mental health
PMOID: PMO:00028164
Subclass_of: disease of mental health
Synonym: COGNITION DIS
Synonym: COGNITIVE DEFICIT
Synonym: Cognition Disorders
Synonym: Cognition Disorders [Disease/Finding]
Synonym: Cognition disorders
Synonym: Cognitive Deficits
Synonym: Cognitive Disorder
Synonym: Cognitive disorder
Synonym: Cognitive disorder (disorder)
Synonym: Cognitive disorder NOS
Tree Number: T10.3.12
database_cross_reference: AOD:0000006349
database_cross_reference: AOD:0000023668
database_cross_reference: AOD:0000023669
database_cross_reference: CCPSS:0032234
database_cross_reference: CHV:0000003134
database_cross_reference: CHV:0000043077
database_cross_reference: COSTAR:U000509
database_cross_reference: CSP:2483-6315
database_cross_reference: LCH:U001084
database_cross_reference: LCH_NW:sh85027745
database_cross_reference: MDR:10048598
database_cross_reference: MDR:10057668
database_cross_reference: MEDCIN:312247
database_cross_reference: MSH:D003072
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:294.9
database_cross_reference: NCI:C92196
database_cross_reference: NDFRT:N0000000803
database_cross_reference: PSY:10075
database_cross_reference: SNOMEDCT_US:443265004

chromoblastomycosis
type: Class
subclass of: subcutaneous mycosis
definition: A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.
PMOID: PMO:00029308
Subclass_of: subcutaneous mycosis
Synonym: CHROMOBLASTOMYCOSIS
Synonym: CHROMOMYCOSIS
Synonym: Chromoblastomycoses
Synonym: Chromoblastomycosis
Synonym: Chromoblastomycosis (disorder)
Synonym: Chromoblastomycosis [Disease/Finding]
Synonym: Chromomycoses
Synonym: Chromomycosis
Synonym: Chromomycosis (disorder)
Synonym: Chromomycosis (disorder) [Ambiguous]
Tree Number: T10.7.1.3.1
database_cross_reference: CHV:0000002937
database_cross_reference: CSP:1988-4704
database_cross_reference: DO:DOID:1562
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000354
database_cross_reference: ICD10:B43.9
database_cross_reference: ICD10AM:B43.9
database_cross_reference: ICD10CM:B43.9
database_cross_reference: ICD9CM:117.2
database_cross_reference: MDR:10008803
database_cross_reference: MEDCIN:97689
database_cross_reference: MSH:D002862
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:117.2
database_cross_reference: NDFRT:N0000000782
database_cross_reference: RCD:AB62.
database_cross_reference: RCD:AyuEJ
database_cross_reference: RCD:X502j
database_cross_reference: RCDSY:AyuEJ
database_cross_reference: SNM:D-0558
database_cross_reference: SNMI:D0-10163
database_cross_reference: SNMI:DE-42100
database_cross_reference: SNOMEDCT_US:187079000
database_cross_reference: SNOMEDCT_US:187082005
database_cross_reference: SNOMEDCT_US:187490000
database_cross_reference: SNOMEDCT_US:238441002
database_cross_reference: SNOMEDCT_US:7255004

dermatomycosis
type: Class
subclass of: cutaneous mycosis
definition: A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.
PMOID: PMO:00029291
Subclass_of: cutaneous mycosis
Synonym: Cutaneous fungal disease
Synonym: Cutaneous mycosis
Synonym: Cutaneous mycosis, NOS
Synonym: DERMATITIS FUNGAL
Synonym: DERMATITIS FUNGOID
Synonym: DERMATOMYCOSIS
Synonym: Dermal mycosis
Synonym: Dermal mycosis (disorder)
Synonym: Dermal mycosis, NOS
Synonym: Dermatitis fungal
Tree Number: T10.7.1.2.1
database_cross_reference: CCPSS:0023188
database_cross_reference: CCPSS:0056231
database_cross_reference: CCPSS:0058682
database_cross_reference: CHV:0000003799
database_cross_reference: COSTAR:227
database_cross_reference: CSP:1988-4704
database_cross_reference: CST:DERM FUNG
database_cross_reference: DO:DOID:0050134
database_cross_reference: DO:DOID:1563
database_cross_reference: ICD9CM:111
database_cross_reference: ICD9CM:111.9
database_cross_reference: ICPC2P:S74002
database_cross_reference: ICPC2P:S74005
database_cross_reference: ICPC2P:S74006
database_cross_reference: ICPC2P:S74012
database_cross_reference: LCH:U001358
database_cross_reference: LCH_NW:sh85037095
database_cross_reference: MDR:10012463
database_cross_reference: MDR:10012464
database_cross_reference: MDR:10012465
database_cross_reference: MDR:10012501
database_cross_reference: MDR:10012502
database_cross_reference: MDR:10017526
database_cross_reference: MDR:10017527
database_cross_reference: MDR:10017543
database_cross_reference: MDR:10040853
database_cross_reference: MDR:10050578
database_cross_reference: MEDCIN:90182
database_cross_reference: MEDCIN:97629
database_cross_reference: MSH:D003881
database_cross_reference: NDFRT:N0000000945
database_cross_reference: OMIM:MTHU044478
database_cross_reference: RCD:AB1z.
database_cross_reference: RCD:X70QJ
database_cross_reference: SNM:D-0575
database_cross_reference: SNMI:DE-40040
database_cross_reference: SNMI:DE-45000
database_cross_reference: SNOMEDCT_US:14560005
database_cross_reference: SNOMEDCT_US:186984003
database_cross_reference: SNOMEDCT_US:187004009
database_cross_reference: SNOMEDCT_US:47382004

fungal infectious disease
type: Class
subclass of: disease by infectious agent
definition: A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body.
PMOID: PMO:00029284
Subclass_of: disease by infectious agent
Synonym: Disease caused by fungus
Synonym: Disease caused by fungus, NOS
Synonym: Disease, Fungal
Synonym: Disease, Fungus
Synonym: Diseases Caused by Fungi
Synonym: Diseases, Fungal
Synonym: Diseases, Fungus
Synonym: E-400 MYCOSES: GENERAL TERMS
Synonym: FUNGAL INFECTION
Synonym: FUNGUS DIS
Tree Number: T10.7.1
database_cross_reference: AOD:0000004875
database_cross_reference: AOD:0000023180
database_cross_reference: CCPSS:1014434
database_cross_reference: CHV:0000008396
database_cross_reference: COSTAR:318
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1988-3768
database_cross_reference: CST:INFECT FUNG
database_cross_reference: CST:SKIN/DERM/FUNG
database_cross_reference: DO:DOID:1564
database_cross_reference: DXP:U001628
database_cross_reference: ICD10:B35-B49.9
database_cross_reference: ICD10:B49
database_cross_reference: ICD10AM:B35-B49.9
database_cross_reference: ICD10AM:B49
database_cross_reference: ICD10CM:B35-B49
database_cross_reference: ICD10CM:B49
database_cross_reference: ICD9CM:110-118.99
database_cross_reference: ICPC2P:A78015
database_cross_reference: ICPC2P:A78017
database_cross_reference: LCH:U003083
database_cross_reference: LCH:U006399
database_cross_reference: LCH_NW:sh85089198
database_cross_reference: MDR:10017528
database_cross_reference: MDR:10017533
database_cross_reference: MDR:10017534
database_cross_reference: MDR:10021814
database_cross_reference: MDR:10021815
database_cross_reference: MDR:10021841
database_cross_reference: MDR:10067330
database_cross_reference: MEDCIN:319990
database_cross_reference: MEDCIN:90187
database_cross_reference: MEDLINEPLUS:258
database_cross_reference: MSH:D009181
database_cross_reference: MTH:318
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3245
database_cross_reference: NCI_FDA:2419
database_cross_reference: NCI_NICHD:C3245
database_cross_reference: NDFRT:N0000002075
database_cross_reference: OMIM:MTHU024875
database_cross_reference: RCD:AB...
database_cross_reference: RCD:ABz..
database_cross_reference: RCD:AyuES
database_cross_reference: RCDSY:AyuES
database_cross_reference: SNM:D-0550
database_cross_reference: SNM:U000003
database_cross_reference: SNMI:DE-40000
database_cross_reference: SNOMEDCT_US:154393000
database_cross_reference: SNOMEDCT_US:154394006
database_cross_reference: SNOMEDCT_US:187110007
database_cross_reference: SNOMEDCT_US:187472001
database_cross_reference: SNOMEDCT_US:187498007
database_cross_reference: SNOMEDCT_US:266214005
database_cross_reference: SNOMEDCT_US:3218000

alcohol use disorder
type: Class
subclass of: substance abuse
definition: A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.
PMOID: PMO:00027915
Subclass_of: substance abuse
Synonym: AA - Alcohol abuse
Synonym: ACA
Synonym: ALCOHOL ABUSE
Synonym: Abuse, Alcohol
Synonym: Alcohol Abuse
Synonym: Alcohol abuse
Synonym: Alcohol abuse (disorder)
Synonym: Alcohol abuse, unspecified
Synonym: Alcohol abuse, unspecified drinking behavior
Synonym: Alcohol abuse, unspecified drinking behaviour
Tree Number: T10.3.3.2.3
database_cross_reference: AOD:0000000070
database_cross_reference: AOD:0000004282
database_cross_reference: AOD:0000022854
database_cross_reference: BI:BI00005
database_cross_reference: CCPSS:1017305
database_cross_reference: CHV:0000015764
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000278
database_cross_reference: CSP:0080-8925
database_cross_reference: DO:DOID:1574
database_cross_reference: DRUGBANK:DB00376
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:F10.1
database_cross_reference: ICD9CM:305.0
database_cross_reference: ICD9CM:305.00
database_cross_reference: LNC:LP36309-0
database_cross_reference: LNC:MTHU019366
database_cross_reference: MDR:10001584
database_cross_reference: MDR:10001589
database_cross_reference: MDR:10063501
database_cross_reference: MEDCIN:314331
database_cross_reference: MEDCIN:32399
database_cross_reference: MSH:D000437
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:305.00
database_cross_reference: NCI:C20701
database_cross_reference: PSY:01660
database_cross_reference: PSY:40540
database_cross_reference: RCD:Xa1yZ
database_cross_reference: RCD:XaA1V
database_cross_reference: SNMI:D9-30100
database_cross_reference: SNOMEDCT_US:15167005
database_cross_reference: SNOMEDCT_US:304606004

respiratory system disease
type: Class
subclass of: disease of anatomical entity
PMOID: PMO:00032454
Subclass_of: disease of anatomical entity
Synonym: 2-00 RESPIRATORY DISEASES: GENERAL TERMS
Synonym: CHAPTER 2 DISEASES OF THE RESPIRATORY SYSTEM
Synonym: DISEASES OF THE RESPIRATORY SYSTEM
Synonym: DISORDER RESPIRATORY SYSTEM
Synonym: Disease of respiratory system
Synonym: Disease of respiratory system (disorder)
Synonym: Disease of respiratory system, NOS
Synonym: Disease or syndrome of respiratory system
Synonym: Disease;respiratory
Synonym: Diseases and Syndromes of Respiratory System
Tree Number: T10.8.5
database_cross_reference: AOD:0000005437
database_cross_reference: CHV:0000010755
database_cross_reference: CSP:2596-0107
database_cross_reference: CST:RESPIRAT DIS
database_cross_reference: ICD10:J00-J99.9
database_cross_reference: ICD10:J98.9
database_cross_reference: ICD10AM:J00-J99.9
database_cross_reference: ICD10AM:J98.9
database_cross_reference: ICD10CM:J00-J99
database_cross_reference: ICD10CM:J98.9
database_cross_reference: ICD9CM:460-519.99
database_cross_reference: ICD9CM:519.9
database_cross_reference: ICD9CM:V12.60
database_cross_reference: ICPC2P:R99003
database_cross_reference: MDR:10013264
database_cross_reference: MDR:10038683
database_cross_reference: MDR:10038684
database_cross_reference: MDR:10038719
database_cross_reference: MDR:10038720
database_cross_reference: MDR:10045755
database_cross_reference: MDR:10048527
database_cross_reference: MEDCIN:32874
database_cross_reference: MEDLINEPLUS:484
database_cross_reference: MSH:D012120
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:519.9
database_cross_reference: NCI:C26871
database_cross_reference: NCI_NICHD:C26871
database_cross_reference: NDFRT:N0000002595
database_cross_reference: RCD:H....
database_cross_reference: RCD:H5z..
database_cross_reference: SNM:D-7500
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D2-00000
database_cross_reference: SNOMEDCT_US:155495001
database_cross_reference: SNOMEDCT_US:155615008
database_cross_reference: SNOMEDCT_US:155627006
database_cross_reference: SNOMEDCT_US:155628001
database_cross_reference: SNOMEDCT_US:196185004
database_cross_reference: SNOMEDCT_US:196261001
database_cross_reference: SNOMEDCT_US:266374002
database_cross_reference: SNOMEDCT_US:266411000
database_cross_reference: SNOMEDCT_US:50043002

rheumatic fever
type: Class
subclass of: bacterial infectious disease
PMOID: PMO:00029598
Subclass_of: bacterial infectious disease
Synonym: ACUTE RHEUMATIC FEVER
Synonym: ARF
Synonym: ARF - Acute rheumatic fever
Synonym: Active rheumatic fever
Synonym: Active rheumatic fever (disorder)
Synonym: Acute Articular Rheumatism
Synonym: Acute Articular Rheumatisms
Synonym: Acute Rheumatic Arthritides
Synonym: Acute Rheumatic Arthritis
Synonym: Acute Rheumatic Fever
Tree Number: T10.7.3.2
database_cross_reference: AOD:0000004874
database_cross_reference: CCPSS:1000397
database_cross_reference: CCPSS:1005985
database_cross_reference: CHV:0000010844
database_cross_reference: CHV:0000032094
database_cross_reference: COSTAR:652
database_cross_reference: CSP:0368-3578
database_cross_reference: DO:DOID:1586
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001680
database_cross_reference: ICD10:I00-I02.9
database_cross_reference: ICD10AM:I00-I02.9
database_cross_reference: ICD10CM:I00-I02
database_cross_reference: ICD9CM:390-392.99
database_cross_reference: ICPC2P:K71003
database_cross_reference: LCH:U004118
database_cross_reference: LCH_NW:sh85113639
database_cross_reference: LNC:LA16999-7
database_cross_reference: MDR:10001060
database_cross_reference: MDR:10039054
database_cross_reference: MDR:10072738
database_cross_reference: MDR:10075557
database_cross_reference: MEDCIN:31305
database_cross_reference: MEDLINEPLUS:421
database_cross_reference: MSH:D012213
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:390
database_cross_reference: NCI:C34984
database_cross_reference: NCI_NICHD:C34984
database_cross_reference: NDFRT:N0000002629
database_cross_reference: PSY:44550
database_cross_reference: RCD:G0...
database_cross_reference: RCD:G0z..
database_cross_reference: RCD:XM0rI
database_cross_reference: SNM:D-3840
database_cross_reference: SNM:D-3841
database_cross_reference: SNMI:D3-17100
database_cross_reference: SNMI:D3-17112
database_cross_reference: SNMI:D3-17114
database_cross_reference: SNOMEDCT_US:155264006
database_cross_reference: SNOMEDCT_US:155274009
database_cross_reference: SNOMEDCT_US:194718003
database_cross_reference: SNOMEDCT_US:195528001
database_cross_reference: SNOMEDCT_US:26424001
database_cross_reference: SNOMEDCT_US:266276003
database_cross_reference: SNOMEDCT_US:274095001
database_cross_reference: SNOMEDCT_US:58718002
database_cross_reference: SNOMEDCT_US:81077008

mental depression
type: Class
subclass of: mood disorder
PMOID: PMO:00028205
Subclass_of: mood disorder
Synonym: DEPRESSED STATE
Synonym: DEPRESSION
Synonym: DEPRESSION MENTAL
Synonym: DEPRESSION PSYCHIC
Synonym: Depressed state
Synonym: Depression
Synonym: Depression (Emotion)
Synonym: Depression (finding)
Synonym: Depression NOS
Synonym: Depression NOS (disorder)
Tree Number: T10.3.12.2.4
database_cross_reference: AOD:0000022482
database_cross_reference: AOD:0000023826
database_cross_reference: AOD:0000023835
database_cross_reference: BI:BI00003
database_cross_reference: CCPSS:1017889
database_cross_reference: CHV:0000003777
database_cross_reference: COSTAR:224
database_cross_reference: CSP:2483-2785
database_cross_reference: CST:DEPRESSION
database_cross_reference: CST:NERDEPRESS
database_cross_reference: DO:DOID:1596
database_cross_reference: DXP:U000951
database_cross_reference: ICD10CM:F32.9
database_cross_reference: ICD10CM:F33.9
database_cross_reference: ICPC2P:P76001
database_cross_reference: ICPC2P:P76004
database_cross_reference: LCH:U001350
database_cross_reference: LCH_NW:sh85037053
database_cross_reference: LNC:MTHU013514
database_cross_reference: MDR:10012377
database_cross_reference: MDR:10012378
database_cross_reference: MDR:10012386
database_cross_reference: MDR:10012387
database_cross_reference: MDR:10012392
database_cross_reference: MDR:10049709
database_cross_reference: MEDLINEPLUS:113
database_cross_reference: MSH:D003863
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U001856
database_cross_reference: MTHICD9:311
database_cross_reference: NCI:C2982
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CTCAE:E12909
database_cross_reference: NCI_FDA:2361
database_cross_reference: NCI_NCI-GLOSS:CDR0000430479
database_cross_reference: OMIM:MTHU000940
database_cross_reference: PSY:13650
database_cross_reference: RCD:X00SO
database_cross_reference: RCD:XE1Zb
database_cross_reference: RCD:XaB9J
database_cross_reference: RCDSY:XE1Zb
database_cross_reference: SNM:F-90820
database_cross_reference: SNMI:F-92300
database_cross_reference: SNOMEDCT_US:154963001
database_cross_reference: SNOMEDCT_US:192372006
database_cross_reference: SNOMEDCT_US:307537002
database_cross_reference: SNOMEDCT_US:41006004

integumentary system disease
type: Class
subclass of: disease of anatomical entity
definition: A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages.
PMOID: PMO:00033757
Subclass_of: disease of anatomical entity
Tree Number: T10.8.12
database_cross_reference: DO:DOID:16

keratosis
type: Class
subclass of: skin disease
definition: A skin disease characterized_by growth of keratin on the skin or mucous membranes.
PMOID: PMO:00033792
Subclass_of: skin disease
Synonym: KERATOSIS
Synonym: Keratoses
Synonym: Keratosis
Synonym: Keratosis (disorder)
Synonym: Keratosis [Disease/Finding]
Synonym: Keratosis, NOS
Synonym: keratoses
Tree Number: T10.8.12.2.6
database_cross_reference: CHV:0000007064
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2716-7025
database_cross_reference: CST:HYPERTROPHY SKIN
database_cross_reference: DO:DOID:161
database_cross_reference: ICPC2P:S21004
database_cross_reference: LCH:U002573
database_cross_reference: LCH_NW:sh85072040
database_cross_reference: MDR:10023368
database_cross_reference: MSH:D007642
database_cross_reference: MTH:435
database_cross_reference: MTH:671
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34747
database_cross_reference: NDFRT:N0000001741
database_cross_reference: RCD:X78Rg
database_cross_reference: SNM:M-72600
database_cross_reference: SNMI:M-72600
database_cross_reference: SNOMEDCT_US:254666005

cancer
type: Class
subclass of: disease of cellular proliferation
definition: A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
PMOID: PMO:00025251
Subclass_of: disease of cellular proliferation
Synonym: (Neoplasms) or (cancers)
Synonym: (Neoplasms) or (cancers) (disorder)
Synonym: CA
Synonym: CA - Cancer
Synonym: CANCER
Synonym: CANCER (NOS)
Synonym: Ca - unspecified site
Synonym: Ca - unspecified site NOS
Synonym: Ca - unspecified site NOS (disorder)
Synonym: Cancer
Tree Number: T10.2.1
database_cross_reference: AOD:0000004520
database_cross_reference: AOD:0000023014
database_cross_reference: AOD:0000023015
database_cross_reference: AOD:0000023016
database_cross_reference: BI:BI00731
database_cross_reference: CCPSS:1001968
database_cross_reference: CCPSS:1017904
database_cross_reference: CHV:0000002337
database_cross_reference: COSTAR:465
database_cross_reference: COSTAR:U000036
database_cross_reference: CSP:2000-0173
database_cross_reference: CST:CARCINOMA
database_cross_reference: CST:PATHMALIGN
database_cross_reference: CST:RETICMALIG
database_cross_reference: DO:DOID:162
database_cross_reference: DXP:U000537
database_cross_reference: HPO:HP:0002664
database_cross_reference: ICD10:C00-C97.9
database_cross_reference: ICD10:C80
database_cross_reference: ICD10AM:C00-C97.9
database_cross_reference: ICD10AM:C80
database_cross_reference: ICD10AM:M8000/3
database_cross_reference: ICD10CM:C80
database_cross_reference: ICD10CM:C80.1
database_cross_reference: ICD9CM:199
database_cross_reference: ICPC2EENG:A79
database_cross_reference: ICPC2P:A79001
database_cross_reference: LCH:U006339
database_cross_reference: LCH_NW:sh85019492
database_cross_reference: LNC:LA10524-9
database_cross_reference: LNC:LP100805-3
database_cross_reference: LNC:LP128794-7
database_cross_reference: LNC:LP20701-6
database_cross_reference: LNC:LP7106-0
database_cross_reference: LNC:MTHU010328
database_cross_reference: LNC:MTHU040703
database_cross_reference: LNC:MTHU051589
database_cross_reference: MDR:10007050
database_cross_reference: MDR:10007051
database_cross_reference: MDR:10025691
database_cross_reference: MDR:10026655
database_cross_reference: MDR:10028997
database_cross_reference: MDR:10049516
database_cross_reference: MDR:10073835
database_cross_reference: MEDCIN:31465
database_cross_reference: MEDCIN:99725
database_cross_reference: MEDLINEPLUS:1
database_cross_reference: MEDLINEPLUS:25
database_cross_reference: MSH:D009369
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:199.1
database_cross_reference: NCI:C9305
database_cross_reference: NCI:NHIS
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C9305
database_cross_reference: NCI_FDA:3262
database_cross_reference: NCI_NCI-GLOSS:CDR0000045333
database_cross_reference: NCI_NCI-GLOSS:CDR0000045771
database_cross_reference: NCI_NICHD:C9305
database_cross_reference: PDQ:CDR0000041060
database_cross_reference: PSY:07420
database_cross_reference: PSY:29280
database_cross_reference: RCD:B59..
database_cross_reference: RCD:B59z.

chronic interstitial cystitis
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032303
Subclass_of: connective tissue disease
Synonym: CYSTITIS, CHRONIC INTERSTITIAL
Synonym: Chr interstit cystitis
Synonym: Chronic Interstitial Cystitides
Synonym: Chronic Interstitial Cystitis
Synonym: Chronic interstit.cystitis NOS
Synonym: Chronic interstitial cystitis
Synonym: Chronic interstitial cystitis (disorder)
Synonym: Chronic interstitial cystitis (disorder) [Ambiguous]
Synonym: Chronic interstitial cystitis NOS
Synonym: Chronic interstitial cystitis NOS (disorder)
Tree Number: T10.8.4.1.18
database_cross_reference: CHV:0000042150
database_cross_reference: DO:DOID:1678
database_cross_reference: DXP:U000435
database_cross_reference: ICD10:N30.1
database_cross_reference: ICD10AM:N30.1
database_cross_reference: ICD10CM:N30.1
database_cross_reference: ICD9CM:595.1
database_cross_reference: MDR:10008927
database_cross_reference: MDR:10008928
database_cross_reference: MEDCIN:34183
database_cross_reference: MSH:D018856
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:K151.
database_cross_reference: RCD:K151z
database_cross_reference: SNMI:D7-21120
database_cross_reference: SNOMEDCT_US:197834003
database_cross_reference: SNOMEDCT_US:197838000
database_cross_reference: SNOMEDCT_US:44497007

cystitis
type: Class
subclass of: bladder disease
PMOID: PMO:00033094
Subclass_of: bladder disease
Synonym: Bladder infection
Synonym: Bladder infection (diagnosis)
Synonym: Bladder inflammation
Synonym: CYSTITIS
Synonym: CYSTITIS (NOS)
Synonym: Cystalgia
Synonym: Cystitides
Synonym: Cystitis
Synonym: Cystitis (NOS)
Synonym: Cystitis (disorder)
Tree Number: T10.8.7.11.7
database_cross_reference: BI:BI00430
database_cross_reference: CCPSS:1003248
database_cross_reference: CHV:0000003558
database_cross_reference: COSTAR:218
database_cross_reference: CST:CYSTITIS
database_cross_reference: DO:DOID:1679
database_cross_reference: DXP:U000922
database_cross_reference: HPO:HP:0100577
database_cross_reference: ICD10:N30
database_cross_reference: ICD10:N30.9
database_cross_reference: ICD10AM:N30
database_cross_reference: ICD10AM:N30.9
database_cross_reference: ICD10CM:N30
database_cross_reference: ICD10CM:N30.9
database_cross_reference: ICD9CM:595
database_cross_reference: ICD9CM:595.9
database_cross_reference: ICPC2P:U71007
database_cross_reference: LCH_NW:sh85014731
database_cross_reference: MDR:10011754
database_cross_reference: MDR:10011781
database_cross_reference: MDR:10011782
database_cross_reference: MDR:10011798
database_cross_reference: MDR:10011802
database_cross_reference: MDR:10063059
database_cross_reference: MEDCIN:30920
database_cross_reference: MEDCIN:363072
database_cross_reference: MEDLINEPLUS:1274
database_cross_reference: MSH:D003556
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26738
database_cross_reference: NDFRT:N0000000894
database_cross_reference: RCD:K15..
database_cross_reference: RCD:K15z.
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D7-21100
database_cross_reference: SNOMEDCT_US:155882000
database_cross_reference: SNOMEDCT_US:155885003
database_cross_reference: SNOMEDCT_US:197857009
database_cross_reference: SNOMEDCT_US:266629000
database_cross_reference: SNOMEDCT_US:38822007
database_cross_reference: SNOMEDCT_VET:38822007

congenital heart disease
type: Class
subclass of: heart disease
PMOID: PMO:00031796
Subclass_of: heart disease
Synonym: 4-31 CONGENITAL ANOMALIES OF THE HEART
Synonym: ABNORM HEART
Synonym: ANOMALY CARDIAC
Synonym: ANOMALY HEART
Synonym: Abnormal heart morphology
Synonym: Abnormalities, Heart
Synonym: Abnormality of cardiac morphology
Synonym: Abnormality of the heart
Synonym: Abnormality, Heart
Synonym: Anomaly cardiac
Tree Number: T10.8.3.2.8
database_cross_reference: AOD:0000005254
database_cross_reference: CCPSS:0043687
database_cross_reference: CHV:0000005874
database_cross_reference: COSTAR:U000203
database_cross_reference: CSP:0724-8315
database_cross_reference: CST:ANOMALY HEART
database_cross_reference: DO:DOID:1682
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000547
database_cross_reference: HPO:HP:0001627
database_cross_reference: HPO:HP:0002564
database_cross_reference: ICD10:Q24.9
database_cross_reference: ICD10AM:Q24.9
database_cross_reference: ICD10CM:Q24.9
database_cross_reference: ICD9CM:746.9
database_cross_reference: ICPC2P:K73004
database_cross_reference: LCH_NW:sh85059634
database_cross_reference: MDR:10002616
database_cross_reference: MDR:10002626
database_cross_reference: MDR:10019293
database_cross_reference: MDR:10025528
database_cross_reference: MDR:10045703
database_cross_reference: MEDCIN:33162
database_cross_reference: MEDLINEPLUS:198
database_cross_reference: MSH:D006330
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:746.9
database_cross_reference: NCI:C34666
database_cross_reference: NDFRT:N0000001431
database_cross_reference: OMIM:140500
database_cross_reference: OMIM:234750
database_cross_reference: OMIM:MTHU008662
database_cross_reference: OMIM:MTHU013668
database_cross_reference: OMIM:MTHU021246
database_cross_reference: OMIM:MTHU024793
database_cross_reference: OMIM:MTHU033032
database_cross_reference: OMIM:MTHU036327
database_cross_reference: RCD:P6zz.
database_cross_reference: SNMI:D4-31000
database_cross_reference: SNOMEDCT_US:13213009
database_cross_reference: SNOMEDCT_US:156911006
database_cross_reference: SNOMEDCT_US:156926008
database_cross_reference: SNOMEDCT_US:204405005
database_cross_reference: SNOMEDCT_US:204413006
database_cross_reference: SNOMEDCT_US:268315002
database_cross_reference: SNOMEDCT_US:268318000

ichthyosis
type: Class
subclass of: skin disease
definition: A skin disease characterized by drying and scaling of skin with the accumulation of thick scales and cracks that may be painful or bleed.
PMOID: PMO:00033884
Subclass_of: skin disease
Synonym: Fish scale disease
Synonym: Hypertrophic ichthyosis
Synonym: ICHTHYOSIS
Synonym: ICTHYOSIS
Synonym: Ichthyoses
Synonym: Ichthyosiform abnormality of the skin
Synonym: Ichthyosis
Synonym: Ichthyosis [Disease/Finding]
Synonym: Ichthyosis, NOS
Synonym: Ichthyotic skin
Tree Number: T10.8.12.2.18
database_cross_reference: CCPSS:1014432
database_cross_reference: CHV:0000006527
database_cross_reference: COSTAR:407
database_cross_reference: COSTAR:U000351
database_cross_reference: CST:ICHTHYOSIS
database_cross_reference: DO:DOID:1697
database_cross_reference: DXP:U002066
database_cross_reference: HPO:HP:0008064
database_cross_reference: LCH_NW:sh89003841
database_cross_reference: MDR:10021197
database_cross_reference: MDR:10021198
database_cross_reference: MDR:10040812
database_cross_reference: MEDCIN:33101
database_cross_reference: MSH:D007057
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84776
database_cross_reference: NCI_NICHD:C84776
database_cross_reference: NDFRT:N0000001659
database_cross_reference: OMIM:MTHU000702
database_cross_reference: OMIM:MTHU049570
database_cross_reference: SNM:M-74410
database_cross_reference: SNMI:D4-40110

musculoskeletal system disease
type: Class
subclass of: disease of anatomical entity
definition: A disease of anatomical entity that occurs in the muscular and/or skeletal system.
PMOID: PMO:00032008
Subclass_of: disease of anatomical entity
Synonym: Disease of musculoskeletal system
Synonym: Disease of musculoskeletal system (disorder)
Synonym: Disease of the musculoskeletal system, NOS
Synonym: Disease;musculoskeletal
Synonym: Disorder of Musculoskeletal System
Synonym: Disorder of musculoskel syst
Synonym: Disorder of musculoskeletal system
Synonym: Disorder of musculoskeletal system (disorder)
Synonym: Disorder of the musculoskeletal system, NOS
Synonym: MUSCULOSKELETAL DIS
Tree Number: T10.8.4
database_cross_reference: CCPSS:0057224
database_cross_reference: CHV:0000008364
database_cross_reference: CSP:4000-0257
database_cross_reference: DO:DOID:17
database_cross_reference: ICPC2P:L99086
database_cross_reference: LCH_NW:sh85088700
database_cross_reference: MDR:10028379
database_cross_reference: MDR:10048592
database_cross_reference: MEDCIN:338581
database_cross_reference: MSH:D009140
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C107377
database_cross_reference: NCI_NICHD:C107377
database_cross_reference: NDFRT:N0000002067
database_cross_reference: PSY:32630
database_cross_reference: PSY:47660
database_cross_reference: RCD:XE1DD
database_cross_reference: RCD:XM0v0
database_cross_reference: SNMI:D1-00000
database_cross_reference: SNOMEDCT_US:156881000
database_cross_reference: SNOMEDCT_US:268047003
database_cross_reference: SNOMEDCT_US:268142006
database_cross_reference: SNOMEDCT_US:274149006
database_cross_reference: SNOMEDCT_US:928000

endocrine gland cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.
PMOID: PMO:00025425
Subclass_of: organ system cancer
Synonym: ENDOCRINE GLAND NEOPL
Synonym: ENDOCRINE NEOPLASIA
Synonym: Endocrine Gland Neoplasm
Synonym: Endocrine Gland Neoplasms
Synonym: Endocrine Gland Neoplasms [Disease/Finding]
Synonym: Endocrine Neoplasm
Synonym: Endocrine Neoplasms
Synonym: Endocrine System Neoplasm
Synonym: Endocrine System Tumor
Synonym: Endocrine Tumor
Tree Number: T10.2.1.2.1
database_cross_reference: AOD:0000023101
database_cross_reference: AOD:0000023102
database_cross_reference: CCPSS:0035534
database_cross_reference: CHV:0000004449
database_cross_reference: CHV:0000047500
database_cross_reference: CSP:2009-5861
database_cross_reference: DO:DOID:170
database_cross_reference: HPO:HP:0100568
database_cross_reference: ICPC2P:T73005
database_cross_reference: LCH_NW:sh87001844
database_cross_reference: MDR:10014709
database_cross_reference: MDR:10061121
database_cross_reference: MEDCIN:90717
database_cross_reference: MSH:D004701
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3010
database_cross_reference: NDFRT:N0000001100
database_cross_reference: PSY:17340
database_cross_reference: RCD:X78cM
database_cross_reference: RCDAE:X78cM
database_cross_reference: SNOMEDCT_US:127015005
database_cross_reference: SNOMEDCT_US:387922007
database_cross_reference: SNOMEDCT_US:387927001

X-linked ichthyosis
type: Class
subclass of: X-linked disease
PMOID: PMO:00028724
Subclass_of: X-linked disease
Synonym: ICHTHYOSIS, X-LINKED
Synonym: Ichthyoses, Sex-Linked
Synonym: Ichthyoses, X-Linked
Synonym: Ichthyosis, Sex Linked
Synonym: Ichthyosis, Sex-Linked
Synonym: Ichthyosis, X Linked
Synonym: Ichthyosis, X-Linked
Synonym: Ichthyosis, X-Linked [Disease/Finding]
Synonym: Ichthyosis, X-linked
Synonym: Ichthyosis, sex-linked, recessive
Tree Number: T10.5.3.4.4
database_cross_reference: CHV:0000015193
database_cross_reference: DO:DOID:1700
database_cross_reference: ICD10:Q80.1
database_cross_reference: ICD10AM:Q80.1
database_cross_reference: ICD10CM:Q80.1
database_cross_reference: MDR:10048063
database_cross_reference: MEDCIN:331128
database_cross_reference: MEDCIN:359444
database_cross_reference: MSH:D016114
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84779
database_cross_reference: NDFRT:N0000003368
database_cross_reference: OMIM:300747
database_cross_reference: OMIM:308100
database_cross_reference: RCD:X78CB
database_cross_reference: SNM:D-3671
database_cross_reference: SNMI:D4-40112
database_cross_reference: SNMI:D6-80600
database_cross_reference: SNOMEDCT_US:205552006
database_cross_reference: SNOMEDCT_US:254160003
database_cross_reference: SNOMEDCT_US:402771003
database_cross_reference: SNOMEDCT_US:72523005

steroid inherited metabolic disorder
type: Class
subclass of: lipid metabolism disorder
definition: A lipid metabolism disorder that involves defects in steroid metabolism.
PMOID: PMO:00029268
Subclass_of: lipid metabolism disorder
Synonym: Congenital Errors of Steroid Metabolism
Synonym: Inborn Errors of Steroid Metabolism
Synonym: Steroid Metabolic Diseases, Inborn
Synonym: Steroid Metabolism, Inborn Errors
Synonym: Steroid Metabolism, Inborn Errors [Disease/Finding]
Tree Number: T10.6.2.18.8
database_cross_reference: DO:DOID:1701
database_cross_reference: MSH:D043202
database_cross_reference: NDFRT:N0000011088

duodenal ulcer
type: Class
subclass of: peptic ulcer disease
PMOID: PMO:00033436
Subclass_of: peptic ulcer disease
Synonym: Curling Ulcer
Synonym: Curling ulcers
Synonym: Curling's Ulcer
Synonym: Curling's ulcer
Synonym: Curling's ulcers
Synonym: Curling's ulcers (disorder)
Synonym: Curlings Ulcer
Synonym: Stress Ulcer
Synonym: ULCER, CURLINGS
Synonym: ULCER, GASTROINTESTINAL, FOLLOWING BURN
Tree Number: T10.8.11.1.6
database_cross_reference: CHV:0000003507
database_cross_reference: DO:DOID:1724
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001946
database_cross_reference: MDR:10011646
database_cross_reference: MSH:D004381
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:M-38060
database_cross_reference: SNMI:D5-32114
database_cross_reference: SNOMEDCT_US:39755000

peritoneum cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer that is located in the peritoneum.
PMOID: PMO:00026322
Subclass_of: organ system cancer
Synonym: Mal neo peritoneum NEC
Synonym: Malig neop spec part periton
Synonym: Malig neop spec perit part NOS
Synonym: Malignant neoplasm of specified parts of peritoneum
Synonym: Malignant neoplasm of specified parts of peritoneum (disorder)
Synonym: Malignant neoplasm of specified parts of peritoneum NOS
Synonym: Malignant neoplasm of specified parts of peritoneum NOS (disorder)
Synonym: Specified parts of peritoneum
Synonym: malignant neoplasm of specified parts of peritoneum
Synonym: malignant neoplasm of specified parts of peritoneum (diagnosis)
Tree Number: T10.2.1.2.6
database_cross_reference: DO:DOID:1725
database_cross_reference: ICD10:C48.1
database_cross_reference: ICD10AM:C48.1
database_cross_reference: ICD10CM:C48.1
database_cross_reference: ICD9CM:158.8
database_cross_reference: MDR:10026469
database_cross_reference: MEDCIN:354779
database_cross_reference: RCD:B18y.
database_cross_reference: RCD:B18yz
database_cross_reference: SNOMEDCT_US:187808008
database_cross_reference: SNOMEDCT_US:187816004

cardiovascular cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer that located_in the heart and blood vessels.
PMOID: PMO:00026324
Subclass_of: organ system cancer
Synonym: Cardiovascular Neoplasm
Synonym: Cardiovascular Tumor
Synonym: Cardiovascular tumors
Synonym: Neoplasm cardiovascular
Synonym: Neoplasm of cardiovascular system
Synonym: Neoplasm of cardiovascular system (disorder)
Synonym: Neoplasm of circulatory system
Synonym: Neoplasm;cardiovascular
Synonym: cardiovascular neoplasm
Synonym: neoplasm of the cardiovascular system
Tree Number: T10.2.1.2.7
database_cross_reference: AOD:0000004563
database_cross_reference: AOD:0000023028
database_cross_reference: CSP:2007-0683
database_cross_reference: DO:DOID:176
database_cross_reference: ICPC2EENG:K72
database_cross_reference: ICPC2P:K72004
database_cross_reference: NCI:C4784
database_cross_reference: SNOMEDCT_US:721573003

factitious disorder
type: Class
subclass of: disease of mental health
PMOID: PMO:00028144
Subclass_of: disease of mental health
Synonym: 9-84 FACTITIOUS DISORDERS
Synonym: Disorders, Factitious
Synonym: FACTITIOUS DIS
Synonym: FACTITIOUS DISORDERS
Synonym: Factitious Disorder
Synonym: Factitious Disorders
Synonym: Factitious Disorders [Disease/Finding]
Synonym: Factitious disorder
Synonym: Factitious disorder (disorder)
Synonym: Factitious disorder NOS
Tree Number: T10.3.10
database_cross_reference: CHV:0000004853
database_cross_reference: DSM-5:300.19
database_cross_reference: DSM-5:F68.10
database_cross_reference: ICD10:F68.1
database_cross_reference: ICD10AM:F68.1
database_cross_reference: ICD10CM:F68.1
database_cross_reference: ICD10CM:F68.10
database_cross_reference: LCH_NW:sh93000060
database_cross_reference: MDR:10016068
database_cross_reference: MDR:10016072
database_cross_reference: MDR:10016073
database_cross_reference: MDR:10061595
database_cross_reference: MEDCIN:32831
database_cross_reference: MSH:D005162
database_cross_reference: MTHICD9:300.19
database_cross_reference: NCI:C92198
database_cross_reference: NDFRT:N0000001198
database_cross_reference: PSY:19035
database_cross_reference: RCD:Eu6y1
database_cross_reference: RCD:X00TB
database_cross_reference: RCDSY:Eu6y1
database_cross_reference: SNMI:D9-84000
database_cross_reference: SNOMEDCT_US:192528009
database_cross_reference: SNOMEDCT_US:50705009

conversion disorder
type: Class
subclass of: somatoform disorder
definition: A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.
PMOID: PMO:00028126
Subclass_of: somatoform disorder
Synonym: CONVERSION DIS
Synonym: CONVERSION DISORDER
Synonym: CONVERSION REACTION
Synonym: Conversion Disorder
Synonym: Conversion Disorder [Disease/Finding]
Synonym: Conversion Disorders
Synonym: Conversion Hysteria
Synonym: Conversion Hysterias
Synonym: Conversion Hysterical Neurosis
Synonym: Conversion Neurosis
Tree Number: T10.3.6.1
database_cross_reference: AOD:0000006590
database_cross_reference: AOD:0000023934
database_cross_reference: CCPSS:0052909
database_cross_reference: CCPSS:0059297
database_cross_reference: CHV:0000003333
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2482-7019
database_cross_reference: CST:HYSTERIA
database_cross_reference: CST:NEUROSIS
database_cross_reference: DO:DOID:1768
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:F44
database_cross_reference: ICD9CM:300.11
database_cross_reference: ICPC2P:P75001
database_cross_reference: ICPC2P:P75015
database_cross_reference: LCH_NW:sh85031703
database_cross_reference: MDR:10010893
database_cross_reference: MDR:10010894
database_cross_reference: MDR:10010895
database_cross_reference: MDR:10010896
database_cross_reference: MDR:10021155
database_cross_reference: MDR:10029335
database_cross_reference: MDR:10037942
database_cross_reference: MEDCIN:32794
database_cross_reference: MSH:D003291
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:300.11
database_cross_reference: NDFRT:N0000000846
database_cross_reference: PSY:11717
database_cross_reference: PSY:11720
database_cross_reference: PSY:11730
database_cross_reference: PSY:24200
database_cross_reference: RCD:E201.
database_cross_reference: SNM:D-9233
database_cross_reference: SNM:F-95400
database_cross_reference: SNMI:D9-82030
database_cross_reference: SNMI:F-952A0
database_cross_reference: SNOMEDCT_US:20734000
database_cross_reference: SNOMEDCT_US:44376007
database_cross_reference: SNOMEDCT_US:89239005

vascular disease
type: Class
subclass of: cardiovascular system disease
definition: A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.
PMOID: PMO:00031822
Subclass_of: cardiovascular system disease
Synonym: 322-324 ANEURYSMS
Synonym: ANEURYSM
Synonym: ANEURYSMS
Synonym: Aneurysm
Synonym: Aneurysm (disorder)
Synonym: Aneurysm (morphologic abnormality)
Synonym: Aneurysm - lesion
Synonym: Aneurysm - lesion (qualifier value)
Synonym: Aneurysm NOS
Synonym: Aneurysm NOS (disorder)
Tree Number: T10.8.3.3
database_cross_reference: AOD:0000005337
database_cross_reference: CCPSS:0001782
database_cross_reference: CHV:0000001160
database_cross_reference: COSTAR:U000032
database_cross_reference: CSP:0571-0418
database_cross_reference: CST:ANOMALY VASCUL
database_cross_reference: DO:DOID:178
database_cross_reference: DXP:U000176
database_cross_reference: HPO:HP:0002617
database_cross_reference: ICD10:I72.9
database_cross_reference: ICD10AM:I72.9
database_cross_reference: ICD10CM:I72.9
database_cross_reference: ICD9CM:442.9
database_cross_reference: LCH:U000242
database_cross_reference: LCH_NW:sh85004986
database_cross_reference: MDR:10002329
database_cross_reference: MDR:10002360
database_cross_reference: MEDCIN:210319
database_cross_reference: MEDLINEPLUS:141
database_cross_reference: MSH:D000783
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26693
database_cross_reference: NCI_CDISC:C26693
database_cross_reference: NCI_FDA:1708
database_cross_reference: NCI_NICHD:C26693
database_cross_reference: NDFRT:N0000000403
database_cross_reference: OMIM:MTHU044974
database_cross_reference: PSY:02500
database_cross_reference: RCD:G72z.
database_cross_reference: RCD:XaB0x
database_cross_reference: SNM:M-32400
database_cross_reference: SNM:U000297
database_cross_reference: SNMI:M-32200
database_cross_reference: SNOMEDCT_US:134342004
database_cross_reference: SNOMEDCT_US:155425005
database_cross_reference: SNOMEDCT_US:155428007
database_cross_reference: SNOMEDCT_US:195292009
database_cross_reference: SNOMEDCT_US:362727005
database_cross_reference: SNOMEDCT_US:432119003
database_cross_reference: SNOMEDCT_US:85659009

pericarditis
type: Class
subclass of: pericardium disease
definition: A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain.
PMOID: PMO:00031600
Subclass_of: pericardium disease
Synonym: PERICARDITIS
Synonym: Pericarditis
Synonym: Pericarditis (disorder)
Synonym: Pericarditis NOS
Synonym: Pericarditis [Disease/Finding]
Synonym: Pericarditis, NOS
Synonym: an inflammation of the membrane surrounding the heart
Synonym: pericarditis (diagnosis)
Tree Number: T10.8.3.1.1
database_cross_reference: AOD:0000005398
database_cross_reference: BI:BI00129
database_cross_reference: CCPSS:1018031
database_cross_reference: CHV:0000009488
database_cross_reference: COSTAR:574
database_cross_reference: CSP:1390-3467
database_cross_reference: CSP:1393-3247
database_cross_reference: CST:PERICARDITIS
database_cross_reference: DO:DOID:1787
database_cross_reference: DXP:U003078
database_cross_reference: HPO:HP:0001701
database_cross_reference: LCH:U003548
database_cross_reference: LCH_NW:sh85099850
database_cross_reference: LNC:LA7462-0
database_cross_reference: MDR:10034484
database_cross_reference: MDR:10034495
database_cross_reference: MEDCIN:33353
database_cross_reference: MEDLINEPLUS:5664
database_cross_reference: MSH:D010493
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:420.90
database_cross_reference: NCI:C34915
database_cross_reference: NCI_CTCAE:E10180
database_cross_reference: NCI_NICHD:C34915
database_cross_reference: NDFRT:N0000002362
database_cross_reference: OMIM:MTHU011706
database_cross_reference: RCD:X201j
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D3-91000
database_cross_reference: SNOMEDCT_US:3238004

malignant mesothelioma
type: Class
subclass of: cell type cancer
PMOID: PMO:00025404
Subclass_of: cell type cancer
Synonym: Cancer, mesothelioma
Synonym: MESOM
Synonym: MESOTHELIOMA, MALIGNANT
Synonym: Malignant Mesothelial Neoplasm
Synonym: Malignant Mesothelial Tumor
Synonym: Malignant Mesothelioma
Synonym: Malignant Neoplasm of Mesothelium
Synonym: Malignant Neoplasm of the Mesothelium
Synonym: Malignant Tumor of Mesothelium
Synonym: Malignant Tumor of the Mesothelium
Tree Number: T10.2.1.1.8
database_cross_reference: CHV:0000031033
database_cross_reference: HPO:HP:0100001
database_cross_reference: ICD10AM:M9050/3
database_cross_reference: MDR:10027407
database_cross_reference: MDR:10027410
database_cross_reference: MEDCIN:335197
database_cross_reference: MEDLINEPLUS:4014
database_cross_reference: MSH:C562839
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4456
database_cross_reference: NCI_CDISC:C4456
database_cross_reference: NCI_NCI-GLOSS:CDR0000044992
database_cross_reference: OMIM:156240
database_cross_reference: OMIM:MTHU053483
database_cross_reference: PDQ:CDR0000038142
database_cross_reference: RCD:BBP1.
database_cross_reference: SNM:M-9050/3
database_cross_reference: SNMI:M-90503
database_cross_reference: SNOMEDCT_US:109378008
database_cross_reference: SNOMEDCT_US:62064005
database_cross_reference: SNOMEDCT_VET:109378008

urinary system disease
type: Class
subclass of: disease of anatomical entity
PMOID: PMO:00032954
Subclass_of: disease of anatomical entity
Synonym: DISEASES AND SYNDROMES OF THE URINARY TRACT
Synonym: DISORDER URINARY TRACT
Synonym: Disease of urinary tract
Synonym: Disease of urinary tract (disorder)
Synonym: Disease of urinary tract, NOS
Synonym: Disease or syndrome of urinary tract
Synonym: Disease, Urinary Tract
Synonym: Disease, Urologic
Synonym: Disease, Urological
Synonym: Disease;urological
Tree Number: T10.8.7
database_cross_reference: AOD:0000005848
database_cross_reference: AOD:0000023502
database_cross_reference: CCPSS:0035307
database_cross_reference: CHV:0000012806
database_cross_reference: CHV:0000039968
database_cross_reference: CSP:3045-8726
database_cross_reference: CST:UG/UT
database_cross_reference: CST:URIN TRACT DIS
database_cross_reference: ICD10:N39.9
database_cross_reference: ICD10AM:N39.9
database_cross_reference: ICD10CM:N39.9
database_cross_reference: ICD9CM:599.9
database_cross_reference: ICPC2P:U99027
database_cross_reference: MDR:10013278
database_cross_reference: MDR:10038359
database_cross_reference: MDR:10045836
database_cross_reference: MDR:10046566
database_cross_reference: MDR:10046567
database_cross_reference: MDR:10046568
database_cross_reference: MDR:10046709
database_cross_reference: MEDCIN:210520
database_cross_reference: MEDCIN:30628
database_cross_reference: MEDCIN:363346
database_cross_reference: MSH:D014570
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3430
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NICHD:C3430
database_cross_reference: NDFRT:N0000003086
database_cross_reference: RCD:K19yw
database_cross_reference: RCD:X30Hb
database_cross_reference: RCD:XaB5r
database_cross_reference: SNM:D-6500
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D7-10000
database_cross_reference: SNOMEDCT_US:128606002
database_cross_reference: SNOMEDCT_US:155848006
database_cross_reference: SNOMEDCT_US:155903006
database_cross_reference: SNOMEDCT_US:197951006
database_cross_reference: SNOMEDCT_US:266612003
database_cross_reference: SNOMEDCT_US:307415006
database_cross_reference: SNOMEDCT_US:41368006

Menkes disease
type: Class
subclass of: hair disease
subclass of: metal metabolism disorder
PMOID: PMO:00029030
Subclass_of: hair disease
Subclass_of: metal metabolism disorder
Synonym: CONGEN HYPOCUPREMIA
Synonym: COPPER TRANSPORT DISEASE
Synonym: Congenital Hypocupremia
Synonym: Congenital Hypocupremias
Synonym: Congenital hypocupraemia
Synonym: Congenital hypocupremia
Synonym: Copper Transport Disease
Synonym: Copper transport disease
Synonym: Disease, Steely Hair
Synonym: Diseases, Kinky Hair
Tree Number: T10.6.2.4.8
Tree Number: T10.8.12.3.3
database_cross_reference: CCPSS:0014848
database_cross_reference: CHV:0000007116
database_cross_reference: CSP:1849-5365
database_cross_reference: DO:DOID:1838
database_cross_reference: JABL:422
database_cross_reference: MDR:10023452
database_cross_reference: MDR:10027292
database_cross_reference: MDR:10027293
database_cross_reference: MDR:10027294
database_cross_reference: MEDCIN:33628
database_cross_reference: MSH:D007706
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75486
database_cross_reference: NCI_NICHD:C75486
database_cross_reference: NDFRT:N0000001757
database_cross_reference: OMIM:300011
database_cross_reference: OMIM:309400
database_cross_reference: RCD:PKy92
database_cross_reference: SNM:D-3524
database_cross_reference: SNMI:D6-32110
database_cross_reference: SNOMEDCT_US:59178007

impotence
type: Class
subclass of: sexual dysfunction
PMOID: PMO:00028148
Subclass_of: sexual dysfunction
Synonym: Dysfunction, Erectile
Synonym: Dysfunction;erection
Synonym: Dysfunction;sexual;impotence
Synonym: ED
Synonym: ERECTILE DYSFUNCTION
Synonym: Erectile Dysfunction
Synonym: Erectile Dysfunction [Disease/Finding]
Synonym: Erectile disorder
Synonym: Erectile disturbance
Synonym: Erectile dysfunction
Tree Number: T10.3.11.1.1
database_cross_reference: AOD:0000005859
database_cross_reference: AOD:0000006832
database_cross_reference: BI:BI00445
database_cross_reference: CCPSS:0042371
database_cross_reference: CCPSS:0048456
database_cross_reference: CHV:0000006627
database_cross_reference: CHV:0000024784
database_cross_reference: CHV:0000049990
database_cross_reference: CHV:0000050417
database_cross_reference: COSTAR:409
database_cross_reference: CSP:2695-3272
database_cross_reference: CST:IMPOTENCE
database_cross_reference: DO:DOID:1875
database_cross_reference: DSM-5:302.72
database_cross_reference: DSM-5:F52.21
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002080
database_cross_reference: HPO:HP:0000802
database_cross_reference: ICD10CM:F52.21
database_cross_reference: ICD10CM:N52
database_cross_reference: ICD10CM:N52.9
database_cross_reference: ICPC2EENG:Y07
database_cross_reference: ICPC2P:Y07003
database_cross_reference: ICPC2P:Y08006
database_cross_reference: LCH:U002393
database_cross_reference: LCH_NW:sh85064658
database_cross_reference: MDR:10015116
database_cross_reference: MDR:10015118
database_cross_reference: MDR:10021550
database_cross_reference: MDR:10021552
database_cross_reference: MDR:10025503
database_cross_reference: MDR:10052003
database_cross_reference: MDR:10061461
database_cross_reference: MEDCIN:338173
database_cross_reference: MEDCIN:35819
database_cross_reference: MEDLINEPLUS:118
database_cross_reference: MSH:D007172
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:302.72
database_cross_reference: NCI:C3133
database_cross_reference: NCI:C34801
database_cross_reference: NCI_CTCAE:E13088
database_cross_reference: NCI_FDA:1925
database_cross_reference: NCI_NCI-GLOSS:CDR0000046351
database_cross_reference: NCI_NCI-GLOSS:CDR0000321372
database_cross_reference: NCI_NCI-GLOSS:CDR0000321376
database_cross_reference: NCI_NICHD:C34801
database_cross_reference: NDFRT:N0000001672
database_cross_reference: OMIM:MTHU002521
database_cross_reference: OMIM:MTHU026591
database_cross_reference: PSY:24630
database_cross_reference: RCD:E2273
database_cross_reference: SNM:F-98700
database_cross_reference: SNMI:D9-73522
database_cross_reference: SNMI:F-9B730
database_cross_reference: SNOMEDCT_US:154905005
database_cross_reference: SNOMEDCT_US:192466005
database_cross_reference: SNOMEDCT_US:23781003
database_cross_reference: SNOMEDCT_US:268762007
database_cross_reference: SNOMEDCT_US:33967003
database_cross_reference: SNOMEDCT_US:367115006
database_cross_reference: SNOMEDCT_US:397803000
database_cross_reference: SNOMEDCT_US:398175007

sexual dysfunction
type: Class
subclass of: sexual disorder
definition: A disease of mental health that involves the impairment in normal sexual functioning.
PMOID: PMO:00028147
Subclass_of: sexual disorder
Synonym: Abnormal sexual function
Synonym: Abnormal sexual function (finding)
Synonym: Decreased sexual function
Synonym: Decreased sexual function (finding)
Synonym: Dysfunction;sexual
Synonym: Impaired sexual function
Synonym: SEX DYSFUNCTION
Synonym: SEXUAL DISORDER
Synonym: SEXUAL DYSFUNCTION
Synonym: SEXUAL FUNCTION ABNORMAL
Tree Number: T10.3.11.1
database_cross_reference: AOD:0000023510
database_cross_reference: BI:BI00466
database_cross_reference: CCPSS:0037451
database_cross_reference: CCPSS:1011989
database_cross_reference: CHV:0000011268
database_cross_reference: CHV:0000039020
database_cross_reference: COSTAR:676
database_cross_reference: CST:GUSEXDYS
database_cross_reference: CST:GYNSEX
database_cross_reference: CST:SEX FUNC ABNORM
database_cross_reference: DO:DOID:0060043
database_cross_reference: DO:DOID:1876
database_cross_reference: DSM-5:302.70
database_cross_reference: DSM-5:F52.9
database_cross_reference: ICD10CM:F52.9
database_cross_reference: ICD10CM:R37
database_cross_reference: ICPC2P:P08013
database_cross_reference: LCH_NW:sh85120728
database_cross_reference: LNC:MTHU013434
database_cross_reference: MDR:10040476
database_cross_reference: MDR:10040477
database_cross_reference: MDR:10040479
database_cross_reference: MDR:10040482
database_cross_reference: MDR:10052413
database_cross_reference: MEDCIN:314376
database_cross_reference: MEDCIN:32828
database_cross_reference: MEDCIN:36302
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:302.70
database_cross_reference: MTHICD9:302.9
database_cross_reference: NCI:C3347
database_cross_reference: NCI_NICHD:C3347
database_cross_reference: RCD:Ua1sq
database_cross_reference: RCD:X00TF
database_cross_reference: SNMI:D9-73500
database_cross_reference: SNMI:F-0B700
database_cross_reference: SNMI:F-9B222
database_cross_reference: SNOMEDCT_US:225723003
database_cross_reference: SNOMEDCT_US:231532002
database_cross_reference: SNOMEDCT_US:39894007
database_cross_reference: SNOMEDCT_US:56925008
database_cross_reference: SNOMEDCT_US:65655009

hepatitis C
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.
PMOID: PMO:00029375
Subclass_of: viral infectious disease
Synonym: HEPATITIS C
Synonym: HEPATITIS NON A NON B
Synonym: HEPATITIS, NON-A, NON-B
Synonym: Hep non-A non-B
Synonym: Hepatitis (non-A non-B)
Synonym: Hepatitis C
Synonym: Hepatitis C (disorder)
Synonym: Hepatitis C Infection
Synonym: Hepatitis C [Disease/Finding]
Synonym: Hepatitis non-A non-B
Tree Number: T10.7.2.25
database_cross_reference: AOD:0000004804
database_cross_reference: AOD:0000004812
database_cross_reference: BI:BI00263
database_cross_reference: CCPSS:1005849
database_cross_reference: CCPSS:1017956
database_cross_reference: CHV:0000006059
database_cross_reference: CHV:0000057900
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:4000-0219
database_cross_reference: CSP:4006-0046
database_cross_reference: DO:DOID:1883
database_cross_reference: DXP:U000818
database_cross_reference: ICD10CM:B19.2
database_cross_reference: ICD10CM:B19.20
database_cross_reference: ICD9CM:070.7
database_cross_reference: ICPC2P:D72008
database_cross_reference: LCH:U005633
database_cross_reference: LCH_NW:sh85060290
database_cross_reference: LNC:LA19423-5
database_cross_reference: MDR:10019620
database_cross_reference: MDR:10019718
database_cross_reference: MDR:10019744
database_cross_reference: MDR:10019786
database_cross_reference: MDR:10029526
database_cross_reference: MDR:10047457
database_cross_reference: MEDCIN:30155
database_cross_reference: MSH:D006526
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:070.70
database_cross_reference: NCI:C3098
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044139
database_cross_reference: NDFRT:N0000001509
database_cross_reference: RCD:A7054
database_cross_reference: RCD:A70z0
database_cross_reference: SNM:D-0524
database_cross_reference: SNMI:DE-38100
database_cross_reference: SNOMEDCT_US:123324009
database_cross_reference: SNOMEDCT_US:154349000
database_cross_reference: SNOMEDCT_US:186634008
database_cross_reference: SNOMEDCT_US:186643004
database_cross_reference: SNOMEDCT_US:50711007

viral hepatitis
type: Class
subclass of: viral infectious disease
definition: A hepatitis that involves viral infection causing inflammation of the liver.
PMOID: PMO:00029418
Subclass_of: viral infectious disease
Synonym: HEPATITIS VIRAL
Synonym: Hepatic viral infections
Synonym: Hepatitis viral
Synonym: Hepatitis viral NOS
Synonym: Hepatitis;viral
Synonym: Unspecified viral hepatitis
Synonym: Unspecified viral hepatitis (disorder)
Synonym: VH - Viral hepatitis
Synonym: VIRAL HEPATITIS
Synonym: VIRUS HEPATITIS
Tree Number: T10.7.2.53
database_cross_reference: AOD:0000004801
database_cross_reference: AOD:0000023161
database_cross_reference: BI:BI00264
database_cross_reference: CCPSS:1017962
database_cross_reference: CHV:0000013008
database_cross_reference: COSTAR:U000722
database_cross_reference: CST:HEPATITIS
database_cross_reference: DO:DOID:1884
database_cross_reference: HPO:HP:0006562
database_cross_reference: ICD10:B15-B19.9
database_cross_reference: ICD10:B19
database_cross_reference: ICD10AM:B15-B19.9
database_cross_reference: ICD10AM:B19
database_cross_reference: ICD10CM:B15-B19
database_cross_reference: ICD10CM:B19
database_cross_reference: ICD10CM:B19.9
database_cross_reference: ICD9CM:070
database_cross_reference: ICPC2EENG:D72
database_cross_reference: ICPC2P:D72005
database_cross_reference: LNC:MTHU020837
database_cross_reference: MDR:10019715
database_cross_reference: MDR:10019799
database_cross_reference: MDR:10019800
database_cross_reference: MDR:10047446
database_cross_reference: MDR:10047459
database_cross_reference: MDR:10047460
database_cross_reference: MDR:10047489
database_cross_reference: MEDCIN:334594
database_cross_reference: MEDLINEPLUS:109
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:070.9
database_cross_reference: NCI:C35124
database_cross_reference: NCI_CTCAE:E11410
database_cross_reference: NCI_NICHD:C35124
database_cross_reference: OMIM:MTHU014247
database_cross_reference: RCD:A70..
database_cross_reference: RCD:A70z.
database_cross_reference: SNM:D-0520
database_cross_reference: SNMI:DE-38200
database_cross_reference: SNOMEDCT_US:154346007
database_cross_reference: SNOMEDCT_US:186642009
database_cross_reference: SNOMEDCT_US:187432005
database_cross_reference: SNOMEDCT_US:3738000

melanoma
type: Class
subclass of: cell type cancer
definition: A skin cancer that has_material_basis_in melanocytes.
PMOID: PMO:00025304
Subclass_of: cell type cancer
Synonym: Cutaneous melanoma
Synonym: MALIGNANT MELANOMA
Synonym: MELANOMA
Synonym: MELANOMA MALIGNANT
Synonym: MELANOMA, MALIGNANT
Synonym: MM - Malignant melanoma
Synonym: Malignant Melanoma
Synonym: Malignant Melanomas
Synonym: Malignant melanoma
Synonym: Malignant melanoma (disorder)
Tree Number: T10.2.1.1.3
database_cross_reference: AOD:0000004558
database_cross_reference: BI:BI00601
database_cross_reference: CHV:0000007894
database_cross_reference: COSTAR:467
database_cross_reference: COSTAR:475
database_cross_reference: CSP:2020-2434
database_cross_reference: CST:MELANOMA SKIN
database_cross_reference: DO:DOID:1909
database_cross_reference: DO:DOID:8923
database_cross_reference: DXP:U001151
database_cross_reference: HPO:HP:0002861
database_cross_reference: HPO:HP:0012056
database_cross_reference: ICD10AM:M8720/3
database_cross_reference: ICPC2P:S77003
database_cross_reference: LCH:U002889
database_cross_reference: LCH_NW:sh85083381
database_cross_reference: LNC:LA14279-6
database_cross_reference: MDR:10025650
database_cross_reference: MDR:10027150
database_cross_reference: MDR:10053571
database_cross_reference: MEDCIN:352914
database_cross_reference: MEDLINEPLUS:321
database_cross_reference: MSH:D008545
database_cross_reference: MTH:475
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3224
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3224
database_cross_reference: NCI_CTEP-SDC:10053571
database_cross_reference: NCI_NCI-GLOSS:CDR0000045135
database_cross_reference: NCI_NICHD:C3224
database_cross_reference: NDFRT:N0000001969
database_cross_reference: OMIM:MTHU000127
database_cross_reference: OMIM:MTHU001388
database_cross_reference: PDQ:CDR0000038833
database_cross_reference: RCD:XE1wX
database_cross_reference: RCD:Xa99S
database_cross_reference: RCDSY:XE1wX
database_cross_reference: SNM:D-2946
database_cross_reference: SNM:M-8720/3
database_cross_reference: SNMI:M-87203
database_cross_reference: SNOMEDCT_US:154501005
database_cross_reference: SNOMEDCT_US:189749008
database_cross_reference: SNOMEDCT_US:2092003
database_cross_reference: SNOMEDCT_US:269503007
database_cross_reference: SNOMEDCT_US:269577007
database_cross_reference: SNOMEDCT_US:372244006
database_cross_reference: SNOMEDCT_VET:309331000009104

Lesch-Nyhan syndrome
type: Class
subclass of: purine-pyrimidine metabolic disorder
PMOID: PMO:00029165
Subclass_of: purine-pyrimidine metabolic disorder
Synonym: COMPLETE HGPRT DEFIC DIS
Synonym: Choreoathetosis Self Mutilation Hyperuricemia Syndrome
Synonym: Choreoathetosis Self Mutilation Syndrome
Synonym: Choreoathetosis Self-Mutilation Hyperuricemia Syndrome
Synonym: Choreoathetosis Self-Mutilation Syndrome
Synonym: Choreoathetosis Self-Mutilation Syndromes
Synonym: Choreoathetosis self-mutilation syndrome
Synonym: Comp hypoxan-guan phosribo def
Synonym: Complete HGPRT Deficiency Disease
Synonym: Complete HGPRT deficiency
Tree Number: T10.6.2.14.3
database_cross_reference: CHV:0000007321
database_cross_reference: CSP:1849-8105
database_cross_reference: DO:DOID:1919
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001042
database_cross_reference: ICD10:E79.1
database_cross_reference: ICD10AM:E79.1
database_cross_reference: ICD10CM:E79.1
database_cross_reference: JABL:398
database_cross_reference: LCH:U002658
database_cross_reference: LCH_NW:sh85076163
database_cross_reference: MDR:10024245
database_cross_reference: MDR:10057589
database_cross_reference: MDR:10075774
database_cross_reference: MDR:10075792
database_cross_reference: MEDCIN:33537
database_cross_reference: MSH:D007926
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.2
database_cross_reference: NCI:C61255
database_cross_reference: NDFRT:N0000001813
database_cross_reference: OMIM:300322
database_cross_reference: OMIM:308000
database_cross_reference: RCD:X40UY
database_cross_reference: RCD:XE11n
database_cross_reference: SNM:D-1204
database_cross_reference: SNMI:D6-40400
database_cross_reference: SNMI:D6-40410
database_cross_reference: SNMI:D6-40420
database_cross_reference: SNOMEDCT_US:10406007
database_cross_reference: SNOMEDCT_US:124275001
database_cross_reference: SNOMEDCT_US:190917005
database_cross_reference: SNOMEDCT_US:190918000
database_cross_reference: SNOMEDCT_US:190921003
database_cross_reference: SNOMEDCT_US:267451005
database_cross_reference: SNOMEDCT_US:68655008
database_cross_reference: SNOMEDCT_US:90924007

hyperuricemia
type: Class
subclass of: acquired metabolic disease
definition: An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood.
PMOID: PMO:00028946
Subclass_of: acquired metabolic disease
Synonym: Blood urate raized
Synonym: HYPERURICAEMIA
Synonym: HYPERURICEMIA
Synonym: High blood uric acid level
Synonym: Hyperuricaemia
Synonym: Hyperuricaemia (disorder)
Synonym: Hyperuricaemia [Ambiguous]
Synonym: Hyperuricaemic
Synonym: Hyperuricemia
Synonym: Hyperuricemia (disorder)
Tree Number: T10.6.1.6
database_cross_reference: BI:BI00350
database_cross_reference: CCPSS:0048739
database_cross_reference: CHV:0000047106
database_cross_reference: COSTAR:400
database_cross_reference: CSP:1849-8097
database_cross_reference: CST:HYPERURICEM
database_cross_reference: DO:DOID:1920
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002038
database_cross_reference: HPO:HP:0002149
database_cross_reference: ICPC2P:A91023
database_cross_reference: ICPC2P:T94006
database_cross_reference: LCH_NW:sh85063735
database_cross_reference: LNC:LP200321-0
database_cross_reference: LNC:MTHU050770
database_cross_reference: MDR:10020903
database_cross_reference: MDR:10020904
database_cross_reference: MDR:10020907
database_cross_reference: MDR:10046507
database_cross_reference: MEDCIN:363338
database_cross_reference: MEDLINEPLUS:264
database_cross_reference: MSH:D033461
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000355
database_cross_reference: NCI:C3961
database_cross_reference: NCI_CTCAE:E12305
database_cross_reference: NCI_NCI-GLOSS:CDR0000045466
database_cross_reference: NCI_NICHD:C3961
database_cross_reference: NDFRT:N0000010234
database_cross_reference: OMIM:MTHU004766
database_cross_reference: PDQ:CDR0000042380
database_cross_reference: RCD:X40PQ
database_cross_reference: RCDAE:X40PQ
database_cross_reference: SNM:F-11473
database_cross_reference: SNMI:D6-40201
database_cross_reference: SNOMEDCT_US:144021008
database_cross_reference: SNOMEDCT_US:166733000
database_cross_reference: SNOMEDCT_US:237857006
database_cross_reference: SNOMEDCT_US:271198001
database_cross_reference: SNOMEDCT_US:35885006

Klinefelter's syndrome
type: Class
subclass of: chromosomal disease
PMOID: PMO:00028776
Subclass_of: chromosomal disease
Synonym: 47,XXY complex intersex
Synonym: 47,XXY complex intersex (diagnosis)
Synonym: Hypogonadism, primary
Synonym: Hypogonadotropic Hypogonadism
Synonym: KLINEFELTER DISEASE
Synonym: KLINEFELTER SYNDROME
Synonym: KLINEFELTER'S SYNDROME
Synonym: Klinefelter Syndrome
Synonym: Klinefelter Syndrome [Disease/Finding]
Synonym: Klinefelter Syndromes
Tree Number: T10.5.9.7
database_cross_reference: CCPSS:0043108
database_cross_reference: CHV:0000007121
database_cross_reference: COSTAR:U000399
database_cross_reference: COSTAR:U000735
database_cross_reference: CSP:1254-8437
database_cross_reference: DO:DOID:1921
database_cross_reference: DXP:U000993
database_cross_reference: DXP:U002258
database_cross_reference: ICD10:Q98.0
database_cross_reference: ICD10:Q98.4
database_cross_reference: ICD10AM:Q98.0
database_cross_reference: ICD10AM:Q98.4
database_cross_reference: ICD10CM:Q98.0
database_cross_reference: ICD10CM:Q98.4
database_cross_reference: ICD9CM:758.7
database_cross_reference: ICPC2P:A90007
database_cross_reference: JABL:226
database_cross_reference: LCH:U002589
database_cross_reference: LCH_NW:sh85072641
database_cross_reference: MDR:10023463
database_cross_reference: MDR:10048229
database_cross_reference: MEDCIN:30414
database_cross_reference: MEDCIN:30423
database_cross_reference: MEDCIN:313993
database_cross_reference: MEDCIN:331316
database_cross_reference: MEDLINEPLUS:1524
database_cross_reference: MSH:D007713
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:758.7
database_cross_reference: NCI:C34752
database_cross_reference: NCI_NCI-GLOSS:CDR0000304688
database_cross_reference: NCI_NICHD:C34752
database_cross_reference: NDFRT:N0000001759
database_cross_reference: OMIM:MTHU028322
database_cross_reference: OMIM:MTHU032889
database_cross_reference: PSY:27430
database_cross_reference: RCD:PJ7..
database_cross_reference: RCD:PJ70.
database_cross_reference: RCD:PJ7z.
database_cross_reference: SNM:D-5761
database_cross_reference: SNMI:D4-02252
database_cross_reference: SNOMEDCT_US:157021007
database_cross_reference: SNOMEDCT_US:205696000
database_cross_reference: SNOMEDCT_US:205701007
database_cross_reference: SNOMEDCT_US:205712007
database_cross_reference: SNOMEDCT_US:22053006
database_cross_reference: SNOMEDCT_US:268357008
database_cross_reference: SNOMEDCT_US:405769009
database_cross_reference: SNOMEDCT_US:405770005

sex differentiation disease
type: Class
subclass of: gonadal disease
PMOID: PMO:00033115
Subclass_of: gonadal disease
Synonym: Disorder of sex development
Synonym: Disorders of Sex Development
Synonym: Disorders of Sex Development [Disease/Finding]
Synonym: Disorders of Sexual Development
Synonym: Sex Development Disorder
Synonym: Sex Development Disorders
Synonym: Sexual Development Disorder
Synonym: Sexual Development Disorders
Synonym: disorder of sexual differentiation
Synonym: sex development disorder
Tree Number: T10.8.8.2.2
database_cross_reference: CSP:2586-8784
database_cross_reference: DO:DOID:1923
database_cross_reference: MDR:10070597
database_cross_reference: MSH:D012734
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002722

hypogonadism
type: Class
subclass of: gonadal disease
definition: A gonadal disease that is characterized by diminished functional activity of the gonads.
PMOID: PMO:00033123
Subclass_of: gonadal disease
Synonym: Decreased activity of gonads
Synonym: HYPOGONADISM
Synonym: Hypogonadism
Synonym: Hypogonadism (disorder)
Synonym: Hypogonadism [Disease/Finding]
Synonym: Hypogonadism, NOS
Synonym: Hypogonadotropism
Synonym: hypogonadism (diagnosis)
Synonym: hypogonadotropism
Tree Number: T10.8.8.2.3
database_cross_reference: AOD:0000005865
database_cross_reference: CCPSS:1013140
database_cross_reference: CHV:0000006477
database_cross_reference: CHV:0000052805
database_cross_reference: COSTAR:U000373
database_cross_reference: CSP:2586-8835
database_cross_reference: DO:DOID:1924
database_cross_reference: DO:DOID:7455
database_cross_reference: DXP:U002049
database_cross_reference: HPO:HP:0000135
database_cross_reference: ICPC2P:T99032
database_cross_reference: LCH:U002330
database_cross_reference: LCH_NW:sh85063790
database_cross_reference: MDR:10058359
database_cross_reference: MEDCIN:30700
database_cross_reference: MSH:D007006
database_cross_reference: NCI:C9227
database_cross_reference: NDFRT:N0000001636
database_cross_reference: OMIM:MTHU000132
database_cross_reference: PSY:24000
database_cross_reference: RCD:X40Ov
database_cross_reference: SNMI:DB-12702
database_cross_reference: SNOMEDCT_US:48130008

Coffin-Siris syndrome
type: Class
subclass of: genetic disease
definition: A genetic disease that is characterized by underdevelopment of the tips of fingers or toes, underdevelopment or abscense of finger or toe nails and developmental disability.
PMOID: PMO:00028752
Subclass_of: genetic disease
Synonym: COFFIN-SIRIS SYNDROME
Synonym: CSS
Synonym: CSS1
Synonym: Coffin-Siris Syndrome
Synonym: Coffin-Siris syndrome (disorder)
Synonym: Coffin-Siris syndrome 1
Synonym: Dwarfism-Onychodysplasia
Synonym: FIFTH DIGIT SYNDROME
Synonym: Fifth Digit Syndrome
Synonym: Fifth digit syndrome
Tree Number: T10.5.6
database_cross_reference: CHV:0000025897
database_cross_reference: DO:DOID:0070042
database_cross_reference: DO:DOID:1925
database_cross_reference: JABL:239
database_cross_reference: MEDCIN:314847
database_cross_reference: MSH:C536436
database_cross_reference: NCI:C35321
database_cross_reference: OMIM:135900
database_cross_reference: RCD:X50HX
database_cross_reference: SNM:D-5346
database_cross_reference: SNMI:D4-01201
database_cross_reference: SNOMEDCT_US:10007009

Williams-Beuren syndrome
type: Class
subclass of: chromosomal deletion syndrome
PMOID: PMO:00028805
Subclass_of: chromosomal deletion syndrome
Synonym: Aortic Stenoses, Hypercalcemia-Supravalvar
Synonym: Aortic Stenosis, Hypercalcemia-Supravalvar
Synonym: Beuren Syndrome
Synonym: Beuren syndrome
Synonym: CHROMOSOME 7q11.23 DELETION SYNDROME, 1.5- TO 1.8-MB
Synonym: Chromosome 7q11.23 Deletion Syndrome
Synonym: Contiguous Gene Syndrome, Williams
Synonym: Fanconi Schlesinger syndrome
Synonym: Fanconi-Schlesinger syndrome
Synonym: HYPERCALCEMIA, INFANTILE IDIOPATHIC
Tree Number: T10.5.9.8.28
database_cross_reference: CHV:0000018179
database_cross_reference: CSP:4006-0100
database_cross_reference: DO:DOID:1928
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000870
database_cross_reference: JABL:656
database_cross_reference: LCH_NW:sh98004230
database_cross_reference: MDR:10049644
database_cross_reference: MEDCIN:36058
database_cross_reference: MSH:D018980
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85232
database_cross_reference: NCI_NICHD:C85232
database_cross_reference: NDFRT:N0000003884
database_cross_reference: OMIM:194050
database_cross_reference: PSY:56764
database_cross_reference: RCD:PKy4.
database_cross_reference: SNM:D-5358
database_cross_reference: SNMI:D4-00301
database_cross_reference: SNOMEDCT_US:63247009

reproductive organ cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer that is manifested in the reproductive organs.
PMOID: PMO:00025521
Subclass_of: organ system cancer
Synonym: Neoplasm of Reproductive System
Synonym: Neoplasm of the Reproductive System
Synonym: Reproductive Neoplasm
Synonym: Reproductive System Neoplasm
Synonym: Reproductive System Tumor
Synonym: Reproductive Tumor
Synonym: Reproductive tumor
Synonym: Tumor of Reproductive System
Synonym: Tumor of the Reproductive System
Synonym: malignant reproductive system neoplasm
Tree Number: T10.2.1.2.2
database_cross_reference: CSP:2016-0492
database_cross_reference: DO:DOID:193
database_cross_reference: NCI:C3674

Angelman syndrome
type: Class
subclass of: chromosomal disease
PMOID: PMO:00028775
Subclass_of: chromosomal disease
Synonym: ANGELMAN SYNDROME
Synonym: AS
Synonym: Angelman Syndrome
Synonym: Angelman Syndrome [Disease/Finding]
Synonym: Angelman syndrome (AS)
Synonym: Angelman syndrome (diagnosis)
Synonym: Angelman syndrome (disorder)
Synonym: Angelman's syndrome
Synonym: Children, Puppet
Synonym: HAPPY PUPPET SYNDROME, FORMERLY
Tree Number: T10.5.9.6
database_cross_reference: CHV:0000017919
database_cross_reference: CSP:4008-0043
database_cross_reference: DO:DOID:1932
database_cross_reference: ICD10CM:Q93.5
database_cross_reference: JABL:32
database_cross_reference: LCH_NW:sh92000322
database_cross_reference: MDR:10049004
database_cross_reference: MDR:10052652
database_cross_reference: MEDCIN:312327
database_cross_reference: MSH:D017204
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75462
database_cross_reference: NCI_NICHD:C75462
database_cross_reference: NDFRT:N0000003551
database_cross_reference: OMIM:105830
database_cross_reference: OMIM:601623
database_cross_reference: RCD:PKyz5
database_cross_reference: SNMI:D4-00624
database_cross_reference: SNOMEDCT_US:76880004

trichomoniasis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively.
PMOID: PMO:00029695
Subclass_of: parasitic protozoa infectious disease
Tree Number: T10.7.4.2.9
database_cross_reference: DO:DOID:1947

fallopian tube disease
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is located_in the fallopian tube.
PMOID: PMO:00029779
Subclass_of: female reproductive system disease
Synonym: Disease, Fallopian Tube
Synonym: Diseases, Fallopian Tube
Synonym: Disorder of fallopian tube
Synonym: FALLOPIAN TUBE DIS
Synonym: Fallopian Tube Disease
Synonym: Fallopian Tube Diseases
Synonym: Fallopian Tube Diseases [Disease/Finding]
Synonym: Fallopian Tube Disorder
Synonym: Fallopian tube disease
Synonym: Fallopian tube disorder
Tree Number: T10.8.1.4.1
database_cross_reference: CHV:0000004876
database_cross_reference: CST:UG/FG/FT
database_cross_reference: DO:DOID:1962
database_cross_reference: LCH_NW:sh2005006502
database_cross_reference: MDR:10052094
database_cross_reference: MEDCIN:90001
database_cross_reference: MSH:D005184
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26771
database_cross_reference: NDFRT:N0000001206
database_cross_reference: RCD:X406c
database_cross_reference: SNOMEDCT_US:128134005
database_cross_reference: SNOMEDCT_VET:128134005

anxiety disorder
type: Class
subclass of: cognitive disorder
definition: A cognitive disorder that involves an excessive, irrational dread of everyday situations.
PMOID: PMO:00028218
Subclass_of: cognitive disorder
Synonym: 9-81 ANXIETY DISORDERS
Synonym: ANXIETY DIS
Synonym: ANXIETY DISORDER
Synonym: ANXIETY DISORDERS
Synonym: Anxiety
Synonym: Anxiety Disorder
Synonym: Anxiety Disorders
Synonym: Anxiety Disorders [Disease/Finding]
Synonym: Anxiety NOS
Synonym: Anxiety disord unspecified
Tree Number: T10.3.12.5
database_cross_reference: AOD:0000023901
database_cross_reference: CCPSS:1018078
database_cross_reference: CHV:0000001343
database_cross_reference: CSP:2483-6220
database_cross_reference: DO:DOID:2030
database_cross_reference: DSM-5:300.00
database_cross_reference: DSM-5:F41.9
database_cross_reference: ICD10:F41.9
database_cross_reference: ICD10AM:F41.9
database_cross_reference: ICD10CM:F41.9
database_cross_reference: ICPC2P:P74002
database_cross_reference: LCH_NW:sh2005006293
database_cross_reference: LNC:MTHU020812
database_cross_reference: MDR:10057666
database_cross_reference: MEDCIN:32791
database_cross_reference: MSH:D001008
database_cross_reference: MTH:058
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2878
database_cross_reference: NCI_CTCAE:C2878
database_cross_reference: NCI_NICHD:C2878
database_cross_reference: NDFRT:N0000000435
database_cross_reference: OMIM:MTHU004077
database_cross_reference: OMIM:MTHU053021
database_cross_reference: PDQ:CDR0000042479
database_cross_reference: PSY:03315
database_cross_reference: RCD:E200.
database_cross_reference: RCD:Eu41z
database_cross_reference: RCDSY:Eu41z
database_cross_reference: SNMI:D9-81000
database_cross_reference: SNOMEDCT_US:191703000
database_cross_reference: SNOMEDCT_US:192405006
database_cross_reference: SNOMEDCT_US:197480006
database_cross_reference: SNOMEDCT_US:65673007

communication disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder that involves specific developmental disorders of speech and language.
PMOID: PMO:00027939
Subclass_of: specific developmental disorder
Synonym: COMMUNICATION DIS
Synonym: COMMUNICATION IMPAIRMENT
Synonym: COMMUNICATIVE DIS
Synonym: Communication Disorder
Synonym: Communication Disorders
Synonym: Communication Disorders [Disease/Finding]
Synonym: Communication disorder
Synonym: Communication disorder (disorder)
Synonym: Communication disorder NOS
Synonym: Communication disorder, NOS
Tree Number: T10.3.5.1.2
database_cross_reference: ALT:NBC
database_cross_reference: AOD:0000023656
database_cross_reference: CHV:0000003209
database_cross_reference: CSP:1579-2995
database_cross_reference: CSP:5000-0013
database_cross_reference: DO:DOID:2033
database_cross_reference: DXP:U000807
database_cross_reference: ICD10CM:F80.9
database_cross_reference: LCH:U001113
database_cross_reference: LCH_NW:sh85029113
database_cross_reference: LNC:LA9950-2
database_cross_reference: LNC:MTHU013385
database_cross_reference: MDR:10010117
database_cross_reference: MDR:10010118
database_cross_reference: MDR:10010119
database_cross_reference: MDR:10061046
database_cross_reference: MEDCIN:298409
database_cross_reference: MEDCIN:312262
database_cross_reference: MEDCIN:314378
database_cross_reference: MEDLINEPLUS:409
database_cross_reference: MSH:D003147
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:307.9
database_cross_reference: NCI:C2958
database_cross_reference: NDFRT:N0000000826
database_cross_reference: PSY:10533
database_cross_reference: RCD:Xa0tn
database_cross_reference: SNMI:D9-18220
database_cross_reference: SNOMEDCT_US:278919001
database_cross_reference: SNOMEDCT_US:74825008

enthesopathy
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032304
Subclass_of: connective tissue disease
Synonym: Enthesopathies
Synonym: Enthesopathy
Synonym: Enthesopathy (disorder)
Synonym: Enthesopathy NOS
Synonym: Enthesopathy NOS (disorder)
Synonym: Enthesopathy [Ambiguous]
Synonym: Enthesopathy [Disease/Finding]
Synonym: Enthesopathy of specified site
Synonym: Enthesopathy of unspecified site
Synonym: Enthesopathy of unspecified site, NOS
Tree Number: T10.8.4.1.19
database_cross_reference: AOD:0000005129
database_cross_reference: CHV:0000024849
database_cross_reference: DO:DOID:204
database_cross_reference: ICD10:M77.9
database_cross_reference: ICD10AM:M77.9
database_cross_reference: ICD10CM:M77.9
database_cross_reference: ICD9CM:726.9
database_cross_reference: ICD9CM:726.90
database_cross_reference: MDR:10014910
database_cross_reference: MDR:10014918
database_cross_reference: MDR:10045864
database_cross_reference: MEDCIN:211117
database_cross_reference: MSH:D000070676
database_cross_reference: MTHICD9:726.90
database_cross_reference: NDFRT:N0000192884
database_cross_reference: RCD:N21z.
database_cross_reference: RCD:Xa0lk
database_cross_reference: SNM:D-3360
database_cross_reference: SNMI:D1-30000
database_cross_reference: SNOMEDCT_US:202890003
database_cross_reference: SNOMEDCT_US:23680005
database_cross_reference: SNOMEDCT_US:278525009

hepatitis B
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.
PMOID: PMO:00029374
Subclass_of: viral infectious disease
Synonym: HBV
Synonym: HEPATITIS B
Synonym: HEPATITIS, SERUM
Synonym: Hep B
Synonym: Hepatitis B
Synonym: Hepatitis B Infection
Synonym: Hepatitis B [Disease/Finding]
Synonym: Hepatitis B infection
Synonym: SH - Serum hepatitis
Synonym: Serum hepatitis
Tree Number: T10.7.2.24
database_cross_reference: AOD:0000004803
database_cross_reference: BI:BI00261
database_cross_reference: CCPSS:1017958
database_cross_reference: CHV:0000006047
database_cross_reference: CHV:0000050592
database_cross_reference: COSTAR:358
database_cross_reference: CSP:1557-4074
database_cross_reference: CSP:1754-6982
database_cross_reference: DO:DOID:2043
database_cross_reference: DXP:NOCODE
database_cross_reference: ICPC2P:D72003
database_cross_reference: LCH:U002172
database_cross_reference: LCH_NW:sh85060295
database_cross_reference: LNC:LA18126-5
database_cross_reference: MDR:10019619
database_cross_reference: MDR:10019731
database_cross_reference: MDR:10040284
database_cross_reference: MDR:10047450
database_cross_reference: MEDCIN:30153
database_cross_reference: MEDLINEPLUS:1687
database_cross_reference: MSH:D006509
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:070.3
database_cross_reference: NCI:C3097
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NICHD:C3097
database_cross_reference: NDFRT:N0000001501
database_cross_reference: RCD:A703.
database_cross_reference: RCD:XE0TY
database_cross_reference: SNM:D-0522
database_cross_reference: SNMI:DE-38010
database_cross_reference: SNOMEDCT_US:154348008
database_cross_reference: SNOMEDCT_US:186625003
database_cross_reference: SNOMEDCT_US:266195001
database_cross_reference: SNOMEDCT_US:66071002

hepatitis D
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.
PMOID: PMO:00029376
Subclass_of: viral infectious disease
Synonym: DELTA INFECT
Synonym: Delta Hepatitis
Synonym: Delta Infection
Synonym: Delta infection
Synonym: HEPATITIS D
Synonym: HEPATITIS DELTA
Synonym: HEPATITIS, ACUTE DELTA
Synonym: Hepatitides, Delta
Synonym: Hepatitis D
Synonym: Hepatitis D Infection
Tree Number: T10.7.2.26
database_cross_reference: AOD:0000004805
database_cross_reference: AOD:0000023163
database_cross_reference: CHV:0000003678
database_cross_reference: CSP:1754-6994
database_cross_reference: DO:DOID:2047
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000809
database_cross_reference: ICPC2P:D72009
database_cross_reference: LCH:U001290
database_cross_reference: LCH_NW:sh86008209
database_cross_reference: MDR:10019762
database_cross_reference: MDR:10019763
database_cross_reference: MEDCIN:30154
database_cross_reference: MSH:D003699
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000913
database_cross_reference: SNOMEDCT_US:424460009
database_cross_reference: SNOMEDCT_US:707341005

reactive cutaneous fibrous lesion
type: Class
subclass of: skin disease
PMOID: PMO:00033963
Subclass_of: skin disease
Synonym: Reactive Cutaneous Fibrous Lesion
Tree Number: T10.8.12.2.43
database_cross_reference: DO:DOID:2053
database_cross_reference: NCI:C27549

post-traumatic stress disorder
type: Class
subclass of: anxiety disorder
definition: An anxiety disorder which results from a traumatic experience that results in psychological trauma.
PMOID: PMO:00028234
Subclass_of: anxiety disorder
Synonym: -- Post Traumatic Stress Disorder
Synonym: Combat Neurosis
Synonym: Disorder;post traumatic stress
Synonym: Neuroses, Post Traumatic
Synonym: Neuroses, Post-Traumatic
Synonym: Neuroses, Posttraumatic
Synonym: Neurosis, traumatic
Synonym: POST TRAUMATIC STRESS DIS
Synonym: POST TRAUMATIC STRESS DISORDER
Synonym: POSTTRAUMATIC STRESS DIS
Tree Number: T10.3.12.5.7
database_cross_reference: AOD:0000006843
database_cross_reference: AOD:0000024063
database_cross_reference: CCPSS:0043002
database_cross_reference: CHV:0000011771
database_cross_reference: COSTAR:U000555
database_cross_reference: CSP:4000-0295
database_cross_reference: DO:DOID:2055
database_cross_reference: DSM-5:309.81
database_cross_reference: DSM-5:F43.10
database_cross_reference: ICD10:F43.1
database_cross_reference: ICD10AM:F43.1
database_cross_reference: ICD10CM:F43.1
database_cross_reference: ICD10CM:F43.10
database_cross_reference: ICD9CM:309.81
database_cross_reference: ICPC2EENG:P82
database_cross_reference: ICPC2P:P02023
database_cross_reference: ICPC2P:P82002
database_cross_reference: LCH:U006189
database_cross_reference: LCH_NW:sh85105424
database_cross_reference: LNC:LA10583-5
database_cross_reference: LNC:LP94805-6
database_cross_reference: MDR:10036316
database_cross_reference: MEDCIN:312094
database_cross_reference: MEDLINEPLUS:367
database_cross_reference: MSH:D013313
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:309.81
database_cross_reference: NCI:C3389
database_cross_reference: NCI_NCI-GLOSS:CDR0000440111
database_cross_reference: NCI_NCI-GLOSS:CDR0000440112
database_cross_reference: NCI_NICHD:C3389
database_cross_reference: NDFRT:N0000002839
database_cross_reference: PDQ:CDR0000042599
database_cross_reference: PSY:39727
database_cross_reference: PSY:54130
database_cross_reference: RCD:X00Sf
database_cross_reference: SNM:D-9242
database_cross_reference: SNMI:D9-81600
database_cross_reference: SNOMEDCT_US:192415000
database_cross_reference: SNOMEDCT_US:47505003

vulvar disease
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system diseaes that is located_in the vulva.
PMOID: PMO:00029810
Subclass_of: female reproductive system disease
Synonym: DISORDER VULVA
Synonym: Disease of vulva
Synonym: Disease of vulva (disorder)
Synonym: Disease of vulva, NOS
Synonym: Disease, Vulvar
Synonym: Diseases, Vulvar
Synonym: Disorder of vulva
Synonym: Disorder of vulva (disorder)
Synonym: Disorder vulva
Synonym: Disorder;vulva
Tree Number: T10.8.1.4.7
database_cross_reference: CHV:0000013092
database_cross_reference: CST:VULVOVAGINAL DIS
database_cross_reference: DO:DOID:2059
database_cross_reference: ICPC2P:X16001
database_cross_reference: LCH_NW:sh85144474
database_cross_reference: MDR:10013287
database_cross_reference: MDR:10047727
database_cross_reference: MDR:10047728
database_cross_reference: MDR:10047754
database_cross_reference: MDR:10047755
database_cross_reference: MEDLINEPLUS:4550
database_cross_reference: MSH:D014845
database_cross_reference: NCI:C27631
database_cross_reference: NDFRT:N0000003145
database_cross_reference: RCD:X4082
database_cross_reference: SNMI:D7-70060
database_cross_reference: SNOMEDCT_US:5089007

intestinal perforation
type: Class
subclass of: intestinal disease
PMOID: PMO:00033590
Subclass_of: intestinal disease
Synonym: BOWEL PERFORATION
Synonym: Bowel Perforation
Synonym: Bowel perforation
Synonym: INTESTINAL PERFORATION
Synonym: INTESTINE, PERFORATION
Synonym: Intestinal Perforation
Synonym: Intestinal Perforation [Disease/Finding]
Synonym: Intestinal Perforations
Synonym: Intestinal perforation
Synonym: Intestinal perforation NOS
Tree Number: T10.8.11.8.12
database_cross_reference: CCPSS:1017389
database_cross_reference: CHV:0000006860
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:INTEST PER
database_cross_reference: DO:DOID:2074
database_cross_reference: DXP:U000945
database_cross_reference: DXP:U002141
database_cross_reference: HPO:HP:0031368
database_cross_reference: ICD9CM:569.83
database_cross_reference: MDR:10006056
database_cross_reference: MDR:10022694
database_cross_reference: MDR:10022696
database_cross_reference: MDR:10034222
database_cross_reference: MDR:10034385
database_cross_reference: MDR:10034406
database_cross_reference: MDR:10034413
database_cross_reference: MDR:10034421
database_cross_reference: MEDCIN:337697
database_cross_reference: MSH:D007416
database_cross_reference: NCI:C39611
database_cross_reference: NCI_FDA:2668
database_cross_reference: NCI_NICHD:C39611
database_cross_reference: NDFRT:N0000001703
database_cross_reference: OMIM:MTHU033352
database_cross_reference: RCD:J57yB
database_cross_reference: SNMI:D5-42600
database_cross_reference: SNOMEDCT_US:56905009

coccidiosis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that occurs in the intestinal tract of animals and humans caused by Coccidia protozoa. Immunocompromised persons are at greater risk of developing the infection.
PMOID: PMO:00029687
Subclass_of: parasitic protozoa infectious disease
Synonym: COCCIDIOSIS
Synonym: Coccidioses
Synonym: Coccidiosis
Synonym: Coccidiosis (diagnosis)
Synonym: Coccidiosis (disorder)
Synonym: Coccidiosis [Disease/Finding]
Synonym: Coccidiosis infection
Synonym: Coccidiosis, NOS
Synonym: protozoal disease coccidiosis
Tree Number: T10.7.4.2.7
database_cross_reference: CHV:0000003106
database_cross_reference: DO:DOID:2113
database_cross_reference: DXP:U000373
database_cross_reference: LCH:U001072
database_cross_reference: LCH_NW:sh85027570
database_cross_reference: MDR:10009827
database_cross_reference: MEDCIN:356375
database_cross_reference: MSH:D003048
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34493
database_cross_reference: NDFRT:N0000000801
database_cross_reference: RCD:XE0Qi
database_cross_reference: SNM:D-0667
database_cross_reference: SNMI:DE-50110
database_cross_reference: SNOMEDCT_US:186125004
database_cross_reference: SNOMEDCT_US:62005008

B cell deficiency
type: Class
subclass of: primary immunodeficiency disease
definition: A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly.
PMOID: PMO:00032649
Subclass_of: primary immunodeficiency disease
Synonym: B cell (antibody) deficiencies
Synonym: Immunoglobulin heavy chain deficiency
Synonym: Other select.immunoglob.defic.
Synonym: Other selective immunoglobulin deficiencies
Synonym: Other selective immunoglobulin deficiency
Synonym: Other selective immunoglobulin deficiency (finding)
Synonym: Selective ig defic NEC
Synonym: immunoglobulin heavy chain deletion
Tree Number: T10.8.6.1.4
database_cross_reference: DO:DOID:2115
database_cross_reference: ICD9CM:279.03
database_cross_reference: MDR:10032462
database_cross_reference: RCD:C3904
database_cross_reference: SNOMEDCT_US:190982008

focal dermal hypoplasia
type: Class
subclass of: X-linked disease
PMOID: PMO:00028730
Subclass_of: X-linked disease
Synonym: DHOF
Synonym: Dermal Hypoplasia, Focal
Synonym: Dermal Hypoplasias, Focal
Synonym: FDH
Synonym: FDH - Focal dermal hypoplasia
Synonym: FOCAL DERMAL HYPOPLASIA
Synonym: FOCAL DERMAL HYPOPLASIA SYNDROME
Synonym: FODH
Synonym: FODH - Focal dermal hypoplasia
Synonym: Focal Dermal Hypoplasia
Tree Number: T10.5.3.4.10
database_cross_reference: CHV:0000005143
database_cross_reference: CSP:0726-8244
database_cross_reference: DO:DOID:2120
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000674
database_cross_reference: JABL:322
database_cross_reference: MSH:D005489
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84715
database_cross_reference: NDFRT:N0000001264
database_cross_reference: OMIM:300651
database_cross_reference: OMIM:305600
database_cross_reference: RCD:PH334
database_cross_reference: RCD:X50Kk
database_cross_reference: SNM:D-5408
database_cross_reference: SNMI:D4-01054
database_cross_reference: SNOMEDCT_US:205573006
database_cross_reference: SNOMEDCT_US:2298005

tularemia
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that has material basis in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues.
PMOID: PMO:00029489
Subclass_of: primary bacterial infectious disease
Synonym: Enteric tularemia
Synonym: Other specified tularaemia
Synonym: Other specified tularaemia -RETIRED-
Synonym: Other specified tularaemia NOS
Synonym: Other specified tularemia
Synonym: Other specified tularemia (disorder)
Synonym: Other specified tularemia -RETIRED-
Synonym: Other specified tularemia NOS
Synonym: Other specified tularemia NOS (disorder)
Synonym: Tularemia NEC
Tree Number: T10.7.3.1.8
database_cross_reference: DO:DOID:14239
database_cross_reference: DO:DOID:2123
database_cross_reference: ICD9CM:021.8
database_cross_reference: MDR:10032923
database_cross_reference: RCD:A21y.
database_cross_reference: RCD:A21yz
database_cross_reference: RCDAE:A21y.
database_cross_reference: RCDAE:A21yz
database_cross_reference: SNMI:DE-15080
database_cross_reference: SNOMEDCT_US:111834003
database_cross_reference: SNOMEDCT_US:186298002
database_cross_reference: SNOMEDCT_US:186299005

coagulation protein disease
type: Class
subclass of: blood coagulation disease
PMOID: PMO:00033292
Subclass_of: blood coagulation disease
Synonym: BLOOD COAG FACTOR DEFIC
Synonym: Blood Coagulation Factor Deficiencies
Synonym: COAG PROTEIN DIS
Synonym: Coagulation Protein Disorder
Synonym: Coagulation Protein Disorders
Synonym: Coagulation Protein Disorders [Disease/Finding]
Synonym: Coagulation Proteins Disorder
Synonym: Coagulation Proteins Disorders
Synonym: Disorder, Coagulation Protein
Synonym: Disorder, Coagulation Proteins
Tree Number: T10.8.10.1.2
database_cross_reference: DO:DOID:2212
database_cross_reference: MSH:D020147
database_cross_reference: NDFRT:N0000004004

hemorrhagic disease
type: Class
subclass of: blood coagulation disease
PMOID: PMO:00033299
Subclass_of: blood coagulation disease
Synonym: Diatheses, Hemorrhagic
Synonym: Diathesis, Hemorrhagic
Synonym: Disorder, Hemorrhagic
Synonym: Disorders, Hemorrhagic
Synonym: HEMORRHAGIC DIS
Synonym: HEMORRHAGIC DISORDER
Synonym: Haemorrhag condition, unsp
Synonym: Haemorrhagic condition NOS
Synonym: Haemorrhagic condition, unspecified
Synonym: Haemorrhagic diathesis
Tree Number: T10.8.10.1.5
database_cross_reference: AOD:0000022966
database_cross_reference: CHV:0000006010
database_cross_reference: CSP:0427-4811
database_cross_reference: CST:PATHHEM
database_cross_reference: DO:DOID:2213
database_cross_reference: HPO:HP:0001928
database_cross_reference: ICD10:D69.9
database_cross_reference: ICD10AM:D69.9
database_cross_reference: ICD10AMAE:D69.9
database_cross_reference: ICD10CM:D69.9
database_cross_reference: ICD9CM:287.9
database_cross_reference: LCH:U005629
database_cross_reference: LCH_NW:sh85060228
database_cross_reference: MDR:10019009
database_cross_reference: MDR:10045897
database_cross_reference: MDR:10045907
database_cross_reference: MDR:10055279
database_cross_reference: MDR:10062713
database_cross_reference: MDR:10062720
database_cross_reference: MEDCIN:99903
database_cross_reference: MSH:D006474
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:287.9
database_cross_reference: NDFRT:N0000001485
database_cross_reference: RCD:D31z.
database_cross_reference: RCD:Dyu34
database_cross_reference: RCDAE:D31z.
database_cross_reference: RCDAE:Dyu34
database_cross_reference: RCDSY:Dyu34
database_cross_reference: SNOMEDCT_US:191327000
database_cross_reference: SNOMEDCT_US:191331006
database_cross_reference: SNOMEDCT_US:191437009
database_cross_reference: SNOMEDCT_US:268884000

inherited blood coagulation disease
type: Class
subclass of: blood coagulation disease
PMOID: PMO:00033260
Subclass_of: blood coagulation disease
Synonym: BLOOD COAG DIS INHERITED
Synonym: Blood Coagulation Disorders, Inherited
Synonym: Blood Coagulation Disorders, Inherited [Disease/Finding]
Synonym: COAG DIS INHERITED
Synonym: Coagulation Disorder, Hereditary
Synonym: Coagulation Disorder, Inherited
Synonym: Coagulation Disorders, Hereditary
Synonym: Coagulation Disorders, Inherited
Synonym: Coagulation disorders congenital
Synonym: HEREDITARY BLOOD COAG DIS
Tree Number: T10.8.10.1.1
database_cross_reference: DO:DOID:2214
database_cross_reference: MDR:10009735
database_cross_reference: MSH:D025861
database_cross_reference: NDFRT:N0000010965

factor XI deficiency
type: Class
subclass of: autosomal genetic disease
PMOID: PMO:00028393
Subclass_of: autosomal genetic disease
Synonym: Cong factor xi disorder
Synonym: Congenital factor XI deficiency
Synonym: Congenital factor XI deficiency disease
Synonym: DEFIC FACTOR XI
Synonym: Deficiencies, Factor XI
Synonym: Deficiency, Factor XI
Synonym: F11 DEFICIENCY
Synonym: FACTOR XI DEFIC
Synonym: FACTOR XI DEFICIENCY
Synonym: Factor XI Deficiencies
Tree Number: T10.5.3.2.2
database_cross_reference: CHV:0000004866
database_cross_reference: DO:DOID:2229
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000625
database_cross_reference: HPO:HP:0001929
database_cross_reference: ICD10:D68.1
database_cross_reference: ICD10AM:D68.1
database_cross_reference: ICD10CM:D68.1
database_cross_reference: ICD9CM:286.2
database_cross_reference: MDR:10010469
database_cross_reference: MDR:10016082
database_cross_reference: MDR:10018940
database_cross_reference: MDR:10060615
database_cross_reference: MEDCIN:30317
database_cross_reference: MSH:D005173
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:286.2
database_cross_reference: NCI:C84705
database_cross_reference: NCI_NICHD:C84705
database_cross_reference: NDFRT:N0000001202
database_cross_reference: OMIM:264900
database_cross_reference: OMIM:612416
database_cross_reference: OMIM:MTHU005159
database_cross_reference: RCD:D302.
database_cross_reference: RCDAE:D302.
database_cross_reference: SNM:D-4435
database_cross_reference: SNMI:DC-63240
database_cross_reference: SNOMEDCT_US:49762007

factor XII deficiency
type: Class
subclass of: autosomal genetic disease
PMOID: PMO:00028392
Subclass_of: autosomal genetic disease
Synonym: Coagulation Factor 12 Deficiency
Synonym: DEFIC FACTOR XII
Synonym: Deficiencies, Factor 12
Synonym: Deficiencies, Factor XII
Synonym: Deficiency, Factor 12
Synonym: Deficiency, Factor XII
Synonym: Deficiency, Hageman
Synonym: Deficiency, Hageman Factor
Synonym: Deficiency, factor XII
Synonym: F12 DEFICIENCY
Tree Number: T10.5.3.2.1
database_cross_reference: CHV:0000004868
database_cross_reference: DO:DOID:2231
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000626
database_cross_reference: HPO:HP:0004841
database_cross_reference: MDR:10051806
database_cross_reference: MEDCIN:30318
database_cross_reference: MSH:D005175
database_cross_reference: MTHICD9:286.3
database_cross_reference: NDFRT:N0000001203
database_cross_reference: OMIM:234000
database_cross_reference: OMIM:610619
database_cross_reference: RCD:D3035
database_cross_reference: SNMI:DC-63300
database_cross_reference: SNOMEDCT_US:46981006

syndrome
type: Class
subclass of: Disease
definition: A disease characterized by a group of signs and symptoms that occur together and characterize a particular abnormality.
PMOID: PMO:00025115
Subclass_of: Disease
Synonym: Cluster, Symptom
Synonym: Clusters, Symptom
Synonym: Symptom Cluster
Synonym: Symptom Clusters
Synonym: Syndrome
Synonym: Syndrome [Disease/Finding]
Synonym: Syndrome, NOS
Synonym: Syndromes
Synonym: syndromes
Tree Number: T10.1
database_cross_reference: AOD:0000001751
database_cross_reference: CHV:0000011977
database_cross_reference: CSP:0944-7801
database_cross_reference: DO:DOID:225
database_cross_reference: LCH:U004560
database_cross_reference: LCH_NW:sh85131629
database_cross_reference: MSH:D013577
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C28193
database_cross_reference: NCI_NCI-GLOSS:CDR0000045090
database_cross_reference: NCI_NICHD:C28193
database_cross_reference: NDFRT:N0000002875
database_cross_reference: PSY:51170
database_cross_reference: SNMI:DF-00000
database_cross_reference: SNOMEDCT_US:64572001

vulvovaginitis
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is characterized by inflammation of the vagina and vulva.
PMOID: PMO:00029837
Subclass_of: female reproductive system disease
Synonym: VULVOVAGINITIS
Synonym: Vulvo-vaginitis
Synonym: Vulvovaginitides
Synonym: Vulvovaginitis
Synonym: Vulvovaginitis (disorder)
Synonym: Vulvovaginitis NOS
Synonym: Vulvovaginitis [Disease/Finding]
Synonym: Vulvovaginitis unspecified
Synonym: Vulvovaginitis unspecified (disorder)
Synonym: Vulvovaginitis, NOS
Tree Number: T10.8.1.4.14
database_cross_reference: CCPSS:0004019
database_cross_reference: CHV:0000013096
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:VULVOVAGINITIS
database_cross_reference: DO:DOID:2273
database_cross_reference: DXP:U004450
database_cross_reference: ICD10CM:N76.0
database_cross_reference: LCH:U004999
database_cross_reference: LCH_NW:sh85144476
database_cross_reference: MDR:10047794
database_cross_reference: MDR:10047798
database_cross_reference: MEDCIN:38326
database_cross_reference: MSH:D014848
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:616.10
database_cross_reference: NCI:C35131
database_cross_reference: NCI_NICHD:C35131
database_cross_reference: NDFRT:N0000003148
database_cross_reference: OMIM:MTHU026353
database_cross_reference: RCD:K4212
database_cross_reference: RCD:X407m
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D7-71620
database_cross_reference: SNOMEDCT_US:155981006
database_cross_reference: SNOMEDCT_US:198215008
database_cross_reference: SNOMEDCT_US:266655004
database_cross_reference: SNOMEDCT_US:53277000

pharyngitis
type: Class
subclass of: upper respiratory tract disease
PMOID: PMO:00032501
Subclass_of: upper respiratory tract disease
Synonym: Inflamed throat
Synonym: Inflamed throat (disorder)
Synonym: Inflamed throat (finding)
Synonym: Inflamed;throat
Synonym: Inflammation;throat
Synonym: PHARYNGEAL INFLAMMATION
Synonym: PHARYNGITIS
Synonym: Pharyngeal inflammation
Synonym: Pharyngitides
Synonym: Pharyngitis
Tree Number: T10.8.5.2.11
database_cross_reference: BI:BI00661
database_cross_reference: CCPSS:1003427
database_cross_reference: CHV:0000009584
database_cross_reference: CHV:0000036048
database_cross_reference: CHV:0000049691
database_cross_reference: CHV:0000058191
database_cross_reference: COSTAR:581
database_cross_reference: CSP:2139-2226
database_cross_reference: CST:PHARYNGITIS
database_cross_reference: DRUGBANK:DB03255
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U003121
database_cross_reference: HPO:HP:0025439
database_cross_reference: ICPC2P:R21009
database_cross_reference: ICPC2P:R21010
database_cross_reference: LCH:U003602
database_cross_reference: LCH_NW:sh85100626
database_cross_reference: MDR:10034835
database_cross_reference: MDR:10034838
database_cross_reference: MDR:10065716
database_cross_reference: MEDCIN:31284
database_cross_reference: MEDCIN:6863
database_cross_reference: MEDLINEPLUS:4748
database_cross_reference: MSH:D010612
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:462
database_cross_reference: NCI:C26851
database_cross_reference: NCI_CTCAE:E11525
database_cross_reference: NCI_FDA:2367
database_cross_reference: NCI_NICHD:C26851
database_cross_reference: NDFRT:N0000002387
database_cross_reference: OMIM:MTHU007438
database_cross_reference: RCD:2DC3.
database_cross_reference: RCD:X00mG
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D2-03005
database_cross_reference: SNOMEDCT_US:141458004
database_cross_reference: SNOMEDCT_US:164261009
database_cross_reference: SNOMEDCT_US:37616004
database_cross_reference: SNOMEDCT_US:405737000
database_cross_reference: SNOMEDCT_VET:405737000

gonadal disease
type: Class
subclass of: endocrine system disease
definition: An endocrine system disease that is located_in the gonads.
PMOID: PMO:00033113
Subclass_of: endocrine system disease
Synonym: Disease of gonad
Synonym: Disorder of Gonads
Synonym: Disorder, Gonadal
Synonym: Disorders, Gonadal
Synonym: GONAD DISORDER
Synonym: GONADAL DIS
Synonym: GONADAL DYSFUNCTION
Synonym: Gonadal Disorder
Synonym: Gonadal Disorders
Synonym: Gonadal Disorders [Disease/Finding]
Tree Number: T10.8.8.2
database_cross_reference: CHV:0000005651
database_cross_reference: COSTAR:U000330
database_cross_reference: CSP:2587-5836
database_cross_reference: DO:DOID:2277
database_cross_reference: DXP:U001718
database_cross_reference: LCH_NW:sh97002795
database_cross_reference: MSH:D006058
database_cross_reference: NCI:C26786
database_cross_reference: NCI_NICHD:C26786
database_cross_reference: NDFRT:N0000001376
database_cross_reference: SNM:D-2560

female reproductive system disease
type: Class
subclass of: reproductive system disease
definition: A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.
PMOID: PMO:00029778
Subclass_of: reproductive system disease
Synonym: 7-70 DISEASES OF THE FEMALE GENITAL ORGANS: GENERAL TERMS
Synonym: DISEASES OF THE FEMALE GENITAL ORGANS
Synonym: DISEASES OF THE FEMALE GENITAL ORGANS: GENERAL TERMS
Synonym: Disease of female genital organ
Synonym: Disease of female genital organ (disorder)
Synonym: Disease of female genital organ [Ambiguous]
Synonym: Disease of female genital organs, NOS
Synonym: Disease of female genital system
Synonym: Disease;genital;F
Synonym: Diseases, Female Genital
Tree Number: T10.8.1.4
database_cross_reference: CHV:0000005443
database_cross_reference: CST:GYN
database_cross_reference: CST:UG/FG
database_cross_reference: DO:DOID:229
database_cross_reference: ICD9CM:629.9
database_cross_reference: ICPC2P:X99026
database_cross_reference: MDR:10018144
database_cross_reference: MDR:10045787
database_cross_reference: MDR:10061176
database_cross_reference: MEDCIN:338595
database_cross_reference: MEDCIN:38669
database_cross_reference: MSH:D005831
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001323
database_cross_reference: PSY:22040
database_cross_reference: RCD:K5z..
database_cross_reference: RCD:XaCOl
database_cross_reference: SNMI:D7-70000
database_cross_reference: SNOMEDCT_US:156032001
database_cross_reference: SNOMEDCT_US:156066005
database_cross_reference: SNOMEDCT_US:198486002
database_cross_reference: SNOMEDCT_US:244938009
database_cross_reference: SNOMEDCT_US:266680004
database_cross_reference: SNOMEDCT_US:310789003
database_cross_reference: SNOMEDCT_US:38233001

leptospirosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.
PMOID: PMO:00029531
Subclass_of: primary bacterial infectious disease
Synonym: Disease, Weil
Synonym: Disease, Weil's
Synonym: FIEDLER DISEASE
Synonym: Fort Bragg fever
Synonym: Haemorrhagic leptospiral jaundice
Synonym: Haemorrhagic leptospirosis with jaundice
Synonym: Haemorrhagic spirochaetal jaundice
Synonym: Hemorrhagic leptospiral jaundice
Synonym: Hemorrhagic leptospiral or spirochetal jaundice
Synonym: Hemorrhagic leptospirosis with jaundice
Tree Number: T10.7.3.1.26
database_cross_reference: CHV:0000013134
database_cross_reference: CSP:0368-3335
database_cross_reference: DO:DOID:2297
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001041
database_cross_reference: ICD10:A27.0
database_cross_reference: ICD10AM:A27.0
database_cross_reference: ICD10CM:A27.0
database_cross_reference: ICD9CM:100.0
database_cross_reference: LCH:U005015
database_cross_reference: LCH_NW:sh85145979
database_cross_reference: MDR:10019014
database_cross_reference: MDR:10024239
database_cross_reference: MDR:10024240
database_cross_reference: MDR:10047903
database_cross_reference: MDR:10055283
database_cross_reference: MEDCIN:31068
database_cross_reference: MEDCIN:359957
database_cross_reference: MSH:D014895
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:100.0
database_cross_reference: NDFRT:N0000003157
database_cross_reference: RCD:AA0..
database_cross_reference: RCD:XE2uK
database_cross_reference: RCDAE:AA0..
database_cross_reference: SNM:D-0197
database_cross_reference: SNMI:DE-12420
database_cross_reference: SNOMEDCT_US:154391003
database_cross_reference: SNOMEDCT_US:186954006
database_cross_reference: SNOMEDCT_US:266213004
database_cross_reference: SNOMEDCT_US:398067003
database_cross_reference: SNOMEDCT_US:398222003
database_cross_reference: SNOMEDCT_US:69092001

stereotypic movement disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder that is characterized by repeated, rhythmic, purposeless movements or activities such as head banging, nail biting, or body rocking.
PMOID: PMO:00028116
Subclass_of: specific developmental disorder
Synonym: MOVEMENT DIS STEREOTYPIC
Synonym: Movement Disorder, Stereotypic
Synonym: Repetitive movements
Synonym: STEREOTYPIC MOVEMENT DIS
Synonym: Stereotyped behavior
Synonym: Stereotyped movement
Synonym: Stereotyped movement disorder
Synonym: Stereotyped movement disorders
Synonym: Stereotyped repetitive movements
Synonym: Stereotyped, repetitive behaviour
Tree Number: T10.3.5.1.11
database_cross_reference: AOD:0000006730
database_cross_reference: CHV:0000011720
database_cross_reference: DO:DOID:2303
database_cross_reference: DSM-5:307.3
database_cross_reference: DSM-5:F98.4
database_cross_reference: HPO:HP:0000733
database_cross_reference: ICD10:F98.4
database_cross_reference: ICD10AM:F98.4
database_cross_reference: ICD10CM:F98.4
database_cross_reference: ICD9CM:307.3
database_cross_reference: LCH_NW:sh2005001004
database_cross_reference: MDR:10042005
database_cross_reference: MDR:10042008
database_cross_reference: MDR:10042009
database_cross_reference: MEDCIN:32667
database_cross_reference: MSH:D019956
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:307.3
database_cross_reference: NDFRT:N0000003969
database_cross_reference: OMIM:MTHU008369
database_cross_reference: RCD:Eu9y4
database_cross_reference: SNM:F-91200
database_cross_reference: SNMI:D9-10140
database_cross_reference: SNMI:F-93443
database_cross_reference: SNOMEDCT_US:5507002

nocardiosis
type: Class
subclass of: opportunistic bacterial infectious disease
definition: An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.
PMOID: PMO:00029614
Subclass_of: opportunistic bacterial infectious disease
Synonym: INFECT NOCARDIA
Synonym: Infection, Nocardia
Synonym: Infections, Nocardia
Synonym: NOCARDIA INFECT
Synonym: NOCARDIOSIS
Synonym: Nocardia Infection
Synonym: Nocardia Infections
Synonym: Nocardia Infections [Disease/Finding]
Synonym: Nocardia infection
Synonym: Nocardia infections
Tree Number: T10.7.3.5.1
database_cross_reference: CHV:0000008752
database_cross_reference: CSP:0368-2462
database_cross_reference: DO:DOID:2312
database_cross_reference: DXP:U001302
database_cross_reference: DXP:U002827
database_cross_reference: ICD10:A43
database_cross_reference: ICD10:A43.9
database_cross_reference: ICD10AM:A43
database_cross_reference: ICD10AM:A43.9
database_cross_reference: ICD10CM:A43
database_cross_reference: ICD10CM:A43.9
database_cross_reference: MDR:10029443
database_cross_reference: MDR:10029444
database_cross_reference: MDR:10064083
database_cross_reference: MEDCIN:31016
database_cross_reference: MSH:D009617
database_cross_reference: MTHICD9:039.9
database_cross_reference: NDFRT:N0000002188
database_cross_reference: RCD:A39z1
database_cross_reference: RCD:Ayu3N
database_cross_reference: RCD:Xa86S
database_cross_reference: RCDSY:Ayu3N
database_cross_reference: SNM:D-0153
database_cross_reference: SNMI:DE-11060
database_cross_reference: SNOMEDCT_US:186404005
database_cross_reference: SNOMEDCT_US:187337003
database_cross_reference: SNOMEDCT_US:29227009
database_cross_reference: SNOMEDCT_VET:29227009

gastroenteritis
type: Class
subclass of: gastrointestinal system disease
definition: A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.
PMOID: PMO:00033520
Subclass_of: gastrointestinal system disease
Synonym: Already mapped above AAHA ID #: 858
Synonym: GASTROENTERITIS
Synonym: GE - Gastroenteritis
Synonym: Gastroenteritides
Synonym: Gastroenteritis
Synonym: Gastroenteritis (disorder)
Synonym: Gastroenteritis NOS
Synonym: Gastroenteritis [Disease/Finding]
Synonym: Gastroenteritis, NOS
Synonym: Gastrointestinal tract inflamed
Tree Number: T10.8.11.5
database_cross_reference: CCPSS:1005421
database_cross_reference: CHV:0000005379
database_cross_reference: COSTAR:323
database_cross_reference: CSP:1248-5821
database_cross_reference: CST:GASTROENTERITIS
database_cross_reference: DO:DOID:2326
database_cross_reference: DXP:U001647
database_cross_reference: ICD10CM:K52.9
database_cross_reference: ICPC2P:D73008
database_cross_reference: LCH:U001926
database_cross_reference: LCH_NW:sh85053475
database_cross_reference: MDR:10017888
database_cross_reference: MDR:10017907
database_cross_reference: MEDCIN:31119
database_cross_reference: MEDLINEPLUS:3056
database_cross_reference: MSH:D005759
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:009.0
database_cross_reference: NCI:C34632
database_cross_reference: NCI_NCI-GLOSS:CDR0000666216
database_cross_reference: NCI_NICHD:C34632
database_cross_reference: NDFRT:N0000001317
database_cross_reference: OMIM:MTHU035020
database_cross_reference: RCD:X30BN
database_cross_reference: SNMI:D5-41706
database_cross_reference: SNOMEDCT_US:154278002
database_cross_reference: SNOMEDCT_US:197010007
database_cross_reference: SNOMEDCT_US:25374005
database_cross_reference: SNOMEDCT_US:266179001
database_cross_reference: SNOMEDCT_VET:25374005

polyclonal hypergammaglobulinemia
type: Class
subclass of: plasma protein metabolism disease
PMOID: PMO:00029046
Subclass_of: plasma protein metabolism disease
Synonym: Polyclon hypergammaglobu
Synonym: Polyclonal Hypergammaglobulinemia
Synonym: Polyclonal hypergammaglob. NOS
Synonym: Polyclonal hypergammaglobulin.
Synonym: Polyclonal hypergammaglobulinaemia
Synonym: Polyclonal hypergammaglobulinaemia NOS
Synonym: Polyclonal hypergammaglobulinemia
Synonym: Polyclonal hypergammaglobulinemia (disorder)
Synonym: Polyclonal hypergammaglobulinemia NOS
Synonym: Polyclonal hypergammaglobulinemia NOS (disorder)
Tree Number: T10.6.2.7.4
database_cross_reference: AOD:0000005752
database_cross_reference: DO:DOID:2344
database_cross_reference: ICD10:D89.0
database_cross_reference: ICD10AM:D89.0
database_cross_reference: ICD10AMAE:D89.0
database_cross_reference: ICD10CM:D89.0
database_cross_reference: ICD9CM:273.0
database_cross_reference: MDR:10036041
database_cross_reference: MDR:10036042
database_cross_reference: MEDCIN:333672
database_cross_reference: NCI:C35885
database_cross_reference: RCD:C330.
database_cross_reference: RCD:C330z
database_cross_reference: RCDAE:C330.
database_cross_reference: RCDAE:C330z
database_cross_reference: SNOMEDCT_US:190808009
database_cross_reference: SNOMEDCT_US:190811005

plasma protein metabolism disease
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that involves plasma protein metabolism malfunction.
PMOID: PMO:00029042
Subclass_of: inherited metabolic disorder
Synonym: Dis plas protein met NEC
Synonym: Other disorder of plasma protein metabolism
Synonym: Other disorder of plasma protein metabolism (disorder)
Synonym: Other disorders of plasma protein metabolism
Synonym: Other disorders of plasma protein metabolism NOS
Synonym: Other disorders of plasma protein metabolism NOS (disorder)
Synonym: Other plasma prot met dis NOS
Synonym: Other plasma prot.metab.disord
Tree Number: T10.6.2.7
database_cross_reference: DO:DOID:2345
database_cross_reference: ICD9CM:273.8
database_cross_reference: MDR:10031996
database_cross_reference: RCD:C33y.
database_cross_reference: RCD:C33yz
database_cross_reference: SNOMEDCT_US:190822009
database_cross_reference: SNOMEDCT_US:190825006

monoclonal paraproteinemia
type: Class
subclass of: plasma protein metabolism disease
PMOID: PMO:00029043
Subclass_of: plasma protein metabolism disease
Synonym: Monoclon paraproteinemia
Synonym: Monoclonal Paraproteinemia
Synonym: Monoclonal paraproteinaemia
Synonym: Monoclonal paraproteinemia
Synonym: Monoclonal paraproteinemia (disorder)
Synonym: paraproteinemia monoclonal
Tree Number: T10.6.2.7.1
database_cross_reference: CHV:0000008235
database_cross_reference: DO:DOID:2346
database_cross_reference: ICD9CM:273.1
database_cross_reference: MDR:10027866
database_cross_reference: MDR:10027867
database_cross_reference: NCI:C35878
database_cross_reference: RCD:XE11b
database_cross_reference: RCDAE:XE11b
database_cross_reference: SNOMEDCT_US:190812003
database_cross_reference: SNOMEDCT_US:267440005

iron metabolism disease
type: Class
subclass of: mineral metabolism disease
definition: A hemochromatosis characterized by autosomal recessive inheritance of early onset of severe iron loading with symptoms including; hypogonadotropic hypogonadism, cardiomyopathy, arthropathy, and liver fibrosis or cirrhosis.
PMOID: PMO:00028924
Subclass_of: mineral metabolism disease
Synonym: 6-31 DISORDERS OF IRON METABOLISM
Synonym: DISORDERS OF IRON METABOLISM
Synonym: Disorder of iron metabol. NOS
Synonym: Disorder of iron metabolism
Synonym: Disorder of iron metabolism (disorder)
Synonym: Disorder of iron metabolism NOS
Synonym: Disorder of iron metabolism NOS (disorder)
Synonym: Disorder of iron metabolism, NOS
Synonym: Disorder of iron metabolism, unspecified
Synonym: Disorder, Iron Metabolism
Tree Number: T10.6.1.5.2
database_cross_reference: AOD:0000005757
database_cross_reference: AOD:0000023442
database_cross_reference: CHV:0000004026
database_cross_reference: CSP:1630-2859
database_cross_reference: CST:MAN/ION/FE
database_cross_reference: DO:DOID:0111034
database_cross_reference: DO:DOID:2351
database_cross_reference: ICD10:E83.1
database_cross_reference: ICD10AM:E83.1
database_cross_reference: ICD10CM:E83.1
database_cross_reference: ICD10CM:E83.10
database_cross_reference: ICD9CM:275.0
database_cross_reference: LCH_NW:sh85068203
database_cross_reference: MDR:10013314
database_cross_reference: MDR:10022983
database_cross_reference: MEDCIN:315541
database_cross_reference: MSH:D019189
database_cross_reference: NDFRT:N0000003901
database_cross_reference: RCD:C350.
database_cross_reference: RCD:C350z
database_cross_reference: SNMI:D6-31000
database_cross_reference: SNOMEDCT_US:154751003
database_cross_reference: SNOMEDCT_US:190851008
database_cross_reference: SNOMEDCT_US:267504005
database_cross_reference: SNOMEDCT_US:30913008

hemochromatosis
type: Class
subclass of: metal metabolism disorder
definition: A metal metabolism disorder characterized by the accumulation of iron in various organs of the body.
PMOID: PMO:00029019
Subclass_of: metal metabolism disorder
Synonym: Bronze Diabetes
Synonym: Bronze diabetes
Synonym: Bronze diabetes (disorder)
Synonym: Bronzed Cirrhoses
Synonym: Bronzed Cirrhosis
Synonym: Bronzed diabetes
Synonym: Cirrhoses, Bronzed
Synonym: Cirrhoses, Pigmentary
Synonym: Cirrhosis, Bronzed
Synonym: Cirrhosis, Pigmentary
Tree Number: T10.6.2.4.5
database_cross_reference: AOD:0000005758
database_cross_reference: AOD:0000005759
database_cross_reference: AOD:0000023445
database_cross_reference: CCPSS:1006065
database_cross_reference: CHV:0000005975
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1630-3927
database_cross_reference: CSP:1849-4292
database_cross_reference: CST:HEMOCHROMATO
database_cross_reference: DO:DOID:2352
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:E83.11
database_cross_reference: ICD10CM:E83.110
database_cross_reference: ICD10CM:E83.119
database_cross_reference: ICPC2P:T99035
database_cross_reference: LCH:U002143
database_cross_reference: LCH_NW:sh85060186
database_cross_reference: MDR:10006489
database_cross_reference: MDR:10018872
database_cross_reference: MDR:10019478
database_cross_reference: MEDCIN:30573
database_cross_reference: MEDCIN:314750
database_cross_reference: MEDLINEPLUS:1220
database_cross_reference: MSH:D006432
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:275.01
database_cross_reference: MTHICD9:275.03
database_cross_reference: NCI:C84481
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000446804
database_cross_reference: NCI_NICHD:C84481
database_cross_reference: NDFRT:N0000001469
database_cross_reference: RCD:C3500
database_cross_reference: RCD:X307o
database_cross_reference: SNM:D-1190
database_cross_reference: SNM:D-1192
database_cross_reference: SNMI:D6-31210
database_cross_reference: SNOMEDCT_US:154751003
database_cross_reference: SNOMEDCT_US:267504005
database_cross_reference: SNOMEDCT_US:399144008
database_cross_reference: SNOMEDCT_US:399187006
database_cross_reference: SNOMEDCT_US:86781004
database_cross_reference: SNOMEDCT_VET:399187006

anemia
type: Class
subclass of: hematopoietic system disease
definition: A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.
PMOID: PMO:00033325
Subclass_of: hematopoietic system disease
Synonym: ANAEMIA
Synonym: ANEMIA
Synonym: Anaemia
Synonym: Anaemia (disorder)
Synonym: Anaemia NOS
Synonym: Anaemia unspecified
Synonym: Anaemia unspecified (disorder)
Synonym: Anaemia, NOS
Synonym: Anaemia, unspecified
Synonym: Anemia
Tree Number: T10.8.10.4
database_cross_reference: AOD:0000005870
database_cross_reference: AOD:0000023514
database_cross_reference: BI:BI00026
database_cross_reference: CCPSS:1017210
database_cross_reference: CHV:0000001118
database_cross_reference: COSTAR:051
database_cross_reference: CSP:0427-0313
database_cross_reference: CST:ANEMIA
database_cross_reference: DO:DOID:2355
database_cross_reference: DXP:U000172
database_cross_reference: HPO:HP:0001903
database_cross_reference: ICD10:D64.9
database_cross_reference: ICD10AM:D64.9
database_cross_reference: ICD10AMAE:D64.9
database_cross_reference: ICD10CM:D64.9
database_cross_reference: ICD9CM:285.9
database_cross_reference: ICPC2P:B82005
database_cross_reference: LCH:U000235
database_cross_reference: LCH_NW:sh85004940
database_cross_reference: LNC:LA18969-8
database_cross_reference: LNC:MTHU020823
database_cross_reference: MDR:10002034
database_cross_reference: MDR:10002071
database_cross_reference: MDR:10002082
database_cross_reference: MDR:10002272
database_cross_reference: MDR:10002315
database_cross_reference: MDR:10045627
database_cross_reference: MDR:10055742
database_cross_reference: MEDCIN:30320
database_cross_reference: MEDLINEPLUS:139
database_cross_reference: MSH:D000740
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000161
database_cross_reference: MTH:U000164
database_cross_reference: MTHICD9:285.9
database_cross_reference: NCI:C2869
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_CTCAE:E10010
database_cross_reference: NCI_FDA:1706
database_cross_reference: NCI_NCI-GLOSS:CDR0000045360
database_cross_reference: NCI_NICHD:C2869
database_cross_reference: NDFRT:N0000000384
database_cross_reference: OMIM:MTHU002606
database_cross_reference: PDQ:CDR0000041382
database_cross_reference: PSY:02450
database_cross_reference: RCD:XE140
database_cross_reference: RCD:XM05A
database_cross_reference: RCDAE:XE140
database_cross_reference: RCDAE:XM05A
database_cross_reference: SNM:D-4010
database_cross_reference: SNMI:DC-10010
database_cross_reference: SNOMEDCT_US:154786001
database_cross_reference: SNOMEDCT_US:154812000
database_cross_reference: SNOMEDCT_US:191277004
database_cross_reference: SNOMEDCT_US:267531008
database_cross_reference: SNOMEDCT_US:271737000
database_cross_reference: SNOMEDCT_US:64593003

macrocytic anemia
type: Class
subclass of: anemia
PMOID: PMO:00033362
Subclass_of: anemia
Synonym: ANAEMIA MACROCYTIC
Synonym: ANEMIA MACROCYTIC
Synonym: Anaemia macrocytic
Synonym: Anaemia;macrocytic
Synonym: Anemia macrocytic
Synonym: Anemia, Macrocytic
Synonym: Anemia, Macrocytic [Disease/Finding]
Synonym: Anemia, macrocytic
Synonym: Anemia;macrocytic
Synonym: Anemias, Macrocytic
Tree Number: T10.8.10.4.4
database_cross_reference: AOD:0000005892
database_cross_reference: BI:BI00292
database_cross_reference: CCPSS:0062020
database_cross_reference: CHV:0000001128
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:ANEMIA MACROCYT
database_cross_reference: DO:DOID:2361
database_cross_reference: HPO:HP:0001972
database_cross_reference: ICPC2P:B81007
database_cross_reference: MDR:10002064
database_cross_reference: MDR:10002297
database_cross_reference: MDR:10025380
database_cross_reference: MDR:10025381
database_cross_reference: MDR:10074043
database_cross_reference: MEDCIN:30326
database_cross_reference: MSH:D000748
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:281.9
database_cross_reference: NCI:C34381
database_cross_reference: NDFRT:N0000000392
database_cross_reference: OMIM:MTHU009000
database_cross_reference: OMIM:MTHU038097
database_cross_reference: RCD:X20C6
database_cross_reference: RCD:X20C7
database_cross_reference: RCDAE:X20C6
database_cross_reference: RCDAE:X20C7
database_cross_reference: SNM:D-4016
database_cross_reference: SNMI:DC-10040
database_cross_reference: SNOMEDCT_US:191151004
database_cross_reference: SNOMEDCT_US:191277004
database_cross_reference: SNOMEDCT_US:234356001
database_cross_reference: SNOMEDCT_US:83414005

West Nile encephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in inflammation located in brain, has material basis in West Nile virus, which is transmitted by Culex, transmitted by Aedes, and transmitted by Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.
PMOID: PMO:00029451
Subclass_of: viral infectious disease
Synonym: ENCEPH WEST NILE FEVER
Synonym: Encephalitis, West Nile Fever
Synonym: WEST NILE FEVER ENCEPH
Synonym: West Nile Fever Encephalitis
Synonym: West Nile Fever w/enceph
Synonym: West Nile Fever with encephalitis
Synonym: West Nile encephalitis (disorder)
Synonym: West Nile fever encephalitis
Synonym: West Nile fever with encephalitis
Synonym: West Nile fever with encephalitis (diagnosis)
Tree Number: T10.7.2.81
database_cross_reference: CHV:0000048463
database_cross_reference: DO:DOID:2365
database_cross_reference: ICD10CM:A92.31
database_cross_reference: ICD9CM:066.41
database_cross_reference: MEDCIN:275287
database_cross_reference: MSH:D014901
database_cross_reference: MTHICD9:066.41
database_cross_reference: SNOMEDCT_US:392662004
database_cross_reference: SNOMEDCT_VET:392662004

West Nile fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting.
PMOID: PMO:00029394
Subclass_of: viral infectious disease
Synonym: Disease caused by West Nile virus
Synonym: Disease caused by West Nile virus (disorder)
Synonym: Disease due to West Nile virus
Synonym: Disease due to West Nile virus (disorder)
Synonym: WEST NILE FEVER
Synonym: WN - West Nile fever
Synonym: West Nile Fever
Synonym: West Nile Fever NOS
Synonym: West Nile Fever [Disease/Finding]
Synonym: West Nile Fever, unspecified
Tree Number: T10.7.2.38
database_cross_reference: CHV:0000013146
database_cross_reference: DO:DOID:2366
database_cross_reference: DXP:U002023
database_cross_reference: ICD10:A92.3
database_cross_reference: ICD10AM:A92.3
database_cross_reference: ICD10CM:A92.3
database_cross_reference: ICD10CM:A92.30
database_cross_reference: ICD9CM:066.4
database_cross_reference: ICD9CM:066.40
database_cross_reference: LCH_NW:sh00009585
database_cross_reference: LNC:LA10519-9
database_cross_reference: MEDCIN:30834
database_cross_reference: MSH:D014901
database_cross_reference: MTHICD9:066.40
database_cross_reference: NDFRT:N0000003161
database_cross_reference: RCD:A663C
database_cross_reference: SNM:D-0503
database_cross_reference: SNMI:DE-33230
database_cross_reference: SNOMEDCT_US:12381007
database_cross_reference: SNOMEDCT_US:417093003
database_cross_reference: SNOMEDCT_VET:417093003

hereditary elliptocytosis
type: Class
subclass of: hematopoietic system disease
definition: A hematopoietic system disease characterized by oval or elliptical red blood cells, slight or absent hemolysis with little or no anemia; splenomegaly is often present.
PMOID: PMO:00033324
Subclass_of: hematopoietic system disease
Synonym: Congenital elliptocytosis
Synonym: Congenital elliptocytosis (disorder)
Synonym: Congenital elliptocytosis, NOS
Synonym: Congenital ovalocytosis
Synonym: Congenital ovalocytosis, NOS
Synonym: ELLIPTOCYTOSIS, HEREDITARY
Synonym: Elliptocytoses, Hereditary
Synonym: Elliptocytosis
Synonym: Elliptocytosis (congenital)
Synonym: Elliptocytosis hereditary
Tree Number: T10.8.10.3
database_cross_reference: CHV:0000004368
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0427-1524
database_cross_reference: DO:DOID:2373
database_cross_reference: DXP:U000516
database_cross_reference: HPO:HP:0004445
database_cross_reference: ICD10:D58.1
database_cross_reference: ICD10AM:D58.1
database_cross_reference: ICD10CM:D58.1
database_cross_reference: ICD9CM:282.1
database_cross_reference: MDR:10014490
database_cross_reference: MDR:10019877
database_cross_reference: MEDCIN:273614
database_cross_reference: MEDCIN:30341
database_cross_reference: MSH:D004612
database_cross_reference: MTH:U001883
database_cross_reference: MTHICD9:282.1
database_cross_reference: NCI:C35882
database_cross_reference: NDFRT:N0000001064
database_cross_reference: OMIM:MTHU027001
database_cross_reference: RCD:D101.
database_cross_reference: SNM:D-4103
database_cross_reference: SNMI:DC-15300
database_cross_reference: SNOMEDCT_US:154801000
database_cross_reference: SNOMEDCT_US:178935009
database_cross_reference: SNOMEDCT_US:191169008
database_cross_reference: SNOMEDCT_US:267558001
database_cross_reference: SNOMEDCT_US:58864003

rhinosporidiosis
type: Class
subclass of: parasitic Ichthyosporea infectious disease
definition: A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.
PMOID: PMO:00029713
Subclass_of: parasitic Ichthyosporea infectious disease
Synonym: Infection by Rhinosporidium seeberi
Synonym: Rhinosporidiosis
Tree Number: T10.7.4.3.1
database_cross_reference: DO:DOID:2409

gangliocytoma
type: Class
subclass of: cell type cancer
PMOID: PMO:00025423
Subclass_of: cell type cancer
Synonym: GANGLIONEUROFIBROMA
Synonym: GANGLIONEUROMA
Synonym: GANGLIONEUROMA, BENIGN
Synonym: Gangliocytoma
Synonym: Gangliocytoma (morphologic abnormality)
Synonym: Gangliocytomas
Synonym: Ganglioneuroma
Synonym: Ganglioneuroma (Schwannian Stroma-Dominant)
Synonym: Ganglioneuroma (disorder)
Synonym: Ganglioneuroma (morphologic abnormality)
Tree Number: T10.2.1.1.11
database_cross_reference: AOD:0000004647
database_cross_reference: CHV:0000005343
database_cross_reference: DO:DOID:2426
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000693
database_cross_reference: HPO:HP:0003005
database_cross_reference: ICD10AM:M9490/0
database_cross_reference: LNC:LA26521-7
database_cross_reference: MDR:10017700
database_cross_reference: MDR:10017709
database_cross_reference: MSH:D005729
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3049
database_cross_reference: NCI:C6934
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3049
database_cross_reference: NDFRT:N0000001307
database_cross_reference: OMIM:MTHU010647
database_cross_reference: RCD:BBc00
database_cross_reference: RCD:X77pU
database_cross_reference: SNM:M-9490/0
database_cross_reference: SNMI:M-94900
database_cross_reference: SNOMEDCT_US:116371000119107
database_cross_reference: SNOMEDCT_US:128919000
database_cross_reference: SNOMEDCT_US:189929007
database_cross_reference: SNOMEDCT_US:53801007

hyperpituitarism
type: Class
subclass of: pituitary gland disease
definition: A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb.
PMOID: PMO:00033210
Subclass_of: pituitary gland disease
Synonym: ACROMEGALY
Synonym: Acromegalia
Synonym: Acromegaly
Synonym: Acromegaly (disorder)
Synonym: Acromegaly [Disease/Finding]
Synonym: Anterior pituitary adenoma syndrome
Synonym: Eosinophilic adenoma syndrome
Synonym: Growth hormone hypersecretion syndrome
Synonym: Hypersecretion Syndrome, Somatotropin (Acromegaly)
Synonym: Hypersecretion Syndromes, Somatotropin (Acromegaly)
Tree Number: T10.8.8.5.1
database_cross_reference: AOD:0000005974
database_cross_reference: CCPSS:1000305
database_cross_reference: CHV:0000000657
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2335-8651
database_cross_reference: DO:DOID:2444
database_cross_reference: DO:DOID:2449
database_cross_reference: DXP:U000030
database_cross_reference: DXP:U000081
database_cross_reference: HPO:HP:0000845
database_cross_reference: ICPC2P:T99001
database_cross_reference: LCH:U000044
database_cross_reference: LCH_NW:sh85000666
database_cross_reference: MDR:10000599
database_cross_reference: MEDCIN:275521
database_cross_reference: MEDLINEPLUS:265
database_cross_reference: MEDLINEPLUS:362
database_cross_reference: MSH:D000172
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84533
database_cross_reference: NCI_NCI-GLOSS:CDR0000476630
database_cross_reference: NCI_NICHD:C84533
database_cross_reference: NDFRT:N0000000295
database_cross_reference: OMIM:MTHU016146
database_cross_reference: RCD:C1302
database_cross_reference: SNM:D-2141
database_cross_reference: SNMI:DB-11220
database_cross_reference: SNOMEDCT_US:154698000
database_cross_reference: SNOMEDCT_US:267480001
database_cross_reference: SNOMEDCT_US:74107003

protein S deficiency
type: Class
subclass of: blood protein disease
PMOID: PMO:00033295
Subclass_of: blood protein disease
Synonym: DEFIC PROTEIN S
Synonym: Deficiencies, Protein S
Synonym: Deficiency, Protein S
Synonym: Hereditary Thrombophilia Due To Protein S Deficiency
Synonym: PROTEIN S DEFIC
Synonym: Protein S Deficiencies
Synonym: Protein S Deficiency
Synonym: Protein S Deficiency Disease
Synonym: Protein S Deficiency [Disease/Finding]
Synonym: Protein S deficiency
Tree Number: T10.8.10.2.1
database_cross_reference: CHV:0000024912
database_cross_reference: DO:DOID:2451
database_cross_reference: HPO:HP:0004855
database_cross_reference: ICD10CM:D68.59
database_cross_reference: LCH_NW:sh87007326
database_cross_reference: MDR:10051292
database_cross_reference: MEDCIN:35807
database_cross_reference: MSH:D018455
database_cross_reference: MTHICD9:289.81
database_cross_reference: NCI:C99026
database_cross_reference: NCI_NICHD:C99026
database_cross_reference: NDFRT:N0000003818
database_cross_reference: OMIM:MTHU038923
database_cross_reference: RCD:D309.
database_cross_reference: SNMI:DC-65310
database_cross_reference: SNOMEDCT_US:1563006

thrombophilia
type: Class
subclass of: blood coagulation disease
PMOID: PMO:00033294
Subclass_of: blood coagulation disease
Synonym: Blood hyperviscosity
Synonym: Excessive Blood Clotting
Synonym: HYPERCOAGULABLE STATE
Synonym: HYPERCOAGULATION
Synonym: Hypercoaguability
Synonym: Hypercoagulabilities
Synonym: Hypercoagulability
Synonym: Hypercoagulability State
Synonym: Hypercoagulability state
Synonym: Hypercoagulability state (finding)
Tree Number: T10.8.10.1.4
database_cross_reference: CCPSS:0026526
database_cross_reference: CHV:0000032391
database_cross_reference: CHV:0000038554
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:COAGUL DIS
database_cross_reference: DO:DOID:2452
database_cross_reference: HPO:HP:0100724
database_cross_reference: ICD10CM:D68.59
database_cross_reference: MDR:10020608
database_cross_reference: MDR:10057396
database_cross_reference: MDR:10075816
database_cross_reference: MEDCIN:313610
database_cross_reference: MEDLINEPLUS:6076
database_cross_reference: MSH:D019851
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84479
database_cross_reference: NCI_NICHD:C84479
database_cross_reference: NDFRT:N0000003961
database_cross_reference: OMIM:MTHU054815
database_cross_reference: RCD:X20Ej
database_cross_reference: SNM:F-54360
database_cross_reference: SNMI:F-D0750
database_cross_reference: SNOMEDCT_US:191302007
database_cross_reference: SNOMEDCT_US:234467004
database_cross_reference: SNOMEDCT_US:76612001

psychotic disorder
type: Class
subclass of: cognitive disorder
PMOID: PMO:00028165
Subclass_of: cognitive disorder
Synonym: ATYPICAL PSYCHOSIS
Synonym: Atypical Psychoses
Synonym: Atypical psychosis
Synonym: Disorder, Psychotic
Synonym: Disorders, Psychotic
Synonym: General Psychoses
Synonym: PSYCHOSES
Synonym: PSYCHOSIS
Synonym: PSYCHOSIS ATYPICAL
Synonym: PSYCHOTIC DIS
Tree Number: T10.3.12.1
database_cross_reference: AOD:0000004324
database_cross_reference: BI:BI00688
database_cross_reference: CCPSS:0010478
database_cross_reference: CCPSS:1003395
database_cross_reference: CCPSS:1016056
database_cross_reference: CCPSS:1018204
database_cross_reference: CHV:0000010350
database_cross_reference: COSTAR:089
database_cross_reference: COSTAR:626
database_cross_reference: CSP:2484-8182
database_cross_reference: CST:NERPSYCH
database_cross_reference: CST:PSYCHOSIS
database_cross_reference: DXP:U003257
database_cross_reference: HPO:HP:0000709
database_cross_reference: ICD9CM:290-299.99
database_cross_reference: ICD9CM:298.9
database_cross_reference: ICPC2P:P98003
database_cross_reference: ICPC2P:P98004
database_cross_reference: LCH_NW:sh85108502
database_cross_reference: LNC:LA7534-6
database_cross_reference: MDR:10037234
database_cross_reference: MDR:10037241
database_cross_reference: MDR:10037248
database_cross_reference: MDR:10037253
database_cross_reference: MDR:10046122
database_cross_reference: MDR:10059419
database_cross_reference: MDR:10061920
database_cross_reference: MEDCIN:32748
database_cross_reference: MEDCIN:90018
database_cross_reference: MEDLINEPLUS:4180
database_cross_reference: MSH:D011618
database_cross_reference: MTH:089
database_cross_reference: MTH:626
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:298.9
database_cross_reference: NCI:C78576
database_cross_reference: NCI_CTCAE:E12954
database_cross_reference: NCI_NCI-GLOSS:CDR0000450115
database_cross_reference: NCI_NICHD:C78576
database_cross_reference: NDFRT:N0000002532
database_cross_reference: OMIM:MTHU002910
database_cross_reference: PSY:41910
database_cross_reference: RCD:X00S6
database_cross_reference: SNM:D-9030
database_cross_reference: SNM:D-9200
database_cross_reference: SNM:NOCODE
database_cross_reference: SNM:U000023
database_cross_reference: SNMI:D9-72000
database_cross_reference: SNOMEDCT_US:192347006
database_cross_reference: SNOMEDCT_US:231483000
database_cross_reference: SNOMEDCT_US:69322001

opportunistic mycosis
type: Class
subclass of: systemic mycosis
definition: A systemic mycosis that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.
PMOID: PMO:00029312
Subclass_of: systemic mycosis
Synonym: Opportunistic mycoses
Synonym: Opportunistic mycoses (disorder)
Synonym: Opportunistic mycosis
Synonym: Opportunistic mycosis (disorder)
Synonym: Opportunistic mycosis, NOS
Synonym: opportunistic mycoses
Synonym: opportunistic mycoses (diagnosis)
Synonym: opportunistic systemic mycoses
Tree Number: T10.7.1.4.1
database_cross_reference: DO:DOID:2473
database_cross_reference: ICD10:B48.7
database_cross_reference: ICD10AM:B48.7
database_cross_reference: ICD9CM:118
database_cross_reference: MDR:10030902
database_cross_reference: MDR:10058836
database_cross_reference: MEDCIN:99661
database_cross_reference: RCD:AB7..
database_cross_reference: SNMI:DE-40010
database_cross_reference: SNOMEDCT_US:187108005
database_cross_reference: SNOMEDCT_US:78999002

phosphorus metabolism disease
type: Class
subclass of: mineral metabolism disease
PMOID: PMO:00028928
Subclass_of: mineral metabolism disease
Synonym: Dis phosphorus metabol
Synonym: Disorder of phosphorus NOS
Synonym: Disorder of phosphorus metabolism
Synonym: Disorder of phosphorus metabolism (disorder)
Synonym: Disorder of phosphorus metabolism NOS
Synonym: Disorder of phosphorus metabolism NOS (disorder)
Synonym: Disorder of phosphorus metabolism, NOS
Synonym: Disorder, Phosphorus Metabolism
Synonym: Disorders of phosphorus metab.
Synonym: Disorders of phosphorus metabolism
Tree Number: T10.6.1.5.3
database_cross_reference: AOD:0000005767
database_cross_reference: AOD:0000023457
database_cross_reference: CSP:0531-8952
database_cross_reference: CST:MAN/ION/P
database_cross_reference: DO:DOID:2485
database_cross_reference: ICD10:E83.3
database_cross_reference: ICD10AM:E83.3
database_cross_reference: ICD9CM:275.3
database_cross_reference: LCH_NW:sh85101122
database_cross_reference: MDR:10013346
database_cross_reference: MDR:10034940
database_cross_reference: MDR:10034941
database_cross_reference: MDR:10061347
database_cross_reference: MEDCIN:337576
database_cross_reference: MSH:D010760
database_cross_reference: MTH:U000308
database_cross_reference: NCI:C97095
database_cross_reference: NDFRT:N0000002395
database_cross_reference: RCD:C353.
database_cross_reference: RCD:C353z
database_cross_reference: SNMI:D6-34100
database_cross_reference: SNOMEDCT_US:154752005
database_cross_reference: SNOMEDCT_US:190858002
database_cross_reference: SNOMEDCT_US:190862008
database_cross_reference: SNOMEDCT_US:267505006
database_cross_reference: SNOMEDCT_US:87049008

congenital nervous system abnormality
type: Class
subclass of: physical disorder
PMOID: PMO:00028237
Subclass_of: physical disorder
Synonym: Other congenital anomalies of nervous system
Synonym: Other nerv.sys.congenital anom
Synonym: Other nervous system congenital anomalies
Synonym: Other nervous system congenital anomalies (disorder)
Synonym: congenital neurologic anomaly
Tree Number: T10.4.1
database_cross_reference: DO:DOID:2490
database_cross_reference: ICD9CM:742
database_cross_reference: MDR:10031827
database_cross_reference: RCD:P2...
database_cross_reference: SNOMEDCT_US:204018008

angiodysplasia
type: Class
subclass of: vascular disease
definition: A vascular disease that is characterized as a small vascular malformation of the gut.
PMOID: PMO:00032000
Subclass_of: vascular disease
Synonym: ANGIODYSPLASIA
Synonym: Angiodysplasia
Synonym: Angiodysplasia (morphologic abnormality)
Synonym: Angiodysplasia NOS
Synonym: Angiodysplasia [Disease/Finding]
Synonym: Angiodysplasias
Synonym: angiodysplasia of stomach and duodenum with hemorrhage
Synonym: angiodysplasias
Tree Number: T10.8.3.3.11
database_cross_reference: CCPSS:0051243
database_cross_reference: CHV:0000015591
database_cross_reference: DO:DOID:2494
database_cross_reference: MDR:10051846
database_cross_reference: MDR:10061636
database_cross_reference: MSH:D016888
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003501
database_cross_reference: OMIM:MTHU006470
database_cross_reference: SNM:M-74850
database_cross_reference: SNMI:M-74800
database_cross_reference: SNOMEDCT_US:71072006

Takayasu's arteritis
type: Class
subclass of: syndrome
definition: A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body.
PMOID: PMO:00025171
Subclass_of: syndrome
Synonym: Aortic Arch Syndrome
Synonym: Aortic Arch Syndromes
Synonym: Aortic Arch Syndromes [Disease/Finding]
Synonym: Aortic Arch syndrome
Synonym: Aortic arch arteritis
Synonym: Aortic arch syndrome
Synonym: Idiopathic aortitis
Synonym: Syndrome, Aortic Arch
Synonym: Syndromes, Aortic Arch
Synonym: Takayasu arteritis
Tree Number: T10.1.52
database_cross_reference: CHV:0000001351
database_cross_reference: DO:DOID:2508
database_cross_reference: MDR:10002890
database_cross_reference: MSH:D001015
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34391
database_cross_reference: NDFRT:N0000000438
database_cross_reference: RCD:XE2QH
database_cross_reference: SNM:D-7368
database_cross_reference: SNOMEDCT_US:359789008

Kluver-Bucy syndrome
type: Class
subclass of: impulse control disorder
definition: An impulse control disorder that involves abnormalities in memory, social and sexual functioning and idiosyncratic behaviors resulting from damage from trauma or infection to both temporal lobes causing individuals to put objects in their mouths and engage in inappropriate sexual behavior.
PMOID: PMO:00028137
Subclass_of: impulse control disorder
Synonym: Kluver Bucy Syndrome
Synonym: Kluver-Bucy Syndrome
Synonym: Kluver-Bucy Syndrome [Disease/Finding]
Synonym: Klver-Bucy syndrome
Synonym: Klüver-Bucy syndrome
Synonym: Syndrome, Kluver-Bucy
Synonym: kluver bucy syndrome
Synonym: kluver-bucy syndrome
Tree Number: T10.3.7.5
database_cross_reference: CHV:0000026502
database_cross_reference: DO:DOID:2510
database_cross_reference: MDR:10066431
database_cross_reference: MSH:D020232
database_cross_reference: NCI:C84802
database_cross_reference: NDFRT:N0000004062
database_cross_reference: OMIM:MTHU006537
database_cross_reference: SNM:D-8533
database_cross_reference: SNMI:DA-13560
database_cross_reference: SNOMEDCT_US:10651001

testicular disease
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029770
Subclass_of: male reproductive system disease
Synonym: DISORDER TESTICLE
Synonym: Disease of testis
Synonym: Disease of testis (disorder)
Synonym: Disease of testis, NOS
Synonym: Disease, Testicular
Synonym: Diseases of Testis
Synonym: Diseases, Testicular
Synonym: Disorder of testis
Synonym: Disorder of testis (disorder)
Synonym: Disorder of testis, NOS
Tree Number: T10.8.1.3.11
database_cross_reference: CHV:0000012114
database_cross_reference: CSP:2587-6706
database_cross_reference: CST:ENDO/TEST
database_cross_reference: CST:TESTIS DIS
database_cross_reference: CST:UG/MG/TEST
database_cross_reference: DO:DOID:2519
database_cross_reference: LCH_NW:sh85134158
database_cross_reference: MDR:10013273
database_cross_reference: MDR:10043306
database_cross_reference: MDR:10043307
database_cross_reference: MDR:10043361
database_cross_reference: MEDCIN:95372
database_cross_reference: MEDLINEPLUS:4280
database_cross_reference: MSH:D013733
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26890
database_cross_reference: NCI_CTCAE:E13215
database_cross_reference: NCI_NICHD:C26890
database_cross_reference: NDFRT:N0000002912
database_cross_reference: PSY:52300
database_cross_reference: RCD:X400T
database_cross_reference: RCD:Xa6aQ
database_cross_reference: SNM:D-2650
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D7-55000
database_cross_reference: SNOMEDCT_US:236763001
database_cross_reference: SNOMEDCT_US:297228003
database_cross_reference: SNOMEDCT_US:64910008

nephrosis
type: Class
subclass of: kidney disease
definition: A kidney disease that is characterized by the leaking of blood protein into the urine, swelling or edema, and degenerative lesions without inflammation.
PMOID: PMO:00033078
Subclass_of: kidney disease
Synonym: -- Nephrosis
Synonym: NEPHROSIS
Synonym: Nephroses
Synonym: Nephrosis
Synonym: Nephrosis NOS
Synonym: Nephrosis [Disease/Finding]
Synonym: Nephrosis, NOS
Synonym: nephroses
Tree Number: T10.8.7.9.23
database_cross_reference: AOD:0000023506
database_cross_reference: CHV:0000008587
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1682-1676
database_cross_reference: CST:NEPHROSIS
database_cross_reference: CST:RENALNEPH
database_cross_reference: DO:DOID:2527
database_cross_reference: ICPC2P:U88002
database_cross_reference: LNC:LA10567-8
database_cross_reference: MDR:10029161
database_cross_reference: MSH:D009401
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:581.9
database_cross_reference: NDFRT:N0000002153
database_cross_reference: OMIM:MTHU017719
database_cross_reference: SNM:M-53100
database_cross_reference: SNM:U000345
database_cross_reference: SNMI:D7-11000
database_cross_reference: SNOMEDCT_US:90708001

splenic disease
type: Class
subclass of: lymphatic system disease
PMOID: PMO:00032924
Subclass_of: lymphatic system disease
Synonym: DISEASES OF THE SPLEEN
Synonym: DISORDER SPLEEN
Synonym: Disease of spleen
Synonym: Disease of spleen (disorder)
Synonym: Disease of spleen NOS
Synonym: Disease of spleen NOS (disorder)
Synonym: Disease of spleen unspecified
Synonym: Disease of spleen unspecified (disorder)
Synonym: Disease of spleen, NOS
Synonym: Disease of spleen, unspecified
Tree Number: T10.8.6.4.4
database_cross_reference: AOD:0000005959
database_cross_reference: CHV:0000011643
database_cross_reference: CSP:0427-9136
database_cross_reference: CST:HAL/SPLN
database_cross_reference: CST:SPLEEN DIS
database_cross_reference: DO:DOID:2529
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:D73
database_cross_reference: ICD10:D73.9
database_cross_reference: ICD10AM:D73
database_cross_reference: ICD10AM:D73.9
database_cross_reference: ICD10CM:D73
database_cross_reference: ICD10CM:D73.9
database_cross_reference: ICD9CM:289.50
database_cross_reference: ICPC2P:B99019
database_cross_reference: LCH_NW:sh85126816
database_cross_reference: MDR:10013111
database_cross_reference: MDR:10013271
database_cross_reference: MDR:10041633
database_cross_reference: MDR:10041634
database_cross_reference: MDR:10041635
database_cross_reference: MEDCIN:38668
database_cross_reference: MEDLINEPLUS:414
database_cross_reference: MSH:D013158
database_cross_reference: MTHICD9:289.4
database_cross_reference: NCI:C35823
database_cross_reference: NCI_CTCAE:E10056
database_cross_reference: NDFRT:N0000002804
database_cross_reference: RCD:D4150
database_cross_reference: RCD:D415z
database_cross_reference: RCD:X20FZ
database_cross_reference: SNM:D-4120
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DC-80000
database_cross_reference: SNMI:DC-80100
database_cross_reference: SNOMEDCT_US:154839008
database_cross_reference: SNOMEDCT_US:191381002
database_cross_reference: SNOMEDCT_US:191385006
database_cross_reference: SNOMEDCT_US:267570002
database_cross_reference: SNOMEDCT_US:51244008
database_cross_reference: SNOMEDCT_US:58381000
database_cross_reference: SNOMEDCT_VET:51244008

hemangioma
type: Class
subclass of: cell type benign neoplasm
PMOID: PMO:00027323
Subclass_of: cell type benign neoplasm
Synonym: Angioma of Placenta
Synonym: Angioma of the Placenta
Synonym: Chorangioma
Synonym: Chorangioma (morphologic abnormality)
Synonym: Chorangioma Placentae
Synonym: Chorangioma of the Placenta
Synonym: Chorangiomas
Synonym: Chorioangioma
Synonym: Chorioangioma (disorder)
Synonym: Chorioangiomas
Tree Number: T10.2.3.1.3
database_cross_reference: CHV:0000042638
database_cross_reference: DO:DOID:277
database_cross_reference: HPO:HP:0001028
database_cross_reference: HPO:HP:0100883
database_cross_reference: MDR:10056718
database_cross_reference: MSH:D006391
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4868
database_cross_reference: NCI_NICHD:C4868
database_cross_reference: RCD:X40Bl
database_cross_reference: SNM:M-9120/0
database_cross_reference: SNMI:M-91200
database_cross_reference: SNOMEDCT_US:2099007
database_cross_reference: SNOMEDCT_US:237268002
database_cross_reference: SNOMEDCT_US:699948001

rhizomelic chondrodysplasia punctata
type: Class
subclass of: chondrodysplasia punctata
definition: A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has material basis in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene.
PMOID: PMO:00028830
Subclass_of: chondrodysplasia punctata
Synonym: CDPR
Synonym: CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC FORM
Synonym: Chondrodysp punctata recessive
Synonym: Chondrodysplasia Punctata, Rhizomelic
Synonym: Chondrodysplasia Punctata, Rhizomelic Form
Synonym: Chondrodysplasia Punctata, Rhizomelic [Disease/Finding]
Synonym: Chondrodysplasia Punctatas, Rhizomelic
Synonym: Chondrodysplasia punctata, autosomal recessive type
Synonym: Chondrodysplasia punctata, rhizomelic type
Synonym: Punctata, Rhizomelic Chondrodysplasia
Tree Number: T10.5.10.1
database_cross_reference: DO:DOID:2580
database_cross_reference: ICD10CM:E71.540
database_cross_reference: MEDCIN:312733
database_cross_reference: MSH:D018902
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.86
database_cross_reference: NCI:C85047
database_cross_reference: NCI_NICHD:C85047
database_cross_reference: NDFRT:N0000003877
database_cross_reference: OMIM:215100
database_cross_reference: RCD:X40Wj
database_cross_reference: SNM:D-5249
database_cross_reference: SNMI:D4-00A62
database_cross_reference: SNOMEDCT_US:56692003

chondrodysplasia punctata
type: Class
subclass of: genetic disease
PMOID: PMO:00028829
Subclass_of: genetic disease
Synonym: CHONDRODYSTROPHIA CALCIFICANS CONGEN
Synonym: Chondrdys punct stipl epiph gr
Synonym: Chondrodysplasia Punctata
Synonym: Chondrodysplasia Punctata (Stippled Epiphyses) Group
Synonym: Chondrodysplasia Punctata [Disease/Finding]
Synonym: Chondrodysplasia calcificans
Synonym: Chondrodysplasia calcificans congenita
Synonym: Chondrodysplasia punctata
Synonym: Chondrodysplasia punctata (disorder)
Synonym: Chondrodysplasia punctata (disorder) [Ambiguous]
Tree Number: T10.5.10
database_cross_reference: CHV:0000002898
database_cross_reference: DO:DOID:2581
database_cross_reference: HPO:HP:0010655
database_cross_reference: ICD10:Q77.3
database_cross_reference: ICD10AM:Q77.3
database_cross_reference: ICD10CM:Q77.3
database_cross_reference: MEDCIN:330544
database_cross_reference: MSH:D002806
database_cross_reference: MTH:U003262
database_cross_reference: NCI:C84632
database_cross_reference: NCI_NICHD:C84632
database_cross_reference: NDFRT:N0000000768
database_cross_reference: OMIM:MTHU050816
database_cross_reference: RCD:PG4C.
database_cross_reference: RCD:Xa0pI
database_cross_reference: SNM:M-22410
database_cross_reference: SNM:M-22750
database_cross_reference: SNMI:D4-00A60
database_cross_reference: SNOMEDCT_US:205486004
database_cross_reference: SNOMEDCT_US:22932004
database_cross_reference: SNOMEDCT_US:278715001
database_cross_reference: SNOMEDCT_US:360507004
database_cross_reference: SNOMEDCT_US:42778005

acatalasia
type: Class
subclass of: peroxisomal disease
PMOID: PMO:00029240
Subclass_of: peroxisomal disease
Synonym: ACATALASEMIA
Synonym: ACATALASIA
Synonym: Acatalasaemia
Synonym: Acatalasemia
Synonym: Acatalasemia (disorder)
Synonym: Acatalasia
Synonym: Acatalasia (disorder)
Synonym: Acatalasia [Disease/Finding]
Synonym: CATALASE DEFICIENCY
Synonym: Catalase deficiency
Tree Number: T10.6.2.16.3
database_cross_reference: CHV:0000026305
database_cross_reference: DO:DOID:2582
database_cross_reference: MSH:D020642
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84526
database_cross_reference: NDFRT:N0000004165
database_cross_reference: OMIM:614097
database_cross_reference: RCD:C37y4
database_cross_reference: RCD:XE11q
database_cross_reference: RCDAE:XE11q
database_cross_reference: SNM:D-1061
database_cross_reference: SNMI:D6-95400
database_cross_reference: SNOMEDCT_US:111393000
database_cross_reference: SNOMEDCT_US:190954001
database_cross_reference: SNOMEDCT_US:267454002

pancreas disease
type: Class
subclass of: endocrine system disease
PMOID: PMO:00033194
Subclass_of: endocrine system disease
Synonym: DISEASES OF THE PANCREAS
Synonym: DISORDER PANCREAS
Synonym: Disease of pancreas
Synonym: Disease of pancreas (disorder)
Synonym: Disease of pancreas, NOS
Synonym: Disease of pancreas, unspecified
Synonym: Disease, Pancreatic
Synonym: Disease;pancreas
Synonym: Diseases and Syndromes of Pancreas
Synonym: Diseases of pancreas
Tree Number: T10.8.8.4
database_cross_reference: AOD:0000005652
database_cross_reference: CCPSS:0042447
database_cross_reference: CHV:0000009218
database_cross_reference: CSP:2201-9924
database_cross_reference: CST:DIG/PAN
database_cross_reference: CST:PANCREAS DIS
database_cross_reference: HPO:HP:0001732
database_cross_reference: ICD10:K86.9
database_cross_reference: ICD10AM:K86.9
database_cross_reference: ICD10CM:K86.9
database_cross_reference: ICD9CM:577
database_cross_reference: ICD9CM:577.9
database_cross_reference: ICPC2P:D99053
database_cross_reference: LCH_NW:sh85097374
database_cross_reference: MDR:10013130
database_cross_reference: MDR:10013250
database_cross_reference: MDR:10033581
database_cross_reference: MDR:10033616
database_cross_reference: MDR:10033617
database_cross_reference: MDR:10045751
database_cross_reference: MEDCIN:90248
database_cross_reference: MEDLINEPLUS:110
database_cross_reference: MSH:D010182
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26842
database_cross_reference: NDFRT:N0000002285
database_cross_reference: RCD:J67..
database_cross_reference: RCD:J67z.
database_cross_reference: SNM:D-6390
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D5-90000
database_cross_reference: SNOMEDCT_US:155833000
database_cross_reference: SNOMEDCT_US:155836008
database_cross_reference: SNOMEDCT_US:197469006
database_cross_reference: SNOMEDCT_US:266546006
database_cross_reference: SNOMEDCT_US:3855007

chondroma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.
PMOID: PMO:00027411
Subclass_of: cell type benign neoplasm
Synonym: CHONDROMA, BENIGN
Synonym: Chondroma
Synonym: Chondroma (morphologic abnormality)
Synonym: Chondroma NOS
Synonym: Chondroma [Disease/Finding]
Synonym: Chondroma, NOS
Synonym: Chondromas
Synonym: [M]Chondroma NOS
Synonym: [M]Chondroma NOS (morphologic abnormality)
Synonym: central Chondroma
Tree Number: T10.2.3.1.11
database_cross_reference: AOD:0000004539
database_cross_reference: CHV:0000052862
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:2602
database_cross_reference: ICD10AM:M9220/0
database_cross_reference: MDR:10008725
database_cross_reference: MSH:D002812
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C53459
database_cross_reference: NCI_CDISC:C53459
database_cross_reference: NDFRT:N0000000769
database_cross_reference: RCD:BBW2.
database_cross_reference: RCD:Xa9AY
database_cross_reference: RCDSY:BBW2.
database_cross_reference: SNM:M-9220/0
database_cross_reference: SNMI:M-92200
database_cross_reference: SNOMEDCT_US:154611005
database_cross_reference: SNOMEDCT_US:187899007
database_cross_reference: SNOMEDCT_US:188980001
database_cross_reference: SNOMEDCT_US:189885004
database_cross_reference: SNOMEDCT_US:269638002
database_cross_reference: SNOMEDCT_US:31186001

papilloma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplam that is composed of epithelial tissue on papillae of vascularized connective tissue.
PMOID: PMO:00027380
Subclass_of: cell type benign neoplasm
Synonym: PAPILLOMA
Synonym: PAPILLOMA, BENIGN
Synonym: Papilloma
Synonym: Papilloma (disorder)
Synonym: Papilloma NOS
Synonym: Papilloma [Disease/Finding]
Synonym: Papilloma, NOS
Synonym: Papillomas
Synonym: Papillomata
Synonym: non cancerous skin tumor
Tree Number: T10.2.3.1.7
database_cross_reference: AOD:0000004529
database_cross_reference: CCPSS:0044946
database_cross_reference: CHV:0000009247
database_cross_reference: COSTAR:U000505
database_cross_reference: DO:DOID:2615
database_cross_reference: DXP:U003008
database_cross_reference: HPO:HP:0012740
database_cross_reference: LCH:U003462
database_cross_reference: LCH_NW:sh85097677
database_cross_reference: MDR:10033713
database_cross_reference: MDR:10033715
database_cross_reference: MDR:10033725
database_cross_reference: MEDCIN:6231
database_cross_reference: MSH:D010212
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C7440
database_cross_reference: NCI_CDISC:C7440
database_cross_reference: NDFRT:N0000002295
database_cross_reference: RCD:X77n9
database_cross_reference: SNM:M-8050/0
database_cross_reference: SNMI:M-80500
database_cross_reference: SNOMEDCT_US:23730008
database_cross_reference: SNOMEDCT_US:711329002

benign mesothelioma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that has_material_basis in mesothelium.
PMOID: PMO:00027317
Subclass_of: cell type benign neoplasm
Synonym: MESOTHELIOMA
Synonym: Mesothelioma
Synonym: Mesothelioma (disorder)
Synonym: Mesothelioma [Disease/Finding]
Synonym: Mesothelioma, NOS
Synonym: Mesothelioma, unspecified
Synonym: Mesotheliomas
Synonym: [M]Mesothelioma, unspecified
Synonym: [M]Mesothelioma, unspecified (morphologic abnormality)
Synonym: [X]Mesothelioma, unspecified
Tree Number: T10.2.3.1.1
database_cross_reference: AOD:0000023022
database_cross_reference: CCPSS:0042479
database_cross_reference: CHV:0000007992
database_cross_reference: CSP:2005-3609
database_cross_reference: DO:DOID:2645
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:C45
database_cross_reference: ICD10:C45.9
database_cross_reference: ICD10AM:C45
database_cross_reference: ICD10AM:C45.9
database_cross_reference: ICD10CM:C45
database_cross_reference: ICD10CM:C45.9
database_cross_reference: ICPC2P:R85012
database_cross_reference: LCH:U002922
database_cross_reference: LCH_NW:sh85083965
database_cross_reference: MDR:10027406
database_cross_reference: MDR:10027412
database_cross_reference: MEDLINEPLUS:4014
database_cross_reference: MSH:D008654
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3234
database_cross_reference: NCI_CTEP-SDC:10027410
database_cross_reference: NCI_NCI-GLOSS:CDR0000044323
database_cross_reference: NDFRT:N0000002003
database_cross_reference: OMIM:MTHU053482
database_cross_reference: PDQ:CDR0000038142
database_cross_reference: RCD:BBPX.
database_cross_reference: RCD:Byu51
database_cross_reference: RCD:X77ou
database_cross_reference: RCDSY:BBPX.
database_cross_reference: RCDSY:Byu51
database_cross_reference: SNM:M-9050/3
database_cross_reference: SNMI:M-90503
database_cross_reference: SNOMEDCT_US:154491004
database_cross_reference: SNOMEDCT_US:187873000
database_cross_reference: SNOMEDCT_US:189837000
database_cross_reference: SNOMEDCT_US:190110008
database_cross_reference: SNOMEDCT_US:62064005
database_cross_reference: SNOMEDCT_VET:115232000

adenofibroma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that is composed_of glandular and fibrous tissues, with a relatively large proportion of glands.
PMOID: PMO:00027417
Subclass_of: cell type benign neoplasm
Synonym: ADENOFIBROMA, BENIGN
Synonym: Adenofibroma
Synonym: Adenofibroma (disorder)
Synonym: Adenofibroma NOS
Synonym: Adenofibroma [Disease/Finding]
Synonym: Adenofibroma, NOS
Synonym: Adenofibroma, no ICD-O subtype
Synonym: Adenofibroma, no ICD-O subtype (morphologic abnormality)
Synonym: Adenofibroma, no International Classification of Diseases for Oncology subtype
Synonym: Adenofibroma, no International Classification of Diseases for Oncology subtype (morphologic abnormality)
Tree Number: T10.2.3.1.15
database_cross_reference: CHV:0000000711
database_cross_reference: DO:DOID:2683
database_cross_reference: ICD10AM:M9013/0
database_cross_reference: MDR:10072991
database_cross_reference: MSH:D000232
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C8984
database_cross_reference: NCI_CDISC:C8984
database_cross_reference: NDFRT:N0000000308
database_cross_reference: RCD:Xa9A5
database_cross_reference: RCDSY:Xa9A5
database_cross_reference: SNM:M-9013/0
database_cross_reference: SNMI:M-90130
database_cross_reference: SNOMEDCT_US:189823009
database_cross_reference: SNOMEDCT_US:2962009

synovitis
type: Class
subclass of: connective tissue disease
definition: A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling.
PMOID: PMO:00032315
Subclass_of: connective tissue disease
Synonym: SYNOVITIS
Synonym: Synovitides
Synonym: Synovitis
Synonym: Synovitis (disorder)
Synonym: Synovitis NOS
Synonym: Synovitis [Disease/Finding]
Synonym: Synovitis, NOS
Synonym: synovitis (diagnosis)
Tree Number: T10.8.4.1.21
database_cross_reference: AOD:0000005142
database_cross_reference: CCPSS:0019259
database_cross_reference: CHV:0000011983
database_cross_reference: COSTAR:U000654
database_cross_reference: CSP:2715-3241
database_cross_reference: CST:SYNOVITIS
database_cross_reference: DO:DOID:2703
database_cross_reference: DXP:U003910
database_cross_reference: HPO:HP:0100769
database_cross_reference: ICPC2P:L87010
database_cross_reference: ICPC2P:L99039
database_cross_reference: LCH_NW:sh2001000030
database_cross_reference: MDR:10042868
database_cross_reference: MEDCIN:237606
database_cross_reference: MSH:D013585
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:727.00
database_cross_reference: NCI:C50766
database_cross_reference: NCI_FDA:2094
database_cross_reference: NCI_NCI-GLOSS:CDR0000430867
database_cross_reference: NDFRT:N0000002879
database_cross_reference: RCD:X702E
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D1-32020
database_cross_reference: SNOMEDCT_US:14107000
database_cross_reference: SNOMEDCT_US:156666009
database_cross_reference: SNOMEDCT_US:268092005
database_cross_reference: SNOMEDCT_US:416209007

hepatic vascular disease
type: Class
subclass of: vascular disease
definition: A vascular disease that is located_in the liver.
PMOID: PMO:00032001
Subclass_of: vascular disease
Synonym: Hepatic Vascular Disorder
Synonym: Hepatic vascular disorders
Synonym: Liver Vascular Disorder
Synonym: Vascular disorder of liver
Synonym: Vascular disorder of liver (disorder)
Synonym: vascular disorder of liver
Tree Number: T10.8.3.3.12
database_cross_reference: DO:DOID:272
database_cross_reference: MDR:10019712
database_cross_reference: NCI:C35442
database_cross_reference: RCD:X306u
database_cross_reference: SNOMEDCT_US:235878005

dermatitis
type: Class
subclass of: skin disease
definition: A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin.
PMOID: PMO:00033815
Subclass_of: skin disease
Synonym: Cutaneous inflammation
Synonym: DERMATITIS
Synonym: DERMATITIS (NOS)
Synonym: Dermatitides
Synonym: Dermatitis
Synonym: Dermatitis (NOS)
Synonym: Dermatitis (disorder)
Synonym: Dermatitis (disorder) [Ambiguous]
Synonym: Dermatitis NOS
Synonym: Dermatitis NOS (disorder)
Tree Number: T10.8.12.2.7
database_cross_reference: AOD:0000005192
database_cross_reference: BI:BI00582
database_cross_reference: CCPSS:0050959
database_cross_reference: CHV:0000003790
database_cross_reference: COSTAR:226
database_cross_reference: CSP:4008-0032
database_cross_reference: CST:RASH
database_cross_reference: DO:DOID:2723
database_cross_reference: HPO:HP:0011123
database_cross_reference: ICD10:L30.9
database_cross_reference: ICD10AM:L30.9
database_cross_reference: ICD10CM:L30.9
database_cross_reference: ICPC2P:S88005
database_cross_reference: LCH_NW:sh85123181
database_cross_reference: MDR:10012431
database_cross_reference: MDR:10012478
database_cross_reference: MDR:10040876
database_cross_reference: MDR:10048503
database_cross_reference: MDR:10062249
database_cross_reference: MEDCIN:3393
database_cross_reference: MEDLINEPLUS:1215
database_cross_reference: MEDLINEPLUS:208
database_cross_reference: MSH:D003872
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:692.9
database_cross_reference: NCI:C2983
database_cross_reference: NCI_FDA:2443
database_cross_reference: NCI_NCI-GLOSS:CDR0000045667
database_cross_reference: NDFRT:N0000000939
database_cross_reference: OMIM:MTHU001691
database_cross_reference: PSY:13710
database_cross_reference: RCD:M12z0
database_cross_reference: RCD:X505K
database_cross_reference: RCD:XE1Ca
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D0-00010
database_cross_reference: SNOMEDCT_US:156358005
database_cross_reference: SNOMEDCT_US:156388001
database_cross_reference: SNOMEDCT_US:182782007
database_cross_reference: SNOMEDCT_US:200884006
database_cross_reference: SNOMEDCT_US:238538009
database_cross_reference: SNOMEDCT_US:267847004
database_cross_reference: SNOMEDCT_US:267856007
database_cross_reference: SNOMEDCT_US:43116000
database_cross_reference: SNOMEDCT_US:4979002
database_cross_reference: SNOMEDCT_US:703938007
database_cross_reference: SNOMEDCT_VET:182782007
database_cross_reference: SNOMEDCT_VET:703938007

dyskeratosis congenita
type: Class
subclass of: skin disease
definition: A skin disease characterized by cutaneous pigmentation, premature graying, dystrophy of the nails, leukoplakia of the oral mucosa, continuous lacrimation due to atresia of the lacrimal ducts, often thrombocytopenia, anemia, testicular atrophy in the male carriers and predisposition to cancer.
PMOID: PMO:00033967
Subclass_of: skin disease
Synonym: Cole syndrome
Synonym: Cole-Engmann-Zinsser syndrome
Synonym: Cole-Rauschkolb-Toomey syndrome
Synonym: Congenital dyskeratosis
Synonym: DKC
Synonym: DKC - Dyskeratosis congenita
Synonym: Dyskeratosis Congenita
Synonym: Dyskeratosis Congenita [Disease/Finding]
Synonym: Dyskeratosis congenita
Synonym: Dyskeratosis congenita (disorder)
Tree Number: T10.8.12.2.44
database_cross_reference: CHV:0000025969
database_cross_reference: DO:DOID:2729
database_cross_reference: JABL:722
database_cross_reference: MDR:10062759
database_cross_reference: MSH:D019871
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C111802
database_cross_reference: NDFRT:N0000003963
database_cross_reference: PDQ:CDR0000285967
database_cross_reference: RCD:X20Di
database_cross_reference: SNM:D-5404
database_cross_reference: SNM:M-72620
database_cross_reference: SNMI:D4-40140
database_cross_reference: SNOMEDCT_US:74911008

vesiculobullous skin disease
type: Class
subclass of: skin disease
PMOID: PMO:00033772
Subclass_of: skin disease
Synonym: Dermatoses, Vesiculobullous
Synonym: SKIN DIS VESICULOBULLOUS
Synonym: Skin Disease, Vesiculobullous
Synonym: Skin Diseases, Vesiculobullous
Synonym: Skin Diseases, Vesiculobullous [Disease/Finding]
Synonym: VESICULOBULLOUS SKIN DIS
Synonym: Vesiculobullous Dermatoses
Synonym: Vesiculobullous Skin Disease
Synonym: Vesiculobullous Skin Diseases
Synonym: Vesiculobullous dermatosis
Tree Number: T10.8.12.2.1
database_cross_reference: DO:DOID:2731
database_cross_reference: MSH:D012872
database_cross_reference: NDFRT:N0000002762
database_cross_reference: SNM:D-3600

Rothmund-Thomson syndrome
type: Class
subclass of: skin disease
PMOID: PMO:00033981
Subclass_of: skin disease
Synonym: Congenital Poikiloderma
Synonym: Congenital poikiloderma
Synonym: Congenitale, Poikiloderma
Synonym: Congenitales, Poikiloderma
Synonym: POIKILODERMA ATROPHICANS AND CATARACT
Synonym: POIKILODERMA CONGEN
Synonym: Poikiloderma Atrophicans and Cataract
Synonym: Poikiloderma Congenitale
Synonym: Poikiloderma Congenitale of Rothmund-Thomson
Synonym: Poikiloderma Congenitales
Tree Number: T10.8.12.2.45
database_cross_reference: CHV:0000009884
database_cross_reference: DO:DOID:2732
database_cross_reference: ICD10CM:Q82.8
database_cross_reference: MDR:10052465
database_cross_reference: MDR:10052510
database_cross_reference: MEDCIN:272072
database_cross_reference: MSH:D011038
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:757.33
database_cross_reference: NCI:C3335
database_cross_reference: NCI_NCI-GLOSS:CDR0000662024
database_cross_reference: NCI_NCI-GLOSS:CDR0000662025
database_cross_reference: NDFRT:N0000171676
database_cross_reference: OMIM:268400
database_cross_reference: OMIM:603780
database_cross_reference: OMIM:MTHU046823
database_cross_reference: RCD:PH320
database_cross_reference: SNM:D-5021
database_cross_reference: SNM:M-58580
database_cross_reference: SNMI:D4-00403
database_cross_reference: SNOMEDCT_US:205565002
database_cross_reference: SNOMEDCT_US:205572001
database_cross_reference: SNOMEDCT_US:69093006

skin atrophy
type: Class
subclass of: skin disease
PMOID: PMO:00033788
Subclass_of: skin disease
Synonym: ATROPHY SKIN
Synonym: Atrophic
Synonym: Atrophic Skin
Synonym: Atrophic condition of skin
Synonym: Atrophic condition of skin (disorder)
Synonym: Atrophic condition of skin, NOS
Synonym: Atrophic disorder of skin, unspecified
Synonym: Atrophic disorders of skin
Synonym: Atrophic skin
Synonym: Atrophoderma
Tree Number: T10.8.12.2.4
database_cross_reference: CHV:0000016981
database_cross_reference: COSTAR:U000625
database_cross_reference: CST:ATROPHY SKIN
database_cross_reference: CST:SKIN/DERM/ATR
database_cross_reference: DO:DOID:2733
database_cross_reference: DXP:U003579
database_cross_reference: HPO:HP:0004334
database_cross_reference: ICD10:L90
database_cross_reference: ICD10:L90.9
database_cross_reference: ICD10AM:L90
database_cross_reference: ICD10AM:L90.9
database_cross_reference: ICD10CM:L90
database_cross_reference: ICD10CM:L90.9
database_cross_reference: MDR:10003719
database_cross_reference: MDR:10040799
database_cross_reference: MEDCIN:336114
database_cross_reference: MEDCIN:34390
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:701.9
database_cross_reference: NCI:C35163
database_cross_reference: NCI_CTCAE:E13714
database_cross_reference: NCI_NICHD:C35163
database_cross_reference: OMIM:MTHU000149
database_cross_reference: OMIM:MTHU002045
database_cross_reference: RCD:M21z0
database_cross_reference: RCD:X50CH
database_cross_reference: SNMI:D0-40010
database_cross_reference: SNOMEDCT_US:156391001
database_cross_reference: SNOMEDCT_US:16343004
database_cross_reference: SNOMEDCT_US:201090001
database_cross_reference: SNOMEDCT_US:267857003
database_cross_reference: SNOMEDCT_US:399979006
database_cross_reference: SNOMEDCT_US:400190005

Gilbert syndrome
type: Class
subclass of: bilirubin metabolic disorder
definition: A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity.
PMOID: PMO:00028997
Subclass_of: bilirubin metabolic disorder
Synonym: Arias Type Hyperbilirubinemia
Synonym: Arias Type Hyperbilirubinemias
Synonym: Benign unconjugated bilirubinaemia syndrome
Synonym: Benign unconjugated bilirubinemia syndrome
Synonym: Cholaemia familiaris simplex
Synonym: Cholemia familiaris simplex
Synonym: Chronic intermittent juvenile jaundice
Synonym: Congenital familial cholaemia
Synonym: Congenital familial cholemia
Synonym: Constitutional Liver Dysfunction
Tree Number: T10.6.2.3.1
database_cross_reference: CCPSS:0055962
database_cross_reference: CHV:0000005493
database_cross_reference: COSTAR:U000325
database_cross_reference: CSP:1654-1020
database_cross_reference: DO:DOID:2739
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000711
database_cross_reference: ICD10:E80.4
database_cross_reference: ICD10AM:E80.4
database_cross_reference: ICD10CM:E80.4
database_cross_reference: ICPC2P:T99013
database_cross_reference: MDR:10018267
database_cross_reference: MEDCIN:273601
database_cross_reference: MEDCIN:30164
database_cross_reference: MEDLINEPLUS:310
database_cross_reference: MSH:D005878
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.4
database_cross_reference: NCI:C84729
database_cross_reference: NDFRT:N0000001333
database_cross_reference: OMIM:143500
database_cross_reference: OMIM:191740
database_cross_reference: OMIM:MTHU031877
database_cross_reference: RCD:C3742
database_cross_reference: SNM:D-1501
database_cross_reference: SNM:D-1503
database_cross_reference: SNMI:D6-85100
database_cross_reference: SNOMEDCT_US:154770008
database_cross_reference: SNOMEDCT_US:267509000
database_cross_reference: SNOMEDCT_US:27503000

bilirubin metabolic disorder
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism.
PMOID: PMO:00028996
Subclass_of: inherited metabolic disorder
Synonym: BILIRUBINAEMIA
Synonym: BILIRUBINEMIA
Synonym: Bilirubinaemia
Synonym: Bilirubinemia
Synonym: Bilirubinemia, NOS
Synonym: Bilirubinemias
Synonym: Disorder characterized by elevated serum bilirubin
Synonym: HYPERBILIRUBINEMIA
Synonym: High blood bilirubin levels
Synonym: Hyper bilirubinaemia
Tree Number: T10.6.2.3
database_cross_reference: AOD:0000005794
database_cross_reference: CHV:0000006402
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1653-7010
database_cross_reference: CST:BILIRUBINEM
database_cross_reference: DO:DOID:2741
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0002904
database_cross_reference: LCH:U002301
database_cross_reference: LCH_NW:sh85063672
database_cross_reference: MDR:10004702
database_cross_reference: MDR:10004705
database_cross_reference: MDR:10020551
database_cross_reference: MDR:10020578
database_cross_reference: MDR:10020582
database_cross_reference: MEDCIN:273599
database_cross_reference: MSH:D006932
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000255
database_cross_reference: MTH:U000288
database_cross_reference: MTH:U000343
database_cross_reference: MTH:U000372
database_cross_reference: NDFRT:N0000001575
database_cross_reference: RCD:44E2.
database_cross_reference: RCD:X307e
database_cross_reference: RCDAE:X307e
database_cross_reference: SNM:F-15003
database_cross_reference: SNMI:D6-84005
database_cross_reference: SNMI:D6-84380
database_cross_reference: SNOMEDCT_US:143932000
database_cross_reference: SNOMEDCT_US:14783006
database_cross_reference: SNOMEDCT_US:154770008
database_cross_reference: SNOMEDCT_US:166612004
database_cross_reference: SNOMEDCT_US:20505009
database_cross_reference: SNOMEDCT_US:235904007
database_cross_reference: SNOMEDCT_US:267509000
database_cross_reference: SNOMEDCT_VET:14783006
database_cross_reference: SNOMEDCT_VET:166612004

auditory system disease
type: Class
subclass of: sensory system disease
PMOID: PMO:00031378
Subclass_of: sensory system disease
Synonym: A-90 DISEASES OF THE EAR: GENERAL TERMS
Synonym: DISEASES OF THE EAR
Synonym: DISEASES OF THE EAR: GENERAL TERMS
Synonym: DISORDER EAR
Synonym: Disease or syndrome of ear
Synonym: Disease, Ear
Synonym: Disease, Otologic
Synonym: Disease, Otological
Synonym: Disease;ear
Synonym: Diseases, Ear
Tree Number: T10.8.2.11.2
database_cross_reference: AOD:0000006079
database_cross_reference: CHV:0000004228
database_cross_reference: CHV:0000049087
database_cross_reference: CSP:0977-5187
database_cross_reference: CST:EAR DIS
database_cross_reference: CST:GENEAR
database_cross_reference: CST:SS/EAR
database_cross_reference: DO:DOID:2742
database_cross_reference: ICD10:H93.9
database_cross_reference: ICD10AM:H93.9
database_cross_reference: ICD10CM:H93.9
database_cross_reference: ICD10CM:H93.90
database_cross_reference: ICD9CM:388.9
database_cross_reference: ICPC2P:H99005
database_cross_reference: LCH_NW:sh85040387
database_cross_reference: MDR:10013214
database_cross_reference: MDR:10014004
database_cross_reference: MDR:10014005
database_cross_reference: MDR:10045780
database_cross_reference: MDR:10048505
database_cross_reference: MEDCIN:95276
database_cross_reference: MEDLINEPLUS:1545
database_cross_reference: MSH:D004427
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26757
database_cross_reference: NDFRT:N0000001036
database_cross_reference: PSY:15740
database_cross_reference: RCD:F58z.
database_cross_reference: SNM:D-X510
database_cross_reference: SNMI:DA-90000
database_cross_reference: SNOMEDCT_US:155253008
database_cross_reference: SNOMEDCT_US:155261003
database_cross_reference: SNOMEDCT_US:194193002
database_cross_reference: SNOMEDCT_US:194410006
database_cross_reference: SNOMEDCT_US:25906001
database_cross_reference: SNOMEDCT_US:267768008

pyelitis
type: Class
subclass of: kidney disease
PMOID: PMO:00033048
Subclass_of: kidney disease
Synonym: Pyelitis
Synonym: Pyelitis (disorder)
Synonym: Pyelitis NOS
Synonym: Pyelitis [Disease/Finding]
Synonym: Pyelitis unspecified
Synonym: Pyelitis unspecified (disorder)
Synonym: Pyelitis, NOS
Synonym: pyelitis (diagnosis)
Tree Number: T10.8.7.9.17
database_cross_reference: CHV:0000010429
database_cross_reference: DO:DOID:2744
database_cross_reference: ICD10CM:N12
database_cross_reference: ICPC2P:U70002
database_cross_reference: MDR:10037584
database_cross_reference: MEDCIN:276650
database_cross_reference: MSH:D011702
database_cross_reference: MTHICD9:590.80
database_cross_reference: NCI:C34964
database_cross_reference: NDFRT:N0000002558
database_cross_reference: RCD:K10y1
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D7-12610
database_cross_reference: SNOMEDCT_US:197780007
database_cross_reference: SNOMEDCT_US:27174002

narcissistic personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that involves an excessive preoccupation with issues of personal adequacy, power, prestige and vanity.
PMOID: PMO:00027903
Subclass_of: personality disorder
Synonym: NARCISSISTIC PERSONALITY DIS
Synonym: Narcissistic Personality Disorder
Synonym: Narcissistic personal disorder
Synonym: Narcissistic personality
Synonym: Narcissistic personality disorder
Synonym: Narcissistic personality disorder (disorder)
Synonym: PERSONALITY DISORDER NARCISSISTIC
Synonym: Personality Disorder, Narcissistic
Synonym: [X]Narcissistic personality disorder
Synonym: narcissistic personalities
Tree Number: T10.3.2.5
database_cross_reference: AOD:0000006686
database_cross_reference: CCPSS:0044508
database_cross_reference: CHV:0000008485
database_cross_reference: DO:DOID:2745
database_cross_reference: DSM-5:301.81
database_cross_reference: DSM-5:F60.81
database_cross_reference: ICD10CM:F60.81
database_cross_reference: ICD9CM:301.81
database_cross_reference: MDR:10028711
database_cross_reference: MDR:10028712
database_cross_reference: MEDCIN:32851
database_cross_reference: MSH:D010554
database_cross_reference: NCI:C92635
database_cross_reference: PSY:32960
database_cross_reference: RCD:E21y0
database_cross_reference: SNM:F-936X0
database_cross_reference: SNMI:D9-62400
database_cross_reference: SNOMEDCT_US:192493008
database_cross_reference: SNOMEDCT_US:80711002

Mycobacterium avium complex disease
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons.
PMOID: PMO:00029528
Subclass_of: primary bacterial infectious disease
Synonym: INFECT MYCOBACT AVIUM INTRACELLULARE
Synonym: INFECT MYCOBACT INTRACELLULARE
Synonym: Infection caused by Mycobacterium intracellulare
Synonym: Infection caused by Mycobacterium intracellulare (disorder)
Synonym: Infection due to Mycobacterium intracellulare
Synonym: Infection due to Mycobacterium intracellulare (disorder)
Synonym: Infection mycobacterium avium
Synonym: Infection, Mycobacterium avium intracellulare
Synonym: Infection, Mycobacterium avium-intracellulare
Synonym: Infection, Mycobacterium intracellulare
Tree Number: T10.7.3.1.23
database_cross_reference: CCPSS:0046810
database_cross_reference: CSP:0322-0521
database_cross_reference: DO:DOID:2755
database_cross_reference: DXP:U002696
database_cross_reference: MDR:10021840
database_cross_reference: MDR:10025372
database_cross_reference: MDR:10028443
database_cross_reference: MDR:10028445
database_cross_reference: MDR:10058806
database_cross_reference: MDR:10058807
database_cross_reference: MEDCIN:98009
database_cross_reference: MSH:D015270
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C36197
database_cross_reference: NDFRT:N0000003215
database_cross_reference: SNM:D-0147
database_cross_reference: SNMI:DE-12912
database_cross_reference: SNOMEDCT_US:14009004
database_cross_reference: SNOMEDCT_US:373436002

tic disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.
PMOID: PMO:00028002
Subclass_of: specific developmental disorder
Synonym: 9-15 TIC DISORDERS
Synonym: TIC
Synonym: TIC DIS
Synonym: TIC DISORDER
Synonym: TIC DISORDERS
Synonym: TICS
Synonym: Tic
Synonym: Tic (finding)
Synonym: Tic Disorder
Synonym: Tic Disorders
Tree Number: T10.3.5.1.8
database_cross_reference: AOD:0000000042
database_cross_reference: CCPSS:0019059
database_cross_reference: CHV:0000012279
database_cross_reference: CST:TWITCH
database_cross_reference: DO:DOID:2769
database_cross_reference: DSM-5:307.20
database_cross_reference: DSM-5:F95.9
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U004028
database_cross_reference: ICD10:F95
database_cross_reference: ICD10:F95.9
database_cross_reference: ICD10AM:F95
database_cross_reference: ICD10AM:F95.9
database_cross_reference: ICD10CM:F95
database_cross_reference: ICD10CM:F95.9
database_cross_reference: ICD9CM:307.2
database_cross_reference: ICD9CM:307.20
database_cross_reference: LCH:U004694
database_cross_reference: LCH_NW:sh85135241
database_cross_reference: MDR:10043833
database_cross_reference: MDR:10043834
database_cross_reference: MDR:10043835
database_cross_reference: MDR:10043849
database_cross_reference: MEDCIN:273151
database_cross_reference: MSH:D013981
database_cross_reference: MTH:U002310
database_cross_reference: MTHICD9:307.20
database_cross_reference: NDFRT:N0000002950
database_cross_reference: PSY:53200
database_cross_reference: RCD:E272.
database_cross_reference: RCD:E2720
database_cross_reference: RCD:E272z
database_cross_reference: RCD:Eu95.
database_cross_reference: RCD:Xa9BB
database_cross_reference: RCDSY:Eu95.
database_cross_reference: SNM:F-84570
database_cross_reference: SNMI:D9-15000
database_cross_reference: SNMI:F-93450
database_cross_reference: SNOMEDCT_US:112086008
database_cross_reference: SNOMEDCT_US:155005001
database_cross_reference: SNOMEDCT_US:191988002
database_cross_reference: SNOMEDCT_US:191989005
database_cross_reference: SNOMEDCT_US:191991002
database_cross_reference: SNOMEDCT_US:192621007
database_cross_reference: SNOMEDCT_US:192626002
database_cross_reference: SNOMEDCT_US:35042001
database_cross_reference: SNOMEDCT_US:386783003
database_cross_reference: SNOMEDCT_US:393585001
database_cross_reference: SNOMEDCT_US:568005

parasitic protozoa infectious disease
type: Class
subclass of: parasitic infectious disease
definition: A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.
PMOID: PMO:00029678
Subclass_of: parasitic infectious disease
Synonym: INFECT PROTOZOAN
Synonym: INFECTION PROTOZOAL
Synonym: Infection protozoal
Synonym: Infection, Protozoan
Synonym: Infections, Protozoan
Synonym: PROTOZOAL INFECTIOUS DISEASES
Synonym: PROTOZOAN INFECT
Synonym: Protozoal Infection
Synonym: Protozoal disease
Synonym: Protozoal disease (disorder)
Tree Number: T10.7.4.2
database_cross_reference: AOD:0000004883
database_cross_reference: CHV:0000010266
database_cross_reference: CSP:2214-4651
database_cross_reference: CST:INFECT
database_cross_reference: DO:DOID:2789
database_cross_reference: ICD10:B50-B64.9
database_cross_reference: ICD10:B64
database_cross_reference: ICD10AM:B50-B64.9
database_cross_reference: ICD10AM:B64
database_cross_reference: ICD10CM:B50-B64
database_cross_reference: ICD10CM:B64
database_cross_reference: MDR:10021859
database_cross_reference: MDR:10037072
database_cross_reference: MDR:10037073
database_cross_reference: MEDCIN:318460
database_cross_reference: MSH:D011528
database_cross_reference: NCI:C34953
database_cross_reference: NCI_NICHD:C34953
database_cross_reference: NDFRT:N0000002508
database_cross_reference: RCD:AyuF.
database_cross_reference: RCD:AyuFE
database_cross_reference: RCD:X70OW
database_cross_reference: RCDSY:AyuF.
database_cross_reference: RCDSY:AyuFE
database_cross_reference: SNMI:DE-50000
database_cross_reference: SNMI:DE-50090
database_cross_reference: SNOMEDCT_US:187247003
database_cross_reference: SNOMEDCT_US:187502000
database_cross_reference: SNOMEDCT_US:187517001
database_cross_reference: SNOMEDCT_US:240627001
database_cross_reference: SNOMEDCT_US:367372008
database_cross_reference: SNOMEDCT_US:89933001
database_cross_reference: SNOMEDCT_US:95896000

necatoriasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.
PMOID: PMO:00029648
Subclass_of: parasitic helminthiasis infectious disease
Synonym: NECATORIASIS
Synonym: Necatoriases
Synonym: Necatoriasis
Synonym: Necatoriasis (disorder)
Synonym: Necatoriasis [Disease/Finding]
Synonym: Necatorosis
Tree Number: T10.7.4.1.26
database_cross_reference: DO:DOID:2790
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:B76.1
database_cross_reference: ICD10AM:B76.1
database_cross_reference: ICD10CM:B76.1
database_cross_reference: MSH:D009332
database_cross_reference: NCI:C34838
database_cross_reference: NDFRT:N0000002115
database_cross_reference: SNMI:DE-67020
database_cross_reference: SNOMEDCT_US:36667009

endocrine system disease
type: Class
subclass of: disease of anatomical entity
definition: A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.
PMOID: PMO:00033106
Subclass_of: disease of anatomical entity
Synonym: CHAPTER B DISEASES OF THE ENDOCRINE SYSTEM
Synonym: DIS ENDOCRINE SYSTEM
Synonym: DISEASES OF THE ENDOCRINE SYSTEM
Synonym: DISORDER ENDOCRINE
Synonym: Disease of endocrine gland
Synonym: Disease of endocrine gland (disorder)
Synonym: Disease of endocrine glands, NOS
Synonym: Disease, Endocrine
Synonym: Disease, Endocrine System
Synonym: Diseases of Endocrine System
Tree Number: T10.8.8
database_cross_reference: AOD:0000005967
database_cross_reference: CCPSS:0057756
database_cross_reference: CHV:0000004447
database_cross_reference: COSTAR:U000022
database_cross_reference: COSTAR:U000231
database_cross_reference: COSTAR:U000232
database_cross_reference: CSP:1025-5693
database_cross_reference: CST:ENDO
database_cross_reference: CST:ENDO DIS
database_cross_reference: DO:DOID:28
database_cross_reference: HPO:HP:0000818
database_cross_reference: ICD10:E34.9
database_cross_reference: ICD10AM:E34.9
database_cross_reference: ICD10CM:E34.9
database_cross_reference: ICD9CM:259.9
database_cross_reference: ICPC2P:T99059
database_cross_reference: LCH_NW:sh85043061
database_cross_reference: LNC:LP56737-7
database_cross_reference: LNC:MTHU021570
database_cross_reference: MDR:10013217
database_cross_reference: MDR:10014695
database_cross_reference: MDR:10014697
database_cross_reference: MDR:10014698
database_cross_reference: MDR:10045863
database_cross_reference: MDR:10048509
database_cross_reference: MEDCIN:38672
database_cross_reference: MEDLINEPLUS:475
database_cross_reference: MSH:D004700
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:259.9
database_cross_reference: NCI:C3009
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NICHD:C3009
database_cross_reference: NDFRT:N0000001099
database_cross_reference: PSY:17300
database_cross_reference: RCD:C1zz.
database_cross_reference: RCD:X40Gd
database_cross_reference: RCD:XE12O
database_cross_reference: RCD:XE12q
database_cross_reference: SNM:D-2000
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DB-00000
database_cross_reference: SNOMEDCT_US:118639003
database_cross_reference: SNOMEDCT_US:127345001
database_cross_reference: SNOMEDCT_US:154648001
database_cross_reference: SNOMEDCT_US:154690007
database_cross_reference: SNOMEDCT_US:154718007
database_cross_reference: SNOMEDCT_US:190231001
database_cross_reference: SNOMEDCT_US:190594008
database_cross_reference: SNOMEDCT_US:267462005
database_cross_reference: SNOMEDCT_US:267475005
database_cross_reference: SNOMEDCT_US:267489000
database_cross_reference: SNOMEDCT_US:362969004
database_cross_reference: SNOMEDCT_US:67432001

nose disease
type: Class
subclass of: upper respiratory tract disease
PMOID: PMO:00032457
Subclass_of: upper respiratory tract disease
Synonym: Disease of the nose
Synonym: Disease of the nose (disorder)
Synonym: Disease of the nose, NOS
Synonym: Disease or syndrome of nose
Synonym: Disease, Nasal
Synonym: Disease, Nose
Synonym: Diseases, Nasal
Synonym: Diseases, Nose
Synonym: Disorder of the nose
Synonym: Disorder of the nose (disorder)
Tree Number: T10.8.5.2.1
database_cross_reference: AOD:0000005438
database_cross_reference: CHV:0000008787
database_cross_reference: CSP:1997-0936
database_cross_reference: CST:RES/NOSE
database_cross_reference: DO:DOID:2825
database_cross_reference: DRUGBANK:DB00388
database_cross_reference: DRUGBANK:DB10672
database_cross_reference: LCH_NW:sh85092750
database_cross_reference: MDR:10052355
database_cross_reference: MDR:10062209
database_cross_reference: MEDCIN:95277
database_cross_reference: MEDLINEPLUS:1400
database_cross_reference: MSH:D009668
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002194
database_cross_reference: SNM:D-X620
database_cross_reference: SNMI:D2-02000
database_cross_reference: SNOMEDCT_US:89488007

bruxism
type: Class
subclass of: sleep disorder
definition: A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.
PMOID: PMO:00027883
Subclass_of: sleep disorder
Synonym: BRUXISM
Synonym: Bruxism
Synonym: Bruxism (grinding teeth)
Synonym: Bruxism (teeth grinding)
Synonym: Bruxism (teeth grinding) (disorder)
Synonym: Bruxism - teeth grinding
Synonym: Bruxism [Disease/Finding]
Synonym: Bruxomania
Synonym: Disorder, Teeth Grinding
Synonym: Disorders, Teeth Grinding
Tree Number: T10.3.1.1
database_cross_reference: AOD:0000006725
database_cross_reference: AOD:0000024014
database_cross_reference: CHV:0000002208
database_cross_reference: COSTAR:U000093
database_cross_reference: CSP:0840-0405
database_cross_reference: CST:NEUROSIS
database_cross_reference: CST:TOOTH DIS
database_cross_reference: DO:DOID:2846
database_cross_reference: HPO:HP:0003763
database_cross_reference: ICD10CM:F45.8
database_cross_reference: ICPC2P:D29002
database_cross_reference: LCH:U000701
database_cross_reference: LCH_NW:sh85017369
database_cross_reference: MDR:10006514
database_cross_reference: MDR:10006515
database_cross_reference: MDR:10018489
database_cross_reference: MDR:10018725
database_cross_reference: MDR:10043175
database_cross_reference: MDR:10043176
database_cross_reference: MDR:10043182
database_cross_reference: MEDCIN:11205
database_cross_reference: MEDCIN:1559
database_cross_reference: MEDCIN:273150
database_cross_reference: MEDLINEPLUS:3069
database_cross_reference: MSH:D002012
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:306.8
database_cross_reference: NCI:C73511
database_cross_reference: NCI_NICHD:C73511
database_cross_reference: NDFRT:N0000000629
database_cross_reference: OMIM:MTHU006931
database_cross_reference: OMIM:MTHU044389
database_cross_reference: PSY:07035
database_cross_reference: PSY:51830
database_cross_reference: RCD:E26y0
database_cross_reference: RCD:X763t
database_cross_reference: SNM:F-91270
database_cross_reference: SNMI:F-93472
database_cross_reference: SNOMEDCT_US:154925009
database_cross_reference: SNOMEDCT_US:191983006
database_cross_reference: SNOMEDCT_US:192436003
database_cross_reference: SNOMEDCT_US:268774006
database_cross_reference: SNOMEDCT_US:367105000
database_cross_reference: SNOMEDCT_US:90207007

hyperthyroxinemia
type: Class
subclass of: thyroid gland disease
PMOID: PMO:00033158
Subclass_of: thyroid gland disease
Synonym: Hyperthyroxinemia
Synonym: Hyperthyroxinemia [Disease/Finding]
Synonym: Hyperthyroxinemias
Tree Number: T10.8.8.3.2
database_cross_reference: CHV:0000006452
database_cross_reference: DO:DOID:2855
database_cross_reference: MSH:D006981
database_cross_reference: MTH:U000338
database_cross_reference: NDFRT:N0000001623

euthyroid sick syndrome
type: Class
subclass of: thyroid gland disease
PMOID: PMO:00033193
Subclass_of: thyroid gland disease
Synonym: Euthyroid Sick Syndrome
Synonym: Euthyroid Sick Syndromes
Synonym: Euthyroid Sick Syndromes [Disease/Finding]
Synonym: Euthyroid sick syndrome
Synonym: Euthyroid sick-syndrome
Synonym: Non Thyroidal Illness Syndrome
Synonym: Non-Thyroidal Illness Syndrome
Synonym: SICK EUTHYROID SYNDROME
Synonym: Sick Euthyroid Syndrome
Synonym: Sick euthyroid syndrome
Tree Number: T10.8.8.3.10
database_cross_reference: CCPSS:0019878
database_cross_reference: CHV:0000004743
database_cross_reference: DO:DOID:2856
database_cross_reference: ICD10CM:E07.81
database_cross_reference: ICD9CM:790.94
database_cross_reference: MDR:10015549
database_cross_reference: MEDCIN:180718
database_cross_reference: MSH:D005067
database_cross_reference: NCI:C113170
database_cross_reference: NCI_NICHD:C113170
database_cross_reference: NDFRT:N0000001169
database_cross_reference: RCD:X40Hi
database_cross_reference: SNOMEDCT_US:237542005

glucosephosphate dehydrogenase deficiency
type: Class
subclass of: carbohydrate metabolic disorder
definition: A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH).
PMOID: PMO:00029120
Subclass_of: carbohydrate metabolic disorder
Synonym: DEFIC GLUCOSEPHOSPHATE DEHYDROGENASE
Synonym: DEFIC GPD
Synonym: Deficiencies, G6PD
Synonym: Deficiencies, GPD
Synonym: Deficiencies, Glucose-6-Phosphate Dehydrogenase
Synonym: Deficiencies, Glucosephosphate Dehydrogenase
Synonym: Deficiency of G-6PD
Synonym: Deficiency of Glucose 6 Phosphate Dehydrogenase
Synonym: Deficiency of Glucose-6-Phosphate Dehydrogenase
Synonym: Deficiency of glucose-6-phosphate dehydrogenase
Tree Number: T10.6.2.11.2
database_cross_reference: AOD:0000023543
database_cross_reference: CCPSS:0033767
database_cross_reference: CHV:0000005572
database_cross_reference: COSTAR:U000310
database_cross_reference: CSP:1849-3722
database_cross_reference: DO:DOID:2862
database_cross_reference: ICPC2P:T99042
database_cross_reference: LCH:U001992
database_cross_reference: LCH_NW:sh85055364
database_cross_reference: LNC:LA12540-3
database_cross_reference: MDR:10017567
database_cross_reference: MDR:10018443
database_cross_reference: MDR:10018444
database_cross_reference: MDR:10075677
database_cross_reference: MEDCIN:358388
database_cross_reference: MEDLINEPLUS:6155
database_cross_reference: MSH:D005955
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98933
database_cross_reference: NCI_NICHD:C98933
database_cross_reference: NDFRT:N0000001360
database_cross_reference: RCD:X20DE
database_cross_reference: SNOMEDCT_US:124134002
database_cross_reference: SNOMEDCT_US:154738008
database_cross_reference: SNOMEDCT_US:267498002
database_cross_reference: SNOMEDCT_US:62403005

endometriosis
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.
PMOID: PMO:00029790
Subclass_of: female reproductive system disease
Synonym: 765 ENDOMETRIOSES
Synonym: ENDOMETRIOSES
Synonym: ENDOMETRIOSIS
Synonym: Endo
Synonym: Endometrioses
Synonym: Endometriosis
Synonym: Endometriosis (clinical)
Synonym: Endometriosis (disorder)
Synonym: Endometriosis (morphologic abnormality)
Synonym: Endometriosis -RETIRED-
Tree Number: T10.8.1.4.2
database_cross_reference: BI:BI00384
database_cross_reference: CCPSS:1007688
database_cross_reference: CHV:0000004463
database_cross_reference: COSTAR:279
database_cross_reference: CSP:2000-5488
database_cross_reference: CST:ENDOMETR DIS
database_cross_reference: DO:DOID:289
database_cross_reference: DXP:U000553
database_cross_reference: DXP:U001121
database_cross_reference: HPO:HP:0030127
database_cross_reference: ICD10:N80
database_cross_reference: ICD10:N80.9
database_cross_reference: ICD10AM:N80
database_cross_reference: ICD10AM:N80.9
database_cross_reference: ICD10CM:N80
database_cross_reference: ICD10CM:N80.9
database_cross_reference: ICD9CM:617
database_cross_reference: ICD9CM:617.9
database_cross_reference: ICPC2P:X99016
database_cross_reference: LCH:U001584
database_cross_reference: LCH_NW:sh85043079
database_cross_reference: MDR:10014778
database_cross_reference: MDR:10014789
database_cross_reference: MEDCIN:30610
database_cross_reference: MEDLINEPLUS:243
database_cross_reference: MSH:D004715
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3014
database_cross_reference: NCI_NCI-GLOSS:CDR0000046427
database_cross_reference: NDFRT:N0000001102
database_cross_reference: OMIM:MTHU036719
database_cross_reference: RCD:K50z.
database_cross_reference: RCD:XE0eW
database_cross_reference: SNM:M-76500
database_cross_reference: SNM:U000382
database_cross_reference: SNMI:M-76500
database_cross_reference: SNOMEDCT_US:103677003
database_cross_reference: SNOMEDCT_US:11871002
database_cross_reference: SNOMEDCT_US:129103003
database_cross_reference: SNOMEDCT_US:155988000
database_cross_reference: SNOMEDCT_US:198246007
database_cross_reference: SNOMEDCT_US:198259004
database_cross_reference: SNOMEDCT_US:266588002
database_cross_reference: SNOMEDCT_US:396224008

Goldenhar syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.
PMOID: PMO:00025169
Subclass_of: syndrome
Synonym: Craniofacial Microsomia
Synonym: Craniofacial Microsomias
Synonym: Craniofacial microsomia
Synonym: Craniofacial microsomia (disorder)
Synonym: Disease, Goldenhar
Synonym: Dysostoses, Otomandibular
Synonym: Dysostosis, Otomandibular
Synonym: Dysplasia, Facioauriculovertebral
Synonym: Dysplasia, Lateral Facial
Synonym: Dysplasia, Oculoauriculovertebral
Tree Number: T10.1.50
database_cross_reference: CHV:0000025862
database_cross_reference: CSP:0725-7823
database_cross_reference: DO:DOID:2907
database_cross_reference: ICD10CM:Q87.0
database_cross_reference: JABL:492
database_cross_reference: MDR:10050349
database_cross_reference: MDR:10051934
database_cross_reference: MEDCIN:312432
database_cross_reference: MSH:D006053
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84740
database_cross_reference: NCI_NICHD:C84740
database_cross_reference: NDFRT:N0000001375
database_cross_reference: OMIM:164210
database_cross_reference: RCD:PG0F.
database_cross_reference: RCD:X7894
database_cross_reference: SNM:D-5101
database_cross_reference: SNM:D-5104
database_cross_reference: SNMI:D4-00720
database_cross_reference: SNMI:D4-01301
database_cross_reference: SNOMEDCT_US:109393007
database_cross_reference: SNOMEDCT_US:15557005
database_cross_reference: SNOMEDCT_US:205418005
database_cross_reference: SNOMEDCT_US:254025006
database_cross_reference: SNOMEDCT_US:254026007
database_cross_reference: SNOMEDCT_US:367462009
database_cross_reference: SNOMEDCT_US:46567003
database_cross_reference: SNOMEDCT_US:703973009

immune system disease
type: Class
subclass of: disease of anatomical entity
PMOID: PMO:00032615
Subclass_of: disease of anatomical entity
Synonym: C-50 DISEASES OF THE IMMUNE SYSTEM: GENERAL TERMS
Synonym: DIS IMMUNE SYSTEM
Synonym: DISEASES OF THE IMMUNE SYSTEM
Synonym: DISEASES OF THE IMMUNE SYSTEM: GENERAL TERMS
Synonym: DISORDER IMMUNE SYSTEM (NOS)
Synonym: Disease of immune system
Synonym: Disease of immune system (disorder)
Synonym: Disease of immune system, NOS
Synonym: Disease, Immune
Synonym: Disease, Immune System
Tree Number: T10.8.6
database_cross_reference: AOD:0000005947
database_cross_reference: CHV:0000006604
database_cross_reference: CSP:1560-4280
database_cross_reference: CST:IMMUNE SYSTEM DIS
database_cross_reference: ICD10CM:D89.9
database_cross_reference: LCH:U002386
database_cross_reference: LCH_NW:sh85064571
database_cross_reference: MDR:10013229
database_cross_reference: MDR:10021418
database_cross_reference: MDR:10021425
database_cross_reference: MDR:10021426
database_cross_reference: MDR:10021427
database_cross_reference: MDR:10021428
database_cross_reference: MEDCIN:38676
database_cross_reference: MEDLINEPLUS:295
database_cross_reference: MSH:D007154
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3507
database_cross_reference: NCI_CTEP-SDC:10021425
database_cross_reference: NCI_NICHD:C3507
database_cross_reference: NDFRT:N0000001668
database_cross_reference: OMIM:MTHU056565
database_cross_reference: PSY:24590
database_cross_reference: RCD:C39..
database_cross_reference: SNM:U000013
database_cross_reference: SNMI:DC-50000
database_cross_reference: SNOMEDCT_US:154779009
database_cross_reference: SNOMEDCT_US:154780007
database_cross_reference: SNOMEDCT_US:41266007

hypersensitivity reaction type IV disease
type: Class
subclass of: hypersensitivity reaction disease
PMOID: PMO:00032710
Subclass_of: hypersensitivity reaction disease
Synonym: 976 IMMUNOPROLIFERATIVE DISEASES
Synonym: Disorder, Immunoproliferative
Synonym: Disorders, Immunoproliferative
Synonym: IMMUNOPROLIFERATIVE DIS
Synonym: IMMUNOPROLIFERATIVE DISEASES
Synonym: Immunoproliferative Diseases
Synonym: Immunoproliferative Disorder
Synonym: Immunoproliferative Disorders
Synonym: Immunoproliferative Disorders [Disease/Finding]
Synonym: Immunoproliferative disease
Tree Number: T10.8.6.3.3
database_cross_reference: CHV:0000006610
database_cross_reference: DO:DOID:2916
database_cross_reference: ICD10AM:M9760/3
database_cross_reference: ICD10CM:C88.9
database_cross_reference: MSH:D007160
database_cross_reference: NDFRT:N0000001669
database_cross_reference: SNM:D-4850
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:M-97600
database_cross_reference: SNMI:M-97603
database_cross_reference: SNOMEDCT_US:127071007
database_cross_reference: SNOMEDCT_US:134363002
database_cross_reference: SNOMEDCT_US:86295000

Klippel-Trenaunay syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues.
PMOID: PMO:00025162
Subclass_of: syndrome
Synonym: ANGIOOSTEOHYPERTROPHY SYNDROME
Synonym: Angio Osteohypertrophy Syndrome
Synonym: Angio-Osteohypertrophy Syndrome
Synonym: Angio-Osteohypertrophy Syndromes
Synonym: Angio-osteohypertrophy syndrome
Synonym: Angioosteohypertrophic syndrome
Synonym: Angioosteohypertrophy Syndrome
Synonym: Angioosteohypertrophy Syndromes
Synonym: Angiopathies, Congenital Dysplastic
Synonym: Angiopathy, Congenital Dysplastic
Tree Number: T10.1.43
database_cross_reference: CHV:0000007123
database_cross_reference: DO:DOID:2926
database_cross_reference: ICD10CM:Q87.2
database_cross_reference: JABL:387
database_cross_reference: MDR:10051452
database_cross_reference: MDR:10056915
database_cross_reference: MEDCIN:33298
database_cross_reference: MSH:D007715
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84801
database_cross_reference: NCI_NICHD:C84801
database_cross_reference: NDFRT:N0000001761
database_cross_reference: OMIM:149000
database_cross_reference: RCD:PKy72
database_cross_reference: SNM:D-5414
database_cross_reference: SNMI:D4-01025
database_cross_reference: SNOMEDCT_US:59078009
database_cross_reference: SNOMEDCT_US:721105004

Newcastle disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.
PMOID: PMO:00029440
Subclass_of: viral infectious disease
Synonym: Avian pneumoencephalitis
Synonym: Disease, Newcastle
Synonym: NEWCASTLE DIS
Synonym: NEWCASTLE DISEASE
Synonym: Newcastle Disease
Synonym: Newcastle Disease [Disease/Finding]
Synonym: Newcastle disease (diagnosis)
Synonym: Newcastle disease (disorder)
Synonym: Newcastle disease [Ambiguous]
Synonym: Newcastle fever
Tree Number: T10.7.2.71
database_cross_reference: CHV:0000008694
database_cross_reference: DO:DOID:2929
database_cross_reference: DXP:U001296
database_cross_reference: LCH:U003222
database_cross_reference: LCH_NW:sh85091545
database_cross_reference: MDR:10029393
database_cross_reference: MEDCIN:31009
database_cross_reference: MSH:D009521
database_cross_reference: NCI:C34849
database_cross_reference: NDFRT:N0000002186
database_cross_reference: RCD:X00Zp
database_cross_reference: SNM:D-0438
database_cross_reference: SNMI:DE-33750
database_cross_reference: SNOMEDCT_US:155162002
database_cross_reference: SNOMEDCT_US:231859001
database_cross_reference: SNOMEDCT_US:258300000
database_cross_reference: SNOMEDCT_US:267734002
database_cross_reference: SNOMEDCT_US:89366008
database_cross_reference: SNOMEDCT_VET:352271000009105

aleutian mink disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.
PMOID: PMO:00029422
Subclass_of: viral infectious disease
Synonym: Aleutian disease
Tree Number: T10.7.2.56
database_cross_reference: DO:DOID:2934

severe acute respiratory syndrome
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.
PMOID: PMO:00029398
Subclass_of: viral infectious disease
Synonym: Coronavirus Infections
Synonym: Respiratory Syndrome, Acute, Severe
Synonym: Respiratory Syndrome, Severe Acute
Synonym: SARS
Synonym: SARS (Severe Acute Respiratory Syndrome)
Synonym: SARS assoc coronavirus
Synonym: SARS-CoV infection
Synonym: SARS-associated coronavirus
Synonym: SARS-associated coronavirus (diagnosis)
Synonym: Severe Acute Respiratory Syndrome
Tree Number: T10.7.2.42
database_cross_reference: CHV:0000055815
database_cross_reference: CSP:5004-0074
database_cross_reference: DO:DOID:2945
database_cross_reference: ICD10CM:J12.81
database_cross_reference: ICD9CM:079.82
database_cross_reference: LNC:LA10504-1
database_cross_reference: LNC:LP71047-2
database_cross_reference: MDR:10061982
database_cross_reference: MDR:10061986
database_cross_reference: MEDCIN:272816
database_cross_reference: MEDCIN:330007
database_cross_reference: MEDLINEPLUS:3181
database_cross_reference: MSH:D045169
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85064
database_cross_reference: NCI_NICHD:C85064
database_cross_reference: NDFRT:N0000010956
database_cross_reference: SNOMEDCT_US:398447004

kidney cortex necrosis
type: Class
subclass of: kidney disease
PMOID: PMO:00033026
Subclass_of: kidney disease
Synonym: Cortical necrosis NOS
Synonym: KIDNEY CORTEX NECROSIS
Synonym: Kidney Cortex Necrosis
Synonym: Kidney Cortex Necrosis [Disease/Finding]
Synonym: Kidney cortex necrosis
Synonym: NECROSIS KIDNEY CORTEX
Synonym: Necrosis kidney cortex
Synonym: Necrosis of cortex of kidney
Synonym: Necrosis of cortex of kidney (disorder)
Synonym: Necrosis of the kidney cortex
Tree Number: T10.8.7.9.10
database_cross_reference: CHV:0000007089
database_cross_reference: CST:NECRO KIDNEY CORTEX
database_cross_reference: DO:DOID:2973
database_cross_reference: HPO:HP:0025418
database_cross_reference: ICD10CM:N17.1
database_cross_reference: MDR:10023414
database_cross_reference: MDR:10028864
database_cross_reference: MDR:10038422
database_cross_reference: MEDCIN:96692
database_cross_reference: MSH:D007673
database_cross_reference: MTHICD9:583.6
database_cross_reference: NDFRT:N0000001747
database_cross_reference: SNM:M-54000
database_cross_reference: SNMI:D7-13150
database_cross_reference: SNOMEDCT_US:444691002
database_cross_reference: SNOMEDCT_US:45456005

cystic kidney disease
type: Class
subclass of: kidney disease
PMOID: PMO:00033075
Subclass_of: kidney disease
Synonym: Cystic Kidney
Synonym: Cystic Kidneys
Synonym: Cystic kidney
Synonym: Cystic kidney disease
Synonym: Cystic kidneys
Synonym: KIDNEY CYST
Synonym: Kidney, Cystic
Synonym: Kidneys, Cystic
Synonym: cystic diseases kidney
Synonym: cystic diseases renal
Tree Number: T10.8.7.9.21
database_cross_reference: CHV:0000007104
database_cross_reference: CSP:1682-0412
database_cross_reference: DO:DOID:2975
database_cross_reference: HPO:HP:0000107
database_cross_reference: LCH:U002583
database_cross_reference: LCH_NW:sh85072247
database_cross_reference: MSH:D052177
database_cross_reference: MTH:646
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU005771
database_cross_reference: OMIM:MTHU011852

primary hyperoxaluria
type: Class
subclass of: carbohydrate metabolic disorder
subclass of: kidney disease
PMOID: PMO:00029126
Subclass_of: carbohydrate metabolic disorder
Subclass_of: kidney disease
Synonym: High urine oxalate levels
Synonym: Hyperoxaluria
Synonym: Hyperoxaluria (disorder)
Synonym: Hyperoxaluria [Disease/Finding]
Synonym: Oxaluria
Synonym: hyperoxaluria
Synonym: hyperoxaluria (diagnosis)
Synonym: oxaluria
Tree Number: T10.6.2.11.5
Tree Number: T10.8.7.9.3
database_cross_reference: CHV:0000006431
database_cross_reference: DO:DOID:2977
database_cross_reference: HPO:HP:0003159
database_cross_reference: ICD10CM:E72.53
database_cross_reference: LCH:U005668
database_cross_reference: LCH_NW:sh85096292
database_cross_reference: MDR:10020703
database_cross_reference: MEDCIN:33593
database_cross_reference: MSH:D006959
database_cross_reference: MTHICD9:271.8
database_cross_reference: NDFRT:N0000001602
database_cross_reference: OMIM:MTHU037859
database_cross_reference: SNOMEDCT_US:367621000119107

carbohydrate metabolic disorder
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates.
PMOID: PMO:00029118
Subclass_of: inherited metabolic disorder
Synonym: CARB METAB INBORN ERR
Synonym: CARBOHYDRATE METAB INBORN ERR
Synonym: Carbohydrate Metabolism, Inborn Error
Synonym: Carbohydrate Metabolism, Inborn Errors
Synonym: Carbohydrate Metabolism, Inborn Errors [Disease/Finding]
Synonym: disorder of carbohydrate transport and metabolism
Synonym: inborn carbohydrate metabolism disorder
Synonym: inborn errors of carbohydrate metabolism
Tree Number: T10.6.2.11
database_cross_reference: CSP:0551-8201
database_cross_reference: DO:DOID:2978
database_cross_reference: MSH:D002239
database_cross_reference: NDFRT:N0000000658

kidney papillary necrosis
type: Class
subclass of: kidney disease
PMOID: PMO:00033023
Subclass_of: kidney disease
Synonym: KIDNEY, PAPILLARY NECROSIS
Synonym: Kidney Papillary Necrosis
Synonym: Kidney Papillary Necrosis [Disease/Finding]
Synonym: Medullary necrosis
Synonym: NECROSIS KIDNEY PAPILLARY
Synonym: NECROSIS PAPILLARY KIDNEY
Synonym: Necrosis kidney papillary
Synonym: Necrosis papillary kidney
Synonym: Necrosis, Kidney Papillary
Synonym: Necrosis, Renal Medullary
Tree Number: T10.8.7.9.7
database_cross_reference: CCPSS:1009688
database_cross_reference: CHV:0000007097
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:NECRO KIDNEY PAPILL
database_cross_reference: DO:DOID:2981
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000985
database_cross_reference: ICPC2P:U99024
database_cross_reference: MDR:10028865
database_cross_reference: MDR:10028876
database_cross_reference: MDR:10033695
database_cross_reference: MDR:10033699
database_cross_reference: MDR:10033711
database_cross_reference: MDR:10038479
database_cross_reference: MDR:10038491
database_cross_reference: MDR:10038493
database_cross_reference: MDR:10038494
database_cross_reference: MDR:10056221
database_cross_reference: MEDCIN:30673
database_cross_reference: MEDCIN:96693
database_cross_reference: MSH:D007681
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:583.7
database_cross_reference: MTHICD9:584.7
database_cross_reference: NDFRT:N0000001752
database_cross_reference: RCD:X30J5
database_cross_reference: RCDAE:X30J5
database_cross_reference: SNM:M-40700
database_cross_reference: SNM:M-54000
database_cross_reference: SNMI:D7-13160
database_cross_reference: SNOMEDCT_US:197651008
database_cross_reference: SNOMEDCT_US:90241004

perinephritis
type: Class
subclass of: kidney disease
PMOID: PMO:00033077
Subclass_of: kidney disease
Synonym: Inflammation, Perinephrium
Synonym: Inflammations, Perinephrium
Synonym: PERINEPHRITIS
Synonym: Perinephritides
Synonym: Perinephritis
Synonym: Perinephritis (disorder)
Synonym: Perinephritis [Disease/Finding]
Synonym: Perinephritis, NOS
Synonym: Perinephrium Inflammation
Tree Number: T10.8.7.9.22
database_cross_reference: DO:DOID:2982
database_cross_reference: DXP:U001459
database_cross_reference: HPO:HP:0012784
database_cross_reference: MDR:10072058
database_cross_reference: MSH:D010501
database_cross_reference: NDFRT:N0000002366
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D7-11770
database_cross_reference: SNOMEDCT_US:111404004

anuria
type: Class
subclass of: kidney disease
PMOID: PMO:00033085
Subclass_of: kidney disease
Synonym: ANURIA
Synonym: Absence of urine volume
Synonym: Absent urine output
Synonym: Anuria
Synonym: Anuria (finding)
Synonym: Anuria [Disease/Finding]
Synonym: Anurias
Synonym: Arrest of urinary output
Synonym: Failure of urine formation
Synonym: Passes no urine
Tree Number: T10.8.7.9.26
database_cross_reference: CCPSS:1009390
database_cross_reference: CHV:0000001337
database_cross_reference: CST:ANURIA
database_cross_reference: DO:DOID:2983
database_cross_reference: DXP:U000207
database_cross_reference: HPO:HP:0100519
database_cross_reference: ICPC2P:U05001
database_cross_reference: LCH:U000313
database_cross_reference: LCH_NW:sh85005820
database_cross_reference: LNC:LA25308-0
database_cross_reference: MDR:10002847
database_cross_reference: MDR:10003113
database_cross_reference: MDR:10016160
database_cross_reference: MDR:10046550
database_cross_reference: MDR:10046641
database_cross_reference: MSH:D001002
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:788.5
database_cross_reference: NCI:C114699
database_cross_reference: NCI_NICHD:C114699
database_cross_reference: NDFRT:N0000000431
database_cross_reference: OMIM:MTHU012488
database_cross_reference: RCD:1AC0.
database_cross_reference: RCD:R0851
database_cross_reference: RCDSY:R0851
database_cross_reference: SNM:F-66105
database_cross_reference: SNMI:F-72405
database_cross_reference: SNOMEDCT_US:139460001
database_cross_reference: SNOMEDCT_US:158479000
database_cross_reference: SNOMEDCT_US:207182009
database_cross_reference: SNOMEDCT_US:2472002

germ cell cancer
type: Class
subclass of: cell type cancer
definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells.
PMOID: PMO:00025359
Subclass_of: cell type cancer
Synonym: 906-909 GERM CELL NEOPLASMS
Synonym: GERM CELL NEOPL
Synonym: GERM CELL NEOPLASMS
Synonym: GERM CELL TUMOR
Synonym: Germ Cell Neoplasm
Synonym: Germ Cell Neoplasms
Synonym: Germ Cell Tumor
Synonym: Germ Cell Tumors
Synonym: Germ cell neoplasm
Synonym: Germ cell neoplasm (morphologic abnormality)
Tree Number: T10.2.1.1.6
database_cross_reference: CCPSS:0016533
database_cross_reference: CHV:0000020732
database_cross_reference: CSP:2016-0850
database_cross_reference: DO:DOID:2994
database_cross_reference: MDR:10075292
database_cross_reference: MEDCIN:355518
database_cross_reference: MSH:D009373
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3708
database_cross_reference: NCI_NCI-GLOSS:CDR0000045695
database_cross_reference: NCI_NICHD:C3708
database_cross_reference: RCD:BBQ..
database_cross_reference: RCD:BBQz.
database_cross_reference: RCD:Xa9AE
database_cross_reference: RCDAE:Xa9AE
database_cross_reference: RCDSY:BBQ..
database_cross_reference: RCDSY:BBQz.
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:M-90600
database_cross_reference: SNMI:M-90643
database_cross_reference: SNOMEDCT_US:115233005
database_cross_reference: SNOMEDCT_US:189839002
database_cross_reference: SNOMEDCT_US:189854008
database_cross_reference: SNOMEDCT_US:28307001
database_cross_reference: SNOMEDCT_US:302853003
database_cross_reference: SNOMEDCT_US:402878003

substance abuse
type: Class
subclass of: substance-related disorder
definition: A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.
PMOID: PMO:00027912
Subclass_of: substance-related disorder
Synonym: ABUSE
Synonym: Abuse, Drug
Synonym: Abuse;drug(s)
Synonym: DRUG ABUSE
Synonym: Drug Abuse
Synonym: Drug abuse
Synonym: Drug abuse (disorder)
Synonym: Drug abuse NOS
Synonym: Drug abuse, NOS
Synonym: Drugs of abuse
Tree Number: T10.3.3.2
database_cross_reference: AOD:0000010555
database_cross_reference: AOD:0000022809
database_cross_reference: AOD:0000022816
database_cross_reference: BI:BI00023
database_cross_reference: CCPSS:0058261
database_cross_reference: CHV:0000004129
database_cross_reference: CHV:0000043256
database_cross_reference: COSTAR:250
database_cross_reference: CSP:0962-7352
database_cross_reference: CST:DRUG DEPEND
database_cross_reference: CST:NERABUSE
database_cross_reference: DO:DOID:302
database_cross_reference: DXP:U000992
database_cross_reference: ICPC2EENG:P19
database_cross_reference: ICPC2P:P19024
database_cross_reference: LCH:U006192
database_cross_reference: LCH_NW:sh85039675
database_cross_reference: LCH_NW:sh94005490
database_cross_reference: LNC:LP36310-8
database_cross_reference: LNC:MTHU019367
database_cross_reference: MDR:10013654
database_cross_reference: MDR:10013655
database_cross_reference: MDR:10074854
database_cross_reference: MEDCIN:314332
database_cross_reference: MEDCIN:339732
database_cross_reference: MEDLINEPLUS:30
database_cross_reference: MSH:D019966
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16522
database_cross_reference: NCI_NCI-GLOSS:CDR0000454752
database_cross_reference: PDQ:CDR0000043326
database_cross_reference: PSY:15220
database_cross_reference: SNM:F-Y0250
database_cross_reference: SNMI:DF-10200
database_cross_reference: SNOMEDCT_US:26416006

substance-related disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning.
PMOID: PMO:00027909
Subclass_of: disease of mental health
Synonym: AODR disorder
Synonym: Alcohol or Other Drug Related disorder
Synonym: SUBSTANCE RELATED DIS
Synonym: Substance-Related Disorder
Synonym: Substance-Related Disorders
Synonym: Substance-Related Disorders [Disease/Finding]
Synonym: Substance-related disorders
Tree Number: T10.3.3
database_cross_reference: AOD:0000004322
database_cross_reference: DO:DOID:303
database_cross_reference: MDR:10064465
database_cross_reference: MSH:D019966
database_cross_reference: NCI:C92203
database_cross_reference: NDFRT:N0000003977

Wissler's syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by four typical symptoms: polymorphous exanthemas, recurrent high fever, leucocytosis and arthralgia.
PMOID: PMO:00025197
Subclass_of: syndrome
Synonym: Subsepsis Allergica
Synonym: Subsepsis Hyperergica
Synonym: Subsepsis hyperergia
Synonym: Subsepsis hyperergia syndrome
Synonym: Syndrome, Wissler's
Synonym: Syndrome, Wissler-Fanconi
Synonym: Wissler Fanconi Syndrome
Synonym: Wissler Syndrome
Synonym: Wissler syndrome
Synonym: Wissler's Syndrome
Tree Number: T10.1.75
database_cross_reference: DO:DOID:3047
database_cross_reference: MDR:10058492
database_cross_reference: MDR:10058493
database_cross_reference: MSH:D014924
database_cross_reference: NDFRT:N0000003165
database_cross_reference: SNM:D-3075
database_cross_reference: SNMI:D1-20612
database_cross_reference: SNOMEDCT_US:68190001

carcinoma
type: Class
subclass of: cell type cancer
definition: A carcinoma that derives_from the cells that line an organ.
PMOID: PMO:00025267
Subclass_of: cell type cancer
Synonym: CARCINOMA
Synonym: CARCINOMA, MALIGNANT
Synonym: Carcinoma
Synonym: Carcinoma (disorder)
Synonym: Carcinoma NOS
Synonym: Carcinoma [Disease/Finding]
Synonym: Carcinoma, NOS
Synonym: Carcinoma, no subtype
Synonym: Carcinoma, no subtype (morphologic abnormality)
Synonym: Carcinomas
Tree Number: T10.2.1.1.2
database_cross_reference: AOD:0000004525
database_cross_reference: CCPSS:1018250
database_cross_reference: CHV:0000002416
database_cross_reference: COSTAR:134
database_cross_reference: CSP:2000-1867
database_cross_reference: CST:CARCINOMA
database_cross_reference: DO:DOID:157
database_cross_reference: DO:DOID:305
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0030731
database_cross_reference: ICD10AM:M8010/3
database_cross_reference: LNC:LA15448-6
database_cross_reference: MDR:10007284
database_cross_reference: MDR:10007423
database_cross_reference: MEDCIN:271392
database_cross_reference: MEDLINEPLUS:25
database_cross_reference: MSH:D002277
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2916
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C2916
database_cross_reference: NCI_CTEP-SDC:10007423
database_cross_reference: NCI_NCI-GLOSS:CDR0000045963
database_cross_reference: NCI_NCI-GLOSS:CDR0000046422
database_cross_reference: NDFRT:N0000000664
database_cross_reference: PSY:07590
database_cross_reference: RCD:BB12.
database_cross_reference: RCD:Xa987
database_cross_reference: RCDAE:Xa987
database_cross_reference: RCDSY:BB12.
database_cross_reference: SNM:M-8010/3
database_cross_reference: SNMI:M-80103
database_cross_reference: SNOMEDCT_US:154433003
database_cross_reference: SNOMEDCT_US:189549006
database_cross_reference: SNOMEDCT_US:269513004
database_cross_reference: SNOMEDCT_US:68453008
database_cross_reference: SNOMEDCT_US:722688002

paratyphoid fever
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.
PMOID: PMO:00029460
Subclass_of: primary bacterial infectious disease
Synonym: Fever, Paratyphoid
Synonym: Fevers, Paratyphoid
Synonym: PARATYPHOID
Synonym: Paratyphoid
Synonym: Paratyphoid A fever
Synonym: Paratyphoid B fever
Synonym: Paratyphoid C fever
Synonym: Paratyphoid Fever
Synonym: Paratyphoid Fever A
Synonym: Paratyphoid Fever B
Tree Number: T10.7.3.1.1
database_cross_reference: CHV:0000009306
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:3055
database_cross_reference: DXP:U001420
database_cross_reference: ICD10:A01.4
database_cross_reference: ICD10AM:A01.4
database_cross_reference: ICD10CM:A01.4
database_cross_reference: ICD9CM:002.9
database_cross_reference: LCH:U003485
database_cross_reference: LCH_NW:sh85097945
database_cross_reference: MDR:10033970
database_cross_reference: MDR:10033971
database_cross_reference: MDR:10033975
database_cross_reference: MDR:10039441
database_cross_reference: MEDCIN:31297
database_cross_reference: MSH:D010284
database_cross_reference: NCI:C34897
database_cross_reference: NDFRT:N0000002324
database_cross_reference: RCD:A01z.
database_cross_reference: RCD:Ayu01
database_cross_reference: RCD:X70GM
database_cross_reference: RCDSY:Ayu01
database_cross_reference: SNM:D-0155
database_cross_reference: SNMI:DE-15150
database_cross_reference: SNOMEDCT_US:154270009
database_cross_reference: SNOMEDCT_US:186092009
database_cross_reference: SNOMEDCT_US:187268002
database_cross_reference: SNOMEDCT_US:266174006
database_cross_reference: SNOMEDCT_US:85904008

malignant glioma
type: Class
subclass of: cell type cancer
definition: A cell type cancer that has material basis in glial cells and is located in brain or located in spine.
PMOID: PMO:00025325
Subclass_of: cell type cancer
Synonym: 938-948 GLIOMAS
Synonym: GLIOMA
Synonym: GLIOMAS
Synonym: Glial Cell Tumor
Synonym: Glial Cell Tumors
Synonym: Glial Neoplasm
Synonym: Glial Tumor
Synonym: Glioma
Synonym: Glioma (disorder)
Synonym: Glioma (morphologic abnormality)
Tree Number: T10.2.1.1.5
database_cross_reference: AOD:0000004650
database_cross_reference: CHV:0000005524
database_cross_reference: COSTAR:U000328
database_cross_reference: CSP:2012-6589
database_cross_reference: DO:DOID:3070
database_cross_reference: DXP:U001709
database_cross_reference: HPO:HP:0009733
database_cross_reference: LCH:U001975
database_cross_reference: LCH_NW:sh85055282
database_cross_reference: MDR:10018338
database_cross_reference: MEDCIN:351509
database_cross_reference: MEDLINEPLUS:173
database_cross_reference: MSH:D005910
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3059
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000045697
database_cross_reference: NCI_NCI-GLOSS:CDR0000045700
database_cross_reference: NCI_NICHD:C3059
database_cross_reference: NDFRT:N0000001348
database_cross_reference: OMIM:MTHU011462
database_cross_reference: RCD:BBb..
database_cross_reference: RCD:BBbz.
database_cross_reference: RCD:X77pI
database_cross_reference: RCDSY:BBb..
database_cross_reference: RCDSY:BBbz.
database_cross_reference: SNM:U000394
database_cross_reference: SNMI:M-93800
database_cross_reference: SNMI:M-93803
database_cross_reference: SNOMEDCT_US:115240006
database_cross_reference: SNOMEDCT_US:189908003
database_cross_reference: SNOMEDCT_US:189909006
database_cross_reference: SNOMEDCT_US:189926000
database_cross_reference: SNOMEDCT_US:393564001
database_cross_reference: SNOMEDCT_US:74532006

nervous system cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer located_in the nervous system that affects the central or peripheral nervous system.
PMOID: PMO:00025865
Subclass_of: organ system cancer
Synonym: NEOPL NERVE TISSUE
Synonym: NEOPL NERVOUS TISSUE
Synonym: NERVE TISSUE NEOPL
Synonym: NERVOUS TISSUE NEOPL
Synonym: Neoplasm, Nerve Tissue
Synonym: Neoplasm, Nervous Tissue
Synonym: Neoplasms, Nerve Tissue
Synonym: Neoplasms, Nerve Tissue [Disease/Finding]
Synonym: Neoplasms, Nervous Tissue
Synonym: Nerve Tissue Neoplasm
Tree Number: T10.2.1.2.3
database_cross_reference: DO:DOID:3093
database_cross_reference: HPO:HP:0030060
database_cross_reference: MSH:D009380
database_cross_reference: NDFRT:N0000002139

thoracic outlet syndrome
type: Class
subclass of: vascular disease
definition: A vascular disease that is characterized by compression at the superior thoracic outlet[1] resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles.
PMOID: PMO:00031860
Subclass_of: vascular disease
Synonym: Aperture Syndrome, Thoracic Outlet
Synonym: CERVICOTHORACIC OUTLET SYNDROME
Synonym: Neurovascular Syndrome, Thoracic Outlet
Synonym: Outlet Syndrome, Thoracic
Synonym: Outlet Syndromes, Thoracic
Synonym: Superior Thoracic Aperture Syndrome
Synonym: Syndrome, Thoracic Outlet
Synonym: Syndromes, Thoracic Outlet
Synonym: THORACIC OUTLET SYNDROME
Synonym: TOS
Tree Number: T10.8.3.3.6
database_cross_reference: CCPSS:0049922
database_cross_reference: CHV:0000012207
database_cross_reference: COSTAR:U000669
database_cross_reference: DO:DOID:3103
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:G54.0
database_cross_reference: ICPC2P:N94006
database_cross_reference: LCH:U004662
database_cross_reference: LCH_NW:sh85134950
database_cross_reference: MDR:10048627
database_cross_reference: MEDCIN:33382
database_cross_reference: MEDLINEPLUS:1251
database_cross_reference: MSH:D013901
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:353.0
database_cross_reference: NCI:C85188
database_cross_reference: NDFRT:N0000002928
database_cross_reference: RCD:F3303
database_cross_reference: SNM:D-3310
database_cross_reference: SNMI:DA-42025
database_cross_reference: SNOMEDCT_US:128210009
database_cross_reference: SNOMEDCT_US:193106006
database_cross_reference: SNOMEDCT_US:193107002
database_cross_reference: SNOMEDCT_US:193108007
database_cross_reference: SNOMEDCT_US:2040007
database_cross_reference: SNOMEDCT_US:212769008
database_cross_reference: SNOMEDCT_US:393578000

toxascariasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of dogs, cats and foxes with Toxascaris leonina causing damage to the lining of the intestine. The symptoms include diarrhea, vomiting and loss of appetite.
PMOID: PMO:00029671
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Toxascariases
Synonym: Toxascariasis
Synonym: Toxascariasis [Disease/Finding]
Tree Number: T10.7.4.1.36
database_cross_reference: DO:DOID:3107
database_cross_reference: MSH:D017227
database_cross_reference: NDFRT:N0000003556

ascaridiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia.
PMOID: PMO:00029674
Subclass_of: parasitic helminthiasis infectious disease
Tree Number: T10.7.4.1.39
database_cross_reference: DO:DOID:3108

hepatobiliary disease
type: Class
subclass of: gastrointestinal system disease
definition: A gastrointestinal system disease that is located_in the liver and/or biliary tract.
PMOID: PMO:00033483
Subclass_of: gastrointestinal system disease
Synonym: DISEASES OF THE LIVER AND BILIARY SYSTEM
Synonym: HEPATOBILIARY DISEASE
Synonym: Hepat
Synonym: Hepatobiliary Disorder
Synonym: Hepatobiliary disease
Synonym: Hepatobiliary disease NOS
Synonym: Hepatobiliary disorders
Synonym: Liver and Biliary Disease
Synonym: Liver and Biliary Disorder
Synonym: Liver and Biliary System Disorder
Tree Number: T10.8.11.4
database_cross_reference: CCPSS:0023181
database_cross_reference: CHV:0000047671
database_cross_reference: DO:DOID:3118
database_cross_reference: MDR:10019805
database_cross_reference: MDR:10051306
database_cross_reference: MDR:10062000
database_cross_reference: MEDCIN:363343
database_cross_reference: NCI:C3959
database_cross_reference: SNMI:D5-80000

gastrointestinal system cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.
PMOID: PMO:00026352
Subclass_of: organ system cancer
Synonym: DIGESTIVE SYSTEM NEOPL
Synonym: Digest.syst.neop.unspec.nature
Synonym: Digestive System Neoplasm
Synonym: Digestive System Neoplasms
Synonym: Digestive System Neoplasms [Disease/Finding]
Synonym: Digestive neoplasm NOS
Synonym: GI tumor
Synonym: NEOPL DIGESTIVE SYSTEM
Synonym: Neoplasm of digestive system
Synonym: Neoplasm of digestive system (disorder)
Tree Number: T10.2.1.2.8
database_cross_reference: AOD:0000023050
database_cross_reference: CSP:4000-0164
database_cross_reference: DO:DOID:3119
database_cross_reference: ICD9CM:239.0
database_cross_reference: ICPC2P:D78010
database_cross_reference: MDR:10029090
database_cross_reference: MEDCIN:355284
database_cross_reference: MSH:D004067
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000974
database_cross_reference: RCD:BA00.
database_cross_reference: SNOMEDCT_US:128348002
database_cross_reference: SNOMEDCT_US:128415001
database_cross_reference: SNOMEDCT_US:189527000

gastric outlet obstruction
type: Class
subclass of: stomach disease
PMOID: PMO:00033477
Subclass_of: stomach disease
Synonym: Gastric Outlet Obstruction
Synonym: PS - Pyloric stenosis
Synonym: PYLORIC STENOSIS
Synonym: PYLORIC STRICTURE
Synonym: Pyloric Stenosis
Synonym: Pyloric Stenosis [Disease/Finding]
Synonym: Pyloric stenosis
Synonym: Pyloric stenosis (disorder)
Synonym: Pyloric stenosis NOS
Synonym: Pylorus--Stenosis
Tree Number: T10.8.11.3.9
database_cross_reference: CCPSS:0042882
database_cross_reference: CHV:0000010436
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1248-7189
database_cross_reference: CSP:1250-9688
database_cross_reference: CST:STENO PYLOR
database_cross_reference: DO:DOID:12639
database_cross_reference: DXP:U003294
database_cross_reference: HPO:HP:0002021
database_cross_reference: ICD10CM:K31.1
database_cross_reference: LCH:U003960
database_cross_reference: LCH_NW:sh85109286
database_cross_reference: MDR:10037621
database_cross_reference: MDR:10037624
database_cross_reference: MDR:10041994
database_cross_reference: MEDCIN:30166
database_cross_reference: MSH:D011707
database_cross_reference: MTH:U002205
database_cross_reference: NCI:C34966
database_cross_reference: NCI_NICHD:C34966
database_cross_reference: NDFRT:N0000002561
database_cross_reference: OMIM:MTHU002185
database_cross_reference: RCD:Xa9C2
database_cross_reference: SNOMEDCT_US:367403001

acute porphyria
type: Class
subclass of: porphyria
definition: A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis.
PMOID: PMO:00029034
Subclass_of: porphyria
Synonym: Hepatic Porphyria
Synonym: Hepatic Porphyrias
Synonym: Hepatic porphyria
Synonym: Hepatic porphyria (disorder)
Synonym: Hepatic porphyria, NOS
Synonym: Porphyria hepatic
Synonym: Porphyria, Hepatic
Synonym: Porphyria, hepatic
Synonym: Porphyrias, Hepatic
Synonym: Porphyrias, Hepatic [Disease/Finding]
Tree Number: T10.6.2.6.1
database_cross_reference: AOD:0000005785
database_cross_reference: DO:DOID:3133
database_cross_reference: MDR:10036184
database_cross_reference: MSH:D017094
database_cross_reference: NDFRT:N0000003528
database_cross_reference: SNM:D-4220
database_cross_reference: SNMI:D6-88300
database_cross_reference: SNOMEDCT_US:55056006

facial dermatosis
type: Class
subclass of: skin disease
PMOID: PMO:00033887
Subclass_of: skin disease
Synonym: Dermatoses, Facial
Synonym: Dermatosis, Facial
Synonym: Facial Dermatoses
Synonym: Facial Dermatoses [Disease/Finding]
Synonym: Facial Dermatosis
Tree Number: T10.8.12.2.20
database_cross_reference: DO:DOID:3134
database_cross_reference: MSH:D005148
database_cross_reference: NDFRT:N0000001190

scalp dermatosis
type: Class
subclass of: skin disease
PMOID: PMO:00033878
Subclass_of: skin disease
Synonym: Dermatoses, Scalp
Synonym: Dermatosis of scalp
Synonym: Dermatosis of scalp (disorder)
Synonym: Dermatosis, Scalp
Synonym: Scalp Dermatoses
Synonym: Scalp Dermatoses [Disease/Finding]
Synonym: Scalp Dermatosis
Tree Number: T10.8.12.2.15
database_cross_reference: DO:DOID:3136
database_cross_reference: MSH:D012536
database_cross_reference: NDFRT:N0000002682
database_cross_reference: SNOMEDCT_US:402694007

scleredema adultorum
type: Class
subclass of: skin disease
PMOID: PMO:00032278
Subclass_of: skin disease
Synonym: Buschke Scleredema
Synonym: Buschke Scleredema Adultorum
Synonym: Buschke Scleredema Diabeticorum
Synonym: Buschke's Scleredema
Synonym: Buschke's scleredema
Synonym: Buschkes Scleredema
Synonym: Diabeticorum, Scleredema
Synonym: Diabeticorums, Scleredema
Synonym: Scleredema
Synonym: Scleredema (disorder)
Tree Number: T10.8.12.2.36
database_cross_reference: CHV:0000011113
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2716-6810
database_cross_reference: DO:DOID:3140
database_cross_reference: MDR:10051238
database_cross_reference: MDR:10055953
database_cross_reference: MSH:D012592
database_cross_reference: NCI:C85057
database_cross_reference: NDFRT:N0000002698
database_cross_reference: SNM:D-3888
database_cross_reference: SNMI:D0-00044
database_cross_reference: SNOMEDCT_US:72967001
database_cross_reference: SNOMEDCT_US:95323007

mucinoses
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032277
Subclass_of: connective tissue disease
Synonym: Mucinoses
Synonym: Mucinoses [Disease/Finding]
Synonym: Mucinosis
Synonym: Mucinosis (morphologic abnormality)
Synonym: Mucinosis, NOS
Synonym: mucinosis
Tree Number: T10.8.4.1.10
database_cross_reference: CHV:0000018009
database_cross_reference: DO:DOID:3141
database_cross_reference: MSH:D017520
database_cross_reference: NDFRT:N0000003596
database_cross_reference: SNM:D-3874
database_cross_reference: SNMI:M-55670
database_cross_reference: SNOMEDCT_US:11528001

leg dermatosis
type: Class
subclass of: skin disease
PMOID: PMO:00033906
Subclass_of: skin disease
Synonym: Dermatoses, Leg
Synonym: Dermatosis, Leg
Synonym: Leg Dermatoses
Synonym: Leg Dermatoses [Disease/Finding]
Synonym: Leg Dermatosis
Tree Number: T10.8.12.2.29
database_cross_reference: DO:DOID:3142
database_cross_reference: MSH:D007868
database_cross_reference: MTH:701
database_cross_reference: NDFRT:N0000001794

cutis laxa
type: Class
subclass of: skin disease
definition: A skin disease characterized by loose, hanging, wrinkled skin lacking in elasticity.
PMOID: PMO:00033928
Subclass_of: skin disease
Synonym: Baggy eyes
Synonym: Chalazoderma
Synonym: Chalazodermia
Synonym: Cutis Laxa
Synonym: Cutis Laxa [Disease/Finding]
Synonym: Cutis laxa
Synonym: Cutis laxa (disorder)
Synonym: Cutis laxa (hyperelastica)
Synonym: Cutis laxa, NOS
Synonym: Dermatochalasia
Tree Number: T10.8.12.2.32
database_cross_reference: CHV:0000003512
database_cross_reference: CHV:0000057932
database_cross_reference: CSP:2716-6258
database_cross_reference: DO:DOID:3144
database_cross_reference: HPO:HP:0000973
database_cross_reference: HPO:HP:0010750
database_cross_reference: ICD10CM:Q82.8
database_cross_reference: MDR:10011692
database_cross_reference: MDR:10012500
database_cross_reference: MDR:10057064
database_cross_reference: MEDCIN:31802
database_cross_reference: MSH:D003483
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84663
database_cross_reference: NDFRT:N0000000884
database_cross_reference: OMIM:MTHU006920
database_cross_reference: OMIM:MTHU007951
database_cross_reference: OMIM:MTHU011913
database_cross_reference: OMIM:MTHU035760
database_cross_reference: RCD:X50CO
database_cross_reference: RCDAE:X50CO
database_cross_reference: SNM:M-56810
database_cross_reference: SNM:M-56840
database_cross_reference: SNMI:D6-90300
database_cross_reference: SNOMEDCT_US:238825007
database_cross_reference: SNOMEDCT_US:58588007

lipid metabolism disorder
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that involves the creation and degradation of lipids.
PMOID: PMO:00029247
Subclass_of: inherited metabolic disorder
Synonym: Inborn error of lipid metabolism
Synonym: Inborn errors of lipid metabolism
Synonym: LIPID METAB INBORN ERR
Synonym: LIPID METAB INBORN ERRORS
Synonym: Lipid Metabolism, Inborn Error
Synonym: Lipid Metabolism, Inborn Errors
Synonym: Lipid Metabolism, Inborn Errors [Disease/Finding]
Synonym: dyslipidemia
Synonym: fatty acid metabolism disorder
Tree Number: T10.6.2.18
database_cross_reference: DO:DOID:3146
database_cross_reference: MDR:10059674
database_cross_reference: MDR:10072272
database_cross_reference: MSH:D008052
database_cross_reference: NDFRT:N0000001848

lipomatosis
type: Class
subclass of: skin disease
PMOID: PMO:00033896
Subclass_of: skin disease
Synonym: 741 LIPOMATOSES
Synonym: LIPOMATOSES
Synonym: Lipomatoses
Synonym: Lipomatosis
Synonym: Lipomatosis (disorder)
Synonym: Lipomatosis (morphologic abnormality)
Synonym: Lipomatosis NOS
Synonym: Lipomatosis [Disease/Finding]
Synonym: Lipomatosis, NOS
Synonym: lipomatoses
Tree Number: T10.8.12.2.27
database_cross_reference: CHV:0000007465
database_cross_reference: DO:DOID:3153
database_cross_reference: ICD10CM:E88.2
database_cross_reference: MDR:10051847
database_cross_reference: MDR:10061228
database_cross_reference: MEDCIN:338593
database_cross_reference: MSH:D008068
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001855
database_cross_reference: RCD:X50EG
database_cross_reference: SNM:M-74100
database_cross_reference: SNM:U000375
database_cross_reference: SNMI:M-74100
database_cross_reference: SNOMEDCT_US:37095002
database_cross_reference: SNOMEDCT_US:402693001

hypomelanosis of Ito
type: Class
subclass of: skin disease
definition: A skin disease.
PMOID: PMO:00033955
Subclass_of: skin disease
Synonym: Bloch-Siemans syndrome
Synonym: HMI
Synonym: HMI - Hypomelanosis of Ito
Synonym: HYPOMELANOSIS OF ITO
Synonym: Hypomelanosis of Ito
Synonym: Hypomelanosis of Ito (disorder)
Synonym: Hypomelanosis of Ito [Ambiguous]
Synonym: INCONTINENTIA PIGMENTI ACHROMIANS
Synonym: INCONTINENTIA PIGMENTI, TYPE I, FORMERLY
Synonym: IP1, FORMERLY
Tree Number: T10.8.12.2.34
database_cross_reference: CHV:0000006980
database_cross_reference: DO:DOID:3156
database_cross_reference: DRUGBANK:DB11933
database_cross_reference: JABL:368
database_cross_reference: MDR:10075301
database_cross_reference: MDR:10075302
database_cross_reference: MSH:D010859
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C7582
database_cross_reference: OMIM:300337
database_cross_reference: RCD:X78VE
database_cross_reference: RCDAE:X78VE
database_cross_reference: SNM:D-5413
database_cross_reference: SNM:M-57230
database_cross_reference: SNMI:D4-01013
database_cross_reference: SNMI:D4-40374
database_cross_reference: SNOMEDCT_US:218358001
database_cross_reference: SNOMEDCT_US:254202001
database_cross_reference: SNOMEDCT_US:254816001
database_cross_reference: SNOMEDCT_US:367520004
database_cross_reference: SNOMEDCT_US:48543002
database_cross_reference: SNOMEDCT_US:806001

hand dermatosis
type: Class
subclass of: skin disease
PMOID: PMO:00033962
Subclass_of: skin disease
Synonym: Dermatoses, Hand
Synonym: Dermatosis, Hand
Synonym: Hand Dermatoses
Synonym: Hand Dermatoses [Disease/Finding]
Synonym: Hand Dermatosis
Tree Number: T10.8.12.2.42
database_cross_reference: DO:DOID:3158
database_cross_reference: MSH:D006229
database_cross_reference: NDFRT:N0000001410

squamous cell neoplasm
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities.
PMOID: PMO:00027374
Subclass_of: cell type benign neoplasm
Synonym: 805-808 SQUAMOUS CELL NEOPLASMS
Synonym: Cell Neoplasm, Squamous
Synonym: Cell Neoplasms, Squamous
Synonym: Epidermoid Cell Neoplasm
Synonym: Epidermoid Cell Tumor
Synonym: Epidermoid cell tumor
Synonym: NEOPL SQUAMOUS CELL
Synonym: Neoplasm, Squamous Cell
Synonym: Neoplasms, Squamous Cell
Synonym: Neoplasms, Squamous Cell [Disease/Finding]
Tree Number: T10.2.3.1.6
database_cross_reference: CHV:0000058006
database_cross_reference: DO:DOID:3168
database_cross_reference: MSH:D018307
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3792
database_cross_reference: NDFRT:N0000003771
database_cross_reference: RCD:X77my
database_cross_reference: RCDAE:X77my
database_cross_reference: SNMI:M-80500
database_cross_reference: SNOMEDCT_US:118286007
database_cross_reference: SNOMEDCT_US:134208005
database_cross_reference: SNOMEDCT_US:189560002

spinal cord disease
type: Class
subclass of: central nervous system disease
PMOID: PMO:00030710
Subclass_of: central nervous system disease
Synonym: A-24 MYELOPATHIES
Synonym: Disease of spinal cord
Synonym: Disease of spinal cord, NOS
Synonym: Disease of spinal cord, unspecified
Synonym: MP - Myelopathy
Synonym: MYELOPATHIES
Synonym: MYELOPATHY
Synonym: Myelopathies
Synonym: Myelopathy
Synonym: Myelopathy (disorder)
Tree Number: T10.8.2.9.14
database_cross_reference: AOD:0000006228
database_cross_reference: CCPSS:0045930
database_cross_reference: CHV:0000011614
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0427-3773
database_cross_reference: CSP:2042-5832
database_cross_reference: CST:MYELITIS
database_cross_reference: CST:NER/CNS/SC
database_cross_reference: DO:DOID:319
database_cross_reference: DXP:U003775
database_cross_reference: HPO:HP:0002143
database_cross_reference: HPO:HP:0002196
database_cross_reference: ICD10:G95.9
database_cross_reference: ICD10AM:G95.9
database_cross_reference: ICD10CM:G95.9
database_cross_reference: ICD9CM:336.9
database_cross_reference: LCH_NW:sh85126670
database_cross_reference: MDR:10028570
database_cross_reference: MDR:10028574
database_cross_reference: MDR:10041550
database_cross_reference: MDR:10045757
database_cross_reference: MDR:10061367
database_cross_reference: MEDCIN:273824
database_cross_reference: MEDCIN:90078
database_cross_reference: MEDLINEPLUS:410
database_cross_reference: MSH:D013118
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:336.9
database_cross_reference: NCI:C97110
database_cross_reference: NDFRT:N0000002793
database_cross_reference: OMIM:MTHU005441
database_cross_reference: RCD:F163z
database_cross_reference: RCD:XC0e9
database_cross_reference: RCD:XE15Q
database_cross_reference: SNM:D-8X00
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DA-24000
database_cross_reference: SNMI:DA-24001
database_cross_reference: SNOMEDCT_US:155020007
database_cross_reference: SNOMEDCT_US:192908002
database_cross_reference: SNOMEDCT_US:192913003
database_cross_reference: SNOMEDCT_US:267587000
database_cross_reference: SNOMEDCT_US:267695005
database_cross_reference: SNOMEDCT_US:48522003
database_cross_reference: SNOMEDCT_US:95648003

tropical spastic paraparesis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in inflammation located in spinal cord, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.
PMOID: PMO:00029371
Subclass_of: viral infectious disease
Synonym: FAMILIAL SPASTIC PARAPARESIS, HTLV-1-ASSOCIATED
Synonym: Familial Spastic Paraparesis, Htlv 1 Associated
Synonym: Familial Spastic Paraparesis, Htlv-1-Associated
Synonym: HAM
Synonym: HAM - HTLV 1-associated myelopathy
Synonym: HAM-HTLV 1-associat myelopathy
Synonym: HTLV 1-associated myelopathy
Synonym: HTLV I ASSOC MYELOPATHIES
Synonym: HTLV I ASSOC MYELOPATHY
Synonym: HTLV I ASSOC MYELOPATHY TROPICAL SPASTIC PARAPARESIS
Tree Number: T10.7.2.21
database_cross_reference: CHV:0000009282
database_cross_reference: CSP:2057-3666
database_cross_reference: CSP:3130-7431
database_cross_reference: DO:DOID:321
database_cross_reference: ICD10:G04.1
database_cross_reference: ICD10AM:G04.1
database_cross_reference: ICD10CM:G04.1
database_cross_reference: MDR:10019104
database_cross_reference: MDR:10020427
database_cross_reference: MDR:10020456
database_cross_reference: MDR:10044696
database_cross_reference: MDR:10060479
database_cross_reference: MDR:10067606
database_cross_reference: MEDCIN:337417
database_cross_reference: MSH:D015493
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003276
database_cross_reference: OMIM:159580
database_cross_reference: RCD:X001f
database_cross_reference: SNM:D-8765
database_cross_reference: SNMI:DA-44333
database_cross_reference: SNOMEDCT_US:192733005
database_cross_reference: SNOMEDCT_US:45129002
database_cross_reference: SNOMEDCT_US:714279000

lysosomal storage disease
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function.
PMOID: PMO:00029047
Subclass_of: inherited metabolic disorder
Synonym: DISORDERS OF LYSOSOMAL ENZYMES
Synonym: Disease, Lysosomal Storage
Synonym: Diseases, Lysosomal Storage
Synonym: Disorder of Lysosomal Enzymes
Synonym: Disorder of lysosomal enzyme
Synonym: Disorder of lysosomal enzyme (disorder)
Synonym: Disorder of lysosomal enzyme, NOS
Synonym: Disorder, Lysosomal Enzyme
Synonym: Disorders, Lysosomal Enzyme
Synonym: Enzyme Disorder, Lysosomal
Tree Number: T10.6.2.8
database_cross_reference: CHV:0000015411
database_cross_reference: CSP:1849-5878
database_cross_reference: DO:DOID:3211
database_cross_reference: LCH_NW:sh85079196
database_cross_reference: LNC:LP111174-1
database_cross_reference: LNC:MTHU036683
database_cross_reference: MDR:10024579
database_cross_reference: MSH:D016464
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C61250
database_cross_reference: NCI_CDISC:C61250
database_cross_reference: NCI_NICHD:C61250
database_cross_reference: NDFRT:N0000003414
database_cross_reference: SNMI:D6-70000
database_cross_reference: SNOMEDCT_US:23585005
database_cross_reference: SNOMEDCT_VET:280081000009104

tracheal disease
type: Class
subclass of: upper respiratory tract disease
PMOID: PMO:00032482
Subclass_of: upper respiratory tract disease
Synonym: DISEASES OF THE TRACHEA
Synonym: Disease of trachea
Synonym: Disease of trachea (disorder)
Synonym: Disease of trachea, NOS
Synonym: Disease, Tracheal
Synonym: Diseases, Tracheal
Synonym: Disorder of Trachea
Synonym: Disorder of trachea
Synonym: Disorder of trachea (disorder)
Synonym: SECTION 2-1 DISEASES OF THE TRACHEA
Tree Number: T10.8.5.2.3
database_cross_reference: CHV:0000012424
database_cross_reference: CST:RES/TRAC
database_cross_reference: DO:DOID:3225
database_cross_reference: HPO:HP:0002778
database_cross_reference: ICD10CM:S12.8
database_cross_reference: LCH_NW:sh85136402
database_cross_reference: MDR:10053490
database_cross_reference: MEDCIN:356625
database_cross_reference: MEDLINEPLUS:5448
database_cross_reference: MSH:D014133
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35079
database_cross_reference: NCI_NICHD:C35079
database_cross_reference: NDFRT:N0000002993
database_cross_reference: RCD:X104I
database_cross_reference: SNMI:D2-10000
database_cross_reference: SNOMEDCT_US:47125007

gastric dilatation
type: Class
subclass of: stomach disease
PMOID: PMO:00033476
Subclass_of: stomach disease
Synonym: DILATATION STOMACH
Synonym: DILATION OF STOMACH
Synonym: Dilatation of stomach
Synonym: Dilatation stomach
Synonym: Dilatation, Gastric
Synonym: Dilatation, Stomach
Synonym: Dilated stomach
Synonym: Dilation of stomach
Synonym: Dilation, Gastric
Synonym: Dilation, Stomach
Tree Number: T10.8.11.3.8
database_cross_reference: CCPSS:1003703
database_cross_reference: CHV:0000011739
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1248-7212
database_cross_reference: CST:STOMACH DILAT
database_cross_reference: DO:DOID:3229
database_cross_reference: MDR:10013005
database_cross_reference: MDR:10013008
database_cross_reference: MDR:10013015
database_cross_reference: MDR:10013017
database_cross_reference: MDR:10017779
database_cross_reference: MDR:10042100
database_cross_reference: MDR:10069737
database_cross_reference: MSH:D013271
database_cross_reference: NDFRT:N0000002825
database_cross_reference: OMIM:MTHU045179

high pressure neurological syndrome
type: Class
subclass of: central nervous system disease
PMOID: PMO:00030709
Subclass_of: central nervous system disease
Synonym: HPNS
Synonym: HPNSs
Synonym: High Pressure Nervous Syndrome
Synonym: High Pressure Neural Syndrome
Synonym: High Pressure Neurological Syndrome
Synonym: High Pressure Neurological Syndrome [Disease/Finding]
Synonym: High pressure neurologic syndrome
Synonym: high pressure nervous syndrome
Synonym: high pressure nervous syndrome (HPNS)
Tree Number: T10.8.2.9.13
database_cross_reference: CHV:0000006136
database_cross_reference: DO:DOID:3230
database_cross_reference: MSH:D006610
database_cross_reference: NDFRT:N0000001536
database_cross_reference: SNM:D-8916

ischemia
type: Class
subclass of: vascular disease
definition: A vascular disease that is characterized by a restriction in blood supply to tissues.
PMOID: PMO:00031974
Subclass_of: vascular disease
Synonym: ISCHEMIA
Synonym: Ischaemia
Synonym: Ischaemia NOS
Synonym: Ischaemia, NOS
Synonym: Ischemia
Synonym: Ischemia (disorder)
Synonym: Ischemia NOS
Synonym: Ischemia [Disease/Finding]
Synonym: Ischemia, NOS
Synonym: Ischemias
Tree Number: T10.8.3.3.9
database_cross_reference: AOD:0000005321
database_cross_reference: CCPSS:0042499
database_cross_reference: CHV:0000006936
database_cross_reference: COSTAR:U000392
database_cross_reference: CSP:0571-6706
database_cross_reference: DO:DOID:326
database_cross_reference: LCH:U002515
database_cross_reference: LCH_NW:sh85068338
database_cross_reference: MDR:10050000
database_cross_reference: MDR:10054438
database_cross_reference: MDR:10061255
database_cross_reference: MEDCIN:351304
database_cross_reference: MSH:D007511
database_cross_reference: MTH:U003303
database_cross_reference: NCI:C34738
database_cross_reference: NCI_FDA:1942
database_cross_reference: NCI_NCI-GLOSS:CDR0000630922
database_cross_reference: NDFRT:N0000001711
database_cross_reference: PSY:26660
database_cross_reference: RCD:X79pz
database_cross_reference: SNM:F-72240
database_cross_reference: SNMI:F-39340
database_cross_reference: SNOMEDCT_US:52674009

phagocyte bactericidal dysfunction
type: Class
subclass of: primary immunodeficiency disease
definition: A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection.
PMOID: PMO:00032681
Subclass_of: primary immunodeficiency disease
Synonym: Bactericidal Dysfunction, Phagocyte
Synonym: Bactericidal Dysfunctions, Phagocyte
Synonym: Dysfunction, Phagocyte Bactericidal
Synonym: Dysfunctions, Phagocyte Bactericidal
Synonym: Phagocyte Bactericidal Dysfunction
Synonym: Phagocyte Bactericidal Dysfunction [Disease/Finding]
Synonym: Phagocyte Bactericidal Dysfunctions
Synonym: phagocytic dysfunction
Tree Number: T10.8.6.1.6
database_cross_reference: CSP:0427-7579
database_cross_reference: DO:DOID:3262
database_cross_reference: MSH:D010585
database_cross_reference: NDFRT:N0000002383

monkeypox
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection of primates, rodents and humans, located in skin, has material basis in Monkeypox virus, which is transmitted by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted by fomites, and transmitted by respiratory droplets. The infection has symptom fever, has symptom muscle ache, has symptom headache, and has symptom lymphadenopathy.
PMOID: PMO:00029377
Subclass_of: viral infectious disease
Synonym: Human monkeypox
Synonym: Human monkeypox (disorder)
Tree Number: T10.7.2.27
database_cross_reference: DO:DOID:3292
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:D-0407
database_cross_reference: SNMI:DE-31410
database_cross_reference: SNOMEDCT_US:25157001
database_cross_reference: SNOMEDCT_US:359811007

vaccinia
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.
PMOID: PMO:00029450
Subclass_of: viral infectious disease
Synonym: VACCINIA
Synonym: Vaccinia
Synonym: Vaccinia (disorder)
Synonym: Vaccinia [Disease/Finding]
Synonym: Vaccinia, NOS
Synonym: Vaccinias
Synonym: vaccinia (diagnosis)
Tree Number: T10.7.2.80
database_cross_reference: CHV:0000012856
database_cross_reference: DO:DOID:3298
database_cross_reference: DXP:NOCODE
database_cross_reference: LCH:U004885
database_cross_reference: LCH_NW:sh85141721
database_cross_reference: MDR:10066048
database_cross_reference: MEDCIN:277706
database_cross_reference: MSH:D014615
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003103
database_cross_reference: RCD:X5004
database_cross_reference: SNM:D-0492
database_cross_reference: SNMI:DE-31420
database_cross_reference: SNOMEDCT_US:111852003

gonadoblastoma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that is composed_of a mixture of gonadal elements.
PMOID: PMO:00027435
Subclass_of: cell type benign neoplasm
Synonym: GBY
Synonym: GBY - Gonadoblastoma
Synonym: GONADOBLASTOMA
Synonym: Gonadoblastoma
Synonym: Gonadoblastoma (morphologic abnormality)
Synonym: Gonadoblastoma [Disease/Finding]
Synonym: Gonadoblastomas
Synonym: Gonocytoma
Synonym: gonadoblastomas
Tree Number: T10.2.3.1.18
database_cross_reference: CHV:0000021004
database_cross_reference: CSP:2016-0850
database_cross_reference: DO:DOID:3301
database_cross_reference: HPO:HP:0000150
database_cross_reference: ICD10AM:M9073/1
database_cross_reference: MDR:10018506
database_cross_reference: MSH:D018238
database_cross_reference: NCI:C3754
database_cross_reference: NDFRT:N0000003712
database_cross_reference: OMIM:424500
database_cross_reference: OMIM:MTHU014910
database_cross_reference: RCD:BBQ6.
database_cross_reference: SNM:M-9073/1
database_cross_reference: SNMI:M-90731
database_cross_reference: SNOMEDCT_US:74751003

central nervous system disease
type: Class
subclass of: nervous system disease
definition: A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.
PMOID: PMO:00030170
Subclass_of: nervous system disease
Synonym: CENTRAL NERVOUS SYSTEM DISORDER
Synonym: CNS DIS
Synonym: CNS DISORDER (NOS)
Synonym: CNS Disease
Synonym: CNS Diseases
Synonym: CNS diseases
Synonym: CNS disorder
Synonym: CNS disorder (NOS)
Synonym: CNS disorder (disorder)
Synonym: CNS disorders NOS
Tree Number: T10.8.2.9
database_cross_reference: AOD:0000006114
database_cross_reference: AOD:0000023594
database_cross_reference: CHV:0000002621
database_cross_reference: CSP:2042-4612
database_cross_reference: CST:CNS DEPRESS
database_cross_reference: DO:DOID:331
database_cross_reference: HPO:HP:0002011
database_cross_reference: ICD10:G96.9
database_cross_reference: ICD10AM:G96.9
database_cross_reference: ICD10CM:G96.9
database_cross_reference: LCH_NW:sh85021909
database_cross_reference: MDR:10007943
database_cross_reference: MDR:10007944
database_cross_reference: MDR:10009712
database_cross_reference: MDR:10013202
database_cross_reference: MDR:10029204
database_cross_reference: MEDCIN:337657
database_cross_reference: MSH:D002493
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:349.9
database_cross_reference: NCI:C2934
database_cross_reference: NCI_NICHD:C2934
database_cross_reference: NDFRT:N0000000709
database_cross_reference: PSY:08110
database_cross_reference: RCD:FyuAH
database_cross_reference: RCD:XE189
database_cross_reference: RCD:XM1RF
database_cross_reference: RCDSY:FyuAH
database_cross_reference: SNM:D-8002
database_cross_reference: SNMI:DA-00000
database_cross_reference: SNOMEDCT_US:138748005
database_cross_reference: SNOMEDCT_US:154981003
database_cross_reference: SNOMEDCT_US:155049004
database_cross_reference: SNOMEDCT_US:155059003
database_cross_reference: SNOMEDCT_US:192641002
database_cross_reference: SNOMEDCT_US:193076009
database_cross_reference: SNOMEDCT_US:194566008
database_cross_reference: SNOMEDCT_US:23853001
database_cross_reference: SNOMEDCT_US:267144009
database_cross_reference: SNOMEDCT_US:267679005
database_cross_reference: SNOMEDCT_US:267700003
database_cross_reference: SNOMEDCT_US:267702006
database_cross_reference: SNOMEDCT_US:275539005

bipolar disorder
type: Class
subclass of: mood disorder
definition: A mood disorder that involves alternating periods of mania and depression.
PMOID: PMO:00028198
Subclass_of: mood disorder
Synonym: 9-51 BIPOLAR DISORDERS
Synonym: Affective Psychosis, Bipolar
Synonym: BIPOLAR AFFECTIVE DISORDER
Synonym: BIPOLAR DIS
Synonym: BIPOLAR DISORDER
Synonym: BIPOLAR DISORDERS
Synonym: BPAD
Synonym: Bi-polar Disorder
Synonym: Bipolar Affective Disorder
Synonym: Bipolar Affective Psychosis
Tree Number: T10.3.12.2.2
database_cross_reference: AOD:0000006517
database_cross_reference: AOD:0000023847
database_cross_reference: AOD:0000023848
database_cross_reference: BI:BI00671
database_cross_reference: CCPSS:1017813
database_cross_reference: CHV:0000001917
database_cross_reference: COSTAR:106
database_cross_reference: COSTAR:468
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2483-6684
database_cross_reference: CST:MANIC DEPRESS REACT
database_cross_reference: DO:DOID:3312
database_cross_reference: HPO:HP:0007302
database_cross_reference: ICD10:F31
database_cross_reference: ICD10:F31.9
database_cross_reference: ICD10AM:F31
database_cross_reference: ICD10AM:F31.9
database_cross_reference: ICD10CM:F31
database_cross_reference: ICD10CM:F31.9
database_cross_reference: ICD9CM:296.80
database_cross_reference: ICPC2P:P73002
database_cross_reference: ICPC2P:P73004
database_cross_reference: ICPC2P:P73007
database_cross_reference: ICPC2P:P73012
database_cross_reference: LCH_NW:sh85080541
database_cross_reference: LNC:MTHU026189
database_cross_reference: MDR:10004908
database_cross_reference: MDR:10004935
database_cross_reference: MDR:10004938
database_cross_reference: MDR:10026754
database_cross_reference: MDR:10026755
database_cross_reference: MDR:10026756
database_cross_reference: MDR:10026757
database_cross_reference: MDR:10026758
database_cross_reference: MDR:10037240
database_cross_reference: MDR:10037954
database_cross_reference: MDR:10057667
database_cross_reference: MEDCIN:32775
database_cross_reference: MEDLINEPLUS:600
database_cross_reference: MSH:D001714
database_cross_reference: MTH:106
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:296.80
database_cross_reference: NCI:C34423
database_cross_reference: NCI_NICHD:C34423
database_cross_reference: NDFRT:N0000000553
database_cross_reference: OMIM:611535
database_cross_reference: OMIM:MTHU036661
database_cross_reference: PSY:06033
database_cross_reference: PSY:06034
database_cross_reference: PSY:06035
database_cross_reference: PSY:29457
database_cross_reference: PSY:29460
database_cross_reference: RCD:E117.
database_cross_reference: RCD:E1170
database_cross_reference: RCD:E117z
database_cross_reference: RCD:Eu31z
database_cross_reference: RCD:X00SM
database_cross_reference: RCDSY:Eu31z
database_cross_reference: SNM:D-9101
database_cross_reference: SNMI:D9-51000
database_cross_reference: SNOMEDCT_US:13746004
database_cross_reference: SNOMEDCT_US:154871001
database_cross_reference: SNOMEDCT_US:191646009

angiomyolipoma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that from perivascular epithelioid cells.
PMOID: PMO:00027414
Subclass_of: cell type benign neoplasm
Synonym: Angiomyolipoma
Synonym: Angiomyolipoma (morphologic abnormality)
Synonym: Angiomyolipoma [Disease/Finding]
Synonym: Angiomyolipomas
Synonym: angiomyolipomas
Tree Number: T10.2.3.1.13
database_cross_reference: CHV:0000020982
database_cross_reference: DO:DOID:3314
database_cross_reference: ICD10AM:M8860/0
database_cross_reference: MDR:10051810
database_cross_reference: MSH:D018207
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3734
database_cross_reference: NCI_NCI-GLOSS:CDR0000443027
database_cross_reference: NDFRT:N0000003681
database_cross_reference: PDQ:CDR0000441219
database_cross_reference: RCD:BBJB0
database_cross_reference: SNM:M-8860/0
database_cross_reference: SNMI:M-88600
database_cross_reference: SNOMEDCT_US:19929002

lipoma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that is composed of lipocytes.
PMOID: PMO:00027394
Subclass_of: cell type benign neoplasm
Synonym: Fatty Tumor
Synonym: Fatty Tumors
Synonym: LIPOMA
Synonym: LIPOMA, BENIGN
Synonym: LIPOMATOSIS, FAMILIAL MULTIPLE
Synonym: Lipoma
Synonym: Lipoma (clinical)
Synonym: Lipoma (disorder)
Synonym: Lipoma NOS
Synonym: Lipoma NOS (disorder)
Tree Number: T10.2.3.1.9
database_cross_reference: BI:BI00600
database_cross_reference: CCPSS:1011468
database_cross_reference: CHV:0000007464
database_cross_reference: COSTAR:454
database_cross_reference: CSP:0729-5644
database_cross_reference: CSP:2008-3809
database_cross_reference: CST:NEOPL
database_cross_reference: DO:DOID:3315
database_cross_reference: HPO:HP:0001012
database_cross_reference: HPO:HP:0012032
database_cross_reference: ICD10AM:M8850/0
database_cross_reference: ICD10CM:D17.9
database_cross_reference: ICD9CM:214
database_cross_reference: ICD9CM:214.9
database_cross_reference: ICPC2EENG:S78
database_cross_reference: LNC:LA26514-2
database_cross_reference: MDR:10024612
database_cross_reference: MDR:10024615
database_cross_reference: MDR:10024623
database_cross_reference: MSH:D008067
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3192
database_cross_reference: NCI_CDISC:C3192
database_cross_reference: NCI_NCI-GLOSS:CDR0000454795
database_cross_reference: NCI_NICHD:C3192
database_cross_reference: NDFRT:N0000001854
database_cross_reference: OMIM:MTHU015909
database_cross_reference: OMIM:MTHU016136
database_cross_reference: RCD:B74..
database_cross_reference: RCD:B74z.
database_cross_reference: RCD:BBJ0.
database_cross_reference: RCDSY:BBJ0.
database_cross_reference: SNM:M-8850/0
database_cross_reference: SNMI:D1-F2800
database_cross_reference: SNMI:M-88500
database_cross_reference: SNOMEDCT_US:154612003
database_cross_reference: SNOMEDCT_US:189018005
database_cross_reference: SNOMEDCT_US:189776008
database_cross_reference: SNOMEDCT_US:46720004
database_cross_reference: SNOMEDCT_US:93163002

mood disorder
type: Class
subclass of: cognitive disorder
definition: A cognitive disorder that involves an excessive, irrational dread of everyday situations.
PMOID: PMO:00028196
Subclass_of: cognitive disorder
Synonym: 9-50 UNSPECIFIED MOOD DISORDERS
Synonym: AFFECTIVE DIS
Synonym: AFFECTIVE DISORDER
Synonym: Affecive disorder NOS
Synonym: Affective Disorder
Synonym: Affective Disorders
Synonym: Affective Disturbances
Synonym: Affective disorder
Synonym: Affective disorder NOS
Synonym: Affective disorders
Tree Number: T10.3.12.2
database_cross_reference: CCPSS:0055622
database_cross_reference: CHV:0000038395
database_cross_reference: CHV:0000050546
database_cross_reference: COSTAR:032
database_cross_reference: CSP:2483-6677
database_cross_reference: DO:DOID:3324
database_cross_reference: ICD10:F30-F39.9
database_cross_reference: ICD10:F39
database_cross_reference: ICD10AM:F30-F39.9
database_cross_reference: ICD10AM:F39
database_cross_reference: ICD10CM:F30-F39
database_cross_reference: ICD10CM:F39
database_cross_reference: ICPC2P:P76006
database_cross_reference: LCH:U000094
database_cross_reference: LCH_NW:sh85001494
database_cross_reference: MDR:10001437
database_cross_reference: MDR:10001443
database_cross_reference: MDR:10001444
database_cross_reference: MDR:10001445
database_cross_reference: MDR:10027945
database_cross_reference: MEDCIN:353784
database_cross_reference: MEDLINEPLUS:6063
database_cross_reference: MSH:D019964
database_cross_reference: MTH:439
database_cross_reference: MTHICD9:296.90
database_cross_reference: NCI:C92200
database_cross_reference: NDFRT:N0000003975
database_cross_reference: OMIM:MTHU018691
database_cross_reference: PSY:01255
database_cross_reference: PSY:01260
database_cross_reference: PSY:31975
database_cross_reference: RCD:XE1Xy
database_cross_reference: RCD:XE1Zi
database_cross_reference: RCDSY:XE1Zi
database_cross_reference: SNMI:D9-50000
database_cross_reference: SNMI:F-92110
database_cross_reference: SNOMEDCT_US:192348001
database_cross_reference: SNOMEDCT_US:192391006
database_cross_reference: SNOMEDCT_US:268713007
database_cross_reference: SNOMEDCT_US:46206005
database_cross_reference: SNOMEDCT_US:74421008

histrionic personality disorder
type: Class
subclass of: personality disorder
definition: A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood.
PMOID: PMO:00027901
Subclass_of: personality disorder
Synonym: Disorder, Histrionic Personality
Synonym: Disorders, Histrionic Personality
Synonym: HISTRIONIC PERSONALITY DIS
Synonym: HYSTERICAL PERSONALITY
Synonym: Histionic personality disorder
Synonym: Histrionic Personality Disorder
Synonym: Histrionic Personality Disorder [Disease/Finding]
Synonym: Histrionic Personality Disorders
Synonym: Histrionic person NOS
Synonym: Histrionic personality
Tree Number: T10.3.2.3
database_cross_reference: AOD:0000006665
database_cross_reference: CCPSS:0048558
database_cross_reference: CCPSS:0052430
database_cross_reference: CHV:0000006184
database_cross_reference: COSTAR:405
database_cross_reference: DO:DOID:334
database_cross_reference: DSM-5:301.50
database_cross_reference: DSM-5:F60.4
database_cross_reference: HPO:HP:0012077
database_cross_reference: ICD10:F60.4
database_cross_reference: ICD10AM:F60.4
database_cross_reference: ICD10CM:F60.4
database_cross_reference: ICD9CM:301.5
database_cross_reference: ICD9CM:301.50
database_cross_reference: MDR:10020120
database_cross_reference: MDR:10020154
database_cross_reference: MDR:10020155
database_cross_reference: MDR:10020156
database_cross_reference: MDR:10021164
database_cross_reference: MDR:10021165
database_cross_reference: MEDCIN:32850
database_cross_reference: MSH:D006677
database_cross_reference: MTHICD9:301.50
database_cross_reference: NCI:C92634
database_cross_reference: NDFRT:N0000001547
database_cross_reference: PSY:23082
database_cross_reference: PSY:24230
database_cross_reference: RCD:E215.
database_cross_reference: RCD:E2150
database_cross_reference: RCD:E215z
database_cross_reference: SNM:F-93580
database_cross_reference: SNM:F-93600
database_cross_reference: SNMI:D9-62300
database_cross_reference: SNOMEDCT_US:154900000
database_cross_reference: SNOMEDCT_US:191764009
database_cross_reference: SNOMEDCT_US:191767002
database_cross_reference: SNOMEDCT_US:192489002
database_cross_reference: SNOMEDCT_US:268758001
database_cross_reference: SNOMEDCT_US:55341008

glycoproteinosis
type: Class
subclass of: lysosomal storage disease
definition: A lysosomal storage disease that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase).
PMOID: PMO:00029113
Subclass_of: lysosomal storage disease
Synonym: Mucolipidoses
Synonym: Mucolipidoses [Disease/Finding]
Synonym: Mucolipidosis
Synonym: Mucolipidosis (disorder)
Synonym: Mucolipidosis type I
Synonym: Mucolipidosis, NOS
Synonym: Sialidoses
Synonym: Sialidosis
Synonym: mucolipidoses
Synonym: mucolipidosis
Tree Number: T10.6.2.8.10
database_cross_reference: CHV:0000008306
database_cross_reference: DO:DOID:3343
database_cross_reference: MDR:10072939
database_cross_reference: MEDCIN:273574
database_cross_reference: MEDLINEPLUS:1703
database_cross_reference: MSH:D009081
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C61267
database_cross_reference: NDFRT:N0000002043
database_cross_reference: SNM:D-1462
database_cross_reference: SNMI:D6-70010
database_cross_reference: SNOMEDCT_US:70528007

mesenchymal cell neoplasm
type: Class
subclass of: cell type cancer
definition: A cell type cancer that has material basis in abnormally proliferating cells derives from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.
PMOID: PMO:00025253
Subclass_of: cell type cancer
Synonym: Benign Soft Tissue Neoplasm of Uncertain Differentiation
Synonym: Benign Soft Tissue Tumor of Uncertain Differentiation
Synonym: benign miscellaneous mesenchymal tumor
Synonym: mesenchymal tumor
Tree Number: T10.2.1.1.1
database_cross_reference: DO:DOID:3350
database_cross_reference: NCI:C6587

inappropriate ADH syndrome
type: Class
subclass of: pituitary gland disease
PMOID: PMO:00033224
Subclass_of: pituitary gland disease
Synonym: ADH INAPPROPRIATE
Synonym: ADH INAPPROPRIATE SECRETION
Synonym: ADH Syndrome, Inappropriate
Synonym: ADH inappropriate
Synonym: ADH inappropriate secretion
Synonym: ANTIDIURETIC HORMONE INAPPROPRIATE SECRET
Synonym: Antidiuretic Hormone, Inappropriate Secretion
Synonym: INAPPROPRIATE ADH
Synonym: INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE
Synonym: INAPPROPRIATE VASOPRESSIN SECRET SYNDROME
Tree Number: T10.8.8.5.5
database_cross_reference: AOD:0000005977
database_cross_reference: CCPSS:0019261
database_cross_reference: CHV:0000006634
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000576
database_cross_reference: CST:ADH INAPPROP
database_cross_reference: CST:METSIADH
database_cross_reference: DO:DOID:3401
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000930
database_cross_reference: HPO:HP:0031218
database_cross_reference: ICD10:E22.2
database_cross_reference: ICD10AM:E22.2
database_cross_reference: ICD10CM:E22.2
database_cross_reference: MDR:10001270
database_cross_reference: MDR:10001271
database_cross_reference: MDR:10021585
database_cross_reference: MDR:10021586
database_cross_reference: MDR:10021587
database_cross_reference: MDR:10021598
database_cross_reference: MDR:10040626
database_cross_reference: MDR:10042818
database_cross_reference: MDR:10042828
database_cross_reference: MDR:10053198
database_cross_reference: MDR:10071644
database_cross_reference: MEDCIN:30590
database_cross_reference: MSH:D007177
database_cross_reference: MTHICD9:253.6
database_cross_reference: NCI:C3988
database_cross_reference: NCI_NICHD:C3988
database_cross_reference: NDFRT:N0000001674
database_cross_reference: OMIM:MTHU016053
database_cross_reference: RCD:C1360
database_cross_reference: SNM:D-2102
database_cross_reference: SNMI:DB-13200
database_cross_reference: SNOMEDCT_US:389983008
database_cross_reference: SNOMEDCT_US:55004003

histiocytosis
type: Class
subclass of: lymphatic system disease
definition: A lymphatic system disease that is characterized by an excessive number of histiocytes.
PMOID: PMO:00032930
Subclass_of: lymphatic system disease
Synonym: 778 HISTIOCYTOSES
Synonym: HISTIOCYTOSES
Synonym: Hand Schuller Christian disease
Synonym: Histiocytic Infiltrate
Synonym: Histiocytic Syndrome
Synonym: Histiocytic infiltrate
Synonym: Histiocytic infiltrate (morphologic abnormality)
Synonym: Histiocytic infiltrate, NOS
Synonym: Histiocytic reaction
Synonym: Histiocytic reaction, NOS
Tree Number: T10.8.6.4.5
database_cross_reference: CHV:0000006164
database_cross_reference: DO:DOID:3405
database_cross_reference: HPO:HP:0100727
database_cross_reference: MDR:10020117
database_cross_reference: MDR:10020118
database_cross_reference: MEDCIN:31813
database_cross_reference: MSH:D015614
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.89
database_cross_reference: NCI:C3106
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NICHD:C3106
database_cross_reference: NDFRT:N0000003294
database_cross_reference: RCD:C37y7
database_cross_reference: SNM:M-47180
database_cross_reference: SNM:M-77800
database_cross_reference: SNM:U000387
database_cross_reference: SNMI:M-43070
database_cross_reference: SNMI:M-77800
database_cross_reference: SNOMEDCT_US:190957008
database_cross_reference: SNOMEDCT_US:60657004
database_cross_reference: SNOMEDCT_US:65396000

peripheral vascular disease
type: Class
subclass of: vascular disease
definition: A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.
PMOID: PMO:00031842
Subclass_of: vascular disease
Synonym: ARTERIAL OBSTRUCTIVE DIS
Synonym: ARTERIAL OCCLUSIVE DIS
Synonym: Arterial Obstructive Disease
Synonym: Arterial Obstructive Diseases
Synonym: Arterial Occlusive Disease
Synonym: Arterial Occlusive Diseases
Synonym: Arterial Occlusive Diseases [Disease/Finding]
Synonym: Arterial occlusive disease
Synonym: Disease, Arterial Obstructive
Synonym: Disease, Arterial Occlusive
Tree Number: T10.8.3.3.5
database_cross_reference: CHV:0000001452
database_cross_reference: DO:DOID:341
database_cross_reference: MDR:10062599
database_cross_reference: MSH:D001157
database_cross_reference: MTH:071
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000471
database_cross_reference: SNMI:D3-81900
database_cross_reference: SNOMEDCT_US:2929001

alpha-mannosidosis
type: Class
subclass of: lysosomal storage disease
definition: A lysosomal storage disease that has_material_basis_in deficiency of the alpha-D-manosidase enzyme resulting in the impairment of cell function from a build up of complex sugars derived from glycoproteins in the lysosome.
PMOID: PMO:00029048
Subclass_of: lysosomal storage disease
Synonym: ALPHA-MANNOSIDASE B DEFICIENCY
Synonym: ALPHA-MANNOSIDOSIS
Synonym: Alpha-D-Mannosidosis
Synonym: Alpha-D-mannosidosis
Synonym: Alpha-Mannosidase B Deficiency
Synonym: Alpha-Mannosidosis
Synonym: Alpha-Mannosidosis, Type I
Synonym: Alpha-mannosidase deficiency
Synonym: Deficiencies, Lysosomal alpha-D-Mannosidase
Synonym: Deficiencies, alpha-Mannosidase
Tree Number: T10.6.2.8.1
database_cross_reference: CHV:0000007733
database_cross_reference: DO:DOID:3413
database_cross_reference: MSH:D008363
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84548
database_cross_reference: NDFRT:N0000001940
database_cross_reference: OMIM:248500
database_cross_reference: OMIM:609458
database_cross_reference: RCD:C31y3
database_cross_reference: SNMI:D6-72400
database_cross_reference: SNOMEDCT_US:124466001
database_cross_reference: SNOMEDCT_US:65524005

uterine disease
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is located_in the uterus.
PMOID: PMO:00029842
Subclass_of: female reproductive system disease
Synonym: DISORDER UTERINE (NOS)
Synonym: Disease of uterus
Synonym: Disease of uterus (disorder)
Synonym: Disease of uterus, NOS
Synonym: Disease or syndrome of uterus
Synonym: Disease, Uterine
Synonym: Diseases, Uterine
Synonym: Disorder of uterus
Synonym: Disorder of uterus (disorder)
Synonym: Disorder of uterus NOS
Tree Number: T10.8.1.4.19
database_cross_reference: CHV:0000012819
database_cross_reference: CSP:2587-6184
database_cross_reference: CST:UG/FG/UTRS
database_cross_reference: CST:UTER DIS
database_cross_reference: DO:DOID:345
database_cross_reference: ICD10CM:N85.9
database_cross_reference: ICD9CM:621.9
database_cross_reference: LCH_NW:sh85141611
database_cross_reference: MDR:10013280
database_cross_reference: MDR:10045837
database_cross_reference: MDR:10046779
database_cross_reference: MDR:10046781
database_cross_reference: MDR:10048531
database_cross_reference: MEDCIN:34230
database_cross_reference: MEDLINEPLUS:477
database_cross_reference: MSH:D014591
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26907
database_cross_reference: NDFRT:N0000003090
database_cross_reference: RCD:K54z.
database_cross_reference: RCD:X4073
database_cross_reference: SNM:D-2460
database_cross_reference: SNMI:D7-70020
database_cross_reference: SNOMEDCT_US:12337004
database_cross_reference: SNOMEDCT_US:156004005
database_cross_reference: SNOMEDCT_US:156009000
database_cross_reference: SNOMEDCT_US:198335006
database_cross_reference: SNOMEDCT_US:237068005

breast disease
type: Class
subclass of: thoracic disease
definition: A thoracic disease that is located_in the breast.
PMOID: PMO:00033247
Subclass_of: thoracic disease
Synonym: BREAST DIS
Synonym: BREAST DISEASE
Synonym: BREAST DISORDER
Synonym: BREAST DISORDERS
Synonym: Breast Disease
Synonym: Breast Diseases
Synonym: Breast Diseases [Disease/Finding]
Synonym: Breast Disorder
Synonym: Breast disease
Synonym: Breast disorder
Tree Number: T10.8.9.1
database_cross_reference: CCPSS:0052018
database_cross_reference: CHV:0000002154
database_cross_reference: COSTAR:U000089
database_cross_reference: CSP:2587-5865
database_cross_reference: CST:GENBREAST
database_cross_reference: DO:DOID:3463
database_cross_reference: ICD10:N60-N64.9
database_cross_reference: ICD10:N64.9
database_cross_reference: ICD10AM:N60-N64.9
database_cross_reference: ICD10AM:N64.9
database_cross_reference: ICD10CM:N60-N65
database_cross_reference: ICD10CM:N64.9
database_cross_reference: ICD9CM:610-612.99
database_cross_reference: ICD9CM:611.9
database_cross_reference: LCH_NW:sh85016683
database_cross_reference: MDR:10006231
database_cross_reference: MDR:10006232
database_cross_reference: MDR:10045645
database_cross_reference: MDR:10058702
database_cross_reference: MDR:10061021
database_cross_reference: MEDCIN:39997
database_cross_reference: MEDLINEPLUS:474
database_cross_reference: MSH:D001941
database_cross_reference: MTH:121
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26709
database_cross_reference: NDFRT:N0000000611
database_cross_reference: RCD:K3...
database_cross_reference: RCD:K3z..
database_cross_reference: SNM:D-2750
database_cross_reference: SNM:U000005
database_cross_reference: SNMI:D7-90000
database_cross_reference: SNOMEDCT_US:155946009
database_cross_reference: SNOMEDCT_US:155962003
database_cross_reference: SNOMEDCT_US:155966000
database_cross_reference: SNOMEDCT_US:198129001
database_cross_reference: SNOMEDCT_US:198566004
database_cross_reference: SNOMEDCT_US:266647006
database_cross_reference: SNOMEDCT_US:79604008

plague
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.
PMOID: PMO:00029523
Subclass_of: primary bacterial infectious disease
Synonym: Infection by Yersinia pestis
Synonym: Pest
Synonym: Pestilential fever
Synonym: Plague
Synonym: Plague (disorder)
Synonym: Plague NOS
Synonym: Plague [Disease/Finding]
Synonym: Plague unspecified
Synonym: Plague unspecified (disorder)
Synonym: Plague, NOS
Tree Number: T10.7.3.1.21
database_cross_reference: CHV:0000009787
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0368-3331
database_cross_reference: DO:DOID:3482
database_cross_reference: ICD10:A20
database_cross_reference: ICD10:A20.9
database_cross_reference: ICD10AM:A20
database_cross_reference: ICD10AM:A20.9
database_cross_reference: ICD10CM:A20
database_cross_reference: ICD10CM:A20.9
database_cross_reference: ICD9CM:020
database_cross_reference: ICD9CM:020.9
database_cross_reference: ICPC2P:A78020
database_cross_reference: LCH:U003698
database_cross_reference: LCH_NW:sh85102591
database_cross_reference: LNC:LA10495-2
database_cross_reference: MDR:10035148
database_cross_reference: MDR:10035149
database_cross_reference: MDR:10046098
database_cross_reference: MDR:10048250
database_cross_reference: MEDCIN:31027
database_cross_reference: MEDCIN:97368
database_cross_reference: MEDLINEPLUS:1656
database_cross_reference: MSH:D010930
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85015
database_cross_reference: NCI_NICHD:C85015
database_cross_reference: NDFRT:N0000002415
database_cross_reference: RCD:A20..
database_cross_reference: RCD:A20z.
database_cross_reference: SNM:D-0162
database_cross_reference: SNMI:DE-13410
database_cross_reference: SNOMEDCT_US:186290009
database_cross_reference: SNOMEDCT_US:187298009
database_cross_reference: SNOMEDCT_US:58750007

necrobiosis lipoidica
type: Class
subclass of: skin disease
PMOID: PMO:00033983
Subclass_of: skin disease
Synonym: Lipoidica necrobiosis
Synonym: NLD - Necrobiosis lipoidica
Synonym: Necrobiosis Lipoidica
Synonym: Necrobiosis Lipoidica [Disease/Finding]
Synonym: Necrobiosis lipoidica
Synonym: Necrobiosis lipoidica (disorder)
Synonym: Necrobiosis lipoidica, NOS
Synonym: lipoidica necrobiosis nld
Synonym: necrobiosis lipoidica (diagnosis)
Tree Number: T10.8.12.2.47
database_cross_reference: CHV:0000008536
database_cross_reference: DO:DOID:3486
database_cross_reference: MDR:10028847
database_cross_reference: MEDCIN:336161
database_cross_reference: MSH:D009335
database_cross_reference: NCI:C34840
database_cross_reference: NDFRT:N0000002116
database_cross_reference: RCD:X5085
database_cross_reference: SNM:M-44930
database_cross_reference: SNMI:D0-90340
database_cross_reference: SNOMEDCT_US:156394009
database_cross_reference: SNOMEDCT_US:201317009
database_cross_reference: SNOMEDCT_US:201319007
database_cross_reference: SNOMEDCT_US:9418005

cellulitis
type: Class
subclass of: skin disease
definition: A skin disease where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.
PMOID: PMO:00033958
Subclass_of: skin disease
Synonym: CELLULITIS
Synonym: Cellulitis
Synonym: Cellulitis (disorder)
Synonym: Cellulitis (morphologic abnormality)
Synonym: Cellulitis NOS
Synonym: Cellulitis NOS (disorder)
Synonym: Cellulitis [Disease/Finding]
Synonym: Cellulitis, NOS
Synonym: Cellulitis, unspecified
Synonym: Inflammation of subcutaneous tissue
Tree Number: T10.8.12.2.39
database_cross_reference: AOD:0000023000
database_cross_reference: CCPSS:1017421
database_cross_reference: CHV:0000002607
database_cross_reference: COSTAR:163
database_cross_reference: CSP:0729-7208
database_cross_reference: CSP:0944-6244
database_cross_reference: CST:CELLULITIS
database_cross_reference: DO:DOID:3488
database_cross_reference: DXP:U000311
database_cross_reference: DXP:U000578
database_cross_reference: HPO:HP:0100658
database_cross_reference: ICD10:L03
database_cross_reference: ICD10:L03.9
database_cross_reference: ICD10AM:L03
database_cross_reference: ICD10AM:L03.9
database_cross_reference: ICD10CM:L03.90
database_cross_reference: ICPC2P:S10002
database_cross_reference: ICPC2P:S76005
database_cross_reference: LCH:U000875
database_cross_reference: LCH_NW:sh85021701
database_cross_reference: MDR:10007882
database_cross_reference: MEDCIN:30907
database_cross_reference: MEDLINEPLUS:1227
database_cross_reference: MSH:D002481
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:682.9
database_cross_reference: NCI:C26715
database_cross_reference: NCI_FDA:1768
database_cross_reference: NCI_NCI-GLOSS:CDR0000044789
database_cross_reference: NCI_NICHD:C26715
database_cross_reference: NDFRT:N0000000707
database_cross_reference: OMIM:MTHU034281
database_cross_reference: RCD:M03z0
database_cross_reference: SNM:M-40200
database_cross_reference: SNMI:M-41650
database_cross_reference: SNOMEDCT_US:128045006
database_cross_reference: SNOMEDCT_US:156317003
database_cross_reference: SNOMEDCT_US:191132005
database_cross_reference: SNOMEDCT_US:200693005
database_cross_reference: SNOMEDCT_US:385627004
database_cross_reference: SNOMEDCT_US:74276003
database_cross_reference: SNOMEDCT_VET:128045006

Noonan syndrome
type: Class
subclass of: syndrome
definition: A Noonan syndrome that has_material_basis_in the PTPN11 gene on chromosome 12q24.
PMOID: PMO:00025204
Subclass_of: syndrome
Synonym: Familial Turner Syndrome
Synonym: NOONAN SYNDROME
Synonym: NOONAN SYNDROME 1
Synonym: NS1
Synonym: Noonan Ehmke Syndrome
Synonym: Noonan Syndrome
Synonym: Noonan Syndrome 1
Synonym: Noonan Syndrome [Disease/Finding]
Synonym: Noonan syndrome (disorder)
Synonym: Noonan syndrome 1
Tree Number: T10.1.82
database_cross_reference: CCPSS:0057183
database_cross_reference: CHV:0000008767
database_cross_reference: DO:DOID:0060578
database_cross_reference: DO:DOID:3490
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001304
database_cross_reference: ICD10CM:Q87.1
database_cross_reference: JABL:487
database_cross_reference: MDR:10029748
database_cross_reference: MEDCIN:33272
database_cross_reference: MSH:D009634
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34854
database_cross_reference: NCI:C75459
database_cross_reference: NCI_NICHD:C34854
database_cross_reference: NDFRT:N0000002192
database_cross_reference: OMIM:163950
database_cross_reference: OMIM:176876
database_cross_reference: RCD:PJ630
database_cross_reference: RCD:PKy80
database_cross_reference: SNM:D-5354
database_cross_reference: SNMI:D4-00302
database_cross_reference: SNOMEDCT_US:205684007
database_cross_reference: SNOMEDCT_US:205794007
database_cross_reference: SNOMEDCT_US:205824006
database_cross_reference: SNOMEDCT_US:88327006

mastocytosis
type: Class
subclass of: leukocyte disease
PMOID: PMO:00033399
Subclass_of: leukocyte disease
Synonym: Disease, Mast-Cell
Synonym: Diseases, Mast-Cell
Synonym: MAST CELL DIS
Synonym: MAST CELL DISEASE
Synonym: MASTOCYTOSIS
Synonym: Mast Cell Disease
Synonym: Mast cell disease
Synonym: Mast cell disorder
Synonym: Mast cell disorder (disorder)
Synonym: Mast cell hyperplasia
Tree Number: T10.8.10.6.4
database_cross_reference: CCPSS:0046697
database_cross_reference: CHV:0000007789
database_cross_reference: CHV:0000012811
database_cross_reference: CHV:0000057638
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:4006-0061
database_cross_reference: DO:DOID:350
database_cross_reference: HPO:HP:0100495
database_cross_reference: ICD10:Q82.2
database_cross_reference: ICD10AM:Q82.2
database_cross_reference: ICD10CM:Q82.2
database_cross_reference: LCH_NW:sh85081981
database_cross_reference: MDR:10026891
database_cross_reference: MEDCIN:331149
database_cross_reference: MSH:D008415
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84269
database_cross_reference: NDFRT:N0000001949
database_cross_reference: OMIM:154800
database_cross_reference: RCD:PH321
database_cross_reference: SNOMEDCT_US:125541005
database_cross_reference: SNOMEDCT_US:397007003
database_cross_reference: SNOMEDCT_US:78745000

stricture or kinking of ureter
type: Class
subclass of: kidney disease
PMOID: PMO:00033084
Subclass_of: kidney disease
Synonym: Stricture of ureter
Synonym: Stricture or kinking of ureter
Tree Number: T10.8.7.9.25
database_cross_reference: DO:DOID:3508
database_cross_reference: ICD9CM:593.3
database_cross_reference: MDR:10042240
database_cross_reference: MTH:NOCODE

toxic encephalopathy
type: Class
subclass of: nervous system disease
definition: A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems.
PMOID: PMO:00030169
Subclass_of: nervous system disease
Synonym: neurotoxicity
Synonym: neurotoxicity syndrome
Tree Number: T10.8.2.8
database_cross_reference: DO:DOID:3602

beta-mannosidosis
type: Class
subclass of: lysosomal storage disease
definition: A lysosomal storage disease that has_material_basis_in deficiency of the beta-A-manosidase enzyme resulting in the disruption of N-linked glycoprotein oligosaccharide catabolism.
PMOID: PMO:00029059
Subclass_of: lysosomal storage disease
Synonym: BETA MANNOSIDASE DEFIC
Synonym: BETA-MANNOSIDASE DEFICIENCY
Synonym: BETA-MANNOSIDOSIS
Synonym: Beta-D-mannosidosis
Synonym: Beta-D-mannosidosis (disorder)
Synonym: Beta-Mannosidosis
Synonym: Beta-mannosidase deficiency
Synonym: LYSOSOMAL BETA-MANNOSIDASE DEFICIENCY
Synonym: Lysosomal beta A Mannosidosis
Synonym: Lysosomal beta Mannosidase Deficiency
Tree Number: T10.6.2.8.4
database_cross_reference: CHV:0000030796
database_cross_reference: DO:DOID:3633
database_cross_reference: MSH:D044905
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84596
database_cross_reference: NDFRT:N0000011047
database_cross_reference: OMIM:248510
database_cross_reference: OMIM:609489
database_cross_reference: RCD:X40WG
database_cross_reference: SNOMEDCT_US:238047006

empty sella syndrome
type: Class
subclass of: pituitary gland disease
PMOID: PMO:00033222
Subclass_of: pituitary gland disease
Synonym: EMPTY SELLA
Synonym: EMPTY SELLA SYNDROME
Synonym: EMPTY SELLA TURCICA
Synonym: Empty Sella Syndrome
Synonym: Empty Sella Syndrome [Disease/Finding]
Synonym: Empty Sella Syndromes
Synonym: Empty Sella Turcica
Synonym: Empty Sella Turcica Syndrome
Synonym: Empty Sella Turcicas
Synonym: Empty sella syndrome
Tree Number: T10.8.8.5.3
database_cross_reference: CCPSS:1010132
database_cross_reference: CHV:0000004404
database_cross_reference: COSTAR:U000224
database_cross_reference: COSTAR:U000225
database_cross_reference: DO:DOID:3642
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000526
database_cross_reference: MDR:10014567
database_cross_reference: MEDCIN:30495
database_cross_reference: MSH:D004652
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84686
database_cross_reference: NDFRT:N0000001073
database_cross_reference: OMIM:MTHU024846
database_cross_reference: RCD:X40Li
database_cross_reference: SNM:D-2135
database_cross_reference: SNOMEDCT_US:190489005
database_cross_reference: SNOMEDCT_US:237722004
database_cross_reference: SNOMEDCT_US:393569006

necrosis of pituitary
type: Class
subclass of: pituitary gland disease
PMOID: PMO:00033225
Subclass_of: pituitary gland disease
Synonym: NECROSIS PITUITARY
Synonym: Necrosis of pituitary
Synonym: Necrosis of pituitary (disorder)
Synonym: Necrosis of pituitary, NOS
Synonym: Necrosis pituitary
Synonym: Pituitary Gland Necrosis
Synonym: Pituitary Necrosis
Synonym: Pituitary necrosis
Synonym: necrosis of pituitary gland
Synonym: necrosis of pituitary gland (diagnosis)
Tree Number: T10.8.8.5.6
database_cross_reference: CST:NECRO
database_cross_reference: DO:DOID:3646
database_cross_reference: MDR:10028877
database_cross_reference: MEDCIN:359734
database_cross_reference: MTHICD9:253.2
database_cross_reference: NCI:C27066
database_cross_reference: SNMI:DB-12110
database_cross_reference: SNOMEDCT_US:59572000

pyruvate decarboxylase deficiency
type: Class
subclass of: carbohydrate metabolic disorder
definition: A carbohydrate metabolic disorder characterized by the buildup of lactic acid in the body and a variety of neurological problems and caused by a deficiency of one of the three enzymes in the pyruvate dehydrogenase complex.
PMOID: PMO:00029150
Subclass_of: carbohydrate metabolic disorder
Synonym: ATAXIA, INTERMITTENT, WITH ABNORMAL PYRUVATE METABOLISM
Synonym: ATAXIA, INTERMITTENT, WITH PYRUVATE DEHYDROGENASE DEFICIENCY
Synonym: Ataxia with lactic acidosis
Synonym: Ataxia with lactic acidosis I
Synonym: Ataxia, Intermittent, with Abnormal Pyruvate Metabolism
Synonym: Ataxia, Intermittent, with Pyruvate Dehydrogenase, or Decarboxylase, Deficiency
Synonym: Deficiency of alpha-carboxylase
Synonym: Deficiency of alpha-ketoacid carboxylase
Synonym: Deficiency of pyruvate decarboxylase
Synonym: Deficiency of pyruvate decarboxylase (disorder)
Tree Number: T10.6.2.11.12
database_cross_reference: DO:DOID:3649
database_cross_reference: ICD10CM:E74.4
database_cross_reference: JABL:548
database_cross_reference: MSH:D015325
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C103968
database_cross_reference: NCI_NICHD:C103968
database_cross_reference: NDFRT:N0000003222
database_cross_reference: OMIM:312170
database_cross_reference: RCD:X40Tw
database_cross_reference: SNMI:D6-58100
database_cross_reference: SNOMEDCT_US:124160001
database_cross_reference: SNOMEDCT_US:124593001
database_cross_reference: SNOMEDCT_US:190761008
database_cross_reference: SNOMEDCT_US:46683007

bladder disease
type: Class
subclass of: urinary system disease
definition: A urinary system disease that is located_in the bladder.
PMOID: PMO:00033087
Subclass_of: urinary system disease
Synonym: 7-21 DISEASES OF THE BLADDER
Synonym: BLADDER DIS
Synonym: BLADDER DISORDER
Synonym: Bladder Disease
Synonym: Bladder Diseases
Synonym: Bladder Disorder
Synonym: Bladder Disorders
Synonym: Bladder disease or syndrome
Synonym: Bladder disorder
Synonym: Bladder disorder NOS
Tree Number: T10.8.7.11
database_cross_reference: CCPSS:0014180
database_cross_reference: CHV:0000001951
database_cross_reference: CSP:3045-9024
database_cross_reference: CST:UG/UT/B
database_cross_reference: DO:DOID:365
database_cross_reference: ICD10:N32.9
database_cross_reference: ICD10AM:N32.9
database_cross_reference: ICD10CM:N32.9
database_cross_reference: ICD9CM:596.9
database_cross_reference: LCH_NW:sh85014727
database_cross_reference: MDR:10005035
database_cross_reference: MDR:10045774
database_cross_reference: MDR:10061011
database_cross_reference: MEDCIN:95369
database_cross_reference: MEDLINEPLUS:164
database_cross_reference: MSH:D001745
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2900
database_cross_reference: NCI_NICHD:C2900
database_cross_reference: NDFRT:N0000000560
database_cross_reference: RCD:K16z.
database_cross_reference: RCD:X30NT
database_cross_reference: SNM:D-6810
database_cross_reference: SNMI:D7-21000
database_cross_reference: SNOMEDCT_US:155886002
database_cross_reference: SNOMEDCT_US:155890000
database_cross_reference: SNOMEDCT_US:197897007
database_cross_reference: SNOMEDCT_US:266630005
database_cross_reference: SNOMEDCT_US:42643001

lactic acidosis
type: Class
subclass of: metabolic acidosis
definition: A metabolic acidosis characterized by buildup of lactate.
PMOID: PMO:00028841
Subclass_of: metabolic acidosis
Synonym: ACIDOSIS LACTIC
Synonym: Acidosis lactic
Synonym: Acidosis, Lactic
Synonym: Acidosis, Lactic [Disease/Finding]
Synonym: LACTIC ACIDOSIS
Synonym: Lactic Acidosis
Synonym: Lactic acidosis
Synonym: Lactic acidosis (disorder)
Synonym: Lacticacidosis
Synonym: acidosis lactic
Tree Number: T10.6.1.1.1
database_cross_reference: AOD:0000005825
database_cross_reference: AOD:0000023481
database_cross_reference: CCPSS:1006315
database_cross_reference: CHV:0000000635
database_cross_reference: CSP:1849-5394
database_cross_reference: CST:ACIDOSIS LACTIC
database_cross_reference: DO:DOID:3650
database_cross_reference: DXP:U002315
database_cross_reference: HPO:HP:0003128
database_cross_reference: ICD10CM:E87.2
database_cross_reference: MDR:10000491
database_cross_reference: MDR:10023676
database_cross_reference: MEDCIN:30579
database_cross_reference: MSH:D000140
database_cross_reference: MTHICD9:276.2
database_cross_reference: NCI:C98969
database_cross_reference: NCI_NICHD:C98969
database_cross_reference: NDFRT:N0000000284
database_cross_reference: OMIM:MTHU036657
database_cross_reference: RCD:C3622
database_cross_reference: SNM:F-11753
database_cross_reference: SNMI:D6-23300
database_cross_reference: SNOMEDCT_US:91273001

pyruvate carboxylase deficiency disease
type: Class
subclass of: carbohydrate metabolic disorder
PMOID: PMO:00029128
Subclass_of: carbohydrate metabolic disorder
Synonym: ATAXIA WITH LACTIC ACIDOSIS II
Synonym: Ataxia with Lactic Acidosis 2
Synonym: Ataxia with Lactic Acidosis II
Synonym: Ataxia with Lactic Acidosis, Type II
Synonym: Ataxia with lactic acidosis II
Synonym: DEFIC DIS PYRUVATE CARBOXYLASE
Synonym: Deficiency Disease, Pyruvate Carboxylase
Synonym: Deficiency of pyruvate carboxylase
Synonym: Deficiency of pyruvate carboxylase (disorder)
Synonym: Deficiency of pyruvic carboxylase
Tree Number: T10.6.2.11.7
database_cross_reference: DO:DOID:3651
database_cross_reference: DRUGBANK:DB03403
database_cross_reference: ICD10CM:E74.4
database_cross_reference: LNC:LA12519-7
database_cross_reference: MDR:10077944
database_cross_reference: MEDCIN:312759
database_cross_reference: MSH:D015324
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85040
database_cross_reference: NCI_NICHD:C85040
database_cross_reference: NDFRT:N0000003221
database_cross_reference: OMIM:266150
database_cross_reference: OMIM:608786
database_cross_reference: RCD:X40Tv
database_cross_reference: SNMI:D6-58110
database_cross_reference: SNOMEDCT_US:124716008
database_cross_reference: SNOMEDCT_US:87694001

Leigh disease
type: Class
subclass of: mitochondrial metabolism disease
definition: A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity.
PMOID: PMO:00028980
Subclass_of: mitochondrial metabolism disease
Synonym: Disease, Leigh's
Synonym: ENCEPH SUBACUTE NECROTIZING
Synonym: ENCEPHALOMYELOPATHY, NECROTIZING, SUBACUTE
Synonym: Encephalomyelitides, Subacute Necrotizing
Synonym: Encephalomyelitis, Subacute Necrotizing
Synonym: Encephalomyelopathies, Subacute Necrotizing
Synonym: Encephalomyelopathy, Subacute Necrotizing
Synonym: Encephalopathies, Subacute Necrotizing
Synonym: Encephalopathy, Subacute Necrotizing
Synonym: Infantile necrotizing encephalomyelopathy
Tree Number: T10.6.2.1.17
database_cross_reference: CHV:0000007287
database_cross_reference: CSP:1254-7727
database_cross_reference: CSP:1849-5394
database_cross_reference: CSP:5000-0048
database_cross_reference: DO:DOID:3652
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000542
database_cross_reference: ICD10CM:G31.82
database_cross_reference: MDR:10062950
database_cross_reference: MEDCIN:36374
database_cross_reference: MEDCIN:36375
database_cross_reference: MSH:D007888
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:330.8
database_cross_reference: NCI:C84814
database_cross_reference: NCI_NICHD:C84814
database_cross_reference: NDFRT:N0000001801
database_cross_reference: OMIM:256000
database_cross_reference: OMIM:516060
database_cross_reference: OMIM:590060
database_cross_reference: OMIM:590095
database_cross_reference: OMIM:590105
database_cross_reference: OMIM:612360
database_cross_reference: OMIM:MTHU028243
database_cross_reference: OMIM:MTHU039986
database_cross_reference: RCD:F10y1
database_cross_reference: RCDAE:F10y1
database_cross_reference: SNM:D-8744
database_cross_reference: SNMI:DA-20161
database_cross_reference: SNOMEDCT_US:29570005

sialuria
type: Class
subclass of: lysosomal storage disease
definition: A lysosomal storage disease characterized by increased sialic acid in the urine.
PMOID: PMO:00029060
Subclass_of: lysosomal storage disease
Synonym: N-acetylneuraminic acid (NANA) storage disease (NSD)
Synonym: N-acetylneuraminic acid storage disease
Synonym: SIALIC ACID STORAGE DIS
Synonym: SIALURIA
Synonym: Salla Disease
Synonym: Sialic Acid Storage Disease
Synonym: Sialic Acid Storage Disease [Disease/Finding]
Synonym: Sialic acid storage disease
Synonym: Sialuria
Synonym: Sialuria (disorder)
Tree Number: T10.6.2.8.5
database_cross_reference: DO:DOID:3659
database_cross_reference: JABL:571
database_cross_reference: MDR:10067529
database_cross_reference: MSH:D029461
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85067
database_cross_reference: NDFRT:N0000011089
database_cross_reference: OMIM:269921
database_cross_reference: OMIM:603824
database_cross_reference: RCD:X40WO
database_cross_reference: SNOMEDCT_US:238051008

brachial plexus neuropathy
type: Class
subclass of: peripheral nervous system disease
PMOID: PMO:00029892
Subclass_of: peripheral nervous system disease
Synonym: BPN - Brachial plex neuropathy
Synonym: BPN - Brachial plexus neuropathy
Synonym: BRACHIAL PLEXUS DIS
Synonym: BRACHIAL PLEXUS NEUROPATHY
Synonym: Brachial Plexopathy
Synonym: Brachial Plexus Disease
Synonym: Brachial Plexus Diseases
Synonym: Brachial Plexus Disorder
Synonym: Brachial Plexus Disorders
Synonym: Brachial Plexus Neuropathies
Tree Number: T10.8.2.4.3
database_cross_reference: CCPSS:0051136
database_cross_reference: CHV:0000044701
database_cross_reference: DO:DOID:3690
database_cross_reference: HPO:HP:0045054
database_cross_reference: ICD10:G54.0
database_cross_reference: ICD10AM:G54.0
database_cross_reference: ICD10CM:G54.0
database_cross_reference: LCH_NW:sh85016237
database_cross_reference: MDR:10065417
database_cross_reference: MEDCIN:337547
database_cross_reference: MSH:D020516
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C27194
database_cross_reference: NCI_CTCAE:E12601
database_cross_reference: NCI_NCI-GLOSS:CDR0000044493
database_cross_reference: NCI_NICHD:C27194
database_cross_reference: NDFRT:N0000004157
database_cross_reference: RCD:F335.
database_cross_reference: SNM:D-8X70
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DA-42020
database_cross_reference: SNOMEDCT_US:3548001

skin disease
type: Class
subclass of: integumentary system disease
PMOID: PMO:00033771
Subclass_of: integumentary system disease
Synonym: Cutaneous Disorder
Synonym: Cutaneous Disorders
Synonym: Cutaneous disorders
Synonym: DERMATOSIS
Synonym: DERMOPATHY
Synonym: DISORDER SKIN (NOS)
Synonym: Dermatologic disease
Synonym: Dermatologic disorders
Synonym: Dermatological disease
Synonym: Dermatological disorder
Tree Number: T10.8.12.2
database_cross_reference: AOD:0000005186
database_cross_reference: AOD:0000005193
database_cross_reference: AOD:0000023294
database_cross_reference: AOD:0000023295
database_cross_reference: CCPSS:0031801
database_cross_reference: CCPSS:0037239
database_cross_reference: CCPSS:0058680
database_cross_reference: CHV:0000011391
database_cross_reference: CHV:0000047454
database_cross_reference: CSP:2716-5992
database_cross_reference: CSP:2716-7619
database_cross_reference: CST:SKIN
database_cross_reference: CST:SKIN DIS
database_cross_reference: CST:SKIN/DERM
database_cross_reference: HPO:HP:0000951
database_cross_reference: ICPC2P:S99037
database_cross_reference: ICPC2P:S99043
database_cross_reference: LCH_NW:sh85123171
database_cross_reference: LNC:LA17775-0
database_cross_reference: LNC:LP89804-6
database_cross_reference: LNC:MTHU031899
database_cross_reference: MDR:10013267
database_cross_reference: MDR:10040831
database_cross_reference: MDR:10040833
database_cross_reference: MDR:10048528
database_cross_reference: MDR:10048768
database_cross_reference: MEDCIN:34350
database_cross_reference: MEDCIN:98702
database_cross_reference: MEDLINEPLUS:40
database_cross_reference: MSH:D012871
database_cross_reference: MTH:684
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:709.9
database_cross_reference: NCI:C27554
database_cross_reference: NCI:C3371
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NICHD:C3371
database_cross_reference: NDFRT:N0000002761
database_cross_reference: PSY:47740
database_cross_reference: RCD:M....
database_cross_reference: RCD:XE1Ci
database_cross_reference: SNM:D-3500
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D0-00004
database_cross_reference: SNOMEDCT_US:156292006
database_cross_reference: SNOMEDCT_US:156396006
database_cross_reference: SNOMEDCT_US:156400006
database_cross_reference: SNOMEDCT_US:156445005
database_cross_reference: SNOMEDCT_US:200580005
database_cross_reference: SNOMEDCT_US:267859000
database_cross_reference: SNOMEDCT_US:267860005
database_cross_reference: SNOMEDCT_US:267873009
database_cross_reference: SNOMEDCT_US:80659006
database_cross_reference: SNOMEDCT_US:95320005

theileriasis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks.
PMOID: PMO:00029686
Subclass_of: parasitic protozoa infectious disease
Synonym: Infection by Theileria
Synonym: theileriosis
Tree Number: T10.7.4.2.6
database_cross_reference: DO:DOID:3733

nutrition disease
type: Class
subclass of: acquired metabolic disease
definition: An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods.
PMOID: PMO:00028892
Subclass_of: acquired metabolic disease
Synonym: 6-100 NUTRITIONAL DISORDERS: GENERAL TERMS
Synonym: Disease;nutritional
Synonym: Diseases of Nutrition
Synonym: Disorder of nutrition
Synonym: Disorder of nutrition (disorder)
Synonym: Disorder;nutritional
Synonym: NUTRITION DIS
Synonym: NUTRITIONAL DIS
Synonym: NUTRITIONAL DISORDERS
Synonym: NUTRITIONAL DISORDERS: GENERAL TERMS
Tree Number: T10.6.1.4
database_cross_reference: AOD:0000004751
database_cross_reference: CHV:0000008846
database_cross_reference: CHV:0000049637
database_cross_reference: CSP:2116-6840
database_cross_reference: DO:DOID:374
database_cross_reference: ICPC2P:T29005
database_cross_reference: ICPC2P:T91005
database_cross_reference: ICPC2P:T91006
database_cross_reference: ICPC2P:T99054
database_cross_reference: LCH:U003306
database_cross_reference: LCH_NW:sh85093469
database_cross_reference: LNC:LP75258-1
database_cross_reference: LNC:MTHU021184
database_cross_reference: MEDCIN:338590
database_cross_reference: MSH:D009748
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26836
database_cross_reference: NCI_NICHD:C26836
database_cross_reference: NDFRT:N0000002196
database_cross_reference: SNM:D-1010
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D6-10000
database_cross_reference: SNOMEDCT_US:191077005
database_cross_reference: SNOMEDCT_US:2492009

cytochrome-c oxidase deficiency disease
type: Class
subclass of: mitochondrial metabolism disease
PMOID: PMO:00028994
Subclass_of: mitochondrial metabolism disease
Synonym: COX - Cytochrome C oxidase deficiency
Synonym: COX DEFICIENCY
Synonym: COX deficiency
Synonym: COX-Cytochrome C oxidase defic
Synonym: CYTOCHROME C OXIDASE DEFIC
Synonym: CYTOCHROME OXIDASE DEFIC
Synonym: CYTOCHROME c OXIDASE DEFICIENCY
Synonym: Complex IV Deficiencies
Synonym: Complex IV Deficiency
Synonym: Complex IV deficiency
Tree Number: T10.6.2.1.31
database_cross_reference: CHV:0000026279
database_cross_reference: DO:DOID:3762
database_cross_reference: MSH:D030401
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98910
database_cross_reference: NCI_NICHD:C98910
database_cross_reference: NDFRT:N0000011043
database_cross_reference: OMIM:124089
database_cross_reference: OMIM:185620
database_cross_reference: OMIM:220110
database_cross_reference: OMIM:516030
database_cross_reference: OMIM:516040
database_cross_reference: OMIM:516050
database_cross_reference: OMIM:590010
database_cross_reference: OMIM:590050
database_cross_reference: OMIM:602125
database_cross_reference: OMIM:603644
database_cross_reference: OMIM:612958
database_cross_reference: OMIM:614698
database_cross_reference: OMIM:614770
database_cross_reference: OMIM:616003
database_cross_reference: OMIM:MTHU034717
database_cross_reference: OMIM:MTHU039189
database_cross_reference: RCD:X40UB
database_cross_reference: SNMI:D6-72730
database_cross_reference: SNOMEDCT_US:124199009
database_cross_reference: SNOMEDCT_US:237991006
database_cross_reference: SNOMEDCT_US:67434000

Coffin-Lowry syndrome
type: Class
subclass of: X-linked disease
PMOID: PMO:00028733
Subclass_of: X-linked disease
Synonym: CLS
Synonym: CLS - Coffin-Lowry syndrome
Synonym: COFFIN-LOWRY SYNDROME
Synonym: Coffin Lowry Syndrome
Synonym: Coffin Syndrome
Synonym: Coffin syndrome 2
Synonym: Coffin-Lowry Syndrome
Synonym: Coffin-Lowry Syndrome [Disease/Finding]
Synonym: Coffin-Lowry syndrome (CLS)
Synonym: Coffin-Lowry syndrome (diagnosis)
Tree Number: T10.5.3.4.13
database_cross_reference: CHV:0000025867
database_cross_reference: DO:DOID:3783
database_cross_reference: JABL:238
database_cross_reference: MEDCIN:311935
database_cross_reference: MSH:D038921
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84643
database_cross_reference: NDFRT:N0000010973
database_cross_reference: OMIM:300075
database_cross_reference: OMIM:303600
database_cross_reference: RCD:Xa0Zc
database_cross_reference: SNM:D-5122
database_cross_reference: SNMI:D4-00811
database_cross_reference: SNOMEDCT_US:15182000

Crigler-Najjar syndrome
type: Class
subclass of: bilirubin metabolic disorder
definition: A bilirubin metabolic disorder that involves a build up of bilirubin as bilirubin is not being broken down as a result of a lack or deficiency of the enzyme uridine diphosphate glycosyltransferase (UGT).
PMOID: PMO:00028998
Subclass_of: bilirubin metabolic disorder
Synonym: Bil UDP glucurnyl transf defic
Synonym: Bili glucuronosyltra'ase def
Synonym: Bilirubin UDP glucuronyl transferase deficiency
Synonym: Bilirubin UDP glucuronyl transferase deficiency (disorder)
Synonym: Bilirubin glucuronosyltransferase deficiency
Synonym: CRIGLER-NAJJAR DISEASE
Synonym: CRIGLER-NAJJAR SYNDROME
Synonym: CRIGLER-NAJJAR SYNDROME, TYPE I
Synonym: Crigler Najar Syndrome
Synonym: Crigler Najjar Syndrome
Tree Number: T10.6.2.3.2
database_cross_reference: CHV:0000003453
database_cross_reference: CSP:1654-1020
database_cross_reference: DO:DOID:3803
database_cross_reference: DXP:U000420
database_cross_reference: ICD10:E80.5
database_cross_reference: ICD10AM:E80.5
database_cross_reference: ICD10CM:E80.5
database_cross_reference: MDR:10011386
database_cross_reference: MDR:10057034
database_cross_reference: MEDCIN:30130
database_cross_reference: MEDCIN:30131
database_cross_reference: MSH:D003414
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.4
database_cross_reference: NCI:C84656
database_cross_reference: NDFRT:N0000000873
database_cross_reference: OMIM:191740
database_cross_reference: OMIM:218800
database_cross_reference: RCD:C3740
database_cross_reference: RCD:X307h
database_cross_reference: SNM:D-1502
database_cross_reference: SNMI:D6-85200
database_cross_reference: SNMI:D6-85210
database_cross_reference: SNOMEDCT_US:190933008
database_cross_reference: SNOMEDCT_US:28259009
database_cross_reference: SNOMEDCT_US:8933000

Peutz-Jeghers syndrome
type: Class
subclass of: intestinal disease
PMOID: PMO:00033607
Subclass_of: intestinal disease
Synonym: Colonic hamartomatous polyp
Synonym: Hamartomatous Intestinal Polyposes
Synonym: Hamartomatous Intestinal Polyposis
Synonym: INTESTINAL POLYPOSIS-CUTANEOUS PIGMENTATION SYNDROME
Synonym: Intestinal Polyposes, Hamartomatous
Synonym: Intestinal Polyposis, Hamartomatous
Synonym: Jeghers-Peutz Syndrome
Synonym: Lentiginoses, Perioral
Synonym: Lentiginosis, Perioral
Synonym: PEUTZ-JEGHERS SYNDROME
Tree Number: T10.8.11.8.19
database_cross_reference: CHV:0000009562
database_cross_reference: CSP:0944-7801
database_cross_reference: CSP:1248-3971
database_cross_reference: CSP:2010-0179
database_cross_reference: DO:DOID:3852
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001473
database_cross_reference: ICD10CM:Q85.8
database_cross_reference: MDR:10034764
database_cross_reference: MEDCIN:30275
database_cross_reference: MSH:D010580
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:759.6
database_cross_reference: NCI:C3324
database_cross_reference: NCI_NCI-GLOSS:CDR0000377716
database_cross_reference: NCI_NCI-GLOSS:CDR0000377717
database_cross_reference: NDFRT:N0000002382
database_cross_reference: OMIM:175200
database_cross_reference: OMIM:602216
database_cross_reference: RCD:PK60.
database_cross_reference: SNM:D-5432
database_cross_reference: SNMI:D4-01035
database_cross_reference: SNOMEDCT_US:157029009
database_cross_reference: SNOMEDCT_US:54411001

adrenal cortex disease
type: Class
subclass of: adrenal gland disease
PMOID: PMO:00033230
Subclass_of: adrenal gland disease
Synonym: ADRENAL CORTEX DIS
Synonym: Adrenal Cortex Disease
Synonym: Adrenal Cortex Diseases
Synonym: Adrenal Cortex Diseases [Disease/Finding]
Synonym: Adrenal cortex--Diseases
Synonym: Cortex
Synonym: Cortex Disease, Adrenal
Synonym: Cortex Diseases, Adrenal
Synonym: Disease of adrenal cortex
Synonym: Disease of adrenal cortex (disorder)
Tree Number: T10.8.8.6.2
database_cross_reference: AOD:0000006001
database_cross_reference: CST:ENDO/ADR/COR
database_cross_reference: DO:DOID:3952
database_cross_reference: LCH_NW:sh85000995
database_cross_reference: MSH:D000303
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000322
database_cross_reference: SNM:D-2301
database_cross_reference: SNOMEDCT_US:129636003

oesophagostomiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the intestine in goats, pigs and humans by the nematode Oesophagostomum bifurcum. The symptoms are a low-grade fever, tenderness in the lower-right quadrant and painless cutaneous masses in the lower abdominal region. Rarely, Oesophagostomum spp will perforate the bowel wall, causing purulent peritonitis or migrate to the skin, producing cutaneous nodules.
PMOID: PMO:00029643
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Oesophagostomum
Tree Number: T10.7.4.1.21
database_cross_reference: DO:DOID:3983

tuberculosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.
PMOID: PMO:00029549
Subclass_of: primary bacterial infectious disease
Synonym: Tuberculoma
Synonym: Tuberculoma (disorder)
Synonym: Tuberculoma (finding)
Synonym: Tuberculoma [Disease/Finding]
Synonym: Tuberculoma, NOS
Synonym: Tuberculomas
Synonym: tuberculoma
Synonym: tuberculoma (diagnosis)
Synonym: tuberculomas
Tree Number: T10.7.3.1.30
database_cross_reference: CHV:0000012629
database_cross_reference: DO:DOID:399
database_cross_reference: MEDCIN:31061
database_cross_reference: MSH:D014375
database_cross_reference: NDFRT:N0000003029
database_cross_reference: SNM:M-44700
database_cross_reference: SNMI:DE-14808
database_cross_reference: SNOMEDCT_US:15202009

urinary system cancer
type: Class
subclass of: organ system cancer
PMOID: PMO:00026799
Subclass_of: organ system cancer
Synonym: Cancer of Urinary Tract
Synonym: Cancer of the Urinary Tract
Synonym: Cancer, Urinary Tract
Synonym: Cancer, Urologic
Synonym: Cancer, Urological
Synonym: Cancers, Urinary Tract
Synonym: Cancers, Urologic
Synonym: Cancers, Urological
Synonym: Mal neoplasm/urinary tract
Synonym: Malignant Urinary System Neoplasm
Tree Number: T10.2.1.2.12
database_cross_reference: AOD:0000004606
database_cross_reference: CHV:0000048461
database_cross_reference: ICD10:C64-C68.9
database_cross_reference: ICD10AM:C64-C68.9
database_cross_reference: ICD10CM:C64-C68
database_cross_reference: ICD10CM:C68.9
database_cross_reference: ICPC2P:U77007
database_cross_reference: MDR:10026706
database_cross_reference: MDR:10061272
database_cross_reference: MEDCIN:352275
database_cross_reference: MEDCIN:355762
database_cross_reference: MEDCIN:99707
database_cross_reference: MSH:D014571
database_cross_reference: MTHICD9:189.9
database_cross_reference: NCI:C9297
database_cross_reference: NCI_CTEP-SDC:10018192
database_cross_reference: RCD:Byu9.
database_cross_reference: RCD:X78it
database_cross_reference: RCDAE:X78it
database_cross_reference: RCDSY:Byu9.
database_cross_reference: SNMI:D7-F0103
database_cross_reference: SNOMEDCT_US:190131006
database_cross_reference: SNOMEDCT_US:363517008
database_cross_reference: SNOMEDCT_US:94125001

Disease
type: Class
subclass of: Thing
definition: A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
PMOID: PMO:00025114
Subclass_of: owl:Thing
Synonym: Clinical disease AND/OR syndrome
Synonym: Clinical disease AND/OR syndrome present
Synonym: Clinical disease or syndrome
Synonym: Clinical disease or syndrome present
Synonym: Clinical disease or syndrome present, NOS
Synonym: Clinical disease or syndrome, NOS
Synonym: DIS
Synonym: DISEASE
Synonym: Disease (disorder)
Synonym: Disease AND/OR syndrome present
Tree Number: T10
database_cross_reference: CCPSS:0007490
database_cross_reference: CHV:0000004014
database_cross_reference: CSP:0944-4756
database_cross_reference: DO:DOID:4
database_cross_reference: ICPC2P:A99001
database_cross_reference: LCH:U001423
database_cross_reference: LCH:U006403
database_cross_reference: LCH_NW:sh85038411
database_cross_reference: LNC:LP21006-9
database_cross_reference: MEDCIN:39448
database_cross_reference: MSH:D004194
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2991
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000407758
database_cross_reference: NCI_NCI-GLOSS:CDR0000651193
database_cross_reference: NCI_NICHD:C2991
database_cross_reference: NDFRT:N0000000981
database_cross_reference: PSY:14520
database_cross_reference: RCD:X0003
database_cross_reference: SNM:D-Y000
database_cross_reference: SNMI:DF-00000
database_cross_reference: SNOMEDCT_US:64572001

ureterocele
type: Class
subclass of: ureteral disease
definition: A ureteral disease that is characterized_as a congenital anomaly in which the distal end of the ureter swells as it enters the bladder.
PMOID: PMO:00032972
Subclass_of: ureteral disease
Synonym: URETEROCELE
Synonym: Ureterocele
Synonym: Ureterocele (disorder)
Synonym: Ureterocele [Disease/Finding]
Synonym: Ureteroceles
Synonym: ureterocele (diagnosis)
Synonym: ureteroceles
Tree Number: T10.8.7.5.1
database_cross_reference: CCPSS:0057230
database_cross_reference: CHV:0000012763
database_cross_reference: CHV:0000037073
database_cross_reference: DO:DOID:4022
database_cross_reference: HPO:HP:0000070
database_cross_reference: LCH:U004855
database_cross_reference: LCH_NW:sh85141371
database_cross_reference: MDR:10056433
database_cross_reference: MEDCIN:96703
database_cross_reference: MSH:D014518
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:593.89
database_cross_reference: NCI:C123159
database_cross_reference: NCI_NICHD:C123159
database_cross_reference: NDFRT:N0000003071
database_cross_reference: OMIM:191650
database_cross_reference: OMIM:MTHU004830
database_cross_reference: SNM:M-31650
database_cross_reference: SNMI:D4-73112
database_cross_reference: SNOMEDCT_US:12818004

gastritis
type: Class
subclass of: stomach disease
definition: A stomach disease that is an inflammation of the lining of the stomach.
PMOID: PMO:00033463
Subclass_of: stomach disease
Synonym: Already mapped above AAHA ID #: 832
Synonym: Catarrhal gastritis
Synonym: Erosive Gastritis
Synonym: Erosive gastropathy
Synonym: GASTRIC INFLAMMATION
Synonym: GASTRITIS
Synonym: Gastric catarrh
Synonym: Gastric inflammation
Synonym: Gastritides
Synonym: Gastritis
Tree Number: T10.8.11.3.6
database_cross_reference: AOD:0000005592
database_cross_reference: BI:BI00250
database_cross_reference: CCPSS:1018051
database_cross_reference: CHV:0000005376
database_cross_reference: COSTAR:322
database_cross_reference: CSP:1248-5717
database_cross_reference: CST:GASTRITIS
database_cross_reference: DO:DOID:4029
database_cross_reference: DXP:U001646
database_cross_reference: HPO:HP:0005263
database_cross_reference: ICD10:K29.7
database_cross_reference: ICD10AM:K29.7
database_cross_reference: ICD10CM:K29.7
database_cross_reference: ICPC2P:D87006
database_cross_reference: ICPC2P:D87012
database_cross_reference: LCH_NW:sh85128265
database_cross_reference: MDR:10017790
database_cross_reference: MDR:10017853
database_cross_reference: MDR:10017869
database_cross_reference: MDR:10021967
database_cross_reference: MDR:10042110
database_cross_reference: MDR:10078716
database_cross_reference: MEDCIN:30004
database_cross_reference: MEDLINEPLUS:420
database_cross_reference: MSH:D005756
database_cross_reference: NCI:C26780
database_cross_reference: NCI_CTCAE:E10733
database_cross_reference: NCI_FDA:1874
database_cross_reference: NCI_NCI-GLOSS:CDR0000330169
database_cross_reference: NCI_NICHD:C26780
database_cross_reference: NDFRT:N0000001314
database_cross_reference: RCD:J155.
database_cross_reference: RCD:X301N
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D5-32500
database_cross_reference: SNOMEDCT_US:155711008
database_cross_reference: SNOMEDCT_US:196743006
database_cross_reference: SNOMEDCT_US:235653009
database_cross_reference: SNOMEDCT_US:266503008
database_cross_reference: SNOMEDCT_US:4556007
database_cross_reference: SNOMEDCT_VET:4556007

mouth disease
type: Class
subclass of: gastrointestinal system disease
definition: A gastrointestinal system disease that is located_in the mouth.
PMOID: PMO:00033639
Subclass_of: gastrointestinal system disease
Synonym: Disease of mouth
Synonym: Disease of mouth (disorder)
Synonym: Disease of oral cavity
Synonym: Disease, Mouth
Synonym: Diseases, Mouth
Synonym: Disorder of mouth
Synonym: Disorder of mouth (diagnosis)
Synonym: Disorder of mouth (disorder)
Synonym: Disorder of oral cavity
Synonym: MOUTH DIS
Tree Number: T10.8.11.11
database_cross_reference: AOD:0000005470
database_cross_reference: AOD:0000023367
database_cross_reference: CHV:0000008285
database_cross_reference: DO:DOID:403
database_cross_reference: LCH_NW:sh85087993
database_cross_reference: MDR:10067621
database_cross_reference: MEDCIN:357175
database_cross_reference: MEDLINEPLUS:594
database_cross_reference: MSH:D009059
database_cross_reference: NCI:C27641
database_cross_reference: NCI:C3240
database_cross_reference: NDFRT:N0000002036
database_cross_reference: RCD:X20OM
database_cross_reference: SNM:D-6030
database_cross_reference: SNOMEDCT_US:118938008
database_cross_reference: SNOMEDCT_US:155630004
database_cross_reference: SNOMEDCT_US:266484002

eosinophilic gastroenteritis
type: Class
subclass of: gastroenteritis
definition: A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.
PMOID: PMO:00033521
Subclass_of: gastroenteritis
Synonym: EOSINOPHILIC GASTROENTERITIS
Synonym: Eosinophilic Gastroenteritis
Synonym: Eosinophilic gastroent
Synonym: Eosinophilic gastroenteritis
Synonym: Eosinophilic gastroenteritis (disorder)
Synonym: Eosinophilic gastroenteropathy
Synonym: Eosinophilic gastroenteropathy (disorder)
Synonym: Eosinophilic gastroenteropathy, NOS
Synonym: Gastroenteritis eosinophilic
Synonym: Infection by Anisakis larva
Tree Number: T10.8.11.5.1
database_cross_reference: CHV:0000056559
database_cross_reference: CSP:1248-5821
database_cross_reference: DO:DOID:4031
database_cross_reference: DO:DOID:7033
database_cross_reference: DXP:U000570
database_cross_reference: ICD9CM:558.41
database_cross_reference: MDR:10017902
database_cross_reference: MEDCIN:313225
database_cross_reference: MSH:C535952
database_cross_reference: NCI:C35330
database_cross_reference: SNMI:D5-00350
database_cross_reference: SNMI:DE-67900
database_cross_reference: SNOMEDCT_US:32183007
database_cross_reference: SNOMEDCT_US:359804008
database_cross_reference: SNOMEDCT_US:68270003

duodenogastric reflux
type: Class
subclass of: stomach disease
PMOID: PMO:00033454
Subclass_of: stomach disease
Synonym: DGR - Duodenogastric reflux
Synonym: Duodenal Reflux
Synonym: Duodenal Refluxs
Synonym: Duodeno Gastric Reflux
Synonym: Duodeno-Gastric Reflux
Synonym: Duodenogastric Reflux
Synonym: Duodenogastric Reflux [Disease/Finding]
Synonym: Duodenogastric reflux
Synonym: Duodenogastric reflux (finding)
Synonym: Reflux, Duodenal
Tree Number: T10.8.11.3.3
database_cross_reference: CHV:0000004181
database_cross_reference: DO:DOID:4071
database_cross_reference: MDR:10060865
database_cross_reference: MSH:D004383
database_cross_reference: NDFRT:N0000001010
database_cross_reference: RCD:X302S
database_cross_reference: SNMI:F-53010
database_cross_reference: SNOMEDCT_US:9733003

duodenal disease
type: Class
subclass of: intestinal disease
PMOID: PMO:00033623
Subclass_of: intestinal disease
Synonym: 5-34 DISEASES OF THE DUODENUM
Synonym: DISEASES OF THE DUODENUM
Synonym: DUODENAL DIS
Synonym: Disease of duodenum
Synonym: Disease of duodenum (disorder)
Synonym: Disease of duodenum, NOS
Synonym: Disease, Duodenal
Synonym: Diseases, Duodenal
Synonym: Disorder of duodenum
Synonym: Disorder of duodenum (disorder)
Tree Number: T10.8.11.8.25
database_cross_reference: CHV:0000004175
database_cross_reference: CSP:1248-4501
database_cross_reference: DO:DOID:4072
database_cross_reference: LCH_NW:sh85040000
database_cross_reference: MSH:D004378
database_cross_reference: NDFRT:N0000001005
database_cross_reference: RCD:X3029
database_cross_reference: SNM:D-6180
database_cross_reference: SNMI:D5-34000
database_cross_reference: SNOMEDCT_US:196598004
database_cross_reference: SNOMEDCT_US:52182008

heart valve disease
type: Class
subclass of: heart disease
definition: A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right).
PMOID: PMO:00031772
Subclass_of: heart disease
Synonym: CARDIAC VALVULAR DISEASE
Synonym: Cardiac valve disease
Synonym: Cardiac valve disorders
Synonym: Cardiac valvulopathy
Synonym: Disease, Heart Valve
Synonym: Disease, Valvular Heart
Synonym: Diseases, Heart Valve
Synonym: Diseases, Valvular Heart
Synonym: Disorder of Heart Valve
Synonym: Disorder of heart valve
Tree Number: T10.8.3.2.7
database_cross_reference: AOD:0000005382
database_cross_reference: AOD:0000023350
database_cross_reference: BI:BI00145
database_cross_reference: CCPSS:0032794
database_cross_reference: CCPSS:0035037
database_cross_reference: CHV:0000005894
database_cross_reference: COSTAR:778
database_cross_reference: CSP:1393-3757
database_cross_reference: CST:CARDIOVASC DIS
database_cross_reference: DO:DOID:4079
database_cross_reference: HPO:HP:0001654
database_cross_reference: LCH_NW:sh85059728
database_cross_reference: MDR:10019316
database_cross_reference: MDR:10046972
database_cross_reference: MDR:10046973
database_cross_reference: MDR:10057103
database_cross_reference: MDR:10061406
database_cross_reference: MEDCIN:35999
database_cross_reference: MEDLINEPLUS:279
database_cross_reference: MSH:D006349
database_cross_reference: MTH:778
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45525
database_cross_reference: NCI_NICHD:C45525
database_cross_reference: NDFRT:N0000001443
database_cross_reference: OMIM:MTHU007190
database_cross_reference: OMIM:MTHU039983
database_cross_reference: RCD:G54z5
database_cross_reference: RCD:XaB0g
database_cross_reference: SNM:D-7200
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D3-10800
database_cross_reference: SNOMEDCT_US:195013005
database_cross_reference: SNOMEDCT_US:368009

liver disease
type: Class
subclass of: hepatobiliary disease
PMOID: PMO:00033510
Subclass_of: hepatobiliary disease
Synonym: 5-80-81 DISEASES OF THE LIVER
Synonym: DISEASE HEPATOCELLULAR
Synonym: DISEASES OF THE LIVER
Synonym: DISORDER HEPATIC
Synonym: DISORDER LIVER
Synonym: Disease hepatocellular
Synonym: Disease of liver
Synonym: Disease of liver (disorder)
Synonym: Disease of liver [Ambiguous]
Synonym: Disease of liver, NOS
Tree Number: T10.8.11.4.2
database_cross_reference: AOD:0000005661
database_cross_reference: AOD:0000023384
database_cross_reference: CCPSS:0025497
database_cross_reference: CCPSS:1009350
database_cross_reference: CHV:0000007501
database_cross_reference: COSTAR:U000418
database_cross_reference: CSP:1754-6264
database_cross_reference: CST:DIG/LIV
database_cross_reference: CST:GIHEPATOCELL
database_cross_reference: CST:LIVER DAMAGE
database_cross_reference: DO:DOID:409
database_cross_reference: DXP:U002405
database_cross_reference: HPO:HP:0001392
database_cross_reference: ICD10:K70-K77.9
database_cross_reference: ICD10:K76.9
database_cross_reference: ICD10AM:K70-K77.9
database_cross_reference: ICD10AM:K76.9
database_cross_reference: ICD10CM:K70-K77
database_cross_reference: ICD10CM:K76.9
database_cross_reference: ICD9CM:573.9
database_cross_reference: ICPC2EENG:D97
database_cross_reference: ICPC2P:D97002
database_cross_reference: LCH_NW:sh85077755
database_cross_reference: LNC:LA17774-3
database_cross_reference: LNC:LA25810-5
database_cross_reference: MDR:10013107
database_cross_reference: MDR:10013228
database_cross_reference: MDR:10013234
database_cross_reference: MDR:10016313
database_cross_reference: MDR:10019650
database_cross_reference: MDR:10019651
database_cross_reference: MDR:10019652
database_cross_reference: MDR:10019653
database_cross_reference: MDR:10019706
database_cross_reference: MDR:10024670
database_cross_reference: MDR:10045808
database_cross_reference: MDR:10048518
database_cross_reference: MDR:10059616
database_cross_reference: MEDCIN:90247
database_cross_reference: MEDLINEPLUS:310
database_cross_reference: MSH:D008107
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3196
database_cross_reference: NCI:OMFAQ
database_cross_reference: NDFRT:N0000001866
database_cross_reference: OMIM:MTHU046632
database_cross_reference: PSY:22760
database_cross_reference: PSY:28630
database_cross_reference: RCD:J63z.
database_cross_reference: RCD:Jyu7.
database_cross_reference: RCD:X306R
database_cross_reference: RCDSY:Jyu7.
database_cross_reference: SNM:D-6331
database_cross_reference: SNMI:D5-80000
database_cross_reference: SNOMEDCT_US:155807008
database_cross_reference: SNOMEDCT_US:155817003
database_cross_reference: SNOMEDCT_US:155822003
database_cross_reference: SNOMEDCT_US:197375001
database_cross_reference: SNOMEDCT_US:197551000
database_cross_reference: SNOMEDCT_US:235856003
database_cross_reference: SNOMEDCT_US:266535008
database_cross_reference: SNOMEDCT_US:62857009
database_cross_reference: SNOMEDCT_VET:235856003

tick infestation
type: Class
subclass of: parasitic ectoparasitic infectious disease
definition: A parasitic ectoparasitic infectious disease that involves parasitic infestation of blood feeding ticks of the families Ixodidae and Argasidae on animals and humans. Ticks are vectors of a number diseases, including Lyme disease, Q fever, Colorado tick fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis and tick-borne meningoencephalitis, as well as anaplasmosis in cattle and canine jaundice.
PMOID: PMO:00029724
Subclass_of: parasitic ectoparasitic infectious disease
Tree Number: T10.7.4.4.4
database_cross_reference: DO:DOID:4109

parasitic ectoparasitic infectious disease
type: Class
subclass of: parasitic infectious disease
definition: A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host.
PMOID: PMO:00029714
Subclass_of: parasitic infectious disease
Synonym: Ectoparasitic Infestation
Synonym: Ectoparasitic Infestations
Synonym: Ectoparasitic Infestations [Disease/Finding]
Synonym: Ectoparasitic infestations
Synonym: Infestation, Ectoparasitic
Synonym: Infestations, Ectoparasitic
Synonym: ectoparasitism
Tree Number: T10.7.4.4
database_cross_reference: CSP:2214-2667
database_cross_reference: DO:DOID:4110
database_cross_reference: LCH:U001501
database_cross_reference: LCH_NW:sh85040891
database_cross_reference: MDR:10014143
database_cross_reference: MSH:D004478
database_cross_reference: NDFRT:N0000001051

nail disease
type: Class
subclass of: integumentary system disease
definition: An integumentary system disease that is located_in nail.
PMOID: PMO:00033758
Subclass_of: integumentary system disease
Synonym: 0-54 DISEASES OF THE NAILS
Synonym: DISEASES OF THE NAILS
Synonym: DISORDER NAIL
Synonym: Disease of nail
Synonym: Disease of nail (disorder)
Synonym: Disease of nail NOS
Synonym: Disease of nail, NOS
Synonym: Disease of nail, unspecified
Synonym: Disease, Nail
Synonym: Disease;nail(s)
Tree Number: T10.8.12.1
database_cross_reference: AOD:0000005242
database_cross_reference: AOD:0000023307
database_cross_reference: CHV:0000008465
database_cross_reference: COSTAR:506
database_cross_reference: COSTAR:U000460
database_cross_reference: CST:NAIL DIS
database_cross_reference: CST:SKIN/NAIL
database_cross_reference: DO:DOID:4123
database_cross_reference: HPO:HP:0001597
database_cross_reference: ICD10:L60
database_cross_reference: ICD10:L60.9
database_cross_reference: ICD10AM:L60
database_cross_reference: ICD10AM:L60.9
database_cross_reference: ICD10CM:L60
database_cross_reference: ICD10CM:L60.9
database_cross_reference: ICD9CM:703
database_cross_reference: ICD9CM:703.9
database_cross_reference: ICPC2P:S94001
database_cross_reference: ICPC2P:S99038
database_cross_reference: MDR:10013110
database_cross_reference: MDR:10013127
database_cross_reference: MDR:10013239
database_cross_reference: MDR:10028694
database_cross_reference: MDR:10028696
database_cross_reference: MDR:10045750
database_cross_reference: MEDCIN:98701
database_cross_reference: MEDLINEPLUS:532
database_cross_reference: MSH:D009260
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002103
database_cross_reference: RCD:M23..
database_cross_reference: RCD:M23z.
database_cross_reference: SNMI:D0-54000
database_cross_reference: SNOMEDCT_US:156401005
database_cross_reference: SNOMEDCT_US:17790008
database_cross_reference: SNOMEDCT_US:201127007
database_cross_reference: SNOMEDCT_US:267861009

biliary dyskinesia
type: Class
subclass of: gallbladder disease
definition: A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree.
PMOID: PMO:00033635
Subclass_of: gallbladder disease
Synonym: BILIARY DYSKINESIA
Synonym: Biliary Dyskinesia
Synonym: Biliary Dyskinesia [Disease/Finding]
Synonym: Biliary Dyskinesias
Synonym: Biliary dyskinesia
Synonym: Biliary dyskinesia (disorder)
Synonym: Biliary dyskinesia (disorder) [Ambiguous]
Synonym: Dyskinesia, Biliary
Synonym: Dyskinesias, Biliary
Synonym: biliary dyskinesia (diagnosis)
Tree Number: T10.8.11.10.3
database_cross_reference: CHV:0000001861
database_cross_reference: COSTAR:U000076
database_cross_reference: DO:DOID:4140
database_cross_reference: DXP:U000213
database_cross_reference: HPO:HP:0012396
database_cross_reference: MDR:10056529
database_cross_reference: MEDCIN:30039
database_cross_reference: MSH:D001657
database_cross_reference: MTHICD9:575.8
database_cross_reference: NDFRT:N0000000549
database_cross_reference: RCD:J65yB
database_cross_reference: SNM:F-63160
database_cross_reference: SNMI:D5-86160
database_cross_reference: SNOMEDCT_US:197432008
database_cross_reference: SNOMEDCT_US:43469007

syphilis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.
PMOID: PMO:00029534
Subclass_of: primary bacterial infectious disease
Synonym: CHANCRE
Synonym: Chancre
Synonym: Chancre [Disease/Finding]
Synonym: Chancre, syphilitic
Synonym: Chancres
Synonym: Primary syphilis - chancre
Synonym: SYPHILIS CHANCRE
Synonym: Syphilitic chancre
Synonym: Syphilitic chancre NOS
Synonym: chancre
Tree Number: T10.7.3.1.29
database_cross_reference: CCPSS:0060193
database_cross_reference: CHV:0000002717
database_cross_reference: DO:DOID:4166
database_cross_reference: DXP:U000644
database_cross_reference: ICD10CM:A51.0
database_cross_reference: MDR:10042901
database_cross_reference: MSH:D002601
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000740
database_cross_reference: RCD:XE0Rk
database_cross_reference: SNM:M-40020
database_cross_reference: SNMI:DE-14322
database_cross_reference: SNOMEDCT_US:266127002
database_cross_reference: SNOMEDCT_US:58433006

autoimmune hypersensitivity disease
type: Class
subclass of: hypersensitivity reaction disease
definition: An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.
PMOID: PMO:00032851
Subclass_of: hypersensitivity reaction disease
Synonym: Ankylosing spondylitis and other inflammatory spondylopathies
Synonym: autoimmune disease
Synonym: hypersensitivity reaction type II disease
Tree Number: T10.8.6.3.5
database_cross_reference: DO:DOID:417
database_cross_reference: ICD9CM:720
database_cross_reference: MDR:10002557

Rh isoimmunization
type: Class
subclass of: blood group incompatibility
PMOID: PMO:00033392
Subclass_of: blood group incompatibility
Synonym: Isoimmunization, Rh
Synonym: Isoimmunization, Rhesus
Synonym: Isoimmunizations, Rh
Synonym: Isoimmunizations, Rhesus
Synonym: RH ISOIMMUNIZATION
Synonym: RH iso-immunisation
Synonym: RH iso-immunization
Synonym: RH;iso-immunisation
Synonym: RH;iso-immunization
Synonym: RI - Rhesus isoimmunisation
Tree Number: T10.8.10.5.1
database_cross_reference: CCPSS:0041879
database_cross_reference: CHV:0000010832
database_cross_reference: DO:DOID:4175
database_cross_reference: ICPC2P:W84014
database_cross_reference: MDR:10039016
database_cross_reference: MDR:10039038
database_cross_reference: MDR:10056231
database_cross_reference: MDR:10056232
database_cross_reference: MEDCIN:35346
database_cross_reference: MSH:D012203
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:656.1
database_cross_reference: MTHICD9:773.0
database_cross_reference: NCI:C113150
database_cross_reference: NCI_NICHD:C113150
database_cross_reference: NDFRT:N0000002625
database_cross_reference: RCD:L2610
database_cross_reference: RCD:L261z
database_cross_reference: RCD:XE0wn
database_cross_reference: RCDAE:L2610
database_cross_reference: RCDAE:L261z
database_cross_reference: RCDAE:XE0wn
database_cross_reference: SNMI:D8-21420
database_cross_reference: SNOMEDCT_US:156182009
database_cross_reference: SNOMEDCT_US:199580004
database_cross_reference: SNOMEDCT_US:199581000
database_cross_reference: SNOMEDCT_US:199584008
database_cross_reference: SNOMEDCT_US:44795003

blood group incompatibility
type: Class
subclass of: hematopoietic system disease
PMOID: PMO:00033391
Subclass_of: hematopoietic system disease
Synonym: Blood Group Incompatibilities
Synonym: Blood Group Incompatibility
Synonym: Group Incompatibilities, Blood
Synonym: Group Incompatibility, Blood
Synonym: Incompatibilities, Blood Group
Synonym: Incompatibility, Blood Group
Tree Number: T10.8.10.5
database_cross_reference: AOD:0000005917
database_cross_reference: CHV:0000002002
database_cross_reference: CSP:0440-3703
database_cross_reference: DO:DOID:4176
database_cross_reference: MSH:D001787

pseudohypoparathyroidism
type: Class
subclass of: metal metabolism disorder
PMOID: PMO:00029015
Subclass_of: metal metabolism disorder
Synonym: AHO - Albright hered osteodyst
Synonym: AHO - Albright hereditary osteodystrophy
Synonym: Albright hereditary osteodystr
Synonym: Albright hereditary osteodystrophy
Synonym: Albright hereditary osteodystrophy (AHO)
Synonym: Albright hereditary osteodystrophy, NOS
Synonym: Albright syndrome 1
Synonym: Constitutional chronic hypocalcaemia
Synonym: Constitutional chronic hypocalcemia
Synonym: Familial pseudohypoparathyroidism
Tree Number: T10.6.2.4.4
database_cross_reference: CHV:0000010290
database_cross_reference: CSP:1849-7959
database_cross_reference: DO:DOID:4184
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001607
database_cross_reference: HPO:HP:0000852
database_cross_reference: ICD10:E20.1
database_cross_reference: ICD10AM:E20.1
database_cross_reference: ICD10CM:E20.1
database_cross_reference: ICPC2P:T80005
database_cross_reference: JABL:18
database_cross_reference: LCH:U003891
database_cross_reference: LCH_NW:sh85108274
database_cross_reference: MDR:10037126
database_cross_reference: MEDCIN:30516
database_cross_reference: MSH:D011547
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:275.49
database_cross_reference: NCI:C99027
database_cross_reference: NCI_NICHD:C99027
database_cross_reference: NDFRT:N0000002518
database_cross_reference: OMIM:MTHU005113
database_cross_reference: RCD:XE11f
database_cross_reference: SNM:D-2272
database_cross_reference: SNMI:DB-90850
database_cross_reference: SNOMEDCT_US:154697005
database_cross_reference: SNOMEDCT_US:190867002
database_cross_reference: SNOMEDCT_US:267479004
database_cross_reference: SNOMEDCT_US:58976002

glucose metabolism disease
type: Class
subclass of: carbohydrate metabolism disease
PMOID: PMO:00028854
Subclass_of: carbohydrate metabolism disease
Synonym: Disorder of Glucose Metabolism
Synonym: Disorder of glucose metabolism
Synonym: Disorder of glucose metabolism (disorder)
Synonym: Disorder, Glucose Metabolic
Synonym: Disorder, Glucose Metabolism
Synonym: Disorders, Glucose Metabolic
Synonym: Disorders, Glucose Metabolism
Synonym: GLUCOSE METAB DIS
Synonym: Glucose Metabolic Disorder
Synonym: Glucose Metabolic Disorders
Tree Number: T10.6.1.3.1
database_cross_reference: CHV:0000056277
database_cross_reference: DO:DOID:4194
database_cross_reference: MEDCIN:90718
database_cross_reference: MSH:D044882
database_cross_reference: NCI:C53655
database_cross_reference: NDFRT:N0000011123
database_cross_reference: SNOMEDCT_US:126877002

hypertrichosis
type: Class
subclass of: hair disease
definition: A hair disease characterized by hair growth that is abnormal in quantity or location.
PMOID: PMO:00034006
Subclass_of: hair disease
Synonym: Excessive growth of hair
Synonym: Excessive hair growth
Synonym: Excessive hair growth (disorder)
Synonym: Excessive hair growth (finding)
Synonym: Excessive hairiness
Synonym: HYPERTRICHIASIS
Synonym: HYPERTRICHOSIS
Synonym: Hairiness
Synonym: Hirsutism - hypertrichosis
Synonym: Hypertrichiasis
Tree Number: T10.8.12.3.2
database_cross_reference: CCPSS:1006399
database_cross_reference: CHV:0000006152
database_cross_reference: CHV:0000006454
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:HIRSUTISM
database_cross_reference: DO:DOID:420
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0000998
database_cross_reference: ICD10:L68
database_cross_reference: ICD10:L68.3
database_cross_reference: ICD10:L68.9
database_cross_reference: ICD10AM:L68
database_cross_reference: ICD10AM:L68.3
database_cross_reference: ICD10AM:L68.9
database_cross_reference: ICD10CM:L68
database_cross_reference: ICD10CM:L68.3
database_cross_reference: ICD10CM:L68.9
database_cross_reference: LCH:U002320
database_cross_reference: LCH_NW:sh85063732
database_cross_reference: MDR:10020863
database_cross_reference: MDR:10020864
database_cross_reference: MEDCIN:311619
database_cross_reference: MEDCIN:319400
database_cross_reference: MSH:D006983
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:704.1
database_cross_reference: NCI:C79597
database_cross_reference: NCI_CTCAE:E13649
database_cross_reference: NCI_NICHD:C79597
database_cross_reference: NDFRT:N0000001624
database_cross_reference: OMIM:MTHU036754
database_cross_reference: OMIM:MTHU051811
database_cross_reference: RCD:M241.
database_cross_reference: RCD:M241z
database_cross_reference: SNM:M-56430
database_cross_reference: SNM:M-56440
database_cross_reference: SNMI:D0-53220
database_cross_reference: SNOMEDCT_US:156409007
database_cross_reference: SNOMEDCT_US:201164001
database_cross_reference: SNOMEDCT_US:201165000
database_cross_reference: SNOMEDCT_US:271607001
database_cross_reference: SNOMEDCT_US:29966009
database_cross_reference: SNOMEDCT_US:40090008
database_cross_reference: SNOMEDCT_VET:29966009

hair disease
type: Class
subclass of: integumentary system disease
definition: An integumentary system disease that is located_in hair.
PMOID: PMO:00033985
Subclass_of: integumentary system disease
Synonym: DISEASE OF HAIR
Synonym: DISORDER HAIR
Synonym: Disorder hair
Synonym: Disorder of hair
Synonym: Disorder of hair (disorder)
Synonym: HAIR DIS
Synonym: HAIR DISEASE
Synonym: HAIR DISORDER
Synonym: Hair Disease
Synonym: Hair Diseases
Tree Number: T10.8.12.3
database_cross_reference: CHV:0000005766
database_cross_reference: COSTAR:243
database_cross_reference: CST:HAIR DIS
database_cross_reference: CST:SKIN/HAIR
database_cross_reference: DO:DOID:421
database_cross_reference: LCH_NW:sh85058308
database_cross_reference: MDR:10013226
database_cross_reference: MDR:10019037
database_cross_reference: MDR:10019038
database_cross_reference: MEDLINEPLUS:531
database_cross_reference: MSH:D006201
database_cross_reference: MTH:243
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34656
database_cross_reference: NDFRT:N0000001399
database_cross_reference: RCD:Xa151
database_cross_reference: SNOMEDCT_US:156407009
database_cross_reference: SNOMEDCT_US:267862002
database_cross_reference: SNOMEDCT_US:279425004

gynatresia
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is characterized by the occlusion of some part of the female genital tract, especially occlusion of the vagina.
PMOID: PMO:00029828
Subclass_of: female reproductive system disease
Synonym: Gynatresia
Synonym: Gynatresia [Disease/Finding]
Synonym: Gynatresias
Tree Number: T10.8.1.4.11
database_cross_reference: DO:DOID:429
database_cross_reference: MSH:D006175
database_cross_reference: NCI:C84743
database_cross_reference: NDFRT:N0000001395

Ebola hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has material basis in Zaire ebolavirus, has material basis in Sudan ebolavirus, has material basis in Cote d'Ivoire ebolavirus, or has material basis in Bundibugyo ebolavirus, which are transmitted by contact with the body fluids of an infected animal or person, transmitted by contaminated fomites, or transmitted by infected medical equipment. The infection has symptom fever, has symptom headache, has symptom joint pain, has symptom muscle aches, has symptom sore throat, has symptom weakness, has symptom diarrhea, has symptom vomiting, has symptom stomach pain, has symptom rash, has symptom red eyes, has symptom hiccups, and has symptom internal and external bleeding.
PMOID: PMO:00029441
Subclass_of: viral infectious disease
Synonym: EBOLA VIRUS DIS
Synonym: EVD - Ebola virus disease
Synonym: Ebola
Synonym: Ebola Hemorrhagic Fever
Synonym: Ebola Infection
Synonym: Ebola Virus Disease
Synonym: Ebola Virus Infection
Synonym: Ebola disease
Synonym: Ebola haemorrhagic fever
Synonym: Ebola virus disease
Tree Number: T10.7.2.72
database_cross_reference: CHV:0000027699
database_cross_reference: DO:DOID:4325
database_cross_reference: ICD10:A98.4
database_cross_reference: ICD10AM:A98.4
database_cross_reference: ICD10CM:A98.4
database_cross_reference: LCH_NW:sh85040654
database_cross_reference: LNC:LA10453-1
database_cross_reference: MDR:10014071
database_cross_reference: MDR:10014072
database_cross_reference: MDR:10014074
database_cross_reference: MDR:10055245
database_cross_reference: MEDCIN:38325
database_cross_reference: MEDLINEPLUS:6202
database_cross_reference: MSH:D019142
database_cross_reference: NCI:C36171
database_cross_reference: NCI_NICHD:C36171
database_cross_reference: NDFRT:N0000003898
database_cross_reference: RCD:X70LA
database_cross_reference: SNMI:DE-37050
database_cross_reference: SNOMEDCT_US:123323003
database_cross_reference: SNOMEDCT_US:186746000
database_cross_reference: SNOMEDCT_US:37109004

Marburg hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.
PMOID: PMO:00029391
Subclass_of: viral infectious disease
Synonym: Marburg disease
Synonym: Marburg virus disease
Tree Number: T10.7.2.35
database_cross_reference: DO:DOID:4327

burning mouth syndrome
type: Class
subclass of: mouth disease
PMOID: PMO:00033722
Subclass_of: mouth disease
Synonym: BMS - Burning mouth syndrome
Synonym: Burning Mouth Syndrome
Synonym: Burning Mouth Syndrome [Disease/Finding]
Synonym: Burning Mouth Syndromes
Synonym: Burning mouth syndrome
Synonym: Burning mouth syndrome (disorder)
Synonym: Mouth Syndrome, Burning
Synonym: Mouth Syndromes, Burning
Synonym: Oral Dysesthesia
Synonym: Oral dysaesthesia
Tree Number: T10.8.11.11.7
database_cross_reference: CHV:0000002234
database_cross_reference: CHV:0000052482
database_cross_reference: DO:DOID:4331
database_cross_reference: MDR:10050820
database_cross_reference: MDR:10054520
database_cross_reference: MDR:10068065
database_cross_reference: MEDCIN:283562
database_cross_reference: MSH:D002054
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C62545
database_cross_reference: NCI_CTCAE:E10894
database_cross_reference: NCI_NICHD:C62545
database_cross_reference: NDFRT:N0000000634
database_cross_reference: RCD:X20QN
database_cross_reference: SNOMEDCT_US:111349000
database_cross_reference: SNOMEDCT_US:399165002

parovarian cyst
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is characterized by epithelium-lined fluid-filled cysts in the adnexa adjacent to the fallopian tube and ovary.
PMOID: PMO:00029829
Subclass_of: female reproductive system disease
Synonym: Cyst, Parovarian
Synonym: Cyst, fimbrial
Synonym: Cyst, parovarian
Synonym: Cysts, Parovarian
Synonym: Embryonic fimbrial cyst
Synonym: Embryonic fimbrial cyst (disorder)
Synonym: Fimbrial cyst
Synonym: PAROVARIAN CYST
Synonym: Parovarian Cyst
Synonym: Parovarian Cyst [Disease/Finding]
Tree Number: T10.8.1.4.12
database_cross_reference: CHV:0000009327
database_cross_reference: DO:DOID:4333
database_cross_reference: DXP:U001426
database_cross_reference: ICD10CM:Q50.4
database_cross_reference: ICD10CM:Q50.5
database_cross_reference: MDR:10052456
database_cross_reference: MSH:D010310
database_cross_reference: MTHICD9:752.11
database_cross_reference: NDFRT:N0000002334
database_cross_reference: RCD:PC111
database_cross_reference: RCD:PC113
database_cross_reference: SNM:M-33400
database_cross_reference: SNMI:D4-81524
database_cross_reference: SNOMEDCT_US:204831002
database_cross_reference: SNOMEDCT_US:64233004

lymphocele
type: Class
subclass of: lymphatic system disease
PMOID: PMO:00032917
Subclass_of: lymphatic system disease
Synonym: Cyst, Lymphatic
Synonym: Cysts, Lymphatic
Synonym: Lymph cyst
Synonym: Lymph cyst (disorder)
Synonym: Lymphatic Cyst
Synonym: Lymphatic Cysts
Synonym: Lymphatic cyst
Synonym: Lymphocele
Synonym: Lymphocele (diagnosis)
Synonym: Lymphocele (disorder)
Tree Number: T10.8.6.4.2
database_cross_reference: CHV:0000007606
database_cross_reference: CHV:0000029630
database_cross_reference: CHV:0000039002
database_cross_reference: DO:DOID:4347
database_cross_reference: MDR:10048642
database_cross_reference: MDR:10052356
database_cross_reference: MEDCIN:360605
database_cross_reference: MSH:D008210
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78442
database_cross_reference: NCI_CTCAE:E13806
database_cross_reference: NDFRT:N0000001901
database_cross_reference: RCD:X207D
database_cross_reference: RCD:X207E
database_cross_reference: SNM:M-33570
database_cross_reference: SNMI:M-33570
database_cross_reference: SNOMEDCT_US:12167004
database_cross_reference: SNOMEDCT_US:234109007
database_cross_reference: SNOMEDCT_US:234110002

stomach diverticulosis
type: Class
subclass of: stomach disease
PMOID: PMO:00033482
Subclass_of: stomach disease
Synonym: Diverticulosis, Gastric
Synonym: Diverticulosis, Stomach
Synonym: Diverticulosis, Stomach [Disease/Finding]
Synonym: Gastric Diverticulosis
Synonym: Stomach Diverticulosis
Tree Number: T10.8.11.3.11
database_cross_reference: DO:DOID:4370
database_cross_reference: MSH:D045724
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000010935

folliculitis
type: Class
subclass of: hair disease
PMOID: PMO:00033857
Subclass_of: hair disease
Synonym: FOLLICULITIS
Synonym: Follicle inflamed
Synonym: Folliculitides
Synonym: Folliculitis
Synonym: Folliculitis (disorder)
Synonym: Folliculitis NOS
Synonym: Folliculitis NOS (disorder)
Synonym: Folliculitis [Disease/Finding]
Synonym: Hair follicle inflamed
Synonym: Hair follicle inflammation
Tree Number: T10.8.12.3.4
database_cross_reference: BI:BI00586
database_cross_reference: CCPSS:0050840
database_cross_reference: CHV:0000005159
database_cross_reference: COSTAR:309
database_cross_reference: CSP:2716-6472
database_cross_reference: CST:ACNE
database_cross_reference: DO:DOID:4409
database_cross_reference: HPO:HP:0025084
database_cross_reference: ICPC2P:S10008
database_cross_reference: ICPC2P:S11007
database_cross_reference: MDR:10016936
database_cross_reference: MEDCIN:34391
database_cross_reference: MEDLINEPLUS:531
database_cross_reference: MSH:D005499
database_cross_reference: MTHICD9:704.8
database_cross_reference: NCI:C94408
database_cross_reference: NCI_NCI-GLOSS:CDR0000641111
database_cross_reference: NCI_NICHD:C94408
database_cross_reference: NDFRT:N0000001269
database_cross_reference: OMIM:MTHU024866
database_cross_reference: RCD:M244z
database_cross_reference: RCD:XE1Cq
database_cross_reference: SNM:M-47400
database_cross_reference: SNMI:D0-00564
database_cross_reference: SNOMEDCT_US:13600006
database_cross_reference: SNOMEDCT_US:156411003
database_cross_reference: SNOMEDCT_US:201177005
database_cross_reference: SNOMEDCT_US:201183008
database_cross_reference: SNOMEDCT_US:267863007
database_cross_reference: SNOMEDCT_US:721130001
database_cross_reference: SNOMEDCT_VET:13600006

hepatitis E
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.
PMOID: PMO:00029378
Subclass_of: viral infectious disease
Synonym: ET NANBH
Synonym: ET-NANBH
Synonym: Enterically Transmitted Non A, Non B Hepatitis
Synonym: Enterically transmitted non-A non-B hepatitis
Synonym: Enterically-Transmitted Non-A, Non-B Hepatitis
Synonym: Epidemic Non A, Non B Hepatitis
Synonym: Epidemic Non-A, Non-B Hepatitis
Synonym: Epidemic non-A non-B hepatitis
Synonym: Faecal-oral non-A non-B hepatitis
Synonym: Fecal-oral non-A non-B hepatitis
Tree Number: T10.7.2.28
database_cross_reference: AOD:0000004807
database_cross_reference: CHV:0000015549
database_cross_reference: CSP:4000-0219
database_cross_reference: DO:DOID:4411
database_cross_reference: LCH_NW:sh92000217
database_cross_reference: MDR:10014865
database_cross_reference: MDR:10014977
database_cross_reference: MDR:10016300
database_cross_reference: MDR:10019768
database_cross_reference: MDR:10056116
database_cross_reference: MSH:D016751
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003469
database_cross_reference: SNOMEDCT_US:7111000119109

renal tubular transport disease
type: Class
subclass of: kidney disease
PMOID: PMO:00033058
Subclass_of: kidney disease
Synonym: KIDNEY TUB TRANSP INBORN ERR
Synonym: KIDNEY TUBULAR TRANSPORT INBORN ERR
Synonym: Kidney Tubular Transport, Inborn Error
Synonym: Kidney Tubular Transport, Inborn Errors
Synonym: RENAL TUB TRANSP ERR
Synonym: RENAL TUB TRANSP INBORN ERR
Synonym: RENAL TUBULAR TRANSPORT INBORN ERR
Synonym: Renal Tubular Transport Errors
Synonym: Renal Tubular Transport, Inborn Error
Synonym: Renal Tubular Transport, Inborn Errors
Tree Number: T10.8.7.9.20
database_cross_reference: CSP:1849-8301
database_cross_reference: DO:DOID:447
database_cross_reference: MSH:D015499
database_cross_reference: NDFRT:N0000003278

persian gulf syndrome
type: Class
subclass of: syndrome
definition: A syndrome affecting returning military veterans and civilian workers of the Gulf War.
PMOID: PMO:00025128
Subclass_of: syndrome
Synonym: Gulf War Syndrome
Synonym: Gulf war syndrome
Synonym: Gulf war syndrome (disorder)
Synonym: Gulf war syndrome, NOS
Synonym: Persian Gulf Syndrome
Synonym: Persian Gulf Syndrome [Disease/Finding]
Synonym: Persian Gulf syndrome
Synonym: Persian Gulf war syndrome
Synonym: Persian Gulf war syndrome (diagnosis)
Synonym: Syndrome, Gulf War
Tree Number: T10.1.13
database_cross_reference: CHV:0000027640
database_cross_reference: DO:DOID:4491
database_cross_reference: LCH_NW:sh98000483
database_cross_reference: MDR:10056557
database_cross_reference: MEDCIN:272068
database_cross_reference: MEDLINEPLUS:453
database_cross_reference: MSH:D018923
database_cross_reference: NDFRT:N0000003881
database_cross_reference: SNMI:DD-84D10
database_cross_reference: SNOMEDCT_US:95877004

avian influenza
type: Class
subclass of: influenza
definition: An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has material basis in Influenza A virus, which is transmitted by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has symptom fever, has symptom cough, has symptom sore throat, has symptom muscle aches, has symptom nausea, has symptom diarrhea, has symptom vomiting, has symptom neurologic changes, has symptom pneumonia, and has symptom acute respiratory distress.
PMOID: PMO:00029415
Subclass_of: influenza
Synonym: Influenza A/H5N1
Synonym: avian flu
Synonym: bird flu
Synonym: influenza A subtype H5N1 infection
Synonym: influenza A subtype H5N1 infection (diagnosis)
Synonym: influenza A(H5N1)
Tree Number: T10.7.2.50.2
database_cross_reference: DO:DOID:4492
database_cross_reference: ICD10CM:J09.X
database_cross_reference: MEDCIN:276271
database_cross_reference: MTHICD9:488.0

hypokalemia
type: Class
subclass of: mineral metabolism disease
PMOID: PMO:00028923
Subclass_of: mineral metabolism disease
Synonym: Deficiencies, Potassium
Synonym: Deficiency, Potassium
Synonym: Hypokalemia
Synonym: K deficiency
Synonym: K+ decreased
Synonym: Low blood potassium levels
Synonym: POTASSIUM DEFIC
Synonym: POTASSIUM DEFICIENCY
Synonym: Potassium Deficiencies
Synonym: Potassium Deficiency
Tree Number: T10.6.1.5.1
database_cross_reference: AOD:0000023492
database_cross_reference: CHV:0000010007
database_cross_reference: COSTAR:604
database_cross_reference: CSP:1851-4491
database_cross_reference: CST:HYPOKALEM
database_cross_reference: DO:DOID:13582
database_cross_reference: HPO:HP:0002900
database_cross_reference: MDR:10023273
database_cross_reference: MDR:10036445
database_cross_reference: MSH:D011191
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:276.8
database_cross_reference: NDFRT:N0000002470
database_cross_reference: RCD:X40Xv
database_cross_reference: SNMI:D6-21100
database_cross_reference: SNOMEDCT_US:154762003
database_cross_reference: SNOMEDCT_US:267508008
database_cross_reference: SNOMEDCT_US:43339004

orofaciodigital syndrome
type: Class
subclass of: genetic disease
definition: A genetic disease that is characterized by malformations of the face, oral cavity, and digits.
PMOID: PMO:00028740
Subclass_of: genetic disease
Synonym: Dysplasia Linguofacialis
Synonym: Oral-Facial-Digital Syndrome
Synonym: Oro-Facio-Digital Syndrome
Synonym: Orodigitofacial Dysostosis
Synonym: Orodigitofacial Syndrome
Synonym: Orofaciodigital Syndrome
Synonym: Orofaciodigital Syndromes
Synonym: Orofaciodigital Syndromes [Disease/Finding]
Synonym: Syndrome, Orofaciodigital
Synonym: Syndromes, Orofaciodigital
Tree Number: T10.5.5
database_cross_reference: CHV:0000009037
database_cross_reference: DO:DOID:4501
database_cross_reference: MSH:D009958
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002237

Hallermann-Streiff syndrome
type: Class
subclass of: syndrome
definition: A syndrome that affects growth, cranial development, hair growth and dental development.
PMOID: PMO:00025137
Subclass_of: syndrome
Synonym: Dyscephalic Syndrome, Francois
Synonym: Dyscephalic Syndromes, Francois
Synonym: FRANCOIS DYSCEPHALIC SYNDROME
Synonym: Francois Dyscephalic Syndrome
Synonym: Francois Dyscephalic Syndromes
Synonym: Francois dyscephalia
Synonym: Francois dyscephalic syndrome
Synonym: HALLERMANN-STREIFF SYNDROME
Synonym: HSS
Synonym: Hallerman - Streif syndrome
Tree Number: T10.1.22
database_cross_reference: CHV:0000005774
database_cross_reference: DO:DOID:4534
database_cross_reference: JABL:334
database_cross_reference: MEDCIN:38227
database_cross_reference: MSH:D006210
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84746
database_cross_reference: NDFRT:N0000001401
database_cross_reference: OMIM:234100
database_cross_reference: RCD:Xa0Wn
database_cross_reference: SNM:D-5015
database_cross_reference: SNMI:D4-00209
database_cross_reference: SNOMEDCT_US:205417000
database_cross_reference: SNOMEDCT_US:7903009

hypotrichosis
type: Class
subclass of: hair disease
definition: A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles.
PMOID: PMO:00033986
Subclass_of: hair disease
Synonym: Congenital hypotrichia
Synonym: Congenital hypotrichia (disorder)
Synonym: Congenital hypotrichosis
Synonym: HYPOTRICHOSIS
Synonym: Hair scanty
Synonym: Hair thin
Synonym: Hair thinning
Synonym: Hypotrichoses
Synonym: Hypotrichosis
Synonym: Hypotrichosis (disorder)
Tree Number: T10.8.12.3.1
database_cross_reference: CHV:0000006503
database_cross_reference: CST:ALOPECIA
database_cross_reference: DO:DOID:4535
database_cross_reference: HPO:HP:0001006
database_cross_reference: MDR:10021126
database_cross_reference: MEDCIN:204577
database_cross_reference: MSH:D007039
database_cross_reference: MTH:U001999
database_cross_reference: MTHICD9:704.09
database_cross_reference: NCI:C34720
database_cross_reference: NDFRT:N0000001655
database_cross_reference: OMIM:MTHU002744
database_cross_reference: OMIM:MTHU005949
database_cross_reference: OMIM:MTHU007753
database_cross_reference: RCD:X509L
database_cross_reference: RCD:X78Dg
database_cross_reference: SNM:M-21300
database_cross_reference: SNMI:D0-53200
database_cross_reference: SNMI:D4-41002
database_cross_reference: SNOMEDCT_US:53602002
database_cross_reference: SNOMEDCT_US:56558005
database_cross_reference: SNOMEDCT_VET:53602002

retrograde amnesia
type: Class
subclass of: amnestic disorder
definition: An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection.
PMOID: PMO:00028215
Subclass_of: amnestic disorder
Synonym: AMNESIA RETROGRADE
Synonym: Amnesia (retrograde)
Synonym: Amnesia, Retrograde
Synonym: Amnesia, Retrograde [Disease/Finding]
Synonym: Amnesias, Retrograde
Synonym: RA - Retrograde amnesia
Synonym: Retrograde Amnesia
Synonym: Retrograde Amnesias
Synonym: Retrograde amnesia
Synonym: Retrograde amnesia (finding)
Tree Number: T10.3.12.4.1
database_cross_reference: AOD:0000006367
database_cross_reference: CCPSS:0041898
database_cross_reference: CHV:0000001034
database_cross_reference: DO:DOID:4543
database_cross_reference: ICD10:R41.2
database_cross_reference: ICD10AM:R41.2
database_cross_reference: ICD10CM:R41.2
database_cross_reference: MDR:10038965
database_cross_reference: MSH:D000648
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.93
database_cross_reference: NCI:C34372
database_cross_reference: NDFRT:N0000000372
database_cross_reference: PSY:58073
database_cross_reference: RCD:R00z0
database_cross_reference: RCD:XM06s
database_cross_reference: RCDSY:R00z0
database_cross_reference: SNMI:F-96024
database_cross_reference: SNOMEDCT_US:158178004
database_cross_reference: SNOMEDCT_US:206784007
database_cross_reference: SNOMEDCT_US:51921000

oral leukoedema
type: Class
subclass of: mouth disease
PMOID: PMO:00033640
Subclass_of: mouth disease
Synonym: Leukedema of mouth
Synonym: Leukedema of mouth (disorder)
Synonym: Leukoedema of mouth
Synonym: Leukoedema of mouth (disorder)
Synonym: Leukoedema, Oral
Synonym: Leukoedema, Oral [Disease/Finding]
Synonym: Leukoedemas, Oral
Synonym: Oral Leukoedema
Synonym: Oral Leukoedemas
Synonym: Oral leukoedema
Tree Number: T10.8.11.11.1
database_cross_reference: DO:DOID:4557
database_cross_reference: MDR:10057365
database_cross_reference: MEDCIN:219309
database_cross_reference: MSH:D007967
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001835
database_cross_reference: RCD:J0872
database_cross_reference: SNMI:D5-21514
database_cross_reference: SNOMEDCT_US:67795000

ascariasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation.
PMOID: PMO:00029645
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Ascariasis - roundworm
Tree Number: T10.7.4.1.23
database_cross_reference: DO:DOID:456

epidermolytic hyperkeratosis
type: Class
subclass of: skin disease
PMOID: PMO:00033891
Subclass_of: skin disease
Synonym: BCIE
Synonym: BIE
Synonym: BIE - Bull ichthy erythroderma
Synonym: BIE - Bullous ichthyosiform erythroderma
Synonym: BULLOUS CONGEN ICHTHYOSIFORM ERYTHRODERMA
Synonym: BULLOUS CONGENITAL ICHTHYOSIFORM ERYTHRODERMA
Synonym: BULLOUS ERYTHRODERMA ICHTHYOSIFORMIS CONGENITA OF BROCQ
Synonym: BULLOUS ICHTHYOSIFORM ERYTHRODERMA
Synonym: Bull ichthyosform erythroderma
Synonym: Bullous Congenital Ichthyosiform Erythroderma
Tree Number: T10.8.12.2.24
database_cross_reference: CHV:0000015117
database_cross_reference: CHV:0000030837
database_cross_reference: DO:DOID:4603
database_cross_reference: HPO:HP:0007475
database_cross_reference: ICD10:Q80.3
database_cross_reference: ICD10AM:Q80.3
database_cross_reference: ICD10CM:Q80.3
database_cross_reference: MDR:10006562
database_cross_reference: MDR:10014990
database_cross_reference: MDR:10078292
database_cross_reference: MEDCIN:331130
database_cross_reference: MSH:D017488
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C62569
database_cross_reference: NDFRT:N0000003584
database_cross_reference: OMIM:113800
database_cross_reference: OMIM:139350
database_cross_reference: OMIM:148080
database_cross_reference: OMIM:MTHU049753
database_cross_reference: RCD:X78CI
database_cross_reference: SNM:D-3678
database_cross_reference: SNMI:D4-40111
database_cross_reference: SNOMEDCT_US:20512000
database_cross_reference: SNOMEDCT_US:239071005
database_cross_reference: SNOMEDCT_US:254167000

holoprosencephaly
type: Class
subclass of: congenital nervous system abnormality
definition: A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies.
PMOID: PMO:00028243
Subclass_of: congenital nervous system abnormality
Synonym: Familial alobar holoprosencephaly
Synonym: Familial alobar holoprosencephaly (disorder)
Synonym: Familial alobar holoprosencephaly -RETIRED-
Synonym: HPE - Holoprosencephaly
Synonym: HPE, FAMILIAL
Synonym: HPE1
Synonym: HPEC
Synonym: Holoprosencephalies
Synonym: Holoprosencephaly
Synonym: Holoprosencephaly (HPE)
Tree Number: T10.4.1.5
database_cross_reference: CHV:0000015186
database_cross_reference: CSP:0723-2277
database_cross_reference: DO:DOID:0110881
database_cross_reference: DO:DOID:4621
database_cross_reference: HPO:HP:0001360
database_cross_reference: ICD10:Q04.2
database_cross_reference: ICD10AM:Q04.2
database_cross_reference: ICD10CM:Q04.2
database_cross_reference: LCH_NW:sh89007234
database_cross_reference: MDR:10056304
database_cross_reference: MEDCIN:218980
database_cross_reference: MSH:D016142
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:742.2
database_cross_reference: NCI:C74988
database_cross_reference: NCI_NICHD:C74988
database_cross_reference: NDFRT:N0000003376
database_cross_reference: OMIM:236100
database_cross_reference: OMIM:MTHU000059
database_cross_reference: OMIM:MTHU026541
database_cross_reference: RCD:P225.
database_cross_reference: SNM:M-20220
database_cross_reference: SNMI:D4-01520
database_cross_reference: SNOMEDCT_US:30915001
database_cross_reference: SNOMEDCT_US:44519006

Ollier disease
type: Class
subclass of: syndrome
PMOID: PMO:00025118
Subclass_of: syndrome
Synonym: CHONDROMATOSIS, UNILATERAL
Synonym: Congenital enchondromatosis
Synonym: DYSCHONDROPLASIA
Synonym: Disease, Ollier
Synonym: Disease, Ollier's
Synonym: Dyschondroplasia
Synonym: ENCHONDROMATOSIS, MULTIPLE
Synonym: ENCHONDROMATOSIS, MULTIPLE, OLLIER TYPE
Synonym: ENCHONDROSES, MULTIPLE, CARTILAGINOUS
Synonym: Enchondroma, Multiple
Tree Number: T10.1.3
database_cross_reference: CHV:0000004433
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:4625
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001315
database_cross_reference: HPO:HP:0005701
database_cross_reference: ICD10:Q78.4
database_cross_reference: ICD10AM:Q78.4
database_cross_reference: ICD10CM:Q78.4
database_cross_reference: MDR:10014642
database_cross_reference: MDR:10078027
database_cross_reference: MSH:D004687
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:756.4
database_cross_reference: NCI:C3008
database_cross_reference: NDFRT:N0000001091
database_cross_reference: OMIM:166000
database_cross_reference: RCD:XE1M8
database_cross_reference: SNM:D-5434
database_cross_reference: SNM:M-22530
database_cross_reference: SNMI:D4-01033
database_cross_reference: SNOMEDCT_US:16535008
database_cross_reference: SNOMEDCT_US:205469005
database_cross_reference: SNOMEDCT_US:268274005

hydranencephaly
type: Class
subclass of: anencephaly
PMOID: PMO:00028255
Subclass_of: anencephaly
Synonym: ABSENCE OF CEREBRAL HEMISPHERES CONGEN
Synonym: Absence of Cerebral Hemispheres, Congenital
Synonym: CEREBRAL HEMISPHERES ABSENCE CONGEN
Synonym: CONGEN ABSENCE OF CEREBRAL HEMISPHERES
Synonym: Cerebral Hemispheres, Absence, Congenital
Synonym: Congenital Absence of Cerebral Hemispheres
Synonym: Congenital absence of cerebral hemispheres
Synonym: Hydrancephaly
Synonym: Hydranencephalies
Synonym: Hydranencephaly
Tree Number: T10.4.1.6.1
database_cross_reference: CHV:0000006334
database_cross_reference: DO:DOID:4626
database_cross_reference: HPO:HP:0002324
database_cross_reference: ICD10CM:Q04.3
database_cross_reference: MDR:10073472
database_cross_reference: MEDCIN:36022
database_cross_reference: MSH:D006832
database_cross_reference: NCI:C98949
database_cross_reference: NCI_NICHD:C98949
database_cross_reference: NDFRT:N0000001562
database_cross_reference: OMIM:MTHU037416
database_cross_reference: RCD:P234.
database_cross_reference: SNMI:D4-91016
database_cross_reference: SNOMEDCT_US:30023002

benign mastocytoma
type: Class
subclass of: cell type benign neoplasm
PMOID: PMO:00027393
Subclass_of: cell type benign neoplasm
Synonym: Benign Mastocytoma
Synonym: MAST CELL TUMOR, BENIGN
Synonym: Mastocytoma
Synonym: Mastocytoma [Disease/Finding]
Synonym: Mastocytoma, Benign
Tree Number: T10.2.3.1.8
database_cross_reference: MSH:D034801
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3217
database_cross_reference: NCI_CDISC:C3217
database_cross_reference: NDFRT:N0000010930

multiple chemical sensitivity
type: Class
subclass of: syndrome
definition: A syndrome that is an adverse physical reaction to low levels of many common chemicals.
PMOID: PMO:00025244
Subclass_of: syndrome
Synonym: 20th century disease
Synonym: CHEM SENSITIVITIES MULTIPLE
Synonym: CHEM SENSITIVITY MULTIPLE
Synonym: Chemical Sensitivities, Multiple
Synonym: Chemical Sensitivity, Multiple
Synonym: Environmental Intolerance, Idiopathic
Synonym: Environmental Intolerances, Idiopathic
Synonym: IDIOPATHIC ENVIR INTOLERANCE
Synonym: IDIOPATHIC ENVIR INTOLERANCES
Synonym: Idiopathic Environmental Intolerance
Tree Number: T10.1.104
database_cross_reference: CHV:0000025068
database_cross_reference: DO:DOID:4661
database_cross_reference: MDR:10057865
database_cross_reference: MSH:D018777
database_cross_reference: NDFRT:N0000003852
database_cross_reference: SNOMEDCT_US:702772003

prostate disease
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029747
Subclass_of: male reproductive system disease
Synonym: 7-51 DISEASES OF THE PROSTATE
Synonym: DISEASES OF THE PROSTATE
Synonym: Disease of prostate
Synonym: Disease of prostate (disorder)
Synonym: Disease of prostate, NOS
Synonym: Disease, Prostatic
Synonym: Disease;prostate
Synonym: Diseases, Prostatic
Synonym: Disorder of prostate
Synonym: Disorder of prostate (disorder)
Tree Number: T10.8.1.3.3
database_cross_reference: BI:BI00459
database_cross_reference: CCPSS:0043276
database_cross_reference: CHV:0000010225
database_cross_reference: CSP:2587-6619
database_cross_reference: CST:PROSTAT DIS
database_cross_reference: CST:UG/MG/PROS
database_cross_reference: DO:DOID:47
database_cross_reference: ICD10:N42.9
database_cross_reference: ICD10AM:N42.9
database_cross_reference: ICD10CM:N42.9
database_cross_reference: ICD9CM:602.9
database_cross_reference: ICPC2P:Y99017
database_cross_reference: LCH_NW:sh85107607
database_cross_reference: MDR:10036956
database_cross_reference: MDR:10036957
database_cross_reference: MDR:10045823
database_cross_reference: MEDCIN:95370
database_cross_reference: MEDLINEPLUS:7
database_cross_reference: MSH:D011469
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26865
database_cross_reference: NDFRT:N0000002498
database_cross_reference: RCD:K22z.
database_cross_reference: RCD:X30Oh
database_cross_reference: SNM:D-6840
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D7-51000
database_cross_reference: SNOMEDCT_US:197979000
database_cross_reference: SNOMEDCT_US:30281009

mongolian spot
type: Class
subclass of: skin disease
PMOID: PMO:00033956
Subclass_of: skin disease
Synonym: Blue Sacral Spot
Synonym: Blue Spot, Mongolian
Synonym: Blue nevus
Synonym: Blue sacral spot
Synonym: Mongolian Blue Spot
Synonym: Mongolian Macula
Synonym: Mongolian Spot
Synonym: Mongolian Spot [Disease/Finding]
Synonym: Mongolian blue spot
Synonym: Mongolian macula
Tree Number: T10.8.12.2.37
database_cross_reference: CHV:0000025973
database_cross_reference: DO:DOID:4702
database_cross_reference: HPO:HP:0011369
database_cross_reference: HPO:HP:0100814
database_cross_reference: LCH_NW:sh85086821
database_cross_reference: MDR:10027815
database_cross_reference: MEDCIN:261560
database_cross_reference: MEDLINEPLUS:5402
database_cross_reference: MSH:D049328
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3945
database_cross_reference: NDFRT:N0000010939
database_cross_reference: OMIM:MTHU055776
database_cross_reference: RCD:PH35.
database_cross_reference: SNM:M-57220
database_cross_reference: SNMI:D4-40372
database_cross_reference: SNOMEDCT_US:157017000
database_cross_reference: SNOMEDCT_US:268355000
database_cross_reference: SNOMEDCT_US:40467008

somatoform disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.
PMOID: PMO:00028125
Subclass_of: disease of mental health
Synonym: 9-82 SOMATOFORM DISORDERS
Synonym: Disorder, Somatoform
Synonym: Disorders, Somatoform
Synonym: Medically Unexplained Syndrome
Synonym: Medically Unexplained Syndromes
Synonym: Psychogenic disorder NOS
Synonym: Psychogenic syndromes NOS
Synonym: Psychogenic syndromes NOS (disorder)
Synonym: SOMATOFORM DIS
Synonym: SOMATOFORM DISORDERS
Tree Number: T10.3.6
database_cross_reference: AOD:0000024008
database_cross_reference: CHV:0000011521
database_cross_reference: DO:DOID:4737
database_cross_reference: ICD10:F45
database_cross_reference: ICD10:F45.9
database_cross_reference: ICD10AM:F45
database_cross_reference: ICD10AM:F45.9
database_cross_reference: ICD10CM:F45
database_cross_reference: ICD10CM:F45.9
database_cross_reference: ICD9CM:300.8
database_cross_reference: LCH:U004385
database_cross_reference: LCH_NW:sh85124779
database_cross_reference: MDR:10037191
database_cross_reference: MDR:10054153
database_cross_reference: MEDCIN:32797
database_cross_reference: MSH:D013001
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:300.82
database_cross_reference: NCI:C34956
database_cross_reference: NDFRT:N0000002781
database_cross_reference: PSY:48628
database_cross_reference: RCD:E26..
database_cross_reference: RCD:E27zz
database_cross_reference: RCD:Eu45z
database_cross_reference: RCDSY:Eu45z
database_cross_reference: SNMI:D9-82000
database_cross_reference: SNOMEDCT_US:192035008
database_cross_reference: SNOMEDCT_US:192430009
database_cross_reference: SNOMEDCT_US:192437007
database_cross_reference: SNOMEDCT_US:31297008

male reproductive system disease
type: Class
subclass of: reproductive system disease
definition: A reproductive system disease that affects male reproductive organs.
PMOID: PMO:00029735
Subclass_of: reproductive system disease
Synonym: 7-50 DISEASES OF THE MALE GENITAL ORGANS: GENERAL TERMS
Synonym: DISEASES OF MALE GENITAL ORGANS
Synonym: DISEASES OF THE MALE GENITAL ORGANS
Synonym: DISEASES OF THE MALE GENITAL ORGANS: GENERAL TERMS
Synonym: Diseas/male genital organs
Synonym: Disease of male genital organ
Synonym: Disease of male genital organ (disorder)
Synonym: Disease of male genital organs, NOS
Synonym: Disease, Male Genital
Synonym: Disease;genital;M
Tree Number: T10.8.1.3
database_cross_reference: CHV:0000005444
database_cross_reference: CST:UG/MG
database_cross_reference: DO:DOID:48
database_cross_reference: ICD10:N40-N51.9
database_cross_reference: ICD10:N50.9
database_cross_reference: ICD10AM:N40-N51.9
database_cross_reference: ICD10AM:N50.9
database_cross_reference: ICD10CM:N50.9
database_cross_reference: ICD9CM:600-608.99
database_cross_reference: ICD9CM:608.9
database_cross_reference: ICPC2P:Y99005
database_cross_reference: MDR:10018145
database_cross_reference: MDR:10045810
database_cross_reference: MDR:10061177
database_cross_reference: MEDCIN:210528
database_cross_reference: MEDLINEPLUS:1360
database_cross_reference: MEDLINEPLUS:4280
database_cross_reference: MSH:D005832
database_cross_reference: NDFRT:N0000001324
database_cross_reference: PSY:29230
database_cross_reference: RCD:K2...
database_cross_reference: RCD:K2z..
database_cross_reference: RCD:Kyu6.
database_cross_reference: RCDSY:Kyu6.
database_cross_reference: SNMI:D7-50000
database_cross_reference: SNOMEDCT_US:155905004
database_cross_reference: SNOMEDCT_US:155933004
database_cross_reference: SNOMEDCT_US:155945008
database_cross_reference: SNOMEDCT_US:198089001
database_cross_reference: SNOMEDCT_US:198553004
database_cross_reference: SNOMEDCT_US:64557000

Gorham's disease
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones.
PMOID: PMO:00025225
Subclass_of: syndrome
Synonym: Bone Disease, Disappearing
Synonym: DISAPPEARING BONE DIS
Synonym: Disappearing Bone Disease
Synonym: Disappearing bone disease
Synonym: Disappearing bone disease (disorder)
Synonym: Essential Osteolyses
Synonym: Essential Osteolysis
Synonym: Gorham disease
Synonym: Osteolyses, Essential
Synonym: Osteolysis, Essential
Tree Number: T10.1.89
database_cross_reference: DO:DOID:4837
database_cross_reference: MSH:D010015
database_cross_reference: NDFRT:N0000002252
database_cross_reference: RCD:X70Az
database_cross_reference: SNOMEDCT_US:240161003

Colorado tick fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue.
PMOID: PMO:00029445
Subclass_of: viral infectious disease
Synonym: Tick fever, American mountain
Tree Number: T10.7.2.76
database_cross_reference: DO:DOID:4885

adenocarcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that derives_from epithelial cells of glandular origin.
PMOID: PMO:00027285
Subclass_of: in situ carcinoma
Synonym: AIS - Adenocarcinoma in situ
Synonym: Adenocarcinoma In Situ
Synonym: Adenocarcinoma in Situ
Synonym: Adenocarcinoma in Situ [Disease/Finding]
Synonym: Adenocarcinoma in Situs
Synonym: Adenocarcinoma in situ
Synonym: Adenocarcinoma in situ (morphologic abnormality)
Synonym: Adenocarcinoma in situ NOS
Synonym: Adenocarcinoma in situ, NOS
Synonym: Adenocarcinoma in-situ
Tree Number: T10.2.2.3.4
database_cross_reference: CHV:0000029950
database_cross_reference: DO:DOID:4943
database_cross_reference: ICD10AM:M8140/2
database_cross_reference: MEDCIN:271386
database_cross_reference: MSH:D065311
database_cross_reference: NCI:C4123
database_cross_reference: NDFRT:N0000191024
database_cross_reference: RCD:BB51.
database_cross_reference: SNM:M-8140/2
database_cross_reference: SNMI:M-81402
database_cross_reference: SNOMEDCT_US:51642000

postpoliomyelitis syndrome
type: Class
subclass of: poliomyelitis
definition: A poliomyelitis that results in atrophy located in muscle, many years after the initial infection, has material basis in Human poliovirus 1, has material basis in Human poliovirus 2, or has material basis in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has symptom muscle weakness, has symptom muscle pain, has symptom sleep apnea, and has symptom breathing problems.
PMOID: PMO:00029406
Subclass_of: poliomyelitis
Synonym: MUSCULAR ATROPHY POSTPOLIO
Synonym: Muscular Atrophies, Post-Poliomyelitis
Synonym: Muscular Atrophies, Postpoliomyelitis
Synonym: Muscular Atrophy, Post-Poliomyelitis
Synonym: Muscular Atrophy, Postpoliomyelitis
Synonym: POST POLIO MUSCULAR ATROPHY
Synonym: POST POLIO SYNDROME
Synonym: POSTPOLIO SYNDROME
Synonym: PPMA
Synonym: Post Poliomyelitis Muscular Atrophy
Tree Number: T10.7.2.47.2
database_cross_reference: CHV:0000015282
database_cross_reference: CSP:2042-5623
database_cross_reference: DO:DOID:4952
database_cross_reference: DXP:U001569
database_cross_reference: ICD10CM:G14
database_cross_reference: ICPC2P:N70001
database_cross_reference: MDR:10036239
database_cross_reference: MEDCIN:35779
database_cross_reference: MEDLINEPLUS:365
database_cross_reference: MSH:D016262
database_cross_reference: NDFRT:N0000003388
database_cross_reference: RCD:X002p
database_cross_reference: SNMI:DE-35015
database_cross_reference: SNOMEDCT_US:31097004
database_cross_reference: SNOMEDCT_US:367094007

poliomyelitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in destruction located in motor neurons, has material basis in Human poliovirus 1, has material basis in Human poliovirus 2, or has material basis in Human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom vomiting, has symptom fatigue, has symptom neck stiffness, has symptom muscle spasms, and has symptom acute flaccid paralysis.
PMOID: PMO:00029404
Subclass_of: viral infectious disease
Synonym: Acute Poliomyelitis
Synonym: Acute Poliomyelitis, Epidemic
Synonym: Acute poliomyelitis
Synonym: Acute poliomyelitis (disorder)
Synonym: Acute poliomyelitis NOS
Synonym: Acute poliomyelitis NOS (disorder)
Synonym: Acute poliomyelitis, NOS
Synonym: Acute poliomyelitis, unspecified
Synonym: Acute poliomyelitis,unspcfd
Synonym: Acute unspecified poliomyelitis
Tree Number: T10.7.2.47
database_cross_reference: AOD:0000004824
database_cross_reference: BI:BI00556
database_cross_reference: CCPSS:0034153
database_cross_reference: CCPSS:0039873
database_cross_reference: CHV:0000009892
database_cross_reference: COSTAR:593
database_cross_reference: CSP:2042-5623
database_cross_reference: CST:INFECT
database_cross_reference: DO:DOID:4953
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001544
database_cross_reference: DXP:U003187
database_cross_reference: ICD10:A80
database_cross_reference: ICD10:A80.9
database_cross_reference: ICD10AM:A80
database_cross_reference: ICD10AM:A80.9
database_cross_reference: ICD10CM:A80
database_cross_reference: ICD10CM:A80.9
database_cross_reference: ICD9CM:045
database_cross_reference: ICD9CM:045.9
database_cross_reference: ICPC2EENG:N70
database_cross_reference: ICPC2P:N70004
database_cross_reference: LCH:U003746
database_cross_reference: LCH_NW:sh85104268
database_cross_reference: LNC:LA17016-9
database_cross_reference: MDR:10001003
database_cross_reference: MDR:10001009
database_cross_reference: MDR:10001100
database_cross_reference: MDR:10036008
database_cross_reference: MDR:10036009
database_cross_reference: MDR:10036012
database_cross_reference: MDR:10036013
database_cross_reference: MDR:10036014
database_cross_reference: MDR:10036016
database_cross_reference: MDR:10072661
database_cross_reference: MEDCIN:31022
database_cross_reference: MEDLINEPLUS:365
database_cross_reference: MSH:D011051
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35550
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NICHD:C35550
database_cross_reference: NDFRT:N0000002449
database_cross_reference: OMIM:MTHU014245
database_cross_reference: PSY:39300
database_cross_reference: RCD:A40..
database_cross_reference: RCD:A40z.
database_cross_reference: RCD:Ayu81
database_cross_reference: RCD:Xa97c
database_cross_reference: RCDSY:Ayu81
database_cross_reference: SNM:D-0450
database_cross_reference: SNMI:DE-35010
database_cross_reference: SNOMEDCT_US:154320008
database_cross_reference: SNOMEDCT_US:186475007
database_cross_reference: SNOMEDCT_US:186481004
database_cross_reference: SNOMEDCT_US:187390004
database_cross_reference: SNOMEDCT_US:266189002
database_cross_reference: SNOMEDCT_US:367318001
database_cross_reference: SNOMEDCT_US:398102009
database_cross_reference: SNOMEDCT_US:398256009
database_cross_reference: SNOMEDCT_US:54839009

bone marrow disease
type: Class
subclass of: hematopoietic system disease
PMOID: PMO:00033415
Subclass_of: hematopoietic system disease
Synonym: BONE MARROW DIS
Synonym: Bone Marrow Disease
Synonym: Bone Marrow Diseases
Synonym: Bone Marrow Diseases [Disease/Finding]
Synonym: Bone Marrow Disorder
Synonym: Bone marrow disease
Synonym: Bone marrow disorder
Synonym: Bone marrow disorder (disorder)
Synonym: Bone marrow disorder NOS
Synonym: Bone marrow--Diseases
Tree Number: T10.8.10.7
database_cross_reference: AOD:0000005868
database_cross_reference: CHV:0000002074
database_cross_reference: CSP:0427-3773
database_cross_reference: DO:DOID:4961
database_cross_reference: HPO:HP:0005561
database_cross_reference: LCH_NW:sh85081540
database_cross_reference: MDR:10050910
database_cross_reference: MDR:10061729
database_cross_reference: MEDLINEPLUS:171
database_cross_reference: MSH:D001855
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34433
database_cross_reference: NDFRT:N0000000589
database_cross_reference: SNOMEDCT_US:127035006

neurotic disorder
type: Class
subclass of: anxiety disorder
definition: An anxiety disorder that involves discress but neither delusions nor hallucinations.
PMOID: PMO:00028235
Subclass_of: anxiety disorder
Synonym: DEPRESSION REACTIVE
Synonym: Depression reactive
Synonym: Depression, Reactive
Synonym: Depression;reactive
Synonym: Depressions, Reactive
Synonym: Depressive Reaction (Neurotic)
Synonym: Depressive reaction
Synonym: Neurotic (reactive) depression
Synonym: Neurotic Depressive Reaction
Synonym: Neurotic depression reactive type
Tree Number: T10.3.12.5.8
database_cross_reference: AOD:0000023954
database_cross_reference: AOD:0000023956
database_cross_reference: BI:BI00676
database_cross_reference: CCPSS:1011063
database_cross_reference: CHV:0000003781
database_cross_reference: COSTAR:U000581
database_cross_reference: CSP:2483-6681
database_cross_reference: CST:DEPRESSION
database_cross_reference: DO:DOID:4964
database_cross_reference: DXP:U001648
database_cross_reference: ICPC2P:P76010
database_cross_reference: MDR:10012395
database_cross_reference: MDR:10012406
database_cross_reference: MDR:10037998
database_cross_reference: MEDCIN:315995
database_cross_reference: MSH:D000275
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:300.4
database_cross_reference: NCI:C34533
database_cross_reference: PSY:13670
database_cross_reference: PSY:33910
database_cross_reference: PSY:43020
database_cross_reference: RCD:XE1YC
database_cross_reference: SNMI:F-0B330
database_cross_reference: SNOMEDCT_US:154889000
database_cross_reference: SNOMEDCT_US:191740008
database_cross_reference: SNOMEDCT_US:192372006
database_cross_reference: SNOMEDCT_US:268753005
database_cross_reference: SNOMEDCT_US:87414006

Gerstmann syndrome
type: Class
subclass of: nervous system disease
definition: A nervous system disease that results_from damage located_in left parietal lobe, has_symptom agraphia, has_symptom acalculia, has_symptom finger agnosia.
PMOID: PMO:00029887
Subclass_of: nervous system disease
Synonym: ANGULAR GYRUS SYNDROME
Synonym: Aphasia-angular gyrus syndrome
Synonym: Aphasia-angular gyrus syndrome (disorder)
Synonym: Finger-Agnosia-Left-Right-Confusion-Acalculia-Agraphia
Synonym: Finger-Agnosia-Left-Right-Confusion-Acalculia-Agraphias
Synonym: GERSTMANN SYNDROME
Synonym: Gerstmann Badal Syndrome
Synonym: Gerstmann Syndrome
Synonym: Gerstmann Syndrome [Disease/Finding]
Synonym: Gerstmann's Syndrome
Tree Number: T10.8.2.2
database_cross_reference: CHV:0000005475
database_cross_reference: DO:DOID:4969
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000708
database_cross_reference: MDR:10048608
database_cross_reference: MSH:D005862
database_cross_reference: NDFRT:N0000001328
database_cross_reference: SNM:D-8556
database_cross_reference: SNMI:DA-13600
database_cross_reference: SNOMEDCT_US:36785009

actinobacillosis
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.
PMOID: PMO:00029602
Subclass_of: commensal bacterial infectious disease
Synonym: Actinobacilloses
Synonym: Actinobacillosis
Synonym: Actinobacillosis [Disease/Finding]
Synonym: Actinobacillosis, NOS
Tree Number: T10.7.3.3.3
database_cross_reference: DO:DOID:4974
database_cross_reference: MSH:D000187
database_cross_reference: NDFRT:N0000000297
database_cross_reference: SNMI:DE-11C00
database_cross_reference: SNOMEDCT_US:16140007

lymphedema
type: Class
subclass of: lymphatic system disease
PMOID: PMO:00032913
Subclass_of: lymphatic system disease
Synonym: Acquired lymphedema
Synonym: Acquired lymphoedema
Synonym: Edema, lymphatic
Synonym: LYMPH EDEMA
Synonym: LYMPHEDEMA
Synonym: LYMPHOEDEMA
Synonym: Lymphatic edema
Synonym: Lymphatic edema (morphologic abnormality)
Synonym: Lymphatic oedema
Synonym: Lymphedema
Tree Number: T10.8.6.4.1
database_cross_reference: CCPSS:0043480
database_cross_reference: CHV:0000007605
database_cross_reference: CHV:0000058161
database_cross_reference: COSTAR:U000427
database_cross_reference: CSP:0427-8617
database_cross_reference: CST:LYMPHEDEMA
database_cross_reference: DO:DOID:4977
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002471
database_cross_reference: HPO:HP:0001004
database_cross_reference: ICPC2P:K99012
database_cross_reference: LCH:U002758
database_cross_reference: LCH_NW:sh85079142
database_cross_reference: LNC:LP209077-9
database_cross_reference: MDR:10025233
database_cross_reference: MDR:10025282
database_cross_reference: MDR:10025284
database_cross_reference: MDR:10052790
database_cross_reference: MEDCIN:298087
database_cross_reference: MEDCIN:33312
database_cross_reference: MEDLINEPLUS:4610
database_cross_reference: MSH:D008209
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:457.1
database_cross_reference: NCI:C3207
database_cross_reference: NCI_CTCAE:E13802
database_cross_reference: NCI_NCI-GLOSS:CDR0000045359
database_cross_reference: NDFRT:N0000001900
database_cross_reference: OMIM:MTHU001042
database_cross_reference: PDQ:CDR0000041348
database_cross_reference: RCD:G8611
database_cross_reference: RCD:X206w
database_cross_reference: RCDAE:G8611
database_cross_reference: RCDAE:X206w
database_cross_reference: SNM:M-36660
database_cross_reference: SNMI:M-36460
database_cross_reference: SNOMEDCT_US:155485008
database_cross_reference: SNOMEDCT_US:195486001
database_cross_reference: SNOMEDCT_US:234097001
database_cross_reference: SNOMEDCT_US:266334008
database_cross_reference: SNOMEDCT_US:30213001

nonparalytic poliomyelitis
type: Class
subclass of: poliomyelitis
definition: A poliomyelitis that results in destruction located in motor neurons, has material basis in Human poliovirus 1, has material basis in Human poliovirus 2, or has material basis in Human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom vomiting, has symptom fatigue, has symptom neck stiffness, and has symptom muscle spasms.
PMOID: PMO:00029405
Subclass_of: poliomyelitis
Synonym: Acute non-paralytic polio
Synonym: Acute non-paralytic poliomyelitis
Synonym: Acute non-paralytic poliomyelitis, unspecified type poliovirus
Synonym: Acute nonparalytic poliomyelitis
Synonym: Acute nonparalytic poliomyelitis (disorder)
Synonym: Acute nonparalytic poliomyelitis, poliovirus, unspecified type
Synonym: Acute nonparalytic poliomyelitis, unspecified type poliovirus
Synonym: Anterior acute poliomyelitis specified as nonparalytic
Synonym: Anterior acute poliomyelitis, nonparalytic
Synonym: Epidemic acute poliomyelitis specified as non paralytic
Tree Number: T10.7.2.47.1
database_cross_reference: DO:DOID:4986
database_cross_reference: ICD10:A80.4
database_cross_reference: ICD10AM:A80.4
database_cross_reference: ICD10CM:A80.4
database_cross_reference: ICD9CM:045.2
database_cross_reference: ICD9CM:045.20
database_cross_reference: MDR:10000941
database_cross_reference: MDR:10000945
database_cross_reference: MDR:10057690
database_cross_reference: MDR:10057694
database_cross_reference: RCD:A402.
database_cross_reference: SNMI:DE-35013
database_cross_reference: SNOMEDCT_US:14535005

pancreatitis
type: Class
subclass of: pancreas disease
PMOID: PMO:00033196
Subclass_of: pancreas disease
Synonym: Already mapped above AAHA ID #: 933
Synonym: Inflammation of pancreas
Synonym: PANCREATITIS
Synonym: Pancreas inflamed
Synonym: Pancreatic inflammation
Synonym: Pancreatitides
Synonym: Pancreatitis
Synonym: Pancreatitis (disorder)
Synonym: Pancreatitis NOS
Synonym: Pancreatitis [Disease/Finding]
Tree Number: T10.8.8.4.2
database_cross_reference: AOD:0000005653
database_cross_reference: BI:BI00283
database_cross_reference: CCPSS:1018050
database_cross_reference: CHV:0000009229
database_cross_reference: COSTAR:550
database_cross_reference: CSP:2202-0236
database_cross_reference: CST:PANCREATITIS
database_cross_reference: DO:DOID:4989
database_cross_reference: DXP:U003003
database_cross_reference: HPO:HP:0001733
database_cross_reference: ICD10CM:K85.9
database_cross_reference: ICPC2P:D99043
database_cross_reference: LCH:U003457
database_cross_reference: LCH_NW:sh85097387
database_cross_reference: LNC:LA15860-2
database_cross_reference: MDR:10033645
database_cross_reference: MDR:10033656
database_cross_reference: MDR:10076039
database_cross_reference: MEDCIN:276522
database_cross_reference: MEDLINEPLUS:5876
database_cross_reference: MSH:D010195
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:577.0
database_cross_reference: NCI:C3306
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CTCAE:E10930
database_cross_reference: NCI_NCI-GLOSS:CDR0000045106
database_cross_reference: NCI_NICHD:C3306
database_cross_reference: NDFRT:N0000002290
database_cross_reference: OMIM:MTHU003881
database_cross_reference: RCD:X308h
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D5-90100
database_cross_reference: SNOMEDCT_US:197461009
database_cross_reference: SNOMEDCT_US:393591004
database_cross_reference: SNOMEDCT_US:75694006
database_cross_reference: SNOMEDCT_VET:75694006

thyroid gland disease
type: Class
subclass of: endocrine system disease
definition: An endocrine system disease that is located_in the thyroid.
PMOID: PMO:00033156
Subclass_of: endocrine system disease
Synonym: Abnormality of the thyroid gland
Synonym: B-80 HYPOTHYROIDISM, HYPERTHYROIDISM AND OTHER DISORDERS
Synonym: DISEASES OF THE THYROID GLAND
Synonym: DISORDER THYROID
Synonym: DISORDERS OF THYROID GLAND
Synonym: Disease of thyroid gland
Synonym: Disease of thyroid gland (disorder)
Synonym: Disease of thyroid gland, NOS
Synonym: Disease, Thyroid
Synonym: Diseases of Thyroid Gland
Tree Number: T10.8.8.3
database_cross_reference: AOD:0000005981
database_cross_reference: CCPSS:0034188
database_cross_reference: CCPSS:0056633
database_cross_reference: CHV:0000012259
database_cross_reference: CHV:0000048209
database_cross_reference: COSTAR:U000061
database_cross_reference: COSTAR:U000674
database_cross_reference: CSP:2928-6228
database_cross_reference: CST:ENDO/THYR
database_cross_reference: CST:THYR DIS
database_cross_reference: DO:DOID:12176
database_cross_reference: DO:DOID:50
database_cross_reference: HPO:HP:0000820
database_cross_reference: ICD10:E00-E07.9
database_cross_reference: ICD10:E07.9
database_cross_reference: ICD10AM:E00-E07.9
database_cross_reference: ICD10AM:E07.9
database_cross_reference: ICD10CM:E00-E07
database_cross_reference: ICD10CM:E07.9
database_cross_reference: ICD9CM:240-246.99
database_cross_reference: ICD9CM:246.9
database_cross_reference: LCH_NW:sh85135167
database_cross_reference: LNC:LA15157-3
database_cross_reference: LNC:LA17778-4
database_cross_reference: MDR:10013274
database_cross_reference: MDR:10043709
database_cross_reference: MDR:10043710
database_cross_reference: MDR:10043739
database_cross_reference: MDR:10045832
database_cross_reference: MEDCIN:90715
database_cross_reference: MEDLINEPLUS:439
database_cross_reference: MSH:D013959
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26893
database_cross_reference: NDFRT:N0000002942
database_cross_reference: OMIM:MTHU018343
database_cross_reference: OMIM:MTHU053945
database_cross_reference: PSY:53090
database_cross_reference: RCD:C06z.
database_cross_reference: RCD:XE100
database_cross_reference: SNM:D-2180
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DB-80000
database_cross_reference: SNOMEDCT_US:14304000
database_cross_reference: SNOMEDCT_US:154649009
database_cross_reference: SNOMEDCT_US:190232008
database_cross_reference: SNOMEDCT_US:190311002
database_cross_reference: SNOMEDCT_US:191036006

melioidosis
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.
PMOID: PMO:00029579
Subclass_of: primary bacterial infectious disease
Synonym: Burkholderia pseudomallei infection
Synonym: Infection due to Burkholderia pseudomallei
Synonym: Infection due to Malleomyces pseudomallei
Synonym: Infection due to Pseudomonas pseudomallei
Synonym: Infection due to Pseudomonas pseudomallei NOS
Synonym: Infection due to Whitmore's bacillus
Synonym: Infection due to malleomyces pseudomallei
Synonym: MELIOIDOSIS
Synonym: Melioidoses
Synonym: Melioidosis
Tree Number: T10.7.3.1.35
database_cross_reference: CHV:0000007902
database_cross_reference: DO:DOID:5052
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001152
database_cross_reference: ICD10:A24.4
database_cross_reference: ICD10AM:A24.4
database_cross_reference: ICD10CM:A24.9
database_cross_reference: ICD9CM:025
database_cross_reference: ICPC2P:A78054
database_cross_reference: LCH:U002893
database_cross_reference: LCH_NW:sh85083417
database_cross_reference: MDR:10027165
database_cross_reference: MDR:10037137
database_cross_reference: MDR:10053031
database_cross_reference: MDR:10069748
database_cross_reference: MEDCIN:219941
database_cross_reference: MEDCIN:31006
database_cross_reference: MEDCIN:97367
database_cross_reference: MEDCIN:97369
database_cross_reference: MEDCIN:97370
database_cross_reference: MSH:D008554
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:025
database_cross_reference: NCI:C128336
database_cross_reference: NCI_NICHD:C128336
database_cross_reference: NDFRT:N0000001973
database_cross_reference: RCD:A25..
database_cross_reference: RCD:Ayu29
database_cross_reference: RCDSY:Ayu29
database_cross_reference: SNM:D-0139
database_cross_reference: SNMI:DE-11B50
database_cross_reference: SNOMEDCT_US:187306003
database_cross_reference: SNOMEDCT_US:34458001
database_cross_reference: SNOMEDCT_US:428111003

phencyclidine abuse
type: Class
subclass of: substance abuse
definition: A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences.
PMOID: PMO:00027918
Subclass_of: substance abuse
Synonym: Abuse, Angel Dust
Synonym: Abuse, PCP
Synonym: Abuse, Phencyclidine
Synonym: Angel Dust Abuse
Synonym: DRUG ABUSE ANGEL DUST
Synonym: DRUG ABUSE PCP
Synonym: PCP ADDICTION
Synonym: PCP Abuse
Synonym: PCP abuse
Synonym: PCP abuse (disorder)
Tree Number: T10.3.3.2.6
database_cross_reference: AOD:0000004242
database_cross_reference: CCPSS:0007722
database_cross_reference: CCPSS:1008469
database_cross_reference: CHV:0000009592
database_cross_reference: DO:DOID:5062
database_cross_reference: DXP:NOCODE
database_cross_reference: LCH:U003607
database_cross_reference: LCH_NW:sh85100667
database_cross_reference: MEDCIN:32704
database_cross_reference: MSH:D010623
database_cross_reference: MTHICD9:305.9
database_cross_reference: NDFRT:N0000002388
database_cross_reference: SNMI:D9-30900
database_cross_reference: SNOMEDCT_US:7071007

adjustment disorder
type: Class
subclass of: disease of mental health
PMOID: PMO:00028143
Subclass_of: disease of mental health
Synonym: 9-85 ADJUSTMENT DISORDERS
Synonym: ADJUSTMENT DIS
Synonym: ADJUSTMENT DISORDER
Synonym: ADJUSTMENT DISORDERS
Synonym: Adjustment Disorder
Synonym: Adjustment Disorders
Synonym: Adjustment Disorders [Disease/Finding]
Synonym: Adjustment disorder
Synonym: Adjustment disorder (disorder)
Synonym: Adjustment disorder NOS
Tree Number: T10.3.9
database_cross_reference: AOD:0000024064
database_cross_reference: CCPSS:0018034
database_cross_reference: CHV:0000000743
database_cross_reference: COSTAR:029
database_cross_reference: DSM-5:309.9
database_cross_reference: DSM-5:F43.20
database_cross_reference: ICD10:F43.2
database_cross_reference: ICD10AM:F43.2
database_cross_reference: ICD10CM:F43.2
database_cross_reference: ICD10CM:F43.20
database_cross_reference: ICPC2P:P02002
database_cross_reference: LCH_NW:sh89006058
database_cross_reference: MDR:10001295
database_cross_reference: MDR:10001301
database_cross_reference: MDR:10061621
database_cross_reference: MEDCIN:32845
database_cross_reference: MSH:D000275
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92191
database_cross_reference: NCI_NCI-GLOSS:CDR0000454697
database_cross_reference: NDFRT:N0000000319
database_cross_reference: PDQ:CDR0000257623
database_cross_reference: PSY:00855
database_cross_reference: RCD:E29..
database_cross_reference: SNM:F-93900
database_cross_reference: SNMI:D9-85000
database_cross_reference: SNMI:F-91700
database_cross_reference: SNOMEDCT_US:154942003
database_cross_reference: SNOMEDCT_US:17226007
database_cross_reference: SNOMEDCT_US:192041001
database_cross_reference: SNOMEDCT_US:192416004
database_cross_reference: SNOMEDCT_US:367487002
database_cross_reference: SNOMEDCT_US:63608001

ganglioglioma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that has_material_basis_in glial-type cells.
PMOID: PMO:00027416
Subclass_of: cell type benign neoplasm
Synonym: CNS ganglioglioma
Synonym: Ganglioglioma
Synonym: Ganglioglioma (disorder)
Synonym: Ganglioglioma (morphologic abnormality)
Synonym: Ganglioglioma [Disease/Finding]
Synonym: Ganglioglioma, no ICD-O subtype
Synonym: Ganglioglioma, no ICD-O subtype (morphologic abnormality)
Synonym: Ganglioglioma, no International Classification of Diseases for Oncology subtype
Synonym: Ganglioglioma, no International Classification of Diseases for Oncology subtype (morphologic abnormality)
Synonym: Gangliogliomas
Tree Number: T10.2.3.1.14
database_cross_reference: CHV:0000021042
database_cross_reference: CSP:2012-6589
database_cross_reference: DO:DOID:5078
database_cross_reference: ICD10AM:M9505/1
database_cross_reference: MDR:10017701
database_cross_reference: MSH:D018303
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3788
database_cross_reference: NCI:TCGA
database_cross_reference: NDFRT:N0000003767
database_cross_reference: RCD:BBc6.
database_cross_reference: SNM:M-9505/1
database_cross_reference: SNMI:M-95051
database_cross_reference: SNOMEDCT_US:87191000119100
database_cross_reference: SNOMEDCT_US:89880005

thoracic cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.
PMOID: PMO:00026217
Subclass_of: organ system cancer
Synonym: Neoplasm of Thorax
Synonym: Neoplasm of the Thorax
Synonym: Neoplasm of thorax
Synonym: Neoplasm of thorax (disorder)
Synonym: Neoplasm, Thoracic
Synonym: Neoplasms, Thoracic
Synonym: THORACIC NEOPL
Synonym: Thoracic Neoplasm
Synonym: Thoracic Neoplasms
Synonym: Thoracic Neoplasms [Disease/Finding]
Tree Number: T10.2.1.2.5
database_cross_reference: CHV:0000012205
database_cross_reference: CSP:2005-5041
database_cross_reference: DO:DOID:5093
database_cross_reference: MSH:D013899
database_cross_reference: NCI:C3406
database_cross_reference: NDFRT:N0000002927
database_cross_reference: RCD:X78eJ
database_cross_reference: RCDAE:X78eJ
database_cross_reference: SNOMEDCT_US:255058005

nutritional deficiency disease
type: Class
subclass of: nutrition disease
PMOID: PMO:00028901
Subclass_of: nutrition disease
Synonym: DEFIC DIS
Synonym: Deficiency Disease
Synonym: Deficiency Diseases
Synonym: Deficiency Diseases [Disease/Finding]
Synonym: Deficiency diseases
Synonym: Disease, Deficiency
Synonym: Diseases, Deficiency
Synonym: deficiencies disease
Synonym: deficiency disease
Synonym: deficiency diseases
Tree Number: T10.6.1.4.2
database_cross_reference: CHV:0000003659
database_cross_reference: DO:DOID:5113
database_cross_reference: LCH:U001286
database_cross_reference: LCH_NW:sh85036451
database_cross_reference: MSH:D003677
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000909

borna disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment.
PMOID: PMO:00029444
Subclass_of: viral infectious disease
Synonym: Enzootic encephalomyelitis
Tree Number: T10.7.2.75
database_cross_reference: DO:DOID:5154

endometrium carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the endometrium.
PMOID: PMO:00027290
Subclass_of: in situ carcinoma
Synonym: Ca endometrium stage 0
Synonym: Ca in situ of endometrium
Synonym: Cancer of endometrium stage 0
Synonym: Carcinoma endometrial stage 0
Synonym: Carcinoma in situ of endometrium
Synonym: Carcinoma in situ of endometrium (disorder)
Synonym: Endometrial cancer stage 0
Synonym: Endometrial carcinoma stage 0
Synonym: Endometrium
Synonym: cancer of the endometrium, stage 0
Tree Number: T10.2.2.3.9
database_cross_reference: DO:DOID:5172
database_cross_reference: ICD10:D07.0
database_cross_reference: ICD10AM:D07.0
database_cross_reference: ICD10CM:D07.0
database_cross_reference: MDR:10006872
database_cross_reference: MDR:10007066
database_cross_reference: MDR:10007345
database_cross_reference: MDR:10014737
database_cross_reference: MDR:10014748
database_cross_reference: MTH:U000698
database_cross_reference: PDQ:CDR0000038738
database_cross_reference: RCD:X78XP
database_cross_reference: SNMI:D7-F0532
database_cross_reference: SNOMEDCT_US:189343006
database_cross_reference: SNOMEDCT_US:92582009

ureteral obstruction
type: Class
subclass of: ureteral disease
subclass of: urinary tract obstruction
PMOID: PMO:00032957
Subclass_of: ureteral disease
Subclass_of: urinary tract obstruction
Synonym: OBSTRUCTION URETER
Synonym: Obstruction of ureter
Synonym: Obstruction ureter
Synonym: Obstruction, Ureteral
Synonym: Obstruction;ureter
Synonym: Obstructions, Ureteral
Synonym: Occlusion NOS of ureter
Synonym: Occlusion of ureter
Synonym: Occlusion of ureter (disorder)
Synonym: Occlusion of ureter NOS
Tree Number: T10.8.7.2.2
Tree Number: T10.8.7.5.4
database_cross_reference: CHV:0000012761
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:3045-8807
database_cross_reference: CST:HYDRONEPHROSIS
database_cross_reference: DXP:U001953
database_cross_reference: HPO:HP:0006000
database_cross_reference: ICPC2P:U99026
database_cross_reference: LCH_NW:sh85141376
database_cross_reference: MDR:10029970
database_cross_reference: MDR:10030007
database_cross_reference: MDR:10046381
database_cross_reference: MDR:10046406
database_cross_reference: MEDCIN:35768
database_cross_reference: MSH:D014517
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:593.4
database_cross_reference: NCI:C79802
database_cross_reference: NCI_NICHD:C79802
database_cross_reference: NDFRT:N0000003070
database_cross_reference: OMIM:MTHU007835
database_cross_reference: RCD:K134z
database_cross_reference: RCD:X30N3
database_cross_reference: SNMI:D7-11960
database_cross_reference: SNOMEDCT_US:197809003
database_cross_reference: SNOMEDCT_US:20018005
database_cross_reference: SNOMEDCT_US:268235003

urinary tract obstruction
type: Class
subclass of: urinary system disease
PMOID: PMO:00032955
Subclass_of: urinary system disease
Synonym: OBSTRUCTIVE UROPATHY
Synonym: OBSTRUCTIVE UROPATHY, NOS
Synonym: Obstructive Uropathy
Synonym: Obstructive uropathy
Synonym: Obstructive uropathy NOS
Synonym: Obstructive uropathy, NOS
Synonym: Obstructive uropathy, unspecified
Synonym: URINARY OBSTRUCTION
Synonym: URINARY TRACT OBSTRUCTION
Synonym: UROPATHY OBSTRUCTIVE
Tree Number: T10.8.7.2
database_cross_reference: CCPSS:1009355
database_cross_reference: CCPSS:1018268
database_cross_reference: CHV:0000018389
database_cross_reference: COSTAR:U000047
database_cross_reference: COSTAR:U000485
database_cross_reference: CSP:3045-9672
database_cross_reference: CST:URIN TRACT DIS
database_cross_reference: DO:DOID:5200
database_cross_reference: DXP:U004247
database_cross_reference: ICD10CM:N13.9
database_cross_reference: ICD9CM:599.6
database_cross_reference: ICD9CM:599.60
database_cross_reference: MDR:10029984
database_cross_reference: MDR:10046548
database_cross_reference: MDR:10046587
database_cross_reference: MDR:10046710
database_cross_reference: MDR:10061574
database_cross_reference: MEDCIN:279155
database_cross_reference: MEDCIN:279156
database_cross_reference: MEDCIN:34194
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:599.60
database_cross_reference: NCI:C3675
database_cross_reference: NCI:C79805
database_cross_reference: NCI_CTCAE:E13052
database_cross_reference: NCI_NICHD:C3675
database_cross_reference: NCI_NICHD:C79805
database_cross_reference: OMIM:MTHU036561
database_cross_reference: RCD:XE0e4
database_cross_reference: RCD:XaB9C
database_cross_reference: SNMI:D7-10040
database_cross_reference: SNOMEDCT_US:197936002
database_cross_reference: SNOMEDCT_US:266567006
database_cross_reference: SNOMEDCT_US:266636004
database_cross_reference: SNOMEDCT_US:7163005

fructose-1,6-bisphosphatase deficiency
type: Class
subclass of: carbohydrate metabolic disorder
definition: A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis.
PMOID: PMO:00029154
Subclass_of: carbohydrate metabolic disorder
Synonym: Deficiencies, Fructose-1,6-Bisphosphatase
Synonym: Deficiencies, Fructose-1,6-Diphosphatase
Synonym: Deficiencies, Fructose-Biphosphatase
Synonym: Deficiencies, Fructosediphosphatase
Synonym: Deficiency, Fructose-1,6-Bisphosphatase
Synonym: Deficiency, Fructose-1,6-Diphosphatase
Synonym: Deficiency, Fructose-Biphosphatase
Synonym: Deficiency, Fructosediphosphatase
Synonym: FBP1D
Synonym: FDP DEFIC
Tree Number: T10.6.2.11.14
database_cross_reference: DO:DOID:5204
database_cross_reference: ICD10CM:E74.19
database_cross_reference: MEDCIN:313591
database_cross_reference: MSH:D015319
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C128119
database_cross_reference: NDFRT:N0000003219
database_cross_reference: OMIM:229700
database_cross_reference: OMIM:611570
database_cross_reference: RCD:Xa0Yh
database_cross_reference: SNMI:D6-50630
database_cross_reference: SNOMEDCT_US:28183005

congenital disorder of glycosylation
type: Class
subclass of: carbohydrate metabolic disorder
definition: A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids.
PMOID: PMO:00029151
Subclass_of: carbohydrate metabolic disorder
Synonym: CARB DEFIC GLYCOPROTEIN SYNDROME
Synonym: CDG - Carbohydrate-deficient glycoprotein syndrome
Synonym: CDG-Carbohyd-def glycprot synd
Synonym: Carbohydr-defic glycoprot synd
Synonym: Carbohydrate Deficient Glycoprotein Syndrome
Synonym: Carbohydrate deficiency glycoprotein syndrome
Synonym: Carbohydrate deficient glycoprotein syndrome
Synonym: Carbohydrate-Deficient Glycoprotein Syndrome
Synonym: Carbohydrate-Deficient Glycoprotein Syndromes
Synonym: Carbohydrate-deficient glycoprotein syndrome
Tree Number: T10.6.2.11.13
database_cross_reference: DO:DOID:5212
database_cross_reference: MDR:10075892
database_cross_reference: MSH:D018981
database_cross_reference: NCI:C84615
database_cross_reference: NCI_NICHD:C84615
database_cross_reference: NDFRT:N0000003885
database_cross_reference: RCD:X40WK
database_cross_reference: SNOMEDCT_US:238049009

infertility
type: Class
subclass of: reproductive system disease
PMOID: PMO:00029734
Subclass_of: reproductive system disease
Synonym: Cannot achieve a pregnancy
Synonym: Difficulty conceiving
Synonym: INFERTILITY
Synonym: Infertile
Synonym: Infertile (finding)
Synonym: Infertility
Synonym: Infertility NOS
Synonym: Infertility [Disease/Finding]
Synonym: Infertility problem
Synonym: Infertility, NOS
Tree Number: T10.8.1.2
database_cross_reference: AOD:0000005861
database_cross_reference: AOD:0000023511
database_cross_reference: BI:BI00389
database_cross_reference: CCPSS:1007691
database_cross_reference: CHV:0000006699
database_cross_reference: CHV:0000042721
database_cross_reference: CHV:0000049943
database_cross_reference: COSTAR:416
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1138-0208
database_cross_reference: CST:FERTIL DEC FEM
database_cross_reference: DO:DOID:5223
database_cross_reference: DXP:U002093
database_cross_reference: DXP:U003802
database_cross_reference: HPO:HP:0000789
database_cross_reference: ICPC2P:W15001
database_cross_reference: ICPC2P:W15002
database_cross_reference: ICPC2P:W29009
database_cross_reference: ICPC2P:W29010
database_cross_reference: LCH:U002427
database_cross_reference: LCH_NW:sh85066087
database_cross_reference: MDR:10021926
database_cross_reference: MDR:10021930
database_cross_reference: MDR:10042012
database_cross_reference: MEDCIN:1085
database_cross_reference: MEDCIN:283389
database_cross_reference: MEDLINEPLUS:250
database_cross_reference: MSH:D007246
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3836
database_cross_reference: NCI_NCI-GLOSS:CDR0000046348
database_cross_reference: NCI_NCI-GLOSS:CDR0000046600
database_cross_reference: NCI_NCI-GLOSS:CDR0000304721
database_cross_reference: NDFRT:N0000001684
database_cross_reference: OMIM:MTHU006969
database_cross_reference: PDQ:CDR0000040782
database_cross_reference: PSY:25210
database_cross_reference: PSY:49810
database_cross_reference: RCD:X76Lv
database_cross_reference: RCD:Xa4Oh
database_cross_reference: SNM:F-30710
database_cross_reference: SNM:F-30760
database_cross_reference: SNMI:F-80410
database_cross_reference: SNMI:F-80500
database_cross_reference: SNOMEDCT_US:15296000
database_cross_reference: SNOMEDCT_US:162186008
database_cross_reference: SNOMEDCT_US:289179008
database_cross_reference: SNOMEDCT_US:8619003
database_cross_reference: SNOMEDCT_VET:8619003

human immunodeficiency virus infectious disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.
PMOID: PMO:00029352
Subclass_of: viral infectious disease
Synonym: DISEASES DUE TO IMMUNODEFICIENCY VIRUS
Synonym: E-363-365 DISEASES DUE TO IMMUNODEFICIENCY VIRUS
Synonym: HIV
Synonym: HIV - Human immunodeficiency virus infection
Synonym: HIV DISEASE
Synonym: HIV INFECT
Synonym: HIV INFECTION
Synonym: HIV Infection
Synonym: HIV Infections
Synonym: HIV Infections [Disease/Finding]
Tree Number: T10.7.2.6
database_cross_reference: AOD:0000004831
database_cross_reference: AOD:0000023173
database_cross_reference: BI:BI00011
database_cross_reference: CCPSS:0052409
database_cross_reference: CCPSS:1006431
database_cross_reference: CHV:0000006188
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1560-6305
database_cross_reference: CST:HIV SYND
database_cross_reference: DO:DOID:526
database_cross_reference: ICD10:B20-B24.9
database_cross_reference: ICD10:B24
database_cross_reference: ICD10AM:B20-B24.9
database_cross_reference: ICD10AM:B24
database_cross_reference: ICD10CM:B20
database_cross_reference: ICD10CM:B20-B20
database_cross_reference: ICD9CM:042
database_cross_reference: ICD9CM:042-042.99
database_cross_reference: ICPC2P:B90002
database_cross_reference: LCH_NW:sh91004036
database_cross_reference: LNC:LA12565-0
database_cross_reference: LNC:MTHU020829
database_cross_reference: MDR:10020160
database_cross_reference: MDR:10020161
database_cross_reference: MDR:10020172
database_cross_reference: MDR:10020441
database_cross_reference: MDR:10020443
database_cross_reference: MEDCIN:34816
database_cross_reference: MEDCIN:90238
database_cross_reference: MEDCIN:90240
database_cross_reference: MSH:D015658
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:042
database_cross_reference: NCI:C3108
database_cross_reference: NCI_NICHD:C3108
database_cross_reference: NDFRT:N0000003302
database_cross_reference: PSY:23083
database_cross_reference: PSY:23465
database_cross_reference: RCD:AyuC.
database_cross_reference: RCD:AyuCD
database_cross_reference: RCD:X70M6
database_cross_reference: RCDSY:AyuC.
database_cross_reference: RCDSY:AyuCD
database_cross_reference: SNMI:DE-36300
database_cross_reference: SNOMEDCT_US:123321001
database_cross_reference: SNOMEDCT_US:186705005
database_cross_reference: SNOMEDCT_US:187438009
database_cross_reference: SNOMEDCT_US:187453001
database_cross_reference: SNOMEDCT_US:86406008

intestinal disease
type: Class
subclass of: gastrointestinal system disease
definition: A gastrointestinal system disease that is located_in the intestine.
PMOID: PMO:00033526
Subclass_of: gastrointestinal system disease
Synonym: 5-40-45 DISEASES OF THE INTESTINAL TRACT
Synonym: Abnormality of the intestine
Synonym: BOWEL DISEASE
Synonym: Bowel Disorders
Synonym: DISEASES OF THE INTESTINAL TRACT
Synonym: DISEASES OF THE SMALL AND LARGE INTESTINES
Synonym: Disease of intestine
Synonym: Disease of intestine (disorder)
Synonym: Disease of intestine, NOS
Synonym: Disease of intestine, unspecified
Tree Number: T10.8.11.8
database_cross_reference: AOD:0000005614
database_cross_reference: AOD:0000023382
database_cross_reference: CCPSS:0011558
database_cross_reference: CHV:0000006853
database_cross_reference: CHV:0000030650
database_cross_reference: CSP:1248-5896
database_cross_reference: DO:DOID:5295
database_cross_reference: HPO:HP:0002242
database_cross_reference: ICD10:K63.9
database_cross_reference: ICD10AM:K63.9
database_cross_reference: ICD10CM:K63.9
database_cross_reference: ICD9CM:569.9
database_cross_reference: ICPC2P:D99052
database_cross_reference: LCH_NW:sh85067586
database_cross_reference: MDR:10045793
database_cross_reference: MEDCIN:335851
database_cross_reference: MEDLINEPLUS:194
database_cross_reference: MEDLINEPLUS:5446
database_cross_reference: MSH:D007410
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26801
database_cross_reference: NDFRT:N0000001698
database_cross_reference: OMIM:MTHU003979
database_cross_reference: PSY:06680
database_cross_reference: RCD:J5z..
database_cross_reference: RCD:X302f
database_cross_reference: SNMI:D5-40000
database_cross_reference: SNOMEDCT_US:155629009
database_cross_reference: SNOMEDCT_US:197266001
database_cross_reference: SNOMEDCT_US:266483008
database_cross_reference: SNOMEDCT_US:85919009

pituitary gland disease
type: Class
subclass of: endocrine system disease
definition: An endocrine system disease that is located_in the pituitary gland.
PMOID: PMO:00033209
Subclass_of: endocrine system disease
Synonym: Abnormality of the pituitary gland
Synonym: B-10 GENERAL PITUITARY DISORDERS
Synonym: DISEASES OF THE PITUITARY GLAND
Synonym: Disease of pituitary gland
Synonym: Disease of pituitary gland (disorder)
Synonym: Disease of pituitary gland, NOS
Synonym: Disease, Pituitary
Synonym: Disease, Pituitary Gland
Synonym: Diseases, Pituitary
Synonym: Diseases, Pituitary Gland
Tree Number: T10.8.8.5
database_cross_reference: AOD:0000005971
database_cross_reference: CCPSS:1010133
database_cross_reference: CHV:0000009759
database_cross_reference: CSP:2335-8183
database_cross_reference: CST:ENDO/PIT
database_cross_reference: DO:DOID:53
database_cross_reference: HPO:HP:0011747
database_cross_reference: HPO:HP:0012503
database_cross_reference: ICD10:E23.7
database_cross_reference: ICD10AM:E23.7
database_cross_reference: ICD10CM:E23.7
database_cross_reference: LCH_NW:sh85102520
database_cross_reference: LNC:LA4684-2
database_cross_reference: MDR:10035082
database_cross_reference: MDR:10048593
database_cross_reference: MEDCIN:273528
database_cross_reference: MEDLINEPLUS:362
database_cross_reference: MSH:D010900
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:253.9
database_cross_reference: NCI:C26854
database_cross_reference: NDFRT:N0000002407
database_cross_reference: PSY:24040
database_cross_reference: PSY:38940
database_cross_reference: RCD:C13z.
database_cross_reference: RCD:XE10N
database_cross_reference: SNMI:DB-10000
database_cross_reference: SNOMEDCT_US:190495006
database_cross_reference: SNOMEDCT_US:267478007
database_cross_reference: SNOMEDCT_US:399244003
database_cross_reference: SNOMEDCT_US:88108008

thymus gland disease
type: Class
subclass of: lymphatic system disease
PMOID: PMO:00032941
Subclass_of: lymphatic system disease
Synonym: DISEASES OF THE THYMUS GLAND
Synonym: Disease of thymus NOS
Synonym: Disease of thymus gland
Synonym: Disease of thymus gland (disorder)
Synonym: Disease of thymus gland, NOS
Synonym: Disease of thymus, unspecified
Synonym: Diseases of thymus
Synonym: Diseases of thymus gland
Synonym: Disorder of thymus
Synonym: Disorder of thymus gland
Tree Number: T10.8.6.4.8
database_cross_reference: AOD:0000005961
database_cross_reference: CCPSS:0031640
database_cross_reference: CHV:0000017384
database_cross_reference: CSP:0427-9828
database_cross_reference: CST:ENDO/THYM
database_cross_reference: DO:DOID:533
database_cross_reference: ICD10:E32
database_cross_reference: ICD10:E32.9
database_cross_reference: ICD10AM:E32
database_cross_reference: ICD10AM:E32.9
database_cross_reference: ICD10CM:E32
database_cross_reference: ICD10CM:E32.9
database_cross_reference: ICD9CM:254
database_cross_reference: ICD9CM:254.9
database_cross_reference: MDR:10013137
database_cross_reference: MDR:10043677
database_cross_reference: MDR:10043678
database_cross_reference: MDR:10045760
database_cross_reference: MDR:10061381
database_cross_reference: MEDCIN:97103
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26962
database_cross_reference: RCD:C14..
database_cross_reference: RCD:C14z.
database_cross_reference: SNMI:DC-90000
database_cross_reference: SNOMEDCT_US:154703006
database_cross_reference: SNOMEDCT_US:190500009
database_cross_reference: SNOMEDCT_US:20673009
database_cross_reference: SNOMEDCT_US:267482009

anterograde amnesia
type: Class
subclass of: amnestic disorder
definition: An amnestic disorder that involves the impaired or lost ability to memorize new things.
PMOID: PMO:00028217
Subclass_of: amnestic disorder
Synonym: AMNESIA ANTEROGRADE
Synonym: Amnesia, Anterograde
Synonym: Amnesia, Anterograde [Disease/Finding]
Synonym: Amnesias, Anterograde
Synonym: Antegrade amnesia
Synonym: Anterograde Amnesia
Synonym: Anterograde Amnesias
Synonym: Anterograde Memory Loss
Synonym: Anterograde Memory Losses
Synonym: Anterograde amnesia
Tree Number: T10.3.12.4.3
database_cross_reference: AOD:0000006363
database_cross_reference: CCPSS:0008775
database_cross_reference: CHV:0000023204
database_cross_reference: DO:DOID:5340
database_cross_reference: ICD10:R41.1
database_cross_reference: ICD10AM:R41.1
database_cross_reference: ICD10CM:R41.1
database_cross_reference: MDR:10002711
database_cross_reference: MEDCIN:338204
database_cross_reference: MSH:D020324
database_cross_reference: NDFRT:N0000004109
database_cross_reference: PSY:03015
database_cross_reference: RCD:R00z5
database_cross_reference: RCD:X75xZ
database_cross_reference: RCDSY:R00z5
database_cross_reference: SNMI:F-96022
database_cross_reference: SNOMEDCT_US:206789002
database_cross_reference: SNOMEDCT_US:88822006

sleep disorder
type: Class
subclass of: disease of mental health
PMOID: PMO:00027882
Subclass_of: disease of mental health
Synonym: 9-74 SLEEP DISORDERS
Synonym: DISORDER SLEEP
Synonym: Disorder sleep
Synonym: Disorder, Sleep
Synonym: Disorder;sleep
Synonym: Disorders, Sleep
Synonym: Disturbances, Sleep
Synonym: Problem;sleep
Synonym: SLEEP DIS
Synonym: SLEEP DISORDER
Tree Number: T10.3.1
database_cross_reference: AOD:0000006771
database_cross_reference: BI:BI00561
database_cross_reference: CCPSS:1012197
database_cross_reference: COSTAR:689
database_cross_reference: CSP:2056-7094
database_cross_reference: CST:SLEEP DIS
database_cross_reference: ICD10:G47
database_cross_reference: ICD10:G47.9
database_cross_reference: ICD10AM:G47
database_cross_reference: ICD10AM:G47.9
database_cross_reference: ICD10CM:G47
database_cross_reference: ICD10CM:G47.9
database_cross_reference: ICPC2P:P06011
database_cross_reference: ICPC2P:P06012
database_cross_reference: LCH:U004342
database_cross_reference: LCH_NW:sh85123404
database_cross_reference: MDR:10013268
database_cross_reference: MDR:10040984
database_cross_reference: MDR:10040989
database_cross_reference: MDR:10040991
database_cross_reference: MDR:10041005
database_cross_reference: MDR:10048530
database_cross_reference: MEDCIN:338074
database_cross_reference: MEDLINEPLUS:408
database_cross_reference: MSH:D012893
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3376
database_cross_reference: NCI_FDA:2517
database_cross_reference: NCI_NCI-GLOSS:CDR0000454811
database_cross_reference: NCI_NCI-GLOSS:CDR0000454814
database_cross_reference: NCI_NICHD:C3376
database_cross_reference: NDFRT:N0000002774
database_cross_reference: OMIM:MTHU037343
database_cross_reference: OMIM:MTHU038215
database_cross_reference: PDQ:CDR0000041209
database_cross_reference: PSY:47840
database_cross_reference: RCD:R005z
database_cross_reference: RCD:X007q
database_cross_reference: RCD:XM06i
database_cross_reference: RCDSY:R005z
database_cross_reference: SNM:F-85830
database_cross_reference: SNMI:D9-74000
database_cross_reference: SNOMEDCT_US:154927001
database_cross_reference: SNOMEDCT_US:194436004
database_cross_reference: SNOMEDCT_US:206757006
database_cross_reference: SNOMEDCT_US:268775007
database_cross_reference: SNOMEDCT_US:39898005

colonic disease
type: Class
subclass of: intestinal disease
PMOID: PMO:00033608
Subclass_of: intestinal disease
Synonym: COLONIC DIS
Synonym: Colon
Synonym: Colon Disorders
Synonym: Colonic Disease
Synonym: Colonic Diseases
Synonym: Colonic Diseases [Disease/Finding]
Synonym: Disease of colon
Synonym: Disease of colon (disorder)
Synonym: Disease, Colonic
Synonym: Diseases, Colonic
Tree Number: T10.8.11.8.20
database_cross_reference: AOD:0000005629
database_cross_reference: CHV:0000003172
database_cross_reference: CSP:1248-3971
database_cross_reference: CST:DIG/COL
database_cross_reference: DO:DOID:5353
database_cross_reference: MEDLINEPLUS:194
database_cross_reference: MSH:D003108
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000811
database_cross_reference: PSY:10370
database_cross_reference: SNM:D-6250
database_cross_reference: SNOMEDCT_US:128524007

focal epithelial hyperplasia
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in mouth, has_material_basis_in human papillomavirus (types 13 or 32), has_symptom papules or nodules in the oral cavity.
PMOID: PMO:00029372
Subclass_of: viral infectious disease
Synonym: Disease, Heck
Synonym: Disease, Heck's
Synonym: Epithelial Hyperplasia, Focal
Synonym: Epithelial Hyperplasias, Focal
Synonym: FEH, ORAL
Synonym: FOCAL EPITHELIAL HYPERPLASIA, ORAL
Synonym: Focal Epithelial Hyperplasia
Synonym: Focal Epithelial Hyperplasia [Disease/Finding]
Synonym: Focal Epithelial Hyperplasia, Oral
Synonym: Focal Epithelial Hyperplasias
Tree Number: T10.7.2.22
database_cross_reference: DO:DOID:5362
database_cross_reference: MDR:10076576
database_cross_reference: MDR:10076577
database_cross_reference: MEDCIN:219306
database_cross_reference: MSH:D017573
database_cross_reference: NCI:C97083
database_cross_reference: NDFRT:N0000003607
database_cross_reference: OMIM:229045
database_cross_reference: RCD:J0871
database_cross_reference: SNMI:D5-21512
database_cross_reference: SNMI:M-72151
database_cross_reference: SNOMEDCT_US:36949004
database_cross_reference: SNOMEDCT_US:6121001

schizoaffective disorder
type: Class
subclass of: psychotic disorder
definition: A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.
PMOID: PMO:00028188
Subclass_of: psychotic disorder
Synonym: Disorder, Schizoaffective
Synonym: Disorders, Schizoaffective
Synonym: Psychosis;schizoaffective
Synonym: SCHIZO AFFECTIVE DISORDER
Synonym: SCHIZO AFFECTIVE DISORDER UNSPECIFIED
Synonym: SCHIZO AFFECTIVE SCHIZOPHRENIA
Synonym: SCHIZOAFFECTIVE DIS
Synonym: SCHIZOAFFECTIVE DISORDER
Synonym: Schizo-affective psychosis
Synonym: Schizo-affective type schizophrenia
Tree Number: T10.3.12.1.3
database_cross_reference: AOD:0000006502
database_cross_reference: AOD:0000023797
database_cross_reference: AOD:0000023801
database_cross_reference: BI:BI00689
database_cross_reference: CCPSS:0002057
database_cross_reference: CCPSS:1018206
database_cross_reference: CHV:0000011084
database_cross_reference: COSTAR:663
database_cross_reference: COSTAR:U000544
database_cross_reference: CSP:2483-6677
database_cross_reference: CSP:2485-0932
database_cross_reference: DO:DOID:5418
database_cross_reference: ICD10:F25
database_cross_reference: ICD10:F25.9
database_cross_reference: ICD10AM:F25
database_cross_reference: ICD10AM:F25.9
database_cross_reference: ICD10CM:F25
database_cross_reference: ICD10CM:F25.9
database_cross_reference: ICD9CM:295.7
database_cross_reference: ICPC2P:P72004
database_cross_reference: MDR:10039613
database_cross_reference: MDR:10039621
database_cross_reference: MDR:10039622
database_cross_reference: MDR:10039635
database_cross_reference: MEDCIN:32745
database_cross_reference: MEDCIN:350608
database_cross_reference: MSH:D011618
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:295.7
database_cross_reference: NCI:C94378
database_cross_reference: OMIM:181500
database_cross_reference: OMIM:615232
database_cross_reference: PSY:45427
database_cross_reference: RCD:E107.
database_cross_reference: RCD:E1070
database_cross_reference: RCD:E107z
database_cross_reference: RCD:Eu25.
database_cross_reference: RCD:Eu25z
database_cross_reference: RCDSY:Eu25z
database_cross_reference: SNM:D-9071
database_cross_reference: SNMI:D9-72030
database_cross_reference: SNOMEDCT_US:191567000
database_cross_reference: SNOMEDCT_US:191568005
database_cross_reference: SNOMEDCT_US:191575006
database_cross_reference: SNOMEDCT_US:192345003
database_cross_reference: SNOMEDCT_US:231490005
database_cross_reference: SNOMEDCT_US:68890003

schizophrenia
type: Class
subclass of: psychotic disorder
definition: A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.
PMOID: PMO:00028168
Subclass_of: psychotic disorder
Synonym: -- Schizophrenia
Synonym: Dementia Praecox
Synonym: Dementia praecox
Synonym: Disorder, Schizophrenic
Synonym: Disorders, Schizophrenic
Synonym: SCHIZOPHRENIA
Synonym: SCHIZOPHRENIAS
Synonym: SCHIZOPHRENIC DIS
Synonym: SCZD
Synonym: SECTION 9-4 SCHIZOPHRENIAS
Tree Number: T10.3.12.1.2
database_cross_reference: AOD:0000006486
database_cross_reference: AOD:0000006504
database_cross_reference: AOD:0000023755
database_cross_reference: BI:BI00690
database_cross_reference: CCPSS:0036486
database_cross_reference: CHV:0000011086
database_cross_reference: COSTAR:664
database_cross_reference: CSP:2485-0932
database_cross_reference: CST:SCHIZOPHRENIC REACT
database_cross_reference: DO:DOID:5419
database_cross_reference: DSM-5:295.90
database_cross_reference: DSM-5:F20.9
database_cross_reference: DXP:U001709
database_cross_reference: HPO:HP:0100753
database_cross_reference: ICD10:F20
database_cross_reference: ICD10:F20.9
database_cross_reference: ICD10AM:F20
database_cross_reference: ICD10AM:F20.9
database_cross_reference: ICD10CM:F20
database_cross_reference: ICD10CM:F20.9
database_cross_reference: ICD9CM:295
database_cross_reference: ICD9CM:295.9
database_cross_reference: ICD9CM:295.90
database_cross_reference: ICPC2EENG:P72
database_cross_reference: ICPC2P:P72011
database_cross_reference: LCH:U004232
database_cross_reference: LCH_NW:sh85118162
database_cross_reference: LNC:LA10584-3
database_cross_reference: LNC:MTHU020814
database_cross_reference: MDR:10012297
database_cross_reference: MDR:10039626
database_cross_reference: MDR:10039632
database_cross_reference: MDR:10039642
database_cross_reference: MDR:10046150
database_cross_reference: MDR:10046156
database_cross_reference: MEDCIN:350601
database_cross_reference: MEDCIN:35742
database_cross_reference: MEDLINEPLUS:392
database_cross_reference: MSH:D012559
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:295.9
database_cross_reference: MTHICD9:295.90
database_cross_reference: NCI:C3362
database_cross_reference: NCI_NCI-GLOSS:CDR0000450117
database_cross_reference: NDFRT:N0000002690
database_cross_reference: OMIM:181500
database_cross_reference: OMIM:MTHU015654
database_cross_reference: PSY:13430
database_cross_reference: PSY:45440
database_cross_reference: RCD:E10..
database_cross_reference: RCD:E1000
database_cross_reference: RCD:E10z.
database_cross_reference: RCD:Eu20.
database_cross_reference: RCD:Eu20z
database_cross_reference: RCDSY:Eu20z
database_cross_reference: SNM:D-9060
database_cross_reference: SNM:D-9089
database_cross_reference: SNM:U000021
database_cross_reference: SNMI:D9-40000
database_cross_reference: SNOMEDCT_US:154870000
database_cross_reference: SNOMEDCT_US:191526005
database_cross_reference: SNOMEDCT_US:191528006
database_cross_reference: SNOMEDCT_US:191579000
database_cross_reference: SNOMEDCT_US:192327003

conjunctival intraepithelial neoplasm
type: Class
subclass of: pre-malignant neoplasm
definition: A pre-malignant neoplasm that is characterized by abnormal growth of dysplastic squamous epithelial cells on the surface of the eye that arises from the conjunctiva that is restricted within the epithelium.
PMOID: PMO:00027280
Subclass_of: pre-malignant neoplasm
Synonym: CIN - conjunctival intraepithelial neoplasia
Synonym: Conjunctiva Intraepithelial Neoplasia
Synonym: Conjunctival Intraepithelial Neoplasia
Synonym: Conjunctival intraepithelial neoplasia
Synonym: Conjunctival intraepithelial neoplasia (disorder)
Synonym: Intraepithelial Neoplasia of Conjunctiva
Synonym: Intraepithelial Neoplasia of the Conjunctiva
Synonym: conjunctival intraepithelial neoplasia (diagnosis)
Tree Number: T10.2.2.2
database_cross_reference: DO:DOID:5465
database_cross_reference: MEDCIN:355379
database_cross_reference: NCI:C6120
database_cross_reference: SNOMEDCT_US:418134006

lice infestation
type: Class
subclass of: parasitic ectoparasitic infectious disease
definition: A parasitic ectoparasitic infectious disease that involves infestation of lice, which are blood-feeding ectoparasitic insects of the order Phthiraptera.
PMOID: PMO:00029719
Subclass_of: parasitic ectoparasitic infectious disease
Synonym: Infestation by Pediculus
Synonym: Lice infestation
Synonym: Louse infestation
Synonym: Pediculosis + lice
Synonym: Pediculosis and phthirus infection
Synonym: Pediculosis and phthirus infections
Synonym: Pediculosis and phthirus infestation
Synonym: mixed pediculosis
Synonym: mixed pediculosis infestation
Synonym: pediculosis
Tree Number: T10.7.4.4.2
database_cross_reference: DO:DOID:5502

kidney disease
type: Class
subclass of: urinary system disease
definition: A urinary system disease that is located_in the kidney.
PMOID: PMO:00032985
Subclass_of: urinary system disease
Synonym: DISORDER KIDNEY
Synonym: DISORDER RENAL
Synonym: Disease of kidney
Synonym: Disease, Kidney
Synonym: Diseases, Kidney
Synonym: Disorder kidney
Synonym: Disorder of kidney
Synonym: Disorder renal
Synonym: Disorder;kidney
Synonym: KIDNEY DIS
Tree Number: T10.8.7.9
database_cross_reference: AOD:0000005844
database_cross_reference: AOD:0000005849
database_cross_reference: AOD:0000023503
database_cross_reference: AOD:0000023505
database_cross_reference: BI:BI00447
database_cross_reference: BI:BI00465
database_cross_reference: CCPSS:0013357
database_cross_reference: CCPSS:1009001
database_cross_reference: CHV:0000007090
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000053
database_cross_reference: CSP:1681-9540
database_cross_reference: CST:RENAL
database_cross_reference: CST:RENALNOS
database_cross_reference: CST:UG/UT/K
database_cross_reference: CST:URIN TRACT DIS
database_cross_reference: DO:DOID:557
database_cross_reference: DXP:U002249
database_cross_reference: HPO:HP:0000077
database_cross_reference: HPO:HP:0000112
database_cross_reference: ICD10CM:N08
database_cross_reference: ICD10CM:N28.9
database_cross_reference: ICPC2P:U88001
database_cross_reference: ICPC2P:U99029
database_cross_reference: LCH_NW:sh85072261
database_cross_reference: LNC:LA10528-0
database_cross_reference: LNC:LA17773-5
database_cross_reference: MDR:10013231
database_cross_reference: MDR:10013263
database_cross_reference: MDR:10029149
database_cross_reference: MDR:10029151
database_cross_reference: MDR:10029154
database_cross_reference: MDR:10038428
database_cross_reference: MDR:10038429
database_cross_reference: MDR:10051051
database_cross_reference: MDR:10051052
database_cross_reference: MEDCIN:236575
database_cross_reference: MEDCIN:30627
database_cross_reference: MEDCIN:30690
database_cross_reference: MEDLINEPLUS:91
database_cross_reference: MSH:D007674
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:583.9
database_cross_reference: MTHICD9:593.9
database_cross_reference: NCI:C3149
database_cross_reference: NCI:C34843
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NICHD:C3149
database_cross_reference: NCI_NICHD:C34843
database_cross_reference: NDFRT:N0000001748
database_cross_reference: OMIM:MTHU036995
database_cross_reference: OMIM:MTHU047531
database_cross_reference: PSY:27347
database_cross_reference: PSY:43925
database_cross_reference: RCD:X30Hc
database_cross_reference: RCD:XM0sW
database_cross_reference: SNM:D-6502
database_cross_reference: SNMI:D7-11000
database_cross_reference: SNOMEDCT_US:155871008
database_cross_reference: SNOMEDCT_US:266612003
database_cross_reference: SNOMEDCT_US:266624005
database_cross_reference: SNOMEDCT_US:266627003
database_cross_reference: SNOMEDCT_US:274108006
database_cross_reference: SNOMEDCT_US:90708001

Beckwith-Wiedemann syndrome
type: Class
subclass of: syndrome
definition: A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations.
PMOID: PMO:00025117
Subclass_of: syndrome
Synonym: BECKWITH-WIEDEMANN SYNDROME
Synonym: BWS
Synonym: Beckwith Wiedemann Syndrome
Synonym: Beckwith syndrome
Synonym: Beckwith syndrome (diagnosis)
Synonym: Beckwith's syndrome
Synonym: Beckwith-Wiedemann Syndrome
Synonym: Beckwith-Wiedemann Syndrome [Disease/Finding]
Synonym: Beckwith-Wiedemann syndrome (BW, BWS)
Synonym: Beckwith-Wiedemann syndrome (disorder)
Tree Number: T10.1.2
database_cross_reference: CHV:0000001739
database_cross_reference: DO:DOID:5572
database_cross_reference: ICD10CM:Q87.3
database_cross_reference: JABL:52
database_cross_reference: MDR:10050344
database_cross_reference: MEDCIN:36918
database_cross_reference: MSH:D001506
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34415
database_cross_reference: NCI_NCI-GLOSS:CDR0000304689
database_cross_reference: NCI_NICHD:C34415
database_cross_reference: NDFRT:N0000000537
database_cross_reference: OMIM:130650
database_cross_reference: OMIM:600856
database_cross_reference: OMIM:604115
database_cross_reference: OMIM:606681
database_cross_reference: OMIM:616186
database_cross_reference: RCD:PKy91
database_cross_reference: SNM:D-5062
database_cross_reference: SNMI:D4-00503
database_cross_reference: SNOMEDCT_US:81780002

inhibited male orgasm
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029754
Subclass_of: male reproductive system disease
Synonym: Inhibited male orgasm
Synonym: Inhibited male orgasm (disorder)
Synonym: Male Orgasmic Disorder
Synonym: Male orgasmic disorder
Synonym: Psychogenic inhibited male orgasm
Synonym: Psychogenic inhibited male orgasm (finding)
Synonym: Psychosexual dysfunction with inhibited male orgasm
Synonym: inhibited male orgasmic disorder
Synonym: inhibited male orgasmic disorder (diagnosis)
Synonym: male Orgasmic disorder
Tree Number: T10.8.1.3.4
database_cross_reference: AOD:0000006821
database_cross_reference: DO:DOID:5576
database_cross_reference: ICD10CM:F52.32
database_cross_reference: MDR:10022033
database_cross_reference: MDR:10025513
database_cross_reference: MDR:10037227
database_cross_reference: MEDCIN:32824
database_cross_reference: MEDCIN:350045
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34959
database_cross_reference: RCD:E2275
database_cross_reference: SNMI:D9-73532
database_cross_reference: SNOMEDCT_US:153261000119109
database_cross_reference: SNOMEDCT_US:191795002
database_cross_reference: SNOMEDCT_US:81903006

Volkmann contracture
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032276
Subclass_of: connective tissue disease
Synonym: Contracture, Ischemic
Synonym: Contracture, Volkmann
Synonym: Contracture, Volkmann's Ischemic
Synonym: Contractures, Ischemic
Synonym: Contractures, Volkmann
Synonym: Ischemic Contracture
Synonym: Ischemic Contracture [Disease/Finding]
Synonym: Ischemic Contracture, Volkmann's
Synonym: Ischemic Contractures
Synonym: Volkmann Contracture
Tree Number: T10.8.4.1.9
database_cross_reference: CHV:0000013082
database_cross_reference: DO:DOID:5587
database_cross_reference: ICD10CM:T79.6
database_cross_reference: ICD9CM:958.6
database_cross_reference: ICPC2P:L99043
database_cross_reference: MDR:10047687
database_cross_reference: MDR:10047688
database_cross_reference: MEDCIN:310057
database_cross_reference: MEDCIN:7693
database_cross_reference: MSH:D054061
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35130
database_cross_reference: NDFRT:N0000181038
database_cross_reference: RCD:SK06.
database_cross_reference: RCDAE:SK06.
database_cross_reference: SNM:D-8049
database_cross_reference: SNM:M-58400
database_cross_reference: SNMI:D1-50434
database_cross_reference: SNOMEDCT_US:111247001
database_cross_reference: SNOMEDCT_US:157667008

nerve compression syndrome
type: Class
subclass of: peripheral nervous system disease
PMOID: PMO:00030153
Subclass_of: peripheral nervous system disease
Synonym: Compression Syndrome, Nerve
Synonym: Compression Syndromes, Nerve
Synonym: Compression neuropathy
Synonym: Entrapment Neuropathy
Synonym: Nerve Compression Syndrome
Synonym: Nerve Compression Syndromes
Synonym: Nerve Compression Syndromes [Disease/Finding]
Synonym: Nerve compression syndrome
Synonym: Syndrome, Nerve Compression
Synonym: Syndromes, Nerve Compression
Tree Number: T10.8.2.4.7
database_cross_reference: CHV:0000008594
database_cross_reference: DO:DOID:573
database_cross_reference: MSH:D009408
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002156

peripheral nervous system disease
type: Class
subclass of: nervous system disease
definition: A nervous system disease that affects the peripheral nervous system.
PMOID: PMO:00029889
Subclass_of: nervous system disease
Synonym: A-43-44 PERIPHERAL NERVE DISORDERS
Synonym: DISORDERS OF THE PERIPHERAL NERVOUS SYSTEM
Synonym: Disorder of Peripheral Nervous System
Synonym: Disorder of peripheral nervous system NOS
Synonym: Disorder of the peripheral nervous system
Synonym: Disorder of the peripheral nervous system (disorder)
Synonym: Disorder of the peripheral nervous system, NOS
Synonym: NEUROPATHY PERIPHERAL
Synonym: Nerve Disease, Peripheral
Synonym: Nerve Diseases, Peripheral
Tree Number: T10.8.2.4
database_cross_reference: AOD:0000006105
database_cross_reference: AOD:0000006111
database_cross_reference: AOD:0000023589
database_cross_reference: BI:BI00555
database_cross_reference: CCPSS:1014806
database_cross_reference: CHV:0000009515
database_cross_reference: COSTAR:575
database_cross_reference: CSP:2042-6505
database_cross_reference: CSP:2042-6617
database_cross_reference: CST:NEURITIS PERIPH
database_cross_reference: DO:DOID:574
database_cross_reference: DXP:U003097
database_cross_reference: HPO:HP:0000759
database_cross_reference: HPO:HP:0001271
database_cross_reference: HPO:HP:0009830
database_cross_reference: ICD10CM:G64
database_cross_reference: ICD9CM:350-359.99
database_cross_reference: ICPC2P:N94011
database_cross_reference: LCH_NW:sh85090904
database_cross_reference: MDR:10029331
database_cross_reference: MDR:10034606
database_cross_reference: MDR:10034610
database_cross_reference: MDR:10051174
database_cross_reference: MEDCIN:311304
database_cross_reference: MEDCIN:337549
database_cross_reference: MEDCIN:9438
database_cross_reference: MEDLINEPLUS:1095
database_cross_reference: MSH:D010523
database_cross_reference: MTH:516
database_cross_reference: MTH:575
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C119734
database_cross_reference: NCI:C27580
database_cross_reference: NCI_NCI-GLOSS:CDR0000044705
database_cross_reference: NCI_NICHD:C119734
database_cross_reference: NCI_NICHD:C27580
database_cross_reference: NDFRT:N0000002375
database_cross_reference: OMIM:MTHU000700
database_cross_reference: PSY:37560
database_cross_reference: RCD:F3...
database_cross_reference: RCD:F3z..
database_cross_reference: RCD:XC0eJ
database_cross_reference: RCD:Xa8I0
database_cross_reference: SNM:D-8X30
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DA-40000
database_cross_reference: SNMI:DA-43000
database_cross_reference: SNOMEDCT_US:155064004
database_cross_reference: SNOMEDCT_US:155080009
database_cross_reference: SNOMEDCT_US:155100008
database_cross_reference: SNOMEDCT_US:193088006
database_cross_reference: SNOMEDCT_US:193264002
database_cross_reference: SNOMEDCT_US:264554005
database_cross_reference: SNOMEDCT_US:267706009
database_cross_reference: SNOMEDCT_US:302226006
database_cross_reference: SNOMEDCT_US:42658009

proteinuria
type: Class
subclass of: kidney disease
PMOID: PMO:00033054
Subclass_of: kidney disease
Synonym: Proteinuria syndrome
Synonym: Proteinuria syndrome (disorder)
Synonym: Proteinuria syndrome (disorder) [Ambiguous]
Synonym: Proteinuria syndrome, NOS
Tree Number: T10.8.7.9.18
database_cross_reference: DO:DOID:576
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:D-6508
database_cross_reference: SNMI:D7-11250
database_cross_reference: SNOMEDCT_US:232691000
database_cross_reference: SNOMEDCT_US:367540006
database_cross_reference: SNOMEDCT_US:8925001

oral submucous fibrosis
type: Class
subclass of: mouth disease
PMOID: PMO:00033642
Subclass_of: mouth disease
Synonym: Fibroses, Oral Submucous
Synonym: Fibrosis, Oral Submucous
Synonym: Oral Submucous Fibroses
Synonym: Oral Submucous Fibrosis
Synonym: Oral Submucous Fibrosis [Disease/Finding]
Synonym: Oral submucosal fibrosis
Synonym: Oral submucosal fibrosis (disorder)
Synonym: Oral submucous fibrosis
Synonym: Submucous Fibroses, Oral
Synonym: Submucous Fibrosis, Oral
Tree Number: T10.8.11.11.3
database_cross_reference: CHV:0000008999
database_cross_reference: ICD10:K13.5
database_cross_reference: ICD10AM:K13.5
database_cross_reference: ICD10CM:K13.5
database_cross_reference: MDR:10031023
database_cross_reference: MSH:D009914
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002230
database_cross_reference: RCD:J088.
database_cross_reference: SNMI:D5-21520
database_cross_reference: SNOMEDCT_US:32883009

acute urate nephropathy
type: Class
subclass of: kidney disease
PMOID: PMO:00033041
Subclass_of: kidney disease
Synonym: Acute urate nephropathy
Synonym: Acute urate nephropathy (disorder)
Synonym: acute urate nephropathy (diagnosis)
Tree Number: T10.8.7.9.15
database_cross_reference: MEDCIN:30697
database_cross_reference: RCD:X30Kf
database_cross_reference: SNM:D-6597
database_cross_reference: SNOMEDCT_US:236496000

nephrolithiasis
type: Class
subclass of: kidney disease
PMOID: PMO:00033057
Subclass_of: kidney disease
Synonym: CALCULUS KIDNEY
Synonym: Calculi, Kidney
Synonym: Calculi, Renal
Synonym: Calculus kidney
Synonym: Calculus of kidney
Synonym: Calculus renal
Synonym: Calculus renal NOS
Synonym: Calculus, Kidney
Synonym: Calculus, Renal
Synonym: Calculus;kidney
Tree Number: T10.8.7.9.19
database_cross_reference: AOD:0000023508
database_cross_reference: BI:BI00446
database_cross_reference: CCPSS:0046981
database_cross_reference: CHV:0000007086
database_cross_reference: COSTAR:436
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0531-7858
database_cross_reference: CSP:1682-0486
database_cross_reference: CSP:1682-1409
database_cross_reference: CST:KIDNEY CALCULUS
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000972
database_cross_reference: DXP:U002255
database_cross_reference: ICD10:N20.0
database_cross_reference: ICD10AM:N20.0
database_cross_reference: ICD10CM:N20.0
database_cross_reference: ICD9CM:592.0
database_cross_reference: ICPC2P:U95005
database_cross_reference: ICPC2P:U95008
database_cross_reference: ICPC2P:U95009
database_cross_reference: LCH_NW:sh85072259
database_cross_reference: LNC:LA14297-8
database_cross_reference: LNC:LP232215-6
database_cross_reference: MDR:10006994
database_cross_reference: MDR:10007013
database_cross_reference: MDR:10007020
database_cross_reference: MDR:10007021
database_cross_reference: MDR:10023399
database_cross_reference: MDR:10023436
database_cross_reference: MDR:10023437
database_cross_reference: MDR:10038385
database_cross_reference: MDR:10038386
database_cross_reference: MDR:10038387
database_cross_reference: MDR:10038527
database_cross_reference: MEDLINEPLUS:1224
database_cross_reference: MSH:D007669
database_cross_reference: MTH:436
database_cross_reference: MTH:513
database_cross_reference: MTH:U002027
database_cross_reference: MTHICD9:592.0
database_cross_reference: NCI:C26807
database_cross_reference: NCI_CTCAE:E13018
database_cross_reference: NDFRT:N0000001746
database_cross_reference: OMIM:167030
database_cross_reference: OMIM:MTHU008708
database_cross_reference: OMIM:MTHU009703
database_cross_reference: OMIM:MTHU012690
database_cross_reference: RCD:K120z
database_cross_reference: RCD:XE0dk
database_cross_reference: SNM:M-30000
database_cross_reference: SNMI:D7-11061
database_cross_reference: SNOMEDCT_US:155867005
database_cross_reference: SNOMEDCT_US:155868000
database_cross_reference: SNOMEDCT_US:197792007
database_cross_reference: SNOMEDCT_US:197793002
database_cross_reference: SNOMEDCT_US:197795009
database_cross_reference: SNOMEDCT_US:266622009
database_cross_reference: SNOMEDCT_US:266623004
database_cross_reference: SNOMEDCT_US:56491003
database_cross_reference: SNOMEDCT_US:95570007
database_cross_reference: SNOMEDCT_VET:95570007

retroperitoneal cancer
type: Class
subclass of: organ system cancer
definition: An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum.
PMOID: PMO:00026617
Subclass_of: organ system cancer
Synonym: Neoplasm of retroperitoneum
Synonym: Neoplasm of retroperitoneum (disorder)
Synonym: Neoplasm of the retroperitoneum
Synonym: Neoplasm of the retroperitoneum (disorder)
Synonym: Neoplasm of the retroperitoneum [dup] (disorder)
Synonym: Neoplasm, Retroperitoneal
Synonym: Neoplasms, Retroperitoneal
Synonym: RETROPERITONEAL NEOPL
Synonym: RETROPERITONEAL NEOPLASM
Synonym: Retroperitoneal Neoplasm
Tree Number: T10.2.1.2.9
database_cross_reference: CCPSS:0022232
database_cross_reference: CSP:2005-3788
database_cross_reference: DO:DOID:5875
database_cross_reference: MDR:10056664
database_cross_reference: MEDCIN:31543
database_cross_reference: MSH:D012186
database_cross_reference: NCI:C3357
database_cross_reference: NDFRT:N0000002621
database_cross_reference: RCD:X78Ps
database_cross_reference: RCDAE:X78Ps
database_cross_reference: SNOMEDCT_US:126872008
database_cross_reference: SNOMEDCT_US:254617008
database_cross_reference: SNOMEDCT_US:359767009
database_cross_reference: SNOMEDCT_US:359770008

phobic disorder
type: Class
subclass of: anxiety disorder
definition: An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation.
PMOID: PMO:00028224
Subclass_of: anxiety disorder
Synonym: 946 PHOBIAS
Synonym: Abnormal fear
Synonym: Disorder, Phobic
Synonym: Disorders, Phobic
Synonym: Neuroses, Phobic
Synonym: Neurosis, phobic
Synonym: PHOBIA
Synonym: PHOBIAS
Synonym: PHOBIC DIS
Synonym: PHOBIC NEUROSIS
Tree Number: T10.3.12.5.5
database_cross_reference: AOD:0000006601
database_cross_reference: AOD:0000006604
database_cross_reference: AOD:0000023935
database_cross_reference: BI:BI00686
database_cross_reference: CHV:0000031209
database_cross_reference: COSTAR:583
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2483-6225
database_cross_reference: CST:NEUROSIS
database_cross_reference: DO:DOID:591
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001495
database_cross_reference: DXP:U003144
database_cross_reference: ICD10:F40
database_cross_reference: ICD10:F40.9
database_cross_reference: ICD10AM:F40
database_cross_reference: ICD10AM:F40.9
database_cross_reference: ICD10CM:F40
database_cross_reference: ICD10CM:F40.9
database_cross_reference: ICD9CM:300.2
database_cross_reference: ICD9CM:300.20
database_cross_reference: ICPC2P:P79009
database_cross_reference: ICPC2P:P79010
database_cross_reference: LCH_NW:sh85101017
database_cross_reference: MDR:10034912
database_cross_reference: MDR:10034915
database_cross_reference: MDR:10034916
database_cross_reference: MDR:10034917
database_cross_reference: MDR:10034919
database_cross_reference: MDR:10034920
database_cross_reference: MDR:10034922
database_cross_reference: MEDCIN:99990
database_cross_reference: MEDLINEPLUS:360
database_cross_reference: MSH:D010698
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:300.20
database_cross_reference: NCI:C35420
database_cross_reference: NCI_NCI-GLOSS:CDR0000454806
database_cross_reference: NDFRT:N0000002394
database_cross_reference: OMIM:MTHU031526
database_cross_reference: PSY:38280
database_cross_reference: PSY:38290
database_cross_reference: RCD:E2020
database_cross_reference: RCD:Eu40.
database_cross_reference: RCD:Eu40z
database_cross_reference: RCD:XE1YA
database_cross_reference: RCD:XE1YB
database_cross_reference: RCDSY:Eu40.
database_cross_reference: RCDSY:Eu40z
database_cross_reference: SNM:D-9235
database_cross_reference: SNM:F-92300
database_cross_reference: SNM:U000223
database_cross_reference: SNMI:D9-81000
database_cross_reference: SNMI:F-94600
database_cross_reference: SNOMEDCT_US:154884005
database_cross_reference: SNOMEDCT_US:191720001
database_cross_reference: SNOMEDCT_US:191721002
database_cross_reference: SNOMEDCT_US:191734001
database_cross_reference: SNOMEDCT_US:192393009
database_cross_reference: SNOMEDCT_US:192398000
database_cross_reference: SNOMEDCT_US:268630000
database_cross_reference: SNOMEDCT_US:386808001
database_cross_reference: SNOMEDCT_US:386810004
database_cross_reference: SNOMEDCT_US:52039009

panic disorder
type: Class
subclass of: anxiety disorder
definition: An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.
PMOID: PMO:00028233
Subclass_of: anxiety disorder
Synonym: -- Panic Disorder
Synonym: Disorder, Panic
Synonym: Disorder;panic
Synonym: Disorders, Panic
Synonym: Episodic paroxysmal anxiety disorder
Synonym: Episodic paroxysml anx disord
Synonym: PANIC DIS
Synonym: PANIC DISORDER
Synonym: Panic Disorder
Synonym: Panic Disorder [Disease/Finding]
Tree Number: T10.3.12.5.6
database_cross_reference: AOD:0000006573
database_cross_reference: BI:BI00686
database_cross_reference: CCPSS:1003456
database_cross_reference: CHV:0000009235
database_cross_reference: COSTAR:551
database_cross_reference: CSP:4000-0280
database_cross_reference: DO:DOID:594
database_cross_reference: DSM-5:300.01
database_cross_reference: DSM-5:F41.0
database_cross_reference: DXP:U001405
database_cross_reference: ICD10:F41.0
database_cross_reference: ICD10AM:F41.0
database_cross_reference: ICPC2P:P74007
database_cross_reference: LCH_NW:sh86006745
database_cross_reference: LNC:LA10582-7
database_cross_reference: MDR:10033666
database_cross_reference: MDR:10033667
database_cross_reference: MEDCIN:351478
database_cross_reference: MEDLINEPLUS:601
database_cross_reference: MSH:D016584
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34890
database_cross_reference: NDFRT:N0000003442
database_cross_reference: PSY:36265
database_cross_reference: RCD:Eu410
database_cross_reference: RCD:XE1Y7
database_cross_reference: RCDSY:Eu410
database_cross_reference: SNOMEDCT_US:191705007
database_cross_reference: SNOMEDCT_US:192400001
database_cross_reference: SNOMEDCT_US:268627007
database_cross_reference: SNOMEDCT_US:371631005

microglandular adenosis
type: Class
subclass of: breast disease
definition: A breast disease that is characterized by a haphazard infiltration of small, uniformly open, and round glands which are lined by a monolayer of flat to cuboidal epithelial cells that lack a myoepithelial layer, the absence of stromal desmoplasia and the presence of a thickened basement membrane.
PMOID: PMO:00033250
Subclass_of: breast disease
Synonym: Adenoses, Microglandular
Synonym: Adenosis - breast
Synonym: Adenosis of Breast
Synonym: Adenosis of the Breast
Synonym: Adenosis of the breast
Synonym: Adenosis, Microglandular
Synonym: Breast Adenosis
Synonym: Microglandular Adenoses
Synonym: Microglandular Adenosis
Synonym: adenosis
Tree Number: T10.8.9.1.3
database_cross_reference: CHV:0000015758
database_cross_reference: DO:DOID:5998
database_cross_reference: MSH:D005348
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3484
database_cross_reference: NCI_NCI-GLOSS:CDR0000637572
database_cross_reference: SNOMEDCT_US:270893004

congestive heart failure
type: Class
subclass of: heart disease
definition: A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.
PMOID: PMO:00031615
Subclass_of: heart disease
Synonym: 3-16 HEART FAILURE AND OTHER FUNCTIONAL DISORDERS
Synonym: CARDIAC FAILURE
Synonym: CARDIAC INSUFFICIENCY
Synonym: CHF
Synonym: Cardiac Failure
Synonym: Cardiac Failure Congestive
Synonym: Cardiac Insufficiency
Synonym: Cardiac failure
Synonym: Cardiac failure (NOS)
Synonym: Cardiac failure NOS
Tree Number: T10.8.3.2.2
database_cross_reference: AOD:0000005305
database_cross_reference: AOD:0000005308
database_cross_reference: BI:BI00019
database_cross_reference: CCPSS:0017571
database_cross_reference: CHV:0000005877
database_cross_reference: CHV:0000050019
database_cross_reference: COSTAR:U000338
database_cross_reference: CSP:1393-3587
database_cross_reference: CST:HEART FAIL
database_cross_reference: DO:DOID:6000
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0001635
database_cross_reference: ICD10:I50
database_cross_reference: ICD10:I50.9
database_cross_reference: ICD10AM:I50
database_cross_reference: ICD10AM:I50.9
database_cross_reference: ICD10CM:I50
database_cross_reference: ICD10CM:I50.9
database_cross_reference: ICD9CM:428
database_cross_reference: ICD9CM:428.9
database_cross_reference: ICPC2EENG:K77
database_cross_reference: ICPC2P:K29019
database_cross_reference: ICPC2P:K77004
database_cross_reference: ICPC2P:K77011
database_cross_reference: ICPC2P:K77028
database_cross_reference: LCH:U005616
database_cross_reference: LCH_NW:sh85059745
database_cross_reference: MDR:10007554
database_cross_reference: MDR:10007555
database_cross_reference: MDR:10007562
database_cross_reference: MDR:10007568
database_cross_reference: MDR:10007569
database_cross_reference: MDR:10007582
database_cross_reference: MDR:10016145
database_cross_reference: MDR:10019279
database_cross_reference: MDR:10019280
database_cross_reference: MDR:10019282
database_cross_reference: MDR:10019285
database_cross_reference: MDR:10019290
database_cross_reference: MDR:10022462
database_cross_reference: MEDCIN:95724
database_cross_reference: MEDLINEPLUS:199
database_cross_reference: MSH:D006333
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:428.9
database_cross_reference: NCI:C50577
database_cross_reference: NCI_CTCAE:E10124
database_cross_reference: NCI_FDA:2206
database_cross_reference: NCI_NICHD:C50577
database_cross_reference: OMIM:MTHU009472
database_cross_reference: OMIM:MTHU012782
database_cross_reference: OMIM:MTHU052864
database_cross_reference: RCD:G58..
database_cross_reference: RCD:XE0V9
database_cross_reference: SNM:D-7050
database_cross_reference: SNMI:D3-16000
database_cross_reference: SNOMEDCT_US:155374007
database_cross_reference: SNOMEDCT_US:155375008
database_cross_reference: SNOMEDCT_US:155377000
database_cross_reference: SNOMEDCT_US:195117009
database_cross_reference: SNOMEDCT_US:266248006
database_cross_reference: SNOMEDCT_US:266308000
database_cross_reference: SNOMEDCT_US:84114007

esophageal disease
type: Class
subclass of: gastrointestinal system disease
definition: A gastrointestinal system disease that is located_in the esophagus.
PMOID: PMO:00033438
Subclass_of: gastrointestinal system disease
Synonym: 5-30 DISEASES OF THE ESOPHAGUS
Synonym: DISEASES OF ESOPHAGUS
Synonym: DISEASES OF OESOPHAGUS
Synonym: DISEASES OF THE ESOPHAGUS
Synonym: Disease of esophagus
Synonym: Disease of esophagus (disorder)
Synonym: Disease of esophagus, NOS
Synonym: Disease of esophagus, unspecified
Synonym: Disease of oesophagus
Synonym: Disease of oesophagus, NOS
Tree Number: T10.8.11.2
database_cross_reference: AOD:0000005524
database_cross_reference: CCPSS:0031099
database_cross_reference: CCPSS:0057271
database_cross_reference: CCPSS:0057620
database_cross_reference: CHV:0000004649
database_cross_reference: CSP:1248-5440
database_cross_reference: CST:DIG/ESOPH
database_cross_reference: CST:ESOPHAGITIS
database_cross_reference: CST:GIESOPH
database_cross_reference: DO:DOID:6050
database_cross_reference: ICD10:K22.9
database_cross_reference: ICD10AM:K22.9
database_cross_reference: ICD10AMAE:K22.9
database_cross_reference: ICD10CM:K22.9
database_cross_reference: ICD9CM:530
database_cross_reference: ICD9CM:530.9
database_cross_reference: ICPC2EENG:D84
database_cross_reference: ICPC2P:D84015
database_cross_reference: LCH_NW:sh85044860
database_cross_reference: MDR:10013121
database_cross_reference: MDR:10013128
database_cross_reference: MDR:10015379
database_cross_reference: MDR:10015380
database_cross_reference: MDR:10030165
database_cross_reference: MDR:10030166
database_cross_reference: MDR:10045781
database_cross_reference: MDR:10045815
database_cross_reference: MDR:10061318
database_cross_reference: MEDCIN:90241
database_cross_reference: MEDLINEPLUS:246
database_cross_reference: MSH:D004935
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3027
database_cross_reference: NDFRT:N0000001159
database_cross_reference: RCD:J10..
database_cross_reference: RCD:J10z.
database_cross_reference: RCDAE:J10..
database_cross_reference: RCDAE:J10z.
database_cross_reference: SNM:D-6140
database_cross_reference: SNMI:D5-30000
database_cross_reference: SNOMEDCT_US:155671005
database_cross_reference: SNOMEDCT_US:155680005
database_cross_reference: SNOMEDCT_US:196626000
database_cross_reference: SNOMEDCT_US:266497000
database_cross_reference: SNOMEDCT_US:37657006

paraplegia
type: Class
subclass of: central nervous system disease
PMOID: PMO:00030171
Subclass_of: central nervous system disease
Synonym: EXTREMITY PARALYSIS, LOWER
Synonym: Hindlimb paralysis
Synonym: Leg paralysis
Synonym: Lower paraplegia
Synonym: PARAPLEGIA
Synonym: Paralysis leg
Synonym: Paralysis legs
Synonym: Paralysis of both lower limbs
Synonym: Paralysis of both lower limbs NOS
Synonym: Paralysis, Legs
Tree Number: T10.8.2.9.1
database_cross_reference: AOD:0000006230
database_cross_reference: CCPSS:1008589
database_cross_reference: CHV:0000009285
database_cross_reference: CHV:0000017409
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3658
database_cross_reference: CST:PARAPLEGIA
database_cross_reference: DO:DOID:607
database_cross_reference: DXP:U001269
database_cross_reference: DXP:U003015
database_cross_reference: HPO:HP:0010550
database_cross_reference: ICD10:G82.2
database_cross_reference: ICD10AM:G82.2
database_cross_reference: ICD10AM:G82.20
database_cross_reference: ICD10CM:G82.2
database_cross_reference: ICD10CM:G82.20
database_cross_reference: ICD9CM:344.1
database_cross_reference: ICPC2P:N99018
database_cross_reference: LCH:U003477
database_cross_reference: LCH_NW:sh85097887
database_cross_reference: LNC:LA25276-9
database_cross_reference: LNC:MTHU020806
database_cross_reference: MDR:10024131
database_cross_reference: MDR:10033814
database_cross_reference: MDR:10033892
database_cross_reference: MDR:10050045
database_cross_reference: MEDCIN:206419
database_cross_reference: MEDCIN:282990
database_cross_reference: MEDLINEPLUS:611
database_cross_reference: MSH:D010264
database_cross_reference: MTHICD9:344.1
database_cross_reference: NCI:C50687
database_cross_reference: NCI_FDA:2448
database_cross_reference: NDFRT:N0000002316
database_cross_reference: OMIM:MTHU036387
database_cross_reference: PSY:36446
database_cross_reference: RCD:F241.
database_cross_reference: SNM:F-81070
database_cross_reference: SNMI:DA-26040
database_cross_reference: SNOMEDCT_US:155031004
database_cross_reference: SNOMEDCT_US:60389000
database_cross_reference: SNOMEDCT_VET:60389000

acute stress disorder
type: Class
subclass of: anxiety disorder
PMOID: PMO:00028220
Subclass_of: anxiety disorder
Synonym: (Examination fear) or (flying phobia) or (stage fright) or (acute stress reaction NOS)
Synonym: (Examination fear) or (flying phobia) or (stage fright) or (acute stress reaction NOS) (disorder)
Synonym: 918 GROSS STRESS REACTIONS
Synonym: ACUTE STRESS DIS
Synonym: Acute Stress Disorder
Synonym: Acute Stress Disorders
Synonym: Acute crisis reaction
Synonym: Acute reaction to stress
Synonym: Acute reaction to stress, unspecified
Synonym: Acute stress disorder
Tree Number: T10.3.12.5.2
database_cross_reference: AOD:0000006840
database_cross_reference: AOD:0000024056
database_cross_reference: AOD:0000024059
database_cross_reference: CHV:0000023735
database_cross_reference: DSM-5:308.3
database_cross_reference: DSM-5:F43.0
database_cross_reference: ICD10:F43.0
database_cross_reference: ICD10AM:F43.0
database_cross_reference: ICD10CM:F43.0
database_cross_reference: ICD9CM:308
database_cross_reference: ICD9CM:308.9
database_cross_reference: ICPC2EENG:P02
database_cross_reference: ICPC2P:P02009
database_cross_reference: MDR:10001039
database_cross_reference: MDR:10001040
database_cross_reference: MDR:10001084
database_cross_reference: MDR:10001085
database_cross_reference: MDR:10045616
database_cross_reference: MEDCIN:38512
database_cross_reference: MEDCIN:98348
database_cross_reference: MSH:D040701
database_cross_reference: MTHICD9:308.3
database_cross_reference: NCI:C92621
database_cross_reference: NCI_NICHD:C92621
database_cross_reference: NDFRT:N0000011158
database_cross_reference: PSY:00733
database_cross_reference: RCD:XE1Ym
database_cross_reference: RCD:XE1Yn
database_cross_reference: SNM:F-93960
database_cross_reference: SNM:F-93990
database_cross_reference: SNMI:D9-81620
database_cross_reference: SNMI:F-91800
database_cross_reference: SNMI:F-91830
database_cross_reference: SNOMEDCT_US:154959008
database_cross_reference: SNOMEDCT_US:192036009
database_cross_reference: SNOMEDCT_US:192045005
database_cross_reference: SNOMEDCT_US:192414001
database_cross_reference: SNOMEDCT_US:268657003
database_cross_reference: SNOMEDCT_US:268791005
database_cross_reference: SNOMEDCT_US:30319004
database_cross_reference: SNOMEDCT_US:41897001
database_cross_reference: SNOMEDCT_US:67195008

primary immunodeficiency disease
type: Class
subclass of: immune system disease
definition: An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation.
PMOID: PMO:00032616
Subclass_of: immune system disease
Synonym: DEFIC SYNDROME IMMUNOL
Synonym: DEFIC SYNDROMES IMMUNOL
Synonym: Decreased immune function
Synonym: Deficiency Syndrome, Immunologic
Synonym: Deficiency Syndrome, Immunological
Synonym: Deficiency Syndromes, Immunologic
Synonym: Deficiency Syndromes, Immunological
Synonym: Deficiency;immune
Synonym: IMMUNODEFICIENCY
Synonym: IMMUNOL DEFIC SYNDROME
Tree Number: T10.8.6.1
database_cross_reference: AOD:0000004832
database_cross_reference: CCPSS:1007151
database_cross_reference: CHV:0000006602
database_cross_reference: CHV:0000049889
database_cross_reference: COSTAR:U000355
database_cross_reference: CSP:1553-9570
database_cross_reference: CSP:1560-5885
database_cross_reference: DO:DOID:612
database_cross_reference: HPO:HP:0002721
database_cross_reference: ICD10:D84.9
database_cross_reference: ICD10AM:D84.9
database_cross_reference: ICD10CM:D84.9
database_cross_reference: ICD9CM:279.3
database_cross_reference: ICPC2P:B99011
database_cross_reference: LCH_NW:sh85064574
database_cross_reference: LNC:LP231628-1
database_cross_reference: LNC:MTHU054768
database_cross_reference: MDR:10021451
database_cross_reference: MDR:10021460
database_cross_reference: MDR:10045922
database_cross_reference: MDR:10061598
database_cross_reference: MEDCIN:39922
database_cross_reference: MSH:D007153
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3131
database_cross_reference: NCI:C39725
database_cross_reference: NCI_FDA:2156
database_cross_reference: NCI_NCI-GLOSS:CDR0000045724
database_cross_reference: NCI_NCI-GLOSS:CDR0000046357
database_cross_reference: NCI_NICHD:C39725
database_cross_reference: NDFRT:N0000001667
database_cross_reference: OMIM:MTHU007447
database_cross_reference: OMIM:MTHU032911
database_cross_reference: RCD:C393.
database_cross_reference: RCD:X20GZ
database_cross_reference: SNM:D-4600
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:F-C0450
database_cross_reference: SNOMEDCT_US:191005003
database_cross_reference: SNOMEDCT_US:234532001
database_cross_reference: SNOMEDCT_US:64431000
database_cross_reference: SNOMEDCT_VET:234532001

nasal cavity carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the nasal cavity.
PMOID: PMO:00027311
Subclass_of: in situ carcinoma
Synonym: Carcinoma in situ nasal cavity
Synonym: Carcinoma in situ of Nasal Cavity
Synonym: Carcinoma in situ of nasal cavities
Synonym: Carcinoma in situ of nasal cavity
Synonym: Carcinoma in situ of nasal cavity (disorder)
Synonym: Carcinoma in situ of nasal cavity, NOS
Synonym: Carcinoma in situ of the Nasal Cavity
Synonym: Nasal Cavity Carcinoma in situ
Synonym: Stage 0 Carcinoma of Nasal Cavity
Synonym: Stage 0 Carcinoma of the Nasal Cavity
Tree Number: T10.2.2.3.26
database_cross_reference: DO:DOID:6148
database_cross_reference: ICD10CM:D02.3
database_cross_reference: MEDCIN:97317
database_cross_reference: MTHICD9:231.8
database_cross_reference: NCI:C4589
database_cross_reference: RCD:B81y1
database_cross_reference: SNMI:D2-F0112
database_cross_reference: SNOMEDCT_US:92663007

leukopenia
type: Class
subclass of: leukocyte disease
definition: A leukocyte disorder that is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.
PMOID: PMO:00033406
Subclass_of: leukocyte disease
Synonym: Decreased blood leukocyte number
Synonym: Disorder characterized by neutropenia
Synonym: LEUCOPENIA
Synonym: LEUKOPENIA
Synonym: Leucocytopenia
Synonym: Leucopenia
Synonym: Leucopenia (disorder)
Synonym: Leucopenia (finding)
Synonym: Leucopenia, NOS
Synonym: Leukocytopenia
Tree Number: T10.8.10.6.5
database_cross_reference: AOD:0000005923
database_cross_reference: BI:BI00318
database_cross_reference: CCPSS:1017211
database_cross_reference: CHV:0000007368
database_cross_reference: COSTAR:450
database_cross_reference: CSP:0427-6887
database_cross_reference: CST:LEUKOPENIA
database_cross_reference: DO:DOID:615
database_cross_reference: HPO:HP:0001882
database_cross_reference: ICD10CM:D72.819
database_cross_reference: ICD9CM:288.50
database_cross_reference: ICPC2P:B84005
database_cross_reference: MDR:10024283
database_cross_reference: MDR:10024285
database_cross_reference: MDR:10024384
database_cross_reference: MDR:10068177
database_cross_reference: MDR:10068178
database_cross_reference: MEDCIN:34856
database_cross_reference: MSH:D007970
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000175
database_cross_reference: MTHICD9:288.50
database_cross_reference: NDFRT:N0000001838
database_cross_reference: OMIM:MTHU036911
database_cross_reference: OMIM:MTHU056813
database_cross_reference: SNM:M-59100
database_cross_reference: SNMI:DC-41200
database_cross_reference: SNOMEDCT_US:142917003
database_cross_reference: SNOMEDCT_US:191348003
database_cross_reference: SNOMEDCT_US:84828003
database_cross_reference: SNOMEDCT_VET:84828003

corneal intraepithelial neoplasm
type: Class
subclass of: pre-malignant neoplasm
PMOID: PMO:00027314
Subclass_of: pre-malignant neoplasm
Synonym: CIN - corneal intraepithelial neoplasia
Synonym: Cornea Intraepithelial Neoplasia
Synonym: Corneal Intraepithelial Neoplasia
Synonym: Corneal intraepithelial neoplasia
Synonym: Corneal intraepithelial neoplasia (disorder)
Synonym: Intraepithelial Neoplasia of Cornea
Synonym: Intraepithelial Neoplasia of the Cornea
Synonym: corneal intraepithelial neoplasia (diagnosis)
Tree Number: T10.2.2.4
database_cross_reference: DO:DOID:6198
database_cross_reference: MEDCIN:355376
database_cross_reference: NCI:C6093
database_cross_reference: SNOMEDCT_US:420835009

blood protein disease
type: Class
subclass of: hematopoietic system disease
PMOID: PMO:00033322
Subclass_of: hematopoietic system disease
Synonym: BLOOD PROTEIN DIS
Synonym: Blood Protein Disorder
Synonym: Blood Protein Disorders
Synonym: Blood Protein Disorders [Disease/Finding]
Synonym: Blood protein disorders
Synonym: Disorder, Blood Protein
Synonym: Disorders, Blood Protein
Synonym: Protein Disorder, Blood
Synonym: Protein Disorders, Blood
Synonym: blood protein disorder
Tree Number: T10.8.10.2
database_cross_reference: CSP:0449-0541
database_cross_reference: DO:DOID:620
database_cross_reference: LCH:U000621
database_cross_reference: LCH_NW:sh85015013
database_cross_reference: MSH:D001796
database_cross_reference: NDFRT:N0000000578

Cronkhite-Canada syndrome
type: Class
subclass of: stomach disease
PMOID: PMO:00033453
Subclass_of: stomach disease
Synonym: CCS - Cronkhite-Canada syn
Synonym: CCS - Cronkhite-Canada syndrome
Synonym: CRONKHITE-CANADA SYNDROME
Synonym: Canada-Cronkhite syndrome
Synonym: Cronkhite-Canada Syndrome
Synonym: Cronkhite-Canada polyposis
Synonym: Cronkhite-Canada syndrome (disorder)
Synonym: Gastrointestinal multiple polyposis syndrome
Synonym: POLYPOSIS, SKIN PIGMENTATION, ALOPECIA, AND FINGERNAIL CHANGES
Synonym: Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Tree Number: T10.8.11.3.2
database_cross_reference: MDR:10062907
database_cross_reference: MEDCIN:338705
database_cross_reference: MSH:D044483
database_cross_reference: OMIM:175500
database_cross_reference: RCD:X78Og
database_cross_reference: SNM:D-6163
database_cross_reference: SNMI:D5-45500
database_cross_reference: SNOMEDCT_US:76304001

complement deficiency
type: Class
subclass of: primary immunodeficiency disease
definition: A primary immunodeficiency disease that is the result in a mutation of a gene encoding one of the thirty complement system proteins, produced predominantly in liver, which function to defend against infection and produce inflammation.
PMOID: PMO:00032683
Subclass_of: primary immunodeficiency disease
Synonym: Complement Deficiency
Synonym: Complement Deficiency Diseases
Synonym: Complement deficiency
Synonym: Complement deficiency (disorder)
Synonym: Complement deficiency disease
Synonym: Complement deficiency disease (disorder)
Synonym: Complement deficiency disease, NOS
Synonym: Defects in complement system
Synonym: Defects in the complement system
Synonym: complement deficiencies
Tree Number: T10.8.6.1.7
database_cross_reference: CHV:0000026707
database_cross_reference: CSP:1560-6347
database_cross_reference: DO:DOID:626
database_cross_reference: HPO:HP:0004431
database_cross_reference: ICD10:D84.1
database_cross_reference: ICD10AM:D84.1
database_cross_reference: ICD10CM:D80-D89
database_cross_reference: ICD10CM:D84.1
database_cross_reference: MDR:10075551
database_cross_reference: MEDCIN:333654
database_cross_reference: MEDCIN:354163
database_cross_reference: NCI:C4691
database_cross_reference: NCI_NICHD:C4691
database_cross_reference: RCD:X20Hs
database_cross_reference: SNM:D-4650
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DC-53020
database_cross_reference: SNOMEDCT_US:191014008
database_cross_reference: SNOMEDCT_US:24743004

combined T cell and B cell immunodeficiency
type: Class
subclass of: primary immunodeficiency disease
definition: A primary immunodeficiency disease that involves multiple components of the immune system, including both humoral immunity and cell-mediated immunity.
PMOID: PMO:00032621
Subclass_of: primary immunodeficiency disease
Synonym: Combined immunity defic
Synonym: Combined immunity defic. NOS
Synonym: Combined immunity deficiency
Synonym: Combined immunity deficiency NOS
Synonym: Combined immunity deficiency NOS (disorder)
Synonym: Combined immunodeficiencies
Synonym: Combined immunodeficiency
Synonym: Combined immunodeficiency syndrome
Synonym: Combined immunodeficiency, unspecified
Synonym: Congenital Combined Immunodeficiency
Tree Number: T10.8.6.1.2
database_cross_reference: CCPSS:0017291
database_cross_reference: CHV:0000037373
database_cross_reference: DO:DOID:628
database_cross_reference: HPO:HP:0005387
database_cross_reference: ICD10:D81
database_cross_reference: ICD10:D81.9
database_cross_reference: ICD10AM:D81
database_cross_reference: ICD10AM:D81.9
database_cross_reference: ICD10CM:D81
database_cross_reference: ICD10CM:D81.9
database_cross_reference: ICD9CM:279.2
database_cross_reference: MDR:10010098
database_cross_reference: MDR:10010099
database_cross_reference: MDR:10010100
database_cross_reference: MEDCIN:333590
database_cross_reference: NCI:C27871
database_cross_reference: RCD:C392z
database_cross_reference: SNOMEDCT_US:191003005

genetic disease
type: Class
subclass of: Disease
definition: A disease that has_material_basis_in genetic variations in the human genome.
PMOID: PMO:00028290
Subclass_of: Disease
Synonym: Disease, Genetic
Synonym: Disease, Hereditary
Synonym: Diseases, Genetic
Synonym: Diseases, Hereditary
Synonym: Disorder, Genetic
Synonym: Disorders, Genetic
Synonym: GENETIC DISORDER
Synonym: Genetic Condition
Synonym: Genetic Disease
Synonym: Genetic Diseases
Tree Number: T10.5
database_cross_reference: AOD:0000004904
database_cross_reference: AOD:0000004906
database_cross_reference: CCPSS:0053273
database_cross_reference: CCPSS:0056612
database_cross_reference: CHV:0000006076
database_cross_reference: CSP:1254-7727
database_cross_reference: DO:DOID:0050325
database_cross_reference: DO:DOID:630
database_cross_reference: LNC:LP56740-1
database_cross_reference: LNC:MTHU021573
database_cross_reference: LNC:MTHU025721
database_cross_reference: MDR:10019873
database_cross_reference: MDR:10061205
database_cross_reference: MEDLINEPLUS:33
database_cross_reference: MSH:D030342
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3101
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NICHD:C3101
database_cross_reference: PDQ:CDR0000043120
database_cross_reference: PSY:20830
database_cross_reference: PSY:22780
database_cross_reference: RCD:XC0dE
database_cross_reference: SNM:E-0108
database_cross_reference: SNMI:DF-00180
database_cross_reference: SNOMEDCT_US:264530000
database_cross_reference: SNOMEDCT_US:32895009

acquired immunodeficiency syndrome
type: Class
subclass of: human immunodeficiency virus infectious disease
definition: A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per ��L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.
PMOID: PMO:00029353
Subclass_of: human immunodeficiency virus infectious disease
Synonym: ACQUIRED IMMUNE DEFIC SYNDROME
Synonym: ACQUIRED IMMUNE DEFICIENCY SYNDROME
Synonym: ACQUIRED IMMUNO DEFIC SYNDROME
Synonym: ACQUIRED IMMUNODEFIC SYNDROME
Synonym: AIDS
Synonym: AIDS (disorder)
Synonym: AIDS - Acquired immunodef synd
Synonym: AIDS - Acquired immunodeficiency syndrome
Synonym: AIDS disorders
Synonym: AIDS, Acquired Immunodeficiency Syndrome
Tree Number: T10.7.2.6.1
database_cross_reference: AOD:0000000015
database_cross_reference: AOD:0000004833
database_cross_reference: AOD:0000023174
database_cross_reference: BI:BI00716
database_cross_reference: CCPSS:1014998
database_cross_reference: CHV:0000000649
database_cross_reference: COSTAR:023
database_cross_reference: CSP:1560-6271
database_cross_reference: CST:HIV SYND
database_cross_reference: DO:DOID:635
database_cross_reference: ICD10CM:B20
database_cross_reference: ICPC2P:B90001
database_cross_reference: LNC:LA10430-9
database_cross_reference: MDR:10000562
database_cross_reference: MDR:10000563
database_cross_reference: MDR:10000564
database_cross_reference: MDR:10000565
database_cross_reference: MDR:10000566
database_cross_reference: MDR:10001509
database_cross_reference: MDR:10003813
database_cross_reference: MDR:10048476
database_cross_reference: MDR:10052740
database_cross_reference: MEDCIN:31779
database_cross_reference: MEDLINEPLUS:1
database_cross_reference: MSH:D000163
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:042
database_cross_reference: NCI:C2851
database_cross_reference: NCI_FDA:1684
database_cross_reference: NCI_NCI-GLOSS:CDR0000044365
database_cross_reference: NCI_NCI-GLOSS:CDR0000045950
database_cross_reference: NCI_NICHD:C2851
database_cross_reference: NDFRT:N0000000291
database_cross_reference: PSY:00595
database_cross_reference: PSY:01515
database_cross_reference: RCD:A788z
database_cross_reference: RCD:XE0RX
database_cross_reference: SNMI:DE-36310
database_cross_reference: SNOMEDCT_US:186705005
database_cross_reference: SNOMEDCT_US:186715004
database_cross_reference: SNOMEDCT_US:234644008
database_cross_reference: SNOMEDCT_US:266201009
database_cross_reference: SNOMEDCT_US:62479008

encephalomyelitis
type: Class
subclass of: central nervous system disease
PMOID: PMO:00030480
Subclass_of: central nervous system disease
Synonym: ENCEPHALOMYELITIS
Synonym: Encephalitis &/or myelitis
Synonym: Encephalitis/myelitis
Synonym: Encephalitis/myelitis NOS
Synonym: Encephalitis/myelitis NOS (disorder)
Synonym: Encephalomyelitis
Synonym: Encephalomyelitis (disorder)
Synonym: Encephalomyelitis NOS
Synonym: Encephalomyelitis NOS (disorder)
Synonym: Encephalomyelitis [Disease/Finding]
Tree Number: T10.8.2.9.7
database_cross_reference: AOD:0000006184
database_cross_reference: CHV:0000004426
database_cross_reference: CSP:2042-4989
database_cross_reference: CST:ENCEPHALITIS
database_cross_reference: DO:DOID:640
database_cross_reference: LCH:U001573
database_cross_reference: LCH_NW:sh85042980
database_cross_reference: MDR:10014619
database_cross_reference: MEDCIN:31412
database_cross_reference: MSH:D004679
database_cross_reference: NCI:C34580
database_cross_reference: NCI_NICHD:C34580
database_cross_reference: NDFRT:N0000001085
database_cross_reference: PSY:17240
database_cross_reference: RCD:X001X
database_cross_reference: RCD:Xa3f9
database_cross_reference: RCD:XaEI5
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:DA-10130
database_cross_reference: SNOMEDCT_US:154991009
database_cross_reference: SNOMEDCT_US:192682002
database_cross_reference: SNOMEDCT_US:192735003
database_cross_reference: SNOMEDCT_US:192736002
database_cross_reference: SNOMEDCT_US:230196000
database_cross_reference: SNOMEDCT_US:267682000
database_cross_reference: SNOMEDCT_US:267684004
database_cross_reference: SNOMEDCT_US:286936006
database_cross_reference: SNOMEDCT_US:62950007
database_cross_reference: SNOMEDCT_VET:62950007

progressive multifocal leukoencephalopathy
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.
PMOID: PMO:00029420
Subclass_of: viral infectious disease
Synonym: ENCEPH JC POLYOMAVIRUS
Synonym: Encephalitis, JC Polyomavirus
Synonym: Encephalopathies, JC Polyomavirus
Synonym: Encephalopathy, JC Polyomavirus
Synonym: JC POLYOMAVIRUS ENCEPH
Synonym: JC Polyomavirus Encephalitis
Synonym: JC Polyomavirus Encephalopathy
Synonym: LEUKOENCEPH PROGRESSIVE MULTIFOCAL
Synonym: LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL
Synonym: Leukoencephalopathies, Progressive Multifocal
Tree Number: T10.7.2.54
database_cross_reference: CCPSS:1017775
database_cross_reference: CHV:0000007366
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2042-2309
database_cross_reference: DO:DOID:643
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001057
database_cross_reference: DXP:U003227
database_cross_reference: ICD10:A81.2
database_cross_reference: ICD10AM:A81.2
database_cross_reference: ICD10CM:A81.2
database_cross_reference: ICD9CM:046.3
database_cross_reference: MDR:10036806
database_cross_reference: MDR:10036807
database_cross_reference: MEDCIN:31290
database_cross_reference: MSH:D007968
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:046.3
database_cross_reference: NCI:C26815
database_cross_reference: NCI_NICHD:C26815
database_cross_reference: NDFRT:N0000001836
database_cross_reference: RCD:A413.
database_cross_reference: SNM:D-0454
database_cross_reference: SNMI:DE-32A51
database_cross_reference: SNOMEDCT_US:22255007

viral encephalitis
type: Class
subclass of: viral infectious disease
PMOID: PMO:00029401
Subclass_of: viral infectious disease
Synonym: ENCEPH INFECT VIRAL
Synonym: ENCEPH VIRAL
Synonym: Encephalitis - viral
Synonym: Encephalitis in viral dis NOS
Synonym: Encephalitis in viral disease NOS
Synonym: Encephalitis in viral disease NOS (disorder)
Synonym: Encephalitis viral
Synonym: Encephalitis viral NOS
Synonym: Encephalitis, Viral
Synonym: Encephalitis, Viral [Disease/Finding]
Tree Number: T10.7.2.44
database_cross_reference: CHV:0000025076
database_cross_reference: COSTAR:NOCODE
database_cross_reference: ICD10:A86
database_cross_reference: ICD10AM:A86
database_cross_reference: ICD10CM:A86
database_cross_reference: MDR:10014612
database_cross_reference: MDR:10014613
database_cross_reference: MDR:10047439
database_cross_reference: MEDCIN:30854
database_cross_reference: MSH:D018792
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35302
database_cross_reference: NDFRT:N0000003858
database_cross_reference: RCD:Ayu8B
database_cross_reference: RCD:F030z
database_cross_reference: RCD:Xa1eZ
database_cross_reference: RCDSY:Ayu8B
database_cross_reference: SNMI:DE-30021
database_cross_reference: SNOMEDCT_US:154321007
database_cross_reference: SNOMEDCT_US:186503001
database_cross_reference: SNOMEDCT_US:187400005
database_cross_reference: SNOMEDCT_US:192694006
database_cross_reference: SNOMEDCT_US:266190006
database_cross_reference: SNOMEDCT_US:34476008

connective tissue disease
type: Class
subclass of: musculoskeletal system disease
PMOID: PMO:00032009
Subclass_of: musculoskeletal system disease
Synonym: COLLAGEN DIS
Synonym: COLLAGEN DISEASE
Synonym: COLLAGEN DISORDER
Synonym: COLLAGEN DISORDER (NOS)
Synonym: Collagen Disease
Synonym: Collagen Diseases
Synonym: Collagen Diseases [Disease/Finding]
Synonym: Collagen Vascular Disease
Synonym: Collagen disease
Synonym: Collagen disease (disorder)
Tree Number: T10.8.4.1
database_cross_reference: CCPSS:0013328
database_cross_reference: CHV:0000003157
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0729-7550
database_cross_reference: CST:COLLAGEN DIS
database_cross_reference: DO:DOID:854
database_cross_reference: DXP:U000796
database_cross_reference: ICPC2P:L99012
database_cross_reference: LCH:U001093
database_cross_reference: LCH_NW:sh85027970
database_cross_reference: MDR:10009903
database_cross_reference: MDR:10009904
database_cross_reference: MDR:10013207
database_cross_reference: MDR:10048499
database_cross_reference: MEDCIN:38673
database_cross_reference: MSH:D003095
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:710.9
database_cross_reference: NCI:C27204
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NCI-GLOSS:CDR0000044086
database_cross_reference: NCI_NCI-GLOSS:CDR0000044127
database_cross_reference: NCI_NICHD:C27204
database_cross_reference: NDFRT:N0000000808
database_cross_reference: RCD:N00z.
database_cross_reference: SNM:D-3802
database_cross_reference: SNMI:D1-10000
database_cross_reference: SNOMEDCT_US:156458006
database_cross_reference: SNOMEDCT_US:201434000
database_cross_reference: SNOMEDCT_US:201454004
database_cross_reference: SNOMEDCT_US:268048008
database_cross_reference: SNOMEDCT_US:81573002

purine-pyrimidine metabolic disorder
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism.
PMOID: PMO:00029162
Subclass_of: inherited metabolic disorder
Synonym: O disor/purine+pyrimdn meta
Synonym: Other disorder of purine or pyrimidine metabolism NOS
Synonym: Other disorder of purine or pyrimidine metabolism NOS (disorder)
Synonym: Other disorders of purine and pyrimidine metabolism
Synonym: Other disorders of purine and pyrimidine metabolism (disorder)
Synonym: Other purine/pyrimidine disord
Synonym: Purine/pyrimid dis NEC
Synonym: Purine/pyrimidine disorder NOS
Synonym: [X]O disor/purine+pyrimdn meta
Synonym: [X]Other disorders of purine and pyrimidine metabolism
Tree Number: T10.6.2.14
database_cross_reference: DO:DOID:653
database_cross_reference: ICD10:E79.8
database_cross_reference: ICD10AM:E79.8
database_cross_reference: ICD10CM:E79.8
database_cross_reference: ICD9CM:277.2
database_cross_reference: MDR:10031998
database_cross_reference: RCD:C372z
database_cross_reference: RCD:Cyu8F
database_cross_reference: RCD:XE11m
database_cross_reference: RCDSY:Cyu8F
database_cross_reference: SNOMEDCT_US:190917005
database_cross_reference: SNOMEDCT_US:190922005
database_cross_reference: SNOMEDCT_US:191109006
database_cross_reference: SNOMEDCT_US:267450006

overnutrition
type: Class
subclass of: nutrition disease
PMOID: PMO:00028893
Subclass_of: nutrition disease
Synonym: Disorder of hyperalimentation
Synonym: Disorder of hyperalimentation (disorder)
Synonym: Hypernutrition
Synonym: Overfed
Synonym: Overnutrition
Synonym: Overnutrition [Disease/Finding]
Tree Number: T10.6.1.4.1
database_cross_reference: CHV:0000056252
database_cross_reference: DO:DOID:654
database_cross_reference: MSH:D044343
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000011007
database_cross_reference: RCD:Xa9Av
database_cross_reference: SNOMEDCT_US:302872003

inherited metabolic disorder
type: Class
subclass of: disease of metabolism
definition: A disease of metabolism that is characterized by enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality.
PMOID: PMO:00028949
Subclass_of: disease of metabolism
Synonym: Congenital Metabolic Disorder
Synonym: Congenital Metabolism Disorder
Synonym: Error, Inborn Metabolism
Synonym: Errors Metabolism, Inborn
Synonym: Errors Metabolisms, Inborn
Synonym: Errors, Inborn Metabolism
Synonym: IBEM - Inborn error of metabol
Synonym: IBEM - Inborn error of metabolism
Synonym: IEM - Inborn error metabolism
Synonym: IEM - Inborn error of metabolism
Tree Number: T10.6.2
database_cross_reference: CHV:0000008000
database_cross_reference: CSP:1849-0057
database_cross_reference: DO:DOID:655
database_cross_reference: LCH:U002925
database_cross_reference: LCH_NW:sh85084017
database_cross_reference: MDR:10021601
database_cross_reference: MDR:10021605
database_cross_reference: MDR:10062018
database_cross_reference: MSH:D008661
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34816
database_cross_reference: NCI_NICHD:C34816
database_cross_reference: NDFRT:N0000002005
database_cross_reference: RCD:X40RY
database_cross_reference: SNM:D-1001
database_cross_reference: SNMI:D6-00100
database_cross_reference: SNOMEDCT_US:363205007
database_cross_reference: SNOMEDCT_US:86095007

adenoma
type: Class
subclass of: cell type benign neoplasm
definition: A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures.
PMOID: PMO:00027425
Subclass_of: cell type benign neoplasm
Synonym: ADENOMA
Synonym: ADENOMA NOS
Synonym: ADENOMA, BENIGN
Synonym: Adenoma
Synonym: Adenoma NOS
Synonym: Adenoma [Disease/Finding]
Synonym: Adenoma benign
Synonym: Adenoma benign NOS
Synonym: Adenoma, NOS
Synonym: Adenoma, no subtype
Tree Number: T10.2.3.1.17
database_cross_reference: AOD:0000004524
database_cross_reference: CCPSS:0011787
database_cross_reference: CHV:0000000716
database_cross_reference: COSTAR:027
database_cross_reference: CSP:2000-1015
database_cross_reference: CST:ADENOMA
database_cross_reference: DO:DOID:657
database_cross_reference: ICD10AM:M8140/0
database_cross_reference: LCH:U000067
database_cross_reference: LCH_NW:sh85000843
database_cross_reference: LNC:LA15390-0
database_cross_reference: MDR:10001231
database_cross_reference: MDR:10001233
database_cross_reference: MDR:10001234
database_cross_reference: MDR:10001236
database_cross_reference: MEDLINEPLUS:3585
database_cross_reference: MSH:D000236
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2855
database_cross_reference: NCI_CDISC:C2855
database_cross_reference: NCI_NCI-GLOSS:CDR0000046217
database_cross_reference: NDFRT:N0000000310
database_cross_reference: RCD:BB50.
database_cross_reference: RCD:Xa98K
database_cross_reference: RCDSY:BB50.
database_cross_reference: SNM:M-8140/0
database_cross_reference: SNMI:M-81400
database_cross_reference: SNOMEDCT_US:189578007
database_cross_reference: SNOMEDCT_US:189579004
database_cross_reference: SNOMEDCT_US:32048006
database_cross_reference: SNOMEDCT_US:443416007

muscle tissue disease
type: Class
subclass of: muscular disease
definition: A muscular disease in which the muscle fibers do not function resulting in muscular weakness.
PMOID: PMO:00032322
Subclass_of: muscular disease
Synonym: A-51 MYOPATHIES
Synonym: DISORDER MUSCLE
Synonym: Disorder muscle
Synonym: Disorder of muscle
Synonym: Disorder of muscle (disorder)
Synonym: Disorder of muscle -RETIRED-
Synonym: Disorder of muscle, NOS
Synonym: Disorder of muscle, unspec
Synonym: Disorder of muscle, unspecified
Synonym: Disorder of skeletal AND/OR smooth muscle
Tree Number: T10.8.4.3.1
database_cross_reference: AOD:0000005063
database_cross_reference: AOD:0000005066
database_cross_reference: BI:BI00507
database_cross_reference: CCPSS:0045912
database_cross_reference: CCPSS:1018022
database_cross_reference: CHV:0000008361
database_cross_reference: COSTAR:U000457
database_cross_reference: CSP:1982-9451
database_cross_reference: CST:MS/MUS
database_cross_reference: CST:MYOPATHY
database_cross_reference: DO:DOID:0080000
database_cross_reference: DO:DOID:423
database_cross_reference: DO:DOID:66
database_cross_reference: DXP:U002703
database_cross_reference: HPO:HP:0003198
database_cross_reference: ICD10:G72.9
database_cross_reference: ICD10:M60-M63.9
database_cross_reference: ICD10:M62.9
database_cross_reference: ICD10AM:G72.9
database_cross_reference: ICD10AM:M60-M63.9
database_cross_reference: ICD10AM:M62.9
database_cross_reference: ICD10CM:G72.9
database_cross_reference: ICD10CM:M60-M63
database_cross_reference: ICD10CM:M62.9
database_cross_reference: ICD9CM:359.9
database_cross_reference: ICPC2P:L99023
database_cross_reference: LCH_NW:sh85088688
database_cross_reference: MDR:10013237
database_cross_reference: MDR:10028300
database_cross_reference: MDR:10028301
database_cross_reference: MDR:10028302
database_cross_reference: MDR:10028640
database_cross_reference: MDR:10028641
database_cross_reference: MDR:10028649
database_cross_reference: MEDCIN:319450
database_cross_reference: MEDCIN:91077
database_cross_reference: MEDLINEPLUS:510
database_cross_reference: MSH:D009135
database_cross_reference: MTH:503
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101216
database_cross_reference: NCI_NICHD:C101216
database_cross_reference: NDFRT:N0000002064
database_cross_reference: OMIM:590030
database_cross_reference: OMIM:590075
database_cross_reference: OMIM:MTHU003653
database_cross_reference: OMIM:MTHU049021
database_cross_reference: PSY:32600
database_cross_reference: RCD:Nyu8B
database_cross_reference: RCD:X708D
database_cross_reference: RCD:X708s
database_cross_reference: RCDSY:Nyu8B
database_cross_reference: SNM:D-8004
database_cross_reference: SNM:D-8060
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D1-50010
database_cross_reference: SNMI:DA-51000
database_cross_reference: SNOMEDCT_US:129565002
database_cross_reference: SNOMEDCT_US:155094005
database_cross_reference: SNOMEDCT_US:155099000
database_cross_reference: SNOMEDCT_US:203833006
database_cross_reference: SNOMEDCT_US:203845002
database_cross_reference: SNOMEDCT_US:267711006
database_cross_reference: SNOMEDCT_US:267714003

diffuse infiltrative lymphocytosis syndrome
type: Class
subclass of: syndrome
definition: A syndrome that occurs in human immunodeficiency virus (HIV) positive patients, which is accompanied by decreased kidney function. The spectrum of kidney involvement includes acute or chronic kidney disease, primarily tubular proteinuria and dense lymphocytic tubulointerstitial infiltrates predominantly composed of CD8 T cells.
PMOID: PMO:00025246
Subclass_of: syndrome
Synonym: DILS - diffuse infiltrative lymphocytosis syndrome
Synonym: Diffuse Infiltrative Lymphocytosis Syndrome
Synonym: Diffuse infiltra. lymph. sydrome
Synonym: Diffuse infiltrative lymphocytosis syndrome
Synonym: Diffuse infiltrative lymphocytosis syndrome (disorder)
Tree Number: T10.1.106
database_cross_reference: DO:DOID:6677
database_cross_reference: NCI:C35699
database_cross_reference: NCI_CTEP-SDC:10025280
database_cross_reference: SNOMEDCT_US:449784008

tooth and nail syndrome
type: Class
subclass of: syndrome
definition: A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.
PMOID: PMO:00025200
Subclass_of: syndrome
Synonym: Dysplasia of nails with hypodontia
Synonym: ECTD3
Synonym: ECTODERMAL DYSPLASIA 3, TOOTH/NAIL TYPE
Synonym: ECTODERMAL DYSPLASIA 3, WITKOP TYPE
Synonym: HND
Synonym: Hypodontia and Nail Dysplasia
Synonym: Hypodontia with Nail Dysplasia
Synonym: Hypodontia-Nail Dysplasia
Synonym: Hypoplastic enamel-onycholysis-hypohidrosis syndrome
Synonym: Hypoplastic enamel-onycholysis-hypohidrosis syndrome (disorder)
Tree Number: T10.1.78
database_cross_reference: DO:DOID:6678
database_cross_reference: MSH:C536736
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C40553
database_cross_reference: OMIM:142983
database_cross_reference: OMIM:189500
database_cross_reference: RCD:X50Hp
database_cross_reference: SNM:M-74480
database_cross_reference: SNMI:D4-40142
database_cross_reference: SNOMEDCT_US:239039003
database_cross_reference: SNOMEDCT_US:400036004
database_cross_reference: SNOMEDCT_US:68897000

Achard syndrome
type: Class
subclass of: syndrome
definition: A syndrome that involves arachnodactyly, receding lower jaw, and joint laxity limited to the hands and feet.
PMOID: PMO:00025249
Subclass_of: syndrome
Synonym: ACHARD SYNDROME
Synonym: Achard Syndrome
Synonym: Arachnodactyly, receding lower jaw, and joint laxity limited to the hands and feet
Synonym: Dysostoses and increased ligament laxity
Tree Number: T10.1.109
database_cross_reference: DO:DOID:6686
database_cross_reference: MSH:C536012
database_cross_reference: NCI:C35809
database_cross_reference: OMIM:100700

Achenbach syndrome
type: Class
subclass of: skin disease
PMOID: PMO:00033787
Subclass_of: skin disease
Synonym: Achenbach Syndrome
Synonym: Achenbach's syndrome
Synonym: Paroxys haematoma of finger
Synonym: Paroxys hematoma of finger
Synonym: Paroxysmal haematoma of the finger
Synonym: Paroxysmal hematoma of the finger
Synonym: Paroxysmal hematoma of the finger (disorder)
Tree Number: T10.8.12.2.3
database_cross_reference: DO:DOID:6687
database_cross_reference: NCI:C35467
database_cross_reference: RCD:X50CN
database_cross_reference: RCDAE:X50CN
database_cross_reference: SNOMEDCT_US:238824006

Aagenaes syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.
PMOID: PMO:00025156
Subclass_of: syndrome
Synonym: AAGENAES SYNDROME
Synonym: Aagenaes Syndrome
Synonym: CHLS
Synonym: CHOLESTASIS-LYMPHEDEMA SYNDROME
Synonym: Cholestasis lymphedema syndrome
Synonym: Cholestasis-Lymphedema Syndrome
Synonym: Cholestasis-edema syndrome, Norwegian type
Synonym: Cholestasis-edema syndrome, Norwegian type (disorder)
Synonym: Cholestasis-lymphedema syndrome
Synonym: Cholestasis-lymphoedema syndrome
Tree Number: T10.1.37
database_cross_reference: CHV:0000026294
database_cross_reference: DO:DOID:6691
database_cross_reference: MSH:C535330
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35709
database_cross_reference: OMIM:214900
database_cross_reference: SNMI:D6-85650
database_cross_reference: SNOMEDCT_US:28724005

Barre-Lieou syndrome
type: Class
subclass of: syndrome
definition: A syndrome that involves occipital head aches, nystagmus on head movement, tinnitus, spasms, blurred vision, corneal hyperaesthesia, and corneal ulcers.
PMOID: PMO:00025170
Subclass_of: syndrome
Synonym: Barre Lieou Syndrome
Synonym: Barre-Lieou Syndrome
Synonym: Barre-Lieou syndrome (diagnosis)
Synonym: Barré-Liéou syndrome
Synonym: Cervicocranial syndrome
Synonym: Neri-Barre syndrome
Synonym: Post cervical sympathetic synd
Synonym: Posterior Cervical Sympathetic Syndrome
Synonym: Posterior Cervical Sympathetic Syndrome [Disease/Finding]
Synonym: Posterior cervical sympathetic syndrome
Tree Number: T10.1.51
database_cross_reference: CHV:0000031757
database_cross_reference: DO:DOID:6692
database_cross_reference: ICD10CM:M53.0
database_cross_reference: MDR:10042744
database_cross_reference: MDR:10068282
database_cross_reference: MEDCIN:34441
database_cross_reference: MSH:D055010
database_cross_reference: MTHICD9:723.2
database_cross_reference: NCI:C34411
database_cross_reference: NDFRT:N0000181136
database_cross_reference: RCD:N132.
database_cross_reference: SNM:D-3056
database_cross_reference: SNMI:D1-23664
database_cross_reference: SNOMEDCT_US:17300000

amphetamine abuse
type: Class
subclass of: substance abuse
PMOID: PMO:00027917
Subclass_of: substance abuse
Synonym: Abuse, Amphetamine
Synonym: Abuse;drug(s);amphetamine
Synonym: Amfetamine abuse
Synonym: Amphetamine Abuse
Synonym: Amphetamine abuse
Synonym: Amphetamine abuse (disorder)
Synonym: DRUG ABUSE AMPHETAMINE
Synonym: Drug abuse using speed
Synonym: abuse amphetamine
Synonym: abuse amphetamines
Tree Number: T10.3.3.2.5
database_cross_reference: BI:BI00683
database_cross_reference: CCPSS:0052114
database_cross_reference: CHV:0000023734
database_cross_reference: ICPC2P:P19019
database_cross_reference: LCH_NW:sh85004593
database_cross_reference: MDR:10068729
database_cross_reference: MEDCIN:32702
database_cross_reference: MSH:D019969
database_cross_reference: RCD:Xa2m3
database_cross_reference: SNMI:D9-30200
database_cross_reference: SNOMEDCT_US:84758004

cleft palate
type: Class
subclass of: orofacial cleft
definition: An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate.
PMOID: PMO:00028285
Subclass_of: orofacial cleft
Synonym: (Palatoschisis) or (unspecified cleft palate)
Synonym: (Palatoschisis) or (unspecified cleft palate) (disorder)
Synonym: CLEFT PALATE
Synonym: CP - Cleft palate
Synonym: Cleft Palate
Synonym: Cleft Palate [Disease/Finding]
Synonym: Cleft Palates
Synonym: Cleft palate
Synonym: Cleft palate (disorder)
Synonym: Cleft palate NOS
Tree Number: T10.4.21.1
database_cross_reference: AOD:0000004973
database_cross_reference: CCPSS:0045791
database_cross_reference: CHV:0000003027
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0725-9049
database_cross_reference: CST:CLEFT PALATE
database_cross_reference: DO:DOID:674
database_cross_reference: DXP:U000774
database_cross_reference: HPO:HP:0000175
database_cross_reference: ICD10:Q35
database_cross_reference: ICD10:Q35.9
database_cross_reference: ICD10AM:Q35
database_cross_reference: ICD10AM:Q35.9
database_cross_reference: ICD10CM:Q35
database_cross_reference: ICD10CM:Q35.9
database_cross_reference: ICD9CM:749.0
database_cross_reference: ICD9CM:749.00
database_cross_reference: LCH:U001048
database_cross_reference: LCH_NW:sh85026926
database_cross_reference: LNC:LA14412-3
database_cross_reference: MDR:10009269
database_cross_reference: MDR:10009283
database_cross_reference: MDR:10033529
database_cross_reference: MDR:10068904
database_cross_reference: MEDCIN:30403
database_cross_reference: MEDLINEPLUS:191
database_cross_reference: MSH:D002972
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87069
database_cross_reference: NCI_CDISC:C87069
database_cross_reference: NCI_NICHD:C87069
database_cross_reference: NDFRT:N0000000793
database_cross_reference: OMIM:MTHU000511
database_cross_reference: OMIM:MTHU042142
database_cross_reference: PSY:09480
database_cross_reference: RCD:P90..
database_cross_reference: RCD:P90z.
database_cross_reference: RCD:X788H
database_cross_reference: RCD:XE1Kc
database_cross_reference: SNMI:D4-51300
database_cross_reference: SNOMEDCT_US:156940009
database_cross_reference: SNOMEDCT_US:204593009
database_cross_reference: SNOMEDCT_US:204605001
database_cross_reference: SNOMEDCT_US:253986002
database_cross_reference: SNOMEDCT_US:268196005
database_cross_reference: SNOMEDCT_US:87979003

peroneal nerve paralysis
type: Class
subclass of: peripheral nervous system disease
PMOID: PMO:00029891
Subclass_of: peripheral nervous system disease
Synonym: Nerve Palsy, Peroneal
Synonym: Nerve Paralyses, Peroneal
Synonym: Nerve Paralysis, Peroneal
Synonym: PALSY PERONEAL
Synonym: PARALYSIS PERONEAL
Synonym: PERONEAL NERVE PALSY
Synonym: Palsy peroneal
Synonym: Palsy, Peroneal Nerve
Synonym: Paralyses, Peroneal Nerve
Synonym: Paralysis peroneal
Tree Number: T10.8.2.4.2
database_cross_reference: CCPSS:0049552
database_cross_reference: CHV:0000026531
database_cross_reference: CST:FOOT DROP
database_cross_reference: DO:DOID:6925
database_cross_reference: ICD10CM:G57.3
database_cross_reference: MDR:10033563
database_cross_reference: MDR:10033828
database_cross_reference: MDR:10034701
database_cross_reference: MSH:D020427
database_cross_reference: NCI:C27061
database_cross_reference: NCI_FDA:2362
database_cross_reference: SNMI:DA-26604
database_cross_reference: SNOMEDCT_US:34553007

disease of anatomical entity
type: Class
subclass of: Disease
definition: A disease that manifests in a defined anatomical structure.
PMOID: PMO:00029731
Subclass_of: Disease
Tree Number: T10.8
database_cross_reference: DO:DOID:7

mitochondrial metabolism disease
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that involves mitochondrial metabolism dysfunction.
PMOID: PMO:00028950
Subclass_of: inherited metabolic disorder
Synonym: Disease, Mitochondrial
Synonym: Disorder, Mitochondrial
Synonym: Disorders, Mitochondrial
Synonym: MITOCHONDRIAL DIS
Synonym: Mitochondrial Disease
Synonym: Mitochondrial Diseases
Synonym: Mitochondrial Diseases [Disease/Finding]
Synonym: Mitochondrial Disorder
Synonym: Mitochondrial Disorders
Synonym: Mitochondrial disease
Tree Number: T10.6.2.1
database_cross_reference: CHV:0000048471
database_cross_reference: CSP:5000-0048
database_cross_reference: DO:DOID:0080013
database_cross_reference: DO:DOID:700
database_cross_reference: MEDLINEPLUS:6391
database_cross_reference: MSH:D028361
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000010931
database_cross_reference: SNOMEDCT_US:240096000

anisakiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.
PMOID: PMO:00029641
Subclass_of: parasitic helminthiasis infectious disease
Synonym: EOSINOPHILIC GASTROENTERITIS
Synonym: Eosinophilic Gastroenteritis
Synonym: Eosinophilic gastroent
Synonym: Eosinophilic gastroenteritis
Synonym: Eosinophilic gastroenteritis (disorder)
Synonym: Eosinophilic gastroenteropathy
Synonym: Eosinophilic gastroenteropathy (disorder)
Synonym: Eosinophilic gastroenteropathy, NOS
Synonym: Gastroenteritis eosinophilic
Synonym: Infection by Anisakis larva
Tree Number: T10.7.4.1.19
database_cross_reference: CHV:0000056559
database_cross_reference: CSP:1248-5821
database_cross_reference: DO:DOID:4031
database_cross_reference: DO:DOID:7033
database_cross_reference: DXP:U000570
database_cross_reference: ICD9CM:558.41
database_cross_reference: MDR:10017902
database_cross_reference: MEDCIN:313225
database_cross_reference: MSH:C535952
database_cross_reference: NCI:C35330
database_cross_reference: SNMI:D5-00350
database_cross_reference: SNMI:DE-67900
database_cross_reference: SNOMEDCT_US:32183007
database_cross_reference: SNOMEDCT_US:359804008
database_cross_reference: SNOMEDCT_US:68270003

thyroiditis
type: Class
subclass of: thyroid gland disease
PMOID: PMO:00033183
Subclass_of: thyroid gland disease
Synonym: THYROIDITIS
Synonym: Thyroid gland inflammation
Synonym: Thyroiditides
Synonym: Thyroiditis
Synonym: Thyroiditis (disorder)
Synonym: Thyroiditis NOS
Synonym: Thyroiditis NOS (disorder)
Synonym: Thyroiditis [Disease/Finding]
Synonym: Thyroiditis, NOS
Synonym: Thyroiditis, unspecified
Tree Number: T10.8.8.3.7
database_cross_reference: AOD:0000005982
database_cross_reference: BI:BI00360
database_cross_reference: CCPSS:0058105
database_cross_reference: CHV:0000012269
database_cross_reference: COSTAR:735
database_cross_reference: CSP:2928-7350
database_cross_reference: CST:THYROIDITIS
database_cross_reference: DO:DOID:7166
database_cross_reference: DXP:U004022
database_cross_reference: HPO:HP:0100646
database_cross_reference: ICD10:E06
database_cross_reference: ICD10:E06.9
database_cross_reference: ICD10AM:E06
database_cross_reference: ICD10AM:E06.9
database_cross_reference: ICD10CM:E06
database_cross_reference: ICD10CM:E06.9
database_cross_reference: ICD9CM:245
database_cross_reference: ICD9CM:245.9
database_cross_reference: ICPC2P:T99041
database_cross_reference: LCH:U004688
database_cross_reference: LCH_NW:sh85135177
database_cross_reference: MDR:10043778
database_cross_reference: MDR:10043783
database_cross_reference: MDR:10043785
database_cross_reference: MEDCIN:30538
database_cross_reference: MSH:D013966
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:245.9
database_cross_reference: NCI:C26894
database_cross_reference: NCI_NCI-GLOSS:CDR0000455472
database_cross_reference: NCI_NICHD:C26894
database_cross_reference: NDFRT:N0000002944
database_cross_reference: OMIM:MTHU036938
database_cross_reference: RCD:C05..
database_cross_reference: RCD:C05z.
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:DB-80600
database_cross_reference: SNOMEDCT_US:154664009
database_cross_reference: SNOMEDCT_US:154668007
database_cross_reference: SNOMEDCT_US:190301009
database_cross_reference: SNOMEDCT_US:82119001

normocytic anemia
type: Class
subclass of: anemia
PMOID: PMO:00033373
Subclass_of: anemia
Synonym: ANAEMIA NORMOCYTIC
Synonym: ANEMIA NORMOCYTIC
Synonym: Anaemia normocytic
Synonym: Anemia normocytic
Synonym: NORMOCYTIC ANEMIA
Synonym: Normocytic Anemia
Synonym: Normocytic anaemia
Synonym: Normocytic anemia
Synonym: Normocytic anemia (disorder)
Synonym: anemia normocytic
Tree Number: T10.8.10.4.8
database_cross_reference: AOD:0000005877
database_cross_reference: BI:BI00293
database_cross_reference: CCPSS:0061959
database_cross_reference: CHV:0000015664
database_cross_reference: CST:ANEMIA NORMOCYT
database_cross_reference: DO:DOID:720
database_cross_reference: HPO:HP:0001897
database_cross_reference: MDR:10002070
database_cross_reference: MDR:10002302
database_cross_reference: MDR:10029784
database_cross_reference: MDR:10029785
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35142
database_cross_reference: OMIM:MTHU039167
database_cross_reference: RCD:Xa7n0
database_cross_reference: RCDAE:Xa7n0
database_cross_reference: SNM:D-4017
database_cross_reference: SNOMEDCT_US:300980002

female stress incontinence
type: Class
subclass of: bladder disease
PMOID: PMO:00033090
Subclass_of: bladder disease
Synonym: Fem stress incontinence
Synonym: Female Stress Incontinence
Synonym: Female stress incontinence
Synonym: Female urinary stress incontinence
Synonym: Female urinary stress incontinence (finding)
Synonym: Stress incontinence - female
Synonym: Stress incontinence - female (finding)
Synonym: Stress incontinence, female
Synonym: female incontinence stress
Synonym: female stress incontinence (diagnosis)
Tree Number: T10.8.7.11.3
database_cross_reference: CHV:0000011772
database_cross_reference: DO:DOID:724
database_cross_reference: ICD9CM:625.6
database_cross_reference: MDR:10042214
database_cross_reference: MEDCIN:34243
database_cross_reference: NCI:C35042
database_cross_reference: RCD:K586.
database_cross_reference: SNMI:F-72062
database_cross_reference: SNOMEDCT_US:156028007
database_cross_reference: SNOMEDCT_US:198408003
database_cross_reference: SNOMEDCT_US:266668007
database_cross_reference: SNOMEDCT_US:60241006

premenstrual tension
type: Class
subclass of: female reproductive system disease
PMOID: PMO:00029806
Subclass_of: female reproductive system disease
Synonym: PMT
Synonym: PMT - Premenstrual tension
Synonym: PREMENSTRUAL TENSION
Synonym: Premenstrual Tension
Synonym: Premenstrual Tensions
Synonym: Premenstrual tension
Synonym: Premenstrual tension (disorder)
Synonym: Premenstrual tension -RETIRED-
Synonym: Premenstrual tension NOS
Synonym: Premenstrual tension syndrom
Tree Number: T10.8.1.4.5
database_cross_reference: CHV:0000031749
database_cross_reference: COSTAR:610
database_cross_reference: CSP:1138-6312
database_cross_reference: DO:DOID:727
database_cross_reference: DXP:U001580
database_cross_reference: DXP:U003219
database_cross_reference: ICD10:N94.3
database_cross_reference: ICD10AM:N94.3
database_cross_reference: ICD10CM:N94.3
database_cross_reference: ICD9CM:625.4
database_cross_reference: ICPC2EENG:X89
database_cross_reference: ICPC2P:X89001
database_cross_reference: MDR:10035635
database_cross_reference: MDR:10036619
database_cross_reference: MDR:10036620
database_cross_reference: MSH:D011293
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:625.4
database_cross_reference: PSY:40130
database_cross_reference: RCD:XE0el
database_cross_reference: SNM:D-2431
database_cross_reference: SNM:F-30320
database_cross_reference: SNMI:D7-76000
database_cross_reference: SNOMEDCT_US:123076003
database_cross_reference: SNOMEDCT_US:156026006
database_cross_reference: SNOMEDCT_US:198407008
database_cross_reference: SNOMEDCT_US:82639001

urinary system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
definition: An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.
PMOID: PMO:00027584
Subclass_of: organ system benign neoplasm
Synonym: NEOPL UROL
Synonym: Neoplasm of Urinary System
Synonym: Neoplasm of Urinary Tract
Synonym: Neoplasm of the Urinary System
Synonym: Neoplasm of the Urinary Tract
Synonym: Neoplasm of urinary system
Synonym: Neoplasm of urinary system (disorder)
Synonym: Neoplasm of urinary tract
Synonym: Neoplasm of urinary tract (disorder)
Synonym: Neoplasm of urinary tract proper
Tree Number: T10.2.3.2.7
database_cross_reference: AOD:0000023077
database_cross_reference: CHV:0000012807
database_cross_reference: CSP:2021-0179
database_cross_reference: DO:DOID:731
database_cross_reference: HPO:HP:0010786
database_cross_reference: ICPC2P:U79002
database_cross_reference: MDR:10046583
database_cross_reference: MDR:10061398
database_cross_reference: MSH:D014571
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3431
database_cross_reference: NDFRT:N0000003087
database_cross_reference: RCD:X78Ys
database_cross_reference: RCDAE:X78Ys
database_cross_reference: SNOMEDCT_US:126879004
database_cross_reference: SNOMEDCT_US:254913005

urethral disease
type: Class
subclass of: urinary system disease
definition: A urinary system disease that is located_in the urethra.
PMOID: PMO:00032959
Subclass_of: urinary system disease
Synonym: 7-23 DISEASES OF THE URETHRA
Synonym: DISEASES OF THE URETHRA
Synonym: Disease of urethra
Synonym: Disease of urethra (disorder)
Synonym: Disease of urethra, NOS
Synonym: Disease, Urethral
Synonym: Diseases, Urethral
Synonym: Disorder of urethra
Synonym: Disorder of urethra (disorder)
Synonym: Disorder of urethra, NOS
Tree Number: T10.8.7.3
database_cross_reference: CHV:0000012766
database_cross_reference: CSP:3045-8915
database_cross_reference: CST:UG/UT/UTA
database_cross_reference: CST:URIN TRACT DIS
database_cross_reference: DO:DOID:732
database_cross_reference: ICD10:N36.9
database_cross_reference: ICD10AM:N36.9
database_cross_reference: ICD10CM:N36.9
database_cross_reference: LCH_NW:sh85141387
database_cross_reference: MDR:10046445
database_cross_reference: MDR:10046446
database_cross_reference: MEDCIN:95371
database_cross_reference: MEDLINEPLUS:5352
database_cross_reference: MSH:D014522
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26903
database_cross_reference: NDFRT:N0000003072
database_cross_reference: RCD:Kyu5F
database_cross_reference: RCD:X30Ou
database_cross_reference: RCDSY:Kyu5F
database_cross_reference: SNM:D-6815
database_cross_reference: SNMI:D7-23000
database_cross_reference: SNOMEDCT_US:197945001
database_cross_reference: SNOMEDCT_US:198551002
database_cross_reference: SNOMEDCT_US:4985009

Kimura disease
type: Class
subclass of: skin disease
PMOID: PMO:00033984
Subclass_of: skin disease
Synonym: Disease, Kimura
Synonym: Eosinophilic Granuloma of Soft Tissue
Synonym: Eosinophilic Hyperplastic Lymphogranuloma
Synonym: Eosinophilic Hyperplastic Lymphogranulomas
Synonym: Eosinophilic Lymphofollicular Granuloma
Synonym: Eosinophilic Lymphofollicular Granulomas
Synonym: Eosinophilic Lymphofolliculoses
Synonym: Eosinophilic Lymphofolliculosis
Synonym: Granuloma, Eosinophilic Lymphofollicular
Synonym: Granulomas, Eosinophilic Lymphofollicular
Tree Number: T10.8.12.2.48
database_cross_reference: CHV:0000010303
database_cross_reference: DO:DOID:7365
database_cross_reference: DXP:NOCODE
database_cross_reference: MDR:10048640
database_cross_reference: MSH:D000796
database_cross_reference: NCI:C26867
database_cross_reference: RCD:X78Uh
database_cross_reference: SNMI:DC-72210
database_cross_reference: SNOMEDCT_US:254791004
database_cross_reference: SNOMEDCT_US:399894006
database_cross_reference: SNOMEDCT_US:69484003

pituitary hypoplasia
type: Class
subclass of: pituitary gland disease
PMOID: PMO:00033223
Subclass_of: pituitary gland disease
Synonym: Hypoplasia of the pituitary gland
Synonym: Pituitary Gland Hypoplasia
Synonym: Pituitary Hypoplasia
Synonym: Pituitary gland hypoplasia
Synonym: Pituitary hypoplasia
Synonym: hypoplasia pituitary
Tree Number: T10.8.8.5.4
database_cross_reference: CHV:0000053316
database_cross_reference: DO:DOID:7378
database_cross_reference: HPO:HP:0010627
database_cross_reference: MDR:10051944
database_cross_reference: NCI:C27343
database_cross_reference: OMIM:MTHU025078
database_cross_reference: OMIM:MTHU034851

hematopoietic system disease
type: Class
subclass of: disease of anatomical entity
definition: An immune system disease that has_material_basis_in hematopoietic cells.
PMOID: PMO:00033258
Subclass_of: disease of anatomical entity
Synonym: BLOOD DIS
Synonym: BLOOD DYSCRASIA
Synonym: Blood Disease
Synonym: Blood Diseases
Synonym: Blood Disorder
Synonym: Blood Disorders
Synonym: Blood Dyscrasia
Synonym: Blood disease
Synonym: Blood disease NOS
Synonym: Blood diseases
Tree Number: T10.8.10
database_cross_reference: AOD:0000005866
database_cross_reference: AOD:0000005867
database_cross_reference: CCPSS:0029030
database_cross_reference: CHV:0000005950
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000029
database_cross_reference: COSTAR:U000340
database_cross_reference: CSP:0427-3600
database_cross_reference: CSP:0430-5619
database_cross_reference: CST:BLOOD DYSCRASIA
database_cross_reference: CST:HEM
database_cross_reference: DO:DOID:74
database_cross_reference: HPO:HP:0001871
database_cross_reference: ICD10:D75.9
database_cross_reference: ICD10AM:D75.9
database_cross_reference: ICD10CM:D75.9
database_cross_reference: ICD9CM:280-289.99
database_cross_reference: ICD9CM:289.9
database_cross_reference: ICPC2P:B99021
database_cross_reference: LCH_NW:sh85014939
database_cross_reference: LNC:LA17777-6
database_cross_reference: MDR:10005493
database_cross_reference: MDR:10005495
database_cross_reference: MDR:10005496
database_cross_reference: MDR:10013120
database_cross_reference: MDR:10013192
database_cross_reference: MDR:10013227
database_cross_reference: MDR:10013895
database_cross_reference: MDR:10018847
database_cross_reference: MDR:10019426
database_cross_reference: MDR:10045763
database_cross_reference: MDR:10061590
database_cross_reference: MEDCIN:38675
database_cross_reference: MEDCIN:39952
database_cross_reference: MEDLINEPLUS:3646
database_cross_reference: MSH:D006402
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:289.9
database_cross_reference: NCI:C26323
database_cross_reference: NCI_NICHD:C26323
database_cross_reference: NDFRT:N0000001459
database_cross_reference: PSY:06260
database_cross_reference: PSY:22630
database_cross_reference: RCD:D....
database_cross_reference: RCD:D41z.
database_cross_reference: RCD:XE14Q
database_cross_reference: RCD:XE158
database_cross_reference: SNM:D-4000
database_cross_reference: SNM:D-4001
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DC-00000
database_cross_reference: SNOMEDCT_US:154785002
database_cross_reference: SNOMEDCT_US:154842002
database_cross_reference: SNOMEDCT_US:191124002
database_cross_reference: SNOMEDCT_US:191402006
database_cross_reference: SNOMEDCT_US:191446003
database_cross_reference: SNOMEDCT_US:267552000
database_cross_reference: SNOMEDCT_US:267573000
database_cross_reference: SNOMEDCT_US:34093004

anthrax disease
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.
PMOID: PMO:00029511
Subclass_of: primary bacterial infectious disease
Synonym: ANTHRAX
Synonym: Anthrax
Synonym: Anthrax (disorder)
Synonym: Anthrax NOS
Synonym: Anthrax NOS (disorder)
Synonym: Anthrax [Disease/Finding]
Synonym: Anthrax disease
Synonym: Anthrax, NOS
Synonym: Anthrax, unspecified
Synonym: Bacillus anthracis infection
Tree Number: T10.7.3.1.17
database_cross_reference: CHV:0000001246
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0368-2534
database_cross_reference: DO:DOID:7427
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000128
database_cross_reference: ICD10:A22
database_cross_reference: ICD10:A22.9
database_cross_reference: ICD10AM:A22
database_cross_reference: ICD10AM:A22.9
database_cross_reference: ICD10CM:A22
database_cross_reference: ICD10CM:A22.9
database_cross_reference: ICD9CM:022
database_cross_reference: ICD9CM:022.9
database_cross_reference: ICPC2P:A78002
database_cross_reference: LCH:U000275
database_cross_reference: LCH_NW:sh85005563
database_cross_reference: LNC:LA10432-5
database_cross_reference: MDR:10002713
database_cross_reference: MDR:10002716
database_cross_reference: MDR:10003975
database_cross_reference: MEDCIN:30927
database_cross_reference: MEDLINEPLUS:1565
database_cross_reference: MSH:D000881
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84565
database_cross_reference: NCI_NICHD:C84565
database_cross_reference: NDFRT:N0000000429
database_cross_reference: RCD:A22..
database_cross_reference: RCD:A22z.
database_cross_reference: RCD:Ayu25
database_cross_reference: RCDSY:Ayu25
database_cross_reference: SNM:D-0113
database_cross_reference: SNMI:DE-11200
database_cross_reference: SNOMEDCT_US:154295005
database_cross_reference: SNOMEDCT_US:17540007
database_cross_reference: SNOMEDCT_US:186304006
database_cross_reference: SNOMEDCT_US:187302001
database_cross_reference: SNOMEDCT_US:409498004

hypogonadotropism
type: Class
subclass of: gonadal disease
definition: A gonadal disease that is characterized by diminished functional activity of the gonads.
PMOID: PMO:00033114
Subclass_of: gonadal disease
Synonym: Decreased activity of gonads
Synonym: HYPOGONADISM
Synonym: Hypogonadism
Synonym: Hypogonadism (disorder)
Synonym: Hypogonadism [Disease/Finding]
Synonym: Hypogonadism, NOS
Synonym: Hypogonadotropism
Synonym: hypogonadism
Synonym: hypogonadism (diagnosis)
Tree Number: T10.8.8.2.1
database_cross_reference: AOD:0000005865
database_cross_reference: CCPSS:1013140
database_cross_reference: CHV:0000006477
database_cross_reference: CHV:0000052805
database_cross_reference: COSTAR:U000373
database_cross_reference: CSP:2586-8835
database_cross_reference: DO:DOID:1924
database_cross_reference: DO:DOID:7455
database_cross_reference: DXP:U002049
database_cross_reference: HPO:HP:0000135
database_cross_reference: ICPC2P:T99032
database_cross_reference: LCH:U002330
database_cross_reference: LCH_NW:sh85063790
database_cross_reference: MDR:10058359
database_cross_reference: MEDCIN:30700
database_cross_reference: MSH:D007006
database_cross_reference: NCI:C9227
database_cross_reference: NDFRT:N0000001636
database_cross_reference: OMIM:MTHU000132
database_cross_reference: PSY:24000
database_cross_reference: RCD:X40Ov
database_cross_reference: SNMI:DB-12702
database_cross_reference: SNOMEDCT_US:48130008

enterobiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching.
PMOID: PMO:00029677
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection with Oxyuris
Synonym: Infection with Oxyuris (disorder)
Synonym: OXYURIASIS
Synonym: Oxyuriases
Synonym: Oxyuriasis
Synonym: Oxyuriasis [Disease/Finding]
Synonym: Oxyuris vermicularis infection
Synonym: Threadworm infection
Synonym: oxyuriasis
Tree Number: T10.7.4.1.42
database_cross_reference: DO:DOID:7457
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:B80
database_cross_reference: ICPC2P:D22005
database_cross_reference: ICPC2P:D96006
database_cross_reference: LCH:U003432
database_cross_reference: LCH_NW:sh85096357
database_cross_reference: MDR:10062569
database_cross_reference: MEDLINEPLUS:3065
database_cross_reference: MSH:D010123
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:127.4
database_cross_reference: NDFRT:N0000002275
database_cross_reference: RCD:XE0SZ
database_cross_reference: SNM:D-0689
database_cross_reference: SNMI:DE-68500
database_cross_reference: SNOMEDCT_US:154415009
database_cross_reference: SNOMEDCT_US:187178006
database_cross_reference: SNOMEDCT_US:19722001
database_cross_reference: SNOMEDCT_US:266162007
database_cross_reference: SNOMEDCT_US:266222003
database_cross_reference: SNOMEDCT_VET:319421000009108

diverticulitis
type: Class
subclass of: intestinal disease
definition: An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall.
PMOID: PMO:00033628
Subclass_of: intestinal disease
Synonym: DIVERTICULITIS
Synonym: Diverticulitides
Synonym: Diverticulitis
Synonym: Diverticulitis (disorder)
Synonym: Diverticulitis (morphologic abnormality)
Synonym: Diverticulitis NOS
Synonym: Diverticulitis NOS (disorder)
Synonym: Diverticulitis [Disease/Finding]
Synonym: Diverticulitis unspecified
Synonym: Diverticulitis unspecified (disorder)
Tree Number: T10.8.11.8.30
database_cross_reference: BI:BI00234
database_cross_reference: CHV:0000004051
database_cross_reference: COSTAR:247
database_cross_reference: CST:COLITIS
database_cross_reference: DO:DOID:7475
database_cross_reference: DXP:U000488
database_cross_reference: DXP:U000984
database_cross_reference: LCH:U001438
database_cross_reference: LCH_NW:sh85038581
database_cross_reference: MDR:10013538
database_cross_reference: MDR:10013543
database_cross_reference: MEDLINEPLUS:214
database_cross_reference: MSH:D004238
database_cross_reference: MTH:246
database_cross_reference: MTHICD9:562.11
database_cross_reference: NCI:C26752
database_cross_reference: NCI_NCI-GLOSS:CDR0000630901
database_cross_reference: NDFRT:N0000000988
database_cross_reference: OMIM:MTHU026283
database_cross_reference: RCD:J511y
database_cross_reference: RCD:J511z
database_cross_reference: RCD:XaB8Z
database_cross_reference: SNM:M-46420
database_cross_reference: SNMI:M-40630
database_cross_reference: SNOMEDCT_US:155779000
database_cross_reference: SNOMEDCT_US:18126004
database_cross_reference: SNOMEDCT_US:197095003
database_cross_reference: SNOMEDCT_US:197102009
database_cross_reference: SNOMEDCT_US:197103004
database_cross_reference: SNOMEDCT_US:307496006

active peptic ulcer disease
type: Class
subclass of: peptic ulcer disease
PMOID: PMO:00033435
Subclass_of: peptic ulcer disease
Synonym: active peptic ulcer disease/GI bleeding
Tree Number: T10.8.11.1.5
database_cross_reference: DO:DOID:749
database_cross_reference: PDQ:CDR0000038918

lymphatic system disease
type: Class
subclass of: immune system disease
definition: An immune system disease that is located_in the lymphatic system.
PMOID: PMO:00032912
Subclass_of: immune system disease
Synonym: Adenopathy
Synonym: DISEASES OF THE LYMPHOID TISSUES
Synonym: Disease of lymphoid system
Synonym: Disease of lymphoid system (disorder)
Synonym: Disease, Lymphatic
Synonym: Diseases of lymph node or lymph vessels
Synonym: Diseases, Lymphatic
Synonym: Disord of lymph node+lymphat
Synonym: Disorder of lymphatic system
Synonym: Disorder of lymphatic system (disorder)
Tree Number: T10.8.6.4
database_cross_reference: AOD:0000005957
database_cross_reference: CHV:0000007601
database_cross_reference: CHV:0000057225
database_cross_reference: CSP:0427-7757
database_cross_reference: CST:HAL/LYM
database_cross_reference: DO:DOID:75
database_cross_reference: HPO:HP:0100763
database_cross_reference: LCH_NW:sh85079135
database_cross_reference: MDR:10025221
database_cross_reference: MDR:10025222
database_cross_reference: MDR:10052314
database_cross_reference: MDR:10061231
database_cross_reference: MEDCIN:360603
database_cross_reference: MEDLINEPLUS:591
database_cross_reference: MSH:D008206
database_cross_reference: MTH:461
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001898
database_cross_reference: PSY:29040
database_cross_reference: RCD:X206Z
database_cross_reference: SNM:D-7430
database_cross_reference: SNMI:D3-A0000
database_cross_reference: SNMI:DC-70000
database_cross_reference: SNOMEDCT_US:111590001
database_cross_reference: SNOMEDCT_US:155452000
database_cross_reference: SNOMEDCT_US:234087005
database_cross_reference: SNOMEDCT_US:266326002
database_cross_reference: SNOMEDCT_US:3305006
database_cross_reference: SNOMEDCT_US:362971004

peptic ulcer disease
type: Class
subclass of: gastrointestinal system disease
PMOID: PMO:00033430
Subclass_of: gastrointestinal system disease
Synonym: GDU
Synonym: Gastroduodenal Ulcer
Synonym: Gastroduodenal Ulcers
Synonym: Gastroduodenal ulcer
Synonym: Gastroduodenal ulcer, NOS
Synonym: PEPTIC ULCER
Synonym: PEPTIC ULCER DISEASE
Synonym: PEPTIC ULCER SYNDROME
Synonym: PU - Peptic ulcer
Synonym: PUD
Tree Number: T10.8.11.1
database_cross_reference: AOD:0000005551
database_cross_reference: BI:BI00030
database_cross_reference: BI:BI00248
database_cross_reference: CCPSS:1018146
database_cross_reference: CHV:0000009452
database_cross_reference: COSTAR:572
database_cross_reference: COSTAR:573
database_cross_reference: CSP:1248-6649
database_cross_reference: CST:PEPTIC ULCER SYND
database_cross_reference: CST:ULCER PEPTIC
database_cross_reference: DO:DOID:750
database_cross_reference: DXP:U003067
database_cross_reference: HPO:HP:0004398
database_cross_reference: ICD10:K27
database_cross_reference: ICD10AM:K27
database_cross_reference: ICD10CM:K27
database_cross_reference: ICD9CM:533
database_cross_reference: ICPC2P:D86002
database_cross_reference: LCH:U003533
database_cross_reference: LCH_NW:sh85099682
database_cross_reference: MDR:10017886
database_cross_reference: MDR:10018053
database_cross_reference: MDR:10034341
database_cross_reference: MDR:10034343
database_cross_reference: MDR:10034360
database_cross_reference: MDR:10034367
database_cross_reference: MDR:10034369
database_cross_reference: MDR:10037287
database_cross_reference: MDR:10042834
database_cross_reference: MDR:10045305
database_cross_reference: MDR:10045328
database_cross_reference: MDR:10045342
database_cross_reference: MEDCIN:30221
database_cross_reference: MEDLINEPLUS:357
database_cross_reference: MSH:D010437
database_cross_reference: MTH:572
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3318
database_cross_reference: NCI_NCI-GLOSS:CDR0000650040
database_cross_reference: NCI_NICHD:C3318
database_cross_reference: NDFRT:N0000002351
database_cross_reference: PSY:37320
database_cross_reference: RCD:J13y.
database_cross_reference: RCD:J13yz
database_cross_reference: RCD:J13z.
database_cross_reference: RCD:XE0aR
database_cross_reference: RCD:XM0BZ
database_cross_reference: SNM:D-6001
database_cross_reference: SNM:M-38090
database_cross_reference: SNMI:D5-34300
database_cross_reference: SNOMEDCT_US:13200003
database_cross_reference: SNOMEDCT_US:155701001
database_cross_reference: SNOMEDCT_US:155710009
database_cross_reference: SNOMEDCT_US:196681007
database_cross_reference: SNOMEDCT_US:196697002
database_cross_reference: SNOMEDCT_US:196704007
database_cross_reference: SNOMEDCT_US:196705008
database_cross_reference: SNOMEDCT_US:266437002
database_cross_reference: SNOMEDCT_US:266501005

inhibited female orgasm
type: Class
subclass of: female reproductive system disease
PMOID: PMO:00029827
Subclass_of: female reproductive system disease
Synonym: Female Orgasmic Disorder
Synonym: Female orgasmic disorder
Synonym: Inhibited female orgasm
Synonym: Inhibited female orgasm (disorder)
Synonym: Inhibited female orgasm, psychogenic
Synonym: disorder female orgasmic
Synonym: female Orgasmic disorder
Synonym: female orgasmic disorder
Synonym: female orgasmic disorder (diagnosis)
Tree Number: T10.8.1.4.10
database_cross_reference: AOD:0000006819
database_cross_reference: CHV:0000010340
database_cross_reference: DO:DOID:7518
database_cross_reference: DSM-5:302.73
database_cross_reference: DSM-5:F52.31
database_cross_reference: HPO:HP:0030015
database_cross_reference: ICD10CM:F52.31
database_cross_reference: ICD9CM:302.73
database_cross_reference: MDR:10016405
database_cross_reference: MDR:10022032
database_cross_reference: MEDCIN:32823
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34958
database_cross_reference: RCD:E2274
database_cross_reference: SNMI:D9-73531
database_cross_reference: SNOMEDCT_US:191794003
database_cross_reference: SNOMEDCT_US:60103007

peptic ulcer perforation
type: Class
subclass of: peptic ulcer disease
PMOID: PMO:00033431
Subclass_of: peptic ulcer disease
Synonym: PEPTIC ULCER PERFORATED
Synonym: PERFORATED PEPTIC ULCER
Synonym: Peptic Ulcer Perforation
Synonym: Peptic Ulcer Perforation [Disease/Finding]
Synonym: Peptic Ulcer Perforations
Synonym: Peptic ulcer perforated
Synonym: Peptic ulcer perforation
Synonym: Peptic ulcer with perforation
Synonym: Peptic ulcer with perforation (disorder)
Synonym: Peptic ulcer, NOS with perforation
Tree Number: T10.8.11.1.1
database_cross_reference: CHV:0000009454
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:ULCER PEPTIC PER
database_cross_reference: DO:DOID:752
database_cross_reference: LCH:U003534
database_cross_reference: LCH_NW:sh85099687
database_cross_reference: MDR:10034353
database_cross_reference: MDR:10034354
database_cross_reference: MDR:10034371
database_cross_reference: MDR:10034396
database_cross_reference: MDR:10045332
database_cross_reference: MSH:D010439
database_cross_reference: NDFRT:N0000002353
database_cross_reference: RCD:J13y2
database_cross_reference: RCD:XM0sI
database_cross_reference: SNMI:D5-34380
database_cross_reference: SNOMEDCT_US:155703003
database_cross_reference: SNOMEDCT_US:196700003
database_cross_reference: SNOMEDCT_US:266502003
database_cross_reference: SNOMEDCT_US:88169003

gonorrhea
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.
PMOID: PMO:00029575
Subclass_of: primary bacterial infectious disease
Synonym: CLAP
Synonym: Clap
Synonym: E-120 GONORRHEA
Synonym: GC
Synonym: GC - Gonococcus infection
Synonym: GCI - Gonococcal infection
Synonym: GONOCOCCAL
Synonym: GONOCOCCAL INFECTION
Synonym: GONORRHEA
Synonym: Gonococcal
Tree Number: T10.7.3.1.31
database_cross_reference: AOD:0000004855
database_cross_reference: BI:BI00442
database_cross_reference: CCPSS:0030291
database_cross_reference: CCPSS:0045056
database_cross_reference: CCPSS:0050241
database_cross_reference: CHV:0000005660
database_cross_reference: CHV:0000037834
database_cross_reference: COSTAR:334
database_cross_reference: CSP:0368-2885
database_cross_reference: DO:DOID:7551
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001723
database_cross_reference: ICD10:A54
database_cross_reference: ICD10:A54.9
database_cross_reference: ICD10AM:A54
database_cross_reference: ICD10AM:A54.9
database_cross_reference: ICD10CM:A54
database_cross_reference: ICD10CM:A54.9
database_cross_reference: ICD9CM:098
database_cross_reference: LCH:U002027
database_cross_reference: LCH_NW:sh85055863
database_cross_reference: LNC:LA10467-1
database_cross_reference: MDR:10018584
database_cross_reference: MDR:10018604
database_cross_reference: MDR:10018612
database_cross_reference: MDR:10018615
database_cross_reference: MEDCIN:97578
database_cross_reference: MEDLINEPLUS:3019
database_cross_reference: MSH:D006069
database_cross_reference: MTH:U001967
database_cross_reference: MTHICD9:098.0
database_cross_reference: NCI:C35730
database_cross_reference: NCI:C92950
database_cross_reference: NCI_NICHD:C92950
database_cross_reference: NDFRT:N0000001380
database_cross_reference: PSY:21330
database_cross_reference: RCD:A98..
database_cross_reference: RCD:Ayu4C
database_cross_reference: RCD:XE0S0
database_cross_reference: RCDAE:A98..
database_cross_reference: RCDSY:Ayu4C
database_cross_reference: SNM:D-0131
database_cross_reference: SNMI:DE-12000
database_cross_reference: SNMI:L-22201
database_cross_reference: SNOMEDCT_US:154387008
database_cross_reference: SNOMEDCT_US:15628003
database_cross_reference: SNOMEDCT_US:186943001
database_cross_reference: SNOMEDCT_US:187361005
database_cross_reference: SNOMEDCT_US:266142004

situs inversus
type: Class
subclass of: visceral heterotaxy
PMOID: PMO:00028281
Subclass_of: visceral heterotaxy
Synonym: Abdominal situs inversus
Synonym: Complete transposition
Synonym: Complete transposition (morphologic abnormality)
Synonym: Inversus, Situs
Synonym: Laterality sequence
Synonym: SITUS INVERSUS
Synonym: SITUS INVERSUS VISCERUM
Synonym: SIV
Synonym: Situs Ambiguus
Synonym: Situs Inversus
Tree Number: T10.4.18.2
database_cross_reference: CCPSS:1003480
database_cross_reference: CHV:0000011378
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:758
database_cross_reference: HPO:HP:0001696
database_cross_reference: HPO:HP:0003363
database_cross_reference: ICD10:Q89.3
database_cross_reference: ICD10AM:Q89.3
database_cross_reference: ICD10CM:Q89.3
database_cross_reference: ICD9CM:759.3
database_cross_reference: JABL:341
database_cross_reference: MDR:10040761
database_cross_reference: MEDCIN:30430
database_cross_reference: MSH:D012857
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87121
database_cross_reference: NCI_CDISC:C87121
database_cross_reference: NCI_NICHD:C87121
database_cross_reference: NDFRT:N0000002757
database_cross_reference: OMIM:270100
database_cross_reference: OMIM:MTHU001474
database_cross_reference: OMIM:MTHU007549
database_cross_reference: RCD:PK3..
database_cross_reference: RCD:PK3z.
database_cross_reference: RCD:X78EZ
database_cross_reference: SNM:M-22110
database_cross_reference: SNM:M-24210
database_cross_reference: SNMI:D4-D0100
database_cross_reference: SNMI:M-22111
database_cross_reference: SNOMEDCT_US:157025003
database_cross_reference: SNOMEDCT_US:157033002
database_cross_reference: SNOMEDCT_US:205765000
database_cross_reference: SNOMEDCT_US:205770007
database_cross_reference: SNOMEDCT_US:254257004
database_cross_reference: SNOMEDCT_US:268359006
database_cross_reference: SNOMEDCT_US:27317008
database_cross_reference: SNOMEDCT_US:43876007

stomach disease
type: Class
subclass of: gastrointestinal system disease
definition: A gastrointestinal system disease that is located_in the stomach.
PMOID: PMO:00033451
Subclass_of: gastrointestinal system disease
Synonym: 5-32-33 DISEASES OF THE STOMACH
Synonym: DISEASES OF THE STOMACH
Synonym: Disease of stomach
Synonym: Disease of stomach (disorder)
Synonym: Disease of stomach, NOS
Synonym: Disease, Gastric
Synonym: Disease, Stomach
Synonym: Diseases, Gastric
Synonym: Diseases, Stomach
Synonym: Disorder of stomach
Tree Number: T10.8.11.3
database_cross_reference: AOD:0000005588
database_cross_reference: CCPSS:0046368
database_cross_reference: CHV:0000011740
database_cross_reference: CSP:1248-7189
database_cross_reference: CST:DIG/STOM
database_cross_reference: DO:DOID:76
database_cross_reference: LCH_NW:sh85128261
database_cross_reference: MDR:10056819
database_cross_reference: MDR:10072971
database_cross_reference: MEDCIN:312834
database_cross_reference: MEDLINEPLUS:420
database_cross_reference: MSH:D013272
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26886
database_cross_reference: NDFRT:N0000002826
database_cross_reference: RCD:X301D
database_cross_reference: RCD:X301N
database_cross_reference: SNM:D-6160
database_cross_reference: SNMI:D5-32000
database_cross_reference: SNOMEDCT_US:155671005
database_cross_reference: SNOMEDCT_US:183927002
database_cross_reference: SNOMEDCT_US:196598004
database_cross_reference: SNOMEDCT_US:266497000
database_cross_reference: SNOMEDCT_US:29384001

gastrointestinal system disease
type: Class
subclass of: disease of anatomical entity
definition: A disease of anatomical entity that is located_in the gastrointestinal tract.
PMOID: PMO:00033429
Subclass_of: disease of anatomical entity
Synonym: CHAPTER 5 DISEASES OF THE DIGESTIVE SYSTEM
Synonym: DIGESTIVE SYSTEM DIS
Synonym: DISEASES OF THE DIGESTIVE SYSTEM
Synonym: DISEASES OF THE DIGESTIVE SYSTEM: GENERAL CONDITIONS
Synonym: Digestive Diseases
Synonym: Digestive System Disease
Synonym: Digestive System Diseases
Synonym: Digestive System Diseases [Disease/Finding]
Synonym: Digestive System Disorders
Synonym: Digestive syst. disease
Tree Number: T10.8.11
database_cross_reference: AOD:0000005499
database_cross_reference: CHV:0000003939
database_cross_reference: CSP:4000-0163
database_cross_reference: DO:DOID:77
database_cross_reference: HPO:HP:0011024
database_cross_reference: ICD10:K00-K93.9
database_cross_reference: ICD10:K92.9
database_cross_reference: ICD10AM:K00-K93.9
database_cross_reference: ICD10AM:K92.9
database_cross_reference: ICD10CM:K92.9
database_cross_reference: ICD9CM:520-579.99
database_cross_reference: MEDCIN:334823
database_cross_reference: MEDLINEPLUS:29
database_cross_reference: MSH:D004066
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000973
database_cross_reference: PSY:14230
database_cross_reference: RCD:J....
database_cross_reference: RCD:Jz...
database_cross_reference: SNM:D-6000
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D5-00000
database_cross_reference: SNOMEDCT_US:155629009
database_cross_reference: SNOMEDCT_US:155847001
database_cross_reference: SNOMEDCT_US:197575000
database_cross_reference: SNOMEDCT_US:266483008
database_cross_reference: SNOMEDCT_US:53619000

delusional disorder
type: Class
subclass of: psychotic disorder
definition: A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.
PMOID: PMO:00028166
Subclass_of: psychotic disorder
Synonym: 9-71 DELUSIONAL DISORDERS
Synonym: DELUSIONAL DIS
Synonym: DELUSIONAL DISORDER
Synonym: DELUSIONAL DISORDERS
Synonym: Delusional Disorder
Synonym: Delusional Disorders
Synonym: Delusional disorder
Synonym: Delusional disorder (disorder)
Synonym: Delusional disorder, NOS
Synonym: Delusional disorders
Tree Number: T10.3.12.1.1
database_cross_reference: CCPSS:0058799
database_cross_reference: CHV:0000003680
database_cross_reference: DO:DOID:778
database_cross_reference: DSM-5:297.1
database_cross_reference: DSM-5:F22
database_cross_reference: ICD10:F22.0
database_cross_reference: ICD10AM:F22.0
database_cross_reference: ICD10CM:F22
database_cross_reference: ICD9CM:297.1
database_cross_reference: MDR:10012256
database_cross_reference: MEDCIN:33796
database_cross_reference: MSH:D012563
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:297
database_cross_reference: NCI:C94379
database_cross_reference: RCD:XE1ZO
database_cross_reference: SNMI:D9-71000
database_cross_reference: SNOMEDCT_US:192330005
database_cross_reference: SNOMEDCT_US:48500005

renal infectious disease
type: Class
subclass of: kidney disease
PMOID: PMO:00033025
Subclass_of: kidney disease
Synonym: Infection - kidney
Synonym: Infection of kidney
Synonym: Infection of kidney NOS
Synonym: Infection of kidney NOS (disorder)
Synonym: Infection of kidney, unspecified
Synonym: Infection;kidney
Synonym: Infections of kidney
Synonym: Infectious disorder of kidney
Synonym: Infectious disorder of kidney (disorder)
Synonym: KIDNEY INFECTION
Tree Number: T10.8.7.9.9
database_cross_reference: CHV:0000006692
database_cross_reference: CSP:3046-0132
database_cross_reference: DO:DOID:782
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10CM:N15.9
database_cross_reference: ICD9CM:590
database_cross_reference: ICD9CM:590.9
database_cross_reference: ICPC2P:U70001
database_cross_reference: MDR:10021850
database_cross_reference: MDR:10021851
database_cross_reference: MDR:10021895
database_cross_reference: MDR:10023424
database_cross_reference: MDR:10023429
database_cross_reference: MEDCIN:98697
database_cross_reference: MEDLINEPLUS:448
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:K10..
database_cross_reference: RCD:K10z.
database_cross_reference: SNOMEDCT_US:129128006
database_cross_reference: SNOMEDCT_US:155865002
database_cross_reference: SNOMEDCT_US:197785002
database_cross_reference: SNOMEDCT_US:266618004

laryngeal disease
type: Class
subclass of: upper respiratory tract disease
PMOID: PMO:00032491
Subclass_of: upper respiratory tract disease
Synonym: 2-04 DISEASES OF THE LARYNX
Synonym: DISEASES OF THE LARYNX
Synonym: Disease of larynx
Synonym: Disease of larynx NOS
Synonym: Disease of larynx unspecified
Synonym: Disease of larynx unspecified (disorder)
Synonym: Disease of the larynx
Synonym: Disease of the larynx (disorder)
Synonym: Disease of the larynx, NOS
Synonym: Disease or syndrome of larynx
Tree Number: T10.8.5.2.8
database_cross_reference: CHV:0000007219
database_cross_reference: CSP:2596-4086
database_cross_reference: CST:RES/LRNX
database_cross_reference: DO:DOID:786
database_cross_reference: ICD10CM:J38.7
database_cross_reference: ICD10CM:S12.8
database_cross_reference: ICD9CM:478.70
database_cross_reference: LCH_NW:sh85074747
database_cross_reference: MDR:10023837
database_cross_reference: MDR:10045749
database_cross_reference: MDR:10061263
database_cross_reference: MEDCIN:210343
database_cross_reference: MSH:D007818
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26810
database_cross_reference: NDFRT:N0000001782
database_cross_reference: PSY:27790
database_cross_reference: RCD:H1y70
database_cross_reference: RCD:XM0Am
database_cross_reference: SNM:D-X750
database_cross_reference: SNMI:D2-04000
database_cross_reference: SNOMEDCT_US:195863001
database_cross_reference: SNOMEDCT_US:60600009

mite infestation
type: Class
subclass of: parasitic ectoparasitic infectious disease
definition: A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae.
PMOID: PMO:00029726
Subclass_of: parasitic ectoparasitic infectious disease
Synonym: (Scabies) or (acariasis)
Synonym: (Scabies) or (acariasis) (disorder)
Synonym: Infestation by Sarcoptes scabiei
Synonym: Infestation by Sarcoptes scabiei var hominis
Synonym: Sarcoptic itch
Synonym: scabies
Tree Number: T10.7.4.4.5
database_cross_reference: DO:DOID:7894
database_cross_reference: DO:DOID:8295
database_cross_reference: SNOMEDCT_US:154422001
database_cross_reference: SNOMEDCT_US:266224002

thyrotoxicosis
type: Class
subclass of: thyroid gland disease
definition: A thyroid gland disease that is characterized by excess thyroid hormone.
PMOID: PMO:00033167
Subclass_of: thyroid gland disease
Synonym: THYROTOXICOSIS
Synonym: Thyrotoxicoses
Synonym: Thyrotoxicosis
Synonym: Thyrotoxicosis (disorder)
Synonym: Thyrotoxicosis +/- goiter
Synonym: Thyrotoxicosis +/- goitre
Synonym: Thyrotoxicosis NOS
Synonym: Thyrotoxicosis NOS (disorder)
Synonym: Thyrotoxicosis [Ambiguous]
Synonym: Thyrotoxicosis [Disease/Finding]
Tree Number: T10.8.8.3.4
database_cross_reference: AOD:0000005991
database_cross_reference: BI:BI00016
database_cross_reference: CCPSS:1013284
database_cross_reference: CHV:0000012271
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:HYPERTHYR
database_cross_reference: DO:DOID:7997
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:E05.9
database_cross_reference: ICD10AM:E05.9
database_cross_reference: ICD10CM:E05.9
database_cross_reference: ICD9CM:242
database_cross_reference: ICPC2P:T85008
database_cross_reference: MDR:10043789
database_cross_reference: MDR:10043798
database_cross_reference: MDR:10043799
database_cross_reference: MEDCIN:37894
database_cross_reference: MEDLINEPLUS:6177
database_cross_reference: MSH:D013971
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:242.9
database_cross_reference: NCI:C61469
database_cross_reference: NCI_NICHD:C61469
database_cross_reference: NDFRT:N0000002948
database_cross_reference: OMIM:275000
database_cross_reference: PSY:53150
database_cross_reference: RCD:C02zz
database_cross_reference: RCD:XE104
database_cross_reference: RCD:Xa3eb
database_cross_reference: RCDAE:Xa3eb
database_cross_reference: SNM:D-2192
database_cross_reference: SNMI:DB-80204
database_cross_reference: SNOMEDCT_US:154655004
database_cross_reference: SNOMEDCT_US:154659005
database_cross_reference: SNOMEDCT_US:190239004
database_cross_reference: SNOMEDCT_US:190267008
database_cross_reference: SNOMEDCT_US:267373004
database_cross_reference: SNOMEDCT_US:267464006
database_cross_reference: SNOMEDCT_US:286909009
database_cross_reference: SNOMEDCT_US:90739004

hyperthyroidism
type: Class
subclass of: thyroid gland disease
definition: A thyroid gland disease that involves an over production of thyroid hormone.
PMOID: PMO:00033189
Subclass_of: thyroid gland disease
Synonym: HYPERTHYROID
Synonym: HYPERTHYROIDISM
Synonym: Hyperthyroid
Synonym: Hyperthyroidism
Synonym: Hyperthyroidism (disorder)
Synonym: Hyperthyroidism NOS
Synonym: Hyperthyroidism [Disease/Finding]
Synonym: Hyperthyroidism, NOS
Synonym: Hyperthyroids
Synonym: Overactive Thyroid
Tree Number: T10.8.8.3.8
database_cross_reference: AOD:0000005987
database_cross_reference: BI:BI00016
database_cross_reference: CCPSS:0058114
database_cross_reference: CHV:0000006451
database_cross_reference: CHV:0000047722
database_cross_reference: COSTAR:398
database_cross_reference: CSP:2928-6789
database_cross_reference: CST:HYPERTHYR
database_cross_reference: DO:DOID:7998
database_cross_reference: DXP:U000889
database_cross_reference: DXP:U002036
database_cross_reference: HPO:HP:0000836
database_cross_reference: ICD10CM:E05.9
database_cross_reference: ICPC2P:T85007
database_cross_reference: LCH:U002318
database_cross_reference: LCH_NW:sh85063728
database_cross_reference: LNC:MTHU020782
database_cross_reference: MDR:10020850
database_cross_reference: MEDCIN:30532
database_cross_reference: MEDLINEPLUS:6177
database_cross_reference: MSH:D006980
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:242.9
database_cross_reference: NCI:C3123
database_cross_reference: NCI_CTCAE:E10322
database_cross_reference: NCI_NCI-GLOSS:CDR0000044524
database_cross_reference: NCI_NCI-GLOSS:CDR0000045717
database_cross_reference: NCI_NICHD:C3123
database_cross_reference: NDFRT:N0000001622
database_cross_reference: OMIM:MTHU001214
database_cross_reference: PDQ:CDR0000489293
database_cross_reference: PSY:23850
database_cross_reference: RCD:XE104
database_cross_reference: SNM:D-2190
database_cross_reference: SNMI:DB-80200
database_cross_reference: SNOMEDCT_US:154655004
database_cross_reference: SNOMEDCT_US:190239004
database_cross_reference: SNOMEDCT_US:267464006
database_cross_reference: SNOMEDCT_US:34486009
database_cross_reference: SNOMEDCT_VET:34486009

cocaine abuse
type: Class
subclass of: substance abuse
definition: A substance abuse that involves the recurring use of cocaine despite negative consequences.
PMOID: PMO:00027919
Subclass_of: substance abuse
Synonym: Abuse, Cocaine
Synonym: Abuse;drug(s);cocaine
Synonym: COCAINE ABUSE
Synonym: Cocaine Abuse
Synonym: Cocaine abuse
Synonym: Cocaine abuse (disorder)
Synonym: Cocaine abuse, unspecified
Synonym: Cocaine abuse, unspecified use
Synonym: Cocaine abuse-unspec
Synonym: abuse cocaine
Tree Number: T10.3.3.2.7
database_cross_reference: BI:BI00675
database_cross_reference: CCPSS:1017304
database_cross_reference: CHV:0000003098
database_cross_reference: DO:DOID:809
database_cross_reference: ICD10CM:F14.1
database_cross_reference: ICD9CM:305.6
database_cross_reference: ICD9CM:305.60
database_cross_reference: ICPC2P:P19023
database_cross_reference: LCH_NW:sh85027560
database_cross_reference: MDR:10009810
database_cross_reference: MDR:10009814
database_cross_reference: MEDCIN:32701
database_cross_reference: MSH:D019970
database_cross_reference: MTHICD9:305.60
database_cross_reference: SNMI:D9-30400
database_cross_reference: SNOMEDCT_US:78267003

fibroepithelial polyp of urethra
type: Class
subclass of: urethral disease
PMOID: PMO:00032961
Subclass_of: urethral disease
Synonym: Fibroepithelial Polyp of Urethra
Synonym: Fibroepithelial Polyp of the Urethra
Synonym: Urethra Fibroepithelial Polyp
Synonym: Urethral Fibroepithelial Polyp
Synonym: urethral Fibroepithelial polyp
Tree Number: T10.8.7.3.2
database_cross_reference: DO:DOID:8108
database_cross_reference: NCI:C6170

lipodystrophy
type: Class
subclass of: connective tissue disease
definition: A connective tissue disease that is characterized by marked reduction, absence, and/or the redistribution of adipose tissue.
PMOID: PMO:00032287
Subclass_of: connective tissue disease
Synonym: CUTANEOUS LIPODYSTROPHY
Synonym: Dystrophy of fatty tissue
Synonym: Dystrophy, fatty tissue
Synonym: LIPODYSTROPHY
Synonym: Lipodystrophies
Synonym: Lipodystrophy
Synonym: Lipodystrophy (disorder)
Synonym: Lipodystrophy NOS
Synonym: Lipodystrophy NOS (disorder)
Synonym: Lipodystrophy [Disease/Finding]
Tree Number: T10.8.4.1.12
database_cross_reference: AOD:0000005730
database_cross_reference: CHV:0000007457
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000169
database_cross_reference: CSP:1745-6360
database_cross_reference: CST:LIPODYSTROPHY
database_cross_reference: DO:DOID:811
database_cross_reference: HPO:HP:0009125
database_cross_reference: ICD10CM:E88.1
database_cross_reference: ICD9CM:272.6
database_cross_reference: ICPC2P:T93017
database_cross_reference: ICPC2P:T99075
database_cross_reference: MDR:10024606
database_cross_reference: MDR:10024608
database_cross_reference: MEDCIN:338592
database_cross_reference: MSH:D008060
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C97093
database_cross_reference: NDFRT:N0000001850
database_cross_reference: OMIM:MTHU037286
database_cross_reference: RCD:C326z
database_cross_reference: RCD:XE11X
database_cross_reference: SNM:M-56020
database_cross_reference: SNMI:DB-61700
database_cross_reference: SNOMEDCT_US:190789006
database_cross_reference: SNOMEDCT_US:190790002
database_cross_reference: SNOMEDCT_US:71325002

neuronitis
type: Class
subclass of: central nervous system disease
definition: A central nervous system disease that is characterized by neuron inflammation.
PMOID: PMO:00030463
Subclass_of: central nervous system disease
Synonym: NEURONITIS
Synonym: Neuronitis
Tree Number: T10.8.2.9.4
database_cross_reference: CHV:0000008657
database_cross_reference: CSP:2042-6653
database_cross_reference: CST:NEURITIS
database_cross_reference: DO:DOID:8117
database_cross_reference: MDR:10029324
database_cross_reference: NCI:C34847

mediastinitis
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032027
Subclass_of: connective tissue disease
Synonym: Inflammation, Mediastinum
Synonym: Inflammations, Mediastinum
Synonym: MEDIASTINITIS
Synonym: Mediastinitides
Synonym: Mediastinitis
Synonym: Mediastinitis (disorder)
Synonym: Mediastinitis [Disease/Finding]
Synonym: Mediastinum Inflammation
Synonym: Mediastinum Inflammations
Synonym: mediastinitis (diagnosis)
Tree Number: T10.8.4.1.2
database_cross_reference: CCPSS:0009638
database_cross_reference: CHV:0000007839
database_cross_reference: DO:DOID:819
database_cross_reference: DXP:U002535
database_cross_reference: ICD10CM:J98.51
database_cross_reference: ICD9CM:519.2
database_cross_reference: MDR:10027082
database_cross_reference: MEDCIN:363470
database_cross_reference: MSH:D008480
database_cross_reference: NCI:C26827
database_cross_reference: NCI_NICHD:C26827
database_cross_reference: NDFRT:N0000001963
database_cross_reference: RCD:H5y2.
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D2-81010
database_cross_reference: SNOMEDCT_US:47597000

peritonitis
type: Class
subclass of: gastrointestinal system disease
PMOID: PMO:00033524
Subclass_of: gastrointestinal system disease
Synonym: Inflammation of the peritoneum
Synonym: PERITONITIS
Synonym: Peritoneal inflammation
Synonym: Peritonitis
Synonym: Peritonitis (disorder)
Synonym: Peritonitis NOS
Synonym: Peritonitis NOS (disorder)
Synonym: Peritonitis [Disease/Finding]
Synonym: Peritonitis of undetermined cause
Synonym: Peritonitis of unspecified cause
Tree Number: T10.8.11.7
database_cross_reference: AOD:0000005708
database_cross_reference: CCPSS:1017637
database_cross_reference: CHV:0000009530
database_cross_reference: COSTAR:U000525
database_cross_reference: CSP:0462-4760
database_cross_reference: CST:PERITONITIS
database_cross_reference: DXP:U001466
database_cross_reference: DXP:U003108
database_cross_reference: HPO:HP:0002586
database_cross_reference: ICD10:K65
database_cross_reference: ICD10:K65.9
database_cross_reference: ICD10AM:K65
database_cross_reference: ICD10AM:K65.9
database_cross_reference: ICD10CM:K65
database_cross_reference: ICD10CM:K65.9
database_cross_reference: ICD9CM:567.9
database_cross_reference: ICPC2P:D99035
database_cross_reference: LCH:U003571
database_cross_reference: LCH_NW:sh85099964
database_cross_reference: LNC:LA7463-8
database_cross_reference: MDR:10034674
database_cross_reference: MDR:10034685
database_cross_reference: MDR:10046096
database_cross_reference: MEDCIN:31298
database_cross_reference: MEDLINEPLUS:5583
database_cross_reference: MSH:D010538
database_cross_reference: MTHICD9:567.9
database_cross_reference: NCI:C26849
database_cross_reference: NCI_FDA:2252
database_cross_reference: NCI_NCI-GLOSS:CDR0000372937
database_cross_reference: NCI_NICHD:C26849
database_cross_reference: NDFRT:N0000002379
database_cross_reference: OMIM:MTHU018331
database_cross_reference: OMIM:MTHU036750
database_cross_reference: RCD:J55..
database_cross_reference: RCD:J55z.
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D5-70100
database_cross_reference: SNOMEDCT_US:155797008
database_cross_reference: SNOMEDCT_US:197188005
database_cross_reference: SNOMEDCT_US:48661000
database_cross_reference: SNOMEDCT_VET:48661000

polycythemia
type: Class
subclass of: bone marrow disease
PMOID: PMO:00033416
Subclass_of: bone marrow disease
Synonym: Abnormally shaped erythrocytes
Synonym: Erythrocythaemia
Synonym: Erythrocythemia
Synonym: POLYCYTHAEMIA
Synonym: POLYCYTHEMIA
Synonym: Polycythaemia
Synonym: Polycythaemia NOS
Synonym: Polycythaemia, NOS
Synonym: Polycythemia
Synonym: Polycythemia NOS
Tree Number: T10.8.10.7.1
database_cross_reference: AOD:0000005927
database_cross_reference: CCPSS:0037624
database_cross_reference: CHV:0000009910
database_cross_reference: COSTAR:594
database_cross_reference: CSP:0427-4465
database_cross_reference: CST:POLYCYTHEMIA
database_cross_reference: DO:DOID:8432
database_cross_reference: DXP:U003191
database_cross_reference: HPO:HP:0001901
database_cross_reference: ICD10CM:D75.1
database_cross_reference: LCH:U003753
database_cross_reference: LCH_NW:sh85104610
database_cross_reference: MDR:10036051
database_cross_reference: MDR:10036055
database_cross_reference: MDR:10036058
database_cross_reference: MEDCIN:363009
database_cross_reference: MSH:D011086
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000162
database_cross_reference: MTH:U000165
database_cross_reference: NCI:C26863
database_cross_reference: NCI_NICHD:C26863
database_cross_reference: NDFRT:N0000002453
database_cross_reference: OMIM:MTHU006480
database_cross_reference: RCD:X20D8
database_cross_reference: RCDAE:X20D8
database_cross_reference: SNM:M-77700
database_cross_reference: SNM:U000386
database_cross_reference: SNMI:DC-38000
database_cross_reference: SNOMEDCT_US:109992005
database_cross_reference: SNOMEDCT_US:127062003
database_cross_reference: SNOMEDCT_US:165401000
database_cross_reference: SNOMEDCT_US:44865000

thyroid malformation
type: Class
subclass of: thyroid gland disease
PMOID: PMO:00033157
Subclass_of: thyroid gland disease
Synonym: Thyroid Gland Malformation
Synonym: Thyroid Malformation
Synonym: Thyroid malformation
Synonym: Thyroid malformation NOS
Tree Number: T10.8.8.3.1
database_cross_reference: DO:DOID:8433
database_cross_reference: MDR:10048655
database_cross_reference: MDR:10062125
database_cross_reference: NCI:C27331

intestinal obstruction
type: Class
subclass of: intestinal disease
PMOID: PMO:00033530
Subclass_of: intestinal disease
Synonym: BOWEL OBSTRUCTION
Synonym: Bowel Obstruction
Synonym: Bowel obstruction
Synonym: INTESTINAL OBSTRUCTION
Synonym: INTESTINE, OBSTRUCTION
Synonym: IO - Intestinal obstruction
Synonym: Intestinal Obstruction
Synonym: Intestinal Obstruction [Disease/Finding]
Synonym: Intestinal Obstructions
Synonym: Intestinal blockage
Tree Number: T10.8.11.8.4
database_cross_reference: AOD:0000005617
database_cross_reference: CCPSS:1017976
database_cross_reference: CHV:0000006859
database_cross_reference: CSP:1248-6029
database_cross_reference: CST:OBSTRUCT INTEST
database_cross_reference: DO:DOID:8437
database_cross_reference: DXP:U000944
database_cross_reference: DXP:U002140
database_cross_reference: HPO:HP:0005214
database_cross_reference: ICD10CM:K56.60
database_cross_reference: ICD10CM:K56.69
database_cross_reference: ICD9CM:560.9
database_cross_reference: ICPC2P:D99014
database_cross_reference: ICPC2P:D99057
database_cross_reference: LCH_NW:sh85067596
database_cross_reference: MDR:10006055
database_cross_reference: MDR:10022687
database_cross_reference: MDR:10022690
database_cross_reference: MDR:10029937
database_cross_reference: MDR:10029958
database_cross_reference: MDR:10045979
database_cross_reference: MEDLINEPLUS:5275
database_cross_reference: MSH:D007415
database_cross_reference: MTH:326
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:560.9
database_cross_reference: NCI:C9175
database_cross_reference: NCI_NICHD:C9175
database_cross_reference: NDFRT:N0000001702
database_cross_reference: OMIM:MTHU020587
database_cross_reference: OMIM:MTHU022262
database_cross_reference: PDQ:CDR0000040610
database_cross_reference: RCD:J50z.
database_cross_reference: RCD:J50z0
database_cross_reference: RCD:J50z1
database_cross_reference: RCD:X305B
database_cross_reference: SNM:M-34000
database_cross_reference: SNMI:D5-42000
database_cross_reference: SNOMEDCT_US:155771002
database_cross_reference: SNOMEDCT_US:155777003
database_cross_reference: SNOMEDCT_US:197072007
database_cross_reference: SNOMEDCT_US:197073002
database_cross_reference: SNOMEDCT_US:197074008
database_cross_reference: SNOMEDCT_US:197080000
database_cross_reference: SNOMEDCT_US:266523009
database_cross_reference: SNOMEDCT_US:81060008

postgastrectomy syndrome
type: Class
subclass of: intestinal disease
PMOID: PMO:00033458
Subclass_of: intestinal disease
Synonym: Jejunal syndrome
Synonym: POST GASTRECTOMY SYNDROME
Synonym: POSTGASTRECTOMY SYNDROME
Synonym: Post gastrectomy syndrome
Synonym: Post gastric surgery syndrome
Synonym: Post-cibal syndrome
Synonym: Postgastrectomy Syndrome
Synonym: Postgastrectomy Syndromes
Synonym: Postgastrectomy Syndromes [Disease/Finding]
Synonym: Postgastrectomy syndr.
Tree Number: T10.8.11.8.29
database_cross_reference: CHV:0000009988
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0944-5314
database_cross_reference: CSP:0944-7801
database_cross_reference: CSP:1248-7189
database_cross_reference: DO:DOID:8439
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:K91.1
database_cross_reference: ICD10AM:K91.1
database_cross_reference: ICD10CM:K91.1
database_cross_reference: ICD9CM:564.2
database_cross_reference: LCH:U003776
database_cross_reference: LCH_NW:sh85105549
database_cross_reference: MDR:10036255
database_cross_reference: MDR:10036256
database_cross_reference: MDR:10036375
database_cross_reference: MEDCIN:30202
database_cross_reference: MEDCIN:334820
database_cross_reference: MSH:D011178
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:564.2
database_cross_reference: NDFRT:N0000002465
database_cross_reference: RCD:J522.
database_cross_reference: RCD:J5220
database_cross_reference: RCD:J522z
database_cross_reference: SNM:D-6230
database_cross_reference: SNM:D-6231
database_cross_reference: SNMI:D5-44200
database_cross_reference: SNOMEDCT_US:155785007
database_cross_reference: SNOMEDCT_US:197126006
database_cross_reference: SNOMEDCT_US:197128007
database_cross_reference: SNOMEDCT_US:197129004
database_cross_reference: SNOMEDCT_US:266527005
database_cross_reference: SNOMEDCT_US:80193009

Aicardi syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.
PMOID: PMO:00025145
Subclass_of: syndrome
Synonym: AIC
Synonym: AIC - Aicardi syndrome
Synonym: AICARDI SYNDROME
Synonym: Agenesis of Corpus Callosum with Chorioretinal Abnormality
Synonym: Agenesis of Corpus Callosum with Infantile Spasms and Ocular Abnormalities
Synonym: Aicardi Syndrome
Synonym: Aicardi Syndrome [Disease/Finding]
Synonym: Aicardi's Syndrome
Synonym: Aicardi's syndrome
Synonym: Aicardi's syndrome (disorder)
Tree Number: T10.1.27
database_cross_reference: CHV:0000018184
database_cross_reference: DO:DOID:8461
database_cross_reference: JABL:15
database_cross_reference: MDR:10054935
database_cross_reference: MSH:D058540
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35256
database_cross_reference: NDFRT:N0000182168
database_cross_reference: OMIM:304050
database_cross_reference: RCD:Xa0OH
database_cross_reference: SNM:D-X412
database_cross_reference: SNMI:D4-A0532
database_cross_reference: SNOMEDCT_US:80651009

influenza
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection, located in respiratory tract, has material basis in Influenzavirus A, has material basis in Influenzavirus B, or has material basis in Influenzavirus C, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.
PMOID: PMO:00029413
Subclass_of: viral infectious disease
Synonym: FLU
Synonym: FLU SYNDROME
Synonym: Flu
Synonym: Flu syndrome
Synonym: Flu, Human
Synonym: GRIP
Synonym: Grippe
Synonym: Human Flu
Synonym: Human Influenza
Synonym: Human Influenzas
Tree Number: T10.7.2.50
database_cross_reference: BI:BI00709
database_cross_reference: CCPSS:0052277
database_cross_reference: CHV:0000006710
database_cross_reference: COSTAR:417
database_cross_reference: CSP:3100-0019
database_cross_reference: CST:FLU SYND
database_cross_reference: DO:DOID:8469
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000934
database_cross_reference: DXP:U002094
database_cross_reference: ICD10CM:J11.1
database_cross_reference: ICD9CM:487
database_cross_reference: ICPC2EENG:R80
database_cross_reference: ICPC2P:R80001
database_cross_reference: ICPC2P:R80002
database_cross_reference: LCH:U002431
database_cross_reference: LCH_NW:sh85066127
database_cross_reference: LNC:LP28598-8
database_cross_reference: MDR:10016790
database_cross_reference: MDR:10016793
database_cross_reference: MDR:10022000
database_cross_reference: MDR:10042807
database_cross_reference: MEDCIN:30986
database_cross_reference: MEDLINEPLUS:299
database_cross_reference: MSH:D007251
database_cross_reference: MTH:U002008
database_cross_reference: MTHICD9:487.1
database_cross_reference: NCI:C53482
database_cross_reference: NCI_NICHD:C53482
database_cross_reference: NDFRT:N0000171628
database_cross_reference: PSY:25260
database_cross_reference: RCD:H27..
database_cross_reference: RCD:XE0YK
database_cross_reference: SNM:D-0411
database_cross_reference: SNMI:DE-34010
database_cross_reference: SNOMEDCT_US:155559006
database_cross_reference: SNOMEDCT_US:155562009
database_cross_reference: SNOMEDCT_US:195931008
database_cross_reference: SNOMEDCT_US:266353003
database_cross_reference: SNOMEDCT_US:266393000
database_cross_reference: SNOMEDCT_US:6142004

Whipple disease
type: Class
subclass of: intestinal disease
PMOID: PMO:00033527
Subclass_of: intestinal disease
Synonym: Disease, Whipple
Synonym: Disease, Whipple's
Synonym: GRANULOMATOSIS, LIPOPHAGIC, INTESTINAL
Synonym: INTESTINAL LIPODYSTROPHY
Synonym: Intestinal Lipodystrophy
Synonym: Intestinal Whipple's disease
Synonym: Intestinal lipodystrophy
Synonym: LIPODYSTROPHY, INTESTINAL
Synonym: Lipodystrophy, Intestinal
Synonym: SPRUE, NONTROPICAL, SECONDARY
Tree Number: T10.8.11.8.1
database_cross_reference: CHV:0000007458
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1745-6360
database_cross_reference: DO:DOID:8476
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002024
database_cross_reference: ICD10CM:K90.81
database_cross_reference: ICD9CM:040.2
database_cross_reference: LCH_NW:sh86008042
database_cross_reference: MDR:10047931
database_cross_reference: MDR:10047933
database_cross_reference: MEDCIN:30259
database_cross_reference: MSH:D008061
database_cross_reference: MTHICD9:040.2
database_cross_reference: NCI:C85228
database_cross_reference: NCI_NICHD:C85228
database_cross_reference: NDFRT:N0000001851
database_cross_reference: RCD:A3A2.
database_cross_reference: SNM:D-0840
database_cross_reference: SNMI:DE-19820
database_cross_reference: SNOMEDCT_US:41545003

actinomycosis
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has material basis in Actinomyces israelii, has material basis in Actinomyces gerencseriae, has material basis in Actinomyces naeslundii, has material basis in Actinomyces odontolyticus, has material basis in Actinomyces viscosus, has material basis in Actinomyces meyeri, has material basis in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.
PMOID: PMO:00029600
Subclass_of: commensal bacterial infectious disease
Synonym: ACTINOMYCES INFECT
Synonym: ACTINOMYCOSIS
Synonym: ACTINOMYCOTIC INFECTIONS
Synonym: Actinomyces Infection
Synonym: Actinomyces Infections
Synonym: Actinomycoses
Synonym: Actinomycosis
Synonym: Actinomycosis (disorder)
Synonym: Actinomycosis NOS
Synonym: Actinomycosis [Disease/Finding]
Tree Number: T10.7.3.3.1
database_cross_reference: CCPSS:0018104
database_cross_reference: CHV:0000000671
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:8478
database_cross_reference: DXP:U000032
database_cross_reference: ICD10:A42
database_cross_reference: ICD10:A42.9
database_cross_reference: ICD10AM:A42
database_cross_reference: ICD10AM:A42.9
database_cross_reference: ICD10CM:A42
database_cross_reference: ICD10CM:A42.9
database_cross_reference: ICD9CM:039
database_cross_reference: ICD9CM:039.9
database_cross_reference: LCH:U000054
database_cross_reference: LCH_NW:sh85000715
database_cross_reference: MDR:10000620
database_cross_reference: MDR:10000624
database_cross_reference: MDR:10000626
database_cross_reference: MDR:10000627
database_cross_reference: MEDCIN:30921
database_cross_reference: MSH:D000196
database_cross_reference: MTHICD9:039.9
database_cross_reference: NCI:C34350
database_cross_reference: NDFRT:N0000000300
database_cross_reference: RCD:A39..
database_cross_reference: RCD:A39z.
database_cross_reference: RCD:A39zz
database_cross_reference: RCD:Ayu3L
database_cross_reference: RCDSY:Ayu3L
database_cross_reference: SNM:D-0111
database_cross_reference: SNMI:DE-11000
database_cross_reference: SNMI:DE-11010
database_cross_reference: SNOMEDCT_US:11817007
database_cross_reference: SNOMEDCT_US:154314007
database_cross_reference: SNOMEDCT_US:186402009
database_cross_reference: SNOMEDCT_US:186405006
database_cross_reference: SNOMEDCT_US:187335006
database_cross_reference: SNOMEDCT_US:238416009
database_cross_reference: SNOMEDCT_US:266185008
database_cross_reference: SNOMEDCT_US:50508009

rheumatic myocarditis
type: Class
subclass of: bacterial infectious disease
PMOID: PMO:00029612
Subclass_of: bacterial infectious disease
Synonym: Ac rheumat hrt dis NOS
Synonym: Active Rheumatic fever with unspecified type of heart involvement
Synonym: Active rheumatic fever with heart involvement
Synonym: Active rheumatic fever with unspecified type of heart involvement
Synonym: Acute Rheumatic Heart Disease
Synonym: Acute Rheumatic fever with unspecified type of heart involvement
Synonym: Acute rheumatic carditis
Synonym: Acute rheumatic fever with heart involvement
Synonym: Acute rheumatic fever with unspecified type of heart involvement
Synonym: Acute rheumatic heart dis.NOS
Tree Number: T10.7.3.4
database_cross_reference: DO:DOID:8481
database_cross_reference: ICD10:I01.9
database_cross_reference: ICD10AM:I01.9
database_cross_reference: ICD10CM:I01.9
database_cross_reference: ICD9CM:391.9
database_cross_reference: ICPC2P:K71016
database_cross_reference: MDR:10001057
database_cross_reference: MEDCIN:31306
database_cross_reference: MEDCIN:337705
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:391.9
database_cross_reference: NCI:C34985
database_cross_reference: RCD:G01z.
database_cross_reference: RCD:XaDyJ
database_cross_reference: SNM:D-7151
database_cross_reference: SNMI:D3-17410
database_cross_reference: SNOMEDCT_US:155270000
database_cross_reference: SNOMEDCT_US:194713007
database_cross_reference: SNOMEDCT_US:312591002
database_cross_reference: SNOMEDCT_US:367538001
database_cross_reference: SNOMEDCT_US:8805001

lung disease
type: Class
subclass of: lower respiratory tract disease
definition: A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide.
PMOID: PMO:00032507
Subclass_of: lower respiratory tract disease
Synonym: DIS PULM
Synonym: DISEASES OF THE LUNG
Synonym: DISORDER LUNG
Synonym: DISORDER PULMONARY
Synonym: Disease of lung
Synonym: Disease of lung (disorder)
Synonym: Disease of lung, NOS
Synonym: Disease, Lung
Synonym: Disease, Pulmonary
Synonym: Disease;lung
Tree Number: T10.8.5.4.1
database_cross_reference: AOD:0000005450
database_cross_reference: CCPSS:0027432
database_cross_reference: CHV:0000007568
database_cross_reference: COSTAR:628
database_cross_reference: CSP:2596-4285
database_cross_reference: CST:LUNG DIS
database_cross_reference: CST:PULM
database_cross_reference: CST:RES/LUNG
database_cross_reference: DO:DOID:850
database_cross_reference: DXP:U003269
database_cross_reference: HPO:HP:0002088
database_cross_reference: ICD10CM:J98.4
database_cross_reference: ICPC2P:R99024
database_cross_reference: LCH_NW:sh85078904
database_cross_reference: LNC:LA10531-4
database_cross_reference: LNC:LP97125-6
database_cross_reference: MDR:10013235
database_cross_reference: MDR:10013259
database_cross_reference: MDR:10025082
database_cross_reference: MDR:10025083
database_cross_reference: MDR:10037373
database_cross_reference: MDR:10048522
database_cross_reference: MDR:10049490
database_cross_reference: MDR:10051054
database_cross_reference: MEDCIN:236576
database_cross_reference: MEDLINEPLUS:484
database_cross_reference: MSH:D008171
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:518.89
database_cross_reference: NCI:C3198
database_cross_reference: NCI_NICHD:C3198
database_cross_reference: NDFRT:N0000001879
database_cross_reference: PSY:28970
database_cross_reference: PSY:42280
database_cross_reference: RCD:H58z.
database_cross_reference: SNMI:D2-50000
database_cross_reference: SNOMEDCT_US:196164004
database_cross_reference: SNOMEDCT_US:19829001
database_cross_reference: SNOMEDCT_US:266374002

Bartholin's duct cyst
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is characterized by a fluid-filled swelling in the Bartholin's glands.
PMOID: PMO:00029805
Subclass_of: female reproductive system disease
Synonym: BARTHOLIN CYST
Synonym: BARTHOLIN GLAND CYST
Synonym: BARTHOLIN GLAND, CYST
Synonym: BARTHOLIN'S GLAND CYST
Synonym: Bartholin Cyst
Synonym: Bartholin cyst
Synonym: Bartholin duct cyst
Synonym: Bartholin duct cyst (diagnosis)
Synonym: Bartholin gland cyst
Synonym: Bartholin gland cyst (diagnosis)
Tree Number: T10.8.1.4.4
database_cross_reference: CCPSS:0051187
database_cross_reference: CHV:0000001709
database_cross_reference: CHV:0000049584
database_cross_reference: COSTAR:098
database_cross_reference: COSTAR:U000065
database_cross_reference: DO:DOID:851
database_cross_reference: DXP:U000194
database_cross_reference: DXP:U000343
database_cross_reference: ICD10:N75.0
database_cross_reference: ICD10AM:N75.0
database_cross_reference: ICD10CM:N75.0
database_cross_reference: ICD9CM:616.2
database_cross_reference: ICPC2P:X99001
database_cross_reference: LNC:LP175662-8
database_cross_reference: LNC:MTHU047584
database_cross_reference: MDR:10004140
database_cross_reference: MDR:10011741
database_cross_reference: MEDCIN:277074
database_cross_reference: MEDCIN:30591
database_cross_reference: MTHICD9:616.2
database_cross_reference: NCI:C26706
database_cross_reference: RCD:K422.
database_cross_reference: SNM:M-33400
database_cross_reference: SNMI:D7-71660
database_cross_reference: SNMI:D7-71662
database_cross_reference: SNOMEDCT_US:155982004
database_cross_reference: SNOMEDCT_US:27978000
database_cross_reference: SNOMEDCT_US:57044006

barbiturate abuse
type: Class
subclass of: substance abuse
definition: A substance abuse that involves the recurring use of barbiturate drugs despite negative consequences.
PMOID: PMO:00027916
Subclass_of: substance abuse
Synonym: Barbiturate and similarly acting sedative or hypnotic abuse, in remission
Synonym: Sed,hyp,anxiolytc ab-rem
Synonym: Sedative, hypnotic or anxiolytic abuse, in remission
Tree Number: T10.3.3.2.4
database_cross_reference: DO:DOID:8519
database_cross_reference: ICD9CM:305.43
database_cross_reference: MDR:10004096
database_cross_reference: MTHICD9:305.43

gastroesophageal reflux disease
type: Class
subclass of: gastrointestinal system disease
PMOID: PMO:00033741
Subclass_of: gastrointestinal system disease
Synonym: Acid Reflux
Synonym: Acid Reflux, Gastric
Synonym: Acid reflux
Synonym: Acid reflux (finding)
Synonym: Acid reflux disease
Synonym: CARDIOESOPHAGEAL RELAXATION, GASTROESOPHAGEAL REFLUX
Synonym: ESOPHAGEAL REFLUX
Synonym: Esophageal Reflux
Synonym: Esophageal reflux
Synonym: Esophageal reflux NOS
Tree Number: T10.8.11.13
database_cross_reference: BI:BI00251
database_cross_reference: CCPSS:1001976
database_cross_reference: CCPSS:1018151
database_cross_reference: CHV:0000005382
database_cross_reference: COSTAR:288
database_cross_reference: CSP:1248-5846
database_cross_reference: CST:GI DIS
database_cross_reference: DO:DOID:8534
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0002020
database_cross_reference: ICD10:K21
database_cross_reference: ICD10AM:K21
database_cross_reference: ICD10AMAE:K21
database_cross_reference: ICD10CM:K21
database_cross_reference: ICD10CM:K21.9
database_cross_reference: ICD9CM:530.81
database_cross_reference: ICPC2P:D84004
database_cross_reference: LCH:U001928
database_cross_reference: LCH_NW:sh85053480
database_cross_reference: LNC:LP100601-6
database_cross_reference: MDR:10015389
database_cross_reference: MDR:10017884
database_cross_reference: MDR:10017885
database_cross_reference: MDR:10017924
database_cross_reference: MDR:10018203
database_cross_reference: MDR:10030182
database_cross_reference: MDR:10066874
database_cross_reference: MEDCIN:38250
database_cross_reference: MEDLINEPLUS:1653
database_cross_reference: MEDLINEPLUS:512
database_cross_reference: MSH:D005764
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:530.81
database_cross_reference: NCI:C26781
database_cross_reference: NCI:C92560
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CTCAE:E10739
database_cross_reference: NCI_NCI-GLOSS:CDR0000046558
database_cross_reference: NCI_NCI-GLOSS:CDR0000257517
database_cross_reference: NCI_NCI-GLOSS:CDR0000390277
database_cross_reference: NCI_NCI-GLOSS:CDR0000390280
database_cross_reference: NCI_NICHD:C26781
database_cross_reference: NDFRT:N0000001319
database_cross_reference: OMIM:109350
database_cross_reference: OMIM:MTHU001906
database_cross_reference: OMIM:MTHU002522
database_cross_reference: OMIM:MTHU053941
database_cross_reference: RCD:X3003
database_cross_reference: RCDAE:X3003
database_cross_reference: SNM:F-61340
database_cross_reference: SNMI:D5-30140
database_cross_reference: SNMI:F-52440
database_cross_reference: SNOMEDCT_US:102620007
database_cross_reference: SNOMEDCT_US:155673008
database_cross_reference: SNOMEDCT_US:196600005
database_cross_reference: SNOMEDCT_US:196624002
database_cross_reference: SNOMEDCT_US:235595009
database_cross_reference: SNOMEDCT_US:266498005
database_cross_reference: SNOMEDCT_US:54856001
database_cross_reference: SNOMEDCT_US:698065002

herpes zoster
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia.
PMOID: PMO:00029437
Subclass_of: viral infectious disease
Synonym: HERPES ZOSTER
Synonym: Herpes Zoster
Synonym: Herpes Zoster [Disease/Finding]
Synonym: Herpes zoster
Synonym: Herpes zoster (disorder)
Synonym: Herpes zoster NOS
Synonym: Herpes zoster NOS (disorder)
Synonym: Herpes zoster disease
Synonym: Herpes zoster infection
Synonym: Herpes zoster infection (disorder)
Tree Number: T10.7.2.69
database_cross_reference: AOD:0000004821
database_cross_reference: BI:BI00595
database_cross_reference: BI:BI00596
database_cross_reference: CCPSS:1007122
database_cross_reference: CHV:0000006108
database_cross_reference: COSTAR:365
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:3099-9793
database_cross_reference: CST:HERPES ZOSTER
database_cross_reference: DO:DOID:8536
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000839
database_cross_reference: ICD10:B02
database_cross_reference: ICD10AM:B02
database_cross_reference: ICD10CM:B02
database_cross_reference: ICD10CM:B02.9
database_cross_reference: ICD9CM:053
database_cross_reference: ICPC2EENG:S70
database_cross_reference: ICPC2P:S70001
database_cross_reference: ICPC2P:S70004
database_cross_reference: LCH:U002186
database_cross_reference: MDR:10019974
database_cross_reference: MDR:10019982
database_cross_reference: MDR:10040555
database_cross_reference: MDR:10067526
database_cross_reference: MEDCIN:30970
database_cross_reference: MEDLINEPLUS:90
database_cross_reference: MSH:D006562
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:053.9
database_cross_reference: NCI:C71079
database_cross_reference: NCI_NICHD:C71079
database_cross_reference: NDFRT:N0000001531
database_cross_reference: RCD:A53z.
database_cross_reference: RCD:X73jq
database_cross_reference: RCD:XE2x9
database_cross_reference: SNM:D-0406
database_cross_reference: SNMI:DE-32400
database_cross_reference: SNOMEDCT_US:154326002
database_cross_reference: SNOMEDCT_US:186514003
database_cross_reference: SNOMEDCT_US:186533008
database_cross_reference: SNOMEDCT_US:4740000

collagen disease
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032010
Subclass_of: connective tissue disease
Synonym: COLLAGEN DIS
Synonym: COLLAGEN DISEASE
Synonym: COLLAGEN DISORDER
Synonym: COLLAGEN DISORDER (NOS)
Synonym: Collagen Disease
Synonym: Collagen Diseases
Synonym: Collagen Diseases [Disease/Finding]
Synonym: Collagen Vascular Disease
Synonym: Collagen disease
Synonym: Collagen disease (disorder)
Tree Number: T10.8.4.1.1
database_cross_reference: CCPSS:0013328
database_cross_reference: CHV:0000003157
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0729-7550
database_cross_reference: CST:COLLAGEN DIS
database_cross_reference: DO:DOID:854
database_cross_reference: DXP:U000796
database_cross_reference: ICPC2P:L99012
database_cross_reference: LCH:U001093
database_cross_reference: LCH_NW:sh85027970
database_cross_reference: MDR:10009903
database_cross_reference: MDR:10009904
database_cross_reference: MDR:10013207
database_cross_reference: MDR:10048499
database_cross_reference: MEDCIN:38673
database_cross_reference: MSH:D003095
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:710.9
database_cross_reference: NCI:C27204
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NCI-GLOSS:CDR0000044086
database_cross_reference: NCI_NCI-GLOSS:CDR0000044127
database_cross_reference: NCI_NICHD:C27204
database_cross_reference: NDFRT:N0000000808
database_cross_reference: RCD:N00z.
database_cross_reference: SNM:D-3802
database_cross_reference: SNMI:D1-10000
database_cross_reference: SNOMEDCT_US:156458006
database_cross_reference: SNOMEDCT_US:201434000
database_cross_reference: SNOMEDCT_US:201454004
database_cross_reference: SNOMEDCT_US:268048008
database_cross_reference: SNOMEDCT_US:81573002

chronic fatigue syndrome
type: Class
subclass of: syndrome
definition: A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.
PMOID: PMO:00025152
Subclass_of: syndrome
Synonym: Akureyri disease
Synonym: Benign myalgic encephalomyelitis
Synonym: CFIDS
Synonym: CFS
Synonym: CFS (chronic fatigue syndrome)
Synonym: CFS - Chronic fatigue syndrome
Synonym: CHRONIC FATIGUE DIS
Synonym: CHRONIC FATIGUE SYNDROME
Synonym: Chronic Fatigue Disorder
Synonym: Chronic Fatigue Disorders
Tree Number: T10.1.34
database_cross_reference: AOD:0000004797
database_cross_reference: AOD:0000023160
database_cross_reference: BI:BI00746
database_cross_reference: CCPSS:0059873
database_cross_reference: CHV:0000004915
database_cross_reference: CHV:0000049539
database_cross_reference: CHV:0000049892
database_cross_reference: COSTAR:U000137
database_cross_reference: CSP:0944-7840
database_cross_reference: DO:DOID:8544
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000357
database_cross_reference: DXP:U000540
database_cross_reference: ICD10:G93.3
database_cross_reference: ICD10AM:G93.3
database_cross_reference: ICD10CM:G93.3
database_cross_reference: ICD10CM:R53.82
database_cross_reference: ICD9CM:780.71
database_cross_reference: ICPC2P:A04029
database_cross_reference: ICPC2P:A04030
database_cross_reference: ICPC2P:A04031
database_cross_reference: ICPC2P:A99008
database_cross_reference: ICPC2P:A99009
database_cross_reference: LCH_NW:sh88006956
database_cross_reference: MDR:10008874
database_cross_reference: MDR:10026978
database_cross_reference: MDR:10028414
database_cross_reference: MDR:10036322
database_cross_reference: MDR:10036323
database_cross_reference: MDR:10039246
database_cross_reference: MDR:10057244
database_cross_reference: MEDCIN:337653
database_cross_reference: MEDCIN:91312
database_cross_reference: MEDLINEPLUS:89
database_cross_reference: MSH:D015673
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3037
database_cross_reference: NCI_NCI-GLOSS:CDR0000468799
database_cross_reference: NDFRT:N0000003304
database_cross_reference: PSY:09181
database_cross_reference: RCD:Xa01F
database_cross_reference: SNM:D-0819
database_cross_reference: SNMI:DE-30100
database_cross_reference: SNMI:DE-A1200
database_cross_reference: SNOMEDCT_US:154989001
database_cross_reference: SNOMEDCT_US:154991009
database_cross_reference: SNOMEDCT_US:155062000
database_cross_reference: SNOMEDCT_US:192735003
database_cross_reference: SNOMEDCT_US:193054000
database_cross_reference: SNOMEDCT_US:247372003
database_cross_reference: SNOMEDCT_US:267683005
database_cross_reference: SNOMEDCT_US:267684004
database_cross_reference: SNOMEDCT_US:271798008
database_cross_reference: SNOMEDCT_US:51771007
database_cross_reference: SNOMEDCT_US:52702003

malignant hyperthermia
type: Class
subclass of: genetic disease
definition: A genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature.
PMOID: PMO:00028837
Subclass_of: genetic disease
Synonym: Anesthesia Hyperthermia
Synonym: Anesthesia Hyperthermias
Synonym: Anesthesia Related Hyperthermia
Synonym: Anesthesia Related Hyperthermias
Synonym: FEVER MALIGNANT
Synonym: Fever malignant
Synonym: HYPERPYREXIA MALIGNANT
Synonym: HYPERPYREXIA, FULMINATING
Synonym: HYPERPYREXIA, MALIGNANT
Synonym: HYPERTHERMIA MALIGNANT
Tree Number: T10.5.11
database_cross_reference: CCPSS:0046783
database_cross_reference: CHV:0000007696
database_cross_reference: CHV:0000058199
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2871-4352
database_cross_reference: CST:FEVER MALIGNANT
database_cross_reference: DO:DOID:8545
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000888
database_cross_reference: HPO:HP:0002047
database_cross_reference: ICD10:T88.3
database_cross_reference: ICD10AM:T88.3
database_cross_reference: ICD10AMAE:T88.3
database_cross_reference: ICD10CM:T88.3
database_cross_reference: ICD9CM:995.86
database_cross_reference: ICPC2P:A03007
database_cross_reference: LCH:U002793
database_cross_reference: LCH_NW:sh85080155
database_cross_reference: MDR:10016561
database_cross_reference: MDR:10020742
database_cross_reference: MDR:10020844
database_cross_reference: MDR:10025599
database_cross_reference: MDR:10025606
database_cross_reference: MDR:10025607
database_cross_reference: MEDCIN:311081
database_cross_reference: MEDCIN:33656
database_cross_reference: MSH:D008305
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:995.86
database_cross_reference: NCI:C84869
database_cross_reference: NCI_NICHD:C84869
database_cross_reference: NDFRT:N0000001928
database_cross_reference: OMIM:145600
database_cross_reference: OMIM:180901
database_cross_reference: OMIM:MTHU023121
database_cross_reference: RCD:SN5y0
database_cross_reference: RCD:X709O
database_cross_reference: RCDAE:SN5y0
database_cross_reference: SNM:D-1065
database_cross_reference: SNMI:DD-64B00
database_cross_reference: SNOMEDCT_US:111738008
database_cross_reference: SNOMEDCT_US:157762007
database_cross_reference: SNOMEDCT_US:213026003
database_cross_reference: SNOMEDCT_US:248453001
database_cross_reference: SNOMEDCT_US:269435009
database_cross_reference: SNOMEDCT_US:405500008
database_cross_reference: SNOMEDCT_US:405501007

chronic ulcer of skin
type: Class
subclass of: skin disease
PMOID: PMO:00033893
Subclass_of: skin disease
Synonym: Callous ulcer
Synonym: Chronic skin ulcer
Synonym: Chronic skin ulcer (disorder)
Synonym: Chronic skin ulcer NOS
Synonym: Chronic skin ulcer NOS (disorder)
Synonym: Chronic skin ulcer of unspecified site
Synonym: Chronic ulcer of skin
Synonym: Chronic ulcer of skin (disorder)
Synonym: Chronic ulcer of skin NOS
Synonym: Chronic ulcer of skin, NOS
Tree Number: T10.8.12.2.26
database_cross_reference: CCPSS:0032337
database_cross_reference: CHV:0000017602
database_cross_reference: DO:DOID:8549
database_cross_reference: ICD10CM:L98.4
database_cross_reference: ICD9CM:707
database_cross_reference: ICPC2EENG:S97
database_cross_reference: ICPC2P:S97005
database_cross_reference: MDR:10009142
database_cross_reference: MDR:10009144
database_cross_reference: MDR:10009155
database_cross_reference: MDR:10009157
database_cross_reference: MEDCIN:33110
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:M27..
database_cross_reference: RCD:M27z.
database_cross_reference: SNMI:D0-60103
database_cross_reference: SNOMEDCT_US:156423009
database_cross_reference: SNOMEDCT_US:156426001
database_cross_reference: SNOMEDCT_US:19429009
database_cross_reference: SNOMEDCT_US:201259007

herpes simplex
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.
PMOID: PMO:00029367
Subclass_of: viral infectious disease
Synonym: HERPES SIMPLEX
Synonym: HERPES SIMPLEX INFECTION
Synonym: HSV
Synonym: HSV infection
Synonym: Herpes Simplex
Synonym: Herpes Simplex Infections
Synonym: Herpes Simplex [Disease/Finding]
Synonym: Herpes simplex
Synonym: Herpes simplex (disorder)
Synonym: Herpes simplex NOS
Tree Number: T10.7.2.20
database_cross_reference: BI:BI00592
database_cross_reference: CCPSS:0000589
database_cross_reference: CCPSS:0015973
database_cross_reference: CHV:0000006105
database_cross_reference: COSTAR:364
database_cross_reference: CSP:3099-9580
database_cross_reference: CST:HERPES SIMPLEX
database_cross_reference: DO:DOID:8566
database_cross_reference: DXP:U000837
database_cross_reference: ICD10:B00
database_cross_reference: ICD10AM:B00
database_cross_reference: ICD10CM:B00
database_cross_reference: ICD10CM:B00.9
database_cross_reference: ICD9CM:054
database_cross_reference: ICPC2EENG:S71
database_cross_reference: LCH:U002185
database_cross_reference: LCH_NW:sh85060454
database_cross_reference: MDR:10019948
database_cross_reference: MDR:10019957
database_cross_reference: MDR:10063570
database_cross_reference: MEDCIN:30971
database_cross_reference: MEDLINEPLUS:286
database_cross_reference: MSH:D006561
database_cross_reference: MTH:361
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001530
database_cross_reference: PSY:22830
database_cross_reference: RCD:XE0RB
database_cross_reference: SNM:D-0404
database_cross_reference: SNMI:DE-32110
database_cross_reference: SNOMEDCT_US:154332007
database_cross_reference: SNOMEDCT_US:186534002
database_cross_reference: SNOMEDCT_US:266191005
database_cross_reference: SNOMEDCT_US:88594005

infectious mononucleosis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in inflammation, located in pharynx, has material basis in Human herpesvirus 4 and has symptom fever, has symptom fatigue, has symptom lymphadenopathy, and has symptom splenomegaly.
PMOID: PMO:00029358
Subclass_of: viral infectious disease
Synonym: FEVER, GLANDULAR
Synonym: Fever, Glandular
Synonym: Filatov's disease
Synonym: GF - Glandular fever
Synonym: Gammaherpesviral mononucleosis
Synonym: Gammaherpesviral mononucleosis (disorder)
Synonym: Glandular Fever
Synonym: Glandular fever
Synonym: IM - Infectious mononucleosis
Synonym: IM - Infective mononucleosis
Tree Number: T10.7.2.11
database_cross_reference: AOD:0000004822
database_cross_reference: AOD:0000004823
database_cross_reference: BI:BI00321
database_cross_reference: CCPSS:0046203
database_cross_reference: CCPSS:0050625
database_cross_reference: CHV:0000006696
database_cross_reference: COSTAR:415
database_cross_reference: CSP:0427-6541
database_cross_reference: DO:DOID:8568
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000933
database_cross_reference: ICD10:B27
database_cross_reference: ICD10:B27.0
database_cross_reference: ICD10:B27.9
database_cross_reference: ICD10AM:B27
database_cross_reference: ICD10AM:B27.0
database_cross_reference: ICD10AM:B27.9
database_cross_reference: ICD10CM:B27
database_cross_reference: ICD10CM:B27.0
database_cross_reference: ICD10CM:B27.9
database_cross_reference: ICD9CM:075
database_cross_reference: ICPC2EENG:A75
database_cross_reference: ICPC2P:A75001
database_cross_reference: ICPC2P:A75003
database_cross_reference: LCH_NW:sh85086955
database_cross_reference: MDR:10018300
database_cross_reference: MDR:10021914
database_cross_reference: MDR:10027909
database_cross_reference: MDR:10027923
database_cross_reference: MEDCIN:30985
database_cross_reference: MEDCIN:318366
database_cross_reference: MEDLINEPLUS:298
database_cross_reference: MSH:D007244
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:075
database_cross_reference: NCI:C34726
database_cross_reference: NCI_NICHD:C34726
database_cross_reference: NDFRT:N0000001683
database_cross_reference: OMIM:MTHU043155
database_cross_reference: RCD:A75..
database_cross_reference: RCD:A750.
database_cross_reference: RCD:AyuD5
database_cross_reference: RCDSY:AyuD5
database_cross_reference: SNM:D-0410
database_cross_reference: SNMI:DE-32710
database_cross_reference: SNOMEDCT_US:154359004
database_cross_reference: SNOMEDCT_US:186667007
database_cross_reference: SNOMEDCT_US:186668002
database_cross_reference: SNOMEDCT_US:186670006
database_cross_reference: SNOMEDCT_US:187460007
database_cross_reference: SNOMEDCT_US:26851006
database_cross_reference: SNOMEDCT_US:271558008
database_cross_reference: SNOMEDCT_US:314131007

multiple carboxylase deficiency
type: Class
subclass of: carbohydrate metabolic disorder
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves failures of carboxylation enzymes.
PMOID: PMO:00029123
Subclass_of: amino acid metabolic disorder
Subclass_of: carbohydrate metabolic disorder
Synonym: CARBOXYLASE DEFIC COMBINED
Synonym: CARBOXYLASE DEFIC MULTIPLE
Synonym: COMBINED CARBOXYLASE DEFIC
Synonym: Carboxylase Deficiencies, Combined
Synonym: Carboxylase Deficiencies, Multiple
Synonym: Carboxylase Deficiency, Combined
Synonym: Carboxylase Deficiency, Multiple
Synonym: Combined Carboxylase Deficiencies
Synonym: Combined Carboxylase Deficiency
Synonym: DEFIC COMBINED CARBOXYLASE
Tree Number: T10.6.2.11.4
Tree Number: T10.6.2.15.4
database_cross_reference: DO:DOID:857
database_cross_reference: ICD10CM:D81.81
database_cross_reference: ICD10CM:D81.819
database_cross_reference: LNC:LP172597-9
database_cross_reference: LNC:MTHU046392
database_cross_reference: MDR:10028176
database_cross_reference: MEDCIN:312772
database_cross_reference: MSH:D009100
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002049
database_cross_reference: SNOMEDCT_US:62151000119109

lichen disease
type: Class
subclass of: skin disease
PMOID: PMO:00033903
Subclass_of: skin disease
Synonym: LICHEN
Synonym: Lichen
Synonym: Lichen (disorder)
Synonym: Lichen NOS
Synonym: Lichen NOS (disorder)
Synonym: Lichen condition
Synonym: Lichen disease
Synonym: Lichen of skin
Synonym: Lichen of skin (disorder)
Synonym: Lichen unspecified
Tree Number: T10.8.12.2.28
database_cross_reference: CCPSS:0047174
database_cross_reference: CHV:0000007400
database_cross_reference: COSTAR:451
database_cross_reference: DO:DOID:8574
database_cross_reference: ICD10CM:L28.0
database_cross_reference: ICD9CM:697
database_cross_reference: ICD9CM:697.9
database_cross_reference: MDR:10024426
database_cross_reference: MDR:10024437
database_cross_reference: MEDCIN:96768
database_cross_reference: MTH:U003191
database_cross_reference: RCD:M17..
database_cross_reference: RCD:M17z.
database_cross_reference: SNMI:D0-22200
database_cross_reference: SNOMEDCT_US:156376003
database_cross_reference: SNOMEDCT_US:156379005
database_cross_reference: SNOMEDCT_US:200998004
database_cross_reference: SNOMEDCT_US:201010002
database_cross_reference: SNOMEDCT_US:88996004

acute vascular insufficiency of intestine
type: Class
subclass of: intestinal disease
PMOID: PMO:00033606
Subclass_of: intestinal disease
Synonym: ACUTE MESENTERIC ISCHEMIA
Synonym: AMI - Acute mesenteric ischaem
Synonym: AMI - Acute mesenteric ischaemia
Synonym: AMI - Acute mesenteric ischemia
Synonym: Ac vasc insuff intestine
Synonym: Acute GIT vasc.insuffic NOS
Synonym: Acute Intestinal Ischemia
Synonym: Acute intest vasc insuff
Synonym: Acute intestinal ischaemia
Synonym: Acute intestinal ischaemic syndrome
Tree Number: T10.8.11.8.18
database_cross_reference: CHV:0000000694
database_cross_reference: DO:DOID:8590
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001171
database_cross_reference: ICD9CM:557.0
database_cross_reference: MDR:10001108
database_cross_reference: MEDCIN:96830
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34356
database_cross_reference: RCD:J420z
database_cross_reference: RCD:XE0ah
database_cross_reference: RCDAE:XE0ah
database_cross_reference: SNMI:D5-41300
database_cross_reference: SNOMEDCT_US:196998009
database_cross_reference: SNOMEDCT_US:197004007
database_cross_reference: SNOMEDCT_US:91489000

scarlet fever
type: Class
subclass of: upper respiratory tract disease
definition: An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.
PMOID: PMO:00032502
Subclass_of: upper respiratory tract disease
Synonym: Fever, Scarlet
Synonym: Fevers, Scarlet
Synonym: SCARLATINA
Synonym: SCARLET FEVER
Synonym: Scarlatina
Synonym: Scarlet Fever
Synonym: Scarlet Fever [Disease/Finding]
Synonym: Scarlet Fevers
Synonym: Scarlet fever
Synonym: Scarlet fever (disorder)
Tree Number: T10.8.5.2.12
database_cross_reference: CCPSS:0038558
database_cross_reference: CHV:0000011070
database_cross_reference: COSTAR:U000605
database_cross_reference: CSP:0368-3452
database_cross_reference: DO:DOID:8596
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001703
database_cross_reference: ICD10:A38
database_cross_reference: ICD10AM:A38
database_cross_reference: ICD10CM:A38
database_cross_reference: ICD10CM:A38.9
database_cross_reference: ICD9CM:034.1
database_cross_reference: ICPC2P:A78045
database_cross_reference: ICPC2P:A78052
database_cross_reference: ICPC2P:R72001
database_cross_reference: ICPC2P:R72003
database_cross_reference: ICPC2P:R72004
database_cross_reference: LCH_NW:sh85118023
database_cross_reference: LNC:LA17017-7
database_cross_reference: MDR:10039586
database_cross_reference: MDR:10039587
database_cross_reference: MDR:10039588
database_cross_reference: MEDCIN:31358
database_cross_reference: MEDLINEPLUS:421
database_cross_reference: MSH:D012541
database_cross_reference: MTHICD9:034.1
database_cross_reference: NCI:C94575
database_cross_reference: NCI_NICHD:C94575
database_cross_reference: NDFRT:N0000002683
database_cross_reference: RCD:A341.
database_cross_reference: SNM:D-0175
database_cross_reference: SNMI:DE-14240
database_cross_reference: SNOMEDCT_US:154303009
database_cross_reference: SNOMEDCT_US:30242009

herpetic whitlow
type: Class
subclass of: herpes simplex
definition: A herpes simplex that results_in infection located_in skin of the finger, toe, or thumb, has_material_basis_in Human herpesvirus 1 and has_material_basis_in Human herpesvirus 2 and has_symptom lesions, has_symptom fever, and has_symptom swollen lymph nodes.
PMOID: PMO:00029370
Subclass_of: herpes simplex
Synonym: HERPETIC WHITLOW
Synonym: Herpes simplex whitlow
Synonym: Herpetic Whitlow
Synonym: Herpetic felon
Synonym: Herpetic whitlow
Synonym: Herpetic whitlow (disorder)
Synonym: herpetic felon
Synonym: herpetic felon (diagnosis)
Synonym: whitlow herpetic
Tree Number: T10.7.2.20.3
database_cross_reference: CCPSS:0028859
database_cross_reference: CHV:0000017313
database_cross_reference: DO:DOID:8607
database_cross_reference: ICD9CM:054.6
database_cross_reference: MDR:10020005
database_cross_reference: MEDCIN:97422
database_cross_reference: MTHICD9:054.6
database_cross_reference: NCI:C128402
database_cross_reference: NCI_NICHD:C128402
database_cross_reference: RCD:A546.
database_cross_reference: SNMI:DE-32162
database_cross_reference: SNOMEDCT_US:43891009

recurrent hypersomnia
type: Class
subclass of: sleep disorder
definition: A sleep disorder that involves recurring bouts of excessive amounts of sleepiness.
PMOID: PMO:00027895
Subclass_of: sleep disorder
Synonym: Hypersomnia, Recurrent
Synonym: Hypersomnias, Recurrent
Synonym: Recurrent Hypersomnia
Synonym: Recurrent Hypersomnias
Synonym: Recurrent hypersomnia
Synonym: Recurrent hypersomnia (disorder)
Synonym: primary recurrent hypersomnia
Tree Number: T10.3.1.7
database_cross_reference: DO:DOID:8619
database_cross_reference: ICD10CM:G47.13
database_cross_reference: ICD9CM:327.13
database_cross_reference: MSH:D006970
database_cross_reference: SNOMEDCT_US:426451004

diplegia of upper limb
type: Class
subclass of: nervous system disease
PMOID: PMO:00030166
Subclass_of: nervous system disease
Synonym: Diplegia (upper)
Synonym: Diplegia of upper limbs
Synonym: Diplegia of upper limbs (disorder)
Synonym: Diplegia, upper
Synonym: Paralysis of both upper limbs
Synonym: Upper diplegia
Synonym: diplegia upper extremities
Synonym: diplegia upper extremities (physical finding)
Synonym: paralysis of both arms
Synonym: paralysis of both arms (symptom)
Tree Number: T10.8.2.5
database_cross_reference: DO:DOID:862
database_cross_reference: ICD10:G83.0
database_cross_reference: ICD10AM:G83.0
database_cross_reference: ICD10CM:G83.0
database_cross_reference: ICD9CM:344.2
database_cross_reference: MDR:10013034
database_cross_reference: MEDCIN:203612
database_cross_reference: MEDCIN:282974
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:344.2
database_cross_reference: RCD:F242.
database_cross_reference: SNMI:DA-26050
database_cross_reference: SNOMEDCT_US:192968004
database_cross_reference: SNOMEDCT_US:54099005

measles
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.
PMOID: PMO:00029446
Subclass_of: viral infectious disease
Synonym: MEASLE
Synonym: MEASLES
Synonym: Measles
Synonym: Measles (disorder)
Synonym: Measles NOS
Synonym: Measles [Disease/Finding]
Synonym: Measles disease
Synonym: Morbilli
Synonym: RUBEOLA
Synonym: RUBEOLLA
Tree Number: T10.7.2.77
database_cross_reference: AOD:0000000016
database_cross_reference: CCPSS:0046666
database_cross_reference: CHV:0000007820
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:3100-0554
database_cross_reference: DO:DOID:8622
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001142
database_cross_reference: DXP:U002524
database_cross_reference: ICD10:B05
database_cross_reference: ICD10AM:B05
database_cross_reference: ICD10CM:B05
database_cross_reference: ICD10CM:B05.9
database_cross_reference: ICD9CM:055
database_cross_reference: ICPC2EENG:A71
database_cross_reference: ICPC2P:A71001
database_cross_reference: ICPC2P:A71002
database_cross_reference: LCH:U002846
database_cross_reference: LCH_NW:sh85082696
database_cross_reference: LNC:LA17014-4
database_cross_reference: MDR:10027011
database_cross_reference: MDR:10039282
database_cross_reference: MDR:10039290
database_cross_reference: MEDCIN:31181
database_cross_reference: MEDLINEPLUS:318
database_cross_reference: MSH:D008457
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C96406
database_cross_reference: NCI_NICHD:C96406
database_cross_reference: NDFRT:N0000001956
database_cross_reference: PSY:30190
database_cross_reference: RCD:A55..
database_cross_reference: SNM:D-0430
database_cross_reference: SNMI:DE-33910
database_cross_reference: SNOMEDCT_US:14189004
database_cross_reference: SNOMEDCT_US:154338006

nervous system disease
type: Class
subclass of: disease of anatomical entity
definition: A physical disorder that is the result of structural, biochemical or electrical abnormalities in the brain or spinal cord, or in the nerves leading to or from them, can result in symptoms such as paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain and altered levels of consciousness.
PMOID: PMO:00029882
Subclass_of: disease of anatomical entity
Synonym: Cns disorder NOS
Synonym: DISORDER NERVOUS SYSTEM
Synonym: Disease of nervous system
Synonym: Disease of nervous system (disorder)
Synonym: Disease, Nervous System
Synonym: Disease;neurological
Synonym: Diseases of the nervous system
Synonym: Diseases of the nervous system (G00-G99)
Synonym: Diseases, Nervous System
Synonym: Disorder nervous system
Tree Number: T10.8.2
database_cross_reference: AOD:0000006104
database_cross_reference: AOD:0000023588
database_cross_reference: CCPSS:0018765
database_cross_reference: CHV:0000008606
database_cross_reference: CHV:0000039004
database_cross_reference: CSP:2042-2001
database_cross_reference: CST:NER
database_cross_reference: CST:NEUROPATHY
database_cross_reference: DO:DOID:0060052
database_cross_reference: DO:DOID:863
database_cross_reference: ICD10:G00-G99.9
database_cross_reference: ICD10AM:G00-G99.9
database_cross_reference: ICD10CM:G00-G99
database_cross_reference: ICD10CM:G98
database_cross_reference: ICD10CM:G98.8
database_cross_reference: ICD9CM:349.9
database_cross_reference: ICPC2P:N99037
database_cross_reference: LCH_NW:sh85090924
database_cross_reference: LNC:LA10590-0
database_cross_reference: MDR:10013242
database_cross_reference: MDR:10029202
database_cross_reference: MDR:10029203
database_cross_reference: MDR:10029205
database_cross_reference: MDR:10029286
database_cross_reference: MDR:10029298
database_cross_reference: MDR:10045843
database_cross_reference: MEDCIN:38674
database_cross_reference: MEDLINEPLUS:341
database_cross_reference: MSH:D009422
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:349.9
database_cross_reference: NCI:C26835
database_cross_reference: NCI_NICHD:C26835
database_cross_reference: NDFRT:N0000002159
database_cross_reference: PSY:33540
database_cross_reference: PSY:33720
database_cross_reference: RCD:X000E
database_cross_reference: RCD:Xa3fJ
database_cross_reference: SNM:D-8002
database_cross_reference: SNM:F-80002
database_cross_reference: SNOMEDCT_US:118940003
database_cross_reference: SNOMEDCT_US:154981003
database_cross_reference: SNOMEDCT_US:155262005
database_cross_reference: SNOMEDCT_US:192641002
database_cross_reference: SNOMEDCT_US:267679005
database_cross_reference: SNOMEDCT_US:286946008
database_cross_reference: SNOMEDCT_VET:118940003

chronic intestinal vascular insufficiency
type: Class
subclass of: intestinal disease
PMOID: PMO:00033621
Subclass_of: intestinal disease
Synonym: CMI - Chron mesenteric ischaem
Synonym: CMI - Chronic mesenteric ischaemia
Synonym: CMI - Chronic mesenteric ischemia
Synonym: CMI - chronic mesenteric ischaemia
Synonym: Chr vasc insuff intest
Synonym: Chro intest vasc insuff
Synonym: Chronic GIT vasc.insuffic.NOS
Synonym: Chronic intestinal ischaemia
Synonym: Chronic intestinal ischaemic syndrome
Synonym: Chronic intestinal ischaemic syndrome, NOS
Tree Number: T10.8.11.8.23
database_cross_reference: CHV:0000017549
database_cross_reference: CHV:0000028384
database_cross_reference: DO:DOID:8633
database_cross_reference: DXP:U001172
database_cross_reference: ICD9CM:557.1
database_cross_reference: MDR:10009161
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:J421z
database_cross_reference: RCD:XE0ai
database_cross_reference: RCDAE:XE0ai
database_cross_reference: SNM:D-6182
database_cross_reference: SNMI:D5-41500
database_cross_reference: SNOMEDCT_US:111354009
database_cross_reference: SNOMEDCT_US:197005008
database_cross_reference: SNOMEDCT_US:197008005
database_cross_reference: SNOMEDCT_US:241154007
database_cross_reference: SNOMEDCT_US:266448009

prostate carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the prostate.
PMOID: PMO:00027308
Subclass_of: in situ carcinoma
Synonym: Adenocarcinoma in situ of Prostate
Synonym: Adenocarcinoma in situ of the Prostate
Synonym: CIS (Carcinoma in situ) of prostate
Synonym: CIS - Carc in situ of prostate
Synonym: CIS - Carcinoma in situ of prostate
Synonym: Ca in situ prostate
Synonym: Cancer in situ of prostate
Synonym: Carcinoma in situ of prostate
Synonym: Carcinoma in situ of prostate (disorder)
Synonym: Grade 3 PIN
Tree Number: T10.2.2.3.23
database_cross_reference: DO:DOID:8634
database_cross_reference: ICD10:D07.5
database_cross_reference: ICD10AM:D07.5
database_cross_reference: ICD10CM:D07.5
database_cross_reference: ICD9CM:233.4
database_cross_reference: MDR:10007385
database_cross_reference: MEDCIN:97978
database_cross_reference: MTH:U000700
database_cross_reference: NCI:C3642
database_cross_reference: RCD:B834.
database_cross_reference: SNMI:D7-F0462
database_cross_reference: SNOMEDCT_US:128640002
database_cross_reference: SNOMEDCT_US:92691004

duodenitis
type: Class
subclass of: intestinal disease
PMOID: PMO:00033541
Subclass_of: intestinal disease
Synonym: DUODENITIS
Synonym: Duodenitis
Synonym: Duodenitis (disorder)
Synonym: Duodenitis [Disease/Finding]
Synonym: Duodenitis, NOS
Synonym: Hemorrhagic duodenitis
Synonym: duodenitis (diagnosis)
Synonym: duodenitis nos
Tree Number: T10.8.11.8.6
database_cross_reference: CCPSS:1005695
database_cross_reference: CHV:0000004180
database_cross_reference: COSTAR:U000207
database_cross_reference: CST:DUODENITIS
database_cross_reference: DO:DOID:8643
database_cross_reference: ICD10:K29.8
database_cross_reference: ICD10AM:K29.8
database_cross_reference: ICD10CM:K29.8
database_cross_reference: ICD9CM:535.6
database_cross_reference: ICPC2P:D87005
database_cross_reference: MDR:10013864
database_cross_reference: MEDCIN:33927
database_cross_reference: MSH:D004382
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C94409
database_cross_reference: NCI_NCI-GLOSS:CDR0000330166
database_cross_reference: NDFRT:N0000001009
database_cross_reference: RCD:J157.
database_cross_reference: SNMI:D5-34800
database_cross_reference: SNOMEDCT_US:155715004
database_cross_reference: SNOMEDCT_US:72007001

gastroduodenitis
type: Class
subclass of: peptic ulcer disease
PMOID: PMO:00033433
Subclass_of: peptic ulcer disease
Synonym: Other specified gastritis
Synonym: Other specified gastritis (disorder)
Synonym: Other specified gastritis NOS
Synonym: Other specified gastritis NOS (disorder)
Tree Number: T10.8.11.1.3
database_cross_reference: DO:DOID:8644
database_cross_reference: ICD9CM:535.4
database_cross_reference: MDR:10032739
database_cross_reference: RCD:J154.
database_cross_reference: RCD:J154z
database_cross_reference: SNOMEDCT_US:196737009
database_cross_reference: SNOMEDCT_US:196742001

substance-induced psychosis
type: Class
subclass of: psychotic disorder
PMOID: PMO:00028190
Subclass_of: psychotic disorder
Synonym: Other specified transient mental disorders due to conditions classified elsewhere, other
Synonym: Other specified transient organic mental disorder
Synonym: Other specified transient organic mental disorders
Synonym: Transient mental dis NEC
Tree Number: T10.3.12.1.5
database_cross_reference: DO:DOID:8646
database_cross_reference: ICD9CM:293.89
database_cross_reference: MDR:10032907
database_cross_reference: MDR:10032908
database_cross_reference: MTHICD9:293.89

vasculitis
type: Class
subclass of: vascular disease
definition: A vascular disease that is characterized by inflammation of the blood vessels.
PMOID: PMO:00031827
Subclass_of: vascular disease
Synonym: ANGIITIS
Synonym: Angiitides
Synonym: Angiitis
Synonym: Angiitis, NOS
Synonym: Inflammation of blood vessel
Synonym: VASCULITIS
Synonym: VASCULITIS NON SPECIFIC
Synonym: Vasculitides
Synonym: Vasculitis
Synonym: Vasculitis (disorder)
Tree Number: T10.8.3.3.3
database_cross_reference: AOD:0000005422
database_cross_reference: AOD:0000023363
database_cross_reference: AOD:0000023364
database_cross_reference: CCPSS:0035101
database_cross_reference: CCPSS:1018277
database_cross_reference: CHV:0000012913
database_cross_reference: COSTAR:U000712
database_cross_reference: CSP:0571-9056
database_cross_reference: CST:VASCULITIS
database_cross_reference: DO:DOID:865
database_cross_reference: DXP:U004354
database_cross_reference: HPO:HP:0002633
database_cross_reference: ICPC2P:K99016
database_cross_reference: LCH:U004901
database_cross_reference: LCH_NW:sh85142363
database_cross_reference: LNC:LA17783-4
database_cross_reference: MDR:10002369
database_cross_reference: MDR:10047112
database_cross_reference: MDR:10047115
database_cross_reference: MDR:10047128
database_cross_reference: MEDCIN:90233
database_cross_reference: MEDLINEPLUS:1424
database_cross_reference: MSH:D014657
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26912
database_cross_reference: NCI_CTCAE:E13837
database_cross_reference: NCI_NICHD:C26912
database_cross_reference: NDFRT:N0000003113
database_cross_reference: OMIM:MTHU018875
database_cross_reference: RCD:G76B.
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D3-80650
database_cross_reference: SNOMEDCT_US:195375002
database_cross_reference: SNOMEDCT_US:266325003
database_cross_reference: SNOMEDCT_US:31996006
database_cross_reference: SNOMEDCT_US:393589007
database_cross_reference: SNOMEDCT_VET:31996006

chickenpox
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.
PMOID: PMO:00029427
Subclass_of: viral infectious disease
Synonym: VARICELLA UNCOMPLICATED
Synonym: Varicella uncomplicated
Synonym: Varicella w'out complicatns
Synonym: Varicella with no complication NOS
Synonym: Varicella with no complication NOS (disorder)
Synonym: Varicella without complication
Synonym: Varicella without complications
Synonym: Varicella without mention of complication
Synonym: Varicella+no complication NOS
Synonym: [X]Varicella w'out complicatns
Tree Number: T10.7.2.61
database_cross_reference: CCPSS:0035142
database_cross_reference: DO:DOID:8659
database_cross_reference: ICD10:B01.9
database_cross_reference: ICD10AM:B01.9
database_cross_reference: ICD10CM:B01.9
database_cross_reference: ICD9CM:052.9
database_cross_reference: MDR:10046982
database_cross_reference: MEDCIN:358863
database_cross_reference: RCD:A52z.
database_cross_reference: RCD:AyuA3
database_cross_reference: RCDSY:AyuA3
database_cross_reference: SNOMEDCT_US:186513009
database_cross_reference: SNOMEDCT_US:187420006

vein disease
type: Class
subclass of: vascular disease
definition: A vascular disease that is located_in a vein.
PMOID: PMO:00031983
Subclass_of: vascular disease
Synonym: Other venous embolism & thrombosis
Synonym: Other venous embolism and thrombosis
Synonym: Other venous embolism and thrombosis (disorder)
Synonym: Other venous embolus/thrombus
Synonym: Venous embolism and thrombosis, other
Tree Number: T10.8.3.3.10
database_cross_reference: DO:DOID:866
database_cross_reference: ICD10:I82
database_cross_reference: ICD10AM:I82
database_cross_reference: ICD10CM:I82
database_cross_reference: ICD9CM:453
database_cross_reference: MDR:10033035
database_cross_reference: MDR:10033036
database_cross_reference: MDR:10047225
database_cross_reference: RCD:G82..
database_cross_reference: SNOMEDCT_US:195435006

lip carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the lip.
PMOID: PMO:00027289
Subclass_of: in situ carcinoma
Synonym: Ca in situ oral cav/phar
Synonym: Ca-in-situ lip,oral,pharynx
Synonym: Ca-in-situ oral,pharynx NOS
Synonym: Carcinoma in situ of lip, oral cavity and pharynx
Synonym: Carcinoma in situ of lip, oral cavity and pharynx (disorder)
Synonym: Carcinoma in situ of lip, oral cavity and pharynx NOS
Synonym: Carcinoma in situ of lip, oral cavity and pharynx NOS (disorder)
Synonym: Carcinoma in situ of lip, oral cavity and/or pharynx
Synonym: Carcinoma in situ of lip, oral cavity and/or pharynx (disorder)
Synonym: Carcinoma in situ of lip, oral cavity, and pharynx
Tree Number: T10.2.2.3.8
database_cross_reference: DO:DOID:8661
database_cross_reference: ICD10:D00.0
database_cross_reference: ICD10AM:D00.0
database_cross_reference: ICD10CM:D00.0
database_cross_reference: ICD9CM:230.0
database_cross_reference: MDR:10007371
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:230.0
database_cross_reference: RCD:B800z
database_cross_reference: RCD:XE2rm
database_cross_reference: SNOMEDCT_US:189210009
database_cross_reference: SNOMEDCT_US:189213006
database_cross_reference: SNOMEDCT_US:271325000

eating disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health.
PMOID: PMO:00027983
Subclass_of: specific developmental disorder
Synonym: -- Eating Disorder
Synonym: 9-13 EATING DISORDERS
Synonym: Disorder, Eating
Synonym: Disorders, Eating
Synonym: EATING DISORDER
Synonym: EATING DISORDER NOS
Synonym: EATING DISORDERS
Synonym: Eating Disorder
Synonym: Eating Disorders
Synonym: Eating and Feeding Disorders
Tree Number: T10.3.5.1.3
database_cross_reference: AOD:0000006751
database_cross_reference: BI:BI00679
database_cross_reference: CCPSS:0058104
database_cross_reference: CHV:0000004237
database_cross_reference: COSTAR:U000216
database_cross_reference: CSP:2483-6430
database_cross_reference: DO:DOID:8670
database_cross_reference: ICD10:F50
database_cross_reference: ICD10:F50.9
database_cross_reference: ICD10AM:F50
database_cross_reference: ICD10AM:F50.9
database_cross_reference: ICD10CM:F50
database_cross_reference: ICD10CM:F50.9
database_cross_reference: ICD9CM:307.50
database_cross_reference: LCH_NW:sh86004209
database_cross_reference: LNC:LA10580-1
database_cross_reference: MDR:10014062
database_cross_reference: MDR:10014066
database_cross_reference: MDR:10014067
database_cross_reference: MEDCIN:273152
database_cross_reference: MEDLINEPLUS:237
database_cross_reference: MSH:D001068
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:307.50
database_cross_reference: NCI:C89332
database_cross_reference: NCI_NICHD:C89332
database_cross_reference: NDFRT:N0000000457
database_cross_reference: PSY:15825
database_cross_reference: RCD:Eu50.
database_cross_reference: RCD:Eu50z
database_cross_reference: RCD:X00Sx
database_cross_reference: RCDSY:Eu50.
database_cross_reference: RCDSY:Eu50z
database_cross_reference: SNMI:D9-13000
database_cross_reference: SNOMEDCT_US:192444003
database_cross_reference: SNOMEDCT_US:192452000
database_cross_reference: SNOMEDCT_US:72366004

perinatal necrotizing enterocolitis
type: Class
subclass of: gastrointestinal system disease
PMOID: PMO:00033523
Subclass_of: gastrointestinal system disease
Synonym: ENTEROCOLITIS NECROTIZING
Synonym: ENTEROCOLITIS, NECROTIZING
Synonym: Enterocolitis necrotising
Synonym: Enterocolitis necrotizing
Synonym: Enterocolitis, Necrotizing
Synonym: Enterocolitis, Necrotizing [Disease/Finding]
Synonym: Necrotising enterocolitis
Synonym: Necrotizing Enterocolitis
Synonym: Necrotizing enterocolitis
Synonym: Necrotizing enterocolitis in fetus OR newborn
Tree Number: T10.8.11.6
database_cross_reference: DO:DOID:8677
database_cross_reference: DXP:U000563
database_cross_reference: ICD10CM:K55.3
database_cross_reference: ICD10CM:K55.30
database_cross_reference: MDR:10014899
database_cross_reference: MDR:10028884
database_cross_reference: MDR:10055642
database_cross_reference: MDR:10055646
database_cross_reference: MEDCIN:363431
database_cross_reference: MSH:D020345
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000004121

skin carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: A carcinoma in situ that is characterized by the spread of cancer in skin and the lack of invasion of surrounding tissues.
PMOID: PMO:00027295
Subclass_of: in situ carcinoma
Synonym: Ca in situ skin NOS
Synonym: Cancer in situ of skin
Synonym: Carcinoma in situ of Skin
Synonym: Carcinoma in situ of skin
Synonym: Carcinoma in situ of skin (disorder)
Synonym: Carcinoma in situ of skin NOS
Synonym: Carcinoma in situ of skin NOS (disorder)
Synonym: Carcinoma in situ of skin, NOS
Synonym: Carcinoma in situ of skin, site unspecified
Synonym: Carcinoma in situ of skin, unspecified
Tree Number: T10.2.2.3.14
database_cross_reference: DO:DOID:8687
database_cross_reference: ICD10:D04
database_cross_reference: ICD10:D04.9
database_cross_reference: ICD10AM:D04
database_cross_reference: ICD10AM:D04.9
database_cross_reference: ICD10CM:D04
database_cross_reference: ICD10CM:D04.9
database_cross_reference: ICD9CM:232
database_cross_reference: ICD9CM:232.9
database_cross_reference: MDR:10007390
database_cross_reference: MDR:10007398
database_cross_reference: MEDCIN:97802
database_cross_reference: MTH:U000746
database_cross_reference: NCI:C3640
database_cross_reference: NCI_NCI-GLOSS:CDR0000609744
database_cross_reference: NCI_NCI-GLOSS:CDR0000609745
database_cross_reference: RCD:B82..
database_cross_reference: RCD:B82z.
database_cross_reference: RCD:ByuF9
database_cross_reference: RCDSY:ByuF9
database_cross_reference: SNMI:D0-F0002
database_cross_reference: SNOMEDCT_US:189334002
database_cross_reference: SNOMEDCT_US:190181002
database_cross_reference: SNOMEDCT_US:92749008

neuropathy
type: Class
subclass of: peripheral nervous system disease
definition: A nervous system disease that is located_in nerves or nerve cells.
PMOID: PMO:00029907
Subclass_of: peripheral nervous system disease
Synonym: NEUROPATHY
Synonym: NEUROPATHY - (NOS)
Synonym: Neuropathy
Synonym: Neuropathy (disorder)
Synonym: Neuropathy (nerve damage)
Synonym: Neuropathy - (NOS)
Synonym: Neuropathy NOS
Synonym: Neuropathy, NOS
Synonym: disorders neuropathy
Synonym: nerve disorders
Tree Number: T10.8.2.4.5
database_cross_reference: AOD:0000006110
database_cross_reference: BI:BI00553
database_cross_reference: CCPSS:1009040
database_cross_reference: CHV:0000035183
database_cross_reference: COSTAR:516
database_cross_reference: CST:NEUROPATHY
database_cross_reference: DO:DOID:870
database_cross_reference: HPO:HP:0009830
database_cross_reference: ICD10CM:G62.9
database_cross_reference: ICPC2P:N94010
database_cross_reference: LCH:U005825
database_cross_reference: MDR:10029328
database_cross_reference: MDR:10029329
database_cross_reference: MDR:10029330
database_cross_reference: MEDCIN:31875
database_cross_reference: MEDCIN:338712
database_cross_reference: MEDLINEPLUS:1095
database_cross_reference: MEDLINEPLUS:1465
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4731
database_cross_reference: NCI_FDA:1983
database_cross_reference: NCI_NCI-GLOSS:CDR0000046041
database_cross_reference: NCI_NICHD:C4731
database_cross_reference: OMIM:MTHU016030
database_cross_reference: PSY:33800
database_cross_reference: RCD:XC0eJ
database_cross_reference: SNM:D-8X30
database_cross_reference: SNMI:DA-40000
database_cross_reference: SNOMEDCT_US:193167000
database_cross_reference: SNOMEDCT_US:264554005
database_cross_reference: SNOMEDCT_US:277317008
database_cross_reference: SNOMEDCT_US:277878001
database_cross_reference: SNOMEDCT_US:386033004
database_cross_reference: SNOMEDCT_US:42658009

genital herpes
type: Class
subclass of: herpes simplex
definition: A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands.
PMOID: PMO:00029368
Subclass_of: herpes simplex
Synonym: GENITAL HERPES
Synonym: GENITAL HERPES SIMPLEX
Synonym: Genital Herpes
Synonym: Genital Herpes Simplex
Synonym: Genital herpes
Synonym: Genital herpes (disorder)
Synonym: Genital herpes NOS
Synonym: Genital herpes simplex
Synonym: Genital herpes simplex (disorder)
Synonym: Genital herpes simplex NOS
Tree Number: T10.7.2.20.1
database_cross_reference: AOD:0000004817
database_cross_reference: BI:BI00440
database_cross_reference: CCPSS:1017515
database_cross_reference: CCPSS:1017847
database_cross_reference: CHV:0000006102
database_cross_reference: COSTAR:328
database_cross_reference: COSTAR:362
database_cross_reference: COSTAR:363
database_cross_reference: CSP:3099-9627
database_cross_reference: DO:DOID:8704
database_cross_reference: ICD9CM:054.1
database_cross_reference: ICD9CM:054.10
database_cross_reference: LCH:U002184
database_cross_reference: LCH_NW:sh85060453
database_cross_reference: MDR:10018150
database_cross_reference: MDR:10018151
database_cross_reference: MDR:10019937
database_cross_reference: MDR:10019938
database_cross_reference: MDR:10073931
database_cross_reference: MEDCIN:351375
database_cross_reference: MEDLINEPLUS:5863
database_cross_reference: MSH:D006558
database_cross_reference: MTH:328
database_cross_reference: MTH:363
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C14364
database_cross_reference: NCI_NICHD:C14364
database_cross_reference: NDFRT:N0000001527
database_cross_reference: PSY:20885
database_cross_reference: PSY:22825
database_cross_reference: RCD:A541.
database_cross_reference: RCD:A541z
database_cross_reference: RCD:XE2vG
database_cross_reference: SNMI:DE-32120
database_cross_reference: SNOMEDCT_US:154333002
database_cross_reference: SNOMEDCT_US:186536000
database_cross_reference: SNOMEDCT_US:186539007
database_cross_reference: SNOMEDCT_US:271463009
database_cross_reference: SNOMEDCT_US:33839006

in situ carcinoma
type: Class
subclass of: pre-malignant neoplasm
definition: A carcinoma that is an early development defined by the absence of invasion of surrounding tissues.
PMOID: PMO:00027281
Subclass_of: pre-malignant neoplasm
Synonym: CARCINOMA IN SITU
Synonym: CARCINOMA, IN SITU, MALIGNANT
Synonym: CIS
Synonym: CIS - Carcinoma in situ
Synonym: Ca in situ NOS
Synonym: Cancer in situ
Synonym: Carcinoma In Situ
Synonym: Carcinoma in Situ
Synonym: Carcinoma in Situ [Disease/Finding]
Synonym: Carcinoma in situ
Tree Number: T10.2.2.3
database_cross_reference: CCPSS:1013022
database_cross_reference: CHV:0000002417
database_cross_reference: DO:DOID:8719
database_cross_reference: ICD10:D09.9
database_cross_reference: ICD10AM:D09.9
database_cross_reference: ICD10AM:M8010/2
database_cross_reference: ICD10CM:D09.9
database_cross_reference: ICD9CM:230-234.99
database_cross_reference: ICD9CM:234.9
database_cross_reference: ICPC2P:A79004
database_cross_reference: MDR:10007353
database_cross_reference: MDR:10007402
database_cross_reference: MDR:10061450
database_cross_reference: MEDCIN:99806
database_cross_reference: MSH:D002278
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:234.9
database_cross_reference: NCI:C2917
database_cross_reference: NCI_CDISC:C2917
database_cross_reference: NCI_NCI-GLOSS:CDR0000046488
database_cross_reference: NCI_NCI-GLOSS:CDR0000638178
database_cross_reference: NDFRT:N0000000665
database_cross_reference: RCD:B8z..
database_cross_reference: RCD:BB11.
database_cross_reference: RCD:XE2xD
database_cross_reference: RCD:Xa986
database_cross_reference: RCDAE:XE2xD
database_cross_reference: RCDSY:BB11.
database_cross_reference: SNM:M-8010/2
database_cross_reference: SNMI:M-80102
database_cross_reference: SNOMEDCT_US:109355002
database_cross_reference: SNOMEDCT_US:154635000
database_cross_reference: SNOMEDCT_US:154640008
database_cross_reference: SNOMEDCT_US:189208007
database_cross_reference: SNOMEDCT_US:189359006
database_cross_reference: SNOMEDCT_US:189548003
database_cross_reference: SNOMEDCT_US:271528002
database_cross_reference: SNOMEDCT_US:399919001
database_cross_reference: SNOMEDCT_US:68956006

vascular dementia
type: Class
subclass of: dementia
definition: A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.
PMOID: PMO:00028212
Subclass_of: dementia
Synonym: DEMENTIA MULTI INFARCT
Synonym: DEMENTIA MULTIINFARCT
Synonym: DEMENTIA, MULTI-INFARCT
Synonym: Dementia (Multi Infarct)
Synonym: Dementia Multi Infarct
Synonym: Dementia Multi-Infarct
Synonym: Dementia Multi-Infarcts
Synonym: Dementia multi-infarct
Synonym: Dementia, Multi Infarct
Synonym: Dementia, Multi-Infarct
Tree Number: T10.3.12.3.1
database_cross_reference: AOD:0000006463
database_cross_reference: BI:BI00531
database_cross_reference: CCPSS:0046072
database_cross_reference: CHV:0000003682
database_cross_reference: CSP:0485-6862
database_cross_reference: DO:DOID:8725
database_cross_reference: DXP:U000452
database_cross_reference: ICD10:F01.1
database_cross_reference: ICD10AM:F01.1
database_cross_reference: MDR:10012288
database_cross_reference: MDR:10028153
database_cross_reference: MEDCIN:350255
database_cross_reference: MSH:D015161
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:290.4
database_cross_reference: NCI:C34522
database_cross_reference: NDFRT:N0000003192
database_cross_reference: PSY:13398
database_cross_reference: PSY:32442
database_cross_reference: RCD:Xa0lH
database_cross_reference: SNMI:D9-22300
database_cross_reference: SNOMEDCT_US:191462009
database_cross_reference: SNOMEDCT_US:192167008
database_cross_reference: SNOMEDCT_US:56267009

milker's nodule
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.
PMOID: PMO:00029355
Subclass_of: viral infectious disease
Synonym: MILKER'S NODULES
Synonym: Milker Nodes
Synonym: Milker's Node
Synonym: Milker's Nodes
Synonym: Milker's node
Synonym: Milker's nodes
Synonym: Milker's nodule
Synonym: Milker's nodules
Synonym: Milker's nodules (diagnosis)
Synonym: Milkers Nodes
Tree Number: T10.7.2.8
database_cross_reference: CHV:0000008152
database_cross_reference: DO:DOID:8729
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001421
database_cross_reference: ICD10CM:B08.04
database_cross_reference: ICD9CM:051.1
database_cross_reference: ICD9CM:051.9
database_cross_reference: MDR:10033976
database_cross_reference: MDR:10033978
database_cross_reference: MDR:10037115
database_cross_reference: MDR:10053045
database_cross_reference: MEDCIN:31420
database_cross_reference: MEDCIN:99577
database_cross_reference: MSH:D011213
database_cross_reference: MTHICD9:051.1
database_cross_reference: RCD:A511.
database_cross_reference: RCD:A51z.
database_cross_reference: SNM:D-0447
database_cross_reference: SNM:D-0455
database_cross_reference: SNMI:DE-31510
database_cross_reference: SNOMEDCT_US:154344005
database_cross_reference: SNOMEDCT_US:186507000
database_cross_reference: SNOMEDCT_US:266193008
database_cross_reference: SNOMEDCT_US:27240009

smallpox
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection located in skin, has material basis in Variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. The infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.
PMOID: PMO:00029432
Subclass_of: viral infectious disease
Synonym: Classical smallpox
Synonym: Ordinary smallpox
Synonym: SMALLPOX
Synonym: Small pox
Synonym: Smallpox
Synonym: Smallpox (disorder)
Synonym: Smallpox NOS
Synonym: Smallpox NOS (disorder)
Synonym: Smallpox [Disease/Finding]
Synonym: Smallpox, NOS
Tree Number: T10.7.2.66
database_cross_reference: CHV:0000011422
database_cross_reference: CSP:3100-0734
database_cross_reference: DO:DOID:8736
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001754
database_cross_reference: DXP:U003721
database_cross_reference: ICD10:B03
database_cross_reference: ICD10AM:B03
database_cross_reference: ICD10CM:B03
database_cross_reference: ICD9CM:050
database_cross_reference: ICD9CM:050.9
database_cross_reference: ICPC2P:A76008
database_cross_reference: LCH:U004344
database_cross_reference: LCH_NW:sh85123612
database_cross_reference: MDR:10041197
database_cross_reference: MDR:10041198
database_cross_reference: MEDCIN:31069
database_cross_reference: MEDLINEPLUS:1567
database_cross_reference: MSH:D012899
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35027
database_cross_reference: NCI_NICHD:C35027
database_cross_reference: NDFRT:N0000002776
database_cross_reference: RCD:A50..
database_cross_reference: RCD:A50z.
database_cross_reference: SNM:D-0478
database_cross_reference: SNMI:DE-31440
database_cross_reference: SNMI:DE-31441
database_cross_reference: SNOMEDCT_US:154344005
database_cross_reference: SNOMEDCT_US:186505008
database_cross_reference: SNOMEDCT_US:266193008
database_cross_reference: SNOMEDCT_US:47452006
database_cross_reference: SNOMEDCT_US:67924001

erythema infectiosum
type: Class
subclass of: viral infectious disease
PMOID: PMO:00029349
Subclass_of: viral infectious disease
Synonym: Disease;Fifth
Synonym: ERYTHEMA INFECTIOSUM
Synonym: Erythema Infectiosum
Synonym: Erythema Infectiosum (Fifth Disease)
Synonym: Erythema Infectiosum [Disease/Finding]
Synonym: Erythema contagiosum
Synonym: Erythema infectiosum
Synonym: Erythema infectiosum (disorder)
Synonym: Erythema infectiosum (fifth disease)
Synonym: Erythema infectiosum [fifth disease]
Tree Number: T10.7.2.3
database_cross_reference: CHV:0000015532
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:8743
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000588
database_cross_reference: ICD10:B08.3
database_cross_reference: ICD10AM:B08.3
database_cross_reference: ICD10CM:B08.3
database_cross_reference: ICD9CM:057.0
database_cross_reference: ICPC2P:A76002
database_cross_reference: ICPC2P:A76005
database_cross_reference: LCH_NW:sh2002000804
database_cross_reference: MDR:10015214
database_cross_reference: MDR:10015215
database_cross_reference: MDR:10016670
database_cross_reference: MDR:10034099
database_cross_reference: MEDCIN:31086
database_cross_reference: MEDCIN:312929
database_cross_reference: MEDLINEPLUS:1609
database_cross_reference: MSH:D016731
database_cross_reference: MTHICD9:057.0
database_cross_reference: NCI:C84695
database_cross_reference: NCI_NICHD:C84695
database_cross_reference: NDFRT:N0000003465
database_cross_reference: RCD:A570.
database_cross_reference: SNM:M-48420
database_cross_reference: SNMI:DE-39060
database_cross_reference: SNOMEDCT_US:154344005
database_cross_reference: SNOMEDCT_US:266193008
database_cross_reference: SNOMEDCT_US:34730008

contagious pustular dermatitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.
PMOID: PMO:00029454
Subclass_of: viral infectious disease
Synonym: Disease, Sixth
Synonym: EXANTHEM SUBITUM
Synonym: Ecthyma contagiosum
Synonym: Ecthyma, Contagious
Synonym: Exanthem subitum
Synonym: Exanthema Subitum
Synonym: Exanthema Subitum [Disease/Finding]
Synonym: Exanthema subitum
Synonym: Exanthema subitum (disorder)
Synonym: Exanthema subitum [sixth disease]
Tree Number: T10.7.2.83
database_cross_reference: CHV:0000004755
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:0050495
database_cross_reference: DO:DOID:8771
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000610
database_cross_reference: ICD10:B08.2
database_cross_reference: ICD10AM:B08.2
database_cross_reference: ICD10CM:B08.2
database_cross_reference: ICD10CM:B08.20
database_cross_reference: ICD9CM:058.1
database_cross_reference: ICD9CM:058.10
database_cross_reference: ICPC2P:A76007
database_cross_reference: MDR:10015586
database_cross_reference: MDR:10039222
database_cross_reference: MDR:10039223
database_cross_reference: MDR:10050048
database_cross_reference: MEDCIN:31312
database_cross_reference: MSH:D005077
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:058.1
database_cross_reference: MTHICD9:058.10
database_cross_reference: NDFRT:N0000001171
database_cross_reference: RCD:A57y1
database_cross_reference: SNM:D-0393
database_cross_reference: SNMI:DE-38060
database_cross_reference: SNOMEDCT_US:154343004
database_cross_reference: SNOMEDCT_US:154344005
database_cross_reference: SNOMEDCT_US:240559001
database_cross_reference: SNOMEDCT_US:266192003
database_cross_reference: SNOMEDCT_US:266193008
database_cross_reference: SNOMEDCT_US:402902002
database_cross_reference: SNOMEDCT_US:54385001

rubella
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.
PMOID: PMO:00029443
Subclass_of: viral infectious disease
Synonym: GERMAN MEASLES
Synonym: German Measles
Synonym: German measles
Synonym: Measle, Three Day
Synonym: Measles, German
Synonym: Measles, Three Day
Synonym: RUBELLA
Synonym: Rubella
Synonym: Rubella (disorder)
Synonym: Rubella Infection
Tree Number: T10.7.2.74
database_cross_reference: AOD:0000004825
database_cross_reference: AOD:0000023164
database_cross_reference: AOD:0000023166
database_cross_reference: CCPSS:0056455
database_cross_reference: CHV:0000010959
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:3100-2791
database_cross_reference: DO:DOID:8781
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001696
database_cross_reference: DXP:U003400
database_cross_reference: ICD10:B06
database_cross_reference: ICD10AM:B06
database_cross_reference: ICD10CM:B06
database_cross_reference: ICD10CM:B06.9
database_cross_reference: ICD9CM:056
database_cross_reference: ICPC2EENG:A74
database_cross_reference: ICPC2P:A74001
database_cross_reference: ICPC2P:A74003
database_cross_reference: LCH:U004168
database_cross_reference: LCH_NW:sh85115670
database_cross_reference: LNC:LA10502-5
database_cross_reference: MDR:10018206
database_cross_reference: MDR:10039252
database_cross_reference: MEDCIN:31182
database_cross_reference: MEDLINEPLUS:387
database_cross_reference: MSH:D012409
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85051
database_cross_reference: NCI_NICHD:C85051
database_cross_reference: NDFRT:N0000002655
database_cross_reference: PSY:20990
database_cross_reference: PSY:45000
database_cross_reference: RCD:A56..
database_cross_reference: SNM:D-0467
database_cross_reference: SNMI:DE-33410
database_cross_reference: SNOMEDCT_US:154343004
database_cross_reference: SNOMEDCT_US:266192003
database_cross_reference: SNOMEDCT_US:36653000

breast carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the breast.
PMOID: PMO:00027298
Subclass_of: in situ carcinoma
Synonym: Breast Ca in situ
Synonym: Breast Cancer Stage 0
Synonym: Breast Cancer in situ
Synonym: Breast Carcinoma In Situ
Synonym: Breast Carcinoma In Situ [Disease/Finding]
Synonym: Breast Carcinoma in situ
Synonym: Breast cancer in situ
Synonym: Ca in situ breast
Synonym: Carcinoma in situ of Breast
Synonym: Carcinoma in situ of breast
Tree Number: T10.2.2.3.17
database_cross_reference: CHV:0000017379
database_cross_reference: DO:DOID:8791
database_cross_reference: ICD10:D05
database_cross_reference: ICD10:D05.9
database_cross_reference: ICD10AM:D05
database_cross_reference: ICD10AM:D05.9
database_cross_reference: ICD10CM:D05
database_cross_reference: ICD10CM:D05.9
database_cross_reference: ICD9CM:233.0
database_cross_reference: MDR:10006189
database_cross_reference: MDR:10007358
database_cross_reference: MDR:10007361
database_cross_reference: MEDCIN:97956
database_cross_reference: MSH:D000071960
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3641
database_cross_reference: NCI_NCI-GLOSS:CDR0000044650
database_cross_reference: NCI_NCI-GLOSS:CDR0000438731
database_cross_reference: NDFRT:N0000192878
database_cross_reference: PDQ:CDR0000039644
database_cross_reference: RCD:B830.
database_cross_reference: SNOMEDCT_US:154636004
database_cross_reference: SNOMEDCT_US:189336000

eye carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: A carcinoma in situ that is characterized by the spread of cancer in the eye and the lack of invasion of surrounding tissues.
PMOID: PMO:00027286
Subclass_of: in situ carcinoma
Synonym: Ca in situ eye
Synonym: Cancer in situ of eye
Synonym: Carcinoma in situ of eye
Synonym: Carcinoma in situ of eye (disorder)
Synonym: Carcinoma in situ of eye, NOS
Synonym: Eye
Synonym: carcinoma in situ of eye
Synonym: carcinoma in situ of eye (diagnosis)
Synonym: carcinoma in situ of eyeball
Synonym: carcinoma in situ of eyeball (diagnosis)
Tree Number: T10.2.2.3.5
database_cross_reference: DO:DOID:8792
database_cross_reference: ICD10:D09.2
database_cross_reference: ICD10AM:D09.2
database_cross_reference: ICD10CM:D09.2
database_cross_reference: ICD9CM:234.0
database_cross_reference: MDR:10007368
database_cross_reference: MEDCIN:234930
database_cross_reference: MEDCIN:99805
database_cross_reference: MTH:U000753
database_cross_reference: RCD:B8y0.
database_cross_reference: SNMI:DA-F0802
database_cross_reference: SNOMEDCT_US:92590009

lung carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the lung.
PMOID: PMO:00027303
Subclass_of: in situ carcinoma
Synonym: Bronchus and lung
Synonym: Ca in situ bronchus/lung
Synonym: Ca-in-situ bronchus and lung
Synonym: Ca-in-situ bronchus/lung NOS
Synonym: Carcinoma in situ of bronchus and lung
Synonym: Carcinoma in situ of bronchus and lung (disorder)
Synonym: Carcinoma in situ of bronchus or lung NOS
Synonym: Carcinoma in situ of bronchus or lung NOS (disorder)
Tree Number: T10.2.2.3.18
database_cross_reference: DO:DOID:8800
database_cross_reference: ICD10:D02.2
database_cross_reference: ICD10AM:D02.2
database_cross_reference: ICD10CM:D02.2
database_cross_reference: ICD9CM:231.2
database_cross_reference: MDR:10007362
database_cross_reference: MTH:U000742
database_cross_reference: RCD:B812.
database_cross_reference: RCD:B812z
database_cross_reference: SNOMEDCT_US:189262006
database_cross_reference: SNOMEDCT_US:189268005

trachea carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the trachea.
PMOID: PMO:00027283
Subclass_of: in situ carcinoma
Synonym: Ca in situ trachea
Synonym: Carcinoma in situ of Trachea
Synonym: Carcinoma in situ of the Trachea
Synonym: Carcinoma in situ of trachea
Synonym: Carcinoma in situ of trachea (disorder)
Synonym: Carcinoma in situ of trachea, NOS
Synonym: Severe Epithelial Dysplasia of Trachea
Synonym: Severe epith dysplas trachea
Synonym: Severe epithelial dysplasia of trachea
Synonym: Trachea
Tree Number: T10.2.2.3.2
database_cross_reference: DO:DOID:8802
database_cross_reference: ICD10:D02.1
database_cross_reference: ICD10AM:D02.1
database_cross_reference: ICD10CM:D02.1
database_cross_reference: ICD9CM:231.1
database_cross_reference: MDR:10007401
database_cross_reference: MDR:10044286
database_cross_reference: MEDCIN:97314
database_cross_reference: MTH:U000697
database_cross_reference: NCI:C3639
database_cross_reference: RCD:B811.
database_cross_reference: SNMI:D2-F0702
database_cross_reference: SNOMEDCT_US:92772005

heterophyiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Metagonimus yokogawai. The symptoms are diarrhea and colicky abdominal pain. The heart and brain can also be infected.
PMOID: PMO:00029638
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Echinochasmus
Synonym: Infection by Metagonimus yokogawai
Synonym: Watsoniasis
Synonym: echinostomiasis
Synonym: heterophyes infectious disease
Synonym: metagonimiasis
Tree Number: T10.7.4.1.16
database_cross_reference: DO:DOID:1218
database_cross_reference: DO:DOID:882
database_cross_reference: DO:DOID:884
database_cross_reference: ICD10CM:B66.8

colon carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the colon.
PMOID: PMO:00027309
Subclass_of: in situ carcinoma
Synonym: COLON NOS CANCER IN SITU
Synonym: Ca in situ colon
Synonym: Cancer in situ of colon
Synonym: Carcinoma in situ of Colon
Synonym: Carcinoma in situ of colon
Synonym: Carcinoma in situ of colon (disorder)
Synonym: Carcinoma in situ of colon NOS
Synonym: Carcinoma in situ of colon NOS (disorder)
Synonym: Carcinoma in situ of colon, NOS
Synonym: Carcinoma in situ of the Colon
Tree Number: T10.2.2.3.24
database_cross_reference: CCPSS:0059516
database_cross_reference: DO:DOID:8826
database_cross_reference: ICD10:D01.0
database_cross_reference: ICD10AM:D01.0
database_cross_reference: ICD10CM:D01.0
database_cross_reference: ICD9CM:230.3
database_cross_reference: MDR:10007365
database_cross_reference: MDR:10009964
database_cross_reference: MDR:10009992
database_cross_reference: MDR:10063523
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3638
database_cross_reference: PDQ:CDR0000042420
database_cross_reference: RCD:B803.
database_cross_reference: RCD:B803z
database_cross_reference: SNMI:D5-F1312
database_cross_reference: SNOMEDCT_US:189230008
database_cross_reference: SNOMEDCT_US:92568009

parasitic helminthiasis infectious disease
type: Class
subclass of: parasitic infectious disease
definition: A parasitic infectious disease that occurs when part of the body is infested with parasitic worms such as cestodes, nematodes and trematodes.
PMOID: PMO:00029617
Subclass_of: parasitic infectious disease
Synonym: helminth infection
Synonym: helminthiasis
Synonym: helminthosis
Synonym: worm infection
Tree Number: T10.7.4.1
database_cross_reference: DO:DOID:883

metagonimiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Metagonimus yokogawai. The symptoms are diarrhea and colicky abdominal pain. The heart and brain can also be infected.
PMOID: PMO:00029640
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Echinochasmus
Synonym: Infection by Metagonimus yokogawai
Synonym: Watsoniasis
Synonym: echinostomiasis
Synonym: heterophyes infectious disease
Synonym: heterophyiasis
Tree Number: T10.7.4.1.18
database_cross_reference: DO:DOID:1218
database_cross_reference: DO:DOID:882
database_cross_reference: DO:DOID:884
database_cross_reference: ICD10CM:B66.8

fascioliasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.
PMOID: PMO:00029621
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Fasciola hepatica infection
Synonym: Infection by Fasciola
Synonym: Liver flukes
Synonym: Sheep liver fluke infection
Tree Number: T10.7.4.1.4
database_cross_reference: DO:DOID:885

actinic keratosis
type: Class
subclass of: pre-malignant neoplasm
PMOID: PMO:00027279
Subclass_of: pre-malignant neoplasm
Synonym: ACTINIC KERATOSIS
Synonym: AK - Actinic keratosis
Synonym: Actinic (Solar) Keratosis
Synonym: Actinic Keratoses
Synonym: Actinic Keratosis
Synonym: Actinic keratoses
Synonym: Actinic keratosis
Synonym: Actinic keratosis (disorder)
Synonym: Actinic keratosis (morphologic abnormality)
Synonym: Atrophic keratosis
Tree Number: T10.2.2.1
database_cross_reference: CCPSS:0062969
database_cross_reference: CHV:0000007068
database_cross_reference: COSTAR:024
database_cross_reference: DO:DOID:8866
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000966
database_cross_reference: HPO:HP:0025127
database_cross_reference: ICD10:L57.0
database_cross_reference: ICD10AM:L57.0
database_cross_reference: ICD10CM:L57.0
database_cross_reference: ICD9CM:702.0
database_cross_reference: ICPC2P:S21007
database_cross_reference: ICPC2P:S21012
database_cross_reference: ICPC2P:S80011
database_cross_reference: ICPC2P:S80012
database_cross_reference: ICPC2P:S80013
database_cross_reference: MDR:10000614
database_cross_reference: MDR:10039979
database_cross_reference: MDR:10039980
database_cross_reference: MDR:10041304
database_cross_reference: MEDCIN:33088
database_cross_reference: MEDLINEPLUS:1419
database_cross_reference: MEDLINEPLUS:405
database_cross_reference: MSH:D055623
database_cross_reference: MTH:U003215
database_cross_reference: NCI:C3148
database_cross_reference: NCI_NCI-GLOSS:CDR0000044479
database_cross_reference: NCI_NCI-GLOSS:CDR0000044480
database_cross_reference: NCI_NCI-GLOSS:CDR0000045133
database_cross_reference: NDFRT:N0000181025
database_cross_reference: OMIM:MTHU025673
database_cross_reference: PDQ:CDR0000038788
database_cross_reference: RCD:M222.
database_cross_reference: RCD:M226.
database_cross_reference: SNM:M-72850
database_cross_reference: SNMI:M-72850
database_cross_reference: SNOMEDCT_US:156395005
database_cross_reference: SNOMEDCT_US:156398007
database_cross_reference: SNOMEDCT_US:156400006
database_cross_reference: SNOMEDCT_US:201096007
database_cross_reference: SNOMEDCT_US:201097003
database_cross_reference: SNOMEDCT_US:201098008
database_cross_reference: SNOMEDCT_US:201101007
database_cross_reference: SNOMEDCT_US:201106002
database_cross_reference: SNOMEDCT_US:201107006
database_cross_reference: SNOMEDCT_US:267858008
database_cross_reference: SNOMEDCT_US:267860005
database_cross_reference: SNOMEDCT_US:46795000
database_cross_reference: SNOMEDCT_US:856006

molluscum contagiosum
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.
PMOID: PMO:00029412
Subclass_of: viral infectious disease
Tree Number: T10.7.2.49
database_cross_reference: DO:DOID:8867

penis carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the penis.
PMOID: PMO:00027284
Subclass_of: in situ carcinoma
Synonym: Bowen Disease of the Penis
Synonym: Bowen disease of penis
Synonym: Bowen's Disease of Penis
Synonym: Bowen's Disease of the Penis
Synonym: Bowen's disease of glans penis
Synonym: Bowen's disease of penis
Synonym: Bowen's disease of penis (diagnosis)
Synonym: Bowen's disease of penis (disorder)
Synonym: Bowens disease of penis
Synonym: CIS - Carc in situ of penis
Tree Number: T10.2.2.3.3
database_cross_reference: CHV:0000021388
database_cross_reference: DO:DOID:8872
database_cross_reference: DXP:U000595
database_cross_reference: ICD10:D07.4
database_cross_reference: ICD10AM:D07.4
database_cross_reference: ICD10AM:M8080/2
database_cross_reference: ICD10CM:D00-D09
database_cross_reference: ICD10CM:D07.4
database_cross_reference: ICD9CM:233.5
database_cross_reference: MDR:10007384
database_cross_reference: MDR:10034328
database_cross_reference: MDR:10037732
database_cross_reference: MEDCIN:233440
database_cross_reference: MEDCIN:233446
database_cross_reference: MEDCIN:355076
database_cross_reference: MEDCIN:97979
database_cross_reference: MTH:U000725
database_cross_reference: NCI:C27790
database_cross_reference: NCI_NCI-GLOSS:CDR0000482355
database_cross_reference: RCD:B835.
database_cross_reference: RCD:BB2K.
database_cross_reference: RCD:X78il
database_cross_reference: RCDSY:BB2K.
database_cross_reference: SNM:M-8080/2
database_cross_reference: SNMI:D7-F0312
database_cross_reference: SNMI:M-80802
database_cross_reference: SNOMEDCT_US:18348002
database_cross_reference: SNOMEDCT_US:189208007
database_cross_reference: SNOMEDCT_US:255104003
database_cross_reference: SNOMEDCT_US:255105002
database_cross_reference: SNOMEDCT_US:255147003
database_cross_reference: SNOMEDCT_US:398768004
database_cross_reference: SNOMEDCT_US:398831006
database_cross_reference: SNOMEDCT_US:400092004
database_cross_reference: SNOMEDCT_US:92679008

fasciolopsiasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Fasciolopsis buski. The symptoms include diarrhea, abdominal pain, fever, ascites, anasarca and intestinal obstruction.
PMOID: PMO:00029670
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Fasciolopsis buski
Synonym: Infectious Disease by Fasciolopsis
Tree Number: T10.7.4.1.35
database_cross_reference: DO:DOID:888

rosacea
type: Class
subclass of: skin disease
PMOID: PMO:00033892
Subclass_of: skin disease
Synonym: ACNE ROSACEA
Synonym: Acne Rosacea
Synonym: Acne erythematosa
Synonym: Acne rosacea
Synonym: Acne rosacea (disorder)
Synonym: Acne roscea
Synonym: Acne, erythematosa
Synonym: Acne, rosacea
Synonym: Acne;rosacea
Synonym: ROSACEA
Tree Number: T10.8.12.2.25
database_cross_reference: BI:BI00623
database_cross_reference: CHV:0000010944
database_cross_reference: COSTAR:658
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:ACNE
database_cross_reference: DO:DOID:8881
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001692
database_cross_reference: HPO:HP:0001041
database_cross_reference: ICD10:L71
database_cross_reference: ICD10:L71.9
database_cross_reference: ICD10AM:L71
database_cross_reference: ICD10AM:L71.9
database_cross_reference: ICD10CM:L71
database_cross_reference: ICD10CM:L71.9
database_cross_reference: ICD9CM:695.3
database_cross_reference: ICPC2P:S99001
database_cross_reference: LCH:U004164
database_cross_reference: LCH_NW:sh85115399
database_cross_reference: MDR:10000514
database_cross_reference: MDR:10039218
database_cross_reference: MDR:10039219
database_cross_reference: MEDCIN:33127
database_cross_reference: MEDLINEPLUS:1247
database_cross_reference: MSH:D012393
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:695.3
database_cross_reference: NCI:C97136
database_cross_reference: NCI_NICHD:C97136
database_cross_reference: NDFRT:N0000002653
database_cross_reference: RCD:M153.
database_cross_reference: RCD:M153z
database_cross_reference: SNM:M-46620
database_cross_reference: SNMI:D0-51150
database_cross_reference: SNOMEDCT_US:156364003
database_cross_reference: SNOMEDCT_US:1612004
database_cross_reference: SNOMEDCT_US:200930009
database_cross_reference: SNOMEDCT_US:200935004
database_cross_reference: SNOMEDCT_US:267849001
database_cross_reference: SNOMEDCT_US:398909004

psoriasis
type: Class
subclass of: skin disease
PMOID: PMO:00033880
Subclass_of: skin disease
Synonym: PSORIASIS
Synonym: Psoriases
Synonym: Psoriasis
Synonym: Psoriasis (disorder)
Synonym: Psoriasis NOS
Synonym: Psoriasis NOS (disorder)
Synonym: Psoriasis [Disease/Finding]
Synonym: Psoriasis unspecified
Synonym: Psoriasis unspecified (disorder)
Synonym: Psoriasis, NOS
Tree Number: T10.8.12.2.17
database_cross_reference: AOD:0000005222
database_cross_reference: BI:BI00608
database_cross_reference: CCPSS:0043208
database_cross_reference: CHV:0000010310
database_cross_reference: COSTAR:623
database_cross_reference: CSP:1849-8073
database_cross_reference: CST:PSORIASIS
database_cross_reference: DO:DOID:8893
database_cross_reference: DXP:U001612
database_cross_reference: DXP:U003255
database_cross_reference: HPO:HP:0003765
database_cross_reference: ICD10:L40
database_cross_reference: ICD10:L40.9
database_cross_reference: ICD10AM:L40
database_cross_reference: ICD10AM:L40.9
database_cross_reference: ICD10CM:L40
database_cross_reference: ICD10CM:L40.9
database_cross_reference: ICPC2EENG:S91
database_cross_reference: ICPC2P:S91001
database_cross_reference: LCH:U003898
database_cross_reference: LCH_NW:sh85108334
database_cross_reference: LNC:LA15165-6
database_cross_reference: MDR:10037153
database_cross_reference: MEDCIN:33107
database_cross_reference: MEDLINEPLUS:373
database_cross_reference: MSH:D011565
database_cross_reference: NCI:C3346
database_cross_reference: NCI_NCI-GLOSS:CDR0000044219
database_cross_reference: NCI_NICHD:C3346
database_cross_reference: NDFRT:N0000002526
database_cross_reference: OMIM:MTHU036411
database_cross_reference: RCD:M1610
database_cross_reference: RCD:M161z
database_cross_reference: RCD:X506Y
database_cross_reference: SNM:M-48840
database_cross_reference: SNMI:D0-22100
database_cross_reference: SNOMEDCT_US:156369008
database_cross_reference: SNOMEDCT_US:156371008
database_cross_reference: SNOMEDCT_US:200961000
database_cross_reference: SNOMEDCT_US:200978009
database_cross_reference: SNOMEDCT_US:267851002
database_cross_reference: SNOMEDCT_US:9014002

tinea nigra
type: Class
subclass of: superficial mycosis
definition: A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.
PMOID: PMO:00029286
Subclass_of: superficial mycosis
Synonym: Infection by Cladosporium werneckii
Synonym: Infection by Cladosporium werneckii (disorder)
Synonym: Infection caused by Cladosporium werneckii
Synonym: Infection caused by Cladosporium werneckii (disorder)
Synonym: Keratomycosis nigricans
Synonym: Keratomycosis nigricans palmaris
Synonym: Microsporosis nigra
Synonym: Microsporosis nigra (disorder)
Synonym: Nigra: [tinea] or [keratomycosis]
Synonym: Nigra: [tinea] or [keratomycosis] (disorder)
Tree Number: T10.7.1.1.1
database_cross_reference: DO:DOID:8912
database_cross_reference: ICD10:B36.1
database_cross_reference: ICD10AM:B36.1
database_cross_reference: ICD10CM:B36.1
database_cross_reference: ICD9CM:111.1
database_cross_reference: MDR:10043871
database_cross_reference: MEDCIN:97637
database_cross_reference: MTHICD9:111.1
database_cross_reference: RCD:XE0SF
database_cross_reference: SNM:D-0582
database_cross_reference: SNMI:DE-45600
database_cross_reference: SNOMEDCT_US:1022006
database_cross_reference: SNOMEDCT_US:183342005
database_cross_reference: SNOMEDCT_US:184346000
database_cross_reference: SNOMEDCT_US:185367005
database_cross_reference: SNOMEDCT_US:186289000
database_cross_reference: SNOMEDCT_US:187000000
database_cross_reference: SNOMEDCT_US:266153005

dermatophytosis
type: Class
subclass of: cutaneous mycosis
definition: A cutaneous mycosis that results_in fungal infection located_in skin, located_in hair, and located_in nail, has_material_basis_in Epidermophyton, has_material_basis_in Microsporum, or has_material_basis_in Trichophyton, which invade the dead keratin and has_symptom itchy patches, and has_symptom red rash on the skin.
PMOID: PMO:00029294
Subclass_of: cutaneous mycosis
Synonym: Dermatophytoses
Synonym: Dermatophytosis
Synonym: Dermatophytosis-tinea/ringworm
Synonym: Microsporic tinea
Synonym: Microsporic tinea NOS
Synonym: Microsporic tinea, NOS
Synonym: Ringworm
Synonym: Ringworm NOS
Synonym: Ringworm, NOS
Synonym: TINEA
Tree Number: T10.7.1.2.2
database_cross_reference: AOD:0000023181
database_cross_reference: BI:BI00616
database_cross_reference: CCPSS:0006114
database_cross_reference: CCPSS:0036041
database_cross_reference: CHV:0000012299
database_cross_reference: CHV:0000047059
database_cross_reference: COSTAR:736
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1988-5318
database_cross_reference: DO:DOID:12404
database_cross_reference: ICD10CM:B35.9
database_cross_reference: ICPC2P:S74008
database_cross_reference: ICPC2P:S74009
database_cross_reference: LCH_NW:sh85114145
database_cross_reference: MDR:10039184
database_cross_reference: MDR:10043864
database_cross_reference: MDR:10043869
database_cross_reference: MDR:10043870
database_cross_reference: MDR:10043872
database_cross_reference: MDR:10060889
database_cross_reference: MEDLINEPLUS:1228
database_cross_reference: MSH:D014005
database_cross_reference: MTH:737
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:110.9
database_cross_reference: NCI:C112181
database_cross_reference: NCI_NICHD:C112181
database_cross_reference: NDFRT:N0000002955
database_cross_reference: RCD:XE0S9
database_cross_reference: SNM:D-0575
database_cross_reference: SNMI:DE-45000
database_cross_reference: SNOMEDCT_US:154394006
database_cross_reference: SNOMEDCT_US:186984003
database_cross_reference: SNOMEDCT_US:266214005
database_cross_reference: SNOMEDCT_US:47382004

learning disability
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.
PMOID: PMO:00027989
Subclass_of: specific developmental disorder
Synonym: Academic skill disorder
Synonym: Academic skill disorder, NOS
Synonym: Disorder;academic skills
Synonym: Disorder;learning
Synonym: LEARNING DIS
Synonym: Learning Disorder
Synonym: Learning Disorders
Synonym: Learning Disorders [Disease/Finding]
Synonym: Learning differences
Synonym: Learning disorder
Tree Number: T10.3.5.1.5
database_cross_reference: AOD:0000023655
database_cross_reference: CHV:0000007261
database_cross_reference: CSP:2483-6402
database_cross_reference: DO:DOID:8927
database_cross_reference: ICD10CM:F81.9
database_cross_reference: ICPC2P:P24002
database_cross_reference: ICPC2P:P24007
database_cross_reference: MDR:10024093
database_cross_reference: MDR:10024094
database_cross_reference: MDR:10061265
database_cross_reference: MEDLINEPLUS:306
database_cross_reference: MSH:D007859
database_cross_reference: MTHICD9:315.9
database_cross_reference: NCI:C89334
database_cross_reference: NCI_NICHD:C89334
database_cross_reference: NDFRT:N0000001792
database_cross_reference: PSY:27990
database_cross_reference: SNMI:D9-18210
database_cross_reference: SNOMEDCT_US:1855002

Wilson disease
type: Class
subclass of: metal metabolism disorder
PMOID: PMO:00029031
Subclass_of: metal metabolism disorder
Synonym: Cerebral Pseudoscleroses
Synonym: Cerebral Pseudosclerosis
Synonym: Cerebral pseudosclerosis
Synonym: Cerebral pseudosclerosis (disorder)
Synonym: Copper Storage Disease
Synonym: Copper storage disease
Synonym: Degeneration, Hepatocerebral
Synonym: Degeneration, Hepatolenticular
Synonym: Degeneration, Neurohepatic
Synonym: Degeneration, Progressive Lenticular
Tree Number: T10.6.2.4.9
database_cross_reference: AOD:0000005764
database_cross_reference: AOD:0000023451
database_cross_reference: CCPSS:0034808
database_cross_reference: CHV:0000006060
database_cross_reference: CSP:1849-4349
database_cross_reference: DO:DOID:893
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002026
database_cross_reference: ICD10CM:E83.01
database_cross_reference: ICPC2P:T99046
database_cross_reference: LCH:U002175
database_cross_reference: LCH_NW:sh85060301
database_cross_reference: MDR:10019819
database_cross_reference: MDR:10047988
database_cross_reference: MEDCIN:31995
database_cross_reference: MEDLINEPLUS:1691
database_cross_reference: MSH:D006527
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:275.1
database_cross_reference: NCI:C84756
database_cross_reference: NDFRT:N0000001510
database_cross_reference: OMIM:277900
database_cross_reference: OMIM:606882
database_cross_reference: RCD:C3510
database_cross_reference: SNM:D-8725
database_cross_reference: SNMI:D6-32310
database_cross_reference: SNOMEDCT_US:154751003
database_cross_reference: SNOMEDCT_US:190823004
database_cross_reference: SNOMEDCT_US:191710006
database_cross_reference: SNOMEDCT_US:192640001
database_cross_reference: SNOMEDCT_US:267504005
database_cross_reference: SNOMEDCT_US:88518009

plantar fascial fibromatosis
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032275
Subclass_of: connective tissue disease
Synonym: Dupuytren disease of foot
Synonym: Dupuytren's contract of foot
Synonym: Dupuytren's contracture of foot
Synonym: Dupuytren's contracture of foot (disorder)
Synonym: Fibromatosis, Plantar
Synonym: Fibromatosis, Plantar [Disease/Finding]
Synonym: Ledderhose Disease
Synonym: Ledderhose disease
Synonym: Ledderhose's Disease
Synonym: Ledderhose's disease
Tree Number: T10.8.4.1.8
database_cross_reference: CHV:0000017638
database_cross_reference: CHV:0000032034
database_cross_reference: DO:DOID:8936
database_cross_reference: ICD10:M72.2
database_cross_reference: ICD10AM:M72.2
database_cross_reference: ICD10CM:M72.2
database_cross_reference: ICD9CM:728.71
database_cross_reference: MDR:10035154
database_cross_reference: MDR:10071740
database_cross_reference: MEDCIN:34465
database_cross_reference: MSH:D000071380
database_cross_reference: NCI:C4680
database_cross_reference: NDFRT:N0000192879
database_cross_reference: OMIM:MTHU036681
database_cross_reference: RCD:N2179
database_cross_reference: RCD:X707Z
database_cross_reference: SNM:D-3353
database_cross_reference: SNM:M-76100
database_cross_reference: SNMI:D1-50440
database_cross_reference: SNOMEDCT_US:13370002
database_cross_reference: SNOMEDCT_US:202882003
database_cross_reference: SNOMEDCT_US:240032001

cowpox
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face.
PMOID: PMO:00029430
Subclass_of: viral infectious disease
Synonym: COWPOX
Synonym: Cow Pox
Synonym: Cow pox
Synonym: Cowpox
Synonym: Cowpox (disorder)
Synonym: Cowpox [Disease/Finding]
Synonym: Pox, Cow
Synonym: cow pox
Synonym: cowpox (diagnosis)
Synonym: yaba
Tree Number: T10.7.2.64
database_cross_reference: CHV:0000003416
database_cross_reference: CSP:3100-0734
database_cross_reference: DO:DOID:8956
database_cross_reference: DXP:U000412
database_cross_reference: ICD10CM:B08.010
database_cross_reference: ICD9CM:051.01
database_cross_reference: ICPC2P:A76001
database_cross_reference: ICPC2P:A77024
database_cross_reference: MDR:10011238
database_cross_reference: MDR:10011242
database_cross_reference: MEDCIN:31408
database_cross_reference: MSH:D015605
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003293
database_cross_reference: RCD:A510.
database_cross_reference: SNM:D-0377
database_cross_reference: SNMI:DE-31430
database_cross_reference: SNOMEDCT_US:154344005
database_cross_reference: SNOMEDCT_US:266193008
database_cross_reference: SNOMEDCT_US:70090004

metal metabolism disorder
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that involves metabolic disturbances in the processing or distribution of dietary minerals.
PMOID: PMO:00029000
Subclass_of: inherited metabolic disorder
Synonym: METAL METAB INBORN ERR
Synonym: METAL METAB INBORN ERRORS
Synonym: Metal Metabolism, Inborn Error
Synonym: Metal Metabolism, Inborn Errors
Synonym: Metal Metabolism, Inborn Errors [Disease/Finding]
Synonym: inborn metal metabolism disorder
Tree Number: T10.6.2.4
database_cross_reference: CSP:4000-0215
database_cross_reference: DO:DOID:896
database_cross_reference: MSH:D008664
database_cross_reference: NDFRT:N0000002006

subacute sclerosing panencephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection located_in brain, has_material_basis_in Measles virus which is immune resistant (which can be a result of a mutation of the virus itself).
PMOID: PMO:00029363
Subclass_of: viral infectious disease
Synonym: DEMENTIA, DECEREBRATE
Synonym: Dawson's encephalitis
Synonym: Dawson's inclusion body encephalitis
Synonym: ENCEPH INCLUSION BODY MEASLES
Synonym: Encephaltis, Inclusion Body, Measles
Synonym: INCLUSION BODY ENCEPH MEASLES
Synonym: Immunosuppressive measles encephalitis
Synonym: Inclusion Body Encephalitis, Measles
Synonym: LEUKOENCEPH SUBACUTE SCLEROSING
Synonym: LEUKOENCEPH VAN BOGAERTS
Tree Number: T10.7.2.16
database_cross_reference: CHV:0000011800
database_cross_reference: CSP:2042-2360
database_cross_reference: DO:DOID:8970
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001404
database_cross_reference: ICD10:A81.1
database_cross_reference: ICD10AM:A81.1
database_cross_reference: ICD10CM:A81.1
database_cross_reference: ICD9CM:046.2
database_cross_reference: LCH:U004505
database_cross_reference: LCH_NW:sh86002656
database_cross_reference: MDR:10042297
database_cross_reference: MEDCIN:31360
database_cross_reference: MSH:D013344
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:046.2
database_cross_reference: NCI:C85171
database_cross_reference: NCI_NICHD:C85171
database_cross_reference: NDFRT:N0000002845
database_cross_reference: OMIM:260470
database_cross_reference: RCD:F0301
database_cross_reference: SNM:D-0483
database_cross_reference: SNMI:DE-33960
database_cross_reference: SNOMEDCT_US:186484007
database_cross_reference: SNOMEDCT_US:192685000
database_cross_reference: SNOMEDCT_US:359686005
database_cross_reference: SNOMEDCT_US:416154000
database_cross_reference: SNOMEDCT_US:84196008

narcolepsy
type: Class
subclass of: sleep disorder
definition: A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.
PMOID: PMO:00027892
Subclass_of: sleep disorder
Synonym: GELINEAU SYNDROME
Synonym: Gelineau Syndrome
Synonym: Gelineau's Syndrome
Synonym: Gelineau's Syndromes
Synonym: Gelineau's syndrome
Synonym: Gelineaus Syndrome
Synonym: NARCOLEPSY
Synonym: Narcolepsy
Synonym: Narcolepsy (disorder)
Synonym: Narcolepsy NOS
Tree Number: T10.3.1.4
database_cross_reference: BI:BI00550
database_cross_reference: CCPSS:0042859
database_cross_reference: CHV:0000008486
database_cross_reference: COSTAR:U000463
database_cross_reference: CSP:2056-7716
database_cross_reference: CST:SOMNOLENCE
database_cross_reference: DO:DOID:8986
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001254
database_cross_reference: HPO:HP:0030050
database_cross_reference: ICD10CM:G47.41
database_cross_reference: ICD10CM:G47.419
database_cross_reference: ICD9CM:347.0
database_cross_reference: ICPC2P:N99013
database_cross_reference: LCH:U003122
database_cross_reference: LCH_NW:sh85089801
database_cross_reference: MDR:10028713
database_cross_reference: MEDCIN:33710
database_cross_reference: MEDLINEPLUS:408
database_cross_reference: MSH:D009290
database_cross_reference: MTHICD9:347.00
database_cross_reference: NCI:C84489
database_cross_reference: NDFRT:N0000002108
database_cross_reference: OMIM:MTHU039740
database_cross_reference: PSY:32990
database_cross_reference: PSY:36773
database_cross_reference: RCD:F271.
database_cross_reference: SNM:F-85940
database_cross_reference: SNMI:D9-74250
database_cross_reference: SNOMEDCT_US:155059003
database_cross_reference: SNOMEDCT_US:267702006
database_cross_reference: SNOMEDCT_US:60380001

cervix uteri carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the uterine cervix.
PMOID: PMO:00027312
Subclass_of: in situ carcinoma
Synonym: CARCINOMA CERVIX IN SITU
Synonym: CARCINOMA UTERINE CERVIX IN SITU
Synonym: CERVICAL CANCER CIN III
Synonym: CERVICAL CARCINOMA IN SITU
Synonym: CERVICAL INTRAEPITHELIAL NEOPL GRADE III
Synonym: CERVIX CARCINOMA IN SITU
Synonym: CIN 3
Synonym: CIN 3 - Cervical intraepithelial neoplasia grade 3
Synonym: CIN 3 AJCC v6
Synonym: CIN 3-Cerv intraep neop 3
Tree Number: T10.2.2.3.27
database_cross_reference: CCPSS:1002185
database_cross_reference: CHV:0000021036
database_cross_reference: CHV:0000050004
database_cross_reference: CHV:0000050006
database_cross_reference: COSTAR:U000159
database_cross_reference: CST:CARCINOMA CERVIX SITU
database_cross_reference: DO:DOID:8991
database_cross_reference: ICD10:D06
database_cross_reference: ICD10:D06.9
database_cross_reference: ICD10AM:D06
database_cross_reference: ICD10AM:D06.9
database_cross_reference: ICD10CM:D06
database_cross_reference: ICD10CM:D06.9
database_cross_reference: ICD9CM:233.1
database_cross_reference: ICPC2P:X75007
database_cross_reference: ICPC2P:X75013
database_cross_reference: ICPC2P:X75014
database_cross_reference: ICPC2P:X75016
database_cross_reference: MDR:10007324
database_cross_reference: MDR:10007363
database_cross_reference: MDR:10007364
database_cross_reference: MDR:10007494
database_cross_reference: MDR:10008232
database_cross_reference: MDR:10008237
database_cross_reference: MDR:10008343
database_cross_reference: MDR:10009215
database_cross_reference: MDR:10021571
database_cross_reference: MDR:10046771
database_cross_reference: MDR:10049702
database_cross_reference: MDR:10059383
database_cross_reference: MDR:10061809
database_cross_reference: MEDCIN:312329
database_cross_reference: MEDCIN:356499
database_cross_reference: MEDCIN:97976
database_cross_reference: MEDCIN:97977
database_cross_reference: MSH:D018290
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:233.1
database_cross_reference: NCI:C4000
database_cross_reference: PDQ:CDR0000037981
database_cross_reference: PDQ:CDR0000321379
database_cross_reference: RCD:X77n4
database_cross_reference: RCD:X78Xj
database_cross_reference: RCD:XE1wH
database_cross_reference: SNMI:D7-F0562
database_cross_reference: SNMI:M-80772
database_cross_reference: SNOMEDCT_US:145597000
database_cross_reference: SNOMEDCT_US:154637008
database_cross_reference: SNOMEDCT_US:168405008
database_cross_reference: SNOMEDCT_US:189339007
database_cross_reference: SNOMEDCT_US:20365006
database_cross_reference: SNOMEDCT_US:22725004
database_cross_reference: SNOMEDCT_US:252990005
database_cross_reference: SNOMEDCT_US:252991009
database_cross_reference: SNOMEDCT_US:254889004
database_cross_reference: SNOMEDCT_US:269491003
database_cross_reference: SNOMEDCT_US:269649008
database_cross_reference: SNOMEDCT_US:92564006

sudden infant death syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.
PMOID: PMO:00025136
Subclass_of: syndrome
Synonym: COT death
Synonym: Cot Death
Synonym: Cot Deaths
Synonym: Cot death
Synonym: Cot death (event)
Synonym: Crib Death
Synonym: Crib death
Synonym: DEATH INFANT SUDDEN
Synonym: DEATH SUDDEN INFANT
Synonym: Death infant sudden
Tree Number: T10.1.21
database_cross_reference: AOD:0000005274
database_cross_reference: AOD:0000023313
database_cross_reference: AOD:0000023314
database_cross_reference: AOD:0000023316
database_cross_reference: CCPSS:0023375
database_cross_reference: CHV:0000011838
database_cross_reference: CSP:0635-4620
database_cross_reference: CST:SIDS
database_cross_reference: DO:DOID:9007
database_cross_reference: ICD10:R95
database_cross_reference: ICD10AM:R95
database_cross_reference: ICD9CM:798.0
database_cross_reference: LCH:U006196
database_cross_reference: LCH_NW:sh85129616
database_cross_reference: LNC:LA10530-6
database_cross_reference: MDR:10011220
database_cross_reference: MDR:10011910
database_cross_reference: MDR:10011939
database_cross_reference: MDR:10021733
database_cross_reference: MDR:10040666
database_cross_reference: MDR:10040667
database_cross_reference: MDR:10042439
database_cross_reference: MDR:10042440
database_cross_reference: MDR:10069606
database_cross_reference: MEDCIN:34820
database_cross_reference: MEDLINEPLUS:504
database_cross_reference: MSH:D013398
database_cross_reference: MTH:U003367
database_cross_reference: MTHICD9:798.0
database_cross_reference: NCI:C85173
database_cross_reference: NCI_NCI-GLOSS:CDR0000439426
database_cross_reference: NCI_NCI-GLOSS:CDR0000439427
database_cross_reference: NCI_NCI-GLOSS:CDR0000439428
database_cross_reference: NCI_NICHD:C85173
database_cross_reference: NDFRT:N0000002856
database_cross_reference: OMIM:272120
database_cross_reference: OMIM:516000
database_cross_reference: OMIM:590050
database_cross_reference: OMIM:600163
database_cross_reference: PSY:12425
database_cross_reference: PSY:50587
database_cross_reference: RCD:R210.
database_cross_reference: RCD:R2100
database_cross_reference: RCD:R2101
database_cross_reference: RCD:R210z
database_cross_reference: RCD:XM09S
database_cross_reference: RCDSY:R210.
database_cross_reference: RCDSY:R2100
database_cross_reference: RCDSY:R2101
database_cross_reference: RCDSY:R210z
database_cross_reference: SNM:F-Y1840
database_cross_reference: SNMI:DF-D0024
database_cross_reference: SNOMEDCT_US:158718001
database_cross_reference: SNOMEDCT_US:207534005
database_cross_reference: SNOMEDCT_US:207535006
database_cross_reference: SNOMEDCT_US:207536007
database_cross_reference: SNOMEDCT_US:207538008
database_cross_reference: SNOMEDCT_US:207671002
database_cross_reference: SNOMEDCT_US:51178009

psoriatic arthritis
type: Class
subclass of: syndrome
definition: A syndrome that occurs in humans with psoriasis who also experience symptoms similar to arthritis.
PMOID: PMO:00025159
Subclass_of: syndrome
Synonym: ARTHRITIS PSORIATIC
Synonym: ARTHRITIS, PSORIATIC
Synonym: Arthritic Psoriasis
Synonym: Arthritis Psoriatica
Synonym: Arthritis, Psoriatic
Synonym: Arthritis, Psoriatic [Disease/Finding]
Synonym: Arthritis, psoriatic
Synonym: Arthritis;psoriatic
Synonym: Arthropathic psoriasis
Synonym: Arthropathic psoriasis, unspecified
Tree Number: T10.1.40
database_cross_reference: CCPSS:0054282
database_cross_reference: CHV:0000001470
database_cross_reference: COSTAR:624
database_cross_reference: CSP:5006-0031
database_cross_reference: DO:DOID:9008
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000157
database_cross_reference: ICD10:L40.5
database_cross_reference: ICD10AM:L40.5
database_cross_reference: ICD10CM:L40.5
database_cross_reference: ICD10CM:L40.50
database_cross_reference: ICD9CM:696.0
database_cross_reference: ICPC2P:S91002
database_cross_reference: ICPC2P:S91003
database_cross_reference: LCH_NW:sh85108335
database_cross_reference: MDR:10003377
database_cross_reference: MDR:10037160
database_cross_reference: MDR:10037162
database_cross_reference: MDR:10037163
database_cross_reference: MEDCIN:31819
database_cross_reference: MEDCIN:319363
database_cross_reference: MEDLINEPLUS:6159
database_cross_reference: MSH:D015535
database_cross_reference: NCI:C61277
database_cross_reference: NCI_NICHD:C61277
database_cross_reference: NDFRT:N0000003287
database_cross_reference: RCD:M160.
database_cross_reference: RCD:M160z
database_cross_reference: SNM:D-3102
database_cross_reference: SNMI:D0-22114
database_cross_reference: SNOMEDCT_US:156370009
database_cross_reference: SNOMEDCT_US:200959009
database_cross_reference: SNOMEDCT_US:33339001

larynx carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the larynx.
PMOID: PMO:00027287
Subclass_of: in situ carcinoma
Synonym: Ca in situ larynx
Synonym: Ca-in-situ larynx NOS
Synonym: Cancer in situ of larynx
Synonym: Carcinoma in situ of Larynx
Synonym: Carcinoma in situ of larynx
Synonym: Carcinoma in situ of larynx (disorder)
Synonym: Carcinoma in situ of larynx NOS
Synonym: Carcinoma in situ of larynx NOS (disorder)
Synonym: Carcinoma in situ of larynx, NOS
Synonym: Carcinoma in situ of the Larynx
Tree Number: T10.2.2.3.6
database_cross_reference: DO:DOID:9011
database_cross_reference: ICD10:D02.0
database_cross_reference: ICD10AM:D02.0
database_cross_reference: ICD10CM:D02.0
database_cross_reference: ICD9CM:231.0
database_cross_reference: MDR:10007370
database_cross_reference: MDR:10023829
database_cross_reference: MDR:10023834
database_cross_reference: MDR:10023835
database_cross_reference: MEDCIN:97313
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C9100
database_cross_reference: NCI_NCI-GLOSS:CDR0000396799
database_cross_reference: PDQ:CDR0000038935
database_cross_reference: RCD:B810.
database_cross_reference: RCD:B810z
database_cross_reference: SNMI:D2-F0502
database_cross_reference: SNOMEDCT_US:189261004
database_cross_reference: SNOMEDCT_US:92634009

esophageal leukoplakia
type: Class
subclass of: esophageal disease
PMOID: PMO:00033450
Subclass_of: esophageal disease
Synonym: Esophageal Epidermoid Metaplasia
Synonym: Esophageal Leukoplakia
Synonym: Esophageal epidermoid metaplasia
Synonym: Esophageal leukoplakia
Synonym: Esophagus Leukoplakia
Synonym: Leucoplakia of esophagus
Synonym: Leucoplakia of oesophagus
Synonym: Leukoplakia esophageal
Synonym: Leukoplakia oesophageal
Synonym: Leukoplakia of Esophagus
Tree Number: T10.8.11.2.8
database_cross_reference: DO:DOID:9021
database_cross_reference: HPO:HP:0012859
database_cross_reference: ICD9CM:530.83
database_cross_reference: MDR:10015385
database_cross_reference: MDR:10024389
database_cross_reference: MDR:10062463
database_cross_reference: MDR:10072766
database_cross_reference: MEDCIN:38251
database_cross_reference: NCI:C3953
database_cross_reference: RCD:J10y1
database_cross_reference: RCDAE:J10y1
database_cross_reference: SNMI:D5-30900
database_cross_reference: SNOMEDCT_US:89057003

intestine carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the intestine.
PMOID: PMO:00027310
Subclass_of: in situ carcinoma
Synonym: Ca in situ bowel NEC/NOS
Synonym: Ca insitu/o+unsp prt/intest
Synonym: Carcinoma in situ of other and unspecified parts of intestine
Synonym: Carcinoma in situ/other+unspecified parts of intestine
Synonym: Other and unspecified parts of intestine
Synonym: [X]Ca insitu/o+unsp prt/intest
Synonym: [X]Carcinoma in situ of other and unspecified parts of intestine
Synonym: [X]Carcinoma in situ of other and unspecified parts of intestine (disorder)
Synonym: [X]Carcinoma in situ/other+unspecified parts of intestine
Tree Number: T10.2.2.3.25
database_cross_reference: DO:DOID:9024
database_cross_reference: ICD10:D01.4
database_cross_reference: ICD10AM:D01.4
database_cross_reference: ICD10CM:D01.4
database_cross_reference: ICD9CM:230.7
database_cross_reference: MDR:10007377
database_cross_reference: RCD:ByuF0
database_cross_reference: RCDSY:ByuF0
database_cross_reference: SNOMEDCT_US:190172008

Zellweger syndrome
type: Class
subclass of: peroxisomal disease
definition: A peroxisomal disease that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes.
PMOID: PMO:00029242
Subclass_of: peroxisomal disease
Synonym: CEREBROHEPATORENAL SYNDROME
Synonym: CHR
Synonym: CHRS
Synonym: Cerebro Hepato Renal Syndrome
Synonym: Cerebro-Hepato-Renal Syndrome
Synonym: Cerebrohepatorenal Syndrome
Synonym: Cerebrohepatorenal syndrome
Synonym: PBD1A
Synonym: PEROXISOME BIOGENESIS DISORDER 1A (ZELLWEGER)
Synonym: ZELLWEGER DIS
Tree Number: T10.6.2.16.5
database_cross_reference: CHV:0000013272
database_cross_reference: CSP:1849-1804
database_cross_reference: DO:DOID:905
database_cross_reference: ICD10CM:E71.510
database_cross_reference: MDR:10053684
database_cross_reference: MDR:10053706
database_cross_reference: MEDCIN:36915
database_cross_reference: MSH:D015211
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.86
database_cross_reference: NCI:C85239
database_cross_reference: NCI_NICHD:C85239
database_cross_reference: NDFRT:N0000003205
database_cross_reference: OMIM:214100
database_cross_reference: OMIM:602136
database_cross_reference: RCD:PKy94
database_cross_reference: SNM:D-5096
database_cross_reference: SNMI:D4-00617
database_cross_reference: SNOMEDCT_US:88469006

bladder carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the bladder.
PMOID: PMO:00027291
Subclass_of: in situ carcinoma
Synonym: Bladder
Synonym: Bladder Ca in situ
Synonym: Bladder Flat CIS
Synonym: Bladder Flat Carcinoma in Situ
Synonym: CIS - Carc in situ of bladder
Synonym: CIS - Carcinoma in situ of bladder
Synonym: Ca in situ bladder
Synonym: Cancer in situ of urinary bladder
Synonym: Carcinoma in situ of Urinary Bladder
Synonym: Carcinoma in situ of bladder
Tree Number: T10.2.2.3.10
database_cross_reference: DO:DOID:9053
database_cross_reference: ICD10:D09.0
database_cross_reference: ICD10AM:D09.0
database_cross_reference: ICD10CM:D09.0
database_cross_reference: ICD9CM:233.7
database_cross_reference: MDR:10007356
database_cross_reference: MDR:10007357
database_cross_reference: MDR:10007400
database_cross_reference: MEDCIN:97980
database_cross_reference: MTH:U000752
database_cross_reference: NCI:C3644
database_cross_reference: RCD:B837.
database_cross_reference: SNMI:D7-F0202
database_cross_reference: SNOMEDCT_US:269650008
database_cross_reference: SNOMEDCT_US:92546004

peroxisomal disease
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that involves peroxisome malfunction.
PMOID: PMO:00029237
Subclass_of: inherited metabolic disorder
Synonym: Disord of peroxisomal function
Synonym: Disorder of Peroxisomal Function
Synonym: Disorder of peroxisomal function
Synonym: Disorder of peroxisomal function (disorder)
Synonym: PEROXISOMAL DIS
Synonym: Peroxisomal Disorder
Synonym: Peroxisomal Disorders
Synonym: Peroxisomal Disorders [Disease/Finding]
Synonym: Peroxisomal Function Disorder
Synonym: Peroxisomal disorder, unspecified
Tree Number: T10.6.2.16
database_cross_reference: CHV:0000027632
database_cross_reference: DO:DOID:906
database_cross_reference: ICD10CM:E71.5
database_cross_reference: ICD10CM:E71.50
database_cross_reference: ICD9CM:277.86
database_cross_reference: LCH_NW:sh90001241
database_cross_reference: MEDCIN:275291
database_cross_reference: MEDCIN:315389
database_cross_reference: MSH:D018901
database_cross_reference: NCI:C85005
database_cross_reference: NCI_NICHD:C85005
database_cross_reference: NDFRT:N0000003876
database_cross_reference: RCD:X40We
database_cross_reference: SNOMEDCT_US:238059005

pityriasis versicolor
type: Class
subclass of: superficial mycosis
definition: A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.
PMOID: PMO:00029287
Subclass_of: superficial mycosis
Synonym: Infection by Malassezia furfur
Synonym: Infection by Pityrosporum furfur
Synonym: Malassezia furfur Infection
Synonym: PV - Pityriasis versicolor
Synonym: Pityriasis Versicolor
Synonym: Pityriasis versicolor
Synonym: Pityriasis versicolor (disorder)
Synonym: Pityriasis versicolour
Synonym: TINEA VERSICOLOR
Synonym: TV - Tinea versicolor
Tree Number: T10.7.1.1.2
database_cross_reference: BI:BI00619
database_cross_reference: CCPSS:1012182
database_cross_reference: CHV:0000012309
database_cross_reference: COSTAR:740
database_cross_reference: DO:DOID:9060
database_cross_reference: ICD10:B36.0
database_cross_reference: ICD10AM:B36.0
database_cross_reference: ICD10CM:B36.0
database_cross_reference: ICD9CM:111.0
database_cross_reference: ICPC2P:S74007
database_cross_reference: ICPC2P:S74010
database_cross_reference: MDR:10035117
database_cross_reference: MDR:10043875
database_cross_reference: MDR:10056131
database_cross_reference: MDR:10056227
database_cross_reference: MEDCIN:33132
database_cross_reference: MSH:D014010
database_cross_reference: MTHICD9:111.0
database_cross_reference: NCI:C112833
database_cross_reference: NCI:C82981
database_cross_reference: NCI_NICHD:C112833
database_cross_reference: NDFRT:N0000002960
database_cross_reference: RCD:AB10.
database_cross_reference: SNM:D-0587
database_cross_reference: SNMI:DE-45800
database_cross_reference: SNOMEDCT_US:154395007
database_cross_reference: SNOMEDCT_US:56454009

Ritter's disease
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.
PMOID: PMO:00029607
Subclass_of: commensal bacterial infectious disease
Synonym: (Staphylococcal) Scalded skin syndrome
Synonym: Dermatitis exfoliativa neonatorum
Synonym: Disease, Ritter
Synonym: Disease, Ritter's
Synonym: Pemphigus neonatorum
Synonym: RITTER DIS
Synonym: RITTERS DIS
Synonym: Ritter Disease
Synonym: Ritter disease
Synonym: Ritter's Disease
Tree Number: T10.7.3.3.8
database_cross_reference: CCPSS:0022519
database_cross_reference: CHV:0000011694
database_cross_reference: DO:DOID:9063
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:L00
database_cross_reference: ICD10AM:L00
database_cross_reference: ICD10CM:L00
database_cross_reference: ICD9CM:695.81
database_cross_reference: MDR:10039199
database_cross_reference: MDR:10039200
database_cross_reference: MDR:10039515
database_cross_reference: MDR:10041929
database_cross_reference: MEDCIN:37029
database_cross_reference: MSH:D013206
database_cross_reference: MTHICD9:695.81
database_cross_reference: NCI:C85077
database_cross_reference: NDFRT:N0000002818
database_cross_reference: RCD:M15y0
database_cross_reference: SNM:M-48260
database_cross_reference: SNMI:DE-14135
database_cross_reference: SNOMEDCT_US:200946001
database_cross_reference: SNOMEDCT_US:367537006
database_cross_reference: SNOMEDCT_US:87758007

leishmaniasis
type: Class
subclass of: parasitic protozoa infectious disease
PMOID: PMO:00029699
Subclass_of: parasitic protozoa infectious disease
Synonym: Leishmaniasis
Synonym: Leishmaniasis Infection Pathway
Tree Number: T10.7.4.2.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91491
database_cross_reference: NCI_KEGG:C91491

systemic lupus erythematosus
type: Class
subclass of: connective tissue disease
definition: A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.
PMOID: PMO:00032029
Subclass_of: connective tissue disease
Synonym: DISSEMINATED LUPUS ERYTHEMATOSUS
Synonym: Disseminated lupus erythematos
Synonym: Disseminated lupus erythematosus
Synonym: LE SYNDROME
Synonym: LE syndrome
Synonym: LE systemic
Synonym: LUPUS
Synonym: LUPUS ERYTHEMATOSIS (NOS)
Synonym: LUPUS ERYTHEMATOSIS DISSEMINATED
Synonym: LUPUS ERYTHEMATOSUS SYSTEMIC
Tree Number: T10.8.4.1.4
database_cross_reference: AOD:0000005185
database_cross_reference: AOD:0000023293
database_cross_reference: BI:BI00326
database_cross_reference: CCPSS:0036348
database_cross_reference: CCPSS:0037396
database_cross_reference: CHV:0000007578
database_cross_reference: COSTAR:718
database_cross_reference: COSTAR:719
database_cross_reference: CSP:0729-7721
database_cross_reference: CST:LE SYND
database_cross_reference: DO:DOID:9074
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001106
database_cross_reference: DXP:U003913
database_cross_reference: HPO:HP:0002725
database_cross_reference: ICD10:M32
database_cross_reference: ICD10:M32.9
database_cross_reference: ICD10AM:M32
database_cross_reference: ICD10AM:M32.9
database_cross_reference: ICD10CM:M32
database_cross_reference: ICD10CM:M32.9
database_cross_reference: ICD9CM:710.0
database_cross_reference: ICPC2P:L99065
database_cross_reference: LCH:U002748
database_cross_reference: LCH_NW:sh85078942
database_cross_reference: LNC:LA15300-9
database_cross_reference: MDR:10013446
database_cross_reference: MDR:10024065
database_cross_reference: MDR:10024067
database_cross_reference: MDR:10025133
database_cross_reference: MDR:10025139
database_cross_reference: MDR:10025142
database_cross_reference: MDR:10040967
database_cross_reference: MDR:10042800
database_cross_reference: MDR:10042820
database_cross_reference: MDR:10042944
database_cross_reference: MDR:10042945
database_cross_reference: MDR:10042947
database_cross_reference: MEDCIN:31847
database_cross_reference: MEDLINEPLUS:82
database_cross_reference: MSH:D008180
database_cross_reference: MTH:719
database_cross_reference: MTH:U002054
database_cross_reference: MTHICD9:710.0
database_cross_reference: NCI:C3201
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000045477
database_cross_reference: NCI_NCI-GLOSS:CDR0000403145
database_cross_reference: NCI_NICHD:C3201
database_cross_reference: NDFRT:N0000001887
database_cross_reference: OMIM:152700
database_cross_reference: OMIM:MTHU016290
database_cross_reference: RCD:N000.
database_cross_reference: RCD:N000z
database_cross_reference: SNM:D-3872
database_cross_reference: SNMI:D1-10100
database_cross_reference: SNOMEDCT_US:156450004
database_cross_reference: SNOMEDCT_US:201435004
database_cross_reference: SNOMEDCT_US:201439005
database_cross_reference: SNOMEDCT_US:55464009

macroglobulinemia
type: Class
subclass of: plasma protein metabolism disease
definition: A B-cell lymphocytic neoplasm characterized by an uncontrolled increase of B-cells.
PMOID: PMO:00029045
Subclass_of: plasma protein metabolism disease
Synonym: Lymphoma, Lymphocytic, Plasmacytoid
Synonym: Lymphoma, Lymphoplasmacytoid
Synonym: Lymphomas, Lymphoplasmacytoid
Synonym: Lymphoplasmacytoid Lymphoma
Synonym: Lymphoplasmacytoid Lymphomas
Synonym: MACROGLOBULINEMIA, WALDENSTROM
Synonym: Macroglobulinaemia
Synonym: Macroglobulinaemia NOS
Synonym: Macroglobulinaemia, Waldenstrom's
Synonym: Macroglobulinemia
Tree Number: T10.6.2.7.3
database_cross_reference: AOD:0000005754
database_cross_reference: CHV:0000007643
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0449-2705
database_cross_reference: CSP:0449-8115
database_cross_reference: DO:DOID:0050747
database_cross_reference: DO:DOID:0060901
database_cross_reference: DO:DOID:9080
database_cross_reference: DXP:U001123
database_cross_reference: HPO:HP:0005508
database_cross_reference: ICD10:C88.0
database_cross_reference: ICD10AM:C88.0
database_cross_reference: ICD10AM:M9761/3
database_cross_reference: ICD10AMAE:C88.0
database_cross_reference: ICD10AMAE:M9761/3
database_cross_reference: ICD10CM:C88.0
database_cross_reference: ICD9CM:273.3
database_cross_reference: MDR:10025389
database_cross_reference: MDR:10025390
database_cross_reference: MDR:10047714
database_cross_reference: MDR:10047801
database_cross_reference: MDR:10047802
database_cross_reference: MDR:10047803
database_cross_reference: MDR:10054693
database_cross_reference: MDR:10054695
database_cross_reference: MDR:10054696
database_cross_reference: MDR:10062831
database_cross_reference: MEDCIN:31733
database_cross_reference: MEDLINEPLUS:117
database_cross_reference: MSH:D008258
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:273.3
database_cross_reference: NCI:C80307
database_cross_reference: NCI_NCI-GLOSS:CDR0000044854
database_cross_reference: NDFRT:N0000001915
database_cross_reference: PDQ:CDR0000037790
database_cross_reference: RCD:C333.
database_cross_reference: RCD:C3330
database_cross_reference: RCD:C333z
database_cross_reference: RCD:XaBLz
database_cross_reference: RCDAE:C333.
database_cross_reference: RCDAE:C3330
database_cross_reference: RCDAE:C333z
database_cross_reference: RCDAE:XaBLz
database_cross_reference: RCDSY:XaBLz
database_cross_reference: SNM:D-4722
database_cross_reference: SNMI:M-97613
database_cross_reference: SNOMEDCT_US:109981009
database_cross_reference: SNOMEDCT_US:154750002
database_cross_reference: SNOMEDCT_US:190014001
database_cross_reference: SNOMEDCT_US:190817009
database_cross_reference: SNOMEDCT_US:190818004
database_cross_reference: SNOMEDCT_US:190821002
database_cross_reference: SNOMEDCT_US:267503004
database_cross_reference: SNOMEDCT_US:35562000

anal carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the anus.
PMOID: PMO:00027307
Subclass_of: in situ carcinoma
Synonym: AIN III
Synonym: Anal cancer stage 0
Synonym: Anal carcinoma in situ
Synonym: Anal intraepithelial neoplasia grade III
Synonym: Anal intraepithelial neoplasia grade III (disorder)
Synonym: Anal intraepithelial neoplasia, grade III
Synonym: Ca in situ anus NOS
Synonym: Carcinoma in situ of anus
Synonym: Carcinoma in situ of anus (disorder)
Synonym: Carcinoma in situ of anus NOS
Tree Number: T10.2.2.3.22
database_cross_reference: DO:DOID:9087
database_cross_reference: ICD9CM:230.6
database_cross_reference: MDR:10002134
database_cross_reference: MDR:10002142
database_cross_reference: MDR:10007355
database_cross_reference: MEDCIN:97948
database_cross_reference: MEDCIN:99793
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:232.5
database_cross_reference: RCD:B806.
database_cross_reference: RCD:X78OQ
database_cross_reference: SNMI:D5-F1422
database_cross_reference: SNOMEDCT_US:189233005
database_cross_reference: SNOMEDCT_US:20365006
database_cross_reference: SNOMEDCT_US:401311008
database_cross_reference: SNOMEDCT_US:92537005

REM sleep behavior disorder
type: Class
subclass of: sleep disorder
definition: A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.
PMOID: PMO:00027894
Subclass_of: sleep disorder
Synonym: BEHAVIOR DIS RAPID EYE MOVEMENT SLEEP
Synonym: BEHAVIOR DIS REM
Synonym: Behavior Disorder, REM
Synonym: Behavior Disorder, Rapid Eye Movement Sleep
Synonym: Behavior Disorders, REM
Synonym: RAPID EYE MOVEMENT SLEEP BEHAVIOR DIS
Synonym: REM BEHAVIOR DIS
Synonym: REM Behavior Disorder
Synonym: REM Behavior Disorders
Synonym: REM SLEEP BEHAVIOR DIS
Tree Number: T10.3.1.6
database_cross_reference: CHV:0000048489
database_cross_reference: DO:DOID:9091
database_cross_reference: DSM-5:327.42
database_cross_reference: DSM-5:G47.52
database_cross_reference: ICD10CM:G47.52
database_cross_reference: ICD9CM:327.42
database_cross_reference: MDR:10077299
database_cross_reference: MDR:10077300
database_cross_reference: MDR:10078722
database_cross_reference: MDR:10078725
database_cross_reference: MEDCIN:279066
database_cross_reference: MEDCIN:358354
database_cross_reference: MSH:D020187
database_cross_reference: NDFRT:N0000004026
database_cross_reference: OMIM:MTHU042628
database_cross_reference: SNOMEDCT_US:415238003

esophagus carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the esophagus.
PMOID: PMO:00027304
Subclass_of: in situ carcinoma
Synonym: Ca in situ esophagus
Synonym: Ca-in-situ esophagus NOS
Synonym: Ca-in-situ oesophagus NOS
Synonym: Cancer in situ of esophagus
Synonym: Cancer in situ of oesophagus
Synonym: Carcinoma in situ esophagus
Synonym: Carcinoma in situ oesophagus
Synonym: Carcinoma in situ of esophagus
Synonym: Carcinoma in situ of esophagus (disorder)
Synonym: Carcinoma in situ of esophagus NOS
Tree Number: T10.2.2.3.19
database_cross_reference: DO:DOID:9095
database_cross_reference: ICD10:D00.1
database_cross_reference: ICD10AM:D00.1
database_cross_reference: ICD10AMAE:D00.1
database_cross_reference: ICD10CM:D00.1
database_cross_reference: ICD9CM:230.1
database_cross_reference: MDR:10007367
database_cross_reference: MDR:10007373
database_cross_reference: MDR:10015369
database_cross_reference: MDR:10015374
database_cross_reference: MDR:10015375
database_cross_reference: MDR:10030156
database_cross_reference: MDR:10030158
database_cross_reference: MDR:10030161
database_cross_reference: MDR:10030162
database_cross_reference: MEDCIN:97305
database_cross_reference: MTH:U001032
database_cross_reference: NCI:C89771
database_cross_reference: NCI_NCI-GLOSS:CDR0000352152
database_cross_reference: PDQ:CDR0000043665
database_cross_reference: RCD:B801.
database_cross_reference: RCD:B801z
database_cross_reference: RCD:XaBeD
database_cross_reference: RCDAE:B801.
database_cross_reference: RCDAE:B801z
database_cross_reference: RCDAE:XaBeD
database_cross_reference: SNMI:D5-F1002
database_cross_reference: SNOMEDCT_US:189217007
database_cross_reference: SNOMEDCT_US:308860001
database_cross_reference: SNOMEDCT_US:92585006

erythematosquamous dermatosis
type: Class
subclass of: skin disease
PMOID: PMO:00033886
Subclass_of: skin disease
Synonym: Erythematosqamous dermatos NOS
Synonym: Erythematosquamous Dermatosis
Synonym: Erythematosquamous dermatosis
Synonym: Erythematosquamous dermatosis (disorder)
Synonym: Erythematosquamous dermatosis NOS
Synonym: Erythematosquamous dermatosis NOS (disorder)
Synonym: Erythematosquamous dermatosis, NOS
Synonym: Other erythematosquamous dermatosis
Synonym: erythematosquamous dermatosis (diagnosis)
Tree Number: T10.8.12.2.19
database_cross_reference: DO:DOID:9097
database_cross_reference: ICD9CM:690
database_cross_reference: ICPC2P:S86005
database_cross_reference: MDR:10015239
database_cross_reference: MEDCIN:98700
database_cross_reference: NCI:C34591
database_cross_reference: RCD:M10..
database_cross_reference: RCD:M10z.
database_cross_reference: SNMI:D0-20050
database_cross_reference: SNOMEDCT_US:200762004
database_cross_reference: SNOMEDCT_US:200768000
database_cross_reference: SNOMEDCT_US:54792008

sebaceous gland disease
type: Class
subclass of: skin disease
PMOID: PMO:00033864
Subclass_of: skin disease
Synonym: 0-51 DISEASES OF THE SEBACEOUS GLANDS
Synonym: DISEASES OF THE SEBACEOUS GLANDS
Synonym: Disease of sebaceous gland
Synonym: Disease of sebaceous gland (disorder)
Synonym: Disease of sebaceous glands
Synonym: Disease of sebaceous glands (disorder)
Synonym: Disease of sebaceous glands, NOS
Synonym: Disease, Sebaceous Gland
Synonym: Diseases of sebaceous glands
Synonym: Diseases, Sebaceous Gland
Tree Number: T10.8.12.2.12
database_cross_reference: CCPSS:0037646
database_cross_reference: CHV:0000011146
database_cross_reference: CST:SKIN/SBGL
database_cross_reference: ICD9CM:706
database_cross_reference: ICD9CM:706.9
database_cross_reference: LCH_NW:sh85119390
database_cross_reference: MDR:10013133
database_cross_reference: MDR:10039781
database_cross_reference: MDR:10039782
database_cross_reference: MDR:10045756
database_cross_reference: MDR:10061511
database_cross_reference: MEDCIN:210877
database_cross_reference: MSH:D012625
database_cross_reference: NDFRT:N0000002710
database_cross_reference: RCD:M26..
database_cross_reference: RCD:M26z.
database_cross_reference: SNMI:D0-51000
database_cross_reference: SNOMEDCT_US:156418009
database_cross_reference: SNOMEDCT_US:156422004
database_cross_reference: SNOMEDCT_US:201247008
database_cross_reference: SNOMEDCT_US:3441005

uterus carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the uterus.
PMOID: PMO:00027306
Subclass_of: in situ carcinoma
Synonym: Ca in situ uterus NEC
Synonym: Ca-in-situ other part uterus
Synonym: Carcinoma in situ of other and unspecified parts of uterus
Synonym: Carcinoma in situ of other and unspecified parts of uterus (disorder)
Tree Number: T10.2.2.3.21
database_cross_reference: DO:DOID:9108
database_cross_reference: ICD9CM:233.2
database_cross_reference: MDR:10007378
database_cross_reference: RCD:XE1wI
database_cross_reference: SNOMEDCT_US:189342001
database_cross_reference: SNOMEDCT_US:269492005

granuloma inguinale
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in skin or located_in mucosa of genital tract, has_material_basis_in Klebsiella granulomatis, transmitted by sexual contact or transmitted_by contact with the open sores. The infection has_symptom painless genital ulcers.
PMOID: PMO:00029586
Subclass_of: primary bacterial infectious disease
Synonym: (Granuloma inguinale) or (donovanosis) or (pudendal ulcer)
Synonym: (Granuloma inguinale) or (donovanosis) or (pudendal ulcer) (disorder)
Synonym: Calymmatobacterium granulomatis infection
Synonym: DONOVANOSIS
Synonym: Donovanosis
Synonym: Donovanosis;F
Synonym: Donovanosis;M
Synonym: E-121 GRANULOMA INGUINALE
Synonym: GI - Granuloma inguinale
Synonym: GRANULOMA INGUINALE
Tree Number: T10.7.3.1.38
database_cross_reference: CHV:0000005685
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0368-2705
database_cross_reference: DO:DOID:9113
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000751
database_cross_reference: ICD10:A58
database_cross_reference: ICD10AM:A58
database_cross_reference: ICD10CM:A58
database_cross_reference: ICD9CM:099.2
database_cross_reference: ICPC2P:X92003
database_cross_reference: ICPC2P:Y99020
database_cross_reference: LCH_NW:sh85056445
database_cross_reference: MDR:10007043
database_cross_reference: MDR:10018693
database_cross_reference: MEDCIN:30965
database_cross_reference: MSH:D006100
database_cross_reference: MTHICD9:099.2
database_cross_reference: NCI:C3065
database_cross_reference: NDFRT:N0000001386
database_cross_reference: RCD:XE0S2
database_cross_reference: SNM:D-0132
database_cross_reference: SNMI:DE-12100
database_cross_reference: SNOMEDCT_US:186947000
database_cross_reference: SNOMEDCT_US:28867007

amyloidosis
type: Class
subclass of: acquired metabolic disease
definition: An acquired metabolic disease that involves abnormal deposited of amyloid proteins in organs and/or tissues.
PMOID: PMO:00028842
Subclass_of: acquired metabolic disease
Synonym: AMYLOID
Synonym: AMYLOIDOSIS
Synonym: Amyloid disease
Synonym: Amyloidoses
Synonym: Amyloidosis
Synonym: Amyloidosis (disorder)
Synonym: Amyloidosis NOS
Synonym: Amyloidosis NOS (disorder)
Synonym: Amyloidosis [Disease/Finding]
Synonym: Amyloidosis, NOS
Tree Number: T10.6.1.2
database_cross_reference: AOD:0000005846
database_cross_reference: CCPSS:0052113
database_cross_reference: CHV:0000001070
database_cross_reference: COSTAR:U000030
database_cross_reference: CSP:1849-1519
database_cross_reference: CST:AMYLOIDOSIS
database_cross_reference: CST:PATHAMYLOID
database_cross_reference: DO:DOID:9120
database_cross_reference: HPO:HP:0011034
database_cross_reference: ICD10:E85
database_cross_reference: ICD10:E85.9
database_cross_reference: ICD10AM:E85
database_cross_reference: ICD10AM:E85.9
database_cross_reference: ICD10CM:E85
database_cross_reference: ICD10CM:E85.9
database_cross_reference: ICD9CM:277.3
database_cross_reference: ICD9CM:277.30
database_cross_reference: ICPC2P:T99006
database_cross_reference: LCH:U000219
database_cross_reference: LCH_NW:sh85004724
database_cross_reference: MDR:10002021
database_cross_reference: MDR:10002022
database_cross_reference: MDR:10002023
database_cross_reference: MDR:10002024
database_cross_reference: MEDCIN:31790
database_cross_reference: MEDLINEPLUS:5273
database_cross_reference: MSH:D000686
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.30
database_cross_reference: NCI:C2868
database_cross_reference: NCI_CDISC:C2868
database_cross_reference: NCI_CDISC:SEND-NONNEO
database_cross_reference: NCI_CTEP-SDC:10002024
database_cross_reference: NCI_NCI-GLOSS:CDR0000045507
database_cross_reference: NDFRT:N0000000375
database_cross_reference: PDQ:CDR0000041926
database_cross_reference: RCD:C373.
database_cross_reference: RCD:C373z
database_cross_reference: SNM:D-3890
database_cross_reference: SNMI:D6-94500
database_cross_reference: SNOMEDCT_US:154769007
database_cross_reference: SNOMEDCT_US:17602002
database_cross_reference: SNOMEDCT_US:190931005

eczema herpeticum
type: Class
subclass of: herpes simplex
PMOID: PMO:00029369
Subclass_of: herpes simplex
Synonym: Eczema Herpeticum
Synonym: Eczema herpeticum
Synonym: Eczema herpeticum (disorder)
Synonym: Eczema herpeticum (disorder) [Ambiguous]
Synonym: eczema herpeticum (diagnosis)
Synonym: herpeticum eczema
Tree Number: T10.7.2.20.2
database_cross_reference: CHV:0000052864
database_cross_reference: ICD10:B00.0
database_cross_reference: ICD10AM:B00.0
database_cross_reference: ICD10CM:B00.0
database_cross_reference: ICD9CM:054.0
database_cross_reference: MDR:10014197
database_cross_reference: MEDCIN:30975
database_cross_reference: MSH:D007617
database_cross_reference: RCD:A540.
database_cross_reference: SNM:D-0405
database_cross_reference: SNMI:DE-32181
database_cross_reference: SNOMEDCT_US:186535001
database_cross_reference: SNOMEDCT_US:52464003

liver carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the liver.
PMOID: PMO:00027293
Subclass_of: in situ carcinoma
Synonym: Ca in situ liver/biliary
Synonym: Ca-in-situ liver/biliary NOS
Synonym: Ca-in-situ liver/biliary syst.
Synonym: Carcinoma in situ of liver and biliary system
Synonym: Carcinoma in situ of liver and biliary system (disorder)
Synonym: Carcinoma in situ of liver and/or biliary system
Synonym: Carcinoma in situ of liver and/or biliary system (disorder)
Synonym: Carcinoma in situ of liver or biliary system NOS
Synonym: Carcinoma in situ of liver or biliary system NOS (disorder)
Synonym: Carcinoma in situ of liver, gallbladder and bile ducts
Tree Number: T10.2.2.3.12
database_cross_reference: DO:DOID:9132
database_cross_reference: ICD10:D01.5
database_cross_reference: ICD10AM:D01.5
database_cross_reference: ICD10CM:D01.5
database_cross_reference: ICD9CM:230.8
database_cross_reference: MDR:10007372
database_cross_reference: MDR:10019804
database_cross_reference: MDR:10019820
database_cross_reference: MDR:10061202
database_cross_reference: MDR:10073074
database_cross_reference: MTH:U001402
database_cross_reference: RCD:B808z
database_cross_reference: RCD:XE2xA
database_cross_reference: SNOMEDCT_US:189241005
database_cross_reference: SNOMEDCT_US:189247009
database_cross_reference: SNOMEDCT_US:271525004

stomach carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the stomach.
PMOID: PMO:00027288
Subclass_of: in situ carcinoma
Synonym: Ca in situ stomach
Synonym: Ca-in-situ stomach NOS
Synonym: Carcinoma in situ of Stomach
Synonym: Carcinoma in situ of stomach
Synonym: Carcinoma in situ of stomach (disorder)
Synonym: Carcinoma in situ of stomach NOS
Synonym: Carcinoma in situ of stomach NOS (disorder)
Synonym: Carcinoma in situ of stomach, NOS
Synonym: Carcinoma in situ of the Stomach
Synonym: Carcinoma of Stomach Stage 0
Tree Number: T10.2.2.3.7
database_cross_reference: DO:DOID:9138
database_cross_reference: ICD10:D00.2
database_cross_reference: ICD10AM:D00.2
database_cross_reference: ICD10CM:D00.2
database_cross_reference: ICD9CM:230.2
database_cross_reference: MDR:10007399
database_cross_reference: MDR:10017759
database_cross_reference: MDR:10017762
database_cross_reference: MDR:10017771
database_cross_reference: MDR:10017773
database_cross_reference: MDR:10017797
database_cross_reference: MDR:10017799
database_cross_reference: MDR:10042081
database_cross_reference: MDR:10042083
database_cross_reference: MDR:10042091
database_cross_reference: MDR:10042093
database_cross_reference: MEDCIN:97306
database_cross_reference: MTH:U000744
database_cross_reference: NCI:C7788
database_cross_reference: NCI_NCI-GLOSS:CDR0000352154
database_cross_reference: PDQ:CDR0000042595
database_cross_reference: RCD:B802.
database_cross_reference: RCD:B802z
database_cross_reference: SNMI:D5-F1102
database_cross_reference: SNOMEDCT_US:189223002
database_cross_reference: SNOMEDCT_US:92756002

variola minor
type: Class
subclass of: smallpox
definition: A smallpox that results_in milder infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions.
PMOID: PMO:00029434
Subclass_of: smallpox
Synonym: Alastrim
Synonym: Alastrim (disorder)
Synonym: Amaas
Synonym: Kaffir pox
Synonym: Minor, Variola
Synonym: Minors, Variola
Synonym: Variola Minor
Synonym: Variola Minors
Synonym: Variola minor
Synonym: alastrim
Tree Number: T10.7.2.66.2
database_cross_reference: CHV:0000000854
database_cross_reference: DO:DOID:9153
database_cross_reference: ICD9CM:050.1
database_cross_reference: LCH:U000123
database_cross_reference: MDR:10001555
database_cross_reference: MEDCIN:97411
database_cross_reference: MSH:D012899
database_cross_reference: MTHICD9:050.1
database_cross_reference: NCI:C34365
database_cross_reference: RCD:A501.
database_cross_reference: SNM:D-0354
database_cross_reference: SNMI:DE-31450
database_cross_reference: SNOMEDCT_US:72294005

gas gangrene
type: Class
subclass of: commensal bacterial infectious disease
definition: A commensal bacterial infectious disease that results in infection, located in muscle tissue, has material basis in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis.
PMOID: PMO:00029611
Subclass_of: commensal bacterial infectious disease
Synonym: Clostridial myonecrosis
Synonym: Clostridial myositis
Synonym: Clostridial myositis as a result of gas gangrene
Synonym: GANGRENE GAS
Synonym: GANGRENE, GAS
Synonym: Gangrene, Gas
Synonym: Gangrene, gas
Synonym: Gangrenes, Gas
Synonym: Gas Gangrene
Synonym: Gas Gangrene [Disease/Finding]
Tree Number: T10.7.3.3.11
database_cross_reference: CCPSS:1000543
database_cross_reference: CHV:0000005353
database_cross_reference: DO:DOID:9159
database_cross_reference: DXP:U000695
database_cross_reference: ICD10:A48.0
database_cross_reference: ICD10AM:A48.0
database_cross_reference: ICD10CM:A48.0
database_cross_reference: ICD9CM:040.0
database_cross_reference: LCH:U001917
database_cross_reference: LCH_NW:sh85053301
database_cross_reference: MDR:10017737
database_cross_reference: MEDCIN:273132
database_cross_reference: MEDCIN:273197
database_cross_reference: MEDCIN:31222
database_cross_reference: MEDCIN:33809
database_cross_reference: MEDLINEPLUS:5580
database_cross_reference: MSH:D005738
database_cross_reference: MTHICD9:040.0
database_cross_reference: NDFRT:N0000001311
database_cross_reference: RCD:XE0R0
database_cross_reference: SNM:D-0129
database_cross_reference: SNM:M-54640
database_cross_reference: SNMI:DE-11A10
database_cross_reference: SNOMEDCT_US:186407003
database_cross_reference: SNOMEDCT_US:186413007
database_cross_reference: SNOMEDCT_US:276198000
database_cross_reference: SNOMEDCT_US:80466000

achalasia
type: Class
subclass of: esophageal disease
definition: An esophageal disease that is characterized by an inability of the esophagus to move food toward the stomach resulting from the lower esophogeal sphincter not fully relaxing during swallowing.
PMOID: PMO:00033442
Subclass_of: esophageal disease
Synonym: ACHALASIA
Synonym: ACHALASIA CARDIAE
Synonym: ACHALASIA ESOPHAGEAL
Synonym: Achalasia
Synonym: Achalasia & cardiospasm
Synonym: Achalasia and cardiospasm
Synonym: Achalasia cardiae
Synonym: Achalasia esophageal
Synonym: Achalasia oesophageal
Synonym: Achalasia of cardia
Tree Number: T10.8.11.2.4
database_cross_reference: AOD:0000005539
database_cross_reference: AOD:0000005540
database_cross_reference: CHV:0000004646
database_cross_reference: CSP:1248-5473
database_cross_reference: CST:CARDIOSPASM
database_cross_reference: DO:DOID:9164
database_cross_reference: DXP:U000295
database_cross_reference: HPO:HP:0002571
database_cross_reference: ICD10:K22.0
database_cross_reference: ICD10AM:K22.0
database_cross_reference: ICD10CM:K22.0
database_cross_reference: ICD9CM:530.0
database_cross_reference: ICPC2P:D84001
database_cross_reference: LCH:U005525
database_cross_reference: LCH_NW:sh85020220
database_cross_reference: MDR:10000421
database_cross_reference: MDR:10000422
database_cross_reference: MDR:10000423
database_cross_reference: MDR:10007645
database_cross_reference: MDR:10030136
database_cross_reference: MDR:10030226
database_cross_reference: MDR:10055457
database_cross_reference: MDR:10055497
database_cross_reference: MDR:10055966
database_cross_reference: MEDCIN:30002
database_cross_reference: MEDLINEPLUS:246
database_cross_reference: MSH:D004931
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:530.0
database_cross_reference: NCI:C84699
database_cross_reference: NDFRT:N0000001155
database_cross_reference: OMIM:MTHU042069
database_cross_reference: RCD:J100.
database_cross_reference: SNM:F-60990
database_cross_reference: SNM:F-61030
database_cross_reference: SNMI:D5-30202
database_cross_reference: SNMI:D5-30220
database_cross_reference: SNOMEDCT_US:155672003
database_cross_reference: SNOMEDCT_US:17460002
database_cross_reference: SNOMEDCT_US:45564002
database_cross_reference: SNOMEDCT_VET:45564002

Wiskott-Aldrich syndrome
type: Class
subclass of: X-linked disease
PMOID: PMO:00028732
Subclass_of: X-linked disease
Synonym: ALDRICH SYNDROME
Synonym: Aldrich Syndrome
Synonym: Aldrich syndrome
Synonym: ECZEMA-THROMBOCYTOPENIA-IMMUNODEFICIENCY SYNDROME
Synonym: Eczema Thrombocytopenia Immunodeficiency Syndrome
Synonym: Eczema+thromb'paenia+imundefic
Synonym: Eczema, thrombocytopenia, immunodeficiency syndrome
Synonym: Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Synonym: Eczema-Thrombocytopenia-Immunodeficiency Syndromes
Synonym: IMD2
Tree Number: T10.5.3.4.12
database_cross_reference: CHV:0000013173
database_cross_reference: CSP:1849-0285
database_cross_reference: DO:DOID:9169
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002027
database_cross_reference: ICD10:D82.0
database_cross_reference: ICD10AM:D82.0
database_cross_reference: ICD10CM:D82.0
database_cross_reference: ICD9CM:279.12
database_cross_reference: MDR:10001659
database_cross_reference: MDR:10047992
database_cross_reference: MEDCIN:31865
database_cross_reference: MSH:D014923
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3448
database_cross_reference: NCI_NCI-GLOSS:CDR0000539110
database_cross_reference: NCI_NCI-GLOSS:CDR0000562657
database_cross_reference: NDFRT:N0000003164
database_cross_reference: OMIM:277970
database_cross_reference: OMIM:300392
database_cross_reference: OMIM:301000
database_cross_reference: RCD:C3912
database_cross_reference: SNM:D-4612
database_cross_reference: SNMI:DC-51210
database_cross_reference: SNOMEDCT_US:36070007

rectum carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the rectum.
PMOID: PMO:00027294
Subclass_of: in situ carcinoma
Synonym: Ca in situ rectum
Synonym: Cancer in situ of rectum
Synonym: Carcinoma in situ of Rectum
Synonym: Carcinoma in situ of rectum
Synonym: Carcinoma in situ of rectum (disorder)
Synonym: Carcinoma in situ of the Rectum
Synonym: Marked Dysplasia of Rectum
Synonym: Marked Dysplasia of the Rectum
Synonym: Marked Rectal Dysplasia
Synonym: Rectal Carcinoma in situ
Tree Number: T10.2.2.3.13
database_cross_reference: DO:DOID:9174
database_cross_reference: ICD10:D01.2
database_cross_reference: ICD10AM:D01.2
database_cross_reference: ICD10CM:D01.2
database_cross_reference: ICD9CM:230.4
database_cross_reference: MDR:10007386
database_cross_reference: MDR:10038047
database_cross_reference: MDR:10038053
database_cross_reference: MDR:10038055
database_cross_reference: MEDCIN:97308
database_cross_reference: MTH:U000696
database_cross_reference: NCI:C4853
database_cross_reference: PDQ:CDR0000043235
database_cross_reference: RCD:B8041
database_cross_reference: RCD:XaBeh
database_cross_reference: SNMI:D5-F1402
database_cross_reference: SNOMEDCT_US:308879003
database_cross_reference: SNOMEDCT_US:92696009

amebiasis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.
PMOID: PMO:00029680
Subclass_of: parasitic protozoa infectious disease
Synonym: AMEBIC DYSENTERY
Synonym: Amebiases, Intestinal
Synonym: Amebiasis
Synonym: Amebiasis, Intestinal
Synonym: Amebic Colitides
Synonym: Amebic Colitis
Synonym: Amebic Dysenteries
Synonym: Amebic Dysentery
Synonym: Amebic colitis
Synonym: Amebic colitis (diagnosis)
Tree Number: T10.7.4.2.2
database_cross_reference: AOD:0000005635
database_cross_reference: CCPSS:0015909
database_cross_reference: CCPSS:0052767
database_cross_reference: CHV:0000004204
database_cross_reference: DO:DOID:0050228
database_cross_reference: DO:DOID:9180
database_cross_reference: DO:DOID:9181
database_cross_reference: DXP:NOCODE
database_cross_reference: ICPC2P:D70009
database_cross_reference: ICPC2P:D70024
database_cross_reference: LNC:LA10431-7
database_cross_reference: MDR:10001920
database_cross_reference: MDR:10001985
database_cross_reference: MDR:10001986
database_cross_reference: MDR:10022639
database_cross_reference: MDR:10062809
database_cross_reference: MDR:10062811
database_cross_reference: MEDCIN:351269
database_cross_reference: MEDCIN:354684
database_cross_reference: MSH:D004404
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34558
database_cross_reference: NDFRT:N0000001017
database_cross_reference: RCD:X303l
database_cross_reference: RCDAE:X303l
database_cross_reference: SNM:D-0651
database_cross_reference: SNMI:DE-50200
database_cross_reference: SNOMEDCT_US:111909004
database_cross_reference: SNOMEDCT_US:235747003
database_cross_reference: SNOMEDCT_US:387754006

dyskinesia of esophagus
type: Class
subclass of: esophageal disease
PMOID: PMO:00033448
Subclass_of: esophageal disease
Synonym: Disorder, Esophageal Motility
Synonym: Disorders, Esophageal Motility
Synonym: Dyskinesia esophageal
Synonym: Dyskinesia oesophageal
Synonym: Dyskinesia of esophagus
Synonym: Dyskinesia of esophagus (disorder)
Synonym: Dyskinesia of oesophagus
Synonym: Dysmotilities, Esophageal
Synonym: Dysmotility, Esophageal
Synonym: Dysmotility;esophageal
Tree Number: T10.8.11.2.6
database_cross_reference: CCPSS:1017494
database_cross_reference: CHV:0000004653
database_cross_reference: COSTAR:U000251
database_cross_reference: DO:DOID:9192
database_cross_reference: ICD10:K22.4
database_cross_reference: ICD10AM:K22.4
database_cross_reference: ICD10AMAE:K22.4
database_cross_reference: ICD10CM:K22.4
database_cross_reference: ICD9CM:530.5
database_cross_reference: ICPC2P:D84019
database_cross_reference: MDR:10013924
database_cross_reference: MDR:10013925
database_cross_reference: MDR:10013926
database_cross_reference: MDR:10055456
database_cross_reference: MDR:10072419
database_cross_reference: MDR:10072420
database_cross_reference: MEDCIN:276043
database_cross_reference: MSH:D015154
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003189
database_cross_reference: OMIM:MTHU030304
database_cross_reference: OMIM:MTHU030314
database_cross_reference: RCD:XE0aN
database_cross_reference: RCDAE:XE0aN
database_cross_reference: SNMI:D5-30200
database_cross_reference: SNMI:D5-30600
database_cross_reference: SNOMEDCT_US:196614005
database_cross_reference: SNOMEDCT_US:266434009
database_cross_reference: SNOMEDCT_US:40846004
database_cross_reference: SNOMEDCT_US:61100004
database_cross_reference: SNOMEDCT_US:79962008

Barrett's esophagus
type: Class
subclass of: esophageal disease
PMOID: PMO:00033449
Subclass_of: esophageal disease
Synonym: BARRETT ESOPHAGUS
Synonym: BARRETT METAPLASIA
Synonym: BARRETT'S ESOPHAGUS
Synonym: BE
Synonym: BO - Barrett's esophagus
Synonym: BO - Barrett's oesophagus
Synonym: Barret syndrome
Synonym: Barrett Esophagus
Synonym: Barrett Esophagus [Disease/Finding]
Synonym: Barrett Metaplasia
Tree Number: T10.8.11.2.7
database_cross_reference: BI:BI00211
database_cross_reference: CCPSS:0051188
database_cross_reference: CHV:0000001706
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:5000-0039
database_cross_reference: DO:DOID:9206
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000191
database_cross_reference: HPO:HP:0100580
database_cross_reference: ICD10CM:K22.7
database_cross_reference: ICD10CM:K22.70
database_cross_reference: ICD9CM:530.85
database_cross_reference: ICPC2P:D84018
database_cross_reference: ICPC2P:D86009
database_cross_reference: LCH_NW:sh2006020260
database_cross_reference: LNC:LA14288-7
database_cross_reference: MDR:10004134
database_cross_reference: MDR:10004135
database_cross_reference: MDR:10004137
database_cross_reference: MDR:10053999
database_cross_reference: MDR:10056095
database_cross_reference: MDR:10072776
database_cross_reference: MEDCIN:30103
database_cross_reference: MEDLINEPLUS:246
database_cross_reference: MSH:D001471
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2891
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046013
database_cross_reference: NDFRT:N0000000531
database_cross_reference: OMIM:614266
database_cross_reference: PDQ:CDR0000496926
database_cross_reference: RCD:Xa9Bz
database_cross_reference: RCDAE:Xa9Bz
database_cross_reference: SNM:M-73330
database_cross_reference: SNMI:D5-30910
database_cross_reference: SNOMEDCT_US:155679007
database_cross_reference: SNOMEDCT_US:196603007
database_cross_reference: SNOMEDCT_US:196609006
database_cross_reference: SNOMEDCT_US:235597001
database_cross_reference: SNOMEDCT_US:302914006
database_cross_reference: SNOMEDCT_US:76355008

periodic limb movement disorder
type: Class
subclass of: sleep disorder
definition: A sleep disorder that involves involuntary limb movement during sleep.
PMOID: PMO:00027893
Subclass_of: sleep disorder
Synonym: EXCESSIVE PERIODIC SLEEP RELAT LEG MOVEMENTS
Synonym: Excessive Periodic Sleep Related Leg Movements
Synonym: Excessive Periodic Sleep-Related Leg Movements
Synonym: Myoclonus Syndrome, Nocturnal
Synonym: Myoclonus Syndrome, Sleep
Synonym: Myoclonus Syndromes, Sleep
Synonym: Nocturnal Myoclonus Syndrome
Synonym: Nocturnal Myoclonus Syndrome [Disease/Finding]
Synonym: Nocturnal Myoclonus Syndromes
Synonym: PERIODIC LEG MOVEMENTS EXCESSIVE SLEEP RELAT
Tree Number: T10.3.1.5
database_cross_reference: CHV:0000048490
database_cross_reference: DO:DOID:9207
database_cross_reference: ICD10CM:G47.61
database_cross_reference: ICD9CM:327.51
database_cross_reference: MDR:10064500
database_cross_reference: MDR:10064600
database_cross_reference: MSH:D020189
database_cross_reference: NDFRT:N0000004028
database_cross_reference: SNOMEDCT_US:418763003

geniculate herpes zoster
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.
PMOID: PMO:00029366
Subclass_of: viral infectious disease
Synonym: (Geniculate herpes zoster) or (Ramsey Hunt syndrome)
Synonym: (Geniculate herpes zoster) or (Ramsey Hunt syndrome) (disorder)
Synonym: Auricular Syndrome of Ramsay Hunt
Synonym: Ganglionitis, Herpetic Geniculate
Synonym: Geniculate Ganglionitides, Herpetic
Synonym: Geniculate Ganglionitis, Herpetic
Synonym: Geniculate Herpes Zoster
Synonym: Geniculate Neuralgia
Synonym: Geniculate Neuralgias
Synonym: Geniculate herpes zoster
Tree Number: T10.7.2.19
database_cross_reference: CCPSS:0022472
database_cross_reference: CHV:0000005442
database_cross_reference: DO:DOID:9210
database_cross_reference: ICD10CM:B02.21
database_cross_reference: ICD9CM:053.11
database_cross_reference: MDR:10018141
database_cross_reference: MDR:10037834
database_cross_reference: MDR:10063491
database_cross_reference: MEDCIN:318351
database_cross_reference: MEDCIN:32385
database_cross_reference: MSH:D016697
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:053.11
database_cross_reference: NCI:C84763
database_cross_reference: NDFRT:N0000003456
database_cross_reference: RCD:F5016
database_cross_reference: SNM:D-0406
database_cross_reference: SNM:D-8365
database_cross_reference: SNM:F-82800
database_cross_reference: SNMI:DE-32430
database_cross_reference: SNOMEDCT_US:154330004
database_cross_reference: SNOMEDCT_US:186518000
database_cross_reference: SNOMEDCT_US:186529001
database_cross_reference: SNOMEDCT_US:21954000

central sleep apnea
type: Class
subclass of: sleep apnea
definition: A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.
PMOID: PMO:00027890
Subclass_of: sleep apnea
Synonym: APNEA, CENTRAL SLEEP
Synonym: Alveolar Hypoventilation, Central
Synonym: Alveolar Hypoventilations, Central
Synonym: Apnea, Central
Synonym: Apnea, Central Sleep
Synonym: Apnea, Sleep, Central
Synonym: Apneas, Central
Synonym: Apneas, Central Sleep
Synonym: Breathing, Central Sleep-Disordered
Synonym: Breathings, Central Sleep-Disordered
Tree Number: T10.3.1.3.2
database_cross_reference: CHV:0000037772
database_cross_reference: DO:DOID:9220
database_cross_reference: HPO:HP:0002871
database_cross_reference: HPO:HP:0010536
database_cross_reference: MEDCIN:270274
database_cross_reference: MSH:D020182
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C116046
database_cross_reference: NCI_NICHD:C116046
database_cross_reference: NDFRT:N0000004022
database_cross_reference: OMIM:107640
database_cross_reference: OMIM:207720
database_cross_reference: RCD:X0085
database_cross_reference: RCDAE:X0085

kidney carcinoma in situ
type: Class
subclass of: in situ carcinoma
definition: An in situ carcinoma that is located_in the kidney.
PMOID: PMO:00027282
Subclass_of: in situ carcinoma
Synonym: Ca in situ urinary NEC
Synonym: Ca insitu/o+unsp urinry org
Synonym: Carcinoma in situ of other and unspecified urinary organs
Synonym: Other and unspecified urinary organs
Synonym: [X]Ca insitu/o+unsp urinry org
Synonym: [X]Carcinoma in situ of other and unspecified urinary organs
Synonym: [X]Carcinoma in situ of other and unspecified urinary organs (disorder)
Tree Number: T10.2.2.3.1
database_cross_reference: DO:DOID:9234
database_cross_reference: ICD10:D09.1
database_cross_reference: ICD10AM:D09.1
database_cross_reference: ICD10CM:D09.1
database_cross_reference: ICD9CM:233.9
database_cross_reference: MDR:10007380
database_cross_reference: RCD:ByuFD
database_cross_reference: RCDSY:ByuFD
database_cross_reference: SNOMEDCT_US:190185006

cerebral amyloid angiopathy
type: Class
subclass of: amyloidosis
PMOID: PMO:00028848
Subclass_of: amyloidosis
Synonym: Amyloid Angiopathy, Cerebral
Synonym: Angiopathy, Cerebral Amyloid
Synonym: Angiopathy, Congophilic
Synonym: CAA - Cerebral amyloid angiopathy
Synonym: CAA-Cerebr amyloid angiopath
Synonym: Cerebral Amyloid Angiopathies
Synonym: Cerebral Amyloid Angiopathy
Synonym: Cerebral Amyloid Angiopathy [Disease/Finding]
Synonym: Cerebral amyloid angiopathy
Synonym: Cerebral amyloid angiopathy (disorder)
Tree Number: T10.6.1.2.6
database_cross_reference: CHV:0000015504
database_cross_reference: HPO:HP:0011970
database_cross_reference: ICD10:I68.0
database_cross_reference: ICD10AM:I68.0
database_cross_reference: ICD10CM:I68.0
database_cross_reference: MDR:10068044
database_cross_reference: MEDCIN:32182
database_cross_reference: MSH:D016657
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84625
database_cross_reference: NDFRT:N0000003453
database_cross_reference: OMIM:MTHU038754
database_cross_reference: RCD:X00Do
database_cross_reference: SNOMEDCT_US:195228000
database_cross_reference: SNOMEDCT_US:230724001

Pallister-Hall syndrome
type: Class
subclass of: physical disorder
PMOID: PMO:00028268
Subclass_of: physical disorder
Synonym: CAVE Complex
Synonym: CAVE Complices
Synonym: Cerebroacrovisceral Early Lethality Complex
Synonym: Complex, CAVE
Synonym: Complices, CAVE
Synonym: HYPOTHALAMIC HAMARTOBLASTOMA, HYPOPITUITARISM, IMPERFORATE ANUS, AND POSTAXIAL POLYDACTYLY
Synonym: Hall Pallister Syndrome
Synonym: Hall syndrome 2
Synonym: Hall-Pallister Syndrome
Synonym: Hamartoblastoma Syndrome, Hypothalamic
Tree Number: T10.4.14
database_cross_reference: CHV:0000025855
database_cross_reference: DO:DOID:9248
database_cross_reference: JABL:521
database_cross_reference: MSH:D054975
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84987
database_cross_reference: NDFRT:N0000181083
database_cross_reference: OMIM:146510
database_cross_reference: OMIM:165240
database_cross_reference: SNMI:D4-00611
database_cross_reference: SNOMEDCT_US:56677004

Beemer-Langer syndrome
type: Class
subclass of: syndrome
definition: A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly.
PMOID: PMO:00025238
Subclass_of: syndrome
Synonym: BEEMER-LANGER SYNDROME
Synonym: Beemer Langer syndrome
Synonym: Beemer-Langer Syndrome
Synonym: Beemer-Langer sh rib polydact
Synonym: Beemer-Langer type short rib polydactyly syndrome
Synonym: SHORT RIB SYNDROME, BEEMER TYPE
Synonym: SHORT RIB-POLYDACTYLY SYNDROME, TYPE IV
Synonym: SHORT-RIB THORACIC DYSPLASIA 12
Synonym: SRPS IV
Synonym: SRPS, type 4
Tree Number: T10.1.98
database_cross_reference: DO:DOID:9249
database_cross_reference: MSH:C537599
database_cross_reference: OMIM:269860
database_cross_reference: RCD:X789d
database_cross_reference: SNOMEDCT_US:254052001

acrocallosal syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation.
PMOID: PMO:00025248
Subclass_of: syndrome
Synonym: ACLS
Synonym: ACROCALLOSAL SYNDROME
Synonym: Acrocallosal Syndrome
Synonym: Acrocallosal Syndrome [Disease/Finding]
Synonym: Acrocallosal Syndromes
Synonym: Acrocallosal syndrome
Synonym: Acrocallosal syndrome (disorder)
Synonym: HALLUX DUPLICATION, POSTAXIAL POLYDACTYLY, AND ABSENCE OF CORPUS CALLOSUM
Synonym: Hallux Duplication, Postaxial Polydactyly, and Absence of Corpus Callosum
Synonym: SCHINZEL ACROCALLOSAL SYNDROME
Tree Number: T10.1.108
database_cross_reference: CHV:0000048962
database_cross_reference: DO:DOID:9250
database_cross_reference: JABL:577
database_cross_reference: MSH:D055673
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84531
database_cross_reference: NDFRT:N0000181177
database_cross_reference: OMIM:200990
database_cross_reference: OMIM:611254
database_cross_reference: SNOMEDCT_US:715951007

amino acid metabolic disorder
type: Class
subclass of: inherited metabolic disorder
definition: An inherited metabolic disorder that is characterized by impaired synthesis and degradation of amino acids.
PMOID: PMO:00029166
Subclass_of: inherited metabolic disorder
Synonym: AA METAB DIS INBORN
Synonym: AA METAB INBORN ERR
Synonym: AMINO ACIDOPATHIES CONGEN
Synonym: AMINOACIDOPATHY
Synonym: Amino Acid Metabolism Disorder
Synonym: Amino Acid Metabolism Disorders
Synonym: Amino Acid Metabolism Disorders, Inborn
Synonym: Amino Acid Metabolism, Inborn Error
Synonym: Amino Acid Metabolism, Inborn Errors
Synonym: Amino Acid Metabolism, Inborn Errors [Disease/Finding]
Tree Number: T10.6.2.15
database_cross_reference: AOD:0000005735
database_cross_reference: AOD:0000023430
database_cross_reference: CHV:0000001006
database_cross_reference: CHV:0000024664
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-0342
database_cross_reference: DO:DOID:9252
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000931
database_cross_reference: ICD10:E72.9
database_cross_reference: ICD10AM:E72.9
database_cross_reference: ICD10CM:E72.9
database_cross_reference: ICD9CM:270
database_cross_reference: ICD9CM:270.9
database_cross_reference: ICPC2P:T99005
database_cross_reference: LCH:U000192
database_cross_reference: LCH_NW:sh85004483
database_cross_reference: MDR:10001938
database_cross_reference: MDR:10013294
database_cross_reference: MDR:10021602
database_cross_reference: MDR:10045768
database_cross_reference: MDR:10045769
database_cross_reference: MEDCIN:99882
database_cross_reference: MEDLINEPLUS:6385
database_cross_reference: MSH:D000592
database_cross_reference: NCI:C97090
database_cross_reference: NCI_NICHD:C97090
database_cross_reference: NDFRT:N0000000369
database_cross_reference: RCD:C30..
database_cross_reference: RCD:C30z.
database_cross_reference: SNM:D-1600
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D6-A0000
database_cross_reference: SNMI:D6-A0100
database_cross_reference: SNOMEDCT_US:154734005
database_cross_reference: SNOMEDCT_US:190680002
database_cross_reference: SNOMEDCT_US:190740001
database_cross_reference: SNOMEDCT_US:267496003
database_cross_reference: SNOMEDCT_US:42930003
database_cross_reference: SNOMEDCT_US:44779003

homocystinuria
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves an accumulation of homocysteine in the serum and an increased excretion of homocysteine in the urine.
PMOID: PMO:00029187
Subclass_of: amino acid metabolic disorder
Synonym: CBS deficiency
Synonym: Cystathionine synthase deficiency
Synonym: HCY
Synonym: HOMOCYSTINURIA
Synonym: High urine homocystine levels
Synonym: Homocystinuria
Synonym: Homocystinuria (disorder)
Synonym: Homocystinuria [Ambiguous]
Synonym: Homocystinuria [Disease/Finding]
Synonym: Homocystinuria, NOS
Tree Number: T10.6.2.15.10
database_cross_reference: CCPSS:0019687
database_cross_reference: CHV:0000006228
database_cross_reference: CSP:1849-0835
database_cross_reference: DO:DOID:9263
database_cross_reference: DXP:U000854
database_cross_reference: DXP:U001986
database_cross_reference: HPO:HP:0002156
database_cross_reference: ICD10CM:E72.11
database_cross_reference: ICPC2P:T99073
database_cross_reference: LNC:LA12496-8
database_cross_reference: LNC:LP56981-1
database_cross_reference: MDR:10020365
database_cross_reference: MEDCIN:33524
database_cross_reference: MSH:D006712
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:270.4
database_cross_reference: NCI:C84765
database_cross_reference: NCI_NICHD:C84765
database_cross_reference: NDFRT:N0000001552
database_cross_reference: OMIM:MTHU037510
database_cross_reference: RCD:C3043
database_cross_reference: SNM:D-1681
database_cross_reference: SNMI:D6-B4100
database_cross_reference: SNOMEDCT_US:11282001
database_cross_reference: SNOMEDCT_US:190709008

histidine metabolism disease
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves deficiency in histidine.
PMOID: PMO:00029188
Subclass_of: amino acid metabolic disorder
Synonym: Dis histidine metabolism
Synonym: Disord of histidine metabolism
Synonym: Disorder of histidine metabolism
Synonym: Disorder of histidine metabolism (disorder)
Synonym: Disorder of histidine metabolism, NOS
Synonym: Disorders of histidine metabolism
Synonym: Disorders of histidine metabolism, unspecified
Synonym: Disturbance of histidine metabolism NOS
Synonym: Disturbance of histidine metabolism NOS (disorder)
Synonym: Disturbances of histidine metabolism
Tree Number: T10.6.2.15.11
database_cross_reference: DO:DOID:9265
database_cross_reference: ICD10CM:E70.4
database_cross_reference: ICD10CM:E70.40
database_cross_reference: ICD9CM:270.5
database_cross_reference: MDR:10013515
database_cross_reference: MEDCIN:315379
database_cross_reference: RCD:C305.
database_cross_reference: RCD:C305z
database_cross_reference: SNMI:D6-A3100
database_cross_reference: SNOMEDCT_US:190715008
database_cross_reference: SNOMEDCT_US:44176004

cystinuria
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves the formation of cystine stones in the kidneys, ureter, and bladder.
PMOID: PMO:00029229
Subclass_of: amino acid metabolic disorder
Synonym: CSNU
Synonym: CSNU - Cystinuria
Synonym: CSNU1, FORMERLY
Synonym: CSNU3, FORMERLY
Synonym: CYSTINURIA
Synonym: CYSTINURIA, TYPE I, FORMERLY
Synonym: CYSTINURIA, TYPE II, FORMERLY
Synonym: CYSTINURIA, TYPE III, FORMERLY
Synonym: CYSTINURIA, TYPE NON-I, FORMERLY
Synonym: Cystinuria
Tree Number: T10.6.2.15.28
database_cross_reference: AOD:0000005737
database_cross_reference: CHV:0000003557
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-2146
database_cross_reference: DO:DOID:9266
database_cross_reference: DXP:U000432
database_cross_reference: HPO:HP:0003131
database_cross_reference: ICD10CM:E72.01
database_cross_reference: ICPC2P:T99072
database_cross_reference: LCH:U001245
database_cross_reference: LCH_NW:sh85035213
database_cross_reference: MDR:10011778
database_cross_reference: MEDCIN:30654
database_cross_reference: MSH:D003555
database_cross_reference: MTHICD9:270.0
database_cross_reference: NCI:C84664
database_cross_reference: NDFRT:N0000000893
database_cross_reference: OMIM:104614
database_cross_reference: OMIM:220100
database_cross_reference: OMIM:604144
database_cross_reference: RCD:C3001
database_cross_reference: SNM:D-6633
database_cross_reference: SNMI:D6-B8200
database_cross_reference: SNOMEDCT_US:154738008
database_cross_reference: SNOMEDCT_US:267498002
database_cross_reference: SNOMEDCT_US:85020001

urea cycle disorder
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves a deficiency of one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream.
PMOID: PMO:00029167
Subclass_of: amino acid metabolic disorder
Synonym: 6-A5 DISORDERS OF THE UREA CYCLE METABOLISM
Synonym: DISORDERS OF THE UREA CYCLE METABOLISM
Synonym: Dis urea cycle metabol
Synonym: Disorder of Urea Cycle Metabolism
Synonym: Disorder of the urea cycle metabolism
Synonym: Disorder of the urea cycle metabolism (disorder)
Synonym: Disorder of the urea cycle metabolism, NOS
Synonym: Disorder of urea cycle
Synonym: Disorder of urea cycle metabolism, unspecified
Synonym: Disorder, Urea Cycle
Tree Number: T10.6.2.15.1
database_cross_reference: CHV:0000017387
database_cross_reference: CSP:1849-9321
database_cross_reference: DO:DOID:9267
database_cross_reference: ICD10:E72.2
database_cross_reference: ICD10AM:E72.2
database_cross_reference: ICD10CM:E72.2
database_cross_reference: ICD10CM:E72.20
database_cross_reference: ICD9CM:270.6
database_cross_reference: MDR:10013373
database_cross_reference: MSH:D056806
database_cross_reference: MTHICD9:270.6
database_cross_reference: NCI:C84785
database_cross_reference: NCI_NICHD:C84785
database_cross_reference: NDFRT:N0000181054
database_cross_reference: RCD:C306.
database_cross_reference: SNMI:D6-A5000
database_cross_reference: SNOMEDCT_US:36444000

glycine encephalopathy
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves abnormally high levels of the amino acid glycine in bodily fluids and tissues.
PMOID: PMO:00029220
Subclass_of: amino acid metabolic disorder
Synonym: Dis of glycine cleav enz compl
Synonym: Disorder of glycine cleavage enzyme complex
Synonym: Encephalopathies, Glycine
Synonym: Encephalopathy, Glycine
Synonym: GCE
Synonym: GLYCINE ENCEPHALOPATHY
Synonym: Glycine Encephalopathies
Synonym: Glycine Encephalopathy
Synonym: HYPERGLYCINEMIA, NONKETOTIC
Synonym: Hyperglycinemia, Non-ketotic
Tree Number: T10.6.2.15.22
database_cross_reference: CHV:0000048484
database_cross_reference: CSP:1849-0664
database_cross_reference: DO:DOID:9268
database_cross_reference: HPO:HP:0008288
database_cross_reference: ICD10CM:E72.51
database_cross_reference: MDR:10070639
database_cross_reference: MDR:10070641
database_cross_reference: MEDCIN:315400
database_cross_reference: MSH:D020158
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84937
database_cross_reference: NCI_NICHD:C84937
database_cross_reference: NDFRT:N0000004011
database_cross_reference: OMIM:238300
database_cross_reference: OMIM:238310
database_cross_reference: OMIM:238330
database_cross_reference: OMIM:605899
database_cross_reference: RCD:X40Sf
database_cross_reference: RCDAE:X40Sf
database_cross_reference: SNM:D-1692
database_cross_reference: SNOMEDCT_US:237939006

alkaptonuria
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves phenylalanine and tyrosine metabolism with the accumulation of homogentisic acid, a toxic tyrosine byproduct.
PMOID: PMO:00029198
Subclass_of: amino acid metabolic disorder
Synonym: AKU
Synonym: ALCAPTONURIA
Synonym: ALKAPTONURIA
Synonym: Alcaptonuria
Synonym: Alcaptonuria (disorder)
Synonym: Alcaptonurias
Synonym: Alkaptonuria
Synonym: Alkaptonuria (disorder)
Synonym: Alkaptonuria (disorder) [Ambiguous]
Synonym: Alkaptonuria (finding)
Tree Number: T10.6.2.15.20
database_cross_reference: AOD:0000005743
database_cross_reference: CHV:0000000903
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:URIN ABNORM
database_cross_reference: DO:DOID:9270
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000067
database_cross_reference: ICD10CM:E70.29
database_cross_reference: MDR:10001689
database_cross_reference: MEDCIN:33532
database_cross_reference: MSH:D000474
database_cross_reference: MTHICD9:270.2
database_cross_reference: NCI:C84546
database_cross_reference: NDFRT:N0000000357
database_cross_reference: OMIM:203500
database_cross_reference: OMIM:607474
database_cross_reference: RCD:XE116
database_cross_reference: SNM:D-1748
database_cross_reference: SNMI:D6-A2180
database_cross_reference: SNOMEDCT_US:124207005
database_cross_reference: SNOMEDCT_US:190689001
database_cross_reference: SNOMEDCT_US:24250001
database_cross_reference: SNOMEDCT_US:267418001
database_cross_reference: SNOMEDCT_US:360378009
database_cross_reference: SNOMEDCT_US:360381004
database_cross_reference: SNOMEDCT_US:367388008

hyperlysinemia
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood.
PMOID: PMO:00029196
Subclass_of: amino acid metabolic disorder
Synonym: Deficiencies, L-Lysine:NAD-Oxido-Reductase
Synonym: Deficiencies, Lysine:Alpha-Ketoglutarate Reductase
Synonym: Deficiency, L-Lysine:NAD-Oxido-Reductase
Synonym: Deficiency, Lysine:Alpha-Ketoglutarate Reductase
Synonym: Elevated blood lysine
Synonym: Familial Hyperlysinemia
Synonym: Familial Hyperlysinemias
Synonym: Hyperlysinaemia
Synonym: Hyperlysinaemia, NOS
Synonym: Hyperlysinemia
Tree Number: T10.6.2.15.18
database_cross_reference: CHV:0000026327
database_cross_reference: CSP:1849-0342
database_cross_reference: DO:DOID:9274
database_cross_reference: HPO:HP:0002161
database_cross_reference: ICD10CM:E72.3
database_cross_reference: MEDCIN:33612
database_cross_reference: MSH:D020167
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:270.7
database_cross_reference: NCI:C123433
database_cross_reference: NDFRT:N0000004016
database_cross_reference: OMIM:MTHU047634
database_cross_reference: RCD:C3074
database_cross_reference: RCDAE:C3074
database_cross_reference: SNM:D-1710
database_cross_reference: SNMI:D6-A6110
database_cross_reference: SNOMEDCT_US:58558003

tyrosinemia
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves impaired break down of the amino acid tyrosine.
PMOID: PMO:00029172
Subclass_of: amino acid metabolic disorder
Synonym: Hereditary Tyrosinemia
Synonym: Hereditary Tyrosinemias
Synonym: Hypertyrosinemia
Synonym: Tyrosinaemia
Synonym: Tyrosinemia
Synonym: Tyrosinemia (disorder)
Synonym: Tyrosinemia, Hereditary
Synonym: Tyrosinemias
Synonym: Tyrosinemias [Disease/Finding]
Synonym: Tyrosinemias, Hereditary
Tree Number: T10.6.2.15.3
database_cross_reference: CHV:0000026314
database_cross_reference: CSP:1849-1291
database_cross_reference: DO:DOID:9275
database_cross_reference: ICD10CM:E70.21
database_cross_reference: LNC:LP56753-4
database_cross_reference: LNC:MTHU021584
database_cross_reference: MDR:10063443
database_cross_reference: MDR:10063446
database_cross_reference: MEDCIN:33609
database_cross_reference: MSH:D020176
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98640
database_cross_reference: NDFRT:N0000004017
database_cross_reference: OMIM:MTHU037988
database_cross_reference: RCD:C3026
database_cross_reference: RCDAE:C3026
database_cross_reference: SNM:D-1620
database_cross_reference: SNOMEDCT_US:190694001

hyperhomocysteinemia
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood.
PMOID: PMO:00029195
Subclass_of: amino acid metabolic disorder
Synonym: HYPERHOMOCYSTEINEMIA
Synonym: Hyperhomocysteinaemia
Synonym: Hyperhomocysteinemia
Synonym: Hyperhomocysteinemia (disorder)
Synonym: Hyperhomocysteinemia [Disease/Finding]
Synonym: Hyperhomocysteinemias
Synonym: hyperhomocysteinaemia
Tree Number: T10.6.2.15.17
database_cross_reference: CHV:0000041917
database_cross_reference: CSP:1849-0835
database_cross_reference: DO:DOID:9279
database_cross_reference: MDR:10051286
database_cross_reference: MDR:10055180
database_cross_reference: MSH:D020138
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84770
database_cross_reference: NCI_NICHD:C84770
database_cross_reference: NDFRT:N0000003996
database_cross_reference: OMIM:603174
database_cross_reference: SNOMEDCT_US:419503008

carbamoyl phosphate synthetase I deficiency disease
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that involves accumulation of ammonia in the blood.
PMOID: PMO:00029228
Subclass_of: amino acid metabolic disorder
Synonym: CAPS deficiency
Synonym: CARBAMOLY PHOSPHATE SYNTHETASE I DEFIC DIS
Synonym: CARBAMOYL PHOSPHATE SYNTHASE AMMONIA DEFIC DIS
Synonym: CARBAMOYL PHOSPHATE SYNTHASE I DEFIC DIS
Synonym: CARBAMOYL PHOSPHATE SYNTHETASE I DEFICIENCY
Synonym: CARBAMOYLPHOSPHATE SYNTHETASE I DEFIC DIS
Synonym: CARBAMYL PHOSPHATE SYNTHETASE DEFIC DIS
Synonym: CARBAMYL PHOSPHATE SYNTHETASE I DEFIC DIS
Synonym: CPS
Synonym: CPS I DEFICIENCY
Tree Number: T10.6.2.15.27
database_cross_reference: CSP:1849-9548
database_cross_reference: DO:DOID:9280
database_cross_reference: LNC:LA12484-4
database_cross_reference: MDR:10058297
database_cross_reference: MDR:10071106
database_cross_reference: MEDCIN:33560
database_cross_reference: MSH:D020165
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84612
database_cross_reference: NCI_NICHD:C84612
database_cross_reference: NDFRT:N0000004015
database_cross_reference: OMIM:237300
database_cross_reference: OMIM:608307

phenylketonuria
type: Class
subclass of: amino acid metabolic disorder
definition: An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional.
PMOID: PMO:00029171
Subclass_of: amino acid metabolic disorder
Synonym: Fï¿½ï¿½lling's disease
Synonym: PHENYLKETONURIA
Synonym: PHENYLKETOURIA
Synonym: PKU
Synonym: PKU (Hereditary Disorder)
Synonym: PKU - Phenylketonuria
Synonym: Phenylalaninaemia
Synonym: Phenylalaninemia
Synonym: Phenylketonuria
Synonym: Phenylketonuria (PKU)
Tree Number: T10.6.2.15.2
database_cross_reference: AOD:0000005742
database_cross_reference: CHV:0000009618
database_cross_reference: CHV:0000058151
database_cross_reference: CSP:1849-1177
database_cross_reference: CSP:1849-1234
database_cross_reference: CST:PHENYLKETONURIA
database_cross_reference: DO:DOID:9281
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001487
database_cross_reference: ICD9CM:270.1
database_cross_reference: ICPC2P:T99023
database_cross_reference: LCH:U003616
database_cross_reference: LCH_NW:sh85100698
database_cross_reference: LNC:LA12520-5
database_cross_reference: LNC:LA21169-0
database_cross_reference: LNC:LP56980-3
database_cross_reference: MDR:10034871
database_cross_reference: MDR:10034872
database_cross_reference: MDR:10034873
database_cross_reference: MDR:10034874
database_cross_reference: MDR:10035118
database_cross_reference: MDR:10060404
database_cross_reference: MEDCIN:32390
database_cross_reference: MEDLINEPLUS:1231
database_cross_reference: MSH:D010661
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:270.1
database_cross_reference: NCI:C81315
database_cross_reference: NCI_NCI-GLOSS:CDR0000446806
database_cross_reference: NCI_NCI-GLOSS:CDR0000458041
database_cross_reference: NCI_NICHD:C81315
database_cross_reference: NDFRT:N0000002389
database_cross_reference: PSY:38230
database_cross_reference: PSY:39000
database_cross_reference: RCD:C301.
database_cross_reference: SNM:D-1640
database_cross_reference: SNMI:D6-A1120
database_cross_reference: SNOMEDCT_US:154735006
database_cross_reference: SNOMEDCT_US:190687004

cleft lip
type: Class
subclass of: orofacial cleft
PMOID: PMO:00028289
Subclass_of: orofacial cleft
Synonym: Cleft lip, unilateral, complete
Synonym: Complete unilateral cleft lip
Synonym: Complete unilateral cleft lip (disorder)
Synonym: Labium leporinum
Synonym: Unilat cleft lip-compl
Synonym: Unilateral complete cleft lip
Synonym: Unilateral complete cleft lip (situation)
Synonym: cheiloschisis
Synonym: cleft lip, unilateral, complete
Synonym: complete unilateral cleft lip
Tree Number: T10.4.21.2
database_cross_reference: DO:DOID:9296
database_cross_reference: ICD9CM:749.11
database_cross_reference: MDR:10009266
database_cross_reference: MEDCIN:37660
database_cross_reference: RCD:P911.
database_cross_reference: SNMI:D4-51401
database_cross_reference: SNOMEDCT_US:62696001

lip disease
type: Class
subclass of: mouth disease
PMOID: PMO:00033737
Subclass_of: mouth disease
Synonym: 5-22 DISEASES OF THE LIPS
Synonym: DISEASES OF THE LIPS
Synonym: Disease of lip
Synonym: Disease of lips
Synonym: Disease of lips (disorder)
Synonym: Disease of lips, NOS
Synonym: Disease, Lip
Synonym: Diseases of lips
Synonym: Diseases of lips NOS
Synonym: Diseases of lips NOS (disorder)
Tree Number: T10.8.11.11.10
database_cross_reference: CHV:0000007447
database_cross_reference: DO:DOID:9297
database_cross_reference: ICD10:K13.0
database_cross_reference: ICD10AM:K13.0
database_cross_reference: ICD10CM:K13.0
database_cross_reference: ICD9CM:528.5
database_cross_reference: MDR:10013124
database_cross_reference: MDR:10024550
database_cross_reference: MDR:10048470
database_cross_reference: MEDCIN:276031
database_cross_reference: MSH:D008047
database_cross_reference: NCI:C26818
database_cross_reference: NDFRT:N0000001846
database_cross_reference: RCD:J085.
database_cross_reference: RCD:J085z
database_cross_reference: SNMI:D5-22000
database_cross_reference: SNOMEDCT_US:196563002
database_cross_reference: SNOMEDCT_US:90678009

monieziasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves zoonotic infection caused by Moniezia expansa, the common tapeworm of sheep.
PMOID: PMO:00029618
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Monieziases
Synonym: Monieziasis
Synonym: Monieziasis [Disease/Finding]
Tree Number: T10.7.4.1.1
database_cross_reference: DO:DOID:931
database_cross_reference: MSH:D008989
database_cross_reference: NDFRT:N0000002025

lymphangitis
type: Class
subclass of: lymphatic system disease
definition: A lymphatic system disease that is characterized by inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. It is caused by Streptococcus pyogenes (Group A strep) or Staphylococcus aureus. Lymphangitis is also sometimes called blood poisoning.
PMOID: PMO:00032940
Subclass_of: lymphatic system disease
Synonym: Inflammation of lymphatics
Synonym: LYMPHANGITIS
Synonym: Lymphangitides
Synonym: Lymphangitis
Synonym: Lymphangitis (disorder)
Synonym: Lymphangitis NOS
Synonym: Lymphangitis [Disease/Finding]
Synonym: Lymphangitis, NOS
Synonym: inflammation lymphatic
Synonym: lymphangitis (diagnosis)
Tree Number: T10.8.6.4.7
database_cross_reference: CCPSS:1002146
database_cross_reference: CHV:0000007600
database_cross_reference: COSTAR:U000426
database_cross_reference: CST:LYMPHANGITIS
database_cross_reference: DO:DOID:9317
database_cross_reference: DXP:U001115
database_cross_reference: DXP:U002463
database_cross_reference: ICD10:I89.1
database_cross_reference: ICD10AM:I89.1
database_cross_reference: ICD10CM:I89.1
database_cross_reference: ICD9CM:457.2
database_cross_reference: ICPC2P:B71006
database_cross_reference: ICPC2P:K99043
database_cross_reference: MDR:10025226
database_cross_reference: MEDCIN:31178
database_cross_reference: MSH:D008205
database_cross_reference: MTHICD9:457.2
database_cross_reference: NCI:C34790
database_cross_reference: NDFRT:N0000001897
database_cross_reference: RCD:G862.
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D3-A0040
database_cross_reference: SNOMEDCT_US:1415005
database_cross_reference: SNOMEDCT_US:266335009

bestiality
type: Class
subclass of: paraphilia disorder
PMOID: PMO:00028154
Subclass_of: paraphilia disorder
Synonym: Bestiality
Synonym: Bestiality (Zoophilia)
Synonym: Bestiality (disorder)
Synonym: Zoophilia
Synonym: bestiality (Zoophilia)
Synonym: zoophilia
Synonym: zoophilia (diagnosis)
Tree Number: T10.3.11.2.3
database_cross_reference: AOD:0000006794
database_cross_reference: AOD:0000006795
database_cross_reference: CHV:0000017209
database_cross_reference: DO:DOID:9336
database_cross_reference: ICD9CM:302.1
database_cross_reference: ICPC2P:P09003
database_cross_reference: MDR:10004492
database_cross_reference: MDR:10048285
database_cross_reference: MEDCIN:32814
database_cross_reference: MTHICD9:302.1
database_cross_reference: RCD:E221.
database_cross_reference: SNM:F-99700
database_cross_reference: SNM:F-99730
database_cross_reference: SNMI:D9-73120
database_cross_reference: SNMI:D9-73260
database_cross_reference: SNOMEDCT_US:154907002
database_cross_reference: SNOMEDCT_US:268763002
database_cross_reference: SNOMEDCT_US:31997002
database_cross_reference: SNOMEDCT_US:81463002

urethral false passage
type: Class
subclass of: urethral disease
PMOID: PMO:00032966
Subclass_of: urethral disease
Synonym: FP - False passage in the urethra
Synonym: FP - False passage in urethra
Synonym: Urethral false passage
Synonym: Urethral false passage (disorder)
Synonym: urethral false passage (diagnosis)
Tree Number: T10.8.7.3.5
database_cross_reference: DO:DOID:9339
database_cross_reference: ICD10CM:N36.5
database_cross_reference: ICD9CM:599.4
database_cross_reference: MDR:10046450
database_cross_reference: MEDCIN:95999
database_cross_reference: RCD:K194.
database_cross_reference: SNMI:D7-23560
database_cross_reference: SNOMEDCT_US:74944002

viral infectious disease
type: Class
subclass of: disease by infectious agent
definition: A disease by infectious agent that results in infection, has material basis in Viruses.
PMOID: PMO:00029346
Subclass_of: disease by infectious agent
Synonym: Disease caused by virus
Synonym: Disease caused by virus, NOS
Synonym: Disease due to virus
Synonym: Disease, Viral
Synonym: Disease, Virus
Synonym: Diseases Caused by Viruses
Synonym: Diseases, Viral
Synonym: Diseases, Virus
Synonym: E-300 VIRAL DISEASES: GENERAL TERMS
Synonym: INFECTION VIRAL
Tree Number: T10.7.2
database_cross_reference: AOD:0000004796
database_cross_reference: AOD:0000023159
database_cross_reference: BI:BI00714
database_cross_reference: CCPSS:0035009
database_cross_reference: CHV:0000013022
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000723
database_cross_reference: CSP:3099-7852
database_cross_reference: CSP:3099-8150
database_cross_reference: CST:INFECT VIRAL
database_cross_reference: DO:DOID:934
database_cross_reference: GO:GO:0016032
database_cross_reference: ICD10:B34
database_cross_reference: ICD10:B34.9
database_cross_reference: ICD10AM:B34
database_cross_reference: ICD10AM:B34.9
database_cross_reference: ICD10CM:B34
database_cross_reference: ICD10CM:B34.9
database_cross_reference: ICPC2P:A77005
database_cross_reference: ICPC2P:A77010
database_cross_reference: LCH:U004960
database_cross_reference: LCH_NW:sh85143818
database_cross_reference: MDR:10021876
database_cross_reference: MDR:10047461
database_cross_reference: MDR:10047463
database_cross_reference: MEDCIN:90185
database_cross_reference: MEDLINEPLUS:454
database_cross_reference: MSH:D014777
database_cross_reference: MTH:789
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:079.99
database_cross_reference: NCI:C3439
database_cross_reference: NCI_FDA:2248
database_cross_reference: NCI_NICHD:C3439
database_cross_reference: NDFRT:N0000003128
database_cross_reference: OMIM:MTHU054517
database_cross_reference: PSY:55780
database_cross_reference: RCD:AyuDG
database_cross_reference: RCD:X70Iu
database_cross_reference: RCD:XE0RZ
database_cross_reference: RCDSY:AyuDG
database_cross_reference: SNM:D-0350
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DE-30000
database_cross_reference: SNOMEDCT_US:154319002
database_cross_reference: SNOMEDCT_US:154372003
database_cross_reference: SNOMEDCT_US:186754003
database_cross_reference: SNOMEDCT_US:187471008
database_cross_reference: SNOMEDCT_US:266116004
database_cross_reference: SNOMEDCT_US:266188005
database_cross_reference: SNOMEDCT_US:34014006

urethral diverticulum
type: Class
subclass of: urethral disease
PMOID: PMO:00032965
Subclass_of: urethral disease
Synonym: URETHRA DIVERTICULUM
Synonym: URETHRA, DIVERTICULUM
Synonym: Urethral Diverticulum
Synonym: Urethral diverticulum
Synonym: Urethral diverticulum (disorder)
Synonym: diverticulum urethral
Synonym: urethra diverticulum
Synonym: urethral diverticulum (diagnosis)
Tree Number: T10.8.7.3.4
database_cross_reference: CCPSS:1013901
database_cross_reference: CHV:0000017278
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:9341
database_cross_reference: DXP:U001960
database_cross_reference: HPO:HP:0008722
database_cross_reference: ICD10:N36.1
database_cross_reference: ICD10AM:N36.1
database_cross_reference: ICD10CM:N36.1
database_cross_reference: ICD9CM:599.2
database_cross_reference: MDR:10046449
database_cross_reference: MEDCIN:34191
database_cross_reference: NCI:C39861
database_cross_reference: RCD:K192.
database_cross_reference: SNM:M-32700
database_cross_reference: SNMI:D7-23540
database_cross_reference: SNOMEDCT_US:90531003

brain disease
type: Class
subclass of: central nervous system disease
definition: A central nervous system disease that is located_in the brain.
PMOID: PMO:00030484
Subclass_of: central nervous system disease
Synonym: BRAIN DIS
Synonym: BRAIN DISORDER (NOS)
Synonym: Brain
Synonym: Brain Disease
Synonym: Brain Diseases
Synonym: Brain Diseases [Disease/Finding]
Synonym: Brain Disorder
Synonym: Brain Disorders
Synonym: Brain condition NOS
Synonym: Brain conditions NOS
Tree Number: T10.8.2.9.9
database_cross_reference: CHV:0000002134
database_cross_reference: CHV:0000032204
database_cross_reference: CSP:0485-0499
database_cross_reference: CST:BRAIN SYND ACUTE
database_cross_reference: CST:NER/CNS/B
database_cross_reference: DO:DOID:936
database_cross_reference: ICD10:G93.9
database_cross_reference: ICD10AM:G93.9
database_cross_reference: ICD10CM:G93.9
database_cross_reference: ICD9CM:348.9
database_cross_reference: LCH_NW:sh85016332
database_cross_reference: MDR:10006119
database_cross_reference: MDR:10006120
database_cross_reference: MDR:10045690
database_cross_reference: MEDCIN:210110
database_cross_reference: MEDCIN:337652
database_cross_reference: MEDLINEPLUS:174
database_cross_reference: MSH:D001927
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C96413
database_cross_reference: NCI_NICHD:C96413
database_cross_reference: NDFRT:N0000000605
database_cross_reference: PSY:06800
database_cross_reference: RCD:F28z.
database_cross_reference: SNMI:DA-00010
database_cross_reference: SNOMEDCT_US:193059005
database_cross_reference: SNOMEDCT_US:81308009

vesiculitis
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029755
Subclass_of: male reproductive system disease
Synonym: SEMINAL VESICULITIS
Synonym: Seminal Vesiculitis
Synonym: Seminal vesiculitis
Synonym: Seminal vesiculitis (disorder)
Synonym: Seminal vesiculitis NOS
Synonym: Seminal vesiculitis NOS (disorder)
Synonym: Seminal vesiculitis unspecif.
Synonym: Seminal vesiculitis unspecified
Synonym: Seminal vesiculitis unspecified (disorder)
Synonym: Spermatocystitis
Tree Number: T10.8.1.3.5
database_cross_reference: CHV:0000012977
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:9365
database_cross_reference: DXP:U001727
database_cross_reference: ICD10CM:N49.0
database_cross_reference: ICD9CM:608.0
database_cross_reference: ICPC2P:Y73001
database_cross_reference: MDR:10039954
database_cross_reference: MEDCIN:34204
database_cross_reference: MTHICD9:608.0
database_cross_reference: RCD:K280.
database_cross_reference: RCD:K2800
database_cross_reference: RCD:K280z
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D7-52010
database_cross_reference: SNOMEDCT_US:155935006
database_cross_reference: SNOMEDCT_US:198043008
database_cross_reference: SNOMEDCT_US:198044002
database_cross_reference: SNOMEDCT_US:27001009

Fuchs' heterochromic uveitis
type: Class
subclass of: syndrome
definition: A syndrome that is a chronic unilateral (or rarely bilateral) iridocyclitis appearing with the triad of heterochromia, predisposition to cataracts and glaucoma, and keratitic percipitates on the posterior corneal surface.
PMOID: PMO:00025164
Subclass_of: syndrome
Synonym: Fuch hetrochrom cyclitis
Synonym: Fuch's Heterochromic iridocyclitis
Synonym: Fuchs uveitis syndrome
Synonym: Fuchs' heterochromic cyclitis
Synonym: Fuchs' heterochromic cyclitis (diagnosis)
Synonym: Fuchs' heterochromic cyclitis (disorder)
Synonym: Fuchs' heterochromic iridocyclitis
Tree Number: T10.1.45
database_cross_reference: DO:DOID:9375
database_cross_reference: ICD10CM:H20.81
database_cross_reference: ICD9CM:364.21
database_cross_reference: MDR:10017406
database_cross_reference: MEDCIN:34042
database_cross_reference: RCD:F4420
database_cross_reference: SNMI:DA-72310
database_cross_reference: SNOMEDCT_US:11226001

croup
type: Class
subclass of: respiratory system disease
definition: A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.
PMOID: PMO:00032505
Subclass_of: respiratory system disease
Synonym: Acute Obstructive Laryngitis
Synonym: Acute laryngotracheobronchitis
Synonym: Acute laryngotracheobronchitis (disorder)
Synonym: Acute obstructive laryngitis [croup]
Synonym: CROUP
Synonym: Croup
Synonym: Croup (disorder)
Synonym: Croup [Disease/Finding]
Synonym: Croup syndrome
Synonym: LARYNGOTRACHEOBRONCHITIS, ACUTE
Tree Number: T10.8.5.3
database_cross_reference: CCPSS:0059159
database_cross_reference: CHV:0000003477
database_cross_reference: COSTAR:213
database_cross_reference: CST:LARYNGITIS
database_cross_reference: DO:DOID:9395
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000907
database_cross_reference: DXP:U001010
database_cross_reference: ICD10:J05.0
database_cross_reference: ICD10AM:J05.0
database_cross_reference: ICD10CM:J05.0
database_cross_reference: ICD9CM:464.4
database_cross_reference: ICPC2P:R77001
database_cross_reference: LCH:U001207
database_cross_reference: LCH_NW:sh85034323
database_cross_reference: MDR:10011415
database_cross_reference: MEDCIN:34102
database_cross_reference: MEDLINEPLUS:6292
database_cross_reference: MSH:D003440
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:464.4
database_cross_reference: NCI:C26735
database_cross_reference: NCI_NICHD:C26735
database_cross_reference: NDFRT:N0000000877
database_cross_reference: RCD:Xa0lW
database_cross_reference: SNM:D-7504
database_cross_reference: SNMI:D2-04160
database_cross_reference: SNOMEDCT_US:155510007
database_cross_reference: SNOMEDCT_US:195702002
database_cross_reference: SNOMEDCT_US:71186008

epiglottitis
type: Class
subclass of: upper respiratory tract disease
definition: An upper respiratory tract disease which involves inflammation of the epiglottis due to infection. Haemophilus influenzae type B is the most common bacterial causative agent, although some cases are attributable to Streptococcus pneumoniae or Streptococcus pyogenes. The infection can cause the epiglottis to either obstruct or completely close off the windpipe. Epiglottitis typically affects children, and is associated with fever, difficulty in swallowing, drooling, hoarseness of voice, and stridor.
PMOID: PMO:00032503
Subclass_of: upper respiratory tract disease
Synonym: EPIGLOTTITIS
Synonym: Epiglottitides
Synonym: Epiglottitis
Synonym: Epiglottitis (disorder)
Synonym: Epiglottitis NOS
Synonym: Epiglottitis [Disease/Finding]
Synonym: Epiglottitis, NOS
Synonym: Supraglottitis
Synonym: acute epiglottitis
Synonym: acute epiglottitis and supraglottitis
Tree Number: T10.8.5.2.13
database_cross_reference: CCPSS:0003928
database_cross_reference: CHV:0000004555
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:9398
database_cross_reference: DXP:U001141
database_cross_reference: ICD10CM:J05.10
database_cross_reference: ICPC2P:R77004
database_cross_reference: ICPC2P:R83012
database_cross_reference: MDR:10015030
database_cross_reference: MDR:10015032
database_cross_reference: MEDCIN:31090
database_cross_reference: MSH:D004826
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C116007
database_cross_reference: NCI_NICHD:C116007
database_cross_reference: NDFRT:N0000001125
database_cross_reference: SNMI:D2-04900
database_cross_reference: SNOMEDCT_US:80384002

epididymitis
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029744
Subclass_of: male reproductive system disease
Synonym: EPIDIDYMITIS
Synonym: Epididymis inflamed
Synonym: Epididymitides
Synonym: Epididymitis
Synonym: Epididymitis (disorder)
Synonym: Epididymitis NOS
Synonym: Epididymitis NOS (disorder)
Synonym: Epididymitis [Disease/Finding]
Synonym: Epididymitis unspecified
Synonym: Epididymitis unspecified (disorder)
Tree Number: T10.8.1.3.2
database_cross_reference: BI:BI00439
database_cross_reference: CCPSS:0054810
database_cross_reference: CHV:0000004551
database_cross_reference: COSTAR:282
database_cross_reference: CSP:2587-6532
database_cross_reference: CST:EPIDIDYMITIS
database_cross_reference: DO:DOID:9402
database_cross_reference: DXP:U001135
database_cross_reference: HPO:HP:0000031
database_cross_reference: ICD10CM:N45.1
database_cross_reference: ICPC2P:Y74002
database_cross_reference: MDR:10015000
database_cross_reference: MDR:10015003
database_cross_reference: MEDCIN:31101
database_cross_reference: MSH:D004823
database_cross_reference: NDFRT:N0000001124
database_cross_reference: OMIM:MTHU038084
database_cross_reference: RCD:K241.
database_cross_reference: RCD:K2412
database_cross_reference: RCD:K241z
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D7-55120
database_cross_reference: SNOMEDCT_US:155914009
database_cross_reference: SNOMEDCT_US:197993007
database_cross_reference: SNOMEDCT_US:197998003
database_cross_reference: SNOMEDCT_US:31070006
database_cross_reference: SNOMEDCT_VET:31070006

hypopituitarism
type: Class
subclass of: pituitary gland disease
definition: A pituitary gland disease characterized by the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland.
PMOID: PMO:00033213
Subclass_of: pituitary gland disease
Synonym: ADENOHYPOPHYSEAL HYPOSECRET
Synonym: ANTERIOR PITUITARY HYPOSECRET SYNDROME
Synonym: Adenohypophyseal Hyposecretion
Synonym: Anterior Pituitary Hyposecretion Syndrome
Synonym: Deficient secretion of one OR more pituitary hormones
Synonym: Deficient secretion of one or more pituitary hormones
Synonym: HYPOPITUITARISM
Synonym: HYPOPITUTITARISM
Synonym: HYPOSECRET ADENOHYPOPHYSEAL
Synonym: HYPOSECRET SYNDROME ANTERIOR PITUITARY
Tree Number: T10.8.8.5.2
database_cross_reference: AOD:0000005978
database_cross_reference: AOD:0000023563
database_cross_reference: CCPSS:0048653
database_cross_reference: CHV:0000006487
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000375
database_cross_reference: CSP:2335-9587
database_cross_reference: CST:PIT ACTIV DEC
database_cross_reference: DO:DOID:9406
database_cross_reference: DXP:U002053
database_cross_reference: HPO:HP:0040075
database_cross_reference: ICD10:E23.0
database_cross_reference: ICD10AM:E23.0
database_cross_reference: ICD10CM:E23.0
database_cross_reference: ICPC2P:T99033
database_cross_reference: MDR:10021066
database_cross_reference: MDR:10021067
database_cross_reference: MDR:10022466
database_cross_reference: MDR:10035093
database_cross_reference: MEDCIN:30497
database_cross_reference: MSH:D007018
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:253.2
database_cross_reference: NCI:C62591
database_cross_reference: NDFRT:N0000001645
database_cross_reference: OMIM:MTHU036880
database_cross_reference: OMIM:MTHU047352
database_cross_reference: PSY:24050
database_cross_reference: RCD:X40Kt
database_cross_reference: RCD:X40Ku
database_cross_reference: SNM:D-2131
database_cross_reference: SNMI:DB-12000
database_cross_reference: SNOMEDCT_US:154703006
database_cross_reference: SNOMEDCT_US:190469009
database_cross_reference: SNOMEDCT_US:237681002
database_cross_reference: SNOMEDCT_US:267482009
database_cross_reference: SNOMEDCT_US:74728003

diabetes insipidus
type: Class
subclass of: kidney disease
PMOID: PMO:00033022
Subclass_of: kidney disease
Synonym: DI
Synonym: DI - Diabetes insipidus
Synonym: DIABETES INSIPIDUS
Synonym: Diabetes Insipidus
Synonym: Diabetes Insipidus [Disease/Finding]
Synonym: Diabetes insipidus
Synonym: Diabetes insipidus (disorder)
Synonym: Diabetes insipidus, NOS
Synonym: diabete insipidus
Tree Number: T10.8.7.9.6
database_cross_reference: CCPSS:0056411
database_cross_reference: CHV:0000003833
database_cross_reference: CHV:0000044128
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-2602
database_cross_reference: CST:DIABETES INSIPID
database_cross_reference: DO:DOID:9409
database_cross_reference: DXP:U000959
database_cross_reference: HPO:HP:0000873
database_cross_reference: ICD10:E23.2
database_cross_reference: ICD10AM:E23.2
database_cross_reference: ICD10CM:E23.2
database_cross_reference: ICD9CM:253.5
database_cross_reference: ICPC2P:T99011
database_cross_reference: MDR:10012599
database_cross_reference: MEDLINEPLUS:3046
database_cross_reference: MSH:D003919
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C43263
database_cross_reference: NCI_NICHD:C43263
database_cross_reference: NDFRT:N0000000949
database_cross_reference: OMIM:MTHU013463
database_cross_reference: PSY:13960
database_cross_reference: RCD:XE10Y
database_cross_reference: SNM:D-2101
database_cross_reference: SNMI:DB-13100
database_cross_reference: SNOMEDCT_US:15771004
database_cross_reference: SNOMEDCT_US:190484000

lipid storage disease
type: Class
subclass of: lysosomal storage disease
definition: A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues.
PMOID: PMO:00029061
Subclass_of: lysosomal storage disease
Synonym: LIPIDOSIS
Synonym: Lipid storage disease
Synonym: Lipid storage disease (disorder)
Synonym: Lipid storage disease, NOS
Synonym: Lipid storage disorder, unspecified
Synonym: Lipidoses
Synonym: Lipidoses (disorder)
Synonym: Lipidoses NOS
Synonym: Lipidoses NOS (disorder)
Synonym: Lipidoses [Disease/Finding]
Tree Number: T10.6.2.8.6
database_cross_reference: CHV:0000007461
database_cross_reference: CSP:1849-5707
database_cross_reference: CST:ANOMALY CONGEN
database_cross_reference: DO:DOID:9455
database_cross_reference: ICD10:E75.6
database_cross_reference: ICD10AM:E75.6
database_cross_reference: ICD10CM:E75.6
database_cross_reference: ICD9CM:272.7
database_cross_reference: ICPC2P:T93009
database_cross_reference: LCH_NW:sh85077295
database_cross_reference: MDR:10024584
database_cross_reference: MDR:10024585
database_cross_reference: MDR:10024586
database_cross_reference: MDR:10049284
database_cross_reference: MSH:D008064
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:272.7
database_cross_reference: NDFRT:N0000001852
database_cross_reference: RCD:XE11Y
database_cross_reference: RCD:XE11Z
database_cross_reference: SNM:D-1400
database_cross_reference: SNMI:D6-60060
database_cross_reference: SNMI:D6-72000
database_cross_reference: SNOMEDCT_US:10741005
database_cross_reference: SNOMEDCT_US:11455007
database_cross_reference: SNOMEDCT_US:190792005
database_cross_reference: SNOMEDCT_US:190797004
database_cross_reference: SNOMEDCT_US:267437005
database_cross_reference: SNOMEDCT_US:267438000

dientamoebiasis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that involves infection of the large intestine by a protozoan parasite Dientamoeba fragilis. The symptoms include diarrhea, stomach pain and cramping, loss of appetite and weight, nausea, and fatigue.
PMOID: PMO:00029681
Subclass_of: parasitic protozoa infectious disease
Synonym: Dientamoebiases
Synonym: Dientamoebiasis
Synonym: Dientamoebiasis [Disease/Finding]
Synonym: intestinal trichomoniasis
Tree Number: T10.7.4.2.3
database_cross_reference: DO:DOID:946
database_cross_reference: MSH:D004030
database_cross_reference: NDFRT:N0000000969

meningitis
type: Class
subclass of: central nervous system disease
definition: A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.
PMOID: PMO:00030465
Subclass_of: central nervous system disease
Synonym: Inflammation of meninges
Synonym: MENINGITIS
Synonym: Meningitides
Synonym: Meningitis
Synonym: Meningitis (disorder)
Synonym: Meningitis - unspecified cause
Synonym: Meningitis NOS
Synonym: Meningitis [Disease/Finding]
Synonym: Meningitis of unspecified cause
Synonym: Meningitis of unspecified cause (disorder)
Tree Number: T10.8.2.9.6
database_cross_reference: AOD:0000006185
database_cross_reference: BI:BI00546
database_cross_reference: CCPSS:1018016
database_cross_reference: CHV:0000007932
database_cross_reference: COSTAR:478
database_cross_reference: CSP:2042-5301
database_cross_reference: CST:MENINGITIS
database_cross_reference: DO:DOID:9471
database_cross_reference: DXP:U002543
database_cross_reference: HPO:HP:0001287
database_cross_reference: ICD10:G03.9
database_cross_reference: ICD10AM:G03.9
database_cross_reference: ICD10CM:G03
database_cross_reference: ICD10CM:G03.9
database_cross_reference: ICD9CM:322
database_cross_reference: ICD9CM:322.9
database_cross_reference: ICPC2P:N71002
database_cross_reference: LCH:U002901
database_cross_reference: LCH_NW:sh85083562
database_cross_reference: LNC:LA7454-7
database_cross_reference: LNC:LP20756-0
database_cross_reference: MDR:10027199
database_cross_reference: MDR:10027251
database_cross_reference: MDR:10027252
database_cross_reference: MDR:10027263
database_cross_reference: MEDCIN:31192
database_cross_reference: MEDLINEPLUS:324
database_cross_reference: MSH:D008581
database_cross_reference: NCI:C26828
database_cross_reference: NCI_CTCAE:E11458
database_cross_reference: NCI_FDA:2389
database_cross_reference: NCI_NCI-GLOSS:CDR0000471780
database_cross_reference: NCI_NICHD:C26828
database_cross_reference: NDFRT:N0000001981
database_cross_reference: OMIM:MTHU005994
database_cross_reference: PSY:30660
database_cross_reference: RCD:F02..
database_cross_reference: RCD:F02z.
database_cross_reference: RCD:X000H
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:DA-10010
database_cross_reference: SNOMEDCT_US:154983000
database_cross_reference: SNOMEDCT_US:192678004
database_cross_reference: SNOMEDCT_US:192681009
database_cross_reference: SNOMEDCT_US:7180009
database_cross_reference: SNOMEDCT_VET:7180009

Meckel's diverticulum
type: Class
subclass of: physical disorder
PMOID: PMO:00028257
Subclass_of: physical disorder
Synonym: (Meckel's diverticulum) or (persistent omphalomesenteric duct) or (persistent vitelline duct)
Synonym: (Meckel's diverticulum) or (persistent omphalomesenteric duct) or (persistent vitelline duct) (disorder)
Synonym: (Persistent omphalomesenteric duct) or (persistent vitelline duct)
Synonym: (Persistent omphalomesenteric duct) or (persistent vitelline duct) (disorder)
Synonym: Diverticulum Meckel's
Synonym: Diverticulum ilei
Synonym: Diverticulum of Meckel
Synonym: Diverticulum, Meckel
Synonym: ILEAL DIVERTICULA
Synonym: Ileal diverticulum
Tree Number: T10.4.3
database_cross_reference: AOD:0000005616
database_cross_reference: CCPSS:0054703
database_cross_reference: CCPSS:1003737
database_cross_reference: CHV:0000007828
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:9487
database_cross_reference: DXP:U001144
database_cross_reference: FMA:14967
database_cross_reference: HPO:HP:0002245
database_cross_reference: ICD10:Q43.0
database_cross_reference: ICD10AM:Q43.0
database_cross_reference: ICD10CM:Q43.0
database_cross_reference: ICD9CM:751.0
database_cross_reference: ICPC2P:D81003
database_cross_reference: ICPC2P:D81013
database_cross_reference: ICPC2P:D92004
database_cross_reference: LNC:LP208999-5
database_cross_reference: MDR:10013561
database_cross_reference: MDR:10027055
database_cross_reference: MEDCIN:30072
database_cross_reference: MEDCIN:35842
database_cross_reference: MSH:D008467
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:751.0
database_cross_reference: NCI:C12264
database_cross_reference: NCI_NICHD:C12264
database_cross_reference: NDFRT:N0000001957
database_cross_reference: OMIM:155140
database_cross_reference: OMIM:MTHU005288
database_cross_reference: RCD:PB00.
database_cross_reference: RCD:PB0z.
database_cross_reference: RCD:X783W
database_cross_reference: RCD:XE1Kp
database_cross_reference: SNM:M-21400
database_cross_reference: SNM:T-65600
database_cross_reference: SNMI:D4-56144
database_cross_reference: SNOMEDCT_US:127962001
database_cross_reference: SNOMEDCT_US:156955000
database_cross_reference: SNOMEDCT_US:204685004
database_cross_reference: SNOMEDCT_US:204686003
database_cross_reference: SNOMEDCT_US:204689005
database_cross_reference: SNOMEDCT_US:204690001
database_cross_reference: SNOMEDCT_US:253775007
database_cross_reference: SNOMEDCT_US:264256006
database_cross_reference: SNOMEDCT_US:37373007
database_cross_reference: UWDA:14967

leukocyte disease
type: Class
subclass of: hematopoietic system disease
PMOID: PMO:00033393
Subclass_of: hematopoietic system disease
Synonym: C-40 WHITE BLOOD CELL DISORDERS: GENERAL TERMS
Synonym: Disease of white blood cells, unspecified
Synonym: Diseases of white blood cells
Synonym: Disorder of white blood cells, unspecified
Synonym: Disorder, Leukocyte
Synonym: Disorders, Leukocyte
Synonym: LEUKOCYTE DIS
Synonym: Leucocyte disorders
Synonym: Leukocyte Disorder
Synonym: Leukocyte Disorders
Tree Number: T10.8.10.6
database_cross_reference: AOD:0000005919
database_cross_reference: CHV:0000007359
database_cross_reference: CSP:0427-6022
database_cross_reference: DO:DOID:9500
database_cross_reference: ICD10:D72.9
database_cross_reference: ICD10AM:D72.9
database_cross_reference: ICD10CM:D72.9
database_cross_reference: ICD9CM:288
database_cross_reference: ICD9CM:288.9
database_cross_reference: LCH_NW:sh85076268
database_cross_reference: MDR:10013112
database_cross_reference: MDR:10013139
database_cross_reference: MDR:10045761
database_cross_reference: MDR:10047953
database_cross_reference: MDR:10047954
database_cross_reference: MDR:10061414
database_cross_reference: MEDCIN:99905
database_cross_reference: MSH:D007960
database_cross_reference: NDFRT:N0000001831
database_cross_reference: RCD:D40..
database_cross_reference: RCD:D40z.
database_cross_reference: SNM:D-4340
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DC-40000
database_cross_reference: SNOMEDCT_US:154829002
database_cross_reference: SNOMEDCT_US:191369001
database_cross_reference: SNOMEDCT_US:54097007

cannabis abuse
type: Class
subclass of: substance abuse
definition: A substance abuse that involves the recurring use of cannabis despite negative consequences.
PMOID: PMO:00027914
Subclass_of: substance abuse
Synonym: Abuse;drug(s);non dependent
Synonym: Drug abuse, not dependent
Synonym: Drug misuse non-depend.
Synonym: Non dependent drug abuse
Synonym: Non dependent drug abuse (disorder)
Synonym: Non-dependent abuse of drugs
Synonym: Nondependent misuse of drugs
Synonym: drug abuse (not dependent)
Synonym: marijuana abuse
Tree Number: T10.3.3.2.2
database_cross_reference: DO:DOID:9505
database_cross_reference: ICPC2P:P19006
database_cross_reference: SNM:F-Y0300
database_cross_reference: SNMI:DF-10204
database_cross_reference: SNOMEDCT_US:268769003
database_cross_reference: SNOMEDCT_US:49540005

Lassa fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.
PMOID: PMO:00029392
Subclass_of: viral infectious disease
Synonym: Fever, Lassa
Synonym: Fevers, Lassa
Synonym: LASSA FEVER
Synonym: Lassa Fever
Synonym: Lassa Fever [Disease/Finding]
Synonym: Lassa Fevers
Synonym: Lassa fever (diagnosis)
Synonym: Lassa fever (disorder)
Synonym: Lassa hemorrhagic fever
Synonym: fever lassa
Tree Number: T10.7.2.36
database_cross_reference: CHV:0000007236
database_cross_reference: DO:DOID:9537
database_cross_reference: DXP:U001022
database_cross_reference: ICD10:A96.2
database_cross_reference: ICD10AM:A96.2
database_cross_reference: ICD10CM:A96.2
database_cross_reference: LCH:U002627
database_cross_reference: LCH_NW:sh85074820
database_cross_reference: LNC:LA10481-2
database_cross_reference: MDR:10023927
database_cross_reference: MEDCIN:31172
database_cross_reference: MEDLINEPLUS:1652
database_cross_reference: MSH:D007835
database_cross_reference: NCI:C128418
database_cross_reference: NCI_NICHD:C128418
database_cross_reference: NDFRT:N0000001788
database_cross_reference: RCD:A78y5
database_cross_reference: SNM:D-0423
database_cross_reference: SNMI:DE-34A30
database_cross_reference: SNOMEDCT_US:19065005

vascular skin disease
type: Class
subclass of: skin disease
PMOID: PMO:00033982
Subclass_of: skin disease
Synonym: Dis blood vessels affect skin
Synonym: Disease, Vascular Skin
Synonym: Diseases, Vascular Skin
Synonym: Disorder of blood vessels affecting skin
Synonym: SECTION 0-3 VASCULAR DISEASES OF THE SKIN
Synonym: SKIN DIS VASCULAR
Synonym: Skin Disease, Vascular
Synonym: Skin Diseases, Vascular
Synonym: Skin Diseases, Vascular [Disease/Finding]
Synonym: Skin Vascular Disorder
Tree Number: T10.8.12.2.46
database_cross_reference: DO:DOID:9540
database_cross_reference: HPO:HP:0011276
database_cross_reference: ICD9CM:709.1
database_cross_reference: MDR:10047043
database_cross_reference: MDR:10047072
database_cross_reference: MDR:10047109
database_cross_reference: MDR:10062171
database_cross_reference: MEDCIN:355710
database_cross_reference: MSH:D017445
database_cross_reference: NCI:C35254
database_cross_reference: NDFRT:N0000003578
database_cross_reference: RCD:M2y0.
database_cross_reference: RCD:XE1BV
database_cross_reference: SNMI:D0-30000
database_cross_reference: SNOMEDCT_US:11263005
database_cross_reference: SNOMEDCT_US:201306008
database_cross_reference: SNOMEDCT_US:267820009

adrenal gland disease
type: Class
subclass of: endocrine system disease
definition: An endocrine system disease that is located_in the adrenal gland.
PMOID: PMO:00033228
Subclass_of: endocrine system disease
Synonym: ADRENAL DISEASE, NOS
Synonym: ADRENAL DISORDER
Synonym: ADRENAL GLAND DIS
Synonym: Adrenal Disease
Synonym: Adrenal Gland Disease
Synonym: Adrenal Gland Diseases
Synonym: Adrenal Gland Diseases [Disease/Finding]
Synonym: Adrenal Gland Disorder
Synonym: Adrenal Gland Disorders
Synonym: Adrenal disease
Tree Number: T10.8.8.6
database_cross_reference: AOD:0000006000
database_cross_reference: CCPSS:0062779
database_cross_reference: CHV:0000000764
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000085
database_cross_reference: CSP:0060-3106
database_cross_reference: CST:ADREN DIS
database_cross_reference: DO:DOID:9553
database_cross_reference: HPO:HP:0000834
database_cross_reference: ICD10:E27.9
database_cross_reference: ICD10AM:E27.9
database_cross_reference: ICD10CM:E27.9
database_cross_reference: ICD9CM:255
database_cross_reference: ICD9CM:255.9
database_cross_reference: LCH_NW:sh85001000
database_cross_reference: MDR:10001347
database_cross_reference: MDR:10001348
database_cross_reference: MDR:10001353
database_cross_reference: MDR:10013186
database_cross_reference: MDR:10013293
database_cross_reference: MDR:10045767
database_cross_reference: MDR:10045839
database_cross_reference: MEDCIN:90719
database_cross_reference: MEDLINEPLUS:128
database_cross_reference: MSH:D000307
database_cross_reference: NCI:C26690
database_cross_reference: NDFRT:N0000000324
database_cross_reference: PSY:01010
database_cross_reference: RCD:C15..
database_cross_reference: RCD:C15z.
database_cross_reference: SNM:D-2300
database_cross_reference: SNM:U000004
database_cross_reference: SNMI:DB-70000
database_cross_reference: SNOMEDCT_US:154704000
database_cross_reference: SNOMEDCT_US:190532009
database_cross_reference: SNOMEDCT_US:30171000

nasopharyngeal disease
type: Class
subclass of: upper respiratory tract disease
PMOID: PMO:00032499
Subclass_of: upper respiratory tract disease
Synonym: Disease of nasopharynx
Synonym: Disease of nasopharynx (disorder)
Synonym: Disease, Nasopharyngeal
Synonym: Diseases of Nasopharynx
Synonym: Diseases, Nasopharyngeal
Synonym: Disorder of PNS - postnasal space
Synonym: Disorder of PNS-postnas space
Synonym: Disorder of nasopharynx
Synonym: Disorder of nasopharynx (disorder)
Synonym: Disorder of postnasal space
Tree Number: T10.8.5.2.10
database_cross_reference: CST:RES/NASP
database_cross_reference: DO:DOID:9561
database_cross_reference: LCH_NW:sh85089898
database_cross_reference: MDR:10057538
database_cross_reference: MEDCIN:355020
database_cross_reference: MSH:D009302
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35723
database_cross_reference: NDFRT:N0000002111
database_cross_reference: RCD:X00lW
database_cross_reference: SNOMEDCT_US:123952009

primary ciliary dyskinesia
type: Class
subclass of: ciliopathy
definition: A ciliopathy that is characterized by impaired function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube.
PMOID: PMO:00028334
Subclass_of: ciliopathy
Synonym: CILIARY MOTILITY DIS
Synonym: Cilia Syndrome, Immotile
Synonym: Cilia Syndromes, Immotile
Synonym: Ciliary Dyskinesia
Synonym: Ciliary Dyskinesias
Synonym: Ciliary Motility Defect
Synonym: Ciliary Motility Disorder
Synonym: Ciliary Motility Disorders
Synonym: Ciliary Motility Disorders [Disease/Finding]
Synonym: Ciliary dyskinesia
Tree Number: T10.5.1.3
database_cross_reference: CHV:0000002992
database_cross_reference: DO:DOID:9562
database_cross_reference: HPO:HP:0012265
database_cross_reference: MDR:10060882
database_cross_reference: MDR:10069713
database_cross_reference: MEDCIN:313146
database_cross_reference: MSH:D002925
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84638
database_cross_reference: NCI_NICHD:C84638
database_cross_reference: NDFRT:N0000000791
database_cross_reference: RCD:X101Z
database_cross_reference: SNM:D-7715
database_cross_reference: SNMI:D4-01515
database_cross_reference: SNOMEDCT_US:86204009
database_cross_reference: SNOMEDCT_US:9057007

Venezuelan equine encephalitis
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.
PMOID: PMO:00029423
Subclass_of: viral infectious disease
Synonym: Disorder caused by Venezuelan equine encephalitis virus
Synonym: Disorder caused by Venezuelan equine encephalitis virus (disorder)
Synonym: Disorder due to Venezuelan equine encephalitis virus
Synonym: Disorder due to Venezuelan equine encephalitis virus (disorder)
Synonym: ENCEPH VENEZUELAN EQUINE
Synonym: EQUINE ENCEPH VENEZUELAN
Synonym: Encephalitis venezuelan equine
Synonym: Encephalitis, Venezuelan Equine
Synonym: Encephalomyelitides, Venezuelan Equine
Synonym: Encephalomyelitis, Venezuelan Equine
Tree Number: T10.7.2.57
database_cross_reference: CHV:0000004430
database_cross_reference: DO:DOID:9584
database_cross_reference: ICD10:A92.2
database_cross_reference: ICD10AM:A92.2
database_cross_reference: ICD10CM:A92.2
database_cross_reference: ICD9CM:066.2
database_cross_reference: LCH:U004916
database_cross_reference: LCH_NW:sh85142697
database_cross_reference: MDR:10014611
database_cross_reference: MDR:10047177
database_cross_reference: MDR:10047204
database_cross_reference: MDR:10047205
database_cross_reference: MDR:10047206
database_cross_reference: MEDCIN:30859
database_cross_reference: MSH:D004685
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:066.2
database_cross_reference: NCI:C35121
database_cross_reference: NDFRT:N0000001090
database_cross_reference: RCD:A662.
database_cross_reference: RCD:X000m
database_cross_reference: SNM:D-0391
database_cross_reference: SNMI:DE-33140
database_cross_reference: SNOMEDCT_US:417067005
database_cross_reference: SNOMEDCT_US:417702007
database_cross_reference: SNOMEDCT_US:89990001

urethral calculus
type: Class
subclass of: lower urinary tract calculus
PMOID: PMO:00032982
Subclass_of: lower urinary tract calculus
Synonym: CALCULUS URETHRAL
Synonym: Calculus in urethra
Synonym: Calculus in urethra (disorder)
Synonym: Calculus urethral
Synonym: URETHRA, CALCULUS
Synonym: URETHRAL CALCULUS
Synonym: Urethral Calculus
Synonym: Urethral Stone
Synonym: Urethral calculus
Synonym: Urethral calculus (disorder)
Tree Number: T10.8.7.7.2
database_cross_reference: CHV:0000017788
database_cross_reference: CST:BLADDER CALCULUS
database_cross_reference: DO:DOID:9589
database_cross_reference: DXP:U001958
database_cross_reference: DXP:U004220
database_cross_reference: ICD10:N21.1
database_cross_reference: ICD10AM:N21.1
database_cross_reference: ICD10CM:N21.1
database_cross_reference: ICD9CM:594.2
database_cross_reference: MDR:10006993
database_cross_reference: MDR:10007026
database_cross_reference: MDR:10046430
database_cross_reference: MEDCIN:30712
database_cross_reference: MEDCIN:319982
database_cross_reference: NCI:C26995
database_cross_reference: RCD:K141.
database_cross_reference: SNMI:D7-23370
database_cross_reference: SNOMEDCT_US:155880008
database_cross_reference: SNOMEDCT_US:20342001
database_cross_reference: SNOMEDCT_VET:20342001

lower urinary tract calculus
type: Class
subclass of: urinary system disease
definition: A urinary system disease that is located_in the lower urinary tract and is characterized by the formation of a stone.
PMOID: PMO:00032979
Subclass_of: urinary system disease
Synonym: Calculus of lower urinary tract
Synonym: Calculus of lower urinary tract (disorder)
Synonym: Calculus of lower urinary tract, NOS
Synonym: Calculus of lower urinary tract, unspecified
Synonym: Lower urin calcul NOS
Synonym: Lower urinary tract calcul.NOS
Synonym: Lower urinary tract calculus
Synonym: Lower urinary tract calculus (disorder)
Synonym: Lower urinary tract calculus NOS
Synonym: Lower urinary tract calculus NOS (disorder)
Tree Number: T10.8.7.7
database_cross_reference: DO:DOID:9590
database_cross_reference: ICD10:N21
database_cross_reference: ICD10:N21.9
database_cross_reference: ICD10AM:N21
database_cross_reference: ICD10AM:N21.9
database_cross_reference: ICD10CM:N21
database_cross_reference: ICD10CM:N21.9
database_cross_reference: ICD9CM:594
database_cross_reference: ICD9CM:594.9
database_cross_reference: MDR:10007015
database_cross_reference: MDR:10007016
database_cross_reference: MEDCIN:210514
database_cross_reference: RCD:K14..
database_cross_reference: RCD:K14z.
database_cross_reference: SNMI:D7-21800
database_cross_reference: SNOMEDCT_US:155878002
database_cross_reference: SNOMEDCT_US:155881007
database_cross_reference: SNOMEDCT_US:197828005
database_cross_reference: SNOMEDCT_US:197832004
database_cross_reference: SNOMEDCT_US:79509009

fasciitis
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032279
Subclass_of: connective tissue disease
Synonym: FASCIITIS
Synonym: FASCIITIS, DIFFUSE
Synonym: FASCITIS
Synonym: Fasciitides
Synonym: Fasciitis
Synonym: Fasciitis (disorder)
Synonym: Fasciitis NOS
Synonym: Fasciitis [Disease/Finding]
Synonym: Fasciitis unspecified
Synonym: Fasciitis unspecified (disorder)
Tree Number: T10.8.4.1.11
database_cross_reference: AOD:0000005147
database_cross_reference: CCPSS:0056895
database_cross_reference: CCPSS:1017839
database_cross_reference: CHV:0000004902
database_cross_reference: COSTAR:297
database_cross_reference: CST:FIBRO TENDON
database_cross_reference: DO:DOID:9598
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0100537
database_cross_reference: ICD10CM:M72.9
database_cross_reference: ICD9CM:729.4
database_cross_reference: ICPC2P:L87013
database_cross_reference: ICPC2P:L99074
database_cross_reference: MDR:10016228
database_cross_reference: MDR:10016230
database_cross_reference: MDR:10016231
database_cross_reference: MDR:10016238
database_cross_reference: MEDCIN:34470
database_cross_reference: MSH:D005208
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C50559
database_cross_reference: NCI_FDA:2375
database_cross_reference: NCI_NICHD:C50559
database_cross_reference: NDFRT:N0000001212
database_cross_reference: RCD:N244.
database_cross_reference: SNMI:D1-50730
database_cross_reference: SNOMEDCT_US:203123000
database_cross_reference: SNOMEDCT_US:36948007
database_cross_reference: SNOMEDCT_VET:36948007

staphyloenterotoxemia
type: Class
subclass of: primary bacterial infectious disease
definition: A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.
PMOID: PMO:00029532
Subclass_of: primary bacterial infectious disease
Synonym: FOOD POIS STAPH
Synonym: FOOD POISONING, STAPHYLOCOCCAL
Synonym: Food Poisoning, Staphylococcal
Synonym: Food Poisonings, Staphylococcal
Synonym: Food poisoning caused by staphylococcus
Synonym: Food poisoning caused by staphylococcus (disorder)
Synonym: Food poisoning due to staphylococcus
Synonym: Food poisoning due to staphylococcus (disorder)
Synonym: Food poisoning, staphylococcal
Synonym: Foodborne staphylococcal intoxication
Tree Number: T10.7.3.1.27
database_cross_reference: CHV:0000011691
database_cross_reference: DO:DOID:96
database_cross_reference: DXP:U000679
database_cross_reference: ICD10:A05.0
database_cross_reference: ICD10AM:A05.0
database_cross_reference: ICD10CM:A05.0
database_cross_reference: ICD9CM:005.0
database_cross_reference: MDR:10041921
database_cross_reference: MSH:D013202
database_cross_reference: MTHICD9:005.0
database_cross_reference: NCI:C35037
database_cross_reference: NDFRT:N0000002816
database_cross_reference: RCD:A040.
database_cross_reference: SNM:D-0127
database_cross_reference: SNMI:DE-11340
database_cross_reference: SNOMEDCT_US:84622004

orthostatic proteinuria
type: Class
subclass of: kidney disease
PMOID: PMO:00032986
Subclass_of: kidney disease
Synonym: Albuminuria, orthostatic
Synonym: Albuminuria, postural
Synonym: Albuminuria;orthostatic
Synonym: Albuminuria;postural
Synonym: Benign postural proteinuria
Synonym: Benign postural proteinuria (disorder)
Synonym: Orthostatic albuminuria
Synonym: Orthostatic albuminuria/proteinuria
Synonym: Orthostatic proteinuria
Synonym: Orthostatic proteinuria (disorder)
Tree Number: T10.8.7.9.1
database_cross_reference: CHV:0000023034
database_cross_reference: DO:DOID:9617
database_cross_reference: ICD10:N39.2
database_cross_reference: ICD10AM:N39.2
database_cross_reference: ICD10CM:R80.2
database_cross_reference: ICD9CM:593.6
database_cross_reference: ICPC2EENG:U90
database_cross_reference: ICPC2P:U90001
database_cross_reference: ICPC2P:U90002
database_cross_reference: ICPC2P:U90003
database_cross_reference: ICPC2P:U90007
database_cross_reference: MDR:10031124
database_cross_reference: MDR:10031129
database_cross_reference: MDR:10036435
database_cross_reference: MEDCIN:30672
database_cross_reference: MEDCIN:30679
database_cross_reference: MTHICD9:593.6
database_cross_reference: RCD:K136.
database_cross_reference: SNM:F-12720
database_cross_reference: SNMI:D7-11252
database_cross_reference: SNMI:F-73130
database_cross_reference: SNMI:F-73140
database_cross_reference: SNOMEDCT_US:155874000
database_cross_reference: SNOMEDCT_US:32482005
database_cross_reference: SNOMEDCT_US:77872002
database_cross_reference: SNOMEDCT_US:78719009

vesicoureteral reflux
type: Class
subclass of: ureteral disease
definition: A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter.
PMOID: PMO:00032973
Subclass_of: ureteral disease
Synonym: REFLUX, VESICOURETERAL
Synonym: Reflux, Vesico-Ureteral
Synonym: Reflux, Vesicoureteral
Synonym: Reflux;ureteric
Synonym: Ureteral reflux
Synonym: Ureteric reflux
Synonym: VESICOURETER REFLUX
Synonym: VESICOURETERAL REFLUX 1
Synonym: VUR
Synonym: VUR - Vesicoureteral Reflux
Tree Number: T10.8.7.5.2
database_cross_reference: CCPSS:0018532
database_cross_reference: CHV:0000012974
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:9620
database_cross_reference: DXP:U001655
database_cross_reference: HPO:HP:0000076
database_cross_reference: ICD10CM:N13.7
database_cross_reference: ICD10CM:N13.70
database_cross_reference: ICD9CM:593.7
database_cross_reference: ICPC2P:U99013
database_cross_reference: LCH:U004932
database_cross_reference: LCH_NW:sh85142929
database_cross_reference: MDR:10046408
database_cross_reference: MDR:10047370
database_cross_reference: MDR:10047371
database_cross_reference: MEDCIN:30707
database_cross_reference: MSH:D014718
database_cross_reference: NCI:C84467
database_cross_reference: NCI_NICHD:C84467
database_cross_reference: NDFRT:N0000003122
database_cross_reference: OMIM:193000
database_cross_reference: OMIM:MTHU003461
database_cross_reference: OMIM:MTHU004590
database_cross_reference: OMIM:MTHU017505
database_cross_reference: RCD:K137.
database_cross_reference: SNM:F-65830
database_cross_reference: SNMI:F-72030
database_cross_reference: SNOMEDCT_US:155875004
database_cross_reference: SNOMEDCT_US:197811007
database_cross_reference: SNOMEDCT_US:251994004
database_cross_reference: SNOMEDCT_US:26836002

kidney hypertrophy
type: Class
subclass of: kidney disease
PMOID: PMO:00033037
Subclass_of: kidney disease
Synonym: Hypertrophic;kidney
Synonym: Hypertrophy of kidney
Synonym: Hypertrophy of kidney (disorder)
Synonym: Hypertrophy of the Kidney
Synonym: Renal Hypertrophy
Synonym: Renal hypertrophy
Synonym: hypertrophic kidney
Synonym: hypertrophy of kidney
Synonym: hypertrophy of kidney (diagnosis)
Synonym: renal hypertrophy
Tree Number: T10.8.7.9.13
database_cross_reference: CHV:0000017560
database_cross_reference: CSP:1682-3011
database_cross_reference: DO:DOID:9622
database_cross_reference: ICD10CM:N28.81
database_cross_reference: ICD9CM:593.1
database_cross_reference: ICPC2P:U99020
database_cross_reference: MDR:10020888
database_cross_reference: MDR:10038468
database_cross_reference: MEDCIN:96701
database_cross_reference: NCI:C122991
database_cross_reference: NCI_NICHD:C122991
database_cross_reference: RCD:K131.
database_cross_reference: SNMI:D7-11620
database_cross_reference: SNOMEDCT_US:197800004
database_cross_reference: SNOMEDCT_US:88531004

stomatitis
type: Class
subclass of: mouth disease
PMOID: PMO:00033732
Subclass_of: mouth disease
Synonym: Inflammation of mouth
Synonym: Inflammation of oral mucosa
Synonym: Inflammation of the mouth
Synonym: Inflammatory condition of oral mucous membrane
Synonym: MUCOSITIS ORAL
Synonym: Mucositis oral
Synonym: Oral Mucositis
Synonym: Oral mucositis
Synonym: STOMATITIS
Synonym: Stomatitides
Tree Number: T10.8.11.11.9
database_cross_reference: AOD:0000005472
database_cross_reference: CCPSS:0004795
database_cross_reference: CHV:0000011746
database_cross_reference: COSTAR:703
database_cross_reference: CSP:2139-2403
database_cross_reference: CST:STOMATITIS
database_cross_reference: DO:DOID:9637
database_cross_reference: DXP:U003815
database_cross_reference: HPO:HP:0010280
database_cross_reference: ICD10CM:K12.1
database_cross_reference: LCH:U004481
database_cross_reference: LCH_NW:sh85128278
database_cross_reference: MDR:10028130
database_cross_reference: MDR:10042128
database_cross_reference: MEDCIN:30807
database_cross_reference: MSH:D013280
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26887
database_cross_reference: NCI_CTCAE:E10872
database_cross_reference: NCI_NCI-GLOSS:CDR0000044733
database_cross_reference: NCI_NICHD:C26887
database_cross_reference: NDFRT:N0000002832
database_cross_reference: OMIM:MTHU008854
database_cross_reference: RCD:J080.
database_cross_reference: RCD:J080z
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D5-21100
database_cross_reference: SNOMEDCT_US:155660009
database_cross_reference: SNOMEDCT_US:196527002
database_cross_reference: SNOMEDCT_US:61170000
database_cross_reference: SNOMEDCT_US:95361005
database_cross_reference: SNOMEDCT_VET:61170000

babesiosis
type: Class
subclass of: parasitic protozoa infectious disease
definition: A parasitic protozoa infectious disease that has_symptom mild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.
PMOID: PMO:00029685
Subclass_of: parasitic protozoa infectious disease
Synonym: Babesiasis
Synonym: Babesioses, Human
Synonym: Babesiosis, Human
Synonym: Human Babesioses
Synonym: Human Babesiosis
Synonym: Infection by babesia
Synonym: piroplasmosis
Tree Number: T10.7.4.2.5
database_cross_reference: DO:DOID:9643
database_cross_reference: MSH:D001404

oral mucosa leukoplakia
type: Class
subclass of: mouth disease
PMOID: PMO:00033641
Subclass_of: mouth disease
Synonym: Leukoplakia and other disturbances of oral epithelium, including tongue
Synonym: Leukoplakia of oral mucosa, incl tongue
Synonym: Leukoplakia of oral mucosa, including tongue
Synonym: Leukoplakia oral mucosa
Tree Number: T10.8.11.11.2
database_cross_reference: DO:DOID:9655
database_cross_reference: ICD10:K13.2
database_cross_reference: ICD10AM:K13.2
database_cross_reference: ICD10CM:K13.2
database_cross_reference: ICD10CM:K13.21
database_cross_reference: ICD9CM:528.6
database_cross_reference: MDR:10024393
database_cross_reference: MDR:10056766

yellow fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that results in infection, has material basis in Yellow fever virus, which is transmitted by Aedes, transmitted by Haemagogus, or transmitted by Sabethes species of mosquitoes. The infection has symptom fever, has symptom muscle pain, has symptom backache, has symptom headache, has symptom shivers, has symptom loss of appetite, has symptom jaundice, and has symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.
PMOID: PMO:00029351
Subclass_of: viral infectious disease
Synonym: Fever, Yellow
Synonym: Fevers, Yellow
Synonym: Sylvatic yellow fever
Synonym: Unspecified yellow fever
Synonym: YELLOW FEVER
Synonym: YF - Yellow fever
Synonym: Yellow Fever
Synonym: Yellow Fever Virus Infection
Synonym: Yellow Fever [Disease/Finding]
Synonym: Yellow Fevers
Tree Number: T10.7.2.5
database_cross_reference: CCPSS:0052454
database_cross_reference: CHV:0000013250
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:3100-3104
database_cross_reference: DO:DOID:9682
database_cross_reference: DXP:U002035
database_cross_reference: ICD10:A95
database_cross_reference: ICD10:A95.9
database_cross_reference: ICD10AM:A95
database_cross_reference: ICD10AM:A95.9
database_cross_reference: ICD10CM:A95
database_cross_reference: ICD10CM:A95.9
database_cross_reference: ICD9CM:060
database_cross_reference: ICD9CM:060.9
database_cross_reference: ICPC2P:A77007
database_cross_reference: LCH:U005071
database_cross_reference: LCH_NW:sh85149092
database_cross_reference: LNC:LA10520-7
database_cross_reference: MDR:10046248
database_cross_reference: MDR:10048240
database_cross_reference: MDR:10048242
database_cross_reference: MDR:10048243
database_cross_reference: MEDCIN:30853
database_cross_reference: MEDLINEPLUS:1652
database_cross_reference: MSH:D015004
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35547
database_cross_reference: NCI_NCI-GLOSS:CDR0000661209
database_cross_reference: NCI_NICHD:C35547
database_cross_reference: NDFRT:N0000003182
database_cross_reference: RCD:A60..
database_cross_reference: RCD:A60z.
database_cross_reference: RCD:Ayu94
database_cross_reference: RCDSY:Ayu94
database_cross_reference: SNM:D-0506
database_cross_reference: SNMI:DE-33210
database_cross_reference: SNOMEDCT_US:154345006
database_cross_reference: SNOMEDCT_US:16541001
database_cross_reference: SNOMEDCT_US:186587002
database_cross_reference: SNOMEDCT_US:187411002
database_cross_reference: SNOMEDCT_US:266194002

occlusion of gallbladder
type: Class
subclass of: gallbladder disease
PMOID: PMO:00033637
Subclass_of: gallbladder disease
Synonym: Gallbladder Obstruction
Synonym: Gallbladder obstruction
Synonym: Obstruction gallbladder
Synonym: Obstruction of gallbladder
Synonym: Obstruction of gallbladder (disorder)
Synonym: Obstruction of gallbladder NOS
Synonym: Obstruction of gallbladder NOS (disorder)
Synonym: Occlusion of gallbladder
Synonym: Occlusion of gallbladder (disorder)
Synonym: gallbladder obstruction
Tree Number: T10.8.11.10.6
database_cross_reference: DO:DOID:9714
database_cross_reference: ICD10:K82.0
database_cross_reference: ICD10AM:K82.0
database_cross_reference: ICD10CM:K82.0
database_cross_reference: ICD9CM:575.2
database_cross_reference: MDR:10017636
database_cross_reference: MDR:10029965
database_cross_reference: MEDCIN:34177
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78308
database_cross_reference: NCI_CTCAE:E11198
database_cross_reference: RCD:J652.
database_cross_reference: RCD:J6520
database_cross_reference: RCD:J652z
database_cross_reference: SNMI:D5-86000
database_cross_reference: SNOMEDCT_US:197415009
database_cross_reference: SNOMEDCT_US:197416005
database_cross_reference: SNOMEDCT_US:197420009
database_cross_reference: SNOMEDCT_US:75726005

hydrops of gallbladder
type: Class
subclass of: gallbladder disease
PMOID: PMO:00033636
Subclass_of: gallbladder disease
Synonym: Edematous gallbladder
Synonym: Edematous gallbladder (finding)
Synonym: GALLBLADDER, HYDROPS
Synonym: Gallbladder Hydrops
Synonym: Gallbladder edema
Synonym: Gallbladder oedema
Synonym: Hydrocholecystis
Synonym: Hydrops of gallbladder
Synonym: Hydrops of gallbladder (disorder)
Synonym: Hydrops, gallbladder
Tree Number: T10.8.11.10.5
database_cross_reference: CHV:0000017280
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:9717
database_cross_reference: DXP:U000692
database_cross_reference: ICD10:K82.1
database_cross_reference: ICD10AM:K82.1
database_cross_reference: ICD10CM:K82.1
database_cross_reference: ICD9CM:575.3
database_cross_reference: MDR:10017637
database_cross_reference: MDR:10020530
database_cross_reference: MDR:10054390
database_cross_reference: MDR:10056972
database_cross_reference: MEDCIN:30169
database_cross_reference: RCD:X308C
database_cross_reference: SNM:M-33300
database_cross_reference: SNMI:D5-86030
database_cross_reference: SNOMEDCT_US:197421008
database_cross_reference: SNOMEDCT_US:47312008
database_cross_reference: SNOMEDCT_VET:273701000009105

upper respiratory tract disease
type: Class
subclass of: respiratory system disease
definition: A respiratory system disease which involves the lower respiratory tract.
PMOID: PMO:00032456
Subclass_of: respiratory system disease
Synonym: Nasal & sinus dis NEC
Synonym: Other disease of nasal cavity and sinuses
Synonym: Other diseases of nasal cavity and sinuses
Synonym: Other nasal cavity and sinus disease
Synonym: Other nasal cavity and sinus disease (disorder)
Synonym: Other nasal cavity/sinus dis.
Synonym: lower respiratory tract disease
Tree Number: T10.8.5.2
database_cross_reference: DO:DOID:0050161
database_cross_reference: DO:DOID:974
database_cross_reference: ICD9CM:478.1
database_cross_reference: ICD9CM:478.19
database_cross_reference: MDR:10031910
database_cross_reference: RCD:XE0Y8
database_cross_reference: SNOMEDCT_US:195823002
database_cross_reference: SNOMEDCT_US:266346007

biliary tract disease
type: Class
subclass of: hepatobiliary disease
PMOID: PMO:00033484
Subclass_of: hepatobiliary disease
Synonym: BILIARY TRACT DIS
Synonym: BILIARY TRACT DISEASE, NOS
Synonym: Biliary Tract Disease
Synonym: Biliary Tract Diseases
Synonym: Biliary Tract Diseases [Disease/Finding]
Synonym: Biliary tract disease
Synonym: Biliary tract disorder
Synonym: Biliary tract disorder NOS
Synonym: Biliary tract disorders NOS
Synonym: Biliary tract disorders NOS (disorder)
Tree Number: T10.8.11.4.1
database_cross_reference: AOD:0000005677
database_cross_reference: BI:BI00213
database_cross_reference: CHV:0000001864
database_cross_reference: COSTAR:U000009
database_cross_reference: CSP:0413-3711
database_cross_reference: DO:DOID:9741
database_cross_reference: HPO:HP:0001080
database_cross_reference: ICD10:K83.9
database_cross_reference: ICD10AM:K83.9
database_cross_reference: ICD10CM:K83.9
database_cross_reference: ICD9CM:576.9
database_cross_reference: LCH_NW:sh85014022
database_cross_reference: MDR:10004676
database_cross_reference: MDR:10004677
database_cross_reference: MDR:10045772
database_cross_reference: MDR:10061008
database_cross_reference: MEDCIN:319160
database_cross_reference: MEDLINEPLUS:259
database_cross_reference: MEDLINEPLUS:3787
database_cross_reference: MSH:D001660
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000000551
database_cross_reference: RCD:X3081
database_cross_reference: RCD:XE0dR
database_cross_reference: SNM:D-6002
database_cross_reference: SNMI:D5-85050
database_cross_reference: SNOMEDCT_US:105997008
database_cross_reference: SNOMEDCT_US:155830002
database_cross_reference: SNOMEDCT_US:155832005
database_cross_reference: SNOMEDCT_US:266544009
database_cross_reference: SNOMEDCT_US:266545005
database_cross_reference: SNOMEDCT_US:5235004

heart aneurysm
type: Class
subclass of: heart disease
PMOID: PMO:00031769
Subclass_of: heart disease
Synonym: ANEURYSM, CARDIAC
Synonym: Aneurysm of heart
Synonym: Aneurysm of heart (disorder)
Synonym: Aneurysm of heart NOS
Synonym: Aneurysm of heart NOS (disorder)
Synonym: Aneurysm of heart, NOS
Synonym: Aneurysm, Cardiac
Synonym: Aneurysm, Heart
Synonym: Aneurysm;cardiac
Synonym: Aneurysms, Cardiac
Tree Number: T10.8.3.2.5
database_cross_reference: CCPSS:0033617
database_cross_reference: CHV:0000005866
database_cross_reference: CSP:1393-3252
database_cross_reference: DO:DOID:9768
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:I25.3
database_cross_reference: ICD10AM:I25.3
database_cross_reference: ICD10CM:I25.3
database_cross_reference: ICPC2P:K99032
database_cross_reference: MDR:10002350
database_cross_reference: MDR:10007513
database_cross_reference: MSH:D006322
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001428
database_cross_reference: RCD:G341.
database_cross_reference: RCD:G341z
database_cross_reference: SNMI:D3-10500
database_cross_reference: SNOMEDCT_US:155317009
database_cross_reference: SNOMEDCT_US:194847002
database_cross_reference: SNOMEDCT_US:65340007

irritable bowel syndrome
type: Class
subclass of: syndrome
definition: A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.
PMOID: PMO:00025163
Subclass_of: syndrome
Synonym: -- Irritable Bowel Syndrome
Synonym: Adaptive colitis
Synonym: Already mapped above AAHA ID #: 739
Synonym: BOWEL IRRITABLE
Synonym: BOWEL IRRITABLE SYNDROME
Synonym: COLITIS MUCOUS
Synonym: COLITIS, MUCOUS
Synonym: COLON SPASTIC
Synonym: COLON, SPASTIC
Synonym: Colitides, Mucous
Tree Number: T10.1.44
database_cross_reference: CCPSS:0042500
database_cross_reference: CCPSS:0051564
database_cross_reference: CHV:0000006932
database_cross_reference: COSTAR:429
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000563
database_cross_reference: CSP:1248-3974
database_cross_reference: CST:COLITIS
database_cross_reference: DO:DOID:9778
database_cross_reference: DXP:NOCODE
database_cross_reference: ICD10:K58
database_cross_reference: ICD10AM:K58
database_cross_reference: ICD10CM:K58
database_cross_reference: ICD10CM:K58.9
database_cross_reference: ICD9CM:564.1
database_cross_reference: ICPC2EENG:D93
database_cross_reference: ICPC2P:D93003
database_cross_reference: ICPC2P:D93007
database_cross_reference: ICPC2P:D93011
database_cross_reference: LCH_NW:sh85068314
database_cross_reference: LNC:LA10555-3
database_cross_reference: MDR:10009897
database_cross_reference: MDR:10009980
database_cross_reference: MDR:10017494
database_cross_reference: MDR:10021192
database_cross_reference: MDR:10023002
database_cross_reference: MDR:10023003
database_cross_reference: MDR:10023004
database_cross_reference: MDR:10023005
database_cross_reference: MDR:10028131
database_cross_reference: MDR:10041409
database_cross_reference: MEDCIN:30280
database_cross_reference: MEDLINEPLUS:614
database_cross_reference: MSH:D043183
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:564.1
database_cross_reference: NCI:C82343
database_cross_reference: NCI_NCI-GLOSS:CDR0000630908
database_cross_reference: NCI_NCI-GLOSS:CDR0000630909
database_cross_reference: NCI_NCI-GLOSS:CDR0000630910
database_cross_reference: NCI_NCI-GLOSS:CDR0000630911
database_cross_reference: NCI_NCI-GLOSS:CDR0000630912
database_cross_reference: NCI_NICHD:C82343
database_cross_reference: NDFRT:N0000010242
database_cross_reference: OMIM:MTHU038673
database_cross_reference: PSY:26659
database_cross_reference: RCD:XE0as
database_cross_reference: SNM:D-6253
database_cross_reference: SNM:F-62190
database_cross_reference: SNM:M-40480
database_cross_reference: SNMI:D5-44100
database_cross_reference: SNOMEDCT_US:10743008
database_cross_reference: SNOMEDCT_US:155783000
database_cross_reference: SNOMEDCT_US:192434000
database_cross_reference: SNOMEDCT_US:197124009
database_cross_reference: SNOMEDCT_US:266525002
database_cross_reference: SNOMEDCT_VET:10743008

bowel dysfunction
type: Class
subclass of: intestinal disease
definition: A gastrointestinal system disease that is located_in the intestine.
PMOID: PMO:00033594
Subclass_of: intestinal disease
Synonym: 5-40-45 DISEASES OF THE INTESTINAL TRACT
Synonym: Abnormality of the intestine
Synonym: BOWEL DISEASE
Synonym: Bowel Disorders
Synonym: DISEASES OF THE INTESTINAL TRACT
Synonym: DISEASES OF THE SMALL AND LARGE INTESTINES
Synonym: Disease of intestine
Synonym: Disease of intestine (disorder)
Synonym: Disease of intestine, NOS
Synonym: Disease of intestine, unspecified
Tree Number: T10.8.11.8.15
database_cross_reference: AOD:0000005614
database_cross_reference: AOD:0000023382
database_cross_reference: CCPSS:0011558
database_cross_reference: CHV:0000006853
database_cross_reference: CHV:0000030650
database_cross_reference: CSP:1248-5896
database_cross_reference: DO:DOID:5295
database_cross_reference: HPO:HP:0002242
database_cross_reference: ICD10:K63.9
database_cross_reference: ICD10AM:K63.9
database_cross_reference: ICD10CM:K63.9
database_cross_reference: ICD9CM:569.9
database_cross_reference: ICPC2P:D99052
database_cross_reference: LCH_NW:sh85067586
database_cross_reference: MDR:10045793
database_cross_reference: MEDCIN:335851
database_cross_reference: MEDLINEPLUS:194
database_cross_reference: MEDLINEPLUS:5446
database_cross_reference: MSH:D007410
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26801
database_cross_reference: NDFRT:N0000001698
database_cross_reference: OMIM:MTHU003979
database_cross_reference: PSY:06680
database_cross_reference: RCD:J5z..
database_cross_reference: RCD:X302f
database_cross_reference: SNMI:D5-40000
database_cross_reference: SNOMEDCT_US:155629009
database_cross_reference: SNOMEDCT_US:197266001
database_cross_reference: SNOMEDCT_US:266483008
database_cross_reference: SNOMEDCT_US:85919009

trichinosis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi. Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur.
PMOID: PMO:00029624
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Other and unspec helminthiases
Synonym: Other and unspecified helminthiases
Synonym: Other and unspecified helminthiases (disorder)
Synonym: Other helminthiases
Synonym: Other helminthiases (disorder)
Synonym: Trichinella spiralis infection
Tree Number: T10.7.4.1.7
database_cross_reference: DO:DOID:9784
database_cross_reference: ICD10:B83
database_cross_reference: ICD10AM:B83
database_cross_reference: ICD10CM:B83
database_cross_reference: ICD9CM:128
database_cross_reference: MDR:10031571
database_cross_reference: RCD:AC8..
database_cross_reference: RCD:Xa3eD
database_cross_reference: SNOMEDCT_US:154415009
database_cross_reference: SNOMEDCT_US:187183003
database_cross_reference: SNOMEDCT_US:266222003
database_cross_reference: SNOMEDCT_US:286885002

toxocariasis
type: Class
subclass of: parasitic helminthiasis infectious disease
definition: A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of Toxocara canis or Toxocara cati. The larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions.
PMOID: PMO:00029619
Subclass_of: parasitic helminthiasis infectious disease
Synonym: Infection by Toxascaris
Synonym: Toxocara infection
Synonym: visceral larva migrans
Tree Number: T10.7.4.1.2
database_cross_reference: DO:DOID:9790

radioulnar synostosis
type: Class
subclass of: physical disorder
PMOID: PMO:00028256
Subclass_of: physical disorder
Synonym: Fused forearm bones
Synonym: RADIOULNAR SYNOSTOSIS
Synonym: Radioulnar Synostosis
Synonym: Radioulnar synostosis
Synonym: Radioulnar synostosis (disorder)
Synonym: radioulnar synostosis (diagnosis)
Synonym: synostosis radioulnar
Tree Number: T10.4.2
database_cross_reference: CHV:0000017669
database_cross_reference: DO:DOID:9827
database_cross_reference: HPO:HP:0002974
database_cross_reference: ICD10CM:Q74.0
database_cross_reference: ICD9CM:755.53
database_cross_reference: MDR:10037798
database_cross_reference: MEDCIN:211308
database_cross_reference: MSH:C562408
database_cross_reference: OMIM:179300
database_cross_reference: OMIM:MTHU010006
database_cross_reference: PDQ:CDR0000285988
database_cross_reference: RCD:PF53.
database_cross_reference: SNMI:D4-13040
database_cross_reference: SNOMEDCT_US:33313004

neonatal abstinence syndrome
type: Class
subclass of: withdrawal disorder
definition: A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment.
PMOID: PMO:00027911
Subclass_of: withdrawal disorder
Synonym: Abstinence Syndrome, Neonatal
Synonym: Abstinence Syndromes, Neonatal
Synonym: Drug withdrawal syndrome in newborn
Synonym: Drug withdrawal syndrome in newborn (disorder)
Synonym: Drug withdrawal syndrome neonatal
Synonym: NAS
Synonym: NB drug withdrawal syndr
Synonym: Neonatal Abstinence Syndrome
Synonym: Neonatal Abstinence Syndrome (disorder)
Synonym: Neonatal Abstinence Syndrome [Disease/Finding]
Tree Number: T10.3.3.1.1
database_cross_reference: AOD:0000004932
database_cross_reference: AOD:0000023206
database_cross_reference: CHV:0000008557
database_cross_reference: CST:WITHDRAW SYND
database_cross_reference: DO:DOID:9828
database_cross_reference: ICD10CM:P96.1
database_cross_reference: ICD9CM:779.5
database_cross_reference: MDR:10013755
database_cross_reference: MDR:10013756
database_cross_reference: MDR:10048012
database_cross_reference: MDR:10074192
database_cross_reference: MEDCIN:35723
database_cross_reference: MSH:D009357
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87101
database_cross_reference: NCI_NICHD:C87101
database_cross_reference: NDFRT:N0000002120
database_cross_reference: RCD:Q485.
database_cross_reference: SNMI:D8-78330
database_cross_reference: SNOMEDCT_US:414819007
database_cross_reference: SNOMEDCT_US:61628006

interstitial keratitis
type: Class
subclass of: connective tissue disease
PMOID: PMO:00030811
Subclass_of: connective tissue disease
Synonym: IK - Interstitial keratitis
Synonym: Interstit keratitis NOS
Synonym: Interstitial keratitis
Synonym: Interstitial keratitis (disorder)
Synonym: Interstitial keratitis unspec.
Synonym: Interstitial keratitis, NOS
Synonym: Interstitial keratitis, unspecified
Synonym: KERATITIS INTERSTITIAL
Synonym: Keratitis interstitial
Synonym: Unspecified interstitial keratitis
Tree Number: T10.8.4.1.6
database_cross_reference: BI:BI00819
database_cross_reference: CCPSS:0048149
database_cross_reference: CHV:0000017450
database_cross_reference: DO:DOID:9857
database_cross_reference: ICD10CM:H16.30
database_cross_reference: ICD9CM:370.50
database_cross_reference: MDR:10022609
database_cross_reference: MDR:10022610
database_cross_reference: MDR:10023335
database_cross_reference: MEDCIN:30739
database_cross_reference: MEDCIN:6479
database_cross_reference: RCD:F4A50
database_cross_reference: RCD:X00am
database_cross_reference: SNMI:DA-75270
database_cross_reference: SNOMEDCT_US:1763009
database_cross_reference: SNOMEDCT_US:193784002

intestinal disaccharidase deficiency
type: Class
subclass of: carbohydrate metabolic disorder
subclass of: intestinal disease
PMOID: PMO:00029122
Subclass_of: carbohydrate metabolic disorder
Subclass_of: intestinal disease
Synonym: Disaccharidase def/malab
Synonym: Intestinal Disaccharidase Deficiency and Disaccharide Malabsorption
Synonym: Intestinal disaccharidase deficiencies and disaccharide malabsorption
Tree Number: T10.6.2.11.3
Tree Number: T10.8.11.8.5
database_cross_reference: DO:DOID:9868
database_cross_reference: ICD9CM:271.3
database_cross_reference: MDR:10022644
database_cross_reference: NCI:C34731

hereditary fructose intolerance syndrome
type: Class
subclass of: carbohydrate metabolic disorder
PMOID: PMO:00029119
Subclass_of: carbohydrate metabolic disorder
Synonym: ALDB - aldolase B deficiency
Synonym: ALDB - aldolose B deficiency
Synonym: ALDB deficiency
Synonym: ALDOB DEFICIENCY
Synonym: ALDOB Deficiencies
Synonym: ALDOB Deficiency
Synonym: ALDOLASE B DEFICIENCY
Synonym: Aldolase B Deficiencies
Synonym: Aldolase B Deficiency
Synonym: Aldolase B deficiency
Tree Number: T10.6.2.11.1
database_cross_reference: CHV:0000005275
database_cross_reference: CSP:1849-3494
database_cross_reference: DO:DOID:9869
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000687
database_cross_reference: DXP:U001625
database_cross_reference: HPO:HP:0005973
database_cross_reference: ICD10CM:E74.12
database_cross_reference: ICD9CM:271.2
database_cross_reference: MDR:10017397
database_cross_reference: MDR:10019878
database_cross_reference: MDR:10072104
database_cross_reference: MEDCIN:33545
database_cross_reference: MSH:D005633
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:271.2
database_cross_reference: NCI:C84720
database_cross_reference: NCI_NICHD:C84720
database_cross_reference: NDFRT:N0000001294
database_cross_reference: OMIM:229600
database_cross_reference: OMIM:612724
database_cross_reference: OMIM:MTHU026132
database_cross_reference: OMIM:MTHU026133
database_cross_reference: RCD:C312.
database_cross_reference: RCDAE:C312.
database_cross_reference: SNM:D-1285
database_cross_reference: SNMI:D6-50601
database_cross_reference: SNMI:D6-50620
database_cross_reference: SNOMEDCT_US:20052008
database_cross_reference: SNOMEDCT_US:20290005
database_cross_reference: SNOMEDCT_US:237962008

galactosemia
type: Class
subclass of: carbohydrate metabolic disorder
definition: A carbohydrate metabolic disorder that involves a defect in galactose metabolism resulting in toxic levels of galactose 1-phosphate in various tissues.
PMOID: PMO:00029130
Subclass_of: carbohydrate metabolic disorder
Synonym: GALACTOSE INTOLERANCE
Synonym: GALACTOSEMIA
Synonym: Galactosaemia
Synonym: Galactosaemia NOS
Synonym: Galactosaemia, NOS
Synonym: Galactose intolerance
Synonym: Galactose intolerance, NOS
Synonym: Galactosemia
Synonym: Galactosemia (disorder)
Synonym: Galactosemia (disorder) [Ambiguous]
Tree Number: T10.6.2.11.9
database_cross_reference: AOD:0000005717
database_cross_reference: CHV:0000005317
database_cross_reference: CSP:1849-3608
database_cross_reference: DO:DOID:9870
database_cross_reference: DXP:U000689
database_cross_reference: DXP:U001633
database_cross_reference: HPO:HP:0004919
database_cross_reference: HPO:HP:0012024
database_cross_reference: ICD10CM:E74.21
database_cross_reference: ICD9CM:271.1
database_cross_reference: LCH:U001900
database_cross_reference: LCH_NW:sh85052749
database_cross_reference: LNC:LP56739-3
database_cross_reference: LNC:MTHU021572
database_cross_reference: MDR:10017604
database_cross_reference: MDR:10017605
database_cross_reference: MDR:10017610
database_cross_reference: MEDCIN:33546
database_cross_reference: MSH:D005693
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84723
database_cross_reference: NCI_NICHD:C84723
database_cross_reference: NDFRT:N0000001303
database_cross_reference: OMIM:MTHU012915
database_cross_reference: RCD:C311.
database_cross_reference: RCD:C311z
database_cross_reference: RCDAE:C311.
database_cross_reference: RCDAE:C311z
database_cross_reference: SNM:D-1270
database_cross_reference: SNMI:D6-50500
database_cross_reference: SNOMEDCT_US:154738008
database_cross_reference: SNOMEDCT_US:190745006
database_cross_reference: SNOMEDCT_US:190747003
database_cross_reference: SNOMEDCT_US:190749000
database_cross_reference: SNOMEDCT_US:267498002
database_cross_reference: SNOMEDCT_US:38177000

urethral gland abscess
type: Class
subclass of: urethral disease
PMOID: PMO:00032969
Subclass_of: urethral disease
Synonym: Abscess (of) urethral (gland)
Synonym: URETHRA ABSCESS
Synonym: Urethral abscess
Synonym: Urethral abscess (disorder)
Synonym: Urethral abscess NOS
Synonym: Urethral abscess NOS (disorder)
Synonym: Urethral abscess unspecified
Synonym: Urethral abscess unspecified (disorder)
Synonym: Urethral abscess, NOS
Synonym: Urethral gland abscess
Tree Number: T10.8.7.3.9
database_cross_reference: CCPSS:0012080
database_cross_reference: CHV:0000017565
database_cross_reference: DO:DOID:9877
database_cross_reference: ICD10:N34.0
database_cross_reference: ICD10AM:N34.0
database_cross_reference: ICD10CM:N34.0
database_cross_reference: ICD9CM:597.0
database_cross_reference: MDR:10046424
database_cross_reference: MEDCIN:34833
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:597.0
database_cross_reference: RCD:K1700
database_cross_reference: RCD:K170z
database_cross_reference: RCD:X30P6
database_cross_reference: SNMI:D7-23200
database_cross_reference: SNOMEDCT_US:197899005
database_cross_reference: SNOMEDCT_US:197900000
database_cross_reference: SNOMEDCT_US:197901001
database_cross_reference: SNOMEDCT_US:197902008
database_cross_reference: SNOMEDCT_US:67277002

hydrocele
type: Class
subclass of: male reproductive system disease
PMOID: PMO:00029765
Subclass_of: male reproductive system disease
Synonym: HYDROCELE
Synonym: Hydrocele
Synonym: Hydrocele (disorder)
Synonym: Hydrocele (morphologic abnormality)
Synonym: Hydrocele NOS
Synonym: Hydrocele NOS (disorder)
Synonym: Hydrocele of testis
Synonym: Hydrocele of testis (disorder)
Synonym: Hydrocele sac
Synonym: Hydrocele testis
Tree Number: T10.8.1.3.7
database_cross_reference: CCPSS:0036183
database_cross_reference: CCPSS:0038697
database_cross_reference: CHV:0000026376
database_cross_reference: COSTAR:U000360
database_cross_reference: DO:DOID:9912
database_cross_reference: DXP:U002005
database_cross_reference: HPO:HP:0000034
database_cross_reference: HPO:HP:0100673
database_cross_reference: ICD10:N43.3
database_cross_reference: ICD10AM:N43.3
database_cross_reference: ICD10CM:N43.3
database_cross_reference: ICD9CM:603
database_cross_reference: ICD9CM:603.9
database_cross_reference: ICPC2EENG:Y86
database_cross_reference: ICPC2P:Y86001
database_cross_reference: LCH:U002271
database_cross_reference: LCH_NW:sh85063377
database_cross_reference: MDR:10020488
database_cross_reference: MDR:10020502
database_cross_reference: MEDCIN:30716
database_cross_reference: MEDCIN:7513
database_cross_reference: MEDCIN:96729
database_cross_reference: MSH:D006848
database_cross_reference: NDFRT:N0000001565
database_cross_reference: OMIM:MTHU036912
database_cross_reference: RCD:K23..
database_cross_reference: RCD:K23z.
database_cross_reference: SNM:M-33380
database_cross_reference: SNMI:D7-54100
database_cross_reference: SNMI:D7-54114
database_cross_reference: SNOMEDCT_US:155912008
database_cross_reference: SNOMEDCT_US:197982005
database_cross_reference: SNOMEDCT_US:26614003
database_cross_reference: SNOMEDCT_US:386152007
database_cross_reference: SNOMEDCT_US:55434001

Omsk hemorrhagic fever
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.
PMOID: PMO:00029347
Subclass_of: viral infectious disease
Synonym: Fever, Omsk Hemorrhagic
Synonym: Hemorrhagic Fever, Omsk
Synonym: Hemorrhagic Fever, Omsk [Disease/Finding]
Synonym: Hemorrhagic fever, Omsk
Synonym: OHF - Omsk haemorrhagic fever
Synonym: OHF - Omsk hemorrhagic fever
Synonym: Omsk Hemorrhagic Fever
Synonym: Omsk haemorrhagic fever
Synonym: Omsk hemorrhagic fever (diagnosis)
Synonym: Omsk hemorrhagic fever (disorder)
Tree Number: T10.7.2.1
database_cross_reference: CHV:0000006018
database_cross_reference: DO:DOID:992
database_cross_reference: ICD10:A98.1
database_cross_reference: ICD10AM:A98.1
database_cross_reference: ICD10AMAE:A98.1
database_cross_reference: ICD10CM:A98.1
database_cross_reference: ICD9CM:065.1
database_cross_reference: LCH:U002159
database_cross_reference: LCH_NW:sh85060232
database_cross_reference: MDR:10030310
database_cross_reference: MDR:10030311
database_cross_reference: MEDCIN:30852
database_cross_reference: MSH:D006481
database_cross_reference: NDFRT:N0000001490
database_cross_reference: RCD:A651.
database_cross_reference: RCDAE:A651.
database_cross_reference: SNM:D-0440
database_cross_reference: SNMI:DE-33360
database_cross_reference: SNOMEDCT_US:48113006

developmental coordination disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired.
PMOID: PMO:00028001
Subclass_of: specific developmental disorder
Synonym: Clumsy Child Syndrome
Synonym: Coordination Disorder, Developmental
Synonym: DEVELOPMENTAL COORDINATION DIS
Synonym: Devel coordination dis
Synonym: Development Coordination Disorder
Synonym: Developmental Coordination Disorder
Synonym: Developmental Coordination Disorders
Synonym: Developmental Dyspraxia
Synonym: Developmental coordination disorder
Synonym: Developmental coordination disorder (disorder)
Tree Number: T10.3.5.1.7
database_cross_reference: AOD:0000006241
database_cross_reference: DO:DOID:9923
database_cross_reference: DSM-5:315.4
database_cross_reference: DSM-5:F82
database_cross_reference: ICD10CM:F82
database_cross_reference: ICD9CM:315.4
database_cross_reference: MDR:10012557
database_cross_reference: MDR:10012558
database_cross_reference: MEDCIN:35790
database_cross_reference: MSH:D019957
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92561
database_cross_reference: NCI_NICHD:C92561
database_cross_reference: SNMI:D9-18231
database_cross_reference: SNOMEDCT_US:192578006
database_cross_reference: SNOMEDCT_US:27544004

Waterhouse-Friderichsen syndrome
type: Class
subclass of: adrenal gland disease
definition: An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.
PMOID: PMO:00033240
Subclass_of: adrenal gland disease
Synonym: Meningococcal hemorrhagic adrenalitis
Synonym: Purpura Fulminans (Waterhouse-Friderichsen Syndrome)
Synonym: WFS
Synonym: Waterhouse Friderichsen Syndrome
Synonym: Waterhouse Friederichsen Syndrome
Synonym: Waterhouse-Friderichen
Synonym: Waterhouse-Friderichsen Syndrome
Synonym: Waterhouse-Friderichsen Syndrome [Disease/Finding]
Synonym: Waterhouse-Friederichsen Syndrome
Synonym: adrenal hemorrhage syndrome
Tree Number: T10.8.8.6.3
database_cross_reference: CHV:0000013122
database_cross_reference: DO:DOID:9931
database_cross_reference: MSH:D014884
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85225
database_cross_reference: NDFRT:N0000003155
database_cross_reference: SNOMEDCT_US:154709005
database_cross_reference: SNOMEDCT_US:267484005

lymph node disease
type: Class
subclass of: lymphatic system disease
PMOID: PMO:00032944
Subclass_of: lymphatic system disease
Synonym: C-72 DISEASES OF THE LYMPH NODES
Synonym: DISEASES OF THE LYMPH NODES
Synonym: Disease of lymph node
Synonym: Disease of lymph node (disorder)
Synonym: Disease of lymph node, NOS
Synonym: Disorder of lymph node
Synonym: Disorder of lymph node (disorder)
Synonym: Lymph Node Disorder
Synonym: Lymph node disorder
Synonym: Lymph nodes--Diseases
Tree Number: T10.8.6.4.9
database_cross_reference: CHV:0000026722
database_cross_reference: CST:HAL/LYM/GLN
database_cross_reference: DO:DOID:9942
database_cross_reference: LCH_NW:sh87004915
database_cross_reference: MDR:10049158
database_cross_reference: NCI:C35346
database_cross_reference: RCD:X206a
database_cross_reference: SNMI:DC-72000
database_cross_reference: SNOMEDCT_US:76616003

periostitis
type: Class
subclass of: connective tissue disease
PMOID: PMO:00032301
Subclass_of: connective tissue disease
Synonym: PERIOSTEITIS
Synonym: PERIOSTITIS
Synonym: Periostalgia
Synonym: Periosteitis
Synonym: Periosteitis fibrosa
Synonym: Periostitides
Synonym: Periostitis
Synonym: Periostitis (disorder)
Synonym: Periostitis [Disease/Finding]
Synonym: Periostitis, NOS
Tree Number: T10.8.4.1.17
database_cross_reference: AOD:0000005152
database_cross_reference: CHV:0000009514
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:PERIOST DIS
database_cross_reference: DO:DOID:9957
database_cross_reference: DXP:U001464
database_cross_reference: DXP:U003095
database_cross_reference: HPO:HP:0040165
database_cross_reference: ICPC2P:L70016
database_cross_reference: MDR:10034550
database_cross_reference: MDR:10034551
database_cross_reference: MEDCIN:31289
database_cross_reference: MSH:D010522
database_cross_reference: NDFRT:N0000002374
database_cross_reference: RCD:X70Ao
database_cross_reference: SNM:M-40000
database_cross_reference: SNM:M-74820
database_cross_reference: SNMI:D1-60260
database_cross_reference: SNOMEDCT_US:41910004

carotenemia
type: Class
subclass of: acquired metabolic disease
PMOID: PMO:00028948
Subclass_of: acquired metabolic disease
Synonym: Aurantiasis
Synonym: CAROTENEMIA
Synonym: Carotenaemia
Synonym: Carotenemia
Synonym: Hypercarotenaemia
Synonym: Hypercarotinaemia
Synonym: Hypercarotinemia
Synonym: Hypercarotinemia (disorder)
Synonym: aurantiasis
Synonym: carotenemia (diagnosis)
Tree Number: T10.6.1.8
database_cross_reference: CHV:0000017390
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:9969
database_cross_reference: DXP:U000297
database_cross_reference: ICD10:E67.1
database_cross_reference: ICD10AM:E67.1
database_cross_reference: ICD10CM:E67.1
database_cross_reference: ICD9CM:278.3
database_cross_reference: MDR:10007673
database_cross_reference: MDR:10007679
database_cross_reference: MDR:10020594
database_cross_reference: MDR:10020595
database_cross_reference: MEDCIN:33621
database_cross_reference: NCI:C26963
database_cross_reference: RCD:C383.
database_cross_reference: RCDAE:C383.
database_cross_reference: SNM:M-57000
database_cross_reference: SNMI:D6-C0310
database_cross_reference: SNOMEDCT_US:35487009

substance dependence
type: Class
subclass of: substance-related disorder
PMOID: PMO:00027922
Subclass_of: substance-related disorder
Synonym: Addiction, Substance
Synonym: Dependence, Substance
Synonym: SUBSTANCE DEPENDENCE
Synonym: Substance Addiction
Synonym: Substance Dependence
Synonym: Substance dependence
Synonym: Substance dependence, NOS
Synonym: addiction chemical
Synonym: addictions substance
Synonym: chemical addiction
Tree Number: T10.3.3.3
database_cross_reference: CCPSS:0004383
database_cross_reference: CHV:0000011821
database_cross_reference: CHV:0000043769
database_cross_reference: MDR:10076595
database_cross_reference: MEDCIN:338637
database_cross_reference: MSH:D019966
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:D9-30020
database_cross_reference: SNOMEDCT_US:2403008

drug dependence
type: Class
subclass of: substance dependence
PMOID: PMO:00027923
Subclass_of: substance dependence
Synonym: Abuse;drug(s);dependent
Synonym: Addiction any drug
Synonym: Addiction to drugs
Synonym: Addiction, Drug
Synonym: Addiction;drug(s)
Synonym: Chemical Dependence
Synonym: DEPENDENCE DRUG (NOS)
Synonym: DRUG ADDICTION
Synonym: DRUG DEPENDENCE
Synonym: Dependence drug (NOS)
Tree Number: T10.3.3.3.1
database_cross_reference: AOD:0000022835
database_cross_reference: AOD:0000022836
database_cross_reference: AOD:0000022837
database_cross_reference: CCPSS:0055240
database_cross_reference: CCPSS:0058260
database_cross_reference: CHV:0000011821
database_cross_reference: COSTAR:251
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0962-7753
database_cross_reference: CST:DRUG DEPEND
database_cross_reference: CST:DRUG DEPEND ADDICT
database_cross_reference: ICD9CM:304
database_cross_reference: ICD9CM:304.9
database_cross_reference: ICPC2P:P19001
database_cross_reference: ICPC2P:P19002
database_cross_reference: ICPC2P:P19005
database_cross_reference: LNC:LA6189-0
database_cross_reference: MDR:10001126
database_cross_reference: MDR:10001127
database_cross_reference: MDR:10012337
database_cross_reference: MDR:10013658
database_cross_reference: MDR:10013663
database_cross_reference: MDR:10013666
database_cross_reference: MDR:10013677
database_cross_reference: MDR:10045850
database_cross_reference: MEDCIN:276385
database_cross_reference: MEDCIN:350281
database_cross_reference: MSH:D019966
database_cross_reference: MTH:250
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:304.9
database_cross_reference: NCI:C3894
database_cross_reference: PSY:13610
database_cross_reference: PSY:15230
database_cross_reference: PSY:15270
database_cross_reference: RCD:E24..
database_cross_reference: RCD:E24z.
database_cross_reference: RCD:Xa9B1
database_cross_reference: SNM:D-9270
database_cross_reference: SNM:F-Y0290
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D9-30020
database_cross_reference: SNMI:DF-10202
database_cross_reference: SNOMEDCT_US:154909004
database_cross_reference: SNOMEDCT_US:154915004
database_cross_reference: SNOMEDCT_US:191816009
database_cross_reference: SNOMEDCT_US:191878004
database_cross_reference: SNOMEDCT_US:192310006
database_cross_reference: SNOMEDCT_US:2403008
database_cross_reference: SNOMEDCT_US:6525002

hypereosinophilic syndrome
type: Class
subclass of: leukocyte disease
PMOID: PMO:00033394
Subclass_of: leukocyte disease
Synonym: C-45 EOSINOPHILIAS
Synonym: EOSINOPHILIA
Synonym: EOSINOPHILIAS
Synonym: EOSINOPHILS INCREASED
Synonym: Eosinophilia
Synonym: Eosinophilia (disorder)
Synonym: Eosinophilia (disorder) [Ambiguous]
Synonym: Eosinophilia NOS
Synonym: Eosinophilia NOS (disorder)
Synonym: Eosinophilia [Disease/Finding]
Tree Number: T10.8.10.6.1
database_cross_reference: CCPSS:1004431
database_cross_reference: CHV:0000004529
database_cross_reference: COSTAR:U000240
database_cross_reference: CSP:0427-6368
database_cross_reference: CST:EOSINOPHILIA
database_cross_reference: DO:DOID:999
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001129
database_cross_reference: HPO:HP:0001880
database_cross_reference: ICD10:D72.1
database_cross_reference: ICD10AM:D72.1
database_cross_reference: ICD10CM:D72.1
database_cross_reference: ICD9CM:288.3
database_cross_reference: ICPC2P:B84006
database_cross_reference: LCH:U001620
database_cross_reference: LCH_NW:sh85044243
database_cross_reference: MDR:10014950
database_cross_reference: MEDCIN:273754
database_cross_reference: MEDCIN:34857
database_cross_reference: MSH:D004802
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:288.3
database_cross_reference: NDFRT:N0000001115
database_cross_reference: OMIM:MTHU004968
database_cross_reference: RCD:D403.
database_cross_reference: RCD:D403z
database_cross_reference: SNM:M-77600
database_cross_reference: SNMI:DC-45000
database_cross_reference: SNMI:DC-45010
database_cross_reference: SNOMEDCT_US:165524009
database_cross_reference: SNOMEDCT_US:191363000
database_cross_reference: SNOMEDCT_US:27955006
database_cross_reference: SNOMEDCT_US:418928000

Abnormality of body height
type: Class
subclass of: Growth abnormality
definition: Deviation from the norm of height with respect to that which is expected according to age and gender norms.
PMOID: PMO:00014116
Subclass_of: Growth abnormality
Tree Number: T3.24.1
database_cross_reference: HPO:HP:0000002

Abnormality of the genital system
type: Class
subclass of: Abnormality of the genitourinary system
definition: An abnormality of the genital system.
PMOID: PMO:00007484
Subclass_of: Abnormality of the genitourinary system
Synonym: Genital abnormalities
Synonym: Genital abnormality
Synonym: Genital anomalies
Synonym: Genital defects
Tree Number: T3.14.1
database_cross_reference: HPO:HP:0000078

Abnormality of the urinary system
type: Class
subclass of: Abnormality of the genitourinary system
definition: An abnormality of the urinary system.
PMOID: PMO:00007795
Subclass_of: Abnormality of the genitourinary system
Synonym: Urinary tract abnormalities
Synonym: Urinary tract abnormality
Synonym: Urinary tract anomalies
Tree Number: T3.14.2
database_cross_reference: HPO:HP:0000079

Abnormality of reproductive system physiology
type: Class
subclass of: Abnormality of the genital system
definition: An abnormal functionality of the genital system.
PMOID: PMO:00007751
Subclass_of: Abnormality of the genital system
Synonym: Genital functional abnormality
Tree Number: T3.14.1.2
database_cross_reference: HPO:HP:0000080

Tall stature
type: Class
subclass of: Abnormality of body height
definition: A height above that which is expected according to age and gender norms.
PMOID: PMO:00014140
Subclass_of: Abnormality of body height
Synonym: Accelerated linear growth
Synonym: Increased body height
Synonym: Increased linear growth
Tree Number: T3.24.1.3
database_cross_reference: HPO:HP:0000098

Phenotypic Abnormality
type: Class
subclass of: Thing
definition: A phenotypic abnormality.
PMOID: PMO:00000866
Subclass_of: owl:Thing
Synonym: Organ abnormality
Synonym: Phenotypic abnormality
Tree Number: T3
database_cross_reference: HPO:HP:0000118

Abnormality of the genitourinary system
type: Class
subclass of: Phenotypic Abnormality
definition: The presence of any abnormality of the genitourinary system.
PMOID: PMO:00007483
Subclass_of: Phenotypic Abnormality
Synonym: ABNORM UROGENITAL
Synonym: ANOMALY CONGENITAL UROGENITAL
Synonym: Abnormalities, Genitourinary
Synonym: Abnormalities, Urogenital
Synonym: Abnormality, Genitourinary
Synonym: Abnormality, Urogenital
Synonym: Anomaly congenital urogenital
Synonym: Congenital Abnormality of the Genitourinary System
Synonym: Congenital Genitourinary Abnormality
Synonym: Congenital Urogenital Malformations
Tree Number: T3.14
database_cross_reference: COSTAR:U000322
database_cross_reference: CST:ANOMALY CONGEN UG
database_cross_reference: DO:DOID:2038
database_cross_reference: HPO:HP:0000119
database_cross_reference: MDR:10002625
database_cross_reference: MDR:10046692
database_cross_reference: MDR:10046693
database_cross_reference: MDR:10046699
database_cross_reference: MDR:10046700
database_cross_reference: MDR:10062334
database_cross_reference: MSH:D014564
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35107
database_cross_reference: NCI_NICHD:C35107
database_cross_reference: NDFRT:N0000003083
database_cross_reference: RCD:Xa3ha
database_cross_reference: RCD:Xa3hb
database_cross_reference: SNM:M-23000
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-70100
database_cross_reference: SNOMEDCT_US:12537003
database_cross_reference: SNOMEDCT_US:156962009
database_cross_reference: SNOMEDCT_US:156981001
database_cross_reference: SNOMEDCT_US:287085006
database_cross_reference: SNOMEDCT_US:287086007

Menorrhagia
type: Class
subclass of: Abnormal bleeding
definition: Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days.
PMOID: PMO:00000916
Subclass_of: Abnormal bleeding
Synonym: Abnormally heaving bleeding during menstruation
Synonym: BLEEDING MENSTRUAL HEAVY
Synonym: Bleeding menstrual heavy
Synonym: EXCESSIVE MENSES
Synonym: Excessive menstruation
Synonym: Flooding during periods
Synonym: HYPERMENORRHEA
Synonym: Heavy menstrual period
Synonym: Heavy menstrual period (finding)
Synonym: Heavy period
Tree Number: T3.2.1.9
database_cross_reference: BI:BI00393
database_cross_reference: CHV:0000007949
database_cross_reference: COSTAR:480
database_cross_reference: COSTAR:U000282
database_cross_reference: COSTAR:U000368
database_cross_reference: CSP:1138-6273
database_cross_reference: CST:MENORRHAGIA
database_cross_reference: DXP:U002548
database_cross_reference: HPO:HP:0000132
database_cross_reference: ICD10CM:N92.0
database_cross_reference: ICPC2EENG:X06
database_cross_reference: ICPC2P:X06002
database_cross_reference: ICPC2P:X06005
database_cross_reference: ICPC2P:X06006
database_cross_reference: LCH:U002904
database_cross_reference: LCH_NW:sh85083593
database_cross_reference: MDR:10005123
database_cross_reference: MDR:10015606
database_cross_reference: MDR:10019360
database_cross_reference: MDR:10020672
database_cross_reference: MDR:10020673
database_cross_reference: MDR:10027313
database_cross_reference: MDR:10027322
database_cross_reference: MDR:10027332
database_cross_reference: MDR:10027338
database_cross_reference: MDR:10036867
database_cross_reference: MEDCIN:598
database_cross_reference: MEDCIN:99225
database_cross_reference: MSH:D008595
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:626.2
database_cross_reference: NCI:C26829
database_cross_reference: NCI_CTCAE:E13132
database_cross_reference: NCI_NCI-GLOSS:CDR0000256569
database_cross_reference: NCI_NICHD:C26829
database_cross_reference: NDFRT:N0000001993
database_cross_reference: OMIM:MTHU009110
database_cross_reference: RCD:K5920
database_cross_reference: RCD:XE0eo
database_cross_reference: RCD:Xa4dw
database_cross_reference: RCDAE:XE0eo
database_cross_reference: SNM:F-30170
database_cross_reference: SNMI:F-81170
database_cross_reference: SNOMEDCT_US:123348000
database_cross_reference: SNOMEDCT_US:156038002
database_cross_reference: SNOMEDCT_US:198418008
database_cross_reference: SNOMEDCT_US:289888001
database_cross_reference: SNOMEDCT_US:386692008
database_cross_reference: SNOMEDCT_US:63515003

Abnormality of head or neck
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of head and neck.
PMOID: PMO:00001365
Subclass_of: Phenotypic Abnormality
Synonym: Head and neck abnormality
Tree Number: T3.4
database_cross_reference: HPO:HP:0000152

Gingival bleeding
type: Class
subclass of: Abnormal bleeding
definition: Hemorrhage affecting the gingiva.
PMOID: PMO:00000915
Subclass_of: Abnormal bleeding
Synonym: Bleeding gums
Synonym: Bleeding of subgingival space
Synonym: Bleeding of subgingival space (disorder)
Synonym: Crevicular bleeding of gum
Synonym: Gingival crevice bleeding
Synonym: Gingival crevicular bleeding
Synonym: Gingival hemorrhage
Synonym: Gingivorrhagia
Tree Number: T3.2.1.8
database_cross_reference: HPO:HP:0000225
database_cross_reference: SNOMEDCT_US:109616007
database_cross_reference: SNOMEDCT_US:86276007

Abnormality of the head
type: Class
subclass of: Abnormality of head or neck
definition: An abnormality of the head.
PMOID: PMO:00001366
Subclass_of: Abnormality of head or neck
Synonym: Abnormal head
Synonym: Head abnormality
Tree Number: T3.4.1
database_cross_reference: HPO:HP:0000234

Abnormality of the face
type: Class
subclass of: Abnormality of the head
definition: An abnormality of the face.
PMOID: PMO:00001367
Subclass_of: Abnormality of the head
Synonym: Abnormal face
Synonym: Abnormality of the countenance
Synonym: Abnormality of the physiognomy
Synonym: Abnormality of the visage
Synonym: Anomaly of face
Synonym: Facial abnormality
Synonym: Facial anomaly
Tree Number: T3.4.1.1
database_cross_reference: HPO:HP:0000271

Abnormality of facial adipose tissue
type: Class
subclass of: Abnormal adipose tissue morphology
PMOID: PMO:00001261
Subclass_of: Abnormal adipose tissue morphology
Synonym: Abnormality of facial fat
Synonym: Deformity of facial adipose tissue
Synonym: Malformation of facial adipose tissue
Tree Number: T3.3.1.1
database_cross_reference: HPO:HP:0000291

Abnormality of the outer ear
type: Class
subclass of: Abnormal ear morphology
definition: An abnormality of the external ear.
PMOID: PMO:00005911
Subclass_of: Abnormal ear morphology
Synonym: Abnormal pinnae
Synonym: Abnormality of the auricle
Synonym: External ear malformation
Synonym: External ear malformations
Synonym: Malformed pinnae
Synonym: Outer ear abnormality
Tree Number: T3.11.1.3
database_cross_reference: HPO:HP:0000356
database_cross_reference: HPO:HP:0008572
database_cross_reference: OMIM:MTHU000093
database_cross_reference: OMIM:MTHU003467
database_cross_reference: OMIM:MTHU019198

Abnormality of the inner ear
type: Class
subclass of: Abnormal ear morphology
definition: An abnormality of the inner ear.
PMOID: PMO:00005827
Subclass_of: Abnormal ear morphology
Synonym: Inner ear abnormality
Tree Number: T3.11.1.1
database_cross_reference: HPO:HP:0000359

Hearing abnormality
type: Class
subclass of: Abnormal ear physiology
definition: An abnormality of the sensory perception of sound.
PMOID: PMO:00006067
Subclass_of: Abnormal ear physiology
Synonym: Abnormal hearing
Tree Number: T3.11.2.1
database_cross_reference: HPO:HP:0000364

Abnormality of the middle ear
type: Class
subclass of: Abnormal ear morphology
definition: An abnormality of the middle ear.
PMOID: PMO:00005873
Subclass_of: Abnormal ear morphology
Synonym: Middle ear abnormalities
Synonym: Middle ear abnormality
Tree Number: T3.11.1.2
database_cross_reference: HPO:HP:0000370

Abnormality of the neck
type: Class
subclass of: Abnormality of head or neck
definition: An abnormality of the neck.
PMOID: PMO:00002473
Subclass_of: Abnormality of head or neck
Synonym: 4-B2 CONGENITAL ANOMALIES OF THE NECK
Synonym: Anomaly of the neck
Synonym: CONGENITAL ANOMALIES OF THE NECK
Synonym: Congenital anomaly of neck
Synonym: Congenital anomaly of neck (disorder)
Synonym: Congenital anomaly of neck NOS
Synonym: Congenital anomaly of neck NOS (disorder)
Synonym: Congenital anomaly of neck, NOS
Synonym: Congenital deformity of neck
Synonym: Congenital deformity of neck, NOS
Tree Number: T3.4.2
database_cross_reference: HPO:HP:0000464
database_cross_reference: RCD:P4z0.
database_cross_reference: RCD:X77tS
database_cross_reference: SNMI:D4-B2000
database_cross_reference: SNOMEDCT_US:156903001
database_cross_reference: SNOMEDCT_US:204288007
database_cross_reference: SNOMEDCT_US:268311006
database_cross_reference: SNOMEDCT_US:40052002

Webbed neck
type: Class
subclass of: Abnormality of the neck
definition: Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline.
PMOID: PMO:00002492
Subclass_of: Abnormality of the neck
Synonym: Congenital neck webbing unsp.
Synonym: Congenital neck webbing, unspecified
Synonym: Congenital neck webbing, unspecified (disorder)
Synonym: Congenital webbing of neck
Synonym: Congenital webbing of neck (disorder)
Synonym: Congenital webbing of neck NOS
Synonym: Congenital webbing of neck NOS (disorder)
Synonym: NECK WEBBED
Synonym: Neck Webbing
Synonym: Neck webbing
Tree Number: T3.4.2.10
database_cross_reference: CHV:0000021345
database_cross_reference: DXP:U002784
database_cross_reference: HPO:HP:0000465
database_cross_reference: ICD10:Q18.3
database_cross_reference: ICD10AM:Q18.3
database_cross_reference: ICD10CM:Q18.3
database_cross_reference: ICD9CM:744.5
database_cross_reference: MDR:10047876
database_cross_reference: MDR:10051972
database_cross_reference: MEDCIN:6961
database_cross_reference: MEDCIN:98996
database_cross_reference: MTHICD9:744.5
database_cross_reference: NCI:C87130
database_cross_reference: NCI_NICHD:C87130
database_cross_reference: OMIM:MTHU036403
database_cross_reference: OMIM:MTHU036551
database_cross_reference: OMIM:MTHU038333
database_cross_reference: OMIM:MTHU048699
database_cross_reference: RCD:P45..
database_cross_reference: RCD:P450.
database_cross_reference: RCD:P45z.
database_cross_reference: RCD:X76gB
database_cross_reference: SNM:M-25120
database_cross_reference: SNMI:D4-B2050
database_cross_reference: SNOMEDCT_US:11731003
database_cross_reference: SNOMEDCT_US:204279003
database_cross_reference: SNOMEDCT_US:204280000
database_cross_reference: SNOMEDCT_US:204281001
database_cross_reference: SNOMEDCT_US:249667006
database_cross_reference: SNOMEDCT_US:271281009

Increased adipose tissue around the neck
type: Class
subclass of: Abnormality of the neck
definition: An increased amount of subcutaneous fat tissue around the neck.
PMOID: PMO:00002482
Subclass_of: Abnormality of the neck
Synonym: Increased fat around the neck
Tree Number: T3.4.2.4
database_cross_reference: HPO:HP:0000468

Short neck
type: Class
subclass of: Abnormality of the neck
definition: Diminished length of the neck.
PMOID: PMO:00002490
Subclass_of: Abnormality of the neck
Synonym: Cervical shortening
Synonym: Decreased cervical height
Synonym: Decreased cervical length
Synonym: Decreased length of neck
Tree Number: T3.4.2.8
database_cross_reference: HPO:HP:0000470

Long neck
type: Class
subclass of: Abnormality of the neck
definition: Increased inferior-superior length of the neck.
PMOID: PMO:00002488
Subclass_of: Abnormality of the neck
Synonym: Cervical elongation
Synonym: Elongated neck
Synonym: Increased cervical length
Synonym: Increased length of neck
Tree Number: T3.4.2.6
database_cross_reference: HPO:HP:0000472

Thickened nuchal skin fold
type: Class
subclass of: Abnormality of the neck
definition: A thickening of the skin thickness in the posterior aspect of the fetal neck. A nuchal fold measurement is obtained in a transverse section of the fetal head at the level of the cavum septum pellucidum and thalami, angled posteriorly to include the cerebellum. The measurement is taken from the outer edge of the occiput bone to the outer skin limit directly in the midline. A measurement 6 mm or more is considered significant between 18 and 24 weeks and a measurement of 5 mm or more is considered significant at 16 to 18 weeks (pmid:16100637).
PMOID: PMO:00002491
Subclass_of: Abnormality of the neck
Synonym: Excess nuchal skin
Synonym: Thickened nuchal skin
Synonym: Thickened skin folds of neck
Synonym: Thickened skin over the neck
Tree Number: T3.4.2.9
database_cross_reference: HPO:HP:0000474

Broad neck
type: Class
subclass of: Abnormality of the neck
definition: Increased side-to-side width of the neck.
PMOID: PMO:00002478
Subclass_of: Abnormality of the neck
Synonym: Increased width of neck
Synonym: Wide neck
Tree Number: T3.4.2.2
database_cross_reference: HPO:HP:0000475

Cystic hygroma
type: Class
subclass of: Abnormality of the neck
definition: A cystic lymphatic lesion of the neck.
PMOID: PMO:00002479
Subclass_of: Abnormality of the neck
Synonym: CYSTIC HYGROMA
Synonym: Colli, Cystic Hygroma
Synonym: Cystic Hygroma
Synonym: Cystic Hygroma Colli
Synonym: Cystic Hygromas
Synonym: Cystic Lymphangioma
Synonym: Cystic Lymphangiomas
Synonym: Cystic hygroma (disorder)
Synonym: Cystic hygroma of the neck
Synonym: Cystic lymphangioma
Tree Number: T3.4.2.3
database_cross_reference: CCPSS:0059029
database_cross_reference: CHV:0000020973
database_cross_reference: DO:DOID:3081
database_cross_reference: HPO:HP:0000476
database_cross_reference: ICD10AM:M9173/0
database_cross_reference: ICPC2P:K72008
database_cross_reference: ICPC2P:K99048
database_cross_reference: MDR:10011769
database_cross_reference: MDR:10020543
database_cross_reference: MDR:10058949
database_cross_reference: MEDCIN:362060
database_cross_reference: MSH:D018191
database_cross_reference: NCI:C3724
database_cross_reference: NCI_NICHD:C3724
database_cross_reference: NDFRT:N0000003665
database_cross_reference: OMIM:MTHU014835
database_cross_reference: RCD:BBU4.
database_cross_reference: SNM:M-9173/0
database_cross_reference: SNMI:M-91730
database_cross_reference: SNOMEDCT_US:399882002
database_cross_reference: SNOMEDCT_US:40225001
database_cross_reference: SNOMEDCT_US:423984004

Abnormality of the eye
type: Class
subclass of: Phenotypic Abnormality
definition: Any abnormality of the eye, including location, spacing, and intraocular abnormalities.
PMOID: PMO:00006419
Subclass_of: Phenotypic Abnormality
Synonym: Abnormal eye
Synonym: Abnormalities, Eye
Synonym: Abnormality, Eye
Synonym: CONGENITAL ANOMALIES OF THE EYE AND ORBIT
Synonym: Congenital Diseases and Syndromes of Eye
Synonym: Congenital Eye Disorder
Synonym: Congenital Ophthalmologic Abnormality
Synonym: Congenital abnormality of eye
Synonym: Congenital abnormality of eye (disorder)
Synonym: Congenital anolmaly of eye
Tree Number: T3.13
database_cross_reference: CCPSS:0016777
database_cross_reference: CCPSS:0059393
database_cross_reference: CHV:0000004811
database_cross_reference: CHV:0000038687
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000466
database_cross_reference: COSTAR:U000488
database_cross_reference: CSP:0724-2798
database_cross_reference: CST:ANOMALY CONGEN SS
database_cross_reference: CST:EYE DIS
database_cross_reference: HPO:HP:0000478
database_cross_reference: ICD10:Q15.9
database_cross_reference: ICD10AM:Q15.9
database_cross_reference: ICD10CM:Q15.9
database_cross_reference: ICD9CM:743
database_cross_reference: ICD9CM:743.9
database_cross_reference: ICPC2P:F81001
database_cross_reference: LCH_NW:sh85046643
database_cross_reference: MDR:10010343
database_cross_reference: MDR:10010435
database_cross_reference: MDR:10010462
database_cross_reference: MDR:10015903
database_cross_reference: MDR:10015904
database_cross_reference: MDR:10015913
database_cross_reference: MDR:10015920
database_cross_reference: MDR:10015949
database_cross_reference: MDR:10045628
database_cross_reference: MDR:10048513
database_cross_reference: MDR:10059159
database_cross_reference: MEDCIN:211191
database_cross_reference: MSH:D005124
database_cross_reference: MTHICD9:743.9
database_cross_reference: NCI:C98887
database_cross_reference: NDFRT:N0000001179
database_cross_reference: OMIM:MTHU040178
database_cross_reference: RCD:P3...
database_cross_reference: RCD:P3z..
database_cross_reference: RCD:X77sF
database_cross_reference: SNM:D-X250
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-A0000
database_cross_reference: SNOMEDCT_US:156897005
database_cross_reference: SNOMEDCT_US:156902006
database_cross_reference: SNOMEDCT_US:19416009
database_cross_reference: SNOMEDCT_US:204222005
database_cross_reference: SNOMEDCT_US:231789000
database_cross_reference: SNOMEDCT_US:253210009
database_cross_reference: SNOMEDCT_US:268310007

Abnormality of eye movement
type: Class
subclass of: Abnormal eye physiology
definition: An abnormality in voluntary or involuntary eye movements or their control.
PMOID: PMO:00007103
Subclass_of: Abnormal eye physiology
Synonym: Abnormal extraocular movement
Synonym: Abnormal extraocular movements
Synonym: Abnormal eye motility
Synonym: Abnormal eye movement
Synonym: Abnormal eye movements
Synonym: Abnormal motility of the globe of the eye
Synonym: Abnormal movement of the globe of the eye
Synonym: Abnormal ocular movements
Synonym: Eye movement abnormalities
Synonym: Eye movement issue
Tree Number: T3.13.2.6
database_cross_reference: HPO:HP:0000496

Glaucoma
type: Class
subclass of: Abnormal eye physiology
definition: Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure.
PMOID: PMO:00007439
Subclass_of: Abnormal eye physiology
Synonym: A-730-733 GLAUCOMAS
Synonym: GLAUCOMA
Synonym: GLAUCOMAS
Synonym: Glaucoma (H40-H42)
Synonym: Glaucoma (disorder)
Synonym: Glaucoma NOS
Synonym: Glaucoma NOS (disorder)
Synonym: Glaucoma [Disease/Finding]
Synonym: Glaucoma syndrome
Synonym: Glaucoma, NOS
Tree Number: T3.13.2.11
database_cross_reference: AOD:0000006031
database_cross_reference: BI:BI00013
database_cross_reference: CCPSS:0043103
database_cross_reference: CHV:0000005514
database_cross_reference: COSTAR:331
database_cross_reference: CSP:1114-9010
database_cross_reference: CST:GLAUCOMA
database_cross_reference: DO:DOID:1686
database_cross_reference: DXP:U001708
database_cross_reference: HPO:HP:0000501
database_cross_reference: ICD10:H40
database_cross_reference: ICD10:H40-H42.9
database_cross_reference: ICD10:H40.9
database_cross_reference: ICD10AM:H40
database_cross_reference: ICD10AM:H40-H42.9
database_cross_reference: ICD10AM:H40.9
database_cross_reference: ICD10CM:H40
database_cross_reference: ICD10CM:H40-H42
database_cross_reference: ICD10CM:H40.9
database_cross_reference: ICD9CM:365
database_cross_reference: ICD9CM:365.9
database_cross_reference: ICPC2EENG:F93
database_cross_reference: ICPC2P:F93001
database_cross_reference: LCH:U001972
database_cross_reference: LCH_NW:sh85055227
database_cross_reference: LNC:LA16302-4
database_cross_reference: LNC:MTHU020819
database_cross_reference: MDR:10018304
database_cross_reference: MDR:10018326
database_cross_reference: MDR:10018332
database_cross_reference: MDR:10045894
database_cross_reference: MEDCIN:30746
database_cross_reference: MEDLINEPLUS:42
database_cross_reference: MSH:D005901
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26782
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_CTCAE:E10392
database_cross_reference: NCI_FDA:1875
database_cross_reference: NCI_NCI-GLOSS:CDR0000534224
database_cross_reference: NCI_NICHD:C26782
database_cross_reference: NDFRT:N0000001345
database_cross_reference: OMIM:MTHU004639
database_cross_reference: PSY:21090
database_cross_reference: RCD:F45..
database_cross_reference: RCD:F45z.
database_cross_reference: SNM:D-X300
database_cross_reference: SNM:U000025
database_cross_reference: SNMI:DA-73000
database_cross_reference: SNOMEDCT_US:155120009
database_cross_reference: SNOMEDCT_US:193569008
database_cross_reference: SNOMEDCT_US:194631001
database_cross_reference: SNOMEDCT_US:23986001

Abnormality of vision
type: Class
subclass of: Abnormal eye physiology
definition: Abnormality of eyesight (visual perception).
PMOID: PMO:00007284
Subclass_of: Abnormal eye physiology
Synonym: Abnormality of sight
Tree Number: T3.13.2.8
database_cross_reference: HPO:HP:0000504

Ptosis
type: Class
subclass of: Abnormal eye physiology
definition: The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective).
PMOID: PMO:00007476
Subclass_of: Abnormal eye physiology
Synonym: BLEPHAROPTOSIS
Synonym: Blepharoptoses
Synonym: Blepharoptosis
Synonym: Blepharoptosis [Disease/Finding]
Synonym: Drooping eyelid
Synonym: Drooping upper eyelid
Synonym: Drooping;eyelid
Synonym: Droopy eyelid
Synonym: Droopy eyelids
Synonym: Eyelid Ptoses
Tree Number: T3.13.2.14
database_cross_reference: CCPSS:0033071
database_cross_reference: CHV:0000001973
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:PTOSIS
database_cross_reference: DO:DOID:0060260
database_cross_reference: HPO:HP:0000508
database_cross_reference: ICD10:H02.4
database_cross_reference: ICD10AM:H02.4
database_cross_reference: ICD10CM:H02.4
database_cross_reference: ICD10CM:H02.40
database_cross_reference: ICD10CM:H02.409
database_cross_reference: ICD9CM:374.3
database_cross_reference: ICD9CM:374.30
database_cross_reference: ICPC2P:F16002
database_cross_reference: ICPC2P:F16005
database_cross_reference: LCH:U000606
database_cross_reference: LCH_NW:sh85014843
database_cross_reference: MDR:10005157
database_cross_reference: MDR:10015995
database_cross_reference: MDR:10037273
database_cross_reference: MDR:10037274
database_cross_reference: MEDCIN:2042
database_cross_reference: MEDCIN:36768
database_cross_reference: MEDCIN:6436
database_cross_reference: MEDLINEPLUS:5404
database_cross_reference: MSH:D001763
database_cross_reference: MTH:U001745
database_cross_reference: NCI:C27298
database_cross_reference: NCI_FDA:2620
database_cross_reference: NCI_NCI-GLOSS:CDR0000044081
database_cross_reference: NCI_NICHD:C27298
database_cross_reference: NDFRT:N0000000570
database_cross_reference: OMIM:MTHU000509
database_cross_reference: OMIM:MTHU000860
database_cross_reference: OMIM:MTHU038613
database_cross_reference: OMIM:MTHU039308
database_cross_reference: RCD:F4E30
database_cross_reference: RCD:F4E3z
database_cross_reference: RCD:XM050
database_cross_reference: SNM:M-31050
database_cross_reference: SNMI:DA-76330
database_cross_reference: SNOMEDCT_US:11934000
database_cross_reference: SNOMEDCT_US:155179008
database_cross_reference: SNOMEDCT_US:193942002
database_cross_reference: SNOMEDCT_US:193943007
database_cross_reference: SNOMEDCT_US:193945000
database_cross_reference: SNOMEDCT_US:204197004
database_cross_reference: SNOMEDCT_VET:11934000

Abnormality of refraction
type: Class
subclass of: Abnormal eye physiology
definition: An abnormality in the process of focusing of light by the eye in order to produce a sharp image on the retina.
PMOID: PMO:00007261
Subclass_of: Abnormal eye physiology
Tree Number: T3.13.2.7
database_cross_reference: HPO:HP:0000539

Abnormal uvea morphology
type: Class
subclass of: Abnormal eye morphology
definition: An abnormality of the uvea, the vascular layer of the eyeball.
PMOID: PMO:00006920
Subclass_of: Abnormal eye morphology
Tree Number: T3.13.1.4

Coloboma
type: Class
subclass of: Abnormal eye morphology
definition: A developmental defect characterized by a cleft of some portion of the eye or ocular adnexa.
PMOID: PMO:00006991
Subclass_of: Abnormal eye morphology
Synonym: COI
Synonym: COI - Coloboma iris/chor/retin
Synonym: COI - Coloboma of iris, choroid and retina
Synonym: COLOBOMA
Synonym: COLOBOMA OF IRIS, CHOROID, AND RETINA
Synonym: COLOBOMA, OCULAR
Synonym: COLOBOMA, OCULAR, AUTOSOMAL DOMINANT
Synonym: COLOBOMA, UVEORETINAL
Synonym: Coloboma NOS
Synonym: Coloboma Of Iris, Choroid, And Retina
Tree Number: T3.13.1.9
database_cross_reference: CCPSS:1017416
database_cross_reference: CHV:0000003167
database_cross_reference: DO:DOID:12270
database_cross_reference: HPO:HP:0000589
database_cross_reference: ICD10CM:Q13.0
database_cross_reference: MDR:10009934
database_cross_reference: MDR:10009937
database_cross_reference: MEDCIN:11534
database_cross_reference: MEDCIN:211196
database_cross_reference: MEDCIN:360537
database_cross_reference: MSH:D003103
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C98877
database_cross_reference: NDFRT:N0000000810
database_cross_reference: OMIM:120200
database_cross_reference: OMIM:606522
database_cross_reference: OMIM:606608
database_cross_reference: OMIM:MTHU003777
database_cross_reference: OMIM:MTHU012405
database_cross_reference: OMIM:MTHU019860
database_cross_reference: OMIM:MTHU026213
database_cross_reference: OMIM:MTHU026549
database_cross_reference: OMIM:MTHU042339
database_cross_reference: RCD:X77st
database_cross_reference: SNM:M-20190
database_cross_reference: SNMI:D4-A0006
database_cross_reference: SNMI:DA-70340
database_cross_reference: SNOMEDCT_US:92828000
database_cross_reference: SNOMEDCT_US:93390002

Abnormal sclera morphology
type: Class
subclass of: Abnormal eye morphology
definition: An abnormality of the sclera.
PMOID: PMO:00006909
Subclass_of: Abnormal eye morphology
Synonym: Abnormality of the sclera
Tree Number: T3.13.1.3
database_cross_reference: HPO:HP:0000591

Abnormality of the ear
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the ear.
PMOID: PMO:00005825
Subclass_of: Phenotypic Abnormality
Synonym: 4-B0 CONGENITAL ANOMALIES OF THE EAR
Synonym: Abnormality of the external ear
Synonym: CONGENITAL ANOMALIES OF THE EAR
Synonym: Congenital abnormality of ear
Synonym: Congenital anomaly of ear
Synonym: Congenital anomaly of ear (disorder)
Synonym: Congenital anomaly of ear NOS
Synonym: Congenital anomaly of ear, NOS
Synonym: Congenital anomaly;ear
Synonym: Congenital deformity of ear
Tree Number: T3.11
database_cross_reference: CCPSS:0023368
database_cross_reference: CHV:0000026070
database_cross_reference: CST:ANOMALY CONGEN
database_cross_reference: HPO:HP:0000356
database_cross_reference: HPO:HP:0000598
database_cross_reference: ICD10:Q17.9
database_cross_reference: ICD10AM:Q17.9
database_cross_reference: ICD10CM:Q17.9
database_cross_reference: ICD9CM:744.3
database_cross_reference: ICPC2EENG:H80
database_cross_reference: ICPC2P:H80004
database_cross_reference: MDR:10010451
database_cross_reference: MDR:10014016
database_cross_reference: MDR:10014017
database_cross_reference: MDR:10045698
database_cross_reference: MEDCIN:34548
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:744.3
database_cross_reference: OMIM:128600
database_cross_reference: OMIM:MTHU006799
database_cross_reference: OMIM:MTHU034021
database_cross_reference: OMIM:MTHU053647
database_cross_reference: RCD:P43..
database_cross_reference: RCD:X77tA
database_cross_reference: RCD:XM1MC
database_cross_reference: SNMI:D4-B0000
database_cross_reference: SNOMEDCT_US:156903001
database_cross_reference: SNOMEDCT_US:156906009
database_cross_reference: SNOMEDCT_US:204262009
database_cross_reference: SNOMEDCT_US:268311006
database_cross_reference: SNOMEDCT_US:268312004
database_cross_reference: SNOMEDCT_US:275259005
database_cross_reference: SNOMEDCT_US:8380000

Abnormality of the pharynx
type: Class
subclass of: Abnormality of the head
definition: An anomaly of the pharynx, i.e., of the tubular structure extending from the base of the skull superiorly to the esophageal inlet inferiorly.
PMOID: PMO:00002216
Subclass_of: Abnormality of the head
Tree Number: T3.4.1.2
database_cross_reference: HPO:HP:0000600

Lacrimation abnormality
type: Class
subclass of: Abnormal eye physiology
definition: Abnormality of tear production.
PMOID: PMO:00007466
Subclass_of: Abnormal eye physiology
Synonym: Abnormality of tear production
Tree Number: T3.13.2.13
database_cross_reference: HPO:HP:0000632

Phthisis bulbi
type: Class
subclass of: Abnormal eye morphology
definition: Atrophy of the eyeball with blindness and decreased intraocular pressure due to end-stage intraocular disease.
PMOID: PMO:00007000
Subclass_of: Abnormal eye morphology
Synonym: Atrophia bulbi
Synonym: Atrophy of eye
Synonym: Atrophy of globe
Synonym: Atrophy of globe, unspecified eye
Synonym: Eyeball atrophic
Synonym: Globe of eye shrunken
Synonym: Globe of eye shrunken (disorder)
Synonym: Globe of eye shrunken (finding)
Synonym: PHTHISIS BULBI
Synonym: Phthisical eye
Tree Number: T3.13.1.10
database_cross_reference: CCPSS:0023942
database_cross_reference: CHV:0000026570
database_cross_reference: HPO:HP:0000667
database_cross_reference: ICD10CM:H44.52
database_cross_reference: ICD10CM:H44.529
database_cross_reference: MDR:10065684
database_cross_reference: MDR:10067488
database_cross_reference: MEDCIN:273872
database_cross_reference: MEDCIN:36435
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:360.41
database_cross_reference: OMIM:MTHU037383
database_cross_reference: RCD:F4041
database_cross_reference: RCD:X75hP
database_cross_reference: SNM:M-58500
database_cross_reference: SNMI:DA-70412
database_cross_reference: SNMI:DA-70414
database_cross_reference: SNOMEDCT_US:111510002
database_cross_reference: SNOMEDCT_US:246922000
database_cross_reference: SNOMEDCT_US:4229009

Abnormality of the nervous system
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the nervous system.
PMOID: PMO:00009759
Subclass_of: Phenotypic Abnormality
Synonym: 4-90 CONGENITAL ANOMALIES OF THE NERVOUS SYSTEM: GENERAL TERMS
Synonym: ABNORM CONGEN NERVOUS SYSTEM
Synonym: ABNORM NERVOUS SYSTEM
Synonym: Abnormalities, Congenital, Nervous System
Synonym: Abnormalities, Nervous System
Synonym: Abnormality, Nervous System
Synonym: Anomalies, Nervous System
Synonym: Anomaly, Nervous System
Synonym: CONGEN ABNORM NERVOUS SYSTEM
Synonym: CONGEN ANOMALIES NERVOUS SYSTEM
Tree Number: T3.18
database_cross_reference: AOD:0000006232
database_cross_reference: CSP:0725-4145
database_cross_reference: HPO:HP:0000707
database_cross_reference: ICD10:Q00-Q07.9
database_cross_reference: ICD10:Q07.9
database_cross_reference: ICD10AM:Q00-Q07.9
database_cross_reference: ICD10AM:Q07.9
database_cross_reference: ICD10CM:Q00-Q07
database_cross_reference: ICD10CM:Q07.9
database_cross_reference: ICD9CM:742.9
database_cross_reference: ICPC2EENG:N85
database_cross_reference: ICPC2P:N85004
database_cross_reference: LCH_NW:sh85090918
database_cross_reference: MDR:10045694
database_cross_reference: MEDCIN:335155
database_cross_reference: MSH:D009421
database_cross_reference: MTH:U001554
database_cross_reference: MTHICD9:742.9
database_cross_reference: NCI:C97172
database_cross_reference: NCI_NICHD:C97172
database_cross_reference: NDFRT:N0000002158
database_cross_reference: RCD:P2y..
database_cross_reference: RCD:P2yz.
database_cross_reference: RCD:P2z..
database_cross_reference: RCD:Pyu0.
database_cross_reference: RCD:X00Ef
database_cross_reference: RCDSY:Pyu0.
database_cross_reference: SNMI:D4-90000
database_cross_reference: SNOMEDCT_US:204093003
database_cross_reference: SNOMEDCT_US:204096006
database_cross_reference: SNOMEDCT_US:204097002
database_cross_reference: SNOMEDCT_US:205845004
database_cross_reference: SNOMEDCT_US:88425004

Behavioral abnormality
type: Class
subclass of: Abnormality of nervous system physiology
definition: An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities.
PMOID: PMO:00011040
Subclass_of: Abnormality of nervous system physiology
Synonym: Abnormal Behavior
Synonym: Abnormal behavior
Synonym: Abnormal behavior (finding)
Synonym: Abnormal behavior NOS
Synonym: Abnormal behavior, NOS
Synonym: Abnormal behaviour
Synonym: Abnormal behaviour NOS
Synonym: Abnormal conduct
Synonym: Abnormal conduct, NOS
Synonym: BEHAVIOR ABNORMAL
Tree Number: T3.18.3.11
database_cross_reference: AOD:0000006422
database_cross_reference: AOD:0000023690
database_cross_reference: CCPSS:0063207
database_cross_reference: CHV:0000023127
database_cross_reference: CHV:0000025345
database_cross_reference: CHV:0000025346
database_cross_reference: COSTAR:U000067
database_cross_reference: COSTAR:U000068
database_cross_reference: CST:PERSON DIS
database_cross_reference: HPO:HP:0000708
database_cross_reference: MDR:10000118
database_cross_reference: MDR:10004203
database_cross_reference: MDR:10004206
database_cross_reference: MDR:10061422
database_cross_reference: MEDCIN:112189
database_cross_reference: MSH:D000066553
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C122430
database_cross_reference: NCI_NICHD:C122430
database_cross_reference: OMIM:MTHU000244
database_cross_reference: OMIM:MTHU007827
database_cross_reference: OMIM:MTHU008026
database_cross_reference: OMIM:MTHU012413
database_cross_reference: OMIM:MTHU030536
database_cross_reference: OMIM:MTHU051770
database_cross_reference: OMIM:MTHU053441
database_cross_reference: PSY:05650
database_cross_reference: RCD:Xa0Xh
database_cross_reference: RCDAE:Xa0Xh
database_cross_reference: SNM:F-91010
database_cross_reference: SNM:F-94010
database_cross_reference: SNMI:F-93010
database_cross_reference: SNOMEDCT_US:25786006
database_cross_reference: SNOMEDCT_US:277843001

Abnormal peripheral nervous system morphology
type: Class
subclass of: Abnormality of nervous system morphology
definition: An abnormality of the peripheral nervous system, which is composed of the nerves that lead to or branch off from the central nervous system. This includes the cranial nerves (olfactory and optic nerves are technically part of the central nervous system).
PMOID: PMO:00009802
Subclass_of: Abnormality of nervous system morphology
Tree Number: T3.18.2.3
database_cross_reference: HPO:HP:0000759

Abnormality of the breast
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the breast.
PMOID: PMO:00004415
Subclass_of: Phenotypic Abnormality
Tree Number: T3.8
database_cross_reference: HPO:HP:0000769

Gynecomastia
type: Class
subclass of: Abnormal breast morphology
definition: Abnormal development of large mammary glands in males resulting in breast enlargement.
PMOID: PMO:00004436
Subclass_of: Abnormal breast morphology
Synonym: BREAST ENLARGEMENT MALE
Synonym: Breast Enlargement, Male
Synonym: Breast enlargement male
Synonym: ENLARGEMENT BREAST MALE
Synonym: Enlargement breast male
Synonym: Enlargement, Male Breast
Synonym: GYNAECOMASTIA
Synonym: GYNECOMASTIA
Synonym: Gynaecomastia
Synonym: Gynaecomazia
Tree Number: T3.8.1.5
database_cross_reference: AOD:0000004462
database_cross_reference: BI:BI00342
database_cross_reference: CCPSS:1005810
database_cross_reference: CHV:0000005746
database_cross_reference: COSTAR:340
database_cross_reference: CSP:2587-5894
database_cross_reference: CST:GYNECOMASTIA
database_cross_reference: DO:DOID:12698
database_cross_reference: DXP:U001755
database_cross_reference: HPO:HP:0000771
database_cross_reference: ICD10CM:N62
database_cross_reference: ICPC2P:Y16005
database_cross_reference: ICPC2P:Y99011
database_cross_reference: MDR:10006244
database_cross_reference: MDR:10014844
database_cross_reference: MDR:10018800
database_cross_reference: MDR:10018801
database_cross_reference: MEDCIN:283172
database_cross_reference: MEDCIN:332421
database_cross_reference: MEDLINEPLUS:474
database_cross_reference: MSH:D006177
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:611.1
database_cross_reference: NCI:C3073
database_cross_reference: NCI_CTCAE:E13115
database_cross_reference: NCI_NICHD:C3073
database_cross_reference: NDFRT:N0000001396
database_cross_reference: OMIM:MTHU006965
database_cross_reference: RCD:XE0eN
database_cross_reference: RCDAE:XE0eN
database_cross_reference: SNM:M-71000
database_cross_reference: SNMI:D7-90420
database_cross_reference: SNOMEDCT_US:155963008
database_cross_reference: SNOMEDCT_US:198112004
database_cross_reference: SNOMEDCT_US:266646002
database_cross_reference: SNOMEDCT_US:4754008
database_cross_reference: SNOMEDCT_VET:311361000009109
database_cross_reference: SNOMEDCT_VET:4754008

Abnormality of the diaphragm
type: Class
subclass of: Abnormality of the musculature
definition: Any abnormality of the diaphragm, the sheet of skeletal muscle that separates the thoracic cavity from the abdominal cavity.
PMOID: PMO:00009712
Subclass_of: Abnormality of the musculature
Synonym: Diaphragm issues
Synonym: Diaphragmatic defect
Tree Number: T3.17.8
database_cross_reference: HPO:HP:0000775

Congenital diaphragmatic hernia
type: Class
subclass of: Hernia
definition: The presence of a hernia of the diaphragm present at birth.
PMOID: PMO:00001349
Subclass_of: Hernia
Synonym: DIAPHRAGMATIC HERNIA
Synonym: Diaphragmatic Hernia
Synonym: Diaphragmatic Hernias
Synonym: Diaphragmatic hernia
Synonym: Diaphragmatic hernia (disorder)
Synonym: Diaphragmatic hernia NOS
Synonym: Diaphragmatic hernia NOS (disorder)
Synonym: Diaphragmatic hernia, NOS
Synonym: Diaphragmatic hernias
Synonym: HERNIA, DIAPHRAGMATIC
Tree Number: T3.3.7.1
database_cross_reference: AOD:0000005696
database_cross_reference: CCPSS:0058559
database_cross_reference: CHV:0000006080
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:3827
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001962
database_cross_reference: ICD10:K44
database_cross_reference: ICD10AM:K44
database_cross_reference: ICD10CM:K44
database_cross_reference: ICD10CM:K44.9
database_cross_reference: ICPC2P:D90001
database_cross_reference: LCH_NW:sh85037586
database_cross_reference: MDR:10012713
database_cross_reference: MDR:10012714
database_cross_reference: MDR:10012717
database_cross_reference: MEDCIN:30146
database_cross_reference: MEDLINEPLUS:283
database_cross_reference: MSH:D006548
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34687
database_cross_reference: NCI_NICHD:C34687
database_cross_reference: NDFRT:N0000001517
database_cross_reference: OMIM:MTHU001436
database_cross_reference: RCD:J34z.
database_cross_reference: RCD:XE0ab
database_cross_reference: RCD:XE0ac
database_cross_reference: SNMI:D5-60600
database_cross_reference: SNOMEDCT_US:155748004
database_cross_reference: SNOMEDCT_US:155750007
database_cross_reference: SNOMEDCT_US:196901006
database_cross_reference: SNOMEDCT_US:196911004
database_cross_reference: SNOMEDCT_US:196912006
database_cross_reference: SNOMEDCT_US:266444006
database_cross_reference: SNOMEDCT_US:266511003
database_cross_reference: SNOMEDCT_US:39839004

Abnormality of the thymus
type: Class
subclass of: Abnormality of the endocrine system
definition: Abnormality of the thymus, an organ located in the upper anterior portion of the chest cavity just behind the sternum and whose main function is to provide an environment for T lymphocyte maturation.
PMOID: PMO:00006280
Subclass_of: Abnormality of the endocrine system
Synonym: THYMUS ABNORMALITY
Tree Number: T3.12.9
database_cross_reference: COSTAR:U000584
database_cross_reference: HPO:HP:0000777

Urinary tract atresia
type: Class
subclass of: Abnormality of the urinary system
definition: Congenital absence of the normal opening of a structure of the urinary tract.
PMOID: PMO:00008201
Subclass_of: Abnormality of the urinary system
Tree Number: T3.14.2.4
database_cross_reference: HPO:HP:0000809

Abnormality of Krebs cycle metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality of the tricarboxylic acid cycle.
PMOID: PMO:00004062
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Abnormality of citric acid cycle
Synonym: Abnormality of the tricarboxylic cycle
Tree Number: T3.6.16
database_cross_reference: HPO:HP:0000816

Abnormality of the endocrine system
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the endocrine system.
PMOID: PMO:00006108
Subclass_of: Phenotypic Abnormality
Tree Number: T3.12
database_cross_reference: HPO:HP:0000818

Diabetes mellitus
type: Class
subclass of: Abnormality of the endocrine system
definition: A group of abnormalities characterized by hyperglycemia and glucose intolerance.
PMOID: PMO:00006362
Subclass_of: Abnormality of the endocrine system
Synonym: DIABETES MELLITUS
Synonym: DIABETES MELLITUS NOS
Synonym: DIABETES MELLITUS NOS DIAGNOSED
Synonym: DM
Synonym: DM - Diabetes mellitus
Synonym: Diabetes
Synonym: Diabetes Mellitus
Synonym: Diabetes Mellitus [Disease/Finding]
Synonym: Diabetes Melllitus
Synonym: Diabetes NOS
Tree Number: T3.12.13
database_cross_reference: AOD:0000000009
database_cross_reference: AOD:0000005999
database_cross_reference: BI:BI00008
database_cross_reference: CCPSS:0031767
database_cross_reference: CCPSS:0041405
database_cross_reference: CCPSS:1018264
database_cross_reference: CHV:0000003834
database_cross_reference: COSTAR:230
database_cross_reference: CSP:0862-6160
database_cross_reference: CST:DIABETES MELL
database_cross_reference: DO:DOID:9351
database_cross_reference: DXP:U000960
database_cross_reference: HPO:HP:0000819
database_cross_reference: ICD10:E10-E14.9
database_cross_reference: ICD10:E14
database_cross_reference: ICD10AM:E10-E14.9
database_cross_reference: ICD10AM:E14
database_cross_reference: ICD10CM:E08-E13
database_cross_reference: ICD9CM:250
database_cross_reference: ICPC2P:T90002
database_cross_reference: LNC:LA14291-1
database_cross_reference: LNC:MTHU020781
database_cross_reference: MDR:10012594
database_cross_reference: MDR:10012601
database_cross_reference: MDR:10012614
database_cross_reference: MEDCIN:30479
database_cross_reference: MEDLINEPLUS:4
database_cross_reference: MEDLINEPLUS:45
database_cross_reference: MSH:D003920
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000263
database_cross_reference: MTHICD9:250.0
database_cross_reference: NCI:C2985
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044129
database_cross_reference: NCI_NCI-GLOSS:CDR0000044911
database_cross_reference: NCI_NICHD:C2985
database_cross_reference: NDFRT:N0000000950
database_cross_reference: OMIM:MTHU036798
database_cross_reference: PSY:13970
database_cross_reference: RCD:C10..
database_cross_reference: SNM:D-2381
database_cross_reference: SNMI:DB-61000
database_cross_reference: SNOMEDCT_US:154671004
database_cross_reference: SNOMEDCT_US:191044006
database_cross_reference: SNOMEDCT_US:267467004
database_cross_reference: SNOMEDCT_US:73211009

Abnormality of the thyroid gland
type: Class
subclass of: Abnormality of the endocrine system
definition: An abnormality of the thyroid gland.
PMOID: PMO:00006289
Subclass_of: Abnormality of the endocrine system
Synonym: B-80 HYPOTHYROIDISM, HYPERTHYROIDISM AND OTHER DISORDERS
Synonym: DISEASES OF THE THYROID GLAND
Synonym: DISORDER THYROID
Synonym: DISORDERS OF THYROID GLAND
Synonym: Disease of thyroid gland
Synonym: Disease of thyroid gland (disorder)
Synonym: Disease of thyroid gland, NOS
Synonym: Disease, Thyroid
Synonym: Diseases of Thyroid Gland
Synonym: Diseases of the thyroid gland
Tree Number: T3.12.10
database_cross_reference: AOD:0000005981
database_cross_reference: CCPSS:0034188
database_cross_reference: CCPSS:0056633
database_cross_reference: CHV:0000012259
database_cross_reference: CHV:0000048209
database_cross_reference: COSTAR:U000061
database_cross_reference: COSTAR:U000674
database_cross_reference: CSP:2928-6228
database_cross_reference: CST:ENDO/THYR
database_cross_reference: CST:THYR DIS
database_cross_reference: DO:DOID:12176
database_cross_reference: DO:DOID:50
database_cross_reference: HPO:HP:0000820
database_cross_reference: ICD10:E00-E07.9
database_cross_reference: ICD10:E07.9
database_cross_reference: ICD10AM:E00-E07.9
database_cross_reference: ICD10AM:E07.9
database_cross_reference: ICD10CM:E00-E07
database_cross_reference: ICD10CM:E07.9
database_cross_reference: ICD9CM:240-246.99
database_cross_reference: ICD9CM:246.9
database_cross_reference: LCH_NW:sh85135167
database_cross_reference: LNC:LA15157-3
database_cross_reference: LNC:LA17778-4
database_cross_reference: MDR:10013274
database_cross_reference: MDR:10043709
database_cross_reference: MDR:10043710
database_cross_reference: MDR:10043739
database_cross_reference: MDR:10045832
database_cross_reference: MEDCIN:90715
database_cross_reference: MEDLINEPLUS:439
database_cross_reference: MSH:D013959
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26893
database_cross_reference: NDFRT:N0000002942
database_cross_reference: OMIM:MTHU018343
database_cross_reference: OMIM:MTHU053945
database_cross_reference: PSY:53090
database_cross_reference: RCD:C06z.
database_cross_reference: RCD:XE100
database_cross_reference: SNM:D-2180
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DB-80000
database_cross_reference: SNOMEDCT_US:14304000
database_cross_reference: SNOMEDCT_US:154649009
database_cross_reference: SNOMEDCT_US:190232008
database_cross_reference: SNOMEDCT_US:190311002
database_cross_reference: SNOMEDCT_US:191036006

Delayed puberty
type: Class
subclass of: Puberty and gonadal disorders
definition: Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.
PMOID: PMO:00006402
Subclass_of: Puberty and gonadal disorders
Synonym: Constitutional Growth Delay
Synonym: DELAYED PUBERTY
Synonym: Delay in sexual development AND/OR puberty
Synonym: Delay in sexual development AND/OR puberty (disorder)
Synonym: Delay in sexual development AND/OR puberty (finding)
Synonym: Delay in sexual development and/or puberty
Synonym: Delayed Puberty
Synonym: Delayed pubertal development
Synonym: Delayed pubertal growth
Synonym: Delayed puberty (& [NOS])
Tree Number: T3.12.15.6
database_cross_reference: CCPSS:1003377
database_cross_reference: CHV:0000010359
database_cross_reference: CSP:2586-8835
database_cross_reference: DO:DOID:5575
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U003541
database_cross_reference: HPO:HP:0000823
database_cross_reference: ICD10:E30.0
database_cross_reference: ICD10AM:E30.0
database_cross_reference: ICD10CM:E30.0
database_cross_reference: ICPC2P:T99047
database_cross_reference: MDR:10012205
database_cross_reference: MEDCIN:37614
database_cross_reference: MSH:D011628
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:259.0
database_cross_reference: NCI:C62587
database_cross_reference: NCI_CTCAE:E10308
database_cross_reference: NCI_NICHD:C62587
database_cross_reference: NDFRT:N0000002534
database_cross_reference: OMIM:MTHU036721
database_cross_reference: OMIM:MTHU037333
database_cross_reference: RCD:X40O7
database_cross_reference: SNM:F-96120
database_cross_reference: SNMI:DB-00120
database_cross_reference: SNOMEDCT_US:123526007
database_cross_reference: SNOMEDCT_US:154715005
database_cross_reference: SNOMEDCT_US:267487003
database_cross_reference: SNOMEDCT_US:39760001
database_cross_reference: SNOMEDCT_US:400003000
database_cross_reference: SNOMEDCT_VET:123526007

Growth hormone deficiency
type: Class
subclass of: Abnormality of circulating hormone level
definition: Insufficient production of growth hormone, which is produced by the anterior pituitary gland. Growth hormone is a major participant in control of growth and metabolism.
PMOID: PMO:00006195
Subclass_of: Abnormality of circulating hormone level
Synonym: GHD
Synonym: GHD - Growth hormon deficiency
Synonym: GHD - Growth hormone deficiency
Synonym: Growth hormone deficiency (disorder)
Synonym: Growth hormone deficiency, NOS
Synonym: Growth hormone insufficiency
Synonym: STH deficiency
Synonym: Somatotropin Deficiency
Synonym: Somatotropin deficiency
Synonym: Somatotropin deficiency (disorder)
Tree Number: T3.12.3.22
database_cross_reference: CHV:0000026643
database_cross_reference: CSP:2715-1517
database_cross_reference: MDR:10056438
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C102986
database_cross_reference: NCI_NICHD:C102986
database_cross_reference: OMIM:MTHU004822
database_cross_reference: RCD:Xa9Ap
database_cross_reference: SNMI:DB-12500
database_cross_reference: SNOMEDCT_US:154702001
database_cross_reference: SNOMEDCT_US:302867007
database_cross_reference: SNOMEDCT_US:397827003
database_cross_reference: SNOMEDCT_US:44008002

Abnormality of the parathyroid gland
type: Class
subclass of: Abnormality of the endocrine system
definition: An abnormality of the parathyroid gland.
PMOID: PMO:00006255
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.7
database_cross_reference: HPO:HP:0000828

Insulin-resistant diabetes mellitus
type: Class
subclass of: Diabetes mellitus
definition: A type of diabetes mellitus related not to lack of insulin but rather to lack of response to insulin on the part of the target tissues of insulin such as muscle, fat, and liver cells. This type of diabetes is typically associated with increases both in blood glucose concentrations as will as in fasting and postprandial serum insulin levels.
PMOID: PMO:00006364
Subclass_of: Diabetes mellitus
Synonym: DIABETES MELLITUS NOS INSULIN RESISTANT
Synonym: DIABETES MELLITUS, INSULIN-RESISTANT
Synonym: Diabetes mellitus, insulin-resistant
Synonym: Insulin resistant diabetes
Synonym: Insulin resistant diabetes mellitus
Synonym: Insulin-resistant diabetes
Synonym: diabetes insulin resistant
Synonym: diabetes resistant insulin
Synonym: insulin resistant diabetes
Synonym: insulin resistant diabetes (mellitus)
Tree Number: T3.12.13.2
database_cross_reference: CCPSS:0026066
database_cross_reference: CHV:0000050224
database_cross_reference: HPO:HP:0000831
database_cross_reference: ICD10CM:E11
database_cross_reference: MDR:10022491
database_cross_reference: OMIM:147670
database_cross_reference: OMIM:MTHU002022
database_cross_reference: OMIM:MTHU009476
database_cross_reference: OMIM:MTHU009666
database_cross_reference: OMIM:MTHU010099
database_cross_reference: OMIM:MTHU034767

Abnormality of the adrenal glands
type: Class
subclass of: Abnormality of the endocrine system
definition: Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kindneys.
PMOID: PMO:00006206
Subclass_of: Abnormality of the endocrine system
Synonym: Adrenal abnormalities
Tree Number: T3.12.5
database_cross_reference: HPO:HP:0000834

Adrenogenital syndrome
type: Class
subclass of: Puberty and gonadal disorders
definition: Adrenogenital syndrome is also known as congenital adrenal hyperplasia, which results from disorders of steroid hormone production in the adrenal glands leading to a deficiency of cortisol. The pituitary gland reacts by increased secretion of corticotropin, which in turn causes the adrenal glands to overproduce certain intermediary hormones which have testosterone-like effects.
PMOID: PMO:00006400
Subclass_of: Puberty and gonadal disorders
Synonym: ADRENAL HYPERPLASIA CONGEN
Synonym: ADRENAL HYPERPLASIA CONGENITAL
Synonym: ADRENAL HYPERPLASIA, CONGENITAL
Synonym: Adrenal Hyperplasia
Synonym: Adrenal Hyperplasia, Congenital
Synonym: Adrenal Hyperplasia, Congenital [Disease/Finding]
Synonym: Adrenal Hyperplasias, Congenital
Synonym: Adrenal hyperplasia syndrome, congenital
Synonym: Adrenogenital Disorder
Synonym: Adrenogenital Syndrome
Tree Number: T3.12.15.4
database_cross_reference: CCPSS:0043598
database_cross_reference: CHV:0000000769
database_cross_reference: CSP:0060-3730
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0008258
database_cross_reference: ICD10CM:E25.0
database_cross_reference: LNC:LP56767-4
database_cross_reference: LNC:MTHU021596
database_cross_reference: MDR:10010323
database_cross_reference: MEDCIN:30433
database_cross_reference: MEDLINEPLUS:128
database_cross_reference: MSH:D000312
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:255.2
database_cross_reference: NCI:C34360
database_cross_reference: NCI_NICHD:C34360
database_cross_reference: NDFRT:N0000000328
database_cross_reference: OMIM:MTHU014663
database_cross_reference: RCD:X40MT
database_cross_reference: SNM:D-2306
database_cross_reference: SNMI:D6-80100
database_cross_reference: SNOMEDCT_US:190511001
database_cross_reference: SNOMEDCT_US:237751000
database_cross_reference: SNOMEDCT_US:27037004

Hyperactive renin-angiotensin system
type: Class
subclass of: Abnormality of renin-angiotensin system
definition: An abnormally increased activity of the renin-angiotensin system, causing hypertension by a combination of volume excess and vasoconstrictor mechanisms.
PMOID: PMO:00006205
Subclass_of: Abnormality of renin-angiotensin system
Tree Number: T3.12.4.3
database_cross_reference: HPO:HP:0000841

Abnormality of renin-angiotensin system
type: Class
subclass of: Abnormality of the endocrine system
definition: An abnormality of the renin-angiotensin system.
PMOID: PMO:00006200
Subclass_of: Abnormality of the endocrine system
Synonym: Abnormality of the renin-aldosterone axis
Tree Number: T3.12.4
database_cross_reference: HPO:HP:0000847

Menstrual irregularities
type: Class
subclass of: Puberty and gonadal disorders
PMOID: PMO:00006416
Subclass_of: Puberty and gonadal disorders
Synonym: Menstrual irregularity
Tree Number: T3.12.15.9
database_cross_reference: HPO:HP:0000858

Central diabetes insipidus
type: Class
subclass of: Diabetes insipidus
definition: A form of diabetes insipidus related to a failure of vasopressin (AVP) release from the hypothalamus.
PMOID: PMO:00006360
Subclass_of: Diabetes insipidus
Synonym: Antidiuretic hormone deficiency
Synonym: CDI
Synonym: Central Diabetes Insipidus
Synonym: Central diabetes insipidus (disorder)
Synonym: Central diabetes insipidus [Ambiguous]
Synonym: Cranial diabetes insipidus
Synonym: DIABETES INSIPIDUS, CRANIAL TYPE
Synonym: DIABETES INSIPIDUS, NEUROHYPOPHYSEAL
Synonym: DIABETES INSIPIDUS, NEUROHYPOPHYSEAL TYPE
Synonym: DIABETES INSIPIDUS, PRIMARY CENTRAL
Tree Number: T3.12.12.1
database_cross_reference: CHV:0000044128
database_cross_reference: CSP:1849-2602
database_cross_reference: DO:DOID:12388
database_cross_reference: DXP:U000469
database_cross_reference: HPO:HP:0000863
database_cross_reference: MDR:10049518
database_cross_reference: MDR:10068587
database_cross_reference: MDR:10073192
database_cross_reference: MDR:10078568
database_cross_reference: MEDCIN:30492
database_cross_reference: MSH:D020790
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:253.5
database_cross_reference: NCI:C84933
database_cross_reference: NCI_NICHD:C84933
database_cross_reference: NDFRT:N0000004189
database_cross_reference: OMIM:125700
database_cross_reference: OMIM:192340
database_cross_reference: OMIM:304900
database_cross_reference: OMIM:MTHU004824
database_cross_reference: OMIM:MTHU054071
database_cross_reference: RCD:XE10Y
database_cross_reference: SNM:D-2103
database_cross_reference: SNMI:DB-13110
database_cross_reference: SNMI:DB-13144
database_cross_reference: SNOMEDCT_US:154699008
database_cross_reference: SNOMEDCT_US:15771004
database_cross_reference: SNOMEDCT_US:190484000
database_cross_reference: SNOMEDCT_US:267393007
database_cross_reference: SNOMEDCT_US:45369008
database_cross_reference: SNOMEDCT_US:64410003

Abnormality of the hypothalamus-pituitary axis
type: Class
subclass of: Abnormality of the endocrine system
definition: Abnormality of the pituitary gland (also known as hypophysis), which is an endocrine gland that protrudes from the bottom of the hypothalamus at the base of the brain. The pituitary gland secretes the hormones ACTH, TSH, PRL, GH, endorphins, FSH, LH, oxytocin, and antidiuretic hormone. The secretion of hormones from the anterior pituitary is under the strict control of hypothalamic hormones, and the posterior pituitary is essentially an extension of the hypothalamus, so that hypothalamus and pituitary gland may be regarded as a functional unit.
PMOID: PMO:00006250
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.6
database_cross_reference: HPO:HP:0000864

Diabetes insipidus
type: Class
subclass of: Abnormality of the endocrine system
definition: A state of excessive water intake and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus).
PMOID: PMO:00006359
Subclass_of: Abnormality of the endocrine system
Synonym: DI
Synonym: DI - Diabetes insipidus
Synonym: DIABETES INSIPIDUS
Synonym: Diabetes Insipidus
Synonym: Diabetes Insipidus [Disease/Finding]
Synonym: Diabetes insipidus (disorder)
Synonym: Diabetes insipidus, NOS
Synonym: diabete insipidus
Synonym: diabetes insipidus
Tree Number: T3.12.12
database_cross_reference: CCPSS:0056411
database_cross_reference: CHV:0000003833
database_cross_reference: CHV:0000044128
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-2602
database_cross_reference: CST:DIABETES INSIPID
database_cross_reference: DO:DOID:9409
database_cross_reference: DXP:U000959
database_cross_reference: HPO:HP:0000873
database_cross_reference: ICD10:E23.2
database_cross_reference: ICD10AM:E23.2
database_cross_reference: ICD10CM:E23.2
database_cross_reference: ICD9CM:253.5
database_cross_reference: ICPC2P:T99011
database_cross_reference: MDR:10012599
database_cross_reference: MEDLINEPLUS:3046
database_cross_reference: MSH:D003919
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C43263
database_cross_reference: NCI_NICHD:C43263
database_cross_reference: NDFRT:N0000000949
database_cross_reference: OMIM:MTHU013463
database_cross_reference: PSY:13960
database_cross_reference: RCD:XE10Y
database_cross_reference: SNM:D-2101
database_cross_reference: SNMI:DB-13100
database_cross_reference: SNOMEDCT_US:15771004
database_cross_reference: SNOMEDCT_US:190484000

Abnormality of the skeletal system
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the skeletal system.
PMOID: PMO:00011670
Subclass_of: Phenotypic Abnormality
Synonym: Skeletal abnormalities
Synonym: Skeletal anomalies
Tree Number: T3.20
database_cross_reference: HPO:HP:0000924

Abnormality of skeletal maturation
type: Class
subclass of: Abnormality of skeletal physiology
definition: The bones of the skeleton undergo a series of characteristic changes in size, shape, and calcification from fetal life until puberty. An abnormality of this process can include delayed or accelerated skeletal maturation, or deviation of some, but not all bones from the expected patterns of maturation.
PMOID: PMO:00013966
Subclass_of: Abnormality of skeletal physiology
Tree Number: T3.20.2.1
database_cross_reference: HPO:HP:0000927

Abnormality of the skull
type: Class
subclass of: Abnormality of the head
definition: An abnormality of the skull, the bony framework of the head which is comprised of eight cranial and fourteen facial bones.
PMOID: PMO:00002233
Subclass_of: Abnormality of the head
Synonym: Abnormality of the skull bones
Synonym: CRANIAL DEFORMITY
Synonym: Deformity of the skull
Synonym: MALFORMATION SKULL
Synonym: Malformation skull
Synonym: SKULL DEFORMITY
Synonym: Skull malformation
Synonym: Skull malformation NOS
Synonym: abnormalities skull
Synonym: cranial deformities
Tree Number: T3.4.1.4
database_cross_reference: CCPSS:0056624
database_cross_reference: CHV:0000023641
database_cross_reference: CSP:0725-7823
database_cross_reference: CST:ANOMALY CONGEN MS
database_cross_reference: DXP:U000890
database_cross_reference: HPO:HP:0000929
database_cross_reference: HPO:HP:0001363
database_cross_reference: MDR:10025530
database_cross_reference: MDR:10040963
database_cross_reference: MDR:10062348
database_cross_reference: MEDCIN:6387

Chondrocalcinosis
type: Class
subclass of: Ectopic calcification
definition: Radiographic evidence of articular calcification that represent calcium pyrophosphate depositions in soft tissue surrounding joints and at the insertions of tendons near joints (Entheses/Sharpey fibers) .
PMOID: PMO:00014002
Subclass_of: Ectopic calcification
Synonym: CHONDROCALCINOSIS
Synonym: CHONDROCALCINOSIS FAMILIARIS
Synonym: CHONDROCALCINOSIS, ARTICULAR
Synonym: CPDD
Synonym: CPDD - Calc pyroph deposit dis
Synonym: CPDD - Calcium pyrophosphate deposition disease
Synonym: CPPD - Calcium pyrophosphate deposition disease
Synonym: CPPD CRYSTAL DEPOSITION DISEASE
Synonym: CPPD-Calc pyroph depos disease
Synonym: Calc pyrophosph deposit dis
Tree Number: T3.20.4.3
database_cross_reference: AOD:0000005089
database_cross_reference: CCPSS:0032503
database_cross_reference: CHV:0000039124
database_cross_reference: COSTAR:U000134
database_cross_reference: CSP:1849-7902
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000744
database_cross_reference: HPO:HP:0000934
database_cross_reference: ICD10CM:M11.2
database_cross_reference: ICD9CM:712.2
database_cross_reference: ICD9CM:712.20
database_cross_reference: ICD9CM:712.3
database_cross_reference: ICPC2P:T99071
database_cross_reference: LCH:U000995
database_cross_reference: LCH_NW:sh85024677
database_cross_reference: MDR:10008688
database_cross_reference: MDR:10008689
database_cross_reference: MDR:10008690
database_cross_reference: MDR:10008691
database_cross_reference: MDR:10008720
database_cross_reference: MDR:10061761
database_cross_reference: MEDCIN:34403
database_cross_reference: MEDCIN:38257
database_cross_reference: MEDLINEPLUS:264
database_cross_reference: MSH:D002805
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:712.20
database_cross_reference: NDFRT:N0000000767
database_cross_reference: OMIM:MTHU005831
database_cross_reference: RCD:N021.
database_cross_reference: RCD:N021z
database_cross_reference: RCD:N022.
database_cross_reference: RCD:N0220
database_cross_reference: RCD:N022z
database_cross_reference: RCD:X702b
database_cross_reference: RCD:X702h
database_cross_reference: SNM:D-1183
database_cross_reference: SNMI:D6-34750
database_cross_reference: SNOMEDCT_US:156881000
database_cross_reference: SNOMEDCT_US:201624004
database_cross_reference: SNOMEDCT_US:201637001
database_cross_reference: SNOMEDCT_US:201648008
database_cross_reference: SNOMEDCT_US:201649000
database_cross_reference: SNOMEDCT_US:201650000
database_cross_reference: SNOMEDCT_US:201660009
database_cross_reference: SNOMEDCT_US:239832006
database_cross_reference: SNOMEDCT_US:239838005
database_cross_reference: SNOMEDCT_US:268142006
database_cross_reference: SNOMEDCT_US:60782007

Dysostosis multiplex
type: Class
subclass of: Abnormality of skeletal morphology
PMOID: PMO:00013953
Subclass_of: Abnormality of skeletal morphology
Synonym: Disease, Hurler's
Synonym: Disease;Hurlers
Synonym: Dysostosis multiplex (disorder)
Synonym: Dysostosis multiplex syndrome
Synonym: Ellis-Sheldon syndrome
Synonym: GARGOYLISM
Synonym: Gargoylism
Synonym: Gargoylism, Hurler Syndrome
Synonym: Gargoylisms
Synonym: HURLER
Tree Number: T3.20.1.11
database_cross_reference: CCPSS:0010694
database_cross_reference: CHV:0000016009
database_cross_reference: CHV:0000047707
database_cross_reference: CSP:1849-6334
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0000943
database_cross_reference: ICD10CM:E76.01
database_cross_reference: ICPC2P:T80001
database_cross_reference: JABL:463
database_cross_reference: MDR:10020470
database_cross_reference: MDR:10020471
database_cross_reference: MDR:10028048
database_cross_reference: MEDCIN:33580
database_cross_reference: MEDCIN:38229
database_cross_reference: MSH:D008059
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.5
database_cross_reference: NCI:C61261
database_cross_reference: OMIM:252800
database_cross_reference: OMIM:607014
database_cross_reference: OMIM:MTHU007185
database_cross_reference: RCD:X40Vy
database_cross_reference: RCD:X789y
database_cross_reference: SNM:D-3811
database_cross_reference: SNMI:D6-70110
database_cross_reference: SNMI:D6-70112
database_cross_reference: SNOMEDCT_US:190936000
database_cross_reference: SNOMEDCT_US:190938004
database_cross_reference: SNOMEDCT_US:254069004
database_cross_reference: SNOMEDCT_US:65327002
database_cross_reference: SNOMEDCT_US:75610003

Abnormality of the skin
type: Class
subclass of: Abnormality of the integument
definition: An abnormality of the skin.
PMOID: PMO:00008954
Subclass_of: Abnormality of the integument
Synonym: 4-40 CONGENITAL ANOMALIES OF THE SKIN
Synonym: ABNORM SKIN
Synonym: Abnormalities, Skin
Synonym: Abnormality, Skin
Synonym: CONGENITAL ANOMALIES OF THE SKIN
Synonym: Congen.integument anomalies
Synonym: Congenital Abnormality of the Skin
Synonym: Congenital Cutaneous Malformations
Synonym: Congenital Skin Disorder
Synonym: Congenital anomaly of integument, NOS
Tree Number: T3.16.3
database_cross_reference: CHV:0000011388
database_cross_reference: CSP:0726-8244
database_cross_reference: DO:DOID:609
database_cross_reference: HPO:HP:0000951
database_cross_reference: ICD10:Q82.9
database_cross_reference: ICD10AM:Q82.9
database_cross_reference: ICD10CM:Q82.9
database_cross_reference: ICPC2P:S83001
database_cross_reference: LCH_NW:sh87001845
database_cross_reference: MDR:10040888
database_cross_reference: MDR:10067769
database_cross_reference: MEDCIN:211334
database_cross_reference: MSH:D012868
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C97174
database_cross_reference: NCI_NICHD:C97174
database_cross_reference: NDFRT:N0000002759
database_cross_reference: RCD:PH...
database_cross_reference: RCD:XE1MX
database_cross_reference: SNM:M-25100
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-40000
database_cross_reference: SNMI:D4-40100
database_cross_reference: SNOMEDCT_US:199879009
database_cross_reference: SNOMEDCT_US:205541000
database_cross_reference: SNOMEDCT_US:205611009
database_cross_reference: SNOMEDCT_US:268292002
database_cross_reference: SNOMEDCT_US:5613003

Edema
type: Class
subclass of: Abnormality of fluid regulation
definition: An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
PMOID: PMO:00003978
Subclass_of: Abnormality of fluid regulation
Synonym: 363-364 EDEMAS
Synonym: Dropsy
Synonym: Dropsy, NOS
Synonym: EDEMA
Synonym: EDEMA (NOS)
Synonym: EDEMA NOS
Synonym: EDEMAS
Synonym: EDEMATOUS
Synonym: Edema (NOS)
Synonym: Edema (finding)
Tree Number: T3.6.13.2
database_cross_reference: AOD:0000005462
database_cross_reference: AOD:0000005836
database_cross_reference: BI:BI00114
database_cross_reference: CCPSS:1000739
database_cross_reference: CCPSS:1014846
database_cross_reference: CHV:0000004269
database_cross_reference: CHV:0000029664
database_cross_reference: COSTAR:273
database_cross_reference: CSP:0465-4760
database_cross_reference: CST:EDEMA
database_cross_reference: HPO:HP:0000969
database_cross_reference: ICD10:R60.9
database_cross_reference: ICD10AM:R60.9
database_cross_reference: ICD10AMAE:R60.9
database_cross_reference: ICD10CM:R60.9
database_cross_reference: ICD9CM:782.3
database_cross_reference: ICPC2P:K07003
database_cross_reference: LCH:U001504
database_cross_reference: LCH_NW:sh85040948
database_cross_reference: LNC:LA17263-7
database_cross_reference: LNC:LA19035-7
database_cross_reference: LNC:MTHU019803
database_cross_reference: MDR:10014210
database_cross_reference: MDR:10014211
database_cross_reference: MDR:10014234
database_cross_reference: MDR:10030095
database_cross_reference: MDR:10030114
database_cross_reference: MEDCIN:278545
database_cross_reference: MEDCIN:7268
database_cross_reference: MEDLINEPLUS:1229
database_cross_reference: MSH:D004487
database_cross_reference: MTH:715
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:782.3
database_cross_reference: NCI:C3002
database_cross_reference: NCI_CDISC:C3002
database_cross_reference: NCI_FDA:1820
database_cross_reference: NCI_NCI-GLOSS:CDR0000045676
database_cross_reference: NCI_NICHD:C3002
database_cross_reference: NDFRT:N0000001057
database_cross_reference: OMIM:MTHU000002
database_cross_reference: OMIM:MTHU007987
database_cross_reference: RCD:183Z.
database_cross_reference: RCD:R023.
database_cross_reference: RCD:R0232
database_cross_reference: RCD:R023z
database_cross_reference: RCD:X78zV
database_cross_reference: RCD:XE0qw
database_cross_reference: RCDAE:183Z.
database_cross_reference: RCDAE:R023.
database_cross_reference: RCDAE:R023z
database_cross_reference: RCDAE:X78zV
database_cross_reference: RCDAE:XE0qw
database_cross_reference: RCDSY:R023.
database_cross_reference: RCDSY:R0232
database_cross_reference: RCDSY:R023z
database_cross_reference: SNM:M-36500
database_cross_reference: SNM:U000308
database_cross_reference: SNMI:M-36010
database_cross_reference: SNMI:M-36300
database_cross_reference: SNOMEDCT_US:139241006
database_cross_reference: SNOMEDCT_US:139250008
database_cross_reference: SNOMEDCT_US:155375008
database_cross_reference: SNOMEDCT_US:158241008

Anhidrosis
type: Class
subclass of: Abnormality of skin adnexa physiology
definition: Inability to sweat.
PMOID: PMO:00008944
Subclass_of: Abnormality of skin adnexa physiology
Synonym: ANHIDROSIS
Synonym: ANHYDROSIS
Synonym: Absence of sweating
Synonym: Absence of sweating (finding)
Synonym: Absent sweating
Synonym: Adiaphoresis
Synonym: Anhidrosis (disorder)
Synonym: Anhydrosis
Synonym: Lack of sweating
Synonym: SWEATING ABSENCE
Tree Number: T3.16.2.1
database_cross_reference: CHV:0000001189
database_cross_reference: CST:SWEAT DEC
database_cross_reference: DO:DOID:11156
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000119
database_cross_reference: DXP:U003898
database_cross_reference: HPO:HP:0000970
database_cross_reference: ICD10:L74.4
database_cross_reference: ICD10AM:L74.4
database_cross_reference: ICD10CM:L74.4
database_cross_reference: ICD9CM:705.0
database_cross_reference: LCH_NW:sh85005149
database_cross_reference: MDR:10002512
database_cross_reference: MDR:10002513
database_cross_reference: MEDCIN:310758
database_cross_reference: MEDCIN:6118
database_cross_reference: MSH:D007007
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34385
database_cross_reference: OMIM:MTHU001816
database_cross_reference: RCD:X76A2
database_cross_reference: RCD:XE1BK
database_cross_reference: SNM:F-03305
database_cross_reference: SNMI:D0-52010
database_cross_reference: SNMI:F-42205
database_cross_reference: SNOMEDCT_US:14662005
database_cross_reference: SNOMEDCT_US:156414006
database_cross_reference: SNOMEDCT_US:201189007
database_cross_reference: SNOMEDCT_US:39659002
database_cross_reference: SNOMEDCT_VET:39659002

Abnormality of the sweat gland
type: Class
subclass of: Abnormality of skin adnexa morphology
definition: An abnormality of the sweat gland.
PMOID: PMO:00008922
Subclass_of: Abnormality of skin adnexa morphology
Tree Number: T3.16.1.3

Abnormality of subcutaneous fat tissue
type: Class
subclass of: Abnormal adipose tissue morphology
PMOID: PMO:00001265
Subclass_of: Abnormal adipose tissue morphology
Synonym: Abnormality of fatty tissue below the skin
Tree Number: T3.3.1.2
database_cross_reference: HPO:HP:0001001

Abnormality of the hand
type: Class
subclass of: Abnormality of the upper limb
definition: An abnormality affecting one or both hands.
PMOID: PMO:00002869
Subclass_of: Abnormality of the upper limb
Synonym: Abnormal hands
Synonym: Deformities, Hand
Synonym: Deformity of hand
Synonym: Deformity of hand (finding)
Synonym: Deformity, Hand
Synonym: HAND DEFORMITY
Synonym: Hand Deformities
Synonym: Hand Deformities [Disease/Finding]
Synonym: Hand Deformity
Synonym: Hand anomalies
Tree Number: T3.5.4.3
database_cross_reference: CCPSS:0058855
database_cross_reference: CHV:0000005790
database_cross_reference: HPO:HP:0001155
database_cross_reference: LCH_NW:sh85058616
database_cross_reference: MDR:10025526
database_cross_reference: MDR:10025527
database_cross_reference: MDR:10025529
database_cross_reference: MDR:10050557
database_cross_reference: MDR:10061194
database_cross_reference: MEDCIN:10207
database_cross_reference: MEDCIN:63220
database_cross_reference: MSH:D006226
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001407
database_cross_reference: OMIM:MTHU004517
database_cross_reference: OMIM:MTHU006016
database_cross_reference: RCD:Xa767
database_cross_reference: SNOMEDCT_US:299033004

Abnormalities of placenta or umbilical cord
type: Class
subclass of: Abnormality of prenatal development or birth
definition: An abnormality of the placenta (the organ that connects the developing fetus to the uterine wall) or of the umbilical cord (the cord that connects the fetus to the placenta).
PMOID: PMO:00004313
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.2
database_cross_reference: HPO:HP:0001194

Single umbilical artery
type: Class
subclass of: Abnormality of the fetal cardiovascular system
definition: Single umbilical artery (SUA) is the absence of one of the two umbilical arteries surrounding the fetal bladder and in the fetal umbilical cord.
PMOID: PMO:00004969
Subclass_of: Abnormality of the fetal cardiovascular system
Synonym: Congenital absence of umbilical artery
Synonym: Single Umbilical Arteries
Synonym: Single Umbilical Artery
Synonym: Single Umbilical Artery [Disease/Finding]
Synonym: Single artery AND vein of umbilical cord
Synonym: Single umbilical artery (disorder)
Synonym: Single umbilical artery -RETIRED-
Synonym: Two Vessel Cord
Synonym: Two Vessel Cords
Synonym: Two vessel cord
Tree Number: T3.9.4.7
database_cross_reference: CHV:0000026096
database_cross_reference: HPO:HP:0001195
database_cross_reference: ICD10CM:Q27.0
database_cross_reference: MDR:10049807
database_cross_reference: MEDCIN:297999
database_cross_reference: MEDCIN:355333
database_cross_reference: MSH:D058529
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:747.5
database_cross_reference: NCI:C117359
database_cross_reference: NCI_NICHD:C117359
database_cross_reference: NDFRT:N0000182214
database_cross_reference: OMIM:MTHU037190
database_cross_reference: OMIM:MTHU037229
database_cross_reference: OMIM:MTHU039171
database_cross_reference: RCD:P752.
database_cross_reference: SNMI:D4-F5045
database_cross_reference: SNOMEDCT_US:123277001
database_cross_reference: SNOMEDCT_US:204470001
database_cross_reference: SNOMEDCT_US:63070006

Abnormality of prenatal development or birth
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities.
PMOID: PMO:00004292
Subclass_of: Phenotypic Abnormality
Tree Number: T3.7
database_cross_reference: HPO:HP:0001197

Autoamputation
type: Class
subclass of: Abnormality of limbs
definition: Spontaneous detachment (amputation) of an appendage from the body.
PMOID: PMO:00003467
Subclass_of: Abnormality of limbs
Tree Number: T3.5.6
database_cross_reference: HPO:HP:0001218

Seizures
type: Class
subclass of: Abnormality of nervous system physiology
definition: Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures.
PMOID: PMO:00011263
Subclass_of: Abnormality of nervous system physiology
Synonym: A70-A72 CONVULSIONS
Synonym: CONVULSION
Synonym: CONVULSION (NOS)
Synonym: CONVULSIONS
Synonym: Convulsion
Synonym: Convulsion (NOS)
Synonym: Convulsion (disorder)
Synonym: Convulsion NOS
Synonym: Convulsion, NOS
Synonym: Convulsions
Tree Number: T3.18.3.22
database_cross_reference: AOD:0000004417
database_cross_reference: BI:BI00559
database_cross_reference: CCPSS:1017690
database_cross_reference: CHV:0000003335
database_cross_reference: CHV:0000011162
database_cross_reference: COSTAR:672
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0485-6986
database_cross_reference: CSP:2057-3348
database_cross_reference: CST:CONVULS
database_cross_reference: DXP:U003487
database_cross_reference: HPO:HP:0001250
database_cross_reference: ICD10CM:R56.9
database_cross_reference: ICD9CM:780.3
database_cross_reference: ICPC2P:N07001
database_cross_reference: ICPC2P:N07002
database_cross_reference: ICPC2P:N07003
database_cross_reference: LCH:U001154
database_cross_reference: LNC:LA15899-0
database_cross_reference: LNC:LA7472-9
database_cross_reference: MDR:10010904
database_cross_reference: MDR:10010906
database_cross_reference: MDR:10010914
database_cross_reference: MDR:10010922
database_cross_reference: MDR:10016731
database_cross_reference: MDR:10016735
database_cross_reference: MDR:10016736
database_cross_reference: MDR:10039906
database_cross_reference: MDR:10039910
database_cross_reference: MEDCIN:658
database_cross_reference: MEDCIN:66036
database_cross_reference: MEDLINEPLUS:396
database_cross_reference: MSH:D012640
database_cross_reference: MTH:673
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.39
database_cross_reference: NCI:C2962
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CTCAE:E12804
database_cross_reference: NCI_FDA:2063
database_cross_reference: NCI_NCI-GLOSS:CDR0000045484
database_cross_reference: NCI_NICHD:C2962
database_cross_reference: NDFRT:N0000002713
database_cross_reference: OMIM:MTHU000242
database_cross_reference: OMIM:MTHU004223
database_cross_reference: PDQ:CDR0000525976
database_cross_reference: PSY:11750
database_cross_reference: PSY:46145
database_cross_reference: RCD:R003.
database_cross_reference: RCD:R0032
database_cross_reference: RCD:R003z
database_cross_reference: RCD:XaDbE
database_cross_reference: RCD:XaEHz
database_cross_reference: RCD:XaEI2
database_cross_reference: RCDSY:R003.
database_cross_reference: RCDSY:R0032
database_cross_reference: RCDSY:R003z
database_cross_reference: SNM:F-87000
database_cross_reference: SNM:U000217
database_cross_reference: SNMI:F-A7000
database_cross_reference: SNMI:F-A7100
database_cross_reference: SNOMEDCT_US:158138006
database_cross_reference: SNOMEDCT_US:158141002
database_cross_reference: SNOMEDCT_US:158142009

Syncope
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow.
PMOID: PMO:00004958
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: A faint
Synonym: Attack(s);fainting
Synonym: COLLAPSE FLEETING
Synonym: COLLAPSE TRANSIENT
Synonym: Collapse [D]
Synonym: Collapse fleeting
Synonym: Collapse transient
Synonym: FAINT
Synonym: FAINTING
Synonym: FAINTING EPISODES
Tree Number: T3.9.3.15
database_cross_reference: AOD:0000004427
database_cross_reference: AOD:0000022991
database_cross_reference: BI:BI00562
database_cross_reference: CCPSS:1004859
database_cross_reference: CCPSS:1018236
database_cross_reference: CHV:0000011975
database_cross_reference: CHV:0000037419
database_cross_reference: COSTAR:716
database_cross_reference: COSTAR:U000277
database_cross_reference: CSP:2056-8027
database_cross_reference: CST:DIZZINESS
database_cross_reference: CST:SYNCOPE
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U003903
database_cross_reference: HPO:HP:0001279
database_cross_reference: ICD10:R55
database_cross_reference: ICD10AM:R55
database_cross_reference: ICD10CM:R55
database_cross_reference: ICD9CM:780.2
database_cross_reference: ICPC2EENG:A06
database_cross_reference: ICPC2P:A06003
database_cross_reference: ICPC2P:A06005
database_cross_reference: ICPC2P:A06009
database_cross_reference: ICPC2P:A06012
database_cross_reference: LNC:LA16987-2
database_cross_reference: LNC:MTHU020851
database_cross_reference: MDR:10009911
database_cross_reference: MDR:10009916
database_cross_reference: MDR:10016167
database_cross_reference: MDR:10016169
database_cross_reference: MDR:10016170
database_cross_reference: MDR:10016179
database_cross_reference: MDR:10034100
database_cross_reference: MDR:10042729
database_cross_reference: MDR:10042771
database_cross_reference: MDR:10042772
database_cross_reference: MDR:10042773
database_cross_reference: MEDCIN:663
database_cross_reference: MEDLINEPLUS:1481
database_cross_reference: MSH:D013575
database_cross_reference: MTH:U003368
database_cross_reference: MTHICD9:780.2
database_cross_reference: NCI:C35053
database_cross_reference: NCI:C50857
database_cross_reference: NCI_CTCAE:E12832
database_cross_reference: NCI_FDA:1610
database_cross_reference: NCI_FDA:1847
database_cross_reference: NCI_NICHD:C35053
database_cross_reference: NDFRT:N0000002873
database_cross_reference: OMIM:MTHU005009
database_cross_reference: OMIM:MTHU046179
database_cross_reference: PSY:19110
database_cross_reference: PSY:51160
database_cross_reference: RCD:R002.
database_cross_reference: RCD:R0021
database_cross_reference: RCD:R002z
database_cross_reference: RCD:XM010
database_cross_reference: RCD:XM06a
database_cross_reference: RCD:XM0CY
database_cross_reference: RCD:XaBua
database_cross_reference: RCDSY:R002.
database_cross_reference: RCDSY:R0021
database_cross_reference: RCDSY:R002z
database_cross_reference: SNM:F-85580

Tetany
type: Class
subclass of: Abnormality of muscle physiology
definition: A condition characterized by intermittent involuntary contraction of muscles (spasms) related to hypocalcemia or occasionally magneisum deficiency.
PMOID: PMO:00009670
Subclass_of: Abnormality of muscle physiology
Synonym: TETANY
Synonym: Tetanies
Synonym: Tetany (disorder)
Synonym: Tetany (finding)
Synonym: Tetany NOS
Synonym: Tetany [Ambiguous]
Synonym: Tetany [Disease/Finding]
Synonym: Tetany, NOS
Synonym: [D]Tetany
Synonym: [D]Tetany (context-dependent category)
Tree Number: T3.17.3.10
database_cross_reference: AOD:0000005049
database_cross_reference: CHV:0000012127
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3848
database_cross_reference: CST:TETANY
database_cross_reference: HPO:HP:0001281
database_cross_reference: ICD10:R29.0
database_cross_reference: ICD10AM:R29.0
database_cross_reference: ICD10CM:R29.0
database_cross_reference: ICD9CM:781.7
database_cross_reference: LCH:U004625
database_cross_reference: LCH_NW:sh85134169
database_cross_reference: MDR:10043380
database_cross_reference: MEDCIN:729
database_cross_reference: MEDCIN:9008
database_cross_reference: MSH:D013746
database_cross_reference: MTH:U000234
database_cross_reference: NCI:C114789
database_cross_reference: NCI_NICHD:C114789
database_cross_reference: NDFRT:N0000002916
database_cross_reference: OMIM:MTHU037171
database_cross_reference: RCD:R017.
database_cross_reference: RCD:R017z
database_cross_reference: RCD:XM078
database_cross_reference: RCDSY:R017.
database_cross_reference: RCDSY:R017z
database_cross_reference: SNM:F-81420
database_cross_reference: SNMI:F-11370
database_cross_reference: SNOMEDCT_US:10629009
database_cross_reference: SNOMEDCT_US:154697005
database_cross_reference: SNOMEDCT_US:158212004
database_cross_reference: SNOMEDCT_US:158214003
database_cross_reference: SNOMEDCT_US:206837000
database_cross_reference: SNOMEDCT_US:206839002
database_cross_reference: SNOMEDCT_US:267479004
database_cross_reference: SNOMEDCT_US:271802009

Bulbar palsy
type: Class
subclass of: Abnormality of nervous system physiology
definition: Bulbar weakness (or bulbar palsy) refers to bilateral impairment of function of the lower cranial nerves IX, X, XI and XII, which occurs due to lower motor neuron lesion either at nuclear or fascicular level in the medulla or from bilateral lesions of the lower cranial nerves outside the brain-stem. Bulbar weakness is often associated with difficulty in chewing, weakness of the facial muscles, dysarthria, palatal weakness and regurgitation of fluids, dysphagia, and dysphonia.
PMOID: PMO:00011190
Subclass_of: Abnormality of nervous system physiology
Synonym: Bulbar Palsies, Progressive
Synonym: Bulbar Palsy, Progressive
Synonym: Bulbar Palsy, Progressive [Disease/Finding]
Synonym: Bulbar paralysis
Synonym: PBP - Progressive bulbar palsy
Synonym: Palsies, Progressive Bulbar
Synonym: Palsy, Progressive Bulbar
Synonym: Progressive Bulbar Palsies
Synonym: Progressive Bulbar Palsy
Synonym: Progressive bulbar palsy
Tree Number: T3.18.3.12
database_cross_reference: CHV:0000009270
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3603
database_cross_reference: DO:DOID:681
database_cross_reference: ICD10CM:G12.22
database_cross_reference: ICD9CM:335.22
database_cross_reference: MDR:10036800
database_cross_reference: MEDCIN:36392
database_cross_reference: MSH:D010244
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85026
database_cross_reference: NDFRT:N0000002304
database_cross_reference: RCD:F1522
database_cross_reference: SNM:D-8143
database_cross_reference: SNMI:DA-23030
database_cross_reference: SNOMEDCT_US:54304004

Encephalopathy
type: Class
subclass of: Abnormality of nervous system physiology
definition: Encephalopathy is a term that means brain disease, damage, or malfunction. In general, encephalopathy is manifested by an altered mental state.
PMOID: PMO:00011198
Subclass_of: Abnormality of nervous system physiology
Synonym: BRAIN DIS
Synonym: BRAIN DISORDER (NOS)
Synonym: Brain
Synonym: Brain Disease
Synonym: Brain Diseases
Synonym: Brain Diseases [Disease/Finding]
Synonym: Brain Disorder
Synonym: Brain Disorders
Synonym: Brain condition NOS
Synonym: Brain conditions NOS
Tree Number: T3.18.3.17
database_cross_reference: CHV:0000002134
database_cross_reference: CHV:0000032204
database_cross_reference: CSP:0485-0499
database_cross_reference: CST:BRAIN SYND ACUTE
database_cross_reference: CST:NER/CNS/B
database_cross_reference: DO:DOID:936
database_cross_reference: ICD10:G93.9
database_cross_reference: ICD10AM:G93.9
database_cross_reference: ICD10CM:G93.9
database_cross_reference: ICD9CM:348.9
database_cross_reference: LCH_NW:sh85016332
database_cross_reference: MDR:10006119
database_cross_reference: MDR:10006120
database_cross_reference: MDR:10045690
database_cross_reference: MEDCIN:210110
database_cross_reference: MEDCIN:337652
database_cross_reference: MEDLINEPLUS:174
database_cross_reference: MSH:D001927
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C96413
database_cross_reference: NCI_NICHD:C96413
database_cross_reference: NDFRT:N0000000605
database_cross_reference: PSY:06800
database_cross_reference: RCD:F28z.
database_cross_reference: SNMI:DA-00010
database_cross_reference: SNOMEDCT_US:193059005
database_cross_reference: SNOMEDCT_US:81308009

Abnormal nervous system electrophysiology
type: Class
subclass of: Abnormality of nervous system physiology
definition: An abnormality of the function of the electrical signals with which nerve cells communicate with each other or with muscles as measured by electrophysiological investigations.
PMOID: PMO:00010578
Subclass_of: Abnormality of nervous system physiology
Synonym: Neurophysiologic abnormalities
Synonym: Neurophysiologic abnormality
Tree Number: T3.18.3.4
database_cross_reference: HPO:HP:0001311

Muscle weakness
type: Class
subclass of: Abnormality of muscle physiology
definition: Reduced strength of muscles.
PMOID: PMO:00009627
Subclass_of: Abnormality of muscle physiology
Synonym: Incomplete paralysis
Synonym: Muscle Pareses
Synonym: Muscle Paresis
Synonym: Muscular Pareses
Synonym: Muscular Paresis
Synonym: PARALYSIS PARTIAL
Synonym: PARESIS
Synonym: Pareses
Synonym: Pareses, Muscle
Synonym: Pareses, Muscular
Tree Number: T3.17.3.8
database_cross_reference: CCPSS:0009933
database_cross_reference: CCPSS:0024112
database_cross_reference: CHV:0000009312
database_cross_reference: CHV:0000047949
database_cross_reference: COSTAR:U000509
database_cross_reference: CST:PARALYSIS
database_cross_reference: ICPC2P:N18006
database_cross_reference: MDR:10033985
database_cross_reference: MSH:D010291
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C50688
database_cross_reference: NCI_FDA:1998
database_cross_reference: NDFRT:N0000002325
database_cross_reference: RCD:XM03n
database_cross_reference: SNM:F-80850
database_cross_reference: SNMI:F-A0850
database_cross_reference: SNOMEDCT_US:26544005

Abnormal joint morphology
type: Class
subclass of: Abnormality of skeletal morphology
definition: An abnormal structure or form of the joints, i.e., one or more of the articulations where two bones join.
PMOID: PMO:00013815
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.5

Flexion contracture
type: Class
subclass of: Abnormality of connective tissue
definition: A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints.
PMOID: PMO:00001311
Subclass_of: Abnormality of connective tissue
Synonym: CONTRACTURE FLEXION
Synonym: Flexion contracture (disorder)
Synonym: Flexion contracture (qualifier value)
Synonym: Flexion contractures
Synonym: Flexion deformity
Synonym: Flexion deformity (disorder)
Synonym: Flexion deformity (morphologic abnormality)
Synonym: Flexion deformity, site unspecified
Synonym: Flexion deformity, unspecified site
Synonym: contracture flexion
Tree Number: T3.3.6
database_cross_reference: CCPSS:0016619
database_cross_reference: CHV:0000029608
database_cross_reference: CHV:0000056873
database_cross_reference: HPO:HP:0001371
database_cross_reference: ICD10:M21.2
database_cross_reference: ICD10AM:M21.2
database_cross_reference: ICD10AM:M21.29
database_cross_reference: ICD10CM:M21.2
database_cross_reference: ICD10CM:M21.20
database_cross_reference: MEDCIN:335775
database_cross_reference: OMIM:MTHU003721
database_cross_reference: RCD:N369.
database_cross_reference: RCD:XC0cz
database_cross_reference: SNM:M-31080
database_cross_reference: SNMI:M-31710
database_cross_reference: SNOMEDCT_US:156547000
database_cross_reference: SNOMEDCT_US:203598005
database_cross_reference: SNOMEDCT_US:264526003
database_cross_reference: SNOMEDCT_US:268064000
database_cross_reference: SNOMEDCT_US:385522000
database_cross_reference: SNOMEDCT_US:88565003

Abnormality of the liver
type: Class
subclass of: Abnormality of the abdominal organs
definition: An abnormality of the liver.
PMOID: PMO:00005375
Subclass_of: Abnormality of the abdominal organs
Synonym: Liver abnormality
Tree Number: T3.10.4.2
database_cross_reference: HPO:HP:0001392

Abnormality of the musculature of the lower limbs
type: Class
subclass of: Abnormality of the lower limb
PMOID: PMO:00002803
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.5
database_cross_reference: HPO:HP:0001437

Abnormality of abdomen morphology
type: Class
subclass of: Abnormality of the digestive system
definition: A structural abnormality of the abdomen ('belly'), that is, the part of the body between the pelvis and the thorax.
PMOID: PMO:00005300
Subclass_of: Abnormality of the digestive system
Tree Number: T3.10.1

Abnormality of the gluteal musculature
type: Class
subclass of: Abnormality of the musculature of the pelvis
PMOID: PMO:00009731
Subclass_of: Abnormality of the musculature of the pelvis
Synonym: Abnormality of glutes
Tree Number: T3.17.10.1
database_cross_reference: HPO:HP:0001443

Abnormality of the hip-girdle musculature
type: Class
subclass of: Abnormality of the musculature of the pelvis
PMOID: PMO:00009732
Subclass_of: Abnormality of the musculature of the pelvis
Tree Number: T3.17.10.2
database_cross_reference: HPO:HP:0001445

Abnormality of the musculature of the upper limbs
type: Class
subclass of: Abnormality of the musculature of the limbs
PMOID: PMO:00002832
Subclass_of: Abnormality of the musculature of the limbs
Synonym: Abnormal upper limb muscles
Tree Number: T3.5.3.1
database_cross_reference: HPO:HP:0001446

Abnormality of the upper arm
type: Class
subclass of: Abnormality of the upper limb
PMOID: PMO:00003117
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.4
database_cross_reference: HPO:HP:0001454

Abnormality of the musculature of the pelvis
type: Class
subclass of: Abnormality of the musculature
PMOID: PMO:00009730
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.10
database_cross_reference: HPO:HP:0001469

Aplasia/Hypoplasia of the musculature of the pelvis
type: Class
subclass of: Abnormality of the musculature of the pelvis
PMOID: PMO:00009735
Subclass_of: Abnormality of the musculature of the pelvis
Synonym: Absent/small pelvis muscles
Synonym: Absent/underdeveloped pelvis muscles
Tree Number: T3.17.10.3
database_cross_reference: HPO:HP:0001471

Growth abnormality
type: Class
subclass of: Phenotypic Abnormality
PMOID: PMO:00014115
Subclass_of: Phenotypic Abnormality
Synonym: Abnormal growth
Synonym: Growth issue
Tree Number: T3.24
database_cross_reference: HPO:HP:0001507

Growth delay
type: Class
subclass of: Growth abnormality
definition: A deficiency or slowing down of growth pre- and postnatally.
PMOID: PMO:00014172
Subclass_of: Growth abnormality
Synonym: Delayed growth
Synonym: Delayed;growth
Synonym: Growth deficiency
Synonym: Growth delay (disorder)
Synonym: delay growth
Synonym: delayed disorder growth
Synonym: delayed growth
Synonym: delays growth
Synonym: growth delay
Tree Number: T3.24.4
database_cross_reference: CHV:0000036549
database_cross_reference: HPO:HP:0001510
database_cross_reference: ICPC2EENG:T10
database_cross_reference: ICPC2P:T10013
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU002219
database_cross_reference: OMIM:MTHU006431
database_cross_reference: OMIM:MTHU045544
database_cross_reference: RCD:Xa09f
database_cross_reference: SNOMEDCT_US:276617005

Intrauterine growth retardation
type: Class
subclass of: Growth delay
definition: An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.
PMOID: PMO:00014174
Subclass_of: Growth delay
Synonym: (Fetal growth retardation NOS) or (intrauterine growth retardation)
Synonym: (Fetal growth retardation NOS) or (intrauterine growth retardation) (disorder)
Synonym: FGR - Fetal growth retardation
Synonym: FGR - Foetal growth retardation
Synonym: Fet growth retard wtNOS
Synonym: Fetal Growth Retardation
Synonym: Fetal Growth Retardation [Disease/Finding]
Synonym: Fetal growth restriction
Synonym: Fetal growth retardation
Synonym: Fetal growth retardation (disorder)
Tree Number: T3.24.4.2
database_cross_reference: CCPSS:1013735
database_cross_reference: CHV:0000004992
database_cross_reference: CSP:2403-8925
database_cross_reference: HPO:HP:0001511
database_cross_reference: ICD10:P05.9
database_cross_reference: ICD10AM:P05.9
database_cross_reference: ICD9CM:764.9
database_cross_reference: ICD9CM:764.90
database_cross_reference: ICPC2P:W84015
database_cross_reference: LCH_NW:sh85047972
database_cross_reference: MDR:10016497
database_cross_reference: MDR:10016498
database_cross_reference: MDR:10016857
database_cross_reference: MDR:10022819
database_cross_reference: MDR:10048488
database_cross_reference: MDR:10048489
database_cross_reference: MDR:10054746
database_cross_reference: MDR:10055695
database_cross_reference: MDR:10055696
database_cross_reference: MDR:10070531
database_cross_reference: MDR:10070532
database_cross_reference: MDR:10071034
database_cross_reference: MEDCIN:35631
database_cross_reference: MSH:D005317
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:764.9
database_cross_reference: MTHICD9:764.90
database_cross_reference: NDFRT:N0000001235
database_cross_reference: OMIM:MTHU001305
database_cross_reference: OMIM:MTHU001437
database_cross_reference: OMIM:MTHU004084
database_cross_reference: OMIM:MTHU008018
database_cross_reference: OMIM:MTHU010681
database_cross_reference: OMIM:MTHU012015
database_cross_reference: OMIM:MTHU020425
database_cross_reference: OMIM:MTHU022021
database_cross_reference: OMIM:MTHU022541
database_cross_reference: OMIM:MTHU036654
database_cross_reference: OMIM:MTHU040979
database_cross_reference: RCD:X70Er
database_cross_reference: RCD:XE1eV
database_cross_reference: SNM:F-33710
database_cross_reference: SNMI:D8-70110
database_cross_reference: SNOMEDCT_US:156185006
database_cross_reference: SNOMEDCT_US:206166000
database_cross_reference: SNOMEDCT_US:22033007
database_cross_reference: SNOMEDCT_US:267337006
database_cross_reference: SNOMEDCT_US:268815007

Hemihypertrophy
type: Class
subclass of: Abnormality of limbs
definition: Overgrowth of only one side of the body.
PMOID: PMO:00003471
Subclass_of: Abnormality of limbs
Synonym: Asymmetric limb hypertrophy
Synonym: Congenital hemihypertrophy
Synonym: Congenital hemihypertrophy (disorder)
Synonym: Congenital hemihypertrophy (morphologic abnormality)
Synonym: HEMIHYPERTROPHY
Synonym: Hemi-hypertrophy
Synonym: Hemihyperplasia
Synonym: Hemihypertrophy, congenital
Synonym: congenital hemihypertrophy
Synonym: congenital hemihypertrophy (diagnosis)
Tree Number: T3.5.7
database_cross_reference: CHV:0000029578
database_cross_reference: CST:HYPERTROPHY
database_cross_reference: HPO:HP:0001528
database_cross_reference: MDR:10019463
database_cross_reference: MEDCIN:313612
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C88541
database_cross_reference: NCI_NCI-GLOSS:CDR0000482352
database_cross_reference: NCI_NICHD:C88541
database_cross_reference: OMIM:MTHU015904
database_cross_reference: OMIM:MTHU017558
database_cross_reference: RCD:PKyz6
database_cross_reference: SNM:M-20550
database_cross_reference: SNMI:M-20510
database_cross_reference: SNOMEDCT_US:205838004
database_cross_reference: SNOMEDCT_US:56007004

Ascites
type: Class
subclass of: Abnormality of abdomen morphology
definition: Accumulation of fluid in the peritoneal cavity.
PMOID: PMO:00005303
Subclass_of: Abnormality of abdomen morphology
Synonym: Accumulation of fluid in the abdomen
Tree Number: T3.10.1.3
database_cross_reference: HPO:HP:0001541

Abnormality of the umbilicus
type: Class
subclass of: Abnormality of the abdominal wall
definition: Abnormality of the umbilicus.
PMOID: PMO:00005555
Subclass_of: Abnormality of the abdominal wall
Synonym: Abnormal belly button
Synonym: Abnormal navel
Synonym: Abnormal umbilicus
Tree Number: T3.10.5.3
database_cross_reference: HPO:HP:0001551

Prenatal movement abnormality
type: Class
subclass of: Abnormality of prenatal development or birth
definition: An abnormality of fetal movement.
PMOID: PMO:00004410
Subclass_of: Abnormality of prenatal development or birth
Synonym: Abnormal intrauterine movements
Tree Number: T3.7.12
database_cross_reference: HPO:HP:0001557

Decreased fetal movement
type: Class
subclass of: Prenatal movement abnormality
definition: An abnormal reduction in quantity or strength of fetal movements.
PMOID: PMO:00004411
Subclass_of: Prenatal movement abnormality
Synonym: Baby kicking less
Synonym: Baby moving less
Synonym: Decreased fetal activity
Synonym: Decreased fetal movements
Synonym: Decreased fetal movements, unsp trimester, unsp
Synonym: Decreased fetal movements, unspecified trimester, not applicable or unspecified
Synonym: Decreased movement in utero
Synonym: Decreased;fetal movement
Synonym: Decreased;foetal movement
Synonym: FETAL ACTIVITY DECREASE
Tree Number: T3.7.12.1
database_cross_reference: CCPSS:0060630
database_cross_reference: CHV:0000023576
database_cross_reference: DXP:U001466
database_cross_reference: HPO:HP:0001558
database_cross_reference: ICD10CM:O36.81
database_cross_reference: ICD10CM:O36.8190
database_cross_reference: ICPC2P:W29011
database_cross_reference: MDR:10016866
database_cross_reference: MDR:10054744
database_cross_reference: MDR:10068449
database_cross_reference: MDR:10068461
database_cross_reference: MEDCIN:281778
database_cross_reference: MEDCIN:296351
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU009012
database_cross_reference: OMIM:MTHU037032
database_cross_reference: OMIM:MTHU037783
database_cross_reference: OMIM:MTHU037915
database_cross_reference: OMIM:MTHU038242
database_cross_reference: OMIM:MTHU051295
database_cross_reference: RCD:Xa04B
database_cross_reference: SNOMEDCT_US:199633001
database_cross_reference: SNOMEDCT_US:276369006

Abnormality of the amniotic fluid
type: Class
subclass of: Abnormality of prenatal development or birth
definition: Abnormality of the amniotic fluid, which is the fluid contained in the amniotic sac surrounding the developing fetus.
PMOID: PMO:00004346
Subclass_of: Abnormality of prenatal development or birth
Synonym: Abnormal amniotic fluid
Tree Number: T3.7.3
database_cross_reference: HPO:HP:0001560

Polyhydramnios
type: Class
subclass of: Abnormality of the amniotic fluid
definition: The presence of excess amniotic fluid in the uterus during pregnancy.
PMOID: PMO:00004350
Subclass_of: Abnormality of the amniotic fluid
Synonym: Excessive liquor
Synonym: HYDRAMNIOS
Synonym: Hydramnios
Synonym: Hydrops amnii
Synonym: Hydrops amnion
Synonym: Hydrops of amnion
Synonym: Hydrops of amnion (diagnosis)
Synonym: Hydrops of amnion (disorder)
Synonym: POLYHYDRAMNIOS
Synonym: Polyhydramnios &/or hydramnios
Tree Number: T3.7.3.4
database_cross_reference: CCPSS:0042417
database_cross_reference: CHV:0000006333
database_cross_reference: CST:PREGN DIS
database_cross_reference: DO:DOID:8488
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000860
database_cross_reference: DXP:U002004
database_cross_reference: HPO:HP:0001561
database_cross_reference: ICD10:O40
database_cross_reference: ICD10AM:O40
database_cross_reference: ICD10CM:O40
database_cross_reference: ICD9CM:657
database_cross_reference: ICD9CM:657.0
database_cross_reference: ICPC2P:W84016
database_cross_reference: MDR:10020486
database_cross_reference: MDR:10036079
database_cross_reference: MEDCIN:34306
database_cross_reference: MEDCIN:360742
database_cross_reference: MSH:D006831
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:657
database_cross_reference: NCI:C92848
database_cross_reference: NCI_CDISC:C92848
database_cross_reference: NCI_NICHD:C92848
database_cross_reference: NDFRT:N0000001561
database_cross_reference: OMIM:MTHU036439
database_cross_reference: OMIM:MTHU037881
database_cross_reference: RCD:L270.
database_cross_reference: RCD:L2700
database_cross_reference: RCD:L270z
database_cross_reference: RCD:XE0wt
database_cross_reference: SNM:M-29450
database_cross_reference: SNMI:D8-22100
database_cross_reference: SNOMEDCT_US:156188008
database_cross_reference: SNOMEDCT_US:157052008
database_cross_reference: SNOMEDCT_US:199644009
database_cross_reference: SNOMEDCT_US:199645005
database_cross_reference: SNOMEDCT_US:199648007
database_cross_reference: SNOMEDCT_US:199650004
database_cross_reference: SNOMEDCT_US:267261001
database_cross_reference: SNOMEDCT_US:405235009
database_cross_reference: SNOMEDCT_US:86203003
database_cross_reference: SNOMEDCT_VET:405235009
database_cross_reference: SNOMEDCT_VET:86203003

Oligohydramnios
type: Class
subclass of: Abnormality of the amniotic fluid
definition: Diminished amniotic fluid volume in pregnancy.
PMOID: PMO:00004349
Subclass_of: Abnormality of the amniotic fluid
Synonym: Deficient liquor
Synonym: OLIGOHYDRAMNIOS
Synonym: Oligohydramnios (disorder)
Synonym: Oligohydramnios - delivered
Synonym: Oligohydramnios NOS
Synonym: Oligohydramnios NOS (disorder)
Synonym: Oligohydramnios [Disease/Finding]
Synonym: Oligohydramnios unspecified
Synonym: Oligohydramnios unspecified (disorder)
Synonym: Oligohydramnios, NOS
Tree Number: T3.7.3.3
database_cross_reference: CCPSS:0043700
database_cross_reference: CHV:0000015263
database_cross_reference: DO:DOID:12215
database_cross_reference: DXP:U002916
database_cross_reference: HPO:HP:0001562
database_cross_reference: ICD10:O41.0
database_cross_reference: ICD10AM:O41.0
database_cross_reference: ICD10CM:O41.0
database_cross_reference: ICD10CM:O41.00
database_cross_reference: ICD9CM:658.0
database_cross_reference: MDR:10030289
database_cross_reference: MEDCIN:34307
database_cross_reference: MSH:D016104
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C92839
database_cross_reference: NCI_CDISC:C92839
database_cross_reference: NCI_NICHD:C92839
database_cross_reference: NDFRT:N0000003360
database_cross_reference: OMIM:MTHU036334
database_cross_reference: RCD:L280.
database_cross_reference: RCD:L2800
database_cross_reference: RCD:L280z
database_cross_reference: SNM:M-29440
database_cross_reference: SNMI:D8-22110
database_cross_reference: SNOMEDCT_US:156190009
database_cross_reference: SNOMEDCT_US:157051001
database_cross_reference: SNOMEDCT_US:199652007
database_cross_reference: SNOMEDCT_US:199656005
database_cross_reference: SNOMEDCT_US:59566000

Fetal polyuria
type: Class
subclass of: Abnormality of the amniotic fluid
definition: Abnormally increased production of urine by the fetus resulting in polyhydramnios.
PMOID: PMO:00004347
Subclass_of: Abnormality of the amniotic fluid
Tree Number: T3.7.3.1
database_cross_reference: HPO:HP:0001563

Abnormality of the integument
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the integument, which consists of the skin and the superficial fascia.
PMOID: PMO:00008730
Subclass_of: Phenotypic Abnormality
Tree Number: T3.16
database_cross_reference: HPO:HP:0001574

Abnormality of the hair
type: Class
subclass of: Abnormality of skin adnexa morphology
definition: An abnormality of the hair.
PMOID: PMO:00008732
Subclass_of: Abnormality of skin adnexa morphology
Synonym: Hair abnormality
Tree Number: T3.16.1.1
database_cross_reference: HPO:HP:0001595

Abnormality of the nail
type: Class
subclass of: Abnormality of skin adnexa morphology
definition: Abnormality of the nail.
PMOID: PMO:00008840
Subclass_of: Abnormality of skin adnexa morphology
Tree Number: T3.16.1.2

Vocal cord paralysis
type: Class
subclass of: Vocal cord dysfunction
definition: A loss of the ability to move the vocal folds.
PMOID: PMO:00014040
Subclass_of: Vocal cord dysfunction
Synonym: Inability to move vocal cords
Synonym: PARALYSIS VOCAL CORD
Synonym: Palsies, Vocal Cord
Synonym: Palsies, Vocal Fold
Synonym: Palsy, Vocal Cord
Synonym: Palsy, Vocal Fold
Synonym: Paralyses, Vocal Cord
Synonym: Paralysis of vocal cords
Synonym: Paralysis of vocal cords or larynx, unspecified
Synonym: Paralysis vocal cord
Tree Number: T3.22.11.2
database_cross_reference: CCPSS:0034969
database_cross_reference: CHV:0000013073
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:PARALYSIS VOCAL CORD
database_cross_reference: DXP:U004417
database_cross_reference: HPO:HP:0001605
database_cross_reference: ICD9CM:478.30
database_cross_reference: MDR:10033836
database_cross_reference: MDR:10046089
database_cross_reference: MDR:10047674
database_cross_reference: MEDCIN:30804
database_cross_reference: MSH:D014826
database_cross_reference: MTHICD9:478.30
database_cross_reference: NCI:C47814
database_cross_reference: NCI_NICHD:C47814
database_cross_reference: NDFRT:N0000003139
database_cross_reference: OMIM:MTHU014952
database_cross_reference: OMIM:MTHU025606
database_cross_reference: RCD:Xa9Bv
database_cross_reference: SNM:D-X761
database_cross_reference: SNMI:D2-04610
database_cross_reference: SNOMEDCT_US:155542001
database_cross_reference: SNOMEDCT_US:302912005
database_cross_reference: SNOMEDCT_US:87424003

Abnormality of the voice
type: Class
subclass of: Phenotypic Abnormality
PMOID: PMO:00014019
Subclass_of: Phenotypic Abnormality
Synonym: Voice abnormality
Tree Number: T3.22
database_cross_reference: HPO:HP:0001608

Hoarse voice
type: Class
subclass of: Abnormality of the voice
definition: Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.
PMOID: PMO:00014032
Subclass_of: Abnormality of the voice
Synonym: Croaky voice
Synonym: Dysphonia
Synonym: HOARSENESS
Synonym: Hoarse
Synonym: Hoarse (finding)
Synonym: Hoarse voice quality
Synonym: Hoarseness
Synonym: Hoarseness - throat symptom
Synonym: Hoarseness [Disease/Finding]
Synonym: Hoarseness of Voice
Tree Number: T3.22.6
database_cross_reference: BI:BI00184
database_cross_reference: CCPSS:1017331
database_cross_reference: CHV:0000006207
database_cross_reference: COSTAR:375
database_cross_reference: CST:VOICE ALTERAT
database_cross_reference: DXP:U004420
database_cross_reference: HPO:HP:0001609
database_cross_reference: ICD10CM:R49.0
database_cross_reference: ICPC2P:R23004
database_cross_reference: LCH:U002207
database_cross_reference: LCH_NW:sh85061307
database_cross_reference: MDR:10020200
database_cross_reference: MDR:10020201
database_cross_reference: MDR:10020202
database_cross_reference: MEDCIN:217
database_cross_reference: MSH:D006685
database_cross_reference: MTH:U003301
database_cross_reference: MTHICD9:784.42
database_cross_reference: NCI:C47813
database_cross_reference: NCI_CTCAE:E13384
database_cross_reference: NCI_NICHD:C47813
database_cross_reference: NDFRT:N0000001549
database_cross_reference: OMIM:MTHU036364
database_cross_reference: OMIM:MTHU038765
database_cross_reference: RCD:1CA2.
database_cross_reference: RCD:1CAZ.
database_cross_reference: RCD:R0445
database_cross_reference: RCDSY:R0445
database_cross_reference: SNM:F-X6480
database_cross_reference: SNMI:F-F7260
database_cross_reference: SNOMEDCT_US:139661005
database_cross_reference: SNOMEDCT_US:139663008
database_cross_reference: SNOMEDCT_US:139664002
database_cross_reference: SNOMEDCT_US:158311009
database_cross_reference: SNOMEDCT_US:162391002
database_cross_reference: SNOMEDCT_US:162393004
database_cross_reference: SNOMEDCT_US:206974000
database_cross_reference: SNOMEDCT_US:50219008

Nasal speech
type: Class
subclass of: Abnormality of the voice
definition: A type of speech characterized by the presence of an abnormally increased nasal airflow during speech.
PMOID: PMO:00014036
Subclass_of: Abnormality of the voice
Synonym: Hypernasal speech
Synonym: Hypernasal voice
Synonym: Nasal voice
Tree Number: T3.22.9
database_cross_reference: HPO:HP:0001611

Weak cry
type: Class
subclass of: Abnormal cry
PMOID: PMO:00014024
Subclass_of: Abnormal cry
Tree Number: T3.22.1.4
database_cross_reference: HPO:HP:0001612

Hoarse cry
type: Class
subclass of: Hoarse voice
PMOID: PMO:00014033
Subclass_of: Hoarse voice
Tree Number: T3.22.6.1
database_cross_reference: HPO:HP:0001615

Dysphonia
type: Class
subclass of: Abnormality of the voice
definition: An impairment in the ability to produce voice sounds.
PMOID: PMO:00014029
Subclass_of: Abnormality of the voice
Synonym: Croaky voice
Synonym: HOARSENESS
Synonym: Hoarse
Synonym: Hoarse (finding)
Synonym: Hoarse voice
Synonym: Hoarse voice quality
Synonym: Hoarseness
Synonym: Hoarseness - throat symptom
Synonym: Hoarseness [Disease/Finding]
Synonym: Hoarseness of Voice
Tree Number: T3.22.4
database_cross_reference: BI:BI00184
database_cross_reference: CCPSS:1017331
database_cross_reference: CHV:0000006207
database_cross_reference: COSTAR:375
database_cross_reference: CST:VOICE ALTERAT
database_cross_reference: DXP:U004420
database_cross_reference: HPO:HP:0001609
database_cross_reference: ICD10CM:R49.0
database_cross_reference: ICPC2P:R23004
database_cross_reference: LCH:U002207
database_cross_reference: LCH_NW:sh85061307
database_cross_reference: MDR:10020200
database_cross_reference: MDR:10020201
database_cross_reference: MDR:10020202
database_cross_reference: MEDCIN:217
database_cross_reference: MSH:D006685
database_cross_reference: MTH:U003301
database_cross_reference: MTHICD9:784.42
database_cross_reference: NCI:C47813
database_cross_reference: NCI_CTCAE:E13384
database_cross_reference: NCI_NICHD:C47813
database_cross_reference: NDFRT:N0000001549
database_cross_reference: OMIM:MTHU036364
database_cross_reference: OMIM:MTHU038765
database_cross_reference: RCD:1CA2.
database_cross_reference: RCD:1CAZ.
database_cross_reference: RCD:R0445
database_cross_reference: RCDSY:R0445
database_cross_reference: SNM:F-X6480
database_cross_reference: SNMI:F-F7260
database_cross_reference: SNOMEDCT_US:139661005
database_cross_reference: SNOMEDCT_US:139663008
database_cross_reference: SNOMEDCT_US:139664002
database_cross_reference: SNOMEDCT_US:158311009
database_cross_reference: SNOMEDCT_US:162391002
database_cross_reference: SNOMEDCT_US:162393004
database_cross_reference: SNOMEDCT_US:206974000
database_cross_reference: SNOMEDCT_US:50219008

High pitched voice
type: Class
subclass of: Abnormality of the voice
definition: An abnormal increase in the pitch (frequency) of the voice.
PMOID: PMO:00014031
Subclass_of: Abnormality of the voice
Synonym: High-pitched voice
Tree Number: T3.22.5
database_cross_reference: HPO:HP:0001620

Weak voice
type: Class
subclass of: Abnormality of the voice
definition: Reduced intensity (volume) of speech.
PMOID: PMO:00014046
Subclass_of: Abnormality of the voice
Synonym: Decreased vocal loudness
Synonym: Fatigue, Voice
Synonym: Fatigues, Voice
Synonym: Soft voice
Synonym: VOICE FATIGUE
Synonym: Vocal fatigue
Synonym: Vocal fatigue (finding)
Synonym: Voice Fatigue
Synonym: Voice Fatigues
Synonym: Voice fatigue
Tree Number: T3.22.12
database_cross_reference: CHV:0000024646
database_cross_reference: DXP:U004419
database_cross_reference: HPO:HP:0001621
database_cross_reference: MEDCIN:281063
database_cross_reference: MSH:D014832
database_cross_reference: RCD:Ub1SY
database_cross_reference: SNMI:F-F7234
database_cross_reference: SNOMEDCT_US:8614008

Premature birth
type: Class
subclass of: Abnormality of prenatal development or birth
definition: The birth of a baby of less than 37 weeks of gestational age.
PMOID: PMO:00004381
Subclass_of: Abnormality of prenatal development or birth
Synonym: Premature delivery
Synonym: Premature delivery of affected infants
Synonym: Preterm delivery
Synonym: Shortened gestation time
Tree Number: T3.7.10
database_cross_reference: HPO:HP:0001622

Breech presentation
type: Class
subclass of: Abnormal delivery
definition: A position of the fetus at delivery in which the fetus enters the birth canal with the buttocks or feet first.
PMOID: PMO:00004294
Subclass_of: Abnormal delivery
Synonym: BREECH PRESENTATION
Synonym: Breech Fetal Presentation
Synonym: Breech Labor Presentation
Synonym: Breech Presentation
Synonym: Breech Presentation [Disease/Finding]
Synonym: Breech delivery
Synonym: Breech delivery (disorder)
Synonym: Breech presentation (disorder)
Synonym: Breech presentation (finding)
Synonym: Breech presentation NOS
Tree Number: T3.7.1.1
database_cross_reference: CCPSS:0063154
database_cross_reference: CHV:0000002161
database_cross_reference: DXP:U000476
database_cross_reference: HPO:HP:0001623
database_cross_reference: HPO:HP:0010859
database_cross_reference: HPO:HP:0010860
database_cross_reference: HPO:HP:0010861
database_cross_reference: MDR:10006356
database_cross_reference: MEDCIN:291676
database_cross_reference: MEDCIN:34291
database_cross_reference: MEDCIN:9456
database_cross_reference: MSH:D001946
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34438
database_cross_reference: NCI_NICHD:C34438
database_cross_reference: NDFRT:N0000011068
database_cross_reference: OMIM:MTHU000028
database_cross_reference: OMIM:MTHU006183
database_cross_reference: RCD:L2220
database_cross_reference: RCD:L222z
database_cross_reference: RCD:X76TN
database_cross_reference: RCD:XE0w1
database_cross_reference: SNM:F-34280
database_cross_reference: SNMI:F-87280
database_cross_reference: SNOMEDCT_US:156157009
database_cross_reference: SNOMEDCT_US:156257003
database_cross_reference: SNOMEDCT_US:199352000
database_cross_reference: SNOMEDCT_US:199353005
database_cross_reference: SNOMEDCT_US:199356002
database_cross_reference: SNOMEDCT_US:249101006
database_cross_reference: SNOMEDCT_US:6096002

Abnormality of the cardiovascular system
type: Class
subclass of: Phenotypic Abnormality
definition: Any abnormality of the cardiovascular system.
PMOID: PMO:00004441
Subclass_of: Phenotypic Abnormality
Synonym: ABNORM CARDIOVASC
Synonym: Abnormalities, Cardiovascular
Synonym: Abnormality, Cardiovascular
Synonym: CARDIOVASC ABNORM
Synonym: CARDIOVASCULAR ABNORMALITY
Synonym: Cardiovascular Abnormalities
Synonym: Cardiovascular Abnormalities [Disease/Finding]
Synonym: Cardiovascular Abnormality
Synonym: Cardiovascular abnormality
Synonym: Cardiovascular system--Abnormalities
Tree Number: T3.9
database_cross_reference: CHV:0000025094
database_cross_reference: DXP:U000554
database_cross_reference: HPO:HP:0001626
database_cross_reference: LCH_NW:sh85020227
database_cross_reference: MSH:D018376
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003808

Abnormal heart morphology
type: Class
subclass of: Abnormality of cardiovascular system morphology
definition: Any structural anomaly of the heart.
PMOID: PMO:00004451
Subclass_of: Abnormality of cardiovascular system morphology
Synonym: 4-31 CONGENITAL ANOMALIES OF THE HEART
Synonym: ABNORM HEART
Synonym: ANOMALY CARDIAC
Synonym: ANOMALY HEART
Synonym: Abnormalities, Heart
Synonym: Abnormality of cardiac morphology
Synonym: Abnormality of the heart
Synonym: Abnormality, Heart
Synonym: Anomaly cardiac
Synonym: Anomaly heart
Tree Number: T3.9.2.1
database_cross_reference: AOD:0000005254
database_cross_reference: CCPSS:0043687
database_cross_reference: CHV:0000005874
database_cross_reference: COSTAR:U000203
database_cross_reference: CSP:0724-8315
database_cross_reference: CST:ANOMALY HEART
database_cross_reference: DO:DOID:1682
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000547
database_cross_reference: HPO:HP:0001627
database_cross_reference: HPO:HP:0002564
database_cross_reference: ICD10:Q24.9
database_cross_reference: ICD10AM:Q24.9
database_cross_reference: ICD10CM:Q24.9
database_cross_reference: ICD9CM:746.9
database_cross_reference: ICPC2P:K73004
database_cross_reference: LCH_NW:sh85059634
database_cross_reference: MDR:10002616
database_cross_reference: MDR:10002626
database_cross_reference: MDR:10019293
database_cross_reference: MDR:10025528
database_cross_reference: MDR:10045703
database_cross_reference: MEDCIN:33162
database_cross_reference: MEDLINEPLUS:198
database_cross_reference: MSH:D006330
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:746.9
database_cross_reference: NCI:C34666
database_cross_reference: NDFRT:N0000001431
database_cross_reference: OMIM:140500
database_cross_reference: OMIM:234750
database_cross_reference: OMIM:MTHU008662
database_cross_reference: OMIM:MTHU013668
database_cross_reference: OMIM:MTHU021246
database_cross_reference: OMIM:MTHU024793
database_cross_reference: OMIM:MTHU033032
database_cross_reference: OMIM:MTHU036327
database_cross_reference: RCD:P6zz.
database_cross_reference: SNMI:D4-31000
database_cross_reference: SNOMEDCT_US:13213009
database_cross_reference: SNOMEDCT_US:156911006
database_cross_reference: SNOMEDCT_US:156926008
database_cross_reference: SNOMEDCT_US:204405005
database_cross_reference: SNOMEDCT_US:204413006
database_cross_reference: SNOMEDCT_US:268315002
database_cross_reference: SNOMEDCT_US:268318000

Congestive heart failure
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.
PMOID: PMO:00004944
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: 3-16 HEART FAILURE AND OTHER FUNCTIONAL DISORDERS
Synonym: CARDIAC FAILURE
Synonym: CARDIAC INSUFFICIENCY
Synonym: CHF
Synonym: Cardiac Failure
Synonym: Cardiac Failure Congestive
Synonym: Cardiac Insufficiency
Synonym: Cardiac failure
Synonym: Cardiac failure (NOS)
Synonym: Cardiac failure NOS
Tree Number: T3.9.3.11
database_cross_reference: AOD:0000005305
database_cross_reference: AOD:0000005308
database_cross_reference: BI:BI00019
database_cross_reference: CCPSS:0017571
database_cross_reference: CHV:0000005877
database_cross_reference: CHV:0000050019
database_cross_reference: COSTAR:U000338
database_cross_reference: CSP:1393-3587
database_cross_reference: CST:HEART FAIL
database_cross_reference: DO:DOID:6000
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0001635
database_cross_reference: ICD10:I50
database_cross_reference: ICD10:I50.9
database_cross_reference: ICD10AM:I50
database_cross_reference: ICD10AM:I50.9
database_cross_reference: ICD10CM:I50
database_cross_reference: ICD10CM:I50.9
database_cross_reference: ICD9CM:428
database_cross_reference: ICD9CM:428.9
database_cross_reference: ICPC2EENG:K77
database_cross_reference: ICPC2P:K29019
database_cross_reference: ICPC2P:K77004
database_cross_reference: ICPC2P:K77011
database_cross_reference: ICPC2P:K77028
database_cross_reference: LCH:U005616
database_cross_reference: LCH_NW:sh85059745
database_cross_reference: MDR:10007554
database_cross_reference: MDR:10007555
database_cross_reference: MDR:10007562
database_cross_reference: MDR:10007568
database_cross_reference: MDR:10007569
database_cross_reference: MDR:10007582
database_cross_reference: MDR:10016145
database_cross_reference: MDR:10019279
database_cross_reference: MDR:10019280
database_cross_reference: MDR:10019282
database_cross_reference: MDR:10019285
database_cross_reference: MDR:10019290
database_cross_reference: MDR:10022462
database_cross_reference: MEDCIN:95724
database_cross_reference: MEDLINEPLUS:199
database_cross_reference: MSH:D006333
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:428.9
database_cross_reference: NCI:C50577
database_cross_reference: NCI_CTCAE:E10124
database_cross_reference: NCI_FDA:2206
database_cross_reference: NCI_NICHD:C50577
database_cross_reference: OMIM:MTHU009472
database_cross_reference: OMIM:MTHU012782
database_cross_reference: OMIM:MTHU052864
database_cross_reference: RCD:G58..
database_cross_reference: RCD:XE0V9
database_cross_reference: SNM:D-7050
database_cross_reference: SNMI:D3-16000
database_cross_reference: SNOMEDCT_US:155374007
database_cross_reference: SNOMEDCT_US:155375008
database_cross_reference: SNOMEDCT_US:155377000
database_cross_reference: SNOMEDCT_US:195117009
database_cross_reference: SNOMEDCT_US:266248006
database_cross_reference: SNOMEDCT_US:266308000
database_cross_reference: SNOMEDCT_US:84114007

Myocardial infarction
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin.
PMOID: PMO:00004951
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: -- Heart Attack
Synonym: AMI
Synonym: ATTACK CORONARY
Synonym: ATTACK HEART (NOS)
Synonym: Ami
Synonym: Attack - heart
Synonym: Attack coronary
Synonym: Attack heart (NOS)
Synonym: Cardiac infarct
Synonym: Cardiac infarction
Tree Number: T3.9.3.12
database_cross_reference: AOD:0000005332
database_cross_reference: AOD:0000023334
database_cross_reference: AOD:0000023335
database_cross_reference: BI:BI00102
database_cross_reference: CCPSS:1018028
database_cross_reference: CHV:0000008423
database_cross_reference: COSTAR:505
database_cross_reference: CSP:1393-3417
database_cross_reference: CST:CORONARY ART DIS
database_cross_reference: CST:INFARCT MYOCARD
database_cross_reference: DO:DOID:5844
database_cross_reference: DRUGBANK:DB00548
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0001658
database_cross_reference: ICD10CM:I21
database_cross_reference: ICD10CM:I22
database_cross_reference: ICPC2P:K75001
database_cross_reference: ICPC2P:K75013
database_cross_reference: ICPC2P:K75014
database_cross_reference: LCH_NW:sh85059683
database_cross_reference: LNC:LA10558-7
database_cross_reference: LNC:LA14274-7
database_cross_reference: LNC:LP98884-7
database_cross_reference: LNC:MTHU035551
database_cross_reference: MDR:10003723
database_cross_reference: MDR:10003724
database_cross_reference: MDR:10019250
database_cross_reference: MDR:10021758
database_cross_reference: MDR:10027524
database_cross_reference: MDR:10028595
database_cross_reference: MDR:10028596
database_cross_reference: MEDCIN:353001
database_cross_reference: MEDLINEPLUS:5
database_cross_reference: MSH:D009203
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:410.9
database_cross_reference: NCI:C27996
database_cross_reference: NCI_CTCAE:E10152
database_cross_reference: NCI_FDA:1969
database_cross_reference: NCI_NICHD:C27996
database_cross_reference: NDFRT:N0000002085
database_cross_reference: OMIM:MTHU002361
database_cross_reference: OMIM:MTHU008101
database_cross_reference: PSY:22465
database_cross_reference: PSY:25140
database_cross_reference: PSY:32820
database_cross_reference: RCD:X200E
database_cross_reference: SNM:D-7256
database_cross_reference: SNM:M-54700
database_cross_reference: SNMI:D3-15000
database_cross_reference: SNOMEDCT_US:155304006
database_cross_reference: SNOMEDCT_US:194796000
database_cross_reference: SNOMEDCT_US:22298006
database_cross_reference: SNOMEDCT_US:233824008
database_cross_reference: SNOMEDCT_US:266288001
database_cross_reference: SNOMEDCT_US:66514008
database_cross_reference: SNOMEDCT_VET:22298006

Angina pectoris
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: Paroxysmal chest pain that occurs with exertion or stress and is related to myocardial ischemia.
PMOID: PMO:00004943
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: 3-12 ANGINAL SYNDROMES
Synonym: ANGINA
Synonym: ANGINA PECTORIS
Synonym: ANGINAL PAIN
Synonym: ANGINAL SYNDROME
Synonym: ANGINAL SYNDROMES
Synonym: AP - Angina pectoris
Synonym: Angina
Synonym: Angina (disorder)
Synonym: Angina NOS
Tree Number: T3.9.3.10
database_cross_reference: AOD:0000005328
database_cross_reference: AOD:0000005330
database_cross_reference: AOD:0000023333
database_cross_reference: BI:BI00018
database_cross_reference: BI:BI00047
database_cross_reference: CCPSS:1017852
database_cross_reference: CHV:0000001165
database_cross_reference: COSTAR:053
database_cross_reference: COSTAR:054
database_cross_reference: CSP:1393-3407
database_cross_reference: CST:ANGINA PECTORIS
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000113
database_cross_reference: DXP:U000178
database_cross_reference: HPO:HP:0001681
database_cross_reference: ICD10:I20
database_cross_reference: ICD10:I20.9
database_cross_reference: ICD10AM:I20
database_cross_reference: ICD10AM:I20.9
database_cross_reference: ICD10CM:I20
database_cross_reference: ICD10CM:I20.8
database_cross_reference: ICD10CM:I20.9
database_cross_reference: ICD9CM:413
database_cross_reference: ICPC2EENG:K74
database_cross_reference: ICPC2P:K74001
database_cross_reference: ICPC2P:K74002
database_cross_reference: LCH:U000244
database_cross_reference: LCH_NW:sh85005022
database_cross_reference: LNC:LA14275-4
database_cross_reference: MDR:10002372
database_cross_reference: MDR:10002383
database_cross_reference: MDR:10002387
database_cross_reference: MDR:10002391
database_cross_reference: MDR:10002393
database_cross_reference: MDR:10041972
database_cross_reference: MDR:10054224
database_cross_reference: MDR:10056256
database_cross_reference: MDR:10056259
database_cross_reference: MEDCIN:33215
database_cross_reference: MEDCIN:354217
database_cross_reference: MEDLINEPLUS:142
database_cross_reference: MSH:D000787
database_cross_reference: MTH:053
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:413.9
database_cross_reference: NCI:C51221
database_cross_reference: NCI_CTCAE:E10110
database_cross_reference: NCI_FDA:1710
database_cross_reference: NCI_NICHD:C51221
database_cross_reference: NDFRT:N0000000406
database_cross_reference: OMIM:MTHU008097
database_cross_reference: OMIM:MTHU009903
database_cross_reference: PSY:02530
database_cross_reference: RCD:G33..
database_cross_reference: RCD:G33z.
database_cross_reference: RCD:G33z1
database_cross_reference: RCD:Ua1eH
database_cross_reference: RCDAE:G33..
database_cross_reference: RCDAE:Ua1eH
database_cross_reference: SNM:D-7253
database_cross_reference: SNM:F-71500
database_cross_reference: SNMI:D3-12000
database_cross_reference: SNOMEDCT_US:155307004
database_cross_reference: SNOMEDCT_US:17828002

Loss of voice
type: Class
subclass of: Abnormality of the voice
PMOID: PMO:00014035
Subclass_of: Abnormality of the voice
Synonym: APHONIA
Synonym: Absence of Voice
Synonym: Absence of voice
Synonym: Aphonia
Synonym: Aphonia (disorder)
Synonym: Aphonia [Disease/Finding]
Synonym: Does not phonate
Synonym: Does not produce voice
Synonym: Does not produce voice (finding)
Synonym: Does not vocalise
Tree Number: T3.22.8
database_cross_reference: CHV:0000001374
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:VOICE ALTERAT
database_cross_reference: DXP:U000219
database_cross_reference: HPO:HP:0001686
database_cross_reference: ICD10:R49.1
database_cross_reference: ICD10AM:R49.1
database_cross_reference: ICD10CM:R49.1
database_cross_reference: ICD9CM:784.41
database_cross_reference: ICPC2P:R23001
database_cross_reference: ICPC2P:R23005
database_cross_reference: MDR:10002953
database_cross_reference: MDR:10024882
database_cross_reference: MEDCIN:203706
database_cross_reference: MSH:D001044
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:784.41
database_cross_reference: NCI:C79539
database_cross_reference: NCI_CTCAE:E12589
database_cross_reference: NCI_NICHD:C79539
database_cross_reference: NDFRT:N0000000453
database_cross_reference: OMIM:MTHU037052
database_cross_reference: RCD:R0441
database_cross_reference: RCD:R0442
database_cross_reference: RCD:Ub1SK
database_cross_reference: RCD:Xa3RH
database_cross_reference: RCD:Xa7Hx
database_cross_reference: RCDSY:R0441
database_cross_reference: RCDSY:R0442
database_cross_reference: SNM:F-X6530
database_cross_reference: SNMI:F-F7005
database_cross_reference: SNOMEDCT_US:158307003
database_cross_reference: SNOMEDCT_US:158308008
database_cross_reference: SNOMEDCT_US:206970009
database_cross_reference: SNOMEDCT_US:206971008
database_cross_reference: SNOMEDCT_US:286329004
database_cross_reference: SNOMEDCT_US:286359009
database_cross_reference: SNOMEDCT_US:299702006
database_cross_reference: SNOMEDCT_US:441913003
database_cross_reference: SNOMEDCT_US:44564008

Abnormality of the pancreas
type: Class
subclass of: Abnormality of the abdominal organs
definition: An abnormality of the pancreas.
PMOID: PMO:00005503
Subclass_of: Abnormality of the abdominal organs
Tree Number: T3.10.4.3
database_cross_reference: HPO:HP:0001732

Abnormality of the spleen
type: Class
subclass of: Abnormality of the lymphatic system
definition: An abnormality of the spleen.
PMOID: PMO:00008699
Subclass_of: Abnormality of the lymphatic system
Tree Number: T3.15.3.3
database_cross_reference: HPO:HP:0001743

Abnormality of the foot
type: Class
subclass of: Abnormality of the lower limb
definition: An abnormality of the skeleton of foot.
PMOID: PMO:00002730
Subclass_of: Abnormality of the lower limb
Synonym: Abnormal feet morphology
Synonym: Abnormality of the feet
Synonym: Deformities, Foot
Synonym: Deformity of foot
Synonym: Deformity of foot (finding)
Synonym: Deformity, Foot
Synonym: FOOT DEFORMITY
Synonym: Foot Deformities
Synonym: Foot Deformities [Disease/Finding]
Synonym: Foot Deformity
Tree Number: T3.5.2.4
database_cross_reference: CHV:0000005189
database_cross_reference: DXP:U001562
database_cross_reference: HPO:HP:0001760
database_cross_reference: LCH_NW:sh85050353
database_cross_reference: MDR:10016966
database_cross_reference: MDR:10061159
database_cross_reference: MEDCIN:10738
database_cross_reference: MSH:D005530
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000001272
database_cross_reference: OMIM:MTHU001017
database_cross_reference: OMIM:MTHU004518
database_cross_reference: RCD:Ub1oa
database_cross_reference: SNOMEDCT_US:229844004

Abnormal delivery
type: Class
subclass of: Abnormality of prenatal development or birth
definition: An abnormality of the birth process.
PMOID: PMO:00004293
Subclass_of: Abnormality of prenatal development or birth
Synonym: Abnormal delivery (finding)
Synonym: Abnormal delivery (history)
Synonym: DELIVERY ABNORMAL
Synonym: peripartum history delivery abnormal
Tree Number: T3.7.1
database_cross_reference: CST:MATFETDEL
database_cross_reference: HPO:HP:0001787
database_cross_reference: MEDCIN:129372
database_cross_reference: RCD:XM0tc
database_cross_reference: SNOMEDCT_US:156251002
database_cross_reference: SNOMEDCT_US:267352004
database_cross_reference: SNOMEDCT_US:274127000

Premature rupture of membranes
type: Class
subclass of: Abnormal delivery
definition: Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor.
PMOID: PMO:00004305
Subclass_of: Abnormal delivery
Synonym: Fetal Membranes, Premature Rupture
Synonym: Fetal Membranes, Premature Rupture [Disease/Finding]
Synonym: Fetal membranes, premature rupture
Synonym: MEMBRANE RUPTURE PREMATURE
Synonym: Membrane Premature Rupture (Pregnancy)
Synonym: Membrane Premature Ruptures (Pregnancy)
Synonym: Membrane-prem. rupture
Synonym: PROM
Synonym: PROM (Pregnancy)
Synonym: PROM - Prem rupt membranes
Tree Number: T3.7.1.7
database_cross_reference: CCPSS:0043301
database_cross_reference: CHV:0000004997
database_cross_reference: HPO:HP:0001788
database_cross_reference: ICD10:O42
database_cross_reference: ICD10:O42.9
database_cross_reference: ICD10AM:O42
database_cross_reference: ICD10AM:O42.9
database_cross_reference: ICD10CM:O42
database_cross_reference: ICD9CM:658.1
database_cross_reference: ICPC2P:W84027
database_cross_reference: LNC:LA20068-5
database_cross_reference: LNC:LA21777-0
database_cross_reference: MDR:10036603
database_cross_reference: MEDCIN:34308
database_cross_reference: MSH:D005322
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87113
database_cross_reference: NCI_NICHD:C87113
database_cross_reference: NDFRT:N0000001237
database_cross_reference: OMIM:MTHU037411
database_cross_reference: RCD:L281.
database_cross_reference: RCD:L2810
database_cross_reference: RCD:L281z
database_cross_reference: RCD:X40Bg
database_cross_reference: SNM:F-31830
database_cross_reference: SNMI:D8-22120
database_cross_reference: SNOMEDCT_US:156189000
database_cross_reference: SNOMEDCT_US:156191008
database_cross_reference: SNOMEDCT_US:157050000
database_cross_reference: SNOMEDCT_US:199657001
database_cross_reference: SNOMEDCT_US:199663005
database_cross_reference: SNOMEDCT_US:237266003
database_cross_reference: SNOMEDCT_US:267338001
database_cross_reference: SNOMEDCT_US:44223004

Autoamputation of foot
type: Class
subclass of: Autoamputation
definition: Spontaneous detachment of a foot from the body.
PMOID: PMO:00003470
Subclass_of: Autoamputation
Tree Number: T3.5.6.2
database_cross_reference: HPO:HP:0001868

Abnormality of blood and blood-forming tissues
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the hematopoietic system.
PMOID: PMO:00000905
Subclass_of: Phenotypic Abnormality
Synonym: Abnormal;haematological
Synonym: Abnormal;hematological
Synonym: Abnormality of the hematopoietic system
Synonym: Hematological abnormality
Synonym: haematological abnormality
Synonym: hematological abnormality
Tree Number: T3.2
database_cross_reference: HPO:HP:0001871
database_cross_reference: ICPC2P:B86001
database_cross_reference: ICPC2P:B99016

Abnormal thrombocyte morphology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: An abnormality of platelets.
PMOID: PMO:00001040
Subclass_of: Abnormality of blood and blood-forming tissues
Tree Number: T3.2.5

Abnormal erythrocyte morphology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: Any structural abnormality of erythrocytes (red-blood cells).
PMOID: PMO:00000924
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: 631-634 ABNORMAL RED BLOOD CELLS
Synonym: ABNORM ERYTHROCYTES
Synonym: ABNORMAL RED BLOOD CELLS
Synonym: Abnormal Erythrocyte
Synonym: Abnormal Erythrocytes
Synonym: Abnormal Red Blood Cell
Synonym: Abnormal erythrocyte
Synonym: Abnormal erythrocyte, NOS
Synonym: Abnormal red blood cell
Synonym: Abnormal red blood cell (cell)
Tree Number: T3.2.2
database_cross_reference: CHV:0000004630
database_cross_reference: HPO:HP:0001877
database_cross_reference: MSH:D004913
database_cross_reference: MTH:U003408
database_cross_reference: NCI:C12522
database_cross_reference: SNMI:M-63100
database_cross_reference: SNOMEDCT_US:12222001
database_cross_reference: SNOMEDCT_US:397019006

Abnormal leukocyte morphology
type: Class
subclass of: Abnormality of cellular immune system
definition: An abnormality of leukocytes.
PMOID: PMO:00008251
Subclass_of: Abnormality of cellular immune system
Synonym: Abnormal leukocyte function
Synonym: Abnormality of leukocytes
Tree Number: T3.15.1.1
database_cross_reference: HPO:HP:0001881

Abnormal bleeding
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.
PMOID: PMO:00000906
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: BLEEDING ABNORMAL
Synonym: BLEEDING DIATHESIS
Synonym: BLEEDING DISORDER
Synonym: BLEEDING TENDENCY
Synonym: Bleeding Diathesis
Synonym: Bleeding Disorders
Synonym: Bleeding Predisposition
Synonym: Bleeding Tendency
Synonym: Bleeding diathesis
Synonym: Bleeding diathesis (disorder)
Tree Number: T3.2.1
database_cross_reference: CCPSS:0018175
database_cross_reference: CCPSS:0061000
database_cross_reference: CHV:0000047284
database_cross_reference: COSTAR:U000080
database_cross_reference: CST:HEM
database_cross_reference: HPO:HP:0001892
database_cross_reference: ICPC2P:B28001
database_cross_reference: MDR:10005133
database_cross_reference: MDR:10005134
database_cross_reference: MDR:10018967
database_cross_reference: MDR:10055261
database_cross_reference: MEDLINEPLUS:166
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C115221
database_cross_reference: NCI:NMDP/CIBMTR
database_cross_reference: OMIM:MTHU000442
database_cross_reference: OMIM:MTHU012705
database_cross_reference: OMIM:MTHU016228
database_cross_reference: OMIM:MTHU026263
database_cross_reference: RCD:D30..
database_cross_reference: RCD:X76A9
database_cross_reference: SNMI:F-D0730
database_cross_reference: SNOMEDCT_US:123329004
database_cross_reference: SNOMEDCT_US:248250000
database_cross_reference: SNOMEDCT_US:267562007
database_cross_reference: SNOMEDCT_US:64779008
database_cross_reference: SNOMEDCT_US:78596001

Polycythemia
type: Class
subclass of: Abnormal erythrocyte morphology
definition: Polycythemia is diagnosed if the red blood cell count, the hemoglobin level, and the red blood cell volume all exceed the upper limits of normal.
PMOID: PMO:00001026
Subclass_of: Abnormal erythrocyte morphology
Synonym: Abnormally shaped erythrocytes
Synonym: Erythrocythaemia
Synonym: Erythrocythemia
Synonym: POLYCYTHAEMIA
Synonym: POLYCYTHEMIA
Synonym: Polycythaemia
Synonym: Polycythaemia NOS
Synonym: Polycythaemia, NOS
Synonym: Polycythemia NOS
Synonym: Polycythemia [Disease/Finding]
Tree Number: T3.2.2.16
database_cross_reference: AOD:0000005927
database_cross_reference: CCPSS:0037624
database_cross_reference: CHV:0000009910
database_cross_reference: COSTAR:594
database_cross_reference: CSP:0427-4465
database_cross_reference: CST:POLYCYTHEMIA
database_cross_reference: DO:DOID:8432
database_cross_reference: DXP:U003191
database_cross_reference: HPO:HP:0001901
database_cross_reference: ICD10CM:D75.1
database_cross_reference: LCH:U003753
database_cross_reference: LCH_NW:sh85104610
database_cross_reference: MDR:10036051
database_cross_reference: MDR:10036055
database_cross_reference: MDR:10036058
database_cross_reference: MEDCIN:363009
database_cross_reference: MSH:D011086
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000162
database_cross_reference: MTH:U000165
database_cross_reference: NCI:C26863
database_cross_reference: NCI_NICHD:C26863
database_cross_reference: NDFRT:N0000002453
database_cross_reference: OMIM:MTHU006480
database_cross_reference: RCD:X20D8
database_cross_reference: RCDAE:X20D8
database_cross_reference: SNM:M-77700
database_cross_reference: SNM:U000386
database_cross_reference: SNMI:DC-38000
database_cross_reference: SNOMEDCT_US:109992005
database_cross_reference: SNOMEDCT_US:127062003
database_cross_reference: SNOMEDCT_US:165401000
database_cross_reference: SNOMEDCT_US:44865000

Anemia
type: Class
subclass of: Abnormal erythrocyte morphology
definition: A reduction in erythrocytes volume or hemoglobin concentration.
PMOID: PMO:00000964
Subclass_of: Abnormal erythrocyte morphology
Synonym: ANAEMIA
Synonym: ANEMIA
Synonym: Anaemia
Synonym: Anaemia (disorder)
Synonym: Anaemia NOS
Synonym: Anaemia unspecified
Synonym: Anaemia unspecified (disorder)
Synonym: Anaemia, NOS
Synonym: Anaemia, unspecified
Synonym: Anemia (disorder)
Tree Number: T3.2.2.10
database_cross_reference: AOD:0000005870
database_cross_reference: AOD:0000023514
database_cross_reference: BI:BI00026
database_cross_reference: CCPSS:1017210
database_cross_reference: CHV:0000001118
database_cross_reference: COSTAR:051
database_cross_reference: CSP:0427-0313
database_cross_reference: CST:ANEMIA
database_cross_reference: DO:DOID:2355
database_cross_reference: DXP:U000172
database_cross_reference: HPO:HP:0001903
database_cross_reference: ICD10:D64.9
database_cross_reference: ICD10AM:D64.9
database_cross_reference: ICD10AMAE:D64.9
database_cross_reference: ICD10CM:D64.9
database_cross_reference: ICD9CM:285.9
database_cross_reference: ICPC2P:B82005
database_cross_reference: LCH:U000235
database_cross_reference: LCH_NW:sh85004940
database_cross_reference: LNC:LA18969-8
database_cross_reference: LNC:MTHU020823
database_cross_reference: MDR:10002034
database_cross_reference: MDR:10002071
database_cross_reference: MDR:10002082
database_cross_reference: MDR:10002272
database_cross_reference: MDR:10002315
database_cross_reference: MDR:10045627
database_cross_reference: MDR:10055742
database_cross_reference: MEDCIN:30320
database_cross_reference: MEDLINEPLUS:139
database_cross_reference: MSH:D000740
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000161
database_cross_reference: MTH:U000164
database_cross_reference: MTHICD9:285.9
database_cross_reference: NCI:C2869
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_CTCAE:E10010
database_cross_reference: NCI_FDA:1706
database_cross_reference: NCI_NCI-GLOSS:CDR0000045360
database_cross_reference: NCI_NICHD:C2869
database_cross_reference: NDFRT:N0000000384
database_cross_reference: OMIM:MTHU002606
database_cross_reference: PDQ:CDR0000041382
database_cross_reference: PSY:02450
database_cross_reference: RCD:XE140
database_cross_reference: RCD:XM05A
database_cross_reference: RCDAE:XE140
database_cross_reference: RCDAE:XM05A
database_cross_reference: SNM:D-4010
database_cross_reference: SNMI:DC-10010
database_cross_reference: SNOMEDCT_US:154786001
database_cross_reference: SNOMEDCT_US:154812000
database_cross_reference: SNOMEDCT_US:191277004
database_cross_reference: SNOMEDCT_US:267531008
database_cross_reference: SNOMEDCT_US:271737000
database_cross_reference: SNOMEDCT_US:64593003

Thromboembolism
type: Class
subclass of: Abnormal thrombosis
definition: The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site.
PMOID: PMO:00001109
Subclass_of: Abnormal thrombosis
Synonym: Embolism and thrombosis of unspecified site
Synonym: Other venous embolism and thrombosis of unspecified site
Synonym: THROMBOEMBOLIC DISEASE
Synonym: THROMBOEMBOLISM
Synonym: Thromboembolic Event
Synonym: Thromboembolic disease
Synonym: Thromboembolic disorder
Synonym: Thromboembolic disorder (disorder)
Synonym: Thromboembolic event
Synonym: Thromboembolic events
Tree Number: T3.2.6.4
database_cross_reference: AOD:0000005941
database_cross_reference: CCPSS:0036096
database_cross_reference: CHV:0000012222
database_cross_reference: CHV:0000050545
database_cross_reference: CSP:0571-3989
database_cross_reference: CST:EMB
database_cross_reference: HPO:HP:0001907
database_cross_reference: ICD9CM:453.9
database_cross_reference: LCH:U004669
database_cross_reference: LCH_NW:sh85135071
database_cross_reference: MDR:10014511
database_cross_reference: MDR:10043565
database_cross_reference: MDR:10043566
database_cross_reference: MDR:10043567
database_cross_reference: MEDCIN:95291
database_cross_reference: MSH:D013923
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:453.9
database_cross_reference: NCI:C28195
database_cross_reference: NCI_CTCAE:E13825
database_cross_reference: NCI_FDA:2654
database_cross_reference: NCI_NICHD:C28195
database_cross_reference: NDFRT:N0000002934
database_cross_reference: OMIM:MTHU008847
database_cross_reference: OMIM:MTHU010071
database_cross_reference: PDQ:CDR0000037886
database_cross_reference: RCD:XaBUu
database_cross_reference: SNM:M-35300
database_cross_reference: SNMI:M-35310
database_cross_reference: SNOMEDCT_US:134356002
database_cross_reference: SNOMEDCT_US:13713005
database_cross_reference: SNOMEDCT_US:371039008

Leukemia
type: Class
subclass of: Hematological neoplasm
definition: A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.
PMOID: PMO:00001216
Subclass_of: Hematological neoplasm
Synonym: -- Leukemia
Synonym: 980 LEUKEMIAS, NOS
Synonym: 980-994 LEUKEMIAS
Synonym: Aleukaemic leukaemia [obs]
Synonym: Aleukemic leukemia [obs]
Synonym: Blood (Leukemia)
Synonym: Chronic leukaemia [obs]
Synonym: Chronic leukemia [obs]
Synonym: LEUKAEMIA
Synonym: LEUKEMIA
Tree Number: T3.2.10.1
database_cross_reference: AOD:0000004617
database_cross_reference: BI:BI00316
database_cross_reference: CCPSS:0051957
database_cross_reference: CHV:0000007330
database_cross_reference: CHV:0000049549
database_cross_reference: COSTAR:U000412
database_cross_reference: CSP:2004-1566
database_cross_reference: CST:LEUKEMIA
database_cross_reference: DO:DOID:1240
database_cross_reference: DXP:U002348
database_cross_reference: HPO:HP:0001909
database_cross_reference: ICD10:C95
database_cross_reference: ICD10:C95.9
database_cross_reference: ICD10AM:C95
database_cross_reference: ICD10AM:C95.9
database_cross_reference: ICD10AM:C95.90
database_cross_reference: ICD10AM:M9800/3
database_cross_reference: ICD10AMAE:C95
database_cross_reference: ICD10AMAE:C95.9
database_cross_reference: ICD10AMAE:C95.90
database_cross_reference: ICD10AMAE:M9800/3
database_cross_reference: ICD10CM:C95
database_cross_reference: ICD10CM:C95.9
database_cross_reference: ICD10CM:C95.90
database_cross_reference: ICD9CM:208
database_cross_reference: ICD9CM:208.9
database_cross_reference: ICPC2EENG:B73
database_cross_reference: ICPC2P:B73001
database_cross_reference: LCH:U002665
database_cross_reference: LCH_NW:sh85076285
database_cross_reference: LNC:LA10545-4
database_cross_reference: MDR:10024288
database_cross_reference: MDR:10024312
database_cross_reference: MDR:10024314
database_cross_reference: MDR:10024323
database_cross_reference: MDR:10024324
database_cross_reference: MDR:10024329
database_cross_reference: MDR:10024351
database_cross_reference: MDR:10024352
database_cross_reference: MDR:10045991
database_cross_reference: MDR:10045992
database_cross_reference: MDR:10045994
database_cross_reference: MDR:10060430
database_cross_reference: MDR:10060500
database_cross_reference: MEDCIN:31470
database_cross_reference: MEDLINEPLUS:5620
database_cross_reference: MSH:D007938
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:208.9
database_cross_reference: NCI:C3161
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3161
database_cross_reference: NCI_CTEP-SDC:10024312
database_cross_reference: NCI_NCI-GLOSS:CDR0000045343
database_cross_reference: NCI_NICHD:C3161
database_cross_reference: NDFRT:N0000001815
database_cross_reference: OMIM:MTHU008966
database_cross_reference: PDQ:CDR0000041186
database_cross_reference: PSY:28260
database_cross_reference: RCD:B68..
database_cross_reference: RCD:B68z.
database_cross_reference: RCD:BBr..
database_cross_reference: RCD:BBr0.
database_cross_reference: RCD:BBr00

Renal amyloidosis
type: Class
subclass of: Amyloidosis
definition: A form of amyloidosis that affects the kidney.
PMOID: PMO:00004248
Subclass_of: Amyloidosis
Synonym: Amyloid nephropathy
Synonym: Amyloid nephropathy (disorder)
Synonym: Lardaceous kidney
Synonym: Nephropathic amyloidosis
Synonym: Soapy kidney
Synonym: Waxy kidney
Synonym: amyloid nephropathy
Synonym: amyloid nephropathy (diagnosis)
Synonym: renal amyloidosis
Synonym: waxy kidney
Tree Number: T3.6.24.8
database_cross_reference: CHV:0000026300
database_cross_reference: HPO:HP:0001917
database_cross_reference: MDR:10038357
database_cross_reference: MEDCIN:30692
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU011698
database_cross_reference: RCD:C3736
database_cross_reference: SNMI:D6-94540
database_cross_reference: SNOMEDCT_US:48713002

Abnormality of coagulation
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: An abnormality of the process of blood coagulation. That is, altered ability or inability of the blood to clot.
PMOID: PMO:00001147
Subclass_of: Abnormality of blood and blood-forming tissues
Tree Number: T3.2.8

Persistent bleeding after trauma
type: Class
subclass of: Abnormal bleeding
PMOID: PMO:00000917
Subclass_of: Abnormal bleeding
Synonym: Excessive bleeding after minor trauma
Synonym: Frequent bleeding with trauma
Synonym: Prolonged bleeding after minor trauma
Tree Number: T3.2.1.10
database_cross_reference: HPO:HP:0001934

Abnormality of metabolism/homeostasis
type: Class
subclass of: Phenotypic Abnormality
PMOID: PMO:00003474
Subclass_of: Phenotypic Abnormality
Synonym: Laboratory abnormality
Synonym: Metabolism abnormality
Tree Number: T3.6
database_cross_reference: HPO:HP:0001939

Acidosis
type: Class
subclass of: Abnormality of acid-base homeostasis
definition: Abnormal acid accumulation or depletion of base.
PMOID: PMO:00003605
Subclass_of: Abnormality of acid-base homeostasis
Synonym: ACIDOSIS
Synonym: Acidoses
Synonym: Acidosis (disorder)
Synonym: Acidosis NOS
Synonym: Acidosis NOS (disorder)
Synonym: Acidosis [Disease/Finding]
Synonym: Acidosis, NOS
Synonym: acidemia
Synonym: acidoses
Synonym: acidosis
Tree Number: T3.6.8.3
database_cross_reference: AOD:0000005821
database_cross_reference: CCPSS:0063443
database_cross_reference: CHV:0000000634
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0465-0952
database_cross_reference: CST:ACIDOSIS
database_cross_reference: CST:METACIDOSIS
database_cross_reference: DXP:U000077
database_cross_reference: HPO:HP:0001941
database_cross_reference: ICD10:E87.2
database_cross_reference: ICD10AM:E87.2
database_cross_reference: ICD10CM:E87.2
database_cross_reference: ICD9CM:276.2
database_cross_reference: LCH:U000036
database_cross_reference: LCH_NW:sh85000531
database_cross_reference: MDR:10000486
database_cross_reference: MDR:10000493
database_cross_reference: MEDCIN:338589
database_cross_reference: MSH:D000138
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000118
database_cross_reference: MTHICD9:276.2
database_cross_reference: NCI:C83504
database_cross_reference: NDFRT:N0000000283
database_cross_reference: RCD:C362.
database_cross_reference: RCD:C362z
database_cross_reference: SNMI:D6-23100
database_cross_reference: SNOMEDCT_US:154757004
database_cross_reference: SNOMEDCT_US:190887001
database_cross_reference: SNOMEDCT_US:51387008

Dehydration
type: Class
subclass of: Abnormality of fluid regulation
PMOID: PMO:00003975
Subclass_of: Abnormality of fluid regulation
Synonym: DEHYDRATION
Synonym: Deficient fluid volume
Synonym: Dehydrated
Synonym: Dehydration (disorder)
Synonym: Dehydration [Disease/Finding]
Synonym: Dehydration syndrome
Synonym: Exsiccosis
Synonym: Pure water depletion syndrome
Synonym: body water dehydration
Synonym: deficient fluid volume
Tree Number: T3.6.13.1
database_cross_reference: AOD:0000005833
database_cross_reference: CCPSS:1015105
database_cross_reference: CHV:0000003663
database_cross_reference: COSTAR:220
database_cross_reference: CSP:0465-2856
database_cross_reference: CST:DEHYDRAT
database_cross_reference: DXP:U000936
database_cross_reference: HPO:HP:0001944
database_cross_reference: ICD10CM:E86.0
database_cross_reference: ICD9CM:276.51
database_cross_reference: ICPC2EENG:T11
database_cross_reference: ICPC2P:T11001
database_cross_reference: LNC:MTHU020843
database_cross_reference: MDR:10012174
database_cross_reference: MDR:10054198
database_cross_reference: MEDLINEPLUS:6051
database_cross_reference: MSH:D003681
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26740
database_cross_reference: NCI_CTCAE:E12258
database_cross_reference: NCI_FDA:1807
database_cross_reference: NCI_NCI-GLOSS:CDR0000044659
database_cross_reference: NCI_NICHD:C26740
database_cross_reference: NDFRT:N0000000911
database_cross_reference: OMIM:MTHU000177
database_cross_reference: PSY:13285
database_cross_reference: RCD:XM00s
database_cross_reference: SNM:D-1172
database_cross_reference: SNM:F-01790
database_cross_reference: SNMI:D6-20650
database_cross_reference: SNOMEDCT_US:154759001
database_cross_reference: SNOMEDCT_US:34095006
database_cross_reference: SNOMEDCT_US:37472003

Fever
type: Class
subclass of: Abnormality of temperature regulation
definition: Elevated body temperature due to failed thermoregulation.
PMOID: PMO:00004186
Subclass_of: Abnormality of temperature regulation
Synonym: BODY TEMPERATURE INCREASED
Synonym: Body temperature above normal
Synonym: Body temperature above normal (finding)
Synonym: Body temperature above reference range
Synonym: Body temperature above reference range (finding)
Synonym: Body temperature increased
Synonym: Body temperature, increased
Synonym: Elevated Core Body Temperature
Synonym: FEVER
Synonym: Febrile
Tree Number: T3.6.21.1
database_cross_reference: AOD:0000004396
database_cross_reference: AOD:0000004726
database_cross_reference: AOD:0000022968
database_cross_reference: BI:BI00751
database_cross_reference: CCPSS:0015064
database_cross_reference: CCPSS:1017166
database_cross_reference: CHV:0000005010
database_cross_reference: CHV:0000022653
database_cross_reference: CHV:0000022654
database_cross_reference: COSTAR:300
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2871-4310
database_cross_reference: CST:FEVER
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001483
database_cross_reference: GO:GO:0001660
database_cross_reference: HPO:HP:0001945
database_cross_reference: ICD10:R50.9
database_cross_reference: ICD10AM:R50.9
database_cross_reference: ICD10CM:R50.9
database_cross_reference: ICD9CM:780.60
database_cross_reference: ICPC2EENG:A03
database_cross_reference: ICPC2P:A03002
database_cross_reference: ICPC2P:A03006
database_cross_reference: LCH:U001776
database_cross_reference: LCH_NW:sh85047994
database_cross_reference: LNC:LA9540-1
database_cross_reference: LNC:MTHU013245
database_cross_reference: LNC:MTHU013518
database_cross_reference: MDR:10005911
database_cross_reference: MDR:10016558
database_cross_reference: MDR:10020083
database_cross_reference: MDR:10020843
database_cross_reference: MDR:10037660
database_cross_reference: MDR:10037663
database_cross_reference: MDR:10037668
database_cross_reference: MDR:10043204
database_cross_reference: MDR:10073718
database_cross_reference: MEDCIN:278512
database_cross_reference: MEDCIN:314447
database_cross_reference: MEDCIN:6005
database_cross_reference: MEDLINEPLUS:511
database_cross_reference: MSH:D005334
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.60
database_cross_reference: NCI:C3038
database_cross_reference: NCI:C50589
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CTCAE:E11102
database_cross_reference: NCI_FDA:1858
database_cross_reference: NCI_FDA:1909
database_cross_reference: NCI_NCI-GLOSS:CDR0000450108
database_cross_reference: NCI_NCI-GLOSS:CDR0000468790
database_cross_reference: NCI_NICHD:C3038
database_cross_reference: NCI_NICHD:C50589
database_cross_reference: NDFRT:N0000001242
database_cross_reference: OMIM:MTHU005439
database_cross_reference: OMIM:MTHU015481
database_cross_reference: PSY:19660
database_cross_reference: PSY:23840
database_cross_reference: RCD:R0062
database_cross_reference: RCD:X76Df
database_cross_reference: RCD:X76Di
database_cross_reference: RCD:X76EI

Ketosis
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: Presence of elevated levels of ketone bodies in the body.
PMOID: PMO:00004263
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: High levels of ketone bodies
Synonym: KETOSIS
Synonym: Ketoacidoses
Synonym: Ketoacidosis
Synonym: Ketosis (disorder)
Synonym: Ketosis [Disease/Finding]
Synonym: Ketosis, NOS
Synonym: ketosis
Tree Number: T3.6.31
database_cross_reference: CCPSS:1006662
database_cross_reference: CHV:0000007081
database_cross_reference: CST:KETOSIS
database_cross_reference: HPO:HP:0001946
database_cross_reference: ICPC2P:T99076
database_cross_reference: MDR:10023391
database_cross_reference: MSH:D007662
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000292
database_cross_reference: MTH:U000380
database_cross_reference: NDFRT:N0000001745
database_cross_reference: OMIM:MTHU011496
database_cross_reference: RCD:Xa9zp
database_cross_reference: SNMI:D6-23410
database_cross_reference: SNOMEDCT_US:2538008

Alkalosis
type: Class
subclass of: Abnormality of acid-base homeostasis
definition: Depletion of acid or accumulation base in the body fluids.
PMOID: PMO:00003630
Subclass_of: Abnormality of acid-base homeostasis
Synonym: ALKALOSIS
Synonym: Alkaloses
Synonym: Alkalosis (disorder)
Synonym: Alkalosis NOS
Synonym: Alkalosis NOS (disorder)
Synonym: Alkalosis [Disease/Finding]
Synonym: Alkalosis, NOS
Synonym: alkaloses
Synonym: alkalosis
Synonym: alkalosis (diagnosis)
Tree Number: T3.6.8.4
database_cross_reference: AOD:0000005830
database_cross_reference: CCPSS:1007046
database_cross_reference: CHV:0000000900
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0465-1418
database_cross_reference: CST:ALKALOSIS
database_cross_reference: CST:METALKALOSIS
database_cross_reference: DXP:U000131
database_cross_reference: HPO:HP:0001948
database_cross_reference: ICD10:E87.3
database_cross_reference: ICD10AM:E87.3
database_cross_reference: ICD10CM:E87.3
database_cross_reference: ICD9CM:276.3
database_cross_reference: LCH:U000148
database_cross_reference: LCH_NW:sh85003603
database_cross_reference: MDR:10001680
database_cross_reference: MDR:10001687
database_cross_reference: MEDCIN:338591
database_cross_reference: MSH:D000471
database_cross_reference: MTH:U000119
database_cross_reference: MTHICD9:276.3
database_cross_reference: NCI:C37909
database_cross_reference: NCI_CTCAE:E12247
database_cross_reference: NDFRT:N0000000355
database_cross_reference: OMIM:MTHU054076
database_cross_reference: RCD:C363.
database_cross_reference: RCD:C363z
database_cross_reference: SNMI:D6-24000
database_cross_reference: SNOMEDCT_US:154758009
database_cross_reference: SNOMEDCT_US:190892004
database_cross_reference: SNOMEDCT_US:21420006

Episodic ammonia intoxication
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
PMOID: PMO:00004160
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.7
database_cross_reference: HPO:HP:0001951

Diabetic ketoacidosis
type: Class
subclass of: Diabetes mellitus
definition: A type of diabetic metabolic abnormality with an accumulation of ketone bodies.
PMOID: PMO:00006363
Subclass_of: Diabetes mellitus
Synonym: ACIDOSIS DIABETIC
Synonym: ACIDOSIS, DIABETIC
Synonym: Acidoses, Diabetic
Synonym: Acidosis diabetic
Synonym: Acidosis, Diabetic
Synonym: DIABETES MELLITUS, KETOSIS-PRONE
Synonym: DIABETIC ACIDOSIS
Synonym: DKA
Synonym: DKA - Diabetic ketoacidosis
Synonym: DKA - diabetic ketoacidosis
Tree Number: T3.12.13.1
database_cross_reference: AOD:0000005829
database_cross_reference: CCPSS:1017906
database_cross_reference: CHV:0000003844
database_cross_reference: CHV:0000037747
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0862-6200
database_cross_reference: CST:ACIDOSIS DIABET
database_cross_reference: DO:DOID:1837
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000969
database_cross_reference: DXP:U002245
database_cross_reference: HPO:HP:0001953
database_cross_reference: ICD9CM:250.1
database_cross_reference: LCH_NW:sh85037467
database_cross_reference: MDR:10000488
database_cross_reference: MDR:10012622
database_cross_reference: MDR:10012632
database_cross_reference: MDR:10012642
database_cross_reference: MDR:10012671
database_cross_reference: MDR:10012673
database_cross_reference: MDR:10023380
database_cross_reference: MEDCIN:30483
database_cross_reference: MSH:D016883
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000381
database_cross_reference: NCI:C50530
database_cross_reference: NCI_FDA:2364
database_cross_reference: NCI_NICHD:C50530
database_cross_reference: NDFRT:N0000003499
database_cross_reference: OMIM:MTHU010100
database_cross_reference: RCD:C101.
database_cross_reference: RCD:C101z
database_cross_reference: SNM:D-2394
database_cross_reference: SNMI:DB-62010
database_cross_reference: SNOMEDCT_US:154671004
database_cross_reference: SNOMEDCT_US:190328004
database_cross_reference: SNOMEDCT_US:24927004
database_cross_reference: SNOMEDCT_US:267467004
database_cross_reference: SNOMEDCT_US:420422005

Abnormality of the scalp
type: Class
subclass of: Abnormality of the head
definition: Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows.
PMOID: PMO:00002230
Subclass_of: Abnormality of the head
Synonym: Anomaly of scalp
Tree Number: T3.4.1.3
database_cross_reference: HPO:HP:0001965

Abnormal thrombosis
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis).
PMOID: PMO:00001103
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: Abnormal blood clot
Tree Number: T3.2.6
database_cross_reference: HPO:HP:0001977

Extramedullary hematopoiesis
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms.
PMOID: PMO:00001214
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: Extramedullary Hematopoieses
Synonym: Extramedullary Hematopoiesis
Synonym: Extramedullary Hematopoiesis Function
Synonym: Hematopoieses, Extramedullary
Synonym: Hematopoiesis, Extramedullary
Synonym: extramedullary haematopoiesis
Synonym: extramedullary hematopoiesis
Tree Number: T3.2.9
database_cross_reference: CHV:0000005959
database_cross_reference: MSH:D006411
database_cross_reference: MTH:NOCODE

Intolerance to protein
type: Class
subclass of: Food intolerance
PMOID: PMO:00004253
Subclass_of: Food intolerance
Synonym: Malabsorption caused by intolerance to protein
Synonym: Malabsorption caused by intolerance to protein (disorder)
Synonym: Malabsorption due to intolerance to protein
Synonym: Malabsorption due to intolerance to protein (disorder)
Tree Number: T3.6.27.1
database_cross_reference: ICD10CM:K90.49
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:Xa9CB
database_cross_reference: SNOMEDCT_US:302921006

Ketoacidosis
type: Class
subclass of: Ketosis
definition: Acidosis resulting from accumulation of ketone bodies.
PMOID: PMO:00004264
Subclass_of: Ketosis
Synonym: High levels of ketone bodies
Synonym: KETOSIS
Synonym: Ketoacidoses
Synonym: Ketosis
Synonym: Ketosis (disorder)
Synonym: Ketosis [Disease/Finding]
Synonym: Ketosis, NOS
Synonym: ketosis
Tree Number: T3.6.31.1
database_cross_reference: CCPSS:1006662
database_cross_reference: CHV:0000007081
database_cross_reference: CST:KETOSIS
database_cross_reference: HPO:HP:0001946
database_cross_reference: ICPC2P:T99076
database_cross_reference: MDR:10023391
database_cross_reference: MSH:D007662
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000292
database_cross_reference: MTH:U000380
database_cross_reference: NDFRT:N0000001745
database_cross_reference: OMIM:MTHU011496
database_cross_reference: RCD:Xa9zp
database_cross_reference: SNMI:D6-23410
database_cross_reference: SNOMEDCT_US:2538008

Morphological abnormality of the central nervous system
type: Class
subclass of: Abnormality of nervous system morphology
definition: A structural abnormality of the central nervous system.
PMOID: PMO:00009896
Subclass_of: Abnormality of nervous system morphology
Synonym: Abnormality of the central nervous system
Tree Number: T3.18.2.4
database_cross_reference: HPO:HP:0002011

Abnormality of the abdominal organs
type: Class
subclass of: Abnormality of the digestive system
definition: An abnormality of the viscera of the abdomen.
PMOID: PMO:00005371
Subclass_of: Abnormality of the digestive system
Synonym: Gastrointestinal tract defects
Tree Number: T3.10.4
database_cross_reference: HPO:HP:0002012

Dysphagia
type: Class
subclass of: Abnormality of nervous system physiology
definition: Difficulty in swallowing.
PMOID: PMO:00011193
Subclass_of: Abnormality of nervous system physiology
Synonym: Can't get food down
Synonym: Cannot get food down
Synonym: DEGLUTITION DIS
Synonym: DEGLUTITION DISORDER
Synonym: DISORDER DEGLUTITION
Synonym: DYSPHAGIA
Synonym: Deglutition Disorder
Synonym: Deglutition Disorders
Synonym: Deglutition Disorders [Disease/Finding]
Synonym: Deglutition disorder
Tree Number: T3.18.3.15
database_cross_reference: AOD:0000005507
database_cross_reference: BI:BI00239
database_cross_reference: CCPSS:1014574
database_cross_reference: CHV:0000003662
database_cross_reference: COSTAR:265
database_cross_reference: CSP:5000-0052
database_cross_reference: CST:DYSPHAGIA
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001012
database_cross_reference: HPO:HP:0002015
database_cross_reference: HPO:HP:0200136
database_cross_reference: ICD10:R13
database_cross_reference: ICD10AM:R13
database_cross_reference: ICD10CM:R13.1
database_cross_reference: ICD10CM:R13.10
database_cross_reference: ICD9CM:787.2
database_cross_reference: ICD9CM:787.20
database_cross_reference: ICPC2P:D21003
database_cross_reference: ICPC2P:D21004
database_cross_reference: LCH_NW:sh85036477
database_cross_reference: LNC:MTHU029874
database_cross_reference: MDR:10012173
database_cross_reference: MDR:10013213
database_cross_reference: MDR:10013950
database_cross_reference: MDR:10042645
database_cross_reference: MDR:10042646
database_cross_reference: MEDCIN:312702
database_cross_reference: MEDCIN:399
database_cross_reference: MEDLINEPLUS:1309
database_cross_reference: MSH:D003680
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:787.20
database_cross_reference: NCI:C2980
database_cross_reference: NCI_CTCAE:E10621
database_cross_reference: NCI_FDA:1815
database_cross_reference: NCI_NCI-GLOSS:CDR0000044666
database_cross_reference: NCI_NICHD:C2980
database_cross_reference: NDFRT:N0000000910
database_cross_reference: OMIM:MTHU036443
database_cross_reference: OMIM:MTHU036956
database_cross_reference: OMIM:MTHU037360
database_cross_reference: OMIM:MTHU037782
database_cross_reference: OMIM:MTHU038534
database_cross_reference: OMIM:MTHU056733
database_cross_reference: PDQ:CDR0000524080
database_cross_reference: PSY:15654
database_cross_reference: RCD:R072.
database_cross_reference: RCD:R0720
database_cross_reference: RCD:R072z
database_cross_reference: RCD:XM08J
database_cross_reference: RCD:Xa4JZ
database_cross_reference: RCDSY:R072.
database_cross_reference: RCDSY:R0720
database_cross_reference: RCDSY:R072z
database_cross_reference: SNM:F-61020
database_cross_reference: SNMI:D5-30250
database_cross_reference: SNOMEDCT_US:139289002
database_cross_reference: SNOMEDCT_US:158429003
database_cross_reference: SNOMEDCT_US:158430008
database_cross_reference: SNOMEDCT_US:158431007
database_cross_reference: SNOMEDCT_US:162022009
database_cross_reference: SNOMEDCT_US:207121004
database_cross_reference: SNOMEDCT_US:207122006
database_cross_reference: SNOMEDCT_US:207123001

Abdominal pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
PMOID: PMO:00014075
Subclass_of: Pain
Synonym: ABDOMEN PAIN
Synonym: ABDOMINAL PAIN
Synonym: ABDOMINAL PAIN NOS
Synonym: AP - Abdominal pain
Synonym: Abd. pain
Synonym: Abdmnal pain unspcf site
Synonym: Abdo pain
Synonym: Abdominal Pain
Synonym: Abdominal Pain [Disease/Finding]
Synonym: Abdominal Pains
Tree Number: T3.23.10.1
database_cross_reference: AOD:0000005516
database_cross_reference: BI:BI00206
database_cross_reference: CCPSS:1017336
database_cross_reference: CHV:0000000535
database_cross_reference: COSTAR:004
database_cross_reference: COSTAR:U000001
database_cross_reference: CST:PAIN ABDO
database_cross_reference: DXP:U000023
database_cross_reference: HPO:HP:0002027
database_cross_reference: ICD10CM:R10.9
database_cross_reference: ICD9CM:789.0
database_cross_reference: ICD9CM:789.00
database_cross_reference: ICPC2P:D01006
database_cross_reference: LCH_NW:sh85000111
database_cross_reference: LNC:LA15468-4
database_cross_reference: LNC:MTHU013636
database_cross_reference: MDR:10000039
database_cross_reference: MDR:10000040
database_cross_reference: MDR:10000081
database_cross_reference: MDR:10000085
database_cross_reference: MDR:10018796
database_cross_reference: MDR:10033373
database_cross_reference: MDR:10033374
database_cross_reference: MEDCIN:475
database_cross_reference: MEDLINEPLUS:3061
database_cross_reference: MSH:D015746
database_cross_reference: MTH:306
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26682
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CTCAE:E10460
database_cross_reference: NCI_FDA:1685
database_cross_reference: NCI_NICHD:C26682
database_cross_reference: NDFRT:N0000003309
database_cross_reference: OMIM:MTHU036407
database_cross_reference: RCD:1969.
database_cross_reference: RCD:R090.
database_cross_reference: RCD:R090z
database_cross_reference: RCDSY:R090.
database_cross_reference: RCDSY:R090z
database_cross_reference: SNMI:F-50860
database_cross_reference: SNOMEDCT_US:139313005
database_cross_reference: SNOMEDCT_US:158498003
database_cross_reference: SNOMEDCT_US:158512003
database_cross_reference: SNOMEDCT_US:207205003
database_cross_reference: SNOMEDCT_US:207230000
database_cross_reference: SNOMEDCT_US:21522001

Hypothermia
type: Class
subclass of: Abnormality of temperature regulation
definition: Reduced body temperature due to failed thermoregulation.
PMOID: PMO:00004191
Subclass_of: Abnormality of temperature regulation
Synonym: Abnormally low body temperature
Tree Number: T3.6.21.3
database_cross_reference: HPO:HP:0002045

Heat intolerance
type: Class
subclass of: Abnormality of temperature regulation
definition: The inability to maintain a comfortably body temperature in warm or hot weather.
PMOID: PMO:00004190
Subclass_of: Abnormality of temperature regulation
Synonym: Gets overheated
Synonym: HEAT INTOLERANCE
Synonym: HEAT SENSITIVITY
Synonym: Heat sensitivity
Synonym: Intolerance to heat and fevers
Synonym: Intolerant of heat
Synonym: Intolerant of heat (finding)
Synonym: Sensitive to heat
Synonym: heat intolerance
Synonym: heat sensitive
Tree Number: T3.6.21.2
database_cross_reference: CCPSS:0029041
database_cross_reference: CHV:0000022656
database_cross_reference: COSTAR:U000326
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001918
database_cross_reference: HPO:HP:0002046
database_cross_reference: MDR:10019339
database_cross_reference: MDR:10056596
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU007764
database_cross_reference: OMIM:MTHU016858
database_cross_reference: RCD:X76Ea
database_cross_reference: SNM:F-03170
database_cross_reference: SNMI:F-03170
database_cross_reference: SNOMEDCT_US:69215007
database_cross_reference: SNOMEDCT_VET:69215007

Malignant hyperthermia
type: Class
subclass of: Abnormality of temperature regulation
definition: Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C in response to inhalational anesthetics such as halothane or to muscle relaxants such as succinylcholine.
PMOID: PMO:00004194
Subclass_of: Abnormality of temperature regulation
Synonym: Anesthesia Hyperthermia
Synonym: Anesthesia Hyperthermias
Synonym: Anesthesia Related Hyperthermia
Synonym: Anesthesia Related Hyperthermias
Synonym: FEVER MALIGNANT
Synonym: Fever malignant
Synonym: HYPERPYREXIA MALIGNANT
Synonym: HYPERPYREXIA, FULMINATING
Synonym: HYPERPYREXIA, MALIGNANT
Synonym: HYPERTHERMIA MALIGNANT
Tree Number: T3.6.21.5
database_cross_reference: CCPSS:0046783
database_cross_reference: CHV:0000007696
database_cross_reference: CHV:0000058199
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2871-4352
database_cross_reference: CST:FEVER MALIGNANT
database_cross_reference: DO:DOID:8545
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000888
database_cross_reference: HPO:HP:0002047
database_cross_reference: ICD10:T88.3
database_cross_reference: ICD10AM:T88.3
database_cross_reference: ICD10AMAE:T88.3
database_cross_reference: ICD10CM:T88.3
database_cross_reference: ICD9CM:995.86
database_cross_reference: ICPC2P:A03007
database_cross_reference: LCH:U002793
database_cross_reference: LCH_NW:sh85080155
database_cross_reference: MDR:10016561
database_cross_reference: MDR:10020742
database_cross_reference: MDR:10020844
database_cross_reference: MDR:10025599
database_cross_reference: MDR:10025606
database_cross_reference: MDR:10025607
database_cross_reference: MEDCIN:311081
database_cross_reference: MEDCIN:33656
database_cross_reference: MSH:D008305
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:995.86
database_cross_reference: NCI:C84869
database_cross_reference: NCI_NICHD:C84869
database_cross_reference: NDFRT:N0000001928
database_cross_reference: OMIM:145600
database_cross_reference: OMIM:180901
database_cross_reference: OMIM:MTHU023121
database_cross_reference: RCD:SN5y0
database_cross_reference: RCD:X709O
database_cross_reference: RCDAE:SN5y0
database_cross_reference: SNM:D-1065
database_cross_reference: SNMI:DD-64B00
database_cross_reference: SNOMEDCT_US:111738008
database_cross_reference: SNOMEDCT_US:157762007
database_cross_reference: SNOMEDCT_US:213026003
database_cross_reference: SNOMEDCT_US:248453001
database_cross_reference: SNOMEDCT_US:269435009
database_cross_reference: SNOMEDCT_US:405500008
database_cross_reference: SNOMEDCT_US:405501007

Abnormality of the respiratory system
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles.
PMOID: PMO:00011354
Subclass_of: Phenotypic Abnormality
Synonym: Respiratory abnormality
Tree Number: T3.19
database_cross_reference: HPO:HP:0002086
database_cross_reference: MTH:NOCODE

Abnormality of the upper respiratory tract
type: Class
subclass of: Abnormal respiratory system morphology
definition: An abnormality of the upper respiratory tract.
PMOID: PMO:00011493
Subclass_of: Abnormal respiratory system morphology
Tree Number: T3.19.1.5
database_cross_reference: HPO:HP:0002087

Abnormal lung morphology
type: Class
subclass of: Abnormal respiratory system morphology
definition: Any structural anomaly of the lung.
PMOID: PMO:00011356
Subclass_of: Abnormal respiratory system morphology
Tree Number: T3.19.1.1

Restrictive ventilatory defect
type: Class
subclass of: Functional respiratory abnormality
definition: A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus.
PMOID: PMO:00011664
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.21

Respiratory insufficiency
type: Class
subclass of: Functional respiratory abnormality
PMOID: PMO:00011650
Subclass_of: Functional respiratory abnormality
Synonym: INCOMPETENCE PULM VALVE
Synonym: INSUFFICIENCY PULM VALVE
Synonym: Incompetence, Pulmonary Valve
Synonym: Insufficiency, Pulmonary
Synonym: Insufficiency, Pulmonary Valve
Synonym: PR - Pulmonary regurgitation
Synonym: PULM REGURGITATION
Synonym: PULM VALVE INCOMPETENCE
Synonym: PULM VALVE INSUFFICIENCY
Synonym: PULM VALVE REGURGITATION
Tree Number: T3.19.2.20
database_cross_reference: BI:BI00107
database_cross_reference: CCPSS:0022933
database_cross_reference: CHV:0000010397
database_cross_reference: CSP:1393-3857
database_cross_reference: DO:DOID:14265
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001619
database_cross_reference: HPO:HP:0010444
database_cross_reference: ICD10:I37.1
database_cross_reference: ICD10AM:I37.1
database_cross_reference: MDR:10037408
database_cross_reference: MDR:10037448
database_cross_reference: MDR:10051697
database_cross_reference: MDR:10052842
database_cross_reference: MEDCIN:33375
database_cross_reference: MSH:D011665
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:424.3
database_cross_reference: NCI:C50848
database_cross_reference: NCI:C51447
database_cross_reference: NCI:C62436
database_cross_reference: NCI_FDA:2022
database_cross_reference: NCI_FDA:2023
database_cross_reference: NDFRT:N0000002547
database_cross_reference: OMIM:MTHU014357
database_cross_reference: OMIM:MTHU021746
database_cross_reference: RCD:X201L
database_cross_reference: SNM:F-70500
database_cross_reference: SNMI:D3-29052
database_cross_reference: SNOMEDCT_US:91434003

Dyspnea
type: Class
subclass of: Functional respiratory abnormality
definition: Difficult or labored breathing.
PMOID: PMO:00011637
Subclass_of: Functional respiratory abnormality
Synonym: (Symptom: [SOB] or [breathlessness] or [dyspnea]) or (breathlessness)
Synonym: (Symptom: [SOB] or [breathlessness] or [dyspnoea]) or (breathlessness)
Synonym: (Symptom: [SOB] or [breathlessness] or [dyspnoea]) or (breathlessness) (finding)
Synonym: BREATH SHORTNESS
Synonym: BREATHING DIFFICULT
Synonym: BREATHLESSNESS
Synonym: Breath Shortness
Synonym: Breath Shortnesses
Synonym: Breath shortness
Synonym: Breathing Difficulties
Tree Number: T3.19.2.16
database_cross_reference: AOD:0000005442
database_cross_reference: BI:BI00181
database_cross_reference: BI:BI00182
database_cross_reference: CCPSS:1011301
database_cross_reference: CCPSS:1015304
database_cross_reference: CCPSS:1017161
database_cross_reference: CHV:0000004216
database_cross_reference: CHV:0000032132
database_cross_reference: COSTAR:266
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2596-2296
database_cross_reference: CST:DYSPNEA
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001014
database_cross_reference: HPO:HP:0002094
database_cross_reference: HPO:HP:0002880
database_cross_reference: ICD10:R06.0
database_cross_reference: ICD10AM:R06.0
database_cross_reference: ICD10AMAE:R06.0
database_cross_reference: ICD10CM:R06.0
database_cross_reference: ICD10CM:R06.00
database_cross_reference: ICD10CM:R06.02
database_cross_reference: ICD9CM:786.05
database_cross_reference: ICPC2EENG:R02
database_cross_reference: ICPC2P:R02001
database_cross_reference: ICPC2P:R02002
database_cross_reference: ICPC2P:R02004
database_cross_reference: ICPC2P:R02007
database_cross_reference: LCH:U001486
database_cross_reference: LCH_NW:sh85040344
database_cross_reference: LNC:LA17001-1
database_cross_reference: LNC:LA17611-7
database_cross_reference: LNC:LP115812-2
database_cross_reference: LNC:MTHU020850
database_cross_reference: LNC:MTHU038266
database_cross_reference: MDR:10006332
database_cross_reference: MDR:10006338
database_cross_reference: MDR:10006345
database_cross_reference: MDR:10012791
database_cross_reference: MDR:10013963
database_cross_reference: MDR:10013968
database_cross_reference: MDR:10013972
database_cross_reference: MDR:10013975
database_cross_reference: MDR:10040596
database_cross_reference: MDR:10040604
database_cross_reference: MDR:10041237
database_cross_reference: MDR:10041238
database_cross_reference: MEDCIN:115876
database_cross_reference: MEDCIN:353
database_cross_reference: MEDLINEPLUS:3077
database_cross_reference: MSH:D004417
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000486
database_cross_reference: NCI:C2998
database_cross_reference: NCI_CDISC:C2998
database_cross_reference: NCI_CTCAE:E13368
database_cross_reference: NCI_FDA:1816
database_cross_reference: NCI_NCI-GLOSS:CDR0000046183
database_cross_reference: NCI_NICHD:C2998
database_cross_reference: NDFRT:N0000001030
database_cross_reference: OMIM:MTHU037132
database_cross_reference: OMIM:MTHU037277
database_cross_reference: OMIM:MTHU038284
database_cross_reference: PSY:15680

Asthma
type: Class
subclass of: Functional respiratory abnormality
definition: Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.
PMOID: PMO:00011624
Subclass_of: Functional respiratory abnormality
Synonym: -- Asthma
Synonym: 2-51 ASTHMA
Synonym: ASTHMA
Synonym: ASTHMA BRONCHIAL
Synonym: ASTHMA, BRONCHIAL
Synonym: Airway hyperreactivity
Synonym: Asthma (disorder)
Synonym: Asthma (disorder) [Ambiguous]
Synonym: Asthma NOS
Synonym: Asthma NOS (disorder)
Tree Number: T3.19.2.12
database_cross_reference: AOD:0000005951
database_cross_reference: BI:BI00009
database_cross_reference: CCPSS:1017373
database_cross_reference: CHV:0000001541
database_cross_reference: CHV:0000050455
database_cross_reference: COSTAR:080
database_cross_reference: CSP:1525-2157
database_cross_reference: CST:ASTHMA
database_cross_reference: DO:DOID:2841
database_cross_reference: DXP:U000171
database_cross_reference: DXP:U000273
database_cross_reference: HPO:HP:0002099
database_cross_reference: ICD10:J45
database_cross_reference: ICD10:J45.9
database_cross_reference: ICD10AM:J45
database_cross_reference: ICD10AM:J45.9
database_cross_reference: ICD10CM:J45
database_cross_reference: ICD10CM:J45.90
database_cross_reference: ICD10CM:J45.909
database_cross_reference: ICD9CM:493
database_cross_reference: ICD9CM:493.9
database_cross_reference: ICPC2EENG:R96
database_cross_reference: ICPC2P:R96001
database_cross_reference: LCH:U000405
database_cross_reference: LCH_NW:sh85008860
database_cross_reference: LNC:LA10564-5
database_cross_reference: LNC:LA16982-3
database_cross_reference: LNC:MTHU020815
database_cross_reference: MDR:10003553
database_cross_reference: MDR:10003555
database_cross_reference: MDR:10003560
database_cross_reference: MDR:10003561
database_cross_reference: MDR:10003565
database_cross_reference: MDR:10006070
database_cross_reference: MDR:10006450
database_cross_reference: MEDCIN:32881
database_cross_reference: MEDLINEPLUS:2
database_cross_reference: MSH:D001249
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:493.9
database_cross_reference: NCI:C28397
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_FDA:1726
database_cross_reference: NCI_NCI-GLOSS:CDR0000440101
database_cross_reference: NCI_NICHD:C28397
database_cross_reference: NDFRT:N0000000498
database_cross_reference: OMIM:MTHU003537
database_cross_reference: OMIM:MTHU005153
database_cross_reference: PSY:04190
database_cross_reference: RCD:H33..
database_cross_reference: RCD:H33z.
database_cross_reference: RCD:XE0YX
database_cross_reference: SNM:D-4790
database_cross_reference: SNMI:D2-51000
database_cross_reference: SNOMEDCT_US:155574008
database_cross_reference: SNOMEDCT_US:155579003
database_cross_reference: SNOMEDCT_US:187687003
database_cross_reference: SNOMEDCT_US:195967001
database_cross_reference: SNOMEDCT_US:195979001
database_cross_reference: SNOMEDCT_US:195983001
database_cross_reference: SNOMEDCT_US:21341004
database_cross_reference: SNOMEDCT_US:266365004
database_cross_reference: SNOMEDCT_US:266398009

Hyperproteinemia
type: Class
subclass of: Abnormality of circulating protein level
definition: An increased concentration of proteins in the blood.
PMOID: PMO:00003965
Subclass_of: Abnormality of circulating protein level
Synonym: HYPERPROTEINEMIA
Synonym: Hyperproteinaemia
Synonym: Hyperproteinemia (disorder)
Synonym: Hyperproteinemia, NOS
Synonym: hyperproteinemia
Synonym: hyperproteinemia (diagnosis)
Tree Number: T3.6.12.19
database_cross_reference: CCPSS:0019965
database_cross_reference: CHV:0000026240
database_cross_reference: CSP:0449-5410
database_cross_reference: HPO:HP:0002152
database_cross_reference: MDR:10020740
database_cross_reference: MDR:10054418
database_cross_reference: MEDCIN:311892
database_cross_reference: SNM:F-12213
database_cross_reference: SNMI:D6-11010
database_cross_reference: SNOMEDCT_US:154750002
database_cross_reference: SNOMEDCT_US:267503004
database_cross_reference: SNOMEDCT_US:37064009
database_cross_reference: SNOMEDCT_VET:81647003

Azotemia
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: An increased concentration of nitrogen compounds in the blood.
PMOID: PMO:00004154
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: AZOTEMIA
Synonym: Azotaemia
Synonym: Azotemia (disorder)
Synonym: Azotemia (finding)
Synonym: Azotemia [Disease/Finding]
Synonym: azotaemia
Synonym: azotemia
Tree Number: T3.6.18.6
database_cross_reference: CCPSS:1001585
database_cross_reference: CHV:0000024863
database_cross_reference: COSTAR:091
database_cross_reference: CSP:1682-3281
database_cross_reference: CST:NPN INC
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0002157
database_cross_reference: LCH:U006263
database_cross_reference: LCH_NW:sh85010664
database_cross_reference: MDR:10003885
database_cross_reference: MDR:10003886
database_cross_reference: MSH:D053099
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000181077
database_cross_reference: OMIM:MTHU013356
database_cross_reference: SNM:F-10463
database_cross_reference: SNMI:D7-11028
database_cross_reference: SNOMEDCT_US:445009001
database_cross_reference: SNOMEDCT_VET:282151000009107

Pseudobulbar signs
type: Class
subclass of: Abnormality of nervous system physiology
definition: Pseudobulbar signs result from injury to an upper motor neuron lesion to the corticobulbar pathways in the pyramidal tract. Patients have difficulty chewing, swallowing and demonstrate slurred speech (often initial presentation) as well as abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc.
PMOID: PMO:00011261
Subclass_of: Abnormality of nervous system physiology
Synonym: Pseudobulbar symptoms
Tree Number: T3.18.3.21
database_cross_reference: HPO:HP:0002200
database_cross_reference: OMIM:MTHU006592
database_cross_reference: OMIM:MTHU031656

Abnormality of the autonomic nervous system
type: Class
subclass of: Abnormality of the peripheral nervous system
definition: An abnormality of the autonomic nervous system.
PMOID: PMO:00011336
Subclass_of: Abnormality of the peripheral nervous system
Tree Number: T3.18.4.1
database_cross_reference: HPO:HP:0002270

Headache
type: Class
subclass of: Abnormality of nervous system physiology
definition: Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
PMOID: PMO:00011213
Subclass_of: Abnormality of nervous system physiology
Synonym: CEPHALALGIA
Synonym: CEPHALGIA
Synonym: Cephalalgia
Synonym: Cephalalgias
Synonym: Cephalgia
Synonym: Cephalgias
Synonym: Cephalodynia
Synonym: Cephalodynias
Synonym: Cranial Pain
Synonym: Cranial Pains
Tree Number: T3.18.3.18
database_cross_reference: AOD:0000006115
database_cross_reference: AOD:0000006116
database_cross_reference: AOD:0000006117
database_cross_reference: BI:BI00020
database_cross_reference: CCPSS:1014497
database_cross_reference: CCPSS:U001223
database_cross_reference: CHV:0000005820
database_cross_reference: COSTAR:343
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2056-6161
database_cross_reference: CST:HEADACHE
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001858
database_cross_reference: HPO:HP:0002315
database_cross_reference: ICD10:R51
database_cross_reference: ICD10AM:R51
database_cross_reference: ICD10CM:R51
database_cross_reference: ICD9CM:784.0
database_cross_reference: ICPC2EENG:N01
database_cross_reference: ICPC2P:N01001
database_cross_reference: ICPC2P:N01004
database_cross_reference: LCH:U002088
database_cross_reference: LCH_NW:sh85059488
database_cross_reference: LNC:LA15854-5
database_cross_reference: LNC:LA15903-0
database_cross_reference: LNC:LP217220-5
database_cross_reference: LNC:MTHU020860
database_cross_reference: LNC:MTHU053651
database_cross_reference: MDR:10008011
database_cross_reference: MDR:10008013
database_cross_reference: MDR:10019198
database_cross_reference: MDR:10019211
database_cross_reference: MDR:10019218
database_cross_reference: MDR:10019231
database_cross_reference: MDR:10033405
database_cross_reference: MEDCIN:10
database_cross_reference: MEDLINEPLUS:273
database_cross_reference: MSH:D006261
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:784.0
database_cross_reference: NCI:C34661
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CTCAE:E12678
database_cross_reference: NCI_FDA:1880
database_cross_reference: NCI_NICHD:C34661
database_cross_reference: NDFRT:N0000001418
database_cross_reference: OMIM:MTHU036348
database_cross_reference: OMIM:MTHU036635
database_cross_reference: PSY:22380
database_cross_reference: RCD:R040.
database_cross_reference: RCD:XE0rh
database_cross_reference: RCD:XE2rs
database_cross_reference: RCDSY:R040.
database_cross_reference: RCDSY:XE2rs
database_cross_reference: SNM:F-82700
database_cross_reference: SNMI:F-A2700
database_cross_reference: SNOMEDCT_US:139490008
database_cross_reference: SNOMEDCT_US:158296002
database_cross_reference: SNOMEDCT_US:158298001
database_cross_reference: SNOMEDCT_US:162209005
database_cross_reference: SNOMEDCT_US:206946005
database_cross_reference: SNOMEDCT_US:206948006
database_cross_reference: SNOMEDCT_US:25064002

Bulbar signs
type: Class
subclass of: Abnormality of nervous system physiology
PMOID: PMO:00011191
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.13
database_cross_reference: HPO:HP:0002483

Myotonia
type: Class
subclass of: Abnormality of muscle physiology
definition: An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation.
PMOID: PMO:00009658
Subclass_of: Abnormality of muscle physiology
Synonym: Delayed relaxation of muscle fibers after contraction
Tree Number: T3.17.3.9
database_cross_reference: HPO:HP:0002486

Areflexia of lower limbs
type: Class
subclass of: Abnormality of the lower limb
definition: Inability to elicit tendon reflexes in the lower limbs.
PMOID: PMO:00002821
Subclass_of: Abnormality of the lower limb
Synonym: Absent lower limb tendon reflexes
Synonym: Areflexia in lower limbs
Synonym: Areflexia of the lower limbs
Synonym: Areflexia, lower limbs
Tree Number: T3.5.2.7
database_cross_reference: HPO:HP:0002522

Cataplexy
type: Class
subclass of: Abnormality of nervous system physiology
definition: A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions.
PMOID: PMO:00011192
Subclass_of: Abnormality of nervous system physiology
Synonym: Attack, Cataleptic
Synonym: Attacks, Cataleptic
Synonym: CATAPLEXY
Synonym: Cataleptic Attack
Synonym: Cataleptic Attacks
Synonym: Cataplexy (diagnosis)
Synonym: Cataplexy (disorder)
Synonym: Cataplexy [Disease/Finding]
Synonym: Henneberg Syndrome
Synonym: Syndrome, Henneberg
Tree Number: T3.18.3.14
database_cross_reference: CCPSS:1002072
database_cross_reference: CHV:0000002517
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3270
database_cross_reference: CST:CONVULS
database_cross_reference: DXP:U000304
database_cross_reference: DXP:U000571
database_cross_reference: HPO:HP:0002524
database_cross_reference: MDR:10007737
database_cross_reference: MEDCIN:359464
database_cross_reference: MSH:D002385
database_cross_reference: NCI:C84618
database_cross_reference: NDFRT:N0000000697
database_cross_reference: OMIM:161400
database_cross_reference: OMIM:MTHU003011
database_cross_reference: PSY:07880
database_cross_reference: RCD:F270.
database_cross_reference: SNM:F-85770
database_cross_reference: SNMI:D9-74260
database_cross_reference: SNOMEDCT_US:46263000

Abnormality of the peritoneum
type: Class
subclass of: Abnormality of the abdominal organs
definition: An abnormality of the peritoneum.
PMOID: PMO:00005533
Subclass_of: Abnormality of the abdominal organs
Tree Number: T3.10.4.4
database_cross_reference: HPO:HP:0002585

Abnormality of the vasculature
type: Class
subclass of: Abnormality of the cardiovascular system
definition: An abnormality of the vasculature.
PMOID: PMO:00004970
Subclass_of: Abnormality of the cardiovascular system
Synonym: Abnormality of blood vessels
Synonym: Vascular abnormalities
Tree Number: T3.9.5
database_cross_reference: HPO:HP:0002597

Peripheral thrombosis
type: Class
subclass of: Abnormal thrombosis
PMOID: PMO:00001108
Subclass_of: Abnormal thrombosis
Synonym: Peripheral blood clot
Tree Number: T3.2.6.3
database_cross_reference: HPO:HP:0002641
database_cross_reference: OMIM:MTHU010059

Skeletal dysplasia
type: Class
subclass of: Abnormality of skeletal morphology
definition: A general term describing features characterized by abnormal development of bones and connective tissues.
PMOID: PMO:00013956
Subclass_of: Abnormality of skeletal morphology
Synonym: 4-00A OSTEOCHONDRODYSPLASIA SYNDROMES
Synonym: Congenital Skeletal Dysplasia
Synonym: OSTEOCHONDRODYSPLASIA SYNDROMES
Synonym: Osteochondrodysplasia
Synonym: Osteochondrodysplasia (disorder)
Synonym: Osteochondrodysplasia syndrome
Synonym: Osteochondrodysplasia syndrome (disorder)
Synonym: Osteochondrodysplasia, NOS
Synonym: Osteochondrodysplasia, unspecified
Synonym: Osteochondrodysplasias
Tree Number: T3.20.1.14
database_cross_reference: HPO:HP:0002652
database_cross_reference: ICD10:Q78.9
database_cross_reference: ICD10AM:Q78.9
database_cross_reference: ICD10CM:Q78.9
database_cross_reference: MEDCIN:330547
database_cross_reference: MSH:D010009
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84978
database_cross_reference: NCI_NICHD:C84978
database_cross_reference: NDFRT:N0000002249
database_cross_reference: OMIM:MTHU041797
database_cross_reference: RCD:X70Bq
database_cross_reference: SNM:M-74500
database_cross_reference: SNM:U000377
database_cross_reference: SNMI:D4-00A00
database_cross_reference: SNMI:D6-70240
database_cross_reference: SNOMEDCT_US:105985007
database_cross_reference: SNOMEDCT_US:205510001
database_cross_reference: SNOMEDCT_US:240190009
database_cross_reference: SNOMEDCT_US:378007

Bone pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.
PMOID: PMO:00014086
Subclass_of: Pain
Synonym: BONE PAIN
Synonym: Bone Pain
Synonym: Bone pain (diffuse not joint pain or arthritis)
Synonym: Bone pain (finding)
Synonym: OSTALGIA
Synonym: Ostealgia
Synonym: Osteodynia
Synonym: PAIN BONE
Synonym: Pain bone
Synonym: Pain;bone
Tree Number: T3.23.10.7
database_cross_reference: CCPSS:0024284
database_cross_reference: CCPSS:1001749
database_cross_reference: CHV:0000017079
database_cross_reference: COSTAR:U000084
database_cross_reference: CST:PAIN
database_cross_reference: CST:PAIN BONE
database_cross_reference: DXP:U000423
database_cross_reference: HPO:HP:0002653
database_cross_reference: ICPC2P:L29004
database_cross_reference: LNC:MTHU020858
database_cross_reference: MDR:10006002
database_cross_reference: MDR:10033384
database_cross_reference: MDR:10040777
database_cross_reference: MDR:10070685
database_cross_reference: MDR:10076740
database_cross_reference: MEDCIN:991
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38644
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CTCAE:E12392
database_cross_reference: OMIM:MTHU005592
database_cross_reference: RCD:X75rq
database_cross_reference: SNMI:F-12600
database_cross_reference: SNOMEDCT_US:12584003
database_cross_reference: SNOMEDCT_US:203507006

Increased susceptibility to fractures
type: Class
subclass of: Abnormality of skeletal physiology
definition: An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture.
PMOID: PMO:00013981
Subclass_of: Abnormality of skeletal physiology
Synonym: Abnormal susceptibility to fractures
Synonym: Bone fragility
Synonym: Frequent broken bones
Synonym: Increased bone fragility
Synonym: Increased tendency to fractures
Tree Number: T3.20.2.3
database_cross_reference: HPO:HP:0002659

Neoplasm
type: Class
subclass of: Phenotypic Abnormality
definition: An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumour).
PMOID: PMO:00014191
Subclass_of: Phenotypic Abnormality
Synonym: 800 NEOPLASMS, NOS
Synonym: NEOPL
Synonym: NEOPLASIA
Synonym: NEOPLASM
Synonym: NEOPLASM (NOS)
Synonym: NEOPLASM NOS
Synonym: NEOPLASMS
Synonym: NEOPLASMS, NOS
Synonym: NG - Neoplastic growth
Synonym: NG - New growth
Tree Number: T3.25
database_cross_reference: AOD:0000004514
database_cross_reference: AOD:0000004515
database_cross_reference: AOD:0000007366
database_cross_reference: AOD:0000023007
database_cross_reference: CCPSS:1010221
database_cross_reference: CCPSS:1013404
database_cross_reference: CHV:0000008566
database_cross_reference: COSTAR:755
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2000-0173
database_cross_reference: CSP:2029-2915
database_cross_reference: CST:NEOPL
database_cross_reference: HPO:HP:0002664
database_cross_reference: ICD10:C00-D48.9
database_cross_reference: ICD10AM:C00-D48.9
database_cross_reference: ICD10CM:D49
database_cross_reference: ICD9CM:140-239.99
database_cross_reference: ICPC2P:A79002
database_cross_reference: LCH:U005814
database_cross_reference: LCH_NW:sh85138553
database_cross_reference: LNC:LA16304-0
database_cross_reference: LNC:LP207120-9
database_cross_reference: LNC:LP7664-8
database_cross_reference: LNC:MTHU010346
database_cross_reference: MDR:10028980
database_cross_reference: MDR:10029000
database_cross_reference: MDR:10029104
database_cross_reference: MDR:10048524
database_cross_reference: MEDCIN:363344
database_cross_reference: MEDLINEPLUS:25
database_cross_reference: MSH:D009369
database_cross_reference: MTH:471
database_cross_reference: MTH:755
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3262
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000045801
database_cross_reference: NCI_NCI-GLOSS:CDR0000046264
database_cross_reference: NCI_NCI-GLOSS:CDR0000046634
database_cross_reference: NCI_NICHD:C3262
database_cross_reference: NDFRT:N0000002128
database_cross_reference: OMIM:MTHU000126
database_cross_reference: PSY:33370
database_cross_reference: PSY:54430
database_cross_reference: RCD:BB0..
database_cross_reference: RCD:Bz...
database_cross_reference: RCD:XE1vN
database_cross_reference: RCDAE:Bz...
database_cross_reference: RCDAE:XE1vN
database_cross_reference: RCDSY:BB0..
database_cross_reference: SNM:M-8000/1
database_cross_reference: SNM:U000390
database_cross_reference: SNMI:M-80000
database_cross_reference: SNMI:M-80001
database_cross_reference: SNOMEDCT_US:108369006
database_cross_reference: SNOMEDCT_US:154634001
database_cross_reference: SNOMEDCT_US:154645003
database_cross_reference: SNOMEDCT_US:154646002
database_cross_reference: SNOMEDCT_US:187597000
database_cross_reference: SNOMEDCT_US:189542002
database_cross_reference: SNOMEDCT_US:190230000
database_cross_reference: SNOMEDCT_US:86251006

Lymphoma
type: Class
subclass of: Hematological neoplasm
definition: A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells.
PMOID: PMO:00001238
Subclass_of: Hematological neoplasm
Synonym: Germinoblastic Sarcoma
Synonym: Germinoblastic Sarcomas
Synonym: Germinoblastic sarcoma
Synonym: Germinoblastoma
Synonym: Germinoblastomas
Synonym: LYMPHOMA
Synonym: LYMPHOMA MALIGNANT
Synonym: LYMPHOMA, MALIGNANT
Synonym: Lymphoma (Hodgkin and Non-Hodgkin)
Synonym: Lymphoma (Hodgkin's and Non-Hodgkin's)
Tree Number: T3.2.10.2
database_cross_reference: AOD:0000004624
database_cross_reference: BI:BI00323
database_cross_reference: CCPSS:1017994
database_cross_reference: CHV:0000007617
database_cross_reference: COSTAR:462
database_cross_reference: CSP:2004-6589
database_cross_reference: CST:LYMPHOMA LIKE REACT
database_cross_reference: DO:DOID:0060058
database_cross_reference: DXP:U002475
database_cross_reference: HPO:HP:0002665
database_cross_reference: ICD10AM:M9590/3
database_cross_reference: ICD10CM:C85.9
database_cross_reference: ICPC2P:B72002
database_cross_reference: LCH:U002766
database_cross_reference: LCH_NW:sh85079154
database_cross_reference: LNC:LA15685-3
database_cross_reference: MDR:10025310
database_cross_reference: MDR:10025315
database_cross_reference: MDR:10025316
database_cross_reference: MDR:10025632
database_cross_reference: MDR:10025633
database_cross_reference: MEDCIN:36081
database_cross_reference: MEDLINEPLUS:117
database_cross_reference: MSH:D008223
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:200.8
database_cross_reference: MTHICD9:202.8
database_cross_reference: NCI:C3208
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3208
database_cross_reference: NCI_CTEP-SDC:10025316
database_cross_reference: NCI_FDA:3263
database_cross_reference: NCI_NCI-GLOSS:CDR0000045368
database_cross_reference: NCI_NICHD:C3208
database_cross_reference: NDFRT:N0000001905
database_cross_reference: OMIM:MTHU007429
database_cross_reference: PDQ:CDR0000041429
database_cross_reference: RCD:B62y.
database_cross_reference: RCD:B62y0
database_cross_reference: RCD:BBg1.
database_cross_reference: RCD:X77q5
database_cross_reference: RCD:Xa99k
database_cross_reference: RCDSY:BBg1.
database_cross_reference: SNM:M-9590/3
database_cross_reference: SNM:M-9613/3
database_cross_reference: SNM:M-9632/3
database_cross_reference: SNMI:M-95903
database_cross_reference: SNOMEDCT_US:115244002
database_cross_reference: SNOMEDCT_US:118600007
database_cross_reference: SNOMEDCT_US:134218000
database_cross_reference: SNOMEDCT_US:188676008
database_cross_reference: SNOMEDCT_US:188694002
database_cross_reference: SNOMEDCT_US:188695001
database_cross_reference: SNOMEDCT_US:188704004
database_cross_reference: SNOMEDCT_US:189959002
database_cross_reference: SNOMEDCT_US:189965002
database_cross_reference: SNOMEDCT_US:21964009
database_cross_reference: SNOMEDCT_US:269627002
database_cross_reference: SNOMEDCT_VET:118600007

Prenatal maternal abnormality
type: Class
subclass of: Abnormality of prenatal development or birth
PMOID: PMO:00004383
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.11
database_cross_reference: HPO:HP:0002686

Abnormality of the immune system
type: Class
subclass of: Phenotypic Abnormality
definition: An abnormality of the immune system.
PMOID: PMO:00008249
Subclass_of: Phenotypic Abnormality
Synonym: Immunological abnormality
Tree Number: T3.15
database_cross_reference: HPO:HP:0002715

Recurrent infections
type: Class
subclass of: Abnormality of immune system physiology
definition: Increased susceptibility to infections.
PMOID: PMO:00008637
Subclass_of: Abnormality of immune system physiology
Synonym: Frequent infections
Synonym: Frequent, severe infections
Synonym: Increased frequency of infection
Synonym: Predisposition to infections
Synonym: Susceptibility to infection
Synonym: infections, recurrent
Tree Number: T3.15.2.14
database_cross_reference: HPO:HP:0002719

Immunodeficiency
type: Class
subclass of: Abnormality of immune system physiology
definition: Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.
PMOID: PMO:00008602
Subclass_of: Abnormality of immune system physiology
Synonym: DEFIC SYNDROME IMMUNOL
Synonym: DEFIC SYNDROMES IMMUNOL
Synonym: Decreased immune function
Synonym: Deficiency Syndrome, Immunologic
Synonym: Deficiency Syndrome, Immunological
Synonym: Deficiency Syndromes, Immunologic
Synonym: Deficiency Syndromes, Immunological
Synonym: Deficiency;immune
Synonym: IMMUNODEFICIENCY
Synonym: IMMUNOL DEFIC SYNDROME
Tree Number: T3.15.2.10
database_cross_reference: AOD:0000004832
database_cross_reference: CCPSS:1007151
database_cross_reference: CHV:0000006602
database_cross_reference: CHV:0000049889
database_cross_reference: COSTAR:U000355
database_cross_reference: CSP:1553-9570
database_cross_reference: CSP:1560-5885
database_cross_reference: DO:DOID:612
database_cross_reference: HPO:HP:0002721
database_cross_reference: ICD10:D84.9
database_cross_reference: ICD10AM:D84.9
database_cross_reference: ICD10CM:D84.9
database_cross_reference: ICD9CM:279.3
database_cross_reference: ICPC2P:B99011
database_cross_reference: LCH_NW:sh85064574
database_cross_reference: LNC:LP231628-1
database_cross_reference: LNC:MTHU054768
database_cross_reference: MDR:10021451
database_cross_reference: MDR:10021460
database_cross_reference: MDR:10045922
database_cross_reference: MDR:10061598
database_cross_reference: MEDCIN:39922
database_cross_reference: MSH:D007153
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3131
database_cross_reference: NCI:C39725
database_cross_reference: NCI_FDA:2156
database_cross_reference: NCI_NCI-GLOSS:CDR0000045724
database_cross_reference: NCI_NCI-GLOSS:CDR0000046357
database_cross_reference: NCI_NICHD:C39725
database_cross_reference: NDFRT:N0000001667
database_cross_reference: OMIM:MTHU007447
database_cross_reference: OMIM:MTHU032911
database_cross_reference: RCD:C393.
database_cross_reference: RCD:X20GZ
database_cross_reference: SNM:D-4600
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:F-C0450
database_cross_reference: SNOMEDCT_US:191005003
database_cross_reference: SNOMEDCT_US:234532001
database_cross_reference: SNOMEDCT_US:64431000
database_cross_reference: SNOMEDCT_VET:234532001

Abnormality of the lymph nodes
type: Class
subclass of: Abnormality of the lymphatic system
definition: A lymph node abnormality.
PMOID: PMO:00008688
Subclass_of: Abnormality of the lymphatic system
Synonym: Abnormal lymph node histology
Tree Number: T3.15.3.2
database_cross_reference: HPO:HP:0002733

Osteomyelitis
type: Class
subclass of: Abnormality of skeletal physiology
definition: Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism.
PMOID: PMO:00013987
Subclass_of: Abnormality of skeletal physiology
Synonym: OM - Osteomyelitis
Synonym: OSTEOMYELITIS
Synonym: OSTM - Osteomyelitis
Synonym: Osteomyelitides
Synonym: Osteomyelitis (disorder)
Synonym: Osteomyelitis NOS
Synonym: Osteomyelitis NOS-unspec
Synonym: Osteomyelitis [Ambiguous]
Synonym: Osteomyelitis [Disease/Finding]
Synonym: Osteomyelitis, NOS
Tree Number: T3.20.2.4
database_cross_reference: AOD:0000005153
database_cross_reference: BI:BI00508
database_cross_reference: CCPSS:1018040
database_cross_reference: CHV:0000009088
database_cross_reference: COSTAR:539
database_cross_reference: CSP:2715-2811
database_cross_reference: CST:OSTEOMYELITIS
database_cross_reference: DXP:U002943
database_cross_reference: HPO:HP:0002754
database_cross_reference: ICD10:M86
database_cross_reference: ICD10:M86.9
database_cross_reference: ICD10AM:M86
database_cross_reference: ICD10AM:M86.9
database_cross_reference: ICD10AM:M86.99
database_cross_reference: ICD10CM:M86
database_cross_reference: ICD10CM:M86.9
database_cross_reference: ICD9CM:730.2
database_cross_reference: ICD9CM:730.20
database_cross_reference: ICPC2P:L70014
database_cross_reference: LCH:U003403
database_cross_reference: LCH_NW:sh85095971
database_cross_reference: LNC:LP128775-6
database_cross_reference: LNC:MTHU040697
database_cross_reference: MDR:10031252
database_cross_reference: MDR:10031259
database_cross_reference: MDR:10046076
database_cross_reference: MDR:10046086
database_cross_reference: MEDCIN:31232
database_cross_reference: MEDLINEPLUS:5739
database_cross_reference: MSH:D010019
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C27577
database_cross_reference: NCI_NCI-GLOSS:CDR0000471782
database_cross_reference: NCI_NICHD:C27577
database_cross_reference: NDFRT:N0000002256
database_cross_reference: OMIM:MTHU037798
database_cross_reference: RCD:N3020
database_cross_reference: RCD:N302z
database_cross_reference: RCD:X70AW
database_cross_reference: RCD:XE1Fz
database_cross_reference: SNM:M-40000
database_cross_reference: SNMI:D1-60210
database_cross_reference: SNOMEDCT_US:156801003
database_cross_reference: SNOMEDCT_US:156810006
database_cross_reference: SNOMEDCT_US:203206001
database_cross_reference: SNOMEDCT_US:203207005
database_cross_reference: SNOMEDCT_US:203244005
database_cross_reference: SNOMEDCT_US:240141009
database_cross_reference: SNOMEDCT_US:268020008
database_cross_reference: SNOMEDCT_US:60168000

Abnormal cartilage morphology
type: Class
subclass of: Abnormality of skeletal morphology
definition: Any morphological abnormality of cartilage.
PMOID: PMO:00013808
Subclass_of: Abnormality of skeletal morphology
Synonym: Abnormal shape of cartilage
Tree Number: T3.20.1.4
database_cross_reference: HPO:HP:0002763

Upper airway obstruction
type: Class
subclass of: Functional respiratory abnormality
definition: Increased resistance to the passage of air in the upper airway.
PMOID: PMO:00011668
Subclass_of: Functional respiratory abnormality
Synonym: AIRWAY OBSTRUCTION UPPER
Synonym: airway obstruction upper
Synonym: airway obstructions upper
Synonym: upper airway obstruction
Tree Number: T3.19.2.24
database_cross_reference: CCPSS:0018730
database_cross_reference: CHV:0000047182
database_cross_reference: HPO:HP:0002781
database_cross_reference: MDR:10067775
database_cross_reference: OMIM:MTHU014450

Tracheal calcification
type: Class
subclass of: Ectopic calcification
definition: Calcification (abnormal deposits of calcium) in the tracheal tissues.
PMOID: PMO:00014014
Subclass_of: Ectopic calcification
Synonym: Calcification of the trachea
Synonym: Calcification of trachea
Synonym: Calcification of trachea (disorder)
Synonym: Trachea calcifications
Synonym: Tracheal Calcification
Synonym: Tracheal calcifications
Synonym: Tracheal ectopic calcification
Synonym: tracheal calcification
Synonym: tracheal calcification (diagnosis)
Tree Number: T3.20.4.10
database_cross_reference: DO:DOID:14224
database_cross_reference: HPO:HP:0002787
database_cross_reference: MDR:10051880
database_cross_reference: MEDCIN:275993
database_cross_reference: NCI:C35314
database_cross_reference: OMIM:MTHU007984
database_cross_reference: OMIM:MTHU020582
database_cross_reference: RCD:H5y10
database_cross_reference: SNMI:D2-10310
database_cross_reference: SNOMEDCT_US:81089005

Reduced vital capacity
type: Class
subclass of: Functional respiratory abnormality
definition: An abnormal reduction on the vital capacity, which is defined as the total lung capacity (volume of air in the lungs at maximal inflation) less the residual volume (i.e., volume of air in the lungs following maximal exhalation) of the lung.
PMOID: PMO:00011649
Subclass_of: Functional respiratory abnormality
Synonym: Decreased vital capacity
Tree Number: T3.19.2.19
database_cross_reference: HPO:HP:0002792

Abnormal pattern of respiration
type: Class
subclass of: Functional respiratory abnormality
definition: An anomaly of the rhythm or depth of breathing.
PMOID: PMO:00011580
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal respiratory patterns
Synonym: Unusual breathing patterns
Tree Number: T3.19.2.6
database_cross_reference: HPO:HP:0002793

Functional respiratory abnormality
type: Class
subclass of: Abnormality of the respiratory system
PMOID: PMO:00011552
Subclass_of: Abnormality of the respiratory system
Synonym: Abnormal respiration
Tree Number: T3.19.2
database_cross_reference: HPO:HP:0002795

Congenital contracture
type: Class
subclass of: Flexion contracture
definition: One or more flexion contractures (a bent joint that cannot be straightened actively or passively) that are present at birth.
PMOID: PMO:00001312
Subclass_of: Flexion contracture
Synonym: Congenital contracture (morphologic abnormality)
Synonym: Congenital contracture, NOS
Synonym: Congenital contractures
Synonym: Congenital joint contractures
Synonym: Contracture, congenital
Synonym: Contractures, congenital
Synonym: congenital contractures
Tree Number: T3.3.6.1
database_cross_reference: HPO:HP:0002803
database_cross_reference: OMIM:MTHU003115
database_cross_reference: OMIM:MTHU011748
database_cross_reference: OMIM:MTHU056249
database_cross_reference: SNM:M-22640
database_cross_reference: SNMI:M-20140
database_cross_reference: SNOMEDCT_US:91287001

Abnormality of the lower limb
type: Class
subclass of: Abnormality of limbs
definition: An abnormality of the leg.
PMOID: PMO:00002520
Subclass_of: Abnormality of limbs
Synonym: Abnormality of the leg
Synonym: Deformity of lower limb
Synonym: Deformity of lower limb (finding)
Synonym: EXTREMITY DEFORMITY, LOWER
Synonym: Hindlimb deformity
Synonym: LOWER EXTREMITY DEFORMITY
Synonym: Lower limb deformities
Synonym: Lower limb deformity
Tree Number: T3.5.2
database_cross_reference: CCPSS:0041695
database_cross_reference: DXP:U001221
database_cross_reference: HPO:HP:0002814
database_cross_reference: MDR:10053640
database_cross_reference: OMIM:MTHU006324
database_cross_reference: SNOMEDCT_US:449715001
database_cross_reference: SNOMEDCT_VET:310581000009104
database_cross_reference: SNOMEDCT_VET:449715001

Abnormality of the upper limb
type: Class
subclass of: Abnormality of limbs
definition: An abnormality of the arm.
PMOID: PMO:00002860
Subclass_of: Abnormality of limbs
Synonym: Abnormality of the arm
Tree Number: T3.5.4
database_cross_reference: HPO:HP:0002817

Multiple joint contractures
type: Class
subclass of: Flexion contracture
PMOID: PMO:00001346
Subclass_of: Flexion contracture
Synonym: Contracture of joint of multiple sites
Synonym: Contracture of joint of multiple sites (disorder)
Synonym: Contracture of joint, multiple sites
Synonym: Contracture of multiple joints
Synonym: Contracture of multiple joints (disorder)
Synonym: Jt contracture-mult jts
Synonym: contracture of multiple sites
Synonym: contracture of multiple sites (diagnosis)
Tree Number: T3.3.6.7
database_cross_reference: HPO:HP:0002828
database_cross_reference: ICD10AM:M24.50
database_cross_reference: ICD9CM:718.49
database_cross_reference: MDR:10010823
database_cross_reference: MEDCIN:94087
database_cross_reference: OMIM:MTHU004616
database_cross_reference: RCD:N0849
database_cross_reference: SNMI:D1-2237A
database_cross_reference: SNOMEDCT_US:156548005
database_cross_reference: SNOMEDCT_US:19393004
database_cross_reference: SNOMEDCT_US:202264009

Arthralgia
type: Class
subclass of: Pain
definition: Joint pain.
PMOID: PMO:00014081
Subclass_of: Pain
Synonym: ARTHRALGIA
Synonym: ARTHRALGIAS
Synonym: Ache in joint
Synonym: Aching joints
Synonym: Arthralgia NOS
Synonym: Arthralgia NOS (finding)
Synonym: Arthralgia [Disease/Finding]
Synonym: Arthralgias
Synonym: Arthritic-like pain
Synonym: Arthrodynia
Tree Number: T3.23.10.5
database_cross_reference: AOD:0000005081
database_cross_reference: BI:BI00473
database_cross_reference: CCPSS:1015794
database_cross_reference: CHV:0000001465
database_cross_reference: COSTAR:072
database_cross_reference: COSTAR:U000004
database_cross_reference: COSTAR:U000033
database_cross_reference: COSTAR:U000034
database_cross_reference: CST:ARTHRALGIA
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000253
database_cross_reference: HPO:HP:0002829
database_cross_reference: ICD10:M25.5
database_cross_reference: ICD10AM:M25.5
database_cross_reference: ICD10AM:M25.59
database_cross_reference: ICD10CM:M25.5
database_cross_reference: ICD9CM:719.4
database_cross_reference: ICD9CM:719.40
database_cross_reference: ICPC2P:L20001
database_cross_reference: ICPC2P:L20005
database_cross_reference: LNC:MTHU013526
database_cross_reference: LNC:MTHU020863
database_cross_reference: MDR:10000449
database_cross_reference: MDR:10003239
database_cross_reference: MDR:10003245
database_cross_reference: MDR:10013088
database_cross_reference: MDR:10023197
database_cross_reference: MDR:10023222
database_cross_reference: MDR:10033434
database_cross_reference: MDR:10033444
database_cross_reference: MDR:10033456
database_cross_reference: MDR:10033511
database_cross_reference: MEDCIN:315545
database_cross_reference: MEDCIN:954
database_cross_reference: MSH:D018771
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:719.4
database_cross_reference: NCI:C50464
database_cross_reference: NCI_CTCAE:E12374
database_cross_reference: NCI_FDA:2355
database_cross_reference: NCI_NCI-GLOSS:CDR0000455150
database_cross_reference: NCI_NICHD:C50464
database_cross_reference: NDFRT:N0000003851
database_cross_reference: OMIM:MTHU000202
database_cross_reference: OMIM:MTHU002712
database_cross_reference: OMIM:MTHU011701
database_cross_reference: OMIM:MTHU013843
database_cross_reference: OMIM:MTHU017185
database_cross_reference: RCD:N094z
database_cross_reference: RCD:XE1EY
database_cross_reference: SNM:F-82600
database_cross_reference: SNMI:F-13100
database_cross_reference: SNOMEDCT_US:156592007
database_cross_reference: SNOMEDCT_US:156602008
database_cross_reference: SNOMEDCT_US:202467004
database_cross_reference: SNOMEDCT_US:202499005
database_cross_reference: SNOMEDCT_US:268065004
database_cross_reference: SNOMEDCT_US:57676002

Calcific stippling
type: Class
subclass of: Ectopic calcification
definition: An abnormal punctate (speckled, dot-like) pattern of calcifications in soft tissues within or surrounding bones (as observed on radiographs).
PMOID: PMO:00013999
Subclass_of: Ectopic calcification
Synonym: Discrete calcific stippling
Tree Number: T3.20.4.1
database_cross_reference: HPO:HP:0002832

Aspiration
type: Class
subclass of: Functional respiratory abnormality
definition: Inspiration of a foreign object into the airway.
PMOID: PMO:00011623
Subclass_of: Functional respiratory abnormality
Synonym: 292 PULMONARY ASPIRATION
Synonym: ASPIRATION
Synonym: Aspirated
Synonym: Aspiration, NOS
Synonym: PULMONARY ASPIRATION
Synonym: Pulmonary Aspirations
Synonym: Pulmonary aspiration
Synonym: Pulmonary aspiration (diagnosis)
Synonym: Pulmonary aspiration (finding)
Synonym: Pulmonary aspiration, NOS
Tree Number: T3.19.2.11
database_cross_reference: CCPSS:0023485
database_cross_reference: CHV:0000022853
database_cross_reference: CHV:0000044687
database_cross_reference: CST:RESPIRAT DIS
database_cross_reference: DXP:U000268
database_cross_reference: HPO:HP:0002835
database_cross_reference: MDR:10003504
database_cross_reference: MEDCIN:361189
database_cross_reference: MEDCIN:91253
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:F-79000
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:F-29200
database_cross_reference: SNOMEDCT_US:68052005

Melanoma
type: Class
subclass of: Neoplasm by histology
definition: The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea).
PMOID: PMO:00014326
Subclass_of: Neoplasm by histology
Synonym: Cutaneous melanoma
Synonym: MALIGNANT MELANOMA
Synonym: MELANOMA
Synonym: MELANOMA MALIGNANT
Synonym: MELANOMA, MALIGNANT
Synonym: MM - Malignant melanoma
Synonym: Malignant Melanoma
Synonym: Malignant Melanomas
Synonym: Malignant melanoma
Synonym: Malignant melanoma (disorder)
Tree Number: T3.25.2.5
database_cross_reference: AOD:0000004558
database_cross_reference: BI:BI00601
database_cross_reference: CHV:0000007894
database_cross_reference: COSTAR:467
database_cross_reference: COSTAR:475
database_cross_reference: CSP:2020-2434
database_cross_reference: CST:MELANOMA SKIN
database_cross_reference: DO:DOID:1909
database_cross_reference: DO:DOID:8923
database_cross_reference: DXP:U001151
database_cross_reference: HPO:HP:0002861
database_cross_reference: HPO:HP:0012056
database_cross_reference: ICD10AM:M8720/3
database_cross_reference: ICPC2P:S77003
database_cross_reference: LCH:U002889
database_cross_reference: LCH_NW:sh85083381
database_cross_reference: LNC:LA14279-6
database_cross_reference: MDR:10025650
database_cross_reference: MDR:10027150
database_cross_reference: MDR:10053571
database_cross_reference: MEDCIN:352914
database_cross_reference: MEDLINEPLUS:321
database_cross_reference: MSH:D008545
database_cross_reference: MTH:475
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3224
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3224
database_cross_reference: NCI_CTEP-SDC:10053571
database_cross_reference: NCI_NCI-GLOSS:CDR0000045135
database_cross_reference: NCI_NICHD:C3224
database_cross_reference: NDFRT:N0000001969
database_cross_reference: OMIM:MTHU000127
database_cross_reference: OMIM:MTHU001388
database_cross_reference: PDQ:CDR0000038833
database_cross_reference: RCD:XE1wX
database_cross_reference: RCD:Xa99S
database_cross_reference: RCDSY:XE1wX
database_cross_reference: SNM:D-2946
database_cross_reference: SNM:M-8720/3
database_cross_reference: SNMI:M-87203
database_cross_reference: SNOMEDCT_US:154501005
database_cross_reference: SNOMEDCT_US:189749008
database_cross_reference: SNOMEDCT_US:2092003
database_cross_reference: SNOMEDCT_US:269503007
database_cross_reference: SNOMEDCT_US:269577007
database_cross_reference: SNOMEDCT_US:372244006
database_cross_reference: SNOMEDCT_VET:309331000009104

Myelodysplasia
type: Class
subclass of: Hematological neoplasm
definition: Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.
PMOID: PMO:00001253
Subclass_of: Hematological neoplasm
Synonym: 998 MYELODYSPLASTIC SYNDROME
Synonym: Dysmyelopoietic Syndrome
Synonym: Dysmyelopoietic Syndromes
Synonym: Dysmyelopoietic syndrome
Synonym: Hematopoeitic - Myelodysplastic Syndrome (MDS)
Synonym: MDS
Synonym: MDS - Myelodysplastic syndrome
Synonym: MYELODYSPLASTIC SYNDROME
Synonym: MYELODYSPLASTIC SYNDROME, SUSCEPTIBILITY TO
Synonym: Myelodysplasia (disorder)
Tree Number: T3.2.10.6
database_cross_reference: CCPSS:0045936
database_cross_reference: CHV:0000008407
database_cross_reference: CHV:0000010081
database_cross_reference: COSTAR:U000455
database_cross_reference: DXP:U001579
database_cross_reference: HPO:HP:0002863
database_cross_reference: ICD10:D46
database_cross_reference: ICD10:D46.9
database_cross_reference: ICD10AM:D46
database_cross_reference: ICD10AM:D46.9
database_cross_reference: ICD10AM:M9989/1
database_cross_reference: ICD10CM:D46
database_cross_reference: ICD10CM:D46.9
database_cross_reference: ICD9CM:238.75
database_cross_reference: ICPC2P:B75008
database_cross_reference: LCH:U003813
database_cross_reference: LCH_NW:sh85106315
database_cross_reference: LCH_NW:sh88001636
database_cross_reference: MDR:10028533
database_cross_reference: MDR:10028534
database_cross_reference: MDR:10028536
database_cross_reference: MDR:10028548
database_cross_reference: MDR:10036587
database_cross_reference: MDR:10054577
database_cross_reference: MEDCIN:35938
database_cross_reference: MEDCIN:98952
database_cross_reference: MEDLINEPLUS:5550
database_cross_reference: MSH:D009190
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3247
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CTCAE:E12552
database_cross_reference: NCI_CTEP-SDC:10028534
database_cross_reference: NCI_NCI-GLOSS:CDR0000045266
database_cross_reference: NCI_NCI-GLOSS:CDR0000045480
database_cross_reference: NCI_NCI-GLOSS:CDR0000045953
database_cross_reference: NCI_NCI-GLOSS:CDR0000046583
database_cross_reference: NCI_NICHD:C3247
database_cross_reference: NDFRT:N0000002079
database_cross_reference: OMIM:614286
database_cross_reference: OMIM:MTHU002415
database_cross_reference: OMIM:MTHU024110
database_cross_reference: PDQ:CDR0000039817
database_cross_reference: RCD:BBv..
database_cross_reference: RCD:ByuHD
database_cross_reference: RCD:Xa0SY
database_cross_reference: RCDSY:BBv..
database_cross_reference: RCDSY:ByuHD
database_cross_reference: SNM:D-4005
database_cross_reference: SNMI:M-99800
database_cross_reference: SNMI:M-99891
database_cross_reference: SNOMEDCT_US:109995007
database_cross_reference: SNOMEDCT_US:109999001
database_cross_reference: SNOMEDCT_US:128623006
database_cross_reference: SNOMEDCT_US:188736006
database_cross_reference: SNOMEDCT_US:189508006
database_cross_reference: SNOMEDCT_US:189515003
database_cross_reference: SNOMEDCT_US:190229005
database_cross_reference: SNOMEDCT_US:25707000
database_cross_reference: SNOMEDCT_US:393565000
database_cross_reference: SNOMEDCT_US:4227006

Neoplasm of the pancreas
type: Class
subclass of: Neoplasm by anatomical site
definition: A tumor (abnormal growth of tissue) of the pancreas.
PMOID: PMO:00014231
Subclass_of: Neoplasm by anatomical site
Synonym: Ca body of pancreas
Synonym: Ca head of pancreas
Synonym: Ca tail of pancreas
Synonym: NEOPL PANCREATIC
Synonym: Neoplasia of the pancreas
Synonym: Neoplasm of Pancreas
Synonym: Neoplasm of pancreas
Synonym: Neoplasm of pancreas (disorder)
Synonym: Neoplasm of the Pancreas
Synonym: Neoplasm, Pancreas
Tree Number: T3.25.1.8
database_cross_reference: AOD:0000023068
database_cross_reference: AOD:0000023069
database_cross_reference: CCPSS:0044979
database_cross_reference: CHV:0000009225
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2014-4876
database_cross_reference: DO:DOID:1793
database_cross_reference: HPO:HP:0002894
database_cross_reference: LCH_NW:sh85097380
database_cross_reference: MDR:10033632
database_cross_reference: MDR:10049099
database_cross_reference: MDR:10050255
database_cross_reference: MDR:10061902
database_cross_reference: MEDCIN:31624
database_cross_reference: MSH:D010190
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3305
database_cross_reference: NDFRT:N0000002288
database_cross_reference: RCD:X309Y
database_cross_reference: RCDAE:X309Y
database_cross_reference: SNOMEDCT_US:126859007

Embryonal neoplasm
type: Class
subclass of: Neoplasm by histology
PMOID: PMO:00014293
Subclass_of: Neoplasm by histology
Synonym: EMBRYONAL NEOPL
Synonym: Embryonal Neoplasm
Synonym: Embryonal Neoplasms
Synonym: Embryonal neoplasia
Synonym: Embryonal tumors
Synonym: NEOPL EMBRYONAL
Synonym: Neoplasm, Embryonal
Synonym: Neoplasms, Embryonal
Synonym: Tumors, Embryonal
Synonym: embryo cancer
Tree Number: T3.25.2.1
database_cross_reference: AOD:0000004545
database_cross_reference: AOD:0000023019
database_cross_reference: CSP:2000-3997
database_cross_reference: DO:DOID:688
database_cross_reference: HPO:HP:0002898
database_cross_reference: LCH:U005815
database_cross_reference: LCH_NW:sh85138564
database_cross_reference: MSH:D009373
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3264
database_cross_reference: NCI_NCI-GLOSS:CDR0000367442
database_cross_reference: OMIM:MTHU006872

Hyperbilirubinemia
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An increased amount of bilirubin in the blood.
PMOID: PMO:00004256
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: BILIRUBINAEMIA
Synonym: BILIRUBINEMIA
Synonym: Bilirubinaemia
Synonym: Bilirubinemia
Synonym: Bilirubinemia, NOS
Synonym: Bilirubinemias
Synonym: Disorder characterized by elevated serum bilirubin
Synonym: HYPERBILIRUBINEMIA
Synonym: High blood bilirubin levels
Synonym: Hyper bilirubinaemia
Tree Number: T3.6.29
database_cross_reference: AOD:0000005794
database_cross_reference: CHV:0000006402
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1653-7010
database_cross_reference: CST:BILIRUBINEM
database_cross_reference: DO:DOID:2741
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0002904
database_cross_reference: LCH:U002301
database_cross_reference: LCH_NW:sh85063672
database_cross_reference: MDR:10004702
database_cross_reference: MDR:10004705
database_cross_reference: MDR:10020551
database_cross_reference: MDR:10020578
database_cross_reference: MDR:10020582
database_cross_reference: MEDCIN:273599
database_cross_reference: MSH:D006932
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000255
database_cross_reference: MTH:U000288
database_cross_reference: MTH:U000343
database_cross_reference: MTH:U000372
database_cross_reference: NDFRT:N0000001575
database_cross_reference: RCD:44E2.
database_cross_reference: RCD:X307e
database_cross_reference: RCDAE:X307e
database_cross_reference: SNM:F-15003
database_cross_reference: SNMI:D6-84005
database_cross_reference: SNMI:D6-84380
database_cross_reference: SNOMEDCT_US:143932000
database_cross_reference: SNOMEDCT_US:14783006
database_cross_reference: SNOMEDCT_US:154770008
database_cross_reference: SNOMEDCT_US:166612004
database_cross_reference: SNOMEDCT_US:20505009
database_cross_reference: SNOMEDCT_US:235904007
database_cross_reference: SNOMEDCT_US:267509000
database_cross_reference: SNOMEDCT_VET:14783006
database_cross_reference: SNOMEDCT_VET:166612004

Conjugated hyperbilirubinemia
type: Class
subclass of: Hyperbilirubinemia
PMOID: PMO:00004257
Subclass_of: Hyperbilirubinemia
Synonym: Conjugated Hyperbilirubinemia
Synonym: Conjugated hyperbilirubinaemia
Synonym: Conjugated hyperbilirubinemia (disorder)
Synonym: Conjugated hyperbilirubinemia, NOS
Synonym: Direct Hyperbilirubinemia
Synonym: Direct hyperbilirubinaemia
Synonym: Direct hyperbilirubinemia
Synonym: Hyperbilirubinemia, conjugated
Synonym: Hyperbilirubinemia, direct
Synonym: conjugated hyperbilirubinemia
Tree Number: T3.6.29.1
database_cross_reference: CHV:0000026291
database_cross_reference: HPO:HP:0002908
database_cross_reference: MDR:10075815
database_cross_reference: MDR:10075821
database_cross_reference: MEDCIN:362610
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C113768
database_cross_reference: NCI_NICHD:C113768
database_cross_reference: OMIM:MTHU009469
database_cross_reference: OMIM:MTHU024631
database_cross_reference: OMIM:MTHU032108
database_cross_reference: RCD:X307k
database_cross_reference: RCDAE:X307k
database_cross_reference: SNMI:D6-84200
database_cross_reference: SNOMEDCT_US:9326001

Abnormality of chromosome segregation
type: Class
subclass of: Abnormal cellular physiology
definition: An abnormality of chromosome segregation.
PMOID: PMO:00003480
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.3
database_cross_reference: HPO:HP:0002916

Abnormality of thyroid physiology
type: Class
subclass of: Abnormality of the thyroid gland
definition: An abnormal functionality of the thyroid gland.
PMOID: PMO:00006326
Subclass_of: Abnormality of the thyroid gland
Synonym: Abnormal thyroid function
Tree Number: T3.12.10.2
database_cross_reference: HPO:HP:0002926

Leydig cell insensitivity to gonadotropin
type: Class
subclass of: Puberty and gonadal disorders
PMOID: PMO:00006415
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.8
database_cross_reference: HPO:HP:0002929

Aldehyde oxidase deficiency
type: Class
subclass of: Abnormality of carboxylic acid metabolism
definition: A reduction in aldehyde oxidase activity.
PMOID: PMO:00003911
Subclass_of: Abnormality of carboxylic acid metabolism
Synonym: Deficiency of aldehyde oxidase
Synonym: Deficiency of aldehyde oxidase (disorder)
Tree Number: T3.6.11.4
database_cross_reference: HPO:HP:0002932
database_cross_reference: SNOMEDCT_US:124161002

Immune dysregulation
type: Class
subclass of: Abnormality of immune system physiology
definition: Altered immune function characterized by lymphoid proliferation, immune activation, and excessive autoreactivity often leading to autoimmune/inflammatory complications.
PMOID: PMO:00008601
Subclass_of: Abnormality of immune system physiology
Synonym: Unregulated immune response
Tree Number: T3.15.2.9
database_cross_reference: HPO:HP:0002958

Autoimmunity
type: Class
subclass of: Abnormality of immune system physiology
definition: The occurrence of an immune reaction against the organism's own cells or tissues.
PMOID: PMO:00008568
Subclass_of: Abnormality of immune system physiology
Synonym: AUTOIMMUNE DIS
Synonym: AUTOIMMUNE DISEASE
Synonym: AUTOIMMUNE DISORDER
Synonym: Autoimmune Disease
Synonym: Autoimmune Diseases
Synonym: Autoimmune Diseases [Disease/Finding]
Synonym: Autoimmune Disorder
Synonym: Autoimmune Disorders
Synonym: Autoimmune condition
Synonym: Autoimmune disease
Tree Number: T3.15.2.7
database_cross_reference: AOD:0000005956
database_cross_reference: AOD:0000023560
database_cross_reference: CCPSS:0022871
database_cross_reference: CHV:0000001603
database_cross_reference: CHV:0000001605
database_cross_reference: CSP:1560-5548
database_cross_reference: CSP:4003-0004
database_cross_reference: DXP:U000296
database_cross_reference: HPO:HP:0002960
database_cross_reference: ICD10CM:M30-M36
database_cross_reference: LCH:U000443
database_cross_reference: LCH_NW:sh85010076
database_cross_reference: LCH_NW:sh87006465
database_cross_reference: LNC:LP128504-0
database_cross_reference: LNC:LP130888-3
database_cross_reference: LNC:MTHU040269
database_cross_reference: LNC:MTHU040494
database_cross_reference: MDR:10003815
database_cross_reference: MDR:10003816
database_cross_reference: MDR:10061664
database_cross_reference: MEDCIN:98338
database_cross_reference: MEDLINEPLUS:154
database_cross_reference: MSH:D001327
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:279.49
database_cross_reference: NCI:C2889
database_cross_reference: NCI_CTCAE:E11258
database_cross_reference: NCI_FDA:1732
database_cross_reference: NCI_NCI-GLOSS:CDR0000045604
database_cross_reference: NCI_NICHD:C2889
database_cross_reference: NDFRT:N0000000514
database_cross_reference: OMIM:109100
database_cross_reference: OMIM:MTHU027840
database_cross_reference: OMIM:MTHU028125
database_cross_reference: OMIM:MTHU055602
database_cross_reference: PSY:04920
database_cross_reference: RCD:C394.
database_cross_reference: RCD:Xa2b1
database_cross_reference: SNM:D-4700
database_cross_reference: SNM:U000015
database_cross_reference: SNMI:DC-50020
database_cross_reference: SNOMEDCT_US:191006002
database_cross_reference: SNOMEDCT_US:85828009

Abnormality of the forearm
type: Class
subclass of: Abnormality of the upper limb
definition: An abnormality of the lower arm.
PMOID: PMO:00002864
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.2
database_cross_reference: HPO:HP:0002973

Abnormality of the calf
type: Class
subclass of: Abnormality of the lower limb
definition: An abnormality of the calf, i.e. of the posterior part of the lower leg.
PMOID: PMO:00002729
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.3
database_cross_reference: HPO:HP:0002981

Prolonged bleeding time
type: Class
subclass of: Abnormal bleeding
definition: Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding.
PMOID: PMO:00000923
Subclass_of: Abnormal bleeding
Synonym: Increased bleeding time
Tree Number: T3.2.1.12
database_cross_reference: HPO:HP:0003010

Abnormality of the musculature
type: Class
subclass of: Phenotypic Abnormality
definition: Abnormality originating in one or more muscles, i.e., of the set of muscles of body.
PMOID: PMO:00009456
Subclass_of: Phenotypic Abnormality
Synonym: Muscular abnormality
Tree Number: T3.17
database_cross_reference: HPO:HP:0003011

Hypoproteinemia
type: Class
subclass of: Abnormality of circulating protein level
definition: A decreased concentration of protein in the blood.
PMOID: PMO:00003966
Subclass_of: Abnormality of circulating protein level
Synonym: HYPOPROTEINAEMIA
Synonym: HYPOPROTEINEMIA
Synonym: Hypoproteinaemia
Synonym: Hypoproteinaemia, NOS
Synonym: Hypoproteinemia (disorder)
Synonym: Hypoproteinemia [Disease/Finding]
Synonym: Hypoproteinemia, NOS
Synonym: Hypoproteinemias
Synonym: hypoproteinaemia
Synonym: hypoproteinemia
Tree Number: T3.6.12.20
database_cross_reference: AOD:0000005745
database_cross_reference: CCPSS:1006879
database_cross_reference: CHV:0000006489
database_cross_reference: CSP:0449-7033
database_cross_reference: CST:HYPOPROTEINEM
database_cross_reference: CST:METHYPOPROT
database_cross_reference: HPO:HP:0003075
database_cross_reference: MDR:10021083
database_cross_reference: MDR:10021084
database_cross_reference: MEDCIN:313654
database_cross_reference: MSH:D007019
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000348
database_cross_reference: NCI:C88511
database_cross_reference: NDFRT:N0000001646
database_cross_reference: OMIM:MTHU001376
database_cross_reference: RCD:C33y0
database_cross_reference: RCDAE:C33y0
database_cross_reference: SNM:F-12214
database_cross_reference: SNMI:D6-10244
database_cross_reference: SNOMEDCT_US:154750002
database_cross_reference: SNOMEDCT_US:267503004
database_cross_reference: SNOMEDCT_US:8900005
database_cross_reference: SNOMEDCT_VET:60439007

Hyperlipidemia
type: Class
subclass of: Abnormality of lipid metabolism
definition: An elevated lipid concentration in the blood.
PMOID: PMO:00004132
Subclass_of: Abnormality of lipid metabolism
Synonym: Disorder characterized by hyperlipidemia
Synonym: HLD - Hyperlipidaemia
Synonym: HLD - Hyperlipidemia
Synonym: HYPERLIPAEMIA
Synonym: HYPERLIPEMIA
Synonym: HYPERLIPIDEMIA
Synonym: Hyperlipaemia
Synonym: Hyperlipemia
Synonym: Hyperlipemias
Synonym: Hyperlipidaemia
Tree Number: T3.6.17.6
database_cross_reference: AOD:0000005732
database_cross_reference: BI:BI00109
database_cross_reference: CCPSS:1006712
database_cross_reference: CHV:0000006419
database_cross_reference: COSTAR:395
database_cross_reference: CSP:1744-2444
database_cross_reference: CST:HYPERLIPEM
database_cross_reference: DO:DOID:1168
database_cross_reference: DXP:U002027
database_cross_reference: HPO:HP:0003077
database_cross_reference: ICD10:E78.5
database_cross_reference: ICD10AM:E78.5
database_cross_reference: ICD10AMAE:E78.5
database_cross_reference: ICD10CM:E78.5
database_cross_reference: ICPC2P:T93008
database_cross_reference: LCH:U002308
database_cross_reference: LCH_NW:sh85063704
database_cross_reference: MDR:10020661
database_cross_reference: MDR:10020662
database_cross_reference: MDR:10020663
database_cross_reference: MDR:10020667
database_cross_reference: MDR:10062060
database_cross_reference: MEDLINEPLUS:26
database_cross_reference: MEDLINEPLUS:4277
database_cross_reference: MSH:D006949
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:272.4
database_cross_reference: NCI:C34707
database_cross_reference: NDFRT:N0000001592
database_cross_reference: OMIM:MTHU002043
database_cross_reference: RCD:C324.
database_cross_reference: RCD:X40Wy
database_cross_reference: RCDAE:C324.
database_cross_reference: RCDAE:X40Wy
database_cross_reference: SNMI:D6-60010
database_cross_reference: SNOMEDCT_US:154739000
database_cross_reference: SNOMEDCT_US:154743001
database_cross_reference: SNOMEDCT_US:190782002
database_cross_reference: SNOMEDCT_US:267499005
database_cross_reference: SNOMEDCT_US:55822004
database_cross_reference: SNOMEDCT_VET:55822004

Abnormality of cholesterol metabolism
type: Class
subclass of: Abnormality of lipid metabolism
PMOID: PMO:00004071
Subclass_of: Abnormality of lipid metabolism
Tree Number: T3.6.17.2
database_cross_reference: HPO:HP:0003107

Abnormality of ion homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: Abnormality of the homeostasis (concentration) of a monoatomic ion.
PMOID: PMO:00004005
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.15
database_cross_reference: HPO:HP:0003111

Abnormal echocardiogram
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: An abnormality detectable by sonography of the heart (echocardiography).
PMOID: PMO:00004729
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: Abnormal echocardiography
Tree Number: T3.9.3.3
database_cross_reference: HPO:HP:0003116

Abnormality of circulating hormone level
type: Class
subclass of: Abnormality of the endocrine system
definition: An abnormal concentration of a hormone in the blood.
PMOID: PMO:00006126
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.3
database_cross_reference: HPO:HP:0003117

Abnormality of lipid metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality in the of lipid metabolism.
PMOID: PMO:00004066
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.17

Limb joint contracture
type: Class
subclass of: Flexion contracture
definition: A contrqacture (chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin) that prevent normal movement of one or more joints of the limbs.
PMOID: PMO:00001338
Subclass_of: Flexion contracture
Synonym: Limb contractures
Tree Number: T3.3.6.6
database_cross_reference: HPO:HP:0003121

Increased serum serotonin
type: Class
subclass of: Abnormality of circulating hormone level
definition: A increased concentration of serotonin in the blood.
PMOID: PMO:00006199
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.25
database_cross_reference: HPO:HP:0003144

Hyperuricosuria
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: An abnormally high level of uric acid in the urine.
PMOID: PMO:00004161
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: High urine uric acid level
Tree Number: T3.6.18.8
database_cross_reference: HPO:HP:0003149

Increased serum 1,25-dihydroxyvitamin D3
type: Class
subclass of: Abnormality of circulating hormone level
PMOID: PMO:00006198
Subclass_of: Abnormality of circulating hormone level
Synonym: Increased serum calcitriol
Tree Number: T3.12.3.24
database_cross_reference: HPO:HP:0003152

Fasting hypoglycemia
type: Class
subclass of: Abnormality of circulating hormone level
PMOID: PMO:00006194
Subclass_of: Abnormality of circulating hormone level
Synonym: Fasting Hypoglycemia
Synonym: Fasting hypoglycaemia
Synonym: Fasting hypoglycemia (disorder)
Synonym: Hypoglycemia, Fasting
Synonym: Hypoglycemia, Postabsorptive
Synonym: Low blood sugar when fasting
Synonym: Postabsorptive Hypoglycemia
Synonym: fasting hypoglycemia
Tree Number: T3.12.3.21
database_cross_reference: CHV:0000026660
database_cross_reference: HPO:HP:0003162
database_cross_reference: MDR:10078708
database_cross_reference: MDR:10078719
database_cross_reference: MSH:D007003
database_cross_reference: OMIM:MTHU011882
database_cross_reference: RCD:X40K2
database_cross_reference: RCDAE:X40K2
database_cross_reference: SNMI:DB-63220
database_cross_reference: SNOMEDCT_US:6974005

Elevated urinary delta-aminolevulinic acid
type: Class
subclass of: Abnormality of the heme biosynthetic pathway
definition: An increased concentration of 5-aminolevulinic acid (CHEBI:17549) in the urine.
PMOID: PMO:00004197
Subclass_of: Abnormality of the heme biosynthetic pathway
Tree Number: T3.6.22.1
database_cross_reference: HPO:HP:0003163

Elevated circulating parathyroid hormone level
type: Class
subclass of: Abnormality of calcium-phosphate metabolism
definition: An abnormal increased concentration of parathyroid hormone.
PMOID: PMO:00003640
Subclass_of: Abnormality of calcium-phosphate metabolism
Synonym: Elevated circulating PTH level
Synonym: Elevated serum parathyroid hormone
Synonym: Elevated serum parathyroid hormone level
Synonym: Elevated serum pth
Synonym: Increased serum parathyroid hormone
Tree Number: T3.6.9.3
database_cross_reference: HPO:HP:0003165

Myopathy
type: Class
subclass of: Abnormal muscle morphology
definition: A disorder of muscle unrelated to impairment of innervation or neuromuscular junction.
PMOID: PMO:00009573
Subclass_of: Abnormal muscle morphology
Synonym: A-51 MYOPATHIES
Synonym: DISORDER MUSCLE
Synonym: Disorder muscle
Synonym: Disorder of muscle
Synonym: Disorder of muscle (disorder)
Synonym: Disorder of muscle -RETIRED-
Synonym: Disorder of muscle, NOS
Synonym: Disorder of muscle, unspec
Synonym: Disorder of muscle, unspecified
Synonym: Disorder of skeletal AND/OR smooth muscle
Tree Number: T3.17.1.11
database_cross_reference: AOD:0000005063
database_cross_reference: AOD:0000005066
database_cross_reference: BI:BI00507
database_cross_reference: CCPSS:0045912
database_cross_reference: CCPSS:1018022
database_cross_reference: CHV:0000008361
database_cross_reference: COSTAR:U000457
database_cross_reference: CSP:1982-9451
database_cross_reference: CST:MS/MUS
database_cross_reference: CST:MYOPATHY
database_cross_reference: DO:DOID:0080000
database_cross_reference: DO:DOID:423
database_cross_reference: DO:DOID:66
database_cross_reference: DXP:U002703
database_cross_reference: HPO:HP:0003198
database_cross_reference: ICD10:G72.9
database_cross_reference: ICD10:M60-M63.9
database_cross_reference: ICD10:M62.9
database_cross_reference: ICD10AM:G72.9
database_cross_reference: ICD10AM:M60-M63.9
database_cross_reference: ICD10AM:M62.9
database_cross_reference: ICD10CM:G72.9
database_cross_reference: ICD10CM:M60-M63
database_cross_reference: ICD10CM:M62.9
database_cross_reference: ICD9CM:359.9
database_cross_reference: ICPC2P:L99023
database_cross_reference: LCH_NW:sh85088688
database_cross_reference: MDR:10013237
database_cross_reference: MDR:10028300
database_cross_reference: MDR:10028301
database_cross_reference: MDR:10028302
database_cross_reference: MDR:10028640
database_cross_reference: MDR:10028641
database_cross_reference: MDR:10028649
database_cross_reference: MEDCIN:319450
database_cross_reference: MEDCIN:91077
database_cross_reference: MEDLINEPLUS:510
database_cross_reference: MSH:D009135
database_cross_reference: MTH:503
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101216
database_cross_reference: NCI_NICHD:C101216
database_cross_reference: NDFRT:N0000002064
database_cross_reference: OMIM:590030
database_cross_reference: OMIM:590075
database_cross_reference: OMIM:MTHU003653
database_cross_reference: OMIM:MTHU049021
database_cross_reference: PSY:32600
database_cross_reference: RCD:Nyu8B
database_cross_reference: RCD:X708D
database_cross_reference: RCD:X708s
database_cross_reference: RCDSY:Nyu8B
database_cross_reference: SNM:D-8004
database_cross_reference: SNM:D-8060
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D1-50010
database_cross_reference: SNMI:DA-51000
database_cross_reference: SNOMEDCT_US:129565002
database_cross_reference: SNOMEDCT_US:155094005
database_cross_reference: SNOMEDCT_US:155099000
database_cross_reference: SNOMEDCT_US:203833006
database_cross_reference: SNOMEDCT_US:203845002
database_cross_reference: SNOMEDCT_US:267711006
database_cross_reference: SNOMEDCT_US:267714003

Decreased muscle mass
type: Class
subclass of: Abnormal muscle morphology
PMOID: PMO:00009563
Subclass_of: Abnormal muscle morphology
Synonym: Underdeveloped muscles
Tree Number: T3.17.1.4
database_cross_reference: HPO:HP:0003199

Rhabdomyolysis
type: Class
subclass of: Abnormal muscle morphology
definition: Breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream.
PMOID: PMO:00009581
Subclass_of: Abnormal muscle morphology
Synonym: Necrosis of skeletal muscle
Synonym: Necrosis of skeletal muscle (finding)
Synonym: RHABDOMYOLYSIS
Synonym: Rhabdomyolyses
Synonym: Rhabdomyolysis (disorder)
Synonym: Rhabdomyolysis (morphologic abnormality)
Synonym: Rhabdomyolysis [Disease/Finding]
Synonym: Skeletal muscle necrosis
Synonym: rhabdomyolysis
Synonym: rhabdomyolysis (diagnosis)
Tree Number: T3.17.1.12
database_cross_reference: AOD:0000005067
database_cross_reference: CCPSS:0041860
database_cross_reference: CHV:0000010835
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:RHABDO
database_cross_reference: HPO:HP:0003201
database_cross_reference: ICD10CM:M62.82
database_cross_reference: ICD9CM:728.88
database_cross_reference: LCH_NW:sh87007562
database_cross_reference: MDR:10039020
database_cross_reference: MEDCIN:272819
database_cross_reference: MEDLINEPLUS:510
database_cross_reference: MSH:D012206
database_cross_reference: NCI:C118318
database_cross_reference: NCI_NICHD:C118318
database_cross_reference: NDFRT:N0000002626
database_cross_reference: OMIM:MTHU036873
database_cross_reference: RCD:X70AI
database_cross_reference: SNM:M-51500
database_cross_reference: SNMI:M-51570
database_cross_reference: SNOMEDCT_US:156729009
database_cross_reference: SNOMEDCT_US:240131006
database_cross_reference: SNOMEDCT_US:268106003
database_cross_reference: SNOMEDCT_US:89010004
database_cross_reference: SNOMEDCT_VET:240131006
database_cross_reference: SNOMEDCT_VET:311511000009102

Skeletal muscle atrophy
type: Class
subclass of: Abnormality of skeletal muscles
definition: The presence of skeletal muscular atrophy (which is also known as amyotrophy).
PMOID: PMO:00009673
Subclass_of: Abnormality of skeletal muscles
Synonym: ATROPHY SKELETAL MUSCLE
Synonym: Amyotrophy
Synonym: Amyotrophy involving the extremities
Synonym: Atrophy skeletal muscle
Synonym: Muscle atrophy
Synonym: Muscle hypotrophy
Synonym: Muscle wasting
Synonym: Muscular atrophy
Synonym: skeletal muscle atrophy
Tree Number: T3.17.5.1
database_cross_reference: CST:ATROPHY MUSCLE
database_cross_reference: GO:GO:0014732
database_cross_reference: HPO:HP:0003202
database_cross_reference: MDR:10003718
database_cross_reference: MTH:NOCODE

Intracellular accumulation of autofluorescent lipopigment storage material
type: Class
subclass of: Abnormal cellular physiology
definition: The intracellular accumulation of autofluorescent storage material.
PMOID: PMO:00003531
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.12
database_cross_reference: HPO:HP:0003204

Decreased activity of NADPH oxidase
type: Class
subclass of: Abnormality of superoxide metabolism
PMOID: PMO:00004184
Subclass_of: Abnormality of superoxide metabolism
Tree Number: T3.6.20.1
database_cross_reference: HPO:HP:0003206

Decreased pyruvate carboxylase activity
type: Class
subclass of: Abnormality of Krebs cycle metabolism
definition: A decreased rate of pyruvate carboxylase activity.
PMOID: PMO:00004065
Subclass_of: Abnormality of Krebs cycle metabolism
Tree Number: T3.6.16.3
database_cross_reference: HPO:HP:0003209

Decreased methylmalonyl-CoA mutase activity
type: Class
subclass of: Abnormality of Krebs cycle metabolism
definition: An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of methylmalonyl-CoA mutase activity.
PMOID: PMO:00004064
Subclass_of: Abnormality of Krebs cycle metabolism
Synonym: Decreased methylmalonyl CoA mutase activity
Tree Number: T3.6.16.2
database_cross_reference: HPO:HP:0003210

Generalized amyloid deposition
type: Class
subclass of: Amyloidosis
definition: A diffuse form of amyloidosis.
PMOID: PMO:00004246
Subclass_of: Amyloidosis
Tree Number: T3.6.24.6
database_cross_reference: HPO:HP:0003216

Abnormality of chromosome stability
type: Class
subclass of: Abnormal cellular physiology
definition: A type of chromosomal aberration reduced resistance of chromosomes to change or deterioration.
PMOID: PMO:00003484
Subclass_of: Abnormal cellular physiology
Synonym: Breakage, Chromosomal
Synonym: Breakage, Chromosome
Synonym: Breakages, Chromosomal
Synonym: Breakages, Chromosome
Synonym: Chromosomal Breakage
Synonym: Chromosomal Breakages
Synonym: Chromosome Breakage
Synonym: Chromosome Breakage [Disease/Finding]
Synonym: Chromosome Breakages
Synonym: Chromosome breakage
Tree Number: T3.6.2.4
database_cross_reference: GO:GO:0031052
database_cross_reference: HPO:HP:0003220
database_cross_reference: HPO:HP:0040012
database_cross_reference: LNC:LP32790-5
database_cross_reference: LNC:MTHU016278
database_cross_reference: MSH:D019457
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85870
database_cross_reference: NDFRT:N0000003925
database_cross_reference: OMIM:MTHU049773

Increased cellular sensitivity to UV light
type: Class
subclass of: Abnormal cellular physiology
PMOID: PMO:00003529
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.10
database_cross_reference: HPO:HP:0003224

Hyperpepsinogenemia I
type: Class
subclass of: Abnormality of circulating protein level
PMOID: PMO:00003964
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.18
database_cross_reference: HPO:HP:0003238

Increased phosphoribosylpyrophosphate synthetase
type: Class
subclass of: Abnormality of nucleobase metabolism
PMOID: PMO:00004182
Subclass_of: Abnormality of nucleobase metabolism
Synonym: Increased PRPP synthetase
Tree Number: T3.6.19.3
database_cross_reference: HPO:HP:0003240

Abnormality of DNA repair
type: Class
subclass of: Abnormal cellular physiology
definition: An abnormality of the process of DNA repair, that is, of the process of restoring DNA after damage.
PMOID: PMO:00003490
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.5
database_cross_reference: HPO:HP:0003254

Abnormality of the coagulation cascade
type: Class
subclass of: Abnormality of coagulation
definition: An abnormality of the coagulation cascade, which is comprised of the contact activation pathway (also known as the intrinsic pathway) and the tissue factor pathway (also known as the extrinsic pathway) as well as cofactors and regulators.
PMOID: PMO:00001154
Subclass_of: Abnormality of coagulation
Synonym: (Coagulation defects) or (bleeding disorders)
Synonym: (Coagulation defects) or (bleeding disorders) (disorder)
Synonym: Abnormal;coagulation
Synonym: BLOOD COAG DIS
Synonym: BLOOD COAGULATION DEFECT
Synonym: BLOOD COAGULATION DISORDER
Synonym: Blood Coagulation Disorder
Synonym: Blood Coagulation Disorders
Synonym: Blood Coagulation Disorders [Disease/Finding]
Synonym: Blood Coagulation Disorders, Diseases and Syndromes
Tree Number: T3.2.8.2
database_cross_reference: AOD:0000005928
database_cross_reference: AOD:0000005929
database_cross_reference: CCPSS:0027739
database_cross_reference: CHV:0000001990
database_cross_reference: COSTAR:188
database_cross_reference: COSTAR:U000185
database_cross_reference: CSP:0438-1873
database_cross_reference: CST:COAGUL DIS
database_cross_reference: CST:HAL/COAG
database_cross_reference: DO:DOID:1247
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000386
database_cross_reference: HPO:HP:0001928
database_cross_reference: HPO:HP:0003256
database_cross_reference: ICD10:D68.9
database_cross_reference: ICD10AM:D68.9
database_cross_reference: ICD10CM:D68.9
database_cross_reference: ICD9CM:286
database_cross_reference: ICPC2P:B83001
database_cross_reference: LCH:U006363
database_cross_reference: LCH_NW:sh85014937
database_cross_reference: MDR:10009727
database_cross_reference: MDR:10009729
database_cross_reference: MDR:10009731
database_cross_reference: MDR:10009734
database_cross_reference: MDR:10009802
database_cross_reference: MDR:10012116
database_cross_reference: MDR:10013206
database_cross_reference: MDR:10048498
database_cross_reference: MDR:10053567
database_cross_reference: MDR:10064732
database_cross_reference: MEDCIN:35838
database_cross_reference: MEDLINEPLUS:166
database_cross_reference: MEDLINEPLUS:3115
database_cross_reference: MSH:D001778
database_cross_reference: MTH:188
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:286.9
database_cross_reference: NCI:C2902
database_cross_reference: NCI_FDA:1779
database_cross_reference: NCI_NICHD:C2902
database_cross_reference: NDFRT:N0000000575
database_cross_reference: OMIM:MTHU008649
database_cross_reference: OMIM:MTHU033936
database_cross_reference: RCD:D30..
database_cross_reference: RCD:D30z.
database_cross_reference: SNM:D-4400
database_cross_reference: SNM:F-54302
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DC-60000
database_cross_reference: SNOMEDCT_US:127073005
database_cross_reference: SNOMEDCT_US:154815003
database_cross_reference: SNOMEDCT_US:191303002
database_cross_reference: SNOMEDCT_US:267562007
database_cross_reference: SNOMEDCT_US:362970003
database_cross_reference: SNOMEDCT_US:64779008

Glyoxalase deficiency
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
PMOID: PMO:00003737
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.13
database_cross_reference: HPO:HP:0003258

Neonatal hyperbilirubinemia
type: Class
subclass of: Hyperbilirubinemia
definition: A type of hyperbilirubinemia with neonatal onset.
PMOID: PMO:00004259
Subclass_of: Hyperbilirubinemia
Synonym: ICTERUS NEONATORUM
Synonym: Icterus neonatorum
Synonym: Icterus neonatorum unspecified
Synonym: Icterus neonatorum, unspecified
Synonym: Icterus neonatorum, unspecified (disorder)
Synonym: JAUNDICE NEONATAL
Synonym: Jaundice in baby
Synonym: Jaundice neonatal
Synonym: Jaundice of newborn
Synonym: Jaundice, Neonatal
Tree Number: T3.6.29.3
database_cross_reference: AOD:0000004961
database_cross_reference: CHV:0000006993
database_cross_reference: CHV:0000044108
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:JAUNDICE NEONAT
database_cross_reference: DO:DOID:2383
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0006579
database_cross_reference: ICD10:P59.9
database_cross_reference: ICD10AM:P59.9
database_cross_reference: ICD10CM:P59.9
database_cross_reference: ICPC2P:A94001
database_cross_reference: ICPC2P:A94010
database_cross_reference: LCH:U002535
database_cross_reference: LCH_NW:sh85069784
database_cross_reference: MDR:10021210
database_cross_reference: MDR:10023137
database_cross_reference: MDR:10023138
database_cross_reference: MDR:10023141
database_cross_reference: MDR:10028953
database_cross_reference: MEDCIN:95175
database_cross_reference: MSH:D007567
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:774.6
database_cross_reference: NCI:C99246
database_cross_reference: NCI_NICHD:C99246
database_cross_reference: NDFRT:N0000001716
database_cross_reference: OMIM:MTHU003015
database_cross_reference: OMIM:MTHU012768
database_cross_reference: RCD:Q4360
database_cross_reference: RCD:X70Ea
database_cross_reference: RCD:Xa7MW
database_cross_reference: SNM:M-57600
database_cross_reference: SNMI:D8-74500
database_cross_reference: SNMI:D8-74510
database_cross_reference: SNOMEDCT_US:111470007
database_cross_reference: SNOMEDCT_US:206474007
database_cross_reference: SNOMEDCT_US:276549000
database_cross_reference: SNOMEDCT_US:299968002
database_cross_reference: SNOMEDCT_US:30235009
database_cross_reference: SNOMEDCT_US:31482007
database_cross_reference: SNOMEDCT_US:387712008

Visceromegaly
type: Class
subclass of: Abnormality of abdomen morphology
definition: Abnormal increased size of the viscera of the abdomen.
PMOID: PMO:00005310
Subclass_of: Abnormality of abdomen morphology
Synonym: Visceromegaly (morphologic abnormality)
Tree Number: T3.10.1.7
database_cross_reference: HPO:HP:0003271
database_cross_reference: OMIM:MTHU032587
database_cross_reference: SNM:M-71000
database_cross_reference: SNMI:M-710B0
database_cross_reference: SNOMEDCT_US:28543008

Myalgia
type: Class
subclass of: Pain
definition: Pain in muscle.
PMOID: PMO:00014104
Subclass_of: Pain
Synonym: Aching muscles
Synonym: GENERALIZED MYALGIA
Synonym: Generalised muscle aches
Synonym: Generalized muscle aches
Synonym: MUSCLE ACHE
Synonym: MUSCLE DISCOMFORT
Synonym: MUSCLE PAIN
Synonym: MUSCLE PAIN GENERALIZED
Synonym: MUSCLE SORENESS
Synonym: MUSCULAR PAIN
Tree Number: T3.23.10.23
database_cross_reference: AOD:0000005145
database_cross_reference: BI:BI00501
database_cross_reference: BI:BI00506
database_cross_reference: CCPSS:0011037
database_cross_reference: CCPSS:0016545
database_cross_reference: CCPSS:1016075
database_cross_reference: CHV:0000022710
database_cross_reference: COSTAR:504
database_cross_reference: COSTAR:U000039
database_cross_reference: COSTAR:U000427
database_cross_reference: CST:MYALGIA
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001657
database_cross_reference: HPO:HP:0003326
database_cross_reference: ICD10:M79.1
database_cross_reference: ICD10AM:M79.1
database_cross_reference: ICD10CM:M79.1
database_cross_reference: ICPC2EENG:L18
database_cross_reference: ICPC2P:L18003
database_cross_reference: ICPC2P:L18006
database_cross_reference: LNC:MTHU013523
database_cross_reference: MDR:10018089
database_cross_reference: MDR:10028287
database_cross_reference: MDR:10028299
database_cross_reference: MDR:10028322
database_cross_reference: MDR:10028323
database_cross_reference: MDR:10028332
database_cross_reference: MDR:10028361
database_cross_reference: MDR:10028362
database_cross_reference: MDR:10028411
database_cross_reference: MDR:10033466
database_cross_reference: MDR:10062441
database_cross_reference: MEDCIN:1001
database_cross_reference: MEDCIN:1002
database_cross_reference: MSH:D063806
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C27009
database_cross_reference: NCI:C35785
database_cross_reference: NCI_CTCAE:E12485
database_cross_reference: NCI_FDA:2238
database_cross_reference: NCI_NCI-GLOSS:CDR0000044501
database_cross_reference: NCI_NICHD:C27009
database_cross_reference: NDFRT:N0000189366
database_cross_reference: OMIM:MTHU002772
database_cross_reference: OMIM:MTHU005259
database_cross_reference: OMIM:MTHU018310
database_cross_reference: OMIM:MTHU045047
database_cross_reference: RCD:X75rs
database_cross_reference: RCD:XE1Fm
database_cross_reference: SNM:F-82600
database_cross_reference: SNMI:F-11550
database_cross_reference: SNMI:F-11556
database_cross_reference: SNOMEDCT_US:203109002
database_cross_reference: SNOMEDCT_US:268010003
database_cross_reference: SNOMEDCT_US:268108002
database_cross_reference: SNOMEDCT_US:68962001

Abnormal bone structure
type: Class
subclass of: Abnormality of skeletal morphology
definition: Any anomaly in the composite material or the layered arrangement of the bony skeleton.
PMOID: PMO:00013616
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.3
database_cross_reference: HPO:HP:0003330

Glutathione synthetase deficiency
type: Class
subclass of: Abnormality of metabolism/homeostasis
PMOID: PMO:00004255
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: 5 oxoprolinuria
Synonym: 5-OXOPROLINURIA
Synonym: 5-Oxoprolinuria
Synonym: 5-oxoprolinemia
Synonym: 5-oxoprolinuria
Synonym: Deficiency of Glutathione Synthase
Synonym: Deficiency of Glutathione Synthetase
Synonym: Deficiency of glutathione synthase
Synonym: Deficiency of glutathione synthase (disorder)
Synonym: Deficiency of glutathione synthetase
Tree Number: T3.6.28
database_cross_reference: CHV:0000026319
database_cross_reference: HPO:HP:0003343
database_cross_reference: MEDCIN:354196
database_cross_reference: MSH:C536835
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C128193
database_cross_reference: OMIM:266130
database_cross_reference: OMIM:601002
database_cross_reference: RCD:X20Hm
database_cross_reference: RCD:X40SC
database_cross_reference: RCDAE:X40SC
database_cross_reference: SNMI:D6-A3510
database_cross_reference: SNOMEDCT_US:124706000
database_cross_reference: SNOMEDCT_US:234589002
database_cross_reference: SNOMEDCT_US:39112005

Thymic hormone decreased
type: Class
subclass of: Abnormality of the thymus
definition: A reduction in the level of thymic horomone.
PMOID: PMO:00006287
Subclass_of: Abnormality of the thymus
Synonym: Decreased thymic hormone
Tree Number: T3.12.9.4
database_cross_reference: HPO:HP:0003357

Easy fatigability
type: Class
subclass of: Abnormality of nervous system physiology
definition: Increased susceptibility to fatigue.
PMOID: PMO:00011197
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.16
database_cross_reference: HPO:HP:0003388

Muscle cramps
type: Class
subclass of: Abnormality of muscle physiology
definition: Sudden and involuntary contractions of one or more muscles.
PMOID: PMO:00009617
Subclass_of: Abnormality of muscle physiology
Synonym: CRAMP
Synonym: CRAMP MUSCLE
Synonym: Cramp
Synonym: Cramp (disorder)
Synonym: Cramp (finding)
Synonym: Cramp in muscle
Synonym: Cramp in muscle, NOS
Synonym: Cramp muscle
Synonym: Cramp(s)
Synonym: Cramp(s);muscle(s)
Tree Number: T3.17.3.5
database_cross_reference: CCPSS:0003813
database_cross_reference: CCPSS:0059192
database_cross_reference: CHV:0000008346
database_cross_reference: COSTAR:500
database_cross_reference: COSTAR:501
database_cross_reference: CSP:1982-9552
database_cross_reference: CST:HYPERTONIA
database_cross_reference: CST:PAIN
database_cross_reference: DXP:U002675
database_cross_reference: HPO:HP:0003394
database_cross_reference: ICPC2P:L18015
database_cross_reference: ICPC2P:L19011
database_cross_reference: MDR:10011285
database_cross_reference: MDR:10011291
database_cross_reference: MDR:10011293
database_cross_reference: MDR:10028294
database_cross_reference: MDR:10028295
database_cross_reference: MEDCIN:1050
database_cross_reference: MEDLINEPLUS:1707
database_cross_reference: MSH:D009120
database_cross_reference: MTH:501
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34827
database_cross_reference: NCI_FDA:2193
database_cross_reference: NCI_NCI-GLOSS:CDR0000476584
database_cross_reference: NCI_NICHD:C34827
database_cross_reference: NDFRT:N0000002057
database_cross_reference: OMIM:MTHU002773
database_cross_reference: OMIM:MTHU004012
database_cross_reference: OMIM:MTHU022606
database_cross_reference: OMIM:MTHU035348
database_cross_reference: PSY:12320
database_cross_reference: PSY:32550
database_cross_reference: RCD:N23y4
database_cross_reference: RCD:N2472
database_cross_reference: RCD:X00CB
database_cross_reference: SNM:F-81390
database_cross_reference: SNMI:F-11700
database_cross_reference: SNOMEDCT_US:203136000
database_cross_reference: SNOMEDCT_US:55300003

Back pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.
PMOID: PMO:00014083
Subclass_of: Pain
Synonym: Ache, Back
Synonym: Aches, Back
Synonym: BACK ACHE
Synonym: BACK PAIN
Synonym: BACKACHE
Synonym: BACKPAIN
Synonym: Back Ache
Synonym: Back Aches
Synonym: Back Pain
Synonym: Back Pain [Disease/Finding]
Tree Number: T3.23.10.6
database_cross_reference: AOD:0000005113
database_cross_reference: BI:BI00483
database_cross_reference: CCPSS:1015824
database_cross_reference: CHV:0000001662
database_cross_reference: CHV:0000017620
database_cross_reference: CHV:0000050482
database_cross_reference: CHV:0000057318
database_cross_reference: COSTAR:093
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000248
database_cross_reference: CSP:2056-6005
database_cross_reference: CST:PAIN BACK
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000327
database_cross_reference: HPO:HP:0003418
database_cross_reference: ICD10:M54
database_cross_reference: ICD10:M54.9
database_cross_reference: ICD10AM:M54
database_cross_reference: ICD10AM:M54.9
database_cross_reference: ICD10CM:M54
database_cross_reference: ICD10CM:M54.9
database_cross_reference: ICD9CM:724.5
database_cross_reference: ICPC2P:L02002
database_cross_reference: ICPC2P:L02003
database_cross_reference: LCH:U000475
database_cross_reference: LCH_NW:sh85010795
database_cross_reference: LNC:MTHU020857
database_cross_reference: MDR:10003978
database_cross_reference: MDR:10003988
database_cross_reference: MDR:10003993
database_cross_reference: MDR:10003994
database_cross_reference: MDR:10013601
database_cross_reference: MDR:10033380
database_cross_reference: MDR:10033391
database_cross_reference: MDR:10033478
database_cross_reference: MDR:10064734
database_cross_reference: MEDCIN:34448
database_cross_reference: MEDCIN:362255
database_cross_reference: MEDCIN:917
database_cross_reference: MEDLINEPLUS:157
database_cross_reference: MSH:D001416
database_cross_reference: MTH:093
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C41830
database_cross_reference: NCI_CTCAE:E12388
database_cross_reference: NCI_NICHD:C41830
database_cross_reference: NDFRT:N0000000522
database_cross_reference: OMIM:MTHU009307
database_cross_reference: PSY:05275
database_cross_reference: RCD:16C..
database_cross_reference: RCD:16C2.
database_cross_reference: RCD:16CZ.
database_cross_reference: RCD:XE1FE
database_cross_reference: RCD:XM1GI
database_cross_reference: SNM:F-82600
database_cross_reference: SNMI:D1-23760
database_cross_reference: SNMI:F-16300
database_cross_reference: SNOMEDCT_US:139146005
database_cross_reference: SNOMEDCT_US:139148006
database_cross_reference: SNOMEDCT_US:139154007
database_cross_reference: SNOMEDCT_US:156651006
database_cross_reference: SNOMEDCT_US:161889002
database_cross_reference: SNOMEDCT_US:161891005
database_cross_reference: SNOMEDCT_US:161897009

EMG abnormality
type: Class
subclass of: Abnormality of muscle physiology
definition: Abnormal results of investigations using electromyography (EMG).
PMOID: PMO:00009606
Subclass_of: Abnormality of muscle physiology
Synonym: Abnormal EMG
Synonym: Abnormal electromyography finding
Synonym: EMG abnormalities
Synonym: Electromyogram abnormal
Tree Number: T3.17.3.2
database_cross_reference: HPO:HP:0003457

Hypocalcemic tetany
type: Class
subclass of: Abnormality of nervous system physiology
definition: Hyperexcitability of the neuromuscular system related to abnormally low level of calcium in the blood, resulting in carpopedal or generalized spasms.
PMOID: PMO:00011223
Subclass_of: Abnormality of nervous system physiology
Synonym: HYPOCALCEMIC TETANY
Synonym: Hypocalcaemic tetany
Synonym: Hypocalcemic tetany (disorder)
Synonym: TETANY HYPOCALCEMIC
Synonym: Tetany hypocalcaemic
Synonym: Tetany hypocalcemic
Tree Number: T3.18.3.19
database_cross_reference: CST:TETANY HYPOCALCEM
database_cross_reference: HPO:HP:0003472
database_cross_reference: MDR:10020951
database_cross_reference: MDR:10043381
database_cross_reference: MDR:10060381
database_cross_reference: MDR:10060425
database_cross_reference: OMIM:MTHU019662
database_cross_reference: RCD:C3546
database_cross_reference: RCDAE:C3546
database_cross_reference: SNOMEDCT_US:190869004

High urinary gonadotropin level
type: Class
subclass of: Abnormality of urine hormone level
definition: An elevated concentration of a gonadotropin hormone (stimulating hormone or luteinizing hormone) in the urine, consistent with the diagnosis of primary hypogonadism.
PMOID: PMO:00006358
Subclass_of: Abnormality of urine hormone level
Tree Number: T3.12.11.1
database_cross_reference: HPO:HP:0003492

Elevated calcitonin
type: Class
subclass of: Abnormality of calcium-phosphate metabolism
PMOID: PMO:00003639
Subclass_of: Abnormality of calcium-phosphate metabolism
Tree Number: T3.6.9.2
database_cross_reference: HPO:HP:0003528

Delayed oxidation of acetaldehyde
type: Class
subclass of: Abnormality of metabolism/homeostasis
PMOID: PMO:00004251
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.26
database_cross_reference: HPO:HP:0003533

Decreased fumarate hydratase activity
type: Class
subclass of: Abnormality of Krebs cycle metabolism
definition: An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of fumarate hydratase activity.
PMOID: PMO:00004063
Subclass_of: Abnormality of Krebs cycle metabolism
Tree Number: T3.6.16.1
database_cross_reference: HPO:HP:0003536

Subsarcolemmal accumulations of abnormally shaped mitochondria
type: Class
subclass of: Muscle abnormality related to mitochondrial dysfunction
definition: An abnormally increased number of mitochondria in the cytoplasma adjacent to the sarcolemma (muscle cell membrane), whereby the mitochondria also possess an abnormal morphology.
PMOID: PMO:00009757
Subclass_of: Muscle abnormality related to mitochondrial dysfunction
Tree Number: T3.17.15.4
database_cross_reference: HPO:HP:0003548

Abnormality of connective tissue
type: Class
subclass of: Phenotypic Abnormality
definition: Any abnormality of the soft tissues, including both connective tissue (tendons, ligaments, fascia, fibrous tissues, and fat).
PMOID: PMO:00001259
Subclass_of: Phenotypic Abnormality
Tree Number: T3.3
database_cross_reference: HPO:HP:0003549

Muscle stiffness
type: Class
subclass of: Abnormality of muscle physiology
definition: A condition in which muscles cannot be moved quickly without accompanying pain or spasm.
PMOID: PMO:00009623
Subclass_of: Abnormality of muscle physiology
Synonym: MUSCLE STIFFNESS
Synonym: Muscle Stiffness
Synonym: Muscle stiffness (finding)
Synonym: Muscular stiffness
Synonym: STIFFNESS MUSCLE
Synonym: Stiff
Synonym: Stiff Muscles
Synonym: Stiffness muscle
Synonym: Stiffness;muscle(s)
Synonym: muscle stiffness
Tree Number: T3.17.3.7
database_cross_reference: CCPSS:1016474
database_cross_reference: CHV:0000021321
database_cross_reference: CST:HYPERTONIA
database_cross_reference: HPO:HP:0003552
database_cross_reference: ICPC2P:L19008
database_cross_reference: MDR:10028339
database_cross_reference: MDR:10042048
database_cross_reference: MEDCIN:283534
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118433
database_cross_reference: NCI_NICHD:C118433
database_cross_reference: OMIM:MTHU010824
database_cross_reference: RCD:X76mk
database_cross_reference: SNM:F-89160
database_cross_reference: SNMI:F-11320
database_cross_reference: SNOMEDCT_US:16046003
database_cross_reference: SNOMEDCT_US:249919003

Muscle hyperirritability
type: Class
subclass of: Abnormality of muscle physiology
PMOID: PMO:00009622
Subclass_of: Abnormality of muscle physiology
Tree Number: T3.17.3.6
database_cross_reference: HPO:HP:0003559

Muscular dystrophy
type: Class
subclass of: Abnormal muscle morphology
definition: The term dystrophy means abnormal growth. However, muscular dystrophy is used to describe primary myopathies with a genetic basis and a progressive course characterized by progressive skeletal muscle weakness and wasting, defects in muscle proteins, and histological features of muscle fiber degeneration (necrosis) and regeneration. If possible, it is preferred to use other HPO terms to describe the precise phenotypic abnormalities.
PMOID: PMO:00009569
Subclass_of: Abnormal muscle morphology
Synonym: Congenital progressive muscular dystrophy
Synonym: Dystrophic Muscle Diseases and Syndromes
Synonym: Dystrophic muscle disease or syndrome
Synonym: Dystrophies, Muscular
Synonym: Dystrophy (Muscular)
Synonym: Dystrophy, Muscular
Synonym: Dystrophy;muscular
Synonym: Hered prog musc dystrphy
Synonym: Hered.progres.musc.dystr. NOS
Synonym: Heredit.progres.musc.dystrophy
Tree Number: T3.17.1.10
database_cross_reference: AOD:0000005065
database_cross_reference: CCPSS:0046013
database_cross_reference: CHV:0000008362
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-6662
database_cross_reference: DO:DOID:9884
database_cross_reference: HPO:HP:0003560
database_cross_reference: ICD10:G71.0
database_cross_reference: ICD10AM:G71.0
database_cross_reference: ICD10CM:G71.0
database_cross_reference: ICD9CM:359.1
database_cross_reference: ICPC2P:L99093
database_cross_reference: ICPC2P:N99007
database_cross_reference: LCH:U003066
database_cross_reference: LCH_NW:sh85088693
database_cross_reference: MDR:10019897
database_cross_reference: MDR:10028356
database_cross_reference: MDR:10028357
database_cross_reference: MEDCIN:32350
database_cross_reference: MEDLINEPLUS:335
database_cross_reference: MSH:D009136
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:359.1
database_cross_reference: NCI:C84910
database_cross_reference: NCI:OMFAQ
database_cross_reference: NCI_NICHD:C84910
database_cross_reference: NDFRT:N0000002065
database_cross_reference: OMIM:MTHU037519
database_cross_reference: PSY:15700
database_cross_reference: PSY:32610
database_cross_reference: RCD:F391.
database_cross_reference: RCD:F391z
database_cross_reference: RCD:Xa0lL
database_cross_reference: SNM:D-8020
database_cross_reference: SNM:D-8021
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:DA-51100
database_cross_reference: SNMI:DA-51200
database_cross_reference: SNOMEDCT_US:155095006
database_cross_reference: SNOMEDCT_US:193225000
database_cross_reference: SNOMEDCT_US:193236007
database_cross_reference: SNOMEDCT_US:193257004
database_cross_reference: SNOMEDCT_US:267712004
database_cross_reference: SNOMEDCT_US:44292004
database_cross_reference: SNOMEDCT_US:73297009

Elevated erythrocyte sedimentation rate
type: Class
subclass of: Abnormal erythrocyte sedimentation rate
definition: An increased erythrocyte sedimentation rate (ESR). The ESR a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.
PMOID: PMO:00003590
Subclass_of: Abnormal erythrocyte sedimentation rate
Synonym: Elevated sedimentation rate
Synonym: High ESR
Synonym: High erythrocyte sedimentation rate
Synonym: Increased erythrocyte sedimentation rate
Synonym: Raised erythrocyte sedimentation rate
Tree Number: T3.6.4.2
database_cross_reference: HPO:HP:0003565

Molybdenum cofactor deficiency
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: Absence of molybdenum cofactor(2-), a cofactor for enzymes including sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase.
PMOID: PMO:00004268
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Comb molybdoflavoprot enz def
Synonym: Comb xan ox & aldehyde ox def
Synonym: Comb xan ox & sulp ox & ald ox
Synonym: Combined molybdoflavoprotein enzyme deficiency
Synonym: Combined molybdoflavoprotein enzyme deficiency (disorder)
Synonym: Combined xanthine oxid & sulph oxid & aldehyde oxidase def
Synonym: Combined xanthine oxidase and aldehyde oxidase deficiency
Synonym: Combined xanthine oxidase and aldehyde oxidase deficiency (disorder)
Synonym: Combined xanthine oxidase and sulfite oxidase and aldehyde oxidase deficiency
Synonym: Combined xanthine oxidase and sulphite oxidase and aldehyde oxidase deficiency
Tree Number: T3.6.32
database_cross_reference: HPO:HP:0003570
database_cross_reference: MDR:10069687
database_cross_reference: MSH:C535811
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C129076
database_cross_reference: OMIM:252150
database_cross_reference: OMIM:MTHU042064
database_cross_reference: RCD:X40Ue
database_cross_reference: RCD:X40Uf
database_cross_reference: RCDAE:X40Uf
database_cross_reference: SNMI:D6-40520
database_cross_reference: SNOMEDCT_US:238008009
database_cross_reference: SNOMEDCT_US:29692004

Increased total bilirubin
type: Class
subclass of: Hyperbilirubinemia
definition: Increased concentration of total (conjugated and unconjugated) bilirubin in the blood.
PMOID: PMO:00004258
Subclass_of: Hyperbilirubinemia
Synonym: High bili total
Synonym: Increased bilirubin
Tree Number: T3.6.29.2
database_cross_reference: HPO:HP:0003573

Prolonged partial thromboplastin time
type: Class
subclass of: Abnormality of coagulation
definition: Increased time to coagulation in the partial thromboplastin time (PTT) test, a measure of the intrinsic and common coagulation pathways. Phospholipid, and activator, and calcium are mixed into an anticoagulated plasma sample, and the time is measured until a thrombus forms.
PMOID: PMO:00001212
Subclass_of: Abnormality of coagulation
Synonym: Abnormal partial thromboplastin time
Synonym: Delayed thromboplastin generation
Synonym: Partial thromboplastin time prolonged
Synonym: Prolonged activated partial thromboplastin time
Tree Number: T3.2.8.4
database_cross_reference: HPO:HP:0003645

Abnormality of glycoside metabolism
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: Abnormality of glycoside metabolism.
PMOID: PMO:00003715
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.6
database_cross_reference: HPO:HP:0003649

Reduced activity of N-acetylglucosaminyltransferase II
type: Class
subclass of: Abnormality of glycoprotein metabolism
definition: An abnormality of glycoprotein metabolism related to a decreased rate of alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity.
PMOID: PMO:00004004
Subclass_of: Abnormality of glycoprotein metabolism
Synonym: Deficient N-acetylglucosaminyltransferase II
Tree Number: T3.6.14.2
database_cross_reference: HPO:HP:0003655

Cytochrome C oxidase-negative muscle fibers
type: Class
subclass of: Muscle abnormality related to mitochondrial dysfunction
definition: An abnormally reduced activity of the enzyme cytochrome C oxidase in muscle tissue.
PMOID: PMO:00009752
Subclass_of: Muscle abnormality related to mitochondrial dysfunction
Synonym: Cytochrome c oxidase deficiency in skeletal muscle
Synonym: Decreased activity of cytochrome C oxidase in muscle tissue
Synonym: Decreased skeletal muscle cytochrome c oxidase activity
Tree Number: T3.17.15.1
database_cross_reference: HPO:HP:0003688

Limb muscle weakness
type: Class
subclass of: Abnormality of the musculature of the limbs
definition: Reduced strength and weakness of the muscles of the arms and legs.
PMOID: PMO:00002852
Subclass_of: Abnormality of the musculature of the limbs
Synonym: Limb weakness
Tree Number: T3.5.3.4
database_cross_reference: HPO:HP:0003690

Skeletal muscle hypertrophy
type: Class
subclass of: Abnormality of skeletal muscles
definition: Hypertrophy (increase in size) of muscle cells (as opposed to hyperplasia, which refers to an increase in the number of muscle cells).
PMOID: PMO:00009698
Subclass_of: Abnormality of skeletal muscles
Synonym: Hypertrophic muscles
Synonym: Increased skeletal muscle cells
Synonym: Muscle hypertrophy
Synonym: Muscular hypertrophy
Synonym: skeletal muscle hypertrophy
Tree Number: T3.17.5.2
database_cross_reference: GO:GO:0014734
database_cross_reference: HPO:HP:0003712
database_cross_reference: MTH:NOCODE

Generalized muscular appearance from birth
type: Class
subclass of: Abnormal muscle morphology
PMOID: PMO:00009566
Subclass_of: Abnormal muscle morphology
Tree Number: T3.17.1.7
database_cross_reference: HPO:HP:0003716

Firm muscles
type: Class
subclass of: Abnormal muscle morphology
PMOID: PMO:00009565
Subclass_of: Abnormal muscle morphology
Tree Number: T3.17.1.6
database_cross_reference: HPO:HP:0003725

Mitochondrial myopathy
type: Class
subclass of: Muscle abnormality related to mitochondrial dysfunction
definition: A type of myopathy associated with mitochondrial disease and characterized by findings on biopsy such as ragged red muscle fibers.
PMOID: PMO:00009755
Subclass_of: Muscle abnormality related to mitochondrial dysfunction
Synonym: MITOCHONDRIAL MYOPATHY
Synonym: MYOPATHY MITOCHONDRIAL
Synonym: MYOPATHY, MITOCHONDRIAL
Synonym: Mitochondrial Myopathies
Synonym: Mitochondrial Myopathies [Disease/Finding]
Synonym: Mitochondrial Myopathy
Synonym: Mitochondrial cytopathy
Synonym: Mitochondrial myopathy (disorder)
Synonym: Myopathies, Mitochondrial
Synonym: Ragged red myopathy
Tree Number: T3.17.15.3
database_cross_reference: CCPSS:0046266
database_cross_reference: CHV:0000017938
database_cross_reference: CSP:5000-0048
database_cross_reference: DO:DOID:699
database_cross_reference: HPO:HP:0003737
database_cross_reference: MDR:10027710
database_cross_reference: MEDCIN:337551
database_cross_reference: MSH:D017240
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C101328
database_cross_reference: NCI_NICHD:C101328
database_cross_reference: NDFRT:N0000003559
database_cross_reference: OMIM:251900
database_cross_reference: OMIM:590000
database_cross_reference: OMIM:590055
database_cross_reference: OMIM:590065
database_cross_reference: OMIM:590095
database_cross_reference: OMIM:MTHU005171
database_cross_reference: RCD:X709I
database_cross_reference: SNM:D-8077
database_cross_reference: SNMI:DA-51600
database_cross_reference: SNOMEDCT_US:16851005
database_cross_reference: SNOMEDCT_US:240096000

Increased muscle fatiguability
type: Class
subclass of: Abnormality of muscle physiology
definition: An abnormal, increased fatiguability of the musculature.
PMOID: PMO:00009615
Subclass_of: Abnormality of muscle physiology
Tree Number: T3.17.3.4
database_cross_reference: HPO:HP:0003750

Calcinosis
type: Class
subclass of: Abnormal muscle morphology
definition: Formation of calcium deposits in any soft tissue.
PMOID: PMO:00009562
Subclass_of: Abnormal muscle morphology
Synonym: CALCIFICATION PATHOL
Synonym: CALCINOSIS
Synonym: Calcification
Synonym: Calcification, Pathologic
Synonym: Calcinoses
Synonym: Calcinosis (disorder)
Synonym: Calcinosis [Disease/Finding]
Synonym: Calcium Deposit(s)
Synonym: Deposit(s), Calcium
Synonym: PATHOL CALCIFICATION
Tree Number: T3.17.1.3
database_cross_reference: CHV:0000002286
database_cross_reference: CSP:0531-6043
database_cross_reference: CSP:0531-6510
database_cross_reference: CST:CALCIUM DIS
database_cross_reference: DO:DOID:182
database_cross_reference: HPO:HP:0003761
database_cross_reference: MDR:10006938
database_cross_reference: MDR:10051103
database_cross_reference: MSH:D002114
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3672
database_cross_reference: NCI_FDA:1758
database_cross_reference: NCI_NCI-GLOSS:CDR0000044317
database_cross_reference: NCI_NCI-GLOSS:CDR0000638201
database_cross_reference: NCI_NCI-GLOSS:CDR0000655127
database_cross_reference: NDFRT:N0000000644
database_cross_reference: RCD:X40QV
database_cross_reference: RCD:XC06a
database_cross_reference: SNM:M-55500
database_cross_reference: SNM:U000352
database_cross_reference: SNMI:D6-34730
database_cross_reference: SNOMEDCT_US:190863003
database_cross_reference: SNOMEDCT_US:237881004
database_cross_reference: SNOMEDCT_US:6595006

Externally rotated/abducted legs
type: Class
subclass of: Abnormality of the lower limb
PMOID: PMO:00002825
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.8
database_cross_reference: HPO:HP:0003783

Muscle abnormality related to mitochondrial dysfunction
type: Class
subclass of: Abnormality of the musculature
PMOID: PMO:00009751
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.15
database_cross_reference: HPO:HP:0003800

Abnormal muscle tone
type: Class
subclass of: Abnormality of muscle physiology
PMOID: PMO:00009591
Subclass_of: Abnormality of muscle physiology
Synonym: Abnormal muscles tone
Synonym: Muscle tone abnormal
Tree Number: T3.17.3.1
database_cross_reference: HPO:HP:0003808
database_cross_reference: MDR:10028342
database_cross_reference: OMIM:MTHU052933

Abnormality of the abdominal wall
type: Class
subclass of: Abnormality of the digestive system
definition: The presence of any abnormality affecting the abdominal wall.
PMOID: PMO:00005541
Subclass_of: Abnormality of the digestive system
Synonym: Abnormality of external features of the abdomen
Tree Number: T3.10.5
database_cross_reference: HPO:HP:0004298

Hernia of the abdominal wall
type: Class
subclass of: Hernia
definition: The presence of a hernia in the abdominal wall.
PMOID: PMO:00001355
Subclass_of: Hernia
Synonym: External abdominal hernia
Synonym: Hernia abdominal wall
Synonym: Hernia of abdominal wall
Synonym: Hernia of abdominal wall (disorder)
Synonym: hernia of abdominal wall (diagnosis)
Tree Number: T3.3.7.3
database_cross_reference: HPO:HP:0004299
database_cross_reference: MDR:10019911
database_cross_reference: MEDCIN:360857
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:128545000

Functional motor deficit
type: Class
subclass of: Abnormality of muscle physiology
PMOID: PMO:00009609
Subclass_of: Abnormality of muscle physiology
Synonym: Functional motor problems
Tree Number: T3.17.3.3
database_cross_reference: HPO:HP:0004302

Abnormality of muscle fibers
type: Class
subclass of: Abnormal muscle morphology
definition: Any abnormality of the skeletal muscle cell. Muscle fibers are subdivided into two types. Type I fibers are fatigue-resistant and rich in oxidative enzymes (they stain light with the myosin ATPase reaction), and type II fibers are fast-contracting, fatigue-prone, and rich in glycolytic enzymes (these fibers stain darkly). Normal muscle tissue has a random distribution of type I and type II fibers.
PMOID: PMO:00009458
Subclass_of: Abnormal muscle morphology
Synonym: Abnormal skeletal muscle fiber morphology
Tree Number: T3.17.1.1
database_cross_reference: HPO:HP:0004303

Abnormality of reticulocytes
type: Class
subclass of: Abnormal erythrocyte morphology
definition: A reticulocyte abnormality.
PMOID: PMO:00000961
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.9
database_cross_reference: HPO:HP:0004312

Bladder fistula
type: Class
subclass of: Urogenital fistula
definition: The presence of a fistula connecting the urinary bladder to another organ or the skin. The fistula can involve the bowel, the vagina, or rarely, the skin.
PMOID: PMO:00008243
Subclass_of: Urogenital fistula
Synonym: BLADDER FISTULA
Synonym: Bladder Fistula
Synonym: Bladder fistula (disorder)
Synonym: Bladder fistula, NOS
Synonym: FISTULA, BLADDER
Synonym: Fistula - vesical
Synonym: Fistula, Urinary Bladder
Synonym: Fistula, Vesical
Synonym: Fistula, bladder NOS
Synonym: Fistulas, Urinary Bladder
Tree Number: T3.14.4.1
database_cross_reference: CHV:0000001954
database_cross_reference: DXP:U000378
database_cross_reference: DXP:U000663
database_cross_reference: HPO:HP:0004321
database_cross_reference: MDR:10047363
database_cross_reference: MDR:10051263
database_cross_reference: MEDCIN:330475
database_cross_reference: MEDCIN:96706
database_cross_reference: MSH:D001747
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:596.2
database_cross_reference: NCI:C79849
database_cross_reference: NCI_NICHD:C79849
database_cross_reference: NDFRT:N0000000562
database_cross_reference: RCD:X30OX
database_cross_reference: SNMI:D7-21500
database_cross_reference: SNOMEDCT_US:155890000
database_cross_reference: SNOMEDCT_US:266630005
database_cross_reference: SNOMEDCT_US:68666001

Short stature
type: Class
subclass of: Abnormality of body height
definition: A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).
PMOID: PMO:00014120
Subclass_of: Abnormality of body height
Synonym: Constitutional dwarfism
Synonym: Constitutional short stature
Synonym: Constitutional short stature (disorder)
Synonym: DWARF
Synonym: DWARFISM
Synonym: Decreased body height
Synonym: Dwarf
Synonym: Dwarf, NOS
Synonym: Dwarfism
Synonym: Dwarfism (disorder)
Tree Number: T3.24.1.2
database_cross_reference: CCPSS:0056989
database_cross_reference: CHV:0000004192
database_cross_reference: CHV:0000037167
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2715-1516
database_cross_reference: CST:DWARFISM
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0003510
database_cross_reference: HPO:HP:0004322
database_cross_reference: ICD10CM:E34.3
database_cross_reference: ICPC2P:T80002
database_cross_reference: LCH:U001480
database_cross_reference: LCH_NW:sh85040186
database_cross_reference: MDR:10013881
database_cross_reference: MDR:10013883
database_cross_reference: MDR:10013884
database_cross_reference: MDR:10028707
database_cross_reference: MDR:10039297
database_cross_reference: MEDCIN:273623
database_cross_reference: MEDCIN:37615
database_cross_reference: MEDLINEPLUS:1244
database_cross_reference: MSH:D004392
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:259.4
database_cross_reference: NCI:C34554
database_cross_reference: NCI_NICHD:C34554
database_cross_reference: NDFRT:N0000001012
database_cross_reference: OMIM:MTHU003184
database_cross_reference: OMIM:MTHU009274
database_cross_reference: OMIM:MTHU011485
database_cross_reference: RCD:C1z41
database_cross_reference: RCD:R0346
database_cross_reference: RCD:X40Oq
database_cross_reference: RCD:X40Or
database_cross_reference: RCDSY:R0346
database_cross_reference: SNM:M-70120
database_cross_reference: SNMI:DB-00200
database_cross_reference: SNOMEDCT_US:185797004
database_cross_reference: SNOMEDCT_US:190584003
database_cross_reference: SNOMEDCT_US:190585002
database_cross_reference: SNOMEDCT_US:205467007
database_cross_reference: SNOMEDCT_US:206931003
database_cross_reference: SNOMEDCT_US:237836003
database_cross_reference: SNOMEDCT_US:237837007
database_cross_reference: SNOMEDCT_US:248299001
database_cross_reference: SNOMEDCT_US:422065006
database_cross_reference: SNOMEDCT_US:90482002
database_cross_reference: SNOMEDCT_VET:237837007

Abnormality of body weight
type: Class
subclass of: Growth abnormality
definition: An abnormal increase or decrease of weight or an abnormal distribution of mass in the body.
PMOID: PMO:00014145
Subclass_of: Growth abnormality
Tree Number: T3.24.2
database_cross_reference: HPO:HP:0004323

Increased body weight
type: Class
subclass of: Abnormality of body weight
definition: Abnormally increased body weight.
PMOID: PMO:00014161
Subclass_of: Abnormality of body weight
Tree Number: T3.24.2.4
database_cross_reference: HPO:HP:0004324

Decreased body weight
type: Class
subclass of: Abnormality of body weight
PMOID: PMO:00014151
Subclass_of: Abnormality of body weight
Synonym: Decreased weight
Synonym: Low body weight
Synonym: Low weight
Synonym: Weight less than 3rd percentile
Tree Number: T3.24.2.3
database_cross_reference: HPO:HP:0004325

Abnormal anterior segment morphology
type: Class
subclass of: Abnormal eye morphology
definition: An abnormality of the anterior segment of the eyeball (which comprises the structures in front of the vitreous humour: the cornea, iris, ciliary body, and lens).
PMOID: PMO:00006421
Subclass_of: Abnormal eye morphology
Tree Number: T3.13.1.1

Abnormal morphology of the posterior segment of the globe
type: Class
subclass of: Abnormal eye morphology
PMOID: PMO:00006591
Subclass_of: Abnormal eye morphology
Tree Number: T3.13.1.2

Abnormality of amino acid metabolism
type: Class
subclass of: Abnormality of carboxylic acid metabolism
definition: Abnormality of an amino acid metabolic process.
PMOID: PMO:00003764
Subclass_of: Abnormality of carboxylic acid metabolism
Tree Number: T3.6.11.1
database_cross_reference: HPO:HP:0004337

Abnormality of vitamin B metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
PMOID: PMO:00004204
Subclass_of: Abnormality of vitamin metabolism
Synonym: Abnormality of B-vitamin metabolism
Tree Number: T3.6.23.2
database_cross_reference: HPO:HP:0004340

Abnormality of purine metabolism
type: Class
subclass of: Abnormality of nucleobase metabolism
PMOID: PMO:00004166
Subclass_of: Abnormality of nucleobase metabolism
Tree Number: T3.6.19.1
database_cross_reference: HPO:HP:0004352

Abnormality of pyrimidine metabolism
type: Class
subclass of: Abnormality of nucleobase metabolism
definition: An abnormality of a pyrimidine base metabolic process.
PMOID: PMO:00004177
Subclass_of: Abnormality of nucleobase metabolism
Tree Number: T3.6.19.2
database_cross_reference: HPO:HP:0004353

Abnormality of carboxylic acid metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality of the metabolism of a carboxylic acid.
PMOID: PMO:00003763
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.11
database_cross_reference: HPO:HP:0004354

Abnormality of proteoglycan metabolism
type: Class
subclass of: Abnormality of glycoprotein metabolism
definition: An abnormality of proteoglycan metabolism.
PMOID: PMO:00004002
Subclass_of: Abnormality of glycoprotein metabolism
Tree Number: T3.6.14.1
database_cross_reference: HPO:HP:0004355

Abnormality of lysosomal metabolism
type: Class
subclass of: Abnormal cellular physiology
PMOID: PMO:00003493
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.6
database_cross_reference: HPO:HP:0004356

Abnormality of superoxide metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
PMOID: PMO:00004183
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.20
database_cross_reference: HPO:HP:0004358

Abnormality of fatty-acid metabolism
type: Class
subclass of: Abnormality of lipid metabolism
definition: An abnormality of fatty acid metabolism.
PMOID: PMO:00004096
Subclass_of: Abnormality of lipid metabolism
Synonym: Abnormality of fatty acid metabolism
Tree Number: T3.6.17.3
database_cross_reference: HPO:HP:0004359

Abnormality of acid-base homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH.
PMOID: PMO:00003598
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.8
database_cross_reference: HPO:HP:0004360

Abnormality of circulating leptin level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An abnormal concentration of leptin in the blood.
PMOID: PMO:00006185
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.15
database_cross_reference: HPO:HP:0004361

Abnormality of nitrogen compound homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: The presence of an abnormal concentration of nitrogen compounds.
PMOID: PMO:00004138
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.18
database_cross_reference: HPO:HP:0004364

Abnormality of glycolysis
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An abnormality of glycolysis.
PMOID: PMO:00003712
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.5
database_cross_reference: HPO:HP:0004366

Abnormality of glycoprotein metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality of a glycoprotein metabolic process.
PMOID: PMO:00004001
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.14
database_cross_reference: HPO:HP:0004367

Abnormality of temperature regulation
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality of temperature homeostasis.
PMOID: PMO:00004185
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.21

Neoplasm of the nervous system
type: Class
subclass of: Abnormality of nervous system morphology
definition: A tumor (abnormal growth of tissue) of the nervous system.
PMOID: PMO:00010524
Subclass_of: Abnormality of nervous system morphology
Synonym: NEOPL NERVOUS SYSTEM
Synonym: NERVOUS SYSTEM NEOPL
Synonym: Neoplasia of the nervous system
Synonym: Neoplasm of Nervous System
Synonym: Neoplasm of nervous system
Synonym: Neoplasm of nervous system (disorder)
Synonym: Neoplasm of the Nervous System
Synonym: Neoplasm, Nervous System
Synonym: Neoplasms, Nervous System
Synonym: Nervous System Neoplasm
Tree Number: T3.18.2.5
database_cross_reference: AOD:0000004643
database_cross_reference: AOD:0000023105
database_cross_reference: CHV:0000008607
database_cross_reference: CHV:0000049245
database_cross_reference: CSP:2012-5157
database_cross_reference: HPO:HP:0004375
database_cross_reference: LCH_NW:sh00008550
database_cross_reference: LCH_NW:sh85090936
database_cross_reference: MDR:10029208
database_cross_reference: MDR:10061311
database_cross_reference: MSH:D009423
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3268
database_cross_reference: NCI_NICHD:C3268
database_cross_reference: NDFRT:N0000002160
database_cross_reference: PSY:33550
database_cross_reference: RCD:X78Zk
database_cross_reference: RCDAE:X78Zk
database_cross_reference: SNOMEDCT_US:126950007

Hematological neoplasm
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue).
PMOID: PMO:00001215
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: Blood cancer
Synonym: Blood tumor
Synonym: Carcinoma;blood
Synonym: Carcinoma;bone;marrow
Synonym: HEMATOL MALIGNANCIES
Synonym: HEMATOL MALIGNANCY
Synonym: HEMATOL NEOPL
Synonym: Haematologic malignancy
Synonym: Haematologic neoplasm
Synonym: Haematological malignancy
Tree Number: T3.2.10
database_cross_reference: CHV:0000031196
database_cross_reference: CHV:0000031810
database_cross_reference: CHV:0000049723
database_cross_reference: CSP:2004-0139
database_cross_reference: HPO:HP:0001909
database_cross_reference: HPO:HP:0004377
database_cross_reference: ICPC2P:B74010
database_cross_reference: ICPC2P:B74011
database_cross_reference: MDR:10066476
database_cross_reference: MDR:10066481
database_cross_reference: MSH:D019337
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C27134
database_cross_reference: NCI_NCI-GLOSS:CDR0000045708
database_cross_reference: NDFRT:N0000003918
database_cross_reference: PDQ:CDR0000039800
database_cross_reference: SNOMEDCT_US:127221002
database_cross_reference: SNOMEDCT_US:129154003
database_cross_reference: SNOMEDCT_US:269475001

Abnormality of alkaline phosphatase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: An abnormality of alkaline phosphatase activity.
PMOID: PMO:00003562
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.8
database_cross_reference: HPO:HP:0004379

Prune belly
type: Class
subclass of: Abnormality of the abdominal wall
definition: A kind of congenital defect of the anterior abdominal wall in which the intestines are evident through the thin, lax, and protruding abdominal wall in affected infants.
PMOID: PMO:00005560
Subclass_of: Abnormality of the abdominal wall
Tree Number: T3.10.5.5
database_cross_reference: HPO:HP:0004392

Abnormal nipple morphology
type: Class
subclass of: Abnormal breast morphology
definition: An abnormality of the nipple.
PMOID: PMO:00004417
Subclass_of: Abnormal breast morphology
Synonym: Abnormality of the nipple
Tree Number: T3.8.1.1
database_cross_reference: HPO:HP:0004404

Arterial thrombosis
type: Class
subclass of: Abnormal thrombosis
definition: The formation of a blood clot inside an artery.
PMOID: PMO:00001104
Subclass_of: Abnormal thrombosis
Synonym: ARTERIAL THROMBOSIS
Synonym: Arterial Thrombosis
Synonym: Arterial thrombosis (disorder)
Synonym: Arterial thrombosis NOS
Synonym: Arterial thrombosis, NOS, of unspecified artery
Synonym: Blood clot in artery
Synonym: THROMBOSIS ARTERIAL
Synonym: Thrombosis - arterial
Synonym: Thrombosis arterial
Synonym: Thrombosis;arterial
Tree Number: T3.2.6.1
database_cross_reference: CCPSS:0033511
database_cross_reference: CHV:0000017111
database_cross_reference: CST:PATHTROMBART
database_cross_reference: CST:THROM ART
database_cross_reference: HPO:HP:0004420
database_cross_reference: ICPC2P:K92014
database_cross_reference: MDR:10003178
database_cross_reference: MDR:10003181
database_cross_reference: MDR:10043611
database_cross_reference: MEDCIN:236660
database_cross_reference: NCI:C98826
database_cross_reference: NCI_NICHD:C98826
database_cross_reference: OMIM:MTHU015923
database_cross_reference: RCD:X203s
database_cross_reference: SNMI:D3-81500
database_cross_reference: SNOMEDCT_US:195315009
database_cross_reference: SNOMEDCT_US:65198009

Poikilocytosis
type: Class
subclass of: Abnormal erythrocyte morphology
definition: The presence of abnormally shaped erythrocytes.
PMOID: PMO:00001014
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.15
database_cross_reference: HPO:HP:0004447

Decreased cervical spine flexion due to contractures of posterior cervical muscles
type: Class
subclass of: Flexion contracture
PMOID: PMO:00001320
Subclass_of: Flexion contracture
Synonym: Contracture of post-cervical muscles
Tree Number: T3.3.6.3
database_cross_reference: HPO:HP:0004631

Increased hemoglobin oxygen affinity
type: Class
subclass of: Abnormal erythrocyte physiology
definition: An abnormal increase in the binding affinity of hemoglobin for oxygen.
PMOID: PMO:00001032
Subclass_of: Abnormal erythrocyte physiology
Synonym: Increased haemoglobin oxygen affinity
Tree Number: T3.2.3.1
database_cross_reference: HPO:HP:0004825

Perineal fistula
type: Class
subclass of: Urogenital fistula
definition: The presence of a fistula between the bowel and the perineum.
PMOID: PMO:00008245
Subclass_of: Urogenital fistula
Synonym: Perineal fistula (disorder)
Synonym: fistulas perineal
Synonym: perineal fistula
Tree Number: T3.14.4.2
database_cross_reference: CHV:0000039767
database_cross_reference: HPO:HP:0004871
database_cross_reference: MDR:10056556
database_cross_reference: OMIM:MTHU013659
database_cross_reference: RCD:Xa2b8
database_cross_reference: SNOMEDCT_US:284077005

Maturity-onset diabetes of the young
type: Class
subclass of: Diabetes mellitus
definition: The term Maturity-onset diabetes of the young (MODY) was initially used for patients diagnosed with fasting hyperglycemia that could be treated without insulin for more than two years, where the initial diagnosis was made at a young age (under 25 years). Thus, MODY combines characteristics of type 1 diabetes (young age at diagnosis) and type 2 diabetes (less insulin dependence than type 1 diabetes). The term MODY is now most often used to refer to a group of monogenic diseases with these characteristics. Here, the term is used to describe hyperglycemia diagnosed at a young age with no or minor insulin dependency, no evidence of insulin resistence, and lack of evidence of autoimmune destruction of the beta cells.
PMOID: PMO:00006368
Subclass_of: Diabetes mellitus
Synonym: Autosomal dominant diabetes mellitus
Synonym: Diab mell aut dom
Synonym: Diabetes mellitus autosomal dominant
Synonym: Diabetes mellitus autosomal dominant (disorder)
Synonym: Diabetes, maturity-onset, of the young (MODY)
Synonym: MASON-TYPE DIABETES
Synonym: MATURITY-ONSET DIABETES OF THE YOUNG
Synonym: MODY
Synonym: MODY - Maturity onset diabetes in youth type 1
Synonym: MODY - Maturity onset diabetes in youth type I
Tree Number: T3.12.13.3
database_cross_reference: CHV:0000030749
database_cross_reference: DO:DOID:0050524
database_cross_reference: HPO:HP:0004904
database_cross_reference: MDR:10026948
database_cross_reference: MEDCIN:358414
database_cross_reference: MSH:C562772
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C114769
database_cross_reference: OMIM:606391
database_cross_reference: OMIM:MTHU039842
database_cross_reference: RCD:X40JI
database_cross_reference: SNMI:DB-61040
database_cross_reference: SNOMEDCT_US:28453007
database_cross_reference: SNOMEDCT_US:390715006
database_cross_reference: SNOMEDCT_US:400971001
database_cross_reference: SNOMEDCT_US:609561005

Impairment of galactose metabolism
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An impairment of galactose metabolism.
PMOID: PMO:00003740
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Impaired galactose metabolism
Tree Number: T3.6.10.15
database_cross_reference: HPO:HP:0004915

Abnormality of the pulmonary vasculature
type: Class
subclass of: Abnormality of the vasculature
PMOID: PMO:00005276
Subclass_of: Abnormality of the vasculature
Synonym: Abnormality of the lung blood vessels
Tree Number: T3.9.5.2
database_cross_reference: HPO:HP:0004930

Venous thrombosis
type: Class
subclass of: Abnormal thrombosis
definition: Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow.
PMOID: PMO:00001112
Subclass_of: Abnormal thrombosis
Synonym: Blood clot in vein
Synonym: PHLEBOTHROMBOSIS
Synonym: Phlebothromboses
Synonym: Phlebothrombosis
Synonym: Phlebothrombosis (disorder)
Synonym: Phlebothrombosis, NOS
Synonym: THROMBOSIS VENOUS
Synonym: Thromboses, Venous
Synonym: Thrombosis (vein) NOS
Synonym: Thrombosis of vein NOS
Tree Number: T3.2.6.5
database_cross_reference: CCPSS:0008959
database_cross_reference: CHV:0000012947
database_cross_reference: CHV:0000037596
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:0571-8485
database_cross_reference: CST:PATHTHROMBVEN
database_cross_reference: CST:THROMBOPHLEB
database_cross_reference: DXP:U004370
database_cross_reference: HPO:HP:0004936
database_cross_reference: ICD10CM:I82.90
database_cross_reference: ICPC2P:K94008
database_cross_reference: MDR:10034904
database_cross_reference: MDR:10043640
database_cross_reference: MDR:10047249
database_cross_reference: MDR:10047253
database_cross_reference: MEDCIN:38214
database_cross_reference: MEDLINEPLUS:1683
database_cross_reference: MEDLINEPLUS:6076
database_cross_reference: MSH:D020246
database_cross_reference: MTH:U002301
database_cross_reference: MTHICD9:453.9
database_cross_reference: NCI:C99107
database_cross_reference: NCI_NICHD:C99107
database_cross_reference: NDFRT:N0000004074
database_cross_reference: OMIM:188050
database_cross_reference: OMIM:MTHU002871
database_cross_reference: RCD:XE0Vb
database_cross_reference: RCD:Xa0l8
database_cross_reference: SNM:M-35190
database_cross_reference: SNMI:D3-87004
database_cross_reference: SNMI:D3-87500
database_cross_reference: SNOMEDCT_US:111293003
database_cross_reference: SNOMEDCT_US:155458001
database_cross_reference: SNOMEDCT_US:18266009
database_cross_reference: SNOMEDCT_US:195442006
database_cross_reference: SNOMEDCT_US:266269008

Duplication of internal organs
type: Class
subclass of: Abnormality of abdomen morphology
PMOID: PMO:00005307
Subclass_of: Abnormality of abdomen morphology
Tree Number: T3.10.1.4
database_cross_reference: HPO:HP:0005217

Premature delivery because of cervical insufficiency or membrane fragility
type: Class
subclass of: Premature birth
PMOID: PMO:00004382
Subclass_of: Premature birth
Tree Number: T3.7.10.1
database_cross_reference: HPO:HP:0005267

Spontaneous abortion
type: Class
subclass of: Abnormal delivery
definition: A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 20th week of pregnancy.
PMOID: PMO:00004308
Subclass_of: Abnormal delivery
Synonym: ABORTION SPONTANEOUS
Synonym: ABORTION, SPONTANEOUS
Synonym: Abortion (Spontaneous)
Synonym: Abortion - spontaneous
Synonym: Abortion spontaneous
Synonym: Abortion spontaneous NOS
Synonym: Abortion, Spontaneous
Synonym: Abortion, Spontaneous [Disease/Finding]
Synonym: Abortion, spontaneous
Synonym: Abortion;spontaneous
Tree Number: T3.7.1.9
database_cross_reference: AOD:0000004923
database_cross_reference: AOD:0000023198
database_cross_reference: CCPSS:0043536
database_cross_reference: CHV:0000000546
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000638
database_cross_reference: CSP:2404-4325
database_cross_reference: CST:ABORTION
database_cross_reference: DO:DOID:722
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000006
database_cross_reference: HPO:HP:0005268
database_cross_reference: ICD10:O03
database_cross_reference: ICD10AM:O03
database_cross_reference: ICD10CM:O03
database_cross_reference: ICD10CM:O03.9
database_cross_reference: ICD9CM:634
database_cross_reference: ICPC2EENG:W82
database_cross_reference: ICPC2P:W82001
database_cross_reference: ICPC2P:W82004
database_cross_reference: LCH_NW:sh85085974
database_cross_reference: LNC:LA14272-1
database_cross_reference: LNC:MTHU002836
database_cross_reference: MDR:10000234
database_cross_reference: MDR:10000235
database_cross_reference: MDR:10000241
database_cross_reference: MDR:10027649
database_cross_reference: MDR:10027650
database_cross_reference: MDR:10041687
database_cross_reference: MEDCIN:30604
database_cross_reference: MEDLINEPLUS:515
database_cross_reference: MSH:D000022
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:761.8
database_cross_reference: NCI:C34336
database_cross_reference: NCI_FDA:1962
database_cross_reference: NCI_GAIA:C34336
database_cross_reference: NCI_NICHD:C34336
database_cross_reference: NDFRT:N0000000268
database_cross_reference: PSY:00100
database_cross_reference: PSY:31670
database_cross_reference: PSY:49350
database_cross_reference: RCD:L04..
database_cross_reference: RCD:L040.
database_cross_reference: RCD:L040z
database_cross_reference: RCD:L04z.
database_cross_reference: SNM:F-31600
database_cross_reference: SNM:F-31680
database_cross_reference: SNMI:D8-04100
database_cross_reference: SNOMEDCT_US:156071003
database_cross_reference: SNOMEDCT_US:156074006
database_cross_reference: SNOMEDCT_US:17369002
database_cross_reference: SNOMEDCT_US:198631006
database_cross_reference: SNOMEDCT_US:198643007
database_cross_reference: SNOMEDCT_US:198689000
database_cross_reference: SNOMEDCT_US:267294003

Abnormality of humoral immunity
type: Class
subclass of: Abnormality of immune system physiology
definition: An abnormality of the humoral immune system, which comprises antibodies produced by B cells as well as the complement system.
PMOID: PMO:00008527
Subclass_of: Abnormality of immune system physiology
Synonym: Defective humoral immunity
Tree Number: T3.15.2.5
database_cross_reference: HPO:HP:0005368

Increased red cell osmotic fragility
type: Class
subclass of: Abnormal erythrocyte physiology
PMOID: PMO:00001033
Subclass_of: Abnormal erythrocyte physiology
Synonym: Increased erythrocyte osmotic fragility
Synonym: Increased red cell fragility
Tree Number: T3.2.3.2
database_cross_reference: HPO:HP:0005502

Disseminated intravascular coagulation
type: Class
subclass of: Abnormal thrombosis
definition: Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels.
PMOID: PMO:00001105
Subclass_of: Abnormal thrombosis
Synonym: COAG DISSEM INTRAVASC
Synonym: CONSUMPTION COAGULOPATHY
Synonym: Coagulation (DIC), Disseminated Intravascular
Synonym: Coagulation, Disseminated Intravascular
Synonym: Coagulation, Intravascular Disseminated
Synonym: Coagulations, Disseminated Intravascular
Synonym: Coagulations, Intravascular Disseminated
Synonym: Coagulopathies, Consumption
Synonym: Coagulopathy, Consumption
Synonym: Consumption Coagulopathies
Tree Number: T3.2.6.2
database_cross_reference: CCPSS:1013555
database_cross_reference: CHV:0000004034
database_cross_reference: CSP:0438-8377
database_cross_reference: CST:DIC
database_cross_reference: CST:PATHDIC
database_cross_reference: DO:DOID:0060538
database_cross_reference: DO:DOID:11247
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000486
database_cross_reference: HPO:HP:0005521
database_cross_reference: ICD10:D65
database_cross_reference: ICD10AM:D65
database_cross_reference: ICD10CM:D65
database_cross_reference: ICD9CM:286.6
database_cross_reference: ICPC2P:B83017
database_cross_reference: LCH:U001430
database_cross_reference: LCH_NW:sh85038487
database_cross_reference: MDR:10010785
database_cross_reference: MDR:10010786
database_cross_reference: MDR:10012126
database_cross_reference: MDR:10012769
database_cross_reference: MDR:10013429
database_cross_reference: MDR:10013441
database_cross_reference: MDR:10013442
database_cross_reference: MEDCIN:30388
database_cross_reference: MEDCIN:96948
database_cross_reference: MSH:D004211
database_cross_reference: MTH:U001871
database_cross_reference: MTHICD9:286.6
database_cross_reference: NCI:C2992
database_cross_reference: NCI_FDA:1813
database_cross_reference: NCI_NICHD:C2992
database_cross_reference: NDFRT:N0000000985
database_cross_reference: OMIM:MTHU021343
database_cross_reference: RCD:D306.
database_cross_reference: SNM:D-4411
database_cross_reference: SNMI:DC-60020
database_cross_reference: SNOMEDCT_US:267563002
database_cross_reference: SNOMEDCT_US:67406007

Lymphoproliferative disorder
type: Class
subclass of: Hematological neoplasm
PMOID: PMO:00001250
Subclass_of: Hematological neoplasm
Synonym: Disorder, Lymphoproliferative
Synonym: Disorders, Lymphoproliferative
Synonym: Duncan syndrome
Synonym: Duncan's syndrome
Synonym: LYMPHOPROLIFERATIVE DIS
Synonym: Lymphoproliferative Disorder
Synonym: Lymphoproliferative Disorders
Synonym: Lymphoproliferative Disorders [Disease/Finding]
Synonym: Lymphoproliferative disease
Synonym: Lymphoproliferative disease (morphologic abnormality)
Tree Number: T3.2.10.3
database_cross_reference: CHV:0000007624
database_cross_reference: DO:DOID:619
database_cross_reference: HPO:HP:0005523
database_cross_reference: ICD10AM:M9970/1
database_cross_reference: ICD10CM:D47.9
database_cross_reference: LCH:U002767
database_cross_reference: LCH_NW:sh85079155
database_cross_reference: MDR:10025351
database_cross_reference: MDR:10061232
database_cross_reference: MDR:10068350
database_cross_reference: MEDCIN:312073
database_cross_reference: MSH:D008232
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C9308
database_cross_reference: NCI_NCI-GLOSS:CDR0000045767
database_cross_reference: NDFRT:N0000001914
database_cross_reference: OMIM:MTHU038984
database_cross_reference: RCD:X20Ik
database_cross_reference: RCD:Xa0QI
database_cross_reference: SNM:M-9969/1
database_cross_reference: SNMI:M-99701
database_cross_reference: SNOMEDCT_US:277466009
database_cross_reference: SNOMEDCT_US:414629003
database_cross_reference: SNOMEDCT_US:77121009
database_cross_reference: SNOMEDCT_US:84631004

Prolonged whole-blood clotting time
type: Class
subclass of: Abnormality of coagulation
definition: An abnormal prolongation (delay) in the time required by whole blood to produce a visible clot.
PMOID: PMO:00001213
Subclass_of: Abnormality of coagulation
Synonym: Prolonged clotting time
Tree Number: T3.2.8.5
database_cross_reference: HPO:HP:0005542

Increased red cell osmotic resistance
type: Class
subclass of: Abnormal erythrocyte physiology
PMOID: PMO:00001034
Subclass_of: Abnormal erythrocyte physiology
Tree Number: T3.2.3.3
database_cross_reference: HPO:HP:0005546

Abnormality of the kinin-kallikrein system
type: Class
subclass of: Abnormality of circulating protein level
PMOID: PMO:00003958
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.12
database_cross_reference: HPO:HP:0005559

Abnormality of bone marrow cell morphology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: An anomaly of the form or number of cells in the bone marrow.
PMOID: PMO:00001123
Subclass_of: Abnormality of blood and blood-forming tissues
Synonym: Anomaly of the bone marrow cells
Tree Number: T3.2.7
database_cross_reference: HPO:HP:0005561

Intervertebral disk calcification
type: Class
subclass of: Ectopic calcification
definition: The presence of abnormal calcium deposition of the intervertebral disk.
PMOID: PMO:00014010
Subclass_of: Ectopic calcification
Synonym: Interverteb disk calcification
Synonym: Intervertebral disc calcification
Synonym: Intervertebral disk calcification (disorder)
Synonym: Intervertebral disk mineralized
Synonym: Multiple intervertebral disk calcifications
Tree Number: T3.20.4.6
database_cross_reference: HPO:HP:0005645
database_cross_reference: MDR:10055038
database_cross_reference: RCD:X70Ce
database_cross_reference: SNOMEDCT_US:240211000
database_cross_reference: SNOMEDCT_VET:240211000

Contractures of the large joints
type: Class
subclass of: Flexion contracture
PMOID: PMO:00001319
Subclass_of: Flexion contracture
Tree Number: T3.3.6.2
database_cross_reference: HPO:HP:0005781

Progressive flexion contractures
type: Class
subclass of: Flexion contracture
definition: Progressively worsening joint contractures.
PMOID: PMO:00001347
Subclass_of: Flexion contracture
Synonym: Joint contractures, progressive
Tree Number: T3.3.6.8
database_cross_reference: HPO:HP:0005876

Imperfect vocal cord adduction
type: Class
subclass of: Vocal cord dysfunction
PMOID: PMO:00014039
Subclass_of: Vocal cord dysfunction
Tree Number: T3.22.11.1
database_cross_reference: HPO:HP:0005934

Decreased pulmonary function
type: Class
subclass of: Functional respiratory abnormality
PMOID: PMO:00011635
Subclass_of: Functional respiratory abnormality
Synonym: DEPRESSION RESPIRATORY
Synonym: Decreased lung function
Synonym: Decreased respiration
Synonym: Decreased respiratory function
Synonym: Decreased respiratory function (finding)
Synonym: Depression respiratory
Synonym: Depressions, Ventilatory
Synonym: FUNCTION PULMONARY DECREASED
Synonym: Function pulmonary decreased
Synonym: LUNG FUNCTION DECREASED
Tree Number: T3.19.2.15
database_cross_reference: CCPSS:0017150
database_cross_reference: CCPSS:1016342
database_cross_reference: CHV:0000022793
database_cross_reference: CHV:0000023445
database_cross_reference: CST:HYPOVENTIL
database_cross_reference: CST:LUNG FUNC DEC
database_cross_reference: HPO:HP:0002791
database_cross_reference: HPO:HP:0005952
database_cross_reference: MDR:10012396
database_cross_reference: MDR:10017477
database_cross_reference: MDR:10025093
database_cross_reference: MDR:10025094
database_cross_reference: MDR:10038650
database_cross_reference: MDR:10038678
database_cross_reference: MSH:D012131
database_cross_reference: NCI:C116314
database_cross_reference: NCI_NICHD:C116314
database_cross_reference: SNM:F-75004
database_cross_reference: SNMI:F-20004
database_cross_reference: SNOMEDCT_US:80954004

Breathing dysregulation
type: Class
subclass of: Functional respiratory abnormality
PMOID: PMO:00011628
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal breathing
Synonym: Breathing difficulty
Synonym: Difficult to breathe
Tree Number: T3.19.2.13
database_cross_reference: HPO:HP:0005957

Temperature instability
type: Class
subclass of: Abnormality of temperature regulation
definition: Disordered thermoregulation characterized by an impaired ability to maintain a balance between heat production and heat loss, with resulting instability of body temperature.
PMOID: PMO:00004195
Subclass_of: Abnormality of temperature regulation
Tree Number: T3.6.21.6
database_cross_reference: HPO:HP:0005968

Type II diabetes mellitus
type: Class
subclass of: Diabetes mellitus
definition: A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia.
PMOID: PMO:00006370
Subclass_of: Diabetes mellitus
Synonym: -- Diabetes Type 2
Synonym: ADULT ONSET DIABETES MELLITUS
Synonym: AODM
Synonym: Adult Onset Diabetes
Synonym: Adult-Onset Diabetes
Synonym: Adult-Onset Diabetes Mellitus
Synonym: DIABETES MELLITUS (ADULT ONSET)
Synonym: DIABETES MELLITUS NON INSULIN DEPENDENT
Synonym: DIABETES MELLITUS NOS LATE ONSET
Synonym: DIABETES MELLITUS TYPE 02
Tree Number: T3.12.13.5
database_cross_reference: BI:BI00333
database_cross_reference: BI:BI00336
database_cross_reference: BI:BI00339
database_cross_reference: BI:BI00364
database_cross_reference: CCPSS:0045504
database_cross_reference: CCPSS:0058620
database_cross_reference: CHV:0000003837
database_cross_reference: COSTAR:U000225
database_cross_reference: CSP:0862-7250
database_cross_reference: DO:DOID:9352
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000472
database_cross_reference: HPO:HP:0005978
database_cross_reference: ICD10:E11
database_cross_reference: ICD10AM:E11
database_cross_reference: ICD10CM:E11
database_cross_reference: ICPC2EENG:T90
database_cross_reference: ICPC2P:T90005
database_cross_reference: ICPC2P:T90007
database_cross_reference: ICPC2P:T90009
database_cross_reference: LCH_NW:sh85092226
database_cross_reference: LNC:LA10552-0
database_cross_reference: MDR:10012611
database_cross_reference: MDR:10012612
database_cross_reference: MDR:10012613
database_cross_reference: MDR:10026947
database_cross_reference: MDR:10029402
database_cross_reference: MDR:10029505
database_cross_reference: MDR:10045242
database_cross_reference: MDR:10067585
database_cross_reference: MEDCIN:30480
database_cross_reference: MEDLINEPLUS:5930
database_cross_reference: MSH:D003924
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26747
database_cross_reference: NCI_NICHD:C26747
database_cross_reference: NDFRT:N0000000954
database_cross_reference: OMIM:125853
database_cross_reference: OMIM:138033
database_cross_reference: OMIM:138160
database_cross_reference: OMIM:138430
database_cross_reference: OMIM:147545
database_cross_reference: OMIM:147670
database_cross_reference: OMIM:164731
database_cross_reference: OMIM:167413
database_cross_reference: OMIM:189907
database_cross_reference: OMIM:600281
database_cross_reference: OMIM:600509
database_cross_reference: OMIM:601724
database_cross_reference: OMIM:604641
database_cross_reference: OMIM:MTHU006778
database_cross_reference: OMIM:MTHU014118
database_cross_reference: OMIM:MTHU023629
database_cross_reference: OMIM:MTHU028982
database_cross_reference: OMIM:MTHU047504
database_cross_reference: OMIM:MTHU051483
database_cross_reference: OMIM:MTHU055395
database_cross_reference: RCD:X40J5
database_cross_reference: SNM:D-2386
database_cross_reference: SNM:D-241Y
database_cross_reference: SNMI:DB-61030
database_cross_reference: SNOMEDCT_US:154672006
database_cross_reference: SNOMEDCT_US:190323008
database_cross_reference: SNOMEDCT_US:190384004

Limitation of neck motion
type: Class
subclass of: Abnormality of the neck
PMOID: PMO:00002483
Subclass_of: Abnormality of the neck
Tree Number: T3.4.2.5

Congenital muscular torticollis
type: Class
subclass of: Abnormality of the musculature of the neck
definition: A congenital form of torticollis resulting from shortening of the sternocleidomastoid muscle and leading to a limited range of motion in both rotation and lateral bending.
PMOID: PMO:00009728
Subclass_of: Abnormality of the musculature of the neck
Synonym: Congen.sternomastoid torticol.
Synonym: Congenital (sternomastoid) torticollis
Synonym: Congenital contracture of sternocleidomastoid
Synonym: Congenital contracture of sternocleidomastoid (muscle)
Synonym: Congenital contracture of sternocleidomastoid muscle
Synonym: Congenital sternomastoid torticollis
Synonym: Congenital sternomastoid torticollis (disorder)
Synonym: Congenital sternomastoid torticollis (disorder) [Ambiguous]
Synonym: Congenital sternomastoid torticollis -RETIRED-
Synonym: Congenital torticollis
Tree Number: T3.17.9.3
database_cross_reference: CHV:0000015158
database_cross_reference: HPO:HP:0005988
database_cross_reference: ICD10CM:Q68.0
database_cross_reference: MDR:10010650
database_cross_reference: MEDCIN:35841
database_cross_reference: MSH:C535425
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:754.1
database_cross_reference: OMIM:MTHU016978
database_cross_reference: RCD:XE1LV
database_cross_reference: SNMI:D4-B2082
database_cross_reference: SNOMEDCT_US:123272007
database_cross_reference: SNOMEDCT_US:156999009
database_cross_reference: SNOMEDCT_US:205041007
database_cross_reference: SNOMEDCT_US:25699004
database_cross_reference: SNOMEDCT_US:268240006
database_cross_reference: SNOMEDCT_US:268345004

Redundant neck skin
type: Class
subclass of: Abnormality of the neck
definition: Excess skin around the neck, often lying in horizontal folds.
PMOID: PMO:00002489
Subclass_of: Abnormality of the neck
Synonym: Excess neck skin
Synonym: Excess skin over the neck
Synonym: Redundant nuchal skin
Synonym: Redundant skin folds of neck
Synonym: Redundant skin over the neck
Tree Number: T3.4.2.7
database_cross_reference: HPO:HP:0005989

Rickets of the lower limbs
type: Class
subclass of: Abnormality of the lower limb
PMOID: PMO:00002829
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.11
database_cross_reference: HPO:HP:0006463

Aplasia/hypoplasia involving bones of the upper limbs
type: Class
subclass of: Abnormality of the upper limb
definition: Absence (due to failure to form) or underdevelopment of the bones of the upper limbs.
PMOID: PMO:00003348
Subclass_of: Abnormality of the upper limb
Synonym: Absent/small bones of the upper limbs
Synonym: Absent/underdeveloped bones of the upper limbs
Tree Number: T3.5.4.9
database_cross_reference: HPO:HP:0006496

Abnormality of lower limb epiphysis morphology
type: Class
subclass of: Abnormality of the lower limb
definition: An anomaly of one or more epiphyses of one or both legs.
PMOID: PMO:00002521
Subclass_of: Abnormality of the lower limb
Synonym: Abnormal shape of end part of lower limb end bone
Synonym: Abnormality involving the epiphyses of the lower limbs
Tree Number: T3.5.2.1
database_cross_reference: HPO:HP:0006500

Abnormal pulmonary lymphatics
type: Class
subclass of: Abnormality of the lymphatic system
definition: An abnormality of the pulmonary lymphatic chain.
PMOID: PMO:00008686
Subclass_of: Abnormality of the lymphatic system
Tree Number: T3.15.3.1
database_cross_reference: HPO:HP:0006529

Obstructive lung disease
type: Class
subclass of: Functional respiratory abnormality
definition: Obstruction of conducting airways of the lung.
PMOID: PMO:00011645
Subclass_of: Functional respiratory abnormality
Synonym: AIRWAY DISEASE OBSTRUCTIVE
Synonym: DISEASE OBSTRUCTIVE LUNG
Synonym: Disease obstructive lung
Synonym: LUNG DIS OBSTRUCTIVE
Synonym: LUNG DISEASE OBSTRUCTIVE
Synonym: Lung Disease, Obstructive
Synonym: Lung Diseases, Obstructive
Synonym: Lung Diseases, Obstructive [Disease/Finding]
Synonym: Lung disease obstructive
Synonym: Lungs--Diseases, Obstructive
Tree Number: T3.19.2.17
database_cross_reference: CCPSS:0045337
database_cross_reference: CCPSS:0046338
database_cross_reference: CHV:0000042221
database_cross_reference: CSP:2596-8463
database_cross_reference: CSP:4004-0004
database_cross_reference: CST:LUNG DIS
database_cross_reference: DO:DOID:2320
database_cross_reference: HPO:HP:0006536
database_cross_reference: LCH_NW:sh85078908
database_cross_reference: MDR:10013108
database_cross_reference: MDR:10025081
database_cross_reference: MDR:10029959
database_cross_reference: MDR:10029973
database_cross_reference: MDR:10061877
database_cross_reference: MSH:D008173
database_cross_reference: NDFRT:N0000001881
database_cross_reference: OMIM:MTHU042826

Sternal punctate calcifications
type: Class
subclass of: Ectopic calcification
PMOID: PMO:00014012
Subclass_of: Ectopic calcification
Tree Number: T3.20.4.8
database_cross_reference: HPO:HP:0006637

Costochondral pain
type: Class
subclass of: Pain
definition: Chest wall pain in the area of the costochondral junctions.
PMOID: PMO:00014089
Subclass_of: Pain
Synonym: Costochondral junction pain
Tree Number: T3.23.10.10
database_cross_reference: HPO:HP:0006649

Retroperitoneal chemodectomas
type: Class
subclass of: Neoplasm by anatomical site
PMOID: PMO:00014264
Subclass_of: Neoplasm by anatomical site
Tree Number: T3.25.1.11
database_cross_reference: HPO:HP:0006729

Malignant genitourinary tract tumor
type: Class
subclass of: Neoplasm of the genitourinary tract
definition: The presence of a malignant neoplasm of the genital system.
PMOID: PMO:00008224
Subclass_of: Neoplasm of the genitourinary tract
Synonym: Malignant genitourinary tract tumors
Tree Number: T3.14.3.3
database_cross_reference: HPO:HP:0006758
database_cross_reference: OMIM:MTHU017052

Multiple myeloma
type: Class
subclass of: Hematological neoplasm
definition: A malignant plasma cell tumor growing within soft tissue or within the skeleton.
PMOID: PMO:00001252
Subclass_of: Hematological neoplasm
Synonym: Cell Myeloma, Plasma
Synonym: Cell Myelomas, Plasma
Synonym: Disease, Kahler
Synonym: KAHLER DISEASE
Synonym: KAHLER-BOZZOLO DISEASE
Synonym: Kahler Disease
Synonym: Kahler disease
Synonym: Kahler's disease
Synonym: MULTIPLE MYELOMA
Synonym: MULTIPLE MYELOMA MYELOMATOSIS
Tree Number: T3.2.10.5
database_cross_reference: AOD:0000004636
database_cross_reference: CCPSS:0046024
database_cross_reference: CHV:0000008325
database_cross_reference: COSTAR:496
database_cross_reference: CSP:2004-0850
database_cross_reference: CST:MYELOMA
database_cross_reference: DO:DOID:9538
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001237
database_cross_reference: HPO:HP:0006775
database_cross_reference: ICD10:C90.0
database_cross_reference: ICD10AM:C90.0
database_cross_reference: ICD10AM:M9732/3
database_cross_reference: ICD10CM:C90.0
database_cross_reference: ICD10CM:C90.00
database_cross_reference: ICD9CM:203.0
database_cross_reference: ICPC2P:B74015
database_cross_reference: LCH:U003053
database_cross_reference: LCH_NW:sh85088367
database_cross_reference: MDR:10028228
database_cross_reference: MDR:10028232
database_cross_reference: MDR:10028566
database_cross_reference: MDR:10028568
database_cross_reference: MDR:10028569
database_cross_reference: MDR:10034613
database_cross_reference: MDR:10035226
database_cross_reference: MDR:10074470
database_cross_reference: MEDCIN:31705
database_cross_reference: MEDLINEPLUS:332
database_cross_reference: MSH:D009101
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:203.0
database_cross_reference: NCI:C3242
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C3242
database_cross_reference: NCI_CTEP-SDC:10028566
database_cross_reference: NCI_NCI-GLOSS:CDR0000045793
database_cross_reference: NCI_NCI-GLOSS:CDR0000045795
database_cross_reference: NCI_NCI-GLOSS:CDR0000411381
database_cross_reference: NCI_NCI-GLOSS:CDR0000411383
database_cross_reference: NCI_NCI-GLOSS:CDR0000411384
database_cross_reference: NDFRT:N0000002050
database_cross_reference: OMIM:254500
database_cross_reference: OMIM:MTHU028344
database_cross_reference: PDQ:CDR0000037974
database_cross_reference: PDQ:CDR0000040068
database_cross_reference: PDQ:CDR0000042947
database_cross_reference: RCD:B630.
database_cross_reference: RCD:BBn0.
database_cross_reference: SNM:M-9730/3
database_cross_reference: SNMI:M-97323
database_cross_reference: SNOMEDCT_US:109989006
database_cross_reference: SNOMEDCT_US:154585004
database_cross_reference: SNOMEDCT_US:55921005
database_cross_reference: SNOMEDCT_US:94705007
database_cross_reference: SNOMEDCT_VET:109989006

Benign genitourinary tract neoplasm
type: Class
subclass of: Neoplasm of the genitourinary tract
definition: A non-malignant neoplasm of the genitourinary system.
PMOID: PMO:00008203
Subclass_of: Neoplasm of the genitourinary tract
Synonym: Benign genitourinary tract tumor
Synonym: Benign genitourinary tract tumors
Tree Number: T3.14.3.1
database_cross_reference: HPO:HP:0006778
database_cross_reference: MDR:10074418
database_cross_reference: OMIM:MTHU017050

Malignant eosinophil proliferation
type: Class
subclass of: Hematological neoplasm
PMOID: PMO:00001251
Subclass_of: Hematological neoplasm
Synonym: EMP
Synonym: EOSINOPHILS, MALIGNANT PROLIFERATION OF
Synonym: Eosinophils, Malignant Proliferation of
Synonym: MPE
Synonym: MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
Synonym: Myeloproliferative Disorder, Chronic, with Eosinophilia
Tree Number: T3.2.10.4
database_cross_reference: HPO:HP:0006782
database_cross_reference: MSH:C565054
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:131440

Impaired thermal sensitivity
type: Class
subclass of: Abnormality of temperature regulation
PMOID: PMO:00004193
Subclass_of: Abnormality of temperature regulation
Tree Number: T3.6.21.4
database_cross_reference: HPO:HP:0006901

Asymmetric limb muscle stiffness
type: Class
subclass of: Abnormality of the musculature of the limbs
definition: Stiffness of the limbs (acondition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in an asymmetric pattern.
PMOID: PMO:00002850
Subclass_of: Abnormality of the musculature of the limbs
Tree Number: T3.5.3.2
database_cross_reference: HPO:HP:0007156

Neoplasm of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
definition: A tumor (abnormal growth of tissue) of the gastrointestinal tract.
PMOID: PMO:00005793
Subclass_of: Abnormality of the gastrointestinal tract
Synonym: Digestive Neoplasm
Synonym: Digestive System Neoplasm
Synonym: Digestive System Tumor
Synonym: Digestive Tumor
Synonym: GASTROINTESTINAL NEOPL
Synonym: GASTROINTESTINAL TUMOR
Synonym: GI NEOPLASIA
Synonym: GI Neoplasm
Synonym: GI System Neoplasm
Synonym: GI System Tumor
Tree Number: T3.10.6.3
database_cross_reference: AOD:0000023051
database_cross_reference: CCPSS:0055048
database_cross_reference: CHV:0000005388
database_cross_reference: CHV:0000031018
database_cross_reference: CSP:2010-0179
database_cross_reference: CST:NEOPL GI
database_cross_reference: DXP:U001651
database_cross_reference: HPO:HP:0007378
database_cross_reference: MDR:10017986
database_cross_reference: MDR:10018238
database_cross_reference: MDR:10028978
database_cross_reference: MDR:10061174
database_cross_reference: MEDCIN:355285
database_cross_reference: MSH:D005770
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3052
database_cross_reference: NDFRT:N0000001321
database_cross_reference: RCD:Xa0DI
database_cross_reference: RCDAE:Xa0DI
database_cross_reference: SNOMEDCT_US:126768004
database_cross_reference: SNOMEDCT_US:276806006

Neoplasm of the genitourinary tract
type: Class
subclass of: Abnormality of the genitourinary system
definition: A tumor (abnormal growth of tissue) of the genitourinary system.
PMOID: PMO:00008202
Subclass_of: Abnormality of the genitourinary system
Synonym: GENITO URINARY NEOPL
Synonym: GENITOURINARY NEOPL
Synonym: Genito-urinary Neoplasm
Synonym: Genito-urinary Neoplasms
Synonym: Genitourinary Neoplasm
Synonym: Genitourinary Neoplasms
Synonym: Genitourinary tract neoplasm
Synonym: Genitourinary tract neoplasm NOS
Synonym: Genitourinary tract tumors
Synonym: NEOPL GENITOURINARY
Tree Number: T3.14.3
database_cross_reference: CHV:0000012802
database_cross_reference: CST:NEOPL UG
database_cross_reference: HPO:HP:0007379
database_cross_reference: MDR:10018192
database_cross_reference: MDR:10029101
database_cross_reference: MDR:10046701
database_cross_reference: MDR:10046702
database_cross_reference: MDR:10046703
database_cross_reference: MDR:10061183
database_cross_reference: MSH:D014565
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000003084

Ipsilateral lack of facial sweating
type: Class
subclass of: Abnormality of skin adnexa physiology
PMOID: PMO:00008953
Subclass_of: Abnormality of skin adnexa physiology
Tree Number: T3.16.2.6
database_cross_reference: HPO:HP:0007451

Generalized anhidrosis
type: Class
subclass of: Abnormality of skin adnexa physiology
PMOID: PMO:00008946
Subclass_of: Abnormality of skin adnexa physiology
Synonym: Generalized inability to sweat
Tree Number: T3.16.2.3
database_cross_reference: HPO:HP:0007459

Autoamputation of digits
type: Class
subclass of: Autoamputation
PMOID: PMO:00003468
Subclass_of: Autoamputation
Tree Number: T3.5.6.1
database_cross_reference: HPO:HP:0007460

Hypohidrosis or hyperhidrosis
type: Class
subclass of: Abnormality of skin adnexa physiology
PMOID: PMO:00008948
Subclass_of: Abnormality of skin adnexa physiology
Synonym: Lack of sweating or excessive sweating
Tree Number: T3.16.2.5
database_cross_reference: HPO:HP:0007550

Abnormal pupillary function
type: Class
subclass of: Abnormal eye physiology
definition: A functional abnormality of the pupil.
PMOID: PMO:00007041
Subclass_of: Abnormal eye physiology
Synonym: Disorder of pupil
Synonym: PUPIL DIS
Synonym: PUPILLARY DIS
Synonym: PUPILLARY DISORDER
Synonym: Pupil Disorder
Synonym: Pupil Disorders
Synonym: Pupil Disorders [Disease/Finding]
Synonym: Pupil disorders
Synonym: Pupillary Disorder
Synonym: Pupillary Disorders
Tree Number: T3.13.2.3
database_cross_reference: CST:PUPIL DIS
database_cross_reference: DO:DOID:238
database_cross_reference: HPO:HP:0007686
database_cross_reference: MDR:10037514
database_cross_reference: MDR:10037521
database_cross_reference: MDR:10037522
database_cross_reference: MSH:D011681
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002551
database_cross_reference: SNMI:DA-72710
database_cross_reference: SNOMEDCT_US:68633000

Chorioretinal scar
type: Class
subclass of: Scarring
definition: Fibrous connective tissue resulting from incomplete healing of a wound (i.e., a scar) located in the choroid and retina or the eye.
PMOID: PMO:00001364
Subclass_of: Scarring
Synonym: Chorioretinal scar (disorder)
Synonym: Chorioretinal scar NOS
Synonym: Chorioretinal scar, NOS
Synonym: Chorioretinal scar, unspecified
Synonym: Chorioretinal scars
Synonym: Chorioretinal scars NOS
Synonym: Chorioretinal scars NOS (disorder)
Synonym: Unspecified chorioretinal scar
Synonym: Unspecified chorioretinal scar (disorder)
Synonym: Unspecified chorioretinal scars
Tree Number: T3.3.10.1
database_cross_reference: DO:DOID:11086
database_cross_reference: HPO:HP:0007777
database_cross_reference: ICD10:H31.0
database_cross_reference: ICD10AM:H31.0
database_cross_reference: ICD10CM:H31.0
database_cross_reference: ICD10CM:H31.00
database_cross_reference: ICD9CM:363.3
database_cross_reference: ICD9CM:363.30
database_cross_reference: MDR:10008766
database_cross_reference: MDR:10008767
database_cross_reference: MDR:10008768
database_cross_reference: MEDCIN:11480
database_cross_reference: MEDCIN:334861
database_cross_reference: RCD:F433.
database_cross_reference: RCD:F4330
database_cross_reference: RCD:F433z
database_cross_reference: SNM:M-49060
database_cross_reference: SNMI:DA-71200
database_cross_reference: SNOMEDCT_US:193455005
database_cross_reference: SNOMEDCT_US:193460009
database_cross_reference: SNOMEDCT_US:53854005

Abnormality of the vasculature of the eye
type: Class
subclass of: Abnormal eye morphology
PMOID: PMO:00006965
Subclass_of: Abnormal eye morphology
Synonym: Abnormality of eye blood vessels
Tree Number: T3.13.1.7
database_cross_reference: HPO:HP:0008047

Aplasia/Hypoplasia affecting the eye
type: Class
subclass of: Abnormal eye morphology
PMOID: PMO:00006974
Subclass_of: Abnormal eye morphology
Synonym: Absent/small eye
Synonym: Absent/underdeveloped eye
Tree Number: T3.13.1.8
database_cross_reference: HPO:HP:0008056

Neoplasm of the skin
type: Class
subclass of: Abnormality of the skin
definition: A tumor (abnormal growth of tissue) of the skin.
PMOID: PMO:00009419
Subclass_of: Abnormality of the skin
Synonym: Cutaneous neoplasm
Synonym: Cutaneous tumor
Synonym: Cutaneous tumour
Synonym: Dermatological tumors
Synonym: NEOPL SKIN
Synonym: NEOPLASM SKIN
Synonym: Neoplasia of the skin
Synonym: Neoplasm of Skin
Synonym: Neoplasm of skin
Synonym: Neoplasm of skin (disorder)
Tree Number: T3.16.3.3
database_cross_reference: AOD:0000023027
database_cross_reference: CCPSS:1009015
database_cross_reference: CHV:0000011397
database_cross_reference: CSP:2020-0536
database_cross_reference: CST:NEOPL SKIN
database_cross_reference: CST:SKINTUMOR
database_cross_reference: DO:DOID:3165
database_cross_reference: DXP:U003701
database_cross_reference: HPO:HP:0008069
database_cross_reference: ICPC2P:S79013
database_cross_reference: LCH_NW:sh85123187
database_cross_reference: MDR:10029098
database_cross_reference: MDR:10040897
database_cross_reference: MDR:10040940
database_cross_reference: MDR:10040941
database_cross_reference: MDR:10058215
database_cross_reference: MEDCIN:39014
database_cross_reference: MSH:D012878
database_cross_reference: MTH:102
database_cross_reference: MTH:684
database_cross_reference: MTH:685
database_cross_reference: MTH:686
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3372
database_cross_reference: NDFRT:N0000002768
database_cross_reference: PDQ:CDR0000038969
database_cross_reference: RCD:X78RN
database_cross_reference: RCDAE:X78RN
database_cross_reference: SNOMEDCT_US:126488004
database_cross_reference: SNOMEDCT_US:363230005
database_cross_reference: SNOMEDCT_VET:126488004

Maternal virilization in pregnancy
type: Class
subclass of: Prenatal maternal abnormality
definition: Virilization (deepening of voice, facial hirsutism and scalp hair loss) with onset during pregnancy (usually towards the end of the first trimester) and regression several months post-partum.
PMOID: PMO:00004402
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.10
database_cross_reference: HPO:HP:0008072

Tarsal stippling
type: Class
subclass of: Ectopic calcification
definition: The presence of abnormal punctate (speckled, dot-like) calcifications in one or more tarsal bones.
PMOID: PMO:00014013
Subclass_of: Ectopic calcification
Synonym: Punctate calcifications of tarsals
Synonym: Punctate tarsal calcification
Tree Number: T3.20.4.9
database_cross_reference: HPO:HP:0008131

Hyperapobetalipoproteinemia
type: Class
subclass of: Abnormality of lipid metabolism
definition: Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein.
PMOID: PMO:00004131
Subclass_of: Abnormality of lipid metabolism
Synonym: COMBINED HYPERLIPIDEMIA, FAMILIAL
Synonym: Combined Hyperlipidemia, Familial
Synonym: Combined Hyperlipidemias, Familial
Synonym: FAMILIAL COMBINED HYPERLIPIDEMIA
Synonym: FCHL
Synonym: FCHL (familial combined hyperlipidemia)
Synonym: FCHL - Familial combined hyperlipidaemia
Synonym: FCHL - Familial combined hyperlipidemia
Synonym: FCHL -Famil comb hyperlipidaem
Synonym: Fam hyperlipoproteinaemia IIb
Tree Number: T3.6.17.5
database_cross_reference: CHV:0000006420
database_cross_reference: DO:DOID:13809
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0008158
database_cross_reference: ICD10CM:E78.4
database_cross_reference: MDR:10045263
database_cross_reference: MDR:10054675
database_cross_reference: MEDCIN:33852
database_cross_reference: MEDLINEPLUS:26
database_cross_reference: MEDLINEPLUS:4277
database_cross_reference: MSH:D006950
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C35637
database_cross_reference: NDFRT:N0000001593
database_cross_reference: OMIM:144250
database_cross_reference: OMIM:609708
database_cross_reference: RCD:X40Vm
database_cross_reference: RCDAE:X40Vm
database_cross_reference: SNMI:D6-60450
database_cross_reference: SNOMEDCT_US:154742006
database_cross_reference: SNOMEDCT_US:190780005
database_cross_reference: SNOMEDCT_US:238040008
database_cross_reference: SNOMEDCT_US:299465007
database_cross_reference: SNOMEDCT_US:48190005

Neonatal unconjugated hyperbilirubinemia
type: Class
subclass of: Hyperbilirubinemia
PMOID: PMO:00004260
Subclass_of: Hyperbilirubinemia
Synonym: Neonat unconj hyperbilirubin
Synonym: Neonatal unconjugated hyperbilirubinaemia
Synonym: Neonatal unconjugated hyperbilirubinemia (disorder)
Tree Number: T3.6.29.4
database_cross_reference: HPO:HP:0008176
database_cross_reference: RCD:Xa1op
database_cross_reference: RCDAE:Xa1op
database_cross_reference: SNOMEDCT_US:281611002

Absence of secondary sex characteristics
type: Class
subclass of: Puberty and gonadal disorders
definition: No secondary sexual characteristics are present at puberty.
PMOID: PMO:00006399
Subclass_of: Puberty and gonadal disorders
Synonym: No secondary sexual characteristics at puberty
Tree Number: T3.12.15.3
database_cross_reference: HPO:HP:0008187

Primary gonadal insufficiency
type: Class
subclass of: Puberty and gonadal disorders
PMOID: PMO:00006418
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.10
database_cross_reference: HPO:HP:0008193

Absence of pubertal development
type: Class
subclass of: Puberty and gonadal disorders
PMOID: PMO:00006397
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.2
database_cross_reference: HPO:HP:0008197

Androgen insufficiency
type: Class
subclass of: Puberty and gonadal disorders
definition: Insufficient amount of androgenic activity.
PMOID: PMO:00006401
Subclass_of: Puberty and gonadal disorders
Synonym: ANDROGEN DEFICIENCY
Synonym: Androgen deficiency
Synonym: Androgen deficiency, NOS
Synonym: Defect of testicular androgen synthesis
Synonym: Defect testicul androgen synth
Synonym: Defective biosynthesis of testicular androgen
Synonym: Defective biosynthesis of testicular androgen NOS
Synonym: Defective biosynthesis of testicular androgen, NOS
Synonym: Deficiency of testosterone biosynthesis
Synonym: Deficiency of testosterone biosynthesis (disorder)
Tree Number: T3.12.15.5
database_cross_reference: CHV:0000030771
database_cross_reference: CST:ENDO DIS
database_cross_reference: HPO:HP:0008226
database_cross_reference: ICD10CM:E29.1
database_cross_reference: MDR:10002261
database_cross_reference: MDR:10066867
database_cross_reference: MTHICD9:257.2
database_cross_reference: NCI:C102987
database_cross_reference: NCI_NICHD:C102987
database_cross_reference: RCD:X40Nl
database_cross_reference: SNMI:DB-30700
database_cross_reference: SNOMEDCT_US:38825009
database_cross_reference: SNOMEDCT_VET:282211000009103

Unconjugated hyperbilirubinemia
type: Class
subclass of: Hyperbilirubinemia
definition: An increased amount of unconjugated (indirect) bilurubin in the blood.
PMOID: PMO:00004261
Subclass_of: Hyperbilirubinemia
Synonym: Hyperbilirubinemia, unconjugated
Synonym: Indirect Hyperbilirubinemia
Synonym: Indirect hyperbilirubinaemia
Synonym: Indirect hyperbilirubinemia
Synonym: Unconjd hyperbilirubinaemia
Synonym: Unconjd hyperbilirubinemia
Synonym: Unconjugated Hyperbilirubinemia
Synonym: Unconjugated hyperbilirubinaemia
Synonym: Unconjugated hyperbilirubinemia (disorder)
Synonym: Unconjugated hyperbilirubinemia, NOS
Tree Number: T3.6.29.5
database_cross_reference: CHV:0000026290
database_cross_reference: HPO:HP:0008282
database_cross_reference: MDR:10075817
database_cross_reference: MDR:10075822
database_cross_reference: MEDCIN:362611
database_cross_reference: NCI:C113785
database_cross_reference: NCI_NICHD:C113785
database_cross_reference: OMIM:MTHU037532
database_cross_reference: RCD:X307f
database_cross_reference: RCDAE:X307f
database_cross_reference: SNMI:D6-84100
database_cross_reference: SNOMEDCT_US:7752002

Abnormality of vitamin A metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
PMOID: PMO:00004202
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.1
database_cross_reference: HPO:HP:0008372

Puberty and gonadal disorders
type: Class
subclass of: Abnormality of the endocrine system
PMOID: PMO:00006395
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.15
database_cross_reference: HPO:HP:0008373

Aplasia/Hypoplasia of the ear
type: Class
subclass of: Abnormal ear morphology
definition: The presence of aplasia or developmental hypoplasia of the ear.
PMOID: PMO:00006057
Subclass_of: Abnormal ear morphology
Synonym: Absent/small ear
Synonym: Absent/underdeveloped ear
Tree Number: T3.11.1.4
database_cross_reference: HPO:HP:0008771

Postnatal growth retardation
type: Class
subclass of: Growth delay
definition: Slow or limited growth after birth.
PMOID: PMO:00014178
Subclass_of: Growth delay
Synonym: Growth delay as children
Synonym: Growth retardation as children
Synonym: Postnatal growth deceleration
Synonym: Postnatal growth deficiency
Synonym: Postnatal growth failure
Tree Number: T3.24.4.3
database_cross_reference: HPO:HP:0008897

Increased intramuscular fat
type: Class
subclass of: Abnormality of the musculature
definition: An abnormal increase in the amount of intramuscular fat tissue.
PMOID: PMO:00009750
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.14
database_cross_reference: HPO:HP:0008985

Hypoplasia of serratus anterior muscle
type: Class
subclass of: Abnormality of the musculature of the thorax
definition: Underdevelopment of the serratus anterior muscle, which is involved in abduction, upward Rotation, and elevation of the scapula.
PMOID: PMO:00009747
Subclass_of: Abnormality of the musculature of the thorax
Tree Number: T3.17.11.3
database_cross_reference: HPO:HP:0009011

Increased connective tissue
type: Class
subclass of: Abnormality of connective tissue
definition: The presence of an abnormally increased amount of connective tissue.
PMOID: PMO:00001361
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.8
database_cross_reference: HPO:HP:0009025

Hypoplasia of latissimus dorsi muscle
type: Class
subclass of: Abnormality of the musculature of the thorax
definition: Underdevelopment of the latissimus dorsi muscle, which is involved in adduction, extension, internal rotation, and transverse extension of the shoulder and assists in movement of the scapula.
PMOID: PMO:00009746
Subclass_of: Abnormality of the musculature of the thorax
Tree Number: T3.17.11.2
database_cross_reference: HPO:HP:0009026

Generalized weakness of limb muscles
type: Class
subclass of: Abnormality of the musculature of the limbs
definition: Generalized weakness of the muscles of the arms and legs.
PMOID: PMO:00002851
Subclass_of: Abnormality of the musculature of the limbs
Tree Number: T3.5.3.3
database_cross_reference: HPO:HP:0009028

Speech articulation difficulties
type: Class
subclass of: Abnormality of the voice
definition: Impairment in the physical production of speech sounds.
PMOID: PMO:00014037
Subclass_of: Abnormality of the voice
Tree Number: T3.22.10
database_cross_reference: HPO:HP:0009088

Denervation of the diaphragm
type: Class
subclass of: Abnormality of the diaphragm
definition: Interruption of the innervation of the diaphragm.
PMOID: PMO:00009721
Subclass_of: Abnormality of the diaphragm
Tree Number: T3.17.8.3
database_cross_reference: HPO:HP:0009109

Diaphragmatic eventration
type: Class
subclass of: Abnormality of the diaphragm
definition: A congenital failure of muscular development of part or all of one or both hemidiaphragms, resulting in superior displacement of abdominal viscera and altered lung development.
PMOID: PMO:00009722
Subclass_of: Abnormality of the diaphragm
Synonym: DIAPHRAGM, EVENTRATION
Synonym: DIAPHRAGMATIC EVENTRATION
Synonym: Diaphragm Eventration
Synonym: Diaphragm eventration
Synonym: Diaphragmatic Eventration
Synonym: Diaphragmatic Eventration [Disease/Finding]
Synonym: Diaphragmatic eventration (disorder)
Synonym: Eventration of Diaphragm
Synonym: Eventration of diaphragm
Synonym: Eventration of the diaphragm
Tree Number: T3.17.8.4
database_cross_reference: CHV:0000003864
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10480
database_cross_reference: DXP:U000477
database_cross_reference: HPO:HP:0009110
database_cross_reference: ICD10CM:Q79.1
database_cross_reference: MEDCIN:33006
database_cross_reference: MSH:D003965
database_cross_reference: MTHICD9:756.6
database_cross_reference: NCI:C98912
database_cross_reference: NCI_CDISC:C98912
database_cross_reference: NCI_NICHD:C98912
database_cross_reference: NDFRT:N0000000961
database_cross_reference: OMIM:MTHU037386
database_cross_reference: OMIM:MTHU037914
database_cross_reference: OMIM:MTHU038310
database_cross_reference: SNM:M-31410
database_cross_reference: SNMI:D2-82060
database_cross_reference: SNOMEDCT_US:157006001
database_cross_reference: SNOMEDCT_US:268351009
database_cross_reference: SNOMEDCT_US:34168003

Diaphragmatic weakness
type: Class
subclass of: Abnormality of the diaphragm
definition: A decrease in the strength of the diaphragm.
PMOID: PMO:00009723
Subclass_of: Abnormality of the diaphragm
Synonym: Diaphragmatic paraparesis
Synonym: Weak diaphragm
Tree Number: T3.17.8.5
database_cross_reference: HPO:HP:0009113

Aplasia/hypoplasia involving the skeleton
type: Class
subclass of: Abnormality of skeletal morphology
definition: Absence (due to failure to form) or underdevelopment of one or more components of the skeleton.
PMOID: PMO:00013952
Subclass_of: Abnormality of skeletal morphology
Synonym: Absent/small skeleton
Synonym: Absent/underdeveloped skeleton
Tree Number: T3.20.1.10
database_cross_reference: HPO:HP:0009115

Abnormal axial skeleton morphology
type: Class
subclass of: Abnormality of skeletal morphology
definition: An abnormality of the axial skeleton, which comprises the skull, the vertebral column, the ribs and the sternum.
PMOID: PMO:00013265
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.2
database_cross_reference: HPO:HP:0009121

Abnormal adipose tissue morphology
type: Class
subclass of: Abnormality of connective tissue
definition: An abnormality of adipose tissue, which is loose connective tissue composed of adipocytes.
PMOID: PMO:00001260
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.1

Lipodystrophy
type: Class
subclass of: Abnormal adipose tissue morphology
definition: Degenerative changes of the fat tissue.
PMOID: PMO:00001290
Subclass_of: Abnormal adipose tissue morphology
Synonym: CUTANEOUS LIPODYSTROPHY
Synonym: Dystrophy of fatty tissue
Synonym: Dystrophy, fatty tissue
Synonym: LIPODYSTROPHY
Synonym: Lipodystrophies
Synonym: Lipodystrophy (disorder)
Synonym: Lipodystrophy NOS
Synonym: Lipodystrophy NOS (disorder)
Synonym: Lipodystrophy [Disease/Finding]
Synonym: Lipodystrophy, NOS
Tree Number: T3.3.1.7
database_cross_reference: AOD:0000005730
database_cross_reference: CHV:0000007457
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000169
database_cross_reference: CSP:1745-6360
database_cross_reference: CST:LIPODYSTROPHY
database_cross_reference: DO:DOID:811
database_cross_reference: HPO:HP:0009125
database_cross_reference: ICD10CM:E88.1
database_cross_reference: ICD9CM:272.6
database_cross_reference: ICPC2P:T93017
database_cross_reference: ICPC2P:T99075
database_cross_reference: MDR:10024606
database_cross_reference: MDR:10024608
database_cross_reference: MEDCIN:338592
database_cross_reference: MSH:D008060
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C97093
database_cross_reference: NDFRT:N0000001850
database_cross_reference: OMIM:MTHU037286
database_cross_reference: RCD:C326z
database_cross_reference: RCD:XE11X
database_cross_reference: SNM:M-56020
database_cross_reference: SNMI:DB-61700
database_cross_reference: SNOMEDCT_US:190789006
database_cross_reference: SNOMEDCT_US:190790002
database_cross_reference: SNOMEDCT_US:71325002

Increased adipose tissue
type: Class
subclass of: Abnormal adipose tissue morphology
definition: An increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell).
PMOID: PMO:00001287
Subclass_of: Abnormal adipose tissue morphology
Synonym: Increased fat tissue
Tree Number: T3.3.1.6
database_cross_reference: HPO:HP:0009126

Abnormality of the musculature of the limbs
type: Class
subclass of: Abnormality of limbs
PMOID: PMO:00002831
Subclass_of: Abnormality of limbs
Synonym: Abnormal limb muscles
Tree Number: T3.5.3
database_cross_reference: HPO:HP:0009127

Abnormality of the musculature of the thorax
type: Class
subclass of: Abnormality of the musculature
definition: A disease or lesion affecting the muscles of the thorax.
PMOID: PMO:00009739
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.11
database_cross_reference: HPO:HP:0009131

Depletion of mitochondrial DNA in muscle tissue
type: Class
subclass of: Muscle abnormality related to mitochondrial dysfunction
PMOID: PMO:00009753
Subclass_of: Muscle abnormality related to mitochondrial dysfunction
Synonym: Depletion of mitochondrial dna in skeletal muscle tissue
Tree Number: T3.17.15.2
database_cross_reference: HPO:HP:0009141

Duplication of bones involving the upper extremities
type: Class
subclass of: Abnormality of the upper limb
PMOID: PMO:00003397
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.10
database_cross_reference: HPO:HP:0009142

Neoplasm of striated muscle
type: Class
subclass of: Neoplasm by anatomical site
definition: A benign or malignant neoplasm (tumour) originating in striated muscle, either skeletal muscle or cardiac muscle.
PMOID: PMO:00014202
Subclass_of: Neoplasm by anatomical site
Synonym: Tumors of striated muscle
Tree Number: T3.25.1.3
database_cross_reference: HPO:HP:0009728

Limb pain
type: Class
subclass of: Pain
definition: Chronic pain in the limbs with no clear focal etiology.
PMOID: PMO:00014100
Subclass_of: Pain
Synonym: Aching in limb
Synonym: EXTREMITY PAIN
Synonym: LIMB PAIN
Synonym: Limb pain NOS
Synonym: Limb pain, NOS
Synonym: Pain in Extremity
Synonym: Pain in extremities
Synonym: Pain in extremity
Synonym: Pain in limb
Synonym: Pain in limb &/or NOS
Tree Number: T3.23.10.21
database_cross_reference: CCPSS:1015738
database_cross_reference: CHV:0000009186
database_cross_reference: COSTAR:453
database_cross_reference: DXP:U001261
database_cross_reference: HPO:HP:0009763
database_cross_reference: ICD10:M79.6
database_cross_reference: ICD10AM:M79.6
database_cross_reference: ICD10AM:M79.69
database_cross_reference: ICD10CM:M79.609
database_cross_reference: ICD9CM:729.5
database_cross_reference: ICPC2P:L29007
database_cross_reference: MDR:10000448
database_cross_reference: MDR:10033425
database_cross_reference: MDR:10033447
database_cross_reference: MDR:10033471
database_cross_reference: MDR:10033472
database_cross_reference: MEDCIN:116644
database_cross_reference: MEDCIN:335409
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78515
database_cross_reference: NCI_CTCAE:E12512
database_cross_reference: RCD:XE1Fp
database_cross_reference: RCD:Xa3h2
database_cross_reference: SNMI:D1-50740
database_cross_reference: SNOMEDCT_US:156761008
database_cross_reference: SNOMEDCT_US:156767007
database_cross_reference: SNOMEDCT_US:203124006
database_cross_reference: SNOMEDCT_US:268112008
database_cross_reference: SNOMEDCT_US:287049006
database_cross_reference: SNOMEDCT_US:90834002

Branchial anomaly
type: Class
subclass of: Abnormality of the neck
definition: Congenital developmental defect arising from the primitive branchial apparatus.
PMOID: PMO:00002474
Subclass_of: Abnormality of the neck
Synonym: Abnormality of branchial apparatus
Synonym: Abnormality of branchial arch
Synonym: Branchial abnormality
Synonym: Branchial anomalies
Tree Number: T3.4.2.1
database_cross_reference: HPO:HP:0009794
database_cross_reference: OMIM:MTHU019218

Maternal diabetes
type: Class
subclass of: Prenatal maternal abnormality
definition: Maternal diabetes can either be a gestational, mostly type 2 diabetes, or a type 1 diabetes. Essential is the resulting maternal hyperglycemia as a non-specific teratogen, imposing the same risk of congenital malformations to pregnant women with both type 1 and type2 diabetes.
PMOID: PMO:00004395
Subclass_of: Prenatal maternal abnormality
Synonym: -- Gestational Diabetes
Synonym: DIABETES MELLITUS (GESTATIONAL)
Synonym: DIABETES MELLITUS GESTATIONAL
Synonym: DIABETES PREGN IND
Synonym: Diabetes Mellitus, Gestational
Synonym: Diabetes and Pregnancy
Synonym: Diabetes gestatational
Synonym: Diabetes in Pregnancy
Synonym: Diabetes mel aris in pregnancy
Synonym: Diabetes mellitus arising in pregnancy
Tree Number: T3.7.11.5
database_cross_reference: BI:BI00337
database_cross_reference: CCPSS:0037256
database_cross_reference: CHV:0000015496
database_cross_reference: CHV:0000049938
database_cross_reference: COSTAR:U000227
database_cross_reference: COSTAR:U000400
database_cross_reference: CSP:0862-6650
database_cross_reference: DO:DOID:11714
database_cross_reference: HPO:HP:0009800
database_cross_reference: ICD10:O24.4
database_cross_reference: ICD10AM:O24.4
database_cross_reference: ICD10CM:O24.4
database_cross_reference: ICPC2EENG:W85
database_cross_reference: ICPC2P:W77004
database_cross_reference: ICPC2P:W85001
database_cross_reference: LNC:LA10553-8
database_cross_reference: LNC:LA19979-6
database_cross_reference: MDR:10012606
database_cross_reference: MDR:10018209
database_cross_reference: MDR:10018210
database_cross_reference: MEDCIN:33909
database_cross_reference: MEDLINEPLUS:1408
database_cross_reference: MSH:D016640
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34942
database_cross_reference: NCI_NICHD:C34942
database_cross_reference: NDFRT:N0000003450
database_cross_reference: OMIM:MTHU004757
database_cross_reference: RCD:L1808
database_cross_reference: SNM:D-2403
database_cross_reference: SNM:D-2410
database_cross_reference: SNMI:DB-61400
database_cross_reference: SNOMEDCT_US:11687002
database_cross_reference: SNOMEDCT_US:199232003
database_cross_reference: SNOMEDCT_US:237629002
database_cross_reference: SNOMEDCT_US:359964007
database_cross_reference: SNOMEDCT_US:393568003

Nephrogenic diabetes insipidus
type: Class
subclass of: Diabetes insipidus
definition: A form of diabetes insipidus caused by failure of the kidneys to respond to vasopressin (AVP).
PMOID: PMO:00006361
Subclass_of: Diabetes insipidus
Synonym: DIABETES INSIPIDUS NEPHROGENIC
Synonym: DIABETES INSIPIDUS, NEPHROGENIC
Synonym: Diabetes Insipidus, Nephrogenic
Synonym: Diabetes Insipidus, Nephrogenic [Disease/Finding]
Synonym: Diabetes insipidus nephrogenic
Synonym: NDI - Nephrogen diab insipidus
Synonym: NDI - Nephrogenic diabetes insipidus
Synonym: Nephrogen diabetes insip
Synonym: Nephrogenic Diabetes Insipidus
Synonym: Nephrogenic diabetes insipidus (disorder)
Tree Number: T3.12.12.2
database_cross_reference: CCPSS:0014348
database_cross_reference: CHV:0000017777
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1849-2659
database_cross_reference: CST:DIABETES INSIPID
database_cross_reference: DO:DOID:12387
database_cross_reference: DXP:U000468
database_cross_reference: HPO:HP:0009806
database_cross_reference: ICD10:N25.1
database_cross_reference: ICD10AM:N25.1
database_cross_reference: ICD10CM:N25.1
database_cross_reference: ICD9CM:588.1
database_cross_reference: MDR:10012600
database_cross_reference: MDR:10029147
database_cross_reference: MEDCIN:30493
database_cross_reference: MSH:D018500
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84919
database_cross_reference: NCI_NICHD:C84919
database_cross_reference: NDFRT:N0000003831
database_cross_reference: RCD:K081.
database_cross_reference: SNMI:D6-98326
database_cross_reference: SNOMEDCT_US:111395007
database_cross_reference: SNOMEDCT_US:123294004

Anomaly of the upper limb diaphyses
type: Class
subclass of: Abnormality of the upper limb
definition: A structural abnormality of a diaphysis of the arm.
PMOID: PMO:00003342
Subclass_of: Abnormality of the upper limb
Synonym: Abnormality involving the diaphyses of the upper limbs
Synonym: Abnormality of shaft of long bone of the upper limbs
Synonym: Diaphyseal abnormality of the upper limbs
Tree Number: T3.5.4.8
database_cross_reference: HPO:HP:0009808

Abnormality of upper limb joint
type: Class
subclass of: Abnormality of the upper limb
PMOID: PMO:00003246
Subclass_of: Abnormality of the upper limb
Synonym: Abnormality of the joints of the upper limbs
Tree Number: T3.5.4.6
database_cross_reference: HPO:HP:0009810

Aplasia/hypoplasia of the extremities
type: Class
subclass of: Abnormality of limbs
definition: Absence (due to failure to form) or underdevelopment of the extremities.
PMOID: PMO:00003448
Subclass_of: Abnormality of limbs
Synonym: Absent/small extremities
Synonym: Absent/underdeveloped extremities
Synonym: Short or absent limbs
Synonym: Shortened limbs
Tree Number: T3.5.5
database_cross_reference: HPO:HP:0009815

Limb undergrowth
type: Class
subclass of: Aplasia/hypoplasia of the extremities
definition: Limb shortening because of underdevelopment of one or more bones of the extremities.
PMOID: PMO:00003454
Subclass_of: Aplasia/hypoplasia of the extremities
Synonym: Hypoplasia involving bones of the extremities
Synonym: Short limb
Synonym: Short limbs
Synonym: limb shortening
Tree Number: T3.5.5.3
database_cross_reference: HPO:HP:0009826

Amelia
type: Class
subclass of: Aplasia/hypoplasia of the extremities
definition: Congenital absence (aplasia) of one or more limbs.
PMOID: PMO:00003451
Subclass_of: Aplasia/hypoplasia of the extremities
Synonym: AMELIA
Synonym: Amelia (disorder)
Synonym: Amelia NOS
Synonym: Amelia of unspecified limb
Synonym: Amelia of unspecified limb (disorder)
Synonym: Amelia, NOS
Synonym: Congenital absence of limb
Synonym: Congenital absence of limb NOS
Synonym: Congenital absence of limb NOS (disorder)
Synonym: Congenital absence of limb, NOS
Tree Number: T3.5.5.2
database_cross_reference: CHV:0000000985
database_cross_reference: CST:ECTROMELIA
database_cross_reference: HPO:HP:0009827
database_cross_reference: ICD10:Q73.0
database_cross_reference: ICD10AM:Q73.0
database_cross_reference: ICD10CM:Q73.0
database_cross_reference: MDR:10001926
database_cross_reference: MSH:D004480
database_cross_reference: MTHICD9:755.4
database_cross_reference: NCI:C34370
database_cross_reference: NCI_NICHD:C34370
database_cross_reference: RCD:PF40.
database_cross_reference: RCD:PF41.
database_cross_reference: SNM:M-21010
database_cross_reference: SNMI:D4-12102
database_cross_reference: SNOMEDCT_US:205236007
database_cross_reference: SNOMEDCT_US:205238008
database_cross_reference: SNOMEDCT_US:62588002

Peromelia
type: Class
subclass of: Aplasia/hypoplasia of the extremities
definition: The distal parts of the limbs are missing leading to a stump formation.
PMOID: PMO:00003466
Subclass_of: Aplasia/hypoplasia of the extremities
Tree Number: T3.5.5.4
database_cross_reference: HPO:HP:0009828

Abnormally low-pitched voice
type: Class
subclass of: Abnormality of the voice
definition: An abnormally low-pitched voice.
PMOID: PMO:00014028
Subclass_of: Abnormality of the voice
Tree Number: T3.22.3
database_cross_reference: HPO:HP:0010300

Aplasia/Hypoplasia of the breasts
type: Class
subclass of: Abnormal breast morphology
definition: Absence or underdevelopment of the breasts.
PMOID: PMO:00004429
Subclass_of: Abnormal breast morphology
Synonym: Absent/small breasts
Synonym: Absent/underdeveloped breasts
Tree Number: T3.8.1.2
database_cross_reference: HPO:HP:0010311

Asymmetry of the breasts
type: Class
subclass of: Abnormal breast morphology
definition: The presence of asymmetrical breasts.
PMOID: PMO:00004434
Subclass_of: Abnormal breast morphology
Synonym: ANISOMASTIA
Synonym: Anisomastia
Synonym: Breast asymmetry
Tree Number: T3.8.1.3
database_cross_reference: HPO:HP:0010312
database_cross_reference: MDR:10068732
database_cross_reference: MDR:10076298
database_cross_reference: MSH:C565299
database_cross_reference: OMIM:605746

Breast hypertrophy
type: Class
subclass of: Abnormal breast morphology
definition: The presence of hypertrophy of the breast.
PMOID: PMO:00004435
Subclass_of: Abnormal breast morphology
Synonym: Breast Hypertrophy
Synonym: Hypertrophy - breast
Synonym: Hypertrophy breast
Synonym: Hypertrophy of Breast
Synonym: Hypertrophy of breast
Synonym: Hypertrophy of breast (disorder)
Synonym: Hypertrophy of breast NOS
Synonym: Hypertrophy of breast NOS (disorder)
Synonym: Hypertrophy of breast, NOS
Synonym: Hypertrophy of the Breast
Tree Number: T3.8.1.4
database_cross_reference: CHV:0000006457
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10688
database_cross_reference: HPO:HP:0010313
database_cross_reference: ICD10:N62
database_cross_reference: ICD10AM:N62
database_cross_reference: ICD10CM:N62
database_cross_reference: ICD9CM:611.1
database_cross_reference: MDR:10020881
database_cross_reference: MDR:10020885
database_cross_reference: MDR:10026733
database_cross_reference: MEDCIN:7100
database_cross_reference: MEDCIN:91891
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:611.1
database_cross_reference: NCI:C3125
database_cross_reference: RCD:K311.
database_cross_reference: RCD:K311z
database_cross_reference: SNMI:D7-90400
database_cross_reference: SNOMEDCT_US:155963008
database_cross_reference: SNOMEDCT_US:198114003
database_cross_reference: SNOMEDCT_US:266646002
database_cross_reference: SNOMEDCT_US:372281005
database_cross_reference: SNOMEDCT_US:43336006

Aplasia/Hypoplasia of the diaphragm
type: Class
subclass of: Abnormality of the diaphragm
definition: Absence or underdevelopment of the diaphragm.
PMOID: PMO:00009718
Subclass_of: Abnormality of the diaphragm
Synonym: Absent/small diaprhagm
Synonym: Absent/underdeveloped diaprhagm
Tree Number: T3.17.8.2
database_cross_reference: HPO:HP:0010315

Oligosacchariduria
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: Increased urinary excretion of oligosaccharides (low molecular weight carbohydrate chains composed of at least three monosaccharide subunits), derived from a partial degradation of glycoproteins.
PMOID: PMO:00003760
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.32
database_cross_reference: HPO:HP:0010471

Abnormality of the heme biosynthetic pathway
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality in the synthesis or catabolism of heme. Heme is composed of ferrous iron and protoporphyrin IX and is an essential molecule as the prosthetic group of hemeproteins such as hemoglobin, myoglobin, mitochondrial and microsomal cytochromes.
PMOID: PMO:00004196
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.22
database_cross_reference: HPO:HP:0010472

Porphyrinuria
type: Class
subclass of: Abnormality of the heme biosynthetic pathway
definition: Abnormally increased excretion of porphyrins in the urine.
PMOID: PMO:00004200
Subclass_of: Abnormality of the heme biosynthetic pathway
Synonym: PORPHYRINURIA
Synonym: Porphyrins urinary excretion incr
Synonym: Porphyrins urinary excretion increased
Synonym: Porphyruria
Synonym: Porphyruria (disorder)
Synonym: porphyrinuria
Synonym: porphyrinuria (diagnosis)
Synonym: porphyruria
Tree Number: T3.6.22.4
database_cross_reference: CHV:0000017090
database_cross_reference: CST:PORPHYRINURIA
database_cross_reference: HPO:HP:0010473
database_cross_reference: MDR:10036191
database_cross_reference: MDR:10036192
database_cross_reference: MDR:10036193
database_cross_reference: MEDCIN:273595
database_cross_reference: MTHICD9:277.1
database_cross_reference: SNMI:D6-88420
database_cross_reference: SNOMEDCT_US:44574006

Urethral fistula
type: Class
subclass of: Urogenital fistula
definition: The presence of an abnormal connection between the urethra and another organ or the skin.
PMOID: PMO:00008247
Subclass_of: Urogenital fistula
Synonym: URETHRA FISTULA
Synonym: URETHRAL FISTULA
Synonym: Urethral Fistula
Synonym: Urethral fistula (disorder)
Synonym: Urethral fistula NOS
Synonym: Urethral fistula NOS (disorder)
Synonym: Urethral fistula, NOS
Synonym: urethral fistula
Synonym: urethral fistula (diagnosis)
Tree Number: T3.14.4.3
database_cross_reference: CCPSS:0035394
database_cross_reference: CHV:0000012767
database_cross_reference: DXP:U004222
database_cross_reference: HPO:HP:0010480
database_cross_reference: ICD10:N36.0
database_cross_reference: ICD10AM:N36.0
database_cross_reference: ICD10CM:N36.0
database_cross_reference: ICD9CM:599.1
database_cross_reference: MDR:10046451
database_cross_reference: MEDCIN:330492
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78668
database_cross_reference: RCD:K191.
database_cross_reference: RCD:K191z
database_cross_reference: SNMI:D7-23510
database_cross_reference: SNOMEDCT_US:14981000
database_cross_reference: SNOMEDCT_US:197933005
database_cross_reference: SNOMEDCT_US:236696008

Amniotic constriction rings of arms
type: Class
subclass of: Abnormality of the upper limb
definition: Amniotic constriction rings affecting the arms.
PMOID: PMO:00003341
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.7
database_cross_reference: HPO:HP:0010483

Hypertrophy of the upper limb
type: Class
subclass of: Abnormality of the upper limb
definition: Abnormal increase in size of the upper limbs (due to an increase of the size of cells).
PMOID: PMO:00003445
Subclass_of: Abnormality of the upper limb
Synonym: Increased size of upper limb
Tree Number: T3.5.4.11
database_cross_reference: HPO:HP:0010484

Amniotic constriction rings of legs
type: Class
subclass of: Abnormality of the lower limb
definition: Amniotic constriction rings affecting the legs.
PMOID: PMO:00002820
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.6
database_cross_reference: HPO:HP:0010495

Hypertrophy of the lower limb
type: Class
subclass of: Abnormality of the lower limb
definition: Abnormal increase in size of the lower limbs (due to an increase of the size of cells).
PMOID: PMO:00002827
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.9
database_cross_reference: HPO:HP:0010496

Sirenomelia
type: Class
subclass of: Abnormality of the lower limb
definition: A developmental defect in which the legs are fused together.
PMOID: PMO:00002830
Subclass_of: Abnormality of the lower limb
Synonym: (Sirenomelia (& [mermaid] or [sympus])
Synonym: (Sirenomelia (& [mermaid] or [sympus]) (disorder)
Synonym: Fused Legs and Feet
Synonym: Malformation, Mermaid
Synonym: Mermaid Malformation
Synonym: Mermaid Syndrome
Synonym: Mermaid sirenomelia
Synonym: Mermaid sirenomelia (disorder)
Synonym: Mermaid syndrome
Synonym: SIRENOMELIA
Tree Number: T3.5.2.12
database_cross_reference: CHV:0000011373
database_cross_reference: HPO:HP:0010497
database_cross_reference: MDR:10049216
database_cross_reference: MDR:10072457
database_cross_reference: MDR:10072464
database_cross_reference: MSH:D004480
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C118455
database_cross_reference: NCI_CDISC:C118455
database_cross_reference: NCI_NICHD:C118455
database_cross_reference: OMIM:600145
database_cross_reference: RCD:X77rt
database_cross_reference: RCD:XE2R4
database_cross_reference: SNM:M-28210
database_cross_reference: SNMI:D4-01561
database_cross_reference: SNMI:D4-F1110
database_cross_reference: SNOMEDCT_US:205815002
database_cross_reference: SNOMEDCT_US:253191000
database_cross_reference: SNOMEDCT_US:67254002
database_cross_reference: SNOMEDCT_US:91089008

Aplasia/Hypoplasia of the thymus
type: Class
subclass of: Abnormality of the thymus
definition: Absence or underdevelopment of the thymus.
PMOID: PMO:00006281
Subclass_of: Abnormality of the thymus
Synonym: Absent/small thymus
Synonym: Absent/underdeveloped thymus
Tree Number: T3.12.9.1
database_cross_reference: HPO:HP:0010515

Thymus hyperplasia
type: Class
subclass of: Abnormality of the thymus
definition: Enlargement of the thymus.
PMOID: PMO:00006288
Subclass_of: Abnormality of the thymus
Synonym: Enlarged thymus
Synonym: Gland Hyperplasia, Thymus
Synonym: Gland Hyperplasias, Thymus
Synonym: Hyperplasia of Thymus Gland
Synonym: Hyperplasia, Thymic
Synonym: Hyperplasia, Thymus
Synonym: Hyperplasias, Thymic
Synonym: Thymic Hyperplasia
Synonym: Thymic Hyperplasias
Synonym: Thymus Gland Hyperplasia
Tree Number: T3.12.9.5
database_cross_reference: CHV:0000012252
database_cross_reference: HPO:HP:0010516
database_cross_reference: MSH:D013952
database_cross_reference: NDFRT:N0000002938

Ectopic thymus tissue
type: Class
subclass of: Abnormality of the thymus
definition: The presence of ectopic thymus tissue. Normally, cells of the ventral bud of the third pharyngeal pouch detach and migrate in the eighth gestational week caudally and medially towards the location of the mature thyroid. They migrate further retrosternally into the superior mediastinum. There are two main ways ectopic thymus tissue can develop. Either cells detach along the descensus path and proliferate, thereby forming accessory thymus tissue, or the entire gland fails to descend.
PMOID: PMO:00006284
Subclass_of: Abnormality of the thymus
Synonym: Abnormal thymus position
Tree Number: T3.12.9.2
database_cross_reference: HPO:HP:0010517

Increased fetal movement
type: Class
subclass of: Prenatal movement abnormality
definition: An abnormal increase in quantity or strength of fetal movements.
PMOID: PMO:00004413
Subclass_of: Prenatal movement abnormality
Synonym: Fetal hyperkinesia
Tree Number: T3.7.12.2
database_cross_reference: HPO:HP:0010519

Hamartoma
type: Class
subclass of: Neoplasm by histology
definition: A disordered proliferation of mature tissues that is native to the site of origin, e.g., exostoses, nevi and soft tissue hamartomas. Although most hamartomas are benign, some histologic subtypes, e.g., neuromuscular hamartoma, may proliferate aggressively such as mesenchymal cystic hamartoma, Sclerosing epithelial hamartoma, Sclerosing metanephric hamartoma.
PMOID: PMO:00014319
Subclass_of: Neoplasm by histology
Synonym: 755-756 HAMARTOMAS
Synonym: HAMARTOMA
Synonym: HAMARTOMAS
Synonym: Hamartoma (disorder)
Synonym: Hamartoma (morphologic abnormality)
Synonym: Hamartoma NOS
Synonym: Hamartoma [Disease/Finding]
Synonym: Hamartoma, NOS
Synonym: Hamartomas
Synonym: Hamartomatous
Tree Number: T3.25.2.4
database_cross_reference: CCPSS:0053735
database_cross_reference: CHV:0000005784
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:3462
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0010566
database_cross_reference: LCH_NW:sh2008009753
database_cross_reference: MDR:10019105
database_cross_reference: MDR:10061193
database_cross_reference: MSH:D006222
database_cross_reference: NCI:C3075
database_cross_reference: NCI_CDISC:C3075
database_cross_reference: NCI_NCI-GLOSS:CDR0000044500
database_cross_reference: NDFRT:N0000001405
database_cross_reference: RCD:Xa1y1
database_cross_reference: SNM:M-75500
database_cross_reference: SNM:U000378
database_cross_reference: SNMI:M-75500
database_cross_reference: SNOMEDCT_US:400006008
database_cross_reference: SNOMEDCT_US:51398009

Neoplasm of the skeletal system
type: Class
subclass of: Neoplasm by anatomical site
definition: A tumor (abnormal growth of tissue) of the skeleton.
PMOID: PMO:00014241
Subclass_of: Neoplasm by anatomical site
Synonym: Neoplasm of skeletal system
Synonym: Neoplasm of skeletal system (disorder)
Synonym: Skeletal tumor
Synonym: neoplasm of skeletal system (diagnosis)
Tree Number: T3.25.1.10
database_cross_reference: HPO:HP:0010622
database_cross_reference: MEDCIN:355858
database_cross_reference: SNOMEDCT_US:442868003

Conjunctival amyloidosis
type: Class
subclass of: Amyloidosis
definition: A form of amyloidosis that affects the conjunctiva.
PMOID: PMO:00004244
Subclass_of: Amyloidosis
Synonym: Conjunctival amyloidosis (disorder)
Tree Number: T3.6.24.4
database_cross_reference: HPO:HP:0010637
database_cross_reference: RCD:X00Zv
database_cross_reference: SNMI:D6-94654
database_cross_reference: SNOMEDCT_US:59017008

Epiphyseal stippling
type: Class
subclass of: Ectopic calcification
definition: The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses.
PMOID: PMO:00014004
Subclass_of: Ectopic calcification
Synonym: CHONDRODYSTROPHIA CALCIFICANS CONGEN
Synonym: Chondrdys punct stipl epiph gr
Synonym: Chondrodysplasia Punctata
Synonym: Chondrodysplasia Punctata (Stippled Epiphyses) Group
Synonym: Chondrodysplasia Punctata [Disease/Finding]
Synonym: Chondrodysplasia calcificans
Synonym: Chondrodysplasia calcificans congenita
Synonym: Chondrodysplasia punctata
Synonym: Chondrodysplasia punctata (disorder)
Synonym: Chondrodysplasia punctata (disorder) [Ambiguous]
Tree Number: T3.20.4.4
database_cross_reference: CHV:0000002898
database_cross_reference: DO:DOID:2581
database_cross_reference: HPO:HP:0010655
database_cross_reference: ICD10:Q77.3
database_cross_reference: ICD10AM:Q77.3
database_cross_reference: ICD10CM:Q77.3
database_cross_reference: MEDCIN:330544
database_cross_reference: MSH:D002806
database_cross_reference: MTH:U003262
database_cross_reference: NCI:C84632
database_cross_reference: NCI_NICHD:C84632
database_cross_reference: NDFRT:N0000000768
database_cross_reference: OMIM:MTHU050816
database_cross_reference: RCD:PG4C.
database_cross_reference: RCD:Xa0pI
database_cross_reference: SNM:M-22410
database_cross_reference: SNM:M-22750
database_cross_reference: SNMI:D4-00A60
database_cross_reference: SNOMEDCT_US:205486004
database_cross_reference: SNOMEDCT_US:22932004
database_cross_reference: SNOMEDCT_US:278715001
database_cross_reference: SNOMEDCT_US:360507004
database_cross_reference: SNOMEDCT_US:42778005

Spontaneous rupture of the globe
type: Class
subclass of: Abnormal eye morphology
definition: Rupture of the eyeball not due to trauma.
PMOID: PMO:00007001
Subclass_of: Abnormal eye morphology
Tree Number: T3.13.1.11
database_cross_reference: HPO:HP:0010727

Ectopic calcification
type: Class
subclass of: Abnormality of the skeletal system
definition: Deposition of calcium salts in a tissue or location in which calcification does not normally occur.
PMOID: PMO:00013998
Subclass_of: Abnormality of the skeletal system
Tree Number: T3.20.4
database_cross_reference: HPO:HP:0010766

Urinary tract neoplasm
type: Class
subclass of: Neoplasm of the genitourinary tract
definition: The presence of a neoplasm of the urinary system.
PMOID: PMO:00008225
Subclass_of: Neoplasm of the genitourinary tract
Synonym: NEOPL UROL
Synonym: Neoplasm of Urinary System
Synonym: Neoplasm of Urinary Tract
Synonym: Neoplasm of the Urinary System
Synonym: Neoplasm of the Urinary Tract
Synonym: Neoplasm of urinary system
Synonym: Neoplasm of urinary system (disorder)
Synonym: Neoplasm of urinary tract
Synonym: Neoplasm of urinary tract (disorder)
Synonym: Neoplasm of urinary tract proper
Tree Number: T3.14.3.4
database_cross_reference: AOD:0000023077
database_cross_reference: CHV:0000012807
database_cross_reference: CSP:2021-0179
database_cross_reference: DO:DOID:731
database_cross_reference: HPO:HP:0010786
database_cross_reference: ICPC2P:U79002
database_cross_reference: MDR:10046583
database_cross_reference: MDR:10061398
database_cross_reference: MSH:D014571
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3431
database_cross_reference: NDFRT:N0000003087
database_cross_reference: RCD:X78Ys
database_cross_reference: RCDAE:X78Ys
database_cross_reference: SNOMEDCT_US:126879004
database_cross_reference: SNOMEDCT_US:254913005

Genital neoplasm
type: Class
subclass of: Neoplasm of the genitourinary tract
definition: A tumor (abnormal growth of tissue) of the genital system.
PMOID: PMO:00008204
Subclass_of: Neoplasm of the genitourinary tract
Synonym: Genital tumor
Synonym: genital neoplasm
Synonym: genital neoplasms
Tree Number: T3.14.3.2
database_cross_reference: AOD:0000023081
database_cross_reference: CHV:0000043055
database_cross_reference: HPO:HP:0010787

Abdominal wall defect
type: Class
subclass of: Abnormality of the abdominal wall
definition: An incomplete closure of the abdominal wall.
PMOID: PMO:00005542
Subclass_of: Abnormality of the abdominal wall
Synonym: ABDOMINAL WALL DEFECT
Synonym: ABDOMINAL WALL DEFECTS
Synonym: Congenital anterior abdominal wall defect
Synonym: abdominal defects wall
Synonym: abdominal wall defect
Synonym: abdominal wall defects
Tree Number: T3.10.5.1
database_cross_reference: CHV:0000024059
database_cross_reference: DXP:U000059
database_cross_reference: HPO:HP:0010866
database_cross_reference: OMIM:230750

Abnormality of circulating protein level
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormal level of a circulating protein in the blood.
PMOID: PMO:00003915
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.12

Abnormality of the umbilical cord
type: Class
subclass of: Abnormalities of placenta or umbilical cord
definition: An abnormality of the umbilical cord, which is the cord connecting the developing embryo or fetus to the placenta.
PMOID: PMO:00004328
Subclass_of: Abnormalities of placenta or umbilical cord
Synonym: 4-F5 ANOMALIES OF THE UMBILICAL CORD
Synonym: ANOMALIES OF THE UMBILICAL CORD
Synonym: Abnormal umbilical cord
Synonym: Abnormal umbilical cord (disorder)
Synonym: Abnormal umbilical cord, NOS
Synonym: Abnormalities of Umbilical Cord
Synonym: Umbilical cord abnormality
Synonym: Umbilical cord abnormality NOS
Synonym: Umbilical cord, abnormal
Synonym: abnormal cord umbilical
Tree Number: T3.7.2.3
database_cross_reference: CHV:0000026094
database_cross_reference: HPO:HP:0010881
database_cross_reference: MDR:10045446
database_cross_reference: MDR:10048596
database_cross_reference: MEDCIN:354830
database_cross_reference: MEDCIN:354831
database_cross_reference: SNM:M-29600
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-F5000
database_cross_reference: SNOMEDCT_US:90009001

Acromelia
type: Class
subclass of: Aplasia/hypoplasia of the extremities
definition: Shortening of the extremities affecting primarily the distal parts of the limbs (hands and feet) in relation to the other segments of the limbs.
PMOID: PMO:00003449
Subclass_of: Aplasia/hypoplasia of the extremities
Tree Number: T3.5.5.1
database_cross_reference: HPO:HP:0010884

Aseptic necrosis
type: Class
subclass of: Abnormality of skeletal physiology
definition: A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply.
PMOID: PMO:00013974
Subclass_of: Abnormality of skeletal physiology
Synonym: Aseptic Necrosis of Head and Neck of Femur
Synonym: Aseptic necrosis femur
Synonym: Aseptic necrosis of head AND/OR neck of femur
Synonym: Aseptic necrosis of head AND/OR neck of femur (disorder)
Synonym: Aseptic necrosis of head and neck of femur
Synonym: Aseptic necrosis of head and/or neck of femur
Synonym: Avascular necrosis of bone
Synonym: aseptic necrosis
Synonym: bone necrosis
Synonym: osteonecrosis
Tree Number: T3.20.2.2
database_cross_reference: DO:DOID:10159
database_cross_reference: ICD9CM:733.42
database_cross_reference: MDR:10003463
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34404
database_cross_reference: SNMI:D1-61654
database_cross_reference: SNOMEDCT_US:29281007

Abnormality of cation homeostasis
type: Class
subclass of: Abnormality of ion homeostasis
definition: An abnormality of cation homeostasis.
PMOID: PMO:00004006
Subclass_of: Abnormality of ion homeostasis
Tree Number: T3.6.15.1
database_cross_reference: HPO:HP:0010929

Abnormality of nucleobase metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality of a nucleobase metabolic process.
PMOID: PMO:00004165
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.19
database_cross_reference: HPO:HP:0010932

Abnormality of the upper urinary tract
type: Class
subclass of: Abnormality of the urinary system
definition: An abnormality of the upper urinary tract.
PMOID: PMO:00007864
Subclass_of: Abnormality of the urinary system
Tree Number: T3.14.2.2
database_cross_reference: HPO:HP:0010935

Abnormality of the lower urinary tract
type: Class
subclass of: Abnormality of the urinary system
definition: An abnormality of the lower urinary tract.
PMOID: PMO:00007796
Subclass_of: Abnormality of the urinary system
Tree Number: T3.14.2.1
database_cross_reference: HPO:HP:0010936

Echogenic intracardiac focus
type: Class
subclass of: Abnormality of the fetal cardiovascular system
definition: A finding of a focus of increased echogenicity upon prenatal ultrasound examination of the fetus. The foci may be present in one or both ventricles. Echogenic intracardiac focus (EICF) is defined as a focus of echogenicity comparable to bone, in the region of the papillary muscle in either or both ventricles of the fetal heart.
PMOID: PMO:00004966
Subclass_of: Abnormality of the fetal cardiovascular system
Tree Number: T3.9.4.4
database_cross_reference: HPO:HP:0010942

Echogenic fetal bowel
type: Class
subclass of: Fetal ultrasound soft marker
definition: Echogenic bowel is defined as fetal bowel with homogenous areas of echogenicity that are equal to or greater than that of surrounding bone.
PMOID: PMO:00004355
Subclass_of: Fetal ultrasound soft marker
Synonym: Echogenic Bowel
Synonym: Echogenic Bowel [Disease/Finding]
Synonym: Echogenic Bowels
Synonym: Echogenic bowel
Synonym: Hyperechogenic Bowel
Synonym: Hyperechogenic Bowels
Tree Number: T3.7.6.2
database_cross_reference: HPO:HP:0010943
database_cross_reference: MSH:D058535
database_cross_reference: NDFRT:N0000182249

Abnormality of ductus venosus blood flow
type: Class
subclass of: Abnormality of the fetal cardiovascular system
definition: An first-trimester prenatal ultrasound finding of abnormal blood flow in the ductus venosus.
PMOID: PMO:00004963
Subclass_of: Abnormality of the fetal cardiovascular system
Tree Number: T3.9.4.1
database_cross_reference: HPO:HP:0010947

Abnormality of the fetal cardiovascular system
type: Class
subclass of: Abnormality of the cardiovascular system
definition: An abnormality of the fetal circulation system or fetal echocardiogram.
PMOID: PMO:00004962
Subclass_of: Abnormality of the cardiovascular system
Synonym: Abnormality of the fetal circulation system
Tree Number: T3.9.4
database_cross_reference: HPO:HP:0010948

Abnormality of umbilical vein blood flow
type: Class
subclass of: Abnormality of the fetal cardiovascular system
definition: An first-trimester prenatal ultrasound finding of abnormal blood flow in the umbilical vein.
PMOID: PMO:00004964
Subclass_of: Abnormality of the fetal cardiovascular system
Tree Number: T3.9.4.2
database_cross_reference: HPO:HP:0010949

Absence of stomach bubble on fetal sonography
type: Class
subclass of: Fetal ultrasound soft marker
definition: By the 14th week of gestation it is nearly always possible to visualized the fluid-filled fetal stomach bubble on prenatal sonography. This term refers to the absence of a normal fetal stomach bubble on fetal ultrasonography performed at around 16 to 20 weeks' gestation.
PMOID: PMO:00004354
Subclass_of: Fetal ultrasound soft marker
Tree Number: T3.7.6.1
database_cross_reference: HPO:HP:0010963

Abnormality of liposaccharide metabolism
type: Class
subclass of: Abnormality of lipid metabolism
definition: An abnormality of liposaccharide metabolism.
PMOID: PMO:00004123
Subclass_of: Abnormality of lipid metabolism
Tree Number: T3.6.17.4
database_cross_reference: HPO:HP:0010968

Blood group antigen abnormality
type: Class
subclass of: Abnormal erythrocyte morphology
definition: An abnormality of an erythrocyte cell surface molecule.
PMOID: PMO:00001010
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.12
database_cross_reference: HPO:HP:0010970

Abnormality of immune system physiology
type: Class
subclass of: Abnormality of the immune system
definition: A functional abnormality of the immune system.
PMOID: PMO:00008378
Subclass_of: Abnormality of the immune system
Tree Number: T3.15.2
database_cross_reference: HPO:HP:0010978

Abnormality of cellular immune system
type: Class
subclass of: Abnormality of the immune system
definition: An abnormality of the morphology or counts of the cells that make up the immune system.
PMOID: PMO:00008250
Subclass_of: Abnormality of the immune system
Tree Number: T3.15.1
database_cross_reference: HPO:HP:0010987

Abnormality of the abdominal musculature
type: Class
subclass of: Abnormality of the abdominal wall
definition: An abnormality of the abdominal musculature.
PMOID: PMO:00005547
Subclass_of: Abnormality of the abdominal wall
Tree Number: T3.10.5.2
database_cross_reference: HPO:HP:0010991

Abnormality of dicarboxylic acid metabolism
type: Class
subclass of: Abnormality of carboxylic acid metabolism
definition: An abnormality of dicarboxylic acid metabolism.
PMOID: PMO:00003894
Subclass_of: Abnormality of carboxylic acid metabolism
Tree Number: T3.6.11.2
database_cross_reference: HPO:HP:0010995

Abnormality of monocarboxylic acid metabolism
type: Class
subclass of: Abnormality of carboxylic acid metabolism
definition: An abnormality of monocarboxylic acid metabolism.
PMOID: PMO:00003900
Subclass_of: Abnormality of carboxylic acid metabolism
Tree Number: T3.6.11.3
database_cross_reference: HPO:HP:0010996

Abnormality of the musculature of the neck
type: Class
subclass of: Abnormality of the musculature
definition: An abnormality of the neck musculature.
PMOID: PMO:00009725
Subclass_of: Abnormality of the musculature
Synonym: Abnormality of cervical musculature
Tree Number: T3.17.9
database_cross_reference: HPO:HP:0011006

Abnormality of polysaccharide metabolism
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An abnormality of the metabolism of polysaccharide.
PMOID: PMO:00003718
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.7
database_cross_reference: HPO:HP:0011012

Abnormality of carbohydrate metabolism/homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality of the metabolism/homeostasis of a carbohydrate.
PMOID: PMO:00003641
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.10
database_cross_reference: HPO:HP:0011013

Abnormal glucose homeostasis
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: Abnormality of glucose homeostasis.
PMOID: PMO:00003645
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.2
database_cross_reference: HPO:HP:0011014

Abnormal cellular physiology
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality in a cellular process.
PMOID: PMO:00003476
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.2

Abnormality of the cell cycle
type: Class
subclass of: Abnormal cellular physiology
definition: An abnormality of the cell cycle.
PMOID: PMO:00003500
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.8
database_cross_reference: HPO:HP:0011018

Abnormality of chromosome condensation
type: Class
subclass of: Abnormal cellular physiology
definition: An abnormality of chromosome condensation.
PMOID: PMO:00003478
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.2
database_cross_reference: HPO:HP:0011019

Abnormality of circulating enzyme level
type: Class
subclass of: Abnormality of circulating protein level
PMOID: PMO:00003951
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.11
database_cross_reference: HPO:HP:0011021

Abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the digestive system
definition: An abnormality of the gastrointestinal tract.
PMOID: PMO:00005561
Subclass_of: Abnormality of the digestive system
Tree Number: T3.10.6
database_cross_reference: HPO:HP:0011024

Abnormality of cardiovascular system physiology
type: Class
subclass of: Abnormality of the cardiovascular system
definition: Abnormal functionality of the cardiovascular system.
PMOID: PMO:00004713
Subclass_of: Abnormality of the cardiovascular system
Tree Number: T3.9.3
database_cross_reference: HPO:HP:0011025

Abnormality of blood circulation
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: An abnormality of blood circulation.
PMOID: PMO:00004807
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.8

Abnormality of fluid regulation
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality of the regulation of body fluids.
PMOID: PMO:00003974
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Disorder of fluid balance
Synonym: Disorder;fluids
Synonym: Fluid imbalance
Synonym: Fluid imbalance (disorder)
Synonym: Fluid volume alteration
Synonym: Fluid volume alteration (finding)
Synonym: Fluid volume disorder
Synonym: Fluid volume disorder (disorder)
Synonym: Fluid volume disorder, NOS
Synonym: VOLUME DISORDER
Tree Number: T3.6.13
database_cross_reference: CHV:0000026243
database_cross_reference: CHV:0000049781
database_cross_reference: CST:PATHVOLDIS
database_cross_reference: HPO:HP:0011032
database_cross_reference: ICPC2P:T99009
database_cross_reference: LNC:MTHU013361
database_cross_reference: MDR:10051283
database_cross_reference: MEDCIN:314405
database_cross_reference: RCD:C36z2
database_cross_reference: RCD:X208k
database_cross_reference: SNMI:D6-20100
database_cross_reference: SNOMEDCT_US:129848002
database_cross_reference: SNOMEDCT_US:1860003
database_cross_reference: SNOMEDCT_US:190902006

Impairment of fructose metabolism
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An impairment of a fructose metabolic process.
PMOID: PMO:00003738
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.14
database_cross_reference: HPO:HP:0011033

Amyloidosis
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: The presence of amyloid deposition in one or more tissues. Amyloidosis may be defined as the extracellular deposition of amyloid in one or more sites of the body.
PMOID: PMO:00004238
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: AMYLOID
Synonym: AMYLOIDOSIS
Synonym: Amyloid disease
Synonym: Amyloidoses
Synonym: Amyloidosis (disorder)
Synonym: Amyloidosis NOS
Synonym: Amyloidosis NOS (disorder)
Synonym: Amyloidosis [Disease/Finding]
Synonym: Amyloidosis, NOS
Synonym: Amyloidosis, unspecified
Tree Number: T3.6.24
database_cross_reference: AOD:0000005846
database_cross_reference: CCPSS:0052113
database_cross_reference: CHV:0000001070
database_cross_reference: COSTAR:U000030
database_cross_reference: CSP:1849-1519
database_cross_reference: CST:AMYLOIDOSIS
database_cross_reference: CST:PATHAMYLOID
database_cross_reference: DO:DOID:9120
database_cross_reference: HPO:HP:0011034
database_cross_reference: ICD10:E85
database_cross_reference: ICD10:E85.9
database_cross_reference: ICD10AM:E85
database_cross_reference: ICD10AM:E85.9
database_cross_reference: ICD10CM:E85
database_cross_reference: ICD10CM:E85.9
database_cross_reference: ICD9CM:277.3
database_cross_reference: ICD9CM:277.30
database_cross_reference: ICPC2P:T99006
database_cross_reference: LCH:U000219
database_cross_reference: LCH_NW:sh85004724
database_cross_reference: MDR:10002021
database_cross_reference: MDR:10002022
database_cross_reference: MDR:10002023
database_cross_reference: MDR:10002024
database_cross_reference: MEDCIN:31790
database_cross_reference: MEDLINEPLUS:5273
database_cross_reference: MSH:D000686
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:277.30
database_cross_reference: NCI:C2868
database_cross_reference: NCI_CDISC:C2868
database_cross_reference: NCI_CDISC:SEND-NONNEO
database_cross_reference: NCI_CTEP-SDC:10002024
database_cross_reference: NCI_NCI-GLOSS:CDR0000045507
database_cross_reference: NDFRT:N0000000375
database_cross_reference: PDQ:CDR0000041926
database_cross_reference: RCD:C373.
database_cross_reference: RCD:C373z
database_cross_reference: SNM:D-3890
database_cross_reference: SNMI:D6-94500
database_cross_reference: SNOMEDCT_US:154769007
database_cross_reference: SNOMEDCT_US:17602002
database_cross_reference: SNOMEDCT_US:190931005

Abnormality of circulating adrenocorticotropin level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An abnormal concentration of corticotropin in the blood.
PMOID: PMO:00006175
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.12
database_cross_reference: HPO:HP:0011043

Abnormality of immune serum protein physiology
type: Class
subclass of: Abnormality of immune system physiology
definition: An abnormality of the concentration or function of circulating immune proteins.
PMOID: PMO:00008553
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.6
database_cross_reference: HPO:HP:0011111

Abnormality of skin morphology
type: Class
subclass of: Abnormality of the skin
definition: Any morphological abnormality of the skin.
PMOID: PMO:00008955
Subclass_of: Abnormality of the skin
Synonym: Abnormal skin structure
Tree Number: T3.16.3.1
database_cross_reference: HPO:HP:0011121

Abnormality of skin physiology
type: Class
subclass of: Abnormality of the skin
definition: Any abnormality of the physiological function of the skin.
PMOID: PMO:00009408
Subclass_of: Abnormality of the skin
Tree Number: T3.16.3.2
database_cross_reference: HPO:HP:0011122

Increased sensitivity to ionizing radiation
type: Class
subclass of: Abnormal cellular physiology
definition: An abnormally increased sensitivity to the effects of ionizing radiation.
PMOID: PMO:00003530
Subclass_of: Abnormal cellular physiology
Synonym: Increased sensitivity to ionising radiation
Tree Number: T3.6.2.11
database_cross_reference: HPO:HP:0011133

Abnormality of skin adnexa morphology
type: Class
subclass of: Abnormality of the integument
definition: An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands.
PMOID: PMO:00008731
Subclass_of: Abnormality of the integument
Tree Number: T3.16.1

Elevated C-reactive protein level
type: Class
subclass of: Abnormality of circulating protein level
definition: An abnormal elevation of the C-reactive protein level in serum.
PMOID: PMO:00003960
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.14
database_cross_reference: HPO:HP:0011227

Anisocytosis
type: Class
subclass of: Abnormal erythrocyte morphology
definition: Abnormally increased variability in the size of erythrocytes.
PMOID: PMO:00001009
Subclass_of: Abnormal erythrocyte morphology
Synonym: Unequal size of red blood cells
Tree Number: T3.2.2.11
database_cross_reference: HPO:HP:0011273

Abnormality of the urinary system physiology
type: Class
subclass of: Abnormality of the urinary system
PMOID: PMO:00008065
Subclass_of: Abnormality of the urinary system
Tree Number: T3.14.2.3
database_cross_reference: HPO:HP:0011277

Abnormality of placental membranes
type: Class
subclass of: Abnormalities of placenta or umbilical cord
PMOID: PMO:00004314
Subclass_of: Abnormalities of placenta or umbilical cord
Tree Number: T3.7.2.1
database_cross_reference: HPO:HP:0011409

Caesarian section
type: Class
subclass of: Abnormal delivery
definition: Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy).
PMOID: PMO:00004298
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.2
database_cross_reference: HPO:HP:0011410

Forceps delivery
type: Class
subclass of: Abnormal delivery
PMOID: PMO:00004302
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.4
database_cross_reference: HPO:HP:0011411

Ventouse delivery
type: Class
subclass of: Abnormal delivery
definition: Delivery of newborn by means of a ventouse, a vacuum device used to assist the delivery of a baby when the second stage of labour has not progressed adequately.
PMOID: PMO:00004312
Subclass_of: Abnormal delivery
Synonym: Vacuum extraction
Synonym: Vacuum-assisted vaginal delivery
Tree Number: T3.7.1.12
database_cross_reference: HPO:HP:0011412

Shoulder dystocia
type: Class
subclass of: Abnormal delivery
definition: Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex.
PMOID: PMO:00004307
Subclass_of: Abnormal delivery
Synonym: Impacted shoulders
Synonym: Impacted shoulders during labor
Synonym: SHOULDER DYSTOCIA
Synonym: SHOULDER DYSTOCIA UNSPECIFIED
Synonym: Shoulder (girdle) dystocia during labor and delivery
Synonym: Shoulder (girdle) dystocia during labour and delivery
Synonym: Shoulder Dystocia
Synonym: Shoulder dystocia NOS
Synonym: Shoulder dystocia NOS (disorder)
Synonym: Shoulder dystocia unspecified
Tree Number: T3.7.1.8
database_cross_reference: CCPSS:0019883
database_cross_reference: CCPSS:0043691
database_cross_reference: CHV:0000026443
database_cross_reference: HPO:HP:0011413
database_cross_reference: ICD10CM:O66.0
database_cross_reference: ICD9CM:660.4
database_cross_reference: LCH_NW:sh90006064
database_cross_reference: MDR:10040605
database_cross_reference: MDR:10040606
database_cross_reference: MDR:10040613
database_cross_reference: MEDCIN:35355
database_cross_reference: MTHICD9:660.4
database_cross_reference: NCI:C81290
database_cross_reference: NCI_NICHD:C81290
database_cross_reference: RCD:L305.
database_cross_reference: RCD:L3050
database_cross_reference: RCD:L305z
database_cross_reference: SNMI:D8-30142
database_cross_reference: SNOMEDCT_US:199782009
database_cross_reference: SNOMEDCT_US:199785006
database_cross_reference: SNOMEDCT_US:89700002

Abnormality of chloride homeostasis
type: Class
subclass of: Abnormality of ion homeostasis
definition: An abnormality of chloride homeostasis or concentration in the body.
PMOID: PMO:00004050
Subclass_of: Abnormality of ion homeostasis
Tree Number: T3.6.15.2
database_cross_reference: HPO:HP:0011422

Fetal ultrasound soft marker
type: Class
subclass of: Abnormality of prenatal development or birth
definition: An finding upon obstetric ultrasound examination performed at around 16 to 20 weeks of gestation that is abnormal but not clearly identifiable as a fetal anatomic malformation or growth restriction. Such findings are known as soft markers since they are associated with increased risk for fetal aneuploidy or other disorders.
PMOID: PMO:00004353
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.6
database_cross_reference: HPO:HP:0011425

Fetal choroid plexus cysts
type: Class
subclass of: Fetal ultrasound soft marker
definition: Fetal choroid plexus cysts (CPCs) are sonographically discrete, small cysts (3 mm or more) found in the choroid plexus within the lateral cerebral ventricles of the developing fetus at 14 to 24 weeks gestation. Imaging of the choroid plexus is performed in the transverse plane of the fetal head at the same level that the lateral cerebral ventricle is evaluated. The choroid plexus should be inspected bilaterally for the presence of cysts. The size of CPCs is not of clinical relevance (pmid:16100637).
PMOID: PMO:00004357
Subclass_of: Fetal ultrasound soft marker
Tree Number: T3.7.6.4
database_cross_reference: HPO:HP:0011426

Enlarged fetal cisterna magna
type: Class
subclass of: Fetal ultrasound soft marker
definition: The cisterna magna is measured on a transaxial view of the fetal head angled 15 degrees caudal to the canthomeatal line. The anterior/posterior diameter is taken between the inferior/posterior surface of the vemis of the cerebellum to the inner surface of the cranium. An enlarged cisternal magna is defined by an anterior/posterior diameter of 10 mm or more (pmid:16100637).
PMOID: PMO:00004356
Subclass_of: Fetal ultrasound soft marker
Tree Number: T3.7.6.3
database_cross_reference: HPO:HP:0011427

Short fetal femur length
type: Class
subclass of: Fetal ultrasound soft marker
definition: A short femur length is defined as either a measurement below the 2.5th percentile for gestational age or a measurement that is less than 0.9 of that predicted by the measured biparietal diameter. The femur should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (pmid:16100637).
PMOID: PMO:00004360
Subclass_of: Fetal ultrasound soft marker
Synonym: Short fetal thigh bone length
Tree Number: T3.7.6.7
database_cross_reference: HPO:HP:0011428

Short fetal humerus length
type: Class
subclass of: Fetal ultrasound soft marker
definition: A short humerus length is defined as a length below the 2.5th percentile for gestational age or as a measurement less than 0.9 of that predicted by the measured biparietal diameter. The humerus should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (pmid:16100637).
PMOID: PMO:00004361
Subclass_of: Fetal ultrasound soft marker
Synonym: Short fetal long bone in upper arm length
Tree Number: T3.7.6.8
database_cross_reference: HPO:HP:0011429

Hypoplasia of fetal nasal bone
type: Class
subclass of: Fetal ultrasound soft marker
definition: On prenatal ultrasound, the nasal bone is a thin echogenic line within the bridge of the fetal nose. The fetus is imaged facing the transducer with the fetal face strictly in the midline. The angle of insonation is 90 degrees, with the longitudinal axis of the nasal bone as the reference line. Calibres are placed at each end of the nasal bone. Absence of the nasal bone or measurements below 2.5th percentile are considered significant (pmid:16100637).
PMOID: PMO:00004359
Subclass_of: Fetal ultrasound soft marker
Synonym: Underdeveloped fetal nose bone
Tree Number: T3.7.6.6
database_cross_reference: HPO:HP:0011430

Fetal fifth finger clinodactyly
type: Class
subclass of: Fetal ultrasound soft marker
definition: Fifth finger clinodactyly is defined by a hypoplastic or absent mid-phalanx of the fifth digit. Ultrasound identification of the fetal hand must first be undertaken and then appropriate magnification accomplished. The evaluation requires stretching of the 5 fingers. The diagnosis is established when the middle phalanx of the fifth finger is markedly smaller than normal or absent, which often causes the finger to be curved inward (pmid:16100637).
PMOID: PMO:00004358
Subclass_of: Fetal ultrasound soft marker
Tree Number: T3.7.6.5
database_cross_reference: HPO:HP:0011431

Abnormal maternal serum screening
type: Class
subclass of: Prenatal maternal abnormality
definition: An abnormally elevated or decreased level of a maternal serum marker analytes used in screening for aneuploidy.
PMOID: PMO:00004384
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.1
database_cross_reference: HPO:HP:0011436

Maternal autoimmune disease
type: Class
subclass of: Prenatal maternal abnormality
definition: A medical history of a fetus or child born to a mother with an autoimmune disease.
PMOID: PMO:00004393
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.4
database_cross_reference: HPO:HP:0011437

Abnormality of central motor function
type: Class
subclass of: Abnormality of nervous system physiology
definition: An anomaly of the control or production of movement in the central nervous system.
PMOID: PMO:00010701
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.6
database_cross_reference: HPO:HP:0011442

Abnormality of higher mental function
type: Class
subclass of: Abnormality of nervous system physiology
definition: Cognitive, psychiatric or memory anomaly.
PMOID: PMO:00010804
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.8
database_cross_reference: HPO:HP:0011446

Abdominal symptom
type: Class
subclass of: Abnormality of digestive system physiology
PMOID: PMO:00005319
Subclass_of: Abnormality of digestive system physiology
Synonym: ABDOMEN SYMPTOM
Synonym: Abdominal symptom NOS
Synonym: abdominal symptom
Synonym: abdominal symptoms
Tree Number: T3.10.3.1
database_cross_reference: CCPSS:0034346
database_cross_reference: CHV:0000047152
database_cross_reference: HPO:HP:0011458
database_cross_reference: MDR:10000095
database_cross_reference: MDR:10060926

Abnormal pulmonary situs morphology
type: Class
subclass of: Abnormal respiratory system morphology
definition: An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, which is defined by characteristics such as the number of lobes per lung and the relationship of the pulmonary arteries to their bronchi.
PMOID: PMO:00011470
Subclass_of: Abnormal respiratory system morphology
Tree Number: T3.19.1.2

Abnormality of abdominal situs
type: Class
subclass of: Heterotaxy
definition: An abnormality of the abdominal situs, i.e., of the sidedness of the abdomen and its organs.
PMOID: PMO:00014183
Subclass_of: Heterotaxy
Tree Number: T3.24.5.1
database_cross_reference: HPO:HP:0011620

Persistent fetal circulation
type: Class
subclass of: Abnormality of the fetal cardiovascular system
definition: Systemic desaturation of a liveborn baby resulting from persistent pulmonary hypertension with a patent ductus arteriosus and patent foramen ovale, such that the circulation in postnatal life follows the fetal course.
PMOID: PMO:00004967
Subclass_of: Abnormality of the fetal cardiovascular system
Synonym: (Persistent) pulmonary hypertension of newborn
Synonym: ACD MPV
Synonym: ACD-MPV
Synonym: ACDMPV
Synonym: ALVEOLAR CAPILLARY DYSPLASIA WITH MISALIGNMENT OF PULMONARY VEINS
Synonym: ALVEOLAR CAPILLARY DYSPLASIA WITH MISALIGNMENT OF PULMONARY VEINS AND OTHER CONGENITAL ANOMALIES
Synonym: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Synonym: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins And Other Congenital Anomalies
Synonym: CIRC PERSISTENT FETAL
Synonym: Circulation, Persistent Fetal
Tree Number: T3.9.4.5
database_cross_reference: CSP:0723-5955
database_cross_reference: CSP:2595-6954
database_cross_reference: DO:DOID:13042
database_cross_reference: DXP:U000645
database_cross_reference: DXP:U001469
database_cross_reference: HPO:HP:0011726
database_cross_reference: ICD10:P29.3
database_cross_reference: ICD10AM:P29.3
database_cross_reference: ICD10CM:P29.3
database_cross_reference: ICD9CM:747.83
database_cross_reference: ICPC2P:A94023
database_cross_reference: LCH_NW:sh90000431
database_cross_reference: MDR:10034708
database_cross_reference: MDR:10034709
database_cross_reference: MDR:10053592
database_cross_reference: MDR:10054726
database_cross_reference: MEDCIN:272370
database_cross_reference: MEDCIN:35814
database_cross_reference: MSH:D010547
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85006
database_cross_reference: NCI_NICHD:C85006
database_cross_reference: NDFRT:N0000002380
database_cross_reference: OMIM:265380
database_cross_reference: OMIM:601089
database_cross_reference: OMIM:MTHU046520
database_cross_reference: RCD:Q493.
database_cross_reference: RCD:X2001
database_cross_reference: SNM:D-7003
database_cross_reference: SNMI:D4-30010
database_cross_reference: SNOMEDCT_US:204507004
database_cross_reference: SNOMEDCT_US:206597007
database_cross_reference: SNOMEDCT_US:233815004
database_cross_reference: SNOMEDCT_US:35604006

Abnormality of central sensory function
type: Class
subclass of: Abnormality of nervous system physiology
definition: An abnormality of cortical sensation. Assuming the primary sensory modalities are intact and the patient is alert and cooperative, the presence of an abnormality of sensory function usually indicates a lesion of a parietal cortex or of the thalamocortical projections to the parietal cortex.
PMOID: PMO:00010799
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.7
database_cross_reference: HPO:HP:0011730

Abnormality of adrenal morphology
type: Class
subclass of: Abnormality of the adrenal glands
definition: Any structural anomaly of the adrenal glands.
PMOID: PMO:00006207
Subclass_of: Abnormality of the adrenal glands
Tree Number: T3.12.5.1
database_cross_reference: HPO:HP:0011732

Abnormality of adrenal physiology
type: Class
subclass of: Abnormality of the adrenal glands
definition: A functional abnormality of the adrenal glands.
PMOID: PMO:00006229
Subclass_of: Abnormality of the adrenal glands
Tree Number: T3.12.5.2
database_cross_reference: HPO:HP:0011733

Abnormality of the parathyroid morphology
type: Class
subclass of: Abnormality of the parathyroid gland
definition: A structural abnormality of the parathyroid gland.
PMOID: PMO:00006256
Subclass_of: Abnormality of the parathyroid gland
Tree Number: T3.12.7.1
database_cross_reference: HPO:HP:0011766

Abnormality of the parathyroid physiology
type: Class
subclass of: Abnormality of the parathyroid gland
definition: A functional abnormality of the parathyroid gland.
PMOID: PMO:00006262
Subclass_of: Abnormality of the parathyroid gland
Tree Number: T3.12.7.2
database_cross_reference: HPO:HP:0011767

Abnormality of thyroid morphology
type: Class
subclass of: Abnormality of the thyroid gland
definition: A structural abnormality of the thyroid gland.
PMOID: PMO:00006290
Subclass_of: Abnormality of the thyroid gland
Synonym: Abnormal shape of thyroid gland
Tree Number: T3.12.10.1
database_cross_reference: HPO:HP:0011772

Neoplasm by histology
type: Class
subclass of: Neoplasm
definition: Neoplasm categorized according to type of histological abnormality.
PMOID: PMO:00014292
Subclass_of: Neoplasm
Tree Number: T3.25.2
database_cross_reference: HPO:HP:0011792

Neoplasm by anatomical site
type: Class
subclass of: Neoplasm
definition: Neoplasm categorized according to the anatomical site of origin of the neoplasm.
PMOID: PMO:00014192
Subclass_of: Neoplasm
Tree Number: T3.25.1
database_cross_reference: HPO:HP:0011793

Abnormality of muscle physiology
type: Class
subclass of: Abnormality of the musculature
definition: A functional abnormality of a skeletal muscle.
PMOID: PMO:00009590
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.3
database_cross_reference: HPO:HP:0011804

Abnormal muscle morphology
type: Class
subclass of: Abnormality of the musculature
definition: A structural abnormality of a skeletal muscle.
PMOID: PMO:00009457
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.1

Abnormality of skeletal morphology
type: Class
subclass of: Abnormality of the skeletal system
definition: An abnormality of the form, structure, or size of the skeletal system.
PMOID: PMO:00011671
Subclass_of: Abnormality of the skeletal system
Synonym: Abnormally shaped skeletal
Tree Number: T3.20.1
database_cross_reference: HPO:HP:0011842

Abnormality of skeletal physiology
type: Class
subclass of: Abnormality of the skeletal system
definition: An abnormality of the function of the skeletal system.
PMOID: PMO:00013965
Subclass_of: Abnormality of the skeletal system
Tree Number: T3.20.2
database_cross_reference: HPO:HP:0011843

Abnormal appendicular skeleton morphology
type: Class
subclass of: Abnormality of skeletal morphology
definition: An abnormality of the appendicular skeletal system, consisting of the of the limbs, shoulder and pelvic girdles.
PMOID: PMO:00011672
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.1
database_cross_reference: HPO:HP:0011844

Plasmacytoma
type: Class
subclass of: Hematological neoplasm
definition: A discrete mass of neoplastic monoclonal plasma cells either in the bone marrow or in an extramedullary location.
PMOID: PMO:00001258
Subclass_of: Hematological neoplasm
Synonym: Extramedullary Plasmacytoma
Synonym: Extramedullary plasmacytoma
Synonym: Extramedullary plasmacytoma (clinical disorder) (disorder)
Synonym: Extramedullary plasmacytoma (clinical disorder) [Ambiguous]
Synonym: Extramedullary plasmacytoma (clinical)
Synonym: Extramedullary plasmacytoma NOS
Synonym: Extraosseous Plasmacytoma
Synonym: M plsma cel neo,extram p'cytom
Synonym: Malignant plasma cell neoplasm, extramedullary plasmacytoma
Synonym: Malignant plasma cell neoplasm, extramedullary plasmacytoma (disorder)
Tree Number: T3.2.10.7
database_cross_reference: CHV:0000027203
database_cross_reference: DO:DOID:3720
database_cross_reference: DO:DOID:3721
database_cross_reference: HPO:HP:0011857
database_cross_reference: ICD10:C90.2
database_cross_reference: ICD10AM:C90.2
database_cross_reference: ICD10CM:C90.2
database_cross_reference: ICD10CM:C90.20
database_cross_reference: MDR:10066883
database_cross_reference: MEDCIN:271576
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4002
database_cross_reference: NCI:TCGA
database_cross_reference: PDQ:CDR0000041865
database_cross_reference: RCD:B6300
database_cross_reference: SNMI:M-97313
database_cross_reference: SNOMEDCT_US:10639003
database_cross_reference: SNOMEDCT_US:109987008
database_cross_reference: SNOMEDCT_US:128921005
database_cross_reference: SNOMEDCT_US:188718006

Abnormal platelet function
type: Class
subclass of: Abnormal thrombocyte morphology
definition: Any anomaly in the function of thrombocytes.
PMOID: PMO:00001050
Subclass_of: Abnormal thrombocyte morphology
Tree Number: T3.2.5.2
database_cross_reference: HPO:HP:0011869

Abnormal platelet count
type: Class
subclass of: Abnormal thrombocyte morphology
definition: Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood.
PMOID: PMO:00001041
Subclass_of: Abnormal thrombocyte morphology
Tree Number: T3.2.5.1
database_cross_reference: HPO:HP:0011873

Abnormal platelet morphology
type: Class
subclass of: Abnormal thrombocyte morphology
definition: An anomaly in platelet form, ultrastructure, or intracellular organelles.
PMOID: PMO:00001084
Subclass_of: Abnormal thrombocyte morphology
Synonym: Abnormal shape of platelets
Tree Number: T3.2.5.3
database_cross_reference: HPO:HP:0011875

Abnormal platelet volume
type: Class
subclass of: Abnormal thrombocyte morphology
definition: Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers.
PMOID: PMO:00001098
Subclass_of: Abnormal thrombocyte morphology
Tree Number: T3.2.5.4
database_cross_reference: HPO:HP:0011876

Abnormal umbilical stump bleeding
type: Class
subclass of: Abnormal bleeding
definition: Abnormal bleeding of the umbilical stump following separation of the cord at approximately 7-10 days after birth.
PMOID: PMO:00000909
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.2
database_cross_reference: HPO:HP:0011884

Bleeding requiring red cell transfusion
type: Class
subclass of: Abnormal bleeding
definition: Bleeding sufficiently severe as to require red cell transfusion (WHO Grade 3 or 4).
PMOID: PMO:00000910
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.3
database_cross_reference: HPO:HP:0011888

Bleeding with minor or no trauma
type: Class
subclass of: Abnormal bleeding
definition: Significant bleeding or hemorrhage without significant precipitating factor.
PMOID: PMO:00000911
Subclass_of: Abnormal bleeding
Synonym: Easy bleeding
Tree Number: T3.2.1.4
database_cross_reference: HPO:HP:0011889

Prolonged bleeding following procedure
type: Class
subclass of: Abnormal bleeding
definition: Prolonged or protracted bleeding following an invasive procedure or intervention.
PMOID: PMO:00000918
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.11
database_cross_reference: HPO:HP:0011890

Abnormal hemoglobin
type: Class
subclass of: Abnormal erythrocyte morphology
definition: Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes.
PMOID: PMO:00000932
Subclass_of: Abnormal erythrocyte morphology
Synonym: ABNORM HEMOGLOBINS
Synonym: Abnormal Hemoglobins
Synonym: Abnormal haemoglobin
Synonym: Abnormal haemoglobin, NOS
Synonym: Abnormal hemoglobin (substance)
Synonym: Abnormal hemoglobin NOS
Synonym: Abnormal hemoglobin, NOS
Synonym: HEMOGLOBINS ABNORM
Synonym: Hemoglobin, abnormal
Synonym: Hemoglobins, Abnormal
Tree Number: T3.2.2.3
database_cross_reference: CHV:0000005996
database_cross_reference: HPO:HP:0011902
database_cross_reference: ICD10CM:D58.2
database_cross_reference: MSH:D006455
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:282.7
database_cross_reference: NDFRT:N0000170053
database_cross_reference: SNM:F-16600
database_cross_reference: SNM:U000192
database_cross_reference: SNMI:F-D5200
database_cross_reference: SNOMEDCT_US:8257005

Cardiovascular calcification
type: Class
subclass of: Abnormality of cardiovascular system morphology
definition: Abnormal calcification in the cardiovascular system.
PMOID: PMO:00004706
Subclass_of: Abnormality of cardiovascular system morphology
Tree Number: T3.9.2.2
database_cross_reference: HPO:HP:0011915

Abnormality of the pectoral muscle
type: Class
subclass of: Abnormality of the musculature of the thorax
definition: An abnormality of the pectoral muscle, comprising the pectoralis major, a thick, fan-shaped muscle of the anterior chest and the pectoralis minor, a thin, triangular muscle situated underneath the pectoralis major.
PMOID: PMO:00009740
Subclass_of: Abnormality of the musculature of the thorax
Synonym: Abnormal pec muscles
Tree Number: T3.17.11.1
database_cross_reference: HPO:HP:0011957

Cerebral amyloid angiopathy
type: Class
subclass of: Amyloidosis
definition: Amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system.
PMOID: PMO:00004243
Subclass_of: Amyloidosis
Synonym: Amyloid Angiopathy, Cerebral
Synonym: Angiopathy, Cerebral Amyloid
Synonym: Angiopathy, Congophilic
Synonym: CAA - Cerebral amyloid angiopathy
Synonym: CAA-Cerebr amyloid angiopath
Synonym: Cerebral Amyloid Angiopathies
Synonym: Cerebral Amyloid Angiopathy
Synonym: Cerebral Amyloid Angiopathy [Disease/Finding]
Synonym: Cerebral amyloid angiopathy (disorder)
Synonym: Congophilic Angiopathies
Tree Number: T3.6.24.3
database_cross_reference: CHV:0000015504
database_cross_reference: HPO:HP:0011970
database_cross_reference: ICD10:I68.0
database_cross_reference: ICD10AM:I68.0
database_cross_reference: ICD10CM:I68.0
database_cross_reference: MDR:10068044
database_cross_reference: MEDCIN:32182
database_cross_reference: MSH:D016657
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84625
database_cross_reference: NDFRT:N0000003453
database_cross_reference: OMIM:MTHU038754
database_cross_reference: RCD:X00Do
database_cross_reference: SNOMEDCT_US:195228000
database_cross_reference: SNOMEDCT_US:230724001

Persistent patent ductus venosus
type: Class
subclass of: Abnormality of the fetal cardiovascular system
definition: Persistence of blood flow through the ductus venosus for longer than the normal time after birth.
PMOID: PMO:00004968
Subclass_of: Abnormality of the fetal cardiovascular system
Tree Number: T3.9.4.6
database_cross_reference: HPO:HP:0012021

Congenital portosystemic venous shunt
type: Class
subclass of: Abnormality of the fetal cardiovascular system
definition: A congenital defect of the vasculature such that there is a shunt (by-pass) of blood directly from the portal vein to the vena cava (i.e., the blood from the portal vein is not filtered through the liver).
PMOID: PMO:00004965
Subclass_of: Abnormality of the fetal cardiovascular system
Synonym: PATENT DUCTUS VENOSUS
Synonym: PDV
Synonym: PORTOSYSTEMIC VENOUS SHUNT, CONGENITAL
Synonym: PSVS
Synonym: Patent Ductus Venosus
Synonym: Patent ductus venosus
Synonym: Patent ductus venosus (disorder)
Synonym: Portosystemic Venous Shunt, Congenital
Synonym: patent ductus venosus
Tree Number: T3.9.4.3
database_cross_reference: CHV:0000030979
database_cross_reference: HPO:HP:0012022
database_cross_reference: MSH:C562830
database_cross_reference: OMIM:601466
database_cross_reference: RCD:X77uw
database_cross_reference: SNOMEDCT_US:253330006

Abnormality of urine hormone level
type: Class
subclass of: Abnormality of the endocrine system
definition: An abnormal concentration of a hormone in the urine.
PMOID: PMO:00006357
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.11
database_cross_reference: HPO:HP:0012029

Laryngeal dystonia
type: Class
subclass of: Dysphonia
definition: A form of focal dystonia that affects the vocal cords, associated with involuntary contractions of the vocal cords causing interruptions of speech and affecting the voice quality and often leading to patterned, repeated breaks in speech.
PMOID: PMO:00014030
Subclass_of: Dysphonia
Synonym: Laryngeal dystonia (disorder)
Synonym: Spasmodic dysphonia
Tree Number: T3.22.4.1
database_cross_reference: HPO:HP:0012049
database_cross_reference: MDR:10067678
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU025383
database_cross_reference: SNOMEDCT_US:3331000119108

Glycopeptiduria
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: Increased excretion of glycopeptides in the urine. Glycopeptides are peptides with carbohydrate moieties covalently attached to the side chains of the amino acid residues.
PMOID: PMO:00003734
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: High urine glycopeptide levels
Tree Number: T3.6.10.12
database_cross_reference: HPO:HP:0012067

Abnormality of circulating catecholamine level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An abnormal catecholamine concentration in the blood.
PMOID: PMO:00006178
Subclass_of: Abnormality of circulating hormone level
Synonym: Catecholamine levels abnormal
Tree Number: T3.12.3.13
database_cross_reference: HPO:HP:0012099

Abnormal circulating creatinine level
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: An abnormal concentration of creatinine in the blood.
PMOID: PMO:00004142
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: Abnormal blood creatinine level
Synonym: Creatinine levels abnormal
Tree Number: T3.6.18.2
database_cross_reference: HPO:HP:0012100

Abnormality of the mitochondrion
type: Class
subclass of: Abnormal cellular physiology
definition: An anomaly of the mitochondrion, the membranous cytoplasmic organelle the interior of which is subdivided by cristae. The mitochondrion is a self replicating organelle that is the site of tissue respiration.
PMOID: PMO:00003502
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.9
database_cross_reference: HPO:HP:0012103

Abnormality of circulating glucocorticoid level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An abnormality of the concentration of a glucocorticoid in the blood.
PMOID: PMO:00006180
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.14
database_cross_reference: HPO:HP:0012111

Abnormal albumin level
type: Class
subclass of: Abnormality of circulating protein level
definition: Deviation from normal concentration of albumin in the blood.
PMOID: PMO:00003916
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.1
database_cross_reference: HPO:HP:0012116

Abnormality of bone marrow stromal cells
type: Class
subclass of: Abnormality of bone marrow cell morphology
PMOID: PMO:00001138
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.3
database_cross_reference: HPO:HP:0012129

Abnormal erythroid lineage cell morphology
type: Class
subclass of: Abnormal myeloid cell morphology
definition: An anomaly of erythroid lineage cells, that is, of the erythropoietic cells in the lineage leading to and including erythrocytes.
PMOID: PMO:00001036
Subclass_of: Abnormal myeloid cell morphology
Synonym: Abnormality of cells of the erythroid lineage
Tree Number: T3.2.4.1
database_cross_reference: HPO:HP:0012130

Abnormal number of erythroid precursors
type: Class
subclass of: Abnormal erythrocyte morphology
definition: A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.
PMOID: PMO:00000953
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.7
database_cross_reference: HPO:HP:0012131

Dysplastic erythropoesis
type: Class
subclass of: Abnormal erythrocyte morphology
PMOID: PMO:00001012
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.13
database_cross_reference: HPO:HP:0012134

Abnormal granulocytopoietic cell morphology
type: Class
subclass of: Abnormality of bone marrow cell morphology
definition: An anomaly of cells involved in the formation of a granulocytes, that is, of the granulocytopoietic cell.
PMOID: PMO:00001124
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.1

Abnormal megakaryocyte morphology
type: Class
subclass of: Abnormality of bone marrow cell morphology
definition: Any structural anomaly of megakaryocytes. Mature blood platelets are released from the cytoplasm of megakaryocytes, which are bone-marrow resident cells.
PMOID: PMO:00001130
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.2

Abnormality of multiple cell lineages in the bone marrow
type: Class
subclass of: Abnormality of bone marrow cell morphology
PMOID: PMO:00001139
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.4
database_cross_reference: HPO:HP:0012145

Increased erythrocyte protoporphyrin concentration
type: Class
subclass of: Abnormality of the heme biosynthetic pathway
definition: An increased concentration of protoporphyrins in erythrocytes.
PMOID: PMO:00004198
Subclass_of: Abnormality of the heme biosynthetic pathway
Tree Number: T3.6.22.2
database_cross_reference: HPO:HP:0012187

Hyperemesis gravidarum
type: Class
subclass of: Prenatal maternal abnormality
definition: Excessive vomiting in early pregnancy, leading to the loss of 5% or more of body weight.
PMOID: PMO:00004392
Subclass_of: Prenatal maternal abnormality
Synonym: Excess vomiting in pregnancy
Synonym: Excessive pregnancy vomiting
Synonym: Excessive vomiting in pregnancy
Synonym: Excessive vomiting in pregnancy (disorder)
Synonym: Gravidarum -hyperemesis
Synonym: HYPEREMESIS GRAVIDARUM
Synonym: Hyperemesis
Synonym: Hyperemesis Gravidarum
Synonym: Hyperemesis Gravidarum [Disease/Finding]
Synonym: Hyperemesis arising during pregnancy
Tree Number: T3.7.11.3
database_cross_reference: CCPSS:0051605
database_cross_reference: CHV:0000006410
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:9357
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000871
database_cross_reference: DXP:U002020
database_cross_reference: HPO:HP:0012188
database_cross_reference: ICD10:O21
database_cross_reference: ICD10AM:O21
database_cross_reference: ICD10CM:O21
database_cross_reference: ICD9CM:643
database_cross_reference: ICPC2P:W05004
database_cross_reference: MDR:10015592
database_cross_reference: MDR:10015609
database_cross_reference: MDR:10020614
database_cross_reference: MEDCIN:32392
database_cross_reference: MSH:D006939
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87084
database_cross_reference: NCI_NICHD:C87084
database_cross_reference: NDFRT:N0000001582
database_cross_reference: RCD:L13..
database_cross_reference: SNMI:D8-11510
database_cross_reference: SNOMEDCT_US:14094001
database_cross_reference: SNOMEDCT_US:156113005
database_cross_reference: SNOMEDCT_US:267308007

Increased urinary porphobilinogen
type: Class
subclass of: Abnormality of the heme biosynthetic pathway
definition: Increased concentration of porphobilinogen in the urine.
PMOID: PMO:00004199
Subclass_of: Abnormality of the heme biosynthetic pathway
Tree Number: T3.6.22.3
database_cross_reference: HPO:HP:0012217

Intramuscular hematoma
type: Class
subclass of: Abnormal muscle morphology
definition: Blood clot formed within muscle tissue following leakage of blood into the tissue.
PMOID: PMO:00009567
Subclass_of: Abnormal muscle morphology
Synonym: Intramuscular haematoma
Synonym: Intramuscular hemorrhage
Tree Number: T3.17.1.8
database_cross_reference: HPO:HP:0012233

Urocanic aciduria
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: An increased concentration of urocanic acid in the urine.
PMOID: PMO:00004164
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: High urine urocanic acid levels
Synonym: UROCANASE DEFICIENCY
Synonym: UROCD
Synonym: Urocanase deficiency
Synonym: Urocanate hydratase deficiency
Synonym: Urocanate hydratase deficiency (disorder)
Tree Number: T3.6.18.11
database_cross_reference: HPO:HP:0012237
database_cross_reference: MSH:C536479
database_cross_reference: OMIM:276880
database_cross_reference: OMIM:MTHU037990
database_cross_reference: RCD:X40S7
database_cross_reference: SNMI:D6-A3120
database_cross_reference: SNOMEDCT_US:60952007

Abnormal reproductive system morphology
type: Class
subclass of: Abnormality of the genital system
definition: A structural or developmental anomaly of any of the tissues involved in the genital system.
PMOID: PMO:00007485
Subclass_of: Abnormality of the genital system
Synonym: Abnormal genital system morphology
Tree Number: T3.14.1.1
database_cross_reference: HPO:HP:0012243

Abnormal respiratory system morphology
type: Class
subclass of: Abnormality of the respiratory system
definition: A structural anomaly of the respiratory system.
PMOID: PMO:00011355
Subclass_of: Abnormality of the respiratory system
Tree Number: T3.19.1
database_cross_reference: HPO:HP:0012252

Abnormal respiratory epithelium morphology
type: Class
subclass of: Abnormal respiratory system morphology
definition: Any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.
PMOID: PMO:00011475
Subclass_of: Abnormal respiratory system morphology
Tree Number: T3.19.1.3
database_cross_reference: HPO:HP:0012253

Abnormal respiratory motile cilium physiology
type: Class
subclass of: Functional respiratory abnormality
definition: Any functional anomaly of the respiratory motile cilia.
PMOID: PMO:00011603
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.7
database_cross_reference: HPO:HP:0012261

Hepatic amyloidosis
type: Class
subclass of: Amyloidosis
definition: A form of amyloidosis that affects the liver.
PMOID: PMO:00004247
Subclass_of: Amyloidosis
Synonym: Amyloidosis of liver
Synonym: Amyloidosis, hepatic
Synonym: Hepatic amyloidosis (disorder)
Synonym: amyloid infiltration of liver
Synonym: amyloid infiltration of liver (diagnosis)
Synonym: amyloidosis liver
Synonym: hepatic amyloidosis
Tree Number: T3.6.24.7
database_cross_reference: CHV:0000026218
database_cross_reference: HPO:HP:0012280
database_cross_reference: MDR:10075251
database_cross_reference: MEDCIN:312146
database_cross_reference: OMIM:MTHU024182
database_cross_reference: SNMI:D5-81840
database_cross_reference: SNOMEDCT_US:9551004
database_cross_reference: SNOMEDCT_VET:9551004

Abnormal hypothalamus physiology
type: Class
subclass of: Abnormality of the hypothalamus-pituitary axis
definition: An abnormal functionality of the hypothalamus.
PMOID: PMO:00006251
Subclass_of: Abnormality of the hypothalamus-pituitary axis
Tree Number: T3.12.6.1
database_cross_reference: HPO:HP:0012285

Neoplasm of head and neck
type: Class
subclass of: Neoplasm by anatomical site
definition: A tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx.
PMOID: PMO:00014197
Subclass_of: Neoplasm by anatomical site
Synonym: HEAD NECK NEOPL
Synonym: Head and Neck Neoplasm
Synonym: Head and Neck Neoplasm (Excluding Central Nervous System)
Synonym: Head and Neck Neoplasms
Synonym: Head and Neck Neoplasms [Disease/Finding]
Synonym: Head and Neck Tumor
Synonym: Head and neck tumor
Synonym: Head, Neck Neoplasms
Synonym: NEOPL HEAD NECK
Synonym: Neoplasm of Head and Neck
Tree Number: T3.25.1.2
database_cross_reference: AOD:0000023037
database_cross_reference: CHV:0000005815
database_cross_reference: CSP:2005-4325
database_cross_reference: DO:DOID:11934
database_cross_reference: HPO:HP:0012288
database_cross_reference: MSH:D006258
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3077
database_cross_reference: NCI:TCGA
database_cross_reference: NDFRT:N0000001416
database_cross_reference: RCD:X78eD
database_cross_reference: RCDAE:X78eD
database_cross_reference: SNOMEDCT_US:255055008

Cutaneous amyloidosis
type: Class
subclass of: Amyloidosis
definition: The presence of amyloid deposition in the superficial dermis.
PMOID: PMO:00004245
Subclass_of: Amyloidosis
Synonym: AD type amyloidosis
Synonym: AD type amyloidosis (disorder)
Synonym: Amyloid lichen
Synonym: Amyloidosis cutis
Synonym: Amyloidosis of dermis
Synonym: Amyloidosis of skin
Synonym: Amyloidosis of skin (disorder)
Synonym: Amyloidosis, Primary Cutaneous
Synonym: Cutaneous amyloidosis (disorder)
Synonym: Lichen amyloidosis
Tree Number: T3.6.24.5
database_cross_reference: CHV:0000026302
database_cross_reference: HPO:HP:0012309
database_cross_reference: ICD10:L99.0
database_cross_reference: ICD10AM:L99.0
database_cross_reference: MDR:10011659
database_cross_reference: MDR:10024427
database_cross_reference: MSH:C562642
database_cross_reference: RCD:M2y9.
database_cross_reference: SNM:M-55180
database_cross_reference: SNMI:D6-94640
database_cross_reference: SNOMEDCT_US:201337008
database_cross_reference: SNOMEDCT_US:281882003
database_cross_reference: SNOMEDCT_US:282834007
database_cross_reference: SNOMEDCT_US:61985005
database_cross_reference: SNOMEDCT_US:718105008

Fibrous tissue neoplasm
type: Class
subclass of: Neoplasm by histology
definition: Any neoplasm composed of fibrous tissue.
PMOID: PMO:00014316
Subclass_of: Neoplasm by histology
Synonym: FIBROSARCOMA
Synonym: FIBROSARCOMA, MALIGNANT
Synonym: Fibrocytic tumor
Synonym: Fibrosarcoma
Synonym: Fibrosarcoma (disorder)
Synonym: Fibrosarcoma (excluding infantile fibrosarcoma)
Synonym: Fibrosarcoma (morphologic abnormality)
Synonym: Fibrosarcoma - not infantile
Synonym: Fibrosarcoma NOS
Synonym: Fibrosarcoma [Disease/Finding]
Tree Number: T3.25.2.3
database_cross_reference: AOD:0000004531
database_cross_reference: CCPSS:0056525
database_cross_reference: CHV:0000005036
database_cross_reference: COSTAR:U000290
database_cross_reference: CSP:2000-6227
database_cross_reference: DO:DOID:3355
database_cross_reference: DXP:U000648
database_cross_reference: HPO:HP:0100244
database_cross_reference: ICD10AM:M8810/3
database_cross_reference: ICPC2P:L71017
database_cross_reference: MDR:10016632
database_cross_reference: MDR:10016634
database_cross_reference: MDR:10016637
database_cross_reference: MEDCIN:271507
database_cross_reference: MSH:D005354
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3043
database_cross_reference: NCI_CDISC:C3043
database_cross_reference: NCI_CTEP-SDC:10016637
database_cross_reference: NCI_NCI-GLOSS:CDR0000046403
database_cross_reference: NCI_NICHD:C3043
database_cross_reference: NDFRT:N0000001248
database_cross_reference: OMIM:MTHU016126
database_cross_reference: RCD:BBG1.
database_cross_reference: RCDSY:BBG1.
database_cross_reference: SNM:M-8810/3
database_cross_reference: SNMI:M-88103
database_cross_reference: SNOMEDCT_US:443250000
database_cross_reference: SNOMEDCT_US:53654007
database_cross_reference: SNOMEDCT_VET:309521000009107

Abnormal homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An anomaly in the processes involved in the maintenance of an internal equilibrium.
PMOID: PMO:00003591
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.5
database_cross_reference: HPO:HP:0012337

Abnormal energy expenditure
type: Class
subclass of: Abnormal homeostasis
definition: Any anomaly in the utilization of energy (calories).
PMOID: PMO:00003592
Subclass_of: Abnormal homeostasis
Tree Number: T3.6.5.1
database_cross_reference: HPO:HP:0012338

Abnormal glycosylation
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An anomaly of a glycosylation process, i.e., a process involved in the covalent attachment of a glycosyl residue to a substrate molecule.
PMOID: PMO:00003690
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.4
database_cross_reference: HPO:HP:0012345

Abnormal eye morphology
type: Class
subclass of: Abnormality of the eye
definition: A structural anomaly of the globe of the eye, or bulbus oculi.
PMOID: PMO:00006420
Subclass_of: Abnormality of the eye
Synonym: Abnormally shaped eye
Tree Number: T3.13.1
database_cross_reference: HPO:HP:0012372

Abnormal eye physiology
type: Class
subclass of: Abnormality of the eye
definition: A functional anomaly of the eye.
PMOID: PMO:00007002
Subclass_of: Abnormality of the eye
Tree Number: T3.13.2
database_cross_reference: HPO:HP:0012373

Fatigue
type: Class
subclass of: Constitutional symptom
definition: A subjective feeling of tiredness characterized by a lack of energy and motivation.
PMOID: PMO:00014056
Subclass_of: Constitutional symptom
Synonym: Energy decreased
Synonym: FATIGUE
Synonym: Fatigue (finding)
Synonym: Fatigue NOS
Synonym: Fatigue [Disease/Finding]
Synonym: Fatigue extreme
Synonym: Fatigued
Synonym: Feeling of total lack of energy
Synonym: Lack (of);energy
Synonym: Lack of Energy
Tree Number: T3.23.5
database_cross_reference: AOD:0000001768
database_cross_reference: AOD:0000021618
database_cross_reference: AOD:0000021621
database_cross_reference: BI:BI00028
database_cross_reference: CCPSS:1014729
database_cross_reference: CHV:0000004914
database_cross_reference: COSTAR:298
database_cross_reference: CSP:1385-2059
database_cross_reference: CST:ASTHENIA
database_cross_reference: DXP:U001451
database_cross_reference: HPO:HP:0012378
database_cross_reference: ICD10CM:R53.83
database_cross_reference: ICPC2P:A04001
database_cross_reference: ICPC2P:A04004
database_cross_reference: LCH:U001739
database_cross_reference: LCH_NW:sh85047465
database_cross_reference: LNC:LA7542-9
database_cross_reference: LNC:MTHU013358
database_cross_reference: MDR:10016256
database_cross_reference: MDR:10016257
database_cross_reference: MDR:10016356
database_cross_reference: MDR:10024862
database_cross_reference: MDR:10043889
database_cross_reference: MDR:10043890
database_cross_reference: MDR:10047871
database_cross_reference: MDR:10057841
database_cross_reference: MEDCIN:273174
database_cross_reference: MEDCIN:314400
database_cross_reference: MEDLINEPLUS:5324
database_cross_reference: MSH:D005221
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.79
database_cross_reference: NCI:C3036
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CDISC:C3036
database_cross_reference: NCI_CTCAE:E11098
database_cross_reference: NCI_FDA:1849
database_cross_reference: NCI_NCI-GLOSS:CDR0000321374
database_cross_reference: NCI_NICHD:C3036
database_cross_reference: NDFRT:N0000001216
database_cross_reference: OMIM:MTHU010062
database_cross_reference: PDQ:CDR0000041390
database_cross_reference: PSY:19400
database_cross_reference: PSY:53290
database_cross_reference: RCD:1682.
database_cross_reference: RCD:R0071
database_cross_reference: RCD:R0075
database_cross_reference: RCD:X76Ai
database_cross_reference: RCD:XM06o
database_cross_reference: RCD:Xa96S
database_cross_reference: RCDSY:R0071
database_cross_reference: RCDSY:R0075
database_cross_reference: SNM:F-01610
database_cross_reference: SNMI:F-01360
database_cross_reference: SNOMEDCT_US:139126000
database_cross_reference: SNOMEDCT_US:158169005
database_cross_reference: SNOMEDCT_US:206767001
database_cross_reference: SNOMEDCT_US:206771003
database_cross_reference: SNOMEDCT_US:248274002
database_cross_reference: SNOMEDCT_US:302758002
database_cross_reference: SNOMEDCT_US:367392001
database_cross_reference: SNOMEDCT_US:84229001

Abnormal enzyme/coenzyme activity
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An altered ability of any enzyme or their cofactors to act as catalysts. This term includes changes due to altered levels of an enzyme.
PMOID: PMO:00003536
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.3
database_cross_reference: HPO:HP:0012379

Reduced carnitine O-palmitoyltransferase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: Reduced carnitine O-palmitoyltransferase activity, i.e., reduced activity of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.
PMOID: PMO:00003585
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.14
database_cross_reference: HPO:HP:0012380

Abnormal aldolase level
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: An abnormal concentration of aldolase in the serum. Aldolase is an enzyme responsible for converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate.
PMOID: PMO:00003537
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.1
database_cross_reference: HPO:HP:0012400

Abnormal blood gas level
type: Class
subclass of: Functional respiratory abnormality
definition: An abnormality of the partial pressure of oxygen or carbon dioxide in the arterial blood.
PMOID: PMO:00011553
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.1
database_cross_reference: HPO:HP:0012415

Meconium stained amniotic fluid
type: Class
subclass of: Abnormality of the amniotic fluid
definition: Amniotic fluid containing the earliest stools of a mammalian infant.
PMOID: PMO:00004348
Subclass_of: Abnormality of the amniotic fluid
Synonym: Meconium staining of amniotic fluid
Synonym: Meconium-stained amniotic fluid
Tree Number: T3.7.3.2
database_cross_reference: HPO:HP:0012420

Episodic fatigue
type: Class
subclass of: Fatigue
definition: Intermittent and recurrent bouts of a subjective feeling of tiredness characterized by a lack of energy and motivation.
PMOID: PMO:00014058
Subclass_of: Fatigue
Tree Number: T3.23.5.2
database_cross_reference: HPO:HP:0012431

Chronic fatigue
type: Class
subclass of: Fatigue
definition: Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer.
PMOID: PMO:00014057
Subclass_of: Fatigue
Synonym: Chronic extreme exhaustion
Tree Number: T3.23.5.1
database_cross_reference: HPO:HP:0012432

Abnormal myelination
type: Class
subclass of: Abnormality of nervous system morphology
definition: Any anomaly in the process by which myelin sheaths are formed and maintained around neurons.
PMOID: PMO:00009765
Subclass_of: Abnormality of nervous system morphology
Tree Number: T3.18.2.1
database_cross_reference: HPO:HP:0012447

Nuchal cord
type: Class
subclass of: Abnormal delivery
definition: A complication of pregnancy and delivery in which the umbilical cord wraps around the fetal neck once or multiple times.
PMOID: PMO:00004304
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.6
database_cross_reference: HPO:HP:0012498

Reduced thyroxin-binding globulin
type: Class
subclass of: Abnormality of circulating protein level
definition: An abnormally decreased amount of thyroxin-binding globulin (TBG) in blood. TBG is responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream.
PMOID: PMO:00003973
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.26
database_cross_reference: HPO:HP:0012509

Reduced catalase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: An abnormally decreased amount of catalase activity.
PMOID: PMO:00003586
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.15
database_cross_reference: HPO:HP:0012517

Pain
type: Class
subclass of: Constitutional symptom
definition: An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
PMOID: PMO:00014074
Subclass_of: Constitutional symptom
Synonym: A26-A29 TYPES OF PAIN
Synonym: Dolor
Synonym: PAIN
Synonym: Pain (finding)
Synonym: Pain NOS
Synonym: Pain [Disease/Finding]
Synonym: Pain finding
Synonym: Pain finding (finding)
Synonym: Pain observations
Synonym: Pain symptoms
Tree Number: T3.23.10
database_cross_reference: AOD:0000002779
database_cross_reference: AOD:0000002780
database_cross_reference: BI:BI00754
database_cross_reference: CCPSS:0035760
database_cross_reference: CHV:0000009185
database_cross_reference: COSTAR:548
database_cross_reference: CSP:2683-4824
database_cross_reference: CST:PAIN
database_cross_reference: HPO:HP:0012531
database_cross_reference: ICD10:R52.9
database_cross_reference: ICD10AM:R52.9
database_cross_reference: ICD10CM:R52
database_cross_reference: ICD9CM:338-338.99
database_cross_reference: ICPC2P:A01002
database_cross_reference: ICPC2P:A29020
database_cross_reference: LCH:U003436
database_cross_reference: LCH_NW:sh85096617
database_cross_reference: LNC:LA17107-6
database_cross_reference: LNC:LA7460-4
database_cross_reference: LNC:MTHU021175
database_cross_reference: LNC:MTHU029813
database_cross_reference: MDR:10033371
database_cross_reference: MDR:10033470
database_cross_reference: MEDCIN:283263
database_cross_reference: MEDCIN:314434
database_cross_reference: MEDLINEPLUS:351
database_cross_reference: MSH:D010146
database_cross_reference: MTH:306
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.96
database_cross_reference: NCI:C25271
database_cross_reference: NCI:C3303
database_cross_reference: NCI:ESAS
database_cross_reference: NCI:LASA
database_cross_reference: NCI_CTCAE:E11167
database_cross_reference: NCI_FDA:1994
database_cross_reference: NCI_NICHD:C3303
database_cross_reference: NDFRT:N0000002278
database_cross_reference: OMIM:MTHU033713
database_cross_reference: PDQ:CDR0000041399
database_cross_reference: PSY:36150
database_cross_reference: RCD:Xa07F
database_cross_reference: RCD:Xa0yP
database_cross_reference: SNM:F-82600
database_cross_reference: SNMI:F-A2600
database_cross_reference: SNOMEDCT_US:162412006
database_cross_reference: SNOMEDCT_US:22253000
database_cross_reference: SNOMEDCT_US:279075009
database_cross_reference: SNOMEDCT_US:366981002
database_cross_reference: SNOMEDCT_US:367206007

Chronic pain
type: Class
subclass of: Pain
definition: Persistent pain, usually defined as pain that has laster longer than 3 to 6 months.
PMOID: PMO:00014088
Subclass_of: Pain
Synonym: Chronic Pain
Synonym: Chronic Pain [Disease/Finding]
Synonym: Chronic Pains
Synonym: Chronic pain (finding)
Synonym: PAIN CHRONIC
Synonym: Pain, Chronic
Synonym: Pain;chronic
Synonym: Pains, Chronic
Synonym: chronic pain
Synonym: chronic pain (diagnosis)
Tree Number: T3.23.10.9
database_cross_reference: CCPSS:1002509
database_cross_reference: CHV:0000016768
database_cross_reference: CSP:4008-0027
database_cross_reference: HPO:HP:0012532
database_cross_reference: ICD9CM:338.2
database_cross_reference: ICPC2P:A01005
database_cross_reference: LCH_NW:sh93009482
database_cross_reference: LNC:MTHU013382
database_cross_reference: MDR:10049475
database_cross_reference: MEDCIN:311901
database_cross_reference: MEDCIN:314433
database_cross_reference: MEDLINEPLUS:5995
database_cross_reference: MSH:D059350
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26940
database_cross_reference: NCI_NCI-GLOSS:CDR0000044654
database_cross_reference: NCI_NICHD:C26940
database_cross_reference: NDFRT:N0000183371
database_cross_reference: OMIM:MTHU036441
database_cross_reference: PSY:09185
database_cross_reference: SNMI:F-A2950
database_cross_reference: SNOMEDCT_US:82423001

Allodynia
type: Class
subclass of: Pain
definition: Pain due to a stimulus that does not normally provoke pain.
PMOID: PMO:00014078
Subclass_of: Pain
Synonym: HYPERALGESIA
Synonym: HYPERALGIA
Synonym: Hyperalgesia
Synonym: Hyperalgesia (finding)
Synonym: Hyperalgesia [Disease/Finding]
Synonym: Hyperalgesias
Synonym: Hyperalgesic Sensations
Synonym: Hyperalgia
Synonym: Hyperpathia
Synonym: Hyperpathia (finding)
Tree Number: T3.23.10.2
database_cross_reference: CCPSS:0048940
database_cross_reference: CHV:0000006400
database_cross_reference: CSP:4003-0026
database_cross_reference: CST:HYPERALGESIA
database_cross_reference: HPO:HP:0012533
database_cross_reference: HPO:HP:0031005
database_cross_reference: LCH_NW:sh92000586
database_cross_reference: MDR:10020573
database_cross_reference: MDR:10065952
database_cross_reference: MSH:D006930
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34703
database_cross_reference: NCI_NICHD:C34703
database_cross_reference: NDFRT:N0000001574
database_cross_reference: OMIM:MTHU044601
database_cross_reference: PSY:23741
database_cross_reference: RCD:X75t9
database_cross_reference: RCD:Xa0yS
database_cross_reference: SNM:F-82630
database_cross_reference: SNMI:F-A2630
database_cross_reference: SNOMEDCT_US:140908006
database_cross_reference: SNOMEDCT_US:163706006
database_cross_reference: SNOMEDCT_US:279078006
database_cross_reference: SNOMEDCT_US:55406008

Abnormal synaptic transmission
type: Class
subclass of: Abnormality of nervous system physiology
definition: An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process.
PMOID: PMO:00010683
Subclass_of: Abnormality of nervous system physiology
Synonym: Abnormality of neurotransmitter metabolism
Tree Number: T3.18.3.5
database_cross_reference: HPO:HP:0012535

Food intolerance
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.
PMOID: PMO:00004252
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Food intolerance (disorder)
Synonym: Malabsorption due to food intolerance
Synonym: Non-allergic food hypersensitivity
Synonym: malabsorption syndrome due to intolerance
Synonym: malabsorption syndrome due to intolerance (diagnosis)
Tree Number: T3.6.27
database_cross_reference: HPO:HP:0012537
database_cross_reference: MDR:10061958
database_cross_reference: MEDCIN:319169
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X3039
database_cross_reference: SNOMEDCT_US:235719002

Cephalohematoma
type: Class
subclass of: Abnormal bleeding
definition: Hemorrhage between the skull and periosteum of a newborn resulting from rupture of blood vessels that cross the periosteum.
PMOID: PMO:00000912
Subclass_of: Abnormal bleeding
Synonym: Cephalohaematoma
Tree Number: T3.2.1.5
database_cross_reference: HPO:HP:0012541

Skewed maternal X inactivation
type: Class
subclass of: Prenatal maternal abnormality
definition: A deviation from equal (50%) inactivation of each parental X chromosome in maternal cells.
PMOID: PMO:00004405
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.12
database_cross_reference: HPO:HP:0012546

Fatty replacement of skeletal muscle
type: Class
subclass of: Abnormal muscle morphology
definition: Muscle fibers degeneration resulting in fatty replacement of skeletal muscle fibers
PMOID: PMO:00009564
Subclass_of: Abnormal muscle morphology
Synonym: Skeletal muscle fatty infiltration
Tree Number: T3.17.1.5
database_cross_reference: HPO:HP:0012548

Abnormal intraocular pressure
type: Class
subclass of: Abnormal eye physiology
definition: An anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye.
PMOID: PMO:00007038
Subclass_of: Abnormal eye physiology
Synonym: Abnormal eye pressure
Tree Number: T3.13.2.2
database_cross_reference: HPO:HP:0012632

Abnormality of nervous system physiology
type: Class
subclass of: Abnormality of the nervous system
definition: A functional anomaly of the nervous system.
PMOID: PMO:00010546
Subclass_of: Abnormality of the nervous system
Tree Number: T3.18.3
database_cross_reference: HPO:HP:0012638

Abnormality of nervous system morphology
type: Class
subclass of: Abnormality of the nervous system
definition: A structural anomaly of the nervous system.
PMOID: PMO:00009764
Subclass_of: Abnormality of the nervous system
Synonym: Abnormal shape of nervous system
Tree Number: T3.18.2
database_cross_reference: HPO:HP:0012639

Abnormality of intracranial pressure
type: Class
subclass of: Abnormality of nervous system physiology
definition: A deviation from the norm of the intracranial pressure.
PMOID: PMO:00010869
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.9
database_cross_reference: HPO:HP:0012640

Abnormal inflammatory response
type: Class
subclass of: Abnormality of immune system physiology
definition: Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
PMOID: PMO:00008379
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.1
database_cross_reference: HPO:HP:0012647

Abnormal brain positron emission tomography
type: Class
subclass of: Abnormality of nervous system physiology
definition: A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain.
PMOID: PMO:00010547
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.1
database_cross_reference: HPO:HP:0012657

Abnormality of the pineal gland
type: Class
subclass of: Abnormality of the endocrine system
definition: An anomaly of the pineal gland,a small endocrine gland in the brain that produces melatonin.
PMOID: PMO:00006271
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.8
database_cross_reference: HPO:HP:0012680

Abnormality of pineal morphology
type: Class
subclass of: Abnormality of the pineal gland
definition: A structural abnormality of the pineal gland.
PMOID: PMO:00006272
Subclass_of: Abnormality of the pineal gland
Tree Number: T3.12.8.1
database_cross_reference: HPO:HP:0012681

Abnormality of pineal physiology
type: Class
subclass of: Abnormality of the pineal gland
definition: A functional abnormality of the pineal gland.
PMOID: PMO:00006278
Subclass_of: Abnormality of the pineal gland
Tree Number: T3.12.8.2
database_cross_reference: HPO:HP:0012688

Abnormal large intestine physiology
type: Class
subclass of: Abnormality of digestive system physiology
definition: A functional anomaly of the large intestine.
PMOID: PMO:00005357
Subclass_of: Abnormality of digestive system physiology
Tree Number: T3.10.3.2
database_cross_reference: HPO:HP:0012700

Abnormal metabolic brain imaging by MRS
type: Class
subclass of: Abnormality of nervous system physiology
definition: An anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS).
PMOID: PMO:00010560
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.3
database_cross_reference: HPO:HP:0012705

Morphological abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
definition: Abnormal structure of the gastrointestinal tract.
PMOID: PMO:00005595
Subclass_of: Abnormality of the gastrointestinal tract
Synonym: Abnormal shape of the digestive system
Synonym: Morphological anomaly of the digestive system
Tree Number: T3.10.6.2
database_cross_reference: HPO:HP:0012718

Functional abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
definition: Abnormal functionality of the gastrointestinal tract.
PMOID: PMO:00005562
Subclass_of: Abnormality of the gastrointestinal tract
Tree Number: T3.10.6.1
database_cross_reference: HPO:HP:0012719

Cough
type: Class
subclass of: Functional respiratory abnormality
definition: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
PMOID: PMO:00011631
Subclass_of: Functional respiratory abnormality
Synonym: 241 COUGHS
Synonym: C/O - cough
Synonym: C/O - cough (context-dependent category)
Synonym: COUGH
Synonym: COUGHING
Synonym: COUGHS
Synonym: Complaining of cough
Synonym: Complaining of cough (finding)
Synonym: Cough (finding)
Synonym: Cough [Disease/Finding]
Tree Number: T3.19.2.14
database_cross_reference: AOD:0000000620
database_cross_reference: BI:BI00179
database_cross_reference: CCPSS:1017295
database_cross_reference: CHV:0000003404
database_cross_reference: CHV:0000033491
database_cross_reference: COSTAR:212
database_cross_reference: CSP:2616-8354
database_cross_reference: CST:COUGH INC
database_cross_reference: DRUGBANK:DB00316
database_cross_reference: DRUGBANK:DB00366
database_cross_reference: DRUGBANK:DB00514
database_cross_reference: DRUGBANK:DB00874
database_cross_reference: DXP:U000880
database_cross_reference: HPO:HP:0012735
database_cross_reference: ICD10:R05
database_cross_reference: ICD10AM:R05
database_cross_reference: ICD10CM:R05
database_cross_reference: ICD9CM:786.2
database_cross_reference: ICPC2EENG:R05
database_cross_reference: ICPC2P:R05004
database_cross_reference: LCH:U001180
database_cross_reference: LCH_NW:sh85033394
database_cross_reference: MDR:10011224
database_cross_reference: MDR:10011232
database_cross_reference: MEDCIN:247
database_cross_reference: MEDLINEPLUS:1543
database_cross_reference: MSH:D003371
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C37935
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_CTCAE:E13364
database_cross_reference: NCI_NICHD:C37935
database_cross_reference: NDFRT:N0000000863
database_cross_reference: OMIM:MTHU015709
database_cross_reference: RCD:171Z.
database_cross_reference: RCD:R062.
database_cross_reference: RCD:XC07I
database_cross_reference: RCD:XE0qn
database_cross_reference: RCD:XM0Ch
database_cross_reference: RCD:Xa7u8
database_cross_reference: RCDSY:R062.
database_cross_reference: SNM:F-75860
database_cross_reference: SNMI:F-24100
database_cross_reference: SNOMEDCT_US:139176003
database_cross_reference: SNOMEDCT_US:139190000
database_cross_reference: SNOMEDCT_US:158383001
database_cross_reference: SNOMEDCT_US:161921002
database_cross_reference: SNOMEDCT_US:161935000
database_cross_reference: SNOMEDCT_US:207066005
database_cross_reference: SNOMEDCT_US:263731006
database_cross_reference: SNOMEDCT_US:272039006
database_cross_reference: SNOMEDCT_US:301235001
database_cross_reference: SNOMEDCT_US:49727002
database_cross_reference: SNOMEDCT_VET:49727002

Abnormal neuron morphology
type: Class
subclass of: Abnormality of nervous system morphology
definition: A structural anomaly of a neuron.
PMOID: PMO:00009794
Subclass_of: Abnormality of nervous system morphology
Synonym: Abnormal neuron shape
Tree Number: T3.18.2.2
database_cross_reference: HPO:HP:0012757

Neurodevelopmental abnormality
type: Class
subclass of: Abnormality of nervous system physiology
definition: A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities.
PMOID: PMO:00011224
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.20
database_cross_reference: HPO:HP:0012759

Abnormal arm span
type: Class
subclass of: Abnormality of the upper limb
definition: A deviation from normal of the length of the arm span (length from one end of an individual's arms (measured at the fingertips) to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle.
PMOID: PMO:00002861
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.1
database_cross_reference: HPO:HP:0012769

Abnormal upper to lower segment ratio
type: Class
subclass of: Abnormality of body height
definition: A deviation from normal of the relation between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis.
PMOID: PMO:00014117
Subclass_of: Abnormality of body height
Tree Number: T3.24.1.1
database_cross_reference: HPO:HP:0012772

Neoplasm of the ear
type: Class
subclass of: Abnormal ear morphology
definition: A tumor (abnormal growth of tissue) of the ear.
PMOID: PMO:00006063
Subclass_of: Abnormal ear morphology
Synonym: EAR NEOPL
Synonym: Ear Neoplasm
Synonym: Ear Neoplasms
Synonym: Ear Neoplasms [Disease/Finding]
Synonym: Ear Tumor
Synonym: Ear neoplasm
Synonym: Ear tumor
Synonym: Ear--Tumors
Synonym: NEOPL EAR
Synonym: Neoplasm of Ear
Tree Number: T3.11.1.5
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2018-3094
database_cross_reference: DO:DOID:833
database_cross_reference: HPO:HP:0012780
database_cross_reference: ICPC2EENG:H75
database_cross_reference: ICPC2P:H75006
database_cross_reference: LCH_NW:sh85040394
database_cross_reference: MDR:10055016
database_cross_reference: MEDCIN:354965
database_cross_reference: MSH:D004428
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3000
database_cross_reference: NDFRT:N0000001037
database_cross_reference: SNOMEDCT_US:363228008

Skin appendage neoplasm
type: Class
subclass of: Abnormality of skin adnexa morphology
definition: A benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands.
PMOID: PMO:00008931
Subclass_of: Abnormality of skin adnexa morphology
Synonym: Adnexal Neoplasm of skin
Synonym: Adnexal Neoplasm of the skin
Synonym: Adnexal Tumor of skin
Synonym: Adnexal Tumor of the skin
Synonym: Adnexal and skin appendage neoplasm (morphologic abnormality)
Synonym: Adnexal and skin appendage neoplasm NOS (morphologic abnormality)
Synonym: Adnexal and skin appendage tumor (qualifier value)
Synonym: Cutaneous Adnexal Neoplasm
Synonym: Epidermal Appendage Neoplasm
Synonym: Epidermal Appendage Tumor
Tree Number: T3.16.1.4
database_cross_reference: DO:DOID:2433
database_cross_reference: DO:DOID:3899
database_cross_reference: HPO:HP:0012842
database_cross_reference: MDR:10045153
database_cross_reference: MEDCIN:355117
database_cross_reference: NCI:C4463
database_cross_reference: RCD:X78Rm
database_cross_reference: RCD:XM1FH
database_cross_reference: RCDAE:X78Rm
database_cross_reference: RCDAE:XM1FH
database_cross_reference: SNM:M-8390/0
database_cross_reference: SNMI:M-83900
database_cross_reference: SNOMEDCT_US:126489007
database_cross_reference: SNOMEDCT_US:55681005

Neck muscle hypertrophy
type: Class
subclass of: Abnormality of the musculature of the neck
definition: Muscle hypertrophy affecting the muscles of the neck.
PMOID: PMO:00009729
Subclass_of: Abnormality of the musculature of the neck
Synonym: Hypertrophy of cervical muscles
Synonym: Large neck muscles
Synonym: Overgrowth of neck muscles
Tree Number: T3.17.9.4
database_cross_reference: HPO:HP:0012893

Abnormal myeloid cell morphology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: Any structural anomaly of a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
PMOID: PMO:00001035
Subclass_of: Abnormality of blood and blood-forming tissues
Tree Number: T3.2.4
database_cross_reference: HPO:HP:0020047

Reduced bone-marrow pro-B cell count
type: Class
subclass of: Abnormality of bone marrow cell morphology
definition: A reduction in the numbers of pro-B cells (defined by coexpression of CD34 and CD19). Earlier B-cell precursors are defined by expressing surface CD34 and cytoplasmic TdT in the absence of CD19.
PMOID: PMO:00001146
Subclass_of: Abnormality of bone marrow cell morphology
Tree Number: T3.2.7.5
database_cross_reference: HPO:HP:0020048

Abnormal erythrocyte physiology
type: Class
subclass of: Abnormality of blood and blood-forming tissues
definition: Any functional abnormality of erythrocytes (red-blood cells).
PMOID: PMO:00001031
Subclass_of: Abnormality of blood and blood-forming tissues
Tree Number: T3.2.3
database_cross_reference: HPO:HP:0020054

Abnormal red blood cell count
type: Class
subclass of: Abnormal erythrocyte morphology
definition: Any deviation from the normal number of red blood cells per volume in the circulation.
PMOID: PMO:00000958
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.8
database_cross_reference: HPO:HP:0020058

Abnormal hemoglobin concentration
type: Class
subclass of: Abnormal erythrocyte morphology
definition: Any deviation from the normal concentration of hemoglobin in the blood.
PMOID: PMO:00000944
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.4
database_cross_reference: HPO:HP:0020061

Tracheal tug on inspiration
type: Class
subclass of: Functional respiratory abnormality
definition: Downward movement of the trachea during inspiration due to downward traction on the tracheobronchial tree.
PMOID: PMO:00011667
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.23
database_cross_reference: HPO:HP:0025008

Abnormal vascular morphology
type: Class
subclass of: Abnormality of the vasculature
PMOID: PMO:00004971
Subclass_of: Abnormality of the vasculature
Tree Number: T3.9.5.1
database_cross_reference: HPO:HP:0025015

Elevated prostate-specific antigen level
type: Class
subclass of: Abnormality of circulating protein level
definition: An increased concentration of prostate specific antigen (PSA) in the circulation.
PMOID: PMO:00003963
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.17
database_cross_reference: HPO:HP:0025020

Abnormal erythrocyte sedimentation rate
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: A deviation from normal range of the erythrocyte sedimentation rate (ESR), a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.
PMOID: PMO:00003588
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Abnormal ESR
Synonym: Abnormal Westergren sedimentation rate
Tree Number: T3.6.4
database_cross_reference: HPO:HP:0025021

Decreased erythrocyte sedimentation rate
type: Class
subclass of: Abnormal erythrocyte sedimentation rate
definition: A reduced erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.
PMOID: PMO:00003589
Subclass_of: Abnormal erythrocyte sedimentation rate
Synonym: Low ESR
Tree Number: T3.6.4.1
database_cross_reference: HPO:HP:0025022

Abnormality of the digestive system
type: Class
subclass of: Phenotypic Abnormality
PMOID: PMO:00005299
Subclass_of: Phenotypic Abnormality
Synonym: 4-50 CONGENITAL ANOMALIES OF THE DIGESTIVE SYSTEM: GENERAL TERMS
Synonym: ABNORM DIGESTIVE SYSTEM
Synonym: Abnormalities, Digestive System
Synonym: Abnormality, Digestive System
Synonym: Anom digestive syst NOS
Synonym: CONGENITAL ANOMALIES OF THE DIGESTIVE SYSTEM
Synonym: CONGENITAL ANOMALIES OF THE DIGESTIVE SYSTEM: GENERAL TERMS
Synonym: Congen malform digestive syst
Synonym: Congenital anomaly NOS of digestive system NOS
Synonym: Congenital anomaly digestive system
Tree Number: T3.10
database_cross_reference: CHV:0000003938
database_cross_reference: CHV:0000025980
database_cross_reference: HPO:HP:0025031
database_cross_reference: ICD10:Q45.9
database_cross_reference: ICD10AM:Q45.9
database_cross_reference: ICD10CM:Q45.9
database_cross_reference: ICD9CM:751.9
database_cross_reference: ICPC2EENG:D81
database_cross_reference: ICPC2P:D81006
database_cross_reference: MDR:10045697
database_cross_reference: MEDCIN:211250
database_cross_reference: MSH:D004065
database_cross_reference: MTH:U000145
database_cross_reference: MTHICD9:751.9
database_cross_reference: NDFRT:N0000000972
database_cross_reference: RCD:PBz..
database_cross_reference: RCD:Xa9Cy
database_cross_reference: SNMI:D4-50000
database_cross_reference: SNOMEDCT_US:204820005
database_cross_reference: SNOMEDCT_US:69518005

Abnormality of digestive system physiology
type: Class
subclass of: Abnormality of the digestive system
definition: A functional anomaly of the digestive system.
PMOID: PMO:00005318
Subclass_of: Abnormality of the digestive system
Tree Number: T3.10.3
database_cross_reference: HPO:HP:0025032

Abnormality of digestive system morphology
type: Class
subclass of: Abnormality of the digestive system
definition: A structural anomaly of the digestive system.
PMOID: PMO:00005313
Subclass_of: Abnormality of the digestive system
Tree Number: T3.10.2
database_cross_reference: HPO:HP:0025033

Abnormal mean corpuscular volume
type: Class
subclass of: Abnormal erythrocyte morphology
definition: A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.
PMOID: PMO:00000950
Subclass_of: Abnormal erythrocyte morphology
Synonym: Abnormal MCV
Synonym: Abnormal erythrocyte volume
Tree Number: T3.2.2.6
database_cross_reference: HPO:HP:0025065

Sneeze
type: Class
subclass of: Functional respiratory abnormality
definition: A sudden violent, spasmodic, audible expiration of breath through the nose and mouth.
PMOID: PMO:00011665
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.22
database_cross_reference: HPO:HP:0025095

Fetal distress
type: Class
subclass of: Abnormality of prenatal development or birth
definition: An intrauterine state characterized by suboptimal values in the fetal heart rate, oxygenation of fetal blood, or other parameters indicative of compromise of the fetus. Signs of fetal distress include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile.
PMOID: PMO:00004352
Subclass_of: Abnormality of prenatal development or birth
Synonym: Distress - fetal
Synonym: Distress, Fetal
Synonym: FETAL DISTRESS
Synonym: FOETAL DISTRESS
Synonym: Fetal Distress
Synonym: Fetal Distress [Disease/Finding]
Synonym: Fetal Intolerance of Labor
Synonym: Fetal Status, Nonreassuring
Synonym: Fetal distress (finding)
Synonym: Fetal distress NOS
Tree Number: T3.7.5
database_cross_reference: AOD:0000004920
database_cross_reference: CCPSS:1008189
database_cross_reference: CHV:0000004991
database_cross_reference: CST:FETAL DIS
database_cross_reference: CST:PERINATAL DIS
database_cross_reference: DO:DOID:4027
database_cross_reference: DXP:U001470
database_cross_reference: HPO:HP:0025116
database_cross_reference: LCH:U001772
database_cross_reference: LCH_NW:sh85047945
database_cross_reference: MDR:10016486
database_cross_reference: MDR:10016492
database_cross_reference: MDR:10016854
database_cross_reference: MDR:10016855
database_cross_reference: MDR:10042806
database_cross_reference: MDR:10055709
database_cross_reference: MSH:D005316
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C50563
database_cross_reference: NCI_FDA:1856
database_cross_reference: NCI_NICHD:C50563
database_cross_reference: NDFRT:N0000001234
database_cross_reference: OMIM:MTHU009786
database_cross_reference: RCD:L2630
database_cross_reference: RCD:L263z
database_cross_reference: RCD:Xa0kg
database_cross_reference: SNM:F-33020
database_cross_reference: SNOMEDCT_US:130955003
database_cross_reference: SNOMEDCT_US:157098009
database_cross_reference: SNOMEDCT_US:157103006
database_cross_reference: SNOMEDCT_US:199591006
database_cross_reference: SNOMEDCT_US:199604002
database_cross_reference: SNOMEDCT_US:267336002
database_cross_reference: SNOMEDCT_US:268873007

Decreased small intestinal mucosa lactase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: Lactase is produced in the small intestine in humans, Lactase is a member of the beta-galactosidase family of enzymes, and hydrolyzes D-lactose to form D-galactose and D-glucose, which can be absorbed by the small intestine. There are many ways of assessing lactase activity. In one test, an endoscopic biopsy from the postbulbar duodenum is incubated with lactose on a test plate, and a color reaction develops within 20 min as a result of hydrolyzed lactose (a positive result) in patients with normolactasia, whereas no reaction (a negative result) develops in patients with severe hypolactasia. Other, less direct, tests include the hydrogen breath test, and blood tests following lactose challenges.
PMOID: PMO:00003582
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Lactase deficiency
Tree Number: T3.6.3.11
database_cross_reference: HPO:HP:0025130

Abnormal circulating estrogen level
type: Class
subclass of: Abnormality of circulating hormone level
definition: A deviation from normal concentration of the hormone estrogen in the blood circulation.
PMOID: PMO:00006141
Subclass_of: Abnormality of circulating hormone level
Synonym: Abnormal circulating oestrogen level
Synonym: Abnormal estrogen level
Tree Number: T3.12.3.4
database_cross_reference: HPO:HP:0025132

Gingival calcification
type: Class
subclass of: Ectopic calcification
definition: Ectopic deposition of calcium salts found in the gingiva.
PMOID: PMO:00014009
Subclass_of: Ectopic calcification
Synonym: Gingival calcifications
Tree Number: T3.20.4.5
database_cross_reference: HPO:HP:0025141

Constitutional symptom
type: Class
subclass of: Phenotypic Abnormality
definition: A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.
PMOID: PMO:00014047
Subclass_of: Phenotypic Abnormality
Synonym: CONSTITUTIONAL SYMPTOM
Synonym: CONSTITUTIONAL SYMPTOMS
Synonym: Constitutional Finding
Synonym: Constitutional Symptom
Synonym: Constitutional symptoms
Tree Number: T3.23
database_cross_reference: CCPSS:0032130
database_cross_reference: COSTAR:201
database_cross_reference: HPO:HP:0025142
database_cross_reference: LNC:LP96320-4
database_cross_reference: LNC:MTHU034799
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38469

Chills
type: Class
subclass of: Constitutional symptom
definition: A sudden sensation of feeling cold.
PMOID: PMO:00014054
Subclass_of: Constitutional symptom
Synonym: CHILL
Synonym: CHILLS
Synonym: Chill
Synonym: Chill (finding)
Synonym: Chill(s) NOS
Synonym: Chills NOS
Synonym: Chills [Disease/Finding]
Synonym: [D]Chill(s) NOS
Synonym: [D]Chill(s) NOS (context-dependent category)
Synonym: [D]Chill(s) NOS (situation)
Tree Number: T3.23.4
database_cross_reference: AOD:0000004397
database_cross_reference: CCPSS:1000736
database_cross_reference: CHV:0000015674
database_cross_reference: COSTAR:U000129
database_cross_reference: CST:CHILLS
database_cross_reference: DXP:U000732
database_cross_reference: HPO:HP:0025143
database_cross_reference: ICD10CM:R68.83
database_cross_reference: ICPC2EENG:A02
database_cross_reference: ICPC2P:A02001
database_cross_reference: LNC:MTHU013512
database_cross_reference: MDR:10008531
database_cross_reference: MEDCIN:7
database_cross_reference: MSH:D023341
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.64
database_cross_reference: NCI:C35143
database_cross_reference: NCI_CTCAE:E11074
database_cross_reference: NCI_FDA:2191
database_cross_reference: NCI_NICHD:C35143
database_cross_reference: NDFRT:N0000004252
database_cross_reference: RCD:R00z1
database_cross_reference: RCD:X76Dn
database_cross_reference: RCDSY:R00z1
database_cross_reference: SNM:F-03260
database_cross_reference: SNMI:F-03260
database_cross_reference: SNOMEDCT_US:158179007
database_cross_reference: SNOMEDCT_US:206785008
database_cross_reference: SNOMEDCT_US:43724002

Shivering
type: Class
subclass of: Constitutional symptom
definition: Involuntary contraction or twitching of the muscles.
PMOID: PMO:00014114
Subclass_of: Constitutional symptom
Synonym: Shuddering
Tree Number: T3.23.11
database_cross_reference: HPO:HP:0025144

Rigors
type: Class
subclass of: Chills
definition: Severe chills with violent shivering. A rigor is an episode of shaking or exaggerated shivering which can occur with a high fever.
PMOID: PMO:00014055
Subclass_of: Chills
Synonym: AGUE
Synonym: CHILL SHAKING
Synonym: Having rigors
Synonym: Having rigors (finding)
Synonym: RIGOR
Synonym: RIGORS
Synonym: Rigor
Synonym: Rigor (finding)
Synonym: Rigor - Temperature-associated observation
Synonym: Rigor - symptom
Tree Number: T3.23.4.1
database_cross_reference: CCPSS:0013247
database_cross_reference: CCPSS:1014687
database_cross_reference: CHV:0000033399
database_cross_reference: CST:CHILLS
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U003390
database_cross_reference: HPO:HP:0025145
database_cross_reference: ICPC2P:A02004
database_cross_reference: MDR:10039175
database_cross_reference: MDR:10039176
database_cross_reference: MDR:10039177
database_cross_reference: MDR:10076336
database_cross_reference: MDR:10076459
database_cross_reference: MEDCIN:6020
database_cross_reference: MEDCIN:8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C111658
database_cross_reference: NCI_NICHD:C111658
database_cross_reference: RCD:X76EQ
database_cross_reference: RCD:XE0qf
database_cross_reference: RCD:Xa96g
database_cross_reference: SNMI:F-03266
database_cross_reference: SNOMEDCT_US:139110001
database_cross_reference: SNOMEDCT_US:161854004
database_cross_reference: SNOMEDCT_US:248457000
database_cross_reference: SNOMEDCT_US:267027008
database_cross_reference: SNOMEDCT_US:38880002

Abnormality of hepatobiliary system physiology
type: Class
subclass of: Abnormality of digestive system physiology
definition: A fiunctional anomaly of the hepatobiliary system
PMOID: PMO:00005361
Subclass_of: Abnormality of digestive system physiology
Tree Number: T3.10.3.3
database_cross_reference: HPO:HP:0025155

Dependency on intravenous nutrition
type: Class
subclass of: Abnormality of digestive system physiology
definition: Inability to be weaned from intravenous (parenteral) nutrition, as judged by the hydration status (urine output, blood urea nitrogen, creatinine, urine sodium concentration), ability to maintain weight, stool output, and serum electrolyte status.
PMOID: PMO:00005370
Subclass_of: Abnormality of digestive system physiology
Tree Number: T3.10.3.4
database_cross_reference: HPO:HP:0025156

Increased urinary sedoheptulose
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increased concentration of sedoheptulose in the urine. Sedoheptulose is a monosaccharide with seven carbon atoms and a ketone functional group.
PMOID: PMO:00003759
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.31
database_cross_reference: HPO:HP:0025157

Abdominal aseptic abscess
type: Class
subclass of: Abnormality of abdomen morphology
definition: An abscess-like lesion located within the abdomen. The lesions are localized in the spleen, liver, abdominal lymph nodes. The lesions represent visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids, but relapses occur frequently.
PMOID: PMO:00005301
Subclass_of: Abnormality of abdomen morphology
Tree Number: T3.10.1.1
database_cross_reference: HPO:HP:0025181

Abnormal apolipoprotein level
type: Class
subclass of: Abnormality of circulating protein level
definition: A deviation from the normal concentration in blood of an apolipoprotein, i.e., of a protein that binds lipids to form lipoprotein and is thereby responsible for the transport of lipids in the blood and lymph circulation.
PMOID: PMO:00003919
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.2
database_cross_reference: HPO:HP:0025201

Abnormality of synovial bursa morphology
type: Class
subclass of: Abnormality of skeletal morphology
definition: A structural anomaly of a synovial bursa.
PMOID: PMO:00013950
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.9
database_cross_reference: HPO:HP:0025231

Foot pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the foot.
PMOID: PMO:00014095
Subclass_of: Pain
Synonym: FOOT PAIN
Synonym: Foot Pain
Synonym: Foot pain (finding)
Synonym: Hindfoot painful
Synonym: PAIN FOOT
Synonym: Pain foot
Synonym: Pain in foot
Synonym: Pain;foot/feet
Synonym: Pain;musculoskeletal;foot/feet
Synonym: Podalgia
Tree Number: T3.23.10.16
database_cross_reference: CCPSS:1017510
database_cross_reference: CHV:0000005192
database_cross_reference: COSTAR:311
database_cross_reference: CST:PAIN
database_cross_reference: DXP:U001576
database_cross_reference: HPO:HP:0025238
database_cross_reference: ICPC2P:L17001
database_cross_reference: ICPC2P:L17002
database_cross_reference: MDR:10016974
database_cross_reference: MDR:10033400
database_cross_reference: MDR:10033429
database_cross_reference: MEDCIN:362303
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34618
database_cross_reference: RCD:X75sD
database_cross_reference: SNMI:F-18A34
database_cross_reference: SNOMEDCT_US:203124006
database_cross_reference: SNOMEDCT_US:203126008
database_cross_reference: SNOMEDCT_US:389344003
database_cross_reference: SNOMEDCT_US:390077002
database_cross_reference: SNOMEDCT_US:47933007
database_cross_reference: SNOMEDCT_VET:47933007

Abnormality of skin adnexa physiology
type: Class
subclass of: Abnormality of the integument
definition: Any functional anomaly of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands.
PMOID: PMO:00008943
Subclass_of: Abnormality of the integument
Tree Number: T3.16.2
database_cross_reference: HPO:HP:0025276

Gustatory sweating
type: Class
subclass of: Abnormality of skin adnexa physiology
definition: Hyperhidrosis that occurs with gustatory stimulation (e.g., moisture on face from sweating that occurs after eating).
PMOID: PMO:00008947
Subclass_of: Abnormality of skin adnexa physiology
Synonym: Baillarger syndrome
Synonym: Frey syndrome
Synonym: Gustatory Hyperhidroses
Synonym: Gustatory Hyperhidrosis
Synonym: Gustatory Sweating
Synonym: Gustatory hyperhidrosis
Synonym: Gustatory hyperhidrosis (disorder)
Synonym: Gustatory sweating (finding)
Synonym: HYPERHIDROSIS, GUSTATORY
Synonym: HYPRG
Tree Number: T3.16.2.4
database_cross_reference: CHV:0000011954
database_cross_reference: DO:DOID:11599
database_cross_reference: HPO:HP:0025277
database_cross_reference: MSH:D013547
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000002869
database_cross_reference: OMIM:144100
database_cross_reference: RCD:X50AV
database_cross_reference: SNM:F-03640
database_cross_reference: SNMI:F-42270
database_cross_reference: SNOMEDCT_US:238758008
database_cross_reference: SNOMEDCT_US:56046002

Cold-induced sweating
type: Class
subclass of: Abnormality of skin adnexa physiology
definition: Sweating provoked by cold temperature rather than by heat.
PMOID: PMO:00008945
Subclass_of: Abnormality of skin adnexa physiology
Tree Number: T3.16.2.2
database_cross_reference: HPO:HP:0025278

Abnormal cellular phenotype
type: Class
subclass of: Phenotypic Abnormality
definition: An anomaly of cellular morphology or physiology.
PMOID: PMO:00000867
Subclass_of: Phenotypic Abnormality
Tree Number: T3.1
database_cross_reference: HPO:HP:0025354

Abnormality of growth plate morphology
type: Class
subclass of: Abnormality of skeletal morphology
definition: A structural anomaly of the growth plates (epiphyseal plates), areas of cartilage located near the ends of long bones that are located between the metaphysis (widened part of the shaft of the bone) and the epiphysis (end of the bone) and in which growth occurs in the developing bone. After conclusion of bone growth, the growth plates ossify (harden into solid bone).
PMOID: PMO:00013948
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.8
database_cross_reference: HPO:HP:0025368

Diet-resistant subcutaneous adipose tissue
type: Class
subclass of: Abnormal adipose tissue morphology
definition: Areas of subcutanous fat tissue that are resistant to (do not respond as expected to) diet, life-style alteration, or bariatric surgery.
PMOID: PMO:00001285
Subclass_of: Abnormal adipose tissue morphology
Tree Number: T3.3.1.5
database_cross_reference: HPO:HP:0025384

Staring gaze
type: Class
subclass of: Abnormal eye physiology
definition: An abnormality in which the eyes are held permanently wide open.
PMOID: PMO:00007482
Subclass_of: Abnormal eye physiology
Synonym: Staring eyes
Tree Number: T3.13.2.15
database_cross_reference: HPO:HP:0025401

Asthenia
type: Class
subclass of: Constitutional symptom
definition: A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.
PMOID: PMO:00014048
Subclass_of: Constitutional symptom
Synonym: ASTHENIA
Synonym: Asthenia (finding)
Synonym: Asthenia NOS
Synonym: Asthenia [D]
Synonym: Asthenia [D] (finding)
Synonym: Asthenia [D] (situation)
Synonym: Asthenia [Disease/Finding]
Synonym: Asthenias
Synonym: Asthenic
Synonym: [D]Asthenia
Tree Number: T3.23.1
database_cross_reference: AOD:0000006718
database_cross_reference: BI:BI00549
database_cross_reference: CHV:0000001539
database_cross_reference: CST:ASTHENIA
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0025406
database_cross_reference: ICD10CM:R53.1
database_cross_reference: LCH:U000403
database_cross_reference: LCH_NW:sh85008856
database_cross_reference: MDR:10003549
database_cross_reference: MEDCIN:278510
database_cross_reference: MSH:D001247
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:780.79
database_cross_reference: NCI:C28132
database_cross_reference: NCI_NCI-GLOSS:CDR0000044787
database_cross_reference: NDFRT:N0000000496
database_cross_reference: PSY:04170
database_cross_reference: RCD:R0072
database_cross_reference: RCD:XM0yx
database_cross_reference: RCD:XM1AV
database_cross_reference: RCDSY:R0072
database_cross_reference: SNM:F-01620
database_cross_reference: SNMI:F-01380
database_cross_reference: SNOMEDCT_US:13791008
database_cross_reference: SNOMEDCT_US:158170006
database_cross_reference: SNOMEDCT_US:206768006
database_cross_reference: SNOMEDCT_US:274236006
database_cross_reference: SNOMEDCT_US:274638001

Pneumomediastinum
type: Class
subclass of: Abnormality of the mediastinum
definition: The presence of free air in the mediastinum.
PMOID: PMO:00014018
Subclass_of: Abnormality of the mediastinum
Synonym: Emphysema, Mediastinal
Synonym: Emphysemas, Mediastinal
Synonym: MEDIASTINAL EMPHYSEMA
Synonym: Mediastinal Emphysema
Synonym: Mediastinal Emphysema [Disease/Finding]
Synonym: Mediastinal Emphysemas
Synonym: Mediastinal emphysema
Synonym: Mediastinal emphysema (disorder)
Synonym: Mediastinal emphysema [Ambiguous]
Synonym: PNEUMOMEDIASTINUM
Tree Number: T3.21.1.2
database_cross_reference: CCPSS:1010260
database_cross_reference: CHV:0000007837
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001524
database_cross_reference: DXP:U002531
database_cross_reference: HPO:HP:0025421
database_cross_reference: ICD10CM:J98.2
database_cross_reference: LCH:U006003
database_cross_reference: LCH_NW:sh85103623
database_cross_reference: MDR:10027073
database_cross_reference: MDR:10050184
database_cross_reference: MEDCIN:33000
database_cross_reference: MSH:D008478
database_cross_reference: MTHICD9:518.1
database_cross_reference: NCI:C98981
database_cross_reference: NCI_NICHD:C98981
database_cross_reference: NDFRT:N0000001961
database_cross_reference: RCD:H581.
database_cross_reference: SNM:M-36270
database_cross_reference: SNMI:D2-81180
database_cross_reference: SNOMEDCT_US:155627006
database_cross_reference: SNOMEDCT_US:16838000
database_cross_reference: SNOMEDCT_US:196144009
database_cross_reference: SNOMEDCT_US:266411000
database_cross_reference: SNOMEDCT_US:390899006

Abnormal bronchus physiology
type: Class
subclass of: Functional respiratory abnormality
definition: Any anomaly of the function of the bronchi.
PMOID: PMO:00011574
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.3
database_cross_reference: HPO:HP:0025427

Abnormal cry
type: Class
subclass of: Abnormality of the voice
definition: Any anomaly of the vocalizing of an infant's crying, i.e.,the typically loud voice production that is accompanied by tears and agitation.
PMOID: PMO:00014020
Subclass_of: Abnormality of the voice
Tree Number: T3.22.1
database_cross_reference: HPO:HP:0025429

High-pitched cry
type: Class
subclass of: Abnormal cry
definition: A type of crying in an abnormally high-pitched voice.
PMOID: PMO:00014022
Subclass_of: Abnormal cry
Tree Number: T3.22.1.2
database_cross_reference: HPO:HP:0025430

Staccato cry
type: Class
subclass of: Abnormal cry
definition: A type of cry that is abnormal because it is consists of unusually shortened and detached vocalizations.
PMOID: PMO:00014023
Subclass_of: Abnormal cry
Tree Number: T3.22.1.3
database_cross_reference: HPO:HP:0025431

Decreased lecithin cholesterol acyl transferase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: Reduced activity of the enzyme lecithin cholesterol acyl transferase.
PMOID: PMO:00003580
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.9
database_cross_reference: HPO:HP:0025433

Abnormal cardiac atrial physiology
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: An abnormality of the function of the cardiac atria.
PMOID: PMO:00004714
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.1
database_cross_reference: HPO:HP:0025443

Abnormal cell morphology
type: Class
subclass of: Abnormal cellular phenotype
definition: Any anomaly of cell structure.
PMOID: PMO:00000868
Subclass_of: Abnormal cellular phenotype
Tree Number: T3.1.1
database_cross_reference: HPO:HP:0025461

Abnormality of redox activity
type: Class
subclass of: Abnormal cellular physiology
definition: An abnormality of the processes that maintain the redox environment of a cell or compartment within a cell, that is, the balance between reduction and oxidation chemical reactions.
PMOID: PMO:00003498
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.7
database_cross_reference: HPO:HP:0025463

Abnormal circulating beta globulin level
type: Class
subclass of: Abnormality of circulating protein level
definition: A deviation from the normal concentration of beta globulin. The beta globulins are a group of globular (globe-shaped) proteins in blood.
PMOID: PMO:00003926
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.4
database_cross_reference: HPO:HP:0025465

Periarticular calcification
type: Class
subclass of: Ectopic calcification
definition: Calcified deposits in soft tissue structures outside a joint.
PMOID: PMO:00014011
Subclass_of: Ectopic calcification
Synonym: Periarticular calcification (disorder)
Tree Number: T3.20.4.7
database_cross_reference: HPO:HP:0025477
database_cross_reference: RCD:X40R2
database_cross_reference: SNOMEDCT_US:237898004

Abnormal circulating thyroglobulin level
type: Class
subclass of: Abnormality of circulating protein level
definition: A deviation from the normal concentration of thyroglobulin, a protein produced in the thyroid gland that acts as a precursor to thyrroid hormones.
PMOID: PMO:00003937
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.6
database_cross_reference: HPO:HP:0025483

Calcinosis cutis
type: Class
subclass of: Ectopic calcification
definition: Deposition of calcium in the skin.
PMOID: PMO:00014001
Subclass_of: Ectopic calcification
Synonym: Calcinosis Cutis
Synonym: Calcinosis cutis (disorder)
Synonym: Cutaneous calcification
Synonym: Dystrophic calc of skin
Synonym: Dystrophic calcification of skin
Synonym: calcinosis cutis
Synonym: calcinosis cutis (diagnosis)
Tree Number: T3.20.4.2
database_cross_reference: CHV:0000002287
database_cross_reference: COSTAR:NOCODE
database_cross_reference: HPO:HP:0025520
database_cross_reference: ICD10:L94.2
database_cross_reference: ICD10AM:L94.2
database_cross_reference: ICD10CM:L94.2
database_cross_reference: MDR:10074496
database_cross_reference: MDR:10074505
database_cross_reference: MEDCIN:37183
database_cross_reference: MTHICD9:709.3
database_cross_reference: OMIM:MTHU039445
database_cross_reference: RCD:X40R7
database_cross_reference: SNM:M-55500
database_cross_reference: SNMI:D0-75610
database_cross_reference: SNOMEDCT_US:21323007

Increased body fat percentage
type: Class
subclass of: Growth abnormality
definition: The percentage of fat as a part of total body weight above the norm, usually defined as 32% for females and 25% for males.
PMOID: PMO:00014190
Subclass_of: Growth abnormality
Tree Number: T3.24.6
database_cross_reference: HPO:HP:0025521

Abnormal mean corpuscular hemoglobin concentration
type: Class
subclass of: Abnormal erythrocyte morphology
definition: A deviation from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced.
PMOID: PMO:00000947
Subclass_of: Abnormal erythrocyte morphology
Synonym: Abnormal MCH
Synonym: Abnormal mean corpuscular haemoglobin
Tree Number: T3.2.2.5
database_cross_reference: HPO:HP:0025546

Elevated circulating ribitol concentration
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase above the normal concentration of ribitol in the blood.
PMOID: PMO:00003733
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of ribitol in serum
Tree Number: T3.6.10.11
database_cross_reference: HPO:HP:0025550

Abnormal extraocular muscle physiology
type: Class
subclass of: Abnormal eye physiology
definition: A functional anomaly of the muscles of the eye.
PMOID: PMO:00007003
Subclass_of: Abnormal eye physiology
Tree Number: T3.13.2.1
database_cross_reference: HPO:HP:0025590

Flexion contracture of digit
type: Class
subclass of: Flexion contracture
definition: A bent (flexed) finger or toe joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints.
PMOID: PMO:00001321
Subclass_of: Flexion contracture
Tree Number: T3.3.6.4
database_cross_reference: HPO:HP:0030044

Nervous tissue neoplasm
type: Class
subclass of: Neoplasm by histology
definition: A neoplasm derived from nervous tissue (not necessarity a neoplasm located in the nervous system).
PMOID: PMO:00014330
Subclass_of: Neoplasm by histology
Synonym: NEOPL NERVE TISSUE
Synonym: NEOPL NERVOUS TISSUE
Synonym: NERVE TISSUE NEOPL
Synonym: NERVOUS TISSUE NEOPL
Synonym: Neoplasm, Nerve Tissue
Synonym: Neoplasm, Nervous Tissue
Synonym: Neoplasms, Nerve Tissue
Synonym: Neoplasms, Nerve Tissue [Disease/Finding]
Synonym: Neoplasms, Nervous Tissue
Synonym: Nerve Tissue Neoplasm
Tree Number: T3.25.2.6
database_cross_reference: DO:DOID:3093
database_cross_reference: HPO:HP:0030060
database_cross_reference: MSH:D009380
database_cross_reference: NDFRT:N0000002139

Abnormal serum testosterone level
type: Class
subclass of: Puberty and gonadal disorders
definition: An anomalous concentration of testosterone in the blood.
PMOID: PMO:00006396
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.1
database_cross_reference: HPO:HP:0030087

Excessive bleeding from superficial cuts
type: Class
subclass of: Abnormal bleeding
definition: An abnormally increased degree of bleeding following a superfical injury to the surface of the skin.
PMOID: PMO:00000914
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.7
database_cross_reference: HPO:HP:0030138

Excessive bleeding after a venipuncture
type: Class
subclass of: Abnormal bleeding
definition: An abnormal high amount of bleeding following the procedure of taking a blood sample.
PMOID: PMO:00000913
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.6
database_cross_reference: HPO:HP:0030139

Flank pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the flank.
PMOID: PMO:00014094
Subclass_of: Pain
Synonym: FLANK PAIN
Synonym: Flank Pain
Synonym: Flank Pain [Disease/Finding]
Synonym: Flank Pains
Synonym: Flank pain (finding)
Synonym: PAIN FLANK
Synonym: Pain flank
Synonym: Pain, Flank
Synonym: Pain;flank
Synonym: Pains, Flank
Tree Number: T3.23.10.15
database_cross_reference: CCPSS:1017337
database_cross_reference: CHV:0000005079
database_cross_reference: COSTAR:306
database_cross_reference: CST:PAIN BACK
database_cross_reference: CST:PAIN FLANK
database_cross_reference: DXP:U001533
database_cross_reference: HPO:HP:0030157
database_cross_reference: ICPC2P:L05001
database_cross_reference: MDR:10016750
database_cross_reference: MDR:10033399
database_cross_reference: MEDCIN:558
database_cross_reference: MSH:D021501
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34615
database_cross_reference: NCI_CTCAE:E12414
database_cross_reference: NDFRT:N0000004242
database_cross_reference: OMIM:MTHU048535
database_cross_reference: RCD:X75rg
database_cross_reference: SNOMEDCT_US:139316002
database_cross_reference: SNOMEDCT_US:162045003
database_cross_reference: SNOMEDCT_US:247355005
database_cross_reference: SNOMEDCT_US:267165003

Abnormal vascular physiology
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: Abnormality of vascular function.
PMOID: PMO:00004782
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.7
database_cross_reference: HPO:HP:0030163

Night sweats
type: Class
subclass of: Constitutional symptom
definition: Occurence of excessive sweating during sleep.
PMOID: PMO:00014073
Subclass_of: Constitutional symptom
Synonym: NIGHT SWEAT
Synonym: NIGHT SWEATS
Synonym: Night Sweating
Synonym: Night Sweats
Synonym: Night sweat
Synonym: Night sweats (finding)
Synonym: Nocturnal hyperhidrosis
Synonym: Nocturnal perspiration
Synonym: Problem;sweating;night
Synonym: night sweat
Tree Number: T3.23.9
database_cross_reference: BI:BI00355
database_cross_reference: CCPSS:1014502
database_cross_reference: CHV:0000008720
database_cross_reference: COSTAR:518
database_cross_reference: CST:SWEAT
database_cross_reference: DXP:U002804
database_cross_reference: HPO:HP:0030166
database_cross_reference: ICD10CM:R61
database_cross_reference: ICPC2P:A09002
database_cross_reference: ICPC2P:A09005
database_cross_reference: LNC:LP75171-6
database_cross_reference: LNC:MTHU013525
database_cross_reference: MDR:10029409
database_cross_reference: MDR:10029410
database_cross_reference: MDR:10052427
database_cross_reference: MEDCIN:272
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3279
database_cross_reference: NCI:MPN-SAF
database_cross_reference: NCI_NICHD:C3279
database_cross_reference: RCD:X76A5
database_cross_reference: SNM:F-03310
database_cross_reference: SNMI:F-42210
database_cross_reference: SNOMEDCT_US:139115006
database_cross_reference: SNOMEDCT_US:161859009
database_cross_reference: SNOMEDCT_US:42984000

Abnormality of muscle size
type: Class
subclass of: Abnormal muscle morphology
definition: Abnormalities of the overall muscle bulk based on clinical observation.
PMOID: PMO:00009542
Subclass_of: Abnormal muscle morphology
Tree Number: T3.17.1.2
database_cross_reference: HPO:HP:0030236

Maternal fever in pregnancy
type: Class
subclass of: Prenatal maternal abnormality
definition: The occurence of an elevated body temperature of the mother during pregnancy.
PMOID: PMO:00004396
Subclass_of: Prenatal maternal abnormality
Synonym: Maternal fever during pregnancy
Tree Number: T3.7.11.6
database_cross_reference: HPO:HP:0030244

Hyperplastic callus formation
type: Class
subclass of: Abnormality of skeletal morphology
definition: Increased growth of callus, the bony and cartilaginous material that forms a connecting bridge across a bone fracture during fracture healing.
PMOID: PMO:00013955
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.13
database_cross_reference: HPO:HP:0030268

Reduced erythrocyte 2,3-diphosphoglycerate concentration
type: Class
subclass of: Abnormal erythrocyte morphology
definition: 2,3-diphosphoglycerate (2,3-DPG) controls the movement of oxygen from red blood cells to tissues. Anemia is usually accompanied by an increased level of 2,3-DPG in order to promote tissue oxygenation. This term refers to an inappropriate low 2,3-DPG concentration in erythrocytes.
PMOID: PMO:00001029
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.17
database_cross_reference: HPO:HP:0030271

Abnormal erythrocyte enzyme activity
type: Class
subclass of: Abnormal erythrocyte morphology
definition: An altered ability of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered levels of an enzyme.
PMOID: PMO:00000925
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.1
database_cross_reference: HPO:HP:0030272

Abnormal periosteum morphology
type: Class
subclass of: Abnormality of the periosteum
definition: An anomalous structure of the periosteum, i.e., of the membrane that covers the outer surface of bones.
PMOID: PMO:00013994
Subclass_of: Abnormality of the periosteum
Tree Number: T3.20.3.1
database_cross_reference: HPO:HP:0030313

Abnormal circulating gonadotropin level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An anomaly of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
PMOID: PMO:00006151
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.5
database_cross_reference: HPO:HP:0030338

Abnormal circulating androgen level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An anomaly in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.
PMOID: PMO:00006133
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.3
database_cross_reference: HPO:HP:0030347

Abnormal serum insulin-like growth factor 1 level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An anomalous level of insulin-like growth factor 1 (IGF1) in the blood circulation.
PMOID: PMO:00006172
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.11
database_cross_reference: HPO:HP:0030352

Vaginal birth after Caesarian
type: Class
subclass of: Abnormal delivery
definition: Vaginal birth after Caesarian (VBAC) refers to the situation where the mother has had a previous Cesarean delivery but has now delivered vaginally.
PMOID: PMO:00004311
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.11
database_cross_reference: HPO:HP:0030365

Delivery by Odon device
type: Class
subclass of: Abnormal delivery
definition: The Odon device is an instrument for assisted vaginal deliveries that is applied on the head of the baby and used to apply traction to assist the birth process.
PMOID: PMO:00004301
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.3
database_cross_reference: HPO:HP:0030366

Induced vaginal delivery
type: Class
subclass of: Abnormal delivery
definition: Vaginal delivery following induction of labor, a procedure used to stimulate uterine contractions during pregnancy before labor begins on its own.
PMOID: PMO:00004303
Subclass_of: Abnormal delivery
Tree Number: T3.7.1.5
database_cross_reference: HPO:HP:0030369

Therapeutic abortion
type: Class
subclass of: Abnormal delivery
definition: Delivery by means of therapeutic termination of pregnancy. Therapeutic abortion may be done to end a pregnancy if the mother's life is in danger or if the baby has abnormalities involving the major organ systems and is not expected to survive after birth or by choice.
PMOID: PMO:00004310
Subclass_of: Abnormal delivery
Synonym: Therapeutic Abortion with Complications
Tree Number: T3.7.1.10
database_cross_reference: HPO:HP:0030449
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:D8-04202

Abnormal visual electrophysiology
type: Class
subclass of: Abnormal eye physiology
PMOID: PMO:00007051
Subclass_of: Abnormal eye physiology
Tree Number: T3.13.2.5
database_cross_reference: HPO:HP:0030453

Cone dysfunction syndrome
type: Class
subclass of: Abnormal eye physiology
definition: Retinal phenotype characterised by cone photoreceptor dysfunction and preserved rod system. The abnormality is typically stationary or very slowly progressive and findings may include reduced central vision, colour vision abnormalities, nystagmus and photophobia.
PMOID: PMO:00007438
Subclass_of: Abnormal eye physiology
Synonym: Cone dysfunction
Tree Number: T3.13.2.10
database_cross_reference: HPO:HP:0030637
database_cross_reference: SNM:D-X017

Abnormality of cardiovascular system morphology
type: Class
subclass of: Abnormality of the cardiovascular system
definition: Any structural anomaly of the heart and great vessels.
PMOID: PMO:00004450
Subclass_of: Abnormality of the cardiovascular system
Synonym: Cardiovascular malformations
Tree Number: T3.9.2
database_cross_reference: HPO:HP:0030680
database_cross_reference: MTH:NOCODE

Abnormal adiponectin level
type: Class
subclass of: Abnormality of circulating hormone level
definition: A deviation from the normal circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue, and that plays a crucial role in the regulation of insulin sensitivity and glucose metabolism.
PMOID: PMO:00006127
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.1
database_cross_reference: HPO:HP:0030684

Abnormal glucagon level
type: Class
subclass of: Abnormality of circulating hormone level
definition: A deviation from the normal concentration of glucagon in the blood circulation.
PMOID: PMO:00006166
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.9
database_cross_reference: HPO:HP:0030687

Intrauterine fetal demise of one twin after midgestation
type: Class
subclass of: Abnormality of prenatal development or birth
definition: Loss of one twin occurring after midgestation (17 weeks gestation).
PMOID: PMO:00004362
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.7
database_cross_reference: HPO:HP:0030753

Adipocyte hypertrophy
type: Class
subclass of: Abnormal adipose tissue morphology
definition: An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy.
PMOID: PMO:00001274
Subclass_of: Abnormal adipose tissue morphology
Synonym: Fat cell hypertrophy
Tree Number: T3.3.1.3
database_cross_reference: HPO:HP:0030759

Ear pain
type: Class
subclass of: Pain
definition: Pain in the ear can be a consequence of otologic disease (primary or otogenic otalgia), or can arise from pathologic processes and structures other than the ear (secondary or referred otalgia).
PMOID: PMO:00014090
Subclass_of: Pain
Synonym: (Otalgia) or (ear pain)
Synonym: (Otalgia) or (ear pain) (disorder)
Synonym: EAR PAIN
Synonym: EARACHE
Synonym: Ear Pain
Synonym: Ear ache
Synonym: Ear pain (finding)
Synonym: Earache
Synonym: Earache NOS
Synonym: Earache [Disease/Finding]
Tree Number: T3.23.10.11
database_cross_reference: CCPSS:1003417
database_cross_reference: CHV:0000004232
database_cross_reference: COSTAR:268
database_cross_reference: COSTAR:269
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:PAIN EAR
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001049
database_cross_reference: HPO:HP:0030766
database_cross_reference: ICD10:H92.0
database_cross_reference: ICD10AM:H92.0
database_cross_reference: ICD10CM:H92.0
database_cross_reference: ICD10CM:H92.09
database_cross_reference: ICD9CM:388.7
database_cross_reference: ICD9CM:388.70
database_cross_reference: ICPC2P:H01001
database_cross_reference: ICPC2P:H01002
database_cross_reference: LCH_NW:sh87007264
database_cross_reference: MDR:10013992
database_cross_reference: MDR:10014020
database_cross_reference: MDR:10014037
database_cross_reference: MDR:10031304
database_cross_reference: MDR:10031305
database_cross_reference: MDR:10033393
database_cross_reference: MDR:10033423
database_cross_reference: MEDCIN:147
database_cross_reference: MEDCIN:212827
database_cross_reference: MSH:D004433
database_cross_reference: MTH:269
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:388.70
database_cross_reference: NCI:C37944
database_cross_reference: NCI_CTCAE:E10262
database_cross_reference: NDFRT:N0000001038
database_cross_reference: RCD:1C3..
database_cross_reference: RCD:1C3Z.
database_cross_reference: RCD:F5870
database_cross_reference: RCD:F587z
database_cross_reference: RCD:XE2vk
database_cross_reference: RCD:Xa8Hm
database_cross_reference: SNM:F-X6200
database_cross_reference: SNMI:DA-90100
database_cross_reference: SNOMEDCT_US:139625000
database_cross_reference: SNOMEDCT_US:139630001
database_cross_reference: SNOMEDCT_US:155251005
database_cross_reference: SNOMEDCT_US:16001004
database_cross_reference: SNOMEDCT_US:162356005
database_cross_reference: SNOMEDCT_US:162361007
database_cross_reference: SNOMEDCT_US:194406008
database_cross_reference: SNOMEDCT_US:194407004
database_cross_reference: SNOMEDCT_US:194408009
database_cross_reference: SNOMEDCT_US:302219006

Abnormal visual accommodation
type: Class
subclass of: Abnormal eye physiology
definition: An anomaly in the process of visual accommodation, which is the process of adjustment of the eye to enable sharp vision of objects at different distances. Accommodation is mediated by contraction of the ciliary muscles, which alter the convexity of the lens and, consequently, its refractive power.
PMOID: PMO:00007049
Subclass_of: Abnormal eye physiology
Tree Number: T3.13.2.4
database_cross_reference: HPO:HP:0030800

Abnormal breath sound
type: Class
subclass of: Functional respiratory abnormality
definition: An anomalous (adventitious) sound produced by the breathing process.
PMOID: PMO:00011559
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.2
database_cross_reference: HPO:HP:0030829

Neck pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the neck.
PMOID: PMO:00014107
Subclass_of: Pain
Synonym: (Cervicalgia) or (neck pain NOS)
Synonym: (Cervicalgia) or (neck pain NOS) (disorder)
Synonym: Ache, Neck
Synonym: Aches, Neck
Synonym: CERVICAL PAIN
Synonym: Cervical Pain
Synonym: Cervical Pains
Synonym: Cervical pain
Synonym: Cervicalgia
Synonym: Cervicalgia - pain in neck
Tree Number: T3.23.10.24
database_cross_reference: BI:BI00502
database_cross_reference: CCPSS:1015874
database_cross_reference: CHV:0000002693
database_cross_reference: COSTAR:510
database_cross_reference: CST:PAIN NECK
database_cross_reference: DXP:U000628
database_cross_reference: DXP:U002767
database_cross_reference: HPO:HP:0030833
database_cross_reference: ICD10:M54.2
database_cross_reference: ICD10AM:M54.2
database_cross_reference: ICD10CM:M54.2
database_cross_reference: ICD9CM:723.1
database_cross_reference: ICPC2P:L01004
database_cross_reference: ICPC2P:L01006
database_cross_reference: LCH_NW:sh85090564
database_cross_reference: MDR:10008296
database_cross_reference: MDR:10008322
database_cross_reference: MDR:10028836
database_cross_reference: MDR:10033467
database_cross_reference: MDR:10049860
database_cross_reference: MEDCIN:231
database_cross_reference: MEDCIN:34440
database_cross_reference: MSH:D019547
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:723.1
database_cross_reference: NCI:C50663
database_cross_reference: NCI_CTCAE:E12493
database_cross_reference: NCI_FDA:2433
database_cross_reference: NDFRT:N0000003931
database_cross_reference: OMIM:MTHU023845
database_cross_reference: RCD:XE1F4
database_cross_reference: SNMI:F-16250
database_cross_reference: SNOMEDCT_US:156641005
database_cross_reference: SNOMEDCT_US:202764005
database_cross_reference: SNOMEDCT_US:268078004
database_cross_reference: SNOMEDCT_US:81680005

Shoulder pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the shoulder.
PMOID: PMO:00014110
Subclass_of: Pain
Tree Number: T3.23.10.26
database_cross_reference: HPO:HP:0030834

Elbow pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the elbow.
PMOID: PMO:00014091
Subclass_of: Pain
Synonym: ELBOW PAIN
Synonym: Pain in elbow
Synonym: Pain in elbow (finding)
Synonym: Pain in the elbows
Synonym: Pain in unspecified elbow
Synonym: Pain;elbow
Synonym: Pain;musculoskeletal;elbow
Synonym: elbow pain
Synonym: elbow pains
Synonym: elbows pain
Tree Number: T3.23.10.12
database_cross_reference: CCPSS:0058035
database_cross_reference: CHV:0000024178
database_cross_reference: DXP:U001098
database_cross_reference: HPO:HP:0030835
database_cross_reference: ICD10CM:M25.52
database_cross_reference: ICD10CM:M25.529
database_cross_reference: ICPC2P:L10001
database_cross_reference: ICPC2P:L10002
database_cross_reference: MDR:10033424
database_cross_reference: OMIM:MTHU027318
database_cross_reference: RCD:Xa35V
database_cross_reference: SNMI:F-17350
database_cross_reference: SNOMEDCT_US:74323005

Wrist pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the wrist.
PMOID: PMO:00014113
Subclass_of: Pain
Synonym: Ache wrists
Synonym: Arthralgia of wrist
Synonym: Pain in wrist
Synonym: Pain in wrist (finding)
Synonym: Pain;musculoskeletal;wrist
Synonym: Pain;wrist
Synonym: WRIST ARTHRALGIA
Synonym: WRIST PAIN
Synonym: Wrist arthralgia
Synonym: Wrist joint pain
Tree Number: T3.23.10.29
database_cross_reference: BI:BI00504
database_cross_reference: CCPSS:0061761
database_cross_reference: CCPSS:1016217
database_cross_reference: CHV:0000021489
database_cross_reference: CHV:0000033193
database_cross_reference: COSTAR:U000624
database_cross_reference: DXP:U004491
database_cross_reference: HPO:HP:0030836
database_cross_reference: ICD10CM:M25.53
database_cross_reference: ICPC2P:L11001
database_cross_reference: ICPC2P:L11002
database_cross_reference: MDR:10000430
database_cross_reference: MDR:10048692
database_cross_reference: MEDCIN:315886
database_cross_reference: MEDCIN:939
database_cross_reference: OMIM:MTHU016462
database_cross_reference: RCD:N094F
database_cross_reference: SNMI:F-176A0
database_cross_reference: SNOMEDCT_US:156596005
database_cross_reference: SNOMEDCT_US:202471001
database_cross_reference: SNOMEDCT_US:202482009
database_cross_reference: SNOMEDCT_US:56608008

Finger pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the finger.
PMOID: PMO:00014093
Subclass_of: Pain
Synonym: FINGER PAIN
Synonym: Finger pain (finding)
Synonym: Pain in finger
Synonym: Pain in finger (finding)
Synonym: Pain in fingers
Synonym: Pain;finger(s)
Synonym: Pain;musculoskeletal;finger(s)
Synonym: finger pain
Synonym: fingers pain
Synonym: limb pain finger
Tree Number: T3.23.10.14
database_cross_reference: CCPSS:0030607
database_cross_reference: CHV:0000024231
database_cross_reference: DXP:U001505
database_cross_reference: HPO:HP:0030837
database_cross_reference: ICPC2P:L12001
database_cross_reference: ICPC2P:L12002
database_cross_reference: MDR:10033428
database_cross_reference: MEDCIN:362297
database_cross_reference: RCD:XM1NJ
database_cross_reference: SNMI:F-176C0
database_cross_reference: SNOMEDCT_US:18876004
database_cross_reference: SNOMEDCT_US:203125007
database_cross_reference: SNOMEDCT_US:275317007

Hip pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the hip.
PMOID: PMO:00014097
Subclass_of: Pain
Synonym: Arthralgia (hip)
Synonym: Arthralgia of hip
Synonym: Arthralgia of the hip
Synonym: Coxalgia
Synonym: HIP ARTHRALGIA
Synonym: HIP PAIN
Synonym: HIP PAIN MUSCULOSKELETAL
Synonym: Hip Pain
Synonym: Hip arthralgia
Synonym: Hip joint pain
Tree Number: T3.23.10.18
database_cross_reference: BI:BI00496
database_cross_reference: CCPSS:0041473
database_cross_reference: CCPSS:1008598
database_cross_reference: CCPSS:1017226
database_cross_reference: CHV:0000006146
database_cross_reference: COSTAR:368
database_cross_reference: DXP:U001976
database_cross_reference: HPO:HP:0003365
database_cross_reference: HPO:HP:0030838
database_cross_reference: ICD10CM:M25.55
database_cross_reference: ICD10CM:M25.559
database_cross_reference: ICPC2P:L13001
database_cross_reference: ICPC2P:L13002
database_cross_reference: LNC:MTHU020861
database_cross_reference: MDR:10011249
database_cross_reference: MDR:10033432
database_cross_reference: MDR:10033509
database_cross_reference: MEDCIN:315892
database_cross_reference: MEDCIN:943
database_cross_reference: NCI:C34699
database_cross_reference: OMIM:MTHU000886
database_cross_reference: OMIM:MTHU018890
database_cross_reference: OMIM:MTHU041420
database_cross_reference: RCD:X75rv
database_cross_reference: SNMI:F-18250
database_cross_reference: SNOMEDCT_US:156592007
database_cross_reference: SNOMEDCT_US:156598006
database_cross_reference: SNOMEDCT_US:202473003
database_cross_reference: SNOMEDCT_US:202486007
database_cross_reference: SNOMEDCT_US:268065004
database_cross_reference: SNOMEDCT_US:49218002
database_cross_reference: SNOMEDCT_VET:49218002

Knee pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee.
PMOID: PMO:00014099
Subclass_of: Pain
Tree Number: T3.23.10.20
database_cross_reference: HPO:HP:0030839

Ankle pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the ankle.
PMOID: PMO:00014080
Subclass_of: Pain
Synonym: ANKLE PAIN
Synonym: Ankle arthralgia
Synonym: Ankle joint pain
Synonym: Ankle joint pain (finding)
Synonym: Ankle pain (finding)
Synonym: Arthralgia of ankle
Synonym: PAIN ANKLE
Synonym: Pain ankle
Synonym: Pain in ankle
Synonym: Pain;ankle
Tree Number: T3.23.10.4
database_cross_reference: CCPSS:1017361
database_cross_reference: CHV:0000024081
database_cross_reference: CST:PAIN
database_cross_reference: DXP:U000193
database_cross_reference: HPO:HP:0030840
database_cross_reference: ICPC2P:L16001
database_cross_reference: ICPC2P:L16002
database_cross_reference: MDR:10033379
database_cross_reference: MDR:10033420
database_cross_reference: MDR:10033501
database_cross_reference: MEDCIN:337339
database_cross_reference: MEDCIN:945
database_cross_reference: OMIM:MTHU016464
database_cross_reference: RCD:N094P
database_cross_reference: RCD:X75sF
database_cross_reference: SNOMEDCT_US:202475005
database_cross_reference: SNOMEDCT_US:202490009
database_cross_reference: SNOMEDCT_US:203124006
database_cross_reference: SNOMEDCT_US:247373008

Toe pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the toe.
PMOID: PMO:00014111
Subclass_of: Pain
Tree Number: T3.23.10.27
database_cross_reference: HPO:HP:0030841

Cardiac amyloidosis
type: Class
subclass of: Amyloidosis
definition: Extracellular deposition in cardiac tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding.
PMOID: PMO:00004240
Subclass_of: Amyloidosis
Synonym: AS transthyretin amyloidosis
Synonym: Amyloid cardiomyopathy
Synonym: Amyloid heart disease
Synonym: Amyloid heart muscle disease
Synonym: Amyloidosis of heart
Synonym: Amyloidosis of heart (disorder)
Synonym: Senile cardiac amyloidosis
Synonym: Senile cardiac amyloidosis (disorder)
Synonym: amyloid cardiomyopathy
Synonym: amyloid heart disease
Tree Number: T3.6.24.2
database_cross_reference: CHV:0000026303
database_cross_reference: HPO:HP:0030843
database_cross_reference: MDR:10002020
database_cross_reference: MDR:10007509
database_cross_reference: MEDCIN:313022
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:G5570
database_cross_reference: SNM:D-7122
database_cross_reference: SNMI:D6-94710
database_cross_reference: SNOMEDCT_US:16573007
database_cross_reference: SNOMEDCT_VET:318301000009103

Heterotaxy
type: Class
subclass of: Growth abnormality
definition: An abnormality in which the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body.
PMOID: PMO:00014182
Subclass_of: Growth abnormality
Synonym: Ambiguus Viscerum, Situs
Synonym: Ambiguus Viscerums, Situs
Synonym: Ambiguus, Situs
Synonym: Heterotaxia
Synonym: Heterotaxies, Visceral
Synonym: Heterotaxis
Synonym: Heterotaxy, Visceral
Synonym: Isomerism sequence
Synonym: Laterality sequence
Synonym: Laterality sequence (disorder)
Tree Number: T3.24.5
database_cross_reference: CHV:0000011378
database_cross_reference: HPO:HP:0001696
database_cross_reference: HPO:HP:0030853
database_cross_reference: JABL:341
database_cross_reference: MDR:10067265
database_cross_reference: MSH:D059446
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C87083
database_cross_reference: NCI_NICHD:C87083
database_cross_reference: OMIM:MTHU043055
database_cross_reference: SNM:M-22120
database_cross_reference: SNMI:D4-01510
database_cross_reference: SNMI:D4-D0050
database_cross_reference: SNOMEDCT_US:14821001
database_cross_reference: SNOMEDCT_US:24614000

Abnormal cardiac ventricular function
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: An abnormality of the cardiac ventricular function.
PMOID: PMO:00004717
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.2
database_cross_reference: HPO:HP:0030872

Abnormality of pulmonary circulation
type: Class
subclass of: Functional respiratory abnormality
definition: A functional anomaly of that portion of the cardiosvascular system that carries deoxygenated blood from the heart to the lungs and returns oxygenated blood back to the heart.
PMOID: PMO:00011609
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal pulmonary circulation
Synonym: Abnormality of respiratory circulation
Tree Number: T3.19.2.9
database_cross_reference: HPO:HP:0030875

Abnormality on pulmonary function testing
type: Class
subclass of: Functional respiratory abnormality
definition: Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography.
PMOID: PMO:00011618
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal pulmonary function test
Tree Number: T3.19.2.10
database_cross_reference: HPO:HP:0030878

Abnormal response to short acting pulmonary vasodilator
type: Class
subclass of: Functional respiratory abnormality
definition: Pulmonary vasodilator testing is performed during right-heart catheterization and involves a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide. The current definition of a normal (positive) response is a drop in mean pulmonary artery pressure of at least 10 mm Hg (or 20 percent) to below 40 mm Hg.
PMOID: PMO:00011607
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.8
database_cross_reference: HPO:HP:0030893

Low APGAR score
type: Class
subclass of: Abnormality of prenatal development or birth
PMOID: PMO:00004363
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.8
database_cross_reference: HPO:HP:0030917

Low 1-minute APGAR score
type: Class
subclass of: Low APGAR score
PMOID: PMO:00004364
Subclass_of: Low APGAR score
Synonym: Low one-minute APGAR score
Tree Number: T3.7.8.1
database_cross_reference: HPO:HP:0030918

Low 5-minute APGAR score
type: Class
subclass of: Low APGAR score
PMOID: PMO:00004372
Subclass_of: Low APGAR score
Synonym: Low five-minute APGAR score
Tree Number: T3.7.8.2
database_cross_reference: HPO:HP:0030919

Vulvodynia
type: Class
subclass of: Pain
definition: Pain in the vulvar area
PMOID: PMO:00014112
Subclass_of: Pain
Synonym: Burning (of);vulva
Synonym: Burning vulva
Synonym: Vulvar pain
Synonym: Vulvodynia (disorder)
Synonym: Vulvodynia NOS
Synonym: Vulvodynia [Disease/Finding]
Synonym: Vulvodynia, unspecified
Synonym: Vulvodynias
Synonym: burning vulva
Synonym: discomfort of vulva
Tree Number: T3.23.10.28
database_cross_reference: CHV:0000023682
database_cross_reference: CHV:0000032684
database_cross_reference: HPO:HP:0030943
database_cross_reference: ICD10CM:N94.81
database_cross_reference: ICD10CM:N94.819
database_cross_reference: ICD9CM:625.7
database_cross_reference: ICD9CM:625.70
database_cross_reference: ICPC2P:X16002
database_cross_reference: LCH_NW:sh2004000507
database_cross_reference: MDR:10047781
database_cross_reference: MEDCIN:113383
database_cross_reference: MEDCIN:311473
database_cross_reference: MEDLINEPLUS:4550
database_cross_reference: MSH:D056650
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:625.70
database_cross_reference: NDFRT:N0000181144
database_cross_reference: RCD:X50GA
database_cross_reference: SNOMEDCT_US:238968009

Elevated gamma-glutamyltransferase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: Increased activity of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.
PMOID: PMO:00003583
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.12
database_cross_reference: HPO:HP:0030948

Skeletal muscle fibrosis
type: Class
subclass of: Abnormal muscle morphology
definition: Excessive formation of fibrous bands of scar tissue in between muscle fibers.
PMOID: PMO:00009587
Subclass_of: Abnormal muscle morphology
Tree Number: T3.17.1.13
database_cross_reference: HPO:HP:0030951

Abnormality of cardiovascular system electrophysiology
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: An anomaly of the electrical conduction physiology of the heart.
PMOID: PMO:00004822
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.9
database_cross_reference: HPO:HP:0030956

Abnormal systemic blood pressure
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: A chronic deviation from normal pressure in the systemic arterial system.
PMOID: PMO:00004764
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.6
database_cross_reference: HPO:HP:0030972

Postexertional malaise
type: Class
subclass of: Fatigue
definition: A subjective feeling of tiredness characterized by a lack of energy and motivation and that is induced by exertion or exercise.
PMOID: PMO:00014059
Subclass_of: Fatigue
Synonym: Exercise-induced fatigue
Synonym: Exercise-induced malaise
Synonym: Postexertional fatigue
Tree Number: T3.23.5.3
database_cross_reference: HPO:HP:0030973

Elevated carcinoembryonic antigen level
type: Class
subclass of: Abnormality of circulating protein level
definition: An increased blood concentration of the carcinoembryonic antigen (CEA). CEA is a member of the immunoglobulin supergene family. The human CEA gene family is clustered on chromosome 19q and comprises 29 genes. CEA is highly expressed in embryonic tissue and in some cancers, and is a widely used tumor marker.
PMOID: PMO:00003961
Subclass_of: Abnormality of circulating protein level
Synonym: Increased plasma CEA
Tree Number: T3.6.12.15
database_cross_reference: HPO:HP:0031029

Elevated carcinoma antigen 125 level
type: Class
subclass of: Abnormality of circulating protein level
definition: An increased blood concentration of carcinoma antigen 125 (CA-125). CA-125, also known as mucin 16, can exhibit increased blood levels in certain types of cancer.
PMOID: PMO:00003962
Subclass_of: Abnormality of circulating protein level
Synonym: Increased plasma CA125
Tree Number: T3.6.12.16
database_cross_reference: HPO:HP:0031030

Abnormal retinol-binding protein level
type: Class
subclass of: Abnormality of circulating protein level
definition: A deviation from normal blood concentration of retinol-binding protein (RBP). The most commonly used indicator of vitamin A status is the serum retinol concentration (retinol is one of the several compounds known as vitamin A). The serum RBP concentration is used as a surrogate measure for serum retinol.
PMOID: PMO:00003949
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.10
database_cross_reference: HPO:HP:0031031

Abnormal insulin like growth factor binding protein acid labile subunit level
type: Class
subclass of: Abnormality of circulating protein level
definition: A deviation from the normal blood concentration of the insulin like growth factor binding protein acid labile subunit (IGFALS; Entrez Gene ID 3483). The acid-labile subunit (IGFALS) acts in the insulin-like growth (IGF) system by binding circulating IGF1 in a ternary complex with binding protein (IGFBP)-3 to prevent IGF1 from crossing the endothelial barrier.
PMOID: PMO:00003942
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.8
database_cross_reference: HPO:HP:0031034

Chronic infection
type: Class
subclass of: Abnormality of immune system physiology
definition: Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.
PMOID: PMO:00008600
Subclass_of: Abnormality of immune system physiology
Synonym: Chronic infection (disorder)
Synonym: Chronic infectious disease
Synonym: Chronic infectious disease (disorder)
Synonym: Chronic infectious disease [Ambiguous]
Synonym: chronic disease infectious
Synonym: chronic infection
Synonym: chronic infections
Synonym: infection chronic
Tree Number: T3.15.2.8
database_cross_reference: CHV:0000016962
database_cross_reference: HPO:HP:0031035
database_cross_reference: MDR:10076201
database_cross_reference: SNMI:DE-00003
database_cross_reference: SNOMEDCT_US:176130006
database_cross_reference: SNOMEDCT_US:177010002
database_cross_reference: SNOMEDCT_US:42017001

Reduced growth-hormone binding protein level
type: Class
subclass of: Abnormality of circulating protein level
definition: A decreased blood concentration of growth hormone binding protein.
PMOID: PMO:00003969
Subclass_of: Abnormality of circulating protein level
Synonym: Decreased plasma GH-binding protein
Tree Number: T3.6.12.22
database_cross_reference: HPO:HP:0031036

Reduced insulin-like factor 3 level
type: Class
subclass of: Abnormality of circulating protein level
definition: Blood concentration of insulin-like factor 3 (ILF3) is below normal limits.
PMOID: PMO:00003970
Subclass_of: Abnormality of circulating protein level
Synonym: Reduced plasma INSL3 level
Tree Number: T3.6.12.23
database_cross_reference: HPO:HP:0031037

Elevated vascular endothelial growth factor level
type: Class
subclass of: Abnormality of circulating hormone level
definition: Increased blood concentration of vascular endothelial growth factor (VEGF).
PMOID: PMO:00006193
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.20
database_cross_reference: HPO:HP:0031052

Impairment of activities of daily living
type: Class
subclass of: Constitutional symptom
definition: Difficulty in performing one or more activities normally performed every day, such as eating, bathing, dressing, grooming, work, homemaking, and leisure.
PMOID: PMO:00014062
Subclass_of: Constitutional symptom
Tree Number: T3.23.8
database_cross_reference: HPO:HP:0031058

Impaired ability to bathe oneself
type: Class
subclass of: Impairment of activities of daily living
definition: This term applies to an individual who requires help to bathe more than one part of the body, get in or out of the tub or shower, or who requires total bathing.
PMOID: PMO:00014063
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.1
database_cross_reference: HPO:HP:0031059

Impaired ability to dress oneself
type: Class
subclass of: Impairment of activities of daily living
definition: This applies to an individual who needs help with dressing or needs to be completely dressed.
PMOID: PMO:00014064
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.2
database_cross_reference: HPO:HP:0031060

Impaired toileting ability
type: Class
subclass of: Impairment of activities of daily living
definition: This term applies to an individual who requires help transferring to the toilet, cleaning self or who uses bedpan or commode.
PMOID: PMO:00014071
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.5
database_cross_reference: HPO:HP:0031061

Impaired transferring ability
type: Class
subclass of: Impairment of activities of daily living
definition: Applies to an individual who needs help in moving from bed to chair or requires a complete transfer.
PMOID: PMO:00014072
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.6
database_cross_reference: HPO:HP:0031062

Impaired feeding ability
type: Class
subclass of: Impairment of activities of daily living
definition: Applies to an individual who needs partial or total help with feeding or requires parenteral feeding.
PMOID: PMO:00014070
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.4
database_cross_reference: HPO:HP:0031063

Impaired continence
type: Class
subclass of: Impairment of activities of daily living
definition: Partial or total incontinence of bowel or bladder.
PMOID: PMO:00014065
Subclass_of: Impairment of activities of daily living
Tree Number: T3.23.8.3
database_cross_reference: HPO:HP:0031064

Abnormal endocrine morphology
type: Class
subclass of: Abnormality of the endocrine system
definition: Any anomaly of the structure of an organ ofthe endocrine system.
PMOID: PMO:00006109
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.1
database_cross_reference: HPO:HP:0031071

Abnormal endocrine physiology
type: Class
subclass of: Abnormality of the endocrine system
definition: Any anomaly of the function of the endocrine system.
PMOID: PMO:00006110
Subclass_of: Abnormality of the endocrine system
Tree Number: T3.12.2
database_cross_reference: HPO:HP:0031072

Abnormal response to endocrine stimulation test
type: Class
subclass of: Abnormal endocrine physiology
definition: An anomalous response to a test that is designed to probe the function of the endocrine system.
PMOID: PMO:00006111
Subclass_of: Abnormal endocrine physiology
Tree Number: T3.12.2.1
database_cross_reference: HPO:HP:0031073

Abnormal response to glucagon stimulation test
type: Class
subclass of: Abnormal endocrine physiology
definition: An anomalous response to the glucagon stimulation test, which like the insulin tolerance test (ITT) stimulates the release of both adrenocorticotropic hormone (ACTH) and growth hormone (GH).
PMOID: PMO:00006120
Subclass_of: Abnormal endocrine physiology
Tree Number: T3.12.2.2
database_cross_reference: HPO:HP:0031080

Abnormal response to human chorionic gonadotrophin stimulation test
type: Class
subclass of: Abnormal endocrine physiology
definition: An anomalous response to intravenous stimulation by human chorionic gonadotrophin. Stimulation with hCG stimulates testicular Leydig cells to secrete androgens via the Leydig hormone receptors.
PMOID: PMO:00006124
Subclass_of: Abnormal endocrine physiology
Synonym: Abnormal response to hCG stimulation test
Tree Number: T3.12.2.3
database_cross_reference: HPO:HP:0031083

Decreased prealbumin level
type: Class
subclass of: Abnormality of circulating protein level
definition: A reduced concentration of prealbumin in the blood. Prealbumin, also known as transthyretin, has a half-life in plasma of about 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status.
PMOID: PMO:00003959
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.13
database_cross_reference: HPO:HP:0031085

Absent pubertal growth spurt
type: Class
subclass of: Growth delay
definition: The abrupt and transient increase in the annual growth rate normally observed in adolescent individuals does not occur.
PMOID: PMO:00014173
Subclass_of: Growth delay
Synonym: Absent adolescent growth spurt
Tree Number: T3.24.4.1
database_cross_reference: HPO:HP:0031087

Abnormal breast morphology
type: Class
subclass of: Abnormality of the breast
definition: Any anomaly of the structure of the breast.
PMOID: PMO:00004416
Subclass_of: Abnormality of the breast
Tree Number: T3.8.1
database_cross_reference: HPO:HP:0031093

Abnormal breast physiology
type: Class
subclass of: Abnormality of the breast
definition: Any anomaly of the function of the breast.
PMOID: PMO:00004438
Subclass_of: Abnormality of the breast
Tree Number: T3.8.2
database_cross_reference: HPO:HP:0031094

Abnormal circulating inhibin level
type: Class
subclass of: Abnormality of circulating hormone level
definition: Any deviation from the normal concentration of iInhibins, which are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. Inhibins suppress the secretion of pituitary follicle-stimulating hormone.
PMOID: PMO:00006157
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.6
database_cross_reference: HPO:HP:0031099

Abnormal antimullerian hormone level
type: Class
subclass of: Abnormality of circulating hormone level
definition: Any deviation from the normal range of the antimullerian hormone, a peptide produced by the granulosa cells of follicles. Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is produced by the granulosa cells of small antral follicles of the ovary. AMH has an inhibiting role in the ovary, contributing to follicular arrest. AMH levels in women are low until the age of 8, rise rapidly until puberty and decline steadily from the age of 25 until menopause, when AMH production ceases.
PMOID: PMO:00006130
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.2
database_cross_reference: HPO:HP:0031101

Agalactia
type: Class
subclass of: Abnormal breast physiology
definition: Failure of secretion of milk following childbirth associated with an inability to breastfeed an infant.
PMOID: PMO:00004439
Subclass_of: Abnormal breast physiology
Synonym: Absence of lactation
Synonym: Agalactorrhea
Synonym: Agalactosis
Synonym: Failed lactation
Synonym: Failure of lactation
Synonym: Failure of lactation (disorder)
Synonym: Failure of lactation - delivered
Synonym: Failure of lactation - delivered (disorder)
Synonym: Failure of lactation NOS
Synonym: Failure of lactation NOS (disorder)
Tree Number: T3.8.2.1
database_cross_reference: CHV:0000017190
database_cross_reference: DO:DOID:1402
database_cross_reference: HPO:HP:0031109
database_cross_reference: ICD10:O92.3
database_cross_reference: ICD10AM:O92.3
database_cross_reference: ICD10CM:O92.3
database_cross_reference: ICD9CM:676.4
database_cross_reference: ICD9CM:676.40
database_cross_reference: ICPC2P:W19012
database_cross_reference: MDR:10016125
database_cross_reference: MDR:10016154
database_cross_reference: MDR:10016157
database_cross_reference: MEDCIN:34349
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:676.4
database_cross_reference: MTHICD9:676.40
database_cross_reference: NCI:C114409
database_cross_reference: NCI_NICHD:C114409
database_cross_reference: RCD:L464.
database_cross_reference: RCD:L4640
database_cross_reference: RCD:L464z
database_cross_reference: SNM:F-31925
database_cross_reference: SNMI:D8-41240
database_cross_reference: SNOMEDCT_US:156287009
database_cross_reference: SNOMEDCT_US:200432009
database_cross_reference: SNOMEDCT_US:200437003
database_cross_reference: SNOMEDCT_US:6995000
database_cross_reference: SNOMEDCT_VET:6995000

Twin-to-twin transfusion
type: Class
subclass of: Abnormality of prenatal development or birth
definition: As a result of sharing a single placenta, the blood supplies of monochorionic twin fetuses can become connected, so that they share blood circulation: although each fetus uses its own portion of the placenta, the connecting blood vessels within the placenta allow blood to pass from one twin to the other.Depending on the number, type and direction of the interconnecting blood vessels (anastomoses), blood can be transferred disproportionately from one twin (the donor) to the other (the recipient). This state of transfusion causes the donor twin to have decreased blood volume, retarding the donor's development and growth. The blood volume of the recipient twin is increased, which can strain the fetus's heart and eventually lead to heart failure.
PMOID: PMO:00004414
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.13
database_cross_reference: HPO:HP:0031110

Abnormal B-type natriuretic peptide level
type: Class
subclass of: Abnormality of circulating protein level
definition: A deviation from the normal circulating concentration of B-type natriuretic peptide (BNP).
PMOID: PMO:00003924
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.3
database_cross_reference: HPO:HP:0031138

Postterm pregnancy
type: Class
subclass of: Abnormality of prenatal development or birth
definition: A pregnancy that extends to 42 weeks of gestation or beyond.
PMOID: PMO:00004380
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.9
database_cross_reference: HPO:HP:0031169

Female fetal virilization
type: Class
subclass of: Abnormality of prenatal development or birth
definition: Fetal masculinization of female external genitalia.
PMOID: PMO:00004351
Subclass_of: Abnormality of prenatal development or birth
Tree Number: T3.7.4
database_cross_reference: HPO:HP:0031170

Fixed head retroflexion
type: Class
subclass of: Abnormality of the head
definition: Head is bent in the posterior direction in a permanent fashion.
PMOID: PMO:00002472
Subclass_of: Abnormality of the head
Tree Number: T3.4.1.5
database_cross_reference: HPO:HP:0031178

Abnormality of circulating pregnenolone level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An abnormality of the concentration of pregnenolone in the blood.
PMOID: PMO:00006188
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.16
database_cross_reference: HPO:HP:0031187

Reduced lysosomal acid lipase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: Reduction in the activity of lysosomal acid lipase (LAL) in the blood. Lysosomal lipase activity is measured. LAL hydrolyzes cholesteryl esters derived from cell internalization of plasma lipoproteins.
PMOID: PMO:00003587
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Reduced leukocyte acid lipase activity
Tree Number: T3.6.3.16
database_cross_reference: HPO:HP:0031205

Increased pituitary glycoprotein alpha subunit level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An increased concentration of circulating alpha polypeptide of glycoprotein hormones (Entrez Gene 1081). This alpha subunit is common to luteinizing hormone (LH) , follicle stimulating hormone (FSH) , thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), which are glycoprotein hormones composed of an identical alpha subunit together with a beta subunit that confers biological specificity. The alpha subunit is used as a marker for tumors that produce these hormones.
PMOID: PMO:00006197
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.23
database_cross_reference: HPO:HP:0031208

Decreased lipoprotein lipase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: Reduction in the activity of lipoprotein lipase in the blood.
PMOID: PMO:00003581
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.10
database_cross_reference: HPO:HP:0031209

Abnormal circulating progesterone level
type: Class
subclass of: Abnormality of circulating hormone level
PMOID: PMO:00006162
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.8
database_cross_reference: HPO:HP:0031212

Decreased circulating dehydroepiandrosterone level
type: Class
subclass of: Abnormality of circulating hormone level
PMOID: PMO:00006191
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.18
database_cross_reference: HPO:HP:0031214

Decreased circulating dehydroepiandrosterone-sulfate level
type: Class
subclass of: Abnormality of circulating hormone level
definition: A reduced concentration of dehydroepiandrosterone-sulfate in the blood.
PMOID: PMO:00006192
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.19
database_cross_reference: HPO:HP:0031215

Hot flashes
type: Class
subclass of: Constitutional symptom
definition: Sudden feelings of warmth that are generally most pronounced over the face, neck and chest.
PMOID: PMO:00014061
Subclass_of: Constitutional symptom
Synonym: Climacteric flushing
Synonym: Climacteric flushing (disorder)
Synonym: FLASH HOT
Synonym: FLUSH HOT
Synonym: Feeling of hot flushes
Synonym: Flash hot
Synonym: Flashes, Hot
Synonym: Flush hot
Synonym: HOT FLASH
Synonym: HOT FLASHES
Tree Number: T3.23.7
database_cross_reference: BI:BI00388
database_cross_reference: CCPSS:1006550
database_cross_reference: CHV:0000006287
database_cross_reference: CHV:0000042193
database_cross_reference: COSTAR:391
database_cross_reference: COSTAR:U000406
database_cross_reference: CSP:5004-0040
database_cross_reference: CST:VASODILAT
database_cross_reference: HPO:HP:0031217
database_cross_reference: ICPC2P:K29021
database_cross_reference: ICPC2P:X11021
database_cross_reference: MDR:10016350
database_cross_reference: MDR:10016752
database_cross_reference: MDR:10016820
database_cross_reference: MDR:10020407
database_cross_reference: MDR:10020408
database_cross_reference: MDR:10020411
database_cross_reference: MDR:10020413
database_cross_reference: MDR:10020417
database_cross_reference: MDR:10027301
database_cross_reference: MDR:10027311
database_cross_reference: MDR:10060800
database_cross_reference: MEDCIN:1064
database_cross_reference: MEDLINEPLUS:62
database_cross_reference: MSH:D019584
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3109
database_cross_reference: NCI_CTCAE:E13781
database_cross_reference: NCI_FDA:2153
database_cross_reference: NCI_NCI-GLOSS:CDR0000256567
database_cross_reference: NDFRT:N0000003943
database_cross_reference: PDQ:CDR0000042906
database_cross_reference: RCD:K5A20
database_cross_reference: RCD:XaBYP
database_cross_reference: SNM:F-30490
database_cross_reference: SNMI:F-81870
database_cross_reference: SNOMEDCT_US:198436008
database_cross_reference: SNOMEDCT_US:389318003
database_cross_reference: SNOMEDCT_US:390053008
database_cross_reference: SNOMEDCT_US:427368007
database_cross_reference: SNOMEDCT_US:67443009

Inappropriate antidiuretic hormone secretion
type: Class
subclass of: Abnormal endocrine physiology
definition: A state of increased circulating antidiuretic hormone despite hyponatremia and hypo-osmolality with normal or increased plasma volume.
PMOID: PMO:00006125
Subclass_of: Abnormal endocrine physiology
Synonym: ADH INAPPROPRIATE
Synonym: ADH INAPPROPRIATE SECRETION
Synonym: ADH Syndrome, Inappropriate
Synonym: ADH inappropriate
Synonym: ADH inappropriate secretion
Synonym: ANTIDIURETIC HORMONE INAPPROPRIATE SECRET
Synonym: Antidiuretic Hormone, Inappropriate Secretion
Synonym: INAPPROPRIATE ADH
Synonym: INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE
Synonym: INAPPROPRIATE VASOPRESSIN SECRET SYNDROME
Tree Number: T3.12.2.4
database_cross_reference: AOD:0000005977
database_cross_reference: CCPSS:0019261
database_cross_reference: CHV:0000006634
database_cross_reference: COSTAR:NOCODE
database_cross_reference: COSTAR:U000576
database_cross_reference: CST:ADH INAPPROP
database_cross_reference: CST:METSIADH
database_cross_reference: DO:DOID:3401
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000930
database_cross_reference: HPO:HP:0031218
database_cross_reference: ICD10:E22.2
database_cross_reference: ICD10AM:E22.2
database_cross_reference: ICD10CM:E22.2
database_cross_reference: MDR:10001270
database_cross_reference: MDR:10001271
database_cross_reference: MDR:10021585
database_cross_reference: MDR:10021586
database_cross_reference: MDR:10021587
database_cross_reference: MDR:10021598
database_cross_reference: MDR:10040626
database_cross_reference: MDR:10042818
database_cross_reference: MDR:10042828
database_cross_reference: MDR:10053198
database_cross_reference: MDR:10071644
database_cross_reference: MEDCIN:30590
database_cross_reference: MSH:D007177
database_cross_reference: MTHICD9:253.6
database_cross_reference: NCI:C3988
database_cross_reference: NCI_NICHD:C3988
database_cross_reference: NDFRT:N0000001674
database_cross_reference: OMIM:MTHU016053
database_cross_reference: RCD:C1360
database_cross_reference: SNM:D-2102
database_cross_reference: SNMI:DB-13200
database_cross_reference: SNOMEDCT_US:389983008
database_cross_reference: SNOMEDCT_US:55004003

Increased circulating thyroxine-binding globulin level
type: Class
subclass of: Abnormality of circulating protein level
definition: An elevated concentration of thyroxine-binding globulin (TBG) in the blood.
PMOID: PMO:00003968
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.21
database_cross_reference: HPO:HP:0031222

Shock
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury.
PMOID: PMO:00004953
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: Acute circulatory failure
Synonym: Acute peripheral circulatory failure
Synonym: CARDIOVASCULAR COLLAPSE
Synonym: CIRCULATORY COLLAPSE
Synonym: CIRCULATORY FAILURE
Synonym: CIRCULATORY FAILURE ACUTE
Synonym: COLLAPSE CARDIOVASCULAR
Synonym: COLLAPSE CIRCULATORY
Synonym: COLLAPSE PERIPHERAL CIRCULATORY
Synonym: COLLAPSE PERIPHERAL VASCULAR
Tree Number: T3.9.3.14
database_cross_reference: CCPSS:0034105
database_cross_reference: CCPSS:0037429
database_cross_reference: CHV:0000011301
database_cross_reference: CHV:0000039014
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1583-6527
database_cross_reference: CST:CVSHOCK
database_cross_reference: CST:SHOCK
database_cross_reference: DXP:U003549
database_cross_reference: HPO:HP:0031273
database_cross_reference: ICD10:R57.9
database_cross_reference: ICD10AM:R57.9
database_cross_reference: ICD10CM:R57.9
database_cross_reference: ICD9CM:785.50
database_cross_reference: LCH:U004299
database_cross_reference: LCH_NW:sh85121705
database_cross_reference: LNC:LA7473-7
database_cross_reference: MDR:10000692
database_cross_reference: MDR:10007647
database_cross_reference: MDR:10009192
database_cross_reference: MDR:10009195
database_cross_reference: MDR:10009908
database_cross_reference: MDR:10009909
database_cross_reference: MDR:10009910
database_cross_reference: MDR:10009914
database_cross_reference: MDR:10009915
database_cross_reference: MDR:10009917
database_cross_reference: MDR:10016144
database_cross_reference: MDR:10016161
database_cross_reference: MDR:10034567
database_cross_reference: MDR:10040560
database_cross_reference: MDR:10040564
database_cross_reference: MDR:10040583
database_cross_reference: MDR:10040585
database_cross_reference: MDR:10047052
database_cross_reference: MEDCIN:33395
database_cross_reference: MEDLINEPLUS:5717
database_cross_reference: MSH:D012769
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:785.50
database_cross_reference: NCI:C35016
database_cross_reference: NCI_FDA:2072
database_cross_reference: NCI_NICHD:C35016
database_cross_reference: NDFRT:N0000002728
database_cross_reference: OMIM:MTHU032133
database_cross_reference: PSY:47200
database_cross_reference: RCD:R0550
database_cross_reference: RCD:XM00r
database_cross_reference: RCD:XM1C7
database_cross_reference: RCDSY:R0550
database_cross_reference: SNM:F-70010
database_cross_reference: SNMI:D3-80600
database_cross_reference: SNOMEDCT_US:158354004
database_cross_reference: SNOMEDCT_US:207026006
database_cross_reference: SNOMEDCT_US:267302008
database_cross_reference: SNOMEDCT_US:274729009
database_cross_reference: SNOMEDCT_US:27942005
database_cross_reference: SNOMEDCT_VET:27942005

Abnormal cardiomyocyte morphology
type: Class
subclass of: Abnormal cell morphology
definition: Any structural anomaly of cardiomyocytes, which are terminally differentiated muscle cells in the heart that are interconnected end to end by gap junctions, which allows coordinated contraction of heart tissue.
PMOID: PMO:00000871
Subclass_of: Abnormal cell morphology
Synonym: Abnormal cardiac muscle cell morphology
Tree Number: T3.1.1.2
database_cross_reference: HPO:HP:0031331

Abnormal lysosomal morphology
type: Class
subclass of: Abnormal cell morphology
definition: A structural anomaly of lysosomes, membrane-enclosed organelles that contain an array of enzymes capable of catabolizing proteins, nucleic acids, carbohydrates, and lipids.
PMOID: PMO:00000887
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.5
database_cross_reference: HPO:HP:0031340

Chest tightness
type: Class
subclass of: Constitutional symptom
definition: An unpleasant sensation of tightness or pressure in the chest.
PMOID: PMO:00014053
Subclass_of: Constitutional symptom
Synonym: CHEST SYMPTOM TIGHTNESS
Synonym: CHEST TIGHTNESS OF
Synonym: CONSTRICTED CHEST
Synonym: CONSTRICTION CHEST
Synonym: Chest tightness of
Synonym: Constriction chest
Synonym: Feeling of chest tightness
Synonym: Feels Tightness in the Chest
Synonym: I feel tightness in my chest
Synonym: TIGHTNESS IN CHEST
Tree Number: T3.23.3
database_cross_reference: CCPSS:1017168
database_cross_reference: CHV:0000022913
database_cross_reference: CST:PAIN CHEST
database_cross_reference: DXP:U000846
database_cross_reference: HPO:HP:0031352
database_cross_reference: ICPC2P:A11004
database_cross_reference: MDR:10008492
database_cross_reference: MDR:10008493
database_cross_reference: MDR:10010780
database_cross_reference: MDR:10043854
database_cross_reference: MDR:10043858
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:786.59
database_cross_reference: NCI:C106402
database_cross_reference: NCI:FACT-L
database_cross_reference: RCD:R0658
database_cross_reference: RCD:XM08A
database_cross_reference: RCDSY:R0658
database_cross_reference: SNM:F-71560
database_cross_reference: SNMI:F-37160
database_cross_reference: SNOMEDCT_US:158401001
database_cross_reference: SNOMEDCT_US:207087000
database_cross_reference: SNOMEDCT_US:23924001

Abnormal cell proliferation
type: Class
subclass of: Abnormal cellular physiology
definition: Any abnormality in the multiplication or reproduction of cells, which may result in the expansion of a cell population.
PMOID: PMO:00003477
Subclass_of: Abnormal cellular physiology
Tree Number: T3.6.2.1
database_cross_reference: HPO:HP:0031377

Abnormal lymphocyte surface marker expression
type: Class
subclass of: Abnormality of immune system physiology
definition: Abnormal amount of a protein that is normally present on the cell surface of lymphocytes.
PMOID: PMO:00008521
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.3
database_cross_reference: HPO:HP:0031383

Abnormal MHC II surface expression
type: Class
subclass of: Abnormality of immune system physiology
definition: A deviation from the normal level of major histocompatibility complex class II molecules expressed at the cell surface.
PMOID: PMO:00008524
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.4
database_cross_reference: HPO:HP:0031389

Impaired antigen-specific response
type: Class
subclass of: Abnormality of immune system physiology
definition: An impaired immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
PMOID: PMO:00008623
Subclass_of: Abnormality of immune system physiology
Synonym: Impaired adaptive immune response
Tree Number: T3.15.2.12
database_cross_reference: HPO:HP:0031404

Abnormal lymphocyte physiology
type: Class
subclass of: Abnormality of immune system physiology
definition: Any anomaly of lymphocyte function.
PMOID: PMO:00008446
Subclass_of: Abnormality of immune system physiology
Tree Number: T3.15.2.2
database_cross_reference: HPO:HP:0031409

Abnormal chromosome morphology
type: Class
subclass of: Abnormal cell morphology
definition: Any structural anomaly of a chromosome, which is a thread like molecule consisting of DNA and proteins (chromatin) that contains DNA sequences for genes and other genetic elements in linear order.
PMOID: PMO:00000882
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.3
database_cross_reference: HPO:HP:0031411

Abnormal nasal mucus secretion
type: Class
subclass of: Functional respiratory abnormality
definition: Any deviation from the normal quantity of secretion of nasal mucus, a thick viscous liquid produced by the mucous membranes of the nose.
PMOID: PMO:00011578
Subclass_of: Functional respiratory abnormality
Tree Number: T3.19.2.5
database_cross_reference: HPO:HP:0031416

Reduced sex -hormone binding protein level
type: Class
subclass of: Abnormality of circulating protein level
definition: A decreased concentration of sex-hormone binding protein in the circulation.
PMOID: PMO:00003972
Subclass_of: Abnormality of circulating protein level
Synonym: Reduced androgen-binding protein level
Tree Number: T3.6.12.25
database_cross_reference: HPO:HP:0031419

Abnormal circulating beta-C-terminal telopeptide level
type: Class
subclass of: Abnormality of circulating protein level
definition: A deviation from the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation, a marker of the rate of bone turnover.
PMOID: PMO:00003934
Subclass_of: Abnormality of circulating protein level
Synonym: Abnormal circulating beta-CTx level
Synonym: Abnormal circulating beta-CrossLaps level
Tree Number: T3.6.12.5
database_cross_reference: HPO:HP:0031424

Abnormal circulating osteocalcin level
type: Class
subclass of: Abnormality of circulating hormone level
definition: A deviation from the normal concentration of osteocalcin in the blood circulation.
PMOID: PMO:00006159
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.7
database_cross_reference: HPO:HP:0031427

Abnormal speech prosody
type: Class
subclass of: Abnormality of the voice
definition: An anomaly of the expressive patterns of speech that involve intonation, stress pattern, loudness variations, pausing, articulatory force, and rhythm.
PMOID: PMO:00014025
Subclass_of: Abnormality of the voice
Tree Number: T3.22.2
database_cross_reference: HPO:HP:0031434

Monotonic speech
type: Class
subclass of: Abnormal speech prosody
definition: A speech pattern characterized by abnormally reduced or lacking variability of the pitch of the voice.
PMOID: PMO:00014027
Subclass_of: Abnormal speech prosody
Tree Number: T3.22.2.2
database_cross_reference: HPO:HP:0031435

Increased pitch variability of speech
type: Class
subclass of: Abnormal speech prosody
definition: A speech pattern characterized by abnormally elevated variability of the pitch of the voice.
PMOID: PMO:00014026
Subclass_of: Abnormal speech prosody
Tree Number: T3.22.2.1
database_cross_reference: HPO:HP:0031436

Pregnancy exposure
type: Class
subclass of: Prenatal maternal abnormality
definition: Exposure of pregnant women to toxins from any source, such as environmental toxins or chemicals, that may potentially cause problems such as miscarriage, preterm delivery, low birth weight, and, in some cases, developmental delays in infants.
PMOID: PMO:00004403
Subclass_of: Prenatal maternal abnormality
Synonym: Exposure during pregnancy
Tree Number: T3.7.11.11
database_cross_reference: HPO:HP:0031437

Lower extremity subcutanous fat hypertrophy
type: Class
subclass of: Abnormal adipose tissue morphology
definition: An abnormal increase in the amount of subcutaneous fat in the legs.
PMOID: PMO:00001294
Subclass_of: Abnormal adipose tissue morphology
Tree Number: T3.3.1.8
database_cross_reference: HPO:HP:0031451

Ectopic pregnancy
type: Class
subclass of: Prenatal maternal abnormality
definition: A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube).
PMOID: PMO:00004391
Subclass_of: Prenatal maternal abnormality
Synonym: 8-02 ECTOPIC PREGNANCIES
Synonym: ECTOPIC PREGN
Synonym: ECTOPIC PREGNANCIES
Synonym: ECTOPIC PREGNANCY
Synonym: EP - Ectopic pregnancy
Synonym: Eccyesis
Synonym: Ectopic Pregnancies
Synonym: Ectopic Pregnancy
Synonym: Ectopic pregnancy (disorder)
Synonym: Ectopic pregnancy NOS
Tree Number: T3.7.11.2
database_cross_reference: CCPSS:0058085
database_cross_reference: CCPSS:1017912
database_cross_reference: CHV:0000010065
database_cross_reference: COSTAR:U000217
database_cross_reference: CSP:2403-8709
database_cross_reference: CST:PREGN DIS
database_cross_reference: DO:DOID:0060329
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001067
database_cross_reference: HPO:HP:0031456
database_cross_reference: ICD10:O00
database_cross_reference: ICD10:O00.9
database_cross_reference: ICD10AM:O00
database_cross_reference: ICD10AM:O00.9
database_cross_reference: ICD10CM:O00
database_cross_reference: ICD10CM:O00.9
database_cross_reference: ICD10CM:O00.90
database_cross_reference: ICD9CM:633
database_cross_reference: ICD9CM:633.9
database_cross_reference: ICPC2EENG:W80
database_cross_reference: ICPC2P:W80001
database_cross_reference: LCH:U003806
database_cross_reference: LCH_NW:sh85106288
database_cross_reference: LNC:MTHU015326
database_cross_reference: MDR:10014166
database_cross_reference: MDR:10014169
database_cross_reference: MDR:10015765
database_cross_reference: MDR:10015865
database_cross_reference: MDR:10036559
database_cross_reference: MDR:10045857
database_cross_reference: MDR:10072039
database_cross_reference: MEDCIN:30600
database_cross_reference: MEDLINEPLUS:5811
database_cross_reference: MSH:D011271
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34945
database_cross_reference: NCI_FDA:1819
database_cross_reference: NCI_GAIA:C34945
database_cross_reference: NCI_NCI-GLOSS:CDR0000666673
database_cross_reference: NCI_NCI-GLOSS:CDR0000666674
database_cross_reference: NCI_NICHD:C34945
database_cross_reference: NDFRT:N0000002486
database_cross_reference: RCD:L03..
database_cross_reference: RCD:L03z.
database_cross_reference: SNM:F-31100
database_cross_reference: SNMI:D8-02000
database_cross_reference: SNOMEDCT_US:156080003
database_cross_reference: SNOMEDCT_US:156083001
database_cross_reference: SNOMEDCT_US:198630007
database_cross_reference: SNOMEDCT_US:34801009

Soft tissue neoplasm
type: Class
subclass of: Neoplasm by anatomical site
definition: A tumor (abnormal growth of tissue) that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms.
PMOID: PMO:00014265
Subclass_of: Neoplasm by anatomical site
Synonym: Neoplasm of Soft Tissue
Synonym: Neoplasm of soft tissue
Synonym: Neoplasm of soft tissue (disorder)
Synonym: Neoplasm of soft tissues
Synonym: Neoplasm of soft tissues (disorder)
Synonym: Neoplasm of the Soft Tissue
Synonym: Neoplasm, Soft Tissue
Synonym: Neoplasms, Soft Tissue
Synonym: SOFT TISSUE NEOPL
Synonym: SOFT TISSUE TUMOR
Tree Number: T3.25.1.12
database_cross_reference: CCPSS:0054044
database_cross_reference: CHV:0000011508
database_cross_reference: DO:DOID:0060123
database_cross_reference: HPO:HP:0031459
database_cross_reference: LCH_NW:sh91000905
database_cross_reference: MDR:10068771
database_cross_reference: MEDCIN:90412
database_cross_reference: MSH:D012983
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3377
database_cross_reference: NCI_CTEP-SDC:10061271
database_cross_reference: NDFRT:N0000002780
database_cross_reference: RCD:Xa0Pj
database_cross_reference: RCDAE:Xa0Pj
database_cross_reference: SNOMEDCT_US:126600002
database_cross_reference: SNOMEDCT_US:387837005

Musculotendinous retraction
type: Class
subclass of: Abnormality of connective tissue
definition: Abnormal reduction in length of a tendon which tends to pull (retract) the attached muscle tissue with shortening of the muscle fibers often accompanied by atrophy and fatty degeneration of the affected muscle tissue.
PMOID: PMO:00001362
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.9
database_cross_reference: HPO:HP:0031462

Abnormal buccal mucosa cell morphology
type: Class
subclass of: Abnormal cell morphology
definition: Any structural anomaly of the cells of the mucosa of the oral cavity in the region of the cheek (buccal mucosa cells).
PMOID: PMO:00000869
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.1
database_cross_reference: HPO:HP:0031476

Epithelial neoplasm
type: Class
subclass of: Neoplasm by histology
definition: A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas [NCIT:C3709].
PMOID: PMO:00014307
Subclass_of: Neoplasm by histology
Synonym: 801-804 EPITHELIAL NEOPLASMS, NOS
Synonym: EPITHELIAL NEOPL
Synonym: EPITHELIAL NEOPLASMS, NOS
Synonym: Epithelial Neoplasm
Synonym: Epithelial Neoplasms
Synonym: Epithelial Neoplasms, NOS
Synonym: Epithelial neoplasm (morphologic abnormality)
Synonym: Epithelial neoplasms NOS
Synonym: Epithelial tumor
Synonym: Epithelial tumor (qualifier value)
Tree Number: T3.25.2.2
database_cross_reference: AOD:0000004523
database_cross_reference: AOD:0000023017
database_cross_reference: CHV:0000020733
database_cross_reference: CSP:2000-5801
database_cross_reference: HPO:HP:0031492
database_cross_reference: ICPC2P:R85007
database_cross_reference: ICPC2P:R92002
database_cross_reference: MDR:10015105
database_cross_reference: MSH:D009375
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3709
database_cross_reference: OMIM:MTHU013710
database_cross_reference: RCD:BB1..
database_cross_reference: RCD:BB1z.
database_cross_reference: RCD:X77mu
database_cross_reference: RCDAE:X77mu
database_cross_reference: RCDSY:BB1..
database_cross_reference: RCDSY:BB1z.
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:M-80100
database_cross_reference: SNOMEDCT_US:118285006
database_cross_reference: SNOMEDCT_US:134207000
database_cross_reference: SNOMEDCT_US:188083002
database_cross_reference: SNOMEDCT_US:189546004
database_cross_reference: SNOMEDCT_US:189559007
database_cross_reference: SNOMEDCT_VET:45741000009101

Abdominal mass
type: Class
subclass of: Abnormality of abdomen morphology
definition: An abnormal enlargement or swelling in the abdomen.
PMOID: PMO:00005302
Subclass_of: Abnormality of abdomen morphology
Tree Number: T3.10.1.2
database_cross_reference: HPO:HP:0031500

Pelvic mass
type: Class
subclass of: Abnormality of abdomen morphology
definition: An abnormal enlargement or swelling in the pelvic region.
PMOID: PMO:00005308
Subclass_of: Abnormality of abdomen morphology
Tree Number: T3.10.1.5
database_cross_reference: HPO:HP:0031501

Groin pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the groin region.
PMOID: PMO:00014096
Subclass_of: Pain
Synonym: GROIN PAIN
Synonym: Groin pain (finding)
Synonym: INGUINAL PAIN
Synonym: Inguinal pain
Synonym: Inguinal pain (finding)
Synonym: Inguinal region painful
Synonym: Inguinodynia
Synonym: PAIN GROIN
Synonym: Pain groin
Synonym: Pain;groin
Tree Number: T3.23.10.17
database_cross_reference: CCPSS:1011096
database_cross_reference: CHV:0000024270
database_cross_reference: CST:PAIN PELVIC
database_cross_reference: DXP:U001744
database_cross_reference: HPO:HP:0031520
database_cross_reference: ICPC2P:L14002
database_cross_reference: MDR:10018735
database_cross_reference: MDR:10033403
database_cross_reference: MDR:10077184
database_cross_reference: MEDCIN:563
database_cross_reference: RCD:R090B
database_cross_reference: RCD:XM091
database_cross_reference: RCD:Xa84t
database_cross_reference: RCDSY:R090B
database_cross_reference: SNMI:F-182A0
database_cross_reference: SNOMEDCT_US:102570003
database_cross_reference: SNOMEDCT_US:207217001
database_cross_reference: SNOMEDCT_US:271856002
database_cross_reference: SNOMEDCT_VET:102570003

Abnormal flow cytometry test rest
type: Class
subclass of: Abnormal cellular phenotype
definition: Any abnormal result of flow cytometry, a method that suspends cells in a stream of fluid and passes them through an electronic detection apparatus in order to assess cell count or measure biomarkers or surface molecules.
PMOID: PMO:00000895
Subclass_of: Abnormal cellular phenotype
Tree Number: T3.1.2
database_cross_reference: HPO:HP:0031550

Reduced cell surface marker level
type: Class
subclass of: Abnormal flow cytometry test rest
definition: Reduced level of a protein that is normally present on the cell surface as assessed by flow cytometry.
PMOID: PMO:00000896
Subclass_of: Abnormal flow cytometry test rest
Tree Number: T3.1.2.1
database_cross_reference: HPO:HP:0031551

Asthenopia
type: Class
subclass of: Abnormal eye physiology
definition: Eye strain, i.e., a feeling of fatigue or discomfort of the eyes related to 'overuse' of the eyes in activities such as reading or working at the computer and often accompanied by lacrimation or headache.
PMOID: PMO:00007437
Subclass_of: Abnormal eye physiology
Synonym: ASTHENOPIA
Synonym: ASTHENOPIA, ACCOMMODATIVE
Synonym: Accommodative asthenopia
Synonym: Accommodative asthenopia (finding)
Synonym: Accommodative strain
Synonym: Accommodative strain (disorder)
Synonym: Asthenopia [Disease/Finding]
Synonym: Eye Fatigue
Synonym: Eye Strain
Synonym: Eye strain
Tree Number: T3.13.2.9
database_cross_reference: CHV:0000001540
database_cross_reference: COSTAR:079
database_cross_reference: COSTAR:NOCODE
database_cross_reference: DO:DOID:10141
database_cross_reference: DXP:U000272
database_cross_reference: HPO:HP:0031590
database_cross_reference: ICD10CM:H53.14
database_cross_reference: ICPC2P:F05025
database_cross_reference: ICPC2P:F29001
database_cross_reference: ICPC2P:F29004
database_cross_reference: LCH:U000404
database_cross_reference: LCH:U005181
database_cross_reference: LCH_NW:sh85008857
database_cross_reference: MDR:10003552
database_cross_reference: MDR:10015969
database_cross_reference: MDR:10043887
database_cross_reference: MDR:10043888
database_cross_reference: MDR:10049755
database_cross_reference: MEDCIN:134
database_cross_reference: MEDCIN:2057
database_cross_reference: MEDCIN:30757
database_cross_reference: MSH:D001248
database_cross_reference: MTHICD9:368.13
database_cross_reference: NDFRT:N0000000497
database_cross_reference: RCD:F4815
database_cross_reference: RCD:F4816
database_cross_reference: SNM:F-X0810
database_cross_reference: SNM:F-X2780
database_cross_reference: SNMI:F-F0654
database_cross_reference: SNMI:F-F1764
database_cross_reference: SNOMEDCT_US:193645002
database_cross_reference: SNOMEDCT_US:46640001
database_cross_reference: SNOMEDCT_US:70323002

Abnormal mucociliary clearance
type: Class
subclass of: Functional respiratory abnormality
definition: An anomaly in the system of mucociliary transport, which functions to transport the mucous layer lining the respiratory epithelium by ciliary beating.
PMOID: PMO:00011576
Subclass_of: Functional respiratory abnormality
Synonym: Abnormal mucociliary transport
Tree Number: T3.19.2.4
database_cross_reference: HPO:HP:0031602

Pelvic organ prolapse
type: Class
subclass of: Abnormality of abdomen morphology
definition: Weakness in the supporting structures of the pelvic floor allowing the pelvic viscera to descend or one or more of the pelvic organs drop from their normal position.
PMOID: PMO:00005309
Subclass_of: Abnormality of abdomen morphology
Synonym: Organ Prolapse, Pelvic
Synonym: Organ Prolapses, Pelvic
Synonym: Pelvic Organ Prolapse
Synonym: Pelvic Organ Prolapse [Disease/Finding]
Synonym: Pelvic Organ Prolapses
Synonym: Prolapse, Pelvic Organ
Synonym: Prolapse, Urogenital
Synonym: Prolapses, Pelvic Organ
Synonym: Prolapses, Urogenital
Synonym: Urogenital Prolapse
Tree Number: T3.10.1.6
database_cross_reference: HPO:HP:0031607
database_cross_reference: MDR:10048670
database_cross_reference: MSH:D056887
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000181182

Abnormal heart valve physiology
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: Any functional abnormality of a cardiac valve.
PMOID: PMO:00004747
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.5
database_cross_reference: HPO:HP:0031653

Abnormal heart sound
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: Any abnormal noise generated by the beating heart.
PMOID: PMO:00004731
Subclass_of: Abnormality of cardiovascular system physiology
Tree Number: T3.9.3.4
database_cross_reference: HPO:HP:0031657

Abnormal stool composition
type: Class
subclass of: Abnormality of digestive system morphology
PMOID: PMO:00005314
Subclass_of: Abnormality of digestive system morphology
Synonym: Abnormal faeces composition
Synonym: Abnormal feces composition
Tree Number: T3.10.2.1
database_cross_reference: HPO:HP:0031685

Opportunistic infection
type: Class
subclass of: Abnormality of immune system physiology
definition: An infection that is caused by a pathogen that would generally not be able to cause an infection in a host with a normal immune system. Such pathogens take advantage of the opportunity, so to speak, that is provided by a weakened immune system.
PMOID: PMO:00008626
Subclass_of: Abnormality of immune system physiology
Synonym: Infection, Opportunistic
Synonym: Infections, Opportunistic
Synonym: OI
Synonym: OIs
Synonym: OPPORTUNISTIC INFECT
Synonym: OPPORTUNISTIC INFECTION
Synonym: Opportunistic Infection
Synonym: Opportunistic Infections
Synonym: Opportunistic Infections [Disease/Finding]
Synonym: Opportunistic infections
Tree Number: T3.15.2.13
database_cross_reference: AOD:0000004784
database_cross_reference: CCPSS:0054516
database_cross_reference: CHV:0000008975
database_cross_reference: CSP:0715-7200
database_cross_reference: HPO:HP:0031690
database_cross_reference: LCH:U003362
database_cross_reference: LCH_NW:sh85095114
database_cross_reference: MDR:10030901
database_cross_reference: MEDLINEPLUS:1503
database_cross_reference: MSH:D009894
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3289
database_cross_reference: NCI_NCI-GLOSS:CDR0000256572
database_cross_reference: NCI_NICHD:C3289
database_cross_reference: NDFRT:N0000002225
database_cross_reference: OMIM:MTHU007455
database_cross_reference: SNM:D-0109
database_cross_reference: SNMI:DE-01100
database_cross_reference: SNOMEDCT_US:61274003

Abnormal ear morphology
type: Class
subclass of: Abnormality of the ear
definition: Any structural anomaly of the ear.
PMOID: PMO:00005826
Subclass_of: Abnormality of the ear
Tree Number: T3.11.1
database_cross_reference: HPO:HP:0031703

Abnormal ear physiology
type: Class
subclass of: Abnormality of the ear
definition: Any functional anomaly of the ear.
PMOID: PMO:00006066
Subclass_of: Abnormality of the ear
Tree Number: T3.11.2
database_cross_reference: HPO:HP:0031704

Abnormal circulating glycerol level
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: Any deviation from the normal concentration of glycerol in the blood.
PMOID: PMO:00003642
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.1
database_cross_reference: HPO:HP:0031795

Vocal cord dysfunction
type: Class
subclass of: Abnormality of the voice
definition: Any functional anomaly of the vocal cord.
PMOID: PMO:00014038
Subclass_of: Abnormality of the voice
Tree Number: T3.22.11
database_cross_reference: HPO:HP:0031801

Decreased circulating parathyroid hormone level
type: Class
subclass of: Abnormality of calcium-phosphate metabolism
definition: An abnormally decreased concentration of parathyroid hormone.
PMOID: PMO:00003638
Subclass_of: Abnormality of calcium-phosphate metabolism
Synonym: Decreased circulating PTH level
Synonym: Decreased serum PTH
Synonym: Decreased serum parathyroid hormone
Synonym: Decreased serum parathyroid hormone level
Tree Number: T3.6.9.1
database_cross_reference: HPO:HP:0031817

Abnormal waist to hip ratio
type: Class
subclass of: Abnormality of body weight
definition: A deviation from normal of the waist to hip ratio, defined as the waist measurement divided by hip measurement.
PMOID: PMO:00014146
Subclass_of: Abnormality of body weight
Tree Number: T3.24.2.1
database_cross_reference: HPO:HP:0031818

Abnormal hypoxanthine-guanine phosphoribosyltransferase level
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: Altered level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.
PMOID: PMO:00003543
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Abnormal 6-hydroxypurine phosphoribosyltransferase level
Synonym: Abnormal GMP pyrophosphorylase level
Synonym: Abnormal GPRT level
Tree Number: T3.6.3.3
database_cross_reference: HPO:HP:0031821

Abnormal superoxide dismutase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: An abnormal level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
PMOID: PMO:00003552
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Abnormal superoxide:superoxide oxidoreductase activity
Tree Number: T3.6.3.6
database_cross_reference: HPO:HP:0031835

Presence of xenobiotic
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: Presence of a chemical substance found within an individual that is not naturally produced or expected to be present in human tissues or bodily fluids.
PMOID: PMO:00004269
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: The presence of a xenobiotic in body tissues or fluids can be the result of ingestion of or exposure to substances such as drugs, environmental pollutants, food additives, hydrocarbons, and pesticides.
Tree Number: T3.6.33
database_cross_reference: HPO:HP:0031838

Urine xenobiotic
type: Class
subclass of: Presence of xenobiotic
definition: The presence of a xenobiotic in urine.
PMOID: PMO:00004283
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.5
database_cross_reference: HPO:HP:0031840

Abnormal hematocrit
type: Class
subclass of: Abnormal erythrocyte morphology
definition: Any deviation from the normal ratio of the volume of red blood cells to the total volume of blood.
PMOID: PMO:00000929
Subclass_of: Abnormal erythrocyte morphology
Tree Number: T3.2.2.2
database_cross_reference: HPO:HP:0031850

Isomerism
type: Class
subclass of: Heterotaxy
definition: Isomerism in the context of the congenitally malformed heart is defined as a situation where some paired structures on opposite sides of the left-right axis of the body are, in morphologic terms, symmetrical mirror images of each other.
PMOID: PMO:00014186
Subclass_of: Heterotaxy
Tree Number: T3.24.5.2
database_cross_reference: HPO:HP:0031853

Bloodstream infectious agent
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: The presence of an infectious agent in the blood circulation.
PMOID: PMO:00004249
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.25
database_cross_reference: HPO:HP:0031863

Bacteremia
type: Class
subclass of: Bloodstream infectious agent
definition: Presence of viable bacteria in the blood.
PMOID: PMO:00004250
Subclass_of: Bloodstream infectious agent
Synonym: BACTEREMIA
Synonym: Bacteraemia
Synonym: Bacteraemia NOS
Synonym: Bacteraemia, unspecified
Synonym: Bacteremia (disorder)
Synonym: Bacteremia (finding)
Synonym: Bacteremia NOS
Synonym: Bacteremia NOS (disorder)
Synonym: Bacteremia NOS (finding)
Synonym: Bacteremia [Disease/Finding]
Tree Number: T3.6.25.1
database_cross_reference: BI:BI00698
database_cross_reference: CCPSS:1014114
database_cross_reference: CHV:0000001664
database_cross_reference: COSTAR:095
database_cross_reference: CSP:5003-0039
database_cross_reference: DXP:NOCODE
database_cross_reference: HPO:HP:0031864
database_cross_reference: ICD10CM:R78.81
database_cross_reference: ICD9CM:790.7
database_cross_reference: LCH_NW:sh85010812
database_cross_reference: MDR:10003997
database_cross_reference: MDR:10003998
database_cross_reference: MDR:10003999
database_cross_reference: MDR:10045641
database_cross_reference: MDR:10045642
database_cross_reference: MDR:10060562
database_cross_reference: MEDCIN:30872
database_cross_reference: MEDLINEPLUS:3210
database_cross_reference: MSH:D016470
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:790.7
database_cross_reference: NCI:C102993
database_cross_reference: NCI_NICHD:C102993
database_cross_reference: NDFRT:N0000003416
database_cross_reference: RCD:R106.
database_cross_reference: RCD:Xa3aY
database_cross_reference: RCD:XaD2L
database_cross_reference: RCDAE:R106.
database_cross_reference: RCDAE:Xa3aY
database_cross_reference: RCDAE:XaD2L
database_cross_reference: RCDSY:R106.
database_cross_reference: SNM:F-01130
database_cross_reference: SNMI:DE-10008
database_cross_reference: SNOMEDCT_US:10001005
database_cross_reference: SNOMEDCT_US:158561001
database_cross_reference: SNOMEDCT_US:207294007
database_cross_reference: SNOMEDCT_US:311773008
database_cross_reference: SNOMEDCT_US:5758002

Abnormal Langerhans cell morphology
type: Class
subclass of: Abnormal cell morphology
definition: Any functional anomaly of Langerhans cells, which are dendritic cells in the epidermis and some other locations. Langerhans cells play roles iin immune surveillance and homeostasis.
PMOID: PMO:00000885
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.4
database_cross_reference: HPO:HP:0031871

Abnormal hepcidin level
type: Class
subclass of: Abnormality of circulating protein level
definition: Any deviation from the normal concentration of hepcidin in the blood circulation.
PMOID: PMO:00003939
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.7
database_cross_reference: HPO:HP:0031875

Rouleaux formation
type: Class
subclass of: Abnormal erythrocyte morphology
definition: Increased amount of stacking of erythrocytes into long chains. Rouleaux (singular: rouleau) is derived from a French word that can refer to a stack of coins put into a cylindircal paper roll. Rouleaux formation is observed with increased serum proteins, particularly fibrinogen and globulins, and represents the cause of increased erythrocte sedimentation rate because rouleaux sediment more readily than isolated red blood cells.
PMOID: PMO:00001030
Subclass_of: Abnormal erythrocyte morphology
Synonym: Increased rouleaux formation
Tree Number: T3.2.2.18
database_cross_reference: HPO:HP:0031898

Abnormal serum mast cell beta-tryptase concentration
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: Any deviation from the normal circulating concentration of mast cell beta-tryptase concentration.
PMOID: PMO:00003549
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.5
database_cross_reference: HPO:HP:0031900

Abnormal serum selenium concentration
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: Any deviation from the normal circulating concentration of selenium.
PMOID: PMO:00003595
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.6
database_cross_reference: HPO:HP:0031903

Abnormal cranial nerve physiology
type: Class
subclass of: Abnormality of nervous system physiology
definition: A functional abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem.
PMOID: PMO:00010553
Subclass_of: Abnormality of nervous system physiology
Tree Number: T3.18.3.2
database_cross_reference: HPO:HP:0031910

Rosette
type: Class
subclass of: Abnormal cell morphology
definition: A halo or spoke-wheel arrangement of cells surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core; the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub.
PMOID: PMO:00000889
Subclass_of: Abnormal cell morphology
Tree Number: T3.1.1.6
database_cross_reference: HPO:HP:0031925

Abnormal serum anion gap
type: Class
subclass of: Abnormality of acid-base homeostasis
definition: Any deviation from the normal value of the serum anion gap, which is calculated from the electrolytes measured in the chemical laboratory, is defined as the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration.
PMOID: PMO:00003599
Subclass_of: Abnormality of acid-base homeostasis
Tree Number: T3.6.8.1
database_cross_reference: HPO:HP:0031961

Increased RBC distribution width
type: Class
subclass of: Abnormal erythrocyte morphology
definition: Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage.
PMOID: PMO:00001013
Subclass_of: Abnormal erythrocyte morphology
Synonym: Increased red blood cell distribution width
Tree Number: T3.2.2.14
database_cross_reference: HPO:HP:0031965

Abnormal blood urea nitrogen
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: Any deviation from the normal concentration of urea nitrogen in the blood.
PMOID: PMO:00004139
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.1
database_cross_reference: HPO:HP:0031970

Presyncope
type: Class
subclass of: Abnormality of cardiovascular system physiology
definition: Presyncope is a state of lightheadedness, muscular weakness, blurred vision, and feeling faint. Presyncope is most often cardiovascular in cause.
PMOID: PMO:00004952
Subclass_of: Abnormality of cardiovascular system physiology
Synonym: NEAR SYNCOPE
Synonym: Near syncope
Synonym: Near syncope (disorder)
Synonym: PRESYNCOPE
Synonym: Pre-syncope
Synonym: Presyncopes
Synonym: near syncope
Synonym: pre syncope
Synonym: pre-syncope
Synonym: presyncope
Tree Number: T3.9.3.13
database_cross_reference: BI:BI00557
database_cross_reference: CCPSS:1004860
database_cross_reference: CHV:0000044688
database_cross_reference: COSTAR:U000441
database_cross_reference: CST:DIZZINESS
database_cross_reference: HPO:HP:0031972
database_cross_reference: MDR:10036507
database_cross_reference: MDR:10036653
database_cross_reference: MDR:10066203
database_cross_reference: MSH:D013575
database_cross_reference: NCI:C80100
database_cross_reference: NCI_CTCAE:E12778
database_cross_reference: NCI_NICHD:C80100
database_cross_reference: SNOMEDCT_US:427461000

Abnormal sputum
type: Class
subclass of: Abnormal respiratory system morphology
definition: Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin.
PMOID: PMO:00011490
Subclass_of: Abnormal respiratory system morphology
Synonym: Abnormal sputum morphology
Tree Number: T3.19.1.4
database_cross_reference: HPO:HP:0032016

Muscle eosinophilia
type: Class
subclass of: Abnormal muscle morphology
definition: Eosinophil infiltration of skeletal muscle.
PMOID: PMO:00009568
Subclass_of: Abnormal muscle morphology
Synonym: Eosinophilic infiltration of skeletal muscle
Tree Number: T3.17.1.9
database_cross_reference: HPO:HP:0032019

Reduced serum alpha-1-antitrypsin
type: Class
subclass of: Abnormality of circulating protein level
definition: A reduced concentration of circulating alpha-1 antitrypsin, which is a 52-kDa glycoprotein mainly synthesised and secreted by hepatocytes into the bloodstream. Alpha-1 antitrypsin is a serine-proteinase inhibitor that it is crucial in maintaining protease-antiprotease homeostasis in the lungs.
PMOID: PMO:00003971
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.24
database_cross_reference: HPO:HP:0032025

Abnormal serum bicarbonate concentration
type: Class
subclass of: Abnormality of acid-base homeostasis
definition: Any deviation from the normal concentration of bicarbonate, HCO3[-], in the circulation.
PMOID: PMO:00003602
Subclass_of: Abnormality of acid-base homeostasis
Tree Number: T3.6.8.2
database_cross_reference: HPO:HP:0032065

Abnormality of the hemidiaphragms
type: Class
subclass of: Abnormality of the diaphragm
PMOID: PMO:00009713
Subclass_of: Abnormality of the diaphragm
Tree Number: T3.17.8.1
database_cross_reference: HPO:HP:0040045

Decreased adipose tissue
type: Class
subclass of: Abnormal adipose tissue morphology
PMOID: PMO:00001275
Subclass_of: Abnormal adipose tissue morphology
Synonym: Decreased fat tissue
Synonym: Fat tissue decreased
Tree Number: T3.3.1.4
database_cross_reference: HPO:HP:0040063
database_cross_reference: MDR:10073170

Abnormality of limbs
type: Class
subclass of: Phenotypic Abnormality
PMOID: PMO:00002493
Subclass_of: Phenotypic Abnormality
Synonym: Abnormal limbs
Synonym: Deformity of limb
Synonym: Deformity of limb (finding)
Synonym: EXTREMITY DEFORMITY
Synonym: Extremity deformities
Synonym: Limb deformities
Synonym: Limb deformities NOS
Synonym: Limb deformity
Synonym: Limb deformity NOS
Synonym: abnormalities limb
Tree Number: T3.5
database_cross_reference: CHV:0000024191
database_cross_reference: DXP:U001220
database_cross_reference: HPO:HP:0040064
database_cross_reference: MDR:10012139
database_cross_reference: MDR:10024495
database_cross_reference: MDR:10053652
database_cross_reference: OMIM:MTHU041883
database_cross_reference: SNOMEDCT_US:268132009
database_cross_reference: SNOMEDCT_US:445144002
database_cross_reference: SNOMEDCT_VET:34281000009104

Abnormality of limb bone
type: Class
subclass of: Abnormality of limbs
PMOID: PMO:00002494
Subclass_of: Abnormality of limbs
Tree Number: T3.5.1
database_cross_reference: HPO:HP:0040068

Abnormality of lower limb bone
type: Class
subclass of: Abnormality of limb bone
PMOID: PMO:00002495
Subclass_of: Abnormality of limb bone
Tree Number: T3.5.1.1
database_cross_reference: HPO:HP:0040069

Abnormality of upper limb bone
type: Class
subclass of: Abnormality of the upper limb
PMOID: PMO:00003120
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.5
database_cross_reference: HPO:HP:0040070

Abnormal circulating renin
type: Class
subclass of: Abnormality of renin-angiotensin system
PMOID: PMO:00006202
Subclass_of: Abnormality of renin-angiotensin system
Synonym: Abnormal plasma renin
Tree Number: T3.12.4.2
database_cross_reference: HPO:HP:0040084

Abnormal circulating aldosterone
type: Class
subclass of: Abnormality of renin-angiotensin system
PMOID: PMO:00006201
Subclass_of: Abnormality of renin-angiotensin system
Synonym: Abnormal plasma aldosterone
Tree Number: T3.12.4.1
database_cross_reference: HPO:HP:0040085

Abnormal sweat homeostasis
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An abnormality of the composition of sweat or the levels of its components.
PMOID: PMO:00003596
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.7
database_cross_reference: HPO:HP:0040127

Abnormal sweat electrolytes
type: Class
subclass of: Abnormal sweat homeostasis
PMOID: PMO:00003597
Subclass_of: Abnormal sweat homeostasis
Tree Number: T3.6.7.1
database_cross_reference: HPO:HP:0040128

5-oxoprolinase deficiency
type: Class
subclass of: Abnormality of metabolism/homeostasis
PMOID: PMO:00003475
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: 5-@OXOPROLINASE DEFICIENCY
Synonym: 5-OXOPROLINASE DEFICIENCY
Synonym: 5-Oxoprolinase deficiency
Synonym: 5-Oxoprolinase deficiency (disorder)
Synonym: 5-alpha-oxoprolinase deficiency
Synonym: OPLAHD
Synonym: OXOPROLINURIA DUE TO 5-OXOPROLINASE DEFICIENCY
Synonym: Oxoprolinuria Due To Oxoprolinase Deficiency
Synonym: Oxoprolinuria due to 5-oxoprolinase deficiency
Synonym: Pyroglutamate hydrolase deficiency
Tree Number: T3.6.1
database_cross_reference: HPO:HP:0040142
database_cross_reference: MSH:C535322
database_cross_reference: OMIM:260005
database_cross_reference: OMIM:614243
database_cross_reference: OMIM:MTHU037864
database_cross_reference: RCD:Xa6b1
database_cross_reference: SNMI:D6-A3570
database_cross_reference: SNOMEDCT_US:26132002

Abnormality of the periosteum
type: Class
subclass of: Abnormality of the skeletal system
PMOID: PMO:00013993
Subclass_of: Abnormality of the skeletal system
Tree Number: T3.20.3
database_cross_reference: HPO:HP:0040166

Abnormality of occipitofrontalis muscle
type: Class
subclass of: Abnormality of the musculature
PMOID: PMO:00009671
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.4
database_cross_reference: HPO:HP:0040172

Platelet-activating factor acetylhydrolase deficiency
type: Class
subclass of: Abnormal enzyme/coenzyme activity
PMOID: PMO:00003584
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: PAFAD
Synonym: PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE DEFICIENCY
Synonym: Platelet-Activating Factor Acetylhydrolase Deficiency
Tree Number: T3.6.3.13
database_cross_reference: HPO:HP:0040175
database_cross_reference: MSH:C566640
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:601690
database_cross_reference: OMIM:614278

Abnormal level of phospholipids
type: Class
subclass of: Abnormality of lipid metabolism
PMOID: PMO:00004067
Subclass_of: Abnormality of lipid metabolism
Tree Number: T3.6.17.1
database_cross_reference: HPO:HP:0040176

APUdoma
type: Class
subclass of: Neoplasm of the endocrine system
definition: An endocrine tumor arising from an APUD cell.
PMOID: PMO:00006373
Subclass_of: Neoplasm of the endocrine system
Synonym: APUDoma
Synonym: APUDoma NOS
Synonym: Apudoma
Synonym: Apudoma (diagnosis)
Synonym: Apudoma (disorder)
Synonym: Apudoma (morphologic abnormality)
Synonym: Apudoma [Disease/Finding]
Synonym: Apudomas
Synonym: Neoplasm of Diffuse Neuroendocrine System
Synonym: Neoplasm of the Diffuse Neuroendocrine System
Tree Number: T3.12.14.1
database_cross_reference: CHV:0000001404
database_cross_reference: HPO:HP:0040192
database_cross_reference: ICD10AM:M8248/1
database_cross_reference: MDR:10003069
database_cross_reference: MDR:10003070
database_cross_reference: MEDCIN:355431
database_cross_reference: MSH:D001079
database_cross_reference: NCI:C2879
database_cross_reference: NDFRT:N0000000459
database_cross_reference: RCD:BB5y3
database_cross_reference: RCD:X77nZ
database_cross_reference: RCDSY:BB5y3
database_cross_reference: SNMI:M-82481
database_cross_reference: SNOMEDCT_US:253008000
database_cross_reference: SNOMEDCT_US:74926005

Abnormal level of neopterin
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: The presence of an abnormal concentration of neopterin.
PMOID: PMO:00004150
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.5
database_cross_reference: HPO:HP:0040206

Abnormal level of biopterin
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: The presence of an abnormal concentration of biopterin.
PMOID: PMO:00004146
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.4
database_cross_reference: HPO:HP:0040210

Abnormal insulin level
type: Class
subclass of: Abnormality of circulating hormone level
definition: An abnormal concentration of insulin in the body.
PMOID: PMO:00006169
Subclass_of: Abnormality of circulating hormone level
Tree Number: T3.12.3.10
database_cross_reference: HPO:HP:0040214

Maternal thrombophilia
type: Class
subclass of: Prenatal maternal abnormality
definition: An increased tendency towards thrombosis in the mother during a pregnancy.
PMOID: PMO:00004401
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.9
database_cross_reference: HPO:HP:0040222

Abnormality of fibrinolysis
type: Class
subclass of: Abnormality of coagulation
definition: Clincial phenotype characterized by delayed bleeding accelerated break down of blood clot (fibrinolysis)
PMOID: PMO:00001148
Subclass_of: Abnormality of coagulation
Synonym: Abnormality of the fibrinolytic system
Tree Number: T3.2.8.1
database_cross_reference: HPO:HP:0040224

Abnormal onset of bleeding
type: Class
subclass of: Abnormal bleeding
PMOID: PMO:00000907
Subclass_of: Abnormal bleeding
Tree Number: T3.2.1.1
database_cross_reference: HPO:HP:0040231

Muscle haemorrhage
type: Class
subclass of: Abnormality of the musculature
definition: Haemorrhage occurring within a muscle
PMOID: PMO:00009758
Subclass_of: Abnormality of the musculature
Synonym: HEMORRHAGE MUSCLE
Synonym: Haemorrhage muscle
Synonym: Haemorrhage of muscle
Synonym: Haemorrhage of muscle, NOS
Synonym: Hemorrhage muscle
Synonym: Hemorrhage of muscle
Synonym: Hemorrhage of muscle (disorder)
Synonym: Hemorrhage of muscle, NOS
Synonym: MUSCLE HAEMORRHAGE
Synonym: MUSCLE HEMORRHAGE
Tree Number: T3.17.16
database_cross_reference: CST:HEM MUSCLE
database_cross_reference: HPO:HP:0040242
database_cross_reference: MDR:10019560
database_cross_reference: MDR:10028309
database_cross_reference: MDR:10028310
database_cross_reference: MDR:10055824
database_cross_reference: MDR:10071842
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:D1-50850
database_cross_reference: SNOMEDCT_US:95422003

Jaw pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the jaw.
PMOID: PMO:00014098
Subclass_of: Pain
Synonym: Gnathodynia
Synonym: JAW BONE PAIN
Synonym: JAW PAIN
Synonym: Jaw bone pain
Synonym: Jaw pain (finding)
Synonym: Lower jaw pain
Synonym: MANDIBULAR PAIN
Synonym: Mandibular pain
Synonym: PAIN JAW
Synonym: Pain in jaw
Tree Number: T3.23.10.19
database_cross_reference: CCPSS:0025667
database_cross_reference: CHV:0000018291
database_cross_reference: CHV:0000023658
database_cross_reference: CST:PAIN
database_cross_reference: CST:PAIN BONE
database_cross_reference: DXP:U002205
database_cross_reference: DXP:U002501
database_cross_reference: HPO:HP:0040264
database_cross_reference: HPO:HP:0200025
database_cross_reference: ICD10CM:R68.84
database_cross_reference: ICD9CM:784.92
database_cross_reference: ICPC2P:L07001
database_cross_reference: MDR:10023143
database_cross_reference: MDR:10023157
database_cross_reference: MDR:10033433
database_cross_reference: MDR:10033455
database_cross_reference: MDR:10072238
database_cross_reference: MEDCIN:181
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:784.92
database_cross_reference: OMIM:MTHU036747
database_cross_reference: RCD:XM1B6
database_cross_reference: RCD:Xa8IQ
database_cross_reference: RCDSY:Xa8IQ
database_cross_reference: SNMI:D5-14010
database_cross_reference: SNOMEDCT_US:206948006
database_cross_reference: SNOMEDCT_US:274667000
database_cross_reference: SNOMEDCT_US:302241006
database_cross_reference: SNOMEDCT_US:95523006

Neoplasm of the pituitary gland
type: Class
subclass of: Neoplasm of the endocrine system
PMOID: PMO:00006377
Subclass_of: Neoplasm of the endocrine system
Synonym: Neoplasm of Pituitary
Synonym: Neoplasm of Pituitary Gland
Synonym: Neoplasm of pituitary gland
Synonym: Neoplasm of pituitary gland (disorder)
Synonym: Neoplasm of the Pituitary
Synonym: Neoplasm of the Pituitary Gland
Synonym: Neoplasm, Pituitary
Synonym: Neoplasms, Pituitary
Synonym: PITUITARY NEOPL
Synonym: PITUITARY NEOPLASM
Tree Number: T3.12.14.3
database_cross_reference: CCPSS:0023924
database_cross_reference: CHV:0000009767
database_cross_reference: COSTAR:U000534
database_cross_reference: CSP:2006-7421
database_cross_reference: DO:DOID:1785
database_cross_reference: DXP:U003156
database_cross_reference: HPO:HP:0040277
database_cross_reference: ICPC2P:T73003
database_cross_reference: LCH_NW:sh85102525
database_cross_reference: MDR:10035086
database_cross_reference: MDR:10035097
database_cross_reference: MDR:10035098
database_cross_reference: MDR:10035102
database_cross_reference: MDR:10035104
database_cross_reference: MDR:10035107
database_cross_reference: MEDCIN:30502
database_cross_reference: MEDLINEPLUS:5328
database_cross_reference: MSH:D010911
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3330
database_cross_reference: NCI_NCI-GLOSS:CDR0000446420
database_cross_reference: NDFRT:N0000002408
database_cross_reference: PDQ:CDR0000038812
database_cross_reference: RCD:X78a9
database_cross_reference: RCDAE:X78a9
database_cross_reference: SNOMEDCT_US:127024001

Abnormality of axial muscles
type: Class
subclass of: Abnormality of the musculature
PMOID: PMO:00009588
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.2
database_cross_reference: HPO:HP:0040286

Axial muscle atrophy
type: Class
subclass of: Abnormality of axial muscles
PMOID: PMO:00009589
Subclass_of: Abnormality of axial muscles
Tree Number: T3.17.2.1
database_cross_reference: HPO:HP:0040287

Abnormality of skeletal muscles
type: Class
subclass of: Abnormality of the musculature
PMOID: PMO:00009672
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.5
database_cross_reference: HPO:HP:0040290

Skeletal muscle steatosis
type: Class
subclass of: Abnormality of skeletal muscles
PMOID: PMO:00009709
Subclass_of: Abnormality of skeletal muscles
Synonym: Steatosis of skeletal muscle
Synonym: Steatosis of skeletal muscles
Tree Number: T3.17.5.3
database_cross_reference: HPO:HP:0040291

Hypolipidemia
type: Class
subclass of: Abnormality of lipid metabolism
PMOID: PMO:00004136
Subclass_of: Abnormality of lipid metabolism
Synonym: HYPOLIPEMIA
Synonym: Hypolipaemia
Synonym: Hypolipemia
Synonym: Hypolipidaemia
Synonym: Hypolipidemia (disorder)
Synonym: hypolipemia
Synonym: hypolipidemia
Tree Number: T3.6.17.7
database_cross_reference: CHV:0000030801
database_cross_reference: CSP:1744-2978
database_cross_reference: CST:HYPOLIPEM
database_cross_reference: HPO:HP:0045014
database_cross_reference: MDR:10021023
database_cross_reference: MDR:10021024
database_cross_reference: MDR:10021025
database_cross_reference: MDR:10060386
database_cross_reference: OMIM:MTHU056858
database_cross_reference: RCD:X40XP
database_cross_reference: RCDAE:X40XP
database_cross_reference: SNOMEDCT_US:238090007

Abnormality of the mediastinum
type: Class
subclass of: Abnormality of the thoracic cavity
PMOID: PMO:00014016
Subclass_of: Abnormality of the thoracic cavity
Tree Number: T3.21.1
database_cross_reference: HPO:HP:0045026

Abnormality of the thoracic cavity
type: Class
subclass of: Phenotypic Abnormality
PMOID: PMO:00014015
Subclass_of: Phenotypic Abnormality
Tree Number: T3.21
database_cross_reference: HPO:HP:0045027

Abnormal lactate dehydrogenase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate.
PMOID: PMO:00003546
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.4
database_cross_reference: HPO:HP:0045040

Abnormal levels of alpha-fetoprotein
type: Class
subclass of: Abnormality of circulating protein level
PMOID: PMO:00003944
Subclass_of: Abnormality of circulating protein level
Tree Number: T3.6.12.9
database_cross_reference: HPO:HP:0045056

Abnormality of body mass index
type: Class
subclass of: Abnormality of body weight
definition: Anomaly in the weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of obesity and underweight compared to averages.
PMOID: PMO:00014149
Subclass_of: Abnormality of body weight
Synonym: Abnormal BMI
Synonym: Abnormal body mass index
Tree Number: T3.24.2.2
database_cross_reference: HPO:HP:0045081

Early onset of sexual maturation
type: Class
subclass of: Puberty and gonadal disorders
definition: An early onset of puberty, in this case early does not refer to precocious.
PMOID: PMO:00006406
Subclass_of: Puberty and gonadal disorders
Tree Number: T3.12.15.7
database_cross_reference: HPO:HP:0100000

Malignant mesothelioma
type: Class
subclass of: Neoplasm by anatomical site
definition: Malignant mesothelioma is a form of cancer that originates from the cells of the mesothelium, a thin tissue layer surrounding the body's internal organs. Malignant mesothelioma is almost exclusively caused by asbestos exposure, pleural mesothelioma beeing the most common form, affecting the lining of the lungs called the pleura. Other forms such as perioneal-, percardial- or testicular- mesothelioma are much rarer.
PMOID: PMO:00014193
Subclass_of: Neoplasm by anatomical site
Synonym: Cancer, mesothelioma
Synonym: MESOM
Synonym: MESOTHELIOMA, MALIGNANT
Synonym: Malignant Mesothelial Neoplasm
Synonym: Malignant Mesothelial Tumor
Synonym: Malignant Mesothelioma
Synonym: Malignant Neoplasm of Mesothelium
Synonym: Malignant Neoplasm of the Mesothelium
Synonym: Malignant Tumor of Mesothelium
Synonym: Malignant Tumor of the Mesothelium
Tree Number: T3.25.1.1
database_cross_reference: CHV:0000031033
database_cross_reference: HPO:HP:0100001
database_cross_reference: ICD10AM:M9050/3
database_cross_reference: MDR:10027407
database_cross_reference: MDR:10027410
database_cross_reference: MEDCIN:335197
database_cross_reference: MEDLINEPLUS:4014
database_cross_reference: MSH:C562839
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4456
database_cross_reference: NCI_CDISC:C4456
database_cross_reference: NCI_NCI-GLOSS:CDR0000044992
database_cross_reference: OMIM:156240
database_cross_reference: OMIM:MTHU053483
database_cross_reference: PDQ:CDR0000038142
database_cross_reference: RCD:BBP1.
database_cross_reference: SNM:M-9050/3
database_cross_reference: SNMI:M-90503
database_cross_reference: SNOMEDCT_US:109378008
database_cross_reference: SNOMEDCT_US:62064005
database_cross_reference: SNOMEDCT_VET:109378008

Neoplasm of the eye
type: Class
subclass of: Neoplasm by anatomical site
definition: A tumor (abnormal growth of tissue) of the eye.
PMOID: PMO:00014213
Subclass_of: Neoplasm by anatomical site
Synonym: EYE NEOPL
Synonym: Eye Neoplasm
Synonym: Eye Neoplasms
Synonym: Eye Neoplasms [Disease/Finding]
Synonym: Eye Tumor
Synonym: Eye tumor
Synonym: Eye--Tumors
Synonym: NEOPL EYE
Synonym: Neoplasia of the eye
Synonym: Neoplasm eye NOS
Tree Number: T3.25.1.5
database_cross_reference: CHV:0000004829
database_cross_reference: CSP:2018-3273
database_cross_reference: DO:DOID:2174
database_cross_reference: HPO:HP:0100012
database_cross_reference: ICPC2P:F74004
database_cross_reference: LCH_NW:sh85046682
database_cross_reference: MDR:10030054
database_cross_reference: MDR:10048730
database_cross_reference: MDR:10052448
database_cross_reference: MEDCIN:34022
database_cross_reference: MEDCIN:34023
database_cross_reference: MSH:D005134
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3030
database_cross_reference: NDFRT:N0000001186
database_cross_reference: RCD:X78ax
database_cross_reference: RCDAE:X78ax
database_cross_reference: SNOMEDCT_US:126995000
database_cross_reference: SNOMEDCT_US:371486001

Neoplasm of the breast
type: Class
subclass of: Neoplasm by anatomical site
definition: A tumor (abnormal growth of tissue) of the breast.
PMOID: PMO:00014207
Subclass_of: Neoplasm by anatomical site
Synonym: BREAST NEOPL
Synonym: BREAST NEOPLASM
Synonym: Breast Neoplasm
Synonym: Breast Neoplasms
Synonym: Breast Neoplasms [Disease/Finding]
Synonym: Breast Tumor
Synonym: Breast Tumors
Synonym: Breast neoplasm
Synonym: Breast neoplasm NOS
Synonym: Breast tumor
Tree Number: T3.25.1.4
database_cross_reference: AOD:0000023048
database_cross_reference: AOD:0000023049
database_cross_reference: CHV:0000002156
database_cross_reference: COSTAR:U000090
database_cross_reference: CSP:2001-3195
database_cross_reference: CSP:2016-0671
database_cross_reference: CST:NEOPL BREAST
database_cross_reference: HPO:HP:0100013
database_cross_reference: LCH_NW:sh85016690
database_cross_reference: LNC:LP36755-4
database_cross_reference: LNC:MTHU019437
database_cross_reference: MDR:10006279
database_cross_reference: MDR:10006285
database_cross_reference: MDR:10028985
database_cross_reference: MEDCIN:31643
database_cross_reference: MEDCIN:39311
database_cross_reference: MSH:D001943
database_cross_reference: MTH:120
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2910
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_FDA:2438
database_cross_reference: NDFRT:N0000000612
database_cross_reference: PSY:06940
database_cross_reference: PSY:29330
database_cross_reference: RCD:X40G6
database_cross_reference: RCDAE:X40G6
database_cross_reference: SNOMEDCT_US:126926005

Abnormality of mesentery morphology
type: Class
subclass of: Abnormality of the abdominal organs
definition: Folds of membranous tissue (peritoneum, mesothelium) attached to the wall of the abdomen and enclosing viscera. Examples include the mesentery for the small intestine; the transverse mesocolon, which attaches the transverse portion of the colon to the back wall of the abdomen; and the mesosigmoid, which enfolds the sigmoid portion of the colon. Cells of the same embryologic origin also surround the other organs of the body such as the lungs (pleura) or the heart (pericardium).
PMOID: PMO:00005372
Subclass_of: Abnormality of the abdominal organs
Tree Number: T3.10.4.1
database_cross_reference: HPO:HP:0100016

Abnormality of movement
type: Class
subclass of: Abnormality of nervous system physiology
definition: An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements.
PMOID: PMO:00010872
Subclass_of: Abnormality of nervous system physiology
Synonym: DYSKINESIA SYNDROME
Synonym: Dyskinesia Syndrome
Synonym: Dyskinesia Syndromes
Synonym: Dyskinesia syndrome
Synonym: MOVEMENT DIS
Synonym: MOVEMENT DIS SYNDROMES
Synonym: MOVEMENT DISORDER
Synonym: MOVEMENT DISORDER (NOS)
Synonym: MOVEMENT DISORDERS
Synonym: Movement Disorder
Tree Number: T3.18.3.10
database_cross_reference: CCPSS:0042860
database_cross_reference: CHV:0000008293
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2057-3596
database_cross_reference: CSP:2057-3603
database_cross_reference: CST:DYSKINESIA
database_cross_reference: CST:MOVEMENT DIS
database_cross_reference: CST:NERMOVE
database_cross_reference: DO:DOID:480
database_cross_reference: HPO:HP:0100022
database_cross_reference: LCH:U003043
database_cross_reference: LCH_NW:sh85088017
database_cross_reference: MDR:10013927
database_cross_reference: MDR:10028035
database_cross_reference: MDR:10028036
database_cross_reference: MDR:10028040
database_cross_reference: MDR:10048523
database_cross_reference: MEDCIN:276423
database_cross_reference: MEDLINEPLUS:520
database_cross_reference: MSH:D009069
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C116757
database_cross_reference: NCI_NICHD:C116757
database_cross_reference: NDFRT:N0000002039
database_cross_reference: OMIM:MTHU006688
database_cross_reference: OMIM:MTHU044333
database_cross_reference: PSY:32375
database_cross_reference: SNMI:DA-21100
database_cross_reference: SNOMEDCT_US:60342002

Sarcoma
type: Class
subclass of: Neoplasm by histology
definition: A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.
PMOID: PMO:00014345
Subclass_of: Neoplasm by histology
Synonym: Connective Tissue Sarcoma
Synonym: Malig tumor of soft tissue
Synonym: Malig tumour of soft tissue
Synonym: Malignant Neoplasm of Soft Tissue
Synonym: Malignant Neoplasm of the Soft Tissue
Synonym: Malignant Soft Tissue Neoplasm
Synonym: Malignant Soft Tissue Tumor
Synonym: Malignant Tumor of Soft Tissue
Synonym: Malignant Tumor of the Soft Tissue
Synonym: Malignant mesenchymal tumor
Tree Number: T3.25.2.7
database_cross_reference: AOD:0000004530
database_cross_reference: CCPSS:0020102
database_cross_reference: CCPSS:0046778
database_cross_reference: CHV:0000042636
database_cross_reference: CHV:0000056478
database_cross_reference: COSTAR:U000602
database_cross_reference: CSP:2000-8986
database_cross_reference: CST:SARCOMA
database_cross_reference: DO:DOID:0050652
database_cross_reference: HPO:HP:0030448
database_cross_reference: HPO:HP:0100242
database_cross_reference: ICD10AM:M8800/3
database_cross_reference: ICPC2P:A79013
database_cross_reference: ICPC2P:L71011
database_cross_reference: LCH:U004213
database_cross_reference: LCH_NW:sh85117504
database_cross_reference: MDR:10026699
database_cross_reference: MDR:10039491
database_cross_reference: MDR:10039494
database_cross_reference: MDR:10061271
database_cross_reference: MDR:10073145
database_cross_reference: MDR:10075333
database_cross_reference: MEDCIN:231737
database_cross_reference: MEDCIN:231878
database_cross_reference: MEDCIN:271492
database_cross_reference: MEDLINEPLUS:495
database_cross_reference: MSH:D012509
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C4867
database_cross_reference: NCI:C9118
database_cross_reference: NCI:C9306
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C9118
database_cross_reference: NCI_CTEP-SDC:10039494
database_cross_reference: NCI_NCI-GLOSS:CDR0000045562
database_cross_reference: NCI_NCI-GLOSS:CDR0000046584
database_cross_reference: NCI_NICHD:C9118
database_cross_reference: NCI_NICHD:C9306
database_cross_reference: NDFRT:N0000002671
database_cross_reference: OMIM:MTHU017412
database_cross_reference: OMIM:MTHU022273
database_cross_reference: PDQ:CDR0000039253
database_cross_reference: PSY:45270
database_cross_reference: RCD:BBF1.
database_cross_reference: RCD:XE1vg
database_cross_reference: RCD:Xa97s
database_cross_reference: RCD:Xa99e
database_cross_reference: RCDAE:Xa97s
database_cross_reference: RCDAE:Xa99e
database_cross_reference: RCDSY:BBF1.
database_cross_reference: SNM:M-8800/3
database_cross_reference: SNMI:M-88003
database_cross_reference: SNOMEDCT_US:189764008
database_cross_reference: SNOMEDCT_US:2424003
database_cross_reference: SNOMEDCT_US:269469005
database_cross_reference: SNOMEDCT_US:269634000
database_cross_reference: SNOMEDCT_US:363362006
database_cross_reference: SNOMEDCT_US:424413001
database_cross_reference: SNOMEDCT_US:424952003
database_cross_reference: SNOMEDCT_US:93765001

Recurrent singultus
type: Class
subclass of: Functional respiratory abnormality
definition: A contraction of the diaphragm that repeats several times per minute. In humans, the abrupt rush of air into the lungs causes the epiglottis to close, creating a hic sound. Also known as synchronous diaphragmatic flutter (SDF), or singultus, from the Latin singult, the act of catching one's breath while sobbing. The hiccup is an involuntary action involving a reflex arc.
PMOID: PMO:00011648
Subclass_of: Functional respiratory abnormality
Synonym: Recurrent hiccough
Synonym: Recurrent hiccup
Synonym: Recurrent synchronous diaphragmatic flutter
Tree Number: T3.19.2.18
database_cross_reference: HPO:HP:0100247

Calcification of muscles
type: Class
subclass of: Abnormality of the musculature
definition: Deposition of calcium salts in muscle tissue.
PMOID: PMO:00009749
Subclass_of: Abnormality of the musculature
Synonym: Calcification of muscle
Synonym: Calcification of muscle (disorder)
Synonym: MUSCLE CALCIFICATION
Synonym: Muscular calcification
Synonym: Muscular calcification (disorder)
Synonym: Muscular calcification, NOS
Synonym: Skeletal muscle calcinosis
Synonym: calcification of muscle
Synonym: calcification of muscle (diagnosis)
Tree Number: T3.17.13
database_cross_reference: DXP:U002672
database_cross_reference: HPO:HP:0100249
database_cross_reference: MDR:10049797
database_cross_reference: MEDCIN:331452
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:D1-50200
database_cross_reference: SNOMEDCT_US:446993003
database_cross_reference: SNOMEDCT_US:57879007

Abnormal tendon morphology
type: Class
subclass of: Abnormality of skeletal morphology
definition: An abnormality of the structure or form of the tendons, also often called sinews.
PMOID: PMO:00013934
Subclass_of: Abnormality of skeletal morphology
Synonym: Abnormal shape of tendon
Synonym: Abnormality of the sinew
Tree Number: T3.20.1.6
database_cross_reference: HPO:HP:0100261

Hyponasal speech
type: Class
subclass of: Abnormality of the voice
definition: Hyponasal speech is when there is an abnormally reduced nasal airflow during speech often in a setting of nasal obstruction or congestion.
PMOID: PMO:00014034
Subclass_of: Abnormality of the voice
Tree Number: T3.22.7
database_cross_reference: HPO:HP:0100271

Amyloidosis of peripheral nerves
type: Class
subclass of: Amyloidosis
definition: The presence of amyloid deposition in the nerves of the peripheral nervous system.
PMOID: PMO:00004239
Subclass_of: Amyloidosis
Tree Number: T3.6.24.1
database_cross_reference: HPO:HP:0100292

Immunologic hypersensitivity
type: Class
subclass of: Abnormality of immune system physiology
definition: Immunological states where the immune system produces harmful responses upon reexposure to sensitising antigens.
PMOID: PMO:00008608
Subclass_of: Abnormality of immune system physiology
Synonym: Hypersensitivity (Immunologic)
Synonym: Immunologic Hypersensitivity
Tree Number: T3.15.2.11
database_cross_reference: HPO:HP:0100326
database_cross_reference: MTH:NOCODE
database_cross_reference: PSY:23810

Abnormality of lower limb joint
type: Class
subclass of: Abnormality of the lower limb
PMOID: PMO:00002690
Subclass_of: Abnormality of the lower limb
Synonym: Abnormality of the joints of the lower limbs
Tree Number: T3.5.2.2
database_cross_reference: HPO:HP:0100491

Joint contractures involving the joints of the feet
type: Class
subclass of: Flexion contracture
definition: Contractures of one ore more joints of the feet meaning chronic loss of joint motion due to structural changes in non-bony tissue.
PMOID: PMO:00001337
Subclass_of: Flexion contracture
Tree Number: T3.3.6.5
database_cross_reference: HPO:HP:0100492

Hypoammonemia
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: A decreased concentration of ammonia in the blood.
PMOID: PMO:00004162
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.9
database_cross_reference: HPO:HP:0100493

Abnormality of vitamin metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An anomaly in the metabolism of a vitamin.
PMOID: PMO:00004201
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.23
database_cross_reference: HPO:HP:0100508

Abnormality of vitamin C metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
PMOID: PMO:00004225
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.3
database_cross_reference: HPO:HP:0100509

Abnormality of vitamin D metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
PMOID: PMO:00004227
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.4
database_cross_reference: HPO:HP:0100511

Abnormality of vitamin E metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
PMOID: PMO:00004233
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.5
database_cross_reference: HPO:HP:0100514

Neoplasm of the thymus
type: Class
subclass of: Abnormality of the thymus
definition: A tumor (abnormal growth of tissue) of the thymus.
PMOID: PMO:00006285
Subclass_of: Abnormality of the thymus
Synonym: NEOPL THYMIC
Synonym: NEOPL THYMUS
Synonym: Neoplasm of Thymus
Synonym: Neoplasm of the Thymus
Synonym: Neoplasm of thymus
Synonym: Neoplasm of thymus (disorder)
Synonym: Neoplasm, Thymic
Synonym: Neoplasm, Thymus
Synonym: Neoplasms, Thymic
Synonym: Neoplasms, Thymus
Tree Number: T3.12.9.3
database_cross_reference: AOD:0000023100
database_cross_reference: CHV:0000012253
database_cross_reference: CSP:2004-8826
database_cross_reference: HPO:HP:0100521
database_cross_reference: LCH_NW:sh85135150
database_cross_reference: MDR:10056296
database_cross_reference: MEDCIN:97141
database_cross_reference: MSH:D013953
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3412
database_cross_reference: NDFRT:N0000002939
database_cross_reference: RCD:X40Om
database_cross_reference: RCDAE:X40Om
database_cross_reference: SNOMEDCT_US:127231009
database_cross_reference: SNOMEDCT_VET:127231009

Abnormality of phosphate homeostasis
type: Class
subclass of: Abnormality of ion homeostasis
definition: An abnormality of phosphate homeostasis or concentration in the body.
PMOID: PMO:00004054
Subclass_of: Abnormality of ion homeostasis
Tree Number: T3.6.15.3
database_cross_reference: HPO:HP:0100529

Abnormality of calcium-phosphate metabolism
type: Class
subclass of: Abnormality of metabolism/homeostasis
PMOID: PMO:00003637
Subclass_of: Abnormality of metabolism/homeostasis
Tree Number: T3.6.9
database_cross_reference: HPO:HP:0100530

Inflammatory abnormality of the eye
type: Class
subclass of: Abnormal eye physiology
definition: Inflammation of the eye, parts of the eye or the periorbital region.
PMOID: PMO:00007445
Subclass_of: Abnormal eye physiology
Synonym: Ocular inflammation
Tree Number: T3.13.2.12
database_cross_reference: HPO:HP:0100533

Abnormality of the fascia
type: Class
subclass of: Abnormality of connective tissue
definition: An abnormality of fascia.
PMOID: PMO:00001308
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.3
database_cross_reference: HPO:HP:0100536

Exstrophy
type: Class
subclass of: Abnormality of the abdominal wall
definition: Eversion of a hollow organ and exposure, inside out, and protruded through the abdominal wall.
PMOID: PMO:00005558
Subclass_of: Abnormality of the abdominal wall
Synonym: Exstrophy (morphologic abnormality)
Synonym: exstrophy
Tree Number: T3.10.5.4
database_cross_reference: CHV:0000004792
database_cross_reference: HPO:HP:0100548
database_cross_reference: SNM:M-21550
database_cross_reference: SNOMEDCT_US:110407002

Hemihypertrophy of lower limb
type: Class
subclass of: Hemihypertrophy
definition: Overgrowth of only one leg.
PMOID: PMO:00003472
Subclass_of: Hemihypertrophy
Synonym: Congen overgrowth lower limb
Synonym: Congenital overgrowth of lower limb
Synonym: Congenital overgrowth of lower limb (disorder)
Synonym: Overgrowth of one leg
Tree Number: T3.5.7.1
database_cross_reference: HPO:HP:0100553
database_cross_reference: RCD:PF6B.
database_cross_reference: SNOMEDCT_US:205369009

Hemihypertrophy of upper limb
type: Class
subclass of: Hemihypertrophy
definition: Overgrowth of only one arm.
PMOID: PMO:00003473
Subclass_of: Hemihypertrophy
Synonym: Overgrowth of one arm
Synonym: Overgrowth of upper limb
Synonym: Overgrowth of upper limb (disorder)
Tree Number: T3.5.7.2
database_cross_reference: HPO:HP:0100554
database_cross_reference: RCD:X786j
database_cross_reference: SNOMEDCT_US:253920006

Asymmetric growth
type: Class
subclass of: Growth abnormality
definition: A growth pattern that displays an abnormal difference between the left and the right side.
PMOID: PMO:00014171
Subclass_of: Growth abnormality
Synonym: Uneven or disproportionate growth of one body part compared to another
Tree Number: T3.24.3
database_cross_reference: HPO:HP:0100555

Lower limb asymmetry
type: Class
subclass of: Abnormality of the lower limb
definition: A difference in length or diameter between the left and right leg.
PMOID: PMO:00002828
Subclass_of: Abnormality of the lower limb
Tree Number: T3.5.2.10
database_cross_reference: HPO:HP:0100559

Upper limb asymmetry
type: Class
subclass of: Abnormality of the upper limb
definition: Difference in length or size between the right and left arm.
PMOID: PMO:00003446
Subclass_of: Abnormality of the upper limb
Tree Number: T3.5.4.12
database_cross_reference: HPO:HP:0100560

Neoplasm of the endocrine system
type: Class
subclass of: Abnormality of the endocrine system
definition: A tumor (abnormal growth of tissue) of the endocrine system.
PMOID: PMO:00006372
Subclass_of: Abnormality of the endocrine system
Synonym: ENDOCRINE GLAND NEOPL
Synonym: ENDOCRINE NEOPLASIA
Synonym: Endocrine Gland Neoplasm
Synonym: Endocrine Gland Neoplasms
Synonym: Endocrine Gland Neoplasms [Disease/Finding]
Synonym: Endocrine Neoplasm
Synonym: Endocrine Neoplasms
Synonym: Endocrine System Neoplasm
Synonym: Endocrine System Tumor
Synonym: Endocrine Tumor
Tree Number: T3.12.14
database_cross_reference: AOD:0000023101
database_cross_reference: AOD:0000023102
database_cross_reference: CCPSS:0035534
database_cross_reference: CHV:0000004449
database_cross_reference: CHV:0000047500
database_cross_reference: CSP:2009-5861
database_cross_reference: DO:DOID:170
database_cross_reference: HPO:HP:0100568
database_cross_reference: ICPC2P:T73005
database_cross_reference: LCH_NW:sh87001844
database_cross_reference: MDR:10014709
database_cross_reference: MDR:10061121
database_cross_reference: MEDCIN:90717
database_cross_reference: MSH:D004701
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3010
database_cross_reference: NDFRT:N0000001100
database_cross_reference: PSY:17340
database_cross_reference: RCD:X78cM
database_cross_reference: RCDAE:X78cM
database_cross_reference: SNOMEDCT_US:127015005
database_cross_reference: SNOMEDCT_US:387922007
database_cross_reference: SNOMEDCT_US:387927001

Urogenital fistula
type: Class
subclass of: Abnormality of the genitourinary system
definition: The presence of a fistula affecting the genitourinary system.
PMOID: PMO:00008242
Subclass_of: Abnormality of the genitourinary system
Synonym: Genitourinary Fistula
Synonym: Urogenital Fistula
Synonym: Urogenital fistula NOS
Synonym: genitourinary fistula
Synonym: genitourinary fistula (diagnosis)
Tree Number: T3.14.4
database_cross_reference: HPO:HP:0100589
database_cross_reference: MDR:10046696
database_cross_reference: MDR:10046698
database_cross_reference: MEDCIN:363310
database_cross_reference: NCI:C9489

Toxemia of pregnancy
type: Class
subclass of: Prenatal maternal abnormality
definition: Pregnancy-induced toxic reactions of the mother that can be as harmless as slight Maternal hypertension or as life threatening as Eclampsia.
PMOID: PMO:00004406
Subclass_of: Prenatal maternal abnormality
Synonym: Hypertensive disorder of pregnancy
Tree Number: T3.7.11.13
database_cross_reference: HPO:HP:0100603

Neoplasm of the lip
type: Class
subclass of: Neoplasm by anatomical site
definition: A tumor (abnormal growth of tissue) of the lip.
PMOID: PMO:00014218
Subclass_of: Neoplasm by anatomical site
Synonym: LIP NEOPL
Synonym: Lip Neoplasm
Synonym: Lip Neoplasms
Synonym: Lip Neoplasms [Disease/Finding]
Synonym: Lip Tumor
Synonym: Lip neoplasm
Synonym: Lip neoplasm NOS
Synonym: Lip tumor
Synonym: Lips--Tumors
Synonym: NEOPL LIP
Tree Number: T3.25.1.6
database_cross_reference: CHV:0000007448
database_cross_reference: HPO:HP:0100604
database_cross_reference: LCH_NW:sh85077324
database_cross_reference: MDR:10049549
database_cross_reference: MDR:10062038
database_cross_reference: MEDCIN:35228
database_cross_reference: MSH:D008048
database_cross_reference: NCI:C3191
database_cross_reference: NDFRT:N0000001847
database_cross_reference: RCD:X20TR
database_cross_reference: RCDAE:X20TR
database_cross_reference: SNOMEDCT_US:126770008

Neoplasm of the respiratory system
type: Class
subclass of: Neoplasm by anatomical site
definition: A tumor (abnormal growth of tissue) of the respiratory system.
PMOID: PMO:00014238
Subclass_of: Neoplasm by anatomical site
Synonym: Neoplasm of Respiratory Tract
Synonym: Neoplasm of respiratory system
Synonym: Neoplasm of respiratory system (disorder)
Synonym: Neoplasm of respiratory tract
Synonym: Neoplasm of respiratory tract (disorder)
Synonym: Neoplasm of the Respiratory Tract
Synonym: Neoplasm, Respiratory Tract
Synonym: Neoplasm;respiratory
Synonym: Neoplasms, Respiratory Tract
Synonym: RESPIRATORY TRACT NEOPL
Tree Number: T3.25.1.9
database_cross_reference: AOD:0000023031
database_cross_reference: CHV:0000010771
database_cross_reference: CSP:2017-5336
database_cross_reference: HPO:HP:0100606
database_cross_reference: ICPC2P:R86005
database_cross_reference: ICPC2P:R92003
database_cross_reference: MDR:10029107
database_cross_reference: MDR:10038735
database_cross_reference: MDR:10061486
database_cross_reference: MSH:D012142
database_cross_reference: NCI:C3355
database_cross_reference: NDFRT:N0000002604
database_cross_reference: SNOMEDCT_US:126667002
database_cross_reference: SNOMEDCT_US:448708002

Maternal hyperphenylalaninemia
type: Class
subclass of: Prenatal maternal abnormality
definition: A medical history of exposure during the fetal period to hyperphenylalaninemia because the mother had phenylketonuria with inadequate control during pregnancy.
PMOID: PMO:00004399
Subclass_of: Prenatal maternal abnormality
Synonym: High blood phenylalanine level in mother
Tree Number: T3.7.11.7
database_cross_reference: HPO:HP:0100610

Maternal seizures
type: Class
subclass of: Prenatal maternal abnormality
PMOID: PMO:00004400
Subclass_of: Prenatal maternal abnormality
Tree Number: T3.7.11.8
database_cross_reference: HPO:HP:0100622

Neuroendocrine neoplasm
type: Class
subclass of: Neoplasm of the endocrine system
PMOID: PMO:00006378
Subclass_of: Neoplasm of the endocrine system
Synonym: NEUROENDOCRINE TUMORS
Synonym: Neuroendocrine Neoplasm
Synonym: Neuroendocrine Tumor
Synonym: Neuroendocrine Tumors
Synonym: Neuroendocrine Tumors [Disease/Finding]
Synonym: Neuroendocrine neoplasia
Synonym: Neuroendocrine neoplasm (morphologic abnormality)
Synonym: Neuroendocrine tumor
Synonym: Neuroendocrine tumor (disorder)
Synonym: Neuroendocrine tumor NOS
Tree Number: T3.12.14.4
database_cross_reference: CHV:0000021067
database_cross_reference: CHV:0000056678
database_cross_reference: DO:DOID:169
database_cross_reference: HPO:HP:0100634
database_cross_reference: ICD10CM:D3A.8
database_cross_reference: ICD9CM:209
database_cross_reference: ICD9CM:209-209.99
database_cross_reference: LCH_NW:sh94005134
database_cross_reference: MDR:10052399
database_cross_reference: MDR:10062476
database_cross_reference: MEDCIN:352608
database_cross_reference: MSH:D018358
database_cross_reference: MTHICD9:209.60
database_cross_reference: NCI:C3809
database_cross_reference: NCI_NCI-GLOSS:CDR0000044904
database_cross_reference: NCI_NICHD:C3809
database_cross_reference: NDFRT:N0000003804
database_cross_reference: RCD:X78dr
database_cross_reference: RCDAE:X78dr
database_cross_reference: SNOMEDCT_US:128928004
database_cross_reference: SNOMEDCT_US:255046005

Neoplasm of the oral cavity
type: Class
subclass of: Neoplasm by anatomical site
definition: A tumor (abnormal growth of tissue) of the oral cavity.
PMOID: PMO:00014219
Subclass_of: Neoplasm by anatomical site
Synonym: Lip and Oral Cavity Neoplasm
Synonym: Lip and Oral Cavity Tumor
Synonym: Lip and Oral Cavity Tumour
Synonym: MOUTH NEOPL
Synonym: MOUTH NEOPLASIA
Synonym: MOUTH TUMOR
Synonym: Mouth Neoplasm
Synonym: Mouth Neoplasms
Synonym: Mouth Neoplasms [Disease/Finding]
Synonym: Mouth Tumor
Tree Number: T3.25.1.7
database_cross_reference: AOD:0000023042
database_cross_reference: AOD:0000023043
database_cross_reference: AOD:0000023044
database_cross_reference: CHV:0000008288
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2013-2197
database_cross_reference: CST:NEOPL MOUTH
database_cross_reference: DXP:U002644
database_cross_reference: HPO:HP:0012290
database_cross_reference: HPO:HP:0100649
database_cross_reference: LCH_NW:sh85088004
database_cross_reference: MDR:10028029
database_cross_reference: MDR:10028999
database_cross_reference: MDR:10029001
database_cross_reference: MDR:10031008
database_cross_reference: MDR:10061325
database_cross_reference: MEDCIN:97905
database_cross_reference: MSH:D009062
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C7606
database_cross_reference: NCI:C8989
database_cross_reference: NDFRT:N0000002037
database_cross_reference: RCD:X20Rh
database_cross_reference: RCDAE:X20Rh
database_cross_reference: SNOMEDCT_US:126797001
database_cross_reference: SNOMEDCT_US:235075007
database_cross_reference: SNOMEDCT_VET:235075007

Type I diabetes mellitus
type: Class
subclass of: Diabetes mellitus
definition: A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin.
PMOID: PMO:00006369
Subclass_of: Diabetes mellitus
Synonym: -- Diabetes Type 1
Synonym: Brittle Diabetes Mellitus
Synonym: DIABETES MELLITUS (JUVENILE ONSET)
Synonym: DIABETES MELLITUS INSULIN DEPENDENT
Synonym: DIABETES MELLITUS TYPE 01
Synonym: DIABETES MELLITUS, INSULIN DEPENDENT
Synonym: DIABETES MELLITUS, INSULIN-DEPENDENT
Synonym: DIABETES MELLITUS, INSULIN-DEPENDENT, 1
Synonym: DIABETES MELLITUS, KETOSIS-PRONE
Synonym: DIABETES MELLITUS, TYPE 1
Tree Number: T3.12.13.4
database_cross_reference: BI:BI00334
database_cross_reference: BI:BI00335
database_cross_reference: BI:BI00338
database_cross_reference: BI:BI00363
database_cross_reference: CCPSS:1017903
database_cross_reference: CHV:0000003835
database_cross_reference: COSTAR:U000228
database_cross_reference: COSTAR:U000229
database_cross_reference: CSP:0862-6800
database_cross_reference: DO:DOID:0110748
database_cross_reference: DO:DOID:9744
database_cross_reference: DRUGBANK:DB05382
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U000471
database_cross_reference: HPO:HP:0100651
database_cross_reference: ICD10:E10
database_cross_reference: ICD10AM:E10
database_cross_reference: ICD10CM:E10
database_cross_reference: ICPC2EENG:T89
database_cross_reference: ICPC2P:T89001
database_cross_reference: ICPC2P:T89002
database_cross_reference: ICPC2P:T89003
database_cross_reference: ICPC2P:T90004
database_cross_reference: ICPC2P:T90006
database_cross_reference: ICPC2P:T90008
database_cross_reference: LNC:LA10551-2
database_cross_reference: LNC:LP36797-6
database_cross_reference: LNC:MTHU020217
database_cross_reference: MDR:10012608
database_cross_reference: MDR:10012609
database_cross_reference: MDR:10021211
database_cross_reference: MDR:10022482
database_cross_reference: MDR:10022497
database_cross_reference: MDR:10023253
database_cross_reference: MDR:10023392
database_cross_reference: MDR:10045228
database_cross_reference: MDR:10067584
database_cross_reference: MEDCIN:30481
database_cross_reference: MEDLINEPLUS:1339
database_cross_reference: MSH:D003922
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2986
database_cross_reference: NCI_NICHD:C2986
database_cross_reference: NDFRT:N0000000952
database_cross_reference: OMIM:222100
database_cross_reference: OMIM:612227
database_cross_reference: OMIM:MTHU006777
database_cross_reference: OMIM:MTHU007813
database_cross_reference: OMIM:MTHU012236
database_cross_reference: OMIM:MTHU013561
database_cross_reference: OMIM:MTHU023582
database_cross_reference: OMIM:MTHU047431
database_cross_reference: RCD:X40J4
database_cross_reference: SNM:D-2387
database_cross_reference: SNM:D-241X
database_cross_reference: SNMI:DB-61010
database_cross_reference: SNOMEDCT_US:154673001
database_cross_reference: SNOMEDCT_US:190322003
database_cross_reference: SNOMEDCT_US:190362004
database_cross_reference: SNOMEDCT_US:267469001
database_cross_reference: SNOMEDCT_US:46635009

Cellulitis
type: Class
subclass of: Abnormality of connective tissue
definition: A bacterial infection and inflammation of the skin und subcutaneous tissues.
PMOID: PMO:00001309
Subclass_of: Abnormality of connective tissue
Synonym: CELLULITIS
Synonym: Cellulitis (disorder)
Synonym: Cellulitis (morphologic abnormality)
Synonym: Cellulitis NOS
Synonym: Cellulitis NOS (disorder)
Synonym: Cellulitis [Disease/Finding]
Synonym: Cellulitis, NOS
Synonym: Cellulitis, unspecified
Synonym: Inflammation of subcutaneous tissue
Synonym: Subcutaneous tissue inflamed
Tree Number: T3.3.4
database_cross_reference: AOD:0000023000
database_cross_reference: CCPSS:1017421
database_cross_reference: CHV:0000002607
database_cross_reference: COSTAR:163
database_cross_reference: CSP:0729-7208
database_cross_reference: CSP:0944-6244
database_cross_reference: CST:CELLULITIS
database_cross_reference: DO:DOID:3488
database_cross_reference: DXP:U000311
database_cross_reference: DXP:U000578
database_cross_reference: HPO:HP:0100658
database_cross_reference: ICD10:L03
database_cross_reference: ICD10:L03.9
database_cross_reference: ICD10AM:L03
database_cross_reference: ICD10AM:L03.9
database_cross_reference: ICD10CM:L03.90
database_cross_reference: ICPC2P:S10002
database_cross_reference: ICPC2P:S76005
database_cross_reference: LCH:U000875
database_cross_reference: LCH_NW:sh85021701
database_cross_reference: MDR:10007882
database_cross_reference: MEDCIN:30907
database_cross_reference: MEDLINEPLUS:1227
database_cross_reference: MSH:D002481
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:682.9
database_cross_reference: NCI:C26715
database_cross_reference: NCI_FDA:1768
database_cross_reference: NCI_NCI-GLOSS:CDR0000044789
database_cross_reference: NCI_NICHD:C26715
database_cross_reference: NDFRT:N0000000707
database_cross_reference: OMIM:MTHU034281
database_cross_reference: RCD:M03z0
database_cross_reference: SNM:M-40200
database_cross_reference: SNMI:M-41650
database_cross_reference: SNOMEDCT_US:128045006
database_cross_reference: SNOMEDCT_US:156317003
database_cross_reference: SNOMEDCT_US:191132005
database_cross_reference: SNOMEDCT_US:200693005
database_cross_reference: SNOMEDCT_US:385627004
database_cross_reference: SNOMEDCT_US:74276003
database_cross_reference: SNOMEDCT_VET:128045006

Abnormal Sharpey fiber morphology
type: Class
subclass of: Abnormality of connective tissue
definition: An abnormality of Sharpey's fibers (bone fibers, or perforating fibers), which are a matrix of connective tissue consisting of bundles of strong collagenous fibres connecting periosteum to bone.
PMOID: PMO:00001306
Subclass_of: Abnormality of connective tissue
Tree Number: T3.3.2

Enthesitis
type: Class
subclass of: Abnormal Sharpey fiber morphology
PMOID: PMO:00001307
Subclass_of: Abnormal Sharpey fiber morphology
Synonym: Enthesitis (disorder)
Synonym: Inflammation of sharpey fibers
Synonym: enthesitis
Tree Number: T3.3.2.1
database_cross_reference: CHV:0000057176
database_cross_reference: HPO:HP:0100686
database_cross_reference: ICPC2P:L87021
database_cross_reference: MDR:10058497
database_cross_reference: NCI:C114470
database_cross_reference: NCI_NICHD:C114470
database_cross_reference: RCD:Xa0lk
database_cross_reference: SNOMEDCT_US:359643005

Scarring
type: Class
subclass of: Abnormality of connective tissue
PMOID: PMO:00001363
Subclass_of: Abnormality of connective tissue
Synonym: Cicatrisation
Synonym: Cicatrization
Synonym: Healing scar
Synonym: SKIN SCARRING
Synonym: Scarred
Synonym: Scarring (morphologic abnormality)
Synonym: cicatrisation
Synonym: cicatrization
Synonym: healing scar
Synonym: healing scars
Tree Number: T3.3.10
database_cross_reference: AOD:0000001779
database_cross_reference: CHV:0000011072
database_cross_reference: CHV:0000024542
database_cross_reference: DXP:U003692
database_cross_reference: HPO:HP:0100699
database_cross_reference: LNC:LA19047-2
database_cross_reference: LNC:LA7471-1
database_cross_reference: MSH:D002921
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X78zr
database_cross_reference: SNMI:M-78290
database_cross_reference: SNOMEDCT_US:123121007
database_cross_reference: SNOMEDCT_US:48677004

Mediastinal lymphadenopathy
type: Class
subclass of: Abnormality of the mediastinum
definition: Swelling of lymph nodes within the mediastinum, the central compartment of the thoracic cavities that contains the heart and the great vessels, the esophagus, and trachea and other structures including lymph nodes.
PMOID: PMO:00014017
Subclass_of: Abnormality of the mediastinum
Synonym: Enlargement of mediastinal lymph node
Synonym: Lymphadenopathy mediastinal
Synonym: MEDIASTINAL LYMPH NODE ENLARGEMENT
Synonym: MEDIASTINAL LYMPHADENOPATHY
Synonym: Mediastinal lymphadenopathy (disorder)
Synonym: lymphadenopathy mediastinal
Synonym: mediastinal lymphadenopathy
Tree Number: T3.21.1.1
database_cross_reference: CCPSS:0025172
database_cross_reference: CHV:0000037782
database_cross_reference: DXP:U002532
database_cross_reference: HPO:HP:0100721
database_cross_reference: MDR:10025205
database_cross_reference: MDR:10027075
database_cross_reference: SNMI:DC-72330
database_cross_reference: SNOMEDCT_US:52324001
database_cross_reference: SNOMEDCT_VET:52324001

Hypercoagulability
type: Class
subclass of: Abnormality of coagulation
definition: An abnormality of coagulation associated with an increased risk of thrombosis.
PMOID: PMO:00001211
Subclass_of: Abnormality of coagulation
Synonym: Blood hyperviscosity
Synonym: Excessive Blood Clotting
Synonym: HYPERCOAGULABLE STATE
Synonym: HYPERCOAGULATION
Synonym: Hypercoaguability
Synonym: Hypercoagulabilities
Synonym: Hypercoagulability State
Synonym: Hypercoagulability state
Synonym: Hypercoagulability state (finding)
Synonym: Hypercoagulability state, NOS
Tree Number: T3.2.8.3
database_cross_reference: CCPSS:0026526
database_cross_reference: CHV:0000032391
database_cross_reference: CHV:0000038554
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:COAGUL DIS
database_cross_reference: DO:DOID:2452
database_cross_reference: HPO:HP:0100724
database_cross_reference: ICD10CM:D68.59
database_cross_reference: MDR:10020608
database_cross_reference: MDR:10057396
database_cross_reference: MDR:10075816
database_cross_reference: MEDCIN:313610
database_cross_reference: MEDLINEPLUS:6076
database_cross_reference: MSH:D019851
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C84479
database_cross_reference: NCI_NICHD:C84479
database_cross_reference: NDFRT:N0000003961
database_cross_reference: OMIM:MTHU054815
database_cross_reference: RCD:X20Ej
database_cross_reference: SNM:F-54360
database_cross_reference: SNMI:F-D0750
database_cross_reference: SNOMEDCT_US:191302007
database_cross_reference: SNOMEDCT_US:234467004
database_cross_reference: SNOMEDCT_US:76612001

Neoplasm of the parathyroid gland
type: Class
subclass of: Neoplasm of the endocrine system
definition: A tumor (abnormal growth of tissue) of the parathyroid gland.
PMOID: PMO:00006374
Subclass_of: Neoplasm of the endocrine system
Synonym: NEOPL PARATHYROID
Synonym: Neoplasm of Parathyroid
Synonym: Neoplasm of Parathyroid Gland
Synonym: Neoplasm of parathyroid gland
Synonym: Neoplasm of parathyroid gland (disorder)
Synonym: Neoplasm of the Parathyroid
Synonym: Neoplasm of the Parathyroid Gland
Synonym: Neoplasm, Parathyroid
Synonym: Neoplasms, Parathyroid
Synonym: PARATHYROID NEOPL
Tree Number: T3.12.14.2
database_cross_reference: CHV:0000009303
database_cross_reference: CSP:2009-6398
database_cross_reference: DO:DOID:1540
database_cross_reference: HPO:HP:0100733
database_cross_reference: LCH_NW:sh85097937
database_cross_reference: MDR:10033962
database_cross_reference: MDR:10033963
database_cross_reference: MDR:10033966
database_cross_reference: MEDCIN:31622
database_cross_reference: MSH:D010282
database_cross_reference: NCI:C3313
database_cross_reference: NDFRT:N0000002322
database_cross_reference: RCD:X40KV
database_cross_reference: RCDAE:X40KV
database_cross_reference: SNOMEDCT_US:127020005

Vascular neoplasm
type: Class
subclass of: Neoplasm by anatomical site
definition: A benign or malignant neoplasm (tumour) originating in the vascular system.
PMOID: PMO:00014269
Subclass_of: Neoplasm by anatomical site
Synonym: Blood Vessel neoplasm
Synonym: Blood vessel tumor
Synonym: Blood vessel tumors
Synonym: Blood vessel tumour disorder
Synonym: Haemangiomatous tumour
Synonym: NEOPL VASCULAR
Synonym: Neoplasm of Vascular Tissue
Synonym: Neoplasm, Vascular
Synonym: Neoplasms, Vascular
Synonym: Tumor of Vascular Tissue
Tree Number: T3.25.1.13
database_cross_reference: CHV:0000027665
database_cross_reference: DO:DOID:175
database_cross_reference: HPO:HP:0100742
database_cross_reference: MDR:10055031
database_cross_reference: MDR:10057189
database_cross_reference: MSH:D019043
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C7388
database_cross_reference: NCI_CTEP-SDC:10055031
database_cross_reference: NDFRT:N0000003887

Chest pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
PMOID: PMO:00014087
Subclass_of: Pain
Synonym: CHEST PAIN
Synonym: Chest Pain
Synonym: Chest Pain [Disease/Finding]
Synonym: Chest Pains
Synonym: Chest pain (finding)
Synonym: Chest pain NOS
Synonym: Chest pain NOS (finding)
Synonym: Chest pain nos
Synonym: Chest pain, NOS
Synonym: Chest pain, unspecified
Tree Number: T3.23.10.8
database_cross_reference: BI:BI00012
database_cross_reference: CCPSS:1017850
database_cross_reference: CHV:0000002750
database_cross_reference: CHV:0000023593
database_cross_reference: COSTAR:171
database_cross_reference: CST:PAIN CHEST
database_cross_reference: DXP:U000673
database_cross_reference: HPO:HP:0100749
database_cross_reference: ICD10:R07.4
database_cross_reference: ICD10AM:R07.4
database_cross_reference: ICD10CM:R07.9
database_cross_reference: ICD9CM:786.5
database_cross_reference: ICD9CM:786.50
database_cross_reference: ICPC2EENG:A11
database_cross_reference: ICPC2P:A11001
database_cross_reference: ICPC2P:L04003
database_cross_reference: LCH:U000942
database_cross_reference: LCH_NW:sh85023146
database_cross_reference: LNC:LP98885-4
database_cross_reference: LNC:MTHU035552
database_cross_reference: MDR:10008479
database_cross_reference: MDR:10029524
database_cross_reference: MDR:10033387
database_cross_reference: MDR:10043471
database_cross_reference: MDR:10043492
database_cross_reference: MDR:10045653
database_cross_reference: MDR:10067524
database_cross_reference: MEDCIN:279
database_cross_reference: MEDCIN:281472
database_cross_reference: MEDCIN:33722
database_cross_reference: MEDLINEPLUS:4744
database_cross_reference: MSH:D002637
database_cross_reference: MTH:172
database_cross_reference: MTH:589
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38665
database_cross_reference: NCI_FDA:1776
database_cross_reference: NCI_NCI-GLOSS:CDR0000449748
database_cross_reference: NCI_NCI-GLOSS:CDR0000467223
database_cross_reference: NCI_NICHD:C38665
database_cross_reference: NDFRT:N0000000746
database_cross_reference: OMIM:MTHU018205
database_cross_reference: OMIM:MTHU025178
database_cross_reference: RCD:182..
database_cross_reference: RCD:182Z.
database_cross_reference: RCD:R065.
database_cross_reference: RCD:R065z
database_cross_reference: RCD:XE2rt
database_cross_reference: RCDSY:R065.
database_cross_reference: RCDSY:R065z
database_cross_reference: RCDSY:XE2rt
database_cross_reference: SNM:F-71400
database_cross_reference: SNMI:F-37000
database_cross_reference: SNOMEDCT_US:139228007
database_cross_reference: SNOMEDCT_US:139240007
database_cross_reference: SNOMEDCT_US:158393008
database_cross_reference: SNOMEDCT_US:158404009
database_cross_reference: SNOMEDCT_US:161978005
database_cross_reference: SNOMEDCT_US:207078009
database_cross_reference: SNOMEDCT_US:207079001
database_cross_reference: SNOMEDCT_US:207093008
database_cross_reference: SNOMEDCT_US:271330001
database_cross_reference: SNOMEDCT_US:29857009
database_cross_reference: SNOMEDCT_VET:29857009

Gangrene
type: Class
subclass of: Constitutional symptom
definition: A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).
PMOID: PMO:00014060
Subclass_of: Constitutional symptom
Synonym: 546 GANGRENES
Synonym: GANGRENE
Synonym: GANGRENES
Synonym: Gangrene (disorder)
Synonym: Gangrene (morphologic abnormality)
Synonym: Gangrene NOS
Synonym: Gangrene [Disease/Finding]
Synonym: Gangrene, NOS
Synonym: Gangrenes
Synonym: Gangrenous
Tree Number: T3.23.6
database_cross_reference: AOD:0000004489
database_cross_reference: CCPSS:1017512
database_cross_reference: CHV:0000005347
database_cross_reference: COSTAR:U000312
database_cross_reference: CSP:0944-7081
database_cross_reference: CST:GANGRENE
database_cross_reference: DXP:U001639
database_cross_reference: HPO:HP:0100758
database_cross_reference: ICD9CM:785.4
database_cross_reference: ICPC2P:K92004
database_cross_reference: LCH:U001915
database_cross_reference: LCH_NW:sh85053025
database_cross_reference: MDR:10017711
database_cross_reference: MDR:10017718
database_cross_reference: MEDCIN:30967
database_cross_reference: MEDCIN:6245
database_cross_reference: MEDLINEPLUS:5580
database_cross_reference: MSH:D005734
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:785.4
database_cross_reference: NCI:C50573
database_cross_reference: NCI_FDA:1873
database_cross_reference: NDFRT:N0000001309
database_cross_reference: OMIM:MTHU037861
database_cross_reference: RCD:R054.
database_cross_reference: RCD:R054z
database_cross_reference: RCD:XM07q
database_cross_reference: RCDSY:R054.
database_cross_reference: RCDSY:R054z
database_cross_reference: SNM:M-54600
database_cross_reference: SNM:U000349
database_cross_reference: SNMI:M-54600
database_cross_reference: SNOMEDCT_US:158349008
database_cross_reference: SNOMEDCT_US:158352000
database_cross_reference: SNOMEDCT_US:207019006
database_cross_reference: SNOMEDCT_US:207024009
database_cross_reference: SNOMEDCT_US:263765007
database_cross_reference: SNOMEDCT_US:36024000
database_cross_reference: SNOMEDCT_US:372070002

Abnormality of the lymphatic system
type: Class
subclass of: Abnormality of the immune system
definition: An anomaly of the lymphatic system, a network of lymphatic vessels that carry a clear fluid called lymph unidirectionally towards either the right lymphatic duct or the thoracic duct, which in turn drain into the right and left subclavian veins respectively.
PMOID: PMO:00008685
Subclass_of: Abnormality of the immune system
Tree Number: T3.15.3
database_cross_reference: HPO:HP:0100763

Lymphangioma
type: Class
subclass of: Abnormality of the lymphatic system
definition: Lymphangiomas are rare congenital malformations consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures. Lymphangioma is usually asymptomatic due to its soft consistency but compression of adjacent structures can be seen due to the mass effect of a large tumor.
PMOID: PMO:00008728
Subclass_of: Abnormality of the lymphatic system
Synonym: Benign lymphangioma
Synonym: Benign lymphangioma (morphologic abnormality)
Synonym: Congenital lymphangioma
Synonym: Congenital lymphangioma (disorder)
Synonym: LYMPHANGIOMA
Synonym: LYMPHANGIOMA, BENIGN
Synonym: Lymphangioma (disorder)
Synonym: Lymphangioma NOS
Synonym: Lymphangioma [Disease/Finding]
Synonym: Lymphangioma morphology
Tree Number: T3.15.3.5
database_cross_reference: CCPSS:1006008
database_cross_reference: CHV:0000007598
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:2004-0139
database_cross_reference: DO:DOID:1475
database_cross_reference: HPO:HP:0100764
database_cross_reference: ICD10:D18.1
database_cross_reference: ICD10AM:D18.1
database_cross_reference: ICD10AM:M9170/0
database_cross_reference: ICD10CM:D18.1
database_cross_reference: ICD9CM:228.1
database_cross_reference: ICPC2P:K72007
database_cross_reference: ICPC2P:K99046
database_cross_reference: MDR:10025219
database_cross_reference: MDR:10025220
database_cross_reference: MEDCIN:30773
database_cross_reference: MSH:D008202
database_cross_reference: MTHICD9:228.1
database_cross_reference: NCI:C8965
database_cross_reference: NCI_CDISC:C8965
database_cross_reference: NCI_NICHD:C8965
database_cross_reference: NDFRT:N0000001894
database_cross_reference: OMIM:MTHU015908
database_cross_reference: RCD:BBU0.
database_cross_reference: RCD:X77p7
database_cross_reference: RCD:X78WK
database_cross_reference: RCD:Xa9AT
database_cross_reference: RCDSY:BBU0.
database_cross_reference: SNM:M-9170/0
database_cross_reference: SNMI:D3-F0700
database_cross_reference: SNMI:M-91700
database_cross_reference: SNOMEDCT_US:154625006
database_cross_reference: SNOMEDCT_US:189200000
database_cross_reference: SNOMEDCT_US:189875000
database_cross_reference: SNOMEDCT_US:253057002
database_cross_reference: SNOMEDCT_US:254836000
database_cross_reference: SNOMEDCT_US:269646001
database_cross_reference: SNOMEDCT_US:400178008
database_cross_reference: SNOMEDCT_US:69044001
database_cross_reference: SNOMEDCT_US:93168006

Abnormality of the tonsils
type: Class
subclass of: Abnormality of the lymphatic system
definition: An abnormality of the tonsils.
PMOID: PMO:00008715
Subclass_of: Abnormality of the lymphatic system
Tree Number: T3.15.3.4
database_cross_reference: HPO:HP:0100765

Abnormality of the placenta
type: Class
subclass of: Abnormalities of placenta or umbilical cord
definition: An abnormality of the placenta, the organ that connects the developing fetus to the uterine wall to enable nutrient uptake, waste elimination, and gas exchange.
PMOID: PMO:00004318
Subclass_of: Abnormalities of placenta or umbilical cord
Synonym: 4-F3 ANOMALIES OF THE PLACENTA
Synonym: ANOMALIES OF THE PLACENTA
Synonym: Abnormal placenta
Synonym: Abnormal placenta NOS
Synonym: Abnormal placenta, NOS
Synonym: Abnormalities of Placenta
Synonym: Anomaly of placenta
Synonym: Anomaly of placenta (disorder)
Synonym: Anomaly of placenta, NOS
Synonym: PLACENTA ABNORMAL
Tree Number: T3.7.2.2
database_cross_reference: CCPSS:0023921
database_cross_reference: CHV:0000057943
database_cross_reference: COSTAR:NOCODE
database_cross_reference: HPO:HP:0100767
database_cross_reference: ICD10CM:O43.10
database_cross_reference: RCD:63D5.
database_cross_reference: SNM:M-29000
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:D4-F3000
database_cross_reference: SNOMEDCT_US:147190007
database_cross_reference: SNOMEDCT_US:169957005
database_cross_reference: SNOMEDCT_US:33552005

Hyperostosis
type: Class
subclass of: Abnormality of skeletal morphology
definition: Excessive growth or abnormal thickening of bone tissue.
PMOID: PMO:00013954
Subclass_of: Abnormality of skeletal morphology
Synonym: Bone Hypertrophies
Synonym: Bone Hypertrophy
Synonym: Bone hypertrophy
Synonym: Bone overgrowth
Synonym: Bony overgrowth
Synonym: HYPEROSTOSIS
Synonym: Hyperostoses
Synonym: Hyperostosis [Disease/Finding]
Synonym: Hyperostosis, NOS
Synonym: Hypertrophies, Bone
Tree Number: T3.20.1.12
database_cross_reference: CHV:0000006426
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CST:BONE DIS
database_cross_reference: DO:DOID:205
database_cross_reference: HPO:HP:0100774
database_cross_reference: ICD10:M89.3
database_cross_reference: ICD10AM:M89.3
database_cross_reference: ICD10AM:M89.39
database_cross_reference: ICD10CM:M89.3
database_cross_reference: ICD10CM:M89.30
database_cross_reference: MDR:10005973
database_cross_reference: MDR:10020698
database_cross_reference: MEDCIN:272981
database_cross_reference: MSH:D015576
database_cross_reference: MTHICD9:733.99
database_cross_reference: NCI:C34712
database_cross_reference: NDFRT:N0000003289
database_cross_reference: OMIM:MTHU036636
database_cross_reference: RCD:N33z4
database_cross_reference: SNM:M-71430
database_cross_reference: SNM:M-71450
database_cross_reference: SNMI:M-71430
database_cross_reference: SNOMEDCT_US:13814009
database_cross_reference: SNOMEDCT_US:203514008

Hernia
type: Class
subclass of: Abnormality of connective tissue
PMOID: PMO:00001348
Subclass_of: Abnormality of connective tissue
Synonym: HERNIA
Synonym: HERNIATION
Synonym: Hernia (K40-K46)
Synonym: Hernia (morphologic abnormality)
Synonym: Hernia - lesion
Synonym: Hernia - lesion (qualifier value)
Synonym: Hernia NOS
Synonym: Hernia [Disease/Finding]
Synonym: Hernia, NOS
Synonym: Hernias
Tree Number: T3.3.7
database_cross_reference: AOD:0000004460
database_cross_reference: BI:BI00271
database_cross_reference: CCPSS:0022658
database_cross_reference: CCPSS:1006190
database_cross_reference: CHV:0000006079
database_cross_reference: COSTAR:360
database_cross_reference: CSP:0944-5779
database_cross_reference: CST:HERNIA
database_cross_reference: HPO:HP:0100790
database_cross_reference: ICD10:K40-K46.9
database_cross_reference: ICD10AM:K40-K46.9
database_cross_reference: ICD10CM:K40-K46
database_cross_reference: ICD10CM:K46
database_cross_reference: ICPC2P:D91001
database_cross_reference: LCH:U002183
database_cross_reference: LCH_NW:sh85060424
database_cross_reference: MDR:10019909
database_cross_reference: MDR:10019918
database_cross_reference: MEDCIN:96160
database_cross_reference: MEDLINEPLUS:283
database_cross_reference: MSH:D006547
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34685
database_cross_reference: NCI_CDISC:C34685
database_cross_reference: NCI_FDA:2240
database_cross_reference: NCI_NCI-GLOSS:CDR0000630906
database_cross_reference: NCI_NICHD:C34685
database_cross_reference: NDFRT:N0000001516
database_cross_reference: OMIM:MTHU012924
database_cross_reference: OMIM:MTHU014363
database_cross_reference: RCD:J3...
database_cross_reference: RCD:Jyu3.
database_cross_reference: RCD:Xa0FV
database_cross_reference: RCDSY:Jyu3.
database_cross_reference: SNM:M-31600
database_cross_reference: SNM:M-31650
database_cross_reference: SNM:U000294
database_cross_reference: SNMI:M-31500
database_cross_reference: SNOMEDCT_US:14778003
database_cross_reference: SNOMEDCT_US:197529008
database_cross_reference: SNOMEDCT_US:276915000
database_cross_reference: SNOMEDCT_US:359801000
database_cross_reference: SNOMEDCT_US:362633009
database_cross_reference: SNOMEDCT_US:414403008
database_cross_reference: SNOMEDCT_US:52515009

Sepsis
type: Class
subclass of: Abnormality of immune system physiology
definition: Systemic inflammatory response to infection.
PMOID: PMO:00008683
Subclass_of: Abnormality of immune system physiology
Synonym: (Septicaemia NOS) or (sepsis)
Synonym: (Septicaemia NOS) or (sepsis) (disorder)
Synonym: (Septicemia NOS) or (sepsis)
Synonym: BLOOD POIS
Synonym: BLOOD POISONING
Synonym: Blood Poisoning
Synonym: Blood Poisonings
Synonym: Blood poisoning
Synonym: Blood poisoning, NOS
Synonym: POIS BLOOD
Tree Number: T3.15.2.15
database_cross_reference: AOD:0000004501
database_cross_reference: AOD:0000023002
database_cross_reference: CCPSS:1009808
database_cross_reference: CHV:0000011211
database_cross_reference: COSTAR:U000614
database_cross_reference: CSP:0456-1801
database_cross_reference: CSP:5003-0039
database_cross_reference: CST:SEPSIS
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U001730
database_cross_reference: DXP:U003496
database_cross_reference: HPO:HP:0100806
database_cross_reference: ICD10:A41.9
database_cross_reference: ICD10AM:A41.9
database_cross_reference: ICD10AMAE:A41.9
database_cross_reference: ICD10CM:A41.9
database_cross_reference: ICD9CM:038
database_cross_reference: ICD9CM:038.9
database_cross_reference: ICPC2P:A78006
database_cross_reference: ICPC2P:A78023
database_cross_reference: LCH:U004268
database_cross_reference: LCH_NW:sh85120119
database_cross_reference: LNC:MTHU020833
database_cross_reference: MDR:10040072
database_cross_reference: MDR:10040082
database_cross_reference: MDR:10040089
database_cross_reference: MDR:10046161
database_cross_reference: MDR:10060437
database_cross_reference: MEDCIN:30873
database_cross_reference: MEDLINEPLUS:3210
database_cross_reference: MSH:D018805
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:038.9
database_cross_reference: NCI:C3364
database_cross_reference: NCI_CTCAE:E11560
database_cross_reference: NCI_FDA:2067
database_cross_reference: NCI_NCI-GLOSS:CDR0000044348
database_cross_reference: NCI_NCI-GLOSS:CDR0000045088
database_cross_reference: NCI_NCI-GLOSS:CDR0000476299
database_cross_reference: NCI_NCI-GLOSS:CDR0000476300
database_cross_reference: NCI_NICHD:C3364
database_cross_reference: NDFRT:N0000002716
database_cross_reference: OMIM:MTHU043659
database_cross_reference: RCD:A38..
database_cross_reference: RCD:Ayu3J
database_cross_reference: RCD:XE0Qx
database_cross_reference: RCDAE:A38..
database_cross_reference: RCDAE:Ayu3J
database_cross_reference: RCDAE:XE0Qx
database_cross_reference: RCDSY:Ayu3J
database_cross_reference: SNM:D-0080
database_cross_reference: SNMI:DD-80060
database_cross_reference: SNMI:DE-00020
database_cross_reference: SNOMEDCT_US:105592009
database_cross_reference: SNOMEDCT_US:154313001
database_cross_reference: SNOMEDCT_US:186392004
database_cross_reference: SNOMEDCT_US:187333004
database_cross_reference: SNOMEDCT_US:266089004
database_cross_reference: SNOMEDCT_US:40555009
database_cross_reference: SNOMEDCT_US:91302008

Genital hernia
type: Class
subclass of: Hernia
PMOID: PMO:00001353
Subclass_of: Hernia
Tree Number: T3.3.7.2
database_cross_reference: HPO:HP:0100823

Galactorrhea
type: Class
subclass of: Abnormal breast physiology
definition: Spontaneous flow of milk from the breast, unassociated with childbirth or nursing.
PMOID: PMO:00004440
Subclass_of: Abnormal breast physiology
Synonym: GALACTORRHEA
Synonym: GALACTORRHEA FEMALE
Synonym: GALACTORRHEA NONOBSTETRIC
Synonym: Galactorrhea - non-obstetric
Synonym: Galactorrhea due to non-obstetric cause
Synonym: Galactorrhea due to non-obstetric cause (disorder)
Synonym: Galactorrhea female
Synonym: Galactorrhea not associated with childbirth
Synonym: Galactorrhea not associated with childbirth (disorder)
Synonym: Galactorrhea, NOS
Tree Number: T3.8.2.2
database_cross_reference: CCPSS:0002686
database_cross_reference: CST:LACTATION FEM
database_cross_reference: DO:DOID:10689
database_cross_reference: ICD10:N64.3
database_cross_reference: ICD10AM:N64.3
database_cross_reference: ICD10AMAE:N64.3
database_cross_reference: ICD10CM:N64.3
database_cross_reference: ICD9CM:611.6
database_cross_reference: MDR:10017594
database_cross_reference: MDR:10017595
database_cross_reference: MDR:10017600
database_cross_reference: MDR:10017603
database_cross_reference: MDR:10023668
database_cross_reference: MDR:10023669
database_cross_reference: MDR:10073888
database_cross_reference: MEDCIN:35161
database_cross_reference: MSH:C537072
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU053309
database_cross_reference: RCD:K316.
database_cross_reference: RCD:XM0B1
database_cross_reference: RCDAE:K316.
database_cross_reference: RCDAE:XM0B1
database_cross_reference: SNM:F-31923
database_cross_reference: SNMI:D7-90444
database_cross_reference: SNOMEDCT_US:198115002
database_cross_reference: SNOMEDCT_US:78622004

Abnormality of vitamin K metabolism
type: Class
subclass of: Abnormality of vitamin metabolism
definition: Vitamin K is a fat-soluble vitamin with a role in promoting the coagulation cascade.
PMOID: PMO:00004235
Subclass_of: Abnormality of vitamin metabolism
Tree Number: T3.6.23.6
database_cross_reference: HPO:HP:0100831

Hypoplastic areola
type: Class
subclass of: Abnormal breast morphology
definition: Underdevelopment of the areola, the circular area of pigmented skin surrounding the nipple.
PMOID: PMO:00004437
Subclass_of: Abnormal breast morphology
Synonym: Hypoplastic areolae
Tree Number: T3.8.1.6
database_cross_reference: HPO:HP:0100853

Congenital mesoblastic nephroma
type: Class
subclass of: Abnormality of connective tissue
definition: Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by ultrasound or within the first 3 months of life. It contains fibroblastic cells (connective tissue cells), and may spread to the other kidney or to nearby tissue.
PMOID: PMO:00001310
Subclass_of: Abnormality of connective tissue
Synonym: CMN
Synonym: CONGEN MESOBLASTIC NEPHROMA
Synonym: Cmn
Synonym: Congenital Mesoblastic Nephroma
Synonym: Congenital Mesoblastic Nephromas
Synonym: Mesoblastic Nephroma
Synonym: Mesoblastic Nephroma, Congenital
Synonym: Mesoblastic Nephromas, Congenital
Synonym: Nephroma, Congenital Mesoblastic
Synonym: Nephromas, Congenital Mesoblastic
Tree Number: T3.3.5
database_cross_reference: DO:DOID:4773
database_cross_reference: HPO:HP:0100881
database_cross_reference: MSH:D018201
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C6569
database_cross_reference: NCI_CDISC:C6569
database_cross_reference: NCI_NCI-GLOSS:CDR0000534218
database_cross_reference: NCI_NICHD:C6569

Abnormality of globe location
type: Class
subclass of: Abnormal eye morphology
definition: An abnormality in the placement of the ocular globe (eyeball).
PMOID: PMO:00006953
Subclass_of: Abnormal eye morphology
Synonym: Abnormality of eyeball location
Synonym: Abnormality of eyeball position
Synonym: Abnormality of globe position
Tree Number: T3.13.1.5
database_cross_reference: HPO:HP:0100886

Abnormality of globe size
type: Class
subclass of: Abnormal eye morphology
definition: An abnormality in the size of the ocular globe (eyeball).
PMOID: PMO:00006961
Subclass_of: Abnormal eye morphology
Synonym: Abnormality of eyeball size
Tree Number: T3.13.1.6
database_cross_reference: HPO:HP:0100887

Neoplasm of fatty tissue
type: Class
subclass of: Abnormal adipose tissue morphology
definition: A tumor (abnormal growth of tissue) of adipose tissue.
PMOID: PMO:00001295
Subclass_of: Abnormal adipose tissue morphology
Synonym: Tumor of fatty tissue
Tree Number: T3.3.1.9
database_cross_reference: HPO:HP:0200013

Mandibular pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the mandible.
PMOID: PMO:00014103
Subclass_of: Pain
Synonym: Gnathodynia
Synonym: JAW BONE PAIN
Synonym: JAW PAIN
Synonym: Jaw bone pain
Synonym: Jaw pain
Synonym: Jaw pain (finding)
Synonym: Lower jaw pain
Synonym: MANDIBULAR PAIN
Synonym: PAIN JAW
Synonym: Pain in jaw
Tree Number: T3.23.10.22
database_cross_reference: CCPSS:0025667
database_cross_reference: CHV:0000018291
database_cross_reference: CHV:0000023658
database_cross_reference: CST:PAIN
database_cross_reference: CST:PAIN BONE
database_cross_reference: DXP:U002205
database_cross_reference: DXP:U002501
database_cross_reference: HPO:HP:0040264
database_cross_reference: HPO:HP:0200025
database_cross_reference: ICD10CM:R68.84
database_cross_reference: ICD9CM:784.92
database_cross_reference: ICPC2P:L07001
database_cross_reference: MDR:10023143
database_cross_reference: MDR:10023157
database_cross_reference: MDR:10033433
database_cross_reference: MDR:10033455
database_cross_reference: MDR:10072238
database_cross_reference: MEDCIN:181
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:784.92
database_cross_reference: OMIM:MTHU036747
database_cross_reference: RCD:XM1B6
database_cross_reference: RCD:Xa8IQ
database_cross_reference: RCDSY:Xa8IQ
database_cross_reference: SNMI:D5-14010
database_cross_reference: SNOMEDCT_US:206948006
database_cross_reference: SNOMEDCT_US:274667000
database_cross_reference: SNOMEDCT_US:302241006
database_cross_reference: SNOMEDCT_US:95523006

Ocular pain
type: Class
subclass of: Pain
definition: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye.
PMOID: PMO:00014108
Subclass_of: Pain
Synonym: EYE PAIN
Synonym: Eye Pain
Synonym: Eye Pain [Disease/Finding]
Synonym: Eye Pains
Synonym: Eye ache
Synonym: Eye pain
Synonym: Eye pain NOS
Synonym: Eye pain NOS (finding)
Synonym: Eye painful
Synonym: OCULAR PAIN
Tree Number: T3.23.10.25
database_cross_reference: CCPSS:1015742
database_cross_reference: CHV:0000017081
database_cross_reference: COSTAR:531
database_cross_reference: CST:PAIN EYE
database_cross_reference: DXP:U001322
database_cross_reference: HPO:HP:0200026
database_cross_reference: ICD10:H57.1
database_cross_reference: ICD10AM:H57.1
database_cross_reference: ICD10CM:H57.1
database_cross_reference: ICD10CM:H57.10
database_cross_reference: ICPC2EENG:F01
database_cross_reference: ICPC2P:F01001
database_cross_reference: MDR:10015906
database_cross_reference: MDR:10015958
database_cross_reference: MDR:10033397
database_cross_reference: MDR:10033426
database_cross_reference: MDR:10067261
database_cross_reference: MEDCIN:115
database_cross_reference: MSH:D058447
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78287
database_cross_reference: NCI_CTCAE:E10376
database_cross_reference: NDFRT:N0000182163
database_cross_reference: RCD:F4Kz1
database_cross_reference: RCD:X75rH
database_cross_reference: SNMI:F-F1710
database_cross_reference: SNOMEDCT_US:139556001
database_cross_reference: SNOMEDCT_US:162286001
database_cross_reference: SNOMEDCT_US:194185002
database_cross_reference: SNOMEDCT_US:41652007
database_cross_reference: SNOMEDCT_VET:41652007

Cat cry
type: Class
subclass of: Abnormal cry
definition: The presence of a characteristic high-pitched cry that sounds similar to the meowing of a kitten.
PMOID: PMO:00014021
Subclass_of: Abnormal cry
Synonym: cat-like cry
Tree Number: T3.22.1.1
database_cross_reference: HPO:HP:0200046

Abnormality of cartilage morphology
type: Class
subclass of: Abnormality of skeletal morphology
definition: Any abnormality of cartilage.
PMOID: PMO:00013944
Subclass_of: Abnormality of skeletal morphology
Tree Number: T3.20.1.7

Abnormality of the peripheral nervous system
type: Class
subclass of: Abnormality of the nervous system
definition: Any abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord.
PMOID: PMO:00011335
Subclass_of: Abnormality of the nervous system
Tree Number: T3.18.4
database_cross_reference: HPO:HP:0410008

Abnormality of the somatic nervous system
type: Class
subclass of: Abnormality of the peripheral nervous system
definition: Any abnormality of the part of the peripheral nervous system associated with sensation and skeletal muscle voluntary control of body movements.
PMOID: PMO:00011348
Subclass_of: Abnormality of the peripheral nervous system
Tree Number: T3.18.4.2
database_cross_reference: HPO:HP:0410009

Abnormality of ganglion
type: Class
subclass of: Abnormality of the nervous system
definition: An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system.
PMOID: PMO:00009760
Subclass_of: Abnormality of the nervous system
Tree Number: T3.18.1
database_cross_reference: HPO:HP:0410014

Abnormality of ganglion of peripheral nervous system
type: Class
subclass of: Abnormality of ganglion
definition: An abnormality of nerve cell cluster or a group of nerve cell bodies located in the peripheral autonomic nervous system.
PMOID: PMO:00009763
Subclass_of: Abnormality of ganglion
Tree Number: T3.18.1.2
database_cross_reference: HPO:HP:0410015

Abnormality of cranial ganglion
type: Class
subclass of: Abnormality of ganglion
definition: An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system of the cranium.
PMOID: PMO:00009761
Subclass_of: Abnormality of ganglion
Tree Number: T3.18.1.1
database_cross_reference: HPO:HP:0410016

Epigastric pain
type: Class
subclass of: Pain
definition: Pain that is localized to the region of the upper abdomen immediately below the ribs.
PMOID: PMO:00014092
Subclass_of: Pain
Synonym: Abdmnal pain epigastric
Synonym: Abdominal pain epigastric
Synonym: Abdominal pain, epigastric
Synonym: EPIGASTRIC ABDOMINAL PAIN
Synonym: EPIGASTRIC PAIN
Synonym: Epigastralgia
Synonym: Epigastric ache
Synonym: Epigastric pain (finding)
Synonym: Epigastric pain epigastralgia
Synonym: Epigastrium pain
Tree Number: T3.23.10.13
database_cross_reference: BI:BI00241
database_cross_reference: CCPSS:1015287
database_cross_reference: CHV:0000022956
database_cross_reference: COSTAR:U000276
database_cross_reference: CST:PAIN ABDO
database_cross_reference: DXP:U001136
database_cross_reference: HPO:HP:0410019
database_cross_reference: ICD10CM:R10.13
database_cross_reference: ICD9CM:789.06
database_cross_reference: ICPC2EENG:D02
database_cross_reference: ICPC2P:D02007
database_cross_reference: ICPC2P:D02008
database_cross_reference: MDR:10015014
database_cross_reference: MDR:10015026
database_cross_reference: MDR:10015027
database_cross_reference: MDR:10033394
database_cross_reference: MDR:10048944
database_cross_reference: MEDCIN:477
database_cross_reference: OMIM:MTHU039020
database_cross_reference: RCD:1972.
database_cross_reference: RCD:R0905
database_cross_reference: RCDSY:R0905
database_cross_reference: SNMI:F-50872
database_cross_reference: SNOMEDCT_US:139318001
database_cross_reference: SNOMEDCT_US:158505007
database_cross_reference: SNOMEDCT_US:207211000
database_cross_reference: SNOMEDCT_US:79922009

Fish odor
type: Class
subclass of: Body odor
definition: Body odor characterized by an offensive body odor and the smell of rotting fish due to the excessive excretion of trimethylaminuria (TMA) in the urine, sweat, and breath of affected individuals.
PMOID: PMO:00014050
Subclass_of: Body odor
Synonym: Fish odour
Synonym: Fishy body odor
Synonym: Fishy odor
Tree Number: T3.23.2.1
database_cross_reference: HPO:HP:0410020

Musty odor
type: Class
subclass of: Body odor
definition: Pungent body odor.
PMOID: PMO:00014052
Subclass_of: Body odor
Synonym: Musty odour
Tree Number: T3.23.2.2
database_cross_reference: HPO:HP:0410021

Decreased level of 1,5 anhydroglucitol in serum
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: A decrease in the level of 1,5 anhydroglucitol in the serum. 1,5-Anhydrosorbitol is a validated marker of short-term glycemic control. This substance is derived mainly from food, is well absorbed in the intestine, and is distributed to all organs and tissues.
PMOID: PMO:00003730
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Decreased level of 1,5-AG in serum
Synonym: Decreased level of 1,5-anhydro-D-glucitol in serum
Synonym: Decreased level of 1,5-anhydroglucitol in serum
Tree Number: T3.6.10.8
database_cross_reference: HPO:HP:0410050

Increased level of allantoin in serum
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: An increase in the level of allantoin in the serum.
PMOID: PMO:00004163
Subclass_of: Abnormality of nitrogen compound homeostasis
Tree Number: T3.6.18.10
database_cross_reference: HPO:HP:0410052

Decreased level of erythritol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: A decrease in the level of erythritol in the urine.
PMOID: PMO:00003732
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.10
database_cross_reference: HPO:HP:0410055

Increased level of D-threitol in plasma
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of D-threitol in the plasma.
PMOID: PMO:00003745
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.17
database_cross_reference: HPO:HP:0410057

Increased level of D-threitol in CSF
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of D-threitol in the cerebrospinal fluid.
PMOID: PMO:00003744
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of D-threitol in cerebrospinal fluid
Tree Number: T3.6.10.16
database_cross_reference: HPO:HP:0410058

Increased level of D-threitol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of D-threitol in the urine.
PMOID: PMO:00003746
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.18
database_cross_reference: HPO:HP:0410059

Decreased level of D-mannose in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: A decrease in the level of D-mannose in the urine.
PMOID: PMO:00003731
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.9
database_cross_reference: HPO:HP:0410060

Increased level of galactitol in plasma
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of galactitol in the plasma.
PMOID: PMO:00003747
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.19
database_cross_reference: HPO:HP:0410061

Increased level of galactitol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of galactitol in the urine.
PMOID: PMO:00003749
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.21
database_cross_reference: HPO:HP:0410062

Increased level of galactonate in red blood cells
type: Class
subclass of: Abnormality of carboxylic acid metabolism
definition: An increase in the level of galactonate in the red blood cells.
PMOID: PMO:00003912
Subclass_of: Abnormality of carboxylic acid metabolism
Synonym: Increased level of galactonate in erythrocytes
Tree Number: T3.6.11.5
database_cross_reference: HPO:HP:0410063

Increased level of galactitol in red blood cells
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of galactitol in the red blood cells.
PMOID: PMO:00003748
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of galactitol in erythrocytes
Tree Number: T3.6.10.20
database_cross_reference: HPO:HP:0410064

Increased level of hippuric acid in blood
type: Class
subclass of: Abnormality of carboxylic acid metabolism
definition: An increase in the level of hippuric acid in the blood.
PMOID: PMO:00003913
Subclass_of: Abnormality of carboxylic acid metabolism
Synonym: Increased level of N-benzoylglycine in blood
Tree Number: T3.6.11.6
database_cross_reference: HPO:HP:0410065

Increased level of hippuric acid in urine
type: Class
subclass of: Abnormality of carboxylic acid metabolism
definition: An increase in the level of hippuric acid in the urine.
PMOID: PMO:00003914
Subclass_of: Abnormality of carboxylic acid metabolism
Synonym: Increased level of N-benzoylglycine in urine
Tree Number: T3.6.11.7
database_cross_reference: HPO:HP:0410066

Increased level of L-fucose in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of L-fucose in the urine.
PMOID: PMO:00003750
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.22
database_cross_reference: HPO:HP:0410067

Increased level of propylene glycol in blood
type: Class
subclass of: Abnormality of metabolism/homeostasis
definition: An increase in the level of propylene glycol in the blood.
PMOID: PMO:00004262
Subclass_of: Abnormality of metabolism/homeostasis
Synonym: Increased level of propane-1,2-diol in blood
Tree Number: T3.6.30
database_cross_reference: HPO:HP:0410069

Increased level of ribitol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of ribitol in the urine.
PMOID: PMO:00003754
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.26
database_cross_reference: HPO:HP:0410070

Increased level of ribitol in CSF
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of ribitol in the cerebral spinal fluid.
PMOID: PMO:00003753
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of ribitol in cerebrospinal fluid
Tree Number: T3.6.10.25
database_cross_reference: HPO:HP:0410071

Increased level of ribose in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of ribose in the urine.
PMOID: PMO:00003756
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.28
database_cross_reference: HPO:HP:0410072

Increased level of ribose in CSF
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of ribose in the cerebrospinal fluid.
PMOID: PMO:00003755
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of ribose in cerebrospinal fluid
Tree Number: T3.6.10.27
database_cross_reference: HPO:HP:0410073

Increased level of xylitol in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of xylitol in the urine.
PMOID: PMO:00003758
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Tree Number: T3.6.10.30
database_cross_reference: HPO:HP:0410074

Increased level of xylitol in CSF
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of xylitol in the cerebrospinal fluid.
PMOID: PMO:00003757
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of xylitol in cerebrospinal fluid
Tree Number: T3.6.10.29
database_cross_reference: HPO:HP:0410075

Abnormal biotinidase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: An abnormality in biotinidase activity, an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation.
PMOID: PMO:00003540
Subclass_of: Abnormal enzyme/coenzyme activity
Tree Number: T3.6.3.2
database_cross_reference: HPO:HP:0410144

Increased level of N-acetylneuraminic acid in urine
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of N-acetylneuraminic acid in the urine.
PMOID: PMO:00003752
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of NANA in urine
Synonym: Increased level of Neu5Ac in urine
Tree Number: T3.6.10.24
database_cross_reference: HPO:HP:0410156

Increased level of N-acetylneuraminic acid in fibroblasts
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An increase in the level of N-acetylneuraminic acid in cultured fibroblasts.
PMOID: PMO:00003751
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Increased level of NANA in fibroblasts
Synonym: Increased level of Neu5Ac in fibroblasts
Synonym: Increased level of sialic acid in fibroblasts
Tree Number: T3.6.10.23
database_cross_reference: HPO:HP:0410157

Abnormality of the chest musculature
type: Class
subclass of: Abnormality of the musculature
definition: Any abnormality of the chest muscles.
PMOID: PMO:00009711
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.7
database_cross_reference: HPO:HP:0410167

Abnormality of the back musculature
type: Class
subclass of: Abnormality of the musculature
definition: Any abnormality of the back muscles.
PMOID: PMO:00009710
Subclass_of: Abnormality of the musculature
Tree Number: T3.17.6
database_cross_reference: HPO:HP:0410168

Abnormality of the shoulder musculature
type: Class
subclass of: Abnormality of the musculature
definition: Any abnormality of the shoulder muscles.
PMOID: PMO:00009748
Subclass_of: Abnormality of the musculature
Synonym: Muscle issues in the shoulder
Tree Number: T3.17.12
database_cross_reference: HPO:HP:0410169

Blood xenobiotic
type: Class
subclass of: Presence of xenobiotic
definition: The presence of a xenobiotic in blood.
PMOID: PMO:00004270
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.1
database_cross_reference: HPO:HP:0410172

Ketonemia
type: Class
subclass of: Ketosis
definition: An increase in the level of ketone bodies in the blood.
PMOID: PMO:00004267
Subclass_of: Ketosis
Synonym: Acetonemia
Synonym: Acetonemias
Synonym: Increased level of ketone bodies in blood
Synonym: Increased serum ketones
Synonym: KETONEMIA
Synonym: Ketoacidemia
Synonym: Ketoacidemias
Synonym: Ketonaemia
Synonym: Ketonemia (disorder)
Synonym: Ketonemia (disorder) [Ambiguous]
Tree Number: T3.6.31.2
database_cross_reference: CCPSS:0047892
database_cross_reference: CHV:0000023533
database_cross_reference: HPO:HP:0001946
database_cross_reference: HPO:HP:0410175
database_cross_reference: MDR:10057592
database_cross_reference: MDR:10057599
database_cross_reference: MSH:D007662
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU012717
database_cross_reference: OMIM:MTHU020021
database_cross_reference: SNMI:D6-23406
database_cross_reference: SNOMEDCT_US:213281004
database_cross_reference: SNOMEDCT_US:45317003
database_cross_reference: SNOMEDCT_VET:313041000009106

Abnormal glucose-6-phosphate dehydrogenase level
type: Class
subclass of: Abnormality of carbohydrate metabolism/homeostasis
definition: An anomaly in the level of glucose-6-phosphate dehydrogenase.
PMOID: PMO:00003674
Subclass_of: Abnormality of carbohydrate metabolism/homeostasis
Synonym: Abnormal G6PD level
Tree Number: T3.6.10.3
database_cross_reference: HPO:HP:0410176

Abnormal uridine diphosphate glucose-4-epimerase activity
type: Class
subclass of: Abnormal enzyme/coenzyme activity
definition: An abnormality in uridine diphosphate glucose-4-epimerase activity, an enzyme that catalyzes the reaction: UDP-glucose = UDP-galactose.
PMOID: PMO:00003555
Subclass_of: Abnormal enzyme/coenzyme activity
Synonym: Abnormal UDP-glucose 4-epimerase activity activity
Tree Number: T3.6.3.7
database_cross_reference: HPO:HP:0410192

Abnormal circulating nicotinurate level
type: Class
subclass of: Abnormality of nitrogen compound homeostasis
definition: Any deviation from the normal concentration of nicotinurate in the blood.
PMOID: PMO:00004144
Subclass_of: Abnormality of nitrogen compound homeostasis
Synonym: Abnormal circulating N-nicotinoylglycine level
Tree Number: T3.6.18.3
database_cross_reference: HPO:HP:0410205

Body odor
type: Class
subclass of: Constitutional symptom
definition: A perceived unpleasant smell given off by the body.
PMOID: PMO:00014049
Subclass_of: Constitutional symptom
Synonym: BO
Synonym: Body odour
Synonym: Bromhidrosis
Synonym: Bromidrosis
Synonym: Osmidrosis
Tree Number: T3.23.2
database_cross_reference: HPO:HP:0500001

Anal pain
type: Class
subclass of: Pain
definition: Pain in and around the anus or rectum (perianal region).
PMOID: PMO:00014079
Subclass_of: Pain
Synonym: ANAL PAIN
Synonym: Anal Pain
Synonym: Anal pain (disorder)
Synonym: Anal pain (finding)
Synonym: Anus pain
Synonym: Pain anal
Synonym: Pain;anal
Synonym: Rectal pain
Synonym: anal pain
Synonym: anal pain (symptom)
Tree Number: T3.23.10.3
database_cross_reference: CHV:0000024076
database_cross_reference: DXP:U000165
database_cross_reference: HPO:HP:0500005
database_cross_reference: ICPC2P:D04001
database_cross_reference: MDR:10002167
database_cross_reference: MDR:10002854
database_cross_reference: MDR:10033377
database_cross_reference: MEDCIN:110377
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C78172
database_cross_reference: NCI_CTCAE:E10486
database_cross_reference: RCD:J5747
database_cross_reference: SNMI:D5-44070
database_cross_reference: SNOMEDCT_US:68653001

Abnormality of gonadotropin-releasing hormone level
type: Class
subclass of: Abnormality of circulating hormone level
definition: A deviation from the normal circulating concentration of the normal gonadotropin-releasing hormone level secreted from the pituitary gland.
PMOID: PMO:00006189
Subclass_of: Abnormality of circulating hormone level
Synonym: Abnormality of GnRH level
Tree Number: T3.12.3.17
database_cross_reference: HPO:HP:0500012

Abnormal cardiac test
type: Class
subclass of: Abnormality of the cardiovascular system
definition: Abnormal test result of cardiovascular physiology.
PMOID: PMO:00004442
Subclass_of: Abnormality of the cardiovascular system
Tree Number: T3.9.1
database_cross_reference: HPO:HP:0500015

Abnormal cardiac MRI
type: Class
subclass of: Abnormal cardiac test
definition: Abnormal results of a MRI for the heart.
PMOID: PMO:00004448
Subclass_of: Abnormal cardiac test
Synonym: Abnormal cardiac magnetic resonance imaging
Synonym: Abnormal heart MRI
Tree Number: T3.9.1.4
database_cross_reference: HPO:HP:0500016

Abnormal cardiac catheterization
type: Class
subclass of: Abnormal cardiac test
definition: Abnormal results from the diagnostic tests resulting from cardiac catheterization.
PMOID: PMO:00004446
Subclass_of: Abnormal cardiac test
Synonym: Abnormal cardiac cath
Tree Number: T3.9.1.2
database_cross_reference: HPO:HP:0500017

Abnormal cardiac exercise stress test
type: Class
subclass of: Abnormal cardiac test
definition: Abnormal results of exercise on heart function.
PMOID: PMO:00004447
Subclass_of: Abnormal cardiac test
Synonym: Abnormal cardiac exercise test
Synonym: Abnormal treadmill test
Tree Number: T3.9.1.3
database_cross_reference: HPO:HP:0500018

Abnormal resting energy expenditure from metabolic cart test
type: Class
subclass of: Abnormal cardiac test
definition: Resting energy expenditure (REE) can be measured with indirect calorimetry using a metabolic cart, which is used to measure the oxygen consumption (VO2) and carbon dioxide production (VCO2).
PMOID: PMO:00004449
Subclass_of: Abnormal cardiac test
Synonym: Abnormal metabolic cart test
Tree Number: T3.9.1.5
database_cross_reference: HPO:HP:0500019

Abnormal cardiac biomarker test
type: Class
subclass of: Abnormal cardiac test
definition: Abnormal blood test results measuring creatine kinase (CK), CK-MB, troponin (TROPI), myoglobin, and/or cardiac enzymes.
PMOID: PMO:00004443
Subclass_of: Abnormal cardiac test
Tree Number: T3.9.1.1
database_cross_reference: HPO:HP:0500020

Stool xenobiotic
type: Class
subclass of: Presence of xenobiotic
definition: Presence of xenobiotic in stool.
PMOID: PMO:00004279
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.4
database_cross_reference: HPO:HP:0500097

Hair xenobiotic
type: Class
subclass of: Presence of xenobiotic
definition: Presence of xenobiotic in hair.
PMOID: PMO:00004277
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.3
database_cross_reference: HPO:HP:0500099

Gastric fluid xenobiotic
type: Class
subclass of: Presence of xenobiotic
definition: Presence of a xenobiotic in gastric fluid.
PMOID: PMO:00004275
Subclass_of: Presence of xenobiotic
Tree Number: T3.6.33.2
database_cross_reference: HPO:HP:0500101

Abnormality of platysma
type: Class
subclass of: Abnormality of the musculature of the neck
definition: An abnormality of the platysma muscle.
PMOID: PMO:00009727
Subclass_of: Abnormality of the musculature of the neck
Synonym: Abnormality of the platysma muscle
Tree Number: T3.17.9.2
database_cross_reference: HPO:HP:3000013

Abnormality of geniohyoid muscle
type: Class
subclass of: Abnormality of the musculature of the neck
definition: An abnormality of a geniohyoid muscle.
PMOID: PMO:00009726
Subclass_of: Abnormality of the musculature of the neck
Tree Number: T3.17.9.1
database_cross_reference: HPO:HP:3000046

Anatomical Structure
type: Class
subclass of: Thing
PMOID: PMO:00000001
Subclass_of: owl:Thing
Synonym: Anatomic structures
Synonym: Anatomical structure
Synonym: Anatomical structure (body structure)
Synonym: Anatomy
Synonym: Biological structure
Synonym: anatomic structure
Synonym: anatomical structure
Synonym: anatomical structures
Synonym: anatomy
Synonym: biological structure
Tree Number: T1
database_cross_reference: AOD:0000001708
database_cross_reference: AOD:0000017024
database_cross_reference: CHV:0000042886
database_cross_reference: CHV:0000044715
database_cross_reference: CSP:4000-0131
database_cross_reference: FMA:305751
database_cross_reference: FMA:67135
database_cross_reference: MEDLINEPLUS:138
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:T-D0005
database_cross_reference: SNOMEDCT_US:91723000
database_cross_reference: UWDA:67135

Embryonic Structures
type: Class
subclass of: Anatomical Structure
PMOID: PMO:00000002
Subclass_of: Anatomical Structure
Synonym: EMBRYONIC STRUCTURES
Synonym: Embryologic Structure
Synonym: Embryological structure
Synonym: Embryonic Structure
Synonym: Embryonic structure
Synonym: Embryonic structure (body structure)
Synonym: Embryonic structure, NOS
Synonym: F6-F7 EMBRYONIC STRUCTURES
Synonym: Structure, Embryonic
Synonym: Structures, Embryonic
Tree Number: T1.1
database_cross_reference: FMA:69067
database_cross_reference: MSH:D004628
database_cross_reference: NCI:C13229
database_cross_reference: RCD:Xa1Ia
database_cross_reference: SNMI:T-F6000
database_cross_reference: SNOMEDCT_US:667009

Gubernaculum
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000003
Subclass_of: Embryonic Structures
Synonym: Gubernacula
Tree Number: T1.1.1
database_cross_reference: MSH:D000071477

Blastomeres
type: Class
subclass of: Embryonic Structures
subclass of: Embryonic Stem Cells
PMOID: PMO:00000004
Subclass_of: Embryonic Stem Cells
Subclass_of: Embryonic Structures
Synonym: Blastomere
Synonym: Embryo stage 2
Synonym: Structure of blastomere
Synonym: Structure of blastomere (body structure)
Synonym: Structure of embryo stage 2
Synonym: Structure of embryo stage 2 (body structure)
Synonym: blastomere
Synonym: blastomeres
Tree Number: T1.1.2
Tree Number: T2.34.7.1.4
database_cross_reference: CHV:0000001962
database_cross_reference: CHV:0000057128
database_cross_reference: FMA:72551
database_cross_reference: MSH:D001757
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12518
database_cross_reference: SNOMEDCT_US:14938003
database_cross_reference: SNOMEDCT_US:296383004
database_cross_reference: SNOMEDCT_US:367618007
database_cross_reference: UWDA:72551

Branchial Region
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000005
Subclass_of: Embryonic Structures
Synonym: Branchial Regions
Synonym: Region, Branchial
Synonym: Regions, Branchial
Tree Number: T1.1.3
database_cross_reference: MSH:D001934

Cleavage Stage, Ovum
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000006
Subclass_of: Embryonic Structures
Synonym: Cleavage Stages, Ovum
Synonym: Embryo stage 1
Synonym: Embryo stage 1 structure
Synonym: Embryo stage 1 structure (body structure)
Synonym: Ovum Cleavage Stage
Synonym: Ovum Cleavage Stages
Synonym: Ovum Segmentation Stage
Synonym: Ovum Segmentation Stages
Synonym: Segmentation Stage, Ovum
Synonym: Segmentation Stages, Ovum
Tree Number: T1.1.4
database_cross_reference: CSP:1016-6956
database_cross_reference: MSH:D002970
database_cross_reference: SNMI:T-F5101
database_cross_reference: SNOMEDCT_US:9156001

Cloaca
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000007
Subclass_of: Embryonic Structures
Synonym: CLOACA
Synonym: Cloaca Chamber
Synonym: Cloaca NOS
Synonym: Cloaca structure
Synonym: Cloaca structure (body structure)
Synonym: Cloacas
Synonym: cloaca
Tree Number: T1.1.5
database_cross_reference: CHV:0000003048
database_cross_reference: ICD10CM:Q43.7
database_cross_reference: MSH:D002988
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34127
database_cross_reference: NCI_CDISC:C34127
database_cross_reference: SNM:T-89430
database_cross_reference: SNMI:T-F6630
database_cross_reference: SNOMEDCT_US:64582000

Embryo, Mammalian
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000008
Subclass_of: Embryonic Structures
Synonym: Embryos, Mammalian
Synonym: Mammalian Embryo
Synonym: Mammalian Embryos
Tree Number: T1.1.6
database_cross_reference: MSH:D004622

Blastocyst
type: Class
subclass of: Embryo, Mammalian
PMOID: PMO:00000009
Subclass_of: Embryo, Mammalian
Synonym: Blastocyst structure
Synonym: Blastocyst structure (body structure)
Synonym: Blastocysts
Synonym: Blastosphere
Synonym: Blastula
Synonym: Embryo, Preimplantation
Synonym: Embryos, Preimplantation
Synonym: Preimplantation Embryo
Synonym: Preimplantation Embryos
Synonym: blastocyst
Tree Number: T1.1.6.1
database_cross_reference: AOD:0000002019
database_cross_reference: AOD:0000021711
database_cross_reference: AOD:0000021712
database_cross_reference: CHV:0000001960
database_cross_reference: CHV:0000057130
database_cross_reference: CSP:1016-6956
database_cross_reference: FMA:83041
database_cross_reference: LCH:U000602
database_cross_reference: LCH_NW:sh85014801
database_cross_reference: MSH:D001755
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13739
database_cross_reference: SNOMEDCT_US:308765000

Trophoblasts
type: Class
subclass of: Blastocyst
subclass of: Placenta
subclass of: Endocrine Cells
PMOID: PMO:00000010
Subclass_of: Blastocyst
Subclass_of: Endocrine Cells
Subclass_of: Placenta
Synonym: Trophoblast
Synonym: Trophoblast structure
Synonym: Trophoblast structure (body structure)
Synonym: Trophoblast, NOS
Synonym: trophoblast
Synonym: trophoblasts
Tree Number: T1.1.17.3
Tree Number: T1.1.6.1.1
Tree Number: T2.11.6
database_cross_reference: CHV:0000012594
database_cross_reference: CSP:2404-5986
database_cross_reference: FMA:83029
database_cross_reference: LCH:U004791
database_cross_reference: LCH_NW:sh85138048
database_cross_reference: LNC:LP65556-0
database_cross_reference: LNC:MTHU026848
database_cross_reference: MSH:D014327
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C93292
database_cross_reference: NCI_NCI-GLOSS:CDR0000446120
database_cross_reference: SNM:T-88110
database_cross_reference: SNMI:T-F1110
database_cross_reference: SNOMEDCT_US:25149004

Blastocyst Inner Cell Mass
type: Class
subclass of: Blastocyst
PMOID: PMO:00000011
Subclass_of: Blastocyst
Synonym: Inner Cell Mass of Blastocyst
Synonym: Inner Cell Mass, Blastocyst
Tree Number: T1.1.6.1.2
database_cross_reference: MSH:D053624

Extraembryonic Membranes
type: Class
subclass of: Embryo, Mammalian
subclass of: Membranes
PMOID: PMO:00000012
Subclass_of: Embryo, Mammalian
Subclass_of: Membranes
Synonym: Extra Embryonic Membranes
Synonym: Extra-Embryonic Membrane
Synonym: Extra-Embryonic Membranes
Synonym: Extra-embryonic membrane
Synonym: Extraembryonic Membrane
Synonym: Extraembryonic membranes
Synonym: Extraembryonic membranes (body structure)
Synonym: Extraembryonic membranes structure
Synonym: Extraembryonic membranes structure (body structure)
Synonym: Foetal membranes
Tree Number: T1.1.6.2
Tree Number: T1.3.8.2
database_cross_reference: FMA:305915
database_cross_reference: MSH:D005321
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:326483006
database_cross_reference: SNOMEDCT_US:54134001

Allantois
type: Class
subclass of: Extraembryonic Membranes
PMOID: PMO:00000013
Subclass_of: Extraembryonic Membranes
Synonym: Allantoic Membrane
Synonym: Membrane, Allantoic
Synonym: Structure of allantois
Synonym: Structure of allantois (body structure)
Tree Number: T1.1.6.2.1
Tree Number: T1.3.8.2.1
database_cross_reference: MSH:D000482
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34101
database_cross_reference: SNM:T-88840
database_cross_reference: SNMI:T-F1840
database_cross_reference: SNOMEDCT_US:83575002

Amnion
type: Class
subclass of: Extraembryonic Membranes
PMOID: PMO:00000014
Subclass_of: Extraembryonic Membranes
Synonym: Amnions
Synonym: Amniotic
Synonym: Amniotic Membrane
Synonym: Amniotic Membranes
Synonym: Amniotic sac
Synonym: Membrane, Amniotic
Synonym: Membranes, Amniotic
Synonym: Structure of amnion
Synonym: Structure of amnion (body structure)
Synonym: amnion
Tree Number: T1.1.6.2.2
Tree Number: T1.3.8.2.2
database_cross_reference: AOD:0000017038
database_cross_reference: CHV:0000001037
database_cross_reference: CSP:2404-5654
database_cross_reference: FMA:80223
database_cross_reference: LCH:U000208
database_cross_reference: LCH_NW:sh85004562
database_cross_reference: MSH:D000650
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12365
database_cross_reference: SNM:T-88300
database_cross_reference: SNMI:T-F1300
database_cross_reference: SNOMEDCT_US:70847004

Chorion
type: Class
subclass of: Extraembryonic Membranes
PMOID: PMO:00000015
Subclass_of: Extraembryonic Membranes
Synonym: Chorion, NOS
Synonym: Chorionic
Synonym: Chorionic structure
Synonym: Chorionic structure (body structure)
Synonym: Chorions
Synonym: chorion
Synonym: chorions
Tree Number: T1.1.6.2.3
Tree Number: T1.3.8.2.3
database_cross_reference: CHV:0000002911
database_cross_reference: CSP:2404-5873
database_cross_reference: FMA:80224
database_cross_reference: LCH:U001000
database_cross_reference: LCH_NW:sh85024748
database_cross_reference: MSH:D002823
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34122
database_cross_reference: SNM:T-88210
database_cross_reference: SNMI:T-F1210
database_cross_reference: SNOMEDCT_US:74439004

Chorionic Villi
type: Class
subclass of: Placenta
PMOID: PMO:00000016
Subclass_of: Placenta
Synonym: Chorionic Villus
Synonym: Chorionic villi
Synonym: Chorionic villi structure
Synonym: Chorionic villi structure (body structure)
Synonym: Chorionic villi, NOS
Synonym: Chorionic villus
Synonym: Placental Villi
Synonym: Placental Villus
Synonym: Villi, Chorionic
Synonym: Villi, Placental
Tree Number: T1.1.17.1
database_cross_reference: CHV:0000002912
database_cross_reference: LCH:U001001
database_cross_reference: LCH_NW:sh85024752
database_cross_reference: LNC:LP208150-5
database_cross_reference: MSH:D002824
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34125
database_cross_reference: SNM:T-88220
database_cross_reference: SNMI:T-F1220
database_cross_reference: SNOMEDCT_US:2049008

Yolk Sac
type: Class
subclass of: Extraembryonic Membranes
subclass of: Embryo, Nonmammalian
PMOID: PMO:00000017
Subclass_of: Embryo, Nonmammalian
Subclass_of: Extraembryonic Membranes
Synonym: Embryo Vitelline Sac
Synonym: Embryo Vitelline Sacs
Synonym: SAC, YOLK
Synonym: Sac, Yolk
Synonym: Sacs, Yolk
Synonym: Umbilical vesicle
Synonym: Vitelline Sac of Embryo
Synonym: Yolk Sacs
Synonym: Yolk sac
Synonym: Yolk sac structure
Tree Number: T1.1.6.2.4
Tree Number: T1.1.7.3
Tree Number: T1.3.8.2.4
database_cross_reference: CHV:0000013264
database_cross_reference: CSP:5004-0085
database_cross_reference: FMA:87180
database_cross_reference: LCH:U005078
database_cross_reference: LCH_NW:sh85149208
database_cross_reference: LNC:LP7737-2
database_cross_reference: LNC:MTHU002919
database_cross_reference: MSH:D015017
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C14128
database_cross_reference: NCI_CDISC:C14128
database_cross_reference: SNM:T-88400
database_cross_reference: SNMI:T-F1400
database_cross_reference: SNOMEDCT_US:26190007

Embryo, Nonmammalian
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000018
Subclass_of: Embryonic Structures
Synonym: Embryo, Non Mammalian
Synonym: Embryo, Non-Mammalian
Synonym: Embryos, Non-Mammalian
Synonym: Embryos, Nonmammalian
Synonym: Non-Mammalian Embryo
Synonym: Non-Mammalian Embryos
Synonym: Nonmammalian Embryo
Synonym: Nonmammalian Embryos
Tree Number: T1.1.7
database_cross_reference: MSH:D004625

Blastoderm
type: Class
subclass of: Embryo, Nonmammalian
PMOID: PMO:00000019
Subclass_of: Embryo, Nonmammalian
Synonym: Blastoderms
Tree Number: T1.1.7.1
database_cross_reference: LCH:U000603
database_cross_reference: LCH_NW:sh85014802
database_cross_reference: MSH:D001756

Chick Embryo
type: Class
subclass of: Embryo, Nonmammalian
PMOID: PMO:00000020
Subclass_of: Embryo, Nonmammalian
Synonym: Chick Embryos
Synonym: Chick embryo
Synonym: Embryo, Chick
Synonym: Embryos, Chick
Synonym: chick embryo
Synonym: chick embryos
Tree Number: T1.1.7.2
database_cross_reference: AOD:0000016551
database_cross_reference: CHV:0000002760
database_cross_reference: CSP:0182-1050
database_cross_reference: LCH:U000944
database_cross_reference: MSH:D002642

Blastula
type: Class
subclass of: Embryo, Nonmammalian
PMOID: PMO:00000021
Subclass_of: Embryo, Nonmammalian
Synonym: Blastulae
Synonym: Non - mammalian blastula
Tree Number: T1.1.7.4
database_cross_reference: LCH_NW:sh94004613
database_cross_reference: MSH:D036703
database_cross_reference: MTH:NOCODE

Chorioallantoic Membrane
type: Class
subclass of: Extraembryonic Membranes
subclass of: Embryo, Nonmammalian
PMOID: PMO:00000022
Subclass_of: Embryo, Nonmammalian
Subclass_of: Extraembryonic Membranes
Synonym: CAM
Synonym: Chorioallantoic Membranes
Synonym: Membrane, Chorioallantoic
Synonym: Membranes, Chorioallantoic
Synonym: chorioallantoic membrane
Tree Number: T1.1.7.5
Tree Number: T1.3.8.2.5
database_cross_reference: CHV:0000018317
database_cross_reference: CSP:2404-5873
database_cross_reference: MSH:D049033
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C28216
database_cross_reference: NCI_NCI-GLOSS:CDR0000044193

Blastodisc
type: Class
subclass of: Embryo, Nonmammalian
PMOID: PMO:00000023
Subclass_of: Embryo, Nonmammalian
Synonym: Area, Germinal
Synonym: Areas, Germinal
Synonym: Blastodiscs
Synonym: Disc, Germinal
Synonym: Discs, Germinal
Synonym: Germinal Area
Synonym: Germinal Areas
Synonym: Germinal Disc
Synonym: Germinal Discs
Synonym: Structure of blastodisc
Tree Number: T1.1.7.6
database_cross_reference: MSH:D054239
database_cross_reference: SNOMEDCT_VET:41961000009100

Fetus
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000024
Subclass_of: Embryonic Structures
Synonym: FETUS
Synonym: Fetal
Synonym: Fetus (person)
Synonym: Fetuses
Synonym: ^Fetus
Synonym: fetus
Synonym: fetuses
Tree Number: T1.1.8
database_cross_reference: AOD:0000014678
database_cross_reference: CHV:0000005009
database_cross_reference: FMA:63919
database_cross_reference: LCH:U001775
database_cross_reference: LCH_NW:sh85047965
database_cross_reference: LNC:LP104995-8
database_cross_reference: LNC:LP207308-0
database_cross_reference: LNC:LP36106-0
database_cross_reference: LNC:LP6982-5
database_cross_reference: LNC:MTHU002972
database_cross_reference: MSH:D005333
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13235
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13235
database_cross_reference: NCI_NCI-GLOSS:CDR0000046400
database_cross_reference: NCI_NICHD:C13235
database_cross_reference: PSY:19650
database_cross_reference: RCD:7N612
database_cross_reference: SNM:T-89000
database_cross_reference: SNOMEDCT_US:393497002
database_cross_reference: SNOMEDCT_US:394447009

Amniotic Fluid
type: Class
subclass of: Fetus
PMOID: PMO:00000025
Subclass_of: Fetus
Synonym: AF - Amniotic fluid
Synonym: AMNIOTIC FLUID
Synonym: Amniotic Fluids
Synonym: Amniotic fluid
Synonym: Amniotic fluid (substance)
Synonym: Aqua Amnii
Synonym: FLUID, AMNIOTIC
Synonym: Fluid, Amniotic
Synonym: Fluids, Amniotic
Synonym: Liquor
Tree Number: T1.1.8.1
database_cross_reference: AOD:0000017039
database_cross_reference: CHV:0000001040
database_cross_reference: CSP:2404-0111
database_cross_reference: FMA:305905
database_cross_reference: LNC:LP208080-4
database_cross_reference: LNC:LP20977-2
database_cross_reference: LNC:MTHU001056
database_cross_reference: MSH:D000653
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13188
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13188
database_cross_reference: NCI_CDISC:SDTM-SPECTYPE
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: OMIM:MTHU001616
database_cross_reference: PSY:02130
database_cross_reference: RCD:X79bU
database_cross_reference: SNM:T-8Y300
database_cross_reference: SNMI:T-F1320
database_cross_reference: SNOMEDCT_US:256863002
database_cross_reference: SNOMEDCT_US:77012006

Fetal Blood
type: Class
subclass of: Fetus
PMOID: PMO:00000026
Subclass_of: Fetus
Synonym: Blood, Fetal
Synonym: Bloods, Fetal
Synonym: Fetal Bloods
Synonym: Fetal blood
Synonym: fetal blood
Tree Number: T1.1.8.2
database_cross_reference: CHV:0000004987
database_cross_reference: CSP:5000-0024
database_cross_reference: LCH:U001770
database_cross_reference: LCH_NW:sh85047943
database_cross_reference: LNC:LP62758-5
database_cross_reference: LNC:MTHU025654
database_cross_reference: MSH:D005312
database_cross_reference: MTH:NOCODE

Fetal Heart
type: Class
subclass of: Fetus
PMOID: PMO:00000027
Subclass_of: Fetus
Synonym: Fetal Hearts
Synonym: Fetal heart
Synonym: Heart, Fetal
Synonym: Hearts, Fetal
Synonym: fetal heart
Synonym: heart fetal
Tree Number: T1.1.8.3
database_cross_reference: CHV:0000004993
database_cross_reference: FMA:63931
database_cross_reference: LCH_NW:sh85047946
database_cross_reference: MSH:D005318
database_cross_reference: NCI:C34167

Ductus Arteriosus
type: Class
subclass of: Fetal Heart
PMOID: PMO:00000028
Subclass_of: Fetal Heart
Synonym: Arterial canal
Synonym: Arterial duct
Synonym: Arteriosus, Ductus
Synonym: Botallo's duct
Synonym: Ductus arteriosus
Synonym: Pulmoaortic canal
Synonym: Structure of ductus arteriosus
Synonym: Structure of ductus arteriosus (body structure)
Synonym: arterial canal
Synonym: arterial duct
Tree Number: T1.1.8.3.1
database_cross_reference: CHV:0000004171
database_cross_reference: CSP:0581-0789
database_cross_reference: CSP:2401-7877
database_cross_reference: FMA:79871
database_cross_reference: LCH:U001474
database_cross_reference: LCH_NW:sh85039885
database_cross_reference: LNC:LP7185-4
database_cross_reference: LNC:MTHU001509
database_cross_reference: MSH:D004373
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C52854
database_cross_reference: OMIM:MTHU002344
database_cross_reference: RCD:X781R
database_cross_reference: SNM:T-89645
database_cross_reference: SNMI:T-F6845
database_cross_reference: SNOMEDCT_US:4432005
database_cross_reference: UWDA:13421

Truncus Arteriosus
type: Class
subclass of: Fetal Heart
PMOID: PMO:00000029
Subclass_of: Fetal Heart
Synonym: Arteriosus, Truncus
Synonym: Common arterial trunk
Synonym: Structure of truncus arteriosus of fetus
Synonym: Structure of truncus arteriosus of fetus (body structure)
Synonym: Structure of truncus arteriosus of foetus
Synonym: TA - Truncus arteriosus
Synonym: TRUNCUS ARTERIOSUS
Synonym: Truncus arteriosus
Synonym: Truncus arteriosus of fetus
Synonym: Truncus arteriosus of foetus
Tree Number: T1.1.8.3.2
database_cross_reference: CHV:0000012603
database_cross_reference: FMA:70301
database_cross_reference: HPO:HP:0001660
database_cross_reference: LCH:U004795
database_cross_reference: LCH_NW:sh85138253
database_cross_reference: MSH:D014338
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:600584
database_cross_reference: OMIM:MTHU001442
database_cross_reference: RCD:XaBcz
database_cross_reference: SNM:T-89630
database_cross_reference: SNMI:T-F6830
database_cross_reference: SNOMEDCT_US:58140002

Endocardial Cushions
type: Class
subclass of: Fetal Heart
PMOID: PMO:00000030
Subclass_of: Fetal Heart
Synonym: Atrioventricular Canal Cushion
Synonym: Atrioventricular Canal Cushions
Synonym: Atrioventricular canal cushion
Synonym: Endocardial Cushion
Synonym: Endocardial cushion
Synonym: Structure of atrioventricular canal cushion
Synonym: Structure of atrioventricular canal cushion (body structure)
Synonym: endocardial cushion
Tree Number: T1.1.8.3.3
database_cross_reference: CHV:0000022598
database_cross_reference: FMA:70302
database_cross_reference: MSH:D054089
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-89650
database_cross_reference: SNMI:T-F6850
database_cross_reference: SNOMEDCT_US:68696006

Meconium
type: Class
subclass of: Fetus
PMOID: PMO:00000031
Subclass_of: Fetus
Synonym: Meconium (substance)
Synonym: Meconium stool
Synonym: Meconium stool (substance)
Synonym: Meconiums
Synonym: meconium
Synonym: meconium stool
Tree Number: T1.1.8.4
database_cross_reference: AOD:0000016844
database_cross_reference: CHV:0000007830
database_cross_reference: CSP:1248-7608
database_cross_reference: LCH:U002851
database_cross_reference: LCH_NW:sh85082793
database_cross_reference: LNC:LP19409-9
database_cross_reference: LNC:LP7413-0
database_cross_reference: LNC:MTHU001001
database_cross_reference: LNC:MTHU051573
database_cross_reference: MSH:D008470
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X79bf
database_cross_reference: SNM:T-8Y420
database_cross_reference: SNMI:T-F6B25
database_cross_reference: SNOMEDCT_US:256869003
database_cross_reference: SNOMEDCT_US:28112009

Umbilical Cord
type: Class
subclass of: Fetus
PMOID: PMO:00000032
Subclass_of: Fetus
Synonym: Cord, Umbilical
Synonym: Cords, Umbilical
Synonym: F18 UMBILICAL CORD
Synonym: UMBILICAL CORD
Synonym: Umbilical Cords
Synonym: Umbilical cord
Synonym: Umbilical cord structure
Synonym: Umbilical cord structure (body structure)
Synonym: Umbilical cord, NOS
Synonym: umbilical cord
Tree Number: T1.1.8.5
database_cross_reference: AOD:0000017036
database_cross_reference: CHV:0000012711
database_cross_reference: CSP:2403-6526
database_cross_reference: FMA:85541
database_cross_reference: LCH:U004843
database_cross_reference: LCH_NW:sh85139520
database_cross_reference: LNC:LP208557-1
database_cross_reference: LNC:LP7676-2
database_cross_reference: LNC:MTHU003060
database_cross_reference: MSH:D014470
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34320
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C34320
database_cross_reference: NCI_NICHD:C34320
database_cross_reference: RCD:Xa1UZ
database_cross_reference: SNM:T-88800
database_cross_reference: SNMI:T-F1800
database_cross_reference: SNOMEDCT_US:29870000

Umbilical Arteries
type: Class
subclass of: Umbilical Cord
PMOID: PMO:00000033
Subclass_of: Umbilical Cord
Synonym: Arteria umbilicalis
Synonym: Arteries, Umbilical
Synonym: Artery, Umbilical
Synonym: Structure of umbilical artery
Synonym: Structure of umbilical artery (body structure)
Synonym: Umbilical Artery
Synonym: Umbilical artery
Synonym: umbilical arteries
Synonym: umbilical artery
Tree Number: T1.1.8.5.1
database_cross_reference: CHV:0000012710
database_cross_reference: FMA:18820
database_cross_reference: LNC:LP208556-3
database_cross_reference: LNC:LP7671-3
database_cross_reference: LNC:MTHU024461
database_cross_reference: MSH:D014469
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33827
database_cross_reference: RCD:X90K9
database_cross_reference: SNM:T-88810
database_cross_reference: SNMI:T-F1810
database_cross_reference: SNOMEDCT_US:50536004
database_cross_reference: UWDA:18820

Umbilical Veins
type: Class
subclass of: Umbilical Cord
PMOID: PMO:00000034
Subclass_of: Umbilical Cord
Synonym: Structure of umbilical vein
Synonym: Structure of umbilical vein (body structure)
Synonym: Umbilical Vein
Synonym: Umbilical vein
Synonym: Umbilical vein (body structure)
Synonym: Umbilical vein, fetal
Synonym: Vein, Umbilical
Synonym: Veins, Umbilical
Synonym: Vena umbilicalis
Synonym: umbilical vein
Tree Number: T1.1.8.5.2
database_cross_reference: CHV:0000012713
database_cross_reference: CHV:0000022583
database_cross_reference: FMA:70317
database_cross_reference: LNC:LP7677-0
database_cross_reference: LNC:MTHU002917
database_cross_reference: MSH:D014471
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33830
database_cross_reference: RCD:X74hG
database_cross_reference: SNM:T-88820
database_cross_reference: SNM:T-89695
database_cross_reference: SNMI:T-F1820
database_cross_reference: SNOMEDCT_US:367567000

Vernix Caseosa
type: Class
subclass of: Fetus
PMOID: PMO:00000035
Subclass_of: Fetus
Synonym: Caseosa, Vernix
Synonym: Caseosas, Vernix
Synonym: Vernix
Synonym: Vernix Caseosa (substance)
Synonym: Vernix Caseosas
Synonym: Vernix caseosa
Synonym: Vernix caseosa (body structure)
Synonym: Vernix caseosa (substance)
Synonym: vernix caseosa
Tree Number: T1.1.8.6
database_cross_reference: CHV:0000012962
database_cross_reference: MSH:D014708
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34328
database_cross_reference: SNOMEDCT_US:416814000
database_cross_reference: SNOMEDCT_US:58480003

Aborted Fetus
type: Class
subclass of: Fetus
PMOID: PMO:00000036
Subclass_of: Fetus
Synonym: Aborted Embryo
Synonym: Aborted Embryos
Synonym: Aborted Fetus (structure)
Synonym: Aborted Fetuses
Synonym: Abortus
Synonym: Embryo, Aborted
Synonym: Embryos, Aborted
Synonym: Fetus under 500gms
Synonym: Fetus, Aborted
Synonym: Fetuses, Aborted
Tree Number: T1.1.8.7
database_cross_reference: CHV:0000000544
database_cross_reference: CHV:0000000559
database_cross_reference: MSH:D037881
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C73436
database_cross_reference: SNM:M-28000
database_cross_reference: SNMI:T-F5202
database_cross_reference: SNOMEDCT_US:28677006

Gastrula
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000037
Subclass_of: Embryonic Structures
Synonym: Gastrulas
Synonym: gastrula
Synonym: invaginate planula
Tree Number: T1.1.9
database_cross_reference: AOD:0000002025
database_cross_reference: AOD:0000021726
database_cross_reference: CSP:1016-6956
database_cross_reference: FMA:293108
database_cross_reference: MSH:D005775
database_cross_reference: NCI:C34057

Germ Layers
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000038
Subclass_of: Embryonic Structures
Synonym: Germ Layer
Synonym: Germ layer
Synonym: Layer, Germ
Synonym: Layers, Germ
Synonym: germ layer
Tree Number: T1.1.10
database_cross_reference: CSP:1016-7268
database_cross_reference: FMA:293071
database_cross_reference: MSH:D005855
database_cross_reference: MTH:NOCODE

Ectoderm
type: Class
subclass of: Germ Layers
PMOID: PMO:00000039
Subclass_of: Germ Layers
Synonym: Ectoderm structure
Synonym: Ectoderm structure (body structure)
Synonym: Ectoderm, NOS
Synonym: Ectodermal
Synonym: Ectoderms
Synonym: ectoderm
Tree Number: T1.1.10.1
database_cross_reference: CHV:0000004263
database_cross_reference: CSP:1016-7297
database_cross_reference: FMA:69070
database_cross_reference: MSH:D004475
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12703
database_cross_reference: SNM:T-89100
database_cross_reference: SNMI:T-F6100
database_cross_reference: SNOMEDCT_US:63206006

Endoderm
type: Class
subclass of: Germ Layers
PMOID: PMO:00000040
Subclass_of: Germ Layers
Synonym: Endoderm structure
Synonym: Endoderm structure (body structure)
Synonym: Endoderm, NOS
Synonym: Endoderms
Synonym: endoderm
Tree Number: T1.1.10.2
database_cross_reference: CHV:0000004454
database_cross_reference: CSP:1016-7373
database_cross_reference: FMA:69071
database_cross_reference: MSH:D004707
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12706
database_cross_reference: SNM:T-89400
database_cross_reference: SNMI:T-F6600
database_cross_reference: SNOMEDCT_US:55259008

Mesoderm
type: Class
subclass of: Germ Layers
PMOID: PMO:00000041
Subclass_of: Germ Layers
Synonym: Mesoderm structure
Synonym: Mesoderm structure (body structure)
Synonym: Mesoderm, NOS
Synonym: mesoderm
Tree Number: T1.1.10.3
database_cross_reference: CHV:0000007989
database_cross_reference: CSP:1016-7414
database_cross_reference: FMA:69072
database_cross_reference: LCH:U002920
database_cross_reference: LCH_NW:sh85083937
database_cross_reference: MSH:D008648
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12750
database_cross_reference: SNM:T-89200
database_cross_reference: SNMI:T-F6300
database_cross_reference: SNOMEDCT_US:64927000

Somites
type: Class
subclass of: Mesoderm
PMOID: PMO:00000042
Subclass_of: Mesoderm
Synonym: Somite
Synonym: somite
Synonym: somites
Tree Number: T1.1.10.3.1
database_cross_reference: CHV:0000031779
database_cross_reference: FMA:85522
database_cross_reference: LCH_NW:sh85124799
database_cross_reference: MSH:D019170
database_cross_reference: NCI:C34302

Pericytes
type: Class
subclass of: Mesoderm
subclass of: Endothelium
subclass of: Cell
PMOID: PMO:00000043
Subclass_of: Cell
Subclass_of: Endothelium
Subclass_of: Mesoderm
Synonym: Adventitial Cell
Synonym: Adventitial cell
Synonym: Cell of Rouget
Synonym: Cells, Rouget
Synonym: Pericapillary Cell
Synonym: Pericyte
Synonym: Pericyte of Rouget
Synonym: Pericyte of Rouget (cell)
Synonym: Perivascular Cell
Synonym: Rouget Cell
Tree Number: T1.1.10.3.2
Tree Number: T1.3.5.2.4
Tree Number: T2.26
database_cross_reference: AOD:0000017511
database_cross_reference: CHV:0000041942
database_cross_reference: CSP:0432-6461
database_cross_reference: FMA:63174
database_cross_reference: FMA:84639
database_cross_reference: MSH:D020286
database_cross_reference: NCI:C12656
database_cross_reference: SNM:T-1X320
database_cross_reference: SNMI:T-1A520
database_cross_reference: SNOMEDCT_US:34773004
database_cross_reference: UWDA:63174

Mesonephros
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000044
Subclass_of: Embryonic Structures
Synonym: Body, Wolffian
Synonym: Mesonephric structure
Synonym: Mesonephric structure (body structure)
Synonym: Mesonephroi
Synonym: Wolffian Body
Synonym: Wolffian body
Tree Number: T1.1.11
database_cross_reference: FMA:72171
database_cross_reference: LCH_NW:sh85147231
database_cross_reference: MSH:D008650
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26467
database_cross_reference: SNM:T-89350
database_cross_reference: SNMI:T-F6450
database_cross_reference: SNOMEDCT_US:21241002

Morula
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000045
Subclass_of: Embryonic Structures
Synonym: Morula (Embryonic Structure)
Synonym: Morula (body structure)
Synonym: Morulas
Synonym: morula
Tree Number: T1.1.12
database_cross_reference: CHV:0000008259
database_cross_reference: FMA:292334
database_cross_reference: MSH:D009028
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34212
database_cross_reference: SNOMEDCT_US:361474003

Mullerian Ducts
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000046
Subclass_of: Embryonic Structures
Synonym: Ducts, Mullerian
Synonym: Mullerian Duct
Synonym: Mullerian duct
Synonym: Müllerian Duct
Synonym: Paramesonephric Duct
Synonym: Paramesonephric duct
Synonym: Structure of paramesonephric duct
Synonym: Structure of paramesonephric duct (body structure)
Synonym: mullerian duct
Synonym: mullerian ducts
Tree Number: T1.1.13
database_cross_reference: CHV:0000008320
database_cross_reference: MSH:D009095
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13260
database_cross_reference: SNM:T-89390
database_cross_reference: SNMI:T-F6490
database_cross_reference: SNOMEDCT_US:26896004

Neural Crest
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000047
Subclass_of: Embryonic Structures
Synonym: Crest, Neural
Synonym: Crests, Neural
Synonym: Neural Crests
Synonym: Neural crest
Synonym: Neural crest (body structure)
Synonym: crest neural
Synonym: neural crest
Tree Number: T1.1.14
database_cross_reference: AOD:0000017031
database_cross_reference: CHV:0000008614
database_cross_reference: CSP:1016-7322
database_cross_reference: FMA:86666
database_cross_reference: LCH:U003175
database_cross_reference: LCH_NW:sh85091092
database_cross_reference: MSH:D009432
database_cross_reference: NCI:C34222
database_cross_reference: NEU:1366
database_cross_reference: SNOMEDCT_US:361462002

Notochord
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000048
Subclass_of: Embryonic Structures
Synonym: Chorda dorsalis
Synonym: Chordamesoderm
Synonym: Notochords
Synonym: Structure of notochord
Synonym: Structure of notochord (body structure)
Synonym: notochord
Tree Number: T1.1.15
database_cross_reference: CHV:0000008790
database_cross_reference: FMA:85521
database_cross_reference: LCH:U003269
database_cross_reference: LCH_NW:sh85092813
database_cross_reference: MSH:D009672
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12463
database_cross_reference: SNM:T-89310
database_cross_reference: SNMI:T-F6410
database_cross_reference: SNOMEDCT_US:37222002

Ovum
type: Class
subclass of: Embryonic Structures
subclass of: Germ Cells
PMOID: PMO:00000049
Subclass_of: Embryonic Structures
Subclass_of: Germ Cells
Synonym: Egg
Synonym: Egg (cell)
Synonym: Egg, NOS
Synonym: Egg, Unfertilized
Synonym: Eggs, Unfertilized
Synonym: Female gamete
Synonym: Fertilized oocyte
Synonym: Human egg
Synonym: Mature ovum
Synonym: Oocytes
Tree Number: T1.1.16
Tree Number: T2.15.2
database_cross_reference: AOD:0000017390
database_cross_reference: CHV:0000009132
database_cross_reference: CSP:1138-3157
database_cross_reference: DRUGBANK:DB10529
database_cross_reference: FMA:67343
database_cross_reference: LCH:U003418
database_cross_reference: LCH_NW:sh85096271
database_cross_reference: LNC:LP14834-3
database_cross_reference: LNC:LP30698-2
database_cross_reference: LNC:LP7192-0
database_cross_reference: LNC:MTHU009318
database_cross_reference: MSH:D010063
database_cross_reference: MTH:U002129
database_cross_reference: NCI:C12598
database_cross_reference: RCD:XC0AT
database_cross_reference: SNM:T-87500
database_cross_reference: SNMI:T-87500
database_cross_reference: SNMI:T-87501
database_cross_reference: SNOMEDCT_US:263828003
database_cross_reference: SNOMEDCT_US:308796009
database_cross_reference: SNOMEDCT_US:60080006
database_cross_reference: SNOMEDCT_US:73153001
database_cross_reference: UWDA:67343

Egg Yolk
type: Class
subclass of: Ovum
PMOID: PMO:00000050
Subclass_of: Ovum
Synonym: Egg yolk
Synonym: Food - Animal Products and Poultry Products, Egg, Yolk Gallus sp.
Tree Number: T1.1.16.1
database_cross_reference: DRUGBANK:DB10530

Vitelline Membrane
type: Class
subclass of: Ovum
PMOID: PMO:00000051
Subclass_of: Ovum
Synonym: Membrane, Vitelline
Synonym: Membranes, Vitelline
Synonym: Vitelline Membranes
Synonym: vitelline membrane
Tree Number: T1.1.16.2
database_cross_reference: CSP:2404-6229
database_cross_reference: GO:GO:0035805
database_cross_reference: MSH:D014817

Zona Pellucida
type: Class
subclass of: Ovum
subclass of: Extracellular Matrix
PMOID: PMO:00000052
Subclass_of: Extracellular Matrix
Subclass_of: Ovum
Synonym: Zona pellucida
Synonym: zona pellucida
Tree Number: T1.1.16.3
Tree Number: T1.4.5.2.1
Tree Number: T2.15.2.3
Tree Number: T2.8.5.2.1
database_cross_reference: CHV:0000013283
database_cross_reference: CSP:1138-3157
database_cross_reference: FMA:18674
database_cross_reference: GO:GO:0035805
database_cross_reference: LCH_NW:sh88007451
database_cross_reference: MSH:D015044
database_cross_reference: NCI:C33896
database_cross_reference: UWDA:18674

Placenta
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000053
Subclass_of: Embryonic Structures
Synonym: PLACENTA
Synonym: Placent
Synonym: Placenta, NOS
Synonym: Placental
Synonym: Placental structure
Synonym: Placental structure (body structure)
Synonym: Placentas
Synonym: Placentoma, Normal
Synonym: Placentome
Synonym: Placentomes
Tree Number: T1.1.17
database_cross_reference: AOD:0000017034
database_cross_reference: CHV:0000009778
database_cross_reference: CSP:2402-4971
database_cross_reference: CST:ENDO/PLAC
database_cross_reference: FMA:63934
database_cross_reference: LCH:U003693
database_cross_reference: LCH_NW:sh85102565
database_cross_reference: LNC:LP200062-0
database_cross_reference: LNC:LP20772-7
database_cross_reference: LNC:LP208379-0
database_cross_reference: LNC:LP7477-5
database_cross_reference: LNC:LP7484-1
database_cross_reference: LNC:MTHU002985
database_cross_reference: MSH:D010920
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13272
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13272
database_cross_reference: NCI_NCI-GLOSS:CDR0000045017
database_cross_reference: PSY:39040
database_cross_reference: RCD:7N613
database_cross_reference: SNM:T-88100
database_cross_reference: SNMI:T-F1100
database_cross_reference: SNMI:T-F1550
database_cross_reference: SNOMEDCT_US:62669004
database_cross_reference: SNOMEDCT_US:78067005
database_cross_reference: SNOMEDCT_VET:345231000009100

Decidua
type: Class
subclass of: Placenta
PMOID: PMO:00000054
Subclass_of: Placenta
Synonym: Decidous membrane
Synonym: Decidua Graviditas
Synonym: Decidua structure
Synonym: Decidua structure (body structure)
Synonym: Decidua, NOS
Synonym: Decidual
Synonym: Deciduas
Synonym: Deciduum
Synonym: Endometrial decidua
Synonym: Endometrial decidua (body structure)
Tree Number: T1.1.17.2
database_cross_reference: CHV:0000003643
database_cross_reference: CSP:4001-0037
database_cross_reference: FMA:85538
database_cross_reference: LCH:U001282
database_cross_reference: LCH_NW:sh86005483
database_cross_reference: MSH:D003656
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32425
database_cross_reference: SNM:T-84500
database_cross_reference: SNM:T-88205
database_cross_reference: SNMI:T-83480
database_cross_reference: SNMI:T-F1205
database_cross_reference: SNOMEDCT_US:34863009
database_cross_reference: SNOMEDCT_US:72649005

Deciduoma
type: Class
subclass of: Decidua
PMOID: PMO:00000055
Subclass_of: Decidua
Synonym: Deciduomas
Synonym: Neoplasm of Placenta
Synonym: Neoplasm of placenta
Synonym: Neoplasm of placenta (disorder)
Synonym: Neoplasm of the Placenta
Synonym: Placenta Neoplasm
Synonym: Placenta Neoplasms
Synonym: Placenta Tumor
Synonym: Placenta Tumors
Synonym: Placental Neoplasm
Tree Number: T1.1.17.2.1
database_cross_reference: CSP:2403-0590
database_cross_reference: MDR:10035140
database_cross_reference: MDR:10035141
database_cross_reference: MDR:10061349
database_cross_reference: MEDCIN:97460
database_cross_reference: MSH:D033301
database_cross_reference: NCI:C4858
database_cross_reference: SNOMEDCT_US:126920004

Urachus
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000056
Subclass_of: Embryonic Structures
Synonym: Structure of urachus
Synonym: Structure of urachus (body structure)
Synonym: median umbilical ligament
Synonym: urachus
Tree Number: T1.1.18
database_cross_reference: CHV:0000012746
database_cross_reference: FMA:70343
database_cross_reference: LCH:U004846
database_cross_reference: LCH_NW:sh85141256
database_cross_reference: MSH:D014497
database_cross_reference: MTH:U002335
database_cross_reference: NCI:C12338
database_cross_reference: NCI_NCI-GLOSS:CDR0000044354
database_cross_reference: NCI_NCI-GLOSS:CDR0000520556
database_cross_reference: RCD:Xa0EV
database_cross_reference: SNM:T-74120
database_cross_reference: SNMI:T-F6625
database_cross_reference: SNOMEDCT_US:14105008
database_cross_reference: UWDA:70343

Vitelline Duct
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000057
Subclass_of: Embryonic Structures
Synonym: Duct, Omphalomesenteric
Synonym: Duct, Vitelline
Synonym: Ducts, Omphalomesenteric
Synonym: Ducts, Vitelline
Synonym: Omphalomesenteric Duct
Synonym: Omphalomesenteric Ducts
Synonym: Omphalomesenteric duct
Synonym: Structure of yolk stalk
Synonym: Structure of yolk stalk (body structure)
Synonym: Vitelline Ducts
Tree Number: T1.1.19
database_cross_reference: CHV:0000013063
database_cross_reference: MSH:D014816
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-88450
database_cross_reference: SNM:T-88850
database_cross_reference: SNMI:T-F1450
database_cross_reference: SNOMEDCT_US:41629008

Wolffian Ducts
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000058
Subclass_of: Embryonic Structures
Synonym: Duct, Mesonephric
Synonym: Duct, Wolffian
Synonym: Ducts, Mesonephric
Synonym: Ducts, Wolffian
Synonym: Mesonephric Duct
Synonym: Mesonephric Ducts
Synonym: Mesonephric duct
Synonym: Structure of mesonephric duct
Synonym: Structure of mesonephric duct (body structure)
Synonym: Wolffian Duct
Tree Number: T1.1.20
database_cross_reference: CHV:0000013177
database_cross_reference: MSH:D014928
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26469
database_cross_reference: SNM:T-89360
database_cross_reference: SNMI:T-F6460
database_cross_reference: SNOMEDCT_US:49222007

Zygote
type: Class
subclass of: Embryonic Structures
subclass of: Ovum
PMOID: PMO:00000059
Subclass_of: Embryonic Structures
Subclass_of: Ovum
Synonym: Egg, Fertilized
Synonym: Eggs, Fertilized
Synonym: Fertilised ovum
Synonym: Fertilized Egg
Synonym: Fertilized Eggs
Synonym: Fertilized Ovum
Synonym: Fertilized Ovums
Synonym: Fertilized ovum
Synonym: Ovum, Fertilized
Synonym: Structure of zygote
Tree Number: T1.1.21
Tree Number: T2.15.2.4
database_cross_reference: AOD:0000002008
database_cross_reference: AOD:0000021684
database_cross_reference: AOD:0000021685
database_cross_reference: CHV:0000013291
database_cross_reference: FMA:72395
database_cross_reference: LCH:U005093
database_cross_reference: LCH_NW:sh85150089
database_cross_reference: MSH:D015053
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12601
database_cross_reference: SNM:T-88150
database_cross_reference: SNM:T-89005
database_cross_reference: SNMI:T-F5106
database_cross_reference: SNOMEDCT_US:57323001
database_cross_reference: UWDA:72395

Limb Buds
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000060
Subclass_of: Embryonic Structures
Synonym: Bud, Limb
Synonym: Buds, Limb
Synonym: Limb Bud
Synonym: Limb bud
Synonym: limb bud
Tree Number: T1.1.22
database_cross_reference: CHV:0000027618
database_cross_reference: FMA:296780
database_cross_reference: MSH:D018878
database_cross_reference: NCI:C34203

Organizers, Embryonic
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000061
Subclass_of: Embryonic Structures
Synonym: Embryo Organizer
Synonym: Embryo Organizers
Synonym: Embryonic Organizer
Synonym: Embryonic Organizers
Synonym: Organizer, Embryo
Synonym: Organizer, Embryonic
Synonym: Organizers, Embryo
Tree Number: T1.1.23
database_cross_reference: MSH:D020897

Primitive Streak
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000062
Subclass_of: Embryonic Structures
Synonym: Primitive Streaks
Synonym: Primitive streak
Synonym: Primitive streak (body structure)
Synonym: Streak, Primitive
Synonym: Streaks, Primitive
Tree Number: T1.1.24
database_cross_reference: FMA:293110
database_cross_reference: MSH:D054240
database_cross_reference: NCI:C28402
database_cross_reference: SNOMEDCT_US:361438007

Neural Plate
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000063
Subclass_of: Embryonic Structures
Synonym: Neural Plates
Synonym: Neural plate
Synonym: Plate, Neural
Synonym: Plates, Neural
Synonym: neural plate
Tree Number: T1.1.25
database_cross_reference: CHV:0000052618
database_cross_reference: CSP:1016-7347
database_cross_reference: FMA:293879
database_cross_reference: MSH:D054258
database_cross_reference: NCI:C34225
database_cross_reference: NEU:1362

Neural Tube
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000064
Subclass_of: Embryonic Structures
Synonym: Embryonic neuraxis
Synonym: Neural Tubes
Synonym: Neural tube
Synonym: Neural tube structure
Synonym: Neural tube structure (body structure)
Synonym: Tube, Neural
Synonym: Tubes, Neural
Synonym: medullary tube
Synonym: neural tube
Synonym: neural tubes
Tree Number: T1.1.26
database_cross_reference: AOD:0000017027
database_cross_reference: AOD:0000027665
database_cross_reference: CHV:0000022591
database_cross_reference: CSP:1016-7347
database_cross_reference: FMA:293882
database_cross_reference: LCH_NW:sh85091098
database_cross_reference: MSH:D054259
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34226
database_cross_reference: NEU:1365
database_cross_reference: SNM:T-89110
database_cross_reference: SNMI:T-F6110
database_cross_reference: SNOMEDCT_US:60271003

Gestational Sac
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000065
Subclass_of: Embryonic Structures
Synonym: Gestation Sac
Synonym: Gestation Sacs
Synonym: Gestational Sacs
Synonym: Gestational sac
Synonym: Sac, Gestation
Synonym: Sac, Gestational
Synonym: Sacs, Gestation
Synonym: Sacs, Gestational
Synonym: gestational sac
Synonym: sac gestational
Tree Number: T1.1.27
database_cross_reference: CHV:0000039073
database_cross_reference: LNC:LP7273-8
database_cross_reference: LNC:MTHU002950
database_cross_reference: MSH:D058746
database_cross_reference: NCI:C82951

Pronephros
type: Class
subclass of: Embryonic Structures
PMOID: PMO:00000066
Subclass_of: Embryonic Structures
Synonym: Pronephric structure
Synonym: Pronephric structure (body structure)
Synonym: Pronephroi
Tree Number: T1.1.28
database_cross_reference: FMA:72170
database_cross_reference: MSH:D060910
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34280
database_cross_reference: SNM:T-89340
database_cross_reference: SNMI:T-F6440
database_cross_reference: SNOMEDCT_US:16421008

Head Kidney
type: Class
subclass of: Pronephros
PMOID: PMO:00000067
Subclass_of: Pronephros
Synonym: Anterior Kidney
Synonym: Anterior Kidneys
Synonym: Head Kidneys
Synonym: Kidney, Anterior
Synonym: Kidney, Head
Synonym: Kidneys, Anterior
Synonym: Kidneys, Head
Tree Number: T1.1.28.1
database_cross_reference: MSH:D060226

Body Regions
type: Class
subclass of: Anatomical Structure
PMOID: PMO:00000068
Subclass_of: Anatomical Structure
Tree Number: T1.2

Breast
type: Class
subclass of: Body Regions
PMOID: PMO:00000069
Subclass_of: Body Regions
Synonym: 04 BREASTS
Synonym: BREAST
Synonym: BREASTS
Synonym: Breast anatomy
Synonym: Breast anatomy (body structure)
Synonym: Breast structure
Synonym: Breast structure (body structure)
Synonym: Breast, NOS
Synonym: Breasts
Synonym: Mamma
Tree Number: T1.2.1
database_cross_reference: AOD:0000001800
database_cross_reference: CCPSS:0003968
database_cross_reference: CHV:0000002151
database_cross_reference: CSP:2587-3889
database_cross_reference: FMA:9601
database_cross_reference: LCH:U000673
database_cross_reference: LCH_NW:sh85016677
database_cross_reference: LNC:LA4255-1
database_cross_reference: LNC:LP199961-6
database_cross_reference: LNC:LP29849-4
database_cross_reference: LNC:LP7086-4
database_cross_reference: LNC:MTHU001046
database_cross_reference: LNC:MTHU011382
database_cross_reference: MSH:D001940
database_cross_reference: MTH:U001764
database_cross_reference: NCI:C12971
database_cross_reference: NCI:C43595
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12971
database_cross_reference: NCI_NCI-GLOSS:CDR0000044560
database_cross_reference: NCI_NCI-GLOSS:CDR0000304766
database_cross_reference: NCI_NICHD:C12971
database_cross_reference: OMIM:MTHU001433
database_cross_reference: PSY:06920
database_cross_reference: RCD:7N12.
database_cross_reference: RCD:XM0QG
database_cross_reference: SNM:T-04000
database_cross_reference: SNM:U000415
database_cross_reference: SNMI:T-04000
database_cross_reference: SNOMEDCT_US:272669003
database_cross_reference: SNOMEDCT_US:361079003
database_cross_reference: SNOMEDCT_US:76752008
database_cross_reference: UWDA:9601

Nipples
type: Class
subclass of: Breast
PMOID: PMO:00000070
Subclass_of: Breast
Synonym: NIPPLE
Synonym: Nipple
Synonym: Nipple (Anatomy)
Synonym: Nipple (body structure)
Synonym: Nipple anatomy
Synonym: Nipple anatomy (body structure)
Synonym: Nipple structure
Synonym: Nipple structure (body structure)
Synonym: Papilla mammaria
Synonym: Papillary part of breast
Tree Number: T1.2.1.1
database_cross_reference: AOD:0000017152
database_cross_reference: CHV:0000008725
database_cross_reference: FMA:67771
database_cross_reference: LCH_NW:sh2009007031
database_cross_reference: MSH:D009558
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12299
database_cross_reference: NCI_CDISC:C12299
database_cross_reference: NCI_NCI-GLOSS:CDR0000304735
database_cross_reference: NCI_NICHD:C12299
database_cross_reference: RCD:XE0Jw
database_cross_reference: RCD:Xa0wF
database_cross_reference: SNM:T-04100
database_cross_reference: SNMI:T-04100
database_cross_reference: SNOMEDCT_US:24142002
database_cross_reference: SNOMEDCT_US:279007000
database_cross_reference: SNOMEDCT_US:361080000
database_cross_reference: SNOMEDCT_US:367340005
database_cross_reference: UMD:33-768
database_cross_reference: UWDA:67771

Mammary Glands, Human
type: Class
subclass of: Breast
subclass of: Exocrine Glands
PMOID: PMO:00000071
Subclass_of: Breast
Subclass_of: Exocrine Glands
Synonym: Gland, Human Mammary
Synonym: Gland, Mammary
Synonym: Glands, Human Mammary
Synonym: Glands, Mammary
Synonym: Glandula mammaria
Synonym: Human Mammary Gland
Synonym: Human Mammary Glands
Synonym: MAMMARY GLAND
Synonym: Mammary
Synonym: Mammary Gland
Tree Number: T1.2.1.2
Tree Number: T1.3.6.9
database_cross_reference: AOD:0000027713
database_cross_reference: CHV:0000052712
database_cross_reference: CSP:2587-3889
database_cross_reference: FMA:286452
database_cross_reference: FMA:57983
database_cross_reference: LCH_NW:sh85080275
database_cross_reference: MSH:D042361
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12367
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12367
database_cross_reference: NCI_NCI-GLOSS:CDR0000415575
database_cross_reference: NCI_NICHD:C12367
database_cross_reference: PSY:29320
database_cross_reference: RCD:7N12.
database_cross_reference: SNM:T-04000
database_cross_reference: SNMI:T-04000
database_cross_reference: SNOMEDCT_US:76752008
database_cross_reference: SNOMEDCT_VET:277791000009109
database_cross_reference: UWDA:57983

Extremities
type: Class
subclass of: Body Regions
PMOID: PMO:00000072
Subclass_of: Body Regions
Synonym: Extremities (Anatomy)
Synonym: Extremity
Synonym: Extremity (body structure)
Synonym: Extremity -RETIRED-
Synonym: Extremity, NOS
Synonym: LIMB
Synonym: Limb
Synonym: Limb structure
Synonym: Limb structure (body structure)
Synonym: Limb, NOS
Tree Number: T1.2.2
database_cross_reference: AOD:0000004703
database_cross_reference: AOD:0000017103
database_cross_reference: CHV:0000004807
database_cross_reference: CSP:2715-5305
database_cross_reference: FMA:7182
database_cross_reference: LCH:U006431
database_cross_reference: LCH_NW:sh85046619
database_cross_reference: LNC:LA3977-1
database_cross_reference: LNC:LP121777-9
database_cross_reference: LNC:LP199969-9
database_cross_reference: LNC:LP29945-0
database_cross_reference: LNC:LP7216-7
database_cross_reference: LNC:LP7395-9
database_cross_reference: LNC:MTHU001429
database_cross_reference: LNC:MTHU002838
database_cross_reference: LNC:MTHU011975
database_cross_reference: MSH:D005121
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12429
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12429
database_cross_reference: NCI_NICHD:C12429
database_cross_reference: OMIM:MTHU000040
database_cross_reference: RCD:X74Yt
database_cross_reference: RCD:Xa1Z8
database_cross_reference: SNM:T-Y1800
database_cross_reference: SNMI:T-D0300
database_cross_reference: SNOMEDCT_US:123169005
database_cross_reference: SNOMEDCT_US:66019005
database_cross_reference: UWDA:7182

Amputation Stumps
type: Class
subclass of: Extremities
PMOID: PMO:00000073
Subclass_of: Extremities
Synonym: Amputation Stump
Synonym: Amputation stump
Synonym: Amputation stump (body structure)
Synonym: Amputation stump (morphologic abnormality)
Synonym: Amputation stumps
Synonym: Stump
Synonym: Stump, Amputation
Synonym: Stumps, Amputation
Synonym: amputation stump
Synonym: stump
Tree Number: T1.2.2.1
database_cross_reference: AOD:0000008176
database_cross_reference: CHV:0000001056
database_cross_reference: LCH:U000215
database_cross_reference: MSH:D000672
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C96294
database_cross_reference: RCD:Xa9LR
database_cross_reference: SNM:M-14850
database_cross_reference: SNMI:M-17080
database_cross_reference: SNOMEDCT_US:38033009

Upper Extremity
type: Class
subclass of: Extremities
PMOID: PMO:00000074
Subclass_of: Extremities
Synonym: Arm
Synonym: D8 UPPER EXTREMITIES
Synonym: Extremities, Upper
Synonym: Extremity, Upper
Synonym: Extremity-upper
Synonym: FORELIMB
Synonym: Fore limb
Synonym: Forelimb
Synonym: Forelimb, NOS
Synonym: LIMB, UPPER
Tree Number: T1.2.2.2
database_cross_reference: AOD:0000027657
database_cross_reference: AOD:0000027658
database_cross_reference: CHV:0000055073
database_cross_reference: CSP:2715-5391
database_cross_reference: CST:BODY/UE
database_cross_reference: FMA:7183
database_cross_reference: LCH:U006433
database_cross_reference: LNC:LA18113-3
database_cross_reference: LNC:LP200031-5
database_cross_reference: LNC:LP207499-7
database_cross_reference: LNC:LP29957-5
database_cross_reference: LNC:MTHU011974
database_cross_reference: MSH:D034941
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12671
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12671
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C12671
database_cross_reference: RCD:Xa1ZA
database_cross_reference: SNM:T-Y8000
database_cross_reference: SNM:U000523
database_cross_reference: SNMI:T-D8000
database_cross_reference: SNOMEDCT_US:53120007
database_cross_reference: UWDA:7183

Arm
type: Class
subclass of: Upper Extremity
PMOID: PMO:00000075
Subclass_of: Upper Extremity
Synonym: D8 UPPER EXTREMITIES
Synonym: Extremities, Upper
Synonym: Extremity, Upper
Synonym: Extremity-upper
Synonym: FORELIMB
Synonym: Fore limb
Synonym: Forelimb
Synonym: Forelimb, NOS
Synonym: LIMB, UPPER
Synonym: Limb, Upper
Tree Number: T1.2.2.2.1
database_cross_reference: AOD:0000027657
database_cross_reference: AOD:0000027658
database_cross_reference: CHV:0000055073
database_cross_reference: CSP:2715-5391
database_cross_reference: CST:BODY/UE
database_cross_reference: FMA:7183
database_cross_reference: LCH:U006433
database_cross_reference: LNC:LA18113-3
database_cross_reference: LNC:LP200031-5
database_cross_reference: LNC:LP207499-7
database_cross_reference: LNC:LP29957-5
database_cross_reference: LNC:MTHU011974
database_cross_reference: MSH:D034941
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12671
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12671
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C12671
database_cross_reference: RCD:Xa1ZA
database_cross_reference: SNM:T-Y8000
database_cross_reference: SNM:U000523
database_cross_reference: SNMI:T-D8000
database_cross_reference: SNOMEDCT_US:53120007
database_cross_reference: UWDA:7183

Axilla
type: Class
subclass of: Upper Extremity
PMOID: PMO:00000076
Subclass_of: Upper Extremity
Synonym: Entire axilla
Synonym: Entire axilla (body structure)
Tree Number: T1.2.2.2.2
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:182333009

Elbow
type: Class
subclass of: Upper Extremity
PMOID: PMO:00000077
Subclass_of: Upper Extremity
Synonym: Elbow, NOS
Synonym: Entire elbow
Synonym: Entire elbow region
Synonym: Entire elbow region (body structure)
Tree Number: T1.2.2.2.3
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:T-D8300
database_cross_reference: SNOMEDCT_US:76248009

Forearm
type: Class
subclass of: Upper Extremity
PMOID: PMO:00000078
Subclass_of: Upper Extremity
Synonym: Antebrachial region
Synonym: Antebrachium
Synonym: Antebrachiums
Synonym: FOREARM
Synonym: Forearm structure
Synonym: Forearm structure (body structure)
Synonym: Forearm, NOS
Synonym: Forearms
Synonym: Intermediate segment of free upper limb
Synonym: Pair of forearm
Tree Number: T1.2.2.2.4
database_cross_reference: AOD:0000017007
database_cross_reference: CCPSS:0025868
database_cross_reference: CHV:0000005202
database_cross_reference: FMA:268887
database_cross_reference: FMA:9663
database_cross_reference: LCH:U001855
database_cross_reference: LCH_NW:sh85050484
database_cross_reference: LNC:LP199974-9
database_cross_reference: LNC:LP207500-2
database_cross_reference: LNC:LP7249-8
database_cross_reference: LNC:MTHU002680
database_cross_reference: MSH:D005542
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32628
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C32628
database_cross_reference: NCI_NICHD:C32628
database_cross_reference: RCD:Xa8Ss
database_cross_reference: SNM:T-Y8500
database_cross_reference: SNMI:T-D8500
database_cross_reference: SNOMEDCT_US:14975008
database_cross_reference: SNOMEDCT_VET:14975008
database_cross_reference: UWDA:9663

Hand
type: Class
subclass of: Upper Extremity
PMOID: PMO:00000079
Subclass_of: Upper Extremity
Synonym: HAND
Synonym: Hand (Anatomy)
Synonym: Hand, NOS
Synonym: Hands
Synonym: Manus
Synonym: Terminal segment of free upper limb
Synonym: hand
Synonym: hand structure
Synonym: hands
Synonym: manus
Tree Number: T1.2.2.2.5
database_cross_reference: AOD:0000002469
database_cross_reference: CHV:0000005789
database_cross_reference: CSP:2715-5520
database_cross_reference: DRUGBANK:DB00898
database_cross_reference: DRUGBANK:DB08604
database_cross_reference: FMA:9712
database_cross_reference: LCH:U002075
database_cross_reference: LCH_NW:sh85058615
database_cross_reference: LNC:LA16719-9
database_cross_reference: LNC:LP207503-6
database_cross_reference: LNC:LP221491-6
database_cross_reference: LNC:LP7279-5
database_cross_reference: LNC:MTHU002685
database_cross_reference: MSH:D006225
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32712
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C32712
database_cross_reference: NCI_NICHD:C32712
database_cross_reference: OMIM:MTHU000072
database_cross_reference: PSY:22200
database_cross_reference: RCD:Xa8St
database_cross_reference: SNM:T-Y8700
database_cross_reference: SNMI:T-D8700
database_cross_reference: SNOMEDCT_US:85562004
database_cross_reference: UWDA:9712

Shoulder
type: Class
subclass of: Upper Extremity
PMOID: PMO:00000084
Subclass_of: Upper Extremity
Tree Number: T1.2.2.2.6

Lower Extremity
type: Class
subclass of: Extremities
PMOID: PMO:00000085
Subclass_of: Extremities
Synonym: D9 LOWER EXTREMITIES
Synonym: Extremities, Lower
Synonym: Extremity, Lower
Synonym: Extremity-lower
Synonym: HINDLIMB
Synonym: Hind Limb
Synonym: Hind limb
Synonym: Hindlimb
Synonym: Hindlimb, NOS
Synonym: Hindquarter
Tree Number: T1.2.2.3
database_cross_reference: AOD:0000027660
database_cross_reference: AOD:0000027661
database_cross_reference: CCPSS:1001127
database_cross_reference: CHV:0000007269
database_cross_reference: CST:BODY/LE
database_cross_reference: FMA:7184
database_cross_reference: LCH:U006432
database_cross_reference: LNC:LA18112-5
database_cross_reference: LNC:LP199985-5
database_cross_reference: LNC:LP207495-5
database_cross_reference: LNC:LP29948-4
database_cross_reference: LNC:MTHU011970
database_cross_reference: MSH:D035002
database_cross_reference: MTH:U003308
database_cross_reference: NCI:C12742
database_cross_reference: NCI:C77625
database_cross_reference: NCI_CDISC:C12742
database_cross_reference: NCI_CDISC:C77625
database_cross_reference: NCI_NICHD:C12742
database_cross_reference: RCD:7NB1.
database_cross_reference: RCD:Xa1Z9
database_cross_reference: SNM:T-Y9000
database_cross_reference: SNM:U000524
database_cross_reference: SNMI:T-D9000
database_cross_reference: SNOMEDCT_US:61685007
database_cross_reference: SNOMEDCT_VET:116013008
database_cross_reference: SNOMEDCT_VET:61685007
database_cross_reference: UWDA:7184

Buttocks
type: Class
subclass of: Lower Extremity
PMOID: PMO:00000086
Subclass_of: Lower Extremity
Tree Number: T1.2.2.3.1

Foot
type: Class
subclass of: Lower Extremity
PMOID: PMO:00000087
Subclass_of: Lower Extremity
Synonym: FEET
Synonym: FOOT
Synonym: Feet
Synonym: Feet (Anatomy)
Synonym: Foot structure
Synonym: Foot structure (body structure)
Synonym: Foot, NOS
Synonym: Pedal
Synonym: Pes
Synonym: Terminal segment of free lower limb
Tree Number: T1.2.2.3.2
database_cross_reference: AOD:0000005175
database_cross_reference: CCPSS:1006709
database_cross_reference: CHV:0000005187
database_cross_reference: CSP:2715-5477
database_cross_reference: FMA:9664
database_cross_reference: LCH:U001850
database_cross_reference: LCH_NW:sh85050352
database_cross_reference: LNC:LP207497-1
database_cross_reference: LNC:LP221475-9
database_cross_reference: LNC:LP7245-6
database_cross_reference: LNC:MTHU002679
database_cross_reference: MSH:D005528
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32622
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C32622
database_cross_reference: NCI_NICHD:C32622
database_cross_reference: OMIM:MTHU000075
database_cross_reference: PSY:19500
database_cross_reference: RCD:Xa1fX
database_cross_reference: RCD:Xa8Sz
database_cross_reference: SNM:T-Y9700
database_cross_reference: SNMI:T-D9700
database_cross_reference: SNOMEDCT_US:56459004
database_cross_reference: UWDA:9664

Hip
type: Class
subclass of: Lower Extremity
PMOID: PMO:00000094
Subclass_of: Lower Extremity
Synonym: Bone structure of hip
Synonym: Bone structure of hip (body structure)
Synonym: Coxa
Synonym: Coxas
Synonym: D25 HIPS
Synonym: HIP
Synonym: HIPS
Synonym: Hip region
Synonym: Hip region structure
Synonym: Hip region structure (body structure)
Tree Number: T1.2.2.3.3
database_cross_reference: AOD:0000004701
database_cross_reference: CCPSS:1017313
database_cross_reference: CHV:0000006140
database_cross_reference: CSP:2715-4488
database_cross_reference: FMA:24964
database_cross_reference: LNC:LA3973-0
database_cross_reference: LNC:LP199979-8
database_cross_reference: LNC:LP207492-2
database_cross_reference: LNC:LP7348-8
database_cross_reference: LNC:MTHU002686
database_cross_reference: MSH:D006615
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C64193
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C64193
database_cross_reference: NCI_NICHD:C64193
database_cross_reference: PSY:23020
database_cross_reference: RCD:Xa1qf
database_cross_reference: RCD:Xa8Sx
database_cross_reference: RCD:XaABt
database_cross_reference: SNM:T-Y1500
database_cross_reference: SNMI:T-D2500
database_cross_reference: SNOMEDCT_US:24136001
database_cross_reference: SNOMEDCT_US:29836001
database_cross_reference: SNOMEDCT_US:304907005
database_cross_reference: UWDA:24964

Knee
type: Class
subclass of: Lower Extremity
PMOID: PMO:00000095
Subclass_of: Lower Extremity
Synonym: Bone structure of knee
Synonym: Bone structure of knee (body structure)
Synonym: Genu
Synonym: KNEE
Synonym: Knee, NOS
Synonym: genu
Synonym: knee
Synonym: knee s
Synonym: knee's
Synonym: knee(s)
Tree Number: T1.2.2.3.4
database_cross_reference: AOD:0000008182
database_cross_reference: CCPSS:1005647
database_cross_reference: CHV:0000007124
database_cross_reference: CHV:0000021456
database_cross_reference: CSP:2715-4875
database_cross_reference: FMA:24974
database_cross_reference: LCH:U002590
database_cross_reference: LCH_NW:sh85072671
database_cross_reference: LNC:LA22232-5
database_cross_reference: LNC:LP199984-8
database_cross_reference: LNC:LP207494-8
database_cross_reference: LNC:LP7381-9
database_cross_reference: LNC:MTHU002687
database_cross_reference: MSH:D007717
database_cross_reference: MTH:NOCODE
database_cross_reference: PSY:27440
database_cross_reference: SNM:T-Y9200
database_cross_reference: SNMI:T-D9200
database_cross_reference: SNOMEDCT_US:304679005
database_cross_reference: SNOMEDCT_VET:304679005
database_cross_reference: UWDA:24974

Leg
type: Class
subclass of: Lower Extremity
PMOID: PMO:00000096
Subclass_of: Lower Extremity
Synonym: D9 LOWER EXTREMITIES
Synonym: Extremities, Lower
Synonym: Extremity, Lower
Synonym: Extremity-lower
Synonym: HINDLIMB
Synonym: Hind Limb
Synonym: Hind limb
Synonym: Hindlimb
Synonym: Hindlimb, NOS
Synonym: Hindquarter
Tree Number: T1.2.2.3.5
database_cross_reference: AOD:0000027660
database_cross_reference: AOD:0000027661
database_cross_reference: CCPSS:1001127
database_cross_reference: CHV:0000007269
database_cross_reference: CST:BODY/LE
database_cross_reference: FMA:7184
database_cross_reference: LCH:U006432
database_cross_reference: LNC:LA18112-5
database_cross_reference: LNC:LP199985-5
database_cross_reference: LNC:LP207495-5
database_cross_reference: LNC:LP29948-4
database_cross_reference: LNC:MTHU011970
database_cross_reference: MSH:D035002
database_cross_reference: MTH:U003308
database_cross_reference: NCI:C12742
database_cross_reference: NCI:C77625
database_cross_reference: NCI_CDISC:C12742
database_cross_reference: NCI_CDISC:C77625
database_cross_reference: NCI_NICHD:C12742
database_cross_reference: RCD:7NB1.
database_cross_reference: RCD:Xa1Z9
database_cross_reference: SNM:T-Y9000
database_cross_reference: SNM:U000524
database_cross_reference: SNMI:T-D9000
database_cross_reference: SNOMEDCT_US:61685007
database_cross_reference: SNOMEDCT_VET:116013008
database_cross_reference: SNOMEDCT_VET:61685007
database_cross_reference: UWDA:7184

Thigh
type: Class
subclass of: Lower Extremity
PMOID: PMO:00000097
Subclass_of: Lower Extremity
Synonym: Entire thigh
Synonym: Entire thigh (body structure)
Tree Number: T1.2.2.3.6
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:302544002

Head
type: Class
subclass of: Body Regions
PMOID: PMO:00000098
Subclass_of: Body Regions
Synonym: Caput (caudatus)
Synonym: Caput nuclei caudati
Synonym: Caudate nuclear head
Synonym: HCd
Synonym: Head of caudate nucleus
Synonym: Structure of head of caudate nucleus
Synonym: Structure of head of caudate nucleus (body structure)
Synonym: head
Synonym: head of caudate nucleus
Synonym: head of the caudate nucleus
Tree Number: T1.2.3
database_cross_reference: FMA:61852
database_cross_reference: MTH:NOCODE
database_cross_reference: NEU:227
database_cross_reference: RCD:Xa12g
database_cross_reference: SNM:T-X3210
database_cross_reference: SNMI:T-A3210
database_cross_reference: SNOMEDCT_US:88017005

Ear
type: Class
subclass of: Head
PMOID: PMO:00000099
Subclass_of: Head
Synonym: Apparatus, Vestibulocochlear
Synonym: Auris
Synonym: EAR
Synonym: Ear (Anatomy)
Synonym: Ear and related structures
Synonym: Ear structure
Synonym: Ear structure (body structure)
Synonym: Ear-related structure
Synonym: Ears
Synonym: Organum vestibulocochleare
Tree Number: T1.2.3.1
database_cross_reference: AOD:0000004413
database_cross_reference: AOD:0000027965
database_cross_reference: CCPSS:0031468
database_cross_reference: CHV:0000004225
database_cross_reference: CHV:0000035664
database_cross_reference: CSP:0973-2108
database_cross_reference: FMA:52780
database_cross_reference: FMA:77739
database_cross_reference: LCH:U001490
database_cross_reference: LCH_NW:sh85040383
database_cross_reference: LNC:LA21929-7
database_cross_reference: LNC:LA22163-2
database_cross_reference: LNC:LP7188-8
database_cross_reference: LNC:MTHU001407
database_cross_reference: MSH:D004423
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12394
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12394
database_cross_reference: NCI_NICHD:C12394
database_cross_reference: OMIM:MTHU000052
database_cross_reference: PSY:15720
database_cross_reference: RCD:Xa05g
database_cross_reference: SNM:T-XY000
database_cross_reference: SNM:T-XY700
database_cross_reference: SNM:U000515
database_cross_reference: SNMI:T-AB000
database_cross_reference: SNOMEDCT_US:117590005
database_cross_reference: SNOMEDCT_VET:117590005
database_cross_reference: UWDA:52780
database_cross_reference: UWDA:77739

Face
type: Class
subclass of: Head
PMOID: PMO:00000100
Subclass_of: Head
Synonym: Entire face
Synonym: Entire face (body structure)
Tree Number: T1.2.3.2
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:302549007

Superficial Musculoaponeurotic System
type: Class
subclass of: Face
subclass of: Neck
PMOID: PMO:00000101
Subclass_of: Face
Subclass_of: Neck
Tree Number: T1.2.3.2.1
Tree Number: T1.2.4.1

Cheek
type: Class
subclass of: Face
PMOID: PMO:00000102
Subclass_of: Face
Synonym: Entire buccal region of face
Synonym: Entire cheek
Synonym: Entire cheek (body structure)
Tree Number: T1.2.3.2.2
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:182325008

Chin
type: Class
subclass of: Face
PMOID: PMO:00000103
Subclass_of: Face
Tree Number: T1.2.3.2.3

Eye
type: Class
subclass of: Face
PMOID: PMO:00000104
Subclass_of: Face
Synonym: ?Eye
Synonym: Bulbus oculi
Synonym: EYE
Synonym: Eye (Anatomy)
Synonym: Eye (body structure)
Synonym: Eye structure
Synonym: Eye structure (body structure)
Synonym: Eye, NOS
Synonym: Eyeball
Synonym: Eyeball structure
Tree Number: T1.2.3.2.4
database_cross_reference: AOD:0000002468
database_cross_reference: AOD:0000017567
database_cross_reference: CCPSS:0057369
database_cross_reference: CHV:0000004810
database_cross_reference: COSTAR:NOCODE
database_cross_reference: CSP:1107-6922
database_cross_reference: FMA:12513
database_cross_reference: FMA:54448
database_cross_reference: LCH:U001714
database_cross_reference: LCH_NW:sh85046642
database_cross_reference: LNC:LA14722-5
database_cross_reference: LNC:LP117007-7
database_cross_reference: LNC:LP207778-4
database_cross_reference: LNC:LP7218-3
database_cross_reference: LNC:LP7222-5
database_cross_reference: LNC:LP7797-6
database_cross_reference: LNC:MTHU000064
database_cross_reference: LNC:MTHU001409
database_cross_reference: LNC:MTHU001430
database_cross_reference: LNC:MTHU038905
database_cross_reference: MSH:D005123
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U003284
database_cross_reference: NCI:C12401
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12401
database_cross_reference: NCI_NCI-GLOSS:CDR0000350235
database_cross_reference: NCI_NICHD:C12401
database_cross_reference: OMIM:MTHU000020
database_cross_reference: PSY:18890
database_cross_reference: RCD:X74in
database_cross_reference: RCD:Xa05O
database_cross_reference: RCD:Xa0Gs
database_cross_reference: RCD:Xa1S4
database_cross_reference: SNM:T-XX000
database_cross_reference: SNMI:T-AA000
database_cross_reference: SNOMEDCT_US:276432009
database_cross_reference: SNOMEDCT_US:367568005
database_cross_reference: SNOMEDCT_US:371398005
database_cross_reference: SNOMEDCT_US:81745001
database_cross_reference: SNOMEDCT_VET:81745001
database_cross_reference: UWDA:12513
database_cross_reference: UWDA:54448

Forehead
type: Class
subclass of: Face
PMOID: PMO:00000108
Subclass_of: Face
Tree Number: T1.2.3.2.5

Mouth
type: Class
subclass of: Face
PMOID: PMO:00000109
Subclass_of: Face
Tree Number: T1.2.3.2.6

Nose
type: Class
subclass of: Face
PMOID: PMO:00000111
Subclass_of: Face
Synonym: 21 NOSE
Synonym: JAMU Sexty
Synonym: Letomint
Synonym: NASAL
Synonym: NOSE
Synonym: Nasal
Synonym: Nasal (qualifier value)
Synonym: Nasal structure
Synonym: Nasal structure (body structure)
Synonym: Naso-
Tree Number: T1.2.3.2.7
database_cross_reference: AOD:0000017227
database_cross_reference: CHV:0000008786
database_cross_reference: CSP:1996-0769
database_cross_reference: DRUGBANK:DB00388
database_cross_reference: DRUGBANK:DB00588
database_cross_reference: DRUGBANK:DB00935
database_cross_reference: DRUGBANK:DB10672
database_cross_reference: FMA:46472
database_cross_reference: LCH:U003268
database_cross_reference: LCH_NW:sh85092748
database_cross_reference: LNC:LA22156-6
database_cross_reference: LNC:LP7443-7
database_cross_reference: MSH:D009666
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12756
database_cross_reference: NCI:C27958
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12756
database_cross_reference: NCI_CDISC:C27958
database_cross_reference: NCI_NCI-GLOSS:CDR0000044061
database_cross_reference: NCI_NICHD:C12756
database_cross_reference: NCI_NICHD:C27958
database_cross_reference: OMIM:MTHU000119
database_cross_reference: PSY:34510
database_cross_reference: RCD:7N20.
database_cross_reference: RCD:X810j
database_cross_reference: RCD:Xa06M
database_cross_reference: SNM:T-21000
database_cross_reference: SNM:U000428
database_cross_reference: SNMI:T-21000
database_cross_reference: SNOMEDCT_US:260540009
database_cross_reference: SNOMEDCT_US:45206002
database_cross_reference: UWDA:46472

Parotid Region
type: Class
subclass of: Face
PMOID: PMO:00000112
Subclass_of: Face
Tree Number: T1.2.3.2.8

Nasolabial Fold
type: Class
subclass of: Face
PMOID: PMO:00000113
Subclass_of: Face
Tree Number: T1.2.3.2.9

Scalp
type: Class
subclass of: Head
PMOID: PMO:00000114
Subclass_of: Head
Synonym: SCALP
Synonym: Scalp (Anatomy)
Synonym: Scalp structure
Synonym: Scalp structure (body structure)
Synonym: Scalp, NOS
Synonym: Scalps
Synonym: scalp
Synonym: scalp anatomy
Synonym: scalping
Synonym: scalps
Tree Number: T1.2.3.3
database_cross_reference: AOD:0000016960
database_cross_reference: CHV:0000011066
database_cross_reference: CSP:2716-1466
database_cross_reference: FMA:46494
database_cross_reference: LCH:U004219
database_cross_reference: LCH_NW:sh85117928
database_cross_reference: LNC:LA18815-3
database_cross_reference: LNC:LP30549-7
database_cross_reference: LNC:MTHU015066
database_cross_reference: MSH:D012535
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C89807
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C89807
database_cross_reference: NCI_NICHD:C89807
database_cross_reference: PSY:45370
database_cross_reference: RCD:7N710
database_cross_reference: SNM:T-Y0160
database_cross_reference: SNMI:T-D1160
database_cross_reference: SNOMEDCT_US:41695006
database_cross_reference: UWDA:46494

Skull Base
type: Class
subclass of: Head
PMOID: PMO:00000115
Subclass_of: Head
Tree Number: T1.2.3.4

Cranial Fossa, Posterior
type: Class
subclass of: Skull Base
PMOID: PMO:00000116
Subclass_of: Skull Base
Tree Number: T1.2.3.4.1

Cranial Fossa, Anterior
type: Class
subclass of: Skull Base
PMOID: PMO:00000117
Subclass_of: Skull Base
Tree Number: T1.2.3.4.2

Cranial Fossa, Middle
type: Class
subclass of: Skull Base
PMOID: PMO:00000118
Subclass_of: Skull Base
Tree Number: T1.2.3.4.3

Neck
type: Class
subclass of: Body Regions
PMOID: PMO:00000119
Subclass_of: Body Regions
Synonym: Entire neck
Synonym: Entire neck (body structure)
Tree Number: T1.2.4
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:302550007

Perineum
type: Class
subclass of: Body Regions
PMOID: PMO:00000120
Subclass_of: Body Regions
Tree Number: T1.2.5

Viscera
type: Class
subclass of: Body Regions
PMOID: PMO:00000121
Subclass_of: Body Regions
Synonym: Set of viscera
Synonym: Set of viscus organs
Synonym: Viscera set
Synonym: Viscera, NOS
Synonym: Viscus
Synonym: viscera
Synonym: viscus
Tree Number: T1.2.6
database_cross_reference: AOD:0000017019
database_cross_reference: CHV:0000013025
database_cross_reference: CSP:2935-4508
database_cross_reference: FMA:55564
database_cross_reference: FMA:7085
database_cross_reference: LCH:U004963
database_cross_reference: LCH_NW:sh85143850
database_cross_reference: MSH:D014781
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C28287
database_cross_reference: NCI_NCI-GLOSS:CDR0000044633
database_cross_reference: SNM:T-Y5000
database_cross_reference: SNMI:T-D4030
database_cross_reference: SNOMEDCT_US:19203006
database_cross_reference: UWDA:55564
database_cross_reference: UWDA:7085

Transplants
type: Class
subclass of: Body Regions
PMOID: PMO:00000122
Subclass_of: Body Regions
Synonym: 155 TRANSPLANTS
Synonym: GRAFT
Synonym: Graft
Synonym: Graft, NOS
Synonym: Grafts
Synonym: TRANSPLANTS
Synonym: Transplant
Synonym: Transplant (body structure)
Synonym: Transplant, NOS
Synonym: Transplanted organ
Tree Number: T1.2.7
database_cross_reference: CHV:0000029559
database_cross_reference: LNC:LP134079-5
database_cross_reference: LNC:MTHU041680
database_cross_reference: MSH:D019737
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12981
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C45416
database_cross_reference: NCI_FDA:290
database_cross_reference: NCI_FDA:C45416
database_cross_reference: NCI_NCI-GLOSS:CDR0000046373
database_cross_reference: NCI_NCPDP:C45416
database_cross_reference: SNMI:M-15500
database_cross_reference: SNOMEDCT_US:24486003

Allografts
type: Class
subclass of: Transplants
PMOID: PMO:00000123
Subclass_of: Transplants
Synonym: Allogeneic graft
Synonym: Allograft
Synonym: Allograft (substance)
Synonym: Allograft -RETIRED-
Synonym: Allograft surgical material
Synonym: Homograft
Synonym: Homografts
Synonym: Homologous Transplant
Synonym: Homologous Transplants
Synonym: Homologous graft
Tree Number: T1.2.7.1
database_cross_reference: CHV:0000035932
database_cross_reference: LCH_NW:sh85061768
database_cross_reference: MSH:D064591
database_cross_reference: MTH:U000914
database_cross_reference: NCI:C60701
database_cross_reference: RCD:X90J6
database_cross_reference: SNMI:G-D830
database_cross_reference: SNOMEDCT_US:123194006
database_cross_reference: SNOMEDCT_US:261221006
database_cross_reference: SNOMEDCT_US:7970006
database_cross_reference: UMD:17-165

Autografts
type: Class
subclass of: Transplants
PMOID: PMO:00000124
Subclass_of: Transplants
Synonym: Autochthonous graft
Synonym: Autochtonous graft
Synonym: Autogenous graft
Synonym: Autograft
Synonym: Autograft (substance)
Synonym: Autograft -RETIRED-
Synonym: Autograft Material
Synonym: Autologous Graft
Synonym: Autologous Transplant
Synonym: Autologous Transplants
Tree Number: T1.2.7.2
database_cross_reference: CHV:0000039572
database_cross_reference: CHV:0000045092
database_cross_reference: LCH_NW:sh85010065
database_cross_reference: MSH:D064592
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C75339
database_cross_reference: RCD:Xa4fP
database_cross_reference: SNMI:G-D810
database_cross_reference: SNOMEDCT_US:123146007
database_cross_reference: SNOMEDCT_US:15879007

Heterografts
type: Class
subclass of: Transplants
PMOID: PMO:00000125
Subclass_of: Transplants
Synonym: Heterograft
Synonym: Heterologous graft
Synonym: Heteroplastic graft
Synonym: Xenograft
Synonym: Xenograft (substance)
Synonym: Xenograft -RETIRED-
Synonym: Xenograft type of graft
Synonym: Xenografts
Synonym: Xenotransplant
Synonym: Xenotransplantation
Tree Number: T1.2.7.3
database_cross_reference: CHV:0000038160
database_cross_reference: LCH_NW:sh85148789
database_cross_reference: MSH:D064593
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12932
database_cross_reference: NCI:GTEx
database_cross_reference: NCI_NCI-GLOSS:CDR0000044095
database_cross_reference: RCD:X90Jk
database_cross_reference: SNMI:G-D840
database_cross_reference: SNOMEDCT_US:123147003
database_cross_reference: SNOMEDCT_US:67650000

Bone-Patellar Tendon-Bone Grafts
type: Class
subclass of: Transplants
PMOID: PMO:00000126
Subclass_of: Transplants
Synonym: Bone Patellar Tendon Bone Grafts
Synonym: Bone-Patellar Tendon-Bone Graft
Tree Number: T1.2.7.4
database_cross_reference: MSH:D064594

Composite Tissue Allografts
type: Class
subclass of: Transplants
PMOID: PMO:00000127
Subclass_of: Transplants
Synonym: Composite Tissue Allograft
Synonym: Vascularized Composite Allograft
Synonym: Vascularized Composite Allografts
Tree Number: T1.2.7.5
database_cross_reference: MSH:D064595

Isografts
type: Class
subclass of: Transplants
PMOID: PMO:00000128
Subclass_of: Transplants
Synonym: Homograft, Isogeneic
Synonym: Homograft, Syngeneic
Synonym: Homografts, Isogeneic
Synonym: Homografts, Syngeneic
Synonym: Isogeneic Homograft
Synonym: Isogeneic Homografts
Synonym: Isogeneic graft
Synonym: Isogeneic graft (substance)
Synonym: Isogeneic graft -RETIRED-
Synonym: Isograft
Tree Number: T1.2.7.6
database_cross_reference: CSP:2935-6726
database_cross_reference: MSH:D064596
database_cross_reference: MTH:U000298
database_cross_reference: NCI:C122939
database_cross_reference: RCD:XaDw8
database_cross_reference: SNMI:G-D820
database_cross_reference: SNOMEDCT_US:123195007
database_cross_reference: SNOMEDCT_US:67194007

Organs at Risk
type: Class
subclass of: Body Regions
PMOID: PMO:00000129
Subclass_of: Body Regions
Tree Number: T1.2.8

Anatomic Landmarks
type: Class
subclass of: Body Regions
PMOID: PMO:00000130
Subclass_of: Body Regions
Tree Number: T1.2.9

Transplant Donor Site
type: Class
subclass of: Body Regions
PMOID: PMO:00000131
Subclass_of: Body Regions
Tree Number: T1.2.10

Torso
type: Class
subclass of: Body Regions
PMOID: PMO:00000132
Subclass_of: Body Regions
Tree Number: T1.2.11

Abdomen
type: Class
subclass of: Torso
PMOID: PMO:00000133
Subclass_of: Torso
Synonym: ABDOMEN CANCER
Synonym: Abdomen--Cancer
Synonym: Malig neo abdomen
Synonym: Malignant neoplasm of abdomen
Synonym: Malignant neoplasm of abdomen (disorder)
Synonym: Malignant tumor of abdomen
Synonym: Malignant tumor of abdomen (disorder)
Synonym: Malignant tumour of abdomen
Synonym: abdomen cancer
Synonym: abdomen neoplasm
Tree Number: T1.2.11.1
database_cross_reference: CCPSS:0034377
database_cross_reference: CHV:0000017367
database_cross_reference: CSP:2005-4146
database_cross_reference: DO:DOID:122
database_cross_reference: DO:DOID:284
database_cross_reference: ICD10:C76.2
database_cross_reference: ICD10AM:C76.2
database_cross_reference: ICD10CM:C76.2
database_cross_reference: ICD9CM:195.2
database_cross_reference: LCH_NW:sh85000095
database_cross_reference: MDR:10025692
database_cross_reference: MEDCIN:98324
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:B552.
database_cross_reference: RCDAE:B552.
database_cross_reference: SNOMEDCT_US:188366002

Groin
type: Class
subclass of: Abdomen
PMOID: PMO:00000134
Subclass_of: Abdomen
Tree Number: T1.2.11.1.1

Inguinal Canal
type: Class
subclass of: Abdomen
PMOID: PMO:00000135
Subclass_of: Abdomen
Synonym: Entire inguinal canal
Synonym: Entire inguinal canal (body structure)
Synonym: Inguinal canal
Tree Number: T1.2.11.1.2
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:243966008

Umbilicus
type: Class
subclass of: Abdomen
PMOID: PMO:00000136
Subclass_of: Abdomen
Synonym: Entire umbilicus
Synonym: Entire umbilicus (body structure)
Tree Number: T1.2.11.1.3
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:265800007

Abdominal Cavity
type: Class
subclass of: Abdomen
PMOID: PMO:00000137
Subclass_of: Abdomen
Tree Number: T1.2.11.1.4

Peritoneum
type: Class
subclass of: Serous Membrane
PMOID: PMO:00000138
Subclass_of: Serous Membrane
Synonym: D44-D46 PERITONEUM
Synonym: PERITONEUM
Synonym: Peritoneum (serous membrane) structure
Synonym: Peritoneum (serous membrane) structure (body structure)
Synonym: Peritoneum, NOS
Synonym: Serous membrane of abdomen
Synonym: Serous membrane of abdomen, NOS
Synonym: Wall of peritoneal sac
Synonym: peritoneum
Tree Number: T1.3.8.4.2
database_cross_reference: AOD:0000016978
database_cross_reference: CHV:0000009529
database_cross_reference: CSP:0461-6710
database_cross_reference: FMA:9584
database_cross_reference: LCH:U003570
database_cross_reference: LCH_NW:sh85099958
database_cross_reference: LNC:LA4689-1
database_cross_reference: LNC:LP30178-5
database_cross_reference: LNC:MTHU014433
database_cross_reference: MSH:D010537
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12770
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12770
database_cross_reference: NCI_NCI-GLOSS:CDR0000045829
database_cross_reference: NCI_NICHD:C12770
database_cross_reference: RCD:7N812
database_cross_reference: SNM:T-Y4400
database_cross_reference: SNMI:T-D4400
database_cross_reference: SNOMEDCT_US:15425007
database_cross_reference: UWDA:9584

Peritoneal Stomata
type: Class
subclass of: Tissues
PMOID: PMO:00000144
Subclass_of: Tissues
Tree Number: T1.3.13

Abdominal Wall
type: Class
subclass of: Abdomen
PMOID: PMO:00000146
Subclass_of: Abdomen
Synonym: ABDOMINAL WALL
Synonym: AW - Abdominal wall
Synonym: Abdomen>Abdominal wall
Synonym: Abdominal wall
Synonym: Abdominal wall proper
Synonym: Abdominal wall structure
Synonym: Abdominal wall structure (body structure)
Synonym: Abdominal wall, NOS
Synonym: Wall of abdomen
Synonym: Wall of abdomen proper
Tree Number: T1.2.11.1.5
database_cross_reference: AOD:0000027656
database_cross_reference: CHV:0000049454
database_cross_reference: FMA:10429
database_cross_reference: FMA:299989
database_cross_reference: LCH:U000004
database_cross_reference: LCH_NW:sh85000113
database_cross_reference: LNC:LP208113-3
database_cross_reference: LNC:LP208114-1
database_cross_reference: LNC:LP6993-2
database_cross_reference: LNC:MTHU003020
database_cross_reference: LNC:MTHU052056
database_cross_reference: MSH:D034861
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C77608
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C77608
database_cross_reference: NCI_NICHD:C77608
database_cross_reference: PSY:00020
database_cross_reference: RCD:7N81.
database_cross_reference: RCD:Xa1SY
database_cross_reference: SNM:T-Y4300
database_cross_reference: SNMI:T-D4300
database_cross_reference: SNOMEDCT_US:83908009
database_cross_reference: UWDA:10429

Back
type: Class
subclass of: Torso
PMOID: PMO:00000147
Subclass_of: Torso
Tree Number: T1.2.11.2

Lumbosacral Region
type: Class
subclass of: Back
PMOID: PMO:00000148
Subclass_of: Back
Tree Number: T1.2.11.2.1

Sacrococcygeal Region
type: Class
subclass of: Back
PMOID: PMO:00000149
Subclass_of: Back
Tree Number: T1.2.11.2.2

Pelvis
type: Class
subclass of: Torso
PMOID: PMO:00000150
Subclass_of: Torso
Synonym: BODY CAVITY, PELVIC
Synonym: D6 PELVIS
Synonym: PELVIC
Synonym: PELVIS
Synonym: Pelvic
Synonym: Pelvic (qualifier value)
Synonym: Pelvic Cavity
Synonym: Pelvic Region
Synonym: Pelvic region
Synonym: Pelvic structure
Tree Number: T1.2.11.3
database_cross_reference: AOD:0000016996
database_cross_reference: CCPSS:0024053
database_cross_reference: CCPSS:1009911
database_cross_reference: CHV:0000009406
database_cross_reference: CSP:0468-6889
database_cross_reference: CST:BODY/PELV
database_cross_reference: LCH_NW:sh85099317
database_cross_reference: LNC:LA16744-7
database_cross_reference: LNC:LA4690-9
database_cross_reference: LNC:LP199998-8
database_cross_reference: LNC:LP7467-6
database_cross_reference: LNC:MTHU001438
database_cross_reference: MEDLINEPLUS:287
database_cross_reference: MSH:D010388
database_cross_reference: MTH:U002149
database_cross_reference: NCI:C12767
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12767
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NCI-GLOSS:CDR0000045087
database_cross_reference: NCI_NCI-GLOSS:CDR0000046246
database_cross_reference: NCI_NICHD:C12767
database_cross_reference: OMIM:MTHU000037
database_cross_reference: RCD:Ub1cR
database_cross_reference: RCD:Xa0JM
database_cross_reference: RCD:Xa1gg
database_cross_reference: SNM:T-Y6000
database_cross_reference: SNM:U000521
database_cross_reference: SNMI:T-D6000
database_cross_reference: SNOMEDCT_US:12921003
database_cross_reference: SNOMEDCT_US:277113001

Pelvic Floor
type: Class
subclass of: Pelvis
PMOID: PMO:00000151
Subclass_of: Pelvis
Synonym: Diaphragm, Pelvic
Synonym: Diaphragma pelvis
Synonym: Diaphragms, Pelvic
Synonym: Floor, Pelvic
Synonym: Muscle of pelvic diaphragm
Synonym: Pelvic Diaphragm
Synonym: Pelvic Diaphragms
Synonym: Pelvic diaphragm
Synonym: Pelvic floor
Synonym: Pelvic floor structure
Tree Number: T1.2.11.3.1
database_cross_reference: CHV:0000020880
database_cross_reference: CSP:0468-6889
database_cross_reference: FMA:19726
database_cross_reference: LCH_NW:sh95007753
database_cross_reference: MSH:D017773
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X74x4
database_cross_reference: RCD:Xa1vL
database_cross_reference: SNM:T-Y6261
database_cross_reference: SNMI:T-14303
database_cross_reference: SNMI:T-D6236
database_cross_reference: SNOMEDCT_US:12461007
database_cross_reference: SNOMEDCT_US:87770006
database_cross_reference: UWDA:19726
database_cross_reference: UWDA:24229

Lesser Pelvis
type: Class
subclass of: Pelvis
PMOID: PMO:00000152
Subclass_of: Pelvis
Synonym: Lesser pelvis
Synonym: Minor pelvis
Synonym: Minor pelvis structure
Synonym: Minor pelvis structure (body structure)
Synonym: Minor, Pelvis
Synonym: Pelvis Minor
Synonym: Pelvis vera
Synonym: Pelvis, Lesser
Synonym: Pelvis, True
Synonym: Small pelvis
Tree Number: T1.2.11.3.2
database_cross_reference: CHV:0000022510
database_cross_reference: MSH:D057892
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-11383
database_cross_reference: SNM:T-Y6220
database_cross_reference: SNMI:T-D6220
database_cross_reference: SNOMEDCT_US:80266002
database_cross_reference: UWDA:75420

Thorax
type: Class
subclass of: Torso
PMOID: PMO:00000153
Subclass_of: Torso
Synonym: Malig neop thorax NOS
Synonym: Malign neopl thorax
Synonym: Malignant Neoplasm of Thorax
Synonym: Malignant Neoplasm of the Thorax
Synonym: Malignant Thoracic Neoplasm
Synonym: Malignant Thoracic Tumor
Synonym: Malignant Tumor of Thorax
Synonym: Malignant Tumor of the Thorax
Synonym: Malignant neoplasm of thorax
Synonym: Malignant neoplasm of thorax (disorder)
Tree Number: T1.2.11.4
database_cross_reference: CHV:0000051572
database_cross_reference: CSP:2005-5041
database_cross_reference: ICD10:C76.1
database_cross_reference: ICD10AM:C76.1
database_cross_reference: ICD10CM:C76.1
database_cross_reference: ICD9CM:195.1
database_cross_reference: MDR:10026532
database_cross_reference: MEDCIN:98323
database_cross_reference: MTH:U000736
database_cross_reference: NCI:C3576
database_cross_reference: RCD:B551.
database_cross_reference: RCD:B551z
database_cross_reference: RCDAE:B551.
database_cross_reference: SNOMEDCT_US:188361007
database_cross_reference: SNOMEDCT_US:188365003

Thoracic Cavity
type: Class
subclass of: Thorax
PMOID: PMO:00000154
Subclass_of: Thorax
Tree Number: T1.2.11.4.1

Thoracic Wall
type: Class
subclass of: Thorax
PMOID: PMO:00000157
Subclass_of: Thorax
Synonym: CHEST WALL
Synonym: Chest Wall
Synonym: Chest wall
Synonym: Chest wall structure
Synonym: Chest wall structure (body structure)
Synonym: Chest wall, NOS
Synonym: THORACIC WALL
Synonym: Thoracic wall
Synonym: Wall of thorax
Synonym: Wall, Chest
Tree Number: T1.2.11.4.2
database_cross_reference: AOD:0000016971
database_cross_reference: CHV:0000020287
database_cross_reference: FMA:10428
database_cross_reference: FMA:50060
database_cross_reference: LNC:LA4178-5
database_cross_reference: LNC:LP208118-2
database_cross_reference: LNC:LP7140-9
database_cross_reference: LNC:MTHU002672
database_cross_reference: MSH:D035441
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C62484
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C62484
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NCI-GLOSS:CDR0000044996
database_cross_reference: NCI_NICHD:C62484
database_cross_reference: RCD:7N80.
database_cross_reference: RCD:Xa1SZ
database_cross_reference: SNM:T-Y2150
database_cross_reference: SNMI:T-D3050
database_cross_reference: SNOMEDCT_US:78904004
database_cross_reference: UWDA:10428
database_cross_reference: UWDA:50060

Trigger Points
type: Class
subclass of: Body Regions
PMOID: PMO:00000158
Subclass_of: Body Regions
Tree Number: T1.2.12

Tissues
type: Class
subclass of: Anatomical Structure
PMOID: PMO:00000159
Subclass_of: Anatomical Structure
Synonym: Body Tissues
Synonym: Body tissue
Synonym: Body tissue structure
Synonym: Body tissue structure (body structure)
Synonym: Body tissue, NOS
Synonym: Normal Tissue
Synonym: Portion of tissue
Synonym: TISSUE
Synonym: Textus
Synonym: Tiss
Tree Number: T1.3
database_cross_reference: AOD:0000001777
database_cross_reference: CCPSS:0019045
database_cross_reference: CHV:0000012321
database_cross_reference: CSP:2935-3962
database_cross_reference: FMA:9637
database_cross_reference: LCH:U006631
database_cross_reference: LCH_NW:sh85135594
database_cross_reference: LNC:LP200029-9
database_cross_reference: LNC:LP200064-6
database_cross_reference: LNC:LP61649-7
database_cross_reference: LNC:LP7641-6
database_cross_reference: LNC:MTHU049889
database_cross_reference: MSH:D014024
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12801
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12801
database_cross_reference: NCI_NCI-GLOSS:CDR0000046683
database_cross_reference: PSY:53300
database_cross_reference: SNM:T-00050
database_cross_reference: SNMI:T-D0050
database_cross_reference: SNOMEDCT_US:85756007
database_cross_reference: UWDA:9637

Parenchymal Tissue
type: Class
subclass of: Tissues
PMOID: PMO:00000160
Subclass_of: Tissues
Synonym: Parenchymal Tissues
Synonym: Tissue, Parenchymal
Synonym: Tissues, Parenchymal
Tree Number: T1.3.1
database_cross_reference: MSH:D000072356

Margins of Excision
type: Class
subclass of: Tissues
PMOID: PMO:00000161
Subclass_of: Tissues
Synonym: Excision Margin
Synonym: Excision Margins
Synonym: Margin, Resection
Synonym: Margin, Surgical
Synonym: Margins of Excision [Disease/Finding]
Synonym: Margins of excision
Synonym: Margins, Resection
Synonym: Margins, Surgical
Synonym: Resection Margin
Synonym: Resection Margins
Tree Number: T1.3.2
database_cross_reference: CHV:0000022434
database_cross_reference: MSH:D000072662
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C41227
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044531
database_cross_reference: NDFRT:N0000192881
database_cross_reference: SNM:T-00100
database_cross_reference: SNMI:T-D0100
database_cross_reference: SNOMEDCT_US:82868003

Body Fluid Compartments
type: Class
subclass of: Tissues
PMOID: PMO:00000162
Subclass_of: Tissues
Tree Number: T1.3.3

Extracellular Space
type: Class
subclass of: Body Fluid Compartments
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000163
Subclass_of: Body Fluid Compartments
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Tree Number: T1.3.3.1
Tree Number: T1.4.5
Tree Number: T2.8.5

Intracellular Space
type: Class
subclass of: Body Fluid Compartments
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000164
Subclass_of: Body Fluid Compartments
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Tree Number: T1.3.3.2
Tree Number: T1.4.8
Tree Number: T2.8.8

Connective Tissue
type: Class
subclass of: Tissues
PMOID: PMO:00000165
Subclass_of: Tissues
Synonym: CONNECTIVE TISSUE
Synonym: Connective Tissues
Synonym: Connective tissue
Synonym: Connective tissue (substance)
Synonym: Connective tissue structure
Synonym: Connective tissue structure (body structure)
Synonym: Connective tissue, NOS
Synonym: Connective tissues
Synonym: Portion of connective tissue
Synonym: Textus connectivus
Tree Number: T1.3.4
database_cross_reference: AOD:0000016845
database_cross_reference: CHV:0000003293
database_cross_reference: CSP:0729-5335
database_cross_reference: FMA:9640
database_cross_reference: LCH:U001138
database_cross_reference: LCH_NW:sh85031183
database_cross_reference: MSH:D003238
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12374
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12374
database_cross_reference: NCI_NCI-GLOSS:CDR0000044013
database_cross_reference: NCI_NICHD:C12374
database_cross_reference: PSY:11330
database_cross_reference: RCD:7N8A3
database_cross_reference: SNM:T-1X200
database_cross_reference: SNMI:T-1A200
database_cross_reference: SNOMEDCT_US:181769001
database_cross_reference: SNOMEDCT_US:21793004
database_cross_reference: UWDA:9640

Adipose Tissue
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000166
Subclass_of: Connective Tissue
Synonym: ADIPOSE TISSUE
Synonym: Adipocytus unigutturalis
Synonym: Adipose tissue
Synonym: Adipose tissue (body structure)
Synonym: Adipose tissues
Synonym: Body Fat
Synonym: Fat Tissue
Synonym: Fatty Tissue
Synonym: Fatty tissue
Synonym: Textus adiposus albus
Tree Number: T1.3.4.1
database_cross_reference: AOD:0000016854
database_cross_reference: AOD:0000027611
database_cross_reference: CHV:0000000740
database_cross_reference: CHV:0000021877
database_cross_reference: CSP:0729-5444
database_cross_reference: CSP:0729-5627
database_cross_reference: FMA:20110
database_cross_reference: LCH:U000075
database_cross_reference: LCH_NW:sh85000877
database_cross_reference: LNC:LP7226-6
database_cross_reference: MSH:D000273
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12472
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12472
database_cross_reference: NCI_CDISC:SDTM-SPECTYPE
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: RCD:XaBo1
database_cross_reference: SNM:T-1X010
database_cross_reference: SNM:T-1X020
database_cross_reference: SNMI:T-1A010
database_cross_reference: SNMI:T-1A020
database_cross_reference: SNOMEDCT_US:38888009
database_cross_reference: SNOMEDCT_US:55603005
database_cross_reference: UWDA:20110
database_cross_reference: UWDA:20117

Adipose Tissue, Beige
type: Class
subclass of: Adipose Tissue
PMOID: PMO:00000167
Subclass_of: Adipose Tissue
Synonym: Adipose Tissue, Brite
Synonym: Adipose Tissues, Beige
Synonym: Adipose Tissues, Brite
Synonym: Beige Adipose Tissue
Synonym: Beige Adipose Tissues
Synonym: Beige Brite Adipose Tissue
Synonym: Beige Brite Fat
Synonym: Beige Brite Fats
Synonym: Beige Fat
Synonym: Brite Adipose Tissue
Tree Number: T1.3.4.1.1
database_cross_reference: MSH:D000069796

Adipose Tissue, Brown
type: Class
subclass of: Adipose Tissue
PMOID: PMO:00000168
Subclass_of: Adipose Tissue
Synonym: ADIPOSE TISSUE, BROWN
Synonym: Adipocytus multigutturalis
Synonym: BAT
Synonym: Bat
Synonym: Brown Adipose Tissue
Synonym: Brown Fat
Synonym: Brown adipose tissue
Synonym: Brown fat
Synonym: Brown fat (body structure)
Synonym: Fat, Brown
Tree Number: T1.3.4.1.2
database_cross_reference: AOD:0000016856
database_cross_reference: CHV:0000002198
database_cross_reference: CSP:0729-5553
database_cross_reference: DRUGBANK:DB13897
database_cross_reference: DRUGBANK:DB13898
database_cross_reference: DRUGBANK:DB13899
database_cross_reference: DRUGBANK:DB13900
database_cross_reference: DRUGBANK:DB13901
database_cross_reference: DRUGBANK:DB13902
database_cross_reference: DRUGBANK:DB13903
database_cross_reference: FMA:20118
database_cross_reference: LCH_NW:sh85017245
database_cross_reference: MSH:D002001
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32235
database_cross_reference: NCI_CDISC:C32235
database_cross_reference: SNM:T-1X040
database_cross_reference: SNMI:T-1A040
database_cross_reference: SNOMEDCT_US:15965003
database_cross_reference: UWDA:20118

Adipose Tissue, White
type: Class
subclass of: Adipose Tissue
PMOID: PMO:00000169
Subclass_of: Adipose Tissue
Synonym: ADIPOSE TISSUE, WHITE
Synonym: Adipocytus unigutturalis
Synonym: Fat, White
Synonym: Textus adiposus albus
Synonym: Tissue, White Adipose
Synonym: Unilocular adipose tissue
Synonym: White Adipose Tissue
Synonym: White Fat
Synonym: White adipose tissue
Synonym: White fat
Tree Number: T1.3.4.1.3
database_cross_reference: CHV:0000021877
database_cross_reference: CSP:0729-5444
database_cross_reference: FMA:20117
database_cross_reference: MSH:D052436
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33889
database_cross_reference: NCI_CDISC:C33889
database_cross_reference: UWDA:20117

Bone and Bones
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000174
Subclass_of: Connective Tissue
Synonym: BONE BONES
Synonym: BONES BONE
Synonym: Bones and Bone
Synonym: Bones and Bone Tissue
Synonym: bone and bones
Synonym: bone bone
Tree Number: T1.3.4.2
database_cross_reference: CHV:0000002059
database_cross_reference: MSH:D001842

Bone-Implant Interface
type: Class
subclass of: Bone and Bones
PMOID: PMO:00000175
Subclass_of: Bone and Bones
Tree Number: T1.3.4.2.1

Cortical Bone
type: Class
subclass of: Bone and Bones
PMOID: PMO:00000176
Subclass_of: Bone and Bones
Synonym: Bone Cortex
Synonym: Compact Bone
Synonym: Compact Bone Tissue
Synonym: Compact Bones
Synonym: Compact bone
Synonym: Compact bone (tissue)
Synonym: Compact bone structure
Synonym: Compact bone structure (body structure)
Synonym: Compact bone tissue
Synonym: Cortex of Bone
Tree Number: T1.3.4.2.2
database_cross_reference: AOD:0000016873
database_cross_reference: AOD:0000027620
database_cross_reference: AOD:0000027623
database_cross_reference: AOD:0000027624
database_cross_reference: CHV:0000021607
database_cross_reference: FMA:24018
database_cross_reference: MSH:D000071538
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C52714
database_cross_reference: SNM:T-1X542
database_cross_reference: SNMI:T-11031
database_cross_reference: SNOMEDCT_US:32217005
database_cross_reference: UWDA:24018
database_cross_reference: UWDA:66766

Cancellous Bone
type: Class
subclass of: Bone and Bones
PMOID: PMO:00000178
Subclass_of: Bone and Bones
Synonym: Bone, Cancellous
Synonym: Bone, Spongy
Synonym: Bone, Trabecular
Synonym: Bones, Cancellous
Synonym: Bones, Spongy
Synonym: Bones, Trabecular
Synonym: Cancellous Bones
Synonym: Cancellous bone
Synonym: Cancellous bone (substance)
Synonym: Spongy Bone
Tree Number: T1.3.4.2.3
database_cross_reference: AOD:0000016875
database_cross_reference: AOD:0000027626
database_cross_reference: AOD:0000027628
database_cross_reference: AOD:0000027630
database_cross_reference: AOD:0000027632
database_cross_reference: CHV:0000021606
database_cross_reference: CSP:4007-0118
database_cross_reference: FMA:24019
database_cross_reference: FMA:85273
database_cross_reference: MSH:D000071556
database_cross_reference: RCD:X90Dy
database_cross_reference: SNM:T-1X540
database_cross_reference: SNM:T-1X541
database_cross_reference: SNMI:T-11030
database_cross_reference: SNOMEDCT_US:20870005
database_cross_reference: SNOMEDCT_US:261229008
database_cross_reference: UWDA:24019
database_cross_reference: UWDA:66767

Bone Matrix
type: Class
subclass of: Bone and Bones
PMOID: PMO:00000179
Subclass_of: Bone and Bones
Synonym: Bone Matrices
Synonym: Bone matrix
Synonym: Bone matrix (substance)
Synonym: Matrices, Bone
Synonym: Matrix, Bone
Synonym: bone matrix
Tree Number: T1.3.4.2.4
database_cross_reference: AOD:0000016878
database_cross_reference: CHV:0000002078
database_cross_reference: FMA:66830
database_cross_reference: MSH:D001857
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32222
database_cross_reference: SNMI:T-11034
database_cross_reference: SNOMEDCT_US:45001002

Bony Callus
type: Class
subclass of: Bone and Bones
PMOID: PMO:00000180
Subclass_of: Bone and Bones
Synonym: Bone callus
Synonym: Bony callus
Synonym: Bony callus (morphologic abnormality)
Synonym: CALLUS
Synonym: Callus
Synonym: Callus of bone
Synonym: Callus of bone (finding)
Synonym: Callus, Bony
Synonym: bone callus
Synonym: bony callus
Tree Number: T1.3.4.2.5
database_cross_reference: CHV:0000002318
database_cross_reference: COSTAR:132
database_cross_reference: MSH:D002146
database_cross_reference: MTH:U001777
database_cross_reference: SNM:M-49920
database_cross_reference: SNMI:M-78870
database_cross_reference: SNOMEDCT_US:27881006
database_cross_reference: SNOMEDCT_US:443092002

Periosteum
type: Class
subclass of: Bone and Bones
PMOID: PMO:00000181
Subclass_of: Bone and Bones
Synonym: Periosteum (body structure)
Synonym: periosteum
Tree Number: T1.3.4.2.6
database_cross_reference: AOD:0000016889
database_cross_reference: CHV:0000009513
database_cross_reference: CSP:2715-3800
database_cross_reference: FMA:24041
database_cross_reference: LCH:U003564
database_cross_reference: LCH_NW:sh85099929
database_cross_reference: MSH:D010521
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13184
database_cross_reference: SNM:T-1X510
database_cross_reference: SNMI:T-11020
database_cross_reference: SNOMEDCT_US:33840008
database_cross_reference: UWDA:24041

Cartilage
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000182
Subclass_of: Connective Tissue
Synonym: 1A7 CARTILAGINOUS TISSUES
Synonym: CARTILAGE
Synonym: CARTILAGINOUS TISSUES
Synonym: Cartilage (tissue)
Synonym: Cartilage tissue
Synonym: Cartilage tissue (body structure)
Synonym: Cartilage, NOS
Synonym: Cartilagenous
Synonym: Cartilages
Synonym: Cartilages set
Tree Number: T1.3.4.3
database_cross_reference: AOD:0000016859
database_cross_reference: CHV:0000002496
database_cross_reference: CHV:0000057131
database_cross_reference: CSP:2715-4273
database_cross_reference: FMA:37377
database_cross_reference: FMA:71500
database_cross_reference: LCH:U000824
database_cross_reference: LCH_NW:sh85020509
database_cross_reference: MSH:D002356
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12373
database_cross_reference: NCI:C32268
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C32268
database_cross_reference: NCI_NCI-GLOSS:CDR0000044190
database_cross_reference: NDDF:005578
database_cross_reference: RCD:X79Xk
database_cross_reference: SNM:T-1X700
database_cross_reference: SNM:U000425
database_cross_reference: SNMI:T-1A700
database_cross_reference: SNOMEDCT_US:309312004
database_cross_reference: SNOMEDCT_US:61496007
database_cross_reference: UWDA:37377
database_cross_reference: UWDA:71500

Fibrocartilage
type: Class
subclass of: Cartilage
PMOID: PMO:00000183
Subclass_of: Cartilage
Synonym: Fibrocartilage (body structure)
Synonym: Fibrocartilage, NOS
Synonym: fibrocartilage
Synonym: fibrous cartilage
Tree Number: T1.3.4.3.1
database_cross_reference: AOD:0000016867
database_cross_reference: AOD:0000027614
database_cross_reference: CHV:0000043931
database_cross_reference: FMA:64784
database_cross_reference: MSH:D051445
database_cross_reference: NCI:C32599
database_cross_reference: SNMI:T-1A715
database_cross_reference: SNOMEDCT_US:91685003
database_cross_reference: UWDA:64784

Hyaline Cartilage
type: Class
subclass of: Cartilage
PMOID: PMO:00000192
Subclass_of: Cartilage
Synonym: Cartilage, Hyaline
Synonym: Cartilages, Hyaline
Synonym: Hyaline Cartilages
Synonym: Hyaline cartilage
Synonym: Hyaline cartilage (body structure)
Synonym: hyaline cartilage
Tree Number: T1.3.4.3.2
database_cross_reference: AOD:0000016861
database_cross_reference: CHV:0000021901
database_cross_reference: FMA:64783
database_cross_reference: MSH:D051457
database_cross_reference: NCI:C32746
database_cross_reference: SNM:T-1X710
database_cross_reference: SNMI:T-1A710
database_cross_reference: SNOMEDCT_US:39298000
database_cross_reference: UWDA:64783

Elastic Cartilage
type: Class
subclass of: Cartilage
PMOID: PMO:00000193
Subclass_of: Cartilage
Synonym: Cartilage, Elastic
Synonym: Cartilages, Elastic
Synonym: Elastic Cartilages
Synonym: Elastic cartilage
Synonym: elastic cartilage
Synonym: reticular cartilage
Synonym: yellow cartilage
Tree Number: T1.3.4.3.3
database_cross_reference: AOD:0000016868
database_cross_reference: AOD:0000027615
database_cross_reference: AOD:0000027616
database_cross_reference: CHV:0000043640
database_cross_reference: FMA:64785
database_cross_reference: MSH:D051472
database_cross_reference: NCI:C32494
database_cross_reference: UWDA:64785

Elastic Tissue
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000194
Subclass_of: Connective Tissue
Synonym: Elastic Tissues
Synonym: Elastic connective tissue
Synonym: Elastic tissue
Synonym: Elastic tissue (body structure)
Synonym: Elastic tissue, NOS
Synonym: Textus connectivus elasticus
Synonym: Tissue, Elastic
Synonym: Tissues, Elastic
Synonym: elastic tissue
Tree Number: T1.3.4.4
database_cross_reference: CHV:0000004312
database_cross_reference: CSP:0729-5662
database_cross_reference: FMA:20113
database_cross_reference: LCH:U001517
database_cross_reference: LCH_NW:sh85041513
database_cross_reference: MSH:D004547
database_cross_reference: SNM:T-1X240
database_cross_reference: SNMI:T-1A240
database_cross_reference: SNOMEDCT_US:27197004
database_cross_reference: UWDA:20113

Fascia
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000195
Subclass_of: Connective Tissue
Synonym: 186-189 FASCIAS/APONEUROSES
Synonym: FASCIA
Synonym: FASCIAS/APONEUROSES
Synonym: Fascia (body structure)
Synonym: Fascia (cluster)
Synonym: Fascia (organ)
Synonym: Fascia cluster
Synonym: Fascia organ
Synonym: Fascia organ component
Synonym: Fascia, NOS
Tree Number: T1.3.4.5
database_cross_reference: AOD:0000016919
database_cross_reference: CHV:0000004898
database_cross_reference: CSP:0729-5335
database_cross_reference: FMA:20185
database_cross_reference: FMA:30318
database_cross_reference: FMA:321912
database_cross_reference: FMA:5023
database_cross_reference: MSH:D005205
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13108
database_cross_reference: NCI_CDISC:C13108
database_cross_reference: NCI_NICHD:C13108
database_cross_reference: RCD:7N8B.
database_cross_reference: RCD:X909X
database_cross_reference: RCD:XaAqD
database_cross_reference: SNM:T-18600
database_cross_reference: SNM:U000422
database_cross_reference: SNMI:T-18600
database_cross_reference: SNOMEDCT_US:181766008
database_cross_reference: SNOMEDCT_US:261078007
database_cross_reference: SNOMEDCT_US:84820005
database_cross_reference: UWDA:20185
database_cross_reference: UWDA:30318
database_cross_reference: UWDA:5023

Fascia Lata
type: Class
subclass of: Fascia
PMOID: PMO:00000196
Subclass_of: Fascia
Synonym: Fascia Latas
Synonym: Fascia lata
Synonym: Fascia lata structure
Synonym: Fascia lata structure (body structure)
Synonym: Lata, Fascia
Synonym: Latas, Fascia
Synonym: fascia lata
Tree Number: T1.3.4.5.1
database_cross_reference: CHV:0000004899
database_cross_reference: FMA:13902
database_cross_reference: MSH:D005206
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32585
database_cross_reference: SNM:T-18910
database_cross_reference: SNMI:T-18910
database_cross_reference: SNOMEDCT_US:85695001
database_cross_reference: UWDA:13902

Tenon Capsule
type: Class
subclass of: Fascia
PMOID: PMO:00000197
Subclass_of: Fascia
Synonym: Capsule of Tenon
Synonym: Capsule, Tenon
Synonym: Capsule, Tenon's
Synonym: Eyeball, sheath
Synonym: Fascia bulbi
Synonym: Fascial sheath of eyeball
Synonym: Sheath of eyeball
Synonym: Structure of fascial sheath of eyeball
Synonym: Structure of fascial sheath of eyeball (body structure)
Synonym: Substantia Propria
Tree Number: T1.3.4.5.2
database_cross_reference: CHV:0000036863
database_cross_reference: FMA:58734
database_cross_reference: MSH:D058475
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33652
database_cross_reference: RCD:Xa1ST
database_cross_reference: RCD:Xa1TF
database_cross_reference: SNM:T-XX009
database_cross_reference: SNM:T-XX801
database_cross_reference: SNMI:T-AA009
database_cross_reference: SNOMEDCT_US:77011004

Granulation Tissue
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000198
Subclass_of: Connective Tissue
Synonym: Granulation Tissues
Synonym: Granulation of tissue
Synonym: Granulation of tissue (finding)
Synonym: Granulation tissue
Synonym: Granulation tissue (morphologic abnormality)
Synonym: Granulation tissue, NOS
Synonym: Tissue granulation
Synonym: Tissue, Granulation
Synonym: Tissues, Granulation
Synonym: granulation of tissue
Tree Number: T1.3.4.6
database_cross_reference: AOD:0000001778
database_cross_reference: CHV:0000005682
database_cross_reference: CHV:0000044130
database_cross_reference: LCH:U002034
database_cross_reference: LCH_NW:sh85056439
database_cross_reference: MDR:10018675
database_cross_reference: MSH:D006097
database_cross_reference: NCI:C34652
database_cross_reference: RCD:Ua1bK
database_cross_reference: SNM:M-45020
database_cross_reference: SNMI:M-45020
database_cross_reference: SNOMEDCT_US:225541009
database_cross_reference: SNOMEDCT_US:61363009

Cicatrix
type: Class
subclass of: Granulation Tissue
PMOID: PMO:00000199
Subclass_of: Granulation Tissue
Synonym: Cicatrices
Synonym: Cicatrix [Disease/Finding]
Synonym: Fibrous scar
Synonym: Healing scar
Synonym: Healing scar (morphologic abnormality)
Synonym: SCAR
Synonym: Scar
Synonym: Scar (disorder)
Synonym: Scar (morphologic abnormality)
Synonym: Scar NOS
Tree Number: T1.3.4.6.1
database_cross_reference: CCPSS:0037723
database_cross_reference: COSTAR:U000604
database_cross_reference: CSP:1583-6215
database_cross_reference: ICD10CM:L90.5
database_cross_reference: ICPC2P:S99020
database_cross_reference: LCH:U001021
database_cross_reference: LCH_NW:sh85025918
database_cross_reference: LNC:LA24887-4
database_cross_reference: MDR:10039580
database_cross_reference: MDR:10039589
database_cross_reference: MEDCIN:34402
database_cross_reference: MEDCIN:6138
database_cross_reference: MEDLINEPLUS:3195
database_cross_reference: MSH:D002921
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHICD9:709.2
database_cross_reference: NCI:C34483
database_cross_reference: NCI_CDISC:C34483
database_cross_reference: NCI_FDA:2061
database_cross_reference: NCI_NICHD:C34483
database_cross_reference: NDFRT:N0000000790
database_cross_reference: OMIM:MTHU010020
database_cross_reference: RCD:XE1BX
database_cross_reference: RCD:XM1NO
database_cross_reference: SNM:M-49060
database_cross_reference: SNMI:M-78060
database_cross_reference: SNOMEDCT_US:123121007
database_cross_reference: SNOMEDCT_US:12402003
database_cross_reference: SNOMEDCT_US:156442008
database_cross_reference: SNOMEDCT_US:156443003
database_cross_reference: SNOMEDCT_US:201312003
database_cross_reference: SNOMEDCT_US:255450007
database_cross_reference: SNOMEDCT_US:267822001
database_cross_reference: SNOMEDCT_US:267872004
database_cross_reference: SNOMEDCT_US:275322007
database_cross_reference: SNOMEDCT_US:48677004

Ligaments
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000203
Subclass_of: Connective Tissue
Synonym: 180-185 LIGAMENTS
Synonym: LIGAMENT
Synonym: LIGAMENTS
Synonym: Ligament
Synonym: Ligament (body structure)
Synonym: Ligament, NOS
Synonym: Ligamenta
Synonym: Ligaments set
Synonym: Set of ligaments
Synonym: Structure of ligament
Tree Number: T1.3.4.7
database_cross_reference: CHV:0000007416
database_cross_reference: CSP:2715-5176
database_cross_reference: FMA:30319
database_cross_reference: FMA:70773
database_cross_reference: LCH:U002692
database_cross_reference: LCH_NW:sh85076865
database_cross_reference: MSH:D008022
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13046
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13046
database_cross_reference: NCI_NICHD:C13046
database_cross_reference: SNM:T-18010
database_cross_reference: SNM:U000421
database_cross_reference: SNMI:T-18000
database_cross_reference: SNMI:T-18010
database_cross_reference: SNOMEDCT_US:256660002
database_cross_reference: SNOMEDCT_US:52082005
database_cross_reference: UWDA:30319
database_cross_reference: UWDA:70773

Round Ligaments
type: Class
subclass of: Ligaments
PMOID: PMO:00000204
Subclass_of: Ligaments
Synonym: Hunter's ligament
Synonym: Ligamentum Teres Uteri
Synonym: Ligamentum Teres Uterus
Synonym: Ligamentum teres uteri
Synonym: Round Ligament of Uterus
Synonym: Round Ligament of the Uterus
Synonym: Round ligament
Synonym: Round ligament of uterus
Synonym: Structure of round ligament of uterus
Synonym: Structure of round ligament of uterus (body structure)
Tree Number: T1.3.4.7.1
database_cross_reference: CHV:0000010955
database_cross_reference: FMA:20420
database_cross_reference: MSH:D012404
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34009
database_cross_reference: RCD:X756q
database_cross_reference: SNM:T-86700
database_cross_reference: SNMI:T-D6507
database_cross_reference: SNOMEDCT_US:50840003
database_cross_reference: UWDA:20420

Broad Ligament
type: Class
subclass of: Ligaments
PMOID: PMO:00000208
Subclass_of: Ligaments
Synonym: Broad Ligaments
Synonym: Broad ligament
Synonym: Broad ligament of uterus
Synonym: Broad ligament structure
Synonym: Broad ligament structure (body structure)
Synonym: Broad ligament, NOS
Synonym: Broad uterine ligament
Synonym: Lateral Ligament
Synonym: Ligament, Broad
Synonym: Ligaments, Broad
Tree Number: T1.3.4.7.2
database_cross_reference: CHV:0000002166
database_cross_reference: FMA:16516
database_cross_reference: MSH:D001956
database_cross_reference: MTH:U001765
database_cross_reference: NCI:C12318
database_cross_reference: NCI:TCGA
database_cross_reference: SNM:T-86300
database_cross_reference: SNMI:T-D6500
database_cross_reference: SNOMEDCT_US:34411009
database_cross_reference: UWDA:16516

Ligaments, Articular
type: Class
subclass of: Ligaments
PMOID: PMO:00000209
Subclass_of: Ligaments
Synonym: Articular Ligament
Synonym: Articular Ligaments
Synonym: Articular ligaments
Synonym: Ligament
Synonym: Ligament of joint
Synonym: Ligament of joint (body structure)
Synonym: Ligament of joint, unspec
Synonym: Ligament of joint, unspecified
Synonym: Ligament of joint, unspecified (body structure)
Synonym: Ligament, Articular
Tree Number: T1.3.4.7.3
database_cross_reference: AOD:0000017066
database_cross_reference: CHV:0000007417
database_cross_reference: CSP:2715-5219
database_cross_reference: MSH:D008023
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:7NAK1
database_cross_reference: RCD:7NC..
database_cross_reference: RCDSY:7NAK1
database_cross_reference: RCDSY:7NC..
database_cross_reference: SNOMEDCT_US:123859001
database_cross_reference: SNOMEDCT_US:182237007

Subcutaneous Tissue
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000219
Subclass_of: Connective Tissue
Synonym: Adipose Tissue, Subcutaneous
Synonym: Fat, Subcutaneous
Synonym: Fats, Subcutaneous
Synonym: Fatty layer of subcutaneous tissue
Synonym: Fatty layer of superficial fascia
Synonym: Paniculus adiposus
Synonym: Panniculus adiposus
Synonym: Panniculus adiposus (Tela subcutanea)
Synonym: Panniculus adiposus telae subcutaneae
Synonym: SUBCUTIS
Tree Number: T1.3.4.8
database_cross_reference: CHV:0000021586
database_cross_reference: FMA:74315
database_cross_reference: MSH:D050151
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33645
database_cross_reference: NCI_CDISC:C33645
database_cross_reference: NCI_NICHD:C33645
database_cross_reference: SNM:T-1X030
database_cross_reference: SNMI:T-03020
database_cross_reference: SNOMEDCT_US:67769002
database_cross_reference: UWDA:74315
database_cross_reference: UWDA:78251

Wharton Jelly
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000220
Subclass_of: Connective Tissue
Synonym: Jelly, Wharton
Synonym: Jelly, Wharton's
Synonym: Structure of Wharton jelly
Synonym: Structure of Wharton's jelly
Synonym: Structure of Wharton's jelly (body structure)
Synonym: Umbilical mucous connective tissue
Synonym: Wharton's Jelly
Synonym: Wharton's jelly
Synonym: Whartons Jelly
Synonym: wharton's jelly
Tree Number: T1.3.4.9
database_cross_reference: CHV:0000022584
database_cross_reference: MSH:D059631
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34213
database_cross_reference: SNM:T-88830
database_cross_reference: SNMI:T-F1830
database_cross_reference: SNOMEDCT_US:53455001

Adventitia
type: Class
subclass of: Connective Tissue
PMOID: PMO:00000221
Subclass_of: Connective Tissue
Synonym: Adventitia, Tunica
Synonym: Tunica Adventitia
Synonym: Tunica Externa
Synonym: Tunica adventitia
Synonym: Tunica adventitia (body structure)
Synonym: Tunica adventitia, NOS
Synonym: Tunica externa
Synonym: adventitia
Synonym: tunica adventitia
Tree Number: T1.3.4.10
database_cross_reference: AOD:0000016914
database_cross_reference: AOD:0000027647
database_cross_reference: CHV:0000021891
database_cross_reference: FMA:45635
database_cross_reference: MSH:D063194
database_cross_reference: NCI:C33818
database_cross_reference: SNMI:T-1A190
database_cross_reference: SNOMEDCT_US:30180000
database_cross_reference: UWDA:45635
database_cross_reference: UWDA:76726

Epithelium
type: Class
subclass of: Tissues
PMOID: PMO:00000222
Subclass_of: Tissues
Synonym: Epithelial Tissue
Synonym: Epithelial Tissues
Synonym: Epithelial tissue
Synonym: Epithelial tissue, NOS
Synonym: Epithelium (body structure)
Synonym: Epithelium, NOS
Synonym: Portion of epithelium
Synonym: Textus epithelialis
Synonym: Tissue, Epithelial
Synonym: Tissues, Epithelial
Tree Number: T1.3.5
database_cross_reference: AOD:0000016922
database_cross_reference: AOD:0000027649
database_cross_reference: CHV:0000004580
database_cross_reference: CSP:2935-4235
database_cross_reference: FMA:9639
database_cross_reference: LCH:U001633
database_cross_reference: LCH_NW:sh85044466
database_cross_reference: LNC:LP34857-0
database_cross_reference: MSH:D004848
database_cross_reference: NCI:C12710
database_cross_reference: NCI:C45714
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046423
database_cross_reference: PSY:17730
database_cross_reference: SNM:T-00250
database_cross_reference: SNMI:T-00250
database_cross_reference: SNOMEDCT_US:31610004
database_cross_reference: UWDA:9639

Basement Membrane
type: Class
subclass of: Epithelium
subclass of: Membranes
PMOID: PMO:00000223
Subclass_of: Epithelium
Subclass_of: Membranes
Synonym: Basement Membranes
Synonym: Basement membrane
Synonym: Basement membrane (body structure)
Synonym: Basement membrane of connective tissue
Synonym: Basement membrane, NOS
Synonym: Membrana basalis
Synonym: Membrane, Basement
Synonym: Membranes, Basement
Synonym: basement membrane
Synonym: basement membranes
Tree Number: T1.3.5.1
Tree Number: T1.3.8.1
database_cross_reference: CHV:0000001722
database_cross_reference: CSP:1831-6535
database_cross_reference: FMA:63872
database_cross_reference: GO:GO:0005604
database_cross_reference: LCH_NW:sh85083467
database_cross_reference: LNC:LP14903-6
database_cross_reference: MSH:D001485
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13191
database_cross_reference: SNM:T-01210
database_cross_reference: SNMI:T-1A160
database_cross_reference: SNOMEDCT_US:123226008
database_cross_reference: SNOMEDCT_US:68989006
database_cross_reference: UWDA:63872

Bruch Membrane
type: Class
subclass of: Basement Membrane
PMOID: PMO:00000224
Subclass_of: Basement Membrane
Synonym: Basal lamina of choroid
Synonym: Bruch's Membrane
Synonym: Bruch's basal membrane
Synonym: Bruch's membrane
Synonym: Bruchs Membrane
Synonym: Lamina Basalis Choroideae
Synonym: Lamina basalis (Choroid)
Synonym: Lamina choroideae basalis
Synonym: Membrane, Bruch
Synonym: Membrane, Bruch's
Tree Number: T1.3.5.1.1
Tree Number: T1.3.8.1.3
database_cross_reference: FMA:58438
database_cross_reference: MSH:D016570
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-XX350
database_cross_reference: SNMI:T-AA350
database_cross_reference: SNOMEDCT_US:23127007
database_cross_reference: UWDA:58438

Endothelium
type: Class
subclass of: Epithelium
PMOID: PMO:00000225
Subclass_of: Epithelium
Synonym: Endothelial
Synonym: Endothelial tissue
Synonym: Endothelial tissue, NOS
Synonym: Endothelium (body structure)
Synonym: Endothelium, NOS
Synonym: Endotheliums
Synonym: endothelial tissue
Synonym: endothelium
Tree Number: T1.3.5.2
database_cross_reference: AOD:0000016935
database_cross_reference: CHV:0000004476
database_cross_reference: FMA:63916
database_cross_reference: LCH:U001591
database_cross_reference: LCH_NW:sh85043102
database_cross_reference: MSH:D004727
database_cross_reference: NCI:C12481
database_cross_reference: NCI:TCGA
database_cross_reference: SNM:T-1X160
database_cross_reference: SNMI:T-1A130
database_cross_reference: SNOMEDCT_US:27168002
database_cross_reference: UWDA:63916

Endothelium, Corneal
type: Class
subclass of: Endothelium
PMOID: PMO:00000226
Subclass_of: Endothelium
Synonym: Corneal Endothelium
Synonym: Corneal endothelium
Synonym: Endothelium of cornea
Synonym: Structure of corneal endothelium
Synonym: Structure of corneal endothelium (body structure)
Synonym: corneal endothelium
Tree Number: T1.3.5.2.1
database_cross_reference: CHV:0000004477
database_cross_reference: CSP:1109-4715
database_cross_reference: FMA:312267
database_cross_reference: MSH:D004728
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12707
database_cross_reference: SNOMEDCT_US:65431007
database_cross_reference: UWDA:63882

Endothelium, Lymphatic
type: Class
subclass of: Endothelium
PMOID: PMO:00000227
Subclass_of: Endothelium
Synonym: Endotheliums, Lymphatic
Synonym: Lymphatic Endothelium
Synonym: Lymphatic Endotheliums
Tree Number: T1.3.5.2.2
database_cross_reference: MSH:D004729

Endothelium, Vascular
type: Class
subclass of: Endothelium
PMOID: PMO:00000228
Subclass_of: Endothelium
Synonym: Endotheliums, Vascular
Synonym: Vascular Endothelium
Synonym: Vascular Endotheliums
Synonym: Vascular endothelium
Synonym: vascular endothelium
Tree Number: T1.3.5.2.3
database_cross_reference: CSP:0581-5523
database_cross_reference: LCH_NW:sh88005427
database_cross_reference: MSH:D004730
database_cross_reference: NCI:C13053

Epidermis
type: Class
subclass of: Epithelium
PMOID: PMO:00000229
Subclass_of: Epithelium
Synonym: EPIDERMAL TISSUE
Synonym: Entire portion of epidermis
Synonym: Epidermal
Synonym: Epidermis structure
Synonym: Epidermis structure (body structure)
Synonym: epidermis
Tree Number: T1.3.5.3
database_cross_reference: AOD:0000017124
database_cross_reference: CHV:0000004546
database_cross_reference: CSP:2716-0373
database_cross_reference: FMA:70596
database_cross_reference: LCH:U001626
database_cross_reference: LCH_NW:sh85044375
database_cross_reference: LNC:LP14303-9
database_cross_reference: MSH:D004817
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12708
database_cross_reference: NCI_CDISC:C12708
database_cross_reference: NCI_NCI-GLOSS:CDR0000046418
database_cross_reference: SNM:T-01100
database_cross_reference: SNMI:T-01100
database_cross_reference: SNOMEDCT_US:55988001
database_cross_reference: UWDA:70596

Hair Follicle
type: Class
subclass of: Epidermis
PMOID: PMO:00000230
Subclass_of: Epidermis
Synonym: Follicle, Hair
Synonym: Follicles
Synonym: Follicles, Hair
Synonym: Folliculus pili
Synonym: HAIR FOLLICLE
Synonym: Hair Follicles
Synonym: Hair follicle
Synonym: Hair follicle structure
Synonym: Hair follicle structure (body structure)
Synonym: Hair follicles
Tree Number: T1.3.5.3.1
database_cross_reference: AOD:0000017163
database_cross_reference: CHV:0000021522
database_cross_reference: CSP:2716-0997
database_cross_reference: FMA:70660
database_cross_reference: LCH_NW:sh85058320
database_cross_reference: MSH:D018859
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13317
database_cross_reference: NCI_CDISC:C13317
database_cross_reference: NCI_NCI-GLOSS:CDR0000046379
database_cross_reference: NCI_NICHD:C13317
database_cross_reference: RCD:Xa1Xu
database_cross_reference: SNM:T-01414
database_cross_reference: SNMI:T-01414
database_cross_reference: SNOMEDCT_US:67290009
database_cross_reference: UWDA:70660

Pigment Epithelium of Eye
type: Class
subclass of: Epithelium
PMOID: PMO:00000231
Subclass_of: Epithelium
Synonym: Eye Pigment Epithelium
Tree Number: T1.3.5.4
database_cross_reference: MSH:D010857

Seminiferous Epithelium
type: Class
subclass of: Epithelium
PMOID: PMO:00000232
Subclass_of: Epithelium
Synonym: Epithelium, Seminiferous
Synonym: Epitheliums, Seminiferous
Synonym: Seminiferous Epitheliums
Synonym: Spermatogenic epithelium
Synonym: Structure of spermatogenic epithelium
Synonym: Structure of spermatogenic epithelium (body structure)
Tree Number: T1.3.5.5
database_cross_reference: MSH:D012670
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C49296
database_cross_reference: SNM:T-78120
database_cross_reference: SNMI:T-94120
database_cross_reference: SNOMEDCT_US:53472008

Urothelium
type: Class
subclass of: Epithelium
PMOID: PMO:00000233
Subclass_of: Epithelium
Synonym: Epithelium, Urinary Tract
Synonym: Transitional Epithelium of the Urinary Tract
Synonym: Urinary Tract Epithelium
Synonym: Urinary tract transitional epithelium
Synonym: Uroepithelium
Synonym: Urothelium (body structure)
Synonym: Urothelium, NOS
Synonym: urothelium
Tree Number: T1.3.5.6
database_cross_reference: CSP:3045-6697
database_cross_reference: FMA:67695
database_cross_reference: MSH:D019459
database_cross_reference: NCI:C12884
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044975
database_cross_reference: SNM:T-70130
database_cross_reference: SNMI:T-70030
database_cross_reference: SNOMEDCT_US:57789003
database_cross_reference: UWDA:67695

Epithelium, Corneal
type: Class
subclass of: Epithelium
PMOID: PMO:00000234
Subclass_of: Epithelium
Synonym: Anterior Corneal Epithelium
Synonym: Anterior corneal epithelium
Synonym: Cornea, external epithelium
Synonym: Corneal Epithelium
Synonym: Corneal Epithelium, Anterior
Synonym: Corneal epithelium
Synonym: Epithelium anterius (Cornea)
Synonym: Epithelium anterius corneae
Synonym: Epithelium of cornea
Synonym: Epithelium, Anterior Corneal
Tree Number: T1.3.5.7
database_cross_reference: CHV:0000036892
database_cross_reference: CSP:1109-5183
database_cross_reference: FMA:58263
database_cross_reference: MSH:D019573
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12928
database_cross_reference: SNM:T-XX220
database_cross_reference: SNMI:T-AA220
database_cross_reference: SNOMEDCT_US:15775008
database_cross_reference: UWDA:58263

Exocrine Glands
type: Class
subclass of: Tissues
PMOID: PMO:00000235
Subclass_of: Tissues
Synonym: Apocrine
Synonym: Apocrine Gland
Synonym: Ducted gland
Synonym: Exocrine Gland
Synonym: Exocrine gland
Synonym: Exocrine gland structure
Synonym: Exocrine gland structure (body structure)
Synonym: Exocrine glands
Synonym: Gland, Exocrine
Synonym: Glands, Exocrine
Tree Number: T1.3.6
database_cross_reference: AOD:0000016940
database_cross_reference: CHV:0000004770
database_cross_reference: CSP:2935-4372
database_cross_reference: FMA:9596
database_cross_reference: LCH:U001704
database_cross_reference: LCH_NW:sh85046385
database_cross_reference: MSH:D005088
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12712
database_cross_reference: NCI_NCI-GLOSS:CDR0000335062
database_cross_reference: SNOMEDCT_US:362938003
database_cross_reference: UWDA:9596

Bartholin's Glands
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000236
Subclass_of: Exocrine Glands
Synonym: BARTHOLIN GLAND
Synonym: Bartholin Gland
Synonym: Bartholin Glands
Synonym: Bartholin gland
Synonym: Bartholin gland structure
Synonym: Bartholin's Gland
Synonym: Bartholin's gland
Synonym: Bartholin's gland structure
Synonym: Bartholin's gland structure (body structure)
Synonym: Bartholins Glands
Tree Number: T1.3.6.1
database_cross_reference: AOD:0000017422
database_cross_reference: CCPSS:0061348
database_cross_reference: CHV:0000001710
database_cross_reference: FMA:9598
database_cross_reference: LCH:U000502
database_cross_reference: LCH_NW:sh85011986
database_cross_reference: MSH:D001472
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12675
database_cross_reference: SNM:T-80500
database_cross_reference: SNMI:T-81510
database_cross_reference: SNOMEDCT_US:181443008
database_cross_reference: SNOMEDCT_US:87176006
database_cross_reference: UWDA:9598

Bulbourethral Glands
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000237
Subclass_of: Exocrine Glands
Synonym: Bulbo-urethral gland
Synonym: Bulbourethral Gland
Synonym: Bulbourethral gland
Synonym: Bulbourethral gland structure
Synonym: Bulbourethral gland structure (body structure)
Synonym: Cowper Gland
Synonym: Cowper Glands
Synonym: Cowper gland
Synonym: Cowper's Gland
Synonym: Cowper's Glands
Tree Number: T1.3.6.2
database_cross_reference: AOD:0000017431
database_cross_reference: AOD:0000017433
database_cross_reference: CHV:0000002215
database_cross_reference: FMA:9599
database_cross_reference: LCH_NW:sh85033663
database_cross_reference: MSH:D002030
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32395
database_cross_reference: NCI_CDISC:C32395
database_cross_reference: RCD:Xa0tm
database_cross_reference: RCD:Xa188
database_cross_reference: SNM:T-75170
database_cross_reference: SNMI:T-75170
database_cross_reference: SNOMEDCT_US:66997005
database_cross_reference: UWDA:9599

Lacrimal Apparatus
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000238
Subclass_of: Exocrine Glands
Synonym: Apparatus lacrimalis
Synonym: Apparatus, Lacrimal
Synonym: Lacrimal apparatus
Synonym: Lacrimal apparatus structure
Synonym: Lacrimal apparatus structure (body structure)
Synonym: Lacrimal system
Synonym: lacrimal apparatus
Synonym: lacrimal system
Tree Number: T1.3.6.3
database_cross_reference: CHV:0000007174
database_cross_reference: CSP:1110-5953
database_cross_reference: FMA:55605
database_cross_reference: LCH_NW:sh85073848
database_cross_reference: LNC:LP30525-7
database_cross_reference: LNC:MTHU015047
database_cross_reference: MSH:D007765
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32905
database_cross_reference: RCD:7N136
database_cross_reference: SNM:T-XX900
database_cross_reference: SNMI:T-AA900
database_cross_reference: SNOMEDCT_US:27760002
database_cross_reference: UWDA:55605

Mammary Glands, Animal
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000239
Subclass_of: Exocrine Glands
Tree Number: T1.3.6.4

Prostate
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000240
Subclass_of: Exocrine Glands
Synonym: 92 PROSTATE
Synonym: Genital System, Male, Prostate
Synonym: PROSTATE
Synonym: PROSTATE GLAND
Synonym: PROSTATIC
Synonym: Prostata
Synonym: Prostata (Glandula prostatica)
Synonym: Prostate Gland
Synonym: Prostate gland
Synonym: Prostate, NOS
Tree Number: T1.3.6.5
database_cross_reference: AOD:0000017436
database_cross_reference: CCPSS:0022563
database_cross_reference: CCPSS:0023098
database_cross_reference: CHV:0000010223
database_cross_reference: CSP:2587-5599
database_cross_reference: FMA:9600
database_cross_reference: LCH:U006564
database_cross_reference: LCH_NW:sh85107605
database_cross_reference: LNC:LP200001-8
database_cross_reference: LNC:LP7501-2
database_cross_reference: LNC:MTHU004957
database_cross_reference: MSH:D011467
database_cross_reference: MTH:U002195
database_cross_reference: NCI:C12410
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12410
database_cross_reference: NCI_NCI-GLOSS:CDR0000046539
database_cross_reference: NCI_NICHD:C12410
database_cross_reference: PSY:41140
database_cross_reference: RCD:7N511
database_cross_reference: RCD:XC0B1
database_cross_reference: RCD:XM0Q4
database_cross_reference: SNM:T-77100
database_cross_reference: SNMI:T-92000
database_cross_reference: SNOMEDCT_US:263847000
database_cross_reference: SNOMEDCT_US:279689003
database_cross_reference: SNOMEDCT_US:41216001
database_cross_reference: SNOMEDCT_VET:279689003
database_cross_reference: UWDA:9600

Salivary Glands
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000241
Subclass_of: Exocrine Glands
Synonym: 5-20 DISEASES OF THE SALIVARY GLANDS
Synonym: DISEASES OF THE SALIVARY GLANDS
Synonym: Disease of salivary gland
Synonym: Disease of salivary gland (disorder)
Synonym: Disease of salivary gland, NOS
Synonym: Disease of salivary gland, unspecified
Synonym: Disease of salivary glands
Synonym: Disease, Salivary Gland
Synonym: Diseases of salivary glands
Synonym: Diseases of the salivary glands
Tree Number: T1.3.6.6
database_cross_reference: CCPSS:0037756
database_cross_reference: CHV:0000011008
database_cross_reference: CSP:2139-2285
database_cross_reference: CST:DIG/SAL
database_cross_reference: HPO:HP:0010286
database_cross_reference: ICD10:K11
database_cross_reference: ICD10:K11.9
database_cross_reference: ICD10AM:K11
database_cross_reference: ICD10AM:K11.9
database_cross_reference: ICD10CM:K11
database_cross_reference: ICD10CM:K11.9
database_cross_reference: ICD9CM:527
database_cross_reference: ICD9CM:527.9
database_cross_reference: LCH_NW:sh85116808
database_cross_reference: MDR:10013136
database_cross_reference: MDR:10039405
database_cross_reference: MDR:10045759
database_cross_reference: MDR:10061935
database_cross_reference: MEDCIN:210394
database_cross_reference: MEDLINEPLUS:388
database_cross_reference: MSH:D012466
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C26879
database_cross_reference: NDFRT:N0000002662
database_cross_reference: RCD:J07..
database_cross_reference: RCD:J07z.
database_cross_reference: SNM:D-6120
database_cross_reference: SNMI:D5-20000
database_cross_reference: SNOMEDCT_US:10890000
database_cross_reference: SNOMEDCT_US:155654009
database_cross_reference: SNOMEDCT_US:155658007
database_cross_reference: SNOMEDCT_US:196526006

Parotid Gland
type: Class
subclass of: Salivary Glands
PMOID: PMO:00000242
Subclass_of: Salivary Glands
Synonym: 611 PAROTID GLANDS
Synonym: GLAND, SALIVARY, PAROTID
Synonym: Gland, Parotid
Synonym: Glands, Parotid
Synonym: Glandula parotidea
Synonym: Neck>Parotid gland
Synonym: PAROTID GLAND
Synonym: PAROTID GLANDS
Synonym: Parotid
Synonym: Parotid Glands
Tree Number: T1.3.6.6.1
database_cross_reference: AOD:0000017249
database_cross_reference: CHV:0000009324
database_cross_reference: CSP:2139-1813
database_cross_reference: FMA:59790
database_cross_reference: LCH:U003489
database_cross_reference: LCH_NW:sh85098268
database_cross_reference: LNC:LA4653-7
database_cross_reference: LNC:LP207335-3
database_cross_reference: LNC:LP33682-3
database_cross_reference: LNC:MTHU051972
database_cross_reference: MSH:D010306
database_cross_reference: MTH:U002146
database_cross_reference: NCI:C12427
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12427
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C12427
database_cross_reference: RCD:7N240
database_cross_reference: SNM:T-55100
database_cross_reference: SNM:U000463
database_cross_reference: SNMI:T-61100
database_cross_reference: SNOMEDCT_US:45289007
database_cross_reference: UWDA:59790

Salivary Glands, Minor
type: Class
subclass of: Salivary Glands
PMOID: PMO:00000243
Subclass_of: Salivary Glands
Synonym: 614 MINOR SALIVARY GLANDS
Synonym: Gland, Minor Salivary
Synonym: Glands, Minor Salivary
Synonym: Glandulae salivariae minores
Synonym: MINOR SALIVARY GLANDS
Synonym: Minor Salivary Gland
Synonym: Minor Salivary Glands
Synonym: Minor salivary gland
Synonym: Minor salivary gland structure
Synonym: Minor salivary gland structure (body structure)
Tree Number: T1.3.6.6.2
database_cross_reference: CHV:0000011012
database_cross_reference: FMA:59789
database_cross_reference: FMA:71612
database_cross_reference: MSH:D012470
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33129
database_cross_reference: SNM:T-55400
database_cross_reference: SNM:U000465
database_cross_reference: SNMI:T-61400
database_cross_reference: SNOMEDCT_US:87626005
database_cross_reference: UWDA:59789
database_cross_reference: UWDA:71612

Sublingual Gland
type: Class
subclass of: Salivary Glands
PMOID: PMO:00000244
Subclass_of: Salivary Glands
Synonym: 612 SUBLINGUAL GLANDS
Synonym: Ductus sublingualis
Synonym: GLAND, SALIVARY, SUBLINGUAL
Synonym: Gland, Sublingual
Synonym: Glands, Sublingual
Synonym: Glandula sublingualis
Synonym: Rivinus' gland
Synonym: SUBLINGUAL GLANDS
Synonym: Sublingual Glands
Synonym: Sublingual Salivary Gland
Tree Number: T1.3.6.6.3
database_cross_reference: AOD:0000017250
database_cross_reference: CHV:0000011814
database_cross_reference: CSP:2139-1872
database_cross_reference: FMA:59791
database_cross_reference: LCH:U004515
database_cross_reference: LCH_NW:sh85129479
database_cross_reference: MSH:D013361
database_cross_reference: MTH:U002271
database_cross_reference: NCI:C12234
database_cross_reference: NCI_CDISC:C12234
database_cross_reference: SNM:T-55200
database_cross_reference: SNM:U000464
database_cross_reference: SNMI:T-61200
database_cross_reference: SNOMEDCT_US:88481005
database_cross_reference: UWDA:59791

Submandibular Gland
type: Class
subclass of: Salivary Glands
PMOID: PMO:00000245
Subclass_of: Salivary Glands
Synonym: 613 SUBMAXILLARY GLANDS
Synonym: GLAND, SALIVARY, SUBMANDIBULAR
Synonym: Gland, Salivary, Mandibular
Synonym: Gland, Submandibular
Synonym: Gland, Submaxillary
Synonym: Glands, Submandibular
Synonym: Glands, Submaxillary
Synonym: Glandula submandibularis
Synonym: SMG - Submandibular gland
Synonym: SUBMAXILLARY GLANDS
Tree Number: T1.3.6.6.4
database_cross_reference: AOD:0000017252
database_cross_reference: CHV:0000011815
database_cross_reference: CSP:2139-1931
database_cross_reference: FMA:55093
database_cross_reference: LCH:U004516
database_cross_reference: LCH_NW:sh85129482
database_cross_reference: LNC:LP34302-7
database_cross_reference: LNC:MTHU017267
database_cross_reference: MSH:D013363
database_cross_reference: MTH:U002272
database_cross_reference: NCI:C12233
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12233
database_cross_reference: RCD:7N241
database_cross_reference: RCD:Xa3XV
database_cross_reference: SNM:NOCODE
database_cross_reference: SNM:T-55300
database_cross_reference: SNMI:T-61300
database_cross_reference: SNOMEDCT_US:385296007
database_cross_reference: SNOMEDCT_US:54019009
database_cross_reference: UWDA:55093

Salivary Ducts
type: Class
subclass of: Salivary Glands
PMOID: PMO:00000246
Subclass_of: Salivary Glands
Synonym: Duct of salivary gland
Synonym: Duct, Salivary
Synonym: Ducts, Salivary
Synonym: Salivary Duct
Synonym: Salivary duct
Synonym: Salivary duct structure
Synonym: Salivary duct structure (body structure)
Synonym: Salivary duct, NOS
Synonym: Salivary gland duct
Synonym: Salivary gland duct, NOS
Tree Number: T1.3.6.6.5
database_cross_reference: CHV:0000027656
database_cross_reference: FMA:59908
database_cross_reference: MSH:D018987
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:7N245
database_cross_reference: RCD:XaCxG
database_cross_reference: SNM:T-55080
database_cross_reference: SNMI:T-61080
database_cross_reference: SNOMEDCT_US:181232003
database_cross_reference: SNOMEDCT_US:86961006
database_cross_reference: UWDA:59908

von Ebner Glands
type: Class
subclass of: Salivary Glands
PMOID: PMO:00000247
Subclass_of: Salivary Glands
Synonym: Ebner Glands, von
Synonym: Gland of von Ebner
Synonym: Gland, von Ebner's
Synonym: Glands, von Ebner
Synonym: Glands, von Ebner's
Synonym: Posterior lingual gland
Synonym: von Ebner Gland
Synonym: von Ebner's Gland
Synonym: von Ebner's Glands
Synonym: von Ebners Gland
Tree Number: T1.3.6.6.6
database_cross_reference: FMA:293448
database_cross_reference: MSH:D054838

Sebaceous Glands
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000248
Subclass_of: Exocrine Glands
Synonym: GLAND, SEBACEOUS
Synonym: Gland, Sebaceous
Synonym: Glands of Zeis
Synonym: Glands, Sebaceous
Synonym: Glandula sebacea
Synonym: Glandulae sebaceae
Synonym: SEBACEOUS GLAND
Synonym: Sebaceous Gland
Synonym: Sebaceous gland
Synonym: Sebaceous gland structure
Tree Number: T1.3.6.7
database_cross_reference: AOD:0000017148
database_cross_reference: CHV:0000011147
database_cross_reference: CSP:2716-1621
database_cross_reference: FMA:59160
database_cross_reference: FMA:71874
database_cross_reference: LCH:U004250
database_cross_reference: LCH_NW:sh85119389
database_cross_reference: MSH:D012627
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33519
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C33519
database_cross_reference: SNM:T-01310
database_cross_reference: SNMI:T-01310
database_cross_reference: SNOMEDCT_US:1028005
database_cross_reference: UWDA:59160
database_cross_reference: UWDA:71874

Meibomian Glands
type: Class
subclass of: Sebaceous Glands
PMOID: PMO:00000249
Subclass_of: Sebaceous Glands
Synonym: GLAND, MEIBOMIAN
Synonym: Gland of Meibom
Synonym: Gland, Meibomian
Synonym: Gland, Tarsal
Synonym: Glands, Meibomian
Synonym: Glands, Tarsal
Synonym: Glandulae tarsales
Synonym: Meibomian Gland
Synonym: Meibomian gland
Synonym: Meibomian glands
Tree Number: T1.3.6.7.1
database_cross_reference: CHV:0000007887
database_cross_reference: FMA:59104
database_cross_reference: FMA:71872
database_cross_reference: LCH:U002884
database_cross_reference: LCH_NW:sh85083334
database_cross_reference: MSH:D008537
database_cross_reference: MTH:474
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33075
database_cross_reference: NCI_CDISC:C33075
database_cross_reference: RCD:Xa1TO
database_cross_reference: SNM:T-XX850
database_cross_reference: SNMI:T-AA850
database_cross_reference: SNOMEDCT_US:1110006
database_cross_reference: UWDA:59104
database_cross_reference: UWDA:71872

Sweat Glands
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000250
Subclass_of: Exocrine Glands
Synonym: Gland, Sweat
Synonym: Glands, Sweat
Synonym: Glandula sudorifera
Synonym: SUDORIFEROUS GLAND
Synonym: Sudoriferous Gland
Synonym: Sudoriferous gland
Synonym: Sudoriferous gland, NOS
Synonym: Sweat Gland
Synonym: Sweat gland
Synonym: Sweat gland structure
Tree Number: T1.3.6.8
database_cross_reference: AOD:0000017142
database_cross_reference: AOD:0000027708
database_cross_reference: CHV:0000011951
database_cross_reference: CSP:2716-1933
database_cross_reference: FMA:59152
database_cross_reference: LCH:U004547
database_cross_reference: LCH_NW:sh85131026
database_cross_reference: MSH:D013545
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33712
database_cross_reference: NCI_CDISC:C33712
database_cross_reference: NCI_NICHD:C33712
database_cross_reference: SNMI:T-01380
database_cross_reference: SNOMEDCT_US:10410005
database_cross_reference: UWDA:59152

Apocrine Glands
type: Class
subclass of: Sweat Glands
PMOID: PMO:00000251
Subclass_of: Sweat Glands
Synonym: Apocrine Gland
Synonym: Apocrine gland
Synonym: Apocrine gland structure
Synonym: Apocrine gland structure (body structure)
Synonym: Apocrine gland, NOS
Synonym: Apocrine glands
Synonym: Gland, Apocrine
Synonym: Glands, Apocrine
Synonym: apocrine gland
Synonym: apocrine glands
Tree Number: T1.3.6.8.1
database_cross_reference: CHV:0000001379
database_cross_reference: LCH:U000330
database_cross_reference: LCH_NW:sh85006004
database_cross_reference: MSH:D001050
database_cross_reference: MTH:NOCODE
database_cross_reference: SNM:T-01320
database_cross_reference: SNMI:T-01320
database_cross_reference: SNOMEDCT_US:2789006

Eccrine Glands
type: Class
subclass of: Sweat Glands
PMOID: PMO:00000252
Subclass_of: Sweat Glands
Synonym: Eccrine Gland
Synonym: Eccrine Sweat Gland
Synonym: Eccrine gland
Synonym: Eccrine gland structure
Synonym: Eccrine gland structure (body structure)
Synonym: Eccrine gland, NOS
Synonym: Eccrine sweat gland
Synonym: Gland, Eccrine
Synonym: Glands, Eccrine
Synonym: eccrine gland
Tree Number: T1.3.6.8.2
database_cross_reference: CHV:0000004241
database_cross_reference: FMA:59154
database_cross_reference: MSH:D004439
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32490
database_cross_reference: NCI_NCI-GLOSS:CDR0000393531
database_cross_reference: SNM:T-01330
database_cross_reference: SNMI:T-01330
database_cross_reference: SNOMEDCT_US:2759004
database_cross_reference: UWDA:59154

Pancreas, Exocrine
type: Class
subclass of: Exocrine Glands
PMOID: PMO:00000253
Subclass_of: Exocrine Glands
Synonym: Exocrine Pancreas
Synonym: Exocrine pancreas
Synonym: Exocrine pancreas, NOS
Synonym: PANCREAS, EXOCRINE
Synonym: Pars exocrina pancreatis
Synonym: Structure of exocrine pancreas
Synonym: Structure of exocrine pancreas (body structure)
Synonym: exocrine pancreas
Tree Number: T1.3.6.10
database_cross_reference: AOD:0000017308
database_cross_reference: CSP:2201-8988
database_cross_reference: CSP:4000-0104
database_cross_reference: FMA:16017
database_cross_reference: LNC:LP31813-6
database_cross_reference: MSH:D046790
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32546
database_cross_reference: NCI_CDISC:C32546
database_cross_reference: NCI_NICHD:C32546
database_cross_reference: SNM:T-59005
database_cross_reference: SNMI:T-65005
database_cross_reference: SNOMEDCT_US:20023005
database_cross_reference: UWDA:16017

Lymphoid Tissue
type: Class
subclass of: Tissues
PMOID: PMO:00000254
Subclass_of: Tissues
Synonym: Lymphatic Tissue
Synonym: Lymphatic Tissues
Synonym: Lymphatic tissue
Synonym: Lymphatic tissue (body structure)
Synonym: Lymphocytic tissue
Synonym: Lymphocytic tissue structure
Synonym: Lymphocytic tissue structure (body structure)
Synonym: Lymphoid Tissues
Synonym: Lymphoid tissue
Synonym: Tissue, Lymphatic
Tree Number: T1.3.7
database_cross_reference: AOD:0000027945
database_cross_reference: AOD:0000027946
database_cross_reference: CHV:0000007615
database_cross_reference: CSP:0432-5082
database_cross_reference: FMA:55220
database_cross_reference: LCH:U002764
database_cross_reference: LCH_NW:sh85079152
database_cross_reference: MSH:D008221
database_cross_reference: NCI:C13049
database_cross_reference: RCD:7N8A2
database_cross_reference: SNM:T-05200
database_cross_reference: SNMI:T-C0200
database_cross_reference: SNOMEDCT_US:181768009
database_cross_reference: SNOMEDCT_US:6969002
database_cross_reference: UWDA:55220

Tertiary Lymphoid Structures
type: Class
subclass of: Lymphoid Tissue
PMOID: PMO:00000255
Subclass_of: Lymphoid Tissue
Synonym: Ectopic Lymph Node
Synonym: Ectopic Lymph Nodes
Synonym: Ectopic Lymphoid Follicle
Synonym: Ectopic Lymphoid Follicles
Synonym: Ectopic Lymphoid Formation
Synonym: Ectopic Lymphoid Formations
Synonym: Ectopic Lymphoid Like Structures
Synonym: Ectopic Lymphoid Organ
Synonym: Ectopic Lymphoid Organs
Synonym: Ectopic Lymphoid Tissue
Tree Number: T1.3.7.1
database_cross_reference: MSH:D000072717
database_cross_reference: NDFRT:N0000192935

Adenoids
type: Class
subclass of: Lymphoid Tissue
PMOID: PMO:00000256
Subclass_of: Lymphoid Tissue
Synonym: Adenoid
Synonym: Adenoid, NOS
Synonym: Adenoidal
Synonym: Adenoidal structure
Synonym: Adenoidal structure (body structure)
Synonym: Nasopharyngeal tonsil
Synonym: PHARYNGEAL TONSIL
Synonym: Pharyngeal Tonsil
Synonym: Pharyngeal Tonsils
Synonym: Pharyngeal tonsil
Tree Number: T1.3.7.2
database_cross_reference: CHV:0000000714
database_cross_reference: CSP:0432-5082
database_cross_reference: FMA:54970
database_cross_reference: LCH:U000065
database_cross_reference: LCH_NW:sh85000840
database_cross_reference: MEDLINEPLUS:1515
database_cross_reference: MSH:D000234
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33318
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C33318
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C33318
database_cross_reference: RCD:7N204
database_cross_reference: RCD:Xa1e0
database_cross_reference: SNM:T-61300
database_cross_reference: SNMI:T-C5300
database_cross_reference: SNOMEDCT_US:55940004
database_cross_reference: UWDA:54970

Bursa of Fabricius
type: Class
subclass of: Lymphoid Tissue
PMOID: PMO:00000257
Subclass_of: Lymphoid Tissue
Synonym: BURSA OF FABRICIUS
Synonym: Bursa Fabricii
Synonym: Bursa Of Fabricius
Synonym: Bursa of Fabricius (body structure)
Synonym: Bursa of Fabricius structure
Synonym: Bursa of Fabricius structure (body structure)
Synonym: Fabricius Bursa
Synonym: bursa fabricius
Synonym: bursa of Fabricius
Synonym: bursa of fabricius
Tree Number: T1.3.7.3
database_cross_reference: CHV:0000002239
database_cross_reference: CSP:0432-5279
database_cross_reference: LCH_NW:sh85018202
database_cross_reference: LNC:LP7094-8
database_cross_reference: LNC:MTHU011078
database_cross_reference: MSH:D002060
database_cross_reference: NCI:C111141
database_cross_reference: NCI_CDISC:C111141
database_cross_reference: SNMI:T-C9010
database_cross_reference: SNOMEDCT_US:86689007
database_cross_reference: SNOMEDCT_VET:349371000009108

Lymph Nodes
type: Class
subclass of: Lymphoid Tissue
PMOID: PMO:00000258
Subclass_of: Lymphoid Tissue
Synonym: C4 LYMPH NODES
Synonym: LN - Lymph node
Synonym: LYMPH NODE
Synonym: LYMPH NODES
Synonym: Lymph Gland
Synonym: Lymph Node
Synonym: Lymph Node Structures
Synonym: Lymph gland
Synonym: Lymph gland, NOS
Synonym: Lymph node
Tree Number: T1.3.7.4
database_cross_reference: AOD:0000017506
database_cross_reference: CHV:0000007593
database_cross_reference: CSP:0432-5673
database_cross_reference: FMA:5034
database_cross_reference: ICD10AM:U000976
database_cross_reference: LCH:U002755
database_cross_reference: LCH_NW:sh85079126
database_cross_reference: LNC:LP199987-1
database_cross_reference: LNC:LP238883-5
database_cross_reference: LNC:LP72888-8
database_cross_reference: LNC:MTHU015050
database_cross_reference: LNC:MTHU055419
database_cross_reference: MEDLINEPLUS:591
database_cross_reference: MSH:D008198
database_cross_reference: MTH:U002055
database_cross_reference: NCI:C12745
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12745
database_cross_reference: NCI_NCI-GLOSS:CDR0000044489
database_cross_reference: NCI_NCI-GLOSS:CDR0000045762
database_cross_reference: NCI_NICHD:C12745
database_cross_reference: RCD:7N89.
database_cross_reference: RCD:Xa16Q
database_cross_reference: SNM:NOCODE
database_cross_reference: SNM:T-08000
database_cross_reference: SNM:U000418
database_cross_reference: SNMI:T-C4000
database_cross_reference: SNOMEDCT_US:59441001
database_cross_reference: UWDA:5034

Sentinel Lymph Node
type: Class
subclass of: Lymph Nodes
PMOID: PMO:00000259
Subclass_of: Lymph Nodes
Synonym: Lymph Node, Sentinel
Synonym: Lymph Nodes, Sentinel
Synonym: Node, Sentinal
Synonym: Nodes, Sentinal
Synonym: SLN
Synonym: Sentinal Node
Synonym: Sentinal Nodes
Synonym: Sentinel Lymph Nodes
Synonym: Sentinel Node
Synonym: sentinel lymph node
Tree Number: T1.3.7.4.1
database_cross_reference: MSH:D000071036
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12947
database_cross_reference: NCI_NCI-GLOSS:CDR0000045876

Germinal Center
type: Class
subclass of: Lymph Nodes
PMOID: PMO:00000260
Subclass_of: Lymph Nodes
Synonym: Center, Germinal
Synonym: Centers, Germinal
Synonym: Germinal Centers
Synonym: Germinal center
Synonym: Germinal center of lymph node
Synonym: Germinal centre of lymph node
Synonym: Lymph Node Germinal Center
Synonym: Lymph node germinal center
Synonym: Peripheral lymphoid tissue
Synonym: Secondary lymphoid nodule
Tree Number: T1.3.7.4.2
database_cross_reference: CHV:0000027610
database_cross_reference: FMA:55224
database_cross_reference: MSH:D018858
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13337
database_cross_reference: NCI:C49757
database_cross_reference: SNM:T-08060
database_cross_reference: SNMI:T-C4060
database_cross_reference: SNOMEDCT_US:16733004
database_cross_reference: UWDA:55224

Dendritic Cells, Follicular
type: Class
subclass of: Antigen-Presenting Cells
PMOID: PMO:00000261
Subclass_of: Antigen-Presenting Cells
Synonym: Dendritic Cell, Follicular
Synonym: Dendritic Reticulum Cells, Follicular
Synonym: Dendritic reticulum cell
Synonym: Follicular Dendritic Cell
Synonym: Follicular Dendritic Cells
Synonym: Follicular dendritic cell
Synonym: Follicular dendritic cell (body structure)
Synonym: Follicular dendritic cell (cell)
Synonym: Reticulum cell, dendritic
Synonym: follicular dendritic cell
Tree Number: T2.3.2
database_cross_reference: CHV:0000024750
database_cross_reference: FMA:83037
database_cross_reference: MSH:D020566
database_cross_reference: NCI:C12622
database_cross_reference: SNM:T-05111
database_cross_reference: SNMI:T-C0111
database_cross_reference: SNOMEDCT_US:56685008

Peyer's Patches
type: Class
subclass of: Lymphoid Tissue
PMOID: PMO:00000262
Subclass_of: Lymphoid Tissue
Synonym: Aggregated lymphoid follicle of small intestine
Synonym: Aggregated lymphoid nodules of small intestine
Synonym: Lymphoid aggregate
Synonym: Lymphoid aggregate (body structure)
Synonym: Lymphoid aggregate [dup] (body structure)
Synonym: Noduli lymphoidei aggregati intestini tenuis
Synonym: PEYER'S PATCH
Synonym: Patches, Peyer's
Synonym: Peyer Patch
Synonym: Peyer Patches
Tree Number: T1.3.7.5
database_cross_reference: AOD:0000017290
database_cross_reference: AOD:0000027779
database_cross_reference: CHV:0000009564
database_cross_reference: CSP:0432-5931
database_cross_reference: FMA:15054
database_cross_reference: FMA:76466
database_cross_reference: MSH:D010581
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12771
database_cross_reference: NCI_CDISC:C12771
database_cross_reference: SNM:T-64080
database_cross_reference: SNM:T-64082
database_cross_reference: SNMI:T-58082
database_cross_reference: SNOMEDCT_US:267190001
database_cross_reference: SNOMEDCT_US:304496003
database_cross_reference: SNOMEDCT_US:305467006
database_cross_reference: SNOMEDCT_US:57253005
database_cross_reference: UWDA:15054
database_cross_reference: UWDA:76466

Spleen
type: Class
subclass of: Lymphoid Tissue
PMOID: PMO:00000263
Subclass_of: Lymphoid Tissue
Synonym: C3 SPLEEN
Synonym: Lien
Synonym: Lienal
Synonym: Lieno-
Synonym: Reticuloendothelial System, Spleen
Synonym: SPLEEN
Synonym: Spleen, NOS
Synonym: Splen
Synonym: Splenic
Synonym: Splenic structure
Tree Number: T1.3.7.6
database_cross_reference: AOD:0000004631
database_cross_reference: CHV:0000011640
database_cross_reference: CSP:0432-8431
database_cross_reference: FMA:7196
database_cross_reference: LCH:U004439
database_cross_reference: LCH_NW:sh85126812
database_cross_reference: LNC:LA26010-1
database_cross_reference: LNC:LP199947-5
database_cross_reference: LNC:LP30311-2
database_cross_reference: LNC:MTHU012104
database_cross_reference: MSH:D013154
database_cross_reference: MTH:U002266
database_cross_reference: NCI:C12432
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12432
database_cross_reference: NCI_NCI-GLOSS:CDR0000046593
database_cross_reference: NCI_NCI-GLOSS:CDR0000467863
database_cross_reference: NCI_NICHD:C12432
database_cross_reference: OMIM:MTHU000222
database_cross_reference: PSY:49320
database_cross_reference: RCD:7N342
database_cross_reference: RCD:Xa0am
database_cross_reference: SNM:T-07000
database_cross_reference: SNM:U000417
database_cross_reference: SNMI:T-C3000
database_cross_reference: SNOMEDCT_US:78961009
database_cross_reference: UWDA:7196

Thymus Gland
type: Class
subclass of: Lymphoid Tissue
PMOID: PMO:00000264
Subclass_of: Lymphoid Tissue
Synonym: Extract, Thymus
Synonym: Extracts, Thymus
Synonym: HUMAN THYMUS
Synonym: THYMUS
Synonym: Thymus Extract
Synonym: Thymus Extracts
Synonym: Thymus Extracts [Chemical/Ingredient]
Synonym: Thymus extract
Synonym: Thymus gland
Synonym: gland thymus
Tree Number: T1.3.7.7
database_cross_reference: AOD:0000018972
database_cross_reference: CHV:0000012250
database_cross_reference: LCH:U004681
database_cross_reference: LCH_NW:sh85135146
database_cross_reference: LNC:LP36529-3
database_cross_reference: MSH:D013949
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9CC998Z1E1
database_cross_reference: NDDF:007062
database_cross_reference: NDFRT:N0000022939
database_cross_reference: NDFRT:N0000170927
database_cross_reference: RXNORM:10562
database_cross_reference: VANDF:4020844

Palatine Tonsil
type: Class
subclass of: Lymphoid Tissue
PMOID: PMO:00000265
Subclass_of: Lymphoid Tissue
Synonym: Faucial tonsil
Synonym: Palatine Tonsils
Synonym: Palatine tonsil
Synonym: TONSIL
Synonym: TONSIL, PALATINE
Synonym: Tonsil
Synonym: Tonsil, NOS
Synonym: Tonsil, Palatine
Synonym: Tonsilla palatina
Synonym: Tonsillar
Tree Number: T1.3.7.8
database_cross_reference: CCPSS:0035921
database_cross_reference: CHV:0000012359
database_cross_reference: CSP:2139-1223
database_cross_reference: CSP:4000-0195
database_cross_reference: FMA:9610
database_cross_reference: LCH:U004722
database_cross_reference: LCH_NW:sh85136024
database_cross_reference: MSH:D014066
database_cross_reference: MTH:U002313
database_cross_reference: NCI:C33250
database_cross_reference: NCI_CDISC:C33250
database_cross_reference: RCD:XE0K3
database_cross_reference: RCD:Xa1e2
database_cross_reference: SNM:T-61100
database_cross_reference: SNMI:T-C5100
database_cross_reference: SNOMEDCT_US:181228009
database_cross_reference: SNOMEDCT_US:75573002
database_cross_reference: UWDA:9610

Membranes
type: Class
subclass of: Tissues
PMOID: PMO:00000266
Subclass_of: Tissues
Synonym: Membrane
Synonym: Membrane Tissue
Synonym: Membrane Tissues
Synonym: Membranous
Synonym: Tissue membrane
Synonym: Tissue, Membrane
Synonym: Tissues, Membrane
Synonym: membrane
Synonym: membranes
Tree Number: T1.3.8
database_cross_reference: CHV:0000007915
database_cross_reference: FMA:30322
database_cross_reference: MSH:D008566
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12749
database_cross_reference: NCI_NCI-GLOSS:CDR0000046294
database_cross_reference: PSY:30560
database_cross_reference: UWDA:30322

Basilar Membrane
type: Class
subclass of: Basement Membrane
PMOID: PMO:00000267
Subclass_of: Basement Membrane
Synonym: BM - Basilar membrane
Synonym: Basilar Membranes
Synonym: Basilar membrane
Synonym: Basilar membrane of cochlea
Synonym: Cochlea, basilar membrane
Synonym: Membrane, Basilar
Synonym: Membranes, Basilar
Synonym: Structure of basilar membrane of cochlea
Synonym: Structure of basilar membrane of cochlea (body structure)
Tree Number: T1.3.8.1.1
database_cross_reference: FMA:75706
database_cross_reference: LCH:U000509
database_cross_reference: LCH_NW:sh85012090
database_cross_reference: MSH:D001489
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13179
database_cross_reference: RCD:Xa1DG
database_cross_reference: SNM:T-XY802
database_cross_reference: SNMI:T-AB802
database_cross_reference: SNOMEDCT_US:50862003
database_cross_reference: UWDA:75706

Descemet Membrane
type: Class
subclass of: Basement Membrane
PMOID: PMO:00000268
Subclass_of: Basement Membrane
Synonym: Descemet Membranes
Synonym: Descemet's Membrane
Synonym: Descemet's membrane
Synonym: Descemet's posterior elastic lamina
Synonym: Descemets Membrane
Synonym: Elastica Posterior, Lamina
Synonym: Elastica Posteriors, Lamina
Synonym: Lamina Elastica Posterior
Synonym: Lamina Elastica Posteriors
Synonym: Lamina limitans posterior
Tree Number: T1.3.8.1.2
database_cross_reference: FMA:58309
database_cross_reference: MSH:D003886
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32454
database_cross_reference: SNM:T-XX250
database_cross_reference: SNMI:T-AA250
database_cross_reference: SNOMEDCT_US:42983006
database_cross_reference: UWDA:58309

Glomerular Basement Membrane
type: Class
subclass of: Basement Membrane
subclass of: Extracellular Matrix
PMOID: PMO:00000269
Subclass_of: Basement Membrane
Subclass_of: Extracellular Matrix
Synonym: Basement Membrane, Glomerular
Synonym: Basement Membranes, Glomerular
Synonym: GBM
Synonym: Glomerular Basement Membranes
Synonym: Glomerular basement membrane
Synonym: Membrane, Glomerular Basement
Synonym: Membranes, Glomerular Basement
Synonym: basement glomerular membranes
Synonym: glomerular basement membrane
Tree Number: T1.3.8.1.4
Tree Number: T1.4.5.2.3
Tree Number: T2.8.5.2.3
database_cross_reference: CHV:0000042002
database_cross_reference: CSP:1680-0810
database_cross_reference: CSP:1831-6535
database_cross_reference: FMA:74274
database_cross_reference: LNC:LP68423-0
database_cross_reference: MSH:D050533
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32683
database_cross_reference: UWDA:74274

Mucous Membrane
type: Class
subclass of: Membranes
PMOID: PMO:00000270
Subclass_of: Membranes
Synonym: MM - Mucous membrane
Synonym: MUCOSA
Synonym: Membrane, Mucous
Synonym: Membranes, Mucous
Synonym: Mucosa
Synonym: Mucosa of organ
Synonym: Mucosal
Synonym: Mucosal (qualifier value)
Synonym: Mucosal Tissue
Synonym: Mucosal Tissues
Tree Number: T1.3.8.3
database_cross_reference: AOD:0000016909
database_cross_reference: AOD:0000017268
database_cross_reference: AOD:0000027642
database_cross_reference: CSP:1831-7474
database_cross_reference: DRUGBANK:DB00874
database_cross_reference: FMA:85355
database_cross_reference: LCH:U003051
database_cross_reference: LCH_NW:sh85088237
database_cross_reference: LNC:LP30530-7
database_cross_reference: LNC:MTHU015053
database_cross_reference: MSH:D009092
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13166
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13166
database_cross_reference: NCI_NCI-GLOSS:CDR0000257212
database_cross_reference: NCI_NCI-GLOSS:CDR0000257213
database_cross_reference: NCI_NICHD:C13166
database_cross_reference: RCD:X79YP
database_cross_reference: RCD:XaEGv
database_cross_reference: SNMI:T-00400
database_cross_reference: SNOMEDCT_US:313268005
database_cross_reference: SNOMEDCT_US:414781009
database_cross_reference: SNOMEDCT_US:74301006
database_cross_reference: UWDA:45630

Esophageal Mucosa
type: Class
subclass of: Mucous Membrane
PMOID: PMO:00000271
Subclass_of: Mucous Membrane
Synonym: Esophageal mucosa
Synonym: Esophageal mucous membrane
Synonym: Esophageal mucous membrane structure
Synonym: Esophageal mucous membrane structure (body structure)
Synonym: Esophageal mucous membranes
Synonym: Esophagus - mucosa
Synonym: Esophagus Mucosa
Synonym: Esophagus mucosa
Synonym: Lamina muscularis mucosae oesophageae
Synonym: Mucosa of esophagus
Tree Number: T1.3.8.3.1
database_cross_reference: CHV:0000022092
database_cross_reference: CSP:2139-1486
database_cross_reference: FMA:62996
database_cross_reference: MSH:D000071041
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32538
database_cross_reference: NCI:GTEx
database_cross_reference: SNM:T-62010
database_cross_reference: SNMI:T-56010
database_cross_reference: SNOMEDCT_US:82082004
database_cross_reference: UWDA:62996

Gastric Mucosa
type: Class
subclass of: Mucous Membrane
PMOID: PMO:00000272
Subclass_of: Mucous Membrane
Synonym: Gastric Mucosas
Synonym: Gastric mucosa
Synonym: Gastric mucous membrane
Synonym: Gastric mucous membrane structure
Synonym: Gastric mucous membrane structure (body structure)
Synonym: Mucosa of stomach
Synonym: Mucosa, Gastric
Synonym: Mucosas, Gastric
Synonym: Mucous membrane of stomach
Synonym: Tunica mucosa (Gaster)
Tree Number: T1.3.8.3.2
database_cross_reference: AOD:0000017269
database_cross_reference: CHV:0000005372
database_cross_reference: CSP:1250-9110
database_cross_reference: FMA:14907
database_cross_reference: LCH:U001924
database_cross_reference: LCH_NW:sh85053463
database_cross_reference: MSH:D005753
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32656
database_cross_reference: SNM:T-63010
database_cross_reference: SNMI:T-57010
database_cross_reference: SNOMEDCT_US:78653002
database_cross_reference: UWDA:14907

Enterochromaffin Cells
type: Class
subclass of: Enteroendocrine Cells
PMOID: PMO:00000273
Subclass_of: Enteroendocrine Cells
Synonym: 5 HT Containing Enterochromaffin Cells
Synonym: 5-HT-Containing Enterochromaffin Cell
Synonym: 5-HT-Containing Enterochromaffin Cells
Synonym: Argentaffin Cell
Synonym: Argentaffin Cells
Synonym: Argentaffin cell
Synonym: Argentaffin cells
Synonym: Argentaffin cells, NOS
Synonym: Cell, Enterochromaffin
Synonym: Cells, Enterochromaffin
Tree Number: T2.11.7.1
Tree Number: T2.12.21.1
database_cross_reference: CHV:0000004500
database_cross_reference: CSP:0605-5566
database_cross_reference: FMA:83132
database_cross_reference: MSH:D004759
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12575
database_cross_reference: NCI:C32140
database_cross_reference: SNM:T-64140
database_cross_reference: SNMI:T-58140
database_cross_reference: SNOMEDCT_US:3789000

Parietal Cells, Gastric
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000274
Subclass_of: Epithelial Cells
Synonym: Cell, Gastric Parietal
Synonym: Cell, Oxyntic
Synonym: Cells, Gastric Parietal
Synonym: Cells, Oxyntic
Synonym: Gastric Parietal Cell
Synonym: Gastric Parietal Cells
Synonym: Gastric parietal cell
Synonym: Gastric parietal cell (body structure)
Synonym: Gastric parietal cell (cell)
Synonym: Oxyntic Cell
Tree Number: T2.12.12
database_cross_reference: CHV:0000009315
database_cross_reference: FMA:62901
database_cross_reference: LNC:LP16734-3
database_cross_reference: MSH:D010295
database_cross_reference: NCI:C12594
database_cross_reference: SNM:T-63080
database_cross_reference: SNMI:T-57080
database_cross_reference: SNOMEDCT_US:57041003
database_cross_reference: UWDA:62901

Gastrin-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
PMOID: PMO:00000275
Subclass_of: Enteroendocrine Cells
Synonym: Cell, Gastrin-Secreting
Synonym: Cells, Gastrin-Secreting
Synonym: G Cell
Synonym: G Cells
Synonym: G cell
Synonym: G-Cell
Synonym: Gastrin Cell
Synonym: Gastrin Cells
Synonym: Gastrin Secreting Cell
Synonym: Gastrin Secreting Cells
Tree Number: T2.11.7.3
Tree Number: T2.12.21.3
database_cross_reference: CHV:0000038380
database_cross_reference: FMA:67609
database_cross_reference: MSH:D019863
database_cross_reference: NCI:C12577

Somatostatin-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
PMOID: PMO:00000276
Subclass_of: Enteroendocrine Cells
Synonym: D Cell
Synonym: D Cells
Synonym: Delta Cell
Synonym: Delta cell
Synonym: Somatostatin Cell
Synonym: Somatostatin Cells
Synonym: Somatostatin Secreting Cell
Synonym: Somatostatin Secreting Cells
Synonym: Somatostatin-Secreting Cell
Synonym: cell d
Tree Number: T2.11.7.4
Tree Number: T2.12.21.4
database_cross_reference: CHV:0000038381
database_cross_reference: FMA:86572
database_cross_reference: MSH:D019864
database_cross_reference: NCI:C12574

Chief Cells, Gastric
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000277
Subclass_of: Epithelial Cells
Synonym: Cell, Gastric Zymogenic
Synonym: Cells, Gastric Zymogenic
Synonym: Chief Cell of the Stomach
Synonym: Chief Cell, Gastric
Synonym: Chief cell of stomach
Synonym: Gastric Chief Cell
Synonym: Gastric Chief Cells
Synonym: Gastric Zymogenic Cell
Synonym: Gastric Zymogenic Cells
Synonym: Gastric chief cell
Tree Number: T2.12.22
database_cross_reference: AOD:0000017267
database_cross_reference: FMA:62902
database_cross_reference: MSH:D019872
database_cross_reference: NCI:C32305
database_cross_reference: SNM:T-63070
database_cross_reference: SNMI:T-57070
database_cross_reference: SNOMEDCT_US:70935009
database_cross_reference: UWDA:62902

Hymen
type: Class
subclass of: Mucous Membrane
PMOID: PMO:00000278
Subclass_of: Mucous Membrane
Synonym: Hymen of vagina
Synonym: Hymen vaginae
Synonym: Structure of hymen
Synonym: Structure of hymen (body structure)
Synonym: Vaginal hymen
Synonym: hymen
Synonym: hymen of vagina
Synonym: hymens
Tree Number: T1.3.8.3.3
database_cross_reference: CHV:0000006395
database_cross_reference: FMA:20005
database_cross_reference: MSH:D006924
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32750
database_cross_reference: RCD:X756P
database_cross_reference: SNM:T-81400
database_cross_reference: SNMI:T-82400
database_cross_reference: SNOMEDCT_US:27907006
database_cross_reference: UWDA:20005

Intestinal Mucosa
type: Class
subclass of: Mucous Membrane
PMOID: PMO:00000279
Subclass_of: Mucous Membrane
Synonym: Intestinal mucosa
Synonym: Intestinal mucosa, NOS
Synonym: Intestinal mucous membrane
Synonym: Intestinal mucous membrane structure
Synonym: Intestinal mucous membrane structure (body structure)
Synonym: Intestinal mucous membrane, NOS
Synonym: Mucosa of intestine
Synonym: Mucosa, Intestinal
Synonym: intestinal membrane mucous
Synonym: intestinal mucosa
Tree Number: T1.3.8.3.4
database_cross_reference: AOD:0000017275
database_cross_reference: CHV:0000006857
database_cross_reference: CSP:1250-5140
database_cross_reference: FMA:15695
database_cross_reference: LCH_NW:sh88005282
database_cross_reference: MSH:D007413
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C49241
database_cross_reference: SNM:T-50130
database_cross_reference: SNMI:T-50510
database_cross_reference: SNOMEDCT_US:68534000
database_cross_reference: UWDA:15695

Paneth Cells
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000280
Subclass_of: Epithelial Cells
Synonym: Cells, Paneth
Synonym: Paneth Cell
Synonym: Paneth cell
Synonym: Paneth cell (body structure)
Synonym: Paneth cell (cell)
Synonym: paneth cell
Synonym: paneth cells
Tree Number: T2.12.23
database_cross_reference: CHV:0000022104
database_cross_reference: FMA:62897
database_cross_reference: MSH:D019879
database_cross_reference: NCI:C12593
database_cross_reference: SNM:T-64130
database_cross_reference: SNMI:T-58130
database_cross_reference: SNOMEDCT_US:84907006
database_cross_reference: UWDA:62897

Goblet Cells
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000281
Subclass_of: Epithelial Cells
Synonym: Cell, Goblet
Synonym: Cells, Goblet
Synonym: Goblet Cell
Synonym: Goblet cell
Synonym: Mucous cell
Synonym: cell goblets
Synonym: cells goblet
Synonym: goblet cell
Synonym: goblet cells
Synonym: mucous cell
Tree Number: T2.12.24
database_cross_reference: CHV:0000037527
database_cross_reference: CSP:4005-0023
database_cross_reference: FMA:13148
database_cross_reference: MSH:D020397
database_cross_reference: NCI:C12586
database_cross_reference: NCI:TCGA
database_cross_reference: UWDA:13148

Enterocytes
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000282
Subclass_of: Epithelial Cells
Synonym: Enterocyte
Synonym: enterocyte
Synonym: enterocytes
Tree Number: T2.12.25
database_cross_reference: AOD:0000017274
database_cross_reference: CHV:0000043655
database_cross_reference: FMA:62122
database_cross_reference: LNC:LP135744-3
database_cross_reference: MSH:D020895
database_cross_reference: NCI:C12585
database_cross_reference: UWDA:62122

Mouth Mucosa
type: Class
subclass of: Mucous Membrane
PMOID: PMO:00000283
Subclass_of: Mucous Membrane
Synonym: MUCOSA, ORAL
Synonym: Mouth mucosa
Synonym: Mucosa of mouth
Synonym: Mucosa of the mouth
Synonym: Mucosa, Mouth
Synonym: Mucosa, Oral
Synonym: Mucous membrane of mouth
Synonym: ORAL MUCOSA
Synonym: Oral Mucosa
Synonym: Oral mucosa
Tree Number: T1.3.8.3.5
database_cross_reference: CHV:0000008287
database_cross_reference: CHV:0000052722
database_cross_reference: CSP:2139-1486
database_cross_reference: FMA:59660
database_cross_reference: LCH:U005801
database_cross_reference: LCH_NW:sh85095245
database_cross_reference: MSH:D009061
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C77637
database_cross_reference: NCI_CDISC:SDTM-LOC
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: NCI_NICHD:C77637
database_cross_reference: RCD:X75DA
database_cross_reference: SNM:T-51030
database_cross_reference: SNMI:T-51300
database_cross_reference: SNOMEDCT_US:113277000
database_cross_reference: SNOMEDCT_US:409874000
database_cross_reference: UWDA:59660

Respiratory Mucosa
type: Class
subclass of: Mucous Membrane
PMOID: PMO:00000284
Subclass_of: Mucous Membrane
Synonym: Mucosa, Respiratory
Synonym: RESP MUCOSA
Synonym: Respiratory mucosa
Tree Number: T1.3.8.3.6
database_cross_reference: LCH_NW:sh88004529
database_cross_reference: MSH:D020545

Serous Membrane
type: Class
subclass of: Membranes
PMOID: PMO:00000289
Subclass_of: Membranes
Synonym: Membrane, Serous
Synonym: Membranes, Serous
Synonym: Serosa
Synonym: Serous Membranes
Synonym: Serous membrane
Synonym: Serous membrane structure
Synonym: Serous membrane structure (body structure)
Synonym: Serous membrane, NOS
Synonym: Tunica serosa
Synonym: Wall of serous sac
Tree Number: T1.3.8.4
database_cross_reference: AOD:0000016910
database_cross_reference: AOD:0000027643
database_cross_reference: AOD:0000027644
database_cross_reference: CHV:0000011224
database_cross_reference: CSP:0461-0833
database_cross_reference: FMA:45637
database_cross_reference: FMA:9581
database_cross_reference: MSH:D012704
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13169
database_cross_reference: NCI_NCI-GLOSS:CDR0000454933
database_cross_reference: NCI_NCI-GLOSS:CDR0000454934
database_cross_reference: SNM:T-1X120
database_cross_reference: SNMI:T-1A110
database_cross_reference: SNOMEDCT_US:75858005
database_cross_reference: UWDA:45637
database_cross_reference: UWDA:9581

Pericardium
type: Class
subclass of: Serous Membrane
PMOID: PMO:00000290
Subclass_of: Serous Membrane
Synonym: 39 PERICARDIUM
Synonym: PERICARDIUM
Synonym: Pericardial
Synonym: Pericardial sac
Synonym: Pericardial sac structure
Synonym: Pericardial sac structure (body structure)
Synonym: Pericardial structure
Synonym: Pericardial structure (body structure)
Synonym: Pericardium, NOS
Synonym: pericardial sac
Tree Number: T1.3.8.4.1
database_cross_reference: AOD:0000017167
database_cross_reference: CHV:0000009491
database_cross_reference: CSP:1390-3467
database_cross_reference: FMA:9868
database_cross_reference: FMA:9869
database_cross_reference: LCH:U003549
database_cross_reference: LCH_NW:sh85099851
database_cross_reference: MSH:D010496
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13005
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13005
database_cross_reference: NCI_NICHD:C13005
database_cross_reference: RCD:7N414
database_cross_reference: RCD:Xa0eS
database_cross_reference: SNM:T-31000
database_cross_reference: SNM:U000437
database_cross_reference: SNMI:T-39000
database_cross_reference: SNOMEDCT_US:24949005
database_cross_reference: SNOMEDCT_US:76848001
database_cross_reference: UWDA:9868
database_cross_reference: UWDA:9869

Pleura
type: Class
subclass of: Serous Membrane
PMOID: PMO:00000292
Subclass_of: Serous Membrane
Synonym: 29 PLEURA
Synonym: PLEURA
Synonym: Pleura, NOS
Synonym: Pleural
Synonym: Pleural Tissue
Synonym: Pleural membrane structure
Synonym: Pleural membrane structure (body structure)
Synonym: Pleural structure
Synonym: Pleuro-
Synonym: Wall of pleural sac
Tree Number: T1.3.8.4.3
database_cross_reference: AOD:0000017241
database_cross_reference: CHV:0000009849
database_cross_reference: CST:RES/PLRA
database_cross_reference: FMA:9583
database_cross_reference: LCH:U003722
database_cross_reference: LCH_NW:sh85103493
database_cross_reference: LNC:LA4680-0
database_cross_reference: LNC:LP124831-1
database_cross_reference: LNC:LP199939-2
database_cross_reference: LNC:MTHU040199
database_cross_reference: MSH:D010994
database_cross_reference: MTH:U002174
database_cross_reference: NCI:C12469
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12469
database_cross_reference: NCI_NCI-GLOSS:CDR0000045842
database_cross_reference: NCI_NICHD:C12469
database_cross_reference: RCD:7N800
database_cross_reference: RCD:XC0KX
database_cross_reference: RCD:Xa0cX
database_cross_reference: SNM:T-29000
database_cross_reference: SNM:U000435
database_cross_reference: SNMI:T-29000
database_cross_reference: SNOMEDCT_US:3120008
database_cross_reference: UWDA:9583

Muscles
type: Class
subclass of: Tissues
PMOID: PMO:00000293
Subclass_of: Tissues
Synonym: MUSCLE
Synonym: Muscle
Synonym: Muscle (organ)
Synonym: Muscle Tissue
Synonym: Muscle Tissues
Synonym: Muscle organ
Synonym: Muscle tissue
Synonym: Muscle tissue (body structure)
Synonym: Muscle, NOS
Synonym: Muscles, NOS
Tree Number: T1.3.9
database_cross_reference: AOD:0000002457
database_cross_reference: AOD:0000027635
database_cross_reference: CHV:0000008358
database_cross_reference: CHV:0000037494
database_cross_reference: CSP:1979-3864
database_cross_reference: DRUGBANK:DB00825
database_cross_reference: DRUGBANK:DB01744
database_cross_reference: DRUGBANK:DB09543
database_cross_reference: FMA:30316
database_cross_reference: FMA:5022
database_cross_reference: LCH:U003065
database_cross_reference: LCH:U006531
database_cross_reference: LCH_NW:sh85088687
database_cross_reference: LNC:LP199993-9
database_cross_reference: LNC:LP20705-7
database_cross_reference: LNC:LP32940-6
database_cross_reference: LNC:LP33444-8
database_cross_reference: LNC:MTHU016812
database_cross_reference: MSH:D009132
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12435
database_cross_reference: NCI:C13056
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13056
database_cross_reference: NCI_NICHD:C13056
database_cross_reference: OMIM:MTHU023760
database_cross_reference: PSY:32580
database_cross_reference: RCD:X74sw
database_cross_reference: SNM:T-13001
database_cross_reference: SNMI:T-13000
database_cross_reference: SNMI:T-13001
database_cross_reference: SNMI:T-13009
database_cross_reference: SNOMEDCT_US:71616004
database_cross_reference: SNOMEDCT_US:79984008
database_cross_reference: SNOMEDCT_US:91727004
database_cross_reference: SNOMEDCT_VET:91727004
database_cross_reference: UWDA:30316
database_cross_reference: UWDA:5022

Muscle, Smooth
type: Class
subclass of: Muscles
PMOID: PMO:00000294
Subclass_of: Muscles
Synonym: 1A5 SMOOTH MUSCLE
Synonym: Involuntary Muscle
Synonym: Involuntary Muscles
Synonym: Involuntary muscle
Synonym: MUSCLE, SMOOTH
Synonym: Muscle, Involuntary
Synonym: Muscles, Involuntary
Synonym: Muscles, Smooth
Synonym: Non-striated muscle
Synonym: Portion of smooth muscle tissue
Tree Number: T1.3.9.1
database_cross_reference: AOD:0000016905
database_cross_reference: AOD:0000027640
database_cross_reference: CHV:0000008357
database_cross_reference: CHV:0000056700
database_cross_reference: CSP:1982-1959
database_cross_reference: FMA:14070
database_cross_reference: LCH_NW:sh85123706
database_cross_reference: LNC:LP16762-4
database_cross_reference: MSH:D009130
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12437
database_cross_reference: NCI_CDISC:SDTM-SPECTYPE
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: SNM:T-1X300
database_cross_reference: SNM:U000423
database_cross_reference: SNMI:T-1A500
database_cross_reference: SNOMEDCT_US:122447002
database_cross_reference: SNOMEDCT_US:39822001
database_cross_reference: UWDA:14070

Muscle, Smooth, Vascular
type: Class
subclass of: Muscle, Smooth
PMOID: PMO:00000295
Subclass_of: Muscle, Smooth
Synonym: Muscle, Vascular Smooth
Synonym: Muscles, Vascular Smooth
Synonym: Smooth Muscle, Vascular
Synonym: Smooth Muscles, Vascular
Synonym: Vascular Smooth Muscle
Synonym: Vascular Smooth Muscles
Synonym: Vascular smooth muscle
Synonym: vascular smooth muscle
Tree Number: T1.3.9.1.1
database_cross_reference: CSP:0581-4865
database_cross_reference: LCH:U004900
database_cross_reference: LCH_NW:sh85142361
database_cross_reference: MSH:D009131

Myometrium
type: Class
subclass of: Muscle, Smooth
PMOID: PMO:00000296
Subclass_of: Muscle, Smooth
Synonym: 836 MYOMETRIUM
Synonym: MYOMETRIUM
Synonym: Muscle, Uterine
Synonym: Muscles, Uterine
Synonym: Myometrial structure
Synonym: Myometrial structure (body structure)
Synonym: Myometrium, NOS
Synonym: Tunica muscularis (Myometrium)
Synonym: Tunica muscularis uteri
Synonym: Uterine Muscle
Tree Number: T1.3.9.1.2
database_cross_reference: AOD:0000017406
database_cross_reference: CHV:0000008436
database_cross_reference: CSP:2587-5224
database_cross_reference: FMA:17743
database_cross_reference: LCH:U003100
database_cross_reference: LCH_NW:sh85089265
database_cross_reference: MSH:D009215
database_cross_reference: MTH:U002096
database_cross_reference: NCI:C12314
database_cross_reference: NCI_CDISC:C12314
database_cross_reference: NCI_NCI-GLOSS:CDR0000046280
database_cross_reference: NCI_NICHD:C12314
database_cross_reference: RCD:Xa1E5
database_cross_reference: SNM:T-85000
database_cross_reference: SNM:U000485
database_cross_reference: SNMI:T-83600
database_cross_reference: SNOMEDCT_US:27232003
database_cross_reference: UWDA:17743

Muscle, Striated
type: Class
subclass of: Muscles
PMOID: PMO:00000297
Subclass_of: Muscles
Synonym: MUSCLE STRIATED
Synonym: Muscles, Striated
Synonym: STRIATED MUSCLE TISSUE
Synonym: Striated Muscle
Synonym: Striated Muscle Tissue
Synonym: Striated Muscles
Synonym: Striated muscle
Synonym: Striated muscle (tissue)
Synonym: Striated muscle (tissue) (body structure)
Synonym: Striated muscle system
Tree Number: T1.3.9.2
database_cross_reference: AOD:0000016904
database_cross_reference: CSP:1982-2542
database_cross_reference: FMA:67905
database_cross_reference: LCH_NW:sh85128719
database_cross_reference: LNC:LP16768-1
database_cross_reference: MSH:D054792
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12436
database_cross_reference: NCI_CDISC:C12436
database_cross_reference: SNMI:T-13000
database_cross_reference: SNMI:T-13001
database_cross_reference: SNOMEDCT_US:118252003
database_cross_reference: SNOMEDCT_US:127954009
database_cross_reference: SNOMEDCT_US:71616004
database_cross_reference: SNOMEDCT_US:79984008
database_cross_reference: UWDA:67905

Myocardium
type: Class
subclass of: Muscle, Striated
PMOID: PMO:00000298
Subclass_of: Muscle, Striated
Synonym: CARDIAC MUSCLE TISSUE
Synonym: Cardiac Muscle
Synonym: Cardiac Muscles
Synonym: Cardiac muscle
Synonym: Cardiac muscle (tissue)
Synonym: Cardiac muscle (tissue) (body structure)
Synonym: Cardiac muscle tissue
Synonym: Heart Muscle
Synonym: Heart Muscles
Synonym: Heart muscle
Tree Number: T1.3.9.2.1
database_cross_reference: AOD:0000017170
database_cross_reference: AOD:0000027719
database_cross_reference: CHV:0000008426
database_cross_reference: CHV:0000056701
database_cross_reference: CSP:1390-2774
database_cross_reference: FMA:14068
database_cross_reference: FMA:9462
database_cross_reference: LCH_NW:sh85059694
database_cross_reference: LNC:LP101987-8
database_cross_reference: LNC:LP16727-7
database_cross_reference: LNC:MTHU050170
database_cross_reference: MSH:D009206
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12371
database_cross_reference: NCI_CDISC:C12371
database_cross_reference: PSY:32830
database_cross_reference: RCD:XC0Is
database_cross_reference: SNM:T-33010
database_cross_reference: SNMI:T-32020
database_cross_reference: SNOMEDCT_US:122448007
database_cross_reference: SNOMEDCT_US:74281007
database_cross_reference: UWDA:14068
database_cross_reference: UWDA:9462

Myocytes, Cardiac
type: Class
subclass of: Muscle Cells
PMOID: PMO:00000299
Subclass_of: Muscle Cells
Synonym: Cardiac Muscle Cell
Synonym: Cardiac Muscle Cells
Synonym: Cardiac Myocyte
Synonym: Cardiac Myocytes
Synonym: Cardiac muscle cell
Synonym: Cardiac muscle fiber
Synonym: Cardiac myocyte
Synonym: Cardiac myocyte (cell)
Synonym: Cardiac myocyte, NOS
Synonym: Cardiac myofiber
Tree Number: T2.19.2
database_cross_reference: AOD:0000017168
database_cross_reference: CHV:0000021955
database_cross_reference: CSP:4009-0006
database_cross_reference: FMA:14067
database_cross_reference: FMA:260659
database_cross_reference: MSH:D032383
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13002
database_cross_reference: SNMI:T-32030
database_cross_reference: SNOMEDCT_US:86441007
database_cross_reference: SNOMEDCT_VET:86441007
database_cross_reference: UWDA:14067

Myoblasts, Cardiac
type: Class
subclass of: Myoblasts
PMOID: PMO:00000300
Subclass_of: Myoblasts
Synonym: Cardiac Myoblast
Synonym: Cardiac Myoblasts
Synonym: Cardiac myoblast
Synonym: Myoblast, Cardiac
Synonym: cardiac myoblast
Synonym: cardiac myoblasts
Tree Number: T2.34.4.1
database_cross_reference: CHV:0000054911
database_cross_reference: FMA:84797
database_cross_reference: MSH:D032386

Myofibrils
type: Class
subclass of: Muscle, Striated
subclass of: Myocytes, Cardiac
subclass of: Muscle Fibers, Skeletal
PMOID: PMO:00000301
Subclass_of: Muscle Fibers, Skeletal
Subclass_of: Muscle, Striated
Subclass_of: Myocytes, Cardiac
Synonym: Myofibril
Synonym: Myofibril (substance)
Synonym: Myofibril, NOS
Synonym: Myofibrilla
Synonym: fibers muscle striated
Synonym: myofibril
Synonym: striated muscle fiber
Synonym: striated muscle fibre
Tree Number: T1.3.9.2.2
Tree Number: T2.19.1.1
Tree Number: T2.19.2.1
database_cross_reference: AOD:0000016900
database_cross_reference: CHV:0000008431
database_cross_reference: CSP:1980-8848
database_cross_reference: FMA:67718
database_cross_reference: GO:GO:0030016
database_cross_reference: MSH:D009210
database_cross_reference: SNMI:T-13020
database_cross_reference: SNOMEDCT_US:105583006
database_cross_reference: UWDA:67718

Sarcomeres
type: Class
subclass of: Myofibrils
PMOID: PMO:00000302
Subclass_of: Myofibrils
Synonym: Sarcomere
Synonym: sarcomere
Synonym: sarcomeres
Tree Number: T2.19.1.1.1
Tree Number: T2.19.2.1.1
database_cross_reference: AOD:0000016902
database_cross_reference: CHV:0000011050
database_cross_reference: CSP:1975-6437
database_cross_reference: FMA:67895
database_cross_reference: GO:GO:0030017
database_cross_reference: MSH:D012518
database_cross_reference: NCI:C87821
database_cross_reference: UWDA:67895

Muscle, Skeletal
type: Class
subclass of: Muscle, Striated
PMOID: PMO:00000303
Subclass_of: Muscle, Striated
Synonym: MUSCLE SKELETAL
Synonym: MUSCLE VOLUNTARY
Synonym: MUSCLE, SKELETAL
Synonym: Muscle, Voluntary
Synonym: Muscles, Skeletal
Synonym: Muscles, Voluntary
Synonym: SKELETAL MUSCLE TISSUE
Synonym: Skeletal Muscle
Synonym: Skeletal Muscle Tissue
Synonym: Skeletal Muscles
Tree Number: T1.3.9.2.3
database_cross_reference: AOD:0000017042
database_cross_reference: AOD:0000027668
database_cross_reference: CHV:0000024926
database_cross_reference: CSP:1982-2542
database_cross_reference: FMA:14069
database_cross_reference: MSH:D018482
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13050
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13050
database_cross_reference: NCI_CDISC:SDTM-SPECTYPE
database_cross_reference: NCI_CDISC:SEND-SPEC
database_cross_reference: RCD:X74sw
database_cross_reference: RCD:Xa1Pu
database_cross_reference: SNM:T-13000
database_cross_reference: SNMI:T-13000
database_cross_reference: SNOMEDCT_US:127954009
database_cross_reference: SNOMEDCT_US:79984008
database_cross_reference: UWDA:14069

Muscle Fibers, Skeletal
type: Class
subclass of: Muscle Cells
PMOID: PMO:00000306
Subclass_of: Muscle Cells
Synonym: Fiber, Skeletal Muscle
Synonym: Fibers, Skeletal Muscle
Synonym: Muscle Fiber, Skeletal
Synonym: Myocyte, Skeletal
Synonym: Myocytes, Skeletal
Synonym: Myocytus striatus
Synonym: Myotube
Synonym: Myotubes
Synonym: Rhabdomyocyte
Synonym: Skeletal Fiber
Tree Number: T2.19.1
database_cross_reference: CHV:0000021683
database_cross_reference: FMA:9727
database_cross_reference: MSH:D018485
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13000
database_cross_reference: NCI:C33558
database_cross_reference: NCI:C48687
database_cross_reference: SNM:T-13010
database_cross_reference: SNMI:T-13010
database_cross_reference: SNOMEDCT_US:80985008
database_cross_reference: UWDA:9727

Muscle Fibers, Fast-Twitch
type: Class
subclass of: Muscle Fibers, Skeletal
PMOID: PMO:00000308
Subclass_of: Muscle Fibers, Skeletal
Synonym: Fast-Twitch Muscle Fiber
Synonym: Fast-Twitch Muscle Fibers
Synonym: Fast-twitch muscle fiber
Synonym: Fiber, Fast-Twitch Muscle
Synonym: Fibers, Fast-Twitch Muscle
Synonym: Muscle Fiber, Fast-Twitch
Synonym: Muscle Fibers, Fast Twitch
Synonym: Muscle Fibers, Type II
Synonym: Skeletal muscle fiber, type II
Synonym: Skeletal muscle fiber, type II (cell structure)
Tree Number: T2.19.1.2
database_cross_reference: FMA:84414
database_cross_reference: MSH:D018656
database_cross_reference: NCI:C12613
database_cross_reference: SNM:T-13012
database_cross_reference: SNMI:T-13012
database_cross_reference: SNOMEDCT_US:87812003

Muscle Fibers, Slow-Twitch
type: Class
subclass of: Muscle Fibers, Skeletal
PMOID: PMO:00000309
Subclass_of: Muscle Fibers, Skeletal
Synonym: Fiber, Slow-Twitch Muscle
Synonym: Fibers, Slow-Twitch Muscle
Synonym: Muscle Fiber, Slow-Twitch
Synonym: Muscle Fibers, Slow Twitch
Synonym: Muscle Fibers, Type I
Synonym: Skeletal muscle fiber, type I
Synonym: Skeletal muscle fiber, type I (cell structure)
Synonym: Skeletal muscle fiber, type I (cell)
Synonym: Slow-Twitch Muscle Fiber
Synonym: Slow-Twitch Muscle Fibers
Tree Number: T2.19.1.3
database_cross_reference: CHV:0000025014
database_cross_reference: FMA:84413
database_cross_reference: MSH:D018657
database_cross_reference: NCI:C12614
database_cross_reference: SNM:T-13011
database_cross_reference: SNMI:T-13011
database_cross_reference: SNOMEDCT_US:36499009

Nerve Tissue
type: Class
subclass of: Tissues
PMOID: PMO:00000310
Subclass_of: Tissues
Synonym: A02-A03 NEURONS, TRACTS AND FIBERS
Synonym: NERVE
Synonym: NEURONS, TRACTS AND FIBERS
Synonym: Nerve Tissues
Synonym: Nerve tissue
Synonym: Nervous Tissue
Synonym: Nervous Tissues
Synonym: Nervous tissue
Synonym: Nervous tissue (body structure)
Synonym: Neural tissue
Tree Number: T1.3.10
database_cross_reference: AOD:0000017763
database_cross_reference: CHV:0000008603
database_cross_reference: FMA:9642
database_cross_reference: LCH:U003163
database_cross_reference: LCH_NW:sh85090897
database_cross_reference: MSH:D009417
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13052
database_cross_reference: NCI_CDISC:C13052
database_cross_reference: PSY:33460
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:T-A0200
database_cross_reference: SNMI:T-A0305
database_cross_reference: SNOMEDCT_US:110657001
database_cross_reference: SNOMEDCT_US:91728009
database_cross_reference: UWDA:9642

Ependyma
type: Class
subclass of: Nerve Tissue
PMOID: PMO:00000311
Subclass_of: Nerve Tissue
Synonym: Ependyma (body structure)
Synonym: Ependyma of neuraxis
Synonym: Ependyma, NOS
Synonym: Ependymal Tissue
Synonym: Ependymas
Synonym: Lamina epithelialis
Synonym: ependyma
Tree Number: T1.3.10.1
database_cross_reference: CHV:0000004533
database_cross_reference: CSP:0476-6742
database_cross_reference: FMA:242791
database_cross_reference: LCH:U001622
database_cross_reference: LCH_NW:sh85044249
database_cross_reference: MSH:D004805
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13078
database_cross_reference: NCI_NCI-GLOSS:CDR0000540759
database_cross_reference: NEU:1856
database_cross_reference: PSY:17650
database_cross_reference: SNM:T-X1610
database_cross_reference: SNMI:T-A1610
database_cross_reference: SNOMEDCT_US:12766003

Myelin Sheath
type: Class
subclass of: Nerve Tissue
subclass of: Cell Membrane Structures
subclass of: Oligodendroglia
subclass of: Schwann Cells
subclass of: Nerve Fibers, Myelinated
PMOID: PMO:00000312
Subclass_of: Cell Membrane Structures
Subclass_of: Nerve Fibers, Myelinated
Subclass_of: Nerve Tissue
Subclass_of: Oligodendroglia
Subclass_of: Schwann Cells
Synonym: Myelin
Synonym: Myelin Sheaths
Synonym: Myelin sheath
Synonym: Myelin sheath structure
Synonym: Myelin sheath structure (body structure)
Synonym: Myelin sheath structure (cell structure)
Synonym: Myelin sheath, NOS
Synonym: Myelinated
Synonym: Sheath, Myelin
Synonym: Sheaths, Myelin
Tree Number: T1.3.10.2
Tree Number: T1.4.1.6.3
Tree Number: T2.22.3.1
Tree Number: T2.22.4.1
Tree Number: T2.23.6.5.1
Tree Number: T2.23.7.1
Tree Number: T2.8.1.6.3
database_cross_reference: AOD:0000017766
database_cross_reference: AOD:0000028042
database_cross_reference: CHV:0000008403
database_cross_reference: FMA:62983
database_cross_reference: GO:GO:0043209
database_cross_reference: LCH:U003087
database_cross_reference: LCH_NW:sh85089215
database_cross_reference: MSH:D009186
database_cross_reference: MTH:U002094
database_cross_reference: NCI:C13261
database_cross_reference: NCI_NCI-GLOSS:CDR0000046276
database_cross_reference: PSY:32780
database_cross_reference: SNM:T-X0360
database_cross_reference: SNMI:T-A0360
database_cross_reference: SNOMEDCT_US:23879005
database_cross_reference: UWDA:62983

Neurilemma
type: Class
subclass of: Myelin Sheath
PMOID: PMO:00000313
Subclass_of: Myelin Sheath
Synonym: Neurilemma (body structure)
Synonym: Neurilemma (cell structure)
Synonym: Neurolemma
Synonym: Schwann Sheath
Synonym: Schwann sheath
Synonym: Schwann's membrane
Synonym: Sheath of Schwann
Synonym: Sheath, Schwann
Synonym: neurilemma
Synonym: neurolemma
Tree Number: T1.3.10.2.1
Tree Number: T2.22.4.1.1
database_cross_reference: AOD:0000017767
database_cross_reference: AOD:0000028043
database_cross_reference: AOD:0000028044
database_cross_reference: AOD:0000028045
database_cross_reference: CHV:0000008623
database_cross_reference: CSP:2047-3242
database_cross_reference: FMA:62976
database_cross_reference: MSH:D009441
database_cross_reference: NCI:C33544
database_cross_reference: SNM:T-X0530
database_cross_reference: SNMI:T-A0530
database_cross_reference: SNOMEDCT_US:71481009
database_cross_reference: UWDA:62976

Ranvier's Nodes
type: Class
subclass of: Myelin Sheath
subclass of: Cell Membrane Structures
PMOID: PMO:00000314
Subclass_of: Cell Membrane Structures
Subclass_of: Myelin Sheath
Tree Number: T1.3.10.2.2
Tree Number: T1.4.1.6.5
Tree Number: T2.22.4.1.2
Tree Number: T2.23.7.1.1
Tree Number: T2.8.1.6.5

Organoids
type: Class
subclass of: Tissues
PMOID: PMO:00000315
Subclass_of: Tissues
Synonym: Organoid
Synonym: organoid
Synonym: organoids
Tree Number: T1.3.11
database_cross_reference: CHV:0000009027
database_cross_reference: MSH:D009940

Surgically-Created Structures
type: Class
subclass of: Tissues
PMOID: PMO:00000316
Subclass_of: Tissues
Synonym: STRUCTURE SURG CREATED
Synonym: STRUCTURES SURG CREATED
Synonym: SURG CREATED STRUCTURE
Synonym: SURG CREATED STRUCTURES
Synonym: Structure, Surgically Created
Synonym: Structure, Surgically-Created
Synonym: Structures, Surgically Created
Synonym: Structures, Surgically-Created
Synonym: Surgically Created Structure
Synonym: Surgically Created Structures
Tree Number: T1.3.12
database_cross_reference: MSH:D019738
database_cross_reference: NCI:C25761

Surgical Flaps
type: Class
subclass of: Surgically-Created Structures
PMOID: PMO:00000317
Subclass_of: Surgically-Created Structures
Synonym: FLAP SURG
Synonym: FLAPS SURG
Synonym: Flap
Synonym: Flap (attribute)
Synonym: Flap (substance)
Synonym: Flap Graft
Synonym: Flap Transplant
Synonym: Flap, Surgical
Synonym: Flaps
Synonym: Flaps (substance)
Tree Number: T1.3.12.1
database_cross_reference: AOD:0000008149
database_cross_reference: CHV:0000011926
database_cross_reference: MSH:D013524
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C127814
database_cross_reference: RCD:X75U0
database_cross_reference: RCD:X79YU
database_cross_reference: RCD:Zw050
database_cross_reference: RCDSY:Zw050
database_cross_reference: SNOMEDCT_US:246343008
database_cross_reference: SNOMEDCT_US:256683004
database_cross_reference: SNOMEDCT_US:316918004

Free Tissue Flaps
type: Class
subclass of: Surgical Flaps
PMOID: PMO:00000318
Subclass_of: Surgical Flaps
Synonym: Flap, Free
Synonym: Flap, Free Tissue
Synonym: Flap, Microsurgical Free
Synonym: Flaps, Free
Synonym: Flaps, Free Tissue
Synonym: Flaps, Microsurgical Free
Synonym: Free Flap
Synonym: Free Flap, Microsurgical
Synonym: Free Flaps
Synonym: Free Flaps, Microsurgical
Tree Number: T1.3.12.1.1
database_cross_reference: CHV:0000034769
database_cross_reference: MSH:D058752
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X90EK
database_cross_reference: SNOMEDCT_US:261238005

Perforator Flap
type: Class
subclass of: Surgical Flaps
PMOID: PMO:00000319
Subclass_of: Surgical Flaps
Synonym: Flap, Perforator
Synonym: Flaps, Perforator
Synonym: Perforator Flaps
Tree Number: T1.3.12.1.2
database_cross_reference: MSH:D061525

Myocutaneous Flap
type: Class
subclass of: Surgical Flaps
PMOID: PMO:00000320
Subclass_of: Surgical Flaps
Synonym: Flap, Musculocutaneous
Synonym: Flap, Myocutaneous
Synonym: Flaps, Musculocutaneous
Synonym: Flaps, Myocutaneous
Synonym: Musculocutaneous Flap
Synonym: Musculocutaneous Flaps
Synonym: Myocutaneous
Synonym: Myocutaneous Flaps
Synonym: Myocutaneous flap
Synonym: Myocutaneous flap (substance)
Tree Number: T1.3.12.1.3
database_cross_reference: CHV:0000035930
database_cross_reference: MSH:D064827
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:X90B9
database_cross_reference: SNOMEDCT_US:261138003

Urinary Reservoirs, Continent
type: Class
subclass of: Surgically-Created Structures
PMOID: PMO:00000321
Subclass_of: Surgically-Created Structures
Synonym: Colonic Urinary Reservoir
Synonym: Colonic Urinary Reservoirs
Synonym: Continent Urinary Reservoir
Synonym: Continent Urinary Reservoirs
Synonym: Reservoir, Colonic Urinary
Synonym: Reservoir, Continent Urinary
Synonym: Reservoirs, Colonic Urinary
Synonym: Reservoirs, Continent Urinary
Synonym: Urinary Reservoir, Colonic
Synonym: Urinary Reservoir, Continent
Tree Number: T1.3.12.2
database_cross_reference: MSH:D016476
database_cross_reference: MTH:NOCODE

Skeletal Muscle Ventricle
type: Class
subclass of: Surgically-Created Structures
PMOID: PMO:00000322
Subclass_of: Surgically-Created Structures
Tree Number: T1.3.12.3

Colonic Pouches
type: Class
subclass of: Surgically-Created Structures
PMOID: PMO:00000323
Subclass_of: Surgically-Created Structures
Synonym: Colonic Pouche
Synonym: Pelvic Pouches
Synonym: Pouche, Colonic
Synonym: Pouches, Colonic
Synonym: Pouches, Pelvic
Tree Number: T1.3.12.4
database_cross_reference: MSH:D039021

Surgical Stomas
type: Class
subclass of: Surgically-Created Structures
PMOID: PMO:00000324
Subclass_of: Surgically-Created Structures
Synonym: Stoma
Synonym: Stoma (body structure)
Synonym: Stoma (morphologic abnormality)
Synonym: Stoma site
Synonym: Stoma site (morphologic abnormality)
Synonym: Stoma site, NOS
Synonym: Stoma, NOS
Synonym: Stoma, Surgical
Synonym: Stomas
Synonym: Stomas, Surgical
Tree Number: T1.3.12.5
database_cross_reference: CHV:0000029568
database_cross_reference: LCH_NW:sh85128277
database_cross_reference: MEDLINEPLUS:3038
database_cross_reference: MSH:D054047
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13345
database_cross_reference: NCI_NCI-GLOSS:CDR0000045104
database_cross_reference: RCD:X75Io
database_cross_reference: SNM:M-18800
database_cross_reference: SNM:NOCODE
database_cross_reference: SNMI:M-18800
database_cross_reference: SNOMEDCT_US:245857005
database_cross_reference: SNOMEDCT_US:91241007

Cell Component
type: Class
subclass of: Anatomical Structure
PMOID: PMO:00000325
Subclass_of: Anatomical Structure
Synonym: Cell Components
Synonym: Cell Structure
Synonym: Cell component
Synonym: Cellular AND/OR subcellular structure
Synonym: Cellular AND/OR subcellular structure (body structure)
Synonym: Cellular Structure
Synonym: Cellular Structures
Synonym: Cellular structure
Synonym: Cellular structures
Synonym: Component, Cell
Tree Number: T1.4
database_cross_reference: AOD:0000016720
database_cross_reference: CHV:0000025102
database_cross_reference: CSP:0592-6172
database_cross_reference: FMA:86454
database_cross_reference: MSH:D022082
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C14135
database_cross_reference: RCD:Xa0bB
database_cross_reference: SNOMEDCT_US:108351002

Cell Membrane
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000326
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Cell Membranes
Synonym: Cell membrane
Synonym: Cell membrane (body structure)
Synonym: Cell membrane (cell structure)
Synonym: Cell membrane, NOS
Synonym: Cell membranes
Synonym: Cellular membrane
Synonym: Cytoplasmic Membrane
Synonym: Cytoplasmic Membranes
Synonym: Cytoplasmic membrane
Tree Number: T1.4.1
Tree Number: T2.8.1
database_cross_reference: AOD:0000016761
database_cross_reference: AOD:0000027601
database_cross_reference: AOD:0000027603
database_cross_reference: CHV:0000002592
database_cross_reference: CSP:0592-9918
database_cross_reference: FMA:63841
database_cross_reference: GO:GO:0005886
database_cross_reference: GO:GO:0009280
database_cross_reference: LCH:U000871
database_cross_reference: LCH_NW:sh85021654
database_cross_reference: MSH:D002462
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13735
database_cross_reference: NCI_NCI-GLOSS:CDR0000044615
database_cross_reference: SNMI:T-E0200
database_cross_reference: SNOMEDCT_US:53982002
database_cross_reference: UWDA:63841

Erythrocyte Membrane
type: Class
subclass of: Cell Membrane
subclass of: Erythrocytes
PMOID: PMO:00000327
Subclass_of: Cell Membrane
Subclass_of: Erythrocytes
Synonym: Cytoskeleton, Erythrocyte
Synonym: Cytoskeletons, Erythrocyte
Synonym: Erythrocyte Cytoskeleton
Synonym: Erythrocyte Cytoskeletons
Synonym: Erythrocyte Membranes
Synonym: Erythrocyte membranes
Synonym: Membrane, Erythrocyte
Synonym: Membranes, Erythrocyte
Synonym: erythrocyte membrane
Synonym: erythrocytes membrane
Tree Number: T1.4.1.1
Tree Number: T2.4.2.1
Tree Number: T2.8.1.1
database_cross_reference: CHV:0000004626
database_cross_reference: CSP:1831-7116
database_cross_reference: LCH_NW:sh89006625
database_cross_reference: MSH:D004910

Intracellular Membranes
type: Class
subclass of: Cell Membrane
subclass of: Subcellular Fractions
PMOID: PMO:00000328
Subclass_of: Cell Membrane
Subclass_of: Subcellular Fractions
Synonym: Intracellular Membrane
Synonym: Intracellular membrane
Synonym: Membrane, Intracellular
Synonym: Membranes, Intracellular
Synonym: Organelle wall
Synonym: Wall of organelle
Synonym: intracellular membrane
Tree Number: T1.4.1.2
Tree Number: T1.4.6.3
Tree Number: T2.8.1.2
Tree Number: T2.8.6.3
database_cross_reference: CSP:0596-3632
database_cross_reference: FMA:85548
database_cross_reference: GO:GO:0031090
database_cross_reference: MSH:D007425
database_cross_reference: NCI:C32876

Nuclear Envelope
type: Class
subclass of: Intracellular Membranes
subclass of: Cell Membrane Structures
PMOID: PMO:00000329
Subclass_of: Cell Membrane Structures
Subclass_of: Intracellular Membranes
Synonym: Envelope, Nuclear
Synonym: Envelopes, Nuclear
Synonym: Karyotheca
Synonym: Membrane, Nuclear
Synonym: Membranes, Nuclear
Synonym: Nuclear Envelopes
Synonym: Nuclear Membrane
Synonym: Nuclear Membranes
Synonym: Nuclear envelope
Synonym: Nuclear envelope (body structure)
Tree Number: T1.4.1.2.1
Tree Number: T1.4.1.6.4
Tree Number: T1.4.6.3.1
Tree Number: T2.8.1.2.1
Tree Number: T2.8.1.6.4
Tree Number: T2.8.6.3.1
database_cross_reference: AOD:0000016772
database_cross_reference: AOD:0000027605
database_cross_reference: CSP:0597-2997
database_cross_reference: FMA:63888
database_cross_reference: GO:GO:0005635
database_cross_reference: GO:GO:0031965
database_cross_reference: LCH:U003277
database_cross_reference: LCH_NW:sh85093016
database_cross_reference: MSH:D009685
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13265
database_cross_reference: SNM:T-YX050
database_cross_reference: SNMI:T-E0110
database_cross_reference: SNOMEDCT_US:49842008
database_cross_reference: UWDA:63888

Mitochondrial Membranes
type: Class
subclass of: Intracellular Membranes
PMOID: PMO:00000330
Subclass_of: Intracellular Membranes
Synonym: Membrana mitochondrialis
Synonym: Membrane of mitochondrion
Synonym: Membrane, Mitochondrial
Synonym: Membranes, Mitochondrial
Synonym: Mitochondrial Membrane
Synonym: Mitochondrial membrane
Synonym: Mitochondrial membrane (body structure)
Synonym: Mitochondrial membrane (cell structure)
Synonym: Mitochondrial membranes
Synonym: Mitochondrion membrane
Tree Number: T1.4.1.2.2
Tree Number: T1.4.6.3.2
Tree Number: T2.8.1.2.2
Tree Number: T2.8.6.3.2
database_cross_reference: CSP:0597-1124
database_cross_reference: FMA:66861
database_cross_reference: GO:GO:0031966
database_cross_reference: LCH_NW:sh85086281
database_cross_reference: MSH:D051336
database_cross_reference: NCI:C25937
database_cross_reference: SNOMEDCT_US:312240004
database_cross_reference: UWDA:66861

Sarcolemma
type: Class
subclass of: Cell Membrane
PMOID: PMO:00000331
Subclass_of: Cell Membrane
Synonym: Plasma membrane of muscle cell
Synonym: Sarcolemma structure
Synonym: Sarcolemma structure (body structure)
Synonym: Sarcolemma structure (cell structure)
Synonym: Sarcolemmas
Synonym: sarcolemma
Tree Number: T1.4.1.3
Tree Number: T2.8.1.3
database_cross_reference: AOD:0000016898
database_cross_reference: CSP:1981-5012
database_cross_reference: FMA:62025
database_cross_reference: GO:GO:0042383
database_cross_reference: LCH:U004212
database_cross_reference: LCH_NW:sh85117503
database_cross_reference: MSH:D012508
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33512
database_cross_reference: SNMI:T-13008
database_cross_reference: SNOMEDCT_US:91740009
database_cross_reference: UWDA:62025

Synaptic Membranes
type: Class
subclass of: Cell Membrane
PMOID: PMO:00000332
Subclass_of: Cell Membrane
Synonym: Membrane, Synaptic
Synonym: Membranes, Synaptic
Synonym: Synaptic Membrane
Synonym: Synaptic membrane
Synonym: Synaptic membrane (body structure)
Synonym: Synaptic membrane (cell structure)
Synonym: synaptic membrane
Tree Number: T1.4.1.4
Tree Number: T2.8.1.4
database_cross_reference: GO:GO:0097060
database_cross_reference: MSH:D013570
database_cross_reference: SNMI:T-A0382
database_cross_reference: SNOMEDCT_US:81881007

Purple Membrane
type: Class
subclass of: Cell Membrane
PMOID: PMO:00000333
Subclass_of: Cell Membrane
Synonym: Membrane, Purple
Synonym: Membranes, Purple
Synonym: Purple Membranes
Synonym: bacterial purple membrane
Tree Number: T1.4.1.5
Tree Number: T2.8.1.5
database_cross_reference: CSP:2328-3889
database_cross_reference: MSH:D018717

Cell Membrane Structures
type: Class
subclass of: Cell Membrane
PMOID: PMO:00000334
Subclass_of: Cell Membrane
Synonym: Cell Membrane Structure
Synonym: Cell membrane structure
Synonym: Cell membrane structure (body structure)
Synonym: Cell membrane structure (cell structure)
Synonym: Membrane Structure, Cell
Synonym: Membrane Structures, Cell
Synonym: Structure, Cell Membrane
Synonym: Structures, Cell Membrane
Synonym: cell membrane structure
Synonym: cell membrane structures
Tree Number: T1.4.1.6
Tree Number: T2.8.1.6
database_cross_reference: CHV:0000052266
database_cross_reference: MSH:D021961
database_cross_reference: SNOMEDCT_US:312241000

Coated Pits, Cell-Membrane
type: Class
subclass of: Cell Membrane Structures
PMOID: PMO:00000335
Subclass_of: Cell Membrane Structures
Synonym: Bristle Coated Pits
Synonym: Bristle-Coated Pit
Synonym: Bristle-Coated Pits
Synonym: COATED PITS
Synonym: Cell Membrane Coated Pits
Synonym: Cell-Membrane Coated Pit
Synonym: Cell-Membrane Coated Pits
Synonym: Coated Pit
Synonym: Coated Pit, Cell-Membrane
Synonym: Coated Pits, Cell Membrane
Tree Number: T1.4.1.6.1
Tree Number: T2.8.1.6.1
database_cross_reference: CSP:2446-7000
database_cross_reference: CSP:4000-0175
database_cross_reference: MSH:D003034
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13366

Intercellular Junctions
type: Class
subclass of: Cell Membrane Structures
PMOID: PMO:00000337
Subclass_of: Cell Membrane Structures
Tree Number: T1.4.1.6.2
Tree Number: T2.8.1.6.2

Presynaptic Terminals
type: Class
subclass of: Axons
PMOID: PMO:00000344
Subclass_of: Axons
Synonym: Axon Terminal
Synonym: Axon Terminals
Synonym: Axon terminal
Synonym: Bouton terminal
Synonym: Bouton terminaux
Synonym: Bouton, Synaptic
Synonym: Boutons, Synaptic
Synonym: Ending, Presynaptic Nerve
Synonym: Endings, Presynaptic Nerve
Synonym: Nerve Ending, Presynaptic
Tree Number: T2.23.3.2
Tree Number: T2.23.6.3.3
database_cross_reference: CHV:0000020846
database_cross_reference: FMA:61813
database_cross_reference: GO:GO:0043195
database_cross_reference: MSH:D017729
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33398
database_cross_reference: UWDA:61813

Glycocalyx
type: Class
subclass of: Cell Membrane Structures
PMOID: PMO:00000352
Subclass_of: Cell Membrane Structures
Synonym: Cell Coat
Synonym: Cell Coats
Synonym: Cell coat
Synonym: Coat, Cell
Synonym: Coats, Cell
Synonym: Fuzzy coat
Synonym: Fuzzy coat of cell
Synonym: Glycocalix
Synonym: Glycocalyx (body structure)
Synonym: Glycocalyx (cell structure)
Tree Number: T1.4.1.6.6
Tree Number: T2.8.1.6.6
database_cross_reference: CHV:0000014114
database_cross_reference: FMA:66838
database_cross_reference: GO:GO:0030112
database_cross_reference: MSH:D019276
database_cross_reference: NCI:C32689
database_cross_reference: SNMI:T-E0280
database_cross_reference: SNOMEDCT_US:19052001
database_cross_reference: UWDA:66838

Membrane Microdomains
type: Class
subclass of: Cell Membrane Structures
PMOID: PMO:00000353
Subclass_of: Cell Membrane Structures
Synonym: Lipid Rafts, Cell Membrane
Synonym: Membrane Microdomain
Synonym: Microdomain, Membrane
Synonym: Microdomain, Sphingolipid
Synonym: Microdomains, Membrane
Synonym: Microdomains, Sphingolipid
Synonym: Sphingolipid Cholesterol Rafts
Synonym: Sphingolipid Microdomain
Synonym: Sphingolipid Microdomains
Synonym: Sphingolipid-Cholesterol Raft
Tree Number: T1.4.1.6.7
Tree Number: T2.8.1.6.7
database_cross_reference: GO:GO:0098857
database_cross_reference: MSH:D021962

Cell-Matrix Junctions
type: Class
subclass of: Cell Membrane Structures
PMOID: PMO:00000354
Subclass_of: Cell Membrane Structures
Synonym: Adhesions, Cell-Matrix
Synonym: Cell Attachment
Synonym: Cell Matrix Adhesions
Synonym: Cell Matrix Junctions
Synonym: Cell-Matrix Adhesion Process
Synonym: Cell-Matrix Adhesions
Synonym: Cell-Matrix Junction
Synonym: Cell-matrix adhesions
Synonym: Junction, Cell-Matrix
Synonym: Junctions, Cell-Matrix
Tree Number: T1.4.1.6.8
Tree Number: T2.8.1.6.8
database_cross_reference: GO:GO:0007160
database_cross_reference: GO:GO:0030055
database_cross_reference: LCH_NW:sh2011005720
database_cross_reference: MSH:D021982
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C20191

Phycobilisomes
type: Class
subclass of: Cell Membrane Structures
PMOID: PMO:00000358
Subclass_of: Cell Membrane Structures
Synonym: Phycobilisome
Synonym: Phycobilisomes [Chemical/Ingredient]
Synonym: phycobilisome
Tree Number: T1.4.1.6.9
Tree Number: T2.8.1.6.9
database_cross_reference: GO:GO:0030089
database_cross_reference: LCH_NW:sh2004010855
database_cross_reference: MSH:D045524
database_cross_reference: NDFRT:N0000167473

Cell Wall
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000359
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Cell Walls
Synonym: Wall, Cell
Synonym: Walls, Cell
Synonym: cell wall
Synonym: cell walls
Tree Number: T1.4.2
Tree Number: T2.8.2
database_cross_reference: CHV:0000002601
database_cross_reference: CSP:0594-1156
database_cross_reference: GO:GO:0005618
database_cross_reference: MSH:D002473

Cell Wall Skeleton
type: Class
subclass of: Cell Wall
subclass of: PMO:00021903
PMOID: PMO:00000360
Subclass_of: Bacterial Proteins
Subclass_of: Cell Wall
Synonym: Cell Wall Skeleton [Chemical/Ingredient]
Synonym: cell wall skeleton
Tree Number: T1.4.2.1
Tree Number: T2.8.2.1
Tree Number: T6.10.3.10.15
database_cross_reference: MSH:D017358
database_cross_reference: NDDF:009111
database_cross_reference: NDFRT:N0000169173

Inclusion Bodies
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000361
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Bodies, Inclusion
Synonym: Body, Inclusion
Synonym: Cellular Inclusion
Synonym: Cellular Inclusions
Synonym: INCLUSION
Synonym: Inclusion Body
Synonym: Inclusion, Cellular
Synonym: Inclusions
Synonym: Inclusions, Cellular
Synonym: body inclusion
Tree Number: T1.4.3
Tree Number: T2.8.3
database_cross_reference: CHV:0000002605
database_cross_reference: CSP:0602-4404
database_cross_reference: GO:GO:0016234
database_cross_reference: MSH:D002479
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C120945
database_cross_reference: NCI_CDISC:C120945

Erythrocyte Inclusions
type: Class
subclass of: Inclusion Bodies
subclass of: Erythrocytes, Abnormal
PMOID: PMO:00000362
Subclass_of: Erythrocytes, Abnormal
Subclass_of: Inclusion Bodies
Synonym: Erythrocyte Inclusion
Synonym: Erythrocyte inclusion
Synonym: Erythrocyte inclusion (morphologic abnormality)
Synonym: Inclusion, Erythrocyte
Synonym: Inclusions, Erythrocyte
Tree Number: T1.4.3.1
Tree Number: T2.4.2.2.2
Tree Number: T2.8.3.1
database_cross_reference: MSH:D004908
database_cross_reference: MTH:NOCODE
database_cross_reference: SNOMEDCT_US:397060004

Heinz Bodies
type: Class
subclass of: Erythrocyte Inclusions
PMOID: PMO:00000363
Subclass_of: Erythrocyte Inclusions
Synonym: Bodies, Heinz
Synonym: HEINZ BODIES
Synonym: Heinz Body
Synonym: Heinz bodies
Synonym: Heinz body
Synonym: Heinz body (morphologic abnormality)
Synonym: Heinz-Ehrlich body
Synonym: heinz bodies
Synonym: heinz body
Tree Number: T1.4.3.1.1
Tree Number: T2.8.3.1.1
database_cross_reference: CHV:0000005918
database_cross_reference: CST:HEINZ BODIES
database_cross_reference: DXP:U001924
database_cross_reference: LCH:U002118
database_cross_reference: LCH_NW:sh85059964
database_cross_reference: LNC:LP17332-5
database_cross_reference: LNC:MTHU023292
database_cross_reference: MDR:10019372
database_cross_reference: MSH:D006366
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C34672
database_cross_reference: SNM:M-78460
database_cross_reference: SNMI:M-63420
database_cross_reference: SNOMEDCT_US:42222008

Inclusion Bodies, Viral
type: Class
subclass of: Inclusion Bodies
PMOID: PMO:00000364
Subclass_of: Inclusion Bodies
Synonym: Bodies, Viral Inclusion
Synonym: Body, Viral Inclusion
Synonym: Inclusion Body, Viral
Synonym: Viral Inclusion Bodies
Synonym: Viral Inclusion Body
Synonym: Viral inclusion bodies
Synonym: Viral inclusion body
Synonym: Viral inclusion body (morphologic abnormality)
Synonym: Viral inclusion body, NOS
Tree Number: T1.4.3.2
Tree Number: T2.8.3.2
database_cross_reference: LNC:LP15190-9
database_cross_reference: LNC:MTHU002585
database_cross_reference: MSH:D007181
database_cross_reference: SNMI:M-62800
database_cross_reference: SNOMEDCT_US:53012008

Lewy Bodies
type: Class
subclass of: Inclusion Bodies
subclass of: Neurons
PMOID: PMO:00000365
Subclass_of: Inclusion Bodies
Subclass_of: Neurons
Synonym: Bodies, Lewy
Synonym: Body, Lewy
Synonym: Lewy Body
Synonym: Lewy bodies
Synonym: Lewy bodies (morphologic abnormality)
Synonym: Lewy body
Synonym: bodies lewi
Synonym: bodies lewis
Synonym: bodies lewy
Synonym: body lewi
Tree Number: T1.4.3.3
Tree Number: T2.23.14
Tree Number: T2.8.3.3
database_cross_reference: CHV:0000015490
database_cross_reference: CSP:4006-0057
database_cross_reference: GO:GO:0097413
database_cross_reference: HPO:HP:0100315
database_cross_reference: MSH:D016631
database_cross_reference: OMIM:MTHU035458
database_cross_reference: SNM:M-66700
database_cross_reference: SNMI:M-62678
database_cross_reference: SNOMEDCT_US:43127003

Intranuclear Inclusion Bodies
type: Class
subclass of: Inclusion Bodies
PMOID: PMO:00000366
Subclass_of: Inclusion Bodies
Synonym: Inclusion Bodies, Intranuclear
Synonym: Inclusion Bodies, Nuclear
Synonym: Inclusion Body, Intranuclear
Synonym: Inclusion Body, Nuclear
Synonym: Inclusion, Intranuclear
Synonym: Inclusion, Nuclear
Synonym: Inclusions, Intranuclear
Synonym: Inclusions, Nuclear
Synonym: Intranuclear Inclusion
Synonym: Intranuclear Inclusion Body
Tree Number: T1.4.3.4
Tree Number: T2.8.3.4
database_cross_reference: FMA:67221
database_cross_reference: GO:GO:0042405
database_cross_reference: MSH:D045586
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C36017
database_cross_reference: SNM:M-65500
database_cross_reference: SNMI:T-E0180
database_cross_reference: SNOMEDCT_US:13698008
database_cross_reference: SNOMEDCT_VET:312791000009106
database_cross_reference: UWDA:67221

Mallory Bodies
type: Class
subclass of: Inclusion Bodies
PMOID: PMO:00000367
Subclass_of: Inclusion Bodies
Tree Number: T1.4.3.5
Tree Number: T2.8.3.5

Chromosomes
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000368
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: CHROMOSOME
Synonym: Chromosomal
Synonym: Chromosome
Synonym: Chromosome (body structure)
Synonym: Chromosome (cell structure)
Synonym: Chromosome, NOS
Synonym: chromosome
Synonym: chromosomes
Tree Number: T1.4.4
Tree Number: T2.8.4
database_cross_reference: AOD:0000002907
database_cross_reference: CCPSS:0059984
database_cross_reference: CHV:0000002946
database_cross_reference: CSP:1255-7932
database_cross_reference: FMA:67093
database_cross_reference: GO:GO:0005694
database_cross_reference: LCH:U001014
database_cross_reference: LCH_NW:sh85025391
database_cross_reference: LNC:LP20948-3
database_cross_reference: LNC:LP32750-9
database_cross_reference: LNC:MTHU047638
database_cross_reference: MSH:D002875
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13202
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046470
database_cross_reference: PSY:09170
database_cross_reference: RCD:Xa0dt
database_cross_reference: SNM:T-YX100
database_cross_reference: SNM:U000526
database_cross_reference: SNMI:T-E0130
database_cross_reference: SNOMEDCT_US:91272006
database_cross_reference: UWDA:67093

Chromosomes, Bacterial
type: Class
subclass of: Chromosomes
PMOID: PMO:00000369
Subclass_of: Chromosomes
Synonym: BACT CHROMOSOME
Synonym: BACT CHROMOSOMES
Synonym: Bacterial Chromosome
Synonym: Bacterial Chromosomes
Synonym: Bacterial chromosomes
Synonym: CHROMOSOME BACT
Synonym: CHROMOSOMES BACT
Synonym: Chromosome, Bacterial
Tree Number: T1.4.4.1
Tree Number: T2.8.4.1
database_cross_reference: LCH_NW:sh89006409
database_cross_reference: MSH:D002876

Chromosomes, Artificial, Bacterial
type: Class
subclass of: Chromosomes, Bacterial
subclass of: Chromosomes, Artificial
PMOID: PMO:00000370
Subclass_of: Chromosomes, Artificial
Subclass_of: Chromosomes, Bacterial
Tree Number: T1.4.4.1.1
Tree Number: T1.4.4.7.2
Tree Number: T2.8.4.1.1
Tree Number: T2.8.4.7.2

Ring Chromosomes
type: Class
subclass of: Chromosomes
PMOID: PMO:00000371
Subclass_of: Chromosomes
Synonym: Chromosome, Ring
Synonym: Chromosomes, Ring
Synonym: Ring Chromosome
Synonym: Ring Chromosomes [Disease/Finding]
Synonym: Ring chromosome
Synonym: Ring chromosome (morphologic abnormality)
Synonym: Supernumerary Circular Chromosome
Synonym: chromosome ring
Synonym: r
Synonym: ring chromosome
Tree Number: T1.4.4.2
Tree Number: T2.8.4.2
database_cross_reference: CHV:0000010907
database_cross_reference: MSH:D012303
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C3360
database_cross_reference: NDFRT:N0000002649
database_cross_reference: SNM:M-63330
database_cross_reference: SNMI:M-61280
database_cross_reference: SNOMEDCT_US:23345003

Sex Chromosomes
type: Class
subclass of: Chromosomes
PMOID: PMO:00000372
Subclass_of: Chromosomes
Synonym: Chromosome, Sex
Synonym: Chromosomes, Sex
Synonym: Gonosome
Synonym: Gonosomes
Synonym: Sex Chromosome
Synonym: Sex chromosome
Synonym: Sex chromosome (body structure)
Synonym: Sex chromosome (cell structure)
Synonym: Sex chromosome structure
Synonym: Sex chromosome structure (body structure)
Tree Number: T1.4.4.3
Tree Number: T2.8.4.3
database_cross_reference: CHV:0000011264
database_cross_reference: CSP:1256-1296
database_cross_reference: FMA:74407
database_cross_reference: GO:GO:0000803
database_cross_reference: LCH:U004282
database_cross_reference: LCH_NW:sh85120570
database_cross_reference: MSH:D012730
database_cross_reference: NCI:C33542
database_cross_reference: PSY:46840
database_cross_reference: SNM:T-YX123
database_cross_reference: SNMI:T-E0159
database_cross_reference: SNOMEDCT_US:312238009
database_cross_reference: SNOMEDCT_US:32247007
database_cross_reference: UWDA:74407

Pseudoautosomal Regions
type: Class
subclass of: Sex Chromosomes
PMOID: PMO:00000373
Subclass_of: Sex Chromosomes
Synonym: Pseudoautosomal Region
Tree Number: T1.4.4.3.1
Tree Number: T2.8.4.3.1
database_cross_reference: MSH:D000071439
database_cross_reference: NCI:C42296

Sex Chromatin
type: Class
subclass of: Sex Chromosomes
PMOID: PMO:00000374
Subclass_of: Sex Chromosomes
Synonym: Barr Bodies
Synonym: Barr Body
Synonym: Barr bodies
Synonym: Barr body
Synonym: Barr chromatin body
Synonym: Bodies, Barr
Synonym: Chromatin, Sex
Synonym: Chromatins, Sex
Synonym: Sex Chromatins
Synonym: Sex chromatin
Tree Number: T1.4.4.3.2
Tree Number: T2.8.4.3.2
database_cross_reference: CHV:0000011262
database_cross_reference: FMA:84718
database_cross_reference: GO:GO:0001739
database_cross_reference: GO:GO:0001740
database_cross_reference: LCH:U004280
database_cross_reference: LCH_NW:sh85120567
database_cross_reference: LNC:LA11179-1
database_cross_reference: LNC:LP18339-9
database_cross_reference: LNC:MTHU004078
database_cross_reference: MSH:D012728
database_cross_reference: NCI:C32182
database_cross_reference: SNM:T-YX074
database_cross_reference: SNMI:T-E0126
database_cross_reference: SNOMEDCT_US:58348001

X Chromosome
type: Class
subclass of: Sex Chromosomes
PMOID: PMO:00000375
Subclass_of: Sex Chromosomes
Synonym: Chromosome X
Synonym: Chromosome, X
Synonym: Chromosomes, X
Synonym: Female sex chromosome
Synonym: Sex chromosome X
Synonym: Sex chromosome X (body structure)
Synonym: Sex chromosome X (cell structure)
Synonym: X Chromosomes
Synonym: X chromosome
Synonym: chromosome x
Tree Number: T1.4.4.3.3
Tree Number: T2.8.4.3.3
database_cross_reference: CHV:0000013214
database_cross_reference: CSP:1256-1296
database_cross_reference: FMA:84055
database_cross_reference: GO:GO:0000805
database_cross_reference: LCH:U005052
database_cross_reference: LCH_NW:sh85148724
database_cross_reference: LNC:LA21276-3
database_cross_reference: MSH:D014960
database_cross_reference: NCI:C13285
database_cross_reference: SNM:T-YX12X
database_cross_reference: SNMI:T-E015A
database_cross_reference: SNOMEDCT_US:72837006

Y Chromosome
type: Class
subclass of: Sex Chromosomes
PMOID: PMO:00000377
Subclass_of: Sex Chromosomes
Synonym: Chromosome Y
Synonym: Chromosome, Y
Synonym: Chromosomes, Y
Synonym: Male sex chromosome
Synonym: Sex chromosome Y
Synonym: Sex chromosome Y (body structure)
Synonym: Sex chromosome Y (cell structure)
Synonym: Y Chromosomes
Synonym: Y chromosome
Synonym: chromosome male sex
Tree Number: T1.4.4.3.4
Tree Number: T2.8.4.3.4
database_cross_reference: CHV:0000013245
database_cross_reference: CSP:1256-1296
database_cross_reference: FMA:84056
database_cross_reference: GO:GO:0000806
database_cross_reference: LCH:U005067
database_cross_reference: LCH_NW:sh85148874
database_cross_reference: LNC:LA21277-1
database_cross_reference: LNC:LP33230-1
database_cross_reference: LNC:MTHU048884
database_cross_reference: MSH:D014998
database_cross_reference: NCI:C13286
database_cross_reference: SNM:T-YX12Y
database_cross_reference: SNMI:T-E015B
database_cross_reference: SNOMEDCT_US:5421003

Chromosomes, Fungal
type: Class
subclass of: Chromosomes
PMOID: PMO:00000379
Subclass_of: Chromosomes
Synonym: Chromosome, Fungal
Synonym: Fungal Chromosome
Synonym: Fungal Chromosomes
Tree Number: T1.4.4.4
Tree Number: T2.8.4.4
database_cross_reference: MSH:D015825

Chromosomes, Artificial, Yeast
type: Class
subclass of: Chromosomes, Fungal
subclass of: Chromosomes, Artificial
PMOID: PMO:00000380
Subclass_of: Chromosomes, Artificial
Subclass_of: Chromosomes, Fungal
Tree Number: T1.4.4.4.1
Tree Number: T1.4.4.7.1
Tree Number: T2.8.4.4.1
Tree Number: T2.8.4.7.1

Isochromosomes
type: Class
subclass of: Chromosomes
PMOID: PMO:00000381
Subclass_of: Chromosomes
Synonym: Isochromosome
Synonym: Isochromosomes [Disease/Finding]
Synonym: isochromosome
Tree Number: T1.4.4.5
Tree Number: T2.8.4.5
database_cross_reference: CHV:0000024890
database_cross_reference: MSH:D018404
database_cross_reference: NCI:C3897
database_cross_reference: NDFRT:N0000003810

Chromosomes, Archaeal
type: Class
subclass of: Chromosomes
PMOID: PMO:00000382
Subclass_of: Chromosomes
Synonym: Archaeal Chromosome
Synonym: Archaeal Chromosomes
Synonym: Chromosome, Archaeal
Tree Number: T1.4.4.6
Tree Number: T2.8.4.6
database_cross_reference: MSH:D019847

Chromosomes, Artificial
type: Class
subclass of: Chromosomes
PMOID: PMO:00000383
Subclass_of: Chromosomes
Tree Number: T1.4.4.7
Tree Number: T2.8.4.7

Chromosomes, Artificial, Mammalian
type: Class
subclass of: Chromosomes, Artificial
subclass of: Chromosomes, Mammalian
PMOID: PMO:00000384
Subclass_of: Chromosomes, Artificial
Subclass_of: Chromosomes, Mammalian
Tree Number: T1.4.4.7.3
Tree Number: T1.4.4.9.2
Tree Number: T2.8.4.7.3
Tree Number: T2.8.4.9.2

Chromosomes, Artificial, P1 Bacteriophage
type: Class
subclass of: Chromosomes, Artificial
PMOID: PMO:00000386
Subclass_of: Chromosomes, Artificial
Tree Number: T1.4.4.7.4
Tree Number: T2.8.4.7.4

Chromosomes, Plant
type: Class
subclass of: Chromosomes
PMOID: PMO:00000387
Subclass_of: Chromosomes
Tree Number: T1.4.4.8
Tree Number: T2.8.4.8

Chromosomes, Mammalian
type: Class
subclass of: Chromosomes
PMOID: PMO:00000388
Subclass_of: Chromosomes
Synonym: Chromosome, Mammalian
Synonym: Mammalian Chromosome
Synonym: Mammalian Chromosomes
Tree Number: T1.4.4.9
Tree Number: T2.8.4.9
database_cross_reference: MSH:D033481

Chromosomes, Human
type: Class
subclass of: Chromosomes, Mammalian
PMOID: PMO:00000389
Subclass_of: Chromosomes, Mammalian
Synonym: Chromosome, Human
Synonym: Human Chromosome
Synonym: Human Chromosomes
Synonym: Human chromosomes
Synonym: human chromosome
Synonym: human chromosomes
Tree Number: T1.4.4.9.1
Tree Number: T2.8.4.9.1
database_cross_reference: CHV:0000002947
database_cross_reference: LCH_NW:sh85062851
database_cross_reference: MSH:D002877
database_cross_reference: NCI:C13203

Chromosomes, Insect
type: Class
subclass of: Chromosomes
PMOID: PMO:00000420
Subclass_of: Chromosomes
Tree Number: T1.4.4.10
Tree Number: T2.8.4.10

Polytene Chromosomes
type: Class
subclass of: Chromosomes, Insect
PMOID: PMO:00000421
Subclass_of: Chromosomes, Insect
Synonym: Chromosome, Polytene
Synonym: Chromosomes, Polytene
Synonym: Polytene Chromosome
Synonym: polytene chromosome
Tree Number: T1.4.4.10.1
Tree Number: T2.8.4.10.1
database_cross_reference: GO:GO:0005700
database_cross_reference: MSH:D059007

Extracellular Vesicles
type: Class
subclass of: Extracellular Space
PMOID: PMO:00000422
Subclass_of: Extracellular Space
Synonym: Extracellular Vesicle
Synonym: Vesicle, Extracellular
Synonym: Vesicles, Extracellular
Synonym: extracellular vesicle
Tree Number: T1.4.5.1
Tree Number: T2.8.5.1
database_cross_reference: GO:GO:1903561
database_cross_reference: MSH:D000067128

Cell-Derived Microparticles
type: Class
subclass of: Extracellular Vesicles
PMOID: PMO:00000423
Subclass_of: Extracellular Vesicles
Synonym: Cell Derived Microparticles
Synonym: Cell Membrane Microparticle
Synonym: Cell Membrane Microparticles
Synonym: Cell-Derived Microparticle
Synonym: Circulating Microparticle
Synonym: Circulating Microvesicle
Synonym: Ectosome
Synonym: Ectosomes
Synonym: Membrane Microparticle, Cell
Synonym: Membrane Microparticles, Cell
Tree Number: T1.4.5.1.1
Tree Number: T2.8.5.1.1
database_cross_reference: GO:GO:1990742
database_cross_reference: MSH:D055252
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C120025

Exosomes
type: Class
subclass of: Extracellular Vesicles
PMOID: PMO:00000424
Subclass_of: Extracellular Vesicles
Synonym: Exosome
Synonym: exosome
Synonym: extracellular exosome
Synonym: extracellular vesicular exosome
Tree Number: T1.4.5.1.2
Tree Number: T2.8.5.1.2
database_cross_reference: GO:GO:0070062
database_cross_reference: MSH:D055354
database_cross_reference: NCI:C104457

Extracellular Matrix
type: Class
subclass of: Extracellular Space
PMOID: PMO:00000425
Subclass_of: Extracellular Space
Synonym: Cell-Extracellular Matrix
Synonym: ECM
Synonym: Extracellular Matrices
Synonym: Extracellular matrix
Synonym: ICM
Synonym: Intercellular matrix
Synonym: Matrices, Extracellular
Synonym: Matrix, Extracellular
Synonym: Portion of extracellular matrix
Synonym: ecm
Tree Number: T1.4.5.2
Tree Number: T2.8.5.2
database_cross_reference: CHV:0000004796
database_cross_reference: CSP:0595-5294
database_cross_reference: FMA:9672
database_cross_reference: GO:GO:0031012
database_cross_reference: LCH:U001709
database_cross_reference: LCH_NW:sh85057464
database_cross_reference: MSH:D005109
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13232
database_cross_reference: UWDA:9672

Microfibrils
type: Class
subclass of: Extracellular Matrix
PMOID: PMO:00000426
Subclass_of: Extracellular Matrix
Synonym: Microfibril
Synonym: extended fibrils
Synonym: microfibril
Tree Number: T1.4.5.2.2
Tree Number: T2.8.5.2.2
database_cross_reference: GO:GO:0001527
database_cross_reference: MSH:D020894

Periplasm
type: Class
subclass of: Extracellular Space
PMOID: PMO:00000427
Subclass_of: Extracellular Space
Synonym: Periplasmic Space
Synonym: Periplasmic Spaces
Synonym: Periplasms
Synonym: Space, Periplasmic
Synonym: Spaces, Periplasmic
Synonym: periplasm
Synonym: periplasmic
Synonym: periplasmic space
Tree Number: T1.4.5.3
Tree Number: T2.8.5.3
database_cross_reference: CHV:0000038387
database_cross_reference: CSP:4008-0076
database_cross_reference: GO:GO:0042597
database_cross_reference: MSH:D019897
database_cross_reference: MTH:NOCODE

Extracellular Fluid
type: Class
subclass of: Extracellular Space
PMOID: PMO:00000428
Subclass_of: Extracellular Space
Synonym: Extracellular Fluids
Synonym: Extracellular fluid
Synonym: Extracellular fluid (substance)
Synonym: Fluid, Extracellular
Synonym: Fluids, Extracellular
Synonym: extracellular fluid
Synonym: extracellular fluids
Tree Number: T1.4.5.4
Tree Number: T2.8.5.4
database_cross_reference: CHV:0000004795
database_cross_reference: LCH_NW:sh85046576
database_cross_reference: LNC:LP172617-5
database_cross_reference: LNC:MTHU046292
database_cross_reference: MSH:D045604
database_cross_reference: SNM:T-00080
database_cross_reference: SNMI:T-D0071
database_cross_reference: SNOMEDCT_US:55450009

Extracellular Traps
type: Class
subclass of: Extracellular Space
PMOID: PMO:00000429
Subclass_of: Extracellular Space
Synonym: DNA Trap, Extracellular
Synonym: DNA Traps, Extracellular
Synonym: Extracellular DNA Trap
Synonym: Extracellular DNA Traps
Synonym: Extracellular Trap
Synonym: Trap, Extracellular
Synonym: Trap, Extracellular DNA
Synonym: Traps, Extracellular
Synonym: Traps, Extracellular DNA
Tree Number: T1.4.5.5
Tree Number: T2.8.5.5
database_cross_reference: MSH:D065206

Subcellular Fractions
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000430
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Fraction, Subcellular
Synonym: Fractions, Subcellular
Synonym: Subcellular Fraction
Synonym: Subcellular structure, isolated by fractionation technique
Synonym: Subcellular structure, isolated by fractionation technique (body structure)
Synonym: Subcellular structure, isolated by fractionation technique (cell structure)
Tree Number: T1.4.6
Tree Number: T2.8.6
database_cross_reference: MSH:D013347
database_cross_reference: SNMI:T-E0002
database_cross_reference: SNOMEDCT_US:90503007

Cell-Free System
type: Class
subclass of: Subcellular Fractions
PMOID: PMO:00000431
Subclass_of: Subcellular Fractions
Synonym: Cell Free System
Synonym: Cell-Free Systems
Synonym: Cell-free System
Synonym: Cellfree System
Synonym: Cellfree Systems
Synonym: System, Cell-Free
Synonym: System, Cellfree
Synonym: Systems, Cell-Free
Synonym: Systems, Cellfree
Synonym: cell free system
Tree Number: T1.4.6.1
Tree Number: T2.8.6.1
database_cross_reference: CSP:0602-1695
database_cross_reference: MSH:D002474
database_cross_reference: NCI:C15201

Intracellular Fluid
type: Class
subclass of: Intracellular Space
subclass of: Subcellular Fractions
PMOID: PMO:00000432
Subclass_of: Intracellular Space
Subclass_of: Subcellular Fractions
Synonym: Fluid, Intracellular
Synonym: Fluids, Intracellular
Synonym: Intracellular Fluids
Synonym: Intracellular fluid
Synonym: Intracellular fluid (substance)
Synonym: intracellular fluid
Synonym: intracellular fluids
Tree Number: T1.4.6.2
Tree Number: T1.4.8.3
Tree Number: T2.8.6.2
Tree Number: T2.8.8.3
database_cross_reference: CHV:0000006869
database_cross_reference: LNC:LP172618-3
database_cross_reference: LNC:MTHU046291
database_cross_reference: MSH:D007424
database_cross_reference: SNM:T-00090
database_cross_reference: SNMI:T-D0072
database_cross_reference: SNOMEDCT_US:20125000

Cytosol
type: Class
subclass of: Intracellular Fluid
subclass of: Cytoplasm
PMOID: PMO:00000433
Subclass_of: Cytoplasm
Subclass_of: Intracellular Fluid
Synonym: Cell Matrix
Synonym: Cytomatrix
Synonym: Cytoplasmic Matrix
Synonym: Cytoplasmic matrix
Synonym: Cytoplasmic matrix (body structure)
Synonym: Cytoplasmic matrix (cell structure)
Synonym: Cytoplasmic matrix, NOS
Synonym: Cytosolic
Synonym: Cytosols
Synonym: Hyaloplasm
Tree Number: T1.4.6.2.1
Tree Number: T1.4.8.2.1
Tree Number: T1.4.8.3.1
Tree Number: T2.8.6.2.1
Tree Number: T2.8.8.2.1
Tree Number: T2.8.8.3.1
database_cross_reference: AOD:0000027598
database_cross_reference: CHV:0000003594
database_cross_reference: CSP:0595-2394
database_cross_reference: FMA:66836
database_cross_reference: GO:GO:0005829
database_cross_reference: LCH:U001264
database_cross_reference: LCH_NW:sh85035257
database_cross_reference: MSH:D003600
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32424
database_cross_reference: NCI:C61554
database_cross_reference: SNMI:T-E0300
database_cross_reference: SNOMEDCT_US:62035001
database_cross_reference: UWDA:66836

Microsomes
type: Class
subclass of: Subcellular Fractions
PMOID: PMO:00000434
Subclass_of: Subcellular Fractions
Synonym: Endoplasmic reticulum vesicle
Synonym: Microsome
Synonym: microsome
Synonym: microsomes
Synonym: obsolete microsome
Tree Number: T1.4.6.4
Tree Number: T2.8.6.4
database_cross_reference: AOD:0000016733
database_cross_reference: CHV:0000008113
database_cross_reference: CSP:0596-7378
database_cross_reference: FMA:67438
database_cross_reference: GO:GO:0005792
database_cross_reference: LCH:U002970
database_cross_reference: LCH_NW:sh85084921
database_cross_reference: MSH:D008861
database_cross_reference: UWDA:67438

Microsomes, Liver
type: Class
subclass of: Microsomes
PMOID: PMO:00000435
Subclass_of: Microsomes
Synonym: Liver Microsome
Synonym: Liver Microsomes
Synonym: Microsome, Liver
Tree Number: T1.4.6.4.1
Tree Number: T2.8.6.4.1
database_cross_reference: MSH:D008862

Mitochondria
type: Class
subclass of: Subcellular Fractions
PMOID: PMO:00000436
Subclass_of: Subcellular Fractions
Synonym: Mitochondrial
Synonym: Mitochondrial structure
Synonym: Mitochondrial structure (body structure)
Synonym: Mitochondrial structure (cell structure)
Synonym: Mitochondrion
Synonym: Mitochondrion (body structure)
Synonym: Mitochondrion (cell structure)
Synonym: Mitochondrion, NOS
Synonym: mitochondria
Synonym: mitochondrial
Tree Number: T1.4.6.5
Tree Number: T2.8.6.5
database_cross_reference: AOD:0000016737
database_cross_reference: AOD:0000027597
database_cross_reference: CHV:0000008181
database_cross_reference: CHV:0000037962
database_cross_reference: CSP:0596-9251
database_cross_reference: FMA:63835
database_cross_reference: GO:GO:0005739
database_cross_reference: LCH:U002998
database_cross_reference: LCH_NW:sh85086280
database_cross_reference: LNC:LP16724-4
database_cross_reference: MSH:D008928
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13258
database_cross_reference: NCI_NCI-GLOSS:CDR0000044060
database_cross_reference: SNMI:T-E0700
database_cross_reference: SNOMEDCT_US:312239001
database_cross_reference: SNOMEDCT_US:75056005
database_cross_reference: UWDA:63835

Mitochondria, Liver
type: Class
subclass of: Mitochondria
PMOID: PMO:00000437
Subclass_of: Mitochondria
Synonym: Liver Mitochondria
Synonym: Liver Mitochondrion
Synonym: Mitochondrion, Liver
Tree Number: T1.4.6.5.1
Tree Number: T2.8.6.5.1
database_cross_reference: MSH:D008930

Mitochondria, Muscle
type: Class
subclass of: Mitochondria
PMOID: PMO:00000438
Subclass_of: Mitochondria
Synonym: Mitochondrion, Muscle
Synonym: Muscle Mitochondria
Synonym: Muscle Mitochondrion
Synonym: Sarcosome
Synonym: Sarcosomes
Synonym: mitochondria muscles
Synonym: muscle mitochondria
Tree Number: T1.4.6.5.2
Tree Number: T2.8.6.5.2
database_cross_reference: CHV:0000008182
database_cross_reference: MSH:D008931

Submitochondrial Particles
type: Class
subclass of: Mitochondria
PMOID: PMO:00000440
Subclass_of: Mitochondria
Synonym: Particle, Submitochondrial
Synonym: Particles, Submitochondrial
Synonym: Submitochondrial Particle
Tree Number: T1.4.6.5.3
Tree Number: T2.8.6.5.3
database_cross_reference: MSH:D013367

Synaptosomes
type: Class
subclass of: Subcellular Fractions
PMOID: PMO:00000441
Subclass_of: Subcellular Fractions
Synonym: Synaptosome
Synonym: obsolete synaptosome
Synonym: synaptoneurosome
Synonym: synaptosome
Synonym: synaptosomes
Tree Number: T1.4.6.6
Tree Number: T2.8.6.6
database_cross_reference: AOD:0000017693
database_cross_reference: CHV:0000011974
database_cross_reference: CSP:2047-3223
database_cross_reference: GO:GO:0019717
database_cross_reference: LCH:U004559
database_cross_reference: LCH_NW:sh85131594
database_cross_reference: MSH:D013574

Cell Surface Extensions
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000442
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Cell Membrane Extension
Synonym: Cell Membrane Extensions
Synonym: Cell Membrane Projection
Synonym: Cell Membrane Projections
Synonym: Cell Membrane Protrusion
Synonym: Cell Membrane Protrusions
Synonym: Cell Surface Extension
Synonym: Cell Surface Projection
Synonym: Cell Surface Projections
Synonym: Cell Surface Protrusion
Tree Number: T1.4.7
Tree Number: T2.8.7
database_cross_reference: GO:GO:0031253
database_cross_reference: MSH:D022081
database_cross_reference: NCI:C26114

Telopodes
type: Class
subclass of: Cell Surface Extensions
subclass of: Telocytes
PMOID: PMO:00000443
Subclass_of: Cell Surface Extensions
Subclass_of: Telocytes
Synonym: Telopode
Tree Number: T1.4.7.1
Tree Number: T2.10.9.1.1
Tree Number: T2.8.7.1
database_cross_reference: MSH:D000067617

Podosomes
type: Class
subclass of: Cell Surface Extensions
subclass of: Endothelial Cells
PMOID: PMO:00000444
Subclass_of: Cell Surface Extensions
Subclass_of: Endothelial Cells
Synonym: Invadopodia
Synonym: Invadopodium
Synonym: Invadopodiums
Synonym: Invadosome
Synonym: Invadosomes
Synonym: Podosome
Synonym: invadopodium
Synonym: podosome
Tree Number: T1.4.7.2
Tree Number: T2.12.27.1
Tree Number: T2.8.7.2
database_cross_reference: GO:GO:0002102
database_cross_reference: GO:GO:0071437
database_cross_reference: MSH:D000069261

Axons
type: Class
subclass of: Cell Surface Extensions
subclass of: Neurons
subclass of: Nerve Fibers
PMOID: PMO:00000445
Subclass_of: Cell Surface Extensions
Subclass_of: Nerve Fibers
Subclass_of: Neurons
Synonym: Axon
Synonym: Axon structure
Synonym: Axon structure (body structure)
Synonym: Axon structure (cell structure)
Synonym: axon
Synonym: axone
Synonym: axons
Synonym: neuraxon
Synonym: neuraxons
Tree Number: T1.4.7.3
Tree Number: T2.23.3
Tree Number: T2.23.6.3
Tree Number: T2.8.7.3
database_cross_reference: AOD:0000017681
database_cross_reference: AOD:0000027991
database_cross_reference: AOD:0000027993
database_cross_reference: CHV:0000001632
database_cross_reference: CSP:2047-3613
database_cross_reference: FMA:67308
database_cross_reference: GO:GO:0030424
database_cross_reference: LCH:U000457
database_cross_reference: LCH_NW:sh85010598
database_cross_reference: MSH:D001369
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32177
database_cross_reference: PSY:05220
database_cross_reference: SNM:T-X0280
database_cross_reference: SNMI:T-A0280
database_cross_reference: SNOMEDCT_US:60436000
database_cross_reference: UWDA:67308

Axon Initial Segment
type: Class
subclass of: Axons
PMOID: PMO:00000446
Subclass_of: Axons
Synonym: Axon Initial Segments
Synonym: Initial segment of axon
Synonym: axon initial segment
Synonym: initial segment
Tree Number: T1.4.7.3.1
Tree Number: T2.23.3.1
Tree Number: T2.23.6.3.1
Tree Number: T2.8.7.3.1
database_cross_reference: FMA:67382
database_cross_reference: GO:GO:0043194
database_cross_reference: MSH:D000071040
database_cross_reference: UWDA:67382

Growth Cones
type: Class
subclass of: Axons
subclass of: Dendrites
subclass of: Neurites
PMOID: PMO:00000447
Subclass_of: Axons
Subclass_of: Dendrites
Subclass_of: Neurites
Synonym: Growth Cone
Synonym: growth cone
Tree Number: T1.4.7.10.1
Tree Number: T1.4.7.3.2
Tree Number: T1.4.7.5.1
Tree Number: T2.23.3.4
Tree Number: T2.23.4.1
Tree Number: T2.8.7.10.1
Tree Number: T2.8.7.3.2
Tree Number: T2.8.7.5.1
database_cross_reference: CSP:2047-3450
database_cross_reference: GO:GO:0030426
database_cross_reference: MSH:D020439

Cilia
type: Class
subclass of: Cell Surface Extensions
PMOID: PMO:00000448
Subclass_of: Cell Surface Extensions
Synonym: Cilium
Synonym: Cilium (body structure)
Synonym: Cilium (cell structure)
Synonym: Cilium, NOS
Synonym: cilia
Synonym: cilium
Synonym: eukaryotic flagellum
Synonym: microtubule-based flagellum
Tree Number: T1.4.7.4
Tree Number: T2.8.7.4
database_cross_reference: AOD:0000016766
database_cross_reference: CHV:0000002990
database_cross_reference: CSP:0594-8648
database_cross_reference: FMA:67181
database_cross_reference: GO:GO:0005929
database_cross_reference: GO:GO:0031514
database_cross_reference: MSH:D002923
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32318
database_cross_reference: SNMI:T-E0460
database_cross_reference: SNOMEDCT_US:69315009
database_cross_reference: UWDA:67181

Dendrites
type: Class
subclass of: Cell Surface Extensions
subclass of: Neurons
PMOID: PMO:00000449
Subclass_of: Cell Surface Extensions
Subclass_of: Neurons
Synonym: Dendrite
Synonym: Dendrite (body structure)
Synonym: Dendrite (cell structure)
Synonym: Dendritic
Synonym: dendrite
Synonym: dendrites
Tree Number: T1.4.7.5
Tree Number: T2.23.4
Tree Number: T2.8.7.5
database_cross_reference: AOD:0000017680
database_cross_reference: CHV:0000003694
database_cross_reference: CSP:2047-3635
database_cross_reference: FMA:67314
database_cross_reference: GO:GO:0030425
database_cross_reference: LCH:U001294
database_cross_reference: LCH_NW:sh85036698
database_cross_reference: MSH:D003712
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32447
database_cross_reference: PSY:13490
database_cross_reference: SNM:T-X0270
database_cross_reference: SNMI:T-A0270
database_cross_reference: SNOMEDCT_US:90604005
database_cross_reference: UWDA:67314

Dendritic Spines
type: Class
subclass of: Dendrites
PMOID: PMO:00000450
Subclass_of: Dendrites
Synonym: Dendritic Spine
Synonym: Dendritic spine
Synonym: Dendritic spine apparatus
Synonym: Dendritic spine apparatus (body structure)
Synonym: Dendritic spine apparatus (cell structure)
Synonym: Spine, Dendritic
Synonym: Spines, Dendritic
Synonym: dendrite spine
Synonym: dendrites spines
Synonym: dendritic spine
Tree Number: T1.4.7.5.2
Tree Number: T2.23.4.2
Tree Number: T2.8.7.5.2
database_cross_reference: CHV:0000051585
database_cross_reference: CSP:2047-3635
database_cross_reference: FMA:67488
database_cross_reference: GO:GO:0043197
database_cross_reference: MSH:D049229
database_cross_reference: SNMI:T-E0591
database_cross_reference: SNOMEDCT_US:62670003
database_cross_reference: UWDA:67488

Flagella
type: Class
subclass of: Cell Surface Extensions
PMOID: PMO:00000451
Subclass_of: Cell Surface Extensions
Synonym: Flagellum
Synonym: flagella
Synonym: flagellum
Synonym: obsolete flagellum
Tree Number: T1.4.7.6
Tree Number: T2.8.7.6
database_cross_reference: AOD:0000016767
database_cross_reference: CHV:0000005075
database_cross_reference: CSP:0595-6140
database_cross_reference: FMA:67472
database_cross_reference: GO:GO:0005929
database_cross_reference: GO:GO:0019861
database_cross_reference: MSH:D005407
database_cross_reference: UWDA:67472

Sperm Tail
type: Class
subclass of: Flagella
subclass of: Spermatozoa
PMOID: PMO:00000452
Subclass_of: Flagella
Subclass_of: Spermatozoa
Synonym: Cauda (Spermatozoon)
Synonym: Cauda of sperm
Synonym: Cauda of spermatozoon
Synonym: Flagellum of spermatozoon
Synonym: Flagellum, Sperm
Synonym: Flagellums, Sperm
Synonym: Sperm Flagellum
Synonym: Sperm Flagellums
Synonym: Sperm Tails
Synonym: Spermatozoa.tail
Tree Number: T1.4.7.6.1
Tree Number: T2.15.3.2
Tree Number: T2.8.7.6.1
database_cross_reference: FMA:61843
database_cross_reference: GO:GO:0036126
database_cross_reference: LNC:LP34801-8
database_cross_reference: MSH:D013082
database_cross_reference: NCI:C33733
database_cross_reference: UWDA:61843

Microvilli
type: Class
subclass of: Cell Surface Extensions
PMOID: PMO:00000453
Subclass_of: Cell Surface Extensions
Synonym: Microvillus
Synonym: Microvillus (body structure)
Synonym: Microvillus (cell structure)
Synonym: microvilli
Synonym: microvillus
Tree Number: T1.4.7.7
Tree Number: T2.8.7.7
database_cross_reference: AOD:0000016768
database_cross_reference: CHV:0000008121
database_cross_reference: CSP:1831-7003
database_cross_reference: FMA:67296
database_cross_reference: GO:GO:0005902
database_cross_reference: MSH:D008871
database_cross_reference: NCI:C33112
database_cross_reference: SNMI:T-E0231
database_cross_reference: SNOMEDCT_US:49690003
database_cross_reference: UWDA:67296

Fimbriae, Bacterial
type: Class
subclass of: Cell Surface Extensions
PMOID: PMO:00000454
Subclass_of: Cell Surface Extensions
Synonym: BACT FIMBRIA
Synonym: BACT FIMBRIAE
Synonym: Bacterial Fimbria
Synonym: Bacterial Fimbriae
Synonym: Common Fimbria
Synonym: Common Fimbriae
Synonym: Common Pili
Synonym: Common Pilus
Synonym: Common pilum
Synonym: Common pilum (body structure)
Tree Number: T1.4.7.8
Tree Number: T2.8.7.8
database_cross_reference: CHV:0000022578
database_cross_reference: CSP:0597-6743
database_cross_reference: GO:GO:0009289
database_cross_reference: MSH:D010861
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:T-E0930
database_cross_reference: SNMI:T-E0931
database_cross_reference: SNOMEDCT_US:42529003
database_cross_reference: SNOMEDCT_US:54566003

Pseudopodia
type: Class
subclass of: Cell Surface Extensions
PMOID: PMO:00000455
Subclass_of: Cell Surface Extensions
Synonym: Pseudopodium
Synonym: pseudopod
Synonym: pseudopodium
Synonym: pseudopods
Tree Number: T1.4.7.9
Tree Number: T2.8.7.9
database_cross_reference: AOD:0000016769
database_cross_reference: CHV:0000010299
database_cross_reference: GO:GO:0031143
database_cross_reference: MSH:D011554

Neurites
type: Class
subclass of: Cell Surface Extensions
subclass of: Axons
subclass of: Neurons
PMOID: PMO:00000456
Subclass_of: Axons
Subclass_of: Cell Surface Extensions
Subclass_of: Neurons
Synonym: Appendage of neuron
Synonym: Extrasomatic region of neuron
Synonym: Neurite
Synonym: neurite
Synonym: neurites
Synonym: neuron process
Synonym: neuron projection
Synonym: neuron protrusion
Synonym: neuronal cell projection
Tree Number: T1.4.7.10
Tree Number: T2.23.13
Tree Number: T2.23.6.3.2
Tree Number: T2.8.7.10
database_cross_reference: AOD:0000027992
database_cross_reference: CHV:0000015429
database_cross_reference: CSP:2047-3613
database_cross_reference: CSP:2047-3635
database_cross_reference: FMA:61814
database_cross_reference: GO:GO:0043005
database_cross_reference: MSH:D016501
database_cross_reference: MTH:NOCODE
database_cross_reference: UWDA:61814

Pili, Sex
type: Class
subclass of: Cell Surface Extensions
PMOID: PMO:00000457
Subclass_of: Cell Surface Extensions
Synonym: Conjugative Pili
Synonym: Conjugative Pilus
Synonym: Pili, Conjugative
Synonym: Pilus, Conjugative
Synonym: Pilus, Sex
Synonym: Sex Pili
Synonym: Sex Pilus
Synonym: Sex pilum
Synonym: Sex pilum (body structure)
Synonym: Sex pilum (cell structure)
Tree Number: T1.4.7.11
Tree Number: T2.8.7.11
database_cross_reference: MSH:D018933
database_cross_reference: MTH:NOCODE
database_cross_reference: SNMI:T-E0932
database_cross_reference: SNOMEDCT_US:69540001

Cellulosomes
type: Class
subclass of: Cell Surface Extensions
PMOID: PMO:00000458
Subclass_of: Cell Surface Extensions
Synonym: Cellulosome
Synonym: cellulosome
Tree Number: T1.4.7.12
Tree Number: T2.8.7.12
database_cross_reference: GO:GO:0043263
database_cross_reference: MSH:D044603

Stereocilia
type: Class
subclass of: Cell Surface Extensions
PMOID: PMO:00000459
Subclass_of: Cell Surface Extensions
Synonym: Stereocilium
Synonym: Stereocilium (body structure)
Synonym: Stereocilium (cell structure)
Synonym: Stereovilli
Synonym: Stereovillus
Synonym: stereocilium
Tree Number: T1.4.7.13
Tree Number: T2.8.7.13
database_cross_reference: FMA:67317
database_cross_reference: GO:GO:0032420
database_cross_reference: MSH:D059547
database_cross_reference: NCI:C33614
database_cross_reference: SNMI:T-E0233
database_cross_reference: SNOMEDCT_US:36828001
database_cross_reference: UWDA:67317

Cell Nucleus
type: Class
subclass of: Intracellular Space
PMOID: PMO:00000460
Subclass_of: Intracellular Space
Synonym: Cell Nuclei
Synonym: Cell nuclei
Synonym: Cell nucleus
Synonym: NUCLEUS
Synonym: Nuclei, Cell
Synonym: Nucleic
Synonym: Nucleus
Synonym: Nucleus (body structure)
Synonym: Nucleus (cell structure)
Synonym: Nucleus of cell
Tree Number: T1.4.8.1
Tree Number: T2.8.8.1
database_cross_reference: AOD:0000016722
database_cross_reference: CHV:0000002596
database_cross_reference: CSP:0593-3664
database_cross_reference: FMA:63840
database_cross_reference: GO:GO:0005634
database_cross_reference: LCH_NW:sh85021658
database_cross_reference: LNC:LP182349-3
database_cross_reference: MSH:D002467
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13197
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C13197
database_cross_reference: NCI_NCI-GLOSS:CDR0000597161
database_cross_reference: PSY:08070
database_cross_reference: SNM:T-YX030
database_cross_reference: SNMI:T-E0100
database_cross_reference: SNOMEDCT_US:84640000
database_cross_reference: UWDA:63840

Cell Nucleus Structures
type: Class
subclass of: Cell Nucleus
PMOID: PMO:00000461
Subclass_of: Cell Nucleus
Synonym: Cell Nucleus Structure
Synonym: Cell nuclear region
Synonym: Part of cell nucleus
Synonym: Region of cell nucleus
Synonym: Structure, Cell Nucleus
Synonym: Structures, Cell Nucleus
Tree Number: T1.4.8.1.1
Tree Number: T2.8.8.1.1
database_cross_reference: FMA:66846
database_cross_reference: MSH:D022003
database_cross_reference: UWDA:66846

Chromatin
type: Class
subclass of: PMO:00023650
PMOID: PMO:00000469
Subclass_of: Nucleoproteins
Synonym: Chromatin (substance)
Synonym: Chromatin [Chemical/Ingredient]
Synonym: Chromatin, NOS
Synonym: Chromatins
Synonym: Karyoplasm
Synonym: Nuclear sap
Synonym: chromatin
Synonym: chromoplasm
Tree Number: T6.10.3.37.1
database_cross_reference: AOD:0000002903
database_cross_reference: AOD:0000022111
database_cross_reference: CHV:0000002926
database_cross_reference: CSP:1255-9141
database_cross_reference: FMA:67526
database_cross_reference: LCH:U001007
database_cross_reference: LCH_NW:sh85025333
database_cross_reference: LNC:LP30645-3
database_cross_reference: MSH:D002843
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13201
database_cross_reference: NDFRT:N0000169072
database_cross_reference: SNM:T-YX060
database_cross_reference: SNM:T-YX070
database_cross_reference: SNMI:T-E0120
database_cross_reference: SNOMEDCT_US:60085001
database_cross_reference: UWDA:67526

Micronuclei, Chromosome-Defective
type: Class
subclass of: Cell Nucleus
PMOID: PMO:00000481
Subclass_of: Cell Nucleus
Synonym: Chromosome Defective Micronuclei
Synonym: Chromosome-Defective Micronuclei
Synonym: Chromosome-Defective Micronucleus
Synonym: Micronuclei, Chromosome Defective
Synonym: Micronuclei, Chromosome-Defective [Disease/Finding]
Synonym: Micronucleus, Chromosome Defective
Synonym: Micronucleus, Chromosome-Defective
Tree Number: T1.4.8.1.2
Tree Number: T2.8.8.1.2
database_cross_reference: MSH:D048629
database_cross_reference: NDFRT:N0000011014

Micronucleus, Germline
type: Class
subclass of: Cell Nucleus
PMOID: PMO:00000482
Subclass_of: Cell Nucleus
Synonym: Germinal Micronucleus
Synonym: Germline Micronuclei
Synonym: Germline Micronucleus
Synonym: Micronuclei, Germline
Synonym: Micronucleus, Germinal
Tree Number: T1.4.8.1.3
Tree Number: T2.8.8.1.3
database_cross_reference: MSH:D048631

Macronucleus
type: Class
subclass of: Cell Nucleus
PMOID: PMO:00000483
Subclass_of: Cell Nucleus
Synonym: Macronuclei
Synonym: macronucleus
Tree Number: T1.4.8.1.4
Tree Number: T2.8.8.1.4
database_cross_reference: GO:GO:0031039
database_cross_reference: MSH:D048648
database_cross_reference: MTH:NOCODE

Cytoplasm
type: Class
subclass of: Intracellular Space
PMOID: PMO:00000484
Subclass_of: Intracellular Space
Synonym: Cytoplasma
Synonym: Cytoplasmic
Synonym: Cytoplasms
Synonym: cytoplasm
Synonym: cytoplasma
Tree Number: T1.4.8.2
Tree Number: T2.8.8.2
database_cross_reference: AOD:0000016753
database_cross_reference: CHV:0000003589
database_cross_reference: CSP:0595-2394
database_cross_reference: FMA:66835
database_cross_reference: GO:GO:0005737
database_cross_reference: LCH:U001262
database_cross_reference: LCH_NW:sh85035251
database_cross_reference: MSH:D003593
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13226
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044586
database_cross_reference: PSY:12940
database_cross_reference: SNM:T-YX020
database_cross_reference: SNMI:T-E0300
database_cross_reference: SNOMEDCT_US:62035001
database_cross_reference: UWDA:66835

Cytoplasmic Structures
type: Class
subclass of: Cytoplasm
PMOID: PMO:00000485
Subclass_of: Cytoplasm
Synonym: Cytoplasmic Structure
Synonym: Structure, Cytoplasmic
Synonym: Structures, Cytoplasmic
Tree Number: T1.4.8.2.2
Tree Number: T2.8.8.2.2
database_cross_reference: MSH:D022083

Nissl Bodies
type: Class
subclass of: Neurons
PMOID: PMO:00000491
Subclass_of: Neurons
Synonym: Bodies, Nissl
Synonym: GER aggregate
Synonym: GER aggregate (body structure)
Synonym: GER aggregate (body structure) [Ambiguous]
Synonym: GER aggregate, NOS
Synonym: Granule, Nissl
Synonym: Granules, Nissl
Synonym: Nissl Body
Synonym: Nissl Granule
Synonym: Nissl Granules
Tree Number: T2.23.11
database_cross_reference: CHV:0000008728
database_cross_reference: CSP:4000-0266
database_cross_reference: FMA:67367
database_cross_reference: LCH:U003238
database_cross_reference: LCH_NW:sh85092038
database_cross_reference: MSH:D009562
database_cross_reference: NCI:C33170
database_cross_reference: SNMI:T-E0564
database_cross_reference: SNOMEDCT_US:209599006
database_cross_reference: SNOMEDCT_US:54088008
database_cross_reference: UWDA:67367

Melanosomes
type: Class
subclass of: Melanophores
subclass of: Melanocytes
PMOID: PMO:00000493
Subclass_of: Melanocytes
Subclass_of: Melanophores
Synonym: Melanosome
Synonym: melanosome
Synonym: melanosomes
Tree Number: T2.12.11.1
Tree Number: T2.12.4.1.1
database_cross_reference: CHV:0000007897
database_cross_reference: CSP:2328-1321
database_cross_reference: FMA:70957
database_cross_reference: GO:GO:0042470
database_cross_reference: MSH:D020460
database_cross_reference: UWDA:70957

Filamins
type: Class
subclass of: PMO:00022553
PMOID: PMO:00000498
Subclass_of: Contractile Proteins
Synonym: Filamin
Synonym: Filamins [Chemical/Ingredient]
Synonym: filamin
Tree Number: T6.10.3.15.2
database_cross_reference: CSP:4000-0105
database_cross_reference: FMA:61779
database_cross_reference: MSH:D064448
database_cross_reference: NDFRT:N0000189401
database_cross_reference: UWDA:61779

Neuropil Threads
type: Class
subclass of: Neuropil
PMOID: PMO:00000500
Subclass_of: Neuropil
Synonym: Neuropil Thread
Synonym: Neuropil thread
Synonym: Neuropil thread (morphologic abnormality)
Tree Number: T2.22.6.1
Tree Number: T2.23.16.1
database_cross_reference: MSH:D019600
database_cross_reference: SNMI:M-62332
database_cross_reference: SNOMEDCT_US:33475000

Neurofibrils
type: Class
subclass of: Neurons
PMOID: PMO:00000507
Subclass_of: Neurons
Synonym: Neurofibril
Synonym: neurofibril
Tree Number: T2.23.8
database_cross_reference: CSP:2047-3691
database_cross_reference: LCH:U003186
database_cross_reference: LCH_NW:sh85091119
database_cross_reference: MSH:D009454

Neurofibrillary Tangles
type: Class
subclass of: Neurofibrils
PMOID: PMO:00000508
Subclass_of: Neurofibrils
Synonym: Alzheimer's neurofibrillary change
Synonym: Alzheimer's neurofibrillary degeneration
Synonym: Argentophilic neuronal inclusion
Synonym: NFT
Synonym: Neurofibrillary Tangle
Synonym: Neurofibrillary degeneration
Synonym: Neurofibrillary degeneration (morphologic abnormality)
Synonym: Neurofibrillary tangle
Synonym: Neurofibrillary tangles
Synonym: Neurofibrillary tangles composed of disordered microtubules in neurons
Tree Number: T2.23.8.1
database_cross_reference: CHV:0000015583
database_cross_reference: CSP:2042-3269
database_cross_reference: HPO:HP:0002185
database_cross_reference: MDR:10077196
database_cross_reference: MSH:D016874
database_cross_reference: MTH:NOCODE
database_cross_reference: OMIM:MTHU000778
database_cross_reference: SNM:M-50630
database_cross_reference: SNMI:M-50630
database_cross_reference: SNOMEDCT_US:85775002

Acrosome
type: Class
subclass of: Sperm Head
PMOID: PMO:00000537
Subclass_of: Sperm Head
Synonym: Acrosomal cap
Synonym: Acrosomal granule
Synonym: Acrosomal granule (body structure)
Synonym: Acrosomal granule (cell structure)
Synonym: Acrosomal vesicle
Synonym: Acrosomal vesicle (body structure)
Synonym: Acrosomal vesicle (cell structure)
Synonym: Acrosomes
Synonym: Lysosome of male germ cell
Synonym: Lysosome of male germ cell (body structure)
Tree Number: T2.15.3.1.1
database_cross_reference: CHV:0000000660
database_cross_reference: CSP:1138-6471
database_cross_reference: FMA:84869
database_cross_reference: GO:GO:0001669
database_cross_reference: MSH:D000177
database_cross_reference: SNMI:T-E0650
database_cross_reference: SNMI:T-E0651
database_cross_reference: SNMI:T-E0653
database_cross_reference: SNOMEDCT_US:30516005
database_cross_reference: SNOMEDCT_US:52568003
database_cross_reference: SNOMEDCT_US:75801009

Trichomes
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000551
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Indumentum
Synonym: Indumentums
Synonym: Trichome
Tree Number: T1.4.9
Tree Number: T2.8.9
database_cross_reference: MSH:D064201

Cell Body
type: Class
subclass of: Cell Component
subclass of: Cellular Structures
PMOID: PMO:00000552
Subclass_of: Cell Component
Subclass_of: Cellular Structures
Synonym: Bodies, Cell
Synonym: Body, Cell
Synonym: Cell Bodies
Synonym: Cell body
Synonym: Cell soma
Synonym: cell body
Synonym: cell soma
Tree Number: T1.4.10
Tree Number: T2.8.10
database_cross_reference: FMA:67301
database_cross_reference: GO:GO:0044297
database_cross_reference: MSH:D066146
database_cross_reference: MTH:NOCODE
database_cross_reference: UWDA:67301

Molecular Sequence
type: Class
subclass of: Anatomical Structure
PMOID: PMO:00000553
Subclass_of: Anatomical Structure
Tree Number: T1.5

Nucleotide Sequence
type: Class
subclass of: Molecular Sequence
PMOID: PMO:00000554
Subclass_of: Molecular Sequence
Synonym: BASE SEQ
Synonym: Base Sequence
Synonym: Base Sequences
Synonym: Base sequence
Synonym: Base sequence (finding)
Synonym: NUCLEOTIDE SEQ
Synonym: Nucleotide Sequences
Synonym: Nucleotide sequence
Synonym: Seq
Synonym: Sequence
Tree Number: T1.5.1
database_cross_reference: AOD:0000022133
database_cross_reference: CHV:0000001719
database_cross_reference: CSP:2102-8337
database_cross_reference: LCH_NW:sh85093159
database_cross_reference: LNC:LP62164-6
database_cross_reference: MSH:D001483
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45374
database_cross_reference: NCI:TCGA
database_cross_reference: SNMI:F-E2100
database_cross_reference: SNOMEDCT_US:72633008

Amino Acid Sequence
type: Class
subclass of: Molecular Sequence
PMOID: PMO:00000555
Subclass_of: Molecular Sequence
Synonym: AA SEQ
Synonym: AMINO ACID SEQ
Synonym: AMINO ACID SEQUENCE
Synonym: Amino Acid Sequences
Synonym: Amino acid sequence
Synonym: Amino acid sequence (finding)
Synonym: Primary Protein Structure
Synonym: Primary Protein Structures
Synonym: Protein Sequence
Synonym: Protein Structure, Primary
Tree Number: T1.5.2
database_cross_reference: CHV:0000001007
database_cross_reference: CSP:2446-2100
database_cross_reference: LCH:U000193
database_cross_reference: LCH_NW:sh85004484
database_cross_reference: MSH:D000595
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13187
database_cross_reference: NCI_FDA:C13187
database_cross_reference: NCI_NCI-GLOSS:CDR0000044184
database_cross_reference: SNMI:F-E2010
database_cross_reference: SNOMEDCT_US:28820008

Carbohydrate Sequence
type: Class
subclass of: Molecular Sequence
PMOID: PMO:00000556
Subclass_of: Molecular Sequence
Synonym: CARB SEQ
Synonym: Carbohydrate Sequences
Synonym: Carbohydrate sequence
Synonym: Carbohydrate sequence (finding)
Synonym: Sequence, Carbohydrate
Synonym: Sequences, Carbohydrate
Synonym: carbohydrate sequence
Tree Number: T1.5.3
database_cross_reference: CSP:0551-8882
database_cross_reference: MSH:D002240
database_cross_reference: SNMI:F-E2060
database_cross_reference: SNOMEDCT_US:26608005

Cell
type: Class
subclass of: Thing
PMOID: PMO:00000557
Subclass_of: owl:Thing
Synonym: Cell Type
Synonym: Cell Types
Synonym: Cell structure
Synonym: Cell structure (body structure)
Synonym: Cell structure (cell structure)
Synonym: Cell, NOS
Synonym: Cells
Synonym: Cells (Biology)
Synonym: Cells set
Synonym: Cellula
Tree Number: T2
database_cross_reference: CHV:0000002603
database_cross_reference: CSP:0605-5409
database_cross_reference: FMA:68646
database_cross_reference: FMA:71954
database_cross_reference: GO:GO:0005623
database_cross_reference: LCH:U000874
database_cross_reference: LCH_NW:sh85021678
database_cross_reference: LNC:LP14738-6
database_cross_reference: LNC:LP174115-8
database_cross_reference: LNC:MTHU001933
database_cross_reference: MSH:D002477
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12508
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046476
database_cross_reference: NCI_UCUM:C12508
database_cross_reference: PSY:08080
database_cross_reference: SNM:T-YX000
database_cross_reference: SNM:U000525
database_cross_reference: SNMI:T-E0000
database_cross_reference: SNOMEDCT_US:4421005
database_cross_reference: UWDA:68646
database_cross_reference: UWDA:71954

Acinar Cells
type: Class
subclass of: Cell
PMOID: PMO:00000558
Subclass_of: Cell
Synonym: Acinar Cell
Synonym: Acinar cell
Synonym: Acini Cell
Synonym: Acini Cells
Synonym: Acinic Cell
Synonym: Acinic Cells
Synonym: Acinous Cell
Synonym: Acinous Cells
Synonym: Acinus Cell
Synonym: Acinus Cells
Tree Number: T2.1
database_cross_reference: AOD:0000016825
database_cross_reference: CHV:0000041472
database_cross_reference: CSP:4000-0104
database_cross_reference: FMA:83625
database_cross_reference: MSH:D061354
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13077
database_cross_reference: NCI:TCGA

Antibody-Producing Cells
type: Class
subclass of: Cell
PMOID: PMO:00000559
Subclass_of: Cell
Synonym: Antibody Producing Cell
Synonym: Antibody Producing Cells
Synonym: Antibody-Producing Cell
Synonym: Cell, Antibody-Producing
Synonym: Cell, Immunoglobulin-Producing
Synonym: Cells, Antibody-Producing
Synonym: Cells, Immunoglobulin-Producing
Synonym: IG PRODUCING CELLS
Synonym: Immunoglobulin Producing Cells
Synonym: Immunoglobulin-Producing Cell
Tree Number: T2.2
database_cross_reference: MSH:D000921
database_cross_reference: NCI:C12611

B-Lymphocytes
type: Class
subclass of: Antibody-Producing Cells
PMOID: PMO:00000560
Subclass_of: Antibody-Producing Cells
Synonym: B Cell
Synonym: B Cells
Synonym: B Lymphocytes
Synonym: B cell
Synonym: B cells
Synonym: B lymphocyte
Synonym: B lymphocyte (cell)
Synonym: B-Cell
Synonym: B-Cells
Synonym: B-Lymphocyte
Tree Number: T2.2.1
database_cross_reference: AOD:0000017487
database_cross_reference: AOD:0000027929
database_cross_reference: AOD:0000027931
database_cross_reference: CHV:0000001646
database_cross_reference: CSP:0435-7975
database_cross_reference: FMA:62869
database_cross_reference: LCH_NW:sh85010707
database_cross_reference: LNC:LA4275-9
database_cross_reference: LNC:LP15088-5
database_cross_reference: LNC:LP36861-0
database_cross_reference: LNC:MTHU002435
database_cross_reference: MEDCIN:12035
database_cross_reference: MSH:D001402
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12474
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044953
database_cross_reference: NCI_NCI-GLOSS:CDR0000045611
database_cross_reference: RCD:X80V8
database_cross_reference: SNM:F-40640
database_cross_reference: SNMI:F-C6040
database_cross_reference: SNOMEDCT_US:112130006

Plasma Cells
type: Class
subclass of: B-Lymphocytes
PMOID: PMO:00000561
Subclass_of: B-Lymphocytes
Synonym: Blood plasma cell
Synonym: Cell, Plasma
Synonym: Cells, Plasma
Synonym: Plasma Cell
Synonym: Plasma cell
Synonym: Plasma cell (body structure)
Synonym: Plasma cell (cell)
Synonym: Plasma cell, NOS
Synonym: Plasma cells
Synonym: Plasma cells.centroblasts
Tree Number: T2.2.1.1
database_cross_reference: AOD:0000017489
database_cross_reference: AOD:0000027935
database_cross_reference: CHV:0000009807
database_cross_reference: CSP:0432-7249
database_cross_reference: FMA:70574
database_cross_reference: FMA:84370
database_cross_reference: LCH:U003706
database_cross_reference: LCH_NW:sh85103058
database_cross_reference: LNC:LP14037-3
database_cross_reference: LNC:LP183494-6
database_cross_reference: LNC:LP183495-3
database_cross_reference: LNC:LP68360-4
database_cross_reference: LNC:MTHU011655
database_cross_reference: MSH:D010950
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12486
database_cross_reference: NCI_NCI-GLOSS:CDR0000044795
database_cross_reference: NCI_NCI-GLOSS:CDR0000046230
database_cross_reference: NCI_NCI-GLOSS:CDR0000633941
database_cross_reference: RCD:X80V9
database_cross_reference: SNM:T-05320
database_cross_reference: SNM:T-0X270
database_cross_reference: SNMI:T-C1750
database_cross_reference: SNOMEDCT_US:113335003

B-Lymphocyte Subsets
type: Class
subclass of: B-Lymphocytes
PMOID: PMO:00000562
Subclass_of: B-Lymphocytes
Tree Number: T2.2.1.2

B-Lymphocytes, Regulatory
type: Class
subclass of: B-Lymphocyte Subsets
PMOID: PMO:00000563
Subclass_of: B-Lymphocyte Subsets
Synonym: B Cells, Regulatory
Synonym: B Lymphocytes, Regulatory
Synonym: B-Cell, Regulatory
Synonym: B-Cells, Regulatory
Synonym: B-Lymphocyte, Regulatory
Synonym: Breg
Synonym: Breg Cell
Synonym: Breg Cells
Synonym: Bregs
Synonym: Cell, Breg
Tree Number: T2.2.1.2.1
database_cross_reference: MSH:D060151
database_cross_reference: NCI:C113502

Antigen-Presenting Cells
type: Class
subclass of: Cell
PMOID: PMO:00000564
Subclass_of: Cell
Synonym: ACCESSORY CELL IMMUNOL
Synonym: ACCESSORY CELLS IMMUNOL
Synonym: APC
Synonym: Accessory Cell
Synonym: Accessory Cell, Immunologic
Synonym: Accessory Cells, Immunologic
Synonym: Antigen Presenting Cell
Synonym: Antigen Presenting Cells
Synonym: Antigen Processing Cell
Synonym: Antigen presenting cell
Tree Number: T2.3
database_cross_reference: CHV:0000001291
database_cross_reference: CSP:0605-5488
database_cross_reference: FMA:273565
database_cross_reference: LCH_NW:sh87006338
database_cross_reference: MSH:D000938
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12621
database_cross_reference: NCI_NCI-GLOSS:CDR0000043977
database_cross_reference: NCI_NCI-GLOSS:CDR0000044914

Dendritic Cells
type: Class
subclass of: Antigen-Presenting Cells
subclass of: Epithelial Cells
PMOID: PMO:00000565
Subclass_of: Antigen-Presenting Cells
Subclass_of: Epithelial Cells
Synonym: Cell, Dendritic
Synonym: Cells, Dendritic
Synonym: Dendritic Cell
Synonym: Dendritic cell
Synonym: Dendritic cells
Synonym: cell dendritic
Synonym: cell dendritics
Synonym: cells dendritic
Synonym: dendritic cell
Synonym: dendritic cells
Tree Number: T2.12.5
Tree Number: T2.3.1
database_cross_reference: CHV:0000003695
database_cross_reference: CSP:0432-1437
database_cross_reference: LCH_NW:sh91001535
database_cross_reference: MSH:D003713
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12583
database_cross_reference: NCI_NCI-GLOSS:CDR0000044948
database_cross_reference: SNM:T-01151
database_cross_reference: SNMI:T-01151
database_cross_reference: SNOMEDCT_US:9683001

Langerhans Cells
type: Class
subclass of: Dendritic Cells
PMOID: PMO:00000566
Subclass_of: Dendritic Cells
Synonym: Cell, Epidermal Dendritic
Synonym: Cells, Epidermal Dendritic
Synonym: Cells, Langerhans
Synonym: Dendritic Cell, Epidermal
Synonym: Dendritic Cells, Epidermal
Synonym: Epidermal Dendritic Cell
Synonym: Epidermal Dendritic Cells
Synonym: Langerhans Cell
Synonym: Langerhans cell
Synonym: Langerhans cells
Tree Number: T2.12.5.1
Tree Number: T2.3.1.1
database_cross_reference: CHV:0000007201
database_cross_reference: CSP:2716-1309
database_cross_reference: FMA:63072
database_cross_reference: LCH_NW:sh90001839
database_cross_reference: MSH:D007801
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12584
database_cross_reference: SNM:T-01153
database_cross_reference: SNMI:T-01153
database_cross_reference: SNOMEDCT_US:76322003
database_cross_reference: UWDA:63072

Blood Cells
type: Class
subclass of: Cell
PMOID: PMO:00000567
Subclass_of: Cell
Synonym: Blood Cell
Synonym: Blood Corpuscle
Synonym: Blood Corpuscles
Synonym: Blood cell
Synonym: Blood cell (body structure)
Synonym: Blood cell (cell)
Synonym: Blood cell, NOS
Synonym: Blood cells
Synonym: Cell, Blood
Synonym: Cells, Blood
Tree Number: T2.4
database_cross_reference: AOD:0000017446
database_cross_reference: AOD:0000027887
database_cross_reference: CHV:0000001985
database_cross_reference: CSP:0435-0475
database_cross_reference: FMA:62844
database_cross_reference: FMA:86697
database_cross_reference: LCH:U000613
database_cross_reference: LCH_NW:sh85014968
database_cross_reference: MEDLINEPLUS:6037
database_cross_reference: MEDLINEPLUS:6351
database_cross_reference: MSH:D001773
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12519
database_cross_reference: PSY:06220
database_cross_reference: SNM:T-0X100
database_cross_reference: SNMI:T-C2100
database_cross_reference: SNOMEDCT_US:63370004
database_cross_reference: UWDA:62844

Blood Platelets
type: Class
subclass of: Blood Cells
PMOID: PMO:00000568
Subclass_of: Blood Cells
Synonym: Bizzozero Corpuscle
Synonym: Bizzozero's corpuscle/cell
Synonym: Blood Platelet
Synonym: Blood platelet
Synonym: Blood platelets
Synonym: Deetjeen's body
Synonym: Deetjen Body
Synonym: Hayem's elementary corpuscle
Synonym: Marrow platelet
Synonym: PLATELET
Tree Number: T2.4.1
database_cross_reference: AOD:0000002647
database_cross_reference: AOD:0000023555
database_cross_reference: AOD:0000027914
database_cross_reference: AOD:0000027916
database_cross_reference: AOD:0000027918
database_cross_reference: AOD:0000027920
database_cross_reference: ATC:B05AX02
database_cross_reference: CCPSS:1013247
database_cross_reference: CCPSS:1013251
database_cross_reference: CHV:0000002006
database_cross_reference: CSP:0445-2127
database_cross_reference: FMA:62851
database_cross_reference: LCH:U000619
database_cross_reference: LCH_NW:sh85015006
database_cross_reference: LNC:LP14597-6
database_cross_reference: LNC:LP16772-3
database_cross_reference: LNC:LP70360-0
database_cross_reference: LNC:LP7631-7
database_cross_reference: LNC:MTHU002432
database_cross_reference: LNC:MTHU008063
database_cross_reference: MSH:D001792
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000206
database_cross_reference: NCI:C12520
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12520
database_cross_reference: NCI_NCI-GLOSS:CDR0000045840
database_cross_reference: NCI_NCI-GLOSS:CDR0000046614
database_cross_reference: PSY:06320
database_cross_reference: PSY:39100
database_cross_reference: RCD:X80Ve
database_cross_reference: SNM:T-06560
database_cross_reference: SNM:T-0X330
database_cross_reference: SNMI:T-C1560
database_cross_reference: SNOMEDCT_US:16378004
database_cross_reference: SNOMEDCT_US:256396005
database_cross_reference: SNOMEDCT_US:259727009
database_cross_reference: UWDA:62851

Erythrocytes
type: Class
subclass of: Blood Cells
subclass of: Erythroid Cells
PMOID: PMO:00000569
Subclass_of: Blood Cells
Subclass_of: Erythroid Cells
Synonym: Anucleate erythrocyte
Synonym: Blood Cell, Red
Synonym: Blood Cells, Red
Synonym: Blood Corpuscle, Red
Synonym: Blood Corpuscles
Synonym: Blood Corpuscles, Red
Synonym: Blood Erythrocyte
Synonym: Blood erythrocyte
Synonym: Blood erythrocytic cell
Synonym: Blood normocyte
Tree Number: T2.13.1
Tree Number: T2.4.2
database_cross_reference: AOD:0000007247
database_cross_reference: AOD:0000024260
database_cross_reference: AOD:0000027886
database_cross_reference: ATC:B05AX01
database_cross_reference: CCPSS:1011053
database_cross_reference: CHV:0000004629
database_cross_reference: CSP:0435-1425
database_cross_reference: FMA:62845
database_cross_reference: LCH:U001649
database_cross_reference: LCH_NW:sh85044747
database_cross_reference: LNC:LA12896-9
database_cross_reference: LNC:LP14304-7
database_cross_reference: LNC:LP16699-8
database_cross_reference: LNC:LP7536-8
database_cross_reference: LNC:MTHU001098
database_cross_reference: LNC:MTHU051574
database_cross_reference: MSH:D004912
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12521
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12521
database_cross_reference: NCI_NCI-GLOSS:CDR0000044401
database_cross_reference: NCI_NCI-GLOSS:CDR0000046124
database_cross_reference: NCI_NCI-GLOSS:CDR0000046425
database_cross_reference: PSY:17860
database_cross_reference: PSY:43467
database_cross_reference: RCD:X80Td
database_cross_reference: SNM:T-06160
database_cross_reference: SNM:T-0X110
database_cross_reference: SNM:T-0X120
database_cross_reference: SNMI:T-C1160
database_cross_reference: SNOMEDCT_US:256376002
database_cross_reference: SNOMEDCT_US:41898006
database_cross_reference: UWDA:62845

Erythrocytes, Abnormal
type: Class
subclass of: Erythrocytes
PMOID: PMO:00000570
Subclass_of: Erythrocytes
Synonym: 631-634 ABNORMAL RED BLOOD CELLS
Synonym: ABNORM ERYTHROCYTES
Synonym: ABNORMAL RED BLOOD CELLS
Synonym: Abnormal Erythrocyte
Synonym: Abnormal Erythrocytes
Synonym: Abnormal Red Blood Cell
Synonym: Abnormal erythrocyte
Synonym: Abnormal erythrocyte morphology
Synonym: Abnormal erythrocyte, NOS
Synonym: Abnormal red blood cell
Tree Number: T2.13.1.1
Tree Number: T2.4.2.2
database_cross_reference: CHV:0000004630
database_cross_reference: HPO:HP:0001877
database_cross_reference: MSH:D004913
database_cross_reference: MTH:U003408
database_cross_reference: NCI:C12522
database_cross_reference: SNMI:M-63100
database_cross_reference: SNOMEDCT_US:12222001
database_cross_reference: SNOMEDCT_US:397019006

Acanthocytes
type: Class
subclass of: Erythrocytes, Abnormal
PMOID: PMO:00000571
Subclass_of: Erythrocytes, Abnormal
Synonym: Acanthocyte
Synonym: Acanthocyte (cell)
Synonym: Acanthocyte (morphologic abnormality)
Synonym: Acanthocyte [dup] (morphologic abnormality)
Synonym: Acanthrocyte
Synonym: Crenated Red Blood Cell
Synonym: Crenated cell
Synonym: SPUR CELL
Synonym: Spiny prickle cell
Synonym: Spur Cell
Tree Number: T2.13.1.1.1
Tree Number: T2.4.2.2.1
database_cross_reference: CHV:0000000570
database_cross_reference: DXP:U003790
database_cross_reference: LNC:LA11190-8
database_cross_reference: LNC:LP17674-0
database_cross_reference: LNC:MTHU024320
database_cross_reference: MSH:D000050
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12523
database_cross_reference: OMIM:MTHU003553
database_cross_reference: RCD:X76u0
database_cross_reference: RCD:X80Tw
database_cross_reference: SNM:M-78210
database_cross_reference: SNM:M-78260
database_cross_reference: SNMI:M-63170
database_cross_reference: SNOMEDCT_US:250250008
database_cross_reference: SNOMEDCT_US:259685005
database_cross_reference: SNOMEDCT_US:63599005

Megaloblasts
type: Class
subclass of: Erythrocytes, Abnormal
PMOID: PMO:00000572
Subclass_of: Erythrocytes, Abnormal
Synonym: Megaloblast
Synonym: megaloblast
Synonym: megaloblasts
Tree Number: T2.13.1.1.2
Tree Number: T2.4.2.2.3
database_cross_reference: AOD:0000017451
database_cross_reference: CHV:0000007884
database_cross_reference: LNC:LP68315-8
database_cross_reference: LNC:MTHU032486
database_cross_reference: MSH:D008534
database_cross_reference: NCI:C12524

Spherocytes
type: Class
subclass of: Erythrocytes, Abnormal
PMOID: PMO:00000573
Subclass_of: Erythrocytes, Abnormal
Synonym: SPHEROCYTES
Synonym: Spherocyte
Synonym: Spherocyte (cell)
Synonym: Spherocyte (morphologic abnormality)
Synonym: Spherocytosis
Synonym: spherocyte
Synonym: spherocytes
Tree Number: T2.13.1.1.3
Tree Number: T2.4.2.2.4
database_cross_reference: CHV:0000011597
database_cross_reference: DXP:U003771
database_cross_reference: HPO:HP:0004444
database_cross_reference: LNC:LA11212-0
database_cross_reference: LNC:LP17717-7
database_cross_reference: LNC:MTHU024361
database_cross_reference: MSH:D013102
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12525
database_cross_reference: OMIM:MTHU048730
database_cross_reference: RCD:X80Tq
database_cross_reference: SNM:M-78330
database_cross_reference: SNMI:M-63280
database_cross_reference: SNOMEDCT_US:17235000
database_cross_reference: SNOMEDCT_US:259682008

Reticulocytes
type: Class
subclass of: Erythrocytes
subclass of: Bone Marrow Cells
PMOID: PMO:00000574
Subclass_of: Bone Marrow Cells
Subclass_of: Erythrocytes
Synonym: Blood reticulocyte
Synonym: Diffusely basophilic erythrocyte
Synonym: Marrow reticulocyte
Synonym: Polychromatophilic erythrocyte
Synonym: Reticulocyte
Synonym: Reticulocyte (cell)
Synonym: cells reticulocytes
Synonym: reticulocyte
Synonym: reticulocytes
Tree Number: T2.13.1.2
Tree Number: T2.4.2.3
Tree Number: T2.5.5
database_cross_reference: AOD:0000017459
database_cross_reference: CHV:0000010787
database_cross_reference: CSP:0435-3225
database_cross_reference: FMA:66785
database_cross_reference: LCH:U004103
database_cross_reference: LCH_NW:sh85113319
database_cross_reference: LNC:LP16487-8
database_cross_reference: LNC:MTHU004708
database_cross_reference: MSH:D012156
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12528
database_cross_reference: RCD:X80Te
database_cross_reference: SNM:T-06150
database_cross_reference: SNM:T-0X130
database_cross_reference: SNMI:T-C1150
database_cross_reference: SNOMEDCT_US:52802009
database_cross_reference: UWDA:66785

Hemocytes
type: Class
subclass of: Blood Cells
PMOID: PMO:00000575
Subclass_of: Blood Cells
Synonym: Hematocyte
Synonym: Hemocyte
Synonym: Hemocytes (cell)
Synonym: hemocyte
Synonym: hemocytes
Tree Number: T2.4.3
database_cross_reference: CHV:0000005976
database_cross_reference: FMA:83618
database_cross_reference: MSH:D006434
database_cross_reference: MTH:NOCODE

Leukocytes
type: Class
subclass of: Blood Cells
PMOID: PMO:00000576
Subclass_of: Blood Cells
Synonym: Blood Cell, White
Synonym: Blood Cells, White
Synonym: Blood Corpuscle, White
Synonym: Blood Corpuscles, White
Synonym: Blood leukocyte
Synonym: Corpuscle, White Blood
Synonym: Corpuscles, White Blood
Synonym: Leucocyte
Synonym: Leucocytes
Synonym: Leukocyte
Tree Number: T2.4.4
database_cross_reference: AOD:0000005918
database_cross_reference: AOD:0000027890
database_cross_reference: AOD:0000027891
database_cross_reference: CCPSS:1014703
database_cross_reference: CHV:0000007360
database_cross_reference: CSP:0435-4175
database_cross_reference: FMA:62852
database_cross_reference: LCH_NW:sh85076269
database_cross_reference: LNC:LA12894-4
database_cross_reference: LNC:LP14419-3
database_cross_reference: LNC:LP157588-7
database_cross_reference: LNC:LP20670-3
database_cross_reference: LNC:LP7720-8
database_cross_reference: LNC:MTHU001946
database_cross_reference: LNC:MTHU051577
database_cross_reference: MDR:10047854
database_cross_reference: MDR:10047955
database_cross_reference: MSH:D007962
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000080
database_cross_reference: MTH:U000173
database_cross_reference: NCI:C12529
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044430
database_cross_reference: NCI_NCI-GLOSS:CDR0000045993
database_cross_reference: NCI_NCI-GLOSS:CDR0000046067
database_cross_reference: NDDF:007472
database_cross_reference: PSY:28250
database_cross_reference: PSY:28270
database_cross_reference: PSY:56680
database_cross_reference: RCD:X80Uw
database_cross_reference: SNM:T-05500
database_cross_reference: SNM:T-06460
database_cross_reference: SNM:T-0X140
database_cross_reference: SNMI:T-C1460
database_cross_reference: SNOMEDCT_US:272170001
database_cross_reference: SNOMEDCT_US:52501007

Granulocytes
type: Class
subclass of: Leukocytes
subclass of: Bone Marrow Cells
subclass of: Myeloid Cells
PMOID: PMO:00000577
Subclass_of: Bone Marrow Cells
Subclass_of: Leukocytes
Subclass_of: Myeloid Cells
Synonym: Blood granulocytic cell
Synonym: Granular Leukocyte
Synonym: Granular Leukocytes
Synonym: Granular leucocyte
Synonym: Granular leukocyte
Synonym: Granulocyte
Synonym: Granulocyte (body structure)
Synonym: Granulocyte (cell)
Synonym: Granulocytic
Synonym: Granulocytic Cell
Tree Number: T2.20.2
Tree Number: T2.4.4.1
Tree Number: T2.5.1
database_cross_reference: AOD:0000017463
database_cross_reference: AOD:0000027892
database_cross_reference: CHV:0000005683
database_cross_reference: CSP:0435-6075
database_cross_reference: FMA:62854
database_cross_reference: LCH:U002035
database_cross_reference: LCH_NW:sh85056441
database_cross_reference: LNC:LP133971-4
database_cross_reference: LNC:LP18643-4
database_cross_reference: LNC:MTHU008674
database_cross_reference: MSH:D006098
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000172
database_cross_reference: NCI:C12530
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046374
database_cross_reference: NCI_NCI-GLOSS:CDR0000633912
database_cross_reference: RCD:X79co
database_cross_reference: SNM:T-0X150
database_cross_reference: SNMI:T-C1210
database_cross_reference: SNOMEDCT_US:256909001
database_cross_reference: SNOMEDCT_US:48791004

Basophils
type: Class
subclass of: Granulocytes
PMOID: PMO:00000578
Subclass_of: Granulocytes
Synonym: Basophil
Synonym: Basophil leukocyte
Synonym: Basophil, segmented
Synonym: Basophil, segmented (cell)
Synonym: Basophilic Granulocyte
Synonym: Basophilic Leukocyte
Synonym: Blood basophil
Synonym: Marrow basophil
Synonym: basophil
Synonym: basophilic granulocyte
Tree Number: T2.20.2.1
Tree Number: T2.4.4.1.1
database_cross_reference: AOD:0000017469
database_cross_reference: AOD:0000027901
database_cross_reference: AOD:0000027902
database_cross_reference: CHV:0000001728
database_cross_reference: CSP:0435-5125
database_cross_reference: FMA:62862
database_cross_reference: LCH_NW:sh85012133
database_cross_reference: LNC:LP14328-6
database_cross_reference: LNC:LP21273-5
database_cross_reference: LNC:MTHU012774
database_cross_reference: MSH:D001491
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000170
database_cross_reference: NCI:C12531
database_cross_reference: NCI_NCI-GLOSS:CDR0000046517
database_cross_reference: RCD:X80VQ
database_cross_reference: SNM:T-06440
database_cross_reference: SNM:T-0X180
database_cross_reference: SNMI:T-C1440
database_cross_reference: SNOMEDCT_US:30061004

Eosinophils
type: Class
subclass of: Granulocytes
PMOID: PMO:00000579
Subclass_of: Granulocytes
Synonym: Acidophilic Leukocyte
Synonym: Blood Eosinophil
Synonym: Blood eosinophil
Synonym: Blood eosinophils
Synonym: Eosinocyte
Synonym: Eosinophil
Synonym: Eosinophil leucocyte
Synonym: Eosinophil leukocyte
Synonym: Eosinophil, segmented
Synonym: Eosinophil, segmented (cell)
Tree Number: T2.20.2.2
Tree Number: T2.4.4.1.2
database_cross_reference: AOD:0000017468
database_cross_reference: AOD:0000027898
database_cross_reference: AOD:0000027899
database_cross_reference: AOD:0000027900
database_cross_reference: CHV:0000004532
database_cross_reference: CSP:0435-5600
database_cross_reference: FMA:62861
database_cross_reference: LCH_NW:sh85044242
database_cross_reference: LNC:LA12895-1
database_cross_reference: LNC:LP14539-8
database_cross_reference: LNC:LP28567-3
database_cross_reference: LNC:MTHU009211
database_cross_reference: MDR:10005503
database_cross_reference: MDR:10014963
database_cross_reference: MSH:D004804
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000171
database_cross_reference: NCI:C12532
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044844
database_cross_reference: RCD:X80VM
database_cross_reference: SNM:T-06340
database_cross_reference: SNM:T-0X170
database_cross_reference: SNMI:T-C1340
database_cross_reference: SNOMEDCT_US:14793004

Neutrophils
type: Class
subclass of: Granulocytes
subclass of: Phagocytes
PMOID: PMO:00000580
Subclass_of: Granulocytes
Subclass_of: Phagocytes
Synonym: Blood PMN
Synonym: Blood Segmented Neutrophil
Synonym: Blood neutrophil
Synonym: Blood neutrophils
Synonym: Blood segmented neutrophil
Synonym: Heterophile leucocyte
Synonym: Leukocyte, Polymorphonuclear
Synonym: Leukocytes, Polymorphonuclear
Synonym: Marrow neutrophil
Synonym: Neutrophil
Tree Number: T2.20.2.3
Tree Number: T2.27.3
Tree Number: T2.4.4.1.3
database_cross_reference: AOD:0000017464
database_cross_reference: AOD:0000017466
database_cross_reference: AOD:0000027893
database_cross_reference: AOD:0000027895
database_cross_reference: CCPSS:0004906
database_cross_reference: CHV:0000008680
database_cross_reference: CHV:0000022380
database_cross_reference: CHV:0000049043
database_cross_reference: CSP:0435-6550
database_cross_reference: FMA:62860
database_cross_reference: LCH:U003211
database_cross_reference: LCH_NW:sh85091230
database_cross_reference: LNC:LP14267-6
database_cross_reference: LNC:LP16686-5
database_cross_reference: LNC:LP17840-7
database_cross_reference: LNC:MTHU006207
database_cross_reference: LNC:MTHU009212
database_cross_reference: LNC:MTHU044811
database_cross_reference: MDR:10005674
database_cross_reference: MDR:10029380
database_cross_reference: MSH:D009504
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000178
database_cross_reference: NCI:C12533
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046270
database_cross_reference: NCI_NCI-GLOSS:CDR0000633913
database_cross_reference: NCI_NCI-GLOSS:CDR0000633963
database_cross_reference: RCD:X80Ux
database_cross_reference: SNM:T-06260
database_cross_reference: SNM:T-0X160
database_cross_reference: SNMI:T-C1260
database_cross_reference: SNOMEDCT_US:116712007
database_cross_reference: SNOMEDCT_US:259710001
database_cross_reference: SNOMEDCT_US:80153006

Leukocytes, Mononuclear
type: Class
subclass of: Leukocytes
PMOID: PMO:00000581
Subclass_of: Leukocytes
Synonym: Agranular leukocyte
Synonym: Agranulocyte
Synonym: Leukocyte, Mononuclear
Synonym: Mononuclear Leukocyte
Synonym: Mononuclear Leukocytes
Synonym: Mononuclear leukocyte
Synonym: Non-Granular Leukocyte
Synonym: Non-Granular Leukocytes
Synonym: Nongranular leukocyte
Synonym: agranular leukocyte
Tree Number: T2.4.4.2
database_cross_reference: AOD:0000017471
database_cross_reference: AOD:0000027904
database_cross_reference: AOD:0000027906
database_cross_reference: CHV:0000007361
database_cross_reference: FMA:62855
database_cross_reference: MSH:D007963
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12534
database_cross_reference: NCI_NCI-GLOSS:CDR0000046207

Lymphocytes
type: Class
subclass of: Leukocytes, Mononuclear
PMOID: PMO:00000582
Subclass_of: Leukocytes, Mononuclear
Synonym: Blood lymphocyte
Synonym: Blood lymphocytic cell
Synonym: Lymph Cell
Synonym: Lymphocyte
Synonym: Lymphocyte (cell)
Synonym: Lymphocyte, NOS
Synonym: Lymphocytic
Synonym: Lymphocytic cell
Synonym: Lymphocytic cell, NOS
Synonym: Marrow lymphocyte
Tree Number: T2.4.4.2.1
database_cross_reference: AOD:0000002684
database_cross_reference: AOD:0000027925
database_cross_reference: CHV:0000007609
database_cross_reference: CSP:0435-7500
database_cross_reference: FMA:62863
database_cross_reference: LCH:U002760
database_cross_reference: LCH_NW:sh85079147
database_cross_reference: LNC:LP14540-6
database_cross_reference: LNC:LP30914-3
database_cross_reference: LNC:MTHU004645
database_cross_reference: MDR:10025263
database_cross_reference: MSH:D008214
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000176
database_cross_reference: NCI:C12535
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000045765
database_cross_reference: PSY:29060
database_cross_reference: RCD:X80V7
database_cross_reference: SNM:T-05230
database_cross_reference: SNM:T-06660
database_cross_reference: SNM:T-0X210
database_cross_reference: SNM:T-0X220
database_cross_reference: SNMI:T-C0230
database_cross_reference: SNOMEDCT_US:56972008

Precursor Cells, B-Lymphoid
type: Class
subclass of: Lymphoid Progenitor Cells
PMOID: PMO:00000583
Subclass_of: Lymphoid Progenitor Cells
Synonym: B Lymphoid Precursor Cells
Synonym: B-Cell, Immature
Synonym: B-Cell, Transitional
Synonym: B-Cells, Immature
Synonym: B-Cells, Transitional
Synonym: B-Lymphocyte, Immature
Synonym: B-Lymphocyte, Transitional
Synonym: B-Lymphocytes, Immature
Synonym: B-Lymphocytes, Transitional
Synonym: B-Lymphoid Precursor Cell
Tree Number: T2.34.2.3.1
Tree Number: T2.5.2.2.1
database_cross_reference: MEDCIN:12036
database_cross_reference: MSH:D054448
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32766

Precursor Cells, T-Lymphoid
type: Class
subclass of: Lymphoid Progenitor Cells
PMOID: PMO:00000599
Subclass_of: Lymphoid Progenitor Cells
Synonym: Cell, T-Lymphoid Precursor
Synonym: Cells, T-Lymphoid Precursor
Synonym: Precursor Cell, T-Lymphoid
Synonym: Precursor Cells, T Lymphoid
Synonym: Precursor, T-Cell
Synonym: Precursors, T-Cell
Synonym: T Cell Precursors
Synonym: T-Cell Precursor
Synonym: T-Cell Precursors
Synonym: T-Lymphoid Precursor Cell
Tree Number: T2.34.2.3.2
Tree Number: T2.5.2.2.2
database_cross_reference: MSH:D054504

Thymocytes
type: Class
subclass of: Cell
PMOID: PMO:00000600
Subclass_of: Cell
Synonym: Thymic lymphocyte
Synonym: Thymic lymphocyte (cell)
Synonym: Thymocyte
Synonym: thymocyte
Synonym: thymocytes
Tree Number: T2.35
database_cross_reference: AOD:0000017491
database_cross_reference: CHV:0000049345
database_cross_reference: CSP:0435-8450
database_cross_reference: FMA:72202
database_cross_reference: MSH:D060168
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12994
database_cross_reference: NCI_NCI-GLOSS:CDR0000633949
database_cross_reference: SNM:T-98070
database_cross_reference: SNMI:T-C8070
database_cross_reference: SNOMEDCT_US:39105001

Monocytes
type: Class
subclass of: Leukocytes, Mononuclear
subclass of: Bone Marrow Cells
subclass of: Myeloid Cells
subclass of: Phagocytes
PMOID: PMO:00000604
Subclass_of: Bone Marrow Cells
Subclass_of: Leukocytes, Mononuclear
Subclass_of: Myeloid Cells
Subclass_of: Phagocytes
Synonym: Blood monocyte
Synonym: Blood monocytes
Synonym: MONOCYTE
Synonym: Marrow monocyte
Synonym: Monocyte
Synonym: Monocyte (cell)
Synonym: Monocyte, NOS
Synonym: Monocytic
Synonym: blood monocytes
Synonym: monocyte
Tree Number: T2.20.4
Tree Number: T2.27.2
Tree Number: T2.4.4.2.2
Tree Number: T2.5.4
database_cross_reference: AOD:0000017472
database_cross_reference: CHV:0000008236
database_cross_reference: CSP:0435-8925
database_cross_reference: FMA:62864
database_cross_reference: LCH:U003015
database_cross_reference: LCH_NW:sh85086902
database_cross_reference: LNC:LP14313-8
database_cross_reference: LNC:LP32104-9
database_cross_reference: LNC:MTHU012776
database_cross_reference: MDR:10005667
database_cross_reference: MDR:10027884
database_cross_reference: MSH:D009000
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000177
database_cross_reference: NCI:C12547
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12547
database_cross_reference: NCI_NCI-GLOSS:CDR0000046282
database_cross_reference: RCD:X80VJ
database_cross_reference: SNM:T-05420
database_cross_reference: SNM:T-06700
database_cross_reference: SNM:T-0X290
database_cross_reference: SNMI:T-C1700
database_cross_reference: SNOMEDCT_US:55918008

Monocytes, Activated Killer
type: Class
subclass of: Monocytes
PMOID: PMO:00000605
Subclass_of: Monocytes
Synonym: AKM
Synonym: Activated Killer Monocyte
Synonym: Activated Killer Monocytes
Synonym: Killer Monocyte, Activated
Synonym: Killer Monocytes, Activated
Synonym: Monocyte, Activated Killer
Tree Number: T2.20.4.1
Tree Number: T2.27.2.1
database_cross_reference: MSH:D016260
database_cross_reference: NCI:C12548

Cytokine-Induced Killer Cells
type: Class
subclass of: Leukocytes, Mononuclear
subclass of: Cells, Cultured
PMOID: PMO:00000606
Subclass_of: Cells, Cultured
Subclass_of: Leukocytes, Mononuclear
Synonym: CIK
Synonym: CIK Cell
Synonym: CIK Cells
Synonym: Cytokine Induced Killer Cells
Synonym: Cytokine-Induced Killer Cell
Synonym: Killer Cell, Cytokine-Induced
Synonym: Killer Cells, Cytokine-Induced
Tree Number: T2.4.4.2.3
Tree Number: T2.6.6
database_cross_reference: MSH:D055612
database_cross_reference: NCI:C71757

Bone Marrow Cells
type: Class
subclass of: Cell
PMOID: PMO:00000607
Subclass_of: Cell
Synonym: Bone Marrow Blood-Forming Cell
Synonym: Bone Marrow Blood-Forming Cells
Synonym: Bone Marrow Cell
Synonym: Bone marrow cell
Synonym: Bone marrow cells
Synonym: Cell, Bone Marrow
Synonym: Cells, Bone Marrow
Synonym: Marrow Cell, Bone
Synonym: Marrow Cells, Bone
Synonym: bone cell marrow
Tree Number: T2.5
database_cross_reference: CHV:0000002073
database_cross_reference: FMA:83621
database_cross_reference: LCH_NW:sh85081545
database_cross_reference: MSH:D001854
database_cross_reference: NCI:C12550

Granulocyte Precursor Cells
type: Class
subclass of: Granulocytes
subclass of: Granulocyte-Macrophage Progenitor Cells
PMOID: PMO:00000608
Subclass_of: Granulocyte-Macrophage Progenitor Cells
Subclass_of: Granulocytes
Synonym: Cell, Granulocyte Precursor
Synonym: Cell, Granulocytic Precursor
Synonym: Cells, Granulocyte Precursor
Synonym: Cells, Granulocytic Precursor
Synonym: Granulocyte Precursor Cell
Synonym: Granulocytic Precursor Cell
Synonym: Granulocytic Precursor Cells
Synonym: Precursor Cell, Granulocyte
Synonym: Precursor Cell, Granulocytic
Synonym: Precursor Cells, Granulocyte
Tree Number: T2.20.2.4
Tree Number: T2.20.5.1.1
Tree Number: T2.5.1.1
database_cross_reference: MSH:D042381

Hematopoietic Stem Cells
type: Class
subclass of: Bone Marrow Cells
subclass of: Stem Cells
PMOID: PMO:00000609
Subclass_of: Bone Marrow Cells
Subclass_of: Stem Cells
Synonym: Blood-forming stem cell
Synonym: Cell, Hematopoietic Progenitor
Synonym: Cell, Hematopoietic Stem
Synonym: Cells, Hematopoietic Progenitor
Synonym: Cells, Hematopoietic Stem
Synonym: Ferrata cell
Synonym: HSC
Synonym: HSCs
Synonym: Haematopoietic stem cell
Synonym: Hematohistioblast
Tree Number: T2.34.2
Tree Number: T2.5.2
database_cross_reference: AOD:0000017480
database_cross_reference: CHV:0000005960
database_cross_reference: CHV:0000043661
database_cross_reference: CSP:0435-3857
database_cross_reference: CSP:4009-0065
database_cross_reference: FMA:86475
database_cross_reference: LCH:U002134
database_cross_reference: LCH_NW:sh85060138
database_cross_reference: LNC:LP149847-8
database_cross_reference: LNC:LP193444-9
database_cross_reference: LNC:MTHU044488
database_cross_reference: LNC:MTHU052722
database_cross_reference: MSH:D006412
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12551
database_cross_reference: NCI:TCGA
database_cross_reference: NDFRT:N0000184313
database_cross_reference: SNOMEDCT_US:418318001

Myeloid Progenitor Cells
type: Class
subclass of: Hematopoietic Stem Cells
subclass of: Myeloid Cells
PMOID: PMO:00000610
Subclass_of: Hematopoietic Stem Cells
Subclass_of: Myeloid Cells
Synonym: Bone Marrow Myeloid Stem Cell
Synonym: Cell, Myeloid Progenitor
Synonym: Cell, Myeloid Stem
Synonym: Cells, Myeloid Progenitor
Synonym: Cells, Myeloid Stem
Synonym: Myeloid Progenitor Cell
Synonym: Myeloid Stem Cell
Synonym: Myeloid Stem Cells
Synonym: Myeloid cell
Synonym: Myeloid stem cell
Tree Number: T2.20.5
Tree Number: T2.34.2.2
Tree Number: T2.5.2.1
database_cross_reference: CHV:0000041656
database_cross_reference: CSP:0435-9400
database_cross_reference: FMA:70339
database_cross_reference: MSH:D023461
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12552

Granulocyte-Macrophage Progenitor Cells
type: Class
subclass of: Myeloid Progenitor Cells
PMOID: PMO:00000611
Subclass_of: Myeloid Progenitor Cells
Synonym: Cell, Granulocyte-Macrophage Progenitor
Synonym: Cells, Granulocyte-Macrophage Progenitor
Synonym: Granulocyte Macrophage Progenitor Cell
Synonym: Granulocyte Macrophage Progenitor Cells
Synonym: Granulocyte Macrophage Progenitors
Synonym: Granulocyte-Macrophage Progenitor
Synonym: Granulocyte-Macrophage Progenitor Cell
Synonym: Granulocyte-Macrophage Progenitors
Synonym: Progenitor Cell, Granulocyte-Macrophage
Synonym: Progenitor Cells, Granulocyte Macrophage
Tree Number: T2.20.5.1
Tree Number: T2.34.2.2.1
Tree Number: T2.5.2.1.1
database_cross_reference: MSH:D055014

Monocyte-Macrophage Precursor Cells
type: Class
subclass of: Monocytes
subclass of: Granulocyte-Macrophage Progenitor Cells
subclass of: Macrophages
PMOID: PMO:00000612
Subclass_of: Granulocyte-Macrophage Progenitor Cells
Subclass_of: Macrophages
Subclass_of: Monocytes
Synonym: Cell, Monocyte-Macrophage Precursor
Synonym: Cells, Monocyte-Macrophage Precursor
Synonym: Monocyte Macrophage Precursor Cells
Synonym: Monocyte-Macrophage Precursor Cell
Synonym: Precursor Cell, Monocyte-Macrophage
Synonym: Precursor Cells, Monocyte-Macrophage
Tree Number: T2.20.3.10
Tree Number: T2.20.4.2
Tree Number: T2.20.5.1.2
Tree Number: T2.5.4.1
database_cross_reference: MSH:D055017

Megakaryocyte-Erythroid Progenitor Cells
type: Class
subclass of: Myeloid Progenitor Cells
PMOID: PMO:00000613
Subclass_of: Myeloid Progenitor Cells
Synonym: Cell, Megakaryocyte-Erythroid Progenitor
Synonym: Cells, Megakaryocyte-Erythroid Progenitor
Synonym: Megakaryocyte Erythrocyte Progenitors
Synonym: Megakaryocyte Erythroid Progenitor Cells
Synonym: Megakaryocyte Erythroid Progenitors
Synonym: Megakaryocyte-Erythrocyte Progenitor
Synonym: Megakaryocyte-Erythrocyte Progenitors
Synonym: Megakaryocyte-Erythroid Progenitor
Synonym: Megakaryocyte-Erythroid Progenitor Cell
Synonym: Megakaryocyte-Erythroid Progenitors
Tree Number: T2.34.2.2.2
Tree Number: T2.5.2.1.2
database_cross_reference: MSH:D055015

Erythroid Precursor Cells
type: Class
subclass of: Erythrocytes
PMOID: PMO:00000614
Subclass_of: Erythrocytes
Synonym: Cell, Erythroid Precursor
Synonym: Cells, Erythroid Precursor
Synonym: Erythroid Precursor Cell
Synonym: Erythroid precursor cell
Synonym: Erythroid precursor cell (body structure)
Synonym: Erythroid precursor cell (cell)
Synonym: Precursor Cell, Erythroid
Synonym: Precursor Cells, Erythroid
Synonym: Red blood cell precursor
Synonym: Red blood cell precursor (body structure)
Tree Number: T2.13.1.3
database_cross_reference: AOD:0000017450
database_cross_reference: CHV:0000043660
database_cross_reference: FMA:84774
database_cross_reference: MSH:D015672
database_cross_reference: MTH:NOCODE
database_cross_reference: RCD:XaA1Q
database_cross_reference: SNOMEDCT_US:127912006
database_cross_reference: SNOMEDCT_US:304601009

Erythroblasts
type: Class
subclass of: Erythroid Precursor Cells
PMOID: PMO:00000615
Subclass_of: Erythroid Precursor Cells
Synonym: Erythroblast
Synonym: Erythroblast (cell)
Synonym: Erythrocyte, Nucleated
Synonym: Erythrocytes, Nucleated
Synonym: Erythrocytes.nucleated
Synonym: NRBC - Nucleated red blood cell present
Synonym: NUCLEATED RED BLOOD CELLS
Synonym: NUCLEATED RED CELLS
Synonym: Normoblast
Synonym: Nucleated Erythrocyte
Tree Number: T2.13.1.3.1
database_cross_reference: CHV:0000004621
database_cross_reference: CSP:0435-0950
database_cross_reference: DXP:NOCODE
database_cross_reference: DXP:U002895
database_cross_reference: FMA:83504
database_cross_reference: LNC:LP14464-9
database_cross_reference: LNC:MTHU004246
database_cross_reference: MDR:10029825
database_cross_reference: MDR:10053106
database_cross_reference: MEDCIN:12048
database_cross_reference: MEDCIN:12056
database_cross_reference: MSH:D004900
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12527
database_cross_reference: NCI:C73125
database_cross_reference: RCD:X80Th
database_cross_reference: SNM:T-06110
database_cross_reference: SNMI:T-C1104
database_cross_reference: SNMI:T-C1110
database_cross_reference: SNMI:T-C1140
database_cross_reference: SNOMEDCT_US:29208003
database_cross_reference: SNOMEDCT_US:84227004

Lymphoid Progenitor Cells
type: Class
subclass of: Hematopoietic Stem Cells
PMOID: PMO:00000617
Subclass_of: Hematopoietic Stem Cells
Synonym: Cell, Lymphoid Progenitor
Synonym: Cell, Lymphoid Stem
Synonym: Cells, Lymphoid Progenitor
Synonym: Cells, Lymphoid Stem
Synonym: Lymphoid Progenitor Cell
Synonym: Lymphoid Stem Cell
Synonym: Lymphoid Stem Cells
Synonym: Lymphoid stem cell
Synonym: Progenitor Cell, Lymphoid
Synonym: Progenitor Cells, Lymphoid
Tree Number: T2.34.2.3
Tree Number: T2.5.2.2
database_cross_reference: FMA:70338
database_cross_reference: MSH:D054503

Megakaryocytes
type: Class
subclass of: Bone Marrow Cells
PMOID: PMO:00000618
Subclass_of: Bone Marrow Cells
Synonym: Blood megakaryocyte
Synonym: Megakaryocyte
Synonym: Megakaryocyte (cell)
Synonym: Megakaryocyte (substance)
Synonym: Megakaryocyte, NOS
Synonym: Megakaryocytic
Synonym: Megalokaryocyte
Synonym: megacaryocyte
Synonym: megakaryocyte
Synonym: megakaryocytes
Tree Number: T2.5.3
database_cross_reference: AOD:0000017476
database_cross_reference: AOD:0000027911
database_cross_reference: AOD:0000027912
database_cross_reference: AOD:0000027913
database_cross_reference: CHV:0000007883
database_cross_reference: CHV:0000057837
database_cross_reference: CSP:0432-7052
database_cross_reference: FMA:83555
database_cross_reference: LCH:U002883
database_cross_reference: LCH_NW:sh85083275
database_cross_reference: MSH:D008533
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12553
database_cross_reference: RCD:X80Vf
database_cross_reference: SNM:T-06540
database_cross_reference: SNM:T-0X320
database_cross_reference: SNMI:T-C1540
database_cross_reference: SNOMEDCT_US:23592000
database_cross_reference: SNOMEDCT_US:259728004

Endothelial Progenitor Cells
type: Class
subclass of: Bone Marrow Cells
subclass of: Endothelial Cells
PMOID: PMO:00000619
Subclass_of: Bone Marrow Cells
Subclass_of: Endothelial Cells
Synonym: Circulating Endothelial Progenitor Cells
Synonym: EPC
Synonym: Endothelial Progenitor Cell
Synonym: Endothelial Stem Cell
Synonym: Progenitor Cell, Endothelial
Synonym: Progenitor Cells, Endothelial
Tree Number: T2.12.27.4
Tree Number: T2.5.6
database_cross_reference: MSH:D066026
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124145

Cells, Cultured
type: Class
subclass of: Cell
PMOID: PMO:00000620
Subclass_of: Cell
Synonym: Cell Strain
Synonym: Cell, Cultured
Synonym: Cultured Cell
Synonym: Cultured Cells
Synonym: Cultured cells
Synonym: Cultured cells (substance)
Synonym: cell culturing
Synonym: cells cultured
Synonym: cultured cell
Synonym: cultured cells
Tree Number: T2.6
database_cross_reference: CHV:0000002604
database_cross_reference: MSH:D002478
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45382
database_cross_reference: NCI_NCI-GLOSS:CDR0000044017
database_cross_reference: SNOMEDCT_US:702451000

Cell Line
type: Class
subclass of: Cells, Cultured
PMOID: PMO:00000621
Subclass_of: Cells, Cultured
Synonym: Cell Lines
Synonym: Cell lines
Synonym: Cultured Cell Line
Synonym: Line, Cell
Synonym: Lines, Cell
Synonym: cell line
Synonym: cell lines
Synonym: cell lining
Synonym: cells line
Synonym: cells lines
Tree Number: T2.6.1
database_cross_reference: AOD:0000016692
database_cross_reference: CHV:0000002591
database_cross_reference: CSP:4000-0369
database_cross_reference: LCH:U000870
database_cross_reference: LCH_NW:sh85021651
database_cross_reference: MSH:D002460
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16403
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044016
database_cross_reference: NCI_NCI-GLOSS:CDR0000044017

Cell Line, Transformed
type: Class
subclass of: Cell Line
PMOID: PMO:00000622
Subclass_of: Cell Line
Synonym: Cell Lines, Transformed
Synonym: Transformed Cell Line
Synonym: Transformed Cell Lines
Tree Number: T2.6.1.1
database_cross_reference: MSH:D002461

RAW 264.7 Cells
type: Class
subclass of: Cell Line, Transformed
subclass of: Macrophages
PMOID: PMO:00000623
Subclass_of: Cell Line, Transformed
Subclass_of: Macrophages
Synonym: 264.7 Cell, RAW
Synonym: 264.7 Cells, RAW
Synonym: Cell, RAW 264.7
Synonym: Cells, RAW 264.7
Synonym: RAW 264.7 Cell
Synonym: RAW 264.7 Cell Line
Tree Number: T2.27.1.1
Tree Number: T2.6.1.1.1
database_cross_reference: MSH:D000067996

COS Cells
type: Class
subclass of: Cell Line, Transformed
subclass of: Fibroblasts
PMOID: PMO:00000624
Subclass_of: Cell Line, Transformed
Subclass_of: Fibroblasts
Synonym: COS Cell
Synonym: COS-1
Synonym: Cell, COS
Synonym: Cells, COS
Synonym: cos cell
Synonym: cos cells
Tree Number: T2.10.3.4
Tree Number: T2.6.1.1.2
database_cross_reference: CHV:0000031875
database_cross_reference: MSH:D019556
database_cross_reference: NCI:C17968

HEK293 Cells
type: Class
subclass of: Cell Line, Transformed
subclass of: Epithelial Cells
PMOID: PMO:00000625
Subclass_of: Cell Line, Transformed
Subclass_of: Epithelial Cells
Synonym: 293 Cell, HEK
Synonym: 293 Cells, HEK
Synonym: 293T Cell
Synonym: 293T Cells
Synonym: Cell, 293T
Synonym: Cell, HEK 293
Synonym: Cell, HEK293
Synonym: Cells, 293T
Synonym: Cells, HEK 293
Synonym: Cells, HEK293
Tree Number: T2.12.37
Tree Number: T2.6.1.1.3
database_cross_reference: MSH:D057809

L Cells (Cell Line)
type: Class
subclass of: Cell Line
subclass of: Fibroblasts
PMOID: PMO:00000626
Subclass_of: Cell Line
Subclass_of: Fibroblasts
Synonym: Cell, L (Cell Line)
Synonym: Cells, L (Cell Line)
Synonym: L Cell (Cell Line)
Synonym: L cell
Synonym: cell l
Synonym: l cells (cell line)
Tree Number: T2.10.3.2
Tree Number: T2.6.1.2
database_cross_reference: CHV:0000007146
database_cross_reference: CSP:2027-3178
database_cross_reference: MSH:D007739

Vero Cells
type: Class
subclass of: Cell Line
subclass of: Epithelial Cells
PMOID: PMO:00000627
Subclass_of: Cell Line
Subclass_of: Epithelial Cells
Synonym: Cell, Vero
Synonym: Cells, Vero
Synonym: Vero Cell
Synonym: Vero cell
Synonym: cells vero
Synonym: vero cell
Synonym: vero cells
Tree Number: T2.12.14
Tree Number: T2.6.1.3
database_cross_reference: CHV:0000012963
database_cross_reference: CSP:4008-0101
database_cross_reference: MSH:D014709

CHO Cells
type: Class
subclass of: Cell Line
subclass of: Epithelial Cells
PMOID: PMO:00000628
Subclass_of: Cell Line
Subclass_of: Epithelial Cells
Tree Number: T2.12.16
Tree Number: T2.6.1.4

3T3 Cells
type: Class
subclass of: Cell Line
subclass of: Fibroblasts
PMOID: PMO:00000629
Subclass_of: Cell Line
Subclass_of: Fibroblasts
Synonym: 3T3 Cell
Synonym: 3T3 cell
Synonym: Cell, 3T3
Synonym: Cells, 3T3
Synonym: T AAA A CELLS 03 03
Tree Number: T2.10.3.3
Tree Number: T2.6.1.5
database_cross_reference: AOD:0000016699
database_cross_reference: CSP:4001-0092
database_cross_reference: MSH:D016475

NIH 3T3 Cells
type: Class
subclass of: 3T3 Cells
PMOID: PMO:00000630
Subclass_of: 3T3 Cells
Synonym: 3T3 Cell, NIH
Synonym: 3T3 Cells, NIH
Synonym: Cell, NIH 3T3
Synonym: Cell, NIH-3T3
Synonym: Cells, NIH 3T3
Synonym: Cells, NIH-3T3
Synonym: NIH 3T3 Cell
Synonym: NIH T A CELLS 03 03
Synonym: NIH-3T3 Cell
Synonym: NIH-3T3 Cells
Tree Number: T2.10.3.3.1
Tree Number: T2.6.1.5.1
database_cross_reference: MSH:D041681
database_cross_reference: NCI:C17422

Swiss 3T3 Cells
type: Class
subclass of: 3T3 Cells
PMOID: PMO:00000631
Subclass_of: 3T3 Cells
Synonym: 3T3 Cells, Swiss
Synonym: 3T3 Swiss Albino
Synonym: 3T3-Swiss Albino
Synonym: Cells, Swiss 3T3
Synonym: SWISS T A CELLS 03 03
Tree Number: T2.10.3.3.2
Tree Number: T2.6.1.5.2
database_cross_reference: MSH:D041701

BALB 3T3 Cells
type: Class
subclass of: 3T3 Cells
PMOID: PMO:00000633
Subclass_of: 3T3 Cells
Synonym: 3T3 Cell, BALB
Synonym: 3T3 Cell, BALB-c
Synonym: 3T3 Cells, BALB
Synonym: 3T3 Cells, BALB-c
Synonym: BALB 3T3 Cell
Synonym: BALB T A CELLS 03 03
Synonym: BALB c 3T3 Cells
Synonym: BALB-3T3 Cell
Synonym: BALB-3T3 Cells
Synonym: BALB-c 3T3 Cell
Tree Number: T2.10.3.3.3
Tree Number: T2.6.1.5.3
database_cross_reference: MSH:D041702

LLC-PK1 Cells
type: Class
subclass of: Cell Line
subclass of: Epithelial Cells
PMOID: PMO:00000634
Subclass_of: Cell Line
Subclass_of: Epithelial Cells
Synonym: Cell, LLC-PK1
Synonym: Cells, LLC-PK1
Synonym: LLC PK1 Cells
Synonym: LLC-PK1 Cell
Tree Number: T2.12.17
Tree Number: T2.6.1.6
database_cross_reference: MSH:D018374

Cell Line, Tumor
type: Class
subclass of: Cell Line
subclass of: Tumor Cells, Cultured
PMOID: PMO:00000635
Subclass_of: Cell Line
Subclass_of: Tumor Cells, Cultured
Synonym: Cell Lines, Tumor
Synonym: Line, Tumor Cell
Synonym: Lines, Tumor Cell
Synonym: Tumor Cell Line
Synonym: Tumor Cell Lines
Synonym: tumor cell line
Synonym: tumor cell lines
Tree Number: T2.6.1.7
Tree Number: T2.6.4.1
database_cross_reference: AOD:0000016715
database_cross_reference: CHV:0000015815
database_cross_reference: MSH:D045744
database_cross_reference: NCI:C20313

A549 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Epithelial Cells
PMOID: PMO:00000636
Subclass_of: Cell Line, Tumor
Subclass_of: Epithelial Cells
Synonym: A549 Cell
Synonym: A549 Cell Line
Synonym: A549 Cell Lines
Synonym: Cell Line, A549
Synonym: Cell Lines, A549
Synonym: Cell, A549
Synonym: Cells, A549
Tree Number: T2.12.1
Tree Number: T2.6.1.7.1
Tree Number: T2.6.4.1.1
database_cross_reference: MSH:D000072283

THP-1 Cells
type: Class
subclass of: Cell Line, Tumor
PMOID: PMO:00000637
Subclass_of: Cell Line, Tumor
Tree Number: T2.6.1.7.2
Tree Number: T2.6.4.1.2

HeLa Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Epithelial Cells
PMOID: PMO:00000638
Subclass_of: Cell Line, Tumor
Subclass_of: Epithelial Cells
Synonym: Cell, HeLa
Synonym: Cells, HeLa
Synonym: HeLa
Synonym: HeLa Cell
Synonym: HeLa cell
Synonym: HeLa cells
Synonym: hela cell
Synonym: hela cells
Tree Number: T2.12.7
Tree Number: T2.6.1.7.3
Tree Number: T2.6.4.1.3
database_cross_reference: AOD:0000016717
database_cross_reference: CHV:0000005919
database_cross_reference: CSP:2027-2640
database_cross_reference: LCH:U002086
database_cross_reference: LCH_NW:sh85059978
database_cross_reference: MSH:D006367
database_cross_reference: NCI:C20226

KB Cells
type: Class
subclass of: HeLa Cells
PMOID: PMO:00000639
Subclass_of: HeLa Cells
Synonym: Cell, HeLa-KB
Synonym: Cell, KB
Synonym: Cells, HeLa-KB
Synonym: Cells, KB
Synonym: HeLa KB Cells
Synonym: HeLa-KB Cell
Synonym: HeLa-KB Cells
Synonym: KB Cell
Synonym: KB cell
Tree Number: T2.12.7.1
database_cross_reference: CSP:2935-5475
database_cross_reference: MSH:D007624

PC12 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Chromaffin Cells
PMOID: PMO:00000640
Subclass_of: Cell Line, Tumor
Subclass_of: Chromaffin Cells
Synonym: Cell Line, Pheochromocytoma
Synonym: Cell Lines, Pheochromocytoma
Synonym: PC A 012 CELLS
Synonym: PC-12
Synonym: PC12 Cell
Synonym: PC12 cell
Synonym: Pheochromocytoma 12 Cell Line
Synonym: Pheochromocytoma Cell Line
Synonym: Pheochromocytoma Cell Lines
Synonym: pc12 cell
Tree Number: T2.6.1.7.4
Tree Number: T2.6.4.1.4
Tree Number: T2.9.1
database_cross_reference: CHV:0000015524
database_cross_reference: CSP:4001-0103
database_cross_reference: MSH:D016716
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17435

HL-60 Cells
type: Class
subclass of: Granulocyte Precursor Cells
subclass of: Cell Line, Tumor
PMOID: PMO:00000641
Subclass_of: Cell Line, Tumor
Subclass_of: Granulocyte Precursor Cells
Synonym: Cell, HL60
Synonym: Cells, HL60
Synonym: HL 60 Cells
Synonym: HL CELLS 060
Synonym: HL-60 Cell
Synonym: HL60 Cell
Synonym: HL60 Cells
Synonym: hl-60 cells
Synonym: hl60 cells
Tree Number: T2.20.2.4.1
Tree Number: T2.6.1.7.5
Tree Number: T2.6.4.1.5
database_cross_reference: CHV:0000027639
database_cross_reference: MSH:D018922

Caco-2 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Epithelial Cells
PMOID: PMO:00000642
Subclass_of: Cell Line, Tumor
Subclass_of: Epithelial Cells
Synonym: CACO CELLS 002
Synonym: Caco 2 Cells
Synonym: Caco-2 Cell
Synonym: Cell, Caco-2
Synonym: Cells, Caco-2
Synonym: caco 2 cell
Synonym: caco 2 cells
Synonym: caco-2 cell
Tree Number: T2.12.19
Tree Number: T2.6.1.7.6
Tree Number: T2.6.4.1.6
database_cross_reference: CHV:0000027645
database_cross_reference: MSH:D018938
database_cross_reference: NCI:C12912

HT29 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Epithelial Cells
PMOID: PMO:00000643
Subclass_of: Cell Line, Tumor
Subclass_of: Epithelial Cells
Synonym: Cell, HT-29
Synonym: Cell, HT29
Synonym: Cells, HT-29
Synonym: Cells, HT29
Synonym: HT 29 CELLS
Synonym: HT 29 Cells
Synonym: HT-29
Synonym: HT-29 Cell
Synonym: HT-29 Cells
Synonym: HT29
Tree Number: T2.12.20
Tree Number: T2.6.1.7.7
Tree Number: T2.6.4.1.7
database_cross_reference: CHV:0000027678
database_cross_reference: MSH:D019073
database_cross_reference: NCI:C17896

Jurkat Cells
type: Class
subclass of: Cell Line, Tumor
PMOID: PMO:00000644
Subclass_of: Cell Line, Tumor
Synonym: Cell, Jurkat
Synonym: Cells, Jurkat
Synonym: Jurkat Cell
Synonym: Jurkat cell
Synonym: jurkat cells
Tree Number: T2.6.1.7.8
Tree Number: T2.6.4.1.8
database_cross_reference: CHV:0000031778
database_cross_reference: CSP:2935-5475
database_cross_reference: MSH:D019169

K562 Cells
type: Class
subclass of: Erythroid Precursor Cells
subclass of: Cell Line, Tumor
PMOID: PMO:00000645
Subclass_of: Cell Line, Tumor
Subclass_of: Erythroid Precursor Cells
Synonym: Cells, K562
Synonym: K A 562 CELLS
Tree Number: T2.13.1.3.2
Tree Number: T2.6.1.7.9
Tree Number: T2.6.4.1.9
database_cross_reference: MSH:D020014

U937 Cells
type: Class
subclass of: Monocyte-Macrophage Precursor Cells
subclass of: Cell Line, Tumor
PMOID: PMO:00000646
Subclass_of: Cell Line, Tumor
Subclass_of: Monocyte-Macrophage Precursor Cells
Synonym: Cell, U937
Synonym: Cells, U937
Synonym: U A 937 CELLS
Synonym: U937 Cell
Synonym: cells u937
Synonym: u937 cell
Synonym: u937 cells
Tree Number: T2.20.3.10.1
Tree Number: T2.20.4.2.1
Tree Number: T2.6.1.7.10
Tree Number: T2.6.4.1.10
database_cross_reference: CHV:0000042295
database_cross_reference: MSH:D020298

HCT116 Cells
type: Class
subclass of: Cell Line, Tumor
PMOID: PMO:00000647
Subclass_of: Cell Line, Tumor
Synonym: Cell, HCT 116
Synonym: Cell, HCT-116
Synonym: Cell, HCT116
Synonym: Cells, HCT 116
Synonym: Cells, HCT-116
Synonym: Cells, HCT116
Synonym: HCT 116 Cell
Synonym: HCT 116 Cells
Synonym: HCT-116 Cell
Synonym: HCT-116 Cells
Tree Number: T2.6.1.7.11
Tree Number: T2.6.4.1.11
database_cross_reference: MSH:D045325

MCF-7 Cells
type: Class
subclass of: Cell Line, Tumor
PMOID: PMO:00000648
Subclass_of: Cell Line, Tumor
Synonym: Cell, MCF-7
Synonym: Cell, MCF7
Synonym: Cells, MCF-7
Synonym: Cells, MCF7
Synonym: MCF 7 Cells
Synonym: MCF-7 Cell
Synonym: MCF7
Synonym: MCF7 Cell
Synonym: MCF7 Cells
Synonym: MCF7 cell
Tree Number: T2.6.1.7.12
database_cross_reference: CSP:4001-0077
database_cross_reference: MSH:D061986
database_cross_reference: NCI:C18096

Madin Darby Canine Kidney Cells
type: Class
subclass of: Cell Line
subclass of: Epithelial Cells
PMOID: PMO:00000649
Subclass_of: Cell Line
Subclass_of: Epithelial Cells
Synonym: Cell, MDCK
Synonym: Cells, MDCK
Synonym: MDCK Cell
Synonym: MDCK Cells
Synonym: MDCK cell
Synonym: Madin Darby canine kidney cell
Tree Number: T2.12.38
Tree Number: T2.6.1.8
database_cross_reference: CSP:4001-0078
database_cross_reference: MSH:D061985

Sf9 Cells
type: Class
subclass of: Cell Line
PMOID: PMO:00000650
Subclass_of: Cell Line
Tree Number: T2.6.1.9

Clone Cells
type: Class
subclass of: Cells, Cultured
PMOID: PMO:00000651
Subclass_of: Cells, Cultured
Synonym: Cell Clone
Synonym: Cell, Clone
Synonym: Cells, Clone
Synonym: Clone
Synonym: Clone (cell)
Synonym: Clone Cell
Synonym: Clone cells
Synonym: Clone, NOS
Synonym: Clones
Synonym: Cloning
Tree Number: T2.6.2
database_cross_reference: CHV:0000003056
database_cross_reference: CSP:2935-5444
database_cross_reference: CSP:2935-5475
database_cross_reference: CSP:4000-0369
database_cross_reference: LCH:U001055
database_cross_reference: LCH_NW:sh85027120
database_cross_reference: LCH_NW:sh85027122
database_cross_reference: MSH:D002999
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16441
database_cross_reference: SNM:F-40900
database_cross_reference: SNMI:F-C6300
database_cross_reference: SNOMEDCT_US:47308002

Hybridomas
type: Class
subclass of: Clone Cells
subclass of: Hybrid Cells
PMOID: PMO:00000652
Subclass_of: Clone Cells
Subclass_of: Hybrid Cells
Synonym: Hybridoma
Synonym: Hybridoma (cell)
Synonym: cell hybridoma
Synonym: hybridoma
Synonym: hybridomas
Tree Number: T2.6.2.1
Tree Number: T2.6.3.1
database_cross_reference: CHV:0000006326
database_cross_reference: CSP:0602-4228
database_cross_reference: LCH:U002263
database_cross_reference: LCH_NW:sh85063278
database_cross_reference: MSH:D006825
database_cross_reference: NCI:C16700
database_cross_reference: SNMI:F-C6410
database_cross_reference: SNOMEDCT_US:25326005

Hybrid Cells
type: Class
subclass of: Cells, Cultured
PMOID: PMO:00000653
Subclass_of: Cells, Cultured
Synonym: Cell Hybrid, Somatic
Synonym: Cell Hybrids, Somatic
Synonym: Cell, Hybrid
Synonym: Cells, Hybrid
Synonym: Hybrid Cell
Synonym: Hybrid, Somatic Cell
Synonym: Hybrids, Somatic Cell
Synonym: Somatic Cell Hybrid
Synonym: Somatic Cell Hybrids
Tree Number: T2.6.3
database_cross_reference: MSH:D006822
database_cross_reference: MTH:NOCODE

Tumor Cells, Cultured
type: Class
subclass of: Cells, Cultured
PMOID: PMO:00000654
Subclass_of: Cells, Cultured
Synonym: CULTURED NEOPL CELLS
Synonym: Cell, Cultured Neoplastic
Synonym: Cell, Cultured Tumor
Synonym: Cells, Cultured Neoplastic
Synonym: Cells, Cultured Tumor
Synonym: Cultured Neoplastic Cell
Synonym: Cultured Neoplastic Cells
Synonym: Cultured Tumor Cell
Synonym: Cultured Tumor Cells
Synonym: NEOPL CELLS CULTURED
Tree Number: T2.6.4
database_cross_reference: MSH:D014407

Hep G2 Cells
type: Class
subclass of: Cell Line, Tumor
subclass of: Hepatocytes
PMOID: PMO:00000655
Subclass_of: Cell Line, Tumor
Subclass_of: Hepatocytes
Synonym: Cell Line, Hep G2
Synonym: Cell Line, Hepatoblastoma G2
Synonym: Cell, Hep G2
Synonym: Cell, HepG2
Synonym: Cells, Hep G2
Synonym: Cells, HepG2
Synonym: Hep G2 Cell
Synonym: Hep G2 Cell Line
Synonym: HepG2 Cell
Synonym: HepG2 Cells
Tree Number: T2.12.26.1
Tree Number: T2.6.4.1.12
database_cross_reference: MSH:D056945

Embryonal Carcinoma Stem Cells
type: Class
subclass of: Tumor Cells, Cultured
subclass of: Neoplastic Stem Cells
subclass of: Embryonic Stem Cells
PMOID: PMO:00000656
Subclass_of: Embryonic Stem Cells
Subclass_of: Neoplastic Stem Cells
Subclass_of: Tumor Cells, Cultured
Synonym: Carcinoma Cell, Embryonal
Synonym: Carcinoma Cells, Embryonal
Synonym: Cell, Embryonal Carcinoma
Synonym: Cell, Teratocarcinoma Stem
Synonym: Cells, Embryonal Carcinoma
Synonym: Cells, Teratocarcinoma Stem
Synonym: Embryonal Carcinoma Cell
Synonym: Embryonal Carcinoma Cells
Synonym: Stem Cell, Teratocarcinoma
Synonym: Stem Cells, Teratocarcinoma
Tree Number: T2.34.3.1
Tree Number: T2.34.7.1.5
Tree Number: T2.6.4.2
database_cross_reference: MSH:D054278

Spheroids, Cellular
type: Class
subclass of: Cells, Cultured
PMOID: PMO:00000657
Subclass_of: Cells, Cultured
Synonym: Cellular Spheroid
Synonym: Cellular Spheroids
Synonym: Multicellular Spheroid
Synonym: Multicellular Spheroids
Synonym: Spheroid, Cellular
Synonym: Spheroid, Multicellular
Synonym: Spheroids, Multicellular
Tree Number: T2.6.5
database_cross_reference: MSH:D018874

Feeder Cells
type: Class
subclass of: Cells, Cultured
PMOID: PMO:00000658
Subclass_of: Cells, Cultured
Synonym: Cell, Feeder
Synonym: Cells, Feeder
Tree Number: T2.6.7
database_cross_reference: MSH:D061252

Cells, Immobilized
type: Class
subclass of: Cell
PMOID: PMO:00000659
Subclass_of: Cell
Synonym: Cell, Immobilized
Synonym: Immobilized Cell
Synonym: Immobilized Cells
Synonym: Immobilized cells
Tree Number: T2.7
database_cross_reference: LCH_NW:sh85064524
database_cross_reference: MSH:D018914

Cellular Structures
type: Class
subclass of: Cell
PMOID: PMO:00000660
Subclass_of: Cell
Synonym: Cell
Synonym: Cell Type
Synonym: Cell Types
Synonym: Cell structure
Synonym: Cell structure (body structure)
Synonym: Cell structure (cell structure)
Synonym: Cell, NOS
Synonym: Cells
Synonym: Cells (Biology)
Synonym: Cells set
Tree Number: T2.8
database_cross_reference: CHV:0000002603
database_cross_reference: CSP:0605-5409
database_cross_reference: FMA:68646
database_cross_reference: FMA:71954
database_cross_reference: GO:GO:0005623
database_cross_reference: LCH:U000874
database_cross_reference: LCH_NW:sh85021678
database_cross_reference: LNC:LP14738-6
database_cross_reference: LNC:LP174115-8
database_cross_reference: LNC:MTHU001933
database_cross_reference: MSH:D002477
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12508
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000046476
database_cross_reference: NCI_UCUM:C12508
database_cross_reference: PSY:08080
database_cross_reference: SNM:T-YX000
database_cross_reference: SNM:U000525
database_cross_reference: SNMI:T-E0000
database_cross_reference: SNOMEDCT_US:4421005
database_cross_reference: UWDA:68646
database_cross_reference: UWDA:71954

Chromaffin Cells
type: Class
subclass of: Cell
PMOID: PMO:00000661
Subclass_of: Cell
Synonym: Cell, Chromaffin
Synonym: Cells, Chromaffin
Synonym: Chromaffin Cell
Synonym: Chromaffin cell
Synonym: Chromaffin cells
Synonym: Phaeochromocyte
Synonym: Pheochromocyte
Synonym: chromaffin cell
Synonym: chromaffin cells
Tree Number: T2.9
database_cross_reference: CHV:0000031833
database_cross_reference: CSP:0605-5566
database_cross_reference: FMA:69263
database_cross_reference: LCH:U006354
database_cross_reference: LCH_NW:sh85025330
database_cross_reference: MSH:D019439
database_cross_reference: NCI:C12554
database_cross_reference: NCI_NCI-GLOSS:CDR0000537551
database_cross_reference: UWDA:69263

Connective Tissue Cells
type: Class
subclass of: Cell
PMOID: PMO:00000662
Subclass_of: Cell
Synonym: Cell of connective tissue
Synonym: Cell, Connective Tissue
Synonym: Cells, Connective Tissue
Synonym: Connective Tissue Cell
Synonym: Connective and Soft Tissue Cell
Synonym: Connective tissue cell
Synonym: Connective tissue cells
Synonym: cells connective tissue
Synonym: connective tissue cell
Synonym: connective tissue cells
Tree Number: T2.10
database_cross_reference: AOD:0000016852
database_cross_reference: CHV:0000003294
database_cross_reference: CSP:0729-6098
database_cross_reference: FMA:63875
database_cross_reference: LCH_NW:sh85031182
database_cross_reference: MSH:D003239
database_cross_reference: NCI:C12555
database_cross_reference: PSY:11320
database_cross_reference: UWDA:63875

Tenocytes
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000663
Subclass_of: Connective Tissue Cells
Synonym: Tenocyte
Tree Number: T2.10.1
database_cross_reference: MSH:D000070916

Synoviocytes
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000664
Subclass_of: Connective Tissue Cells
Synonym: Hyaluronic acid secreting cell
Synonym: Synovial Cell
Synonym: Synovial Cells
Synonym: Synovial cell
Synonym: Synovial cells
Synonym: Synoviocyte
Synonym: Synoviocytes (cell)
Synonym: synovial cell
Synonym: synoviocyte
Synonym: synoviocytes
Tree Number: T2.10.2
database_cross_reference: CHV:0000021806
database_cross_reference: FMA:66786
database_cross_reference: LNC:LP18365-4
database_cross_reference: LNC:MTHU004088
database_cross_reference: MSH:D000070918
database_cross_reference: NCI:C13059
database_cross_reference: SNM:T-1Y100
database_cross_reference: SNMI:T-15096
database_cross_reference: SNOMEDCT_US:76323008
database_cross_reference: UWDA:66786

Fibroblasts
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000665
Subclass_of: Connective Tissue Cells
Synonym: Fibroblast
Synonym: Fibroblast (cell)
Synonym: Fibroblasts [Chemical/Ingredient]
Synonym: cells fibroblast
Synonym: fibroblast
Synonym: fibroblast cell
Synonym: fibroblasts
Tree Number: T2.10.3
database_cross_reference: AOD:0000016706
database_cross_reference: CHV:0000005024
database_cross_reference: CSP:0729-6107
database_cross_reference: FMA:63877
database_cross_reference: LCH:U001783
database_cross_reference: LCH_NW:sh85048034
database_cross_reference: LNC:LP7234-0
database_cross_reference: LNC:MTHU010959
database_cross_reference: MSH:D005347
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12482
database_cross_reference: NCI_NCI-GLOSS:CDR0000044590
database_cross_reference: NDFRT:N0000184311
database_cross_reference: SNM:T-1X101
database_cross_reference: SNMI:T-1A101
database_cross_reference: SNOMEDCT_US:52547004
database_cross_reference: UWDA:63877

Cancer-Associated Fibroblasts
type: Class
subclass of: Fibroblasts
PMOID: PMO:00000666
Subclass_of: Fibroblasts
Synonym: Cancer Associated Fibroblast
Synonym: Cancer Associated Fibroblasts
Synonym: Cancer-Associated Fibroblast
Synonym: Fibroblast, Cancer Associated
Synonym: Fibroblast, Cancer-Associated
Synonym: Fibroblast, Tumor-Associated
Synonym: Fibroblasts, Cancer Associated
Synonym: Fibroblasts, Cancer-Associated
Synonym: Fibroblasts, Tumor-Associated
Synonym: Tumor Associated Fibroblasts
Tree Number: T2.10.3.1
database_cross_reference: MSH:D000072645

Mesangial Cells
type: Class
subclass of: Fibroblasts
PMOID: PMO:00000667
Subclass_of: Fibroblasts
Synonym: Cell, Kidney Mesangial
Synonym: Cell, Mesangial
Synonym: Cell, Renal Mesangial
Synonym: Cells, Kidney Mesangial
Synonym: Cells, Mesangial
Synonym: Cells, Renal Mesangial
Synonym: Glomerular mesangial cell
Synonym: Kidney Mesangial Cell
Synonym: Kidney Mesangial Cells
Synonym: Mesangial Cell
Tree Number: T2.10.3.5
database_cross_reference: CHV:0000022154
database_cross_reference: CSP:1681-3921
database_cross_reference: FMA:70972
database_cross_reference: MSH:D050527
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C13159
database_cross_reference: SNM:T-71292
database_cross_reference: SNMI:T-71292
database_cross_reference: SNOMEDCT_US:24259000
database_cross_reference: UWDA:70972

Myofibroblasts
type: Class
subclass of: Fibroblasts
subclass of: Myocytes, Smooth Muscle
PMOID: PMO:00000668
Subclass_of: Fibroblasts
Subclass_of: Myocytes, Smooth Muscle
Synonym: Myofibroblast
Synonym: Myofibroblast (cell)
Synonym: myofibroblast
Synonym: myofibroblasts
Tree Number: T2.10.3.6
Tree Number: T2.19.3.1
database_cross_reference: CHV:0000021900
database_cross_reference: LCH_NW:sh99001909
database_cross_reference: MSH:D058628
database_cross_reference: NCI:C33153
database_cross_reference: SNM:T-1X350
database_cross_reference: SNMI:T-1A550
database_cross_reference: SNOMEDCT_US:56790003

Corneal Keratocytes
type: Class
subclass of: Fibroblasts
PMOID: PMO:00000669
Subclass_of: Fibroblasts
Synonym: Corneal Keratocyte
Synonym: Keratocyte, Corneal
Synonym: Keratocytes, Corneal
Tree Number: T2.10.3.7
database_cross_reference: MSH:D060527

Macrophages
type: Class
subclass of: Connective Tissue Cells
subclass of: Myeloid Cells
subclass of: Phagocytes
PMOID: PMO:00000670
Subclass_of: Connective Tissue Cells
Subclass_of: Myeloid Cells
Subclass_of: Phagocytes
Synonym: Bone Marrow Derived Macrophages
Synonym: Bone Marrow-Derived Macrophage
Synonym: Bone Marrow-Derived Macrophages
Synonym: Clasmatocyte
Synonym: Macrophage
Synonym: Macrophage (cell)
Synonym: Macrophage, Bone Marrow-Derived
Synonym: Macrophage, Monocyte-Derived
Synonym: Macrophages, Bone Marrow-Derived
Synonym: Macrophages, Monocyte Derived
Tree Number: T2.10.4
Tree Number: T2.20.3
Tree Number: T2.27.1
database_cross_reference: AOD:0000017509
database_cross_reference: CHV:0000007648
database_cross_reference: CSP:0432-6461
database_cross_reference: FMA:63261
database_cross_reference: LCH:U002774
database_cross_reference: LCH_NW:sh85079451
database_cross_reference: LNC:LP14314-6
database_cross_reference: LNC:MTHU016340
database_cross_reference: MSH:D008264
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12558
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044054
database_cross_reference: SNM:T-05128
database_cross_reference: SNMI:T-C0128
database_cross_reference: SNOMEDCT_US:58986001

Foam Cells
type: Class
subclass of: Macrophages
PMOID: PMO:00000671
Subclass_of: Macrophages
Synonym: Cell, Foam
Synonym: Cells, Foam
Synonym: Foam Cell
Synonym: Foam cell
Synonym: Foam cell (body structure)
Synonym: Foam cell (cell)
Synonym: Foam cells
Synonym: Foamy Macrophage
Synonym: Foamy histiocytes
Synonym: Foamy macrophages
Tree Number: T2.10.4.1
Tree Number: T2.20.3.1
Tree Number: T2.27.1.2
database_cross_reference: CHV:0000005142
database_cross_reference: CSP:0432-6461
database_cross_reference: FMA:83586
database_cross_reference: HPO:HP:0003651
database_cross_reference: MSH:D005487
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12560
database_cross_reference: OMIM:MTHU054378
database_cross_reference: SNM:M-69520
database_cross_reference: SNMI:M-62030
database_cross_reference: SNOMEDCT_US:16980002

Histiocytes
type: Class
subclass of: Macrophages
PMOID: PMO:00000672
Subclass_of: Macrophages
Synonym: Connective tissue macrophage
Synonym: Fixed Macrophage
Synonym: Fixed macrophage
Synonym: Histiocyte
Synonym: Histiocyte, NOS
Synonym: Histocyte
Synonym: Histocyte, NOS
Synonym: Resident tissue macrophage
Synonym: Resident tissue macrophage (cell)
Synonym: Tissue macrophage
Tree Number: T2.10.4.2
Tree Number: T2.20.3.2
Tree Number: T2.27.1.3
database_cross_reference: AOD:0000017512
database_cross_reference: CHV:0000006163
database_cross_reference: CSP:0432-6461
database_cross_reference: FMA:83585
database_cross_reference: FMA:84642
database_cross_reference: LNC:LA12897-7
database_cross_reference: LNC:LP18378-7
database_cross_reference: LNC:MTHU004278
database_cross_reference: MSH:D006644
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12563
database_cross_reference: SNM:T-05120
database_cross_reference: SNMI:T-C0120
database_cross_reference: SNOMEDCT_US:14295007

Kupffer Cells
type: Class
subclass of: Macrophages
PMOID: PMO:00000673
Subclass_of: Macrophages
Synonym: Cells, Kupffer
Synonym: Hepatic macrophage
Synonym: Hepatic sinusoidal macrophage
Synonym: Hepatic stellate cell
Synonym: Kupffer Cell
Synonym: Kupffer cell
Synonym: Kupffer cell (body structure)
Synonym: Kupffer cell (cell)
Synonym: Kupffer cells
Synonym: Kupffer's Cell
Tree Number: T2.10.4.3
Tree Number: T2.20.3.3
Tree Number: T2.27.1.4
database_cross_reference: AOD:0000017322
database_cross_reference: CHV:0000007138
database_cross_reference: CSP:1754-0982
database_cross_reference: FMA:14656
database_cross_reference: LCH:U002593
database_cross_reference: LCH_NW:sh85073457
database_cross_reference: MSH:D007728
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12564
database_cross_reference: SNM:T-56250
database_cross_reference: SNMI:T-62250
database_cross_reference: SNOMEDCT_US:256002
database_cross_reference: SNOMEDCT_VET:256002

Osteoclasts
type: Class
subclass of: Macrophages
PMOID: PMO:00000674
Subclass_of: Macrophages
Synonym: Osteoclast
Synonym: Osteoclast (cell)
Synonym: osteoclast
Synonym: osteoclasts
Tree Number: T2.10.4.4
Tree Number: T2.20.3.4
database_cross_reference: AOD:0000016872
database_cross_reference: CHV:0000009079
database_cross_reference: CSP:2715-3929
database_cross_reference: FMA:66781
database_cross_reference: LCH_NW:sh90003255
database_cross_reference: MSH:D010010
database_cross_reference: NCI:C12570
database_cross_reference: SNM:T-1X586
database_cross_reference: SNMI:T-11064
database_cross_reference: SNOMEDCT_US:27770000
database_cross_reference: UWDA:66781

Epithelioid Cells
type: Class
subclass of: Macrophages
PMOID: PMO:00000675
Subclass_of: Macrophages
Synonym: Cell, Epithelioid
Synonym: Cells, Epithelioid
Synonym: Epithelioid Cell
Synonym: Epithelioid cell
Synonym: epithelioid cell
Synonym: epithelioid cells
Tree Number: T2.10.4.5
Tree Number: T2.20.3.5
Tree Number: T2.27.1.5
database_cross_reference: CHV:0000004579
database_cross_reference: FMA:83514
database_cross_reference: MSH:D015622
database_cross_reference: NCI:C12559

Giant Cells, Foreign-Body
type: Class
subclass of: Macrophages
subclass of: Giant Cells
PMOID: PMO:00000676
Subclass_of: Giant Cells
Subclass_of: Macrophages
Synonym: Cell, Foreign-Body Giant
Synonym: Cells, Foreign-Body Giant
Synonym: Foreign Body Giant Cell
Synonym: Foreign Body Giant Cells
Synonym: Foreign Body Type Giant Cells
Synonym: Foreign Body-Type Giant Cells
Synonym: Foreign body giant cell
Synonym: Foreign body giant cell (body structure)
Synonym: Foreign body giant cell (cell)
Synonym: Foreign body giant cell, NOS
Tree Number: T2.10.4.6
Tree Number: T2.16.1
Tree Number: T2.20.3.6
Tree Number: T2.27.1.6
database_cross_reference: CHV:0000005485
database_cross_reference: MSH:D015743
database_cross_reference: NCI:C12561
database_cross_reference: SNMI:M-62510
database_cross_reference: SNOMEDCT_US:21386001

Giant Cells, Langhans
type: Class
subclass of: Macrophages
subclass of: Giant Cells
PMOID: PMO:00000677
Subclass_of: Giant Cells
Subclass_of: Macrophages
Synonym: Cells, Langhans Giant
Synonym: Cells, Langhans-Type Giant
Synonym: Giant Cells, Langhans-Type
Synonym: Langhans Cell
Synonym: Langhans Giant Cells
Synonym: Langhans Type Giant Cells
Synonym: Langhans giant cell
Synonym: Langhans giant cell (body structure)
Synonym: Langhans giant cell (cell)
Synonym: Langhans' - Type Giant Cell
Tree Number: T2.10.4.7
Tree Number: T2.16.2
Tree Number: T2.20.3.7
Tree Number: T2.27.1.7
database_cross_reference: MSH:D015744
database_cross_reference: NCI:C12562
database_cross_reference: SNMI:M-62530
database_cross_reference: SNOMEDCT_US:30938003

Macrophages, Alveolar
type: Class
subclass of: Macrophages
PMOID: PMO:00000678
Subclass_of: Macrophages
Synonym: Alveolar Macrophage
Synonym: Alveolar Macrophages
Synonym: Alveolar macrophage
Synonym: Alveolar macrophage (cell)
Synonym: MACROPHAGE PULM
Synonym: MACROPHAGES PULM
Synonym: Macrophage, Alveolar
Synonym: Macrophage, Pulmonary
Synonym: Macrophages, Pulmonary
Synonym: PULM MACROPHAGE
Tree Number: T2.10.4.8
Tree Number: T2.20.3.8
Tree Number: T2.27.1.8
database_cross_reference: CHV:0000015511
database_cross_reference: CSP:2612-1304
database_cross_reference: FMA:83023
database_cross_reference: MSH:D016676
database_cross_reference: NCI:C12565
database_cross_reference: SNMI:T-28053
database_cross_reference: SNOMEDCT_US:33956004

Macrophages, Peritoneal
type: Class
subclass of: Macrophages
PMOID: PMO:00000679
Subclass_of: Macrophages
Synonym: Macrophage, Peritoneal
Synonym: Peritoneal Macrophage
Synonym: Peritoneal Macrophages
Synonym: Peritoneal macrophage
Synonym: peritoneal macrophage
Synonym: peritoneal macrophages
Tree Number: T2.10.4.9
Tree Number: T2.20.3.9
Tree Number: T2.27.1.9
database_cross_reference: CHV:0000020854
database_cross_reference: FMA:83025
database_cross_reference: MSH:D017737
database_cross_reference: NCI:C12566

Mast Cells
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000680
Subclass_of: Connective Tissue Cells
Synonym: Basophil, Tissue
Synonym: Basophilic histiocyte
Synonym: Basophils, Tissue
Synonym: Cell, Mast
Synonym: Cells, Mast
Synonym: Histaminocyte
Synonym: Marrow mast cell
Synonym: Mast Cell
Synonym: Mast cell
Synonym: Mast cell (body structure)
Tree Number: T2.10.5
database_cross_reference: CHV:0000007777
database_cross_reference: CSP:0605-5591
database_cross_reference: FMA:66784
database_cross_reference: LCH:U002830
database_cross_reference: LCH_NW:sh85081982
database_cross_reference: LNC:LP15073-7
database_cross_reference: MSH:D008407
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12747
database_cross_reference: NCI_NCI-GLOSS:CDR0000044845
database_cross_reference: SNM:T-05140
database_cross_reference: SNM:T-06570
database_cross_reference: SNMI:T-C0140
database_cross_reference: SNOMEDCT_US:6445007
database_cross_reference: UWDA:66784

Odontoblasts
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000681
Subclass_of: Connective Tissue Cells
Synonym: Odontoblast
Synonym: odontoblast
Synonym: odontoblasts
Tree Number: T2.10.6
database_cross_reference: CHV:0000008905
database_cross_reference: CSP:0837-0437
database_cross_reference: FMA:62999
database_cross_reference: MSH:D009804
database_cross_reference: NCI:C12567
database_cross_reference: UWDA:62999

Osteoblasts
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000682
Subclass_of: Connective Tissue Cells
Synonym: Osteoblast
Synonym: Osteoblast (cell)
Synonym: cells osteoblast
Synonym: cells osteoblasts
Synonym: osteoblast
Synonym: osteoblasts
Tree Number: T2.10.7
database_cross_reference: AOD:0000016871
database_cross_reference: CHV:0000009072
database_cross_reference: CSP:2715-3886
database_cross_reference: FMA:66780
database_cross_reference: LCH_NW:sh2012001687
database_cross_reference: LNC:LP96511-8
database_cross_reference: MSH:D010006
database_cross_reference: NCI:C12568
database_cross_reference: SNM:T-1X582
database_cross_reference: SNMI:T-11062
database_cross_reference: SNOMEDCT_US:48156001
database_cross_reference: UWDA:66780

Osteocytes
type: Class
subclass of: Osteoblasts
PMOID: PMO:00000683
Subclass_of: Osteoblasts
Synonym: Bone cell
Synonym: Osteocyte
Synonym: Osteocyte (cell)
Synonym: osteocyte
Synonym: osteocytes
Tree Number: T2.10.7.1
database_cross_reference: CHV:0000009080
database_cross_reference: CSP:2715-3843
database_cross_reference: FMA:66779
database_cross_reference: LCH_NW:sh91003881
database_cross_reference: MSH:D010011
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12569
database_cross_reference: SNM:T-1X583
database_cross_reference: SNMI:T-11063
database_cross_reference: SNOMEDCT_US:23821005
database_cross_reference: UWDA:66779

Theca Cells
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000684
Subclass_of: Connective Tissue Cells
Synonym: Cell, Ovarian Interstitial
Synonym: Cell, Theca
Synonym: Cells, Ovarian Interstitial
Synonym: Cells, Theca
Synonym: Endocrinocytus interstitialis (Ovarium)
Synonym: Interstitial Cell, Ovarian
Synonym: Interstitial Cells, Ovarian
Synonym: Interstitial cell of ovary
Synonym: Ovarian Interstitial Cell
Synonym: Ovarian Interstitial Cells
Tree Number: T2.10.8
database_cross_reference: CHV:0000012153
database_cross_reference: CSP:2587-4290
database_cross_reference: FMA:18709
database_cross_reference: MSH:D013799
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12572
database_cross_reference: UWDA:18709

Stromal Cells
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000685
Subclass_of: Connective Tissue Cells
Synonym: Cell, Stromal
Synonym: Cells, Stromal
Synonym: Stromal Cell
Synonym: Stromal cell
Synonym: stromal cell
Synonym: stromal cells
Tree Number: T2.10.9
database_cross_reference: CHV:0000017910
database_cross_reference: CSP:0594-0219
database_cross_reference: FMA:83624
database_cross_reference: MSH:D017154
database_cross_reference: NCI:C12571
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000559134

Telocytes
type: Class
subclass of: Stromal Cells
PMOID: PMO:00000686
Subclass_of: Stromal Cells
Synonym: Cajal-Like Cells, Interstitial
Synonym: Cells, Interstitial Cajal-Like
Synonym: Interstitial Cajal Like Cells
Synonym: Interstitial Cajal-Like Cells
Synonym: Interstitial Cell of Cajal Like Cells
Synonym: Interstitial Cell of Cajal-Like Cells
Synonym: Telocyte
Tree Number: T2.10.9.1
database_cross_reference: MSH:D000067170

Mesenchymal Stromal Cells
type: Class
subclass of: Stromal Cells
subclass of: Multipotent Stem Cells
PMOID: PMO:00000687
Subclass_of: Multipotent Stem Cells
Subclass_of: Stromal Cells
Synonym: Cell, Mesenchymal Stromal
Synonym: Cells, Mesenchymal Stromal
Synonym: Mesenchymal Stromal Cell
Synonym: Stromal Cell, Mesenchymal
Synonym: Stromal Cells, Mesenchymal
Tree Number: T2.10.9.2
Tree Number: T2.34.6.1
database_cross_reference: MSH:D059630

Adipocytes
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000688
Subclass_of: Connective Tissue Cells
Synonym: Adipocyte
Synonym: Adipocyte (cell)
Synonym: Adipose Cell
Synonym: Adipose cell
Synonym: Cell, Fat
Synonym: Cells, Fat
Synonym: Fat Cell
Synonym: Fat Cells
Synonym: Fat cell
Synonym: Fat cells
Tree Number: T2.10.10
database_cross_reference: AOD:0000016855
database_cross_reference: AOD:0000027612
database_cross_reference: AOD:0000027613
database_cross_reference: CHV:0000020815
database_cross_reference: CSP:0729-5644
database_cross_reference: FMA:63880
database_cross_reference: LCH_NW:sh86006585
database_cross_reference: MSH:D017667
database_cross_reference: NCI:C12556
database_cross_reference: NCI:C32991
database_cross_reference: SNM:T-1X013
database_cross_reference: SNMI:T-1A013
database_cross_reference: SNOMEDCT_US:24826007
database_cross_reference: UWDA:63880

Adipocytes, Beige
type: Class
subclass of: Adipocytes
PMOID: PMO:00000689
Subclass_of: Adipocytes
Synonym: Adipocyte, Beige
Synonym: Adipocyte, Beige Brite
Synonym: Adipocyte, Brite
Synonym: Adipocytes, Beige Brite
Synonym: Adipocytes, Brite
Synonym: Beige Adipocyte
Synonym: Beige Adipocytes
Synonym: Beige Brite Adipocyte
Synonym: Beige Brite Adipocytes
Synonym: Beige Brite Cell
Tree Number: T2.10.10.1
database_cross_reference: MSH:D000069797

Adipocytes, Brown
type: Class
subclass of: Adipocytes
PMOID: PMO:00000690
Subclass_of: Adipocytes
Synonym: Adipocyte, Brown
Synonym: Brown Adipocyte
Synonym: Brown Adipocytes
Synonym: Brown Fat Cell
Synonym: Brown Fat Cells
Synonym: Brown adipocyte
Synonym: Brown adipose cell
Synonym: Brown fat cell
Synonym: Cell, Brown Fat
Synonym: Cells, Brown Fat
Tree Number: T2.10.10.2
database_cross_reference: FMA:83435
database_cross_reference: MSH:D052437

Adipocytes, White
type: Class
subclass of: Adipocytes
PMOID: PMO:00000691
Subclass_of: Adipocytes
Synonym: Adipocyte, White
Synonym: Cell, White Fat
Synonym: Cells, White Fat
Synonym: Fat Cell, White
Synonym: Fat Cells, White
Synonym: White Adipocyte
Synonym: White Adipocytes
Synonym: White Fat Cell
Synonym: White Fat Cells
Synonym: White adipocyte
Tree Number: T2.10.10.3
database_cross_reference: FMA:83434
database_cross_reference: MSH:D052438

Chondrocytes
type: Class
subclass of: Connective Tissue Cells
PMOID: PMO:00000692
Subclass_of: Connective Tissue Cells
Synonym: Cartilage cell
Synonym: Cartilage cell, NOS
Synonym: Chondrocyte
Synonym: Chondrocyte (cell)
Synonym: Chondrocyte (substance)
Synonym: Chondrocyte cell
Synonym: Chondrocyte cell (substance)
Synonym: Chondrocytes [Chemical/Ingredient]
Synonym: cartilage cell
Synonym: chondrocyte
Tree Number: T2.10.11
database_cross_reference: AOD:0000016869
database_cross_reference: AOD:0000027617
database_cross_reference: CHV:0000021903
database_cross_reference: CSP:2715-4316
database_cross_reference: FMA:66782
database_cross_reference: MSH:D019902
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12557
database_cross_reference: NCI_NCI-GLOSS:CDR0000044191
database_cross_reference: NDFRT:N0000184995
database_cross_reference: SNM:T-1X741
database_cross_reference: SNM:T-1X743
database_cross_reference: SNMI:T-1A741
database_cross_reference: SNMI:T-1A743
database_cross_reference: SNOMEDCT_US:429351002
database_cross_reference: SNOMEDCT_US:433180002
database_cross_reference: SNOMEDCT_US:81272008
database_cross_reference: UWDA:66782

Endocrine Cells
type: Class
subclass of: Cell
PMOID: PMO:00000693
Subclass_of: Cell
Synonym: Cell, Endocrine
Synonym: Cells, Endocrine
Synonym: Endocrine Cell
Synonym: Endocrine cell
Synonym: Endocrine cell (body structure)
Synonym: Endocrine cell (cell)
Synonym: Endocrine cell, NOS
Synonym: cells endocrine
Synonym: endocrine cell
Tree Number: T2.11
database_cross_reference: CHV:0000022358
database_cross_reference: FMA:83809
database_cross_reference: MSH:D055098
database_cross_reference: NCI:C32506
database_cross_reference: SNM:T-90160
database_cross_reference: SNMI:T-B0160
database_cross_reference: SNOMEDCT_US:68233007

APUD Cells
type: Class
subclass of: Endocrine Cells
PMOID: PMO:00000694
Subclass_of: Endocrine Cells
Synonym: APUD Cell
Synonym: APUD cell
Synonym: APUD cell group
Synonym: Amine Precursor Uptake and Decarboxylation Cells
Synonym: Amine precursor uptake and decarboxylation cell
Synonym: Amine precursor uptake and decarboxylation cell group
Synonym: Cell, APUD
Synonym: Cells, APUD
Synonym: Set of APUD cells
Synonym: apud cell
Tree Number: T2.11.1
database_cross_reference: CHV:0000001403
database_cross_reference: FMA:68651
database_cross_reference: FMA:83114
database_cross_reference: MSH:D001078
database_cross_reference: NCI:C12655
database_cross_reference: UWDA:68651

Granulosa Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000695
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cell, Granulosa
Synonym: Cells, Granulosa
Synonym: Granulosa Cell
Synonym: Granulosa cell
Synonym: Granulosa cell of ovary
Synonym: Ovarian Granulosa Cell
Synonym: cells granulosa
Synonym: granulosa cell
Synonym: granulosa cells
Tree Number: T2.11.2
Tree Number: T2.12.6
database_cross_reference: CHV:0000005694
database_cross_reference: CSP:2587-4310
database_cross_reference: FMA:18718
database_cross_reference: MSH:D006107
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12587
database_cross_reference: NCI:C41607
database_cross_reference: UWDA:18718

Cumulus Cells
type: Class
subclass of: Granulosa Cells
PMOID: PMO:00000696
Subclass_of: Granulosa Cells
Synonym: Cell, Cumulus
Synonym: Cell, Cumulus Granulosa
Synonym: Cells, Cumulus
Synonym: Cells, Cumulus Granulosa
Synonym: Cumulus Cell
Synonym: Cumulus Granulosa Cell
Synonym: Cumulus Granulosa Cells
Synonym: Granulosa Cell, Cumulus
Synonym: Granulosa Cells, Cumulus
Tree Number: T2.11.2.1
Tree Number: T2.12.6.1
database_cross_reference: MSH:D054885

Leydig Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000697
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cell, Testicular Interstitial
Synonym: Cells, Leydig
Synonym: Cells, Testicular Interstitial
Synonym: Interstitial Cell of Testis
Synonym: Interstitial Cell of the Testis
Synonym: Interstitial Cell, Testicular
Synonym: Interstitial Cells, Testicular
Synonym: Interstitial cell of Leydig
Synonym: Leydig Cell
Synonym: Leydig cell
Tree Number: T2.11.3
Tree Number: T2.12.9
database_cross_reference: AOD:0000017428
database_cross_reference: AOD:0000027854
database_cross_reference: AOD:0000027856
database_cross_reference: CHV:0000007381
database_cross_reference: CSP:2587-5718
database_cross_reference: FMA:72297
database_cross_reference: LCH:U002674
database_cross_reference: LCH_NW:sh85076366
database_cross_reference: MSH:D007985
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12609
database_cross_reference: SNM:T-78210
database_cross_reference: SNMI:T-94210
database_cross_reference: SNOMEDCT_US:44185004

Luteal Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000698
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cell, Luteal
Synonym: Cell, Lutein
Synonym: Cells, Luteal
Synonym: Cells, Lutein
Synonym: Luteal Cell
Synonym: Luteal cell
Synonym: Lutein Cell
Synonym: Lutein Cells
Synonym: Lutein cell
Synonym: luteal cell
Tree Number: T2.11.4
Tree Number: T2.12.10
database_cross_reference: AOD:0000017400
database_cross_reference: FMA:18688
database_cross_reference: MSH:D008184
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12610
database_cross_reference: UWDA:18688

Sertoli Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000699
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cells, Sertoli
Synonym: Sertoli Cell
Synonym: Sertoli cell
Synonym: Sertoli cells
Synonym: Structure of sertoli cell
Synonym: Structure of sertoli cell (body structure)
Synonym: Structure of sertoli cell (cell structure)
Synonym: Sustentacular Cell of Testis
Synonym: Sustentacular cell of testis
Synonym: sertoli cell
Tree Number: T2.11.5
Tree Number: T2.12.13
database_cross_reference: CHV:0000011229
database_cross_reference: CSP:2587-5730
database_cross_reference: FMA:72298
database_cross_reference: LCH:U004273
database_cross_reference: LCH_NW:sh85120330
database_cross_reference: MSH:D012708
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12595
database_cross_reference: SNM:T-78110
database_cross_reference: SNMI:T-94110
database_cross_reference: SNOMEDCT_US:40281007
database_cross_reference: UWDA:72298

Enteroendocrine Cells
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000700
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: ENDOCRINE CELLS GUT
Synonym: Endocrine Cell, Gastrointestinal
Synonym: Endocrine Cells of Gut
Synonym: Endocrine Cells, Gastrointestinal
Synonym: Enterochromaffin cell
Synonym: Enteroendocrine Cell
Synonym: Enteroendocrine cell
Synonym: Enteroendocrine cell (body structure)
Synonym: Enteroendocrine cell (cell)
Synonym: GEP endocrine cell
Tree Number: T2.11.7
Tree Number: T2.12.21
database_cross_reference: CSP:0605-5566
database_cross_reference: FMA:62930
database_cross_reference: MSH:D019858
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45968
database_cross_reference: SNOMEDCT_US:3789000

Enterochromaffin-like Cells
type: Class
subclass of: Enteroendocrine Cells
PMOID: PMO:00000701
Subclass_of: Enteroendocrine Cells
Synonym: ECL Cell
Synonym: ECL Cells
Synonym: Enterochromaffin like Cells
Synonym: Enterochromaffin-Like Cell
Synonym: Enterochromaffin-like Cell
Synonym: Enterochromaffin-like cell
Synonym: Enterochromaffin-like cell (body structure)
Synonym: Enterochromaffin-like cell (cell)
Synonym: Gastric argentaffin cell
Synonym: Gastric argentaffin cells
Tree Number: T2.11.7.2
Tree Number: T2.12.21.2
database_cross_reference: CHV:0000038379
database_cross_reference: MSH:D019861
database_cross_reference: NCI:C12576
database_cross_reference: SNM:T-63090
database_cross_reference: SNMI:T-57090
database_cross_reference: SNOMEDCT_US:14099006

Glucagon-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
PMOID: PMO:00000702
Subclass_of: Enteroendocrine Cells
Synonym: A-cell of pancreatic islet
Synonym: Alpha Cell
Synonym: Alpha cell
Synonym: Alpha cell of pancreas
Synonym: Alpha cell of pancreatic islet
Synonym: Cell, Glucagon-Secreting
Synonym: Cells, Glucagon-Secreting
Synonym: Glucagon Cell
Synonym: Glucagon Secreting Cell
Synonym: Glucagon Secreting Cells
Tree Number: T2.11.7.5
Tree Number: T2.12.21.5
database_cross_reference: CHV:0000009215
database_cross_reference: CSP:2204-1776
database_cross_reference: FMA:70585
database_cross_reference: FMA:84045
database_cross_reference: FMA:85703
database_cross_reference: MSH:D050416
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32052
database_cross_reference: SNM:T-99100
database_cross_reference: SNMI:T-B9100
database_cross_reference: SNOMEDCT_US:61028007
database_cross_reference: UWDA:70585

Insulin-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
PMOID: PMO:00000703
Subclass_of: Enteroendocrine Cells
Synonym: B Cell, Pancreatic
Synonym: B Cells, Pancreatic
Synonym: B-cell of pancreatic islet
Synonym: Beta Cell
Synonym: Beta cell
Synonym: Beta cell of pancreatic islet
Synonym: Cell, Insulin-Secreting
Synonym: Cells, Insulin-Secreting
Synonym: Insulin Cell
Synonym: Insulin Secreting Cell
Tree Number: T2.11.7.6
Tree Number: T2.12.21.6
database_cross_reference: CHV:0000009216
database_cross_reference: CSP:2204-1776
database_cross_reference: FMA:70586
database_cross_reference: FMA:85704
database_cross_reference: LCH_NW:sh89006279
database_cross_reference: MSH:D050417
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32199
database_cross_reference: SNM:T-99200
database_cross_reference: SNMI:T-B9200
database_cross_reference: SNOMEDCT_US:36565008
database_cross_reference: UWDA:70586

Pancreatic Polypeptide-Secreting Cells
type: Class
subclass of: Enteroendocrine Cells
PMOID: PMO:00000704
Subclass_of: Enteroendocrine Cells
Synonym: Cell, Pancreatic Polypeptide-Secreting
Synonym: Cells, Pancreatic Polypeptide-Secreting
Synonym: PP Cell, Pancreatic
Synonym: PP Cells, Pancreatic
Synonym: PP-cell of pancreatic islet
Synonym: Pancreatic PP Cell
Synonym: Pancreatic PP Cells
Synonym: Pancreatic Polypeptide Cell
Synonym: Pancreatic Polypeptide Cells
Synonym: Pancreatic Polypeptide Secreting Cells
Tree Number: T2.11.7.7
Tree Number: T2.12.21.7
database_cross_reference: FMA:280118
database_cross_reference: FMA:70588
database_cross_reference: MSH:D050418
database_cross_reference: UWDA:70588

Corticotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000705
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: ACTH Cell
Synonym: ACTH-Producing Cell, Pituitary
Synonym: ACTH-Producing Cells, Pituitary
Synonym: ACTH-Secreting Cell, Pituitary
Synonym: ACTH-Secreting Cells, Pituitary
Synonym: Adrenocorticotropin-Secreting Cell, Pituitary
Synonym: Adrenocorticotropin-Secreting Cells, Pituitary
Synonym: Cells, Pituitary Adrenocorticotropin-Secreting
Synonym: Corticotrope
Synonym: Corticotrope Cell
Tree Number: T2.11.8
Tree Number: T2.12.30
database_cross_reference: FMA:83098
database_cross_reference: MSH:D052680
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32390
database_cross_reference: SNM:T-91160
database_cross_reference: SNMI:T-B1160
database_cross_reference: SNOMEDCT_US:113332000

Gonadotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000706
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Gonadotrope
Synonym: Gonadotrope Cell
Synonym: Gonadotrope cell
Synonym: Gonadotroph
Synonym: Gonadotroph Cell
Synonym: Pituitary delta cell
Synonym: Pituitary delta cell (body structure)
Synonym: Pituitary delta cell (cell)
Synonym: Pituitary gonadotropic cell
Tree Number: T2.11.9
Tree Number: T2.12.31
database_cross_reference: FMA:83100
database_cross_reference: MSH:D052681
database_cross_reference: NCI:C32691
database_cross_reference: SNMI:T-B11A0
database_cross_reference: SNOMEDCT_US:44490009

Lactotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000707
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Lactotrope Cell
Synonym: Lactotrope cell
Synonym: Lactotroph
Synonym: Lactotroph Cell
Synonym: Mammotrope
Synonym: Mammotroph
Synonym: PRL Cell
Synonym: Pituitary Prolactin Cell
Synonym: Pituitary Prolactin Cells
Synonym: Pituitary Prolactin Secreting Cells
Tree Number: T2.11.10
Tree Number: T2.12.32
database_cross_reference: CHV:0000042652
database_cross_reference: CSP:2335-0113
database_cross_reference: FMA:83096
database_cross_reference: MSH:D052682
database_cross_reference: NCI:C32911
database_cross_reference: SNM:T-91150
database_cross_reference: SNMI:T-B1150
database_cross_reference: SNOMEDCT_US:65357006

Somatotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000708
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: GH Cell
Synonym: GH Cell, Pituitary
Synonym: GH Cells, Pituitary
Synonym: Growth hormone secreting cell
Synonym: Pituitary GH Cell
Synonym: Pituitary GH Cells
Synonym: Pituitary Growth Hormone Secreting Cells
Synonym: Pituitary Growth Hormone-Secreting Cells
Synonym: Somatotrope Cell
Synonym: Somatotrope cell
Tree Number: T2.11.11
Tree Number: T2.12.33
database_cross_reference: FMA:83095
database_cross_reference: MSH:D052683
database_cross_reference: NCI:C33578

Thyrotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000709
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: Cell, TSH
Synonym: Pituitary TSH Producing Cells
Synonym: Pituitary TSH Secreting Cells
Synonym: Pituitary TSH-Producing Cell
Synonym: Pituitary TSH-Producing Cells
Synonym: Pituitary TSH-Secreting Cell
Synonym: Pituitary TSH-Secreting Cells
Synonym: Pituitary thyrotropic cell
Synonym: TSH Cell
Synonym: TSH Cells
Tree Number: T2.11.12
Tree Number: T2.12.34
database_cross_reference: FMA:83099
database_cross_reference: MSH:D052684
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33786

Melanotrophs
type: Class
subclass of: Endocrine Cells
subclass of: Epithelial Cells
PMOID: PMO:00000710
Subclass_of: Endocrine Cells
Subclass_of: Epithelial Cells
Synonym: MSH-Producing Cells, Pituitary
Synonym: Melanotroph
Synonym: Melanotropin-Producing Cell, Pituitary
Synonym: Melanotropin-Producing Cells, Pituitary
Synonym: Pituitary MSH Producing Cells
Synonym: Pituitary MSH-Producing Cell
Synonym: Pituitary MSH-Producing Cells
Synonym: Pituitary Melanotropin Producing Cells
Synonym: Pituitary Melanotropin-Producing Cell
Synonym: Pituitary Melanotropin-Producing Cells
Tree Number: T2.11.13
Tree Number: T2.12.35
database_cross_reference: MSH:D052717

Neuroendocrine Cells
type: Class
subclass of: Endocrine Cells
PMOID: PMO:00000711
Subclass_of: Endocrine Cells
Synonym: Cell, Neuroendocrine
Synonym: Cells, Neuroendocrine
Synonym: Endocrine Neuron
Synonym: Endocrine Neurons
Synonym: Neuroendocrine Cell
Synonym: Neuroendocrine cell
Synonym: Neuron, Endocrine
Synonym: Neurons, Endocrine
Tree Number: T2.11.14
database_cross_reference: FMA:83810
database_cross_reference: MSH:D055099
database_cross_reference: NCI:C12485

Epithelial Cells
type: Class
subclass of: Cell
PMOID: PMO:00000712
Subclass_of: Cell
Synonym: Cell, Epithelial
Synonym: Cells, Epithelial
Synonym: Epithelial Cell
Synonym: Epithelial cell
Synonym: Epithelial cell (body structure)
Synonym: Epithelial cell (cell)
Synonym: Epithelial cell, NOS
Synonym: Epithelial cells
Synonym: Epitheliocyte
Synonym: cell epithelial
Tree Number: T2.12
database_cross_reference: AOD:0000016923
database_cross_reference: CHV:0000004577
database_cross_reference: FMA:66768
database_cross_reference: LCH_NW:sh85044464
database_cross_reference: LNC:LA12887-8
database_cross_reference: LNC:LP14043-1
database_cross_reference: LNC:MTHU003158
database_cross_reference: MSH:D004847
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12578
database_cross_reference: PSY:17720
database_cross_reference: RCD:X76yI
database_cross_reference: SNMI:T-00251
database_cross_reference: SNOMEDCT_US:4212006
database_cross_reference: UWDA:66768

Thyroid Epithelial Cells
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000713
Subclass_of: Epithelial Cells
Synonym: Cell, Thyroid Epithelial
Synonym: Cell, Thyroid Follicular
Synonym: Cells, Thyroid Epithelial
Synonym: Cells, Thyroid Follicular
Synonym: Epithelial Cell, Thyroid
Synonym: Epithelial Cells, Thyroid
Synonym: Follicular Cell, Thyroid
Synonym: Follicular Cells, Thyroid
Synonym: Follicular cell of thyroid gland
Synonym: Principal cell of thyroid gland
Tree Number: T2.12.2
database_cross_reference: CHV:0000055928
database_cross_reference: FMA:68782
database_cross_reference: MSH:D000072637
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33783
database_cross_reference: NCI_NCI-GLOSS:CDR0000044543
database_cross_reference: UWDA:68782

Ameloblasts
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000714
Subclass_of: Epithelial Cells
Synonym: Ameloblast
Synonym: ameloblast
Tree Number: T2.12.3
database_cross_reference: CHV:0000000987
database_cross_reference: CSP:0835-5453
database_cross_reference: FMA:70576
database_cross_reference: MSH:D000565
database_cross_reference: NCI:C12579
database_cross_reference: UWDA:70576

Chromatophores
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000715
Subclass_of: Epithelial Cells
Synonym: Chromatophore
Synonym: chromatophore
Tree Number: T2.12.4
database_cross_reference: CSP:2328-1137
database_cross_reference: LCH:U001008
database_cross_reference: LCH_NW:sh85025337
database_cross_reference: MSH:D002856
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12581

Melanophores
type: Class
subclass of: Chromatophores
PMOID: PMO:00000716
Subclass_of: Chromatophores
Synonym: Melanophore
Tree Number: T2.12.4.1
database_cross_reference: LCH:U002890
database_cross_reference: LCH_NW:sh85083385
database_cross_reference: MSH:D008547
database_cross_reference: NCI:C12582

Labyrinth Supporting Cells
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000717
Subclass_of: Epithelial Cells
Synonym: Cell of Cladius
Synonym: Cell, Labyrinth Supporting
Synonym: Cells, Labyrinth Supporting
Synonym: External supporting cell of organ of Corti
Synonym: Labyrinth Supporting Cell
Synonym: Outer Phalangeal Cell
Synonym: Outer Supporting Cell
Synonym: Outer supporting cell
Synonym: Structure of supporting cell of organ of Corti
Synonym: Structure of supporting cell of organ of Corti (body structure)
Tree Number: T2.12.8
database_cross_reference: FMA:79802
database_cross_reference: MSH:D007760
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12590
database_cross_reference: NCI:C33240
database_cross_reference: SNM:T-XY783
database_cross_reference: SNMI:T-AB783
database_cross_reference: SNOMEDCT_US:28199004

Melanocytes
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000718
Subclass_of: Epithelial Cells
Synonym: Melanocyte
Synonym: Melanocyte (cell)
Synonym: melanocyte
Synonym: melanocytes
Tree Number: T2.12.11
database_cross_reference: AOD:0000017122
database_cross_reference: CHV:0000007893
database_cross_reference: CSP:2328-1309
database_cross_reference: FMA:70545
database_cross_reference: LCH:U002888
database_cross_reference: LCH_NW:sh85083380
database_cross_reference: MSH:D008544
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12591
database_cross_reference: NCI_NCI-GLOSS:CDR0000046292
database_cross_reference: SNM:T-01151
database_cross_reference: SNMI:T-01151
database_cross_reference: SNOMEDCT_US:9683001

Keratinocytes
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000719
Subclass_of: Epithelial Cells
Synonym: KERATINOCYTE
Synonym: Keratinized cell of epidermis
Synonym: Keratinocyte
Synonym: Keratinocyte (cell)
Synonym: Keratinocytes [Chemical/Ingredient]
Synonym: keratinocyte
Synonym: keratinocytes
Tree Number: T2.12.15
database_cross_reference: CHV:0000007051
database_cross_reference: CSP:2716-1254
database_cross_reference: FMA:62879
database_cross_reference: LCH_NW:sh85072034
database_cross_reference: MSH:D015603
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12589
database_cross_reference: NCI_CDISC:C12589
database_cross_reference: NDFRT:N0000184312
database_cross_reference: SNM:T-01152
database_cross_reference: SNMI:T-01152
database_cross_reference: SNOMEDCT_US:74447004
database_cross_reference: UWDA:62879

Merkel Cells
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000720
Subclass_of: Epithelial Cells
Synonym: Cells, Merkel
Synonym: MERKEL RECEPT
Synonym: MERKELS RECEPT
Synonym: Merkel Cell
Synonym: Merkel Receptor
Synonym: Merkel Receptors
Synonym: Merkel cell
Synonym: Merkel cells
Synonym: Merkel's Receptor
Synonym: Merkel's Receptors
Tree Number: T2.12.18
database_cross_reference: CHV:0000020727
database_cross_reference: FMA:70548
database_cross_reference: LCH_NW:sh00000072
database_cross_reference: MSH:D018862
database_cross_reference: NCI:C12592
database_cross_reference: NCI_NCI-GLOSS:CDR0000674683
database_cross_reference: SNM:T-01154
database_cross_reference: SNMI:T-01154
database_cross_reference: SNOMEDCT_US:10149001
database_cross_reference: UWDA:70548

Hepatocytes
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000721
Subclass_of: Epithelial Cells
Synonym: Cell, Hepatic
Synonym: Cells, Hepatic
Synonym: Hepatic Cell
Synonym: Hepatic Cells
Synonym: Hepatic Parenchymal Cell
Synonym: Hepatic parenchymal cell
Synonym: Hepatic parenchymal cell (body structure)
Synonym: Hepatic parenchymal cell (cell)
Synonym: Hepatocyte
Synonym: Hepatocytus
Tree Number: T2.12.26
database_cross_reference: AOD:0000017315
database_cross_reference: AOD:0000017316
database_cross_reference: CHV:0000022135
database_cross_reference: CSP:1754-0682
database_cross_reference: FMA:14515
database_cross_reference: FMA:63179
database_cross_reference: LCH_NW:sh85077772
database_cross_reference: LNC:LP68387-7
database_cross_reference: MSH:D022781
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12588
database_cross_reference: NCI_NCI-GLOSS:CDR0000046364
database_cross_reference: SNM:T-56260
database_cross_reference: SNMI:T-62260
database_cross_reference: SNOMEDCT_US:30396005
database_cross_reference: UWDA:14515
database_cross_reference: UWDA:63179

Endothelial Cells
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000722
Subclass_of: Epithelial Cells
Synonym: Cell, Endothelial
Synonym: Cells, Endothelial
Synonym: Endothelial Cell
Synonym: Endothelial cell
Synonym: Endothelial cell (body structure)
Synonym: Endothelial cell (cell)
Synonym: Endothelial cells
Synonym: Endotheliocyte
Synonym: cell endothelial
Synonym: cells endothelial
Tree Number: T2.12.27
database_cross_reference: AOD:0000016937
database_cross_reference: CHV:0000021886
database_cross_reference: FMA:66772
database_cross_reference: LCH_NW:sh2012001927
database_cross_reference: LNC:LP99346-6
database_cross_reference: MSH:D042783
database_cross_reference: NCI:C12865
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000044203
database_cross_reference: SNM:T-05130
database_cross_reference: SNMI:T-1A131
database_cross_reference: SNOMEDCT_US:45709008
database_cross_reference: UWDA:66772

Hemangioblasts
type: Class
subclass of: Hematopoietic Stem Cells
subclass of: Endothelial Cells
PMOID: PMO:00000723
Subclass_of: Endothelial Cells
Subclass_of: Hematopoietic Stem Cells
Synonym: Hemangioblast
Tree Number: T2.12.27.2
Tree Number: T2.34.2.4
database_cross_reference: MSH:D055018

Human Umbilical Vein Endothelial Cells
type: Class
subclass of: Endothelial Cells
PMOID: PMO:00000724
Subclass_of: Endothelial Cells
Synonym: Cell, HUVEC
Synonym: Cells, HUVEC
Synonym: Endothelial Cells, Human Umbilical Vein
Synonym: HUVEC Cell
Synonym: HUVEC Cells
Tree Number: T2.12.27.3
database_cross_reference: MSH:D061307

Neuroepithelial Cells
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000725
Subclass_of: Epithelial Cells
Synonym: Cell, Neuroepithelial
Synonym: Cells, Neuroepithelial
Synonym: Neuroepithelial Cell
Tree Number: T2.12.28
database_cross_reference: MSH:D046569
database_cross_reference: NCI:C41410

Neuroepithelial Bodies
type: Class
subclass of: Neuroepithelial Cells
PMOID: PMO:00000726
Subclass_of: Neuroepithelial Cells
Synonym: Bodies, Neuroepithelial
Synonym: Body, Neuroepithelial
Synonym: Neuroepithelial Body
Tree Number: T2.12.28.1
database_cross_reference: MSH:D046568

Podocytes
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000727
Subclass_of: Epithelial Cells
Synonym: Epithelial Cells, Glomerular Visceral
Synonym: Glomerular Visceral Epithelial Cells
Synonym: Podocyte
Synonym: Visceral Epithelial Cell
Synonym: Visceral Epithelial Cells, Glomerular
Synonym: glomerular visceral epithelial cell
Synonym: podocyte
Synonym: visceral glomerular epithelial cell
Tree Number: T2.12.29
database_cross_reference: CSP:5004-0066
database_cross_reference: MSH:D050199
database_cross_reference: NCI:C33334

Alveolar Epithelial Cells
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000728
Subclass_of: Epithelial Cells
Synonym: Alveolar Cell
Synonym: Alveolar Cells
Synonym: Alveolar Epithelial Cell
Synonym: Alveolar cell
Synonym: Alveolar epithelial cell
Synonym: Cell, Alveolar
Synonym: Cell, Alveolar Epithelial
Synonym: Cells, Alveolar
Synonym: Cells, Alveolar Epithelial
Synonym: Epithelial Cell, Alveolar
Tree Number: T2.12.36
database_cross_reference: CHV:0000021934
database_cross_reference: CSP:2612-4512
database_cross_reference: FMA:62499
database_cross_reference: MSH:D056809
database_cross_reference: NCI:C32053
database_cross_reference: SNM:T-28050
database_cross_reference: SNMI:T-28050
database_cross_reference: SNOMEDCT_US:47438009
database_cross_reference: UWDA:62499

Atypical Squamous Cells of the Cervix
type: Class
subclass of: Epithelial Cells
PMOID: PMO:00000729
Subclass_of: Epithelial Cells
Tree Number: T2.12.39

Erythroid Cells
type: Class
subclass of: Cell
PMOID: PMO:00000730
Subclass_of: Cell
Synonym: Cell, Erythroid
Synonym: Cells, Erythroid
Synonym: Erythroid Cell
Synonym: Erythroid cell
Synonym: Erythroid cell (cell)
Synonym: Erythroid cells
Synonym: Erythropoietic cell
Synonym: erythroid cell
Synonym: erythroid cells
Tree Number: T2.13
database_cross_reference: CHV:0000056249
database_cross_reference: FMA:83516
database_cross_reference: LNC:LP32048-8
database_cross_reference: LNC:LP35614-4
database_cross_reference: LNC:MTHU030086
database_cross_reference: MSH:D041905
database_cross_reference: SNOMEDCT_US:414128005

Eukaryotic Cells
type: Class
subclass of: Cell
PMOID: PMO:00000731
Subclass_of: Cell
Tree Number: T2.14

Germ Cells
type: Class
subclass of: Cell
PMOID: PMO:00000732
Subclass_of: Cell
Synonym: Cell, Germ
Synonym: Cell, Germ-Line
Synonym: Cells, Germ
Synonym: Cells, Germ-Line
Synonym: Gamete
Synonym: Gametes
Synonym: Germ Cell
Synonym: Germ Line Cells
Synonym: Germ cell
Synonym: Germ cells
Tree Number: T2.15
database_cross_reference: AOD:0000021975
database_cross_reference: AOD:0000021976
database_cross_reference: CHV:0000005470
database_cross_reference: CSP:1138-4561
database_cross_reference: FMA:18649
database_cross_reference: LCH:U001951
database_cross_reference: LCH_NW:sh85054322
database_cross_reference: MSH:D005854
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12597
database_cross_reference: NCI_NCI-GLOSS:CDR0000046382
database_cross_reference: NCI_NCI-GLOSS:CDR0000046563
database_cross_reference: UWDA:18649

Embryonic Germ Cells
type: Class
subclass of: Germ Cells
subclass of: Embryonic Stem Cells
PMOID: PMO:00000733
Subclass_of: Embryonic Stem Cells
Subclass_of: Germ Cells
Synonym: Cell, EG
Synonym: Cell, Embryonic Germ
Synonym: Cells, EG
Synonym: Cells, Embryonic Germ
Synonym: EG Cell
Synonym: EG Cells
Synonym: Embryonic Germ Cell
Synonym: Germ Cell, Embryonic
Synonym: Germ Cells, Embryonic
Tree Number: T2.15.1
Tree Number: T2.34.7.1.3
database_cross_reference: MSH:D000066473

Oocytes
type: Class
subclass of: Ovum
PMOID: PMO:00000734
Subclass_of: Ovum
Synonym: Oocyte
Synonym: Oocyte (cell)
Synonym: Oocyte, NOS
Synonym: Ovocyte
Synonym: Ovocyte, NOS
Synonym: Ovocytes
Synonym: cells oocytes
Synonym: oocyte
Synonym: oocyte (cell)
Synonym: oocytes
Tree Number: T2.15.2.1
database_cross_reference: AOD:0000002597
database_cross_reference: AOD:0000021972
database_cross_reference: CHV:0000008953
database_cross_reference: CSP:1138-3157
database_cross_reference: FMA:18644
database_cross_reference: MSH:D009865
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12598
database_cross_reference: SNMI:T-87509
database_cross_reference: SNOMEDCT_US:86082002
database_cross_reference: UWDA:18644

Polar Bodies
type: Class
subclass of: Oocytes
PMOID: PMO:00000735
Subclass_of: Oocytes
Synonym: Bodies, Polar
Synonym: Body, Polar
Synonym: Cell, Polar
Synonym: Cells, Polar
Synonym: Polar Body
Synonym: Polar Cell
Synonym: Polar Cells
Synonym: Polar body
Tree Number: T2.15.2.1.1
database_cross_reference: FMA:85543
database_cross_reference: MSH:D059705

Oogonia
type: Class
subclass of: Ovum
PMOID: PMO:00000736
Subclass_of: Ovum
Synonym: Oogonium
Synonym: Ovocytus primarium
Synonym: Primary Oocyte
Synonym: Primary oocyte
Synonym: Primordial Ovum
Synonym: Primordial ovum
Synonym: Primordial ovum (cell)
Synonym: oogonium (cell)
Tree Number: T2.15.2.2
database_cross_reference: AOD:0000002595
database_cross_reference: FMA:18645
database_cross_reference: FMA:83673
database_cross_reference: MSH:D009867
database_cross_reference: NCI:C12600
database_cross_reference: SNM:T-87510
database_cross_reference: SNMI:T-87510
database_cross_reference: SNOMEDCT_US:78829006
database_cross_reference: UWDA:18645

Spermatozoa
type: Class
subclass of: Germ Cells
PMOID: PMO:00000737
Subclass_of: Germ Cells
Synonym: Androcyte
Synonym: Mature sperm cell
Synonym: SPERMATOZOON
Synonym: Sperm
Synonym: Sperm Cell
Synonym: Sperm cell
Synonym: Spermatic
Synonym: Spermatozoa (cell)
Synonym: Spermatozoon
Synonym: Spermium
Tree Number: T2.15.3
database_cross_reference: AOD:0000001999
database_cross_reference: AOD:0000021999
database_cross_reference: AOD:0000022001
database_cross_reference: AOD:0000022002
database_cross_reference: AOD:0000022004
database_cross_reference: AOD:0000022005
database_cross_reference: CHV:0000011591
database_cross_reference: CSP:1138-6433
database_cross_reference: FMA:67338
database_cross_reference: FMA:72290
database_cross_reference: LCH:U004418
database_cross_reference: LCH_NW:sh85126546
database_cross_reference: LNC:LA12898-5
database_cross_reference: LNC:LP14765-9
database_cross_reference: LNC:LP7599-6
database_cross_reference: LNC:MTHU001966
database_cross_reference: LNC:MTHU042523
database_cross_reference: MSH:D013094
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12602
database_cross_reference: NCI_CDISC:C12602
database_cross_reference: NCI_NCI-GLOSS:CDR0000257221
database_cross_reference: PSY:49230
database_cross_reference: SNM:T-78180
database_cross_reference: SNMI:T-94180
database_cross_reference: SNOMEDCT_US:6789008
database_cross_reference: UWDA:67338
database_cross_reference: UWDA:72290

Sperm Head
type: Class
subclass of: Spermatozoa
PMOID: PMO:00000738
Subclass_of: Spermatozoa
Synonym: Caput (Spermatozoon)
Synonym: Caput of sperm
Synonym: Caput of spermatozoon
Synonym: Head of sperm
Synonym: Head of spermatozoon
Synonym: Head of the Spermatozoon
Synonym: Head, Sperm
Synonym: Heads, Sperm
Synonym: Sperm Heads
Synonym: Spermatozoa.head
Tree Number: T2.15.3.1
database_cross_reference: FMA:67376
database_cross_reference: LNC:LP34798-6
database_cross_reference: MSH:D013077
database_cross_reference: NCI:C12603
database_cross_reference: UWDA:67376

Spermatids
type: Class
subclass of: Spermatozoa
PMOID: PMO:00000739
Subclass_of: Spermatozoa
Synonym: Nematoblast
Synonym: Spermatid
Synonym: Spermatid (cell)
Synonym: Spermatoblast
Synonym: Spermatoblasts
Synonym: Spermoblast
Synonym: nematoblast
Synonym: spermatid
Synonym: spermatoblast
Synonym: spermid
Tree Number: T2.15.3.3
database_cross_reference: AOD:0000002606
database_cross_reference: AOD:0000021996
database_cross_reference: AOD:0000021997
database_cross_reference: AOD:0000021998
database_cross_reference: AOD:0000022000
database_cross_reference: FMA:72294
database_cross_reference: LNC:LP34676-4
database_cross_reference: LNC:MTHU024958
database_cross_reference: MSH:D013087
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12604
database_cross_reference: SNM:T-78170
database_cross_reference: SNMI:T-94170
database_cross_reference: SNOMEDCT_US:38326003
database_cross_reference: UWDA:72294

Spermatocytes
type: Class
subclass of: Spermatozoa
PMOID: PMO:00000740
Subclass_of: Spermatozoa
Synonym: Spermatocyte
Synonym: Spermiocyte
Synonym: Spermiocytes
Synonym: spermatocyte
Tree Number: T2.15.3.4
database_cross_reference: AOD:0000002607
database_cross_reference: FMA:84049
database_cross_reference: LNC:LP32764-0
database_cross_reference: MSH:D013090
database_cross_reference: NCI:C12605

Spermatogonia
type: Class
subclass of: Spermatozoa
PMOID: PMO:00000741
Subclass_of: Spermatozoa
Synonym: Primitive sperm cell
Synonym: Spermatogonia (cell)
Synonym: Spermatogonias
Synonym: Spermatogonium
Synonym: Spermatophore
Synonym: Spermatophores
Synonym: cells spermatogonia
Synonym: spermatogone
Synonym: spermatogonia
Synonym: spermatogonium
Tree Number: T2.15.3.5
database_cross_reference: AOD:0000002605
database_cross_reference: AOD:0000021992
database_cross_reference: AOD:0000021993
database_cross_reference: AOD:0000021994
database_cross_reference: AOD:0000021995
database_cross_reference: CHV:0000011590
database_cross_reference: FMA:72291
database_cross_reference: LCH_NW:sh85126544
database_cross_reference: LNC:LP14757-6
database_cross_reference: LNC:MTHU001958
database_cross_reference: MSH:D013093
database_cross_reference: NCI:C12606
database_cross_reference: SNM:T-78140
database_cross_reference: SNMI:T-94140
database_cross_reference: SNOMEDCT_US:67807008
database_cross_reference: UWDA:72291

Sperm Midpiece
type: Class
subclass of: Spermatozoa
PMOID: PMO:00000742
Subclass_of: Spermatozoa
Synonym: Midpiece, Sperm
Synonym: Midpieces, Sperm
Synonym: Sperm Midpieces
Synonym: Spermatozoa.midpiece
Synonym: sperm midpiece
Tree Number: T2.15.3.6
database_cross_reference: GO:GO:0097225
database_cross_reference: LNC:LP34799-4
database_cross_reference: MSH:D032961

Germ Cells, Plant
type: Class
subclass of: Germ Cells
PMOID: PMO:00000743
Subclass_of: Germ Cells
Tree Number: T2.15.4

Giant Cells
type: Class
subclass of: Cell
PMOID: PMO:00000744
Subclass_of: Cell
Synonym: Abnormal numbers of nuclei
Synonym: Cell, Giant
Synonym: Cell, Multinucleated Giant
Synonym: Cells, Giant
Synonym: Cells, Multinucleated Giant
Synonym: Giant Cell
Synonym: Giant Cell, Multinucleated
Synonym: Giant Cells, Multinucleated
Synonym: Giant cell
Synonym: Giant cell, NOS
Tree Number: T2.16
database_cross_reference: CHV:0000005484
database_cross_reference: FMA:83623
database_cross_reference: MSH:D015726
database_cross_reference: NCI:C12607
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_CDISC:C12607
database_cross_reference: NCI_NCI-GLOSS:CDR0000044625
database_cross_reference: SNM:M-69210
database_cross_reference: SNM:M-69430
database_cross_reference: SNM:T-06550
database_cross_reference: SNMI:M-62500
database_cross_reference: SNMI:T-C1550
database_cross_reference: SNOMEDCT_US:60401004
database_cross_reference: SNOMEDCT_US:81480003
database_cross_reference: SNOMEDCT_VET:45441000009108

Hepatic Stellate Cells
type: Class
subclass of: Cell
PMOID: PMO:00000745
Subclass_of: Cell
Synonym: Cell, Hepatic Stellate
Synonym: Cells, Hepatic Stellate
Synonym: Hepatic Stellate Cell
Synonym: Stellate Cell, Hepatic
Synonym: Stellate Cells, Hepatic
Synonym: cell hepatic stellate
Synonym: cells hepatic stellate
Synonym: hepatic stellate cell
Tree Number: T2.17
database_cross_reference: AOD:0000017325
database_cross_reference: CHV:0000049344
database_cross_reference: MSH:D055166
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32734

Mesophyll Cells
type: Class
subclass of: Cell
PMOID: PMO:00000746
Subclass_of: Cell
Synonym: Cell, Mesophyll
Synonym: Cells, Mesophyll
Synonym: Mesophyll Cell
Tree Number: T2.18
database_cross_reference: MSH:D058503

Muscle Cells
type: Class
subclass of: Cell
PMOID: PMO:00000747
Subclass_of: Cell
Synonym: Mature Muscle Cell
Synonym: Mature Muscle Cells
Synonym: Muscle Cell
Synonym: Muscle Cell, Mature
Synonym: Muscle Cells, Mature
Synonym: Muscle cell
Synonym: Muscle cells
Synonym: Myocyte
Synonym: Myocytes
Synonym: cell muscle
Tree Number: T2.19
database_cross_reference: AOD:0000016896
database_cross_reference: AOD:0000027638
database_cross_reference: CHV:0000041649
database_cross_reference: CSP:1975-6404
database_cross_reference: FMA:67328
database_cross_reference: LCH_NW:sh85088676
database_cross_reference: MSH:D032342
database_cross_reference: NCI:C12612
database_cross_reference: UWDA:67328

Myocytes, Smooth Muscle
type: Class
subclass of: Muscle Cells
PMOID: PMO:00000748
Subclass_of: Muscle Cells
Synonym: Cell, Smooth Muscle
Synonym: Cells, Smooth Muscle
Synonym: Leiomyocyte
Synonym: Myocyte of smooth muscle
Synonym: Myocyte, Smooth Muscle
Synonym: Myocytus nonstriatus
Synonym: Non-striated muscle fiber
Synonym: Smooth Muscle Cell
Synonym: Smooth Muscle Cells
Synonym: Smooth Muscle Myocyte
Tree Number: T2.19.3
database_cross_reference: CHV:0000054912
database_cross_reference: FMA:14072
database_cross_reference: GO:GO:0030485
database_cross_reference: MSH:D032389
database_cross_reference: NCI:C13001
database_cross_reference: UWDA:14072

Interstitial Cells of Cajal
type: Class
subclass of: Muscle Cells
PMOID: PMO:00000749
Subclass_of: Muscle Cells
Synonym: Cajal Interstitial Cells
Synonym: ICC (Interstitial cell of Cajal)
Synonym: Interstitial Cell of Cajal
Synonym: Interstitial cell of Cajal
Synonym: gastrointestinal pacemaker cell
Synonym: interstitial cell of Cajal
Tree Number: T2.19.4
database_cross_reference: CSP:5006-0020
database_cross_reference: FMA:86573
database_cross_reference: MSH:D056885
database_cross_reference: NCI:C32871

Myeloid Cells
type: Class
subclass of: Cell
PMOID: PMO:00000750
Subclass_of: Cell
Synonym: Cell, Myeloid
Synonym: Cells, Myeloid
Synonym: Myeloid Cell
Synonym: Myeloid cells
Synonym: myeloid cell
Synonym: myeloid cells
Tree Number: T2.20
database_cross_reference: CHV:0000052271
database_cross_reference: LNC:LP15094-3
database_cross_reference: MSH:D022423
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12549

Myeloid-Derived Suppressor Cells
type: Class
subclass of: Myeloid Cells
PMOID: PMO:00000751
Subclass_of: Myeloid Cells
Synonym: Cell, Myeloid-Derived Suppressor
Synonym: Cells, Myeloid-Derived Suppressor
Synonym: MDSCs
Synonym: Myeloid Derived Suppressor Cells
Synonym: Myeloid-Derived Suppressor Cell
Synonym: Suppressor Cell, Myeloid-Derived
Synonym: Suppressor Cells, Myeloid-Derived
Tree Number: T2.20.1
database_cross_reference: MSH:D000072737

Neoplastic Cells, Circulating
type: Class
subclass of: Cell
PMOID: PMO:00000752
Subclass_of: Cell
Synonym: CELLS NEOPL CIRC
Synonym: CIRC CELLS NEOPL
Synonym: CIRCULATING TUMOR CELL
Synonym: CTC
Synonym: Cell, Circulating Neoplastic
Synonym: Cell, Circulating Tumor
Synonym: Cell, Neoplasm Circulating
Synonym: Cells, Circulating Neoplastic
Synonym: Cells, Circulating Tumor
Synonym: Cells, Neoplasm Circulating
Tree Number: T2.21
database_cross_reference: CSP:2027-2462
database_cross_reference: LNC:LP133414-5
database_cross_reference: LNC:LP135291-5
database_cross_reference: MSH:D009360
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C63797
database_cross_reference: NCI_CDISC:C63797
database_cross_reference: NDFRT:N0000002122

Neuroglia
type: Class
subclass of: Cell
PMOID: PMO:00000753
Subclass_of: Cell
Synonym: A04 GLIA
Synonym: Cell, Glial
Synonym: Cell, Neuroglial
Synonym: Cells, Glial
Synonym: Cells, Neuroglial
Synonym: GLIA
Synonym: Glia
Synonym: Glia (body structure)
Synonym: Glial
Synonym: Glial Cell
Tree Number: T2.22
database_cross_reference: AOD:0000017751
database_cross_reference: AOD:0000028027
database_cross_reference: AOD:0000028029
database_cross_reference: AOD:0000028030
database_cross_reference: CHV:0000008637
database_cross_reference: CHV:0000037943
database_cross_reference: CSP:2047-3472
database_cross_reference: FMA:54536
database_cross_reference: FMA:54541
database_cross_reference: LCH:U003190
database_cross_reference: LCH_NW:sh85091124
database_cross_reference: MSH:D009457
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12615
database_cross_reference: NCI_NCI-GLOSS:CDR0000269440
database_cross_reference: NCI_NCI-GLOSS:CDR0000572232
database_cross_reference: SNM:T-X0400
database_cross_reference: SNM:U000495
database_cross_reference: SNMI:T-A0400
database_cross_reference: SNMI:T-A0405
database_cross_reference: SNOMEDCT_US:2156000
database_cross_reference: SNOMEDCT_US:58861006
database_cross_reference: UWDA:54541

Oligodendrocyte Precursor Cells
type: Class
subclass of: Neuroglia
subclass of: Neural Stem Cells
PMOID: PMO:00000754
Subclass_of: Neural Stem Cells
Subclass_of: Neuroglia
Tree Number: T2.22.1
Tree Number: T2.34.10.1

Astrocytes
type: Class
subclass of: Neuroglia
PMOID: PMO:00000755
Subclass_of: Neuroglia
Synonym: Astrocyte
Synonym: Astrocyte (cell)
Synonym: Astrocyte, NOS
Synonym: Astrocytus
Synonym: Astroglia
Synonym: Astroglias
Synonym: astrocyte
Synonym: astrocyte cells
Synonym: astrocytes
Synonym: astroglia
Tree Number: T2.22.2
database_cross_reference: AOD:0000017757
database_cross_reference: CHV:0000001545
database_cross_reference: CSP:2047-3484
database_cross_reference: FMA:54537
database_cross_reference: LCH:U000408
database_cross_reference: LCH_NW:sh85008884
database_cross_reference: MSH:D001253
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12477
database_cross_reference: NCI:TCGA
database_cross_reference: NCI_NCI-GLOSS:CDR0000269436
database_cross_reference: OMIM:MTHU031932
database_cross_reference: SNM:T-X0420
database_cross_reference: SNMI:T-A0420
database_cross_reference: SNOMEDCT_US:78399007

Oligodendroglia
type: Class
subclass of: Neuroglia
PMOID: PMO:00000756
Subclass_of: Neuroglia
Synonym: Oligodendrocyte
Synonym: Oligodendrocyte (cell)
Synonym: Oligodendrocytes
Synonym: Oligodendrocytus
Synonym: Oligodendroglia Cell
Synonym: Oligodendroglia cell
Synonym: Oligodendroglial cell
Synonym: cells oligodendrocytes
Synonym: oligodendrocyte
Synonym: oligodendrocytes
Tree Number: T2.22.3
database_cross_reference: AOD:0000017761
database_cross_reference: AOD:0000028032
database_cross_reference: CHV:0000008929
database_cross_reference: CSP:2047-3506
database_cross_reference: FMA:54540
database_cross_reference: FMA:83665
database_cross_reference: LCH:U003336
database_cross_reference: LCH_NW:sh85094602
database_cross_reference: MSH:D009836
database_cross_reference: NCI:C12618
database_cross_reference: NCI_NCI-GLOSS:CDR0000540447
database_cross_reference: SNM:T-X0450
database_cross_reference: SNMI:T-A0450
database_cross_reference: SNOMEDCT_US:66254009

Schwann Cells
type: Class
subclass of: Neuroglia
PMOID: PMO:00000757
Subclass_of: Neuroglia
Synonym: Cells, Schwann
Synonym: Neurilemma Cell
Synonym: Neurilemma cell
Synonym: Neurilemma cell (body structure)
Synonym: Neurilemma cell (cell)
Synonym: Neurilemmal Cell
Synonym: Neurilemmal cell
Synonym: Peripheral glial cell
Synonym: Peripheral neuroglial cell
Synonym: Schwann Cell
Tree Number: T2.22.4
database_cross_reference: AOD:0000017753
database_cross_reference: CHV:0000011105
database_cross_reference: CSP:2049-8500
database_cross_reference: FMA:62121
database_cross_reference: MSH:D012583
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12620
database_cross_reference: NCI_NCI-GLOSS:CDR0000269452
database_cross_reference: SNM:T-X0520
database_cross_reference: SNMI:T-A0520
database_cross_reference: SNOMEDCT_US:44591005

Microglia
type: Class
subclass of: Neuroglia
PMOID: PMO:00000758
Subclass_of: Neuroglia
Synonym: Gitter cell
Synonym: Hortega cell
Synonym: Microglial Cell
Synonym: Microglial cell
Synonym: Microglial cells set
Synonym: Microgliocyte
Synonym: Microgliocyte (cell)
Synonym: Set of microglial cells
Synonym: Small glial cell
Synonym: gitter cell
Tree Number: T2.22.5
database_cross_reference: AOD:0000017762
database_cross_reference: AOD:0000028033
database_cross_reference: AOD:0000028037
database_cross_reference: AOD:0000028039
database_cross_reference: AOD:0000028041
database_cross_reference: CHV:0000020811
database_cross_reference: CSP:2047-3495
database_cross_reference: FMA:54539
database_cross_reference: FMA:68923
database_cross_reference: LCH_NW:sh85084845
database_cross_reference: MSH:D017628
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12616
database_cross_reference: SNM:M-69510
database_cross_reference: SNM:T-X0460
database_cross_reference: SNMI:T-A0460
database_cross_reference: SNOMEDCT_US:63483002
database_cross_reference: UWDA:68923

Neuropil
type: Class
subclass of: Neuroglia
subclass of: Neurons
PMOID: PMO:00000759
Subclass_of: Neuroglia
Subclass_of: Neurons
Synonym: Neuropil (body structure)
Synonym: Neuropile
Synonym: Neuropiles
Synonym: Neuropils
Synonym: neuropil
Synonym: neuropiles
Tree Number: T2.22.6
Tree Number: T2.23.16
database_cross_reference: CHV:0000022225
database_cross_reference: CSP:2047-3725
database_cross_reference: FMA:261269
database_cross_reference: MSH:D019581
database_cross_reference: NCI:C12617
database_cross_reference: SNM:T-X0310
database_cross_reference: SNMI:T-A0310
database_cross_reference: SNOMEDCT_US:67146008

Satellite Cells, Perineuronal
type: Class
subclass of: Neuroglia
PMOID: PMO:00000760
Subclass_of: Neuroglia
Synonym: Cell, Perineuronal Satellite
Synonym: Cells, Perineuronal Satellite
Synonym: Perineuronal Satellite Cell
Synonym: Perineuronal Satellite Cells
Synonym: Perineuronal satellite cell
Synonym: Perineuronal satellite cell (body structure)
Synonym: Perineuronal satellite cell (cell)
Synonym: Satellite Cell
Synonym: Satellite Cell, Perineuronal
Synonym: cell satellite
Tree Number: T2.22.7
database_cross_reference: CHV:0000020737
database_cross_reference: CSP:2047-3601
database_cross_reference: MSH:D027161
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12619
database_cross_reference: NCI:C33516
database_cross_reference: SNM:T-X0480
database_cross_reference: SNMI:T-A0480
database_cross_reference: SNOMEDCT_US:28922004

Ependymoglial Cells
type: Class
subclass of: Neuroglia
PMOID: PMO:00000761
Subclass_of: Neuroglia
Synonym: Cell, Ependymoglial
Synonym: Cells, Ependymoglial
Synonym: Ependymoglial Cell
Tree Number: T2.22.8
database_cross_reference: MSH:D063928
database_cross_reference: MTH:NOCODE

Neurons
type: Class
subclass of: Cell
PMOID: PMO:00000762
Subclass_of: Cell
Synonym: Cell, Nerve
Synonym: Cells, Nerve
Synonym: Nerve Cell
Synonym: Nerve Cells
Synonym: Nerve cell
Synonym: Neural Cell
Synonym: Neural cell
Synonym: Neurocyte
Synonym: Neuron
Synonym: Neuron (cell)
Tree Number: T2.23
database_cross_reference: AOD:0000017676
database_cross_reference: AOD:0000017677
database_cross_reference: AOD:0000027982
database_cross_reference: AOD:0000027983
database_cross_reference: AOD:0000027985
database_cross_reference: AOD:0000027986
database_cross_reference: AOD:0000027987
database_cross_reference: CHV:0000008658
database_cross_reference: CHV:0000043938
database_cross_reference: CSP:2047-3601
database_cross_reference: FMA:54527
database_cross_reference: FMA:70333
database_cross_reference: LCH:U003198
database_cross_reference: LCH_NW:sh85091153
database_cross_reference: MSH:D009474
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12623
database_cross_reference: NCI_NCI-GLOSS:CDR0000269443
database_cross_reference: NCI_NCI-GLOSS:CDR0000269444
database_cross_reference: PSY:33440
database_cross_reference: PSY:33770
database_cross_reference: SNM:T-X0210
database_cross_reference: SNMI:T-A0210
database_cross_reference: SNOMEDCT_US:47220008

Grid Cells
type: Class
subclass of: Neurons
PMOID: PMO:00000763
Subclass_of: Neurons
Synonym: Cell, Grid
Synonym: Cells, Grid
Synonym: Grid Cell
Tree Number: T2.23.1
database_cross_reference: MSH:D000071038

Suprachiasmatic Nucleus Neurons
type: Class
subclass of: Neurons
PMOID: PMO:00000764
Subclass_of: Neurons
Tree Number: T2.23.2

Mossy Fibers, Hippocampal
type: Class
subclass of: Axons
PMOID: PMO:00000765
Subclass_of: Axons
Synonym: Hippocampal Mossy Fiber
Synonym: Hippocampal Mossy Fibers
Synonym: Mossy Fiber, Hippocampal
Synonym: hippocampal mossy fiber
Tree Number: T2.23.3.3
database_cross_reference: GO:GO:0097457
database_cross_reference: MSH:D019599

Interneurons
type: Class
subclass of: Neurons
PMOID: PMO:00000766
Subclass_of: Neurons
Synonym: Connector Neuron
Synonym: Intercalary Neuron
Synonym: Intercalated Neuron
Synonym: Intercalated Neurons
Synonym: Interneuron
Synonym: Internuncial Cell
Synonym: Internuncial Neuron
Synonym: Neuron, Intercalated
Synonym: Neurons, Intercalated
Synonym: connector neuron
Tree Number: T2.23.5
database_cross_reference: AOD:0000017728
database_cross_reference: AOD:0000028013
database_cross_reference: AOD:0000028015
database_cross_reference: AOD:0000028017
database_cross_reference: AOD:0000028019
database_cross_reference: AOD:0000028020
database_cross_reference: CHV:0000006838
database_cross_reference: CSP:2047-3656
database_cross_reference: FMA:67313
database_cross_reference: MSH:D007395
database_cross_reference: NCI:C12625

Amacrine Cells
type: Class
subclass of: Interneurons
subclass of: Retinal Neurons
PMOID: PMO:00000767
Subclass_of: Interneurons
Subclass_of: Retinal Neurons
Synonym: Amacrine Cell
Synonym: Amacrine Cell of Retina
Synonym: Amacrine Cells of Retina
Synonym: Amacrine cell
Synonym: Amacrine cell of retina
Synonym: Amacrine cells of retina
Synonym: Amacrine cells of retina (body structure)
Synonym: Cell, Amacrine
Synonym: Cells, Amacrine
Synonym: Retina, amacrine cells
Tree Number: T2.23.5.1
Tree Number: T2.23.9.5.3
database_cross_reference: CSP:1111-4695
database_cross_reference: FMA:67766
database_cross_reference: MSH:D025042
database_cross_reference: NCI:C12626
database_cross_reference: SNM:T-XX675
database_cross_reference: SNMI:T-AA675
database_cross_reference: SNOMEDCT_US:9475001

Retinal Bipolar Cells
type: Class
subclass of: Interneurons
subclass of: Retinal Neurons
PMOID: PMO:00000768
Subclass_of: Interneurons
Subclass_of: Retinal Neurons
Synonym: Bipolar Cell, Retinal
Synonym: Bipolar Cells, Retinal
Synonym: Bipolar cell of retina
Synonym: Bipolar cells of retina
Synonym: Bipolar cells of retina (body structure)
Synonym: Cell, Retinal Bipolar
Synonym: Cells, Retinal Bipolar
Synonym: Retina, bipolar cells
Synonym: Retinal Bipolar Cell
Tree Number: T2.23.5.2
Tree Number: T2.23.9.5.4
database_cross_reference: FMA:67749
database_cross_reference: MSH:D051245
database_cross_reference: SNM:T-XX671
database_cross_reference: SNMI:T-AA671
database_cross_reference: SNOMEDCT_US:72060002

Renshaw Cells
type: Class
subclass of: Interneurons
PMOID: PMO:00000769
Subclass_of: Interneurons
Synonym: Cell, Renshaw
Synonym: Cells, Renshaw
Synonym: Interneurons, Renshaw
Synonym: Renshaw Cell
Synonym: Renshaw Interneurons
Synonym: Renshaw cell
Synonym: Spinal Cord Ventral Horn Interneuron Renshaw
Synonym: cells renshaw
Synonym: renshaw cell
Tree Number: T2.23.5.3
database_cross_reference: AOD:0000017731
database_cross_reference: CHV:0000043671
database_cross_reference: FMA:86787
database_cross_reference: MSH:D066293
database_cross_reference: NCI:C33463

Commissural Interneurons
type: Class
subclass of: Interneurons
PMOID: PMO:00000770
Subclass_of: Interneurons
Synonym: Commissural Interneuron
Synonym: Interneuron, Commissural
Synonym: Interneurons, Commissural
Tree Number: T2.23.5.4
database_cross_reference: MSH:D066294

Nerve Fibers
type: Class
subclass of: Neurons
PMOID: PMO:00000771
Subclass_of: Neurons
Synonym: Nerve Fiber
Synonym: Nerve fiber
Synonym: Nerve fiber (body structure)
Synonym: Nerve fiber, NOS
Synonym: Nerve fibre
Synonym: Neurofibra
Synonym: Neurofibrum
Synonym: fiber nerve
Synonym: fibers nerve
Synonym: fibres nerve
Tree Number: T2.23.6
database_cross_reference: AOD:0000027997
database_cross_reference: CHV:0000008598
database_cross_reference: FMA:5914
database_cross_reference: GO:GO:0043005
database_cross_reference: MSH:D009412
database_cross_reference: NCI:C32177
database_cross_reference: SNM:T-X0330
database_cross_reference: SNMI:T-A0330
database_cross_reference: SNOMEDCT_US:88545005
database_cross_reference: UWDA:5914

Adrenergic Fibers
type: Class
subclass of: Nerve Fibers
PMOID: PMO:00000772
Subclass_of: Nerve Fibers
Synonym: Adrenergic Fiber
Synonym: Fiber, Adrenergic
Synonym: Fiber, Sympathetic
Synonym: Fibers, Adrenergic
Synonym: Fibers, Sympathetic
Synonym: Sympathetic Fiber
Synonym: Sympathetic Fibers
Synonym: Sympathetic fiber
Synonym: Sympathetic fiber (body structure)
Synonym: Sympathetic fibre
Tree Number: T2.23.6.1
database_cross_reference: MSH:D000320
database_cross_reference: SNOMEDCT_US:361060001

Sympathetic Fibers, Postganglionic
type: Class
subclass of: Adrenergic Fibers
subclass of: Autonomic Fibers, Postganglionic
PMOID: PMO:00000773
Subclass_of: Adrenergic Fibers
Subclass_of: Autonomic Fibers, Postganglionic
Synonym: Fiber, Postganglionic Sympathetic
Synonym: Fibers, Postganglionic Sympathetic
Synonym: Postganglionic Sympathetic Fiber
Synonym: Postganglionic Sympathetic Fibers
Synonym: Postganglionic sympathetic fiber
Synonym: Postganglionic sympathetic fibre
Synonym: Structure of postganglionic sympathetic fiber
Synonym: Structure of postganglionic sympathetic fiber (body structure)
Synonym: Structure of postganglionic sympathetic fibre
Synonym: Sympathetic Fiber, Postganglionic
Tree Number: T2.23.6.1.1
Tree Number: T2.23.6.2.2
database_cross_reference: MSH:D017779
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12650
database_cross_reference: SNM:T-X9660
database_cross_reference: SNMI:T-A9660
database_cross_reference: SNOMEDCT_US:44821008

Autonomic Fibers, Postganglionic
type: Class
subclass of: Nerve Fibers
PMOID: PMO:00000774
Subclass_of: Nerve Fibers
Synonym: Autonomic Fiber, Postganglionic
Synonym: Fiber, Postganglionic Autonomic
Synonym: Fibers, Postganglionic Autonomic
Synonym: Postganglionic Autonomic Fiber
Synonym: Postganglionic Autonomic Fibers
Synonym: Postganglionic Fiber
Synonym: postganglionic fiber
Tree Number: T2.23.6.2
database_cross_reference: CSP:2049-9198
database_cross_reference: MSH:D001338
database_cross_reference: NCI:C12648
database_cross_reference: PSY:39680

Parasympathetic Fibers, Postganglionic
type: Class
subclass of: Autonomic Fibers, Postganglionic
subclass of: Cholinergic Fibers
PMOID: PMO:00000775
Subclass_of: Autonomic Fibers, Postganglionic
Subclass_of: Cholinergic Fibers
Synonym: Fiber, Postganglionic Parasympathetic
Synonym: Fibers, Postganglionic Parasympathetic
Synonym: Parasympathetic Fiber, Postganglionic
Synonym: Postganglionic Parasympathetic Fiber
Synonym: Postganglionic Parasympathetic Fibers
Tree Number: T2.23.21.1.2
Tree Number: T2.23.6.2.1
Tree Number: T2.23.6.4.2
database_cross_reference: MSH:D017777
database_cross_reference: NCI:C12649

Cholinergic Fibers
type: Class
subclass of: Nerve Fibers
subclass of: Cholinergic Neurons
PMOID: PMO:00000776
Subclass_of: Cholinergic Neurons
Subclass_of: Nerve Fibers
Synonym: Cholinergic Fiber
Synonym: Fiber, Cholinergic
Synonym: Fibers, Cholinergic
Tree Number: T2.23.21.1
Tree Number: T2.23.6.4
database_cross_reference: MSH:D002799

Autonomic Fibers, Preganglionic
type: Class
subclass of: Cholinergic Fibers
PMOID: PMO:00000777
Subclass_of: Cholinergic Fibers
Synonym: Autonomic Fiber, Preganglionic
Synonym: Fiber, Preganglionic Autonomic
Synonym: Fibers, Preganglionic Autonomic
Synonym: Preganglionic Autonomic Fiber
Synonym: Preganglionic Autonomic Fibers
Synonym: Preganglionic Fiber
Synonym: preganglionic fiber
Tree Number: T2.23.21.1.1
Tree Number: T2.23.6.4.1
database_cross_reference: CSP:2049-9205
database_cross_reference: MSH:D001339
database_cross_reference: NCI:C12624
database_cross_reference: PSY:40040

Nerve Fibers, Myelinated
type: Class
subclass of: Neurons
subclass of: Nerve Fibers
PMOID: PMO:00000778
Subclass_of: Nerve Fibers
Subclass_of: Neurons
Synonym: Fiber, Myelinated Nerve
Synonym: Fibers, Myelinated Nerve
Synonym: Myelinated Nerve Fiber
Synonym: Myelinated Nerve Fibers
Synonym: Myelinated nerve fiber
Synonym: Myelinated nerve fiber structure
Synonym: Myelinated nerve fiber structure (body structure)
Synonym: Myelinated nerve fiber, NOS
Synonym: Myelinated nerve fibre
Synonym: Myelinated nerve fibre structure
Tree Number: T2.23.6.5
Tree Number: T2.23.7
database_cross_reference: CHV:0000008599
database_cross_reference: FMA:5915
database_cross_reference: MSH:D009413
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12627
database_cross_reference: SNM:T-X0340
database_cross_reference: SNMI:T-A0340
database_cross_reference: SNOMEDCT_US:54115001
database_cross_reference: UWDA:5915

Nerve Fibers, Unmyelinated
type: Class
subclass of: Nerve Fibers
PMOID: PMO:00000779
Subclass_of: Nerve Fibers
Synonym: Nerve Fiber, Unmyelinated
Synonym: Non myelinated nerve fiber
Synonym: Non myelinated nerve fiber (body structure)
Synonym: Non myelinated nerve fiber, NOS
Synonym: Non myelinated nerve fibre
Synonym: Non-myelinated nerve fiber
Synonym: Unmyelinated Nerve Fiber
Synonym: Unmyelinated Nerve Fibers
Synonym: Unmyelinated nerve fiber
Tree Number: T2.23.6.6
database_cross_reference: FMA:5916
database_cross_reference: MSH:D036421
database_cross_reference: NCI:C33835
database_cross_reference: SNM:T-X0350
database_cross_reference: SNMI:T-A0350
database_cross_reference: SNOMEDCT_US:46920005
database_cross_reference: UWDA:5916

Neurons, Afferent
type: Class
subclass of: Neurons
PMOID: PMO:00000780
Subclass_of: Neurons
Synonym: Afferent Neuron
Synonym: Afferent Neurons
Synonym: Afferent neuron
Synonym: Neuron, Afferent
Synonym: Sensory Cell Afferent Neuron
Synonym: Sensory Neuron
Synonym: Sensory Neurons
Synonym: Sensory neuron
Synonym: afferent neuron
Synonym: afferent neurons
Tree Number: T2.23.9
database_cross_reference: AOD:0000017714
database_cross_reference: CHV:0000008659
database_cross_reference: FMA:84649
database_cross_reference: FMA:87653
database_cross_reference: MSH:D009475
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12628
database_cross_reference: PSY:46610

Hair Cells, Auditory
type: Class
subclass of: Neurons, Afferent
PMOID: PMO:00000781
Subclass_of: Neurons, Afferent
Synonym: Auditory Hair Cell
Synonym: Auditory Hair Cells
Synonym: Auditory receptor
Synonym: Cell, Cochlear Hair
Synonym: Cells, Cochlear Hair
Synonym: Cochlear Hair Cell
Synonym: Cochlear Hair Cells
Synonym: Cochlear hair cell
Synonym: Corti Cell
Synonym: Corti cell
Tree Number: T2.23.9.1
database_cross_reference: AOD:0000017552
database_cross_reference: AOD:0000017628
database_cross_reference: AOD:0000027969
database_cross_reference: CHV:0000005763
database_cross_reference: CSP:0975-3295
database_cross_reference: FMA:62364
database_cross_reference: FMA:84660
database_cross_reference: LCH_NW:sh95005808
database_cross_reference: MSH:D006198
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12629
database_cross_reference: SNM:T-XY780
database_cross_reference: SNMI:T-AB890
database_cross_reference: SNOMEDCT_US:52148002

Hair Cells, Auditory, Inner
type: Class
subclass of: Hair Cells, Auditory
PMOID: PMO:00000782
Subclass_of: Hair Cells, Auditory
Synonym: Auditory Hair Cell, Inner
Synonym: Auditory Hair Cells, Inner
Synonym: Cell, Inner Hair
Synonym: Cells, Inner Hair
Synonym: Cochlear Inner Hair Cell
Synonym: Cochlear Inner Hair Cells
Synonym: Cochlear inner hair cell
Synonym: Hair Cell, Auditory, Inner
Synonym: Hair Cell, Inner
Synonym: Hair Cells, Inner
Tree Number: T2.23.9.1.1
database_cross_reference: CHV:0000005764
database_cross_reference: FMA:62365
database_cross_reference: MSH:D006199
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C32805
database_cross_reference: SNM:T-XY781
database_cross_reference: SNMI:T-AB891
database_cross_reference: SNOMEDCT_US:11520008

Hair Cells, Auditory, Outer
type: Class
subclass of: Hair Cells, Auditory
PMOID: PMO:00000783
Subclass_of: Hair Cells, Auditory
Synonym: Auditory Hair Cell, Outer
Synonym: Auditory Hair Cells, Outer
Synonym: Cochlear Outer Hair Cell
Synonym: Cochlear Outer Hair Cells
Synonym: Cochlear outer hair cell
Synonym: Hair Cell, Auditory, Outer
Synonym: Hair Cells, Auditory, Outer Inner
Synonym: Hair Cells, Outer
Synonym: Outer Auditory Hair Cell
Synonym: Outer Auditory Hair Cells
Tree Number: T2.23.9.1.2
database_cross_reference: FMA:62366
database_cross_reference: MSH:D018072
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C33233
database_cross_reference: SNM:T-XY782
database_cross_reference: SNMI:T-AB892
database_cross_reference: SNOMEDCT_US:43313002

Sensory Receptor Cells
type: Class
subclass of: Neurons, Afferent
PMOID: PMO:00000784
Subclass_of: Neurons, Afferent
Synonym: NEURAL RECEPT
Synonym: NEURORECEPT
Synonym: Neural Receptor
Synonym: Neural Receptors
Synonym: Neural receptors
Synonym: Neuron, Sensory
Synonym: Neurons, Sensory
Synonym: Neuroreceptor
Synonym: Neuroreceptors
Synonym: Peripheral ending of sensory neuron
Tree Number: T2.23.9.2
database_cross_reference: AOD:0000017550
database_cross_reference: AOD:0000027956
database_cross_reference: CHV:0000010627
database_cross_reference: CSP:4000-0324
database_cross_reference: FMA:84650
database_cross_reference: LCH:U006091
database_cross_reference: LCH_NW:sh88002450
database_cross_reference: MSH:D011984
database_cross_reference: MTH:NOCODE
database_cross_reference: PSY:33620
database_cross_reference: PSY:43300

Chemoreceptor Cells
type: Class
subclass of: Sensory Receptor Cells
PMOID: PMO:00000785
Subclass_of: Sensory Receptor Cells
Synonym: Cell, Chemoreceptive
Synonym: Cell, Chemoreceptor
Synonym: Cells, Chemoreceptive
Synonym: Cells, Chemoreceptor
Synonym: Chemoreceptive Cell
Synonym: Chemoreceptive Cells
Synonym: Chemoreceptor
Synonym: Chemoreceptor Cell
Synonym: Chemoreceptors
Synonym: chemoreceptor
Tree Number: T2.23.9.2.1
database_cross_reference: AOD:0000017551
database_cross_reference: CHV:0000002744
database_cross_reference: CSP:2681-9596
database_cross_reference: FMA:85604
database_cross_reference: LCH:U000939
database_cross_reference: LCH_NW:sh85023035
database_cross_reference: MSH:D002628
database_cross_reference: MTH:NOCODE
database_cross_reference: PSY:08570

Mechanoreceptors
type: Class
subclass of: Sensory Receptor Cells
PMOID: PMO:00000792
Subclass_of: Sensory Receptor Cells
Synonym: Auditory Receptor Cell
Synonym: Cell, Mechanoreceptor
Synonym: Cells, Mechanoreceptor
Synonym: MECHANORECEPT
Synonym: Mechanoreceptor
Synonym: Mechanoreceptor Cell
Synonym: Mechanoreceptor Cells
Synonym: mechanoreceptor
Synonym: mechanoreceptors
Tree Number: T2.23.9.2.2
database_cross_reference: CHV:0000007826
database_cross_reference: CSP:2681-9645
database_cross_reference: FMA:86587
database_cross_reference: LCH:U002850
database_cross_reference: LCH_NW:sh85082782
database_cross_reference: MSH:D008465
database_cross_reference: NCI:C13821
database_cross_reference: NCI:C33063
database_cross_reference: PSY:30250

Hair Cells, Vestibular
type: Class
subclass of: Neurons, Afferent
PMOID: PMO:00000797
Subclass_of: Neurons, Afferent
Synonym: Hair Cell, Vestibular
Synonym: Vestibular Hair Cell
Synonym: Vestibular Hair Cells
Synonym: Vestibular hair cell
Synonym: Vestibular sensory cell
Synonym: equilibrium hair cell
Tree Number: T2.23.9.3
database_cross_reference: AOD:0000017670
database_cross_reference: FMA:62351
database_cross_reference: MSH:D018069
database_cross_reference: NCI:C12632

Nociceptors
type: Class
subclass of: Sensory Receptor Cells
PMOID: PMO:00000798
Subclass_of: Sensory Receptor Cells
Synonym: NOCICEPT
Synonym: Neuron, Nociceptive
Synonym: Neurons, Nociceptive
Synonym: Nociceptive Neuron
Synonym: Nociceptive Neurons
Synonym: Nociceptor
Synonym: PAIN RECEPT
Synonym: Pain Receptor
Synonym: Pain Receptors
Synonym: RECEPT PAIN
Tree Number: T2.23.9.2.3
database_cross_reference: AOD:0000017655
database_cross_reference: AOD:0000017656
database_cross_reference: CHV:0000008753
database_cross_reference: CSP:5000-0033
database_cross_reference: LCH:U003255
database_cross_reference: LCH_NW:sh85092154
database_cross_reference: MSH:D009619
database_cross_reference: NCI:C13176
database_cross_reference: PSY:34080
database_cross_reference: PSY:36175

Photoreceptor Cells
type: Class
subclass of: Sensory Receptor Cells
subclass of: Retinal Neurons
PMOID: PMO:00000799
Subclass_of: Retinal Neurons
Subclass_of: Sensory Receptor Cells
Synonym: Cell, Photoreceptor
Synonym: Cells, Photoreceptor
Synonym: PHOTORECEPT CELLS
Synonym: Photoreceptor
Synonym: Photoreceptor Cell
Synonym: Photoreceptor cell
Synonym: Photoreceptors
Synonym: Photosensitive Cell
Synonym: photoreceptor
Synonym: photoreceptors
Tree Number: T2.23.9.2.4
Tree Number: T2.23.9.5.1
database_cross_reference: AOD:0000017585
database_cross_reference: AOD:0000027963
database_cross_reference: CHV:0000009688
database_cross_reference: FMA:85613
database_cross_reference: FMA:86740
database_cross_reference: LCH:U003651
database_cross_reference: LCH_NW:sh85101407
database_cross_reference: MSH:D010786
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12634
database_cross_reference: PSY:38430

Thermoreceptors
type: Class
subclass of: Sensory Receptor Cells
PMOID: PMO:00000808
Subclass_of: Sensory Receptor Cells
Synonym: THERMORECEPT
Synonym: Thermoreceptor
Synonym: receptors temperature
Synonym: temperature receptor
Synonym: thermoreceptor
Synonym: thermoreceptors
Tree Number: T2.23.9.2.5
database_cross_reference: AOD:0000017654
database_cross_reference: CHV:0000012167
database_cross_reference: CSP:2681-9760
database_cross_reference: LCH:U004649
database_cross_reference: LCH_NW:sh85134815
database_cross_reference: MSH:D013823
database_cross_reference: NCI:C13822
database_cross_reference: PSY:52840

Posterior Horn Cells
type: Class
subclass of: Neurons, Afferent
PMOID: PMO:00000809
Subclass_of: Neurons, Afferent
Synonym: Cell, Dorsal Horn
Synonym: Cell, Posterior Horn
Synonym: Cells, Dorsal Horn
Synonym: Cells, Posterior Horn
Synonym: Dorsal Horn Cell
Synonym: Dorsal Horn Cells
Synonym: Dorsal Horn Neuron
Synonym: Dorsal Horn Neurons
Synonym: Neuron, Dorsal Horn
Synonym: Neuron, Posterior Horn
Tree Number: T2.23.9.4
database_cross_reference: MSH:D020671
database_cross_reference: NCI:C12640

Substantia Gelatinosa
type: Class
subclass of: Posterior Horn Cells
PMOID: PMO:00000810
Subclass_of: Posterior Horn Cells
Synonym: Gelatinosa, Substantia
Synonym: Gelatinosas, Substantia
Synonym: Gelatinous substance of Rolando
Synonym: Gelatinous substance of posterior horn of spinal cord
Synonym: II
Synonym: Lamina 2
Synonym: Lamina II
Synonym: Lamina spinalis II
Synonym: Rexed's lamina II
Synonym: Rolando Substantia Gelatinosa
Tree Number: T2.23.9.4.1
database_cross_reference: FMA:74019
database_cross_reference: MSH:D013376
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12641
database_cross_reference: NEU:1635
database_cross_reference: RCD:Xa1PQ
database_cross_reference: SNM:T-X7432
database_cross_reference: SNMI:T-A7032
database_cross_reference: SNOMEDCT_US:280409008
database_cross_reference: SNOMEDCT_US:33138000

Retinal Neurons
type: Class
subclass of: Neurons, Afferent
PMOID: PMO:00000811
Subclass_of: Neurons, Afferent
Synonym: Neuron, Retinal
Synonym: Neurons, Retinal
Synonym: Retinal Neuron
Tree Number: T2.23.9.5
database_cross_reference: MSH:D055351

Retinal Ganglion Cells
type: Class
subclass of: Retinal Neurons
PMOID: PMO:00000812
Subclass_of: Retinal Neurons
Synonym: Cell, Retinal Ganglion
Synonym: Cells, Retinal Ganglion
Synonym: Ganglion Cell, Retinal
Synonym: Ganglion Cells (Retina)
Synonym: Ganglion Cells, Retinal
Synonym: Ganglion cell of retina
Synonym: Retinal Ganglion Cell
Synonym: Retinal ganglion cell
Synonym: Retinal ganglion cells
Synonym: retinal ganglion
Tree Number: T2.23.9.5.2
database_cross_reference: CHV:0000010799
database_cross_reference: CSP:1112-0001
database_cross_reference: FMA:67765
database_cross_reference: LCH:U004108
database_cross_reference: LCH_NW:sh85113334
database_cross_reference: MSH:D012165
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12642
database_cross_reference: PSY:20615
database_cross_reference: PSY:44440

Retinal Horizontal Cells
type: Class
subclass of: Retinal Neurons
PMOID: PMO:00000813
Subclass_of: Retinal Neurons
Synonym: Cell, Retinal Horizontal
Synonym: Cells, Retinal Horizontal
Synonym: Horizontal Cell, Retinal
Synonym: Horizontal Cells, Retinal
Synonym: Retinal Horizontal Cell
Tree Number: T2.23.9.5.5
database_cross_reference: MSH:D051248

Neurons, Efferent
type: Class
subclass of: Neurons
PMOID: PMO:00000814
Subclass_of: Neurons
Synonym: Efferent Nerve
Synonym: Efferent Neuron
Synonym: Efferent Neurons
Synonym: Motoneuron
Synonym: Motor Neurons
Synonym: Neuron, Efferent
Synonym: efferent nerve
Synonym: efferent neuron
Tree Number: T2.23.10
database_cross_reference: AOD:0000017717
database_cross_reference: CSP:2045-5033
database_cross_reference: MSH:D009476
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12643
database_cross_reference: NCI:C12644

Motor Neurons
type: Class
subclass of: Neurons, Efferent
PMOID: PMO:00000815
Subclass_of: Neurons, Efferent
Synonym: Motoneuron
Synonym: Motoneurons
Synonym: Motor Neuron
Synonym: Motor neuron
Synonym: Motor neuron (cell)
Synonym: Motor neurons
Synonym: Neuron, Motor
Synonym: Neurons, Motor
Synonym: motoneuron
Synonym: motoneurons
Tree Number: T2.23.10.1
database_cross_reference: AOD:0000017718
database_cross_reference: AOD:0000017719
database_cross_reference: AOD:0000028008
database_cross_reference: CHV:0000008277
database_cross_reference: CSP:2057-4197
database_cross_reference: FMA:83617
database_cross_reference: LCH:U003033
database_cross_reference: LCH_NW:sh85087586
database_cross_reference: MSH:D009046
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12644
database_cross_reference: PSY:32290
database_cross_reference: SNMI:T-A0390
database_cross_reference: SNOMEDCT_US:31513005

Anterior Horn Cells
type: Class
subclass of: Motor Neurons
PMOID: PMO:00000816
Subclass_of: Motor Neurons
Synonym: Anterior Horn Cell
Synonym: Anterior Horn Neuron
Synonym: Anterior Horn Neurons
Synonym: Cell, Anterior Horn
Synonym: Cell, Ventral Horn
Synonym: Cells, Anterior Horn
Synonym: Cells, Ventral Horn
Synonym: Neuron, Anterior Horn
Synonym: Neuron, Ventral Horn
Synonym: Neurons, Anterior Horn
Tree Number: T2.23.10.1.1
database_cross_reference: CHV:0000001237
database_cross_reference: MSH:D000870
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12645

Motor Neurons, Gamma
type: Class
subclass of: Motor Neurons
PMOID: PMO:00000817
Subclass_of: Motor Neurons
Synonym: Fusimotor Neuron
Synonym: Fusimotor Neurons
Synonym: Gamma Motor Neuron
Synonym: Gamma Motor Neurons
Synonym: Gamma Motorneuron
Synonym: Gamma Motorneurons
Synonym: Gamma motor neuron
Synonym: Gamma-Efferent Motor Neuron
Synonym: Gamma-Efferent Motor Neurons
Synonym: Motor Neuron, Gamma
Tree Number: T2.23.10.1.2
database_cross_reference: FMA:83660
database_cross_reference: MSH:D009047
database_cross_reference: NCI:C12646

Purkinje Cells
type: Class
subclass of: Neurons
PMOID: PMO:00000818
Subclass_of: Neurons
Synonym: Cell, Purkinje
Synonym: Cell, Purkyne
Synonym: Cells, Purkinje
Synonym: Cells, Purkyne
Synonym: Cerebellar Purkinje Cell
Synonym: Neuron, Purkinje
Synonym: Neurons, Purkinje
Synonym: Purkinje Cell
Synonym: Purkinje Neuron
Synonym: Purkinje Neurons
Tree Number: T2.23.12
database_cross_reference: AOD:0000017744
database_cross_reference: AOD:0000028024
database_cross_reference: CHV:0000010418
database_cross_reference: CSP:0480-1109
database_cross_reference: FMA:67969
database_cross_reference: LCH:U003956
database_cross_reference: LCH_NW:sh85109202
database_cross_reference: LNC:LP17260-8
database_cross_reference: MSH:D011689
database_cross_reference: NCI:C12651
database_cross_reference: PSY:42385
database_cross_reference: SNM:T-X0300
database_cross_reference: SNMI:T-A0300
database_cross_reference: SNOMEDCT_US:83626009

Pyramidal Cells
type: Class
subclass of: Neurons
PMOID: PMO:00000819
Subclass_of: Neurons
Synonym: Cell, Pyramidal
Synonym: Cells, Pyramidal
Synonym: Neuron, Pyramidal
Synonym: Neurons, Pyramidal
Synonym: Pyramidal Cell
Synonym: Pyramidal Neuron
Synonym: Pyramidal Neurons
Synonym: Pyramidal cell
Synonym: Pyramidal cell (body structure)
Synonym: Pyramidal cell (cell)
Tree Number: T2.23.15
database_cross_reference: CSP:0480-5018
database_cross_reference: MSH:D017966
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12652
database_cross_reference: SNM:T-X0221
database_cross_reference: SNMI:T-A0221
database_cross_reference: SNOMEDCT_US:17522008

Place Cells
type: Class
subclass of: Pyramidal Cells
PMOID: PMO:00000820
Subclass_of: Pyramidal Cells
Synonym: Cell, Hippocampal Place
Synonym: Cell, Place
Synonym: Cells, Hippocampal Place
Synonym: Cells, Place
Synonym: Hippocampal Place Cell
Synonym: Hippocampal Place Cells
Synonym: Place Cell
Synonym: Place Cell, Hippocampal
Synonym: Place Cells, Hippocampal
Tree Number: T2.23.15.1
database_cross_reference: MSH:D000071037

Nitrergic Neurons
type: Class
subclass of: Neurons
PMOID: PMO:00000821
Subclass_of: Neurons
Synonym: Neuron, Nitrergic
Synonym: Neuron, Nitroxidergic
Synonym: Neurons, Nitrergic
Synonym: Neurons, Nitroxidergic
Synonym: Nitrergic Neuron
Synonym: Nitrergic neuron
Synonym: Nitroxidergic Neuron
Synonym: Nitroxidergic Neurons
Tree Number: T2.23.17
database_cross_reference: FMA:84792
database_cross_reference: MSH:D026602
database_cross_reference: NCI:C12647

Mirror Neurons
type: Class
subclass of: Neurons
PMOID: PMO:00000822
Subclass_of: Neurons
Synonym: Mirror Neuron
Synonym: Mirror neurons
Synonym: Neuron, Mirror
Synonym: Neurons, Mirror
Tree Number: T2.23.18
database_cross_reference: LCH_NW:sh2006009040
database_cross_reference: MSH:D059167

Dopaminergic Neurons
type: Class
subclass of: Neurons
PMOID: PMO:00000823
Subclass_of: Neurons
Synonym: Dopamine Neuron
Synonym: Dopamine Neurons
Synonym: Dopaminergic Cell
Synonym: Dopaminergic Neuron
Synonym: Dopaminergic cell
Synonym: Dopaminergic cells
Synonym: Dopaminergic cells set
Synonym: Dopaminergic neuron
Synonym: Dopaminergic neurons
Synonym: Neuron, Dopamine
Tree Number: T2.23.19
database_cross_reference: AOD:0000017749
database_cross_reference: AOD:0000028025
database_cross_reference: CHV:0000049346
database_cross_reference: FMA:78545
database_cross_reference: FMA:84787
database_cross_reference: LCH_NW:sh00000066
database_cross_reference: MSH:D059290
database_cross_reference: NCI:C26454

Serotonergic Neurons
type: Class
subclass of: Neurons
PMOID: PMO:00000824
Subclass_of: Neurons
Synonym: Neuron, Serotonergic
Synonym: Neuron, Serotoninergic
Synonym: Neurons, Serotonergic
Synonym: Neurons, Serotoninergic
Synonym: Serotonergic Neuron
Synonym: Serotoninergic Neuron
Synonym: Serotoninergic Neurons
Tree Number: T2.23.20
database_cross_reference: MSH:D059326

Cholinergic Neurons
type: Class
subclass of: Neurons
PMOID: PMO:00000825
Subclass_of: Neurons
Synonym: Cholinergic Neuron
Synonym: Cholinergic neuron
Synonym: Neuron, Cholinergic
Synonym: Neurons, Cholinergic
Tree Number: T2.23.21
database_cross_reference: FMA:84796
database_cross_reference: MSH:D059329

GABAergic Neurons
type: Class
subclass of: Neurons
PMOID: PMO:00000826
Subclass_of: Neurons
Synonym: Cell, GABA
Synonym: Cells, GABA
Synonym: GABA Cell
Synonym: GABA Cells
Synonym: GABA Neuron
Synonym: GABA Neurons
Synonym: GABA-ergic neuron
Synonym: GABAergic Neuron
Synonym: GABAergic neuron
Synonym: Neuron, GABA
Tree Number: T2.23.22
database_cross_reference: AOD:0000017747
database_cross_reference: FMA:84788
database_cross_reference: MSH:D059330

Adrenergic Neurons
type: Class
subclass of: Neurons
PMOID: PMO:00000827
Subclass_of: Neurons
Synonym: Adrenergic Neuron
Synonym: Neuron, Adrenergic
Synonym: Neurons, Adrenergic
Tree Number: T2.23.23
database_cross_reference: MSH:D059331

Oxyphil Cells
type: Class
subclass of: Cell
PMOID: PMO:00000828
Subclass_of: Cell
Synonym: Askenazy Cells
Synonym: Cells, Oxyphil
Synonym: Oncocyte
Synonym: Oncocytes
Synonym: Oxyphil Cell
Synonym: Oxyphil cell
Synonym: Oxyphilic Cell
Synonym: oncocyte
Synonym: oncocytes
Synonym: oxyphil cell
Tree Number: T2.24
database_cross_reference: CHV:0000053430
database_cross_reference: FMA:67606
database_cross_reference: FMA:86658
database_cross_reference: MSH:D024862
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12654
database_cross_reference: UWDA:67606

Pancreatic Stellate Cells
type: Class
subclass of: Cell
PMOID: PMO:00000829
Subclass_of: Cell
Synonym: Cell, Pancreatic Stellate
Synonym: Cells, Pancreatic Stellate
Synonym: PSC
Synonym: PSCs
Synonym: PaSC
Synonym: PaSCs
Synonym: Pancreatic Stellate Cell
Synonym: Stellate Cell, Pancreatic
Synonym: Stellate Cells, Pancreatic
Tree Number: T2.25
database_cross_reference: MSH:D058954
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C107531

Phagocytes
type: Class
subclass of: Cell
PMOID: PMO:00000830
Subclass_of: Cell
Synonym: Cell, Phagocytic
Synonym: Cells, Phagocytic
Synonym: Phagocyte
Synonym: Phagocyte, NOS
Synonym: Phagocytic Cell
Synonym: Phagocytic Cells
Synonym: Phagocytic cell
Synonym: Phagocytic cell (body structure)
Synonym: Phagocytic cell (cell)
Synonym: Phagocytic cell, NOS
Tree Number: T2.27
database_cross_reference: AOD:0000017482
database_cross_reference: CHV:0000009567
database_cross_reference: CSP:0605-5617
database_cross_reference: FMA:83806
database_cross_reference: LCH:U003589
database_cross_reference: LCH_NW:sh85100548
database_cross_reference: MSH:D010586
database_cross_reference: NCI:C12657
database_cross_reference: NCI_NCI-GLOSS:CDR0000043979
database_cross_reference: SNM:M-69510
database_cross_reference: SNMI:M-62400
database_cross_reference: SNOMEDCT_US:73568005

Plant Cells
type: Class
subclass of: Cell
PMOID: PMO:00000831
Subclass_of: Cell
Tree Number: T2.28

Prokaryotic Cells
type: Class
subclass of: Cell
PMOID: PMO:00000832
Subclass_of: Cell
Tree Number: T2.29

Protoplasts
type: Class
subclass of: Cell
PMOID: PMO:00000833
Subclass_of: Cell
Synonym: Protoplast
Synonym: protoplast
Tree Number: T2.30
database_cross_reference: CHV:0000010263
database_cross_reference: CSP:0605-5721
database_cross_reference: GO:GO:0005622
database_cross_reference: GO:GO:0044464
database_cross_reference: LCH:U003886
database_cross_reference: LCH_NW:sh85107805
database_cross_reference: MSH:D011523
database_cross_reference: NCI:C12659

Reed-Sternberg Cells
type: Class
subclass of: Cell
PMOID: PMO:00000834
Subclass_of: Cell
Synonym: Cells, Reed-Sternberg
Synonym: Cells, Sternberg-Reed
Synonym: R-S Cell
Synonym: Reed Sternberg Cells
Synonym: Reed-Sternberg Cell
Synonym: Reed-Sternberg cell
Synonym: Reed-Sternberg cell (body structure)
Synonym: Reed-Sternberg cell (cell)
Synonym: Sternberg Reed Cells
Synonym: Sternberg-Reed Cells
Tree Number: T2.31
database_cross_reference: CHV:0000015454
database_cross_reference: MSH:D016539
database_cross_reference: NCI:C12660
database_cross_reference: NCI_NCI-GLOSS:CDR0000046557
database_cross_reference: SNMI:M-64550
database_cross_reference: SNOMEDCT_US:32915009

Spheroplasts
type: Class
subclass of: Cell
PMOID: PMO:00000835
Subclass_of: Cell
Synonym: Spheroplast
Synonym: spheroplast
Synonym: spheroplasts
Tree Number: T2.32
database_cross_reference: CHV:0000011599
database_cross_reference: CSP:0605-5721
database_cross_reference: LCH:U004424
database_cross_reference: LCH_NW:sh85126602
database_cross_reference: MSH:D013104
database_cross_reference: NCI:C12661

Spores
type: Class
subclass of: Cell
PMOID: PMO:00000836
Subclass_of: Cell
Tree Number: T2.33

Spores, Bacterial
type: Class
subclass of: Spores
PMOID: PMO:00000837
Subclass_of: Spores
Tree Number: T2.33.1

Spores, Fungal
type: Class
subclass of: Spores
PMOID: PMO:00000838
Subclass_of: Spores
Tree Number: T2.33.2

Spores, Protozoan
type: Class
subclass of: Spores
PMOID: PMO:00000839
Subclass_of: Spores
Tree Number: T2.33.3

Oocysts
type: Class
subclass of: Spores, Protozoan
PMOID: PMO:00000840
Subclass_of: Spores, Protozoan
Tree Number: T2.33.3.1

Sporozoites
type: Class
subclass of: Oocysts
PMOID: PMO:00000841
Subclass_of: Oocysts
Tree Number: T2.33.3.1.1

Schizonts
type: Class
subclass of: Spores, Protozoan
PMOID: PMO:00000842
Subclass_of: Spores, Protozoan
Tree Number: T2.33.3.2

Merozoites
type: Class
subclass of: Schizonts
PMOID: PMO:00000843
Subclass_of: Schizonts
Tree Number: T2.33.3.2.1

Trophozoites
type: Class
subclass of: Spores, Protozoan
PMOID: PMO:00000844
Subclass_of: Spores, Protozoan
Tree Number: T2.33.3.3

Stem Cells
type: Class
subclass of: Cell
PMOID: PMO:00000845
Subclass_of: Cell
Synonym: Cell, Mother
Synonym: Cell, Progenitor
Synonym: Cell, Stem
Synonym: Cells, Mother
Synonym: Cells, Progenitor
Synonym: Cells, Stem
Synonym: Mother Cell
Synonym: Mother Cells
Synonym: Mother cell
Synonym: Progenitor Cell
Tree Number: T2.34
database_cross_reference: AOD:0000016827
database_cross_reference: CHV:0000011716
database_cross_reference: CSP:4009-0065
database_cross_reference: FMA:63368
database_cross_reference: LCH:U004471
database_cross_reference: LCH_NW:sh85127923
database_cross_reference: MEDLINEPLUS:1395
database_cross_reference: MSH:D013234
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12662
database_cross_reference: NCI_NCI-GLOSS:CDR0000046598
database_cross_reference: RCD:X80Vi
database_cross_reference: SNM:T-06011
database_cross_reference: SNMI:T-C0106
database_cross_reference: SNOMEDCT_US:419758009
database_cross_reference: SNOMEDCT_US:50312002
database_cross_reference: UWDA:63368

Oogonial Stem Cells
type: Class
subclass of: Stem Cells
PMOID: PMO:00000846
Subclass_of: Stem Cells
Synonym: Female Germline Stem Cells
Synonym: Oogonial Stem Cell
Synonym: Ovarian Germline Stem Cells
Synonym: Stem Cell, Oogonial
Synonym: Stem Cells, Oogonial
Tree Number: T2.34.1
database_cross_reference: MSH:D000072977

Peripheral Blood Stem Cells
type: Class
subclass of: Hematopoietic Stem Cells
PMOID: PMO:00000847
Subclass_of: Hematopoietic Stem Cells
Synonym: PBSC
Synonym: Peripheral Blood Stem Cell
Synonym: Peripheral Stem Cell
Synonym: Peripheral Stem Cells
Synonym: Peripheral blood stem cell
Synonym: Peripheral blood stem cell (cell)
Synonym: Stem Cell, Peripheral
Synonym: Stem Cells, Peripheral
Synonym: cell peripheral stem
Synonym: peripheral stem cell
Tree Number: T2.34.2.1
database_cross_reference: CHV:0000042696
database_cross_reference: FMA:86711
database_cross_reference: MSH:D000072916
database_cross_reference: NCI:C12946
database_cross_reference: NCI_NCI-GLOSS:CDR0000045828
database_cross_reference: SNOMEDCT_US:419583006

Neoplastic Stem Cells
type: Class
subclass of: Stem Cells
PMOID: PMO:00000848
Subclass_of: Stem Cells
Synonym: Cell, Neoplastic Stem
Synonym: Cell, Tumor Initiating
Synonym: Cell, Tumor Stem
Synonym: Cells, Neoplastic Stem
Synonym: Cells, Tumor Initiating
Synonym: Cells, Tumor Stem
Synonym: Initiating Cell, Tumor
Synonym: Initiating Cells, Tumor
Synonym: NEOPL STEM CELLS
Synonym: Neoplastic Stem Cell
Tree Number: T2.34.3
database_cross_reference: CHV:0000012660
database_cross_reference: MSH:D014411

Myoblasts
type: Class
subclass of: Stem Cells
PMOID: PMO:00000849
Subclass_of: Stem Cells
Synonym: Embryonic Muscle Cell
Synonym: Embryonic Muscle Cells
Synonym: Muscle Cell, Embryonic
Synonym: Muscle Cell, Precursor
Synonym: Muscle Cells, Embryonic
Synonym: Muscle Cells, Precursor
Synonym: Myoblast
Synonym: Precursor Muscle Cell
Synonym: Precursor Muscle Cells
Synonym: myoblast
Tree Number: T2.34.4
database_cross_reference: CHV:0000041657
database_cross_reference: CSP:1975-6415
database_cross_reference: FMA:70335
database_cross_reference: LCH_NW:sh90003813
database_cross_reference: MSH:D032446
database_cross_reference: NCI:C33151
database_cross_reference: UWDA:70335

Myoblasts, Smooth Muscle
type: Class
subclass of: Myoblasts
PMOID: PMO:00000850
Subclass_of: Myoblasts
Synonym: Myoblast, Smooth Muscle
Synonym: Smooth Muscle Myoblast
Synonym: Smooth Muscle Myoblasts
Synonym: Smooth muscle myoblast
Tree Number: T2.34.4.2
database_cross_reference: FMA:84798
database_cross_reference: MSH:D032390

Myoblasts, Skeletal
type: Class
subclass of: Myoblasts
PMOID: PMO:00000851
Subclass_of: Myoblasts
Synonym: Myoblast, Skeletal
Synonym: Skeletal Myoblast
Synonym: Skeletal Myoblasts
Synonym: Skeletal myoblast
Synonym: myoblast skeletal
Synonym: skeletal myoblast
Tree Number: T2.34.4.3
database_cross_reference: CHV:0000054913
database_cross_reference: FMA:84799
database_cross_reference: MSH:D032448

Satellite Cells, Skeletal Muscle
type: Class
subclass of: Myoblasts, Skeletal
PMOID: PMO:00000852
Subclass_of: Myoblasts, Skeletal
Synonym: Cell, Myogenic Satellite
Synonym: Cells, Myogenic Satellite
Synonym: Myogenic Satellite Cell
Synonym: Myogenic Satellite Cells
Synonym: Satellite Cell, Myogenic
Synonym: Satellite Cells, Myogenic
Synonym: Skeletal Muscle Satellite Cells
Tree Number: T2.34.4.3.1
database_cross_reference: MSH:D032496

Totipotent Stem Cells
type: Class
subclass of: Stem Cells
PMOID: PMO:00000853
Subclass_of: Stem Cells
Synonym: Cell, Totipotent Stem
Synonym: Cells, Totipotent Stem
Synonym: Stem Cell, Totipotent
Synonym: Stem Cells, Totipotent
Synonym: Totipotent Stem Cell
Synonym: Totipotent stem cell
Synonym: Totipotential stem cell
Synonym: totipotent stem cell
Tree Number: T2.34.5
database_cross_reference: CSP:4001-0045
database_cross_reference: CSP:4009-0065
database_cross_reference: FMA:84790
database_cross_reference: MSH:D039901
database_cross_reference: NCI:C12978

Multipotent Stem Cells
type: Class
subclass of: Stem Cells
PMOID: PMO:00000854
Subclass_of: Stem Cells
Synonym: Multipotent Stem Cell
Synonym: Multipotent cell
Synonym: Multipotent stem cell
Synonym: Multipotent stem cells
Synonym: Multipotential stem cell
Synonym: Stem Cell, Multipotent
Synonym: Stem Cells, Multipotent
Synonym: multipotent cell
Tree Number: T2.34.6
database_cross_reference: CSP:4009-0066
database_cross_reference: FMA:84789
database_cross_reference: LCH_NW:sh2010012755
database_cross_reference: MSH:D039902
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C43419

Pluripotent Stem Cells
type: Class
subclass of: Stem Cells
PMOID: PMO:00000855
Subclass_of: Stem Cells
Synonym: Pluripotent Stem Cell
Synonym: Pluripotent stem cell
Synonym: Pluripotential stem cell
Synonym: Stem Cell, Pluripotent
Synonym: Stem Cells, Pluripotent
Synonym: pluripotent stem cell
Synonym: pluripotent stem cells
Tree Number: T2.34.7
database_cross_reference: CHV:0000051524
database_cross_reference: CSP:4009-0066
database_cross_reference: FMA:70570
database_cross_reference: MSH:D039904
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C12977
database_cross_reference: NCI_NCI-GLOSS:CDR0000044797
database_cross_reference: UWDA:70570

Embryonic Stem Cells
type: Class
subclass of: Pluripotent Stem Cells
PMOID: PMO:00000856
Subclass_of: Pluripotent Stem Cells
Synonym: Cell, Embryonic Stem
Synonym: Cells, Embryonic Stem
Synonym: ES cell
Synonym: Embryonic Stem Cell
Synonym: Embryonic stem cell
Synonym: Embryonic stem cell (cell)
Synonym: Embryonic stem cells
Synonym: Stem Cell, Embryonic
Synonym: Stem Cells, Embryonic
Synonym: cell embryonic stem
Tree Number: T2.34.7.1
database_cross_reference: CHV:0000041562
database_cross_reference: CSP:4001-0045
database_cross_reference: FMA:82841
database_cross_reference: LCH_NW:sh92005532
database_cross_reference: MSH:D053595
database_cross_reference: NCI:C12935
database_cross_reference: SNOMEDCT_US:419965008

Human Embryonic Stem Cells
type: Class
subclass of: Embryonic Stem Cells
PMOID: PMO:00000857
Subclass_of: Embryonic Stem Cells
Synonym: Cells, Human Embryonic Stem
Synonym: Human Embryonic Stem Cell
Synonym: Stem Cells, Human Embryonic
Synonym: cells embryonic human stem
Synonym: hESCs
Synonym: human embryonic stem cell
Tree Number: T2.34.7.1.1
database_cross_reference: CHV:0000055767
database_cross_reference: CSP:5002-0013
database_cross_reference: MSH:D000066449

Mouse Embryonic Stem Cells
type: Class
subclass of: Embryonic Stem Cells
PMOID: PMO:00000858
Subclass_of: Embryonic Stem Cells
Tree Number: T2.34.7.1.2

Embryoid Bodies
type: Class
subclass of: Embryonic Stem Cells
PMOID: PMO:00000859
Subclass_of: Embryonic Stem Cells
Synonym: Bodies, Embryoid
Synonym: Body, Embryoid
Synonym: Embryoid Body
Tree Number: T2.34.7.1.6
database_cross_reference: MSH:D058732

Induced Pluripotent Stem Cells
type: Class
subclass of: Pluripotent Stem Cells
subclass of: Adult Stem Cells
PMOID: PMO:00000860
Subclass_of: Adult Stem Cells
Subclass_of: Pluripotent Stem Cells
Synonym: Cell, IPS
Synonym: Cells, IPS
Synonym: IPS Cell
Synonym: IPS Cells
Synonym: Induced Pluripotent Stem Cell
Synonym: iPSC
Tree Number: T2.34.7.2
Tree Number: T2.34.9.2
database_cross_reference: MSH:D057026
database_cross_reference: NCI:C124144

Fetal Stem Cells
type: Class
subclass of: Stem Cells
PMOID: PMO:00000861
Subclass_of: Stem Cells
Synonym: Cell, Fetal Stem
Synonym: Cells, Fetal Stem
Synonym: Fetal Stem Cell
Synonym: Stem Cell, Fetal
Synonym: Stem Cells, Fetal
Tree Number: T2.34.8
database_cross_reference: MSH:D053686

Adult Stem Cells
type: Class
subclass of: Stem Cells
PMOID: PMO:00000862
Subclass_of: Stem Cells
Synonym: 'Adult' stem cell
Synonym: Adult Somatic Stem Cells
Synonym: Adult Stem Cell
Synonym: Somatic Adult Stem Cells
Synonym: Somatic Stem Cell
Synonym: Somatic Stem Cells
Synonym: Somatic stem cell
Synonym: Somatic stem cell (cell)
Synonym: Stem Cell, Somatic
Synonym: Stem Cells, Adult
Tree Number: T2.34.9
database_cross_reference: CHV:0000055761
database_cross_reference: CSP:4009-0065
database_cross_reference: MSH:D053687
database_cross_reference: NCI:C43420
database_cross_reference: SNOMEDCT_US:417904004

Adult Germline Stem Cells
type: Class
subclass of: Adult Stem Cells
PMOID: PMO:00000863
Subclass_of: Adult Stem Cells
Synonym: Germline Adult Stem Cells
Synonym: Progenitor Cells, Spermatogonial
Synonym: Spermatogonial Progenitor Cell
Synonym: Spermatogonial Progenitor Cells
Tree Number: T2.34.9.1
database_cross_reference: MSH:D000072956

Neural Stem Cells
type: Class
subclass of: Stem Cells
PMOID: PMO:00000864
Subclass_of: Stem Cells
Synonym: Cell, Neural Stem
Synonym: Cells, Neural Stem
Synonym: Neural Stem Cell
Synonym: Neural stem cell
Synonym: Neural stem cells
Synonym: Stem Cell, Neural
Synonym: Stem Cells, Neural
Synonym: cells nerve stem
Synonym: nerve stem cell
Tree Number: T2.34.10
database_cross_reference: CHV:0000054748
database_cross_reference: CSP:5000-0038
database_cross_reference: FMA:86684
database_cross_reference: LCH_NW:sh2003001310
database_cross_reference: MSH:D058953
database_cross_reference: NCI:C12985

Side-Population Cells
type: Class
subclass of: Stem Cells
PMOID: PMO:00000865
Subclass_of: Stem Cells
Synonym: Cell, Side-Population
Synonym: Cells, Side-Population
Synonym: Side Population Cells
Synonym: Side-Population Cell
Tree Number: T2.34.11
database_cross_reference: MSH:D058985

Biochemical Pathway
type: Class
subclass of: Thing
definition: A series of biochemical reactions which occurs in a known sequence and can result in all or part of the initiation, progression or completion of a biological process or function.
PMOID: PMO:00014365
Subclass_of: owl:Thing
Synonym: Metabolic Network
Synonym: Metabolic Networks
Synonym: Network, Metabolic
Synonym: Networks, Metabolic
Tree Number: T4
database_cross_reference: MSH:D053858
database_cross_reference: NCI:C20633

Cell Differentiation or Development Pathway
type: Class
subclass of: Biochemical Pathway
definition: A sequence of biological or biochemical events that are involved in embryological or cellular development.
PMOID: PMO:00014366
Subclass_of: Biochemical Pathway
Tree Number: T4.1
database_cross_reference: NCI:C39704

Agrin Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: The heparan sulfate proteoglycan agrin is well known as the key assembly factor of postsynaptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle. Signaling through muscle-specific proteins such as muscle specific kinase (MuSK) and or acetylcholine receptor (AchRs)/rapsyn, agrin can activate ubiquitously expressed Rac, Cdc42, and p21-activated kinase (PAK) that are involved in actin polymerization. Agrin also engages signaling pathways of several potent oncogenes (i.e., SFK, ErbB receptors, and cortactin). (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014367
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Agrin in Postsynaptic Differentiation
Tree Number: T4.1.1
database_cross_reference: NCI:C38975
database_cross_reference: NCI_BioC:C38975

ALK Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Heart formation is cued by a combination of positive and negative signals from surrounding tissues. Inhibitory signals that block heart formation in anterior paraxial mesoderm include Wnt family members expressed in dorsal neural tube and anti-BMPs expressed in the axial tissues (i.e., noggin in the notochord). Wnt signaling pathway, which is essential for setting up the entire body pattern during embryonic development, involves glycogen synthase kinase-3 (GSK3). In the absence of Wnt signaling, GSK3 is active and phosphorylates b-catenin resulting in its degradation by ubiquitin-mediated proteolysis. Activation of Wnt signaling inhibits GSK3, thereby preventing phosphorylation of b-catenin, which is then able to move to the nucleus. There it associates with members of the LEF-1/TCF family of transcription factors, which activate the transcription of genes like cyclin-D1, myc, and MMPs. The Wnt signaling pathway is blocked by a family of secreted proteins such as crescent and Dkk-1 sufficient for induction of heart formation in posterior mesoderm. BMP signaling can also be blocked by the BMP antagonists noggin and chordin, which are secreted from the notochord and cooperate with Wnts to prevent cardiogenesis. Receptors for BMPs, members of the transforming growth factor-beta (TGFb) superfamily, are persistently expressed during cardiac development, yet mice lacking type II or type IA BMP receptors die at gastrulation and cannot be used to assess potential later roles in creation of the heart. Activin receptor-like kinase 3 (ALK3) is specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. Cardiac muscle lacking ALK3 is specifically deficient in expressing TGFb2, an established paracrine mediator of cushion morphogenesis. In humans, congenital heart defects occur with a prevalence of at least 1% in newborns, and are even more common in death before term. Most frequent are de…
PMOID: PMO:00014368
Subclass_of: Cell Differentiation or Development Pathway
Synonym: ALK in cardiac myocytes
Tree Number: T4.1.2
database_cross_reference: NCI:C38982
database_cross_reference: NCI_BioC:C38982

Axon Guidance Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
PMOID: PMO:00014369
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Axon Guidance
Synonym: Axon Pathfinding
Synonym: Axon guidance
Synonym: Axonal Pathfinding
Synonym: Neural Guidance
Synonym: Neural Pathfinding
Synonym: Neurite Guidance
Synonym: Neuronal Guidance
Synonym: Neuronal Pathfinding
Synonym: Pathfinding, Axon
Tree Number: T4.1.3
database_cross_reference: CSP:2047-3461
database_cross_reference: GO:GO:0007411
database_cross_reference: MSH:D000071437
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91455
database_cross_reference: NCI_KEGG:C91455

Bone Remodeling Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Bone density and structure is maintained through a balance of bone resorption by osteoclasts and bone deposition by osteoblasts. The combination of simultaneous resorption and deposition creates continual remodeling of bone while excess osteoclast activity leads to an imbalance and a loss of bone density, causing osteoporosis. RANK (receptor activator of NF-kB ligand) is a receptor in the TNF receptor gene family that is involved in osteoclast differentiation. RANK-ligand, also called osteoprotegerin-ligand, binds to RANK, induces receptor dimerization, and activates downstream signaling. Osteoprotegerin is a decoy receptor for RANK-ligand that suppresses osteoclast activity and bone remodeling, helping to maintain balanced bone remodeling. RANK-ligand and osteoprotegerin are produced by osteoblasts and some factors regulate osteoclast activity indirectly through their action on the expression of these factors by osteoblasts. Binding of RANK-ligand to RANK activates signaling through TRAF-6. TRAF-6 induces several downstream signaling events, including activation of NF-kB, c-Fos and the kinase JNK1. Jnk-1 activation contributes to fos activation by RANK-ligand and may be involved in the modulation of RANK-ligand by other factors such as estrogen. Mice lacking the c-Fos gene have overly dense bone and decreased bone resorption due to reduced osteoclast differentiation, indicating that c-Fos is an important mediator of osteoclast differentiation. One of the results of c-Fos induction is transcriptional activation of interferon-beta. Interferon-beta binds to its receptor on neighboring osteoclast precursor cells to block RANK-ligand signaling and down-regulate c-Fos expression, inhibiting further osteoclast differentiation. Mice lacking interferon-beta or the interferon-beta receptor lose bone due to uncontrolled osteoclast activity, demonstrating the importance of this mechanism in vivo. Interferon-beta signaling could be used as a mechanism to prevent osteoporosis an…
PMOID: PMO:00014370
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Bone Remodelling
Synonym: Bone Remodelling Pathway
Tree Number: T4.1.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39212
database_cross_reference: NCI_BioC:C39212

Calcineurin Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: The differentiation of keratinocytes constantly replenishes the upper layers of human skin we lose each day. One factor that contributes to terminal keratinocyte differentiation is increased levels of intracellular calcium. Adding calcium to the medium of cultured keratinocytes elevates intracellular calcium and triggers differentiation. Intracellular calcium levels are also increased in response to phospholipase C activation, producing IP3 and releasing calcium from stores in the ER. Intracellular calcium alters multiple signaling pathways, one of which is binding to calmodulin to activate the serine-threonine protein phosphatase calcineurin. Calcineurin dephosphorylates and activates the transcription factor NFAT and both calcineurin and NFAT are expressed in differentiating keratinocytes. Activated NFAT can regulate transcription through binding its own cognate DNA binding site. One marker of keratinocyte differentiation, the p21 gene, is activated by NFAT by a different mechanism, with NFAT activating the p21 promoter by acting as a coactivator for the transcription factors Sp1 and Sp3.Another protein activated by calcium that may be involved in keratinocyte differentiation is protein kinase C (PKC). One substrate of activated PKC is MARCKS (myristoylated alanine-rich kinase C substrate). Phosphorylation of MARCKS by PKC in intact keratinocytes is not induced during calcium-induced differentiation, but does increase when tested in vitro. PKC activity is increased by calcium during keratinocyte differentiation but PKC MARCKS phosphorylation is blocked by the formation of a complex between calmodulin and MARCKS. The immunosuppressants cyclosporin-A (CsA) and FK506 inhibit T cell activation through indirect inhibition of NFAT activation and have several side effects including changes in the skin, suggesting that calcineurin activity may play a role in normal skin physiology. CsA is used to treat psoriasis, a disease involving abnormal proliferation of skin cells. T…
PMOID: PMO:00014371
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Effects of calcineurin in Keratinocyte Differentiation
Tree Number: T4.1.5
database_cross_reference: NCI:C39010
database_cross_reference: NCI_BioC:C39010

Dorso-Ventral Axis Formation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
PMOID: PMO:00014372
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Dorso-ventral axis formation
Tree Number: T4.1.6
database_cross_reference: NCI:C91432
database_cross_reference: NCI_KEGG:C91432

Erythrocyte Differentiation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth factors. CFU-GEMM cells are a key intermediate in the differentiation of granulocytes, erythrocytes, monocytes and megakaryocytes. Erythropoietin (EPO) is a cytokine produced in the kidneys that, along with other cytokines, induces red blood cell (erythrocyte) differentiation in the bone marrow from CFU-GEMM cells. As the erythrocyte lineage progresses, cells lose their nuclei, and move out of the bone marrow into circulation. The ability of EPO to selectively induce red blood cell differentiation has allowed extensive therapeutic use of the recombinant form of this cytokine to treat anemias. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014373
Subclass_of: Cell Differentiation or Development Pathway
Tree Number: T4.1.7
database_cross_reference: NCI:C39073
database_cross_reference: NCI_BioC:C39073

Function of SLRP in Bone Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: SLRPs (Small leucine-rich proteoglycans) are extracellular molecules that bind to TGF-betas, collagens and other matrix molecules. In vitro, SLRPs were shown to regulate collagen fibrillogenesis, a process essential in development, tissue repair, and metastasis. The resilience and strength of bone is due to the orderly mineralization of a specialized extracellular matrix (ECM) composed of type I collagen (90%) and a host of non-collagenous proteins that are, in general, also found in other tissues. Biglycan (an SLRP encoded by the gene Bgn) is an ECM proteoglycan that is enriched in bone and other non-skeletal connective tissues. In vitro studies indicate that Bgn may function in connective tissue metabolism by binding to collagen fibrils and TGF-beta, and may promote neuronal survival. The effects of an individual SLRP deficiency are tissue specific and a variety of morphological phenotypes are the result of variations in level of expression of individual SLRPs in different tissues and synergisms between different SLRPs (and likely other macromolecules) in determining matrix structures. For example collagen structural phenotypes demonstrate a cooperative, sequential, timely orchestrated action of the SLRPs that altogether shape the architecture and mechanical properties of the collagen matrix. Disruption of the bgn gene results in reduced skeletal growth and bone mass leading to generalized osteopenia, particularly in older animals. In addition, other SLRP-deficient mice develop a wide array of diseases (osteoporosis, osteoarthritis, muscular dystrophy, Ehlers-Danlos syndrome, and corneal diseases), most of them resulting primarily from an abnormal collagen fibrillogenesis. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014374
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Function of SLRP in Bone: An Integrated View
Synonym: Small Leucine-Rich Proteoglycans in Bone Pathway
Tree Number: T4.1.8
database_cross_reference: NCI:C91301
database_cross_reference: NCI_BioC:C91301

Hematopoiesis Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: The process of hematopoiesis is regulated by various cytokines. The combination of cytokines stimulates the proliferation and/or differentiation of the various hematopoietic cell types. Bone marrow stromal cells are the major source of hematopoietic cytokines in the non-infectious state. In the presence of infection, cytokines produced by activated macrophages and TH cells induce hematopoietic activity. The induction by cytokines results in rapid expansion of the population of white blood cells to fight infection. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014375
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Regulation of hematopoiesis by cytokines
Tree Number: T4.1.9
database_cross_reference: NCI:C39240
database_cross_reference: NCI_BioC:C39240

HOP Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Homeodomain transcription factors comprise a large family of DNA binding factors that regulate transcription and development. Many homeodomain genes arranged in genomic clusters determine anterior-posterior patterning, while others determine the fate of cells in specific tissues. The proliferation of cardiac myocytes and their differentiation early in development are dependent on the coordinate expression and action of serum response factor (SRF), GATA4 and the homeodomain factor Nkx2-5. All three of these factors are expressed in developing cardiomyocytes and induce expression of cardiac genes. Disruption of the Nkx2-5 gene in mice leads to embryonic lethality and defective cardiac development. SRF also plays a dual role in cardiac development, influencing both cardiomyocyte proliferation and differentiation depending on the stage and other signals that are present. In addition, the Hop (Homeodomain Only Protein) gene encodes a factor expressed early in cardiac development that is involved in cardiac differentiation. Hop inactivation in vertebrates leads to severe defects in cardiac development, acting downstream of Nkx2-5. Cardiac cells from mice lacking the Hop gene fail to exit the cell cycle in the normal manner, continuing to proliferate past the normal developmental stage. Many of the genes disregulated in the absence of Hop are involved in the cell cycle and are also targets of SRF. Although Hop is a homeodomain protein, it lacks a DNA-binding domain indicating that it must not regulate gene expression directly. Hop appears to regulate the expression of cardiac genes by binding to SRF and blocking DNA binding of SRF. The sequestration of SRF by Hop blocks the activation of cardiac genes, preventing normal cardiac development. The influence of Hop on the opposing processes of cardiomyocyte differentiation and proliferation reflect the interaction of Hop with SRF and the duel role SRF plays. In early cardiac development, Hop opposes differentiation induction b…
PMOID: PMO:00014376
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Homeodomain-Only Protein Pathway
Synonym: Hop Pathway in Cardiac Development
Tree Number: T4.1.10
database_cross_reference: NCI:C39107
database_cross_reference: NCI_BioC:C39107

Keratinocyte Differentiation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located in the basal layer. As cells leave the basal layer they undergo significant differentiation and biochemical and morphological remodeling. The final differentiation results in the formation of corneocytes. In vitro keratinocytes mimic this process. Several genes mark keratinocyte specific differentiation. Among the most frequently tracked markers are transglutaminase, cystatin and involucrin. Keratinocyte differentiation studies have identified and provided significant detail regarding the involvement of three of the 4 major MAP kinase pathways from several diverse stimuli such as EGF, FAS, TNF and calcium influx. The keratinocyte differentiation cascades also provide for detailed study of the functions of individual PKC isoforms and it is interesting to note the contrasting functions of the PKC isoforms in this process. In recent studies it has been determined that the cPKC (conventional/classical Protein Kinase C) isoforms, which are calcium-, phospholipid-, and diacylglycerol-dependent are inhibitory where as the nPKC (novel Protein Kinase C) isoforms which are calcium independent are stimulatory for keratinocyte differentiation markers. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014377
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Keratinocyte Differentiation
Tree Number: T4.1.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39135
database_cross_reference: NCI_BioC:C39135

Lissencephaly-1 Gene in Neuronal Migration and Development
type: Class
subclass of: Cell Differentiation or Development Pathway
PMOID: PMO:00014378
Subclass_of: Cell Differentiation or Development Pathway
Tree Number: T4.1.12

Macrophage Differentiation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Terminal differentiation of cells is often accompanied by repression of cellular proliferation, suggesting that there is a mechanism by which these cellular functions are coordinated. Macrophage differentiation is one model system in which this occurs; as macrophages differentiate, they also stop proliferating. Transcriptional regulation plays a key role in cell cycle progression as well as many differentiation processes. Ras stimulates cell cycle progression in part through Ets transcription factors that bind to cell cycle regulatory genes to activate their expression. Ets transcription factors also help to induce early macrophage differentiation. The activation of Ras signaling by M-CSF activates transcription of genes involved in differentiation through the coordinate expression of both Ets factors and AP-1. Other genes involved in cell cycle regulation coordinate action of E2F-1 and Ets transcription factors. Mets is a factor related in sequence to Ets2 that is upregulated during macrophage differentiation. Increased expression of the Mets protein during macrophage differentiation allows the creation of heterodimers with DP103 to act as transcriptional repressors of cell cycle progression genes, recruiting corepressor to promoters they interact with. DP103 is a gene previously identified as an RNA helicase involved in RNA processing that interacts with EBNA factors from Epstein Barr Virus. The transcriptional repression involving Mets with DP103 is selective, and does not involve all Ets regulated genes. While cell cycle genes are repressed by Mets, other genes activated by Ets factors such as those involved in differentiation are not repressed by Mets. The transcriptional repression by Mets also involved members of the Rb family of tumor suppressors, such as p107 and p130. This requirement for additional factors involved in regulating proliferation may allow for another level of control on cell proliferation and coordination with differentiation. (This definiti…
PMOID: PMO:00014379
Subclass_of: Cell Differentiation or Development Pathway
Synonym: METS affect on Macrophage Differentiation
Tree Number: T4.1.13
database_cross_reference: NCI:C39075
database_cross_reference: NCI_BioC:C39075

Melanocyte Development Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Studies with homozygous knockout mice have suggested that stem cell factor (SCF or KITLG), c-Kit, microphthalmia (Mitf), and B-cell CLL/lymphoma 2 (Bcl2) genes regulate melanocytic development. The SCF activation of Kit receptor leads to Mitf phosphorylation through the MAP kinase pathway. The activated Mitf recruits p300 and up-regulates Bcl2 transcription, which plays an important role in modulating the development and survival of the melanocyte lineage. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014380
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Melanocyte Development and Pigmentation Pathway
Tree Number: T4.1.14
database_cross_reference: NCI:C39150
database_cross_reference: NCI_BioC:C39150

Nephrin Signaling Pathway in the Kidney Podocyte
type: Class
subclass of: Cell Differentiation or Development Pathway
PMOID: PMO:00014381
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Nephrin/Neph1 signaling in the kidney podocyte
Tree Number: T4.1.15
database_cross_reference: NCI:C91637
database_cross_reference: NCI_PID:C91637

Neuronal Survival Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF and neurotrophin-3 that stimulate the survival of the associated neuron. Local signaling by activated Trk receptors at the synaptic terminus mediates some presynaptic neuronal responses to neurotrophins. Map kinase pathways activated by Trk receptor activate Erk1 and Erk2 at the terminus stimulating axonal growth, and PI3K activates AKT in the terminus as well. Activation of these kinases does not propagate a signal to the cell body though and does not induce a transcriptional response. This local signaling at the terminus or local signaling at the cell body appears distinct from the signaling pathway that transduces the survival signal from the target tissue. Retrograde axonal transport plays an essential role in neuronal survival induced by neurotrophins released at the target tissue. Failure of retrograde neurotrophin signaling may play a role in neurodegenerative conditions. The neuronal survival signal is initiated by binding of neurotrophins to Trk receptors in the presynaptic membrane, and then travels back along the axon to the neuronal cell body. To transmit the signal back along the axon, activated Trk receptors are internalized through receptor-mediated endocytosis and receptor containing vesicles then rapidly travel back to the cell body along axonal microtubules. Several reports indicate that neurotrophins remain receptor-bound during the retrograde axonal transport to the cell body, but recently it was reported that retrograde transport of NGF was not required to induce neuronal survival. Once in the cell body, Trk receptors activate multiple pathways. A key pathway activated by Trk after retrograde transport involves Erk5, also called BMK1. Trk activates Mek5, which activates Erk5, inducing phosphorylation of the CREB and Mef2 transcription factors. Erk5 does not directly phosphorylate CREB, but transloca…
PMOID: PMO:00014382
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Role of Erk5 in Neuronal Survival
Tree Number: T4.1.16
database_cross_reference: NCI:C39071
database_cross_reference: NCI_BioC:C39071

Neurotrophin Signaling Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and negative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.
PMOID: PMO:00014383
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Neurotrophin signaling pathway
Synonym: neurotrophin receptor signaling pathway
Synonym: neurotrophin signaling pathway
Tree Number: T4.1.17
database_cross_reference: GO:GO:0038179
database_cross_reference: NCI:C91443
database_cross_reference: NCI_KEGG:C91443

Oocyte Maturation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Progesterone (Pg) binds to both intracellular iPR and plasma membrane-bound mPR. After binding to Pg, iPR is recruited to the membrane associated protein tyrosine kinase p60c-src, which induces activation of the MAPK signaling pathway. This results in activation of p90Rsk and the subsequent phosphorylation and inactivation of Myt1, which favors formation of the activated cell cycle complex cyclin B-Cdc2. Activation of cyclin B-Cdc2 causes breakdown of the germinal vesicle and the initiation of oocyte maturation. In contrast, binding of Pg to mPR leads to inhibition of adenylyl cyclase (AC) through activation of Gai or inhibition of Gas. This leads to a decrease in the cAMP-dependent kinase PKA, which relieves inhibition of Cdc25C and also indirectly promotes the activation of MAPK signaling. PKA also regulates the initiation of oocyte maturation through other effects that are independent of PKA activity. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014384
Subclass_of: Cell Differentiation or Development Pathway
Synonym: How Progesterone Initiates the Oocyte Maturation
Tree Number: T4.1.18
database_cross_reference: NCI:C39156
database_cross_reference: NCI_BioC:C39156

Progesterone-Mediated Oocyte Maturation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
PMOID: PMO:00014385
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Progesterone-mediated oocyte maturation
Tree Number: T4.1.19
database_cross_reference: NCI:C91492
database_cross_reference: NCI_KEGG:C91492

Segmentation Clock Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation, a specialized mesodermal structure called the somite gives rise to skeletal muscles, vertebrae, and some dermis. Formation of the somites is a rhythmic process that involves an oscillator, the segmentation clock, driven by Wnt and Notch signaling. The clock ticks in somite precursors and halts when they reach a specific maturation stage defined as the wavefront, established by FGF and Wnt signaling. Lunatic fringe was shown to act downstream of Notch and to bind and negatively regulate its own promoter. Another cyclic gene is hes1. It acts also downstream of Notch and codes for an unstable protein able to negatively regulate its own promoter too. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014386
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Segmentation Clock
Tree Number: T4.1.20
database_cross_reference: NCI:C39104
database_cross_reference: NCI_BioC:C39104

Signal Dependent Regulation of Myogenesis Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds to promoters to activate genes involved in muscle cell differentiation. One of the factors that regulates the role of MyoD/MEF2 in myogenesis is the protein MEF2-interacting transcription repressor (MITR), a transcriptional repressor. When MITR is bound to MEF2, myogenesis genes are repressed rather than being activated. The transcriptional repression by MITR occurs in part at least through interaction with the CtBP (carboxy-terminal binding protein) corepressor. The inhibitory activity of MITR is itself regulated by the calmodulin dependent protein kinase CAMK. When CAMK is activated by factors such as IGF-1, it phosphorylates two specific residues in MITR, ser218 and ser448. Phosphorylated MITR does not bind to MEF2, but does bind to the protein 14-3-3, helping to block the repression of myogenesis. CAMK also plays a role in myogenesis through phosphorylation of histone deacetylase (HDAC), in which HDAC alters chromatin to repress myogenesis. Like MITR, phosphorylation of HDAC removes the repression, allowing myogenesis to continue. MITR shares sequence homology with HDAC, but itself lacks the enzyme motif. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014387
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Signal Dependent Regulation of Myogenesis by Corepressor MITR
Tree Number: T4.1.21
database_cross_reference: NCI:C39155
database_cross_reference: NCI_BioC:C39155

Skeletal Myogenesis Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to MyoD and other basic helix-loop-helix factors to activate transcription of genes involved in muscle cell differentiation. Transcriptional activation by MEF2 is blocked by interaction with HDAC5 and other histone deacetylases. In undifferentiated myoblasts, HDAC5 is present in the nucleus where it binds to MEF2 to block activation of muscle genes. When activated by IGF-1 signaling, CaM kinase phosphorylates HDAC proteins, causing them to be exported from the nucleus, releasing the block on MEF2 transcriptional activation and allowing differentiation to proceed. Transcription cofactors also interact with MEF2 to contribute to gene regulation and myogenesis. The transcriptional regulator NFAT, for example, acts as a cofactor for MEF2 when calcium and calcineurin signaling activate it. There are four members of the Mef2 gene family, Mef2a-2d. Mef2a is expressed in brain, heart and skeletal muscle. Mef2c is involved in myogenesis in cardiac and skeletal muscle. Mef2d is widely expressed, and may be involved in the regulation of T cell function as well as muscle. Several factors regulate Mef2 transcription factors, including Map kinases and histone deacetylase (HDAC) enzymes. Mef2 is phosphorylated by p38 map kinase, and phosphorylation of Mef2c by p38 contributes to skeletal muscle differentiation. BMK-1 (also called Erk5) is another member of the Map kinase family that regulates the activity of Mef2 family members and is unique in that it appears itself to possess a transcriptional activation domain and act as a transcriptional coactivator. Mekk3 disruption prevented normal cardiovascular development in mice and appears to signal through p38 and Mef2c in normal cardiovascular development. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014388
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)
Tree Number: T4.1.22
database_cross_reference: NCI:C39102
database_cross_reference: NCI_BioC:C39102

Small Leucine-Rich Proteoglycan (SLRP) Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: The small leucine-rich proteoglycans (SLRPs) are a family of proteins that are present in extracellular matrix and that share in common multiple repeats of a leucine-rich structural motif, flanked by cysteine residues. These proteins appear to interact in many cases with collagen, modifying the deposition and arrangement of collagen fibers in the extracellular matrix, and also with cells and with soluble growth factors. The interaction of SLRPs with cells and with growth factors like TGF-beta may affect the proliferation of cells in addition to modifying the extracellular environment. Post-translational modification of SLRPs with carbohydrates and sulfate-containing groups appears to modify the function of SLRPs. Changes in SLRP expression and modification in cornea, atherosclerotic plaque, joints, bone, tendons, and kidney may be associated with disease progression in those tissues. Decorin is one SLRP expressed throughout the body that stabilizes collagen fibrils and that also antagonizes the action of the cytokine TGF-beta, blocking cell cycle progression, and potentially playing a role in cancer and wound healing. The SLRP biglycan is expressed in bone and other connective tissues and genetic disruption of biglycan in mice causes low bone mass similar to osteoporosis. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014389
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Small Leucine-Rich Proteoglycan (SLRP) Molecules
Tree Number: T4.1.23
database_cross_reference: NCI:C91302
database_cross_reference: NCI_BioC:C91302

Synaptic Junction Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: The postsynaptic density (PSD) is a submembranous structure at the postsynaptic membrane mainly at the excitatory synapses. The neurotransmitter receptors are assembled and fixed at the PSD, and several molecules implicated in the synaptic plasticity are also enriched. PSD-95/synapse-associated protein (SAP) 90 is involved in the molecular organization of these components of the PSD and essential for learning and memory. The common feature of these postsynaptic proteins is that they have PSD-95/Dlg/ZO-1 (PDZ) modular domains for protein-protein interaction. PDZ domains of these proteins directly recognize the C termini of their target proteins and are believed to play a central role in targeting and clustering of receptors to proper synaptic membranes. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014390
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Synaptic Proteins at the Synaptic Junction
Tree Number: T4.1.24
database_cross_reference: NCI:C39185
database_cross_reference: NCI_BioC:C39185

Th1/Th2 Differentiation Pathway
type: Class
subclass of: Cell Differentiation or Development Pathway
definition: Helper T cells are found in two distinct cell types, Th1 and Th2, distinguished by the cytokines they produce and respond to and the immune responses they are involved in. Th1 cells produce pro-inflammatory cytokines like IFN-g, TNF-b and IL-2, while Th2 cells produce the cytokines IL-4, IL-5, IL-6 and IL-13. The cytokines produced by Th1 cells stimulate the phagocytosis and destruction of microbial pathogens while Th2 cytokines like IL-4 generally stimulate the production of antibodies directed toward large extracellular parasites. IL-5 stimulates eosinophil responses, also part of the immune response toward large extracellular parasites. Th1 and Th2 are produced by differentiation from a non-antigen exposed precursor cell type, Thp. Exposure of Thp cells to antigen by antigen-presenting cells may result in their differentiation to Th0 cells, not yet committed to become either Th1 or Th2 cells, although the existence of Th0 cells is controversial. Cells committed as either Th1 or Th2 cells are called polarized, whether they are effector cells actively secreting cytokines or are memory cells. The stimulation of Thp cells by exposure to antigen-presenting cells induces the proliferation of undifferentiated cells, and their expression of IL-2 and IL-2 receptor. The differentiation of Th1 cells and Th2 cells depends on the cytokines they are exposed to. IL-12 causes Th1 differentiation and blocks Th2 cell production, while IL-4 causes Th2 differentiation and antagonizes Th1 development. IL-18 also induces Th1 differentiation. Polarized Th1 and Th2 cells also express distinct sets of chemokine receptors that further modify their homing and other cellular responses. Improved understanding of Th1 and Th2 differentiation will improve our overall understanding of the immune system, its response to infection, and aberrant responses that lead to disease. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014391
Subclass_of: Cell Differentiation or Development Pathway
Synonym: Th1/Th2 Differentiation
Tree Number: T4.1.25
database_cross_reference: NCI:C39252
database_cross_reference: NCI_BioC:C39252

Cell Motility Pathway
type: Class
subclass of: Biochemical Pathway
definition: An elaboration of the known steps and interactions required to allow cell movement.
PMOID: PMO:00014392
Subclass_of: Biochemical Pathway
Tree Number: T4.2
database_cross_reference: NCI:C39703

Actin Branching Pathway
type: Class
subclass of: Cell Motility Pathway
definition: Mammalian cell motility requires actin polymerization in the direction of movement to change membrane shape and extend cytoplasm into lamellipodia. The polymerization of actin to drive cell movement also involves branching of actin filaments into a network oriented with the growing ends of the fibers near the cell membrane. Manipulation of this process helps bacteria like Salmonella gain entry into cells they infect. Two of the proteins involved in the formation of Y branches and in cell motility are Arp2 and Arp3, both members of a large multiprotein complex containing several other polypeptides as well. The Arp2/3 complex is localized at the Y branch junction and induces actin polymerization. Activity of this complex is regulated by multiple different cell surface receptor signaling systems, activating WASP, and Arp2/3 in turn to cause changes in cell shape and cell motility. Wasp and its cousin Wave-1 interact with the Arp2/3 complex through the p21 component of the complex. The crystal structure of the Arp2/3 complex has revealed further insights into the nature of how the complex works. Activation by Wave-1, another member of the WASP family, also induces actin alterations in response to Rac1 signals upstream. Wave-1 is held in an inactive complex in the cytosol that is activated to allow Wave-1 to associate with Arp2/3. While WASP is activated by interaction with Cdc42, Wave-1, is activated by interaction with Rac1 and Nck. Wave-1 activation by Rac1 and Nck releases Wave-1 with Hspc300 to activate actin Y branching and polymerization by Arp2/3. Different members of this gene family may produce different actin cytoskeletal architectures. The immunological defects associated with mutation of the WASP gene, the Wiskott-Aldrich syndrome for which WASP was named, indicates the importance of this system for normal cellular function. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014393
Subclass_of: Cell Motility Pathway
Synonym: Y branching of actin filaments
Tree Number: T4.2.1
database_cross_reference: NCI:C38973
database_cross_reference: NCI_BioC:C38973

Actin Cytoskeleton Regulation Pathway
type: Class
subclass of: Cell Motility Pathway
PMOID: PMO:00014394
Subclass_of: Cell Motility Pathway
Synonym: Regulation of actin cytoskeleton
Tree Number: T4.2.2
database_cross_reference: NCI:C91435
database_cross_reference: NCI_KEGG:C91435

Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
type: Class
subclass of: Cell Motility Pathway
PMOID: PMO:00014395
Subclass_of: Cell Motility Pathway
Synonym: a4b1 and a4b7 Integrin signaling
Tree Number: T4.2.3
database_cross_reference: NCI:C91533
database_cross_reference: NCI_PID:C91533

Paxillin-Dependent Alpha4/Beta1 Integrin Signaling Pathway
type: Class
subclass of: Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
PMOID: PMO:00014396
Subclass_of: Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
Synonym: Paxillin-dependent events mediated by a4b1
Tree Number: T4.2.3.1
database_cross_reference: NCI:C91645
database_cross_reference: NCI_PID:C91645

Paxillin-Independent Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
type: Class
subclass of: Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
PMOID: PMO:00014397
Subclass_of: Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway
Synonym: Paxillin-independent events mediated by a4b1 and a4b7
Tree Number: T4.2.3.2
database_cross_reference: NCI:C91646
database_cross_reference: NCI_PID:C91646

Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway
type: Class
subclass of: Cell Motility Pathway
PMOID: PMO:00014398
Subclass_of: Cell Motility Pathway
Synonym: a6b1 and a6b4 Integrin signaling
Tree Number: T4.2.4
database_cross_reference: NCI:C91534
database_cross_reference: NCI_PID:C91534

AlphaM/Beta2 Integrin Signaling Pathway
type: Class
subclass of: Cell Motility Pathway
PMOID: PMO:00014399
Subclass_of: Cell Motility Pathway
Synonym: amb2 Integrin signaling
Tree Number: T4.2.5
database_cross_reference: NCI:C91537
database_cross_reference: NCI_PID:C91537

Calpain-1 Cell Spread Pathway
type: Class
subclass of: Cell Motility Pathway
definition: The mammalian calpain gene family currently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. Spreading cells display newly transiently formed integrin adhesion clusters containing Calpain1 (mu-Calpain), cleaved Talin, B3-Integrin, and SPTAN1 (Spectrin). Recruitment of Rac to these clusters leads to the activation of Rac and the formation of Rac-induced focal clusters. The Calpain1 in the integrin clusters initially inactivates RhoA allowing for the formation of lamellipodia. The subsequent activation of newly synthesized RhoA transforms these clusters into Focal Adhesion Complexes and the formation of contractile actin-myosin stress fibers. These mature adhesions do not contain calpain. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014400
Subclass_of: Cell Motility Pathway
Synonym: mu-Calpain Cell Spread Pathway
Synonym: uCalpain and friends in Cell spread
Tree Number: T4.2.6
database_cross_reference: NCI:C39262
database_cross_reference: NCI_BioC:C39262

Calpain-2 Cell Motility Pathway
type: Class
subclass of: Cell Motility Pathway
definition: The mammalian calpain gene family currently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. One of the most carefully studied functions of the calpains is the regulation of integrin-mediated cell migration. Calpains digest the links between the actin cytoskeleton and several focal adhesion complex proteins; talin, paxillin and focal adhesion kinase. The release from the focal adhesion complex facilitates migration. Calpastatin is an inhibitor expressed in most cells. Calpastatin binds the four inhibitory domains of calpain. Release from calpastatin does not activate calpain. Activation requires additional signaling, coactivators, and an appropriate calcium concentration. During cell migration calpain1 (mu-calpain) acts at the leading edge as a response to integrin signals or calcium fluctuations due to the stretch activated calcium channels. Calpain1 cleaves the target proteins, talin, ezrin, paxillin, and the cytoplasmic tail of the integrins B1(a) and B3(b) to release the adhesion and form new adhesions. Calpain2 (M-calpain) is believed to be membrane bound and functions at the trailing edge of the migrating cell to cleave the integrins in response to growth factor receptor signals. PKA functions to down regulate or inhibit calpain2. In Alzheimer's disease, amyloid peptides interfere with calpain activity causing a mislocalization of cdk5. Deregulated cdk5 hyperphosphorylates tau promoting cell death in neurons. Mutations in the muscle specific calpain p94 lead to Limb Girdle muscular dystrophy 2A (LGMD2A). Over activity of calpains due to elevated calcium leads to tissue damage in the heart and brain. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014401
Subclass_of: Cell Motility Pathway
Synonym: M-Calpain Cell Motility Pathway
Synonym: mCalpain and friends in Cell motility
Tree Number: T4.2.7
database_cross_reference: NCI:C39147
database_cross_reference: NCI_BioC:C39147

Cell Migration Pathway
type: Class
subclass of: Cell Motility Pathway
definition: Migration of cells is involved in essential functions such as development, invasiveness of cancer cells, leukocyte movement toward chemotactic signals, and fibroblast response to injury. Cells can migrate in a specific direction in response to extracellular signals through pathways that trigger changes in the cytoskeleton, particularly actin filaments, increasing lamellipodia and filopodia formation and decreasing focal adhesions. Factors like PDGF activate PI3 kinase and multiple pathways downstream to stimulate cell migration. One pathway regulating migration through the p85 regulatory subunit of PI3 kinase does not require PI3-kinase activity. In this pathway, p85 of PI3-kinase activates cdc42, which activates N-Wasp (Wiskott-Aldrich Syndrome Protein) to regulate ARP-2/3. ARP-2/3 is a complex of proteins localized at the leading edge of moving cells that nucleates the formation of new actin fibers and interacts with Wasp to stimulate migration. The cdc42 pathway also regulates p21-activate kinase 1 (PAK1). Another pathway by which PI3 kinase regulates migration is through the small GTPase Rac. PAK1 is a downstream target of Rac as well as cdc42. Downstream of Rac and PAK1, Myosin light chain kinase (MLCK) phosphorylates myosin light chain to increase cell migration. The regulation of the localization and activity of signaling factors creates coordinated pathways linking extracellular signals and cellular migration. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014402
Subclass_of: Cell Motility Pathway
Synonym: Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration
Tree Number: T4.2.8
database_cross_reference: NCI:C39021
database_cross_reference: NCI_BioC:C39021

Extracellular Matrix Binding Pathway
type: Class
subclass of: Cell Motility Pathway
definition: Activation of the MAPK kinase pathway has been identified as a mechanism that integrins use to regulate gene expression, leading to cell shape changes during cell spreading or migration. Epithelial cells respond to extracellular matrix (ECM) causing integrin-mediated FAK phosphorylation; this, in turn, phosphorylates the surrounding proteins (paxillin, Fyn/shc, and src) and leads to signal amplification. FAK also binds PI-3 kinase and acts upstream in the MAP kinase pathway. When MAP kinase or PI-3 kinase is inhibited, actin reorganization is blocked. Src phosphorylates p190RhoGAP, inactivating its GAP function and allowing RhoGTP to stay active longer, promoting further signal amplification. Activated RhoGTP binds to downstream kinases such as Rho-associated coiled coil-containing protein kinase (p160ROCK) and p140 diaphanous (p140Dia) to increase actin polymerization and contraction. Actin reorganization assists integrin clustering, allowing more ECM binding that increase FAK phosphorylation and other signal transduction events. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014403
Subclass_of: Cell Motility Pathway
Synonym: Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
Tree Number: T4.2.9
database_cross_reference: NCI:C39054
database_cross_reference: NCI_BioC:C39054

Focal Adhesion Pathway
type: Class
subclass of: Cell Motility Pathway
definition: Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signaling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signaling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signaling.
PMOID: PMO:00014404
Subclass_of: Cell Motility Pathway
Synonym: Focal Adhesion
Synonym: Focal adhesion pathway
Synonym: Integrin-mediated Cell Adhesion
Synonym: Integrin-mediated Cell Adhesion Pathway
Synonym: cell adhesion mediated by integrin
Synonym: cell adhesion mediated by integrin complex
Tree Number: T4.2.10
database_cross_reference: GO:GO:0033627
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38829
database_cross_reference: NCI_KEGG:C38829

Granulocyte Adhesion Pathway
type: Class
subclass of: Cell Motility Pathway
definition: Cell adhesion is a fundamental feature of multicellular organisms including their defense mechanisms. In the later case in mammals, leukocytes play central role. They bind bacteria, parasites, viruses, tumor cells etc. Furthermore, their interactions with the endothelium are of special importance. During an inflammation or immune reaction, specialized leukocytes (eosinophilic granulocytes) adhere to and pass through the endothelium of the blood vessels and the underlying matrix. The reaction passes through the following steps: 1. Rolling (the flow of cells is slowed down by first making contacts to the endothelium via P-, E-, and L-selectins and their receptors); 2. Adhesion (After activation of leukocyte integrins, firm contacts are established between them and endothelium molecules of the Ig superfamily - LFA-1, Mac-1, VLA-4 etc.); 3. Flattening of the cells and diapedesis (Adhering leukocytes crawl to an intercellular junction of the endothelium and then transmigrate to or even through the intercellular matrix. This is mediated by homophilic interactions of PECAM and CD31. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014405
Subclass_of: Cell Motility Pathway
Synonym: Adhesion and Diapedesis of Granulocytes
Tree Number: T4.2.11
database_cross_reference: NCI:C39097
database_cross_reference: NCI_BioC:C39097

LIS1 Pathway
type: Class
subclass of: Cell Motility Pathway
definition: LIS1 can bind to MT bundles; however, phospho-LIS1 binding to MT bundles is mediated through the distal zinc finger motif of CLIP-170. When the distal zinc finger motif of CLIP-170 is mutated, the phospho-LIS1 isoform can no longer bind to MT bundles. This can also explain why p150/dynactin is not recruited to the MT bundles. CLIP-170 targets the dynein/dynactin complex to the MT, using phopho-LIS1 as an adapter; the motor complex, being in the proximity of the MT, associates with it. The initial static link to the MT provided by CLIP-170 is released by its hyperphosphorylation and the retrograde dynein/dynactin-dependent movement of the cargo (endocytic vesicle, kinetochore, etc.) takes place. Doublecortin (DCX) is placed close to the LIS1 pathway based on its interaction with LIS1 and its role in microtubule dynamics. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014406
Subclass_of: Cell Motility Pathway
Synonym: Lissencephaly gene (LIS1) in neuronal migration and development
Synonym: Lissencephaly-1 Gene in Neuronal Migration and Development
Synonym: PAFAH1B1 Gene in Neuronal Migration and Development
Tree Number: T4.2.12
database_cross_reference: NCI:C39140
database_cross_reference: NCI:C91630
database_cross_reference: NCI_BioC:C39140
database_cross_reference: NCI_PID:C91630

Lymphocyte Adhesion Pathway
type: Class
subclass of: Cell Motility Pathway
definition: Cell adhesion is a fundamental feature of multicellular organisms including their defense mechanisms. In the later case in mammals, leukocytes play a central role. They bind bacteria, parasites, viruses, tumor cells, etc. Furthermore, their interactions with the endothelium are of special importance. Generally, lymphocyte adhesion and passage from the bloodstream to the lymphatic system occurs in the high endothelial venules of the lymph nodes. This way the lymphocytes can communicate with each other in the lymphatic system and search for foreign compounds after their recirculation to the bloodstream, thus fulfilling their role in the immune system. The reaction passes through the following steps: 1. Rolling, the flow of cells is slowed down by first making contacts to the endothelium via P-, E-, and L-selectins and their receptors; 2. Adhesion, after activation of leukocyte integrins, firm contacts are established between them and endothelium molecules of the Ig superfamily (e.g., LFA-1, Mac-1, VLA-4); 3. Flattening of the cells and diapedesis, adhering leukocytes crawl to an intercellular junction of the endothelium and then transmigrate to or even through the intercellular matrix. This is mediated by homophilic interactions of PECAM and CD31. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014407
Subclass_of: Cell Motility Pathway
Synonym: Adhesion and Diapedesis of Lymphocytes
Tree Number: T4.2.13
database_cross_reference: NCI:C39142
database_cross_reference: NCI_BioC:C39142

Disease Pathway
type: Class
subclass of: Biochemical Pathway
definition: A sequence of biological or biochemical events that are manifest during the course of a disease.
PMOID: PMO:00014408
Subclass_of: Biochemical Pathway
Tree Number: T4.3
database_cross_reference: NCI:C39701

Acute Myocardial Infarction Pathway
type: Class
subclass of: Disease Pathway
definition: Myocardial infraction (MI) is the condition of irreversible necrosis of the heart muscle that results from prolonged ischemia. Nearly 1.5 million people in US sustain an MI each year, and this event proves fatal in approximately one third of patients. Approximately 90% of MI results from formation of an acute thrombus that obstructs an atherosclerotic coronary artery. The thrombus transforms a region of plaque narrowing to one of complete vessel occlusion. The responsible thrombus appears to be generated by interactions between the atherosclerotic plaque, the coronary endothelium, circulating platelets, and dynamic vasomotor tone of the vessel wall, all of which overwhelm natural protective mechanisms. The endogenous protective mechanisms against thrombosis include: 1) Inactivation of thrombin by antithrombin III (ATIII), the effectiveness of which is enhanced by binding of ATIII to heparin sulfate. The antithrombin binding region of commercial heparin consists of sulfated disaccharide units; 2) Inactivation of clotting factors Va and VIIIa by activated protein C (protein C*), an action that is enhanced by protein S. Protein C is activated by the thrombomodulin (TM)-thrombin complex; 3) Inactivation of factor VII/tissue factor complex by tissue factor pathway inhibitor (TFPI). Coumarin drugs (Warfarin) blocks the g-carboxylation of Glu residues in prothrombin and factors VII, IX and X which results in incomplete molecules that are biologically inactive in coagulation (left panel); 4) Lysis of fibrin clots by tissue plasminogen activator (tPA); 5) Inhibition of platelet activation by prostacyclin and EDRF-NO. Platelets adhere to exposed collagen and are activated at the site of endothelial damage in the blood vessel. Activated platelets release adenosine diphosphate (ADP), serotonin (5-HT), and thromboxane A2 (TXA2), which activate additional platelets. Binding of thrombin further activates the platelets. Three adjoining platelets are shown in the process of viscous …
PMOID: PMO:00014409
Subclass_of: Disease Pathway
Synonym: Acute Myocardial Infarction
Tree Number: T4.3.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38985
database_cross_reference: NCI_BioC:C38985

Allograft Rejection Pathway
type: Class
subclass of: Disease Pathway
definition: After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
PMOID: PMO:00014410
Subclass_of: Disease Pathway
Synonym: Allograft rejection
Tree Number: T4.3.2
database_cross_reference: NCI:C91452
database_cross_reference: NCI_KEGG:C91452

Arrhythmogenic Right Ventricular Cardiomyopathy Pathway
type: Class
subclass of: Disease Pathway
definition: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are progressive myocyte loss and fibrofatty replacement, with a predilection for the right ventricle. A number of genetic studies have identified mutations in various components of the cardiac desmosome that have important roles in the pathogenesis of ARVD/C. Disruption of desmosomal function by defective proteins might lead to death of myocytes under mechanical stress. The myocardial injury may be accompanied by inflammation. Since regeneration of cardiac myocytes is limited, repair by fibrofatty replacement occurs. Several studies have implicated that desmosome dysfunction results in the delocalization and nuclear translocation of plakoglobin. As a result, competition between plakoglobin and beta-catenin will lead to the inhibition of Wnt/beta-catenin signaling, resulting in a shift from a myocyte fate towards an adipocyte fate of cells. The ryanodine receptor plays a crucial part in electromechanical coupling by control of release of calcium from the sarcoplasmic reticulum into the cytosol. Therefore, defects in this receptor could result in an imbalance of calcium homeostasis that might trigger cell death.
PMOID: PMO:00014411
Subclass_of: Disease Pathway
Synonym: ARVC Pathway
Synonym: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Tree Number: T4.3.3
database_cross_reference: NCI:C91454
database_cross_reference: NCI_KEGG:C91454

Asthma Pathway
type: Class
subclass of: Disease Pathway
definition: Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into Th2 cells, a process that is promoted by interleukin 4 (IL-4). Activated Th2 cells stimulate B cells to produce IgE antibodies in response to IL-4 and IL-13. IgE binds the high affinity IgE receptor at the surface of mast cells, the proliferation and differentiation of which is promoted by IL-9.The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Activated mast cells and Th2 cells also induce the production of IL-5. IL-5 travels to the bone marrow and regulates the differentiation and egress of eosinophils from the bone marrow into the blood. Moreover activated mast cells and Th2 cells in the lung generate the cytokines interleukin IL-4, IL-13 and tumour necrosis factor (TNF)-alpha. These cytokines stimulate the generation of eotaxin by lung epithelial cells, fibroblasts and smooth muscle cells. Eotaxin then stimulates the selective recruitment of eosinophils from the airway microvessels into the lung tissue. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation.
PMOID: PMO:00014412
Subclass_of: Disease Pathway
Synonym: Asthma
Tree Number: T4.3.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91488
database_cross_reference: NCI_KEGG:C91488

Autoimmune Thyroid Disease Pathway
type: Class
subclass of: Disease Pathway
definition: The classification of autoimmune thyroid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroiditis or primary myxedema.
PMOID: PMO:00014413
Subclass_of: Disease Pathway
Synonym: Autoimmune thyroid disease
Tree Number: T4.3.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91510
database_cross_reference: NCI_KEGG:C91510

Cancer Pathway
type: Class
subclass of: Disease Pathway
PMOID: PMO:00014414
Subclass_of: Disease Pathway
Synonym: Human Diseases; Cancers
Synonym: Pathways in cancer
Tree Number: T4.3.6
database_cross_reference: NCI:C91436
database_cross_reference: NCI_KEGG:C91436

Acute Myeloid Leukemia Pathway
type: Class
subclass of: Cancer Pathway
definition: Two major types of genetic events are crucial for the molecular pathogenesis of acute myeloid leukemias (AML): activating mutations of signal transduction intermediates and alterations in myeloid transcription factors governing hematopoietic differentiation. Both aberrant and constitutive activation of signal transduction molecules are found in about 50% of primary AML bone marrow samples, and seem to contribute to the increased proliferation and apoptosis resistance. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Specific haematopoietic transcription factors are crucial for differentiation to particular lineages during normal differentiation, but are frequently disrupted in AML. Some mechanisms of disruption involve the effect of fusion proteins that are generated by chromosomal translocations on haematopoietic transcription factors. In other cases, the transcription factors themselves are mutated.
PMOID: PMO:00014415
Subclass_of: Cancer Pathway
Synonym: AML Pathway
Synonym: Acute myeloid leukemia
Tree Number: T4.3.6.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91526
database_cross_reference: NCI_KEGG:C91526

Basal Cell Carcinoma Pathway
type: Class
subclass of: Cancer Pathway
definition: The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. Normally, ligand-dependent signaling by Hedgehog (Hh) homologs proceeds through binding to the Patched receptor. This binding relieves the Patched-mediated inhibition of signaling through the Smoothened (SMOH) gene product. This signaling ultimately results in the dissociation of the Gli1 transcription factor from an inhibitory complex in the cytoplasm, its subsequent translocation to the nucleus, and activation of target gene expression. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
PMOID: PMO:00014416
Subclass_of: Cancer Pathway
Synonym: Basal cell carcinoma
Tree Number: T4.3.6.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91513
database_cross_reference: NCI_KEGG:C91513

Bladder Cancer Pathway
type: Class
subclass of: Cancer Pathway
definition: Bladder cancers arise and progress along two distinctive pathways. The first of these is often preceded by simple and papillary hyperplasia and exhibits a tumour morphology that is low-grade, superficial and papillary. Papillary carcinoma has a tendency to recur locally, but rarely invades and metastasizes. These tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. The second tumour pathway is characterized by high-grade muscle-invasive tumours, which either originate from flat carcinoma in situ (CIS)/severe dysplasia or arise de novo. Over half of these tumours show defects in the tumour suppressors p53 and/or the retinoblastoma protein (RB) genes and pathways, and over 50% of these tumours progress to local and distant metastases. Some of the cell cycle-related molecules show evidence of epigenetic modulation through aberrant promoter hypermethylation in invasive bladder cancer. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF).
PMOID: PMO:00014417
Subclass_of: Cancer Pathway
Synonym: Bladder cancer
Tree Number: T4.3.6.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91458
database_cross_reference: NCI_KEGG:C91458

Chronic Myeloid Leukemia Pathway
type: Class
subclass of: Cancer Pathway
definition: Chronic myelogenous leukaemia (CML) is a biphasic disease, initiated by expression of the BCR/ABL fusion gene product in self-renewing, haematopoietic stem cells (HSCs). HSCs can differentiate into common myeloid progenitors (CMPs), which then differentiate into granulocyte/macrophage progenitors (GMPs). HSCs can also differentiate into common lymphoid progenitors (CLPs), which are the progenitors of lymphocytes such as T cells and B cells. The initial chronic phase of CML (CML-CP) is characterized by a massive expansion of the granulocytic-cell series. Acquisition of additional genetic mutations beyond expression of BCR/ABL causes the progression of CML from chronic phase to blast phase (CML-BP), characterized by an accumulation of myeloid or lymphoid blast cells.
PMOID: PMO:00014418
Subclass_of: Cancer Pathway
Synonym: CML Pathway
Synonym: Chronic myeloid leukemia
Tree Number: T4.3.6.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91465
database_cross_reference: NCI_KEGG:C91465

Colorectal Cancer Pathway
type: Class
subclass of: Cancer Pathway
definition: Classically, colorectal cancer (CRC) has been believed to develop from normal mucosa through the premalignant adenoma by the step-wise accumulation of mutations. All CRC display either microsatellite instability (MSI) or chromosome instability (CIN). MSI occurs in 15% of colon cancers and results from inactivation of the DNA mismatch repair (MMR) system by either MMR gene mutations or hypermethylation of the MLH1 promoter. MSI promotes tumorigenesis through generating mutations in target genes that possess coding microsatellite repeats, such as beta-catenin, TGFBR2 and BAX. CIN is found in the majority of colon cancers and leads to a different pattern of gene alterations that contribute to tumor formation. Genes involved in CIN are those coding for APC, K-ras, SMAD4 and p53.
PMOID: PMO:00014419
Subclass_of: Cancer Pathway
Synonym: CRC Pathway
Synonym: Colorectal cancer
Tree Number: T4.3.6.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91466
database_cross_reference: NCI_KEGG:C91466

Endometrial Cancer Pathway
type: Class
subclass of: Cancer Pathway
definition: Two types of endometrial carcinoma are distinguished with respect to biology and clinical course.
PMOID: PMO:00014420
Subclass_of: Cancer Pathway
Synonym: Endometrial cancer
Tree Number: T4.3.6.6
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91528
database_cross_reference: NCI_KEGG:C91528

Glioblastoma Multiforme Pathway
type: Class
subclass of: Cancer Pathway
definition: Glioblastoma multiforme (GBM) formation is either de novo (primary GBMs) or due to the progression of a lower grade glioma to a higher grade one through the acquisition of additional mutations (secondary GBMs). In primary GBM, disruption of the p53 pathway often occurs through loss of ARF, or less frequently through amplification of MDM2. Disruption of the RB pathway occurs through loss of INK4A. Amplification and/or mutation of the epidermal growth factor receptor (EGFR) is the most frequently detected genetic defect that is associated with primary GBM. In secondary GBM, loss of p53 and activation of the growth-factor-receptor-tyrosine-kinase signaling pathway (such as through overexpression of PDGF/PDGFR) initiates tumour formation, whereas disruption of the retinoblastoma (RB) pathway contributes to the progression of tumour development. Loss of PTEN has been implicated in both pathways, although it is much more common in the pathogenesis of primary GBM.
PMOID: PMO:00014421
Subclass_of: Cancer Pathway
Synonym: GBM Pathway
Synonym: Glioma
Synonym: Glioma Pathway
Tree Number: T4.3.6.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91479
database_cross_reference: NCI_KEGG:C91479

Melanoma Pathway
type: Class
subclass of: Cancer Pathway
definition: Five distinct stages have been proposed in the evolution of melanoma on the basis of histological criteria: common acquired and congenital nevi without dysplastic changes; dysplastic nevi with structural and architectural atypia; radial-growth phase (RGP) melanoma; vertical-growth phase (VGP) melanoma; and metastatic melanoma. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Moreover, melanoma development is strongly associated with inactivation of the p16INK4a/CDK4,6/pRb and p14ARF/HMD2/p53 tumor suppressor pathways. The vertical-growth phase and metastatic melanoma are notable for striking changes in the control of cell adhesion. Recently, amplification of the MITF gene was demonstrated in 10% of primary melanomas and 20% of metastatic melanomas, suggesting that MITF is a melanoma oncogene.
PMOID: PMO:00014422
Subclass_of: Cancer Pathway
Synonym: Melanoma
Tree Number: T4.3.6.8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91477
database_cross_reference: NCI_KEGG:C91477

Non-Small Cell Lung Cancer Pathway
type: Class
subclass of: Cancer Pathway
definition: Non-small-cell lung cancer (NSCLC) accounts for approximately 80% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS and c-erbB-2, and inactivation of tumor suppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactivate GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Overexpression of c-erbB-2 or EGFR leads to a proliferative advantage. Inactivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a gene inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6. Loss of p16INK4a expression is a common feature of NSCLC RAR-beta is a nuclear receptor that bears vitamin-A-dependent transcriptional activity. RASSF1A is able to form heterodimers with Nore-1, an RAS effector. Therefore, loss of RASSF1A might shift the balance of RAS activity towards a growth-promoting effect.
PMOID: PMO:00014423
Subclass_of: Cancer Pathway
Synonym: NSCLC Pathway
Synonym: Non-small cell lung cancer
Tree Number: T4.3.6.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91445
database_cross_reference: NCI_KEGG:C91445

Pancreatic Cancer Pathway
type: Class
subclass of: Cancer Pathway
definition: Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands. Pancreatic ductal adenocarcinoma (PDA) show elevated expression of EGF receptors (e.g. HER2/neu) and their ligands (e.g. TGF-alpha) consistent with the presence of this autocrine loop. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signaling pathway.
PMOID: PMO:00014424
Subclass_of: Cancer Pathway
Synonym: Pancreatic cancer
Tree Number: T4.3.6.10
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91446
database_cross_reference: NCI_KEGG:C91446

Papillary Thyroid Carcinoma Pathway
type: Class
subclass of: Cancer Pathway
definition: Papillary thyroid carcinoma (PTC), the most frequent neoplasia originating from the thyroid epithelium, accounts for about 80% of all thyroid cancers. Chimeric oncogenes, created by chromosomal rearrangements involving prevalently RET and, to a less extent, NTRK1 loci, are implicated in the development of papillary carcinoma. These are inappropriately expressed and stimulate constitutive signaling, bypassing the need for receptor activation by growth factors. Alternatively, mutant RAS directly stimulates BRAF, whereas mutant BRAF directly stimulates MEK.
PMOID: PMO:00014425
Subclass_of: Cancer Pathway
Synonym: PTC Pathway
Synonym: Thyroid Cancer Pathway
Synonym: Thyroid cancer
Tree Number: T4.3.6.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91496
database_cross_reference: NCI_KEGG:C91496

Prostate Cancer Pathway
type: Class
subclass of: Cancer Pathway
definition: The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes that catalyze conjunction of glutathione with harmful, electrophilic molecules, thereby protecting cells from carcinogenic factors. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by such carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. After therapeutic reduction in the levels of testosterone and dihydrotestosterone, the emergence of androgen-independent prostate cancer has been associated with mutations in the androgen receptor (AR) that permit receptor activation by other ligands, increased expression of androgen receptors accompanying AR amplification, and ligand-independent androgen-receptor activation.
PMOID: PMO:00014426
Subclass_of: Cancer Pathway
Synonym: Prostate cancer
Tree Number: T4.3.6.12
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91517
database_cross_reference: NCI_KEGG:C91517

Renal Cell Carcinoma Pathway
type: Class
subclass of: Cancer Pathway
definition: Renal cell carcinoma (RCC) is a heterogeneous term comprising a group of neoplasms of renal origin. There are 4 major histologic subtypes of RCC: conventional (clear cell RCC, 75%), papillary (15%), chromophobic (5%), and collecting duct (2%). Multiple genes are involved in the molecular pathogenesis of RCC. VHL is a tumor suppressor gene responsible for hereditary (von Hippel-Lindau) and sporadic variants of conventional (clear cell) RCC. In the absence of VHL, hypoxia-inducible factor alpha (HIF-alpha) accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. An oncogene, MET has been found to be mutant in cases of hereditary papillary renal cancer (HPRC), although the incidence of c-MET mutations is low in sporadic papillary RCC. Once activated, MET mediates a number of biological effects including motility, invasion of extracellular matrix, cellular transformation, prevention of apoptosis and metastasis formation. Mutations in the fumarate hydratase (FH) gene cause hereditary leiomyomatosis and renal cancer syndrome (HLRCC) papillary renal tumors, although the incidence of FH mutations in sporadic tumors is unknown. Loss of functional FH leads to accumulation of fumarate in the cell, triggering inhibition of HPH and preventing targeted pVHL-mediated degradation of HIF-alpha. BHD mutations cause the Birt-Hogg-Dube syndrome and its associated chromophobe, hybrid oncocytic, and conventional (clear cell) RCC. The incidence of BHD mutations in sporadic renal tumors is not known.
PMOID: PMO:00014427
Subclass_of: Cancer Pathway
Synonym: Renal cell carcinoma
Tree Number: T4.3.6.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91501
database_cross_reference: NCI_KEGG:C91501

Small Cell Lung Cancer Pathway
type: Class
subclass of: Cancer Pathway
definition: Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 20% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumor suppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.
PMOID: PMO:00014428
Subclass_of: Cancer Pathway
Synonym: SCLC Pathway
Synonym: Small cell lung cancer
Tree Number: T4.3.6.14
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91502
database_cross_reference: NCI_KEGG:C91502

Cancer Susceptibility Pathway
type: Class
subclass of: Disease Pathway
definition: BRCA1 and BRCA2 were identified genetically as breast cancer susceptibility genes when a single copy of the gene is mutated and are involved in the cellular response to DNA damage, including blocking cell cycle progression and inducing DNA repair to preserve the integrity of the genome during cell division. BRCA1 and BRCA2 induce double-stranded repair of breaks using homologous recombination, in part through activation of RAD51. BRCA1 acts as a ubiquitin ligase targeting the protein FancD2 that activates checkpoint control, integrating the ATM response to ionizing radiation and the FA response to cross-linking agents like mitomycin C. Mutation of one of the several components of the FA complex involved in maintaining integrity of the genome leads to the condition Fanconi anemia. One member of the FA complex was recently identified as BRCA2, which leads to Fanconi anemia when both copies of the gene are mutated. Another related factor involved in the response of cells to DNA damage is the kinase ATM. ATM is mutated in patients with AT, a condition with many similar traits to Fanconi anemia. Like ATM, ATR serves as a checkpoint kinase that halts cell cycle progression and induces DNA repair when DNA is damaged. Loss of ATR results in a loss of checkpoint control in response to DNA damage, leading to cell death. Deletion of the ATR gene in mice is embryonic lethal. ATRIP is a protein that interacts with ATR and is a substrate for its kinase activity. ATRIP is required for ATR function, and removal of ATRIP also leads to a loss of checkpoint control of the cell cycle. ATR and ATM kinase targets include repair enzymes like Rad51, and the checkpoint kinases Chk1 and Chk2, as well as BRCA1 and BRCA2. The close relationship of the genes involved in breast cancer and Fanconi anemia has helped illuminate this signaling system, and may help lead to improved understanding and treatment of these conditions. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014429
Subclass_of: Disease Pathway
Synonym: Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility
Tree Number: T4.3.7
database_cross_reference: NCI:C38997
database_cross_reference: NCI_BioC:C38997

Cardiac Hypertrophy Pathway
type: Class
subclass of: Disease Pathway
definition: One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickness of the ventricular walls. Cardiac hypertrophy allows the heart to handle the increased stress caused by elevated blood pressure but is also a risk factor associated with heart disease. Cardiac hypertrophy results from cross-talk between G-protein coupled receptor signaling and the EGF receptor pathway. Several GPCR ligands are known to stimulate cardiac hypertrophy, including factors that regulate blood pressure such as angiotensin II and endothelin-1. These factors stimulate phospholipase C through Gq activation, and the production of 1P3 and diacylglycerol second messengers. PKC-delta is activated by DAG and interacts with the metalloproteinase ADAM12. ADAM12 cleaves the membrane-bound HB-EGF to release soluble EGF ligand that activates EGF receptor in myocardial cells. EGF receptor activation downstream through small G proteins and the MAP kinase pathway ultimately leads to cardiac hypertrophy. Signals by GPCR ligands such as angiotensin II result in transcriptional translation of immediate early genes like fos and other genes involved in long-term remodeling of heart tissue and the physiological response to stress in the heart such as the atrial natriuretic factor. Factors such as the AKT kinase, reactive oxygen species (ROS) and NE-kB also are involved in signaling that leads to hypertrophy, although their role is not yet clear. Blocking this pathway at various steps may prevent heart disease through the prevention of cardiac hypertrophy, but may also have other consequences. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014430
Subclass_of: Disease Pathway
Synonym: Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
Tree Number: T4.3.8
database_cross_reference: NCI:C39011
database_cross_reference: NCI_BioC:C39011

Dilated Cardiomyopathy Pathway
type: Class
subclass of: Disease Pathway
definition: Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac death from ventricular arrhythmia. Genetically inherited forms of DCM ("familial" DCM) have been identified in 25-35% of patients presenting with this disease, and the inherited gene defects are an important cause of "familial" DCM. The pathophysiology may be separated into two categories: defects in force generation and defects in force transmission. In cases where an underlying pathology cannot be identified, the patient is diagnosed with an "idiopathic" DCM. Current hypotheses regarding causes of "idiopathic" DCM focus on chronic viral myocarditis and/or on autoimmune abnormalities. Viral myocarditis may progress to an autoimmune phase and then to progressive cardiac dilatation. Antibodies to the beta1-adrenergic receptor (beta1AR), which are detected in a substantial number of patients with "idiopathic" DCM, may increase the concentration of intracellular cAMP and intracellular Ca2+, a condition often leading to a transient hyper-performance of the heart followed by depressed heart function and heart failure.
PMOID: PMO:00014431
Subclass_of: Disease Pathway
Synonym: DCM Pathway
Synonym: Dilated cardiomyopathy
Tree Number: T4.3.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91470
database_cross_reference: NCI_KEGG:C91470

Graft-Versus-Host Disease Pathway
type: Class
subclass of: Disease Pathway
definition: Graft-versus-host disease (GVHD) pathophysiology can be summerized in a three-step process. During step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues and induction of inflammatory cytokines [tumour necrosis factor (TNF-alpha) and interleukin (IL-1)] secretion. Increased expression of major histocompatibility complex (MHC) antigens and adhesion molecules leads to enhancement of the recognition of host MHC and/or minor histocompatibility antigens by mature donor T cells.
PMOID: PMO:00014432
Subclass_of: Disease Pathway
Synonym: GVHD Pathway
Synonym: Graft-versus-host disease
Tree Number: T4.3.10
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91481
database_cross_reference: NCI_KEGG:C91481

Hypertrophic Cardiomyopathy Pathway
type: Class
subclass of: Disease Pathway
definition: Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological features of myocyte hypertrophy, myofibrillar disarray, and interstitial fibrosis. HCM is one of the most common inherited cardiac disorders, with a prevalence in young adults of 1 in 500. Hundreds of mutations in 11 genes that encode protein constituents of the sarcomere have been identified in HCM. These mutations increase the Ca2+ sensitivity of cardiac myofilaments. Increased myofilament Ca2+ sensitivity is expected to increase the ATP utilization by actomyosin at submaximal Ca2+ concentrations, which might cause an imbalance in energy supply and demand in the heart under severe stress. The inefficient use of ATP suggests that an inability to maintain normal ATP levels could be the central abnormality. This theory might be supported by the discovery of the role of a mutant PRKAG2 gene in HCM, which in active form acts as a central sensing mechanism protecting cells from depletion of ATP supplies. The increase in the myofilament Ca2+ sensitivity well account for the diastolic dysfunction of model animals as well as human patients of HCM. It has been widely proposed that left ventricular hypertrophy is not a primary manifestation but develops as compensatory response to sarcomere dysfunction.
PMOID: PMO:00014433
Subclass_of: Disease Pathway
Synonym: HCM Pathway
Synonym: Hypertrophic cardiomyopathy (HCM)
Tree Number: T4.3.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91484
database_cross_reference: NCI_KEGG:C91484

Hypoxia Pathway
type: Class
subclass of: Disease Pathway
definition: Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, hypoxia does not induce p53-dependent cell cycle arrest, suggesting that p53 activity is differentially regulated by these two stresses. Hypoxia induces p53 protein accumulation, but in contrast to DNA damage, hypoxia fails to induce endogenous downstream p53 effector mRNAs and proteins, such as p21, Bax, CIP1, WAF1, etc. Hypoxia does not inhibit the induction of p53 target genes by ionizing radiation, indicating that p53-dependent transactivation requires a DNA damage-inducible signal that is lacking under hypoxic treatment alone. The phosphatidylinositol 3-OH-kinase-Akt pathway inhibits p53-mediated transcription and apoptosis. Mdm2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 and serves as a good substrate for Akt. Mdm-2 targets the p53 tumor suppressor for ubiquitin-dependent degradation by the proteasome, but, in addition, the p53 transcription factor induces Mdm-2, thus, establishing a feedback loop. Hypoxia or DNA damage by abrogating binding of HIF-1 with VHL and p53 with Mdm-2, respectively, leads to stabilization and accumulation of transcriptionally active HIF-1 and p53. At the molecular level, DNA damage induces the interaction of p53 with the transcriptional activator p300 as well as with the transcriptional corepressor mSin3A. In contrast, hypoxia primarily induces an interaction of p53 with mSin3A, but not with p300. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014434
Subclass_of: Disease Pathway
Synonym: Hypoxia and p53 in the Cardiovascular system
Tree Number: T4.3.12
database_cross_reference: NCI:C39179
database_cross_reference: NCI_BioC:C39179

Infectious Disease Pathway
type: Class
subclass of: Disease Pathway
definition: A sequence of biological or biochemical events that are the result of contracting an infection.
PMOID: PMO:00014435
Subclass_of: Disease Pathway
Synonym: Infectious Disease
Tree Number: T4.3.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39738
database_cross_reference: NCI_KEGG:C39738

Amoebiasis Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Entamoeba histolytica, an extracellular protozoan parasite, is a human pathogen that invades the intestinal epithelium. Infection occurs upon ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteinases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection, like amoebic liver abscess, by evading the immune response.
PMOID: PMO:00014436
Subclass_of: Infectious Disease Pathway
Synonym: Amoebiasis
Synonym: E. histolytica Infection Pathway
Synonym: Entamoeba histolytica Infection Pathway
Tree Number: T4.3.13.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91808
database_cross_reference: NCI_KEGG:C91808

Anthrax Toxin Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: One of the key causes of anthrax virulence is the action of three specific factors produced by the bacterium Bacillus anthracis. Even with successful antibiotic treatment, anthrax toxins can remain in the circulation and cause lethality. The toxins produced by anthrax bacteria are lethal factor (LF), protective antigen (PA) and edema factor (EF). The entry of toxin into cells begins with the recognition of a cellular receptor in the plasma membrane by PA. Proteolytic cleavage of cell-bound PA creates a smaller fragment that then multimerizes into a pore-like structure in the plasma membrane. The LF and EF proteins bind to the PA pre-pore, followed by internalization of the entire structure through receptor-mediated endocytosis. In the endosomal compartment, the acidic pH causes a conformational change that inserts PA fragments and releases LF and EF into the cytoplasm. In the cytoplasm, LF acts as a protease that cleaves MAP kinase kinase (MAPKK 1 and MAPKK 2), inhibiting pathways that rely on this kinase family and causing cell death. Edema factor is an adenylate cyclase that inhibits the immune response, including phagocytosis by macrophages. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014437
Subclass_of: Infectious Disease Pathway
Synonym: Anthrax Toxin Mechanism of Action
Tree Number: T4.3.13.2
database_cross_reference: NCI:C38986
database_cross_reference: NCI_BioC:C38986

Bacterial Invasion of Epithelial Cell Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Many pathogenic bacteria can invade phagocytic and non-phagocytic cells, colonize them intracellularly, and then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signaling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
PMOID: PMO:00014438
Subclass_of: Infectious Disease Pathway
Synonym: Bacterial invasion of epithelial cells
Tree Number: T4.3.13.3
database_cross_reference: NCI:C91804
database_cross_reference: NCI_KEGG:C91804

Botulin Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: The neuromuscular junction communicates action potentials from motor neurons across a synapse to skeletal muscle. When an action impulse arrives at the neuromuscular junction, the entry of calcium through voltage-gated calcium channels causes synaptic vesicles to fuse with the presynaptic plasma membrane and release the neurotransmitter acetylcholine into the synaptic cleft. Acetylcholine diffuses across the cleft and binds to muscle acetylcholine receptors, causing depolarization and an action potential that travels throughout the length of the muscle cell triggering muscle contraction. The release of neurotransmitter at the synapse involves the fusion of synaptic vesicles with the neuronal plasma membrane and requires several proteins that act together to form a synaptic fusion complex. These proteins, collectively called SNARE proteins, include SNAP-25, syntaxin, and synaptobrevin. Homologs of these proteins are also involved in membrane fusion in other aspects of vesicle trafficking. Synaptobrevin (also called VAMP2) is localized at the synaptic vesicle membrane, while SNAP-25 and syntaxin are associated with the plasma membrane. Calcium release causes the formation of a complex, bringing the synaptic vesicle in close proximity with the plasma membrane and allowing fusion of the membranes. Biological toxins often disrupt nervous function, particularly the action of motor neurons. Botulinum toxin, synthesized by the bacteria Clostridium botulinum, is one of the most potent toxins known and acts by blocking neurotransmitter release at the neuromuscular junction. Botulinum toxin is a protein composed of two subunits joined by a disulfide bond, a 100 kD heavy subunit and a 50 kD light subunit that is a protease. There are seven serotypes of botulinum with distinct toxins. Tetanus toxin is similar in structure and in mechanism of action to botulinum toxin. The toxins can be absorbed in the intestine to travel in the blood to its site of action, at the neuromuscular j…
PMOID: PMO:00014439
Subclass_of: Infectious Disease Pathway
Synonym: Blockade of Neurotransmitter Relase by Botulinum Toxin
Tree Number: T4.3.13.4
database_cross_reference: NCI:C39007
database_cross_reference: NCI_BioC:C39007

Botulinum Toxin Pathway
type: Class
subclass of: Infectious Disease Pathway
PMOID: PMO:00014440
Subclass_of: Infectious Disease Pathway
Synonym: Effects of Botulinum toxin
Tree Number: T4.3.13.5
database_cross_reference: NCI:C91578
database_cross_reference: NCI_PID:C91578

Cellular Anthrax Toxin Pathway
type: Class
subclass of: Infectious Disease Pathway
PMOID: PMO:00014441
Subclass_of: Infectious Disease Pathway
Synonym: Cellular roles of Anthrax toxin
Tree Number: T4.3.13.6
database_cross_reference: NCI:C91562
database_cross_reference: NCI_PID:C91562

Chagas Disease Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed.
PMOID: PMO:00014442
Subclass_of: Infectious Disease Pathway
Synonym: Chagas disease
Synonym: Chagas disease (American trypanosomiasis)
Synonym: T. cruzi Infection Pathway
Synonym: Trypanosoma cruzi Infection Pathway
Tree Number: T4.3.13.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91525
database_cross_reference: NCI_KEGG:C91525

Epithelial Cell Signaling Pathway in Helicobacter pylori Infection
type: Class
subclass of: Infectious Disease Pathway
definition: Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA).
PMOID: PMO:00014443
Subclass_of: Infectious Disease Pathway
Synonym: Epithelial cell signaling in Helicobacter pylori infection
Synonym: H. pylori Virulence Factor Pathway
Tree Number: T4.3.13.8
database_cross_reference: NCI:C91527
database_cross_reference: NCI_KEGG:C91527

HBx Signaling Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Hepatitis B is a small DNA virus that contains only 4 open reading frames in its genome. Three of these ORFs have been identified as the envelope, capsid and polymerase genes, while the function of the fourth has remained unknown until recently. The fourth reading frame has been called the X gene and produces HBx protein that is essential for viral replication in liver cells and acts broadly to activate a variety of transcription factors. One hypothesis of HBx activity has been that it enters the nucleus to act as a transcriptional regulator. One piece of evidence supporting this mechanism of HBx action is that HBx interacts with the transcription factor CREB and increases its DNA-binding activity. This mechanism does not explain all of the effects of HBx however. Another hypothesis for the HBx mechanism of action is that HBx increases calcium release into the cytoplasm. This mechanism of action is consistent with the variety of transcription factors and kinases affected by HBx since calcium signaling affects many different signaling pathways. HBx does not appear to interact directly with Ras or protein kinases but does appear to activate the calcium activate protein kinase Pyk2. A dominant negative form of Pyk2 blocks HBx activity and the involvement of calcium in HBx activation of Pyk2 is indicated by the action of several molecular probes that alter cytosolic calcium signaling. BAPTA-AM chelates cytosolic and blocks HBx action. Cyclosporin A blocks mitochondrial calcium signaling and also blocked HBx signaling. CGP37157 is a compound that blocks the mitochondrial sodium calcium pump and also blocks hepatitis B viral replication, indicating that mitochondrial calcium signaling is the target of HBx function. Compounds that elevate cytoplasmic calcium levels (valinomycin and thapsigargin) increase the rate of replication of viruses that lack HBx, further supporting the role of HBx as an inducer of intracellular calcium signaling. The mechanism by which HBx causes ca…
PMOID: PMO:00014444
Subclass_of: Infectious Disease Pathway
Synonym: Calcium Signaling by HBx of Hepatitis B virus
Tree Number: T4.3.13.9
database_cross_reference: NCI:C39100
database_cross_reference: NCI_BioC:C39100

HIV-1 Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Cells have many defenses against viral infection, including intracellular proteins that interfere with viral replication. Just as mammals have evolved defenses against viruses, viruses have evolved countermeasures to defeat cellular defenses. Vif is a viral gene produced by the HIV virus whose molecular function has remained unclear, but many aspects of its behavior have been revealed. Vif proteins are required for the production of infectious viral particles in many cells, acting to repress an intracellular T cell antiviral defense. Vif interacts with viral RNA and may help package viral genomic RNA to form mature virus. Some Vif is also found packaged in virion particles and multimerization of Vif appears to play a role in its activity. CEM15 is a cellular protein that provides an intracellular defense against HIV replication in T cells by acting against Vif. Viruses lacking the Vif gene are only able to replicate in cells lacking CEM15 and expressing CEM15 in cells is sufficient to prevent HIV infection. Although this research partially clarifies the function of Vif in HIV replication, many questions remain to be answered. CEM15 may or may not interact directly with Vif to block its function. Vif has been shown to bind to HIV genomic RNA and CEM15 has homology to cytidine deaminases, enzymes that edit RNA. This homology suggests that CEM15 may itself have an enzyme activity that modifies HIV RNA to render virus non-infectious. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014445
Subclass_of: Infectious Disease Pathway
Synonym: HIV-1 defeats host-mediated resistance by CEM15
Tree Number: T4.3.13.10
database_cross_reference: NCI:C39265
database_cross_reference: NCI_BioC:C39265

HIV-1 Nef
type: Class
subclass of: Infectious Disease Pathway
PMOID: PMO:00014446
Subclass_of: Infectious Disease Pathway
Synonym: HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha
Synonym: HIV-1 Nef: Negative effector of Fas and TNF-alpha
Tree Number: T4.3.13.11
database_cross_reference: NCI:C91612
database_cross_reference: NCI_PID:C91612

Human Cytomegalovirus Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: To replicate in host cell, viruses commandeer cellular signaling pathways. Cytomegalovirus (CMV) is a DNA virus that is widespread in the population but usually causes disease only in immunocompromised individuals and is also a viral cause of birth defects. One of the actions of CMV in the host cell is to stimulate MAP kinase pathways. Both p38 and ERK kinases are activated by CMV infection through activation of map kinase kinases and inhibition of phosphatases. One result of Map kinase activation by CMV is activation of transcription of viral genes, increasing the production of viral gene products. Both p38 and ERK kinases contribute to the activation of viral genes by cellular transcription factors acting through the viral UL4 promoter at upstream and basal transcription elements. Another target of prolonged p38 activation during infection is Rb, contributing to viral replication. Activation of MKK1 and MKK2 leads to Erk1 and Erk2 activation, and phosphorylation of downstream targets. The MEKK1 kinase regulates the immediate early promoter indirectly through downstream kinase signaling and perhaps more directly through activation of NF-kB. Map kinase pathways activated by CMV converge on increased transcription of viral genes and increased replication of the viral genome. Better understanding of the mechanisms involved in the interaction of CMV with cellular signaling machinery will provide improved ways to treat CMV-mediated disease. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014447
Subclass_of: Infectious Disease Pathway
Synonym: Human Cytomegalovirus and Map Kinase Pathways
Tree Number: T4.3.13.12
database_cross_reference: NCI:C39101
database_cross_reference: NCI_BioC:C39101

Leishmaniasis Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and proliferate intracellularly by deactivating the macrophage. Successful infection of Leishmania is achieved by alteration of signaling events in the host cell, leading to enhanced production of the autoinhibitory molecules like TGF-beta and decreased induction of cytokines such as IL12 for protective immunity. Nitric oxide production is also inhibited. In addition, defective expression of major histocompatibility complex (MHC) genes silences subsequent T cell activation mediated by macrophages, resulting in abnormal immune responses.
PMOID: PMO:00014448
Subclass_of: Infectious Disease Pathway
Synonym: Leishmaniasis
Tree Number: T4.3.13.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91491
database_cross_reference: NCI_KEGG:C91491

Malaria Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Plasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop into the merozoite form. Sporozoite invasion of hepatocytes is mediated by parasite surface protein like CSP. Subsequent infection into red blood cells (RBCs) by merozoites causes malaria disease via aberrant cytokine production and sequestration of parasite-infected red blood cells (pRBCs) to host endothelium. Microvasculature sequestration in the brain brings about cerebral malaria that can result in death or persisting neurological impairment. PfEMP1 has been suggested as the key adhesive molecule of pRBCs.
PMOID: PMO:00014449
Subclass_of: Infectious Disease Pathway
Synonym: Malaria
Synonym: Plasmodium Infection Pathway
Synonym: Plasmodium sp. Infection Pathway
Tree Number: T4.3.13.14
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91807
database_cross_reference: NCI_KEGG:C91807

NFKB Activation Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: The role of Hemophilus influenzae in ear infections and chronic obstructive pulmonary disease includes the induction of an inflammatory response through activation of the transcription factor NF-kB. In addition to activation of inflammatory cytokine genes like IL-1 and TNF, H. influenzae activates TLR2 expression and genes involved in mucus production. Hemophilus influenzae activates NF-kB by multiple mechanisms, starting with activation of the Toll-like receptor 2 (TLR2) by the p16 protein in the H. influenzae outer membrane. TLR2 plays a key role in innate immune responses and is expressed in high levels in lymphoid cells as well as low levels in epithelial cells. The role of TLR2 was supported by blocking NF-kB activation with a dominant negative TLR2 and increasing it with transfection of a normal TLR2 gene. TLR2 in turn activates TAK1, which activates two divergent signaling pathways. One of these pathways leads to IkB kinase activation, IkB phosphorylation, and degradation, releasing the NF-kB heterodimer to translocate into the nucleus and activate transcription of target genes. In the alternate pathway, TAK1 also activates NF-kB through a Map kinase pathway, activating p38 and NF-kB in a nuclear translocation independent manner. Investigation of the mechanisms of H. influenzae signaling involved in NF-kB activation may provide the information needed to develop better treatments for inflammatory conditions caused by this pathogen. Other pathways modulate the role of NF-kB in H. influenzae pathogenesis. Glucocorticoids, widely used as anti-inflammatory drugs, increase TLR2 activation by H. influenzae through the NIK/I-kB kinase pathway, while they repress the p38 dependent activation of NF-kB. The repression of the p38 pathway by glucocorticoids occurs through activation of the MAP kinase phosphatase-1 (MKP-1) which dephosphorylates and deactivates p38. Another aspect of the inflammatory response to H. influenzae infection is the production of excessive mucus,…
PMOID: PMO:00014450
Subclass_of: Infectious Disease Pathway
Synonym: NFkB activation by Nontypeable Hemophilus influenzae
Tree Number: T4.3.13.15
database_cross_reference: NCI:C39173
database_cross_reference: NCI_BioC:C39173

Pathogenic Escherichia coli Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells.
PMOID: PMO:00014451
Subclass_of: Infectious Disease Pathway
Synonym: Pathogenic E. coli Infection Pathway
Synonym: Pathogenic Escherichia coli infection
Tree Number: T4.3.13.16
database_cross_reference: NCI:C91474
database_cross_reference: NCI_KEGG:C91474

Salmonella Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Pathogenic Salmonella enter cells such as those of the intestinal epithelium by altering cellular cytoskeletal structure and inducing membrane ruffling of the infected cell. Salmonella is able to alter the cytoskeleton and membrane through the action of secreted bacterial Sip proteins, SopE, SopB, and SptP that are inserted into the cytosol of the infected cell. Sip proteins encoded by Salmonella are required for the action of SopE and for the invasion of epithelial cells. SipA stabilizes actin filaments, inducing membrane ruffling and perhaps focusing membrane changes where bacteria are localized to allow their entry. SipC produces a similar effect on actin filaments and cytoskeletal structure. SopE acts as an exchange factor on Rac1 and Cdc42, two GTPases in the Rho family that regulate actin cytoskeleton. The activation of Rac2 and Cdc42 by Salmonella SopE induces changes in cytoskeleton structure that allow bacterial entry into the cell. SopB is another salmonella protein that acts as an inositol polyphosphate phosphatase and also stimulates Cdc42 and Rac1. One of the cellular targets of both Cdc42 and Rac1 that affects actin structure is the Arp2/3 complex. Cdc42 and Rac1 activate Wasp, which activates Arp2/3. Activated Arp2/3 induces the formation of actin Y branches, which in combination with changes in actin caused by SipA and SipC help to form lamellipodia, and causes membrane ruffling, leading to entry of Salmonella into the affected cell. After the initial infection, cells quickly return to their normal morphology, a process that depends on the action of the bacterial protein SptP. While SopE acts as an exchange factor, SptP acts as a GTPase activating protein to inactivate Rac1 and Cdc42 once again. This inactivation of the original entry mechanism provides an example of the delicate balance between infectious organisms and their host. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014452
Subclass_of: Infectious Disease Pathway
Synonym: How does salmonella hijack a cell
Tree Number: T4.3.13.17
database_cross_reference: NCI:C39227
database_cross_reference: NCI_BioC:C39227

SARS Coronavirus Protease Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Severe Acute Respiratory Syndrome (SARS) has affected thousands of individuals, causing fever, and pneumonia with a mortality rate estimated at 10-18%. Human coronaviruses cause mild respiratory illness and account for about a third of all cases of the common cold. A novel coronavirus has been identified as the causative agent of SARS and its genome has been sequenced. The enveloped SARS virus contains a large plus strand RNA genome, approximately 30,000 nucleotides. Examination of the SARS coronavirus sequences reveals that the rep gene covers over 20,000 nucleotides and encodes two overlapping polyproteins cleaved by viral proteases into smaller protein products. Translation of the longer polyprotein encoded by the rep gene requires a ribosomal frameshift. Other viral genes are predicted to encode the transmembrane spike protein S involved in viral fusion with host cells, the envelope protein E, the membrane protein M and the nucleocapsid protein N that binds to the RNA genome as well as several additional open reading frames with unknown functions. Viral entry into the cell is followed by translation of the viral rep gene, which codes for a viral protease within the polyprotein, Mpro or 3CLpro. The SARS 3CLpro has also been verified in vitro to cleave after the Gln residue at Leu-Gln-(Ser, Ala, Gly). Polypeptides released from the polyproteins by the main viral protease Mpro or 3CLpro include the viral polymerase and a protease. Both products are essential for viral replication and transcription. Structural crystals of a porcine coronavirus protease with a transition state inhibitor suggest that inhibitors of the distantly related rhinovirus protease like the drug AG7088 may be modified to produce drugs that block the SARS protease and viral replication. Blocking entry of the SARS virus into cells, involving recognition of cellular receptors by the S spike protein, may provide another strategy for the development of drugs to treat SARS. (This definition may be ou…
PMOID: PMO:00014453
Subclass_of: Infectious Disease Pathway
Synonym: SARS Coronavirus Protease
Tree Number: T4.3.13.18
database_cross_reference: NCI:C39229
database_cross_reference: NCI_BioC:C39229

Shigellosis Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestinal epithelium by exploiting epithelial-cell functions and circumventing the host innate immune response. During basolateral entry into the host-cell cytoplasm, Shigella deliver a subset of effectors into the host cells through the type III secretion system. The effectors induce membrane ruffling through the stimulation of the Rac1-WAVE-Arp2/3 pathway, enabling bacterial entry into the epithelial cells. During multiplication within the cells, Shigella secrete another subset of effectors. VirG induces actin polymerization at one pole of the bacteria, allowing the bacteria to spread intracellularly and to infect adjacent cells. OspF, OspG and IpaH(9.8) downregulate the production of proinflammatory cytokines such as IL-8, helping bacteria circumvent the innate immune response.
PMOID: PMO:00014454
Subclass_of: Infectious Disease Pathway
Synonym: Shigella Infection Pathway
Synonym: Shigellosis
Tree Number: T4.3.13.19
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91806
database_cross_reference: NCI_KEGG:C91806

Vibrio cholerae Infection Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Cholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, the entire CTX complex is carried from plasma membrane (PM) to endoplasmic reticulum (ER). In the ER, the A-chain (CTXA) is recognized by protein disulfide isomerase (PDI), unfolded, and delivered to the membrane where the membrane-associated ER-oxidase, Ero1, oxidizes PDI to release the CTXA into the protein-conducting channel, Sec61. CTXA is then retro-translocated to the cytosol and induces water and electrolyte secretion by increasing cAMP levels via adenylate cyclase (AC) to exert toxicity.
PMOID: PMO:00014455
Subclass_of: Infectious Disease Pathway
Synonym: V. cholera Infection Pathway
Synonym: Vibrio cholerae infection
Tree Number: T4.3.13.20
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91464
database_cross_reference: NCI_KEGG:C91464

Viral Myocarditis Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is still considered the dominant etiological agent. Myocarditis may be caused by direct cytopathic effects of virus, a pathologic immune response to persistent virus, or autoimmunity triggered by the viral infection. The virus enters the myocyte through internalization of the coxsackie-adenoviral receptor (CAR) and its coreceptor, decay-accelerating factor (DAF). Viral proteases cleave various proteins in the host cell. One example is viral protease 2A, which cleaves eukaryote initiation factor 4G (eIF4G) and the dystrophin protein, resulting in a complete shutdown of cap-dependent RNA translation and cytoskeletal destruction in infected cardiomyocytes, respectively. CVB3 also cleaves the member of the Bcl-2 family Bid, leading to apoptosis. CVB3 infection also induces the cleavage of cyclin D protein through a proteasome-dependent pathway, leading to the host cell-growth arrest. Viral infection and necrosis of myocytes may lead to the release of intracellular antigens, resulting in activation of self-reactive T cells. CVB infection is a significant cause of dilated cardiomyopathy (DCM) as well as myocarditis. Epidemiologically, myocarditis underlies a significant portion of patients with DCM.
PMOID: PMO:00014456
Subclass_of: Infectious Disease Pathway
Synonym: Viral myocarditis
Tree Number: T4.3.13.21
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91441
database_cross_reference: NCI_KEGG:C91441

West Nile Virus Pathway
type: Class
subclass of: Infectious Disease Pathway
definition: A description of the life cycle of the West Nile virus.
PMOID: PMO:00014457
Subclass_of: Infectious Disease Pathway
Synonym: West Nile Virus
Tree Number: T4.3.13.22
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39271
database_cross_reference: NCI_BioC:C39271

Insulin Resistance Pathway
type: Class
subclass of: Disease Pathway
definition: The insulin resistance of type II diabetes appears to be caused in part by the presence of high levels of lipids in cells such as skeletal muscle where this would not normally be found. The presence of excess lipid stores in skeletal muscle cells interferes with energy metabolism, impairing glucose oxidation and insulin response. Skeletal muscle is one of the primary glucose-consuming tissues, giving it a central role in insulin resistance. The increased risk of diabetes associated with obesity may be caused by increased lipid deposits in skeletal muscle and liver, creating insulin resistance. Leptin is a peptide hormone secreted by adipose tissue that has been associated with many processes. One of the target tissues of leptin is the hypothalamus where it can act to regulate feeding behavior and metabolism. Another leptin target is skeletal muscle. Activation of leptin signaling in skeletal muscle activates the AMP-activated protein kinase (AMP-kinase), known to play a key role in signaling in response to nutrients throughout evolution. AMPK phosphorylates and inactivates the enzyme ACC, acetyl-CoA carboxylase. ACC catalyzes the production of malonyl-CoA from acetyl-CoA. Malonyl-CoA in turn is an inhibitor of the import of fatty acids into mitochondria by carnitine palmitoyltransferase I for oxidation and energy production. In the presence of leptin, AMPK is activated, ACC is inhibited, and malonyl-CoA levels fall, increasing the oxidation of fatty acids and reducing the lipid content of cells. The reduced lipid content in skeletal muscle allows insulin signaling and glucose consumption to return to their normal levels, reducing insulin resistance. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014458
Subclass_of: Disease Pathway
Synonym: Reversal of Insulin Resistance by Leptin
Tree Number: T4.3.14
database_cross_reference: NCI:C39139
database_cross_reference: NCI_BioC:C39139

LDL Pathway
type: Class
subclass of: Disease Pathway
definition: Low-density lipoprotein (LDL) is a plasma lipoprotein particle whose lipid component includes cholesterol and triglycerides and is commonly referred to as bad cholesterol due to its role promoting atherogenic heart disease. LDL in the plasma originates from very-low density lipoprotein (vLDL) produced by the liver with the apoprotein B-100. vLDL is converted to LDL by the action of lipoprotein lipase, an enzyme that hydrolyzes triglycerides in vLDL, removing them from the vLDL particle and releasing free fatty acids. The removal of triglycerides from vLDL by lipoprotein lipase leaves a greater proportion of cholesterol, increasing the density of the particle and changing it to LDL. Atherogenic heart disease involves the formation of plaques in arterial walls that narrow the arterial passage, restricting blood flow and increasing the risk of occlusion of blood flow by a myocardial infarction. One of the first steps in the development of atherogenic heart disease is the passage of LDL out of the arterial lumen and into the arterial wall. Once there, the lipids in LDL are chemically modified and oxidized. Oxidized LDL stimulates inflammatory signaling by neighboring endothelial cells, releasing chemokines and cytokines such as M-CSF and MCP-1 and recruiting monocytes into the arterial wall. Once there, monocytes differentiate into macrophages and internalize modified LDL. These macrophages continue to internalize LDL, becoming enlarged and full of lipid. These cells accumulate in tissue and are transformed into foam cells, dying and forming part of the atherogenic plaque. Therapeutic intervention in atherogenic heart disease focuses first on lowering plasma LDL levels through diet and medication. The statins are drugs commonly used to block cholesterol production and increase the expression of the LDL receptor by the liver, removing LDL from circulation. Blocking LDL oxidation may also protect against atherogenesis, and may be the mechanism by which antioxidants such a…
PMOID: PMO:00014459
Subclass_of: Disease Pathway
Synonym: Low-density lipoprotein (LDL) pathway during atherogenesis
Tree Number: T4.3.15
database_cross_reference: NCI:C39137
database_cross_reference: NCI_BioC:C39137

Maturity Onset Diabetes of the Young Pathway
type: Class
subclass of: Disease Pathway
definition: About 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MODY).
PMOID: PMO:00014460
Subclass_of: Disease Pathway
Synonym: MODY
Synonym: MODY Pathway
Synonym: Maturity onset diabetes of the young
Synonym: Type II Diabetes Mellitus in Young Patients Pathway
Tree Number: T4.3.16
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91449
database_cross_reference: NCI_KEGG:C91449

Metabolic Syndrome Pathway
type: Class
subclass of: Disease Pathway
definition: Obesity is associated with many adverse health effects, including an increased risk of diabetes and heart disease. The combined condition of obesity, diabetes, and heart disease is sometimes referred to as the metabolic syndrome. One of the factors that best correlates obesity with the rest of the metabolic syndrome is not overall body mass, but the distribution of adipose tissue in the abdominal region, visceral obesity. Glucocorticoids have been associated as a risk factor for the metabolic syndrome, but most obese individuals have normal levels of circulating corticosteroids. Active corticosteroids such as cortisol and corticosterone activate the glucocorticoid receptor, a nuclear hormone receptor and transcription factor. Obese individuals have elevated levels in adipose tissue of a key enzyme in glucocorticoid metabolism, 11beta hydroxysteroid dehydrogenase type 1 (11betaHSD-1). 11betaHSD-1 interconverts inactive corticosteroids and the active form. When present in cells, 11betaHSD-1 can convert inactive corticosteroids from the blood to create locally high concentrations in a tissue such as adipose tissue. When activated in adipose tissue, GR increases the level of visceral fat, induces insulin resistance and dyslipidemias that increase the risk of heart disease. The mechanisms by which GR might induce the various aspects of the metabolic syndrome are a key area of research. One of the genes activated by GR is lipoprotein lipase. When GR is activated in visceral adipose tissue, it will increase the expression of lipoprotein lipase (LPL). This enzyme hydrolyzes triglycerides in plasma, releasing free fatty acids into tissues, where they can be reassembled into triglycerides. In visceral adipose, this GR-driven overexpression of lipoprotein lipase will result in the increased deposits of visceral fat that are observed. Genes thought to be involved in insulin resistance also appear to be affected by altered 11betaHSD-1 corticosteroid metabolism in visceral fat. T…
PMOID: PMO:00014461
Subclass_of: Disease Pathway
Synonym: Visceral Fat Deposits and the Metabolic Syndrome
Tree Number: T4.3.17
database_cross_reference: NCI:C39268
database_cross_reference: NCI_BioC:C39268

MTA3 Pathway
type: Class
subclass of: Disease Pathway
definition: Approximately 30% of breast carcinomas lack ER expression. Presumably, these breast cancers become estrogen independent through genetic alterations that bypass the requirement for ER-dependent stimulation of cell proliferation. As such, estrogen receptor is a key regulator of proliferation and differentiation in mammary epithelia and represents a crucial prognostic indicator and therapeutic target in breast cancer. Mechanistically, estrogen receptor induces changes in gene expression through direct gene activation of a number of genes (e.g., cathepsin D, HSP27, alpha-tubulin, glyceraldehyde-3-phosphatase, Pdzk1, Greb) and also through the biological functions of target loci. The product of human MTA3 has been identified as an estrogen-dependent component of the Mi-2/NuRD transcriptional corepressor in breast epithelial cells and demonstrates that MTA3 constitutes a key component of an estrogen-dependent pathway regulating growth and differentiation. The absence of estrogen receptor or of MTA3 leads to aberrant expression of the transcriptional repressor Snail, a master regulator of epithelial to mesenchymal transitions. Aberrant Snail expression results in loss of expression of the cell adhesion molecule E-cadherin, an event associated with changes in epithelial architecture and invasive growth. MTA3 is the mechanistic link between estrogen receptor status and invasive growth of breast cancers. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014462
Subclass_of: Disease Pathway
Synonym: Downregulated of MTA-3 in ER-negative Breast Tumors
Tree Number: T4.3.18
database_cross_reference: NCI:C39158
database_cross_reference: NCI_BioC:C39158

Neurodegenerative Disorders Pathway
type: Class
subclass of: Disease Pathway
PMOID: PMO:00014463
Subclass_of: Disease Pathway
Synonym: Neurodegenerative Disorders
Tree Number: T4.3.19
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39737
database_cross_reference: NCI_KEGG:C39737

Alzheimer's Disease Pathway BioCarta
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: Cyclin-dependent kinase 5 (cdk5), a multi-functional kinase, and its neuron-specific activator p35 are required for neurite outgrowth and cortical lamination. Proteolytic cleavage of p35 produces p25, which accumulates in the brains of patients with Alzheimer's disease. Conversion of p35 to p25 causes prolonged activation and mislocalization of cdk5 and the hyperphosphorylates tau, leading to the formation of paired helical filaments and promotion of apoptosis. In cultured primary cortical neurons, excitotoxins, hypoxic stress and calcium influx induce the production of p25. In fresh brain lysates, addition of calcium can stimulate cleavage of p35 to p25. Specific inhibitors of calpain1 effectively inhibit the calcium-induced cleavage of p35. In vitro, calpain1 directly cleaves p35 to release a fragment with relative molecular mass 25,000. Application of the amyloid beta-peptide A beta induces the conversion of p35 to p25 in primary cortical neurons. Inhibition of cdk5 or calpain activity reduces cell death in A beta-treated cortical neurons. These observations indicate that cleavage of p35 to p25 by calpain may be involved in the pathogenesis of Alzheimer's disease. GSK3B also phosphorylates tau but does not induce hyperphosphorylation in response to calpain activating stimuli. Additionally, down-regulation or inhibition of PP2A increases the hyper-phosphorylation of tau. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014464
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Deregulation of CDK5 in Alzheimers Disease
Tree Number: T4.3.19.1
database_cross_reference: NCI:C39177
database_cross_reference: NCI_BioC:C39177

Alzheimer's Disease Pathway KEGG
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specifically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
PMOID: PMO:00014465
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Alzheimer's Disease
Tree Number: T4.3.19.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38778
database_cross_reference: NCI_KEGG:C38778

Amyloid Beta-Peptide Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: Alzheimer's disease is associated with dense aggregations of proteins in the brain called amyloid plaques that contain beta-amyloid fragments as a primary component. If the development of amyloid plaques is responsible for neurodegeneration in Alzheimer's disease, reduction of beta-amyloid formation may prevent the development and progression of disease symptoms. Beta-amyloid fragments are derived from proteolytic processing of amyloid precursor protein (APP) in neurons, and the subsequent release of fragments into the extracellular space. APP in the ER is cleaved at residue 17 by alpha-secretase protease activity encoded by ADAM-10 and TACE. Beta-secretase activity, recently identified as BACE, cleaves in the N-terminus of the beta-amyloid fragment. Gamma-secretase cuts APP within the transmembrane domain at amino acids 40 and 42, releasing the beta-amyloid fragment containing residues 1-40/42 as well as shorter products such as p3 (residues 17-40/42) that requires alpha-secretase cleavage. The gamma-secretase activity requires the transmembrane protein Presenilin-1 that is itself cleaved into an N-terminal and C-terminal fragment that both are required for gamma-secretase activity. Mutations in presenilin-1 have been genetically associated with familial forms of Alzheimer's disease, further supporting the role of APP processing the development of the disease. Inhibition of the beta- or gamma-secretases may provide a mechanism to treat this disease. Other mechanisms may include altering degradation of beta-amyloid, and the use of vaccines against beta-amyloid to remove aggregates. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014466
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Generation of amyloid b-peptide by PS1
Tree Number: T4.3.19.3
database_cross_reference: NCI:C38988
database_cross_reference: NCI_BioC:C38988

Amyotrophic Lateral Sclerosis Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord, leading to paralysis of voluntary muscles. Mutant superoxide dismutase 1 (SOD1), as seen in some familial amyotrophic lateral sclerosis (FALS) cases, may be toxic because it is unstable, forming aggregates in the motor neuron cytoplasm, axoplasm and mitochondria. Within mitochondria, mutant SOD1 may interfere with the anti-apoptotic function of Bcl-2, affect mitochondrial import by interfering with the translocation machinery (TOM/TIM), and generate toxic free radicals (ROS) via aberrant superoxide chemistry. These changes may then result in abnormal mitochondrial energy metabolism, Ca2+ handling, and release of pro-apoptotic factors. Reactive oxygen species (ROS), produced within mitochondria, inhibit the function of EAAT2, the main glial glutamate transporter protein, responsible for most of the reuptake of synaptically released glutamate. Glutamate excess causes neurotoxicity by increasing intracellular calcium, which enhances oxidative stress and mitochondrial damage. Mutant SOD1 can also trigger oxidative reactions by various means including by increasing levels of peroxynitrite, which can then cause damage through the formation of hydroxyl radicals or via nitration of tyrosine residues on proteins. Nitration may target neurofilament proteins, disrupting their phosphorylation and affecting axonal transport. Collectively, these mechanisms (or a combination thereof) are predicted to disturb cellular homeostasis (within glial and/or motor neurons), ultimately triggering motor neuron death.
PMOID: PMO:00014467
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Amyotrophic Lateral Sclerosis (ALS)
Tree Number: T4.3.19.4
database_cross_reference: NCI:C38782
database_cross_reference: NCI_KEGG:C38782

Huntington's Disease Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). HD is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (Htt). Mutant Htt (mHtt) has effects both in the cytoplasm and in the nucleus. In the cytoplasm, full-length mHtt can interfere with BDNF vesicular transport on microtubules. This mutant protein also may lead to abnormal endocytosis and secretion in neurons, because normal Htt form a complex with the proteins Hip1, clathrin and AP2 that are involved in endocytosis. In addition, mHtt affects Ca2+ signaling by sensitizing InsP3R1 to activation by InsP3, stimulating NR2B/NR1 NMDAR activity, and destabilizing mitochondrial Ca2+ handling. As a result, stimulation of glutamate receptors leads to supranormal Ca2+ responses in HD MSN and mitochondrial Ca2+ overload. The mHtt translocates to the nucleus, where it forms intranuclear inclusions, though they are not primarily responsible for toxicity. Nuclear toxicity is believed to be caused by interference with gene transcription, leading to loss of transcription of neuroprotective molecules such as BDNF. While mHtt binds to p53 and upregulates levels of nuclear p53 as well as p53 transcriptional activity. Augmented p53 mediates mitochondrial dysfunction.
PMOID: PMO:00014468
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Huntington's Disease
Tree Number: T4.3.19.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38825
database_cross_reference: NCI_KEGG:C38825

Inhibition of Huntington's Disease Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: Huntington's disease is a neurodegenerative condition caused by a dominant mutation in a gene encoding a protein now called huntingtin. Large polyglutamine repeats in the huntingtin protein are the genetic defect responsible for this condition, caused by expansion of a three-base pair repeat in the gene. Similar expansions of polyglutamine repeats are also found in other genes involved in neurodegenerative conditions. The polyglutamine repeat makes huntingtin protein insoluble and triggers the formation of protein aggregates. There are a few hypotheses for the connection between these aggregates and the neurodegeneration observed in Huntington's disease. One hypothesis is that mutant huntingtin moves into the nucleus and interferes with transcriptional activation involving the transcriptional coactivator CBP (CREB binding protein) and other coactivators. CBP interacts with transcriptional regulatory factors and with the basal transcriptional machinery to help regulate transcription. CBP is a large protein with multiple domains and in addition to interacting with several different transcription factors also has a histone acetylase enzyme activity. Mutant huntingtin binds to CBP, drawing it into insoluble protein aggregates. Mutant huntingtin also interacts directly with the acetyltransferase domain of CBP, blocking this activity. Activation of CBP acetyltransferase activity by transcriptional regulators results in the acetylation of histones in the promoter and enhancer regions of active genes, contributing to transcriptional activation by making these genes more accessible in chromatin. The lack of CBP in Huntington's affected neurons may lead to transcriptional repression of key genes that in turn leads to neurodegeneration. One potential treatment being tested is the treatment of Huntington's affected individuals with histone deacetylase inhibitors to restore normal acetylation levels and transcription. The repression of transcription may also be involved in other…
PMOID: PMO:00014469
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors
Tree Number: T4.3.19.6
database_cross_reference: NCI:C39110
database_cross_reference: NCI_BioC:C39110

Parkinson's Disease Pathway BioCarta
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examination of these neurons in diseased tissue has revealed the presence of Lewy bodies, dense aggregates that include the protein alpha-synuclein. A genetic basis for most cases of Parkinson's disease has not yet been identified, but mutations in alpha-synuclein have been associated with at least one rare form of the disease, and mutations in another protein, the parkin gene, are associated with another inherited form of Parkinson's disease. Parkin is found in Lewy bodies along with alpha-synuclein and the parkin protein is an enzyme, an E3 ubiquitin ligase. This ligase tags specific proteins in normal cells with ubiquitin, targeting them for destruction in the proteasome. One of the proteins that parkin normally targets for destruction is a specific O-glycosylated form of alpha-synuclein. Failure of parkin-mediated degradation of alpha-synuclein may be a key factor leading to the death of dopaminergic neurons. Another substrate of parkin is a GPCR-like protein called Pael-R that accumulates in the ER of affected cells and may cause neuronal cell death. The involvement of Parkin and alpha-synuclein mutations in genetic forms of Parkinson's suggests that failure of ubiquitination and protein degradation may be causative in other forms of Parkinson's. Questions remaining include the cause of the lack of effective ubiquitination in individuals lacking obvious genetic defects in this pathway and how to use this knowledge of ubiquitination and protein degradation in Parkinson's disease to identify therapeutic strategies. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014470
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease
Tree Number: T4.3.19.7
database_cross_reference: NCI:C39276
database_cross_reference: NCI_BioC:C39276

Parkinson's Disease Pathway KEGG
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL1 (ubiquitin carboxy-terminal hydrolase L1), parkin, DJ1 (a parkin-associated protein involved with oxidative stress), and PINK1 (a putative serine threonine kinase) are known to cause early-onset PD. Mutations or altered expression of these proteins contributes to PD pathogenesis through common mechanisms that result in proteasome dysfunction, mitochondrial impairment, and oxidative stress. Point mutations in alpha-synuclein and the recently described functional duplication of alpha-synuclein lead to excessive intracellular accumulation and protofibril formation. Decrease in the amount of soluble alpha-synuclein tends to increase free cytoplasmic dopamine and the formation of reactive oxygen species (ROS). Indeed, formation of protofibrils or aggregates and Lewy bodies (LBs) diminishes the availability of the physiological forms of alpha-synuclein, favoring an increase in TH (tyrosine hydroxylase) and DAT (dopamine transporter), but diminishes formation of vesicles and neuronal plasticity. Modification of parkin and UCHL1 are associated with the ubiquitin-proteasome system pathway and may increase proteotoxic stress. Mutations in parkin, DJ1, and PINK1 may alter mitochondrial activity, potentially impairing proteasomal function. Environmental toxins such as N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone can cause mitochondrial dysfunction and oxidative stress.
PMOID: PMO:00014471
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Parkinson's Disease
Synonym: Parkinson's Disease Pathway
Tree Number: T4.3.19.8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38845
database_cross_reference: NCI_KEGG:C38845

Prion Disease Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
PMOID: PMO:00014472
Subclass_of: Neurodegenerative Disorders Pathway
Synonym: Prion Disease
Tree Number: T4.3.19.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38853
database_cross_reference: NCI_KEGG:C38853

Prion Pathway
type: Class
subclass of: Neurodegenerative Disorders Pathway
definition: Transmissible spongiform encephalopathy (TSE) is thought to result from the structural conversion of cellular prion protein, PrP(C), into a misfolded oligomeric form, PrP(Sc). PrP is a cell membrane GPI anchored glycoprotein that is expressed in most tissues and in high levels in the nervous system. Some likely cellular functions of PrP are (1) cell protection against oxidative stress, (2) induction of neuronal cell adhesion, neurite extension and maintenance, and (3) neuroprotective signaling through a cAMP/PKA-dependent pathway. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014473
Subclass_of: Neurodegenerative Disorders Pathway
Tree Number: T4.3.19.10
database_cross_reference: NCI:C39201
database_cross_reference: NCI_BioC:C39201

NFAT Pathway
type: Class
subclass of: Disease Pathway
definition: Hypertrophy associated with both hypertension and obstruction to ventricular outflow leads to pathologic cardiac growth and it is associated with increase morbidity and mortality. Symptomatic ventricular disease takes a growing toll on the health of nations. As other cardiovascular diseases such as stroke and myocardial infarction are in decline as causes of mortality, the heart failure problem becomes increasingly urgent. Congenital heart defects occur in 1% of live births and fetal heart malformations are implicated in many pregnancies that end in still-birth or spontaneous abortion. The current paradigm suggests that the heart adapts to excess of hemodynamic loading by compensatory hypertrophy, which under condition of persistent stress, over time evolves into dysfunction and myocardial failure. There is considerable evidence that direct effects of increased mechanical stress are sensed within the ventricular wall and that signal is critical for the generation of growth responses. Despite compelling statistics we still do not understand biochemically why heart defects are so prevalent. A single transcriptional regulator initially associated with the activation of the T-cells (NFATc4) has been shown to link genetic and environmental causes of one class of congenital heart disorders, birth defects involving valve and septum formation. Within the endocardium, specific inductive events appear to activate NF-ATc: it is localized to the nucleus only in endocardial cells that are adjacent to the interface with the cardiac jelly and myocardium, which are thought to give the inductive stimulus to the valve primordia. Treatment with FK506, a specific calcineurin inhibitor, prevents nuclear localization of NF-ATc4. Activated CaMK stimulates calcineurin, which than acts through NF-ATc4 in association with GATA4, to induce hypertrophy. A model for the proposed role of calreticulin in the regulation of cardiac development requires a myogenic signal from extracellular space to …
PMOID: PMO:00014474
Subclass_of: Disease Pathway
Synonym: NFAT and Hypertrophy of the heart (Transcription in the broken heart)
Tree Number: T4.3.20
database_cross_reference: NCI:C39162
database_cross_reference: NCI_BioC:C39162

Primary Immunodeficiency Pathway
type: Class
subclass of: Disease Pathway
definition: Primary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells such as phagocytes and natural killer (NK) cells. These disorders of the immune system cause increased susceptibility to infection, autoimmune disease, and malignancy. Most of PIs are due to genetic defects that affect cell maturation or function at different levels during hematopoiesis. Disruption of the cellular immunity is observed in patients with defects in T cells or both T and B cells. These cellular immunodeficiencies comprise 20% of all PIs. Disorders of humoral immunity affect B-cell differentiation and antibody production. They account for 70% of all PIs.
PMOID: PMO:00014475
Subclass_of: Disease Pathway
Synonym: Primary immunodeficiency
Tree Number: T4.3.21
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91500
database_cross_reference: NCI_KEGG:C91500

Skeletal Muscle Hypertrophy Pathway
type: Class
subclass of: Disease Pathway
definition: Skeletal muscle atrophies with disuse while with increased use and increased load skeletal muscle exhibits hypertrophy, with an increase in the size of existing muscle fibers. One signaling pathway involved in regulating skeletal muscle atrophy and hypertrophy is the AKT/mTOR pathway. The mTOR pathway activity increases in response to muscle activity during hypertrophy and decreases in activity during atrophy. Blocking this pathway genetically or with the mTOR inhibitor rapamycin blocks hypertrophy and genetic activation of the pathway induces hypertrophy. One agent that promotes muscle hypertrophy is the growth factor IGF-1. IGF-1 activates AKT, GSK-3 beta, and mTOR to promote hypertrophy. In contrast, the calcineurin pathway is not involved in hypertrophy and is down-regulated by agents such as IGF-1 that promote hypertrophy. Calcineurin may modulate other aspects of muscle function such as the development of slow muscle fibers through transcriptional regulation. These pathways lead to regulation of protein translation, with increased translation apparently acting as a key regulatory point in skeletal muscle hypertrophy. Agents such as IGF-1 that stimulate skeletal muscle hypertrophy may provide treatments for muscle atrophy and wasting. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014476
Subclass_of: Disease Pathway
Synonym: Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
Tree Number: T4.3.22
database_cross_reference: NCI:C39113
database_cross_reference: NCI_BioC:C39113

Systemic Lupus Erythematosus Pathway
type: Class
subclass of: Disease Pathway
definition: Systemic lupus erythematosus (SLE) is characterized by circulating IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components. Immune complexes comprising autoantibody and self-antigen is deposited particularly in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc-gamma-R-mediated neutrophil and macrophage activation. Activation of complement leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.
PMOID: PMO:00014477
Subclass_of: Disease Pathway
Synonym: SLE Pathway
Synonym: Systemic lupus erythematosus
Tree Number: T4.3.23
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91508
database_cross_reference: NCI_KEGG:C91508

Type I Diabetes Mellitus Pathway
type: Class
subclass of: Disease Pathway
definition: Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).
PMOID: PMO:00014478
Subclass_of: Disease Pathway
Synonym: Type I diabetes mellitus
Tree Number: T4.3.24
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91529
database_cross_reference: NCI_KEGG:C91529

Type II Diabetes Mellitus Pathway
type: Class
subclass of: Disease Pathway
definition: Insulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process.
PMOID: PMO:00014479
Subclass_of: Disease Pathway
Synonym: Type II diabetes mellitus
Tree Number: T4.3.25
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91490
database_cross_reference: NCI_KEGG:C91490

DNA Repair Pathway
type: Class
subclass of: Biochemical Pathway
definition: A sequence of biological or biochemical events that play a role in DNA repair.
PMOID: PMO:00014480
Subclass_of: Biochemical Pathway
Tree Number: T4.4
database_cross_reference: NCI:C39705

BARD1 Pathway
type: Class
subclass of: DNA Repair Pathway
definition: BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and the resulting complex functions as an E3 ubiquitin ligase that catalyzes the synthesis of polyubiquitin chains. UbcH5c and UbcH7 also interact with the BRCA1/BARD1 complex with similar affinity (not shown on this figure). Although the in vivo substrate(s) is not yet known, BRCA1 has been observed to undergo autoubiquitination and is capable of monoubiquitinating histones 2A and 2AX in vitro. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014481
Subclass_of: DNA Repair Pathway
Synonym: BRCA1-dependent Ub-ligase activity
Tree Number: T4.4.1
database_cross_reference: NCI:C38999
database_cross_reference: NCI_BioC:C38999

BARD1 Signaling Pathway
type: Class
subclass of: DNA Repair Pathway
PMOID: PMO:00014482
Subclass_of: DNA Repair Pathway
Synonym: BARD1 signaling events
Tree Number: T4.4.2
database_cross_reference: NCI:C91550
database_cross_reference: NCI_PID:C91550

Base Excision Repair Pathway
type: Class
subclass of: DNA Repair Pathway
definition: Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
PMOID: PMO:00014483
Subclass_of: DNA Repair Pathway
Synonym: Base excision repair
Tree Number: T4.4.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91457
database_cross_reference: NCI_KEGG:C91457

Homologous Recombination Pathway
type: Class
subclass of: DNA Repair Pathway
definition: Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
PMOID: PMO:00014484
Subclass_of: DNA Repair Pathway
Synonym: Homologous recombination
Tree Number: T4.4.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91483
database_cross_reference: NCI_KEGG:C91483

Mismatch Repair Pathway
type: Class
subclass of: DNA Repair Pathway
definition: DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
PMOID: PMO:00014485
Subclass_of: DNA Repair Pathway
Synonym: DNA Mismatch Repair Pathway
Synonym: Mismatch repair
Tree Number: T4.4.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91471
database_cross_reference: NCI_KEGG:C91471

Non-Homologous End-Joining Pathway
type: Class
subclass of: DNA Repair Pathway
definition: Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
PMOID: PMO:00014486
Subclass_of: DNA Repair Pathway
Synonym: NHEJ Pathway
Synonym: Non-homologous end-joining
Tree Number: T4.4.6
database_cross_reference: NCI:C91444
database_cross_reference: NCI_KEGG:C91444

Nucleotide Excision Repair Pathway
type: Class
subclass of: DNA Repair Pathway
definition: Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
PMOID: PMO:00014487
Subclass_of: DNA Repair Pathway
Synonym: Nucleotide excision repair
Tree Number: T4.4.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91447
database_cross_reference: NCI_KEGG:C91447

Drug Pathway
type: Class
subclass of: Biochemical Pathway
definition: An elaboration of a sequence of physiological events that are elicited by the administration of a drug.
PMOID: PMO:00014488
Subclass_of: Biochemical Pathway
Tree Number: T4.5
database_cross_reference: NCI:C91821

Acetaminophen Pathway
type: Class
subclass of: Drug Pathway
definition: Acetaminophen is one of the world's most commonly used drugs, used for the treatment of pain and fever. Like other NSAIDs (non-steroidal anti-inflammatory drugs), acetaminophen has a unique activity profile based in part on its action at its molecular targets, the cyclooxygenase enzymes that produce prostaglandins responsible for pain, fever and inflammation. Until very recently, only two Cox enzymes, Cox-1 and Cox-2, were known to be targets of NSAIDS. Cox-1 is expressed in a constitutive manner throughout most tissues, and plays an essential role in maintaining the integrity of the stomach mucosal lining. Cox-2 is an inducible enzyme whose expression is induced by inflammation. NSAIDS selective for Cox-2 have been developed to avoid the development of ulcers by some non-selective NSAIDs, including aspirin. While these two isoforms were sufficient to account for most NSAIDs pharmacology, the actions of acetaminophen remained hard to explain on the basis of inhibiting Cox-1 and Cox-2 alone, such as its efficacy at reducing pain and fever but lack of anti-inflammatory effects. A novel Cox enzyme isoform encoded by the Cox-1 gene, Cox-3, contains an additional 30-34 amino acids and is expressed selectively in the brain. This insertion alters the pharmacology of the Cox enzyme, making Cox-3 sensitive to selective inhibition by acetaminophen and other drugs that reduce pain and fever but have weak anti-inflammatory activity, explaining the pharmacology of these drugs. Another characteristic of acetaminophen is its liver toxicity when taken at high doses. The target of this toxicity has also been recently been revealed. The nuclear receptor CAR is activated by many different exogenous compounds, including acetaminophen, inducing expression of three cytochrome P450 enzymes that transform acetaminophen into NAPQI, a reactive and toxic metabolite. Blocking CAR activation with an antagonist protects against acetaminophen liver toxicity, suggesting a strategy to treat acetami…
PMOID: PMO:00014489
Subclass_of: Drug Pathway
Synonym: Mechanism of Acetaminophen Activity and Toxicity
Tree Number: T4.5.1
database_cross_reference: NCI:C38970
database_cross_reference: NCI_BioC:C38970

Aspirin Inhibition of Platelet Activation Pathway
type: Class
subclass of: Drug Pathway
definition: Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotting. The protease-activated receptors PAR1 and PAR4 are cleaved by the protease thrombin, releasing a tethered peptide ligand that activates the receptor and triggers intracellular calcium release. Platelets from mice lacking the PAR4 gene are not activated by thrombin and are impaired in clotting, supporting the importance of thrombin signaling through PAR4 in clotting. Human platelets express both PAR1 and PAR4, with PAR1 playing a more dominant role in clotting in humans. Calcium release induced by PARs activates PKC, modulating integrin alpha IIB beta 3 (glycoprotein IIb/IIIa) and opening integrin ligand binding sites to contribute to platelet aggregation. Intracellular calcium increases induced by thrombin activate phospholipase A2, liberating arachidonic acid, the first step in prostaglandin and thromboxane biosynthesis. Ras/Map kinase activation by the PAR receptors also activates phospholipase A2. The activation of PAR-induced platelet aggregation is inhibited by aspirin, indicating that thromboxane production induced by PAR signaling contributes to platelet activation. Arachidonic acid is converted to the prostaglandin PGG2 by the enzyme Cox-1 in platelets, and Cox-1 is inhibited by aspirin, reducing thromboxane A2 production by platelets. Thromboxane is a potent vasoconstrictor and platelet activator, so inhibition of Cox-1 in platelets by aspirin may explain some of the cardioprotective actions of aspirin. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014490
Subclass_of: Drug Pathway
Synonym: Aspirin Blocks Signaling Pathway Involved in Platelet Activation
Tree Number: T4.5.2
database_cross_reference: NCI:C39235
database_cross_reference: NCI_BioC:C39235

Corticosteroid Cardioprotection Pathway
type: Class
subclass of: Drug Pathway
definition: Myocardial infarction damages heart tissue both during the initial ischemia and the subsequent reperfusion of tissues with oxygen. Corticosteroids can protect cardiac tissue from damage following a heart attack, but the mechanisms by which corticosteroids are cardioprotective have not been clear and negative side effects such as reduced wound healing may result from their use. Corticosteroids exert a variety of actions through binding to the glucocorticoid receptor (GR), a member of the steroid hormone receptor gene family. GR acts as a ligand-dependent transcription factor, but some of the cardioprotective effects mediated by GR-bound corticosteroids are non-transcriptional in nature. Glucocorticoids are commonly used as anti-inflammatory drugs in a variety of conditions, and some of their effects in the heart result from inhibition of the inflammatory response of heart tissue to ischemia and reperfusion. NF-kB is a transcription factor involved in signaling by inflammatory factors such as TNF, and is repressed by glucocorticoids. Annexin-1 is a calcium-dependent phospholipid binding protein whose expression is induced by corticosteroids and inhibits the infiltration of neutrophils into tissue, blocking reperfusion-induced inflammatory heart damage. A non-transcriptional cardioprotective effect of glucocorticoids is activation of NO production by endothelial nitric oxide synthase (eNOS). Glucocorticoids activate eNOS through activation of PI3 kinase and AKT and increased NO produced by eNOS can diffuse into surrounding tissues to prevent clotting and cause vasodilation. The beta-2 adrenergic receptor can also activate PI3 kinase and may synergize with glucocorticoids in this pathway. The atrial natriuretic factor (ANF) is a peptide secreted by the atrial wall in response to increased atrial pressure such as occurs during cardiac failure and to be decreased by myocardial infarction. Glucocorticoids increase the secretion of ANF by acting at the transcriptional level…
PMOID: PMO:00014491
Subclass_of: Drug Pathway
Synonym: Corticosteroids and cardioprotection
Tree Number: T4.5.3
database_cross_reference: NCI:C39091
database_cross_reference: NCI_BioC:C39091

Flumazenil Cardioprotection Pathway
type: Class
subclass of: Drug Pathway
definition: Flumazenil is a benzodiazepine receptor antagonist. It is used clinically to reverse the effects of benzodiazepines in conscious sedation, general anesthesia, and management of suspected benzodiazepine overdose. Kochs and colleagues reported that flumazenil might be beneficial in protecting against cerebral ischemia. Rapid administration of flumazenil produced minimal coronary and left ventricular hemodynamic responses. Thus this agent may be a potential candidate for clinical application in patients with ischemic heart diseases if it can mimic preconditioning to protect the heart. The study by Zhang and Yao indicates that flumazenil mimics preconditioning in cardiomyocytes via the generation of H2O2 as the reactive oxygen species (ROS). H2O2 opens mitochondrial KATP channels and inhibits GABA receptors via protein kinase C-epsilon in cardiomyocytes inducing ischemic preconditioning. This signal transduction and preconditioning protects ischemic cardiomyocytes. Zhang et al. indicate that the potential beneficial effects of Allitridum appear to mimic the same effects as flumazenil, to precondition cardiomyocytes, via the stimulation of PKC. Allitridum is an extract of garlic taken as a medicine in China for over 3000 years. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014492
Subclass_of: Drug Pathway
Synonym: Cardiac Protection Against ROS
Tree Number: T4.5.4
database_cross_reference: NCI:C39081
database_cross_reference: NCI_BioC:C39081

FosB Drug-induction Pathway
type: Class
subclass of: Drug Pathway
definition: Drug addiction is associated with long-term behavioral changes, suggesting a long-lived transcriptional regulator that responds to chronic drug exposure might cause long-term changes in neuronal function. Neurons in the nucleus accumbens and striatum are involved in addiction and have altered synaptic properties in response to chronic drug exposure. Along with JunD, delta-FosB is a component of an AP-1 transcription factor that accumulates in these key brain regions after chronic exposure to drugs of abuse, including morphine, amphetamine, alcohol, and cocaine. Delta-FosB is an unusually stable splice variant of the immediate early FosB gene, accumulating and persisting in the brain long after drug is removed. One component of FosB stability is post-translational modification through phosphorylation. Genetically modified mice that selectively overexpress this protein in neurons have increased sensitivity to cocaine and increased apparent reward response to drug administration, as expected in addiction, supporting the role of delta-FosB in addiction. The target genes regulated by delta-FosB include the GluR2 subunit of the AMPA glutamate receptor. Increased expression of GluR2 modifies the conductance and calcium flux of neurons, and may be responsible for increased reward responses to drug. Another target of delta-FosB is the dynorphin gene, the ligand for the kappa opioid receptor, further altering reward responses to drugs. The cell cycle checkpoint kinase cdk2 is activated by delta-FosB and acts on Darpp-32 to alter dopaminergic signaling. Although delta-FosB is very stable, it does degrade after several weeks, while the behavioral changes of drug addiction persist much longer after drug exposure ends. Changes in chromatin structure or changes in synaptic structure induced initially by delta-FosB may persist long after delta-FosB is no longer present, allowing behavioral changes to persist. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014493
Subclass_of: Drug Pathway
Synonym: FOSB gene expression and drug abuse
Tree Number: T4.5.5
database_cross_reference: NCI:C39083
database_cross_reference: NCI_BioC:C39083

Inhibition of Cellular Proliferation by Gleevec Pathway
type: Class
subclass of: Drug Pathway
definition: The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia. While traditional cytotoxic cancer treatments such as chemotherapy or radiation therapy kill all dividing cells, Gleevec acts on a molecular target by a mechanism that is more specific to cancer cells. Traditional cytotoxic cancer agents have serious side effects such as nausea, weight loss, hair loss and severe fatigue that result from their lack of specificity in killing cells. Gleevec was designed as an inhibitor of a specific receptor associated with CML, and so produces less severe side effects than other cancer agents. CML is associated in most cases with a specific chromosomal defect, a translocation between chromosomes 9 and 22 that creates the Philadelphia chromosome. This translocation creates the abnormal bcr-abl protein, a fusion of the Abl gene with another gene called Bcr. The kinase activity of Abl in the bcr-abl fusion is activated and unregulated, driving the uncontrolled cell growth observed in CML. White blood cells containing the bcr-abl mutation become able to proliferate in the absence of growth factors they normally require. Gleevec inhibits Abl kinase activity, helping to reverse uncontrolled cell growth. Gleevec also inhibits the PDGF tyrosine kinase and the c-kit tyrosine kinase. There are a variety of cellular substrates of the bcr-abl kinase that may be involved in cellular transformation. Some of the downstream factors in bcr-abl signaling include PI3 kinase/AKT and STAT transcription factors. The activation of bcr-abl also represses apoptosis through induction of anti-apoptosis factors such as Bad, allowing transformed cells to divide. JAK2 kinase activity appears to be one target of bcr-abl. Grb-2 phosphorylation by bcr-abl may play a role in down-regulation of tyrosine kinase signaling. STAT5 may be involved in the failure of apoptosis in bcr-abl cells. In addition to supporting the idea tha…
PMOID: PMO:00014494
Subclass_of: Drug Pathway
Synonym: Inhibition of Cellular Proliferation by Gleevec
Tree Number: T4.5.6
database_cross_reference: NCI:C39094
database_cross_reference: NCI_BioC:C39094

Genetic Information Processing Pathway
type: Class
subclass of: Biochemical Pathway
definition: A sequence of biological or biochemical events that are involved in the conversion of genetic information into physiologically active molecules, such as functional RNA and proteins.
PMOID: PMO:00014495
Subclass_of: Biochemical Pathway
Synonym: Genetic Information Processing
Tree Number: T4.6
database_cross_reference: NCI:C39736
database_cross_reference: NCI_KEGG:C39736

Aminoacyl-tRNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
PMOID: PMO:00014496
Subclass_of: Genetic Information Processing Pathway
Tree Number: T4.6.1

DNA Replication Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.
PMOID: PMO:00014497
Subclass_of: Genetic Information Processing Pathway
Synonym: DNA replication
Tree Number: T4.6.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91448
database_cross_reference: NCI_KEGG:C91448

Double Stranded RNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: About 8% of human genes have been estimated to carry out transcription from both DNA strands, resulting in significant level of endogenous antisense RNA. In the cytoplasm the antisense RNA leads to formation of long dsRNA, which activates the interferon and RNA-dependent protein kinase antiviral pathway. Most endogenous antisense RNA is made in the nucleus and two responses have been suggested for the nuclear dsRNA. First, the dsRNA may be processed by enzymes of the family of adenosine deaminases that act on RNA (ADAR). The deaminated dsRNAs contain various levels of inosines. dsRNA containing high level of inosines are tightly bound by a protein complex that results in their nuclear retention. dsRNA containing low level of inosines may be able to exit the nucleus. Second, the nuclear dsRNA can lead to gene silencing and heterochromatin formation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014498
Subclass_of: Genetic Information Processing Pathway
Synonym: Antisense Pathway
Synonym: RNA Interference Pathway
Synonym: dsRNA Biosynthesis Pathway
Tree Number: T4.6.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38987
database_cross_reference: NCI_BioC:C38987

Gene Silencing Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: Packaging of DNA into chromatin allows the cell to store its genetic information efficiently and has an important role in regulating gene expression. Recent studies have revealed that chromatin structure can be altered by covalent modification of nucleosomes, in particular acetylation and methylation of the core histone tails. Histone hyperacetylation usually characterizes active chromatin, while histone deacetylation correlates with repressed transcription. The Polycomb group (PcG) proteins are constituents of evolutionary highly conserved molecular pathways regulating cell fate in several tissues through diverse mechanisms, including 1) regulation of self-renewal/proliferation, 2) regulation of senescence/immortalization, 3) interaction with the initiation transcription machinery, 4) interaction with chromatin-condensation proteins, 5) modification of histones, 6) inactivation of paternal X chromosome, and 7) regulation of cell death. The PcG proteins form multimeric protein complexes, PRC1 and PRC2 which are involved in the heritable, stable repression of genes through modification of chromatin structure. The EED-EZH2 complex (PRC 2 complex) acts early in development to set the stage for the long term repressive PRC1 complex. The PRC2 complex is probably tethered to promoters of affected genes through the interaction with specific DNA binding factors, such as YY1, a zinc finger transcription factor that acts as both a positive and negative regulator of transcription of cellular and viral genes. The EED-EZH2 proteins interact with histone deacetylase core complex consisting of the histone deacetylases HDAC1 and HDAC2 and the histone binding proteins RbAp48 and RbAp46. Histone deacetylation is probably a prerequisite for subsequent methylation, as histone tails cannot be acetylated and methylated in the same time. The PRC complex specifically methylates nucleosomal histone H3 at lysine 27, providing an epigenetic mark for binding of PRC1 complex. The histone methyl…
PMOID: PMO:00014499
Subclass_of: Genetic Information Processing Pathway
Synonym: The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails
Tree Number: T4.6.4
database_cross_reference: NCI:C39200
database_cross_reference: NCI_BioC:C39200

Internal Ribosome Entry Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: Control of translation is one of the major regulatory events in eukaryotic gene expression. Internal ribosome entry sites (IRES) were first discovered in picornavirus RNAs but it is now clear that IRESs are also present in the 5' untranslated region of many eukaryotic genes including those encoding growth factors (e.g., VEGF, FGF2 and PDGF), genes whose protein products are associated with apoptosis (e.g., Apaf-1, IXAP), transcription factors (e.g., c- myc), and the potassium channel Kv1.4. IRES allows the ribosomes to be recruited to an initiator AUG, which is some distance from the 5' end of the message RNA to bypass the Kozak scanning mechanism. In the Kozak scanning model, the 40S ribosomal subunit bearing Met-tRNAmet and initiation factors, binds near the capped 5' end of the mRNA and travels along the mRNA until it comes to the first AUG. IRES-dependent initiation of protein synthesis occurs during apoptosis or some viral infection (e.g., picornavirus). A component of the cap-binding complex eIF-4F, translation initiation factor eIF-4G, is cleaved (by caspases or viral protein 2A) to give a modified form of cap-binding complex that is cap-independent. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014500
Subclass_of: Genetic Information Processing Pathway
Synonym: Internal Ribosome entry pathway
Tree Number: T4.6.5
database_cross_reference: NCI:C39134
database_cross_reference: NCI_BioC:C39134

mRNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
PMOID: PMO:00014501
Subclass_of: Genetic Information Processing Pathway
Synonym: mRNA Biosynthesis (Eukaryotes)
Tree Number: T4.6.6
database_cross_reference: NCI:C38837
database_cross_reference: NCI_KEGG:C38837

Basal Transcription Factor Assembly Pathway
type: Class
subclass of: mRNA Biosynthesis Pathway
PMOID: PMO:00014502
Subclass_of: mRNA Biosynthesis Pathway
Synonym: Basal transcription factors
Tree Number: T4.6.6.1
database_cross_reference: NCI:C91428
database_cross_reference: NCI_KEGG:C91428

RNA Polymerase Assembly Pathway
type: Class
subclass of: mRNA Biosynthesis Pathway
PMOID: PMO:00014503
Subclass_of: mRNA Biosynthesis Pathway
Synonym: RNA polymerase
Tree Number: T4.6.6.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91427
database_cross_reference: NCI_KEGG:C91427

Spliceosome Pathway
type: Class
subclass of: mRNA Biosynthesis Pathway
definition: After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
PMOID: PMO:00014504
Subclass_of: mRNA Biosynthesis Pathway
Synonym: Spliceosome
Tree Number: T4.6.6.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91451
database_cross_reference: NCI_KEGG:C91451

Polyadenylation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: Gene expression requires the coordination and integration of multiple processes, including transcription, splicing, polyadenylation, nucleocytoplasmic export, and translation of mRNAs. Posttranscriptional addition of poly (A) to the 3' end of mRNA is an important process conserved from bacteria to humans. In eukaryotes, polyadenylation is essential for the stability of many mRNAs and also influences the efficiency of translation. Most histone-mRNAs and all snRNAs (except U6), however are not polyadenylated. The mature mRNA moves to the nuclear surface and is exported through nuclear pores. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014505
Subclass_of: Genetic Information Processing Pathway
Synonym: Polyadenylation of mRNA
Synonym: mRNA polyadenylation
Synonym: mRNA polyadenylylation
Tree Number: T4.6.7
database_cross_reference: GO:GO:0006378
database_cross_reference: NCI:C39034
database_cross_reference: NCI_BioC:C39034

Protein Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
PMOID: PMO:00014506
Subclass_of: Genetic Information Processing Pathway
Synonym: Protein Biosynthesis (Eukaryotes)
Tree Number: T4.6.8
database_cross_reference: NCI:C38856
database_cross_reference: NCI_KEGG:C38856

Ribosome Assembly Pathway
type: Class
subclass of: Protein Biosynthesis Pathway
PMOID: PMO:00014507
Subclass_of: Protein Biosynthesis Pathway
Synonym: Ribosome
Tree Number: T4.6.8.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91426
database_cross_reference: NCI_KEGG:C91426

Protein Translation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: The scanning translation initiation model suggests that 40S ribosomal subunit preloaded with factors bind to the 5' end of the mRNA near the cap. The 48S subunit moves along the mRNA until it finds the initiation triplet and in complex with tRNA and 60S subunit forms the first peptide bond. Translation control is mostly regulated at the protein initiation step through translation initiation factors such as eIF2 or eIF4. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014508
Subclass_of: Genetic Information Processing Pathway
Synonym: Eukaryotic protein translation
Tree Number: T4.6.9
database_cross_reference: NCI:C39063
database_cross_reference: NCI_BioC:C39063

RNA Degradation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
PMOID: PMO:00014509
Subclass_of: Genetic Information Processing Pathway
Synonym: RNA degradation
Tree Number: T4.6.10
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91512
database_cross_reference: NCI_KEGG:C91512

RNA Polymerase III Transcription Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: Unlike the RNA polymerase II that transcribes a large variety of genes that encode proteins, RNA polymerase III transcribes only a limited number of genes (i.e., 5S rRNA, tRNA, 7SL RNA, U6 snRNA, and a few other small stable RNAs); however, the transcriptional activities of RNA pol III along with pol I account for 80% of total RNA synthesis. The A and B block sequences found in most pol III promoters are recognized by a multisubunit complex, TFIIIC. The binding of TFIIIC recruits TFIIIB, a complex of polypeptides (in human, TATA-binding protein (TBP), TFIIB-related factor (BRF), and one or more unidentified protein). Once TFIIIB is brought to the general location by TFIIIC and optimally positioned by TBP, the transcription initiates about 30bp downstream. The transcription process requires the melting of dsDNA and participation of TFIIIB. Unlike pol I and II, pol III termination occurs efficiently at four or more T residues without other protein factors. La protein can stimulate the release of RNA and pol III transcription; however, deletion of La has no apparent effect on pol III activity. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014510
Subclass_of: Genetic Information Processing Pathway
Synonym: RNA polymerase III transcription
Tree Number: T4.6.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39225
database_cross_reference: NCI_BioC:C39225

rRNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
PMOID: PMO:00014511
Subclass_of: Genetic Information Processing Pathway
Synonym: rRNA Biosynthesis (Eukaryotes)
Tree Number: T4.6.12
database_cross_reference: NCI:C38863
database_cross_reference: NCI_KEGG:C38863

Spliceosome Assembly Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: The assembly of the spliceosome is a dynamic process that involves both small ribonucleoprotein particles (snRNPs), and non-snRNP proteins. The complete spliceosome consists of 5 snRNPs (U1, U2, U4, U5, and U6) and 50-100 non-snRNP factors. The snRNPs themselves contain a snRNA and a number of different proteins. These proteins can be subdivided into two classes, those specific to the individual snRNP, and those common to all snRNPs. The later group consists of eight polypeptides; B, B', D1, D2, D3, E, F, and G, which bind together in a tight association, and are referred to as the sm proteins. While some of the particle-specific proteins have been well studied, i.e.U1-70K or U1-A, many have only been identified by their molecular weight and have yet to be cloned. These snRNP components are recruited to the pre-mRNA in an ordered manner, and begin with the recognition of exon-intron boundaries. The 5' end of the U1 snRNP recognizes the 5' splice site of the pre-mRNA. This interaction is mediated through conventional base pairing. Subsequently snRNP U1 recognizes and binds to the conserved branch point adenosine site. This step in the splicing cycle is called the commitment complex (CC) and is defined as a point where the formation of a stable splicing complex commits the spliceosome to assemble. Binding of the U1 snRNP encourages binding of U2 snRNP, and is helped by U2AF protein. SR proteins such as ASF/SF2 and SC35, or other intron bridging proteins, mediate the interaction between U1, U2 and U2AF. Binding of these factors facilitate recognition of the 3' splice site, and this whole complex is called the E (Early) complex. Spliceosomal A Complex is formed following recruitment of U2 snRNP to the branch point sequence. Meanwhile, snRNPs U4/U6 and U5 have formed a functional tri-snRNP complex. The association of the tri-snRNP U4/U6-U5 with the pre-spliceosome creates the B complex. Several RNA:RNA interactions occur following this point, including the disassociation…
PMOID: PMO:00014512
Subclass_of: Genetic Information Processing Pathway
Synonym: Spliceosome Assembly
Synonym: spliceosome assembly
Tree Number: T4.6.13
database_cross_reference: GO:GO:0000245
database_cross_reference: NCI:C39233
database_cross_reference: NCI_BioC:C39233

Splicing Regulation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: While transcriptional regulation is often viewed as the most prevalent way extracellular signals act to regulate gene expression, post-transcriptional regulation of splicing, RNA stability, and translation are also regulated by extracellular signals. Sam68, a member of a family of RNA-binding proteins called STAR proteins, mediates alternative splicing in response to extracellular signals, such as altered splicing of CD44 in response to phorbol ester treatment of T cells. RNA binding and activity of SAM68 is regulated by upstream signals through phosphorylation and modulating of its interaction with other proteins, itself, and with RNA. Phorbol ester treatment of T cells stimulates the ras/ Map kinase pathway, activating Erk and phosphorylation of Sam68, inducing alternative splicing of CD44 and perhaps other cellular RNA targets. Sam68 is localized in the nucleus to a specific substructure called the Sam68/SLM Nuclear Bodies, colocalizing with splicing factors and helping to link signal transduction with RNA processing. Sam68 has been suggested to play a role in a variety of pathways, including insulin signaling and HIV gene expression, substituting for the activity of viral Rev protein, and being regulated by arginine methylation as well as phosphorylation. In addition to the role of Sam68 regulating posttranscriptional gene expression, Sam68 also interacts with transcription factors such as CBP and appears to regulate gene expression. Sam68 also appears to play a role in cell cycle progression through influencing RNA processing. During mitosis SAM68 is tyrosine phosphorylated and associated with Src. The interaction of Sam68 with RNA is repressed by this phosphorylation, whereas interaction of Sam68 with Ras-GAP is stimulated by phosphorylation. Sam68 appears to be downregulated in tumors and transformed cells and its expression is reduced during mitosis, suggesting it inhibits proliferation. The RNA binding domain in Sam68, called a KH domain, is absent in a spl…
PMOID: PMO:00014513
Subclass_of: Genetic Information Processing Pathway
Synonym: Regulation of Splicing through Sam68
Tree Number: T4.6.14
database_cross_reference: NCI:C39228
database_cross_reference: NCI_BioC:C39228

Telomere Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: Telomeres, which define the ends of chromosomes, consist of short, tandemly repeated DNA sequences loosely conserved in eukaryotes. Telomerase is a ribonucleoprotein complex which in vitro recognizes a single-stranded G-rich telomere primer and adds multiple telomeric repeats to its 3-prime end by using an RNA template. Telomerase may also have a role in de novo formation of telomeres. Telomerase has been identified in many cultured cell lines and actively dividing cell types. The active reverse transcriptase component has been identified as the TERT protein. The presence of this factor determines the availability of the telomerase function. The TERT protein has a high turnover rate and its expression is regulated by factors that promote growth (c-MYC, v-k-ras, Bcl-2, and E6) and inhibiting factors (RB and p53) that promote cell death or that block cell division. It appears that the regulation of active telomerase has many levels and can be inhibited by TEP1 not releasing TERT or by TRF1 which binds the end repeats and prevents access to the chromosome ends. Additional modulation is due to phosphorylation by PKC and AKT or dephosphorylation by PP2A. Human telomeres consist of many kilobases of (TTAGGG)n together with various associated proteins. Small amounts of these terminal sequences are lost from the tips of the chromosomes during each S phase because of incomplete DNA replication, but de novo addition of TTAGGG repeats by the enzyme telomerase compensates for this loss. Many human cells progressively lose terminal bases with each cell division, a loss that correlates with the apparent absence of telomerase in these cells. There has been considerable interest in the possible relationship between human telomeres and cellular senescence and immortalization. This interest includes the question of a role in the malignant process and the question of the use of telomerase inhibitors as anti-tumor drugs. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014514
Subclass_of: Genetic Information Processing Pathway
Synonym: Telomeres, Telomerase, Cellular Aging, and Immortality
Tree Number: T4.6.15
database_cross_reference: NCI:C39247
database_cross_reference: NCI_BioC:C39247

Transcriptional Repression by DNA Methylation Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: Tumorigenesis is known to be a multistep process in which defects in various cancer genes accumulate. Epigenetic modifications, most importantly DNA methylation events, are frequently involved in transcriptional changes in both tumor suppressor genes and oncogenes. Methylation of cytosine at CpG dinucleotides is a common feature of higher eukaryotic genomes. DNA methylation in the promoter regions of genes is generally correlated with gene silencing. Two underlying mechanisms have been identified. First, binding of transcription factors or enhancer blocking elements, such as CTCF, may be inhibited by DNA methylation. The second and more general mechanism involves proteins that detect methylated DNA through methyl CpG-binding domains (MBDs). Four of these proteins-MBD1, MBD2, MBD3, and MeCP2-have been implicated in methylation-dependent repression of transcription. These proteins mediate recruitment of repressor complexes that include histone deacetylases (HDACs). HDACs remove acetyl groups from lysine residues of histones H3 and H4 that results in condensation of chromatin and thus limit access of transcription factors to promoter regions of genes localized nearby. Well-studied co-repressor complexes include Sin3A and Mi-2/NuRD. MeCP2, a polypeptide characterized by an MBD and a transcriptional repression domain that specifically binds methylated DNA, copurifies with the Sin3A/HDAC corepressor complex. MeCP1 complex is composed of 10 major polypeptides including MBD2 and all of the known NuRD complex components. The two protein complexes share four polypeptides: HDAC1, HDAC2, RbAp46, and RbAp48. In addition, each complex contains unique polypeptides (Sin3A, SAP30, and SAP18 in the Sin3 complex, and Mi2, MTA1, MTA2 and MBD3 in the NuRD complex). The NuRD complex possesses nucleosome remodeling activity because of the presence of Mi2, a member of the SWI2/SNF2 helicase/ATPase family. This complex preferentially binds, remodels, and deacetylates methylated nucleosomes.…
PMOID: PMO:00014515
Subclass_of: Genetic Information Processing Pathway
Synonym: DNA Methylation Pathway
Synonym: Mechanisms of Transcriptional Repression by DNA Methylation
Tree Number: T4.6.16
database_cross_reference: NCI:C91331
database_cross_reference: NCI_BioC:C91331

tRNA Biosynthesis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
PMOID: PMO:00014516
Subclass_of: Genetic Information Processing Pathway
Synonym: tRNA Biosynthesis (Eukaryotes)
Tree Number: T4.6.17
database_cross_reference: NCI:C38874
database_cross_reference: NCI_KEGG:C38874

Ubiquitin-mediated Proteolysis Pathway
type: Class
subclass of: Genetic Information Processing Pathway
definition: Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
PMOID: PMO:00014517
Subclass_of: Genetic Information Processing Pathway
Synonym: Ubiquitin-mediated Proteolysis
Tree Number: T4.6.18
database_cross_reference: NCI:C38881
database_cross_reference: NCI_KEGG:C38881

Metabolic Pathway
type: Class
subclass of: Biochemical Pathway
definition: An elaboration of the known steps and interactions for the metabolism of a compound.
PMOID: PMO:00014518
Subclass_of: Biochemical Pathway
Synonym: Metabolic Pathways
Synonym: Metabolic pathway
Synonym: Metabolic pathway (function)
Synonym: Metabolic pathway, function
Synonym: Metabolic pathway, function (observable entity)
Synonym: Metabolism
Synonym: Pathway, Metabolic
Synonym: Pathways, Metabolic
Synonym: metabolic pathway
Synonym: metabolic pathways
Tree Number: T4.7
database_cross_reference: CHV:0000057416
database_cross_reference: MSH:D053858
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C18611
database_cross_reference: NCI_KEGG:C18611
database_cross_reference: SNOMEDCT_US:129457002

Amino Acid Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
PMOID: PMO:00014519
Subclass_of: Metabolic Pathway
Synonym: Amino Acid Metabolism - Reference Pathway
Tree Number: T4.7.1
database_cross_reference: NCI:C39730
database_cross_reference: NCI_KEGG:C39730

Alanine, Aspartate and Glutamate Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014520
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Alanine, aspartate and glutamate metabolism
Tree Number: T4.7.1.1
database_cross_reference: NCI:C91410
database_cross_reference: NCI_KEGG:C91410

Arginine and Proline Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014521
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Arginine and Proline Metabolism
Synonym: Urea Cycle and Metabolism of Amino Groups
Tree Number: T4.7.1.2
database_cross_reference: NCI:C38785
database_cross_reference: NCI_KEGG:C38785

Arginine, Histidine, Glutamate, Glutamine, and Proline Degradation Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
definition: Glutamine is converted to glutamate by glutaminase, or several other enzymes, by the removal of the amide nitrogen. Proline is first converted to a Schiff base and then converted by hydrolysis to glutamate-5-semialdehyde. All of these changes occur on the same carbon. Arginine and histidine contain 5 adjacent carbons and a sixth carbon attached through a nitrogen atom. The catabolism of these amino acids is thus slightly more complicated than glutamine or proline. Arginine is converted to ornithine and urea. Ornithine is further transaminated to produce glutamate-5-semialdehyde. Glutamate-5-semialdehyde is converted to glutamate. Tetrahydrofolate is the cofactor in the final step converting histidine to glutamate. Transamination or deamination of glutamate produces a-ketoglutarate which feeds into the citric acid cycle. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014522
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Catabolic Pathways for Arginine, Histidine, Glutamate, Glutamine, and Proline
Tree Number: T4.7.1.3
database_cross_reference: NCI:C38993
database_cross_reference: NCI_BioC:C38993

Biosynthesis of Cysteine Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
definition: In animals, the sulfur-containing amino acid cysteine is synthesized from homocysteine, which is itself derived from metabolism of the amino acid methionine. Methionine is an essential amino acid for animals, making cysteine indirectly an essential amino acid as well. Homocysteine condenses with serine to form cystathionine, which is deaminated and hydrolyzed to form cysteine and alpha-ketobutyrate. While the sulfur in cysteine comes from homocysteine, the rest of the molecule comes from the initial serine residue. Cysteine biosynthesis occurs by a distinct mechanism in plants and prokaryotes. Cysteine is an important amino acid for all organisms due to the role it plays in protein folding. The formation of disulfide linkages between cysteine residues helps to stabilize the tertiary and quaternary structure of proteins. Disulfide linkages are most common in secreted proteins, where proteins are exposed to more oxidizing conditions that are found in the cellular interior. Elevated blood levels of homocysteine are a risk factor for the development of cardiovascular disease. One of the causes of elevated homocysteine is a genetic lack of cystathionine beta-synthase and excess methionine intake may be another explanation. Control of methionine intake and supplementing folic acid and vitamin B12 in the diet are used to lower homocysteine levels. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014523
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Biosynthesis of Cysteine in Mammals
Synonym: Mammalian Pathway for Cysteine Biosynthesis
Tree Number: T4.7.1.4
database_cross_reference: NCI:C91319
database_cross_reference: NCI_BioC:C91319

Biosynthesis of Glycine and Serine Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
definition: Intermediates in energy production pathways such as glycolysis and the Kreb's cycle are commonly the starting point for the biosynthesis of amino acids. The glycolytic intermediate 3-phosphoglycerate is the starting point for the biosynthesis of serine and glycine. First, 3-phosphoglycerate is oxidized and then transaminated to produce 3-phosphoserine. Phosphoserine hydrolase hydrolyzes the phosphate in 3-phosphoserine to produce serine. The side chain carbon of serine is removed to create glycine, which has only hydrogen as its side chain. The removal of the serine side chain is accomplished by transferring the carbon to tetrahydrofolate, a carrier of one-carbon groups. Genetic deficiency of the first enzyme in the pathway, 3-phosphoglycerate dehydrogenase, leads to impaired myelination of neurons and impaired development of the central nervous system. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014524
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Biosynthesis of Glycine and Serine
Tree Number: T4.7.1.5
database_cross_reference: NCI:C91320
database_cross_reference: NCI_BioC:C91320

Biosynthesis of Spermidine and Spermine Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
definition: The polyamines spermidine and spermine are expressed in a variety of tissues and are involved in the regulation of apoptosis, cellular proliferation, and progression through the cell cycle. Depletion of polyamines appears to reduce cell growth, and increased polyamine expression is associated with the cancer development and progression, making polyamine biosynthesis a target for the control of cancer. As positively charged amines, spermine and spermidine interact with DNA and may exert some of their effects through this interaction. Ornithine, one of the starting materials for polyamine biosynthesis, is derived from the amino acid arginine as part of the urea cycle. The enzyme ornithine decarboxylase produces putrescine from ornithine. Amino-propyl groups from decarboxylated adoMet are progressively added to putrescine to produce first spermidine and then spermine. Ornithine decarboxylase expression appears to be induced in some types of cancer, particularly skin cancer, and ODC inhibition to cause tumor regression. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014525
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Biosynthesis of Spermidine and Spermine
Tree Number: T4.7.1.6
database_cross_reference: NCI:C91324
database_cross_reference: NCI_BioC:C91324

Catabolic Pathway for Asparagine and Aspartate
type: Class
subclass of: Amino Acid Metabolism Pathway
definition: Aspartate and asparagine are catabolized into oxaloacetate and the Kreb's cycle in a fairly direct pathway for amino acids with four carbons. The first step for asparagine catabolism is hydrolysis by the enzyme asparaginase, releasing aspartate and ammonia. Aspartate is then transaminated by aspartate transaminase to exchange its amino group onto alpha-ketoglutarate and be converted into oxaloacetate. As part of the Kreb's cycle, the carbon skeleton of oxaloacetate can generate energy and provide material for biosynthesis. The enzyme asparaginase is used as a cancer treatment through injection. Some cancers such as leukemias are highly dependent on asparagine circulating in the blood that comes from the diet. The required asparagine helps to support the rapid growth of malignant cells. Injection of asparaginase metabolizes the asparagine in the blood, withdrawing the supply of this essential nutrient from tumor cells, and causing asparagine-dependent tumor cells to die. Normal cells provide enough asparagine for their own needs through biosynthesis and are affected to a lesser extent by this treatment. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014526
Subclass_of: Amino Acid Metabolism Pathway
Tree Number: T4.7.1.7
database_cross_reference: NCI:C91321
database_cross_reference: NCI_BioC:C91321

Catabolic Pathways for Alanine, Glycine, Serine, Cysteine, Tryptophan, and Threonine
type: Class
subclass of: Amino Acid Metabolism Pathway
definition: Amino acids in the diet have one of two fates - either they are incorporated into proteins or they are broken down for energy and metabolic intermediates. They are not stored and the body also does not excrete them intact. The metabolic pathways that lead to degradation of amino acids funnel their carbon chains into metabolic intermediates that generate energy, and their amino groups into the urea cycle to be excreted. The amino acids alanine, glycine, serine, cysteine, tryptophan and threonine all have a common endpoint, the metabolic intermediate pyruvate. Threonine is converted to glycine through the removal of an acetaldehyde group, and glycine is then converted to serine, then pyruvate. More than one path can remove the sulfur and nitrogen groups of serine to create pyruvate. Part of tryptophan is found in alanine, which is converted directly to pyruvate through transamination. The removal of amino nitrogens commonly occurs through transamination, transferring the nitrogen to alpha-ketobutyrate to create glutamate. All of these amino acids are termed glucogenic since the pyruvate resulting from their metabolism can enter gluconeogenesis to create glucose. Pyruvate can also be converted by pyruvate dehydrogenase into acetyl-CoA, which can enter into the Kreb's cycle to generate ATP, be converted to ketone bodies, or be directed into fatty acid biosynthesis. The importance of amino acid degradation is demonstrated by a genetic defect in serine hydroxymethyl transferase. In individuals with this condition, glycine accumulates to toxic levels in the body due to a lack of other mechanisms of metabolism. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014527
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Conversion of Alanine, Glycine, Serine, Cysteine, Tryptophan, and Threonine into Pyruvate
Tree Number: T4.7.1.8
database_cross_reference: NCI:C91322
database_cross_reference: NCI_BioC:C91322

Cysteine and Methionine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014528
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Cysteine and methionine metabolism
Tree Number: T4.7.1.9
database_cross_reference: NCI:C91411
database_cross_reference: NCI_KEGG:C91411

Glycine, Serine and Threonine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
definition: Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis, and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate.
PMOID: PMO:00014529
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Glycine, Serine and Threonine Metabolism
Tree Number: T4.7.1.10
database_cross_reference: NCI:C38817
database_cross_reference: NCI_KEGG:C38817

Histidine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014530
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Histidine Metabolism
Synonym: histidine metabolic process
Synonym: histidine metabolism
Tree Number: T4.7.1.11
database_cross_reference: GO:GO:0006547
database_cross_reference: NCI:C38824
database_cross_reference: NCI_KEGG:C38824

Lysine Biosynthesis Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014531
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Lysine Biosynthesis
Synonym: lysine anabolism
Synonym: lysine biosynthesis
Synonym: lysine biosynthetic process
Synonym: lysine formation
Synonym: lysine synthesis
Tree Number: T4.7.1.12
database_cross_reference: GO:GO:0009085
database_cross_reference: NCI:C38832
database_cross_reference: NCI_KEGG:C38832

Lysine Degradation Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014532
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Lysine Degradation
Tree Number: T4.7.1.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38833
database_cross_reference: NCI_KEGG:C38833

Methionine, Isoleucine, Threonine and Valine Degradation Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
definition: The carbon chains of methionine, isoleucine, threonine, and valine are broken down to produce succinyl-CoA, which feeds into the Citric Acid Cycle. Methionine donates its methyl group via S-adenosylmethionine to one of several acceptors and the four remaining carbons are the backbone of propionyl-CoA that is subsequently converted to succinyl-CoA. The transdeamination and decarboxylation of valine are followed by a series of steps resulting in the formation of propionyl-CoA. Isoleucine also undergoes transdeamination, followed by oxidative decarboxylation. These steps yield propionyl-CoA as well as acetyl-CoA. Deficiency in the steps that convert isoleucine to propionyl-CoA causes sudden unexplained infant death, Reye-like syndrome, cardiomyopathy, and skeletal myopathy. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014533
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine
Tree Number: T4.7.1.14
database_cross_reference: NCI:C39151
database_cross_reference: NCI_BioC:C39151

Phenylalanine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014534
Subclass_of: Amino Acid Metabolism Pathway
Synonym: L-phenylalanine metabolic process
Synonym: L-phenylalanine metabolism
Synonym: Phenylalanine Metabolism
Synonym: phenylalanine metabolism
Tree Number: T4.7.1.15
database_cross_reference: GO:GO:0006558
database_cross_reference: NCI:C38848
database_cross_reference: NCI_KEGG:C38848

Phenylalanine, Tyrosine and Tryptophan Biosynthesis Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014535
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Phenylalanine, Tyrosine and Tryptophan Biosynthesis
Tree Number: T4.7.1.16
database_cross_reference: NCI:C38849
database_cross_reference: NCI_KEGG:C38849

Tryptophan Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014536
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Tryptophan Metabolism
Synonym: tryptophan metabolic process
Synonym: tryptophan metabolism
Tree Number: T4.7.1.17
database_cross_reference: GO:GO:0006568
database_cross_reference: NCI:C38875
database_cross_reference: NCI_KEGG:C38875

Tyrosine Metabolism Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014537
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Tyrosine Metabolism
Synonym: metabolism tyrosine
Synonym: tyrosine metabolic process
Synonym: tyrosine metabolism
Tree Number: T4.7.1.18
database_cross_reference: CHV:0000055334
database_cross_reference: GO:GO:0006570
database_cross_reference: NCI:C38879
database_cross_reference: NCI_KEGG:C38879

Valine, Leucine and Isoleucine Biosynthesis Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014538
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Valine, Leucine and Isoleucine Biosynthesis
Tree Number: T4.7.1.19
database_cross_reference: NCI:C38883
database_cross_reference: NCI_KEGG:C38883

Valine, Leucine and Isoleucine Degradation Pathway
type: Class
subclass of: Amino Acid Metabolism Pathway
PMOID: PMO:00014539
Subclass_of: Amino Acid Metabolism Pathway
Synonym: Valine, Leucine and Isoleucine Degradation
Tree Number: T4.7.1.20
database_cross_reference: NCI:C38884
database_cross_reference: NCI_KEGG:C38884

Biosynthesis of Secondary Metabolites Pathway
type: Class
subclass of: Metabolic Pathway
PMOID: PMO:00014540
Subclass_of: Metabolic Pathway
Synonym: Biosynthesis of Secondary Metabolites - Reference Pathway
Tree Number: T4.7.2
database_cross_reference: NCI:C39734
database_cross_reference: NCI_KEGG:C39734

Butirosin and Neomycin Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
PMOID: PMO:00014541
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Butirosin and neomycin biosynthesis
Tree Number: T4.7.2.1
database_cross_reference: NCI:C91413
database_cross_reference: NCI_KEGG:C91413

Caffeine Metabolism Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
PMOID: PMO:00014542
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Caffeine metabolism
Tree Number: T4.7.2.2
database_cross_reference: NCI:C91437
database_cross_reference: NCI_KEGG:C91437

Flavonoids, Stilbene and Lignin Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
PMOID: PMO:00014543
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Flavonoids, Stilbene and Lignin Biosynthesis
Tree Number: T4.7.2.3
database_cross_reference: NCI:C38808
database_cross_reference: NCI_KEGG:C38808

Formation of Ketone Bodies from Acetyl-CoA Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
definition: The acetyl-CoA produced by mitochondrial beta-oxidation of fatty acids enters the Kreb's cycle to produce energy, but that is not the only fate of acetyl-CoA. In liver mitochondria, some acetyl-CoA is converted to acetoacetate, beta-hydroxybutyrate, and acetone, collectively called ketone bodies. Ketone bodies are transported to other tissues such as brain, muscle or heart where they are converted back to acetyl-CoA to serve as an energy source. The brain normally uses only glucose for energy, but during starvation ketone bodies can become the main energy source for the brain. In the metabolic condition called ketosis, ketone bodies are produced faster than they are consumed by tissues and the smell of acetone can be detected on a person's breath. The smell of acetone is one indication that a person may have diabetes. The consumption of high-fat/low carbohydrate diets has been used as a weight loss program by many, intentionally inducing ketosis to consume fat stores, but these ketogenic diets can cause unwanted side effects related to increased urea production resulting from protein intake and risk of heart disease from increased cholesterol and fat intake. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014544
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Formation of Ketone Bodies from Acetyl-CoA
Tree Number: T4.7.2.4
database_cross_reference: NCI:C91328
database_cross_reference: NCI_BioC:C91328

Indole and Ipecac Alkaloid Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
PMOID: PMO:00014545
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Indole alkaloid biosynthesis
Synonym: Indole and Ipecac Alkaloid Biosynthesis
Tree Number: T4.7.2.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38826
database_cross_reference: NCI_KEGG:C38826

Isoquinoline Alkaloid Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
PMOID: PMO:00014546
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Tree Number: T4.7.2.6

Terpenoid Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
PMOID: PMO:00014547
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Terpenoid Biosynthesis
Synonym: Terpenoid backbone biosynthesis
Synonym: terpenoid anabolism
Synonym: terpenoid biosynthesis
Synonym: terpenoid biosynthetic process
Synonym: terpenoid formation
Synonym: terpenoid synthesis
Tree Number: T4.7.2.7
database_cross_reference: GO:GO:0016114
database_cross_reference: NCI:C38872
database_cross_reference: NCI_KEGG:C38872

Tropane, Piperidine and Pyridine Alkaloid Biosynthesis Pathway
type: Class
subclass of: Biosynthesis of Secondary Metabolites Pathway
PMOID: PMO:00014548
Subclass_of: Biosynthesis of Secondary Metabolites Pathway
Synonym: Alkaloid Biosynthesis II
Synonym: Tropane, piperidine and pyridine alkaloid biosynthesis
Tree Number: T4.7.2.8
database_cross_reference: NCI:C38777
database_cross_reference: NCI_KEGG:C38777

Carbohydrate Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
definition: An elaboration of a sequence of biological or biochemical events that play a role in the metabolism of carbohydrates.
PMOID: PMO:00014549
Subclass_of: Metabolic Pathway
Synonym: Carbohydrate Metabolism - Reference Pathway
Tree Number: T4.7.3
database_cross_reference: NCI:C39726
database_cross_reference: NCI_KEGG:C39726

Amino and Nucleotide Sugars Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014550
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Amino sugar and nucleotide sugar metabolism
Synonym: Aminosugars Metabolism
Synonym: Nucleotide Sugars Metabolism
Tree Number: T4.7.3.1
database_cross_reference: NCI:C38840
database_cross_reference: NCI_KEGG:C38840

Ascorbate and Aldarate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014551
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Ascorbate and Aldarate Metabolism
Tree Number: T4.7.3.2
database_cross_reference: NCI:C38786
database_cross_reference: NCI_KEGG:C38786

Butanoate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014552
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Butanoate Metabolism
Tree Number: T4.7.3.3
database_cross_reference: NCI:C38793
database_cross_reference: NCI_KEGG:C38793

Citrate Cycle (TCA Cycle) Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
definition: The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation of carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle, but contain genes for specific segments.
PMOID: PMO:00014553
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Citrate Cycle (TCA cycle)
Tree Number: T4.7.3.4
database_cross_reference: NCI:C38797
database_cross_reference: NCI_KEGG:C38797

Feeder Pathways for Glycolysis
type: Class
subclass of: Carbohydrate Metabolism Pathway
definition: The glycolytic pathway begins with the simple sugar glucose and leads to pyruvate and eventually the Kreb's cycle. Dietary carbohydrates include a variety of sugars that are funneled into glycolysis to supply energy, including other monosaccharides, disaccharides, and polysaccharides like starch. Fructose is an abundant monosaccharide in fruit, and is also found along with glucose in the common disaccharide sucrose. Fructose enters glycolysis by different pathways in the liver and muscle. In muscle, fructose is a substrate of hexokinase, like glucose, and enters the pathway directly as fructose 6-phosphate. In liver, hexokinase is present in very low levels and fructose passes through a more complex pathway. Fructose is first phosphorylated to form fructose 1-phosphate, which is then split into glyceraldehyde and dihydroxyacetone phosphate to enter glycolysis as glyceraldehyde 3-phosphate. The sugar mannose also enters glycolysis at this point, first being converted to mannose 6-phosphate that is then isomerized to produce fructose 6-phosphate. Lactose is a disaccharide found in milk, and is composed of glucose and galactose. Galactose only differs from glucose in its stereochemistry at one position, but must be converted to glucose to enter glycolysis. The first step is phosphorylation to produce galactose 1-phosphate. Then, a UDP nucleotide group is exchanged between galactose 1-phosphate and UDP-glucose. The result of this reaction is the production of glucose 1-phosphate and UDP-galactose. UDP-galactose is enzymatically converted to UDP-glucose, which is then converted to glucose 1-phosphate in the next round of this loop. Glucose 1-phosphate is isomerized to produce glucose 6-phosphate, part of the glycolytic pathway. The complex polysaccharides starch and glycogen differ in their source and in their structure (they have different bonds between each individual sugar unit) but they are both composed entirely of glucose subunits polymerized together. Starch is fo…
PMOID: PMO:00014554
Subclass_of: Carbohydrate Metabolism Pathway
Tree Number: T4.7.3.5
database_cross_reference: NCI:C91325
database_cross_reference: NCI_BioC:C91325

Fructose and Mannose Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014555
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Fructose and Mannose Metabolism
Tree Number: T4.7.3.6
database_cross_reference: NCI:C38810
database_cross_reference: NCI_KEGG:C38810

Galactose Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014556
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Galactose Metabolism
Synonym: galactose metabolic process
Synonym: galactose metabolism
Tree Number: T4.7.3.7
database_cross_reference: GO:GO:0006012
database_cross_reference: NCI:C38811
database_cross_reference: NCI_KEGG:C38811

Glycolysis Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
definition: In glycolysis, the six-carbon sugar glucose is oxidized and split in two halves, to create two molecules of pyruvate (3 carbons each) from each molecule of glucose. Along the way, the cell extracts a relatively small amount of energy from glucose in the form of ATP, 2 ATP molecules collected for each glucose molecule that starts down the glycolytic path. The pyruvate produced has one of three metabolic fates, to either become acetyl-CoA, ethanol, or lactate. When oxygen is available, the pyruvate can be converted to acetyl-CoA and enter the Krebs Cycle, where the acetyl-CoA will be completely oxidized and generate ATP through oxidative phosphorylation. Fermentation is much less efficient than oxidative phosphorylation in making ATP, creating only 2 ATP per glucose while oxidative phosphorylation creates 36 ATP per glucose in mammalian cells. Oxidative phosphorylation does not work in the absence of oxygen, however, and in the absence of oxygen glycolysis is forced to a halt due to a lack of NAD+, unless NAD+ is regenerated through fermentation. In mammalian muscle, strenuous exertion can create conditions in which oxygen is consumed faster than blood can provide it, forcing the muscle to use fermentation and create lactic acid; it is the lactic acid that makes your muscles sore after a workout. There are ten enzymes that catalyze the steps in glycolysis that convert glucose into pyruvate, and the entire pathway is located in the cytoplasm of eukaryotic cells. The activity of the pathway is regulated at key steps to ensure that glucose consumption and energy production match the needs of the cell. The steps along the pathway each involve a change in the free energy of the products and reactants, and as long as the overall change in free energy is negative, the reaction continues forward, like water flowing down hill to its lowest energy point. The key steps in the regulation of glycolysis, or any pathway, are those that catalyze the rate-limiting, irreversible steps …
PMOID: PMO:00014557
Subclass_of: Carbohydrate Metabolism Pathway
Tree Number: T4.7.3.8
database_cross_reference: NCI:C39095
database_cross_reference: NCI_BioC:C39095

Glycolysis/Gluconeogenesis Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
definition: Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module, which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from non-carbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths.
PMOID: PMO:00014558
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Glycolysis / Gluconeogenesis
Tree Number: T4.7.3.9
database_cross_reference: NCI:C38818
database_cross_reference: NCI_KEGG:C38818

Glyoxylate and Dicarboxylate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014559
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Glyoxylate and Dicarboxylate Metabolism
Tree Number: T4.7.3.10
database_cross_reference: NCI:C38823
database_cross_reference: NCI_KEGG:C38823

Inositol Phosphate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014560
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Inositol Metabolism
Synonym: Inositol Phosphate Metabolism
Synonym: inositol phosphate metabolic process
Synonym: inositol phosphate metabolism
Tree Number: T4.7.3.11
database_cross_reference: GO:GO:0043647
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38828
database_cross_reference: NCI_KEGG:C38828

Lactose Synthesis Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
definition: The synthesis of glycosidic bonds between monosaccharides requires energy input, energy that is provided by joining sugar monomers to a nucleotide such as UDP. Glycosyltransferases join two sugar monomers together, with UDP as the leaving group that drives the reaction forward. One glycosyltransferases is galactosyltransferase. Galactosyltransferase catalyzes the formation of a glycosidic bond between galactose and N-acetyl-D-glucosamine to create N-acetyllactosamine (D-galactosyl-N-acetyl-D-glucosamine), found in the oligosaccharides of glycoproteins. Galactosyltransferase is broadly expressed. This enzyme also catalyzes the synthesis of the disaccharide lactose, the sugar found in milk. Although this enzyme is broadly expressed, lactose production only occurs in mammary glands. Lactose production is restricted to the mammary glands because galactosyltransferase alone does not have the substrate specificity required to produce lactose. The complete lactose synthase complex includes galactosyltransferase and another non-catalytic subunit, alpha-lactalbumin. In the presence of alpha-lactalbumin, galactosyltransferase substrate specificity is switched to use glucose, resulting in lactose production rather than N-acetyllactosamine. The folding of alpha-lactalbumin, which is related to lysozyme, has been studied extensively as a model of the mechanisms involved in protein folding. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014561
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Lactose Synthesis
Synonym: lactose anabolism
Synonym: lactose biosynthesis
Synonym: lactose biosynthetic process
Synonym: lactose formation
Synonym: lactose synthesis
Tree Number: T4.7.3.12
database_cross_reference: GO:GO:0005989
database_cross_reference: NCI:C91326
database_cross_reference: NCI_BioC:C91326

Leloir Pathway of Galactose Metabolism
type: Class
subclass of: Carbohydrate Metabolism Pathway
definition: Galactose is a hexose sugar found in the disaccharide lactose. Galactose has six carbons like glucose and differs from glucose only in the stereochemistry of one carbon, C4. The enzymes of carbohydrate metabolism are specific enough that galactose must be changed to glucose before it can enter glycolysis. To convert galactose to glucose, it is first phosphorylated by galactokinase to produce galactose-1-phosphate. Galactose is then exchanged with the glucose group in UDP-glucose to create UDP-galactose and release glucose-1-phosphate. An epimerase enzyme changes the stereochemistry of C4 in UDP-galactose, creating UDP-glucose. In the next round of the transfer reaction, this glucose is released as glucose-1-phosphate. Once released, glucose-1-phosphate is converted to glucose-6-phosphate and can enter glycolysis to generate energy. Mutation of the kinase, the transferase or the epimerase can result in clinical deficiencies in galactose metabolism known as galactosemias. Galactosemias range in severity depending on the nature of the genetic change, and are usually treated through avoidance of galactose in the diet, primarily from lactose in dairy products. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014562
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Leloir pathway of galactose metabolism
Tree Number: T4.7.3.13
database_cross_reference: NCI:C39087
database_cross_reference: NCI_BioC:C39087

Oxidative Reactions of the Pentose Phosphate Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
definition: One form of chemical energy used to drive biosynthetic reactions forward is the reducing power of the energy carrier NADPH. NADPH is essential to drive the biosynthesis of fatty acids and cholesterol for example. While NADPH is an important energy carrier and is closely related to the high-energy electron carrier NADH, NADPH is distinct from NADH in several ways. NADH in oxidative phosphorylation in mitochondria transports chemical energy from the Kreb's cycle to the electron transport chain, but NADPH does not play this role. The cell keeps its pools of NADH and NADPH isolated biochemically, through the specificity of the enzymes that use and generate these cofactors. Enzymes that metabolize NADH and NADPH are highly specific for one cofactor or the other and are in different pathways. While NADH is produced in mitochondria by the Kreb's cycle, NADPH is produced through a pathway called the pentose phosphate pathway. Since one of the main purposes of this pathway is to produce NADPH for biosynthesis, this pathway occurs most predominantly in tissues like liver, fat cells, or adrenal glands that are involved in fatty acid and cholesterol biosynthesis. This pathway starts with glucose-6-phosphate, the first committed step in glycolysis, and can provide an alternative route to glycolysis for energy production. The first portion of the pentose phosphate pathway involves the oxidation of glucose in three steps, with the concomitant production of NADPH. The first step in the pentose phosphate pathway is catalyzed by glucose-6-phosphate dehydrogenase. In normal red blood cells, the NADPH produced by glucose-6-phosphate dehydrogenase is used to regenerate glutathione and protect cell membranes. Genetic deficiency in the activity of this enzyme is very common in some populations, and can result in anemias caused by fragile red blood cells. In the second and third steps, further oxidation makes more NADPH and releases carbon dioxide, shortening the sugar from six carbons to …
PMOID: PMO:00014563
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: NADPH Pathway
Synonym: Oxidative Phase of the Pentose Phosphate Pathway
Tree Number: T4.7.3.14
database_cross_reference: NCI:C91327
database_cross_reference: NCI_BioC:C91327

Pentose and Glucuronate Interconversions Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014564
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Pentose and Glucuronate Interconversions
Tree Number: T4.7.3.15
database_cross_reference: NCI:C38846
database_cross_reference: NCI_KEGG:C38846

Pentose Phosphate Cycle Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
definition: The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P.
PMOID: PMO:00014565
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Pentose Phosphate Cycle
Tree Number: T4.7.3.16
database_cross_reference: NCI:C38847
database_cross_reference: NCI_KEGG:C38847

Propanoate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014566
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Propanoate Metabolism
Tree Number: T4.7.3.17
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38854
database_cross_reference: NCI_KEGG:C38854

Pyruvate Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014567
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Pyruvate Metabolism
Synonym: pyruvate metabolic process
Synonym: pyruvate metabolism
Tree Number: T4.7.3.18
database_cross_reference: GO:GO:0006090
database_cross_reference: NCI:C38860
database_cross_reference: NCI_KEGG:C38860

Starch and Sucrose Metabolism Pathway
type: Class
subclass of: Carbohydrate Metabolism Pathway
PMOID: PMO:00014568
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Starch and Sucrose Metabolism
Tree Number: T4.7.3.19
database_cross_reference: NCI:C38867
database_cross_reference: NCI_KEGG:C38867

The Citric Acid Cycle
type: Class
subclass of: Carbohydrate Metabolism Pathway
definition: The Krebs cycle, also called the citric acid cycle, is a fundamental metabolic pathway involving eight enzymes essential for energy production through aerobic respiration, and, like glycolysis, arose early in evolution. This pathway is also an important source of biosynthetic building blocks used in gluconeogenesis, amino acid biosynthesis, and fatty acid biosynthesis. The Krebs cycle takes place in mitochondria where it oxidizes acetyl-CoA, releasing carbon dioxide and extracting energy primarily as the reduced high-energy electron carriers NADH and FADH2. NADH and FADH2 transfer chemical energy from metabolic intermediates to the electron transport chain to create a different form of energy, a gradient of protons across the inner mitochondrial membrane. The energy of the proton gradient in turn drives synthesis of the high-energy phosphate bonds in ATP, the common energy currency of the cell used to drive a huge variety of reactions and processes. An acetyl-CoA molecule (2 carbons) enters the cycle when citrate synthase condenses it with oxaloacetate (4 carbons) to create citrate (6 carbons). One source of the acetyl-CoA that enters the Krebs cycle is the conversion of pyruvate from glycolysis to acetyl-CoA by pyruvate dehydrogenase. Acetyl-CoA is a key metabolic junction, derived not only from glycolysis but also from the oxidation of fatty acids. As the cycle proceeds, the Krebs cycle intermediates are oxidized, transferring their energy to create reduced NADH and FADH2. The oxidation of the metabolic intermediates of the pathway also releases two carbon dioxide molecules for each acetyl-CoA that enters the cycle, leaving the net carbons the same with each turn of the cycle. This carbon dioxide, along with more released by pyruvate dehydrogenase, is the source of CO2 released into the atmosphere when you breathe. The Krebs cycle, like other metabolic pathways, is tightly regulated to efficiently meet the needs of the cell and the organism. The irreversible synth…
PMOID: PMO:00014569
Subclass_of: Carbohydrate Metabolism Pathway
Synonym: Citric Acid Cycle
Synonym: Citric Acid Cycles
Synonym: Citric acid cycle pathway
Synonym: Cycle, Citric Acid
Synonym: Cycle, Krebs
Synonym: Cycle, Tricarboxylic Acid
Synonym: Cycles, Citric Acid
Synonym: Cycles, Tricarboxylic Acid
Synonym: Krebs Cycle
Synonym: Krebs cycle
Tree Number: T4.7.3.20
database_cross_reference: AOD:0000001830
database_cross_reference: AOD:0000021641
database_cross_reference: CHV:0000003013
database_cross_reference: CSP:2983-8380
database_cross_reference: GO:GO:0006099
database_cross_reference: LCH_NW:sh85073260
database_cross_reference: MSH:D002952
database_cross_reference: NCI:C91329
database_cross_reference: NCI_BioC:C91329
database_cross_reference: SNMI:F-66040
database_cross_reference: SNOMEDCT_US:129911007
database_cross_reference: SNOMEDCT_US:88521006

Cofactors and Vitamins Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
PMOID: PMO:00014570
Subclass_of: Metabolic Pathway
Synonym: Metabolism of Cofactors and Vitamins - Reference Pathway
Tree Number: T4.7.4
database_cross_reference: NCI:C39733
database_cross_reference: NCI_KEGG:C39733

Biotin Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014571
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Biotin Metabolism
Synonym: biotin metabolic process
Synonym: biotin metabolism
Synonym: vitamin B7 metabolic process
Synonym: vitamin B7 metabolism
Synonym: vitamin H metabolic process
Synonym: vitamin H metabolism
Tree Number: T4.7.4.1
database_cross_reference: GO:GO:0006768
database_cross_reference: NCI:C38790
database_cross_reference: NCI_KEGG:C38790

Folate Biosynthesis Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014572
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Folate Biosynthesis
Synonym: folate biosynthesis
Synonym: folate biosynthetic process
Synonym: folic acid anabolism
Synonym: folic acid biosynthesis
Synonym: folic acid biosynthetic process
Synonym: folic acid formation
Synonym: folic acid synthesis
Synonym: vitamin B9 biosynthesis
Synonym: vitamin B9 biosynthetic process
Tree Number: T4.7.4.2
database_cross_reference: GO:GO:0046656
database_cross_reference: NCI:C38809
database_cross_reference: NCI_KEGG:C38809

Lipoic Acid Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014573
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Lipoic acid metabolism
Tree Number: T4.7.4.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91420
database_cross_reference: NCI_KEGG:C91420

Nicotinate and Nicotinamide Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014574
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Nicotinate and Nicotinamide Metabolism
Tree Number: T4.7.4.4
database_cross_reference: NCI:C38838
database_cross_reference: NCI_KEGG:C38838

One Carbon Pool by Folate Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014575
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: One Carbon Pool by Folate
Tree Number: T4.7.4.5
database_cross_reference: NCI:C38842
database_cross_reference: NCI_KEGG:C38842

Pantothenate and CoA Biosynthesis Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014576
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Pantothenate and CoA Biosynthesis
Tree Number: T4.7.4.6
database_cross_reference: NCI:C38844
database_cross_reference: NCI_KEGG:C38844

Porphyrin and Chlorophyll Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014577
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Porphyrin and Chlorophyll Metabolism
Tree Number: T4.7.4.7
database_cross_reference: NCI:C38852
database_cross_reference: NCI_KEGG:C38852

Retinol Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014578
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Retinol Metabolism
Synonym: retinol metabolic process
Synonym: retinol metabolism
Synonym: vitamin A1 alcohol metabolic process
Synonym: vitamin A1 alcohol metabolism
Synonym: vitamin A1 metabolic process
Synonym: vitamin A1 metabolism
Tree Number: T4.7.4.8
database_cross_reference: GO:GO:0042572
database_cross_reference: NCI:C38861
database_cross_reference: NCI_KEGG:C38861

Riboflavin Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014579
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Riboflavin Metabolism
Synonym: riboflavin metabolic process
Synonym: riboflavin metabolism
Synonym: vitamin B2 metabolic process
Synonym: vitamin B2 metabolism
Synonym: vitamin G metabolic process
Synonym: vitamin G metabolism
Tree Number: T4.7.4.9
database_cross_reference: GO:GO:0006771
database_cross_reference: NCI:C38862
database_cross_reference: NCI_KEGG:C38862

Thiamine Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014580
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Thiamin Metabolism
Synonym: Thiamin Metabolism Pathway
Synonym: Thiamine Metabolism
Synonym: thiamin metabolic process
Synonym: thiamin metabolism
Synonym: thiamine metabolic process
Synonym: thiamine metabolism
Synonym: vitamin B1 metabolic process
Synonym: vitamin B1 metabolism
Tree Number: T4.7.4.10
database_cross_reference: GO:GO:0006772
database_cross_reference: NCI:C38873
database_cross_reference: NCI_KEGG:C38873

Ubiquinone Biosynthesis Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
definition: Ubiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from the shikimate pathway; 4-hydroxybenzoate is directly formed from chorismate in bacteria, while it can be formed from either chorismate or tyrosine in yeast. The following biosynthesis of terpenoid moiety involves reactions of prenylation, decarboxylation, and three hydroxylations alternating with three methylations. The order of these reactions are somewhat different between bacteria and yeast. Phylloquinone (vitamin K1), menaquinone (vitamin K2), and tocopherol (vitamin E) are fat-soluble vitamins. Phylloquinone is a compound present in all photosynthetic plants serving as a cofactor for photosystem I-mediated electron transport. Menaquinone is an obligatory component of the electron-transfer pathway in bacteria.
PMOID: PMO:00014581
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Ubiquinone Biosynthesis
Synonym: Ubiquinone and menaquinone biosynthesis
Synonym: Ubiquinone and other terpenoid-quinone biosynthesis
Synonym: coenzyme Q biosynthesis
Synonym: coenzyme Q biosynthetic process
Synonym: ubiquinone anabolism
Synonym: ubiquinone biosynthesis
Synonym: ubiquinone biosynthetic process
Synonym: ubiquinone formation
Synonym: ubiquinone synthesis
Tree Number: T4.7.4.11
database_cross_reference: GO:GO:0006744
database_cross_reference: NCI:C38880
database_cross_reference: NCI_KEGG:C38880

Vitamin B6 Metabolism Pathway
type: Class
subclass of: Cofactors and Vitamins Metabolism Pathway
PMOID: PMO:00014582
Subclass_of: Cofactors and Vitamins Metabolism Pathway
Synonym: Vitamin B6 Metabolism
Tree Number: T4.7.4.12
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38885
database_cross_reference: NCI_KEGG:C38885

Degradation Pathway
type: Class
subclass of: Metabolic Pathway
definition: A sequence of biological or biochemical events that result in the catabolism of large molecules or polymers.
PMOID: PMO:00014583
Subclass_of: Metabolic Pathway
Synonym: Degradative Pathway
Tree Number: T4.7.5
database_cross_reference: NCI:C39702

Autophagy Regulation Pathway
type: Class
subclass of: Degradation Pathway
PMOID: PMO:00014584
Subclass_of: Degradation Pathway
Synonym: Regulation of autophagy
Synonym: regulation of autophagy
Tree Number: T4.7.5.1
database_cross_reference: GO:GO:0010506
database_cross_reference: NCI:C91430
database_cross_reference: NCI_KEGG:C91430

Biodegradation of Xenobiotics Pathway
type: Class
subclass of: Degradation Pathway
PMOID: PMO:00014585
Subclass_of: Degradation Pathway
Synonym: Biodegradation of Xenobiotics
Tree Number: T4.7.5.2
database_cross_reference: NCI:C39735
database_cross_reference: NCI_KEGG:C39735

Drug Metabolism by Cytochrome P450 Pathway
type: Class
subclass of: Biodegradation of Xenobiotics Pathway
PMOID: PMO:00014586
Subclass_of: Biodegradation of Xenobiotics Pathway
Synonym: Drug metabolism - cytochrome P450
Tree Number: T4.7.5.2.1
database_cross_reference: NCI:C91423
database_cross_reference: NCI_KEGG:C91423

Drug Metabolism by Non-CYP450 Enzymes Pathway
type: Class
subclass of: Biodegradation of Xenobiotics Pathway
PMOID: PMO:00014587
Subclass_of: Biodegradation of Xenobiotics Pathway
Synonym: Drug metabolism - other enzymes
Tree Number: T4.7.5.2.2
database_cross_reference: NCI:C91424
database_cross_reference: NCI_KEGG:C91424

Glucuronidation Pathway
type: Class
subclass of: Biodegradation of Xenobiotics Pathway
definition: An inactivating and detoxification pathway for a variety of exogenous and endogenous molecules, including drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids and bile acids. Glucuronic acid is highly soluble in water and is often linked to poisonous substances to allow for subsequent elimination and to hormones to allow for easier transport. Also, drugs are commonly conjugated to glucuronic acid to allow for easier delivery. Excretion occurs via urine or bile.
PMOID: PMO:00014588
Subclass_of: Biodegradation of Xenobiotics Pathway
Synonym: Glucuronidation
Tree Number: T4.7.5.2.3
database_cross_reference: NCI:C63811

Metabolism of Xenobiotics by Cytochrome P450 Pathway
type: Class
subclass of: Biodegradation of Xenobiotics Pathway
PMOID: PMO:00014589
Subclass_of: Biodegradation of Xenobiotics Pathway
Synonym: Metabolism of xenobiotics by cytochrome P450
Tree Number: T4.7.5.2.4
database_cross_reference: NCI:C91422
database_cross_reference: NCI_KEGG:C91422

Cyclin E Degradation Pathway
type: Class
subclass of: Degradation Pathway
definition: Cyclins are proteins that associate with cyclin-dependent protein kinases to regulate their activity and the progression of the cell cycle through specific checkpoints. The cyclical increase and decrease in cyclin levels is a key to cell cycle regulation. Disruption of cyclin action can lead to either cell cycle arrest, or to uncontrolled cell proliferation. When cyclin E is abundant it interacts with the cell cycle checkpoint kinase cdk2 to activate cdk2 and allow progression of the cell cycle from G1 to S phase. One of the key targets of activated cdk2 complexed with cyclin E is the tumor suppressor Rb. When dephosphorylated in G1, Rb complexes with and blocks transcriptional activation by E2F transcription factors. When Rb is phosphorylated by cdk2/Cyclin E, it dissociates from E2f, allowing E2F to activate the transcription of genes required for S phase. One of the genes activated by E2F is cyclin E itself, leading to a positive feedback cycle as cyclin E accumulates. The decision by the cell to either remain in G1 or progress into S phase is the result in part of the balance between cyclin E production and proteolytic degradation in the proteasome. Cyclin E is targeted for destruction by the proteasome through ubiquitination when associated with a complex of proteins called the SCF or F box complex. Proteins included this complex include an F box protein that targets specific substrates such as Cyclin E for degradation. In the case of cyclin E the F box protein Fbw7, also called hCdc4, associates with phosphorylated free cyclin E to recruit it into the SCF complex for degradation. SCFFbw7 is a ubiquitin ligase recruited into the complex that specifically targets cyclin E. Cul3, skp1, and Rbx1 also are part of the complex that degrades cyclin E. There may be redundancy for some components of the complex since cul1 deletion also disrupts cyclin E degradation, and multiple F box proteins may contribute to cyclin E degradation. The interaction of multiple different…
PMOID: PMO:00014590
Subclass_of: Degradation Pathway
Synonym: Cyclin E Destruction Pathway
Tree Number: T4.7.5.3
database_cross_reference: NCI:C39078
database_cross_reference: NCI_BioC:C39078

Dicer Pathway
type: Class
subclass of: Degradation Pathway
definition: The degradation of endogenous mRNA in a sequence-specific manner can be induced by dsRNA [RNA interference (RNAi)], antisense transcription, or viral infection. In the current model for posttranscriptional gene silencing by RNAi, the ribonuclease III like enzyme Dicer processes dsRNA into small fragments (siRNA) of 21-25 nts. The siRNA is incorporated into the RNA-induced silencing complex (RISC), which targets and degrades the homologous mRNA. Most of the proteins in the RISC (with the exception of Ago2 and Dicer have not been identified) but likely contain endonuclease, helicase, exonuclease and homology scanning activity. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014591
Subclass_of: Degradation Pathway
Tree Number: T4.7.5.4
database_cross_reference: NCI:C39050
database_cross_reference: NCI_BioC:C39050

E2F1 Degradation Pathway
type: Class
subclass of: Degradation Pathway
definition: E2F-1 is a transcription factor that regulates the expression of genes involved in the cell cycle and that is involved in progression of the cell cycle from G1 into S phase. Over-expression of E2F-1 can induce cellular transformation and under-expression can repress apoptosis. Association with the tumor suppressor Rb represses E2F-1 activity, and this repression is relieved when the cdk2/cyclin E complex at the G1 to S phase transition phosphorylates Rb. Like many cell cycle regulators, E2F-1 is regulated through phosphorylation by a cyclin-dependent protein kinase, cdk2/cyclin A, and by proteolytic degradation. Phosphorylation of E2F-1 by cdk2/cyclin A leads to E2F-1 inactivation, blocking DNA binding. E2F-1 is also regulated through degradation in the proteasome at the S/G2 transition. The F box complex that degrades E2F-1 contains components shared with the complexes that target other cell cycle factors for degradation. The F box protein that specifically recruits E2F for ubiquitination and degradation is Skp2. Other components of the SCF complex include Skp1, Cul1, and cdc34. Skp2 expression is cyclical, increasing in the S/G2 transition as E2F-1 is degraded. Knowledge of E2F-1 activity and its regulation form part of the complex set of interactions regulating the cell cycle and potential targets for the treatment of cancer. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014592
Subclass_of: Degradation Pathway
Synonym: E2F1 Destruction Pathway
Tree Number: T4.7.5.5
database_cross_reference: NCI:C39232
database_cross_reference: NCI_BioC:C39232

Endoplasmic Reticulum Degradation Pathway
type: Class
subclass of: Degradation Pathway
definition: The endoplasmic reticulum (ER) of the cell operates a quality control system that identifies misfolded proteins, transports them into the cytoplasm and then targets them for degradation by the proteasome. Aberrant protein degradation is the mechanism underlying many diseases, including cystic fibrosis and heritable forms of lung and liver disease. The pathways that orchestrate the destruction of aberrant proteins are collectively termed ER-associated degradation (ERAD). Most of the proteins synthesized in the ER are cotranslationally modified with N (asparagine)-linked glycans by addition of triglycosylated, branched oligosaccharides at asparagines residues. Rapid glucose trimming by ER glucosidases generates monoglucosylated N-glycans (Glc0-3Man9GlcNAc2). Productive folding of the polypeptides to which the glycans are attached requires the services of an ER lectin chaperone called calnexin (CNX) that recognize the Glc1Man9GlcNAc2 oligosaccharide and assists the folding of newly synthesized glycoproteins. Because the half-time of monoglucose in the nascent glycoproteins is about 2 min, the protein should be repeatedly reglycosylated by UDP-glucose: glycoprotein glucosyltransferase (UGGT) resulting in association with CNX. Next, the mannose residue from the middle branch of the Man9GlcNAc2 oligosaccharide is removed by ER -mannosidase I, then correctly folded glycoproteins bearing Man8GlcNAc2 isomer B (Man8B form) are transported out of the ER to the Golgi apparatus. If the native structure of the glycoprotein cannot be achieved it is retained in the ER. When substrates are released from CNX by glucosidase II, they may be transferred to one of 2 pathways: EDEM for degradation or UUGT for reentry into CNX cycle. A glycoprotein with permanent structural defects is modified by the slow-acting enzyme ER mannosidase I. This enzyme attaches Man8 glycans to misfolded glycoproteins and in so doing generates a signal that results in ER-associated glycoprotein degradation (GER…
PMOID: PMO:00014593
Subclass_of: Degradation Pathway
Synonym: ER-associated degradation (ERAD) Pathway
Tree Number: T4.7.5.6
database_cross_reference: NCI:C39288
database_cross_reference: NCI_BioC:C39288

Glycoprotein Degradation Pathway
type: Class
subclass of: Degradation Pathway
PMOID: PMO:00014594
Subclass_of: Degradation Pathway
Synonym: Glycoprotein Degradation
Synonym: Other glycan degradation
Synonym: glycoprotein breakdown
Synonym: glycoprotein catabolic process
Synonym: glycoprotein catabolism
Synonym: glycoprotein degradation
Tree Number: T4.7.5.7
database_cross_reference: GO:GO:0006516
database_cross_reference: NCI:C38820
database_cross_reference: NCI_KEGG:C38820

Limonene and Pinene Degradation Pathway
type: Class
subclass of: Degradation Pathway
PMOID: PMO:00014595
Subclass_of: Degradation Pathway
Synonym: Limonene and pinene degradation
Tree Number: T4.7.5.8
database_cross_reference: NCI:C91421
database_cross_reference: NCI_KEGG:C91421

Lysosome Assembly Pathway
type: Class
subclass of: Degradation Pathway
definition: Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
PMOID: PMO:00014596
Subclass_of: Degradation Pathway
Synonym: Lysosome
Tree Number: T4.7.5.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91440
database_cross_reference: NCI_KEGG:C91440

Proteasome Pathway
type: Class
subclass of: Degradation Pathway
definition: The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.
PMOID: PMO:00014597
Subclass_of: Degradation Pathway
Synonym: Proteasome
Synonym: proteasome pathway
Tree Number: T4.7.5.10
database_cross_reference: GO:GO:0043161
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91521
database_cross_reference: NCI_KEGG:C91521

RAR and RXR Degradation Pathway
type: Class
subclass of: Degradation Pathway
definition: Once retinoids are bound by the RAR/RXR heterodimer they became transcriptional activated. As a consequence they are degraded by the proteasome. Phosphorylation in the activation domain one (AF1) and presence of the activation domain 2 (AF2) trigger the ubiquitination of the receptors. Moreover, heterodimerization of RAR and RXR accelerate degradation of the receptors. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014598
Subclass_of: Degradation Pathway
Synonym: Degradation of the RAR and RXR by the proteasome
Tree Number: T4.7.5.11
database_cross_reference: NCI:C39215
database_cross_reference: NCI_BioC:C39215

Ubiquitin-Proteasomal Pathway
type: Class
subclass of: Degradation Pathway
definition: The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examination of these neurons in diseased tissue has revealed the presence of Lewy bodies, dense aggregates that include the protein alpha-synuclein. A genetic basis for most cases of Parkinson's disease has not yet been identified, but mutations in alpha-synuclein have been associated with at least one rare form of the disease, and mutations in another protein, the parkin gene, are associated with another inherited form of Parkinson's disease. Parkin is found in Lewy bodies along with alpha-synuclein and the parkin protein is an E3 ubiquitin ligase. Parkin appears to work in conjunction with ubiquitin activating (Uba)1, an E1 protein and the ubiquitin-conjugating (Ubc) enzymes UbcH7 and 8. The E1 delivers ubiquitin to the E2 in a cycle that creates an increasing chain of ubiquitin. The Parkin E3 ligates this onto substrates and so tags these proteins in normal cells, targeting them for destruction in the proteasome. One of the proteins that parkin normally targets for destruction is a specific O-glycosylated form of alpha-synuclein. Failure of parkin-mediated degradation of alpha-synuclein may be a key factor leading to the death of dopaminergic neurons. Another substrate of parkin is a GPCR-like protein called Pael-R that accumulates in the ER of affected cells and may cause neuronal cell death. The involvement of Parkin and alpha-synuclein mutations in genetic forms of Parkinson's suggests that failure of ubiquitination and protein degradation may be causative in other forms of Parkinson's. Questions remaining include the cause of the lack of effective ubiquitination in individuals lacking obvious genetic defects in this pathway and how to use this knowledge of ubiquitination and protein degradation in Parkinson's disease to identify therapeutic strategies. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014599
Subclass_of: Degradation Pathway
Synonym: Role of Parkin in the Ubiquitin-Proteasomal Pathway
Tree Number: T4.7.5.12
database_cross_reference: NCI:C39182
database_cross_reference: NCI_BioC:C39182

Endocytosis Pathway
type: Class
subclass of: Metabolic Pathway
definition: Endocytosis is a mechanism for cells to remove ligands, nutrients, plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
PMOID: PMO:00014600
Subclass_of: Metabolic Pathway
Synonym: Endocytosis
Tree Number: T4.7.6
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91473
database_cross_reference: NCI_KEGG:C91473

Energy Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
PMOID: PMO:00014601
Subclass_of: Metabolic Pathway
Synonym: Energy Metabolism - Reference Pathway
Tree Number: T4.7.7
database_cross_reference: NCI:C39727
database_cross_reference: NCI_KEGG:C39727

Acetyl Group Shuttle Pathway
type: Class
subclass of: Energy Metabolism Pathway
definition: Acetyl-CoA is produced in mitochondria through the metabolism of fatty acids and the oxidation of pyruvate to acetyl-CoA. When ATP is needed, this acetyl-CoA can enter the Krebs cycle to drive oxidative phosphorylation. When ATP supplies are abundant, the acetyl-CoA can be diverted to other purposes like energy storage in the form of fatty acids. The biosynthesis of fatty acids from this acetyl-CoA cannot take place directly however, since it is produced inside mitochondria while fatty acid biosynthesis occurs in the cytosol. Also, there is not a mechanism that directly transports acetyl-CoA out of mitochondria. To be transported, the acetyl-CoA must be chemically converted to citric acid using a pathway called the tricarboxylate transport system. Inside mitochondria, the enzyme citrate synthase joins acetyl-CoA with oxaloacetate to make citrate. This citrate is transported from the mitochondria to the cytosol, thus transporting the acetyl-CoA in the form of citrate. Once in the cytosol, the citrate is converted back to oxaloacetate, which is then reduced to malate. Malate can be oxidized to pyruvate by the malic enzyme, with production of NADPH as well, that can contribute to fatty acid biosynthesis. Pyruvate can be reimported back into the mitochondria. Alternatively, malate can be transported itself back into the mitochondria and used to produce NADH once inside mitochondria. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014602
Subclass_of: Energy Metabolism Pathway
Synonym: Shuttle for transfer of acetyl groups from mitochondria to the cytosol
Tree Number: T4.7.7.1
database_cross_reference: NCI:C39144
database_cross_reference: NCI_BioC:C39144

ATP Synthesis Pathway
type: Class
subclass of: Energy Metabolism Pathway
PMOID: PMO:00014603
Subclass_of: Energy Metabolism Pathway
Synonym: ATP Synthesis
Tree Number: T4.7.7.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38787
database_cross_reference: NCI_KEGG:C38787

Electron Transport Pathway
type: Class
subclass of: Energy Metabolism Pathway
definition: The body gets energy through the oxidation of food such as glucose and fatty acids. The chemical energy contained in these foods is extracted and converted until it reaches a common form, the high-energy phosphate bonds of ATP. The hydrolysis of ATP is highly favorable and is coupled to a variety of energetically unfavorable processes to drive them forward. Most of the energy of glucose or fatty acids is extracted through oxidation to produce the reduced high-energy electron carriers NADH and FADH2. From there, the energy is transferred next to the electron transport system associated with the mitochondrial inner membrane. This chain includes a series of protein complexes and non-membrane cofactors that transfer the electrons from NADH and FADH2 in a series of redox reactions from carrier to carrier. Oxygen is the final electron acceptor at the end of the chain, resulting in the production of water. The oxygen we breathe, and which is transported by hemoglobin in the blood to all of the tissues, serves this purpose and allows electron transport to occur. As the electrons pass through the chain, they transfer their energy to the complexes, which use the energy to pump protons out of the mitochondrial matrix, creating a proton gradient across the inner mitochondrial membrane. The chemical energy that started with glucose, and was transferred to NADH and FADH2, is then converted to the energy of a concentration gradient. The inner mitochondrial membrane is impermeable to protons on its own, so the energy of the proton gradient is stable, waiting to be recaptured. The energy is recaptured by ATP synthase in the inner mitochondrial membrane. This enzyme allows protons to flow back down their concentration gradient across the membrane, and in the process uses the energy of the gradient to drive ATP synthesis. The movement of the electrons through electron transport, the proton gradient and ATP synthesis are all coupled processes that require each other to occur. The cell …
PMOID: PMO:00014604
Subclass_of: Energy Metabolism Pathway
Synonym: Electron Transport Reaction in Mitochondria
Tree Number: T4.7.7.3
database_cross_reference: NCI:C39074
database_cross_reference: NCI_BioC:C39074

Feeding Amino Groups into the Urea Cycle
type: Class
subclass of: Energy Metabolism Pathway
definition: Excess amino acids in the body can be used as a source of energy, with their carbon skeleton converted to metabolic intermediates such as acetyl-CoA or intermediates in the Krebs cycle. The metabolic breakdown of amino acids releases nitrogen that must be converted to a relatively non-toxic form and then excreted. In mammals, the nitrogen is converted to urea in the liver through a series of reactions called the urea cycle. The ammonia released through the deamination of amino acids is reacted to produce carbamoyl phosphate, a reaction catalyzed by carbamoyl phosphate synthase. The enzyme ornithine transcarbamoylase is found in mitochondria and converts ornithine into citrulline. Citrulline is exported into the cytoplasm where another nitrogen for urea is acquired from aspartate, followed by the release of fumarate to form the amino acid arginine. Urea is released from arginine by the enzyme arginase, bringing the cycle back around to ornithine. The general route of entry for amino acids into the urea cycle is through transamination, the transfer of their amino group to alpha-ketoglutarate to form glutamate. The amino group from glutamate is released by glutamate dehydrogenase to create an ammonium ion. The ammonium ion is used to make carbamoyl phosphate, and ultimately urea through the urea cycle. Different amino acids can enter this pathway by different routes. The transfer of the amino group from aspartate to alpha-ketobutyrate creates oxaloacetate, a Krebs cycle intermediate. Alanine goes through transamination to release pyruvate, which can be used as fuel. Genetic defects that completely block the urea cycle are not observed in people, perhaps since such a defect would be fatal. Mutations that reduce the activity of the urea cycle have been observed, with serious affects on mental functioning and other toxicities caused by elevated levels of ammonia. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014605
Subclass_of: Energy Metabolism Pathway
Synonym: The reactions that feed amino groups into the urea cycle
Tree Number: T4.7.7.4
database_cross_reference: NCI:C91330
database_cross_reference: NCI_BioC:C91330

Malate-Aspartate Shuttle Pathway
type: Class
subclass of: Energy Metabolism Pathway
definition: Most of the energy derived from the oxidation of glucose is not extracted directly as ATP, but as reduced NADH that transfers high-energy electrons to the electron transport chain in the inner mitochondrial membrane. This NADH comes primarily from the Krebs cycle in the mitochondrial matrix and is therefore directly accessible to electron transport. NADH generated during glycolysis cannot reach the electron transport chain directly however and there is no direct mechanism for the transfer of NADH across the mitochondrial membrane. Instead shuttle mechanisms have evolved to move the energy of reduced NADH across the membrane in the form of other reduced molecules. One shuttle is the glycerophosphate shuttle and another is the malate-aspartate shuttle. The malate-aspartate shuttle occurs in mammalian tissues. First, oxaloacetate on the cytoplasmic side is reduced by NADH, creating malate and NAD+. Malate and the electrons it carries are transported into the mitochondria across the inner mitochondrial membrane, in exchange for alpha-ketoglutarate, which is transported out of the mitochondria. Once inside, the energy in malate is extracted again by reducing NAD+ to make NADH, regenerating oxaloacetate. This NADH is then free to transfer its high energy electrons to the electron transport chain. The oxaloacetate is transaminated with glutamate to make aspartate and alpha-ketoglutarate. Aspartate is returned to the cytosol by the aspartate-glutamate transporter, which moves glutamate into the mitochondria as it transports aspartate out. The overall result is that NADH is transported into the mitochondria, and can be used to generate 3 ATP per every NADH transported in from the cytosol, a very efficient process. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014606
Subclass_of: Energy Metabolism Pathway
Synonym: Malate-aspartate shuttle
Synonym: malate aspartate shuttle
Synonym: malate-aspartate shuttle
Synonym: malate/aspartate shuttle
Synonym: malate:aspartate shuttle
Tree Number: T4.7.7.5
database_cross_reference: GO:GO:0043490
database_cross_reference: NCI:C39143
database_cross_reference: NCI_BioC:C39143

Methane Metabolism Pathway
type: Class
subclass of: Energy Metabolism Pathway
PMOID: PMO:00014607
Subclass_of: Energy Metabolism Pathway
Synonym: Methane Metabolism
Synonym: methane metabolic process
Synonym: methane metabolism
Tree Number: T4.7.7.6
database_cross_reference: GO:GO:0015947
database_cross_reference: NCI:C38835
database_cross_reference: NCI_KEGG:C38835

Nitrogen Metabolism Pathway
type: Class
subclass of: Energy Metabolism Pathway
PMOID: PMO:00014608
Subclass_of: Energy Metabolism Pathway
Synonym: Nitrogen Metabolism
Synonym: nitrogen metabolism
Tree Number: T4.7.7.7
database_cross_reference: CHV:0000041667
database_cross_reference: CSP:2078-3277
database_cross_reference: NCI:C38839
database_cross_reference: NCI_KEGG:C38839

Oxidative Phosphorylation Pathway
type: Class
subclass of: Energy Metabolism Pathway
PMOID: PMO:00014609
Subclass_of: Energy Metabolism Pathway
Synonym: ATP biosynthesis (oxidative)
Synonym: ATP cycle
Synonym: OX PHOS
Synonym: Oxidative Phosphorylation
Synonym: Oxidative Phosphorylations
Synonym: Oxidative phosphorylation
Synonym: Oxidative phosphorylation (function)
Synonym: Oxidative phosphorylation, function
Synonym: Oxidative phosphorylation, function (observable entity)
Synonym: PHOS OX
Tree Number: T4.7.7.8
database_cross_reference: AOD:0000001831
database_cross_reference: AOD:0000021642
database_cross_reference: CHV:0000009145
database_cross_reference: CSP:2304-1959
database_cross_reference: GO:GO:0006119
database_cross_reference: MSH:D010085
database_cross_reference: NCI:C38843
database_cross_reference: NCI_KEGG:C38843
database_cross_reference: SNMI:F-60320
database_cross_reference: SNOMEDCT_US:5410007

Sulfur Metabolism Pathway
type: Class
subclass of: Energy Metabolism Pathway
PMOID: PMO:00014610
Subclass_of: Energy Metabolism Pathway
Synonym: Sulfur Metabolism
Synonym: sulfur compound metabolic process
Synonym: sulfur metabolism
Synonym: sulphur metabolic process
Synonym: sulphur metabolism
Tree Number: T4.7.7.9
database_cross_reference: GO:GO:0006790
database_cross_reference: NCI:C38869
database_cross_reference: NCI_KEGG:C38869

Glycan Biosynthesis and Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
PMOID: PMO:00014611
Subclass_of: Metabolic Pathway
Synonym: Glycan Biosynthesis and Metabolism - Reference Pathway
Tree Number: T4.7.8
database_cross_reference: NCI:C39732
database_cross_reference: NCI_KEGG:C39732

Blood Group Glycolipid Biosynthesis - Lacto and Neolacto Series Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
PMOID: PMO:00014612
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Blood Group Glycolipid Biosynthesis - Lact Series
Synonym: Blood Group Glycolipid Biosynthesis - Neolact Series
Synonym: Glycosphingolipid biosynthesis - lacto and neolacto series
Tree Number: T4.7.8.1
database_cross_reference: NCI:C38791
database_cross_reference: NCI_KEGG:C38791

Ganglioside Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
PMOID: PMO:00014613
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Ganglioside Biosynthesis
Synonym: ganglioside anabolism
Synonym: ganglioside biosynthesis
Synonym: ganglioside biosynthetic process
Synonym: ganglioside formation
Synonym: ganglioside synthesis
Tree Number: T4.7.8.2
database_cross_reference: GO:GO:0001574
database_cross_reference: NCI:C38812
database_cross_reference: NCI_KEGG:C38812

Globoside Metabolism Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
PMOID: PMO:00014614
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Globoside Metabolism
Synonym: globoside metabolic process
Synonym: globoside metabolism
Tree Number: T4.7.8.3
database_cross_reference: GO:GO:0001575
database_cross_reference: NCI:C38813
database_cross_reference: NCI_KEGG:C38813

Glycosaminoglycan Biosynthesis Pathway - Chondroitin Sulfate
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
definition: Glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide units and form proteoglycans by covalently attaching to their core proteins. Chondroitin sulfate (CS) is a glycosaminoglycan with the disaccharide unit GalNAc(b1-4)GlcA(b1-3), modified with ester-linked sulfate at certain positions. Dermatan sulfate (DS) is a modified form of CS, in which a portion of D-glucuronate residues is epimerized to L-iduronates. CS and DS are linked to serine residues in core proteins via a linkage tetrasaccharide formed by the transfer of xylose and three more residues. The assembly process of CS is initiated by the transfer of N-acetylgalactosamine to the linkage tetrasaccharide. The polymerization step is catalyzed by bifunctional enzymes (chondroitin synthases) that have both b-3 glucuronosyltransferase and b1-4 N-acetylgalactosaminyltransferase activities. Chondroitin polymerization also requires the action of the chondroitin polymerizing factor. Sulfation of chondroitin in vertebrates is a complex process, with multiple sulfotransferases involved in 4-O sulfation and 6-O sulfation of N-acetylgalactosamine residues. Additional enzymes exist for epimerization of glucuronic acid to iduronic acid in DS, sulfation at the C-2 position of the uronic acids, and other patterns of sulfation found in unusual species of chondroitin.
PMOID: PMO:00014615
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Chondroitin / Heparan Sulfate Biosynthesis
Synonym: Chondroitin/Heparan Sulfate Biosynthesis Pathway
Synonym: Glycosaminoglycan Biosynthesis - Chondroitin Sulfate
Tree Number: T4.7.8.4
database_cross_reference: NCI:C38795
database_cross_reference: NCI_KEGG:C38795

Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
PMOID: PMO:00014616
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Glycosaminoglycan biosynthesis - heparan sulfate
Synonym: Heparan Sulfate Biosynthesis Pathway
Tree Number: T4.7.8.5
database_cross_reference: NCI:C91414
database_cross_reference: NCI_KEGG:C91414

Glycosaminoglycan Biosynthesis Pathway - Keratan Sulfate
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
definition: Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
PMOID: PMO:00014617
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Glycosaminoglycan Biosynthesis - Keratan Sulfate
Synonym: Keratan Sulfate Biosynthesis
Synonym: Keratan Sulfate Biosynthesis Pathway
Synonym: keratan sulfate anabolism
Synonym: keratan sulfate biosynthesis
Synonym: keratan sulfate biosynthetic process
Synonym: keratan sulfate formation
Synonym: keratan sulfate synthesis
Synonym: keratan sulphate biosynthesis
Synonym: keratan sulphate biosynthetic process
Tree Number: T4.7.8.6
database_cross_reference: GO:GO:0018146
database_cross_reference: NCI:C38830
database_cross_reference: NCI_KEGG:C38830

Glycosaminoglycan Degradation Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
PMOID: PMO:00014618
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Glycosaminoglycan Degradation
Tree Number: T4.7.8.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38821
database_cross_reference: NCI_KEGG:C38821

Glycosylation of N-linked Oligosaccarides Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
definition: The biosynthesis pathway of N-glycans is a costly system with respect to the number of enzymes that are involved in the synthesis and trimming of N-glycans. While the structural diversity of N-glycans in mature proteins in the cell surface is introduced by glycosyltransferases in the Golgi complex, the core glycans in the ER are universal from yeast to mammal and have been considered as intermediates. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014619
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Steps in the Glycosylation of Mammalian N-linked Oligosaccarides
Tree Number: T4.7.8.8
database_cross_reference: NCI:C38984
database_cross_reference: NCI_BioC:C38984

Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
definition: Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis genes result in a genetic disorder, paroxysmal nocturnal hemoglobinuria.
PMOID: PMO:00014620
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: GPI-Anchor Biosynthesis Pathway
Synonym: Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis
Tree Number: T4.7.8.9
database_cross_reference: NCI:C38822
database_cross_reference: NCI_KEGG:C38822

Lipopolysaccharide Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
PMOID: PMO:00014621
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: LPS biosynthetic process
Synonym: Lipopolysaccharide Biosynthesis
Synonym: lipopolysaccharide anabolism
Synonym: lipopolysaccharide biosynthesis
Synonym: lipopolysaccharide biosynthetic process
Synonym: lipopolysaccharide formation
Synonym: lipopolysaccharide synthesis
Tree Number: T4.7.8.10
database_cross_reference: GO:GO:0009103
database_cross_reference: NCI:C38831
database_cross_reference: NCI_KEGG:C38831

N-Glycan Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
definition: N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1-Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1-PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases, the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation.
PMOID: PMO:00014622
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: Glycoprotein Biosynthesis
Synonym: Glycoprotein Biosynthesis Pathway
Synonym: N-Glycan Biosynthesis
Synonym: N-glycan biosynthesis
Tree Number: T4.7.8.11
database_cross_reference: GO:GO:0006487
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38819
database_cross_reference: NCI_KEGG:C38819

O-Glycan Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
definition: O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
PMOID: PMO:00014623
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: O-Glycan Biosynthesis
Tree Number: T4.7.8.12
database_cross_reference: NCI:C38841
database_cross_reference: NCI_KEGG:C38841

O-Mannosyl Glycan Biosynthesis Pathway
type: Class
subclass of: Glycan Biosynthesis and Metabolism Pathway
PMOID: PMO:00014624
Subclass_of: Glycan Biosynthesis and Metabolism Pathway
Synonym: O-Mannosyl glycan biosynthesis
Tree Number: T4.7.8.13
database_cross_reference: NCI:C91412
database_cross_reference: NCI_KEGG:C91412

Lipid Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
PMOID: PMO:00014625
Subclass_of: Metabolic Pathway
Synonym: Lipid Metabolism
Synonym: Lipid Metabolism - Reference Pathway
Synonym: Lipid Metabolism Reference Pathway
Tree Number: T4.7.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39728
database_cross_reference: NCI_KEGG:C39728

alpha-Linolenic Acid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014626
Subclass_of: Lipid Metabolism Pathway
Synonym: ALA metabolism
Synonym: alpha-Linolenic acid metabolism
Synonym: alpha-linolenic acid metabolic process
Synonym: alpha-linolenic acid metabolism
Tree Number: T4.7.9.1
database_cross_reference: GO:GO:0036109
database_cross_reference: NCI:C91418
database_cross_reference: NCI_KEGG:C91418

Anandamide Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: The lipid anandamide derived from arachidonic acid binds to the cannabinoid G-protein coupled receptors CB-1 and CB-2 to exert its biological effects. The CB-1 receptor is also the site of action of the psychoactive components of marijuana, including tetrahydrocannabinol (THC), and responsible for the effects of cannabinoids to repress learning, memory, and anxiety, relieve pain and nausea, and to stimulate appetite. The CB-2 receptor is expressed mainly in cells of the immune system and appears to modulate immune functions, but not to be involved in the effects of cannabinoids in the central nervous system. In addition to the illicit use of cannabinoids as drugs of abuse, the pharmaceutical use of natural and synthetic cannabinoids is being intensely studied, including a possible role in neurodegenerative diseases. Another therapeutic approach is the pharmacological modulation of levels of the endogenous cannabinoid anandamide. Although the subject of some controversy, the most likely route for the biosynthesis of anandamide starts with the formation of phosphatidylethanolamine from arachidonic acid and ethanolamine. Phosphatidylethanolamine is converted by N-acyltransferase to the phospholipid N-arachidonoyl-phosphatidylethanolamine (NAPE) and hydrolysis by phospholipase D releases phosphatidic acid and anandamide, which binds to the cannabinoid receptors. The signal it induces is terminated in part by degradation of anandamide by anandamide hydrolase (FAAH). 2-arachidonoyl-glycerol (2-AG) and 2-arachidonoyl glyceryl ether have also been shown to bind the cannabinoid receptors, and has been suggested to be important endocannabinoids. Also complicating cannabinoid pharmacology is the suggestion that some effects of cannabinoids might be moderated by additional receptor subtypes that have not yet been identified or by the vanilloid receptors. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014627
Subclass_of: Lipid Metabolism Pathway
Synonym: Metabolism of Anandamide, an Endogenous Cannabinoid
Tree Number: T4.7.9.2
database_cross_reference: NCI:C39015
database_cross_reference: NCI_BioC:C39015

Arachidonic Acid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014628
Subclass_of: Lipid Metabolism Pathway
Synonym: arachidonic acid metabolic process
Synonym: arachidonic acid metabolism
Tree Number: T4.7.9.3
database_cross_reference: GO:GO:0019369
database_cross_reference: MTH:NOCODE

Beta-Oxidation of Fatty Acids Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: Fatty acids provide highly efficient energy storage, storing much more energy for their weight than carbohydrates like glucose. Fatty acids are stored as triglycerides in adipose tissue, in which each triglyceride molecule contains three fatty acids and one glycerol. Triglycerides form fatty droplets that exclude water and take up minimal space. Fatty acids are also more highly reduced than carbohydrates, so they provide more energy during oxidation. The efficiency of energy storage in fats is probably an important reason why animals store most of their energy as fats and only a small amount of energy as carbohydrates. When glucose levels are low during long periods between meals the enzyme glucagon secreted by the pancreas stimulates adipose lipase activity to release fatty acids from triglycerides. Epinephrine can stimulate the same activity to release energy during the fight or flight response. Once released, these fatty acids travel through the blood to other tissues such as muscle where they are oxidized to provide energy through the mitochondrial beta-oxidation pathway. Since fatty acid beta-oxidation occurs in the mitochondrial matrix, long-chain fatty acids must be actively transported from the cytoplasm into mitochondria by carnitine palmitoyltransferase. The chemical energy contained in fatty acids is released through the beta-oxidation of fatty acids in mitochondria. The beta-oxidation pathway includes four reactions that occur in repeating cycles with each fatty acid molecule. In each cycle, a fatty acid is progressively shortened by two carbons as it is oxidized and its energy captured by the reduced energy carriers NADH and FADH2. At the end of each cycle of four reactions, one acetyl-CoA two-carbon unit is released from the end of the fatty acid, which then goes through another round of beta-oxidation, continuing to oxidize and shorten even-chain fatty acids until they are entirely converted to acetyl-CoA. Fatty acids with an odd number of carbons in …
PMOID: PMO:00014629
Subclass_of: Lipid Metabolism Pathway
Synonym: Beta-Oxidation of Fatty Acids
Tree Number: T4.7.9.4
database_cross_reference: NCI:C91312
database_cross_reference: NCI_BioC:C91312

Bile Acid Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine.
PMOID: PMO:00014630
Subclass_of: Lipid Metabolism Pathway
Synonym: Bile Acid Biosynthesis
Synonym: Primary bile acid biosynthesis
Synonym: bile acid anabolism
Synonym: bile acid biosynthesis
Synonym: bile acid biosynthetic process
Synonym: bile acid formation
Synonym: bile acid synthesis
Tree Number: T4.7.9.5
database_cross_reference: GO:GO:0006699
database_cross_reference: NCI:C38789
database_cross_reference: NCI_KEGG:C38789

Biosynthesis of Unsaturated Fatty Acids Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014631
Subclass_of: Lipid Metabolism Pathway
Synonym: Biosynthesis of unsaturated fatty acids
Tree Number: T4.7.9.6
database_cross_reference: NCI:C91425
database_cross_reference: NCI_KEGG:C91425

Eicosanoid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: The eicosanoids are a family of lipophilic hormones derived from the twenty carbon fatty acid arachidonic acid. Although they are diverse in structure, many eicosanoids have roles in inflammation, including regulation of vasodilation, vascular permeability, pain, and recruitment of leukocytes. Most members of this family are rapidly metabolized near their site of synthesis, so they act locally on neighboring cells, not distant parts of the body. They are also not stored in cells, but synthesized rapidly in response to stimuli, making regulation of their synthesis a key to their activity. Many drugs act through modulating the production of eicosanoids or modulating their signaling pathways. Hormones in the eicosanoid family include the prostaglandins, thromboxanes, leukotrienes, and prostacyclins. The first step in the production of eicosanoids is the release of arachidonic acid from either diacylglycerol or phospholipids by membrane bound phospholipases in response to extracellular stimulus. Arachidonic acid has several possible fates, including oxygenation by lipoxygenases to make HPETEs (hydroperoxyeicosatetraenoic acids), or production of prostaglandin H2 by PGH2 synthase. 5-lipoxygenase acts with the membrane bound protein FLAP (five lipoxygenase activating protein) to produce the epoxide leukotriene LTA4 which is hydrolyzed to produce LTB4 or has glutathione added by a glutathione S-transferase to produce LTC4 and LTD4. A G-protein coupled receptor for LTD4, CysLT1, mediates an important component of the inflammatory response of leukotrienes on airway constriction and recruitment of leukocytes, and several marketed asthma drugs act as antagonists of the CysLT1 receptor. PGH2 synthase actually consists of two enzyme components, a cyclooxygenase and a peroxidase, and there are more than one type of cyclooxygenase, including Cox-1 and Cox-2. Recent NSAIDS acting selectively as Cox-2 inhibitors like Vioxx are widely used for the treatment of arthritis and other inf…
PMOID: PMO:00014632
Subclass_of: Lipid Metabolism Pathway
Synonym: arachidonic metabolism
Synonym: eicosanoid metabolic process
Synonym: eicosanoid metabolism
Synonym: icosanoid metabolic process
Synonym: icosanoid metabolism
Tree Number: T4.7.9.7
database_cross_reference: CSP:1130-3736
database_cross_reference: GO:GO:0006690
database_cross_reference: MTH:NOCODE

Ether Lipid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014633
Subclass_of: Lipid Metabolism Pathway
Synonym: Ether lipid metabolism
Tree Number: T4.7.9.8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91416
database_cross_reference: NCI_KEGG:C91416

Fatty Acid Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014634
Subclass_of: Lipid Metabolism Pathway
Synonym: Fatty Acid Biosynthesis (path 2)
Synonym: Fatty acid biosynthesis
Tree Number: T4.7.9.9
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38806
database_cross_reference: NCI_KEGG:C38806

Fatty Acid Elongation Pathway in Mitochondria
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014635
Subclass_of: Lipid Metabolism Pathway
Synonym: Fatty Acid Biosynthesis (path 1)
Synonym: Fatty acid elongation in mitochondria
Tree Number: T4.7.9.10
database_cross_reference: NCI:C38805
database_cross_reference: NCI_KEGG:C38805

Fatty Acid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014636
Subclass_of: Lipid Metabolism Pathway
Synonym: Fatty Acid Metabolism
Synonym: acid fatty metabolism
Synonym: acids fatty metabolism
Synonym: fatty acid metabolic process
Synonym: fatty acid metabolism
Tree Number: T4.7.9.11
database_cross_reference: CHV:0000041575
database_cross_reference: CSP:1130-3456
database_cross_reference: GO:GO:0006631
database_cross_reference: NCI:C26565
database_cross_reference: NCI:C38807
database_cross_reference: NCI_KEGG:C38807

Glycerolipid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014637
Subclass_of: Lipid Metabolism Pathway
Synonym: Glycerolipid Metabolism
Synonym: glycerolipid metabolic process
Synonym: glycerolipid metabolism
Tree Number: T4.7.9.12
database_cross_reference: GO:GO:0046486
database_cross_reference: NCI:C38816
database_cross_reference: NCI_KEGG:C38816

Glycerophospholipid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014638
Subclass_of: Lipid Metabolism Pathway
Synonym: Glycerophospholipid metabolism
Tree Number: T4.7.9.13
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91415
database_cross_reference: NCI_KEGG:C91415

Linoleic Acid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014639
Subclass_of: Lipid Metabolism Pathway
Synonym: Linoleic acid metabolism
Synonym: linoleic acid metabolic process
Synonym: linoleic acid metabolism
Tree Number: T4.7.9.14
database_cross_reference: GO:GO:0043651
database_cross_reference: NCI:C91417
database_cross_reference: NCI_KEGG:C91417

Lipid Metabolism and Toxicity Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: Nuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. However, further studies have led to the identification of lipid ligands for some of these receptors, which are responsible for lipid metabolism, storage, and elimination. One of the characteristics of these receptors is that they act by forming heterodimers with retinoid X receptor (RXR). The receptors include peroxisome proliferators-Activated receptors (PPARs) for fatty acids, liver X receptor (LCR) for oxysterols, Farnesoid X receptors (FXR) for bile acids, and steroid xenobiotic receptor/X receptor (SXR/PXR or Nsil2) for xenobiotics. Other orphan receptors also requiring RXR for its functions are vitamin D receptor (VDR) for vitamin D and retinoic acid receptor (RAR) for retinoid acids, although these receptors are not involved in lipid metabolism. Upon binding to various ligands, three classes of proteins are synthesized including lipid binding proteins, the ATP-binding cassette (ABC) transporters and cytochrome P450 member proteins which catalyze lipid anabolism, metabolism, and elimination. In addition to lipid metabolism, some members of the cytochrome P450 family genes are responsible for activation of procarcinogens, detoxification of environmental toxins, and metabolism of drugs and xenobiotics. In particular, CAR, Nsil2, and recently identified VDR are important in up-regulation of these cytochromes. Of all the human cytochrome P450 genes, only a few CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 account for most toxicity effects, specifically CYP3A is responsible for clearing approximately half of the clinically prescribed drugs. For instance, acetaminophen, one of the most commonly used drug, is toxic in high doses due to the activation of CAR and the drug's subsequent conversion to acetyl-p-benzoquinone imine (NAPQI) by CYP1A2, CYP2E1 and CYP3A. (This …
PMOID: PMO:00014640
Subclass_of: Lipid Metabolism Pathway
Synonym: Nuclear Receptors in Lipid Metabolism and Toxicity
Tree Number: T4.7.9.15
database_cross_reference: NCI:C39174
database_cross_reference: NCI_BioC:C39174

Lipid Synthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: Sterol-regulatory element binding proteins (SREBPs) play a key role in transcriptional regulation of cholesterol metabolism in response to cholesterol levels in the cell. When cholesterol is abundant in the cell, the SREBPs are retained in the ER. When cholesterol levels decrease, SREBPs are cleaved and released to act as transcription factors, binding to the promoters of genes such as the LDL receptor and HMG CoA Synthase. Binding of SREBPs to the LDL receptor promoter increases the expression of LDL receptor on the cell surface and increases the internalization of LDL from plasma, increasing cellular cholesterol levels and lowering LDL cholesterol in the plasma. Upregulation of genes such as HMG CoA synthase increases the biosynthesis of cholesterol. The SREBP proteins are cleaved and activated by two proteases, S1P (Site 1 protease) and S2P (Site 2 protease). S1P cleaves SREBP region in the ER lumen and S2P cleaves in the transmembrane region of SREBPs. Regulation by sterols is provided by SCAP. SCAP activates S1P when sterols are low, inducing SREBP activation, and does not activate S1P when sterol levels increase. Drugs acting at various steps in this process can alter cholesterol metabolism and plasma cholesterol levels that contribute to coronary heart disease. The statins such as lovastatin are drugs that inhibit cholesterol biosynthesis, lowering intracellular cholesterol levels and activating SREBP cleavage to increase LDLR expression on the cell surface. Inhibition of S1P may provide another mechanism to alter plasma cholesterol levels, as suggested by the low cholesterol levels in mice lacking the S1P gene. Ligands that bind to SCAP also lower cholesterol levels through induction of LDLR expression. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014641
Subclass_of: Lipid Metabolism Pathway
Synonym: SREBP control of lipid synthesis
Tree Number: T4.7.9.16
database_cross_reference: NCI:C39226
database_cross_reference: NCI_BioC:C39226

Omega-Oxidation of Fatty Acids Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: While the main route of fatty acid metabolism is through beta-oxidation, some minor metabolic pathways such as omega oxidation also contribute to the metabolism of fatty acids and other molecules. Omega oxidation occurs in the endoplasmic reticulum rather than the mitochondria, the site of beta-oxidation. The omega carbon in a fatty acid is the carbon furthest in the alkyl chain from the carboxylic acid. In the omega oxidation pathway, this carbon is progressively oxidized first to an alcohol and then to a carboxylic acid, creating a molecule with a carboxylic acid on both ends. The first step in the pathway is catalyzed by a cytochrome P450 mixed function oxidase and requires both oxygen and NADPH. Oxidation of the alcohol is catalyzed by an alcohol dehydrogenase and aldehyde dehydrogenase catalyzes the formation of the dicarboxylic acid. If the initial substrate was a long chain fatty acid, then the resulting dicarboxylic acid can enter the beta-oxidation pathway to be shortened at both ends of the molecule at the same time. When beta-oxidation is complete, the product is short chain dicarboxylic acids like succinate or adipate. Succinate enters the Kreb's cycle, and adipate's presence in blood or urine can be monitored to determine the degree of omega oxidation in an individual. Other molecules in addition to fatty acids can also enter the omega oxidation pathway. Other molecules with long alkyl chains also enter omega oxidation, becoming more water-soluble as a result and more easily excreted from the body. Although omega oxidation is normally a minor pathway of fatty acid metabolism, failure of beta-oxidation to proceed normally can result in increased omega oxidation activity. A lack of carnitine or carnitine palmitoyltransferase activity (see Mitochondrial Carnitine Palmitoyltransferase pathway) prevents fatty acids from entering mitochondria can lead to an accumulation of fatty acids in the cell and increased omega oxidation activity. (This definition may be…
PMOID: PMO:00014642
Subclass_of: Lipid Metabolism Pathway
Synonym: Omega Oxidation
Synonym: Omega Oxidation Pathway
Tree Number: T4.7.9.17
database_cross_reference: NCI:C91313
database_cross_reference: NCI_BioC:C91313

Oxidation of Odd-Numbered Chain Fatty Acid Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: The beta-oxidation of fatty acids in mitochondria progressively shortens fatty acids two-carbons at a time as acetyl-CoA units are removed with each round of the cycle. Fatty acids that enter beta-oxidation with an even number of carbons are converted entirely to acetyl-CoA, with the last round producing two acetyl-CoA molecules from one four carbon fatty acid. A fatty acid that enters beta-oxidation with 18 carbons, for example, will produce 9 acetyl-CoA units. Fatty acids that have an odd number of carbons present a special challenge. The last round of beta-oxidation with a five-carbon chain releases acetyl-CoA and the 3-carbon chain propionyl-CoA. Propionyl-CoA is not a common metabolic intermediate in other pathways, so it must be converted into something else to be effectively metabolized. In addition to production from fatty acids, propionyl-CoA is derived from the metabolism of several fatty acids, including isoleucine, valine and methionine. Propionyl-CoA is converted to succinyl-CoA, an intermediate in the Kreb's cycle. Propionyl-CoA has three carbons and succinyl-CoA has four carbons, so one of the first steps in this pathway is the carboxylation of propionyl-CoA with an input of energy from ATP. Mutation of propionyl-CoA carboxylase has been observed to cause a genetic condition called propionic acidemia. The rearrangement of this molecule, first between two stereoisomers, and then two structural isomers, results in succinyl-CoA. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014643
Subclass_of: Lipid Metabolism Pathway
Synonym: Conversion of Propionyl-CoA to Succinyl-CoA
Synonym: Oxidation of Odd-Numbered Chain Fatty Acid, from Propionyl-CoA to Succinyl-CoA
Tree Number: T4.7.9.18
database_cross_reference: NCI:C91314
database_cross_reference: NCI_BioC:C91314

Oxidation of Polyunsaturated Fatty Acid Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: Unsaturated fatty acids are those that contain one or more double bonds in their alkyl-chain. Polyunsaturated fats with two double bonds usually have one between carbons 9 and 10 in the alkyl chain and another three carbons away (carbons 12-13). The presence of a double bond in the fatty acid chain changes the shape of the side group, and alters membrane fluidity when present in phospholipids. Polyunsaturated fatty acids in the diet such as omega-3 fatty acids from fish oil may have a positive influence on health, reducing cardiovascular disease and cancer. The double bonds in polyunsaturated fats cannot proceed directly through beta-oxidation to generate energy. Beta-oxidation will proceed normally through the first few rounds with a polyunsaturated fat, up until the point where the beta-oxidation enzymes encounter the first double bond. The enzymes of beta-oxidation are unable to act on substrates containing a double bond between the beta and gamma carbons. To solve this problem, the enzyme enoyl-CoA isomerase moves the first double bond to a position that the beta oxidation enzymes can act on, one carbon closer to the end of the alkyl chain. Beta-oxidation can then proceed for one cycle and part of the next, until it encounters the next double bond, which usually starts at an even-numbered carbon. A reductase then reduces the fatty acid, leaving a trans-3 double bond in mammals. The enzyme 3,2 enoyl-CoA isomerase moves this double bond closer to the end of the fatty acid chain, where the fatty acid can serve as a substrate for the normal beta-oxidation enzymes to continue beta-oxidation to completion. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014644
Subclass_of: Lipid Metabolism Pathway
Synonym: Oxidation of Polyunsaturated Fatty Acid
Tree Number: T4.7.9.19
database_cross_reference: NCI:C91315
database_cross_reference: NCI_BioC:C91315

Phosphatidylcholine Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: The main components of biological membranes are phosphoglyceride lipids composed of a glycerol unit esterified to two fatty acids and a polar alcohol group. The properties of phospholipids give lipid bilayer membranes their self-organizing structure. The polar alcohol group is hydrophilic and organizes itself in the membrane facing outward toward water, while the hydrophobic fatty acid alkyl chains face inward toward other fatty acid chains. One of the primary membrane phospholipids is phosphatidylcholine, in which the polar head group is composed of phosphocholine. The biosynthesis of phosphatidylcholine and phosphatidylethanolamine follow similar routes. The first step in phosphatidylcholine is the phosphorylation of choline to make phosphocholine, which is then activated by CTP. CDP-choline reacts with diacylglycerol to produce phosphatidylcholine (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014645
Subclass_of: Lipid Metabolism Pathway
Tree Number: T4.7.9.20
database_cross_reference: NCI:C91316
database_cross_reference: NCI_BioC:C91316

Phospholipid Degradation Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014646
Subclass_of: Lipid Metabolism Pathway
Synonym: phospholipid breakdown
Synonym: phospholipid catabolic process
Synonym: phospholipid catabolism
Synonym: phospholipid degradation
Tree Number: T4.7.9.21
database_cross_reference: GO:GO:0009395
database_cross_reference: MTH:NOCODE

Plasmalogen Synthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: Plasmalogens are a class of glycerophospholipids that contain one vinyl-ester linked long chain alcohol group in place of one ester-linked fatty acid chain found in other glycerophospholipids. As with the common glycerophospholipids, the polar head group of the plasmalogens is composed of ethanolamine, serine, or choline. Plasmalogens are relatively rare in some tissues but form a significant fraction of the membranes in nervous tissue. Some of the steps in plasmalogen biosynthesis are localized in peroxisomes, and some peroxisomal disorders impair plasmalogen biosynthesis. One of the starting materials for plasmalogen biosynthesis is dihydroxyacetone phosphate from glycolysis, which is used to form the glycerol backbone of the plasmalogen. In the first step, the three-carbon backbone is esterified with a fatty acid. This fatty acid ester is then exchanged leaving an ether-linked long-chain alcohol bound. Reduction of the carbonyl on the dihydroxyacetone backbone leaves a hydroxy group to be esterified with another fatty acid side chain. The polar head group such as ethanolamine is then added, and the alcohol chain modified in the last step to form the vinyl-alcohol side chain that characterizes plasmalogens. Plasmalogens serve as a starting point for the release of arachidonic acid by phospholipase A2 and the synthesis of signaling molecules derived from arachidonic acid such as prostaglandins. One plasmalogen called PAF acts through a G-protein coupled receptor as a potent platelet activator and clotting agent. The double bond of plasmalogens makes them more sensitive to oxidation than other membrane lipids, and may help to protect cells from oxidative damage. A decrease in the abundance of plasmalogens has been observed in some neurological disorders such as Alzheimer's disease. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014647
Subclass_of: Lipid Metabolism Pathway
Synonym: Synthesis of Plasmalogens
Tree Number: T4.7.9.22
database_cross_reference: NCI:C91318
database_cross_reference: NCI_BioC:C91318

Prostaglandin and Leukotriene Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014648
Subclass_of: Lipid Metabolism Pathway
Synonym: Prostaglandin and Leukotriene Metabolism
Tree Number: T4.7.9.23
database_cross_reference: NCI:C38855
database_cross_reference: NCI_KEGG:C38855

Sphingolipid Metabolism Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014649
Subclass_of: Lipid Metabolism Pathway
Synonym: Sphingoglycolipid Metabolism
Synonym: Sphingoglycolipid Metabolism Pathway
Tree Number: T4.7.9.24
database_cross_reference: NCI:C38865
database_cross_reference: NCI_KEGG:C38865

Sphingophospholipid Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014650
Subclass_of: Lipid Metabolism Pathway
Synonym: Sphingophospholipid Biosynthesis
Tree Number: T4.7.9.25
database_cross_reference: NCI:C38866
database_cross_reference: NCI_KEGG:C38866

Steroid Hormone Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via dehydroepiandrosterone and delta4 pathway via androstenedione. The enzyme CYP17A1 is responsible for the 17,20 lyase and 17alpha-hydroxylase activities in respective pathways. (iii) Female hormones estrone and estradiol are formed from testosterone and 4-androstene-3,17-dione by oxidative removal of the C19 methyl group and subsequent aromatization of ring A. In addition to these three groups, recent studies show that there is another group, termed neurosteroids, synthesized in the brain rather than the peripheral endocrine gland.
PMOID: PMO:00014651
Subclass_of: Lipid Metabolism Pathway
Synonym: steroid hormone biosynthesis
Tree Number: T4.7.9.26
database_cross_reference: CSP:1025-7964
database_cross_reference: MTH:NOCODE

Sterol Biosynthesis Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014652
Subclass_of: Lipid Metabolism Pathway
Synonym: Steroid biosynthesis
Synonym: Sterol Biosynthesis
Synonym: sterol anabolism
Synonym: sterol biosynthesis
Synonym: sterol biosynthetic process
Synonym: sterol formation
Synonym: sterol synthesis
Tree Number: T4.7.9.27
database_cross_reference: GO:GO:0016126
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38868
database_cross_reference: NCI_KEGG:C38868

Synthesis and Degradation of Ketone Bodies Pathway
type: Class
subclass of: Lipid Metabolism Pathway
PMOID: PMO:00014653
Subclass_of: Lipid Metabolism Pathway
Synonym: Synthesis and Degradation of Ketone Bodies
Tree Number: T4.7.9.28
database_cross_reference: NCI:C38870
database_cross_reference: NCI_KEGG:C38870

Synthesis of Cardiolipin and Phosphatidylinositol Pathway
type: Class
subclass of: Lipid Metabolism Pathway
definition: Phosphoglycerides are lipids that contain glycerol with a phosphate ester on one end and two fatty acid ester side chains. Phosphoglycerides such as phosphatidylethanolamine and phosphatidylserine are the major component of lipid bilayer membranes in which their detergent-like properties help to provide membranes the quality of self-assembly. Phosphatidylglycerol is a phospholipid in which the phosphate ester on glycerol is joined to another glycerol. Phosphatidylglycerol is a precursor in the synthesis of both cardiolipin and phosphatidylinositol. In cardiolipin, two phosphatidylglycerol units are joined together. Cardiolipin was first identified in the heart, thus its name, and is abundant in the heart. Antibodies against cardiolipin have been observed in the blood of individuals with autoimmune disorders such as lupus. In mammals, cardiolipin is localized in mitochondria and may play a role in oxidative phosphorylation. Changes in cardiolipin levels with age might alter mitochondrial function and contribute to the aging process. Another derivative of phosphatidylglycerol is phosphatidylinositol in which the sugar inositol forms the phosphate ester. Inositol is an important intermediary in intracellular signaling pathways. Esterification of inositol with phosphates at various positions alters its interaction with different signaling proteins. Phosphatidylinositol can be phosphorylated at two positions to create PIP2. Hydrolysis of PIP2 by phospholipase C in response to GPCR activation releases IP3, which acts as a cytoplasmic second messenger to stimulate calcium release. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014654
Subclass_of: Lipid Metabolism Pathway
Synonym: Synthesis of Cardiolipin & Phosphatidylinositol
Tree Number: T4.7.9.29
database_cross_reference: NCI:C91317
database_cross_reference: NCI_BioC:C91317

Melanogenesis Pathway
type: Class
subclass of: Metabolic Pathway
definition: Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism.
PMOID: PMO:00014655
Subclass_of: Metabolic Pathway
Synonym: Melanogenesis
Tree Number: T4.7.10
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91468
database_cross_reference: NCI_KEGG:C91468

Metabolic Pathways of Other Amino Acids
type: Class
subclass of: Metabolic Pathway
PMOID: PMO:00014656
Subclass_of: Metabolic Pathway
Synonym: Metabolism of Other Amino Acids - Reference Pathway
Tree Number: T4.7.11
database_cross_reference: NCI:C39731
database_cross_reference: NCI_KEGG:C39731

Aminophosphonate Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
definition: Natural products containing carbon-phosphorous bonds, so-called C-P compounds, are derivatives of phosphonate and phosphinate with substitution of alkyl group for hydrogen of phosphorus-hydrogen bonds. C-P compounds have been found in many organisms, but only protists and bacteria, mostly Actinobacteria, have biosynthetic capacity. A common reaction in the biosynthetic pathway is C-P bond forming reaction from phosphoenolpyruvate (PEP) to phosphonopyruvate (PnPy) catalyzed by PEP phosphomutase. 2-Aminoethylphosphonate (AEP) is the most abundant C-P compound in the natural world. AEP derivatives include phosphonoprotein, phosphonoglycan, and phosphonolipid. Other known C-P compounds are bioactive substances used in medicine (antibiotics) and agriculture (herbicide) such as fosfomycin, FR-33289, rhizocticin, and bialaphos.
PMOID: PMO:00014657
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Aminophosphonate Metabolism
Synonym: Phosphonate and phosphinate metabolism
Synonym: aminophosphonate metabolic process
Synonym: aminophosphonate metabolism
Tree Number: T4.7.11.1
database_cross_reference: GO:GO:0033051
database_cross_reference: NCI:C38780
database_cross_reference: NCI_KEGG:C38780

Beta-Alanine Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
PMOID: PMO:00014658
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Beta-Alanine Metabolism
Synonym: beta-alanine metabolic process
Synonym: beta-alanine metabolism
Tree Number: T4.7.11.2
database_cross_reference: GO:GO:0019482
database_cross_reference: NCI:C38788
database_cross_reference: NCI_KEGG:C38788

Cyanoamino Acid Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
PMOID: PMO:00014659
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Cyanoamino Acid Metabolism
Synonym: cyanoamino acid metabolic process
Synonym: cyanoamino acid metabolism
Tree Number: T4.7.11.3
database_cross_reference: GO:GO:0033052
database_cross_reference: NCI:C38798
database_cross_reference: NCI_KEGG:C38798

D-Alanine Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
PMOID: PMO:00014660
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: D-Alanine Metabolism
Synonym: D-alanine metabolic process
Synonym: D-alanine metabolism
Tree Number: T4.7.11.4
database_cross_reference: GO:GO:0046436
database_cross_reference: NCI:C38801
database_cross_reference: NCI_KEGG:C38801

D-Arginine and D-Ornithine Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
PMOID: PMO:00014661
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: D-Arginine and D-Ornithine Metabolism
Tree Number: T4.7.11.5
database_cross_reference: NCI:C38802
database_cross_reference: NCI_KEGG:C38802

D-Glutamine and D-Glutamate Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
PMOID: PMO:00014662
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: D-Glutamine and D-Glutamate Metabolism
Tree Number: T4.7.11.6
database_cross_reference: NCI:C38803
database_cross_reference: NCI_KEGG:C38803

Glutathione Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
PMOID: PMO:00014663
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Glutathione Metabolism
Synonym: glutathione metabolic process
Synonym: glutathione metabolism
Tree Number: T4.7.11.7
database_cross_reference: CHV:0000055346
database_cross_reference: GO:GO:0006749
database_cross_reference: NCI:C38815
database_cross_reference: NCI_KEGG:C38815

Selenoamino Acid Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
PMOID: PMO:00014664
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Selenoamino Acid Metabolism
Tree Number: T4.7.11.8
database_cross_reference: NCI:C38864
database_cross_reference: NCI_KEGG:C38864

Taurine and Hypotaurine Metabolism Pathway
type: Class
subclass of: Metabolic Pathways of Other Amino Acids
PMOID: PMO:00014665
Subclass_of: Metabolic Pathways of Other Amino Acids
Synonym: Taurine and Hypotaurine Metabolism
Tree Number: T4.7.11.9
database_cross_reference: NCI:C38871
database_cross_reference: NCI_KEGG:C38871

Mitochondrial Carnitine Palmitoyltransferase Pathway
type: Class
subclass of: Metabolic Pathway
definition: The oxidation of fatty acids is an important source of energy for ATP production in mitochondria through the entry of acetyl-CoA into the Krebs cycle. Fatty acids are oxidized inside the mitochondrial matrix but the fatty acids to be oxidized come from the cytosol. Fatty acids are activated in the cytosol by esterification with Coenzyme A (CoA) to form acyl-CoA (RCO-CoA, where R is the fatty acid acyl group). Activated medium-chain fatty acids (C8 and C10) freely diffuse into mitochondria to be oxidized but long chain fatty acids must be transported in. The transport of long chain fatty acids into mitochondria for oxidation is accomplished by the carnitine palmitoyltransferase system (CPTI and CPTII). CPTI exchanges carnitine for the CoA attached to long chain fatty acids to form a fatty acid-carnitine conjugate (RCO-carnitine). The fatty acid-carnitine is transported into the matrix by a transporter protein in the inner mitochondrial membrane. Once the fatty acid-carnitine is inside the matrix, CPTII exchanges CoA for carnitine to produce fatty acid-CoA once again, ready to enter fatty acid oxidation in the matrix to produce energy. The free carnitine is transported back out to renew the cytoplasmic pool of carnitine and allow the transfer process to continue. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014666
Subclass_of: Metabolic Pathway
Synonym: Mitochondrial Carnitine Palmitoyltransferase (CPT) System
Tree Number: T4.7.12
database_cross_reference: NCI:C39035
database_cross_reference: NCI_BioC:C39035

Neurotransmitter Biosynthesis Pathway
type: Class
subclass of: Metabolic Pathway
definition: Neurotransmitters are signaling molecules used by neurons to communicate across chemical synapses. The receptors for neurotransmitters include G-protein coupled receptors (GPCRs) and ligand-gated ion channels. The biogenic amines are neurotransmitters derived from amino acids, and include dopamine, epinephrine, GABA, histamine and serotonin. For each of these, decarboxylation of an amino acid is a key step. GABA, gamma-aminobutyric acid, is a key inhibitory neurotransmitter and is synthesized through the decarboxylation of glutamate in a single step. Glutamate is itself an abundant excitatory neurotransmitter. Histamine signals are involved in inflammation and acid secretion in the stomach, acting through GPCRs. Histamine is synthesized in a single step from the amino acid histidine through decarboxylation. Serotonin is a neurotransmitter with a large range of effects, including roles in mood and depression, and is synthesized by first adding a hydroxyl group to tryptophan, followed by decarboxylation. A common mechanism of antidepressant action is to block the reuptake of serotonin at synapses. Dopamine is involved in movement and mood and is derived from tyrosine through addition of a hydroxyl group and decarboxylation. Additional reactions create norepinephrine and epinephrine from dopamine. These molecules, also called adrenalin and noradrenalin, act on the adrenergic receptors to exert responses including alteration of blood pressure, heart rate, metabolic activity, and bronchodilation. Many common drugs such as asthma and heart pressure medications act on adrenergic receptors. Alterations in these biosynthetic pathways can lead to significant clinical consequences. For example, deficiency in tyrosine hydroxylase activity leads to a movement disorder similar to Parkinson's disease and may play a role in Parkinson's disease and the development of an autoimmune response against glutamate decarboxylase (GAD) may trigger the destruction of insulin-secreting cells a…
PMOID: PMO:00014667
Subclass_of: Metabolic Pathway
Synonym: Biosynthesis of Neurotransmitters
Tree Number: T4.7.13
database_cross_reference: NCI:C91323
database_cross_reference: NCI_BioC:C91323

Nucleotide Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
PMOID: PMO:00014668
Subclass_of: Metabolic Pathway
Synonym: Nucleotide Metabolism - Reference Pathway
Tree Number: T4.7.14
database_cross_reference: NCI:C39729
database_cross_reference: NCI_KEGG:C39729

Purine Metabolism Pathway
type: Class
subclass of: Nucleotide Metabolism Pathway
PMOID: PMO:00014669
Subclass_of: Nucleotide Metabolism Pathway
Synonym: Purine Metabolism
Tree Number: T4.7.14.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38858
database_cross_reference: NCI_KEGG:C38858

Pyrimidine Metabolism Pathway
type: Class
subclass of: Nucleotide Metabolism Pathway
PMOID: PMO:00014670
Subclass_of: Nucleotide Metabolism Pathway
Synonym: Pyrimidine Metabolism
Synonym: metabolism pyrimidines
Synonym: pyrimidine metabolism
Tree Number: T4.7.14.2
database_cross_reference: CHV:0000052624
database_cross_reference: CSP:2503-4410
database_cross_reference: GO:GO:0006206
database_cross_reference: GO:GO:0006213
database_cross_reference: GO:GO:0006220
database_cross_reference: NCI:C38859
database_cross_reference: NCI_KEGG:C38859

Peroxisome Biogenesis Pathway
type: Class
subclass of: Metabolic Pathway
definition: Peroxisomes are essential organelles that play a key role in redox signaling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
PMOID: PMO:00014671
Subclass_of: Metabolic Pathway
Synonym: Peroxisome
Tree Number: T4.7.15
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91498
database_cross_reference: NCI_KEGG:C91498

Regulation of Cholesterol Metabolism Pathway
type: Class
subclass of: Metabolic Pathway
definition: Cholesterol is essential for life but a key in the development of heart disease. Cholesterol homeostasis is achieved through regulation of cholesterol uptake, cholesterol biosynthesis, cholesterol conversion to bile acids and excretion of bile acids. Inhibition of cholesterol biosynthesis up regulates LDLR expression and is the mechanism of action of many drugs used to lower plasma LDL to reduce coronary heart disease. Many aspects of cholesterol homeostasis are regulated by the nuclear receptors FXR and LXR, both nuclear receptor transcription factors that form heterodimers with the retinoic acid RXR receptors and that are activated by cholesterol metabolites. One of the primary tissues in cholesterol metabolism is the liver, a key site of cholesterol biosynthesis and where cholesterol low-density lipoprotein (LDL) is taken up from the plasma by the LDL-receptor. When cholesterol accumulates in liver cells, some of the cholesterol is oxidized to create oxysterols. Oxysterols activate LXR through LXR/RXR heterodimers to activate genes such as the CYP7A1 enzyme that catalyzes the rate-limiting step in bile acid biosynthesis and a major route for the elimination of cholesterol. Animals lacking the CYP7A1 enzyme accumulate cholesterol in the liver. In the intestine LXR activates the ABC-1 gene, a transporter that actively transports cholesterol out of cells to clear it from the body. Activation of ABC-1 expression by LXR in macrophages in atherosclerotic plaques appears to be another mechanism by which LXR plays a role in heart disease. The FXR receptor is activated by bile acids. In the liver, activation of FXR-RXR heterodimers by bile acids results in the feedback inhibition of CYP7A expression and reduced biosynthesis of bile acids. In the intestine, FXR activates expression of I-BABP, a protein that increases the transport of bile acids back to the liver from the intestine, reducing their excretion. Drugs targeting the FXR and LXR receptors could play an important …
PMOID: PMO:00014672
Subclass_of: Metabolic Pathway
Synonym: FXR and LXR Regulation of Cholesterol Metabolism
Tree Number: T4.7.16
database_cross_reference: NCI:C39085
database_cross_reference: NCI_BioC:C39085

Ribosomal Biogenesis Pathway
type: Class
subclass of: Metabolic Pathway
definition: Cyclin-dependent kinase inhibitor-2A (CDKN2A) goes by the colloquial designation p16, which is sometimes referred to as p16(INK4). The alpha transcript of CDKN2A has been shown to encode p16(INK4a), a recognized tumor suppressor that induces a G1 cell cycle arrest by inhibiting the phosphorylation of the RB protein by the cyclin-dependent kinases CDK4 and CDK6. The beta transcript of CDKN2A encodes p14(ARF). The predicted 132-amino acid p14(ARF) is shorter than the corresponding mouse protein, p19(ARF), and the 2 proteins share only 50% identity. However, both proteins have the ability to elicit a p53 response, manifest in the increased expression of both CDKN1A and MDM2, and resulting in a distinctive cell cycle arrest in both the G1 and G2/M phases. Two unrelated proteins encoded by the INK4A-ARF locus function in tumor suppression. ARF binds to MDM2 and promotes the rapid degradation of MDM2. This interaction is mediated by the E1-beta-encoded N-terminal domain of ARF and a C-terminal region of MDM2. ARF-promoted MDM2 degradation is associated with MDM2 modification and concurrent p53 stabilization and accumulation. The p19(Arf) tumor suppressor inhibits production of ribosomal RNA, retarding processing of 47/45S and 32S precursors. These effects correlate with but do not strictly depend upon inhibition of rRNA biosynthesis or cell cycle arrest, are not mimicked by p53, and require neither p53 nor Mdm2. Arf mutants lacking conserved amino acid residues 2-14 do not block rRNA synthesis and processing or inhibit cell proliferation. Evolution may have linked a primordial nucleolar Arf function to Mdm2 and p53, creating a more efficient checkpoint-signaling pathway for coordinating ribosomal biogenesis and cell cycle progression. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014673
Subclass_of: Metabolic Pathway
Synonym: Tumor Suppressor Arf Inhibits Ribosomal Biogenesis
Tree Number: T4.7.17
database_cross_reference: NCI:C38992
database_cross_reference: NCI_BioC:C38992

Regulatory Pathway
type: Class
subclass of: Biochemical Pathway
definition: An elaboration of the known or inferred interactions controlling the expression of a product.
PMOID: PMO:00014674
Subclass_of: Biochemical Pathway
Tree Number: T4.8
database_cross_reference: NCI:C19779

Angiogenesis Pathway
type: Class
subclass of: Regulatory Pathway
definition: Vascular endothelial growth factor (VEGF) plays a key role in physiological blood vessel formation and pathological angiogenesis such as tumor growth and ischemic diseases. Hypoxia is a potent inducer of VEGF in vitro. The increase in secreted biologically active VEGF protein from cells exposed to hypoxia is partly because of an increased transcription rate, mediated by binding of hypoxia-inducible factor-1 (HIF1) to a hypoxia responsive element in the 5'-flanking region of the VEGF gene. bHLH-PAS transcription factor that interacts with the Ah receptor nuclear translocator (Arnt), and its predicted amino acid sequence, exhibits significant similarity to the hypoxia-inducible factor 1alpha (HIF1a) product. HLF mRNA expression is closely correlated with that of VEGF mRNA. The high expression level of HLF mRNA in the O2 delivery system of developing embryos and adult organs suggests that in a normoxic state, HLF regulates gene expression of VEGF, various glycolytic enzymes, and others driven by the HRE sequence, and may be involved in development of blood vessels and the tubular system of lung. VEGF expression is dramatically induced by hypoxia due in large part to an increase in the stability of its mRNA. HuR binds with high affinity and specificity to the VRS element that regulates VEGF mRNA stability by hypoxia. In addition, an internal ribosome entry site (IRES) ensures efficient translation of VEGF mRNA even under hypoxia. The VHL tumor suppressor (von Hippel-Lindau) regulates also VEGF expression at a post-transcriptional level. The secreted VEGF is a major angiogenic factor that regulates multiple endothelial cell functions, including mitogenesis. Cellular and circulating levels of VEGF are elevated in hematologic malignancies and are adversely associated with prognosis. Angiogenesis is a very complex, tightly regulated, multistep process, the targeting of which may well prove useful in the creation of novel therapeutic agents. Current approaches being investig…
PMOID: PMO:00014675
Subclass_of: Regulatory Pathway
Synonym: VEGF, Hypoxia, and Angiogenesis
Tree Number: T4.8.1
database_cross_reference: NCI:C39264
database_cross_reference: NCI_BioC:C39264

Apoptosis Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: A representation of the sequence of biological or biochemical events that are involved in the regulation of or result in apoptosis.
PMOID: PMO:00014676
Subclass_of: Regulatory Pathway
Tree Number: T4.8.2
database_cross_reference: NCI:C39699

AIF Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others that are caspase independent. Like cytochrome C, AIF (apoptosis-inducing factor) is a protein found in mitochondria that is released from mitochondria by apoptotic stimuli. While cytochrome C is linked to caspase-dependent apoptotic signaling, AIF release stimulates caspase-independent apoptosis, moving into the nucleus where it binds DNA. DNA binding by AIF stimulates chromatin condensation, and DNA fragmentation, perhaps through recruitment of nucleases. DNA-binding by AIF occurs through a distinct domain of the protein in a manner that does not rely on specific DNA sequences. AIF also has another domain that acts as an NADH oxidase, a redox enzyme. The NADH oxidase activity of AIF is separable from its DNA-binding activity and is not required for AIF to induce apoptosis. In this role, AIF protects against apoptosis rather than inducing apoptosis. In mice down regulation of the AIF gene created harlequin mice with oxidative damage to neurons and increased neuronal cell death. Loss of AIF also increased sensitivity to peroxides, suggesting that AIF may act as a peroxide scavenger. The mechanism by which AIF protects against peroxide damage is not clear, but may involve a more indirect mechanism than direct peroxide scavenging since the enzyme does not appear to have this activity in vitro. Elucidating further the role of AIF as a redox enzyme will shed further light on its normal function in mitochondria as well as its role in apoptosis and disease. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014677
Subclass_of: Apoptosis Regulation Pathway
Synonym: Opposing roles of AIF in Apoptosis and Cell Survival
Tree Number: T4.8.2.1
database_cross_reference: NCI:C38977
database_cross_reference: NCI_BioC:C38977

Apoptosis DNA Damage Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: The cellular activation of the caspase cascade resulting in cell death is triggered by chemical damage to DNA which stimulates a sequence resulting in the cleavage of BID or directly initiates the permeability transition of the mitochondrial membrane. The permeability transition releases several factors including cytochrome c, AIF and other factors in to the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase cascade. The caspases are a class of cysteine proteases that includes several representatives involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014678
Subclass_of: Apoptosis Regulation Pathway
Synonym: Apoptotic Signaling in Response to DNA Damage
Tree Number: T4.8.2.2
database_cross_reference: NCI:C39028
database_cross_reference: NCI_BioC:C39028

Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis.
PMOID: PMO:00014679
Subclass_of: Apoptosis Regulation Pathway
Synonym: Apoptosis
Synonym: Apoptosis (morphologic abnormality)
Synonym: Apoptotic Process
Synonym: Gene-directed cell death
Synonym: Mechanism that allows cells to self-destruct when it is necessary
Synonym: PCD
Synonym: Programmed Cell Death
Synonym: Programmed Cell Death, Type I
Synonym: RCD
Synonym: apoptose
Tree Number: T4.8.2.3
database_cross_reference: AOD:0000002370
database_cross_reference: CHV:0000017920
database_cross_reference: CSP:4001-0010
database_cross_reference: GO:GO:0006915
database_cross_reference: GO:GO:0012501
database_cross_reference: GO:GO:0097194
database_cross_reference: LCH_NW:sh91000743
database_cross_reference: MDR:10059512
database_cross_reference: MSH:D017209
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C17557
database_cross_reference: NCI:C38784
database_cross_reference: NCI_KEGG:C38784
database_cross_reference: NCI_NCI-GLOSS:CDR0000046524
database_cross_reference: NCI_NCI-GLOSS:CDR0000407582
database_cross_reference: SNMI:M-54250
database_cross_reference: SNOMEDCT_US:20663007

Apoptotic DNA Fragmentation Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: Apoptotic cell death can be triggered by many different cellular stimuli, resulting in activation of apoptotic signaling pathways including caspases and mitochondria. A cellular response that is characteristic of apoptosis is fragmentation of the nuclear genome to create a nucleosomal ladder. This activity is conducted by multiple nucleases activated by apoptotic signaling pathways. One nuclease involved in apoptosis is DNA fragmentation factor (DFF), a caspase-activated DNAse (CAD). DFF/CAD is activated through cleavage of its associated inhibitor ICAD by caspases proteases during apoptosis. DFF/CAD interacts with chromatin components such as topo II and histone H1 to condense chromatin structure and perhaps recruit CAD to chromatin. Another apoptosis activated protease is endonuclease G, EndoG. EndoG is encoded in the nuclear genome but is localized to mitochondria in normal cells. EndoG may play a role in the replication of the mitochondrial genome, as well as in apoptosis. Apoptotic signaling causes the release of EndoG from mitochondria. Mitochondria are involved in apoptotic signaling in other ways as well, through the release of cytochrome c induced by Bid to activate the caspase protease cascade. These pathways are independent since the EndoG pathway still occurs in cells lacking DFF. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014680
Subclass_of: Apoptosis Regulation Pathway
Synonym: Apoptotic DNA fragmentation and tissue homeostasis
Tree Number: T4.8.2.4
database_cross_reference: NCI:C39051
database_cross_reference: NCI_BioC:C39051

Caspase Cascade in Apoptosis
type: Class
subclass of: Apoptosis Regulation Pathway
PMOID: PMO:00014681
Subclass_of: Apoptosis Regulation Pathway
Tree Number: T4.8.2.5

Caspase Cascade Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: Apoptosis, programmed cell death, is triggered by a variety of stimuli, including cell surface receptors like FAS, mitochondrial response to stress, and cytotoxic T cells. Caspases are a class of cysteine proteases that includes several representatives involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death. The caspases at the upper end of the cascade include caspase-8 and caspase-9. Caspase-8 is the initial caspase involved in response to receptors with a death domain like FAS. The mitochondrial stress pathway begins with the release of cytochrome c from mitochondria, which then interacts with Apaf-1, causing self-cleavage and activation of caspase-9. Caspase-3, -6, and -7 are downstream caspases that are activated by the upstream proteases and act themselves to cleave cellular targets. Granzyme B and perforin proteins released by cytotoxic T cells induce apoptosis in target cells, forming transmembrane pores, and triggering apoptosis, perhaps through cleavage of caspases, although caspase-independent mechanisms of Granzyme B mediated apoptosis have been suggested. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014682
Subclass_of: Apoptosis Regulation Pathway
Synonym: Caspase Activation Cascade in Apoptosis
Synonym: Caspase Cascade in Apoptosis
Synonym: Caspase cascade in apoptosis
Tree Number: T4.8.2.6
database_cross_reference: NCI:C39014
database_cross_reference: NCI:C91560
database_cross_reference: NCI_BioC:C39014
database_cross_reference: NCI_PID:C91560

Dentatorubropallidoluysian Atrophy (DRPLA) Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
PMOID: PMO:00014683
Subclass_of: Apoptosis Regulation Pathway
Synonym: Dentatorubropallidoluysian Atrophy (DRPLA)
Tree Number: T4.8.2.7
database_cross_reference: NCI:C38804
database_cross_reference: NCI_KEGG:C38804

DR3 and DR4/5 Mediated Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: Apoptosis is specifically induced via signaling through a family of receptors known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. Apo3L recruits initiator caspase 8 via the adapter protein FADD. Caspase 8 then oligomerizes and is activated via autocatalysis. Activated caspase 8 stimulates apoptosis via two parallel cascades: it directly cleaves and activates caspase-3, and it cleaves Bid (a Bcl-2 family protein). Truncated Bid (tBid) translocates to mitochondria, inducing cytochrome C release, which sequentially activates caspases 9 and 3. DR-3L can deliver pro- or anti-apoptotic signals. DR-3 promotes apoptosis via the adaptor proteins TRADD/FADD and the activation of caspase 8. Alternatively, apoptosis is inhibited via an adaptor protein complex including RIP which activates NF-kB and induces survival genes including IAP. Induction of apoptosis via Apo2L requires caspase activity, but the adaptor requirement is unclear. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014684
Subclass_of: Apoptosis Regulation Pathway
Synonym: Induction of apoptosis through DR3 and DR4/5 Death Receptors
Tree Number: T4.8.2.8
database_cross_reference: NCI:C39049
database_cross_reference: NCI_BioC:C39049

Erythropoietin Neuroprotection Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: Erythropoietin (Epo) is most commonly known as the cytokine secreted by the kidneys that stimulates red blood cell production and is used as a drug for the treatment of anemias. Epo is also secreted in the brain in response to hypoxia, such as ischemic stroke. Epo production in the brain is stimulated by the hypoxia-inducible transcription factor HIF-1 (see HIF pathway). Administration of Epo to the brain in rodents before hypoxic stress or other neuronal stresses is neuroprotective, preventing neuronal apoptosis. The erythropoietin receptor (EpoR) is known to associate with JAK kinases that phosphorylate and activate the STAT family of transcription factors. The neuroprotection by Epo involves cross-talk between Epo receptor and anti-apoptotic pathways through activation of NF-kB by the JAK2 kinase. Epo stimulates JAK2 phosphorylation of I-kB, releasing NF-kB to translocate into the nucleus and activate transcription of neuroprotective genes. Neuroprotective genes activated by NF-kB include the anti-oxidant enzyme manganese superoxide dismutase and calbindin-D28k. The erythropoietin receptor is also essential for proper brain development in mice. The absence of EpoR causes high levels of neuronal apoptosis in the developing mouse brain, further confirming the important role of Epo as a neuroprotective agent. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014685
Subclass_of: Apoptosis Regulation Pathway
Synonym: Erythropoietin mediated neuroprotection through NF-kB
Tree Number: T4.8.2.9
database_cross_reference: NCI:C39066
database_cross_reference: NCI_BioC:C39066

Free Radical Induced Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: Oxidative stress is one factor that can trigger programmed cell death. Activated neutrophils responding to inflammatory stimulation produce reactive oxygen species like superoxide free radicals to kill invading bacteria, but these reactive oxygen species can also attack endothelial cells lining the vascular wall and trigger apoptosis. Endothelial cells also produce reactive oxygen species inside the cell that can contribute to oxidative stress and apoptosis, such as during reperfusion injury following ischemia. Superoxide dismutase (SOD) converts highly reactive and damaging superoxide free radicals to peroxides that are less reactive than superoxide but stimulate apoptosis. The glutathione (GSH) peptide reducing agent removes toxic metabolites and repairs damage created by reactive oxygen species. Glutathione peroxidase (GPx), for example, removes peroxides using glutathione as a reducing agent, and glutathione reductase (GSR) regenerates reduced glutathione. Inside the endothelial cell peroxide can be converted to hydroxyl ions in the presence of iron. Peroxides and hydroxyl radicals activate NF-kB and activate expression of inflammatory genes including adhesion molecules, TNF and IL-8. The apoptotic response of endothelial cells to oxidative stress may be involved in the development and progression of atherosclerosis. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014686
Subclass_of: Apoptosis Regulation Pathway
Synonym: Free Radical Induced Apoptosis
Tree Number: T4.8.2.10
database_cross_reference: NCI:C39084
database_cross_reference: NCI_BioC:C39084

Granzyme A Mediated Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: One mechanism used by cytotoxic T cells to kill tumor cells and virus-infected cells is the release of perforin and granzyme proteins. Perforin proteins form pores in the membranes of the attacked cell, allowing the entry of Granzyme A and Granzyme B. Granzyme B induces caspase activation and cleavage of factors like ICAD, releasing DFF40 to fragment DNA, one of the hallmarks of apoptotic cell death. Granzyme A is also an abundant granzyme released by cytotoxic T cells and is important in cytotoxic T cell induced apoptosis, activating caspase independent pathways. Once in a cell, Granzyme A activates DNA nicking by the recently identified DNAse NM23-H1, a tumor suppressor gene product whose expression is reduced in transformed, metastatic cells. The previous identification of NM23-H1 as a tumor suppressor indicates that its DNAse activity plays an important role in immune surveillance to prevent cancer through the induction of tumor cell apoptosis. The activation of NM23-H1 occurs indirectly, through the cleavage of proteins that inhibit NM23-H1 in the SET complex, which includes SET, Ape1, pp32 and HMG2. SET is a substrate for the Granzyme A protease, and SET cleavage relieves NM23-H1 inhibition to cause apoptotic DNA degradation. In addition to inhibiting NM23-H1, SET has nucleosome assembly activity and also may help the interaction of transcriptional regulation with chromatin structure by interacting with the transcriptional coactivator CBP. The targets of Granzyme A found in the SET complex also have other important functions. Ape1 repairs oxidative DNA damage, reduces transcription factors involved in immediate early responses, and its cleavage by Granzyme A may contribute to DNA degradation and apoptosis. HMG2 is an acidic chromatin-associated protein that bends DNA, alters chromatin structure and alters the accessibility of genes for transcription. In addition to acting as a nucleosome assembly factor and an inhibitor of NM23-H1, SET inhibits DNA and histone…
PMOID: PMO:00014687
Subclass_of: Apoptosis Regulation Pathway
Synonym: Granzyme A mediated Apoptosis Pathway
Tree Number: T4.8.2.11
database_cross_reference: NCI:C39230
database_cross_reference: NCI_BioC:C39230

HIV Induced T Cell Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be caused by HIV-induced apoptosis of both infected and uninfected helper T cells. HIV uses the CCR5 chemokine receptor as a coreceptor for macrophage cell entry and upregulates fas-ligand on these cells. CD4 on helper T cells is essential for viral cell entry and infection. Cross-linking of CD4 on the T cell surface may be involved in upregulation of Fas and sensitization of T cells to apoptosis induced by the Fas/Fas-ligand interaction. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014688
Subclass_of: Apoptosis Regulation Pathway
Synonym: HIV Induced T Cell Apoptosis
Tree Number: T4.8.2.12
database_cross_reference: NCI:C39244
database_cross_reference: NCI_BioC:C39244

HIV-I Nef in Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: HIV infection leads to drastic declines in CD4 T helper cells, in part through apoptosis of uninfected cells. Apoptosis of uninfected cells may be induced through the expression of Fas ligand on the surface of HIV-infected cells, stimulating the Fas-dependent apoptotic pathway in cells that come in contact with infected cells. The NEF protein expressed by HIV may play a role in the inducing the expression of Fas-ligand by infected cells. If this is the case, then a question that arises is how infected cells themselves escape Fas-mediated apoptosis. The NEF protein appears to play a role in this process as well. NEF interacts with the ASK1 kinase (apoptosis signal-regulating kinase) involved in apoptotic signaling by TNF and Fas-ligand. Interaction of NEF with ASK1 prevents phosphorylation of downstream MAP kinases and JNK kinases involved in apoptotic signaling. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014689
Subclass_of: Apoptosis Regulation Pathway
Synonym: HIV-I Nef: negative effector of Fas and TNF
Tree Number: T4.8.2.13
database_cross_reference: NCI:C39106
database_cross_reference: NCI_BioC:C39106

IGF1R Antiapoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: IGF-1R, the type 1 receptor for insulin-like growth factor, mediates cell survival and growth in response to its ligands IGF-1 and IGF-2. This tyrosine kinase receptor is widely expressed in many cell types and is a key mediator of growth. Overexpression or activation of IGF-1R may be involved in the proliferation of transformed cells, making inhibition of IGF-1R signaling a strategy for the development of cancer drugs. IGF-1R activates three signaling pathways that converge to phosphorylate BAD protein and block apoptosis. The first pathway activated by IGF-1R stimulates PI3-kinase and the AKT pathway to phosphorylate BAD and block apoptosis. A second pathway activated by IGF-1R involves ras mediated activation of the map kinase pathway to block apoptosis. A third pathway involves interaction of raf with mitochondria in response to IGF-1R activation. The convergence of these pathways to block apoptosis may enhance the IGF-1R response. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014690
Subclass_of: Apoptosis Regulation Pathway
Synonym: Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
Tree Number: T4.8.2.14
database_cross_reference: NCI:C39115
database_cross_reference: NCI_BioC:C39115

Nerve Growth Factor Receptor Signaling Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
PMOID: PMO:00014691
Subclass_of: Apoptosis Regulation Pathway
Synonym: p75(NTR) Signaling Pathway
Synonym: p75(NTR)-mediated signaling
Tree Number: T4.8.2.15
database_cross_reference: NCI:C91644
database_cross_reference: NCI_PID:C91644

Regulation of Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is less clear. Although nicotinic acetylcholine receptors are primarily known for their action as ligand-gated ion channels transducing action potentials across synapses, they may have other actions. Nicotinic acetylcholine receptors in neurons alter apoptotic signaling, protecting against cell death in some settings, and this action may in some cases be directed through alternative signaling pathways. In neurons the alpha-7 nicotinic receptor activates PI3 kinase through a src-family kinase, activating the anti-apoptotic kinase AKT (See AKT signaling pathway). One pathway involved in AKT signaling involves phosphorylation of the forkhead transcription factor FKHRL1, causing its retention in the cytoplasm associated with 14-3-3, and blocking expression of the apoptotic fas protein. The PI3 kinase/AKT pathway protects a broad range of neurons against apoptotic cell death and may block apoptosis triggered by beta-amyloid fragments that contributes to the progression of Alzheimer's disease. If so, nicotinic agents may prove useful in the treatment of this and other neurodegenerative conditions. There are several proteins that modulate the response of nicotinic acetylcholine receptors, include synapse formation. Prior to synapse formation, nicotinic receptors are randomly dispersed in the post-synaptic membrane. A neuronal protein, agrin, binds to the Musk receptor in the muscle membrane, stimulating clustering of nicotinic receptors and synapse formation. Rapsyn is present at high levels at synapses with nicotinic receptors, bringing them together at high densities and anchoring clustered receptors to the cytoskeleton. Members of the Src family of tyrosine kinases also play a role in clustering caused by Rapsyn, phosphorylating the nicotinic receptors, rapsyn, and other targets. Nicotinic receptors expressed in non-neuronal ti…
PMOID: PMO:00014692
Subclass_of: Apoptosis Regulation Pathway
Synonym: Role of nicotinic acetylcholine receptors in the regulation of apoptosis
Tree Number: T4.8.2.16
database_cross_reference: NCI:C38971
database_cross_reference: NCI_BioC:C38971

T-Cell Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: Mef2 (Myocyte enhancer factor 2) transcription factors play a role in T-Cell calcium induced apoptosis. Several factors regulate Mef2 transcription factors, including Map kinases and histone deacetylase (HDAC) enzymes. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014693
Subclass_of: Apoptosis Regulation Pathway
Synonym: Role of MEF2D in T-cell Apoptosis
Tree Number: T4.8.2.17
database_cross_reference: NCI:C39149
database_cross_reference: NCI_BioC:C39149

TSP-1 Induced Apoptosis Pathway
type: Class
subclass of: Apoptosis Regulation Pathway
definition: As tissues grow they require angiogenesis to occur if they are to be supplied with blood vessels and survive. Factors that inhibit angiogenesis might act as cancer therapeutics by blocking vessel formation in tumors and starving cancer cells. Thrombospondin-1 (TSP-1) is a protein that inhibits angiogenesis and slows tumor growth, apparently by inducing apoptosis of microvascular endothelial cells that line blood vessels. TSP-1 appears to produce this response by activating a signaling pathway that begins with its receptor, CD36, at the cell surface of the microvascular endothelial cell. The non-receptor tyrosine kinase fyn is activated by TSP-1 through CD36, activating the apoptosis inducing proteases such as caspase-3 and p38 protein kinases. p38 is a mitogen-activated kinase that also induces apoptosis in some conditions, perhaps through AP-1 activation and the activation of genes that lead to apoptosis. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014694
Subclass_of: Apoptosis Regulation Pathway
Synonym: TSP-1 Induced Apoptosis in Microvascular Endothelial Cell
Tree Number: T4.8.2.18
database_cross_reference: NCI:C39260
database_cross_reference: NCI_BioC:C39260

ATF-2 Transcription Factor Signaling Pathway
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014695
Subclass_of: Regulatory Pathway
Synonym: ATF-2 transcription factor network
Tree Number: T4.8.3
database_cross_reference: NCI:C91544
database_cross_reference: NCI_PID:C91544

BAD Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112, 136, and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway. BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kinase A inhibitors. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014696
Subclass_of: Regulatory Pathway
Synonym: Regulation of BAD phosphorylation
Tree Number: T4.8.4
database_cross_reference: NCI:C38998
database_cross_reference: NCI_BioC:C38998

Cadmium Induction Pathway
type: Class
subclass of: Regulatory Pathway
definition: Exposure to divalent cadmium ions (Cd2+) is a known cancer risk factor, but the molecular mechanisms responsible for the inappropriate induction of cellular proliferation by cadmium are still being figured out. One cellular model used to study this process is macrophages grown in culture. In cultured macrophages, cadmium acts both at the cell surface and in the cytoplasm to induce proliferation. At the cell surface, cadmium interacts with a pertussis-sensitive cell surface receptor, probably a Gi-coupled GPCR, to stimulate proliferation. Cadmium can enter cells through calcium ion channels and once in cells affects calcium release by the ER. In addition to changes in intracellular calcium, the proliferative effects of cadmium are mediated by the Ras/Map kinase pathway, and also NF-kB. Inhibition of phospholipase C, map kinases, or NF-kB with a variety of pharmacological inhibitors all blocked the activation of cellular proliferation by cadmium. Protein kinase C is also activated by cadmium, upstream of the Map kinase pathway. Changes in transcription induced by cadmium include induction of immediate early genes like fos, jun, and myc. In addition to inducing cellular proliferation, cadmium also is slightly genotoxic due to inhibition of DNA repair, activates stress genes, and inhibits the immune system. The immunomodulatory effects observed with cadmium treatment may also involvement transcriptional disregulation, including the expression of cytokines such as IL-4, IL-10, and TNF-alpha. Although macrophages have been used for many studies, other cell types are also the target of cadmium's toxicity. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014697
Subclass_of: Regulatory Pathway
Synonym: Cadmium induces DNA synthesis and proliferation in macrophages
Tree Number: T4.8.5
database_cross_reference: NCI:C39023
database_cross_reference: NCI_BioC:C39023

Calmodulin Pathway
type: Class
subclass of: Regulatory Pathway
definition: The calcium/calmodulin-dependent kinases (CaMKs) are involved in a large number of cellular responses induced by hormones, neurotransmitters and other signaling. Elevation of calcium functions as a major second messenger, where the intracellular concentration of calcium can be maintained at extremely low levels and subsequently increased following specific calcium-mobilizing stimuli. There are many buffers to the calcium fluctuations including membrane pumps and calcium-binding proteins that create discrete spatial control of its effectors and their targets. The current family of multifunctional calcium/calmodulin (CaM)-dependent protein kinases (CaMKs) consists of CaMKI, CaMKII and CaMKIV. These kinases translate and co-ordinate the calcium fluctuations into the appropriate cellular responses via phosphorylation. These kinases are partially regulated by the intracellular calcium receptor calmodulin (CaM), and have common as well as unique features in their structure, regulation and activation. CaMKII, CaMKI and CaMKIV, have an autoregulatory domain that restricts or inhibits enzymatic activity in the absence of calcium/CaM. Calcium/CaM binding alone produces maximal activity of CaMKII, whereas CaMKI and CaMKIV have an activation loop that requires phosphorylation of a threonine residue by CaMK kinase (CaMKK) for maximal activity. Two genes (alpha and beta) for CaMKK, which is also regulated by CaM, have been identified. The highest expression of these isoforms occurs in the brain but the activity of the CaMKs has been identified in most cell types. CaMKIV has a post-calmodulin autophosphorylation step that is not observed in CaMKI. The CaMKII multimer can autophosphorylate either the autoregulatory domain or the CaM-binding domain, producing diverse effects in its regulation and sensitivity to Calcium/CaM. Autophosphorylation of CaMKII can produce Calcium/CaM- independent activity (autonomous activity), without affecting its maximal Calcium/CaM-stimulated activity.…
PMOID: PMO:00014698
Subclass_of: Regulatory Pathway
Synonym: Ca++/ Calmodulin-dependent Protein Kinase Activation
Tree Number: T4.8.6
database_cross_reference: NCI:C39009
database_cross_reference: NCI_BioC:C39009

CARM1 Transcription Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014699
Subclass_of: Regulatory Pathway
Synonym: Transcription Regulation by Methyltransferase of CARM1
Tree Number: T4.8.7
database_cross_reference: NCI:C39012
database_cross_reference: NCI_BioC:C39012

CDK Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Initiation of DNA replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to restrict initiation events to once per replication origin per S phase. Its control has been uncovered by the discovery of the cyclin dependent kinases (CDKs) as master regulators of the cell cycle and the initiator proteins of DNA replication, such as the Origin Recognition Complex (ORC), Cdc6/18, Cdt1 and the mini-chromosome maintenance complex (Mcm). The proteins and the sequence of events involved in this process are conserved throughout the eukaryotic kingdom. First, the ORC comprised of six proteins binds to replication origins in the chromosomal DNA. At the end of mitosis, ORC, Cdc6/18 and Cdt1 assist the binding of Mcm proteins 2-7 to chromatin, and chromatin becomes licensed for replication. The activated Mcm complex functions as a replicating helicase and moves along with the replication fork to bring the origins to the unlicensed state. The cycling of CDK activity in the cell cycle regulates the two states of replication origins, the licensed state in G1-phase and the unlicensed state for the rest of the cell cycle. The restriction on licensing is relieved when CDK falls off at the completion of mitosis to allow a new round of replication. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014700
Subclass_of: Regulatory Pathway
Synonym: CDK Regulation of DNA Replication
Tree Number: T4.8.8
database_cross_reference: NCI:C39148
database_cross_reference: NCI_BioC:C39148

Cell Cycle Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: A representation of the sequence of biological or biochemical events that are involved in the regulation of the cell cycle.
PMOID: PMO:00014701
Subclass_of: Regulatory Pathway
Tree Number: T4.8.9
database_cross_reference: NCI:C39700

AKAP8 in Mitosis Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: Chromatin packaging of the genome is dynamic, changing with the cell cycle and with transcriptional regulation. During mitosis, chromatin is condensed for segregation of chromosomes, while for transcription chromatin is more open. The nuclear matrix, or scaffold, is a protein network in the nucleus providing structure and regulating chromatin condensation. Regulated interactions of matrix proteins with each other, DNA and other factors in different phases of the cell cycle alter the structure and function of chromatin. AKAP95 (A-kinase anchoring protein) is a nuclear matrix associated protein that also binds DNA and different proteins during different phases of the cell cycle. The interaction of AKAP95 with DNA and proteins alters the condensation and transcription of chromatin. A specific domain of AKAP95 regulates its interaction with the nuclear matrix and another regulates its association with DNA. One key protein that AKAP95 interacts with is the cAMP-dependent protein kinase, PKA. AKAP95 binds to PKA through a PKA RII regulatory subunit, an interaction that requires PKA phosphorylation by Cdk1. PKA activity and cAMP are reduced during entry into mitosis, but PKA recruited by AKAP95 to condensed chromosomes is essential to maintain the condensed state. Another protein recruited by AKAP95 is Eg7, a 150 kD protein recruited during mitotic chromatin condensation. Eg7 is a part of a multiprotein condensin complex, recruiting another key component of mitotic chromatin condensation. Modification of the core histones through phosphorylation regulates chromatin condensation. Histone H3 interacts with the condensin complex, and is phosphorylated during mitosis. Histone H3 phosphorylation by Aurora-2 induces chromatin condensation, and dephosphorylation by PP1 promotes chromatin decondensation for reentry into interphase. AKAP95 may play a role during the regulation of chromatin structure for transcription during interphase as well. The interaction of AKAP95 with the p68…
PMOID: PMO:00014702
Subclass_of: Cell Cycle Regulation Pathway
Synonym: AKAP95 role in mitosis and chromosome dynamics
Tree Number: T4.8.9.1
database_cross_reference: NCI:C38979
database_cross_reference: NCI_BioC:C38979

Aurora Kinase Signaling Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
PMOID: PMO:00014703
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Signaling by Aurora kinases
Tree Number: T4.8.9.2
database_cross_reference: NCI:C91546
database_cross_reference: NCI_PID:C91546

Aurora A Signaling Pathway
type: Class
subclass of: Aurora Kinase Signaling Pathway
PMOID: PMO:00014704
Subclass_of: Aurora Kinase Signaling Pathway
Synonym: Aurora A signaling
Tree Number: T4.8.9.2.1
database_cross_reference: NCI:C91547
database_cross_reference: NCI_PID:C91547

Aurora B Signaling Pathway
type: Class
subclass of: Aurora Kinase Signaling Pathway
PMOID: PMO:00014705
Subclass_of: Aurora Kinase Signaling Pathway
Synonym: Aurora B signaling
Tree Number: T4.8.9.2.2
database_cross_reference: NCI:C91548
database_cross_reference: NCI_PID:C91548

Aurora C Signaling Pathway
type: Class
subclass of: Aurora Kinase Signaling Pathway
PMOID: PMO:00014706
Subclass_of: Aurora Kinase Signaling Pathway
Synonym: Aurora C signaling
Tree Number: T4.8.9.2.3
database_cross_reference: NCI:C91549
database_cross_reference: NCI_PID:C91549

BTG Cell Cycle Regulation Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: BTG2 is found to be one of the immediate early genes up-regulated by neural growth factor (NGF) and epidermal growth factor (EGF). Its transcriptional level is also up-regulated by p53, gamma radiation, adriamycin, and UV treatment of cells. BTG seems to be important for the cell cycle progression as BTG2 is preferentially expressed in quiescent cells. Over-expression of BTG2 decreases the growth of NIH3T3 cells and induces neuronal differentiation and prevention apoptosis of PC12 cells. Molecularly, BTG2 expression induces hypophosphorylation of RB and G1 arrest which could be rescued by overexpression of cyclin D1. BTG1 and BTG2 interact with PRMT1 (predominant cellular arginine N-methyltransferase) and increase PRMT1 methyltransferase activity. Box C domain in BTG1 and 2 are responsible for the interaction. Box C domain alone acts as a dominant negative which blocks PRMT1 activity. PRMT1 activity is essential for NGF induced PC12 differentiation, and blocking PRMT1 by Box C domain of BTG1 or 2 induces apoptosis. In addition, BTG2 and HoxB9 interaction enhances the transcription of Hoxb9. Lastly, association of BTG2 and BTG1 with Caf1 is also reported to modulate transcriptional activity of CAF1. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014707
Subclass_of: Cell Cycle Regulation Pathway
Synonym: BTG family proteins and cell cycle regulation
Tree Number: T4.8.9.3
database_cross_reference: NCI:C39008
database_cross_reference: NCI_BioC:C39008

CDC25 and CHK1 Regulatory Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into the M-phase of the cell cycle. Cdc25 is phosphorylated throughout interphase but not in mitosis. The primary site for phosphorylation of cdc25 is Ser216. Phosphorylated cdc25 binds to members of the 14-3-3 family of proteins which prevents its activation of cdc2. Chk1, a protein kinase involved in the DNA damage checkpoint response in fission yeast, has been shown to phosphorylate cdc25 at Ser216 in vitro. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014708
Subclass_of: Cell Cycle Regulation Pathway
Synonym: cdc25 and chk1 Regulatory Pathway in response to DNA damage
Tree Number: T4.8.9.4
database_cross_reference: NCI:C39020
database_cross_reference: NCI_BioC:C39020

Cell Cycle Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
PMOID: PMO:00014709
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Cell Cycle
Synonym: Cell Cycles
Synonym: Cell Division Cycle
Synonym: Cell Division Cycles
Synonym: Cell cycle
Synonym: Cycle, Cell
Synonym: Cycle, Cell Division
Synonym: Cycles, Cell
Synonym: Cycles, Cell Division
Synonym: Division Cycle, Cell
Tree Number: T4.8.9.5
database_cross_reference: AOD:0000002348
database_cross_reference: CHV:0000002583
database_cross_reference: CSP:0600-2965
database_cross_reference: GO:GO:0007049
database_cross_reference: LCH:U000866
database_cross_reference: LCH_NW:sh85021643
database_cross_reference: MSH:D002453
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38794
database_cross_reference: NCI_KEGG:C38794

Cell Cycle Progression Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: The focus of this pathway is to illustrate the role of Polo-like Kinase 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading to apoptosis and the arrest cell cycle progression prior to M phase. Phosphorylation of Cdc25C on serine-216 causes the arrest of the cell cycle at the G2/M phase border by preventing Cdc25C from activating cyclinB1/Cdk1. Xie et al. demonstrated that Plk3, like Chk1 and Chk2, also phosphorylates Cdc25C on serine-216 contributing to cell cycle arrest. Additionally they found that Plk3 also phosphorylates p53 on serine 20, a step that is stimulatory in the process leading up to p53-mediated apoptosis. Wang Q et al. found that Plk3 is closely associated with the centrosome and that this is dependent on the integrity of the microtubules. Expression of constitutively active or defective Plk3 kinase had significant defects on the shape and nature of the microtubule apparatus of the cell. In either case cell cycle progression was halted and apoptosis occurred. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014710
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Regulation of cell cycle progression by Plk3
Tree Number: T4.8.9.6
database_cross_reference: NCI:C39195
database_cross_reference: NCI_BioC:C39195

Cyclin Regulation of Cell Cycle Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Key among these are p53, the cdk inhibitors (p15, p16, p18, p19, p21, p27), and Rb, all of which act to keep the cell cycle from progressing until all repairs to damaged DNA have been completed. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014711
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Cyclins and Cell Cycle Regulation
Tree Number: T4.8.9.7
database_cross_reference: NCI:C39025
database_cross_reference: NCI_BioC:C39025

E2F Transcription Factor Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
PMOID: PMO:00014712
Subclass_of: Cell Cycle Regulation Pathway
Synonym: E2F transcription factor network
Tree Number: T4.8.9.8
database_cross_reference: NCI:C91574
database_cross_reference: NCI_PID:C91574

EFP Cell Cycle Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: The estrogen-inducible RING finger protein Efp stimulates proliferation of breast cancer cells. 14-3-3 is p53-inducible protein that sequesters mitotic Cdks in the cytoplasm to inhibit entry into mitosis. To allow cell-cycle progression, estrogens stimulate production of Efp, which binds and ubiquinates 14-3-3s sigma. 14-3-3s marked with ubiquitin chains is recognized and destroyed by the proteasome. Released Cdks are now free to escape into the nucleus and promote mitotic entry. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014713
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
Tree Number: T4.8.9.9
database_cross_reference: NCI:C39057
database_cross_reference: NCI_BioC:C39057

G1 to S Transition Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: The cell cycle transition from G1 to S phase is a key regulatory point in the cell cycle. This transition is regulated by the checkpoint kinase cdk2 that activates the G1 to S transition when it is associated with cyclin E. Cdk2/Cyclin E causes the G1 to S transition through phosphorylation of the tumor suppressor Rb, releasing the transcription factor E2F-1. Other pathways acting through Rac, Ras, and Rho also regulate the G1 to S transition. Ras regulates cyclin D1 expression to affect the G1 to S transition. Transforming forms of Ras or Raf induce cyclin D1 expression and cause early entry into S phase. Signaling from Ras to Raf to MEK to ERKs induces Cyclin D1 expression, allowing Cyclin D1 to complex with Cdk4 and Cdk6 and phosphorylate Rb. Rac-1 and PAK appear to induce Cyclin D1 expression and induce the G1 to S transition primarily through activation of NF-kB to activate the Cyclin D1 promoter. Rho activates cdk2 and also inhibits p21 and p27 to induce cyclin D1 and stimulate the G1 to S transition. Rho represses p21 expression to block p21 induction by Ras and to allow Ras induced progression from G1 to S. Cells that lack p21 do not require Rho for Ras to induce cell cycle progression from G1 to S phase. The cooperative action of Ras, Rac and Rho to induce Cyclin D1 expression is a key component of oncogenic transformation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014714
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Influence of Ras and Rho proteins on G1 to S Transition
Tree Number: T4.8.9.10
database_cross_reference: NCI:C39210
database_cross_reference: NCI_BioC:C39210

G1/S Checkpoint Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: The G1/S cell cycle checkpoint controls the passage of eukaryotic cells from the first 'gap' phase (G1) into the DNA synthesis phase (S). Two cell cycle kinases, CDK4/6-cyclin D and CDK2-cyclin E, and the transcription complex that includes Rb and E2F are pivotal in controlling this checkpoint. During G1 phase, the Rb-HDAC repressor complex binds to the E2F-DP1 transcription factors, inhibiting downstream transcription. Phosphorylation of Rb by CDK4/6 and CDK2 dissociates the Rb-repressor complex, permitting transcription of S-phase genes encoding for proteins that amplify the G1 to S phase switch and that are required for DNA replication. Many different stimuli exert checkpoint control including TGFb, DNA damage, contact inhibition, replicative senescence, and growth factor withdrawal. The first four act by inducing members of the INK4 or Kip/Cip families of cell cycle kinase inhibitors. TGFb additionally inhibits the transcription of Cdc25A, a phosphatase that activates the cell cycle kinases. Growth factor withdrawal activates GSK3b, which phosphorylates cyclin D, leading to its rapid ubiquitination and proteasomal degradation. Ubiquitination, nuclear export, and degradation are mechanisms commonly used to rapidly reduce the concentration of cell-cycle control proteins. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014715
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Cell Cycle: G1/S Check Point
Tree Number: T4.8.9.11
database_cross_reference: NCI:C39086
database_cross_reference: NCI_BioC:C39086

G2/M Checkpoint Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: The G2/M DNA damage checkpoint prevents the cell from entering mitosis (M phase) if the genome is damaged. The Cdc2-cyclin B kinase is pivotal in regulating this transition. During G2 phase, Cdc2 is maintained in an inactive state by the kinases Wee1 and Mt1. As cells approach M phase, the phosphatase Cdc25 is activated, perhaps by the polo-kinase Pik1. Cdc25 then activates Cdc2, establishing a feedback amplification loop that efficiently drives the cell into mitosis. DNA damage activates the DNA-PK/ATM/ATR kinases, initiating two parallel cascades that inactivate Cdc2-cyclin B. The first cascade rapidly inhibits progression into mitosis: the CHK kinases phosphorylate and inactivate Cdc25, which can no longer activate Cdc2. The second cascade is slower. Phosphorylation of p53 dissociates it from MDM2, activating its DNA binding activity. Acetylation by p300/PCAF further activates its transcriptional activity. The genes that are turned on by p53 constitute effectors of this second cascade. They include 14-3-3s, which binds to the phosphorylated Cdc2-cyclin B kinase and exports it from the nucleus; GADD45, which apparently binds to and dissociates the Cdc2-cyclin B kinase; and p21Cip1, an inhibitor of a subset of the cyclin-dependent kinases including Cdc2 (CDK1). (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014716
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Cell Cycle: G2/M Checkpoint
Synonym: G2 M Cell Cycle Checkpoint
Synonym: G2-M Cell Cycle Checkpoint
Tree Number: T4.8.9.12
database_cross_reference: MSH:D059565
database_cross_reference: NCI:C39088
database_cross_reference: NCI_BioC:C39088

p27 Regulation Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: p27/Kip1 regulates the cell cycle by inhibiting the checkpoint kinase cdk2/cyclin E and blocking cell cycle progression through the G1-S transition. Cancer cells in some cases have reduced levels of p27, supporting the importance of p27 in cell cycle regulation. The activity of p27 is regulated by phosphorylation, synthesis and degradation. Phosphorylation of p27 at threonine-187 by cdk2 causes p27 to associate with an SCF complex that targets p27 for proteolytic degradation. The F box protein Skp2 binds specifically to threonine-187 phosphorylated p27, recruiting it to the SCF complex for degradation. Other components of the p27 ubiquitin ligase complex include Skp1, Cul1, and Roc1/Rbx-1. Cks-1 has also been identified in a reconstituted system as an essential component for recruitment of p27 for degradation by the SCF complex. Signaling by cytokines may modulate cell survival, proliferation, or apoptosis through modulation of p27 expression. Cytokine and AKT signaling pathways activate forkhead transcription factors that induce p27 expression at the transcriptional level. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014717
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Regulation of p27 Phosphorylation during Cell Cycle Progression
Tree Number: T4.8.9.13
database_cross_reference: NCI:C39176
database_cross_reference: NCI_BioC:C39176

p53 Signaling Pathway BioCarta
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: p53 is a transcription factor who's activity is regulated by phosphorylation. The function is p53 is to keep the cell from progressing through the cell cycle if there is damage to DNA present. It may do this in multiple ways from holding the cell at a checkpoint until repairs can be made to causing the cell to enter apoptosis if the damage cannot be repaired. The critical role of p53 is evidenced by the fact that it is mutated in a very large fraction of tumors from nearly all sources. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014718
Subclass_of: Cell Cycle Regulation Pathway
Synonym: p53 Signaling Pathway
Tree Number: T4.8.9.14
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39180
database_cross_reference: NCI_BioC:C39180

p53 Signaling Pathway KEGG
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
PMOID: PMO:00014719
Subclass_of: Cell Cycle Regulation Pathway
Synonym: p53 signaling pathway
Tree Number: T4.8.9.15
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91495
database_cross_reference: NCI_KEGG:C91495

Polo-like Kinase Signaling Pathway in the Cell Cycle
type: Class
subclass of: Cell Cycle Regulation Pathway
PMOID: PMO:00014720
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Polo-like kinase signaling events in the cell cycle
Tree Number: T4.8.9.16
database_cross_reference: NCI:C91650
database_cross_reference: NCI_PID:C91650

PLK1 Signaling Pathway
type: Class
subclass of: Polo-like Kinase Signaling Pathway in the Cell Cycle
PMOID: PMO:00014721
Subclass_of: Polo-like Kinase Signaling Pathway in the Cell Cycle
Synonym: PLK1 signaling events
Tree Number: T4.8.9.16.1
database_cross_reference: NCI:C91651
database_cross_reference: NCI_PID:C91651

PLK2 and PLK4 Signaling Pathway
type: Class
subclass of: Polo-like Kinase Signaling Pathway in the Cell Cycle
PMOID: PMO:00014722
Subclass_of: Polo-like Kinase Signaling Pathway in the Cell Cycle
Synonym: PLK2 and PLK4 events
Tree Number: T4.8.9.16.2
database_cross_reference: NCI:C91652
database_cross_reference: NCI_PID:C91652

PLK3 Signaling Pathway
type: Class
subclass of: Polo-like Kinase Signaling Pathway in the Cell Cycle
PMOID: PMO:00014723
Subclass_of: Polo-like Kinase Signaling Pathway in the Cell Cycle
Synonym: PLK3 signaling events
Tree Number: T4.8.9.16.3
database_cross_reference: NCI:C91653
database_cross_reference: NCI_PID:C91653

Ptc1 Regulation of Cell Cycle Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: Sonic Hedgehog (Shh) is a secreted protein identified genetically as an important developmental factor. Shh provides a morphogenic signal in the developing CNS, organizing the spatial patterning of cells in the midbrain and inducing proliferation of neuronal precursor cells in the developing cerebellum, neural tube, and retina. Proliferative signaling by Shh is involved in the development of cancer, including specific brain and skin cancers such as basal cell carcinomas. Sonic hedgehog signaling may proceed by more than one mechanism. One signaling pathway is activated by Shh binding to Patched (Ptc-1) which releases inhibition of the GPCR Smoothened, activating the Shh signaling pathway and allowing progression through the G1 phase of the cell cycle. Shh can also affect progression through the G2/M transition. Patched binds to phosphorylated Cyclin B1, one component of the M-phase promoting factor (MPF), along with the kinase Cdc2. The interaction of Cyclin B1 with Patched blocks MPF activity, blocking progression through the G2/M transition. Shh binding leads to degradation of Ptc-1, release of Cyclin B1, and entry of the cyclin B1 into the nucleus. Patched acts as a tumor suppressor by blocking MPF activity. Blockade of the Hedgehog pathway by cyclopamine demonstrated the therapeutic potential of Hedgehog inhibition in the treatment of some cancers. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014724
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle
Tree Number: T4.8.9.17
database_cross_reference: NCI:C39203
database_cross_reference: NCI_BioC:C39203

PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
definition: PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of phosphatidylinositol 3-kinase. Many of the cancer-related mutations have been mapped to the phosphatase catalytic domain; it has been suggested that the phosphatase activity of PTEN is required for its tumor suppressor function. The activation of PKB/AKT is regulated in a complex manner via phosphorylation of AKT on Thr308 and Ser473 by PDK1 and ILK (integrin-linked kinase) respectively. Inactivation of PTEN will constitutively activate PKB/AKT pathway. In addition to its role in regulating the PI 3-K/AKT cell survival pathway, PTEN also inhibits growth factor-induced Shc phosphorylation and suppresses the mitogen-activated protein (MAP) kinase signaling pathway. PTEN also interacts with FAK, a key molecule implicated in integrin signaling pathways, and it directly dephosphorylates tyrosine-phosphorylated FAK. PTEN down-regulation of p130CAS through FAK results in inhibition of cell migration and spreading. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014725
Subclass_of: Cell Cycle Regulation Pathway
Synonym: PTEN dependent cell cycle arrest and apoptosis
Tree Number: T4.8.9.18
database_cross_reference: NCI:C39205
database_cross_reference: NCI_BioC:C39205

Regulation of Retinoblastoma Protein Pathway
type: Class
subclass of: Cell Cycle Regulation Pathway
PMOID: PMO:00014726
Subclass_of: Cell Cycle Regulation Pathway
Synonym: Regulation of retinoblastoma protein
Tree Number: T4.8.9.19
database_cross_reference: NCI:C91663
database_cross_reference: NCI_PID:C91663

Centrosome Pathway
type: Class
subclass of: Regulatory Pathway
definition: Protein kinase A regulatory subunit RII-alpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-kinase anchoring protein AKAP350 (also known as AKAP450 and CGNAP), MAP2 and Pericentrin. This diagram illustrates these three PKA-RII binding complexes. The cyclin B-p34(cdc2) kinase (CDK1) has been shown to phosphorylate PKA-RIIa on T54 and this has been proposed to alter the subcellular localization of PKA-RIIa at the onset of mitosis. It has been demonstrated that PKA-RIIa dissociates and redistributes from centrosomes at mitosis. The focal point of this illustration is the AKAP350 complex. In addition to binding PKA-RIIa, AKAP350 binds PKN (Takahashi et al 1999) and the phosphatases PP1 and PPA2 (Takahashi et al 1999). PKN is a serine/threonine protein kinase, having a catalytic domain homologous to the PKC family in the C-terminal region and a unique regulatory region in the N-terminal region. PKN is activated by a small GTPase RhoA and unsaturated fatty acids such as arachidonic acid. The binding of both kinases and phosphatases by the same scaffold protein provides a focal point where physiological events, such as cell cycle progression and intracellular membrane traffic, may be regulated by phosphorylation state of specific protein substrates. There are at least 4 isoforms of AKAP350 which lead to the possibility that they may behave differently at different subcellular locations. MAP2 is a member of a group of proteins that provide microtubule stabilization. MAP2 affinity appears to be dependent on PKA phosphorylation of MAP2. Pericentrin is also an AKAP (Diviani and Scott). Pericentrin binds Dynein which is also regulated by PKA leading to the possibility that pericentrin positions PKA to regulate dynein function (Diviani and Scott). (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014727
Subclass_of: Regulatory Pathway
Synonym: Protein Kinase A at the Centrosome
Tree Number: T4.8.10
database_cross_reference: NCI:C38980
database_cross_reference: NCI_BioC:C38980

CFTR Pathway
type: Class
subclass of: Regulatory Pathway
definition: The defects in cAMP-regulated chloride channel CTFR are believed to be the major cause for cystic fibrosis. Regulation of CFTR protein by the surface receptor beta adrenergic receptor is mediated through the ezrin/radixin/moesin binding phosphoprotein 50 (EBP50), which binds both the C-termini CFTR and b2AR through their PDZ binding motifs. In the resting state, CFTR, b2AR, and EBP50 exist as a macromolecular complex on the apical surface of epithelial cells. Upon agonist activation of the b2AR, the adenylate cyclase is stimulated through the G protein pathway, leading to an increase in cAMP. The elevated concentration of cAMP activates PKA, which is anchored near CFTR via interaction with Ezrin. The phosphorylation of CFTR by PKA disrupts the complex and leads to compartmentalized and specific signaling of the channel. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014728
Subclass_of: Regulatory Pathway
Synonym: Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway
Tree Number: T4.8.11
database_cross_reference: NCI:C39027
database_cross_reference: NCI_BioC:C39027

ChREBP Pathway
type: Class
subclass of: Regulatory Pathway
definition: Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through transcriptional regulation by the glucose responsive transcription factor ChREBP. ChREBP, carbohydrate responsive element binding protein, is a transcription factor that is activated by high levels of carbohydrates and repressed by cAMP. The activation of ChREBP by elevated carbohydrate levels increases the activity of genes involved in glucose metabolism such as pyruvate kinase, a rate-limiting enzyme in glycolysis, increasing the overall rate of utilization of carbohydrates. Excess carbohydrates also increase the transcription of genes that convert carbohydrates to triglycerides in the liver for storage in adipose tissue. cAMP regulates ChREBP activity by activating PKA, which phosphorylates ChREBP. Phosphorylation of ChREBP at ser(196) inactivates nuclear import and phosphorylation at Thr(666) prevents DNA binding by ChREBP. A metabolite of glucose activates protein phosphatase PP2A that then dephosphorylates both sites on ChREBP in response to increased glucose levels and increases ChREBP activity. Other pathways also regulate ChREBP activity and response to nutrients. High fat diets repress ChREBP activation by increasing AMP in liver cells, activating the AMP kinase. Phosphorylation of ChREBP by AMP kinase inactivates ChREBP and blocks glucose induction of ChREBP, linking dietary fatty acids to the regulation of carbohydrate metabolism. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014729
Subclass_of: Regulatory Pathway
Synonym: ChREBP regulation by carbohydrates and cAMP
Tree Number: T4.8.12
database_cross_reference: NCI:C39029
database_cross_reference: NCI_BioC:C39029

Chromatin Remodeling Complex and Coactivator Pathway
type: Class
subclass of: Regulatory Pathway
definition: RXR and RAR are nuclear receptors that bind either all trans retinoic (tRA) or 9cis retinoic acid (9cisRA). In the absence of ligand corepressors with histone deacetylase activity are bound to the RAR/RXR heterodimer and suppress transcription. Once they bind retinoic acid a conformational change in the receptors cause the dissociation of the corepressors and the binding of coactivators with histone acetylase activity. Following ligand binding by the heterodimer the receptors and proteins in the basal transcription machinery (like TBP and TAF135) are degraded by the proteasome. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014730
Subclass_of: Regulatory Pathway
Synonym: Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
Tree Number: T4.8.13
database_cross_reference: NCI:C39216
database_cross_reference: NCI_BioC:C39216

CK1/CDK5 Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Cdk5 is a cyclin dependent protein kinase involved in dopaminergic signaling in the neostriatal region of the brain. The role of cdk5 in dopamine responses occurs through phosphorylation of DARPP-32. Casein kinase 1 (CK1) also regulates DARPP-32 phosphorylation and dopamine signaling. The phosphorylation of DARPP-32 by cdk5 reduced dopamine signaling. Depending on its phosphorylation state, DARPP-32 inhibits either protein phosphatase 1 (PP1) or PKA. The role of mGLUR1 in this process is supported by the induction of cdk5 and CK1 activity by the mGLUR1 agonist DHPG and the subsequent phosphorylation of DARPP-32 associated with DHPG treatment of nigrostriatal neurons. CK-1 and Ckd5 inhibitors block the DHPG induced DARPP-32 phosphorylation. Dopamine exerts a positive signal that increases dopamine response by reversing phosphorylation of DARPP-32 at threonine-75. Dopamine initiates this pathway through activation of the D1 dopamine receptor, a Gs coupled GPCR, elevating cAMP and activating PKA. PKA activates protein phosphatase 2A (PP2A) which dephosphorylates DARPP-32 and increases dopamine responsiveness. This also removes the inhibition of PKA by DARPP-32, forming a positive feedback loop for further DARPP-32 inactivation by PKA. Activation of the D2 dopamine receptor has the opposite effect, shifting the DARPP-32 population toward the threonine-75 phosphorylated form. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014731
Subclass_of: Regulatory Pathway
Synonym: Regulation of ck1/cdk5 by type 1 glutamate receptors
Tree Number: T4.8.14
database_cross_reference: NCI:C39031
database_cross_reference: NCI_BioC:C39031

CTCF Pathway
type: Class
subclass of: Regulatory Pathway
definition: CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF. Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic inactivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptional activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is a multivalent DNA-sequence binder whose specificity is mediated by different sets of zinc finger (ZF) proteins. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014732
Subclass_of: Regulatory Pathway
Synonym: CTCF: First Multivalent Nuclear Factor
Tree Number: T4.8.15
database_cross_reference: NCI:C39040
database_cross_reference: NCI_BioC:C39040

DBPB Transcriptional Activation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Endothelial cells respond to treatment with the protease thrombin with increased secretion of the PDGF B-chain. This activation occurs at the transcriptional level and a thrombin response element was identified in the promoter of the PDGF B-chain gene. A transcription factor called the DNA-binding protein B (dbpB) mediates the activation of PDGF B-chain transcription in response to thrombin treatment. DbpB is a member of the Y box family of transcription factors and binds to both RNA and DNA. In the absence of thrombin, endothelial cells contain a 50 kD form of dbpB that binds RNA in the cytoplasm and may play a role as a chaperone for mRNA. The 50 kD version of dbpB also binds DNA to regulate genes containing Y box elements in their promoters. Thrombin activation results in the cleavage of dbpB to a 30 kD form. The proteolytic cleavage releases dbpB from RNA in the nucleus, allowing it to enter the nucleus and binds to a regulatory element distinct from the site recognized by the full length 50 kD dbpB. The genes activated by cleaved dbpB include the PDGF B chain. Dephosphorylation of dbpB also regulates nuclear entry and transcriptional activation. RNA digestion in vitro can release dbpB in its active form, suggesting that the protease responsible for dbpB may be closely associated in a complex. Identification of the protease that cleaves dbpB, the mechanisms of phosphorylation and dephosphorylation, and elucidation of the signaling path by which thrombin induces dbpB will provide greater understanding of this novel signaling pathway. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014733
Subclass_of: Regulatory Pathway
Synonym: Transcriptional activation of dbpb from mRNA
Tree Number: T4.8.16
database_cross_reference: NCI:C39046
database_cross_reference: NCI_BioC:C39046

EGF Receptor Downregulation by CBL Pathway
type: Class
subclass of: Regulatory Pathway
definition: As with many cell-surface receptors, activation of the EGF receptor can result in receptor internalization through receptor-mediated endocytosis, desensitizing further receptor signaling. This process requires clathrin and occurs in clathrin-coated pits, which pinch off from the plasma membrane to form vesicles that move to the early endosome. From the early endosome, receptors can either be recycled back to the cell surface, or they can move through the late endosome to the lysosome for proteolytic degradation. The sorting of receptors in the early endosome for degradation requires the tyrosine kinase activity of activated growth factor receptor and involves ubiquitination of the receptor. Targeting of receptors for degradation requires members of the Cbl gene family. Cbl proteins bind to tyrosine phosphorylated EGF receptor, and are E3 ubiquitination ligases that label receptor for degradation. Cbl also recruits Cin85 to the receptor complex, and blocking Cin85 interaction blocks receptor internalization and degradation. Endophilins are also a member of this receptor-bound protein complex. In its role as a ubiquitin ligase and docking protein, Cbl desensitizes EGF signaling and also opposes cellular proliferation induced by EGF. EGF activation also appears to activate the tyrosine kinase Src, which phosphorylates Cbl, and helps to activate the ubiquitination and degradation of EGF receptor. PKC activation and threonine phosphorylation of the EGF receptor can induce heterologous receptor internalization, but opposes Cbl-mediated receptor degradation. PKC phosphorylated receptors are sorted for recycling to the cell surface, and directed away from the late endosome and proteasome. Other growth factor receptors are regulated in a similar manner, including the PDGF receptor, HGF receptor and the CSF-1 receptor, indicating that this is a fairly general regulatory mechanism. The importance of Cbl in the down-regulation of growth factor signaling means that it will have …
PMOID: PMO:00014734
Subclass_of: Regulatory Pathway
Synonym: CBL mediated ligand-induced downregulation of EGF receptors
Tree Number: T4.8.17
database_cross_reference: NCI:C39016
database_cross_reference: NCI_BioC:C39016

eIF2 Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi and transfers the Met-tRNA to the 40S subunit, to form the 43S preinitiation complex. Later in the cycle, prior to elongation, the bound GTP is hydrolyzed, releasing eIF-2-GDP. For eIF-2 to promote another round of initiation, GDP must be exchanged for GTP, a reaction catalyzed by eIF-2B. Kinases activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), and hemin deficiency (HRI) can phosphorylate the a subunit of eIF-2. This phosphorylation stabilizes the eIF-2-GDP-eIF-2B complex, inhibiting the turnover of eIF-2B. eIF-2B is also inhibited by GSK-3b phosphorylation. These events result in a shut-down of cellular protein synthesis and can lead to apoptosis. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014735
Subclass_of: Regulatory Pathway
Synonym: Regulation of eIF2
Tree Number: T4.8.18
database_cross_reference: NCI:C39061
database_cross_reference: NCI_BioC:C39061

eIF4 Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: eIF-4F and p70 S6 kinase play critical roles in translational regulation. eIF-4F is a complex whose functions include the recognition of the mRNA 5' cap structure (eIF-4E), delivery of an RNA helicase to the 5' region (eIF-4A), bridging of the mRNA and the ribosome (eIF-4G), and circularization of the mRNA via interaction between eIF-4G and the poly(A) binding protein (PABP). Several stimuli, including growth factors and cytokines, regulate the eIF-4 complex and p70 S6 kinase by initiating a phosphorylation cascade involving the sequential activation of PI3-K, PDK1/2, Akt/PKB, and FRAP/mTOR kinase. FRAP/mTOR, together with an unidentified kinase, phosphorylates 4E-BP, leading to its dissociation from and activation of eIF-4E. MNK1/2, activated by ERK and p38 MAPK, phosphorylates and activates eIF-4E. Both processes contribute to the association of eIF-4E and eIF-4G to form the active eIF-4F complex, a necessary component of the 48S initiation complex. Phosphorylation of ribosomal protein S6 by p70 S6 kinase stimulates the translation of mRNAs with a 5' oligopyrimidine tract which typically encode components of the protein synthesis. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014736
Subclass_of: Regulatory Pathway
Synonym: Regulation of eIF4e and p70 S6 Kinase
Synonym: Regulation of eif-4e and p70s6 Kinase
Tree Number: T4.8.19
database_cross_reference: NCI:C39062
database_cross_reference: NCI_BioC:C39062

Estrogen Receptor Regulation by CARM1 Pathway
type: Class
subclass of: Regulatory Pathway
definition: Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. The methylation activity of CARM1 modulates the activity of specific transcriptional regulators. CARM1 acts as a coactivator for the myogenic transcription factor Mef2c, and is necessary for normal muscle cell differentiation. The estrogen receptor is another transcription factor that uses CARM1 as one of several coactivators, acting synergistically with CBP through the Grip1 member of the p160 family of coactivators. The interaction of estrogen receptor with various ligand-dependent coactivators may produce the tissue selective response of some estrogen receptor ligands like tamoxifen. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014737
Subclass_of: Regulatory Pathway
Synonym: CARM1 and Regulation of the Estrogen Receptor
Tree Number: T4.8.20
database_cross_reference: NCI:C39013
database_cross_reference: NCI_BioC:C39013

FOXA Transcription Factor Signaling Pathway
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014738
Subclass_of: Regulatory Pathway
Synonym: FOXA transcription factor networks
Tree Number: T4.8.21
database_cross_reference: NCI:C91597
database_cross_reference: NCI_PID:C91597

FOXA1 Transcription Factor Signaling Pathway
type: Class
subclass of: FOXA Transcription Factor Signaling Pathway
PMOID: PMO:00014739
Subclass_of: FOXA Transcription Factor Signaling Pathway
Synonym: FOXA1 transcription factor network
Tree Number: T4.8.21.1
database_cross_reference: NCI:C91598
database_cross_reference: NCI_PID:C91598

FOXA2 and FOXA3 Transcription Factor Signaling Pathway
type: Class
subclass of: FOXA Transcription Factor Signaling Pathway
PMOID: PMO:00014740
Subclass_of: FOXA Transcription Factor Signaling Pathway
Synonym: FOXA2 and FOXA3 transcription factor networks
Tree Number: T4.8.21.2
database_cross_reference: NCI:C91599
database_cross_reference: NCI_PID:C91599

FOXM1 Transcription Factor Signaling Pathway
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014741
Subclass_of: Regulatory Pathway
Synonym: FOXM1 transcription factor network
Tree Number: T4.8.22
database_cross_reference: NCI:C91600
database_cross_reference: NCI_PID:C91600

FOXO Transcription Factor Family Signaling Pathway
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014742
Subclass_of: Regulatory Pathway
Synonym: FoxO family signaling
Tree Number: T4.8.23
database_cross_reference: NCI:C91601
database_cross_reference: NCI_PID:C91601

Gap Junction Assembly Pathway
type: Class
subclass of: Regulatory Pathway
definition: Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
PMOID: PMO:00014743
Subclass_of: Regulatory Pathway
Synonym: Gap junction
Tree Number: T4.8.24
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91478
database_cross_reference: NCI_KEGG:C91478

Gene Expression Regulation by Vitamin D Receptor Pathway
type: Class
subclass of: Regulatory Pathway
definition: A pathway that modulates the expression of genes involved in calcium homeostasis, bone formation, cellular differentiation, cell growth and apoptosis through the direct interaction between the nuclear receptor, vitamin D3 receptor (VDR), primarily as part of a heterodimeric complex with the retinoid X receptor (RXR), and vitamin D response elements (VDREs) found in the promoter regions of vitamin D regulated genes.
PMOID: PMO:00014744
Subclass_of: Regulatory Pathway
Synonym: Control of Gene Expression by Vitamin D Receptor
Tree Number: T4.8.25
database_cross_reference: NCI:C39263
database_cross_reference: NCI_BioC:C39263

Homeostasis Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: An elaboration of the biological or biochemical events that are involved in the maintenance of the internal physiology of an organism.
PMOID: PMO:00014745
Subclass_of: Regulatory Pathway
Tree Number: T4.8.26
database_cross_reference: NCI:C91822

Aldosterone-Regulated Sodium Reabsorption Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-term blood pressure. Aldosterone plays a major role in sodium and potassium metabolism by binding to epithelial mineralocorticoid receptors (MR) in the renal collecting duct cells localized in the distal nephron, promoting sodium resorption and potassium excretion. Aldosterone enters a target cell and binds MR, which translocates into the nucleus and regulates gene transcription. Activation of MR leads to increased expression of Sgk-1, which phosphorylates Nedd4-2, an ubiquitin-ligase which targets ENAC to proteasomal degradation. Phosphorylated Nedd4-2 dissociates from ENAC, increasing its apical membrane abundance. Activation of MR also leads to increased expression of Na+/K+-ATPase, thus causing a net increase in sodium uptake from the renal filtrate. The specificity of MR for aldosterone is provided by 11beta-HSD2 by the rapid conversion of cortisol to cortisone in renal cortical collecting duct cells. Recently, besides genomic effects mediated by activated MR, rapid aldosterone actions that are independent of translation and transcription have been documented.
PMOID: PMO:00014746
Subclass_of: Homeostasis Regulation Pathway
Synonym: Aldosterone-regulated sodium reabsorption
Tree Number: T4.8.26.1
database_cross_reference: NCI:C91503
database_cross_reference: NCI_KEGG:C91503

Angiotensin-converting Enzyme 2 Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Cardiovascular diseases are predicted to be the most common cause of death worldwide by 2020. The major regulator of blood pressure homeostasis is the renin-angiotensin system. Angiotensinogen is digested by renin to produce angiotensin I (AGT I). AGT I is an inactive 10 amino-acid peptide that is further degraded to produce angiotensin II by the angiotensin-converting enzyme (ACE). Angiotensin II is the master regulator of blood pressure increase acting on the heart, kidneys and blood vessels. Angiotensin II causes direct constriction of the resistance vessels and stimulation of the adrenal thereby increasing blood volume and sodium absorption. In 2000, Tipnis et al. discovered ACE 2 a second carboxypeptidase that digests angiotensin. ACE is a di-peptidase, cleaving off 2 peptides from the c-terminal end of angiotensin. ACE 2 only cleaves 1 amino acid to produce angiotensin 1-9 (AGT 1-9) which has no identified function at this time. AGT 1-9 is not converted to angiotensin II but further degraded by ACE to AGT 1-7, a vasodilator. It would appear that ACE 2 inhibits the formation of angiotensin and reduces blood pressure increases. Crackower et al determined that ace2 -/- mice suffered significant heart defects at 6 months. Further deletion of ACE resulted in restored cardiac functions. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014747
Subclass_of: Homeostasis Regulation Pathway
Synonym: Angiotensin-converting enzyme 2 regulates heart function
Tree Number: T4.8.26.2
database_cross_reference: NCI:C38969
database_cross_reference: NCI_BioC:C38969

Bone Mineralization Regulation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs) and by propagating the crystals onto the collagenous extracellular matrix. Two osteoblast proteins, tissue-nonspecific alkaline phosphatase (TNAP) and plasma cell membrane glycoprotein-1 (PC-1) are involved in this process. In the bone matrix, PC-1 is the major producer of PPi, which in turn has an inhibitory effect on hydroxyapatite deposition. TNAP has a positive influence on mineralization primarily by controlling the size of the inhibitory pool of PPi through its inorganic pyrophosphatase activity. TNAP also generates Pi by using NTPs and PPi as substrates, but other more major sources of Pi e.g., intestinal absorption, are likely to contribute the bulk of the Pi needed for hydroxyapatite deposition. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014748
Subclass_of: Homeostasis Regulation Pathway
Synonym: Regulators of Bone Mineralization
Tree Number: T4.8.26.3
database_cross_reference: NCI:C39172
database_cross_reference: NCI_BioC:C39172

Cardiac Muscle Contraction Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
PMOID: PMO:00014749
Subclass_of: Homeostasis Regulation Pathway
Synonym: Cardiac muscle contraction
Tree Number: T4.8.26.4
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91467
database_cross_reference: NCI_KEGG:C91467

Circadian Rhythm Pathway BioCarta
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Organisms from flies to humans have daily circadian rhythms entrained with the 24-hour cycle of day and night that regulate many physiological systems. In mammals, there appears to be a master regulator of circadian rhythms in the hypothalamus, as well as additional peripheral mechanisms. The basic framework of the molecular pathways in the cell that produce and maintain these daily rhythms has been elucidated. The central feature of the circadian pathways are two transcription factors, Bmal1 and Clock, that are expressed in a 24 hour cycle and that act together as a heterodimer to regulate the expression of other genes involved in maintaining the circadian rhythm. Bmal1 and Clock activate transcription of multiple Period (per) and Cryptochrome (Cry) genes. When the activity of Bmal1 and Clock is maximal, Per and Cry genes are transcribed, and then translated in the cytoplasm. The translated Per and Cry genes form a complex in the cytoplasm that is transported back into the nucleus. In the nucleus, Per and Cry form a feedback loop that inhibits transcriptional activation by Bmal1 and Clock, lowering their own expression in the process. At the same time, Per and Cry increase transcription of Bmal1 and Clock genes, to initiate the next phase of the cycle once again. This cycle runs autonomously in the cell, causing jet lag during travel, but can be regulated to retrain to changes in the light cycle. Factors that regulate the cycle include casein kinase 1 epsilon (CK1e) that phosphorylates Per2 and induces its degradation. Mutation of PER2 in humans has been genetically linked to changes in human sleep patterns. Further exploration of the factors that regulate circadian rhythms may enable manipulation of the system in sleep disorders. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014750
Subclass_of: Homeostasis Regulation Pathway
Synonym: Circadian Rhythm Pathway 2
Synonym: Circadian Rhythms
Tree Number: T4.8.26.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39030
database_cross_reference: NCI_BioC:C39030

Circadian Rhythm Pathway KEGG
type: Class
subclass of: Homeostasis Regulation Pathway
PMOID: PMO:00014751
Subclass_of: Homeostasis Regulation Pathway
Synonym: Circadian Rhythm
Tree Number: T4.8.26.6
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38796
database_cross_reference: NCI_KEGG:C38796

Circadian Rhythm Pathway PID
type: Class
subclass of: Homeostasis Regulation Pathway
PMOID: PMO:00014752
Subclass_of: Homeostasis Regulation Pathway
Synonym: Circadian rhythm pathway
Tree Number: T4.8.26.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91564
database_cross_reference: NCI_PID:C91564

Collecting Duct Acid Secretion Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: One of the important roles of the collecting duct segment of the kidney nephron is acid secretion. As daily food intake loads acid into the body, urinary acid excretion is essential, and urine pH can drop as low as 4.5. The alpha-intercalated cell of collecting duct is the main responsible for hydrogen secretion into the urine. The carbon dioxide, which is generated in the cells and enters from the blood, is changed to carbonic acid. This carbonic acid is divided into hydrogen ion and bicarbonate ion. Intracellular CA II catalyses the formation of these ions. The hydrogen ion is secreted into the lumen by the luminal H(+)-ATPase. The bicarbonate ion is transported to the blood side by the anion exchanger type 1. Hydrogen ion in the lumen is trapped by urinary buffers. These include ammonium and phosphate.
PMOID: PMO:00014753
Subclass_of: Homeostasis Regulation Pathway
Synonym: Collecting duct acid secretion
Tree Number: T4.8.26.8
database_cross_reference: NCI:C91493
database_cross_reference: NCI_KEGG:C91493

Fibrinolysis Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Clot formation and fibrinolysis is a balance of plasmin activation/inhibition and thrombin-thrombomodulin activity that regulates fibrin polymer formation and degradation. Active thrombin is produced by the cleavage of prothrombin in the intrinsic thrombin activation pathway or the extrinsic thrombin activation pathway. Cleavage of fibrinogen by thrombin releases the fibrin monomers that auto-polymerize within seconds into fibrin threads or fibers. The coagulation cascade has many feedback loops. One example is the binding of thrombin to the fibrin polymers resulting in a reduction in soluble thrombin. The fibers form a more stable clot as a result of the covalent bonds formed by activated factor XIII enzyme (also known as Fibrin-stabilizing factor). These fibers form a mesh that traps platelets, blood cells and plasma to form a clot. The removal of the clot is caused by plasmin cleavage of the fibrin monomers into soluble fibrin degradation products. Plasmin is formed by the cleavage of plasminogen between Arg561 and Val562. Plasmin is a two-chain trypsin-like serine protease. Plasminogen activator inhibitor 1 (PAI1) and plasminogen activator inhibitor 2 (PAI2) inhibit cleavage of plasminogen by tissue-type plasminogen activator (tPA) or urokinase plasminogen activator (uPA). The presence of fibrin fibers and fibrin degradation products [(DD)E1 and (DD)E2] exert a two-fold stimulation of tPA and uPA. Plasmin activity is also inhibited by alpha2-antiplasmin. Thrombin activatable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like proenzyme activated by the thrombin-thrombomodulin dimer. TAFI cleaves (DD)E2 to separate DD and E fragments which do not enhance the activation of tPA or uPA and results in a reduced feedback signal. Overabundance or increased activity of the plasminogen activator inhibitors or reduced presence or function of tPA or uPA can result in atherosclerotic disease and venous thrombosis due to an increase in fibrin deposition or formation o…
PMOID: PMO:00014754
Subclass_of: Homeostasis Regulation Pathway
Tree Number: T4.8.26.9
database_cross_reference: NCI:C39080
database_cross_reference: NCI_BioC:C39080

Food Intake and Energy Homeostasis Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: The synthesis and release of growth hormone (GH) from the pituitary are controlled by the hypothalamic hormones GH-releasing hormone (GHRH) and somatostatin (SRIF), which in turn are regulated by feedback from blood GH and insulin-like growth factor-I (IGF-I) concentrations. The recently discovered endogenous GH-releasing peptide, called ghrelin, also stimulates GH release. Circulating GH acts directly on many organs to stimulate IGF-I production, with IGF-I production in the liver providing the main source of blood IGF-I. Most of the IGF-I in the circulation is bound to IGF-binding protein-3 (IGFBP-3) in a ternary complex with acid-labile subunit (ALS); a smaller fraction is bound to the five other IGFBP. A small fraction of the total IGF-I in blood is in a bioactive-free fraction. In the kidney, IGF-I increases renal plasma flow and GFR, whereas on bone it acts on the epiphysial plate, which leads to longitudinal bone growth. GH also has direct effects on many organs, including kidney and cartilage, which can be independent of IGF-I action. The GH/IGF-I axis in chronic renal failure (CRF) is changed markedly compared with the normal axis. In CRF, the total concentrations of the hormones in the GH/IGF-I axis are not reduced, but there is reduced effectiveness of endogenous GH and IGF-I, which probably plays a major role in reducing linear bone growth. The reduced effectiveness of endogenous IGF-I likely is due to decreased levels of free, bioactive IGF-I as levels of circulating inhibitory IGFBP are increased. In addition, less IGF-I is circulating in the complex with ALS and IGFBP-3 as a result of increased proteolysis of IGFBP-3. Together, these lead to decreased IGF-I receptor activation and a decreased feedback to the hypothalamus and pituitary. Low free IGF-I and high IGFBP-1 and -2 levels probably contribute to a reduced renal function and lead to a reduced stature. The direct effects of GH on bone, which are poorly understood, also are blunted. (This definit…
PMOID: PMO:00014755
Subclass_of: Homeostasis Regulation Pathway
Synonym: Ghrelin: Regulation of Food Intake and Energy Homeostasis
Tree Number: T4.8.26.10
database_cross_reference: NCI:C39093
database_cross_reference: NCI_BioC:C39093

Gastric Acid Secretion Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetylcholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+, K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and H+ secretion into the stomach lumen.
PMOID: PMO:00014756
Subclass_of: Homeostasis Regulation Pathway
Synonym: Gastric acid secretion
Tree Number: T4.8.26.11
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91811
database_cross_reference: NCI_KEGG:C91811

Hemoglobin Chaperone Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: The function of hemoglobin in oxygen transport by red blood cells requires precise assembly of a tetramer of two beta-subunits and two alpha-units. If too many beta-subunits are present, then all tetramers of beta-subunits are formed that bind oxygen but do not release it when needed. When alpha-subunits are in excess they form precipitates with oxidized heme that damage red blood cells. Red blood cells require a precise coregulation of alpha and beta subunit expression to maintain the proper ratio of the subunits and normal red blood cell function. Generally red blood cells express slightly more alpha than beta-subunits to avoid forming unproductive beta-tetramers (HbH). The slight excess of alpha units are blocked from precipitation by a molecular chaperone, AHSP, alpha-hemoglobin stabilizing protein. Expression of the AHSP gene is coordinately activated with the globin genes and heme biosynthesis genes by the GATA-1 gene involved in erythrocyte differentiation. AHSP blocks precipitation of alpha-units, and promotes the formation of normal productive alpha-beta tetramers (HbA). People with mutation or deletion of the beta-subunit gene have Beta-thalassemias resulting from an over-abundance of alpha subunits and their precipitation. The severity of the phenotype may depend on the AHSP genotype of these individuals and elevating AHSP levels through gene therapy may provide a treatment strategy for beta-thalassemia. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014757
Subclass_of: Homeostasis Regulation Pathway
Synonym: Hemoglobin's Chaperone
Tree Number: T4.8.26.12
database_cross_reference: NCI:C38976
database_cross_reference: NCI_BioC:C38976

HSP27 Regulation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through necrotic or apoptotic cell death, while increased expression and phosphorylation of heat shock proteins such as Hsp27 can protect cells against cellular stress. Heat shock proteins commonly exhibit molecular chaperone activity and also interact with a wide variety of proteins to exert specific effects. The small heat shock protein Hsp27 exists as monomers, dimers, and oligomers in the cell, and each form has distinct activities. Oligomers are the main form of Hsp27 with molecular chaperone activity and are disrupted by phosphorylation of Hsp27 to form dimers and monomers. S-thiolation of Hsp27 on cysteine also dissociates oligomers and may provide another route of regulating the action of Hsp27 in stress. Map kinase cascades mediate Hsp27 phosphorylation. Heat stress activates the p38 kinase cascade and induces phosphorylation of Hsp27 by the downstream Map kinases Mapkapk2 and Mapkap3. Cytokines such as TNF and IL-1 can also induce Hsp27 phosphorylation through this Map kinase cascade, protecting cells in some settings against cytotoxic responses. In stressful conditions, dissociation of oligomeric Hsp27 by phosphorylation may allow lower molecular weight forms to perform other non-chaperone functions. One action of Hsp27 induced by stress is to protect cells against apoptosis and a common component of apoptotic pathways is the mitochondrial release of cytochrome c. One way that Hsp27 reduces apoptosis is by preventing the release of cytochrome c and by binding to cytochrome c in the cytosol. Downstream, Hsp27 also blocks caspase 9 activation and the subsequent activation of caspase 3, inhibiting the rest of the proteolytic caspase cascade. Yet a further role of Hsp27 in blocking apoptosis is through blocking Fas-induced apoptosis. Fas is a receptor in the TNF receptor gene family that induces apoptosis when stimulated b…
PMOID: PMO:00014758
Subclass_of: Homeostasis Regulation Pathway
Synonym: Stress Induction of HSP Regulation
Tree Number: T4.8.26.13
database_cross_reference: NCI:C39108
database_cross_reference: NCI_BioC:C39108

Hypoxia-Inducible Factor Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Hypoxia (or low O2 levels) affects various pathologies. First, tissue ischemia, a variation in O2 tension caused by hypoxia/reoxygenation, can lead to endothelial cell changes. For example, long periods of ischemia result in endothelial changes, such as vascular leakage, resulting in varicose veins. In more severe situations, ischemia can lead to myocardial or cerebral infarction and retinal vessel occlusion. Of interest, HIF-1 is stabilized prior to induction of vascular endothelial growth factor (VEGF) expression during acute ischemia in the human heart. Second, pulmonary hypertension associated with chronic respiratory disorders results from persistent vasoconstriction and vascular remodeling. Third, hypoxic gradients created in enlarging solid tumors trigger expression of genes containing hypoxia response elements (HREs) such as those involved in angiogenesis. This allows subsequent delivery of O2, nutrients, and further tumor growth. Vascular remodeling is an important component to tumorigenesis; without proper blood supply, delivery of oxygen may occur by diffusion, but becomes inefficient in tumors greater than 1 mm in diameter. Short-term hypoxia can also elevate platelet numbers, while prolonged exposure may cause some degree of thrombocytopenia in response to increased levels of erythropoietin (EPO). Another disorder involving inadequate responses to hypoxia is preeclampsia, a pathology of pregnancy thought to be caused by improper differentiation of placental trophoblast cells due to poorly controlled O2 tension or improper hypoxia-inducible factor (HIF)-mediated responses. The primary molecular mechanism of gene activation during hypoxia is through HIF-1. Several genes involved in cellular differentiation are directly or indirectly regulated by hypoxia. These include EPO, LDH-A, ET-1, transferrin, transferrin receptor, VEGF, Flk-1, Flt-1, platelet-derived growth factor-beta (PDGF-b), basic fibroblast growth factor (bFGF), and others genes affecting glyco…
PMOID: PMO:00014759
Subclass_of: Homeostasis Regulation Pathway
Synonym: Hypoxia-Inducible Factor in the Cardiovascular System
Tree Number: T4.8.26.14
database_cross_reference: NCI:C39105
database_cross_reference: NCI_BioC:C39105

Ion Channels in Vascular Endothelium Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Endothelial cells (EC) form a multifunctional signal-transducing surface that performs different tasks dependent on its localization in the vessel tree. Arterial EC provide a pathway for delivery of oxygen from blood to tissue. They modulate the tone of vascular smooth muscle cells, which in turn controls blood pressure and blood flow by adjusting the caliber of arteries and arterioles. In the microvascular bed, EC regulate the permeation of various metabolites, macromolecules, and gases, as well as autocrine and paracrine factors and are involved in the regulation of cell nutrition. In all vessel types, EC are involved in blood coagulation, control of the transport between blood and tissue, movement of cells adhering to EC, wound healing, and angiogenesis. Other functions require an active response of EC to various signals of mechanical, chemical, or neuronal nature. This signal transduction is impaired during vessel disease (arteriosclerosis) and injury, inflammation, or hemodynamic disturbances (hypertension). The role of ion channels in the transduction of these signals into cellular responses is still a matter of debate and has received substantial attention only in the last few years. Our current knowledge is limited to effects of ion channels on fast endothelial responses, these channels being mainly essential for the regulation of Ca2+ signaling. Here we illustrate the negative feedback of cyclic nucleotides (CNG)-induced membrane depolarization on Ca2+ entry. Ca2+ entry via receptor-activated cation channels (RACC) and/or store-operated or capacitative (SOC) elevates [Ca2+]i and stimulates endothelial nitric oxide synthase (eNOS). The subsequent activation of soluble guanylate cyclase (sGC) increases cGMP. cGMP and cAMP, via agonist activation of G protein-coupled receptors (GPCRs), Gs, and adenylate cyclase (AC), activate CNG and/or nonselective cation channels (HCN) channels, which induce membrane depolarization. This depolarization exerts a negative feed…
PMOID: PMO:00014760
Subclass_of: Homeostasis Regulation Pathway
Synonym: Ion Channels and Their Functional Role in Vascular Endothelium
Tree Number: T4.8.26.15
database_cross_reference: NCI:C39209
database_cross_reference: NCI_BioC:C39209

Long-Term Depression Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization.
PMOID: PMO:00014761
Subclass_of: Homeostasis Regulation Pathway
Synonym: Long-term depression
Tree Number: T4.8.26.16
database_cross_reference: NCI:C91463
database_cross_reference: NCI_KEGG:C91463

Long-Term Potentiation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII). Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
PMOID: PMO:00014762
Subclass_of: Homeostasis Regulation Pathway
Synonym: LTP Pathway
Synonym: Long-term potentiation
Tree Number: T4.8.26.17
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91482
database_cross_reference: NCI_KEGG:C91482

Longevity Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: A demonstrated means to increase lifespan in a wide range of organisms is through the restriction of caloric intake. Reducing the consumption of calories increases the lifespan of many different organisms, including mice. Caloric restriction not only increases lifespan, but decreases age-related deterioration of systems and physiological responses, reducing age related diseases like cancer and neurodegenerative disease. Although caloric restriction has not been demonstrated experimentally to increase human lifespan, short-term changes in physiological measures like insulin responsiveness have been observed. Caloric restriction in animals reduces the levels of plasma glucose and insulin and reduces inflammatory responses and may reduce oxidative stress through reduced oxidative metabolism, further contributing to the health benefits of reduced calorie intake. The reduction in inflammation may be related to reduced plasma glucose and in humans could reduce an inflammation connection to cancer, heart disease, and Alzheimer's disease. Genetic analysis has indicated several genes that influence lifespan, particularly those that alter pituitary development, reduce growth hormone secretion, reduce food intake, and reduce apoptosis (p66 Shc). All of these appear to converge on an IGF-1 receptor pathway and to reproduce many of the effects of caloric restriction. Although dwarf mice with defective growth hormone or IGF-1 signaling also have significantly increased lifespan, humans with defects in growth hormone signaling tend to develop diseases that shorten their lifespan. One of the downstream actions of IGF-1 signaling is to repress stress resistance proteins including antioxidant enzymes like superoxide dismutase and heat shock proteins, so a reduction in IGF signaling may extend lifespan by increasing the expression of stress resistance genes. The link between caloric restriction and IGF signaling may be the increased expression of stress resistance proteins. In additio…
PMOID: PMO:00014763
Subclass_of: Homeostasis Regulation Pathway
Synonym: The IGF-1 Receptor and Longevity
Tree Number: T4.8.26.18
database_cross_reference: NCI:C39141
database_cross_reference: NCI_BioC:C39141

Mucosal Healing Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Maintaining the integrity of the gastrointestinal tract despite the continual presence of microbial flora and injurious agents is essential. Epithelial repair requires restitution and regeneration. During restitution, epithelial cells spread and migrate across the basement membrane to re-establish surface-cell continuity, a process that is independent of cell proliferation. Epithelial continuity depends on a family of small abundant secreted proteins, the trefoil factors (TFFs). The trefoil factor (TFF) family comprises the gastric peptides pS2/TFF1 and spasmolytic peptide (SP)/TFF2, and the intestinal trefoil factor (ITF)/TFF3. Their fundamental action is to promote epithelial-cell restitution within the gastrointestinal tract. TFFs are abundantly secreted onto the mucosal surface by mucus-secreting cells. Their expression is rapidly and coordinately upregulated at the margins of mucosal injury. Secreted TFF acts on adjacent mucosal cell populations either extracellularly (augmenting barrier function) or intracellularly (transcriptional and signaling events). TFF response elements in TFF gene promoters allow increases in TFF expression through auto-induction and cross-induction of other TFFs, in addition to mucin expression and possibly tumor suppression. Cell migration is the result of integrated disruption of cell-cell and cell-substratum adhesion and prevention of apoptosis through cell detachment. Epithelial movement therefore requires integration of motogenic and cell-survival signals. This is achieved by activation of several intracellular signaling pathways that converge on ERK/MAPK and possibly NF-B activation. Serine phosphorylation of the extracellular signal-regulated kinases (ERKs)/mitogen-activated protein kinases (MAPKs) 1 and 2 is central to trefoil factor-mediated signaling, lying downstream of EGFR activation and possibly FAK activation (through recruitment of GRB2 and SOS). Cell migration might result from cooperation between ERK/MAPKs and Rho pro…
PMOID: PMO:00014764
Subclass_of: Homeostasis Regulation Pathway
Synonym: Trefoil Factors Initiate Mucosal Healing
Tree Number: T4.8.26.19
database_cross_reference: NCI:C39250
database_cross_reference: NCI_BioC:C39250

Myosin Phosphatase Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: The phosphorylation of myosin affects its role in smooth muscle contraction, platelet formation, and possibly other processes. Phosphorylation by myosin light chain kinase (MLCK) increases myosin activity and dephosphorylation by myosin phosphatase decreases myosin activity. CPI, a factor that binds to and inhibits myosin phosphatase, is a target of phosphorylation by PKC and PKN. The inhibitory activity of CPI is regulated by its own phosphorylation state; when CPI is phosphorylated, its inhibitory activity is increased. The activation of signal transduction cascades such as GPCR pathways can lead to activation of PKC, phosphorylation of CPI, inhibition of myosin phosphatase, increased myosin phosphorylation, and increased smooth muscle contraction or platelet release. The action of histamine in vasoconstriction, for example, may be mediated by activation of PKC through the histamine receptor, resulting in phosphorylation of CPI-17, increased inhibition of myosin phosphatase, and increased smooth muscle contraction. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014765
Subclass_of: Homeostasis Regulation Pathway
Synonym: Myosin Pathway
Synonym: PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
Tree Number: T4.8.26.20
database_cross_reference: NCI:C39160
database_cross_reference: NCI_BioC:C39160

Oxidative Stress Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Reactive oxygen species (ROS) are detrimental to cellular health and can damage biological macromolecules. Electrophilic compounds, xenobiotics and antioxidants are sources of reactive oxygen species, creating oxidative stress that can harm cells. Enzymes involved in the Phase II detoxification of xenobiotics to reduce cellular stress include glutathione transferases, quinone reductase, epoxide hydrolase, heme oxygenase, UDP-glucuronosyl transferases, and gamma-glutamylcysteine synthetase. Expression of these genes protects cells from oxidative damage and can prevent mutagenesis and cancer. Transcription of these enzymes is coordinately regulated through antioxidant response elements (AREs). Nrf2 (NF-E2-related factor 2) and Nrf1 are transcription factors that bind to AREs and activate these genes. Inactive Nrf2 is retained in the cytosol by association a complex with the cytoskeletal protein Keap1. Cytosolic Nrf2 is phosphorylated and translocates into the nucleus in response to protein kinase C activation and Map kinase pathways. In the nucleus, Nrf2 activate genes through AREs by interacting with transcription factors in the bZIP family, including CREB, ATF4 and fos or jun. Nrf2 activation of genes is opposed by small maf proteins, including MafG and MafK, maintaining a counterbalance to Nrf2 and balancing the oxidation level of the intracellular environment. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014766
Subclass_of: Homeostasis Regulation Pathway
Synonym: Oxidative Stress Induced Gene Expression Via Nrf2
Tree Number: T4.8.26.21
database_cross_reference: NCI:C38990
database_cross_reference: NCI_BioC:C38990

Platelet Aggregation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Eph kinases are a family of receptor tyrosine kinases with an extracellular domain that binds their ligand, the ephrins, and an intracellular kinase domain. The ephrins are also expressed on the cell surface, so that interaction between Eph kinases and ephrins occurs at the interface between neighboring cells. Binding of ephrins to Eph kinases stimulates signaling in both directions across the interface between cells, in both the receptor expressing and the ligand expressing cells. Eph kinases and ephrins are involved in several biological processes, and their role in neuronal development has been extensively examined. Both Eph kinases (EphA4 and EphB1) and ephrins (ephrinB1) are expressed on platelets, suggesting that activation of eph kinases by ephrins may play a role in clotting when platelets are brought into close proximity in the developing clot. Platelet activation progresses in stages with an early stage that is stimulated by soluble factors like ADP acting through GPCRs and is reversible and later stages with stronger interaction between platelets that may require interaction between Eph kinases and ephrins. One of the molecular targets of signaling by Eph kinases and ephrins is the actin cytoskeleton, which also plays a role in platelet activation. Clustering Eph kinases or ephrins in platelets stimulated cytoskeletal changes as well as other markers of platelet activation during clotting such as secretion of alpha-granules to release clotting factors. Clustering ephrins together activated Rap1b, a ras gene family member that may regulate integrins. Platelet activation caused Eph kinases to bind to src family members Fyn and Lyn and also with the cell adhesion molecule L1. Failure of the ephrins/Eph kinase pathway to function normally in platelets may result in loosely associated platelets and improper clot formation. Eph kinases and ephrins are also expressed on the vascular wall by endothelial cells, suggesting that signaling by these proteins may also …
PMOID: PMO:00014767
Subclass_of: Homeostasis Regulation Pathway
Synonym: Eph Kinases and ephrins support platelet aggregation
Tree Number: T4.8.26.22
database_cross_reference: NCI:C39065
database_cross_reference: NCI_BioC:C39065

Platelet Amyloid Precursor Protein Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: The amyloid-beta peptide (Ab), a proteolytic fragment of amyloid precursor protein (APP), is the major component of senile plaques, the hallmark of Alzheimer's disease. Platelets contain both APP and Ab and probably contribute greater than 90% of circulating APP. The soluble APP is the major inhibitor of coagulation factors IXa and XIa, and platelet aggregation. Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules. These important molecules released from platelets are key regulators of hemostasis, the physiologic arrest of hemorrhage at site of vascular leakage. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014768
Subclass_of: Homeostasis Regulation Pathway
Tree Number: T4.8.26.23
database_cross_reference: NCI:C39191
database_cross_reference: NCI_BioC:C39191

Proximal Tubule Bicarbonate Reclamation Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: One of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "new HCO3(-)" for regulating blood pH. In the tubular lumen, filtered HCO3(-) combines with H(+) in a reaction catalyzed by CA IV. The CO2 thus produced rapidly diffuses into the tubular cells and is combined with water to produce intracellular H(+) and HCO3(-), catalyzed by soluble cytoplasmic CA II. HCO3(-) is then cotransported with Na(+) into blood via the NBC-1. The intracellular H(+) produced by CA II is secreted into the tubular lumen predominantly via the NHE-3. The PT creates the "new HCO3(-)" by taking glutamine and metabolizing it to two molecules each of NH4(+) and HCO3(-). The NH4(+) is excreted into the tubular lumen, and the HCO3(-), which is "new HCO3(-)," is returned to the blood, where it replaces the HCO3(-) lost earlier in the titration of nonvolatile acids.
PMOID: PMO:00014769
Subclass_of: Homeostasis Regulation Pathway
Synonym: Proximal tubule bicarbonate reclamation
Tree Number: T4.8.26.24
database_cross_reference: NCI:C91494
database_cross_reference: NCI_KEGG:C91494

Renin-Angiotensin Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
PMOID: PMO:00014770
Subclass_of: Homeostasis Regulation Pathway
Synonym: Renin-angiotensin system
Tree Number: T4.8.26.25
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91434
database_cross_reference: NCI_KEGG:C91434

Salivary Secretion Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP.
PMOID: PMO:00014771
Subclass_of: Homeostasis Regulation Pathway
Synonym: Salivary secretion
Tree Number: T4.8.26.26
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91810
database_cross_reference: NCI_KEGG:C91810

Vascular Smooth Muscle Contraction Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
PMOID: PMO:00014772
Subclass_of: Homeostasis Regulation Pathway
Synonym: Vascular smooth muscle contraction
Synonym: vascular smooth muscle contraction
Tree Number: T4.8.26.27
database_cross_reference: GO:GO:0014829
database_cross_reference: NCI:C91523
database_cross_reference: NCI_KEGG:C91523

Vasopressin-Regulated Water Reabsorption Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again.
PMOID: PMO:00014773
Subclass_of: Homeostasis Regulation Pathway
Synonym: Vasopressin-regulated water reabsorption
Tree Number: T4.8.26.28
database_cross_reference: NCI:C91485
database_cross_reference: NCI_KEGG:C91485

Vitamin C in Brain Pathway
type: Class
subclass of: Homeostasis Regulation Pathway
definition: Vitamin C (ascorbic acid) was first identified by virtue of the essential role it plays in collagen modification, preventing the nutritional deficiency scurvy. Vitamin C acts as a cofactor for hydroxylase enzymes that post-translationally modify collagen to increase the strength and elasticity of tissues. Vitamin C reduces the metal ion prosthetic groups of many enzymes, maintaining activity of enzymes, and also acts as an anti-oxidant. Although the prevention of scurvy through modification of collagen may be the most obvious role for vitamin C, it is not necessarily the only role of vitamin C. Svct1 and Svct2 are ascorbate transporters for vitamin C import into tissues and into cells. Both of these transporters specifically transport reduced L-ascorbic acid against a concentration gradient using the intracellular sodium gradient to drive ascorbate transport. Svct1 is expressed in epithelial cells in the intestine, upregulated in cellular models for intestinal epithelium and appears to be responsible for the import of dietary vitamin C from the intestinal lumen. The vitamin C imported from the intestine is present in plasma at approximately 50 uM, almost exclusively in the reduced form, and is transported to tissues to play a variety of roles. Svct2 imports reduced ascorbate from the plasma into very active tissues like the brain. Deletion in mice of the gene for Svct2 revealed that ascorbate is required for normal development of the lungs and brain during pregnancy. A high concentration of vitamin C in neurons of the developing brain may help protect the developing brain from free radical damage. The oxidized form of ascorbate, dehydroascorbic acid, is transported into a variety of cells by the glucose transporter Glut-1. Glut-1, Glut-3, and Glut-4 can transport dehydroascorbate, but may not transport significant quantities of ascorbic acid in vivo. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014774
Subclass_of: Homeostasis Regulation Pathway
Synonym: Vitamin C in the Brain
Tree Number: T4.8.26.29
database_cross_reference: NCI:C39267
database_cross_reference: NCI_BioC:C39267

hSWI-SNF Pathway
type: Class
subclass of: Regulatory Pathway
definition: The eukaryotic genome is packaged by histone and nonhistone proteins to form chromatin. The assembly of nucleosomes, as well as compaction of nucleosomal arrays into higher-order chromatin structures, creates a highly restrictive environment for nuclear processes that require access to DNA. The packaging of eukaryotic DNA into nucleosomes inhibits the access of factors to DNA and thus results in the repression of transcription, replication, and recombination. To counterbalance the repressive nature of chromatin, a variety of chromatin remodeling factors use the energy of ATP hydrolysis to facilitate the interaction of proteins with nucleosomal DNA. ATP dependent chromatin remodeling complexes are characterized by the presence of an ATPase subunit from the SNF2-like family of the DEAD/H (SF2) DNA-stimulated ATPases. The highly conservative hSWI/SNF multisubunit complexes contain hBRM or BRG1 ATPases which alter the histone-DNA contacts enabling the access of general transcription factors to promoter regions. Remodeling complexes are targeted to promoters via interactions with sequence-specific transcription factors. Since chromatin constitutes a barrier for processes affecting DNA, such a transcription, replication, and repair, a mechanism is required that can open up or remodel chromatin to make it accessible to replication and transcription factors. Steroid receptors are a class of transcription factors that can interact with the repressive chromatin structure and remodel the chromatin to allow other transcription factors to bind. In addition to nuclear receptors, transcription activators as divergent as erythroid Kruppel-like factor, C/EBPs, c-Myc, MyoD, HSF1, and EBNA2 have also been found to recruit SWI/SNF to specific promoters. The role of steroid receptors in chromatin remodeling and transcription is exemplified by the glucocorticoid receptor (GR)-mediated transactivation of the mouse mammary tumor virus (MMTV) promoter. The MMTV promoter is organized into a …
PMOID: PMO:00014775
Subclass_of: Regulatory Pathway
Synonym: Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes
Tree Number: T4.8.27
database_cross_reference: NCI:C39109
database_cross_reference: NCI_BioC:C39109

Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014776
Subclass_of: Regulatory Pathway
Synonym: Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Tree Number: T4.8.28
database_cross_reference: NCI:C91609
database_cross_reference: NCI_PID:C91609

HIF-1-Alpha Transcription Factor Pathway
type: Class
subclass of: Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway
PMOID: PMO:00014777
Subclass_of: Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway
Synonym: HIF-1-alpha transcription factor network
Tree Number: T4.8.28.1
database_cross_reference: NCI:C91610
database_cross_reference: NCI_PID:C91610

IFN-Beta Enhancer Pathway
type: Class
subclass of: Regulatory Pathway
definition: The packaging of eukaryotic DNA into nucleosomes inhibits the access of factors to DNA and results in the repression of transcription, replication, and recombination. Local modification of histones on enhancers and promoters is required to activate gene expression. The transcription factors that bind to nucleosome-free regions of DNA or to DNA within nucleosomes recruit two types of enzymatic activities that modify the surrounding chromatin architecture. Chromatin remodeling machines, such as SWI/SNF complex, alter the structure of the pronucleosome in an ATP-dependent manner, and often cause nucleosome sliding. The second type of chromatin modifying complexes recruited by transcription factors covalently modify the N-terminal tails of histones by adding or removing phosphate, methyl, or acetyl groups. Virus-induced transcription of the human interferon-beta gene illustrates one of the best-characterized examples of the mechanisms by which the information contained in the DNA is transferred to the histone-N termini by generating novel adhesive surfaces required for the recruitment of transcription complexes. Upon virus infection, the gene is switched on by three transcription factors (NF-kB, IRFs, and ATF-2/c-Jun), and an architectural protein (HMG I(Y)), all of which bind cooperatively to the nucleosome-free enhancer DNA to form an enhanceosome. The enhanceosome targets the modification and repositioning of a nucleosome that blocks the formation of a transcriptional preinitiation complex on the IFN-beta promoter. This is accomplished by the ordered recruitment of HATs, SWI/SNF, and basal transcription factors. Initially, the PCAF HAT-containing complex is recruited, and it acetylates the nucleosome. This is followed by the recruitment of the CBP-PolII holoenzyme complex. The bromodomain containing transcription complexes SWI/SNF and TFIID are recruited to the promoter via bivalent interactions between the enhanceosome and specifically acetylated histone N termini. …
PMOID: PMO:00014778
Subclass_of: Regulatory Pathway
Synonym: The information-processing pathway at the IFN-beta enhancer
Tree Number: T4.8.29
database_cross_reference: NCI:C39183
database_cross_reference: NCI_BioC:C39183

Immune Response Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: An elaboration of the sequence of events that play a role in organismal defense responses.
PMOID: PMO:00014779
Subclass_of: Regulatory Pathway
Tree Number: T4.8.30
database_cross_reference: NCI:C39698

4-1BB-Dependent Immune Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The activation of T cells requires a co-stimulatory signal with T cell receptor activation, provided in many cases by activation of CD28 in resting T cells. 4-1BB (CD137) is a member of the TNF receptor gene family that provides another T cell co-stimulatory signal. 4-1BB is expressed by activated cytotoxic and helper T cells and its expression is induced by a variety of T cell stimuli, including activation of the T cell receptor or stimulation with mitogens. The ligand for 4-1BB (4-1BBL) is induced on activated antigen-presenting cells including macrophages, activating T cells expressing 4-1BB. Mice lacking 4-1BB survive and have an altered though functional immune response. T cells of mice lacking 4-1BB proliferate more rapidly than normal T cells, but have reduced cytokine secretion. The costimulatory signal provided by 4-1BB may act in combination with CD28 activation to prolong the T cell response, and may also act independently of CD28. Stimulation of T cells with the 4-1BB ligand may provide a therapeutic immune response in the treatment of cancer or viral infection. 4-1BB in T cells activates several signaling pathways. Like other members of the TNF receptor family, the 4-1BB receptor does not have an intrinsic kinase activity. TRAF2 is a signaling adapter that mediates signaling by other members of the TNF receptor family and that also binds to the cytoplasmic domain of ligand activated 4-1BB to activate intracellular kinase cascades. TRAF1 also binds to the cytoplasmic domain of 4-1BB although with lower affinity than TRAF2. One downstream effector activated by 4-1BB through TRAF2 is the transcription factor NF-kB. 4-1BB also activates map kinase pathways, including p38 and JNK activation. ASK1 dependent pathways can activate both p38 and JNK, and dominant negative ASK1 blocks their activation. Other kinase pathways may also be involved in 4-1BB activation of p38 and JNK, such as activation of germinal center kinase (GCK) or related kinases involved in act…
PMOID: PMO:00014780
Subclass_of: Immune Response Regulation Pathway
Synonym: The 4-1BB-dependent immune response
Tree Number: T4.8.30.1
database_cross_reference: NCI:C39277
database_cross_reference: NCI_BioC:C39277

Adhesion Molecules on Lymphocyte Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: B cell and T cell lymphocytes interact with a variety of cells as part of their immune function, circulating and homing in on specific stimuli in tissues like inflammatory signals. The interaction of lymphocytes with other cell types like vascular endothelial cells requires transmembrane adhesion molecules like VLA-4, LFA-1, CD44, CD31 and L-selectin. Each of these lymphocyte adhesion molecules interacts with specific ligands expressed on cells like endothelial cells to moderate adhesion between cells. CD44 is an adhesion molecule with many roles, including interaction of leukocytes with endothelial cells in response to inflammation, with the most often studied ligand being hyaluronan, a component of the extracellular matrix. LFA-1, Leukocyte function-associated molecule 1, is an integrin composed of two subunits, CD11a and CD18. LFA-1 moderates adhesion of lymphocytes with other cells and also transduces signals into cells through interaction with ICAM-1 expressed on endothelial cells. Expression of ICAM-1 (CD54) is increased by inflammatory signals, increasing adhesion and permeation of lymphocytes into inflamed tissues. VLA-4 is another integrin expressed on lymphocytes that plays a role in adhesion through interaction with its adhesion partner on endothelial cells, VCAM-1. L-selectin appears to mediate adhesion through binding of a lectin-like domain to carbohydrates. PECAM-1 (CD31) is expressed on endothelial cells and is involved in angiogenesis as well as adhesion between cells. VAP-1 is an additional protein expressed by lymphocytes and involved in adhesion to vascular endothelial cells. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014781
Subclass_of: Immune Response Regulation Pathway
Synonym: Adhesion Molecules on Lymphocyte
Tree Number: T4.8.30.2
database_cross_reference: NCI:C91303
database_cross_reference: NCI_BioC:C91303

Allergy Chemokine Network Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The inflammatory response associated with asthma is characterized by the recruitment of eosinophils from the bronchial microcirculation in response to the regulated local production of chemoattractant molecules. Although several chemical mediators are active upon eosinophils in vitro, a central role in eosinophil accumulation in vivo is emerging for the C-C chemokine eotaxin, which was first identified in a guinea pig model of allergic airway inflammation using protein purification and microsequencing. Eotaxin is the dominant eosinophil-selective chemoattractant in this model, acting to cause both local eosinophil recruitment to the lung, and the release of a rapidly mobilizable pool of bone marrow eosinophils in cooperation with IL-5. Eotaxin and eotaxin-2 are potent stimulators of eosinophils, signaling exclusively via high affinity binding to the receptor CCR3. C-C chemokines, including MCP-3, MCP-4, and RANTES, also stimulate eosinophils via CCR3, although they show less leukocyte selectivity as they additionally signal via other chemokine receptors expressed on a range of leukocytes, including lymphocytes and monocytes. CCR3 is expressed in high numbers on eosinophils and is thought to be the major eosinophil chemokine receptor. Blockade of CCR3 in vivo inhibits eosinophil recruitment in response to eotaxin in both the guinea pig and mouse. More recently, CCR3 expression has been demonstrated on basophils and Th2-type T cells, suggesting possible roles for CCR3 in the genesis and maintenance of allergic inflammation. CCR3 is therefore a major target for anti-inflammatory drug development. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014782
Subclass_of: Immune Response Regulation Pathway
Synonym: The Role of Eosinophils in the Chemokine Network of Allergy
Tree Number: T4.8.30.3
database_cross_reference: NCI:C39064
database_cross_reference: NCI_BioC:C39064

Alternative Complement Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The complement system of plasma proteins is an important part of the immune system that forms a cascade of factors that lyses foreign cells. There are two branches of the complement system, the classical pathway that is initiated by antibody-antigen complexes on a cell and the alternative pathway that is antibody independent. The ultimate result in either pathway is the creation of the membrane attack complex, a large pore in the cell membrane that results in cell lysis. The alternative pathway starts with the spontaneous conversion of C3 to an active protease. C3 contains a thioester group that is spontaneously hydrolyzed at a slow rate to create C3(H2O). From there, binding of factor B (Fb) and activation by factor D (Fd) cleaves factor B to create the active protease C3 convertase (AP convertase). This enzyme cleaves C3 to form C3b, which can go on to form a C5 activating convertase. At this point the alternative pathway proceeds in the same manner as the classical pathway, recruiting additional complement factors (C6, C7, C8 and C9) to ultimately form the membrane attack complex and lyse the associated cell. One question about the alternative pathway is how the spontaneous activation of C3 in plasma leads to the lysis of specific cells in the absence of antibody on the cell surface. Active C3b binds to the cell surface, particularly to complement activators like cell wall components and lipopolysaccharide. A constant low level of spontaneous C3b formation ensures that C3b can bind to invading cells and trigger the rest of the alternative complement pathway to lyse the cells even in the absence of an antibody response. The constant low level of C3b activation and potential activation of the alternative pathway is kept in check by a natural damper, factor H and factor I. Factors H and I in plasma inactivate C3b enzyme in solution. Factors H and I cannot inactivate C3b on the cell surface due to protection by properdin, ensuring that the alternative pathway is prim…
PMOID: PMO:00014783
Subclass_of: Immune Response Regulation Pathway
Synonym: Alternative Complement Activation Pathway
Synonym: C76 COMPLEMENT ACTIVATION ALTERNATIVE PATHWAY
Synonym: COMPLEMENT ACTIVATION ALTERNATIVE PATHWAY
Synonym: Complement Activation Pathway, Alternative
Synonym: Complement Pathway, Alternative
Synonym: Complement activation alternative pathway
Synonym: Complement activation alternative pathway (function)
Synonym: Complement activation alternative pathway, NOS
Synonym: Complement activation alternative pathway, function
Synonym: Complement activation alternative pathway, function (observable entity)
Tree Number: T4.8.30.4
database_cross_reference: CSP:5004-0002
database_cross_reference: GO:GO:0006957
database_cross_reference: MSH:D003170
database_cross_reference: NCI:C38983
database_cross_reference: NCI_BioC:C38983
database_cross_reference: SNMI:F-C7600
database_cross_reference: SNOMEDCT_US:86091003

Antigen Dependent B Cell Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: A key part of the immune system is the production of immunoglobulins (antibodies) by B cells to bind and inactivate specific foreign antigens. The body produces B cells with a wide range of antigen specificities in their immunoglobulin B cell receptor, but each cell only has a single specificity. When the B cell receptor immunoglobulin binds antigen, that cell is activated to proliferate and create plasma cells secreting immunoglobulins to bind that specific antigen. B cell activation also creates memory cells with the same antigen specificity that do not actively secrete immunoglobulin but provide for rapid future immune responses to the same antigen. B cells are not activated by antigen on their own, but require interaction with helper CD4+ T cells to become activated and proliferate. The B cell first expresses immunoglobulin on the cell surface as the B cell receptor. If the B cell receptor immunoglobulin binds specific antigen, then the cell internalizes the antigen and presents it to T cells in MHC II, where it is recognized by the T cell receptor. In addition to the interaction between the T cell receptor and the B cell MHC-antigen, T cell interaction with the B cell involves additional positive and negative regulatory signals. CD40 interaction with CD40L and CD28 interaction with CD80 provide positive costimulatory signals that stimulate B cell activation and proliferation. T cell receptor activation induces expression of molecules like the CD40 ligand that modulate the B cell-T cell interaction. The CD40-CD40L interaction induces cytokine production and expression of other genes and alters the fate of the B cell involved in the interaction. If the interaction between CD40 and CD40L is prolonged, the B cell can be induced to become a memory cell rather than a plasma cell. Fas ligand binding to Fas between B and T cells may negatively modulate B cell activation, inducing apoptosis that limits B cell proliferation and activation. Cytokines like IL-2, IL-4 and I…
PMOID: PMO:00014784
Subclass_of: Immune Response Regulation Pathway
Synonym: Antigen Dependent B Cell Activation
Tree Number: T4.8.30.5
database_cross_reference: NCI:C38994
database_cross_reference: NCI_BioC:C38994

Antigen Presentation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Invariant chain (Ii) associates with newly synthesized class II molecules in the endoplasmic reticulum (ER), an interaction that has been shown to interfere with peptide binding to class II molecules. The class II-associated invariant chain peptide (CLIP) region (residues 81-104) of Ii is believed to mediate this inhibition by engaging the binding domain of class II like an antigenic peptide. Together, these findings have given rise to a model in which CLIP association with the class II groove acts to prevent inappropriate presentation of peptides imported into the ER for association with major histocompatibility complex class I molecules. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014785
Subclass_of: Immune Response Regulation Pathway
Synonym: Antigen Processing and Presentation
Tree Number: T4.8.30.6
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39153
database_cross_reference: NCI_BioC:C39153

Antigen Processing and Presentation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
PMOID: PMO:00014786
Subclass_of: Immune Response Regulation Pathway
Synonym: Antigen processing and presentation
Tree Number: T4.8.30.7
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91433
database_cross_reference: NCI_KEGG:C91433

B Cell Receptor Complex Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: B cells produce immunoglobulins (Ig, antibodies) that specifically bind antigen molecules. B cells first produce a membrane-bound form of immunoglobulin, the B cell receptor, as part of B cell differentiation. Each B cell expresses one immunoglobulin but the population of B cells in each individual display a wide variety of antigen specificity, with each cell expressing Ig on its surface as part of the B cell receptor complex. When the B cell receptor binds to antigen, it initiates a signal through other proteins non-covalently associated with it in the B cell receptor complex, the Ig-alpha (CD79a) and Ig-beta (CD79b) chains. The signal initiated by binding of antigen to the B cell receptor complex causes growth and proliferation of the B cell and the creation of an amplified clone of effector cells that secrete the antigen-specific immunoglobulin. Activation of the B cell receptor by antigen also results in the production of memory cells that persist in circulation to produce a more rapid immune response after future challenges by the same antigen. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014787
Subclass_of: Immune Response Regulation Pathway
Synonym: B Cell Receptor Complex
Tree Number: T4.8.30.8
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91309
database_cross_reference: NCI_BioC:C91309

B Cell Receptor Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
PMOID: PMO:00014788
Subclass_of: Immune Response Regulation Pathway
Synonym: B cell receptor signaling pathway
Synonym: B cell receptor signalling pathway
Synonym: B lymphocyte receptor signaling pathway
Synonym: B lymphocyte receptor signalling pathway
Synonym: B-cell receptor signaling pathway
Synonym: B-cell receptor signalling pathway
Synonym: B-lymphocyte receptor signaling pathway
Synonym: B-lymphocyte receptor signalling pathway
Synonym: BCR Immune Response Signaling Pathway
Synonym: BCR Signaling Pathway
Tree Number: T4.8.30.9
database_cross_reference: GO:GO:0050853
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39005
database_cross_reference: NCI:C91456
database_cross_reference: NCI:C91551
database_cross_reference: NCI_BioC:C39005
database_cross_reference: NCI_KEGG:C91456
database_cross_reference: NCI_PID:C91551

B Lymphocyte Cell Surface Molecule Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: B cells must communicate with their environment to participate in the immune system as the source of antigen-specific immunoglobulins. Cell surface proteins on B cells receive signals from the exterior, adhere to other cells, and transmit signals to other cells. Antigen recognized by a B cell's immunoglobulin is presented in MHC Class II to T cells during B cell activation. Cell surface immunoglobulins are a key to B cell function, assisting in the response of B cells to specific antigen recognized by that cell's immunoglobulin. CD54 (ICAM-1) is an adhesion molecule involved in the binding of B cells to other cell types and LFA-1 is an integrin adhesion protein with two subunits that binds to ICAM. CD35 and CD21 are receptors for complement factors that stimulate the B cell response when complement is activated. CD80 and CD40 bind to T cell proteins (CD28 and CD40L, respectively) to provide costimulatory signals in the B cell-T cell interaction required for B cell activation. CD45 is a protein tyrosine phosphatase that regulates activation of B cells and T cells through dephosphorylation of signaling factors. CD32 is a receptor for IgG Fc, and is also called Fc gamma RII. The number of proteins on the surface of B cell proteins indicates the complexity of regulation of B cell activation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014789
Subclass_of: Immune Response Regulation Pathway
Synonym: B Lymphocyte Cell Surface Molecules
Tree Number: T4.8.30.10
database_cross_reference: NCI:C91310
database_cross_reference: NCI_BioC:C91310

B-Cell Immune Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: APRIL and BAFF (also called TALL-I and BLyS) are TNF family members that act as ligands for the BCMA and TACI receptors. Both APRIL and BAFF bind to both the BCMA and TACI receptors to activate the humoral immune response, stimulating B cell immunoglobulin production and proliferation. BAFF is found as a membrane bound form in T cells and a soluble form that is released from the cell to stimulate B cell proliferation and differentiation. As members of the TNF receptor gene family, BCMA and TACI interact with TRAF family members to transduce signals downstream to NF-kappaB activation and MAP kinase pathways. Abnormally active BAFF or APRIL signaling may play a role in autoimmune disorders such as lupus. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014790
Subclass_of: Immune Response Regulation Pathway
Synonym: TACI and BCMA stimulation of B cell immune responses
Tree Number: T4.8.30.11
database_cross_reference: NCI:C39243
database_cross_reference: NCI_BioC:C39243

B-Cell Survival Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Physical interactions between integrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignant B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, survivin, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014791
Subclass_of: Immune Response Regulation Pathway
Synonym: B Cell Survival Pathway
Tree Number: T4.8.30.12
database_cross_reference: NCI:C39004
database_cross_reference: NCI_BioC:C39004

BCR Immune Response Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
PMOID: PMO:00014792
Subclass_of: Immune Response Regulation Pathway
Synonym: B Cell Receptor Signaling Pathway
Synonym: B cell receptor signaling pathway
Synonym: B cell receptor signalling pathway
Synonym: B lymphocyte receptor signaling pathway
Synonym: B lymphocyte receptor signalling pathway
Synonym: B-cell receptor signaling pathway
Synonym: B-cell receptor signalling pathway
Synonym: B-lymphocyte receptor signaling pathway
Synonym: B-lymphocyte receptor signalling pathway
Synonym: BCR Signaling Pathway
Tree Number: T4.8.30.13
database_cross_reference: GO:GO:0050853
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39005
database_cross_reference: NCI:C91456
database_cross_reference: NCI:C91551
database_cross_reference: NCI_BioC:C39005
database_cross_reference: NCI_KEGG:C91456
database_cross_reference: NCI_PID:C91551

Bystander B Cell Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Expression of Fas-Ligand by T cells can induce apoptosis through interaction with Fas on the target cell. A target of Fas-mediated apoptosis is the B cell. B cells that are not activated by antigen, bystander B cells, can interact through CD40 with the CD40 ligand on T cells. The CD40-CD40L interaction induces Fas expression by bystander B cells, and the interaction of Fas with the T cell Fas-Ligand, followed by B cell apoptosis. B cells that are activated by antigen binding and that interact with the T cell receptor through the B cell MHC II appear to become resistant to Fas-mediated apoptosis, survive and proliferate. IL-4 also appears to confer B cell resistance to Fas-mediated apoptosis. The induction of apoptosis in non-antigen stimulated B cells may prevent B cells from proliferating inappropriately and failure of this mechanism may be involved in autoimmune disorders and B cell lymphomas. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014793
Subclass_of: Immune Response Regulation Pathway
Synonym: Bystander B Cell Activation
Tree Number: T4.8.30.14
database_cross_reference: NCI:C39003
database_cross_reference: NCI_BioC:C39003

Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes
type: Class
subclass of: Immune Response Regulation Pathway
PMOID: PMO:00014794
Subclass_of: Immune Response Regulation Pathway
Synonym: Role of Calcineurin-dependent NFAT signaling in lymphocytes
Tree Number: T4.8.30.15
database_cross_reference: NCI:C91556
database_cross_reference: NCI_PID:C91556

Calcineurin-Regulated NFAT-Dependent Transcription Pathway
type: Class
subclass of: Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes
PMOID: PMO:00014795
Subclass_of: Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes
Synonym: Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Synonym: Lymphocyte NFAT-Dependent Transcription Pathway
Tree Number: T4.8.30.15.1
database_cross_reference: NCI:C91740
database_cross_reference: NCI_PID:C91740

Chemokine Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
PMOID: PMO:00014796
Subclass_of: Immune Response Regulation Pathway
Synonym: Chemokine signaling pathway
Tree Number: T4.8.30.16
database_cross_reference: NCI:C91487
database_cross_reference: NCI_KEGG:C91487

Classical Complement Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The complement system is part of the defense against invading cells and is composed of about twenty different proteins found in the plasma. When activated, complement proteins form a pathway of proteolytic reactions that culminates in the lysis of foreign cells. The complement system also stimulates phagocytosis of foreign cells and an inflammatory response. There are two different complement systems, the classical complement pathway initiated by antibody complexes on the cell surface, and an alternative complement pathway that is initiated without antibodies. The complement system proteins are named with a capital C followed by a number. A small letter after the number indicates that the protein is a smaller protein resulting from the cleavage of a larger precursor by a protease. In the classical pathway, the first step is the initiation of the pathway triggered by recognition by complement factor C1 of antigen-antibody complexes on the cell surface. When C1 complex interacts with aggregates of IgG with antigen on a cell's surface, two C1-associated proteases, C1r and C1s, are activated. Other factors like lipopolysaccharide also activate C1s. Once C1s is activated, it cleaves C4 to form C4b that then binds to the cell membrane of the cell being attacked. The proteolytic complement cascade is then amplified on the cell membrane through sequential cleavage of complement factors and recruitment of new factors until a cell surface complex containing C5b, C6, C7, and C8 is formed. The addition of a multiple C9 proteins creates the membrane attack complex results in a large pore that spans the membrane of the cell being attacked, allowing ions to flow freely between the cellular interior and exterior. Ions flow out, but large molecules stay in, causing water to flood into the cell and ultimately burst the cell from osmotic pressure. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014797
Subclass_of: Immune Response Regulation Pathway
Synonym: Classical Complement Activation Pathway
Synonym: Complement Activation Pathway, Classical
Synonym: Complement Pathway, Classical
Synonym: classical complement pathway
Tree Number: T4.8.30.17
database_cross_reference: CSP:5004-0017
database_cross_reference: MSH:D003171
database_cross_reference: NCI:C39032
database_cross_reference: NCI_BioC:C39032

Complement and Coagulation Cascade
type: Class
subclass of: Immune Response Regulation Pathway
definition: The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsinization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning.
PMOID: PMO:00014798
Subclass_of: Immune Response Regulation Pathway
Synonym: Complement and coagulation cascades
Tree Number: T4.8.30.18
database_cross_reference: NCI:C91511
database_cross_reference: NCI_KEGG:C91511

Complement Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The complement pathway consists of a series of over thirty proteins in plasma that are part of the immune response. Activation of the complement system lyses bacterial cells, forms chemotactic peptides (C3a and C5a) attracting immune cells, and increases phagocytotic clearance of infecting cells. Complement can also increase the permeability of vascular walls and cause inflammation. Most complement proteins exist in plasma as inactive precursors that cleave and activate each other in a proteolytic cascade in response to three different mechanisms by which the complement system is activated, the classical pathway, the alternative pathway and the lectin-induced pathway. These three systems are distinct in the initiation of the proteolytic cascade but share most of their components and all three converge in the creation of a C3 convertase that cleaves the C3 complement protein, leading ultimately to the formation of the membrane attack complex, MAC, a pore causing lysis of cells. The classical pathway is activated by the recognition of foreign cells by antibodies bound to the surface of the cells. The alternative and lectin-induced pathways are both antibody independent. Proteolysis is triggered in the alternative pathway by the spontaneous activation of C3 convertase from C3 and is triggered in the lectin-induced pathway by the recognition of carbohydrates on the bacterial cell surface by mannan-binding protein, Mbp. In addition to providing a key part of the response to bacterial infection, the complement system can be involved in the response to fungi, viruses and protists. While activation of the complement system is a key part of the immune system, it must also be kept in check to prevent inappropriate or exaggerated responses. Twelve different proteins have been identified that inhibit complement activation to control the system, including Factor H, Factor I and C1 inhibitor. Deficiencies in components of the complement system have been identified in humans that …
PMOID: PMO:00014799
Subclass_of: Immune Response Regulation Pathway
Synonym: complement pathway
Synonym: complement pathways
Tree Number: T4.8.30.19
database_cross_reference: CHV:0000057794
database_cross_reference: CSP:1557-8754
database_cross_reference: NCI:C39033
database_cross_reference: NCI_BioC:C39033

CSK Protein Kinase Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Interaction of T cell receptor with specific antigen in the context of MHC II activates a signal transduction pathway that leads to T cell activation. In the T cell receptor signaling pathway, the src family kinases Lck and Fyn are activated to phosphorylate proteins in the T cell receptor complex which recruit and activate the ZAP70 kinase. The activation of ZAP70 phosphorylates downstream targets that activate MAP kinase pathways and cause T cell activation. The CD45 phosphorylase also plays a role in T cell receptor signaling, dephosphorylated Lck and Fyn to activate them. Other factors modulate T cell receptor activation. Csk (COOH-terminal Src kinase) phosphorylates Lck and deactivates it, opposing the action of CD45. The phosphorylation of Lck by Csk inhibits T cell receptor signaling and inhibits T cell activation. Csk activity is regulated in T cells by PKA, the cAMP-dependent protein kinase activated by the second messenger cAMP. The activity of Csk also appears to depend on other factors such as CBP, which recruits Csk to the plasma membrane in lipid rafts where other signaling factors such the T cell receptor complex are localized. CBP also directly activates Csk. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014800
Subclass_of: Immune Response Regulation Pathway
Synonym: Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
Tree Number: T4.8.30.20
database_cross_reference: NCI:C39038
database_cross_reference: NCI_BioC:C39038

CTL-mediated Immune Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Cytotoxic T lymphocytes (CTLs), also known as killer T cells, provide a cell-mediated response to specific foreign antigens associated with cells. CTLs only respond to foreign antigen when it is presented bound to the MHC-1 expressed on the surface of cells. CTLs do not respond to soluble antigen, but induce apoptosis in viral-infected cells and in cancer cells. When the complex of antigen bound to MHC-1 is bound to antigen-specific T cell receptor, the cytotoxic T cell induces apoptosis in the target cell primarily by two pathways, one involving perforin-mediated apoptosis and the other involving Fas/Fas-ligand interaction. When CTLs are activated by recognition of specific antigen on a cell, they release perforin proteins that integrate into the membrane of the target cell and organize to form a membrane pore. This allows the protease granzyme to enter the cell and activate the apoptotic caspase proteolytic cascade, and also allows other molecules to cross the cell membrane and trigger osmotic lysis of the membrane. The interaction of T-cell Fas ligand with the Fas receptor in the target cell can also activate the caspase cascade and other pathways involved in apoptosis. The interaction of a CTL with antigen-MHC I complex activates the CTL to proliferate and amplify the clone of T cells that respond to that antigen, amplifying the immune response against that specific antigen. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014801
Subclass_of: Immune Response Regulation Pathway
Synonym: CTL mediated immune response against target cells
Tree Number: T4.8.30.21
database_cross_reference: NCI:C39042
database_cross_reference: NCI_BioC:C39042

Cytokine Network Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Several different cell types coordinate their efforts as part of the immune system, including B cells, T cells, macrophages, neutrophils, basophils and eosinophils. Each of these cell types has a distinct role in the immune system, and each communicates with other immune cells using secreted factors called cytokines, including interleukins, TNF, and the interferons. Macrophages phagocytose foreign bodies and are antigen-presenting cells, using cytokines to stimulate specific antigen dependent responses by B and T cells and non-specific responses by other cell types. T cells secrete a variety of factors to coordinate and stimulate immune responses to specific antigen, such as the role of helper T cells in B cell activation in response to antigen. The proliferation and activation of eosinophils, neutrophils and basophils respond to cytokines as well. Cytokine communication is often local, within a tissue or between cells in close proximity. Each of the cytokines is secreted by one set of cells and provokes a response in another target set of cells, often including the cell that secretes the cytokine. Some cytokines, like IL-1, interferons and TNF, stimulate a broad inflammatory response in response to infection or injury. Other cytokines have more specific functions such the following examples. IL-2 stimulates the proliferation and activation of B and T cells. IL-4 plays a role in the differentiation of Th2 cells, in allergic responses, and in the switching of antibody types. IL-5 stimulates the production and maturation of eosinophils during inflammation. IL-8 is a chemokine, a chemotactic factor that attracts neutrophils, basophils and T cells to sites of inflammation. IL-12 and IL-18 are involved in helper T cell differentiation. IL-10 apparently acts to repress secretion of proinflammatory cytokines. The complex interplay of these different cytokine functions with immune cells is essential for correct immune function. (This definition may be outdated - see the Des…
PMOID: PMO:00014802
Subclass_of: Immune Response Regulation Pathway
Synonym: Cytokine Network
Tree Number: T4.8.30.22
database_cross_reference: NCI:C39044
database_cross_reference: NCI_BioC:C39044

Cytotoxic T Cell Surface Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Cytotoxic T cells are a key part of the cellular immune response, killing cells that display foreign antigen on their surface, primarily virus-infected cells. Transformed cells can also be detected and eliminated by cytotoxic T cells. There are two mechanisms by which activated cytotoxic T cells kill cells presenting specific antigen. One method involves the release of secretory granules containing perforin and granzyme to induce lysis of the targeted cell. Cytotoxic T cells also express Fas ligand to bind to Fas on target cells and induce apoptosis. Communication with and interaction with other cell types is essential for cytotoxic T cell function. Distinct types of T cells are characterized and their activities determined by the proteins they express on their cell surface. Cytotoxic T cells will only respond to antigen presented on the surface of cells bound to MHC I proteins, not antigens present in solution. The T cell receptor, with the multiprotein CD3 complex, is responsible for the recognition of specific antigens, triggering the activation and proliferation of cells. Cytotoxic T cell activation also requires additional signals provided by helper T cells in addition to signals provided by antigen-presenting cells. Thy1 provides a general marker of T cells, and the presence of CD8 protein that binds to MHC distinguishes cytotoxic T cells from CD4 positive helper T cells. CD28 expressed by T cells acts as a costimulatory signal with the T cell receptor when it binds its ligand, a B-7 coreceptor, on antigen-presenting cells (see The Co-Stimulatory Signal During T-cell Activation). Inappropriate regulation of the costimulatory signal can lead to too great or too small of an immune response. Interaction of activated cytotoxic T cells is aided by increased expression of LFA-1, a cell-adhesion molecule that binds to ICAM on target cells. CD2 is a T cell adhesion molecule. Mice with a disrupted CD2 gene are largely normal and appear to have a normal immune system, b…
PMOID: PMO:00014803
Subclass_of: Immune Response Regulation Pathway
Synonym: T Cytotoxic Cell Surface Molecule Pathway
Synonym: T Cytotoxic Cell Surface Molecules
Tree Number: T4.8.30.23
database_cross_reference: NCI:C91305
database_cross_reference: NCI_BioC:C91305

Dendritic Cell Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: While T cells and B cells carry out the actions of antigen-specific immune responses, antigen-presenting cells called dendritic cells are required for this to happen. The name of dendritic cells is based on their shape, with activated dendritic cells displaying long processes on their surface. When immature dendritic cells found throughout the body internalize and present antigen, they express markers that stimulate the activation of lymphocytes, and migrate to lymphocyte rich tissues like the spleen and lymph nodes to initiate immune responses. In addition to stimulating responses against antigens, dendritic cells also produce tolerance to self antigens. Dendritic cells can be derived from either myeloid or lymphoid lineages. Monocyte (myeloid) derived lineages (pDC1) stimulate Th1 cell differentiation while plasmacytoid (lymphoid) dendritic cells (pDC2) induce Th2 cell differentiation. Factors that stimulate the maturation of monocytes derived dendritic cells include GM-CSF, and IL-4. IL-3 stimulates the differentiation of pDC2 cells into DC2 cells. A variety of factors are involved in antigen-recognition and processing by immature dendritic cells and in the maturation of these cells. The transition to mature dendritic cells down-regulates the factors involved in antigen internalization, and increases the expression of MHC, costimulatory molecules involved in lymphocyte activation, adhesion molecules, and specific cytokines and chemokines. Toll-like receptors on the surface of immature dendritic cells recognize microbial components to induce dendritic cell maturation. In addition to stimulating B cell responses, dendritic cells are potent activators of T cells. IL-12 secretion by dendritic cells stimulates T cell responses, particularly differentiation of Th1 cells that produce interferon-gamma and other pro-inflammatory cytokines. While IL-4 generally stimulates Th2 differentiation, the stimulation of Th2 cell formation by DC2 cells does not appear to involve IL-…
PMOID: PMO:00014804
Subclass_of: Immune Response Regulation Pathway
Synonym: Dendritic cells in regulating TH1 and TH2 Development
Tree Number: T4.8.30.24
database_cross_reference: NCI:C39048
database_cross_reference: NCI_BioC:C39048

dsRNA Induction Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: One defense against viral infection is provided by PKR, double-stranded RNA activated protein kinase. When PKR interacts with dsRNA found in cells during viral infection, PKR phosphorylates itself and cellular proteins including the translation factor elF2a and the transcription factor NF-kB. The repression of translation caused by phosphorylation of elF2a prevents cells from producing viral proteins and creating infectious viral particles. PKR phosphorylation of I-kB kinase activates NF-kB to induce transcription of inflammatory factors and stimulate an immune response that impedes viral infection. The PKR kinase is induced by interferon and some of the anti-viral activity of interferon may be mediated by PKR. Some viruses have evolved mechanisms to inactivate PKR to promote successful infection. Another substrate of PKR, the tumor suppressor p53, may be involved in potential PKR regulation of the cell cycle and apoptosis. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014805
Subclass_of: Immune Response Regulation Pathway
Synonym: Double Stranded RNA Induced Gene Expression
Tree Number: T4.8.30.25
database_cross_reference: NCI:C39224
database_cross_reference: NCI_BioC:C39224

Fc Epsilon Receptor I Signaling Pathway BioCarta
type: Class
subclass of: Immune Response Regulation Pathway
definition: The Fc Epsilon Receptor 1 signaling pathway in mast cells uses multiple core signal paths to achieve its necessary ends. Through the BTK protein and PKC Mast cells are able to degranulate, through the PKC and MAPK paths the cells are able to alter cytokine expression and arachidonic acid release. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014806
Subclass_of: Immune Response Regulation Pathway
Synonym: Fc Epsilon Receptor I Signaling in Mast Cells
Tree Number: T4.8.30.26
database_cross_reference: NCI:C39079
database_cross_reference: NCI_BioC:C39079

Fc Epsilon Receptor I Signaling Pathway KEGG
type: Class
subclass of: Immune Response Regulation Pathway
definition: Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
PMOID: PMO:00014807
Subclass_of: Immune Response Regulation Pathway
Synonym: Fc epsilon RI signaling pathway
Tree Number: T4.8.30.27
database_cross_reference: NCI:C91476
database_cross_reference: NCI_KEGG:C91476

Fc-Epsilon Receptor I Signaling Pathway PID
type: Class
subclass of: Immune Response Regulation Pathway
PMOID: PMO:00014808
Subclass_of: Immune Response Regulation Pathway
Synonym: Fc-epsilon receptor I signaling in mast cells
Tree Number: T4.8.30.28
database_cross_reference: NCI:C91595
database_cross_reference: NCI_PID:C91595

Hematopoietic Cell Lineage Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing this differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
PMOID: PMO:00014809
Subclass_of: Immune Response Regulation Pathway
Synonym: Hematopoietic cell lineage
Tree Number: T4.8.30.29
database_cross_reference: NCI:C91459
database_cross_reference: NCI_KEGG:C91459

IL10 Anti-inflammatory Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by activated macrophages. The IL-10 receptor is in the JAK/STAT class of receptors but activation of the JAK/STAT pathways by IL-10 does not appear on its own to be responsible for the anti-inflammatory properties of this cytokine. The anti-inflammatory actions of IL-10 appear to require induction of the enzyme heme oxygenase-1 (HO-1) through a map kinase pathway involving the p38 kinases. HO-1 is involved in the biosynthesis of heme, and catalyzes a reaction producing carbon monoxide, free iron, and the heme precursor biliverdin. HO-1 is induced by IL-10 and is also induced by oxidative stress. Blocking HO-1 with inhibitors or antisense blocks the anti-inflammatory actions of IL-10. The anti-inflammatory actions of HO-1 appear to be the result of signaling by the carbon monoxide it produces since removal of CO blocks the anti-inflammatory action of IL-10 and HO-1. The anti-inflammatory actions of IL-10 may be therapeutically useful either directly or through modulation of HO-1 activity. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014810
Subclass_of: Immune Response Regulation Pathway
Synonym: IL-10 Anti-inflammatory Signaling Pathway
Tree Number: T4.8.30.30
database_cross_reference: NCI:C39116
database_cross_reference: NCI_BioC:C39116

IL2RB Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells. This receptor is composed of three polypeptide chains, the alpha, beta, and gamma chains. The IL-2 receptor gamma chain is a common component for several other cytokine receptors, including IL-4, IL-7, IL-9 and IL-15. The IL-2 receptor beta chain is essential for IL-2 signaling and is also a component of the IL-15 receptor complex. The polypeptides of the IL-2 receptor do not themselves have intrinsic catalytic activity, but interact with cytoplasmic signaling proteins to transduce signals. Different regions of the cytoplasmic domain of the IL-2 receptor beta chain interact and couple with distinct signaling pathways and cellular responses. JAK1 associates with the beta chain and JAK3 with the gamma chain. Binding of IL-2 induces heterodimerization of receptor subunits, and activation of JAK kinase activity. Tyrosine residues in the beta chain cytoplasmic domain are phosphorylated during activation, recruiting other factors to the phosphorylated tyrosine residues through src homology 2 (SH2) domains. The adaptor protein Shc binds to phosphorylated tyrosine 338 of the beta chain. When bound, Shc is phosphorylated and couples through Grb2 and Sos-1 to activate Ras and stimulate T cell proliferation. Another key proliferative pathway activated by IL-2 is phosphorylation of STAT-5 by JAK kinases. STAT-5 is recruited to IL-2 beta phosphorylated tyrosines at multiple positions, including Y338, Y392 and Y510. Once phosphorylated, STAT-5 enters the nucleus to regulate the transcription of several genes, some proliferative, such as cyclin genes, and others that are involved in T cell immune function such as cytokine genes. The suppressors of cytokine activation, SOCS-3 and SOCS-1, oppose phosphorylation and activation of STAT-5 and JAK1 caused by IL-2. PI3 kinase is another protein recruited to IL-2 receptor beta chain tyrosines when phosphoryl…
PMOID: PMO:00014811
Subclass_of: Immune Response Regulation Pathway
Synonym: IL-2 Receptor Beta Chain in T cell Activation
Tree Number: T4.8.30.31
database_cross_reference: NCI:C39123
database_cross_reference: NCI_BioC:C39123

Inflammatory Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead to destruction of tissues in autoimmune disorders and perhaps neurodegenerative or cardiovascular disease. Secreted cytokine proteins provide signals between immune cells to coordinate the inflammatory response. Some cytokines such as IL-1, IL-6, and TNF act to broadly provoke the inflammatory response while others act on specific types of immune cells. Macrophages and other phagocytotic cells provide a front-line defense against bacterial infection. Macrophages stimulate the inflammatory responses of neutrophils, fibroblasts, and endothelial cells in response to infection by secreting IL-1 and TNF. IL-1 and TNF cause fever through alteration of the body temperature set-point in the hypothalamus. Fibroblasts and endothelial cells respond to IL-1 and TNF by recruiting more immune cells to the site of inflammation. Secreted IL-8 is a chemokine that attracts neutrophils to sites of infection. Macrophages also present antigen to T helper cells that play a central role in coordinating immune responses. T helper cells induce clonal expansion of T cells that respond to antigen, with IL-2 as a key mediator of T cell proliferation and activation. TGF-beta is a negative regulator of proliferation in many cells, having anti-inflammatory actions in some settings. The cytotoxic activity of Natural Killer cells (NK cells) and lymphokine activated killer cells (LAK cells) toward viral infected or tumor cells is stimulated by IL-2 and other cytokines. T helpers secrete IL-3 and IL-5 to stimulate eosinophil proliferation and activation. Eosinophils are involved in the immune response to parasitic infection. T helper cells are required to stimulate B cell responses as well, with the cytokines IL-10, IL-4 a…
PMOID: PMO:00014812
Subclass_of: Immune Response Regulation Pathway
Synonym: Cytokines and Inflammatory Response
Tree Number: T4.8.30.32
database_cross_reference: NCI:C39129
database_cross_reference: NCI_BioC:C39129

Intestinal IgA Production Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-committed plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-beta, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
PMOID: PMO:00014813
Subclass_of: Immune Response Regulation Pathway
Synonym: Intestinal immune network for IgA production
Synonym: Pathway for IgA Production
Tree Number: T4.8.30.33
database_cross_reference: NCI:C91518
database_cross_reference: NCI_KEGG:C91518

Lectin Induced Complement Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The complement cascade of proteolytic factors involved in cellular lysis can be initiated by several different factors, including antibody-dependent and antibody-independent recognition of infectious organisms. In the lectin-induced complement cascade, carbohydrates on the surface of microbial cells activate the complement cascade by binding to mannan-binding lectin (also called the mannan-binding protein, Mbl/Mbp). Mbp is an acute phase serum protein whose expression is induced by microbial infection. The binding of Mbl to microbial ligands activates the Mbl associated serine proteases Masp1 and Masp2, triggering the cleavage of C2 and C4 to create C4bC2a, a C3 convertase that cleaves large numbers of C3. Masp1 and Masp2 are similar to the C1 protease in the classical complement pathway. Once formed the C3 convertase cleaves and activates the remaining complement factors leading ultimately to formation of a pore in the bacterial membrane by the membrane attack complex (MAC) that lyses the bacterial cell. The lectin-induced pathway also appears to play an important role of the activation of phagocytotic cells by infection. Although the initiating event activating the complement cascade is distinct in the lectin-induced pathway, from the C3 convertase onward the lectin induced complement pathway is the same as the classical complement pathway. Since antibodies are not required in the lectin-induced pathway, this aspect of the immune response is part of the innate immune response. The importance of this pathway to the immune response has been demonstrated by the identification of children and adults with little or no Mbl who lacked normal phagocytotic responses and are highly susceptible to infection. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014814
Subclass_of: Immune Response Regulation Pathway
Tree Number: T4.8.30.34
database_cross_reference: NCI:C39138
database_cross_reference: NCI_BioC:C39138

Leukocyte Transendothelial Migration Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Leukocyte migration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL/beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metalloproteinases and loss of VE-cadherin-mediated adhesion.
PMOID: PMO:00014815
Subclass_of: Immune Response Regulation Pathway
Synonym: Leukocyte transendothelial migration
Tree Number: T4.8.30.35
database_cross_reference: NCI:C91439
database_cross_reference: NCI_KEGG:C91439

Local Acute Inflammatory Response Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Inflammation has several distinct components, including the localized response at the site of tissue injury or infection. Tissue injury stimulates the release of inflammatory signaling molecules such as bradykinin. Bacterial infection stimulates an immune response in several ways. Bacteria that are phagocytosed can activate macrophages, causing the release of inflammatory cytokines such as IL-1, TNF, and IL-6. Bacteria can also activate the complement cascade through either the antibody-mediated pathway (classical pathway) or the alternative complement pathway. In extravascular tissues, cells that respond to infection or injury include macrophages and mast cells. Macrophages and other immune cells secrete chemokines that recruit leukocytes from the circulation to the site of inflammation. Mast cells release histamine, prostaglandins, and leukotrienes that act as chemokines, increase vascular permeability, and act on the vascular endothelium to increase tissue recruitment of leukocytes. Chemokines can recruit leukocytes or lymphocytes out of the blood stream into tissues and make blood vessels more permeable. Leukocytes are activated by inflammatory signals to express adhesion molecules that cause them to interact with the vascular endothelium, penetrate the endothelial wall and migrate into the extracellular space of tissues. The combined response of immune cells and signaling molecules at the site of inflammation induces swelling, activation of immune cells, and clearance of potential infectious agents. Chronic inflammation can however also lead to tissue damage in conditions such as arthritis, in which anti-inflammatory drugs act on various steps in inflammation to prevent disease. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014816
Subclass_of: Immune Response Regulation Pathway
Synonym: local acute inflammatory response
Tree Number: T4.8.30.36
database_cross_reference: NCI:C39136
database_cross_reference: NCI_BioC:C39136

Monocyte Phagocytosis and Adhesion Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Monocytes are a class of phagocytes involved in non-specific immune defense that develop into macrophages. In plasma, monocytes ingest and destroy bacteria, and can form macrophages when they enter the extracellular space in tissues. In addition to the immune protection that monocytes provide, they may contribute to disease states such as arthritis and heart disease through an aberrant immune response. As with other immune cells, the immune function and differentiation of monocytes rely on communication with other cells through cell surface proteins. Cell surface proteins are involved in both interaction and adhesion with other cells and in transducing signals into the cellular interior. The LFA-1 integrin (Leukocyte function-associated molecule 1) is composed of two subunits, CD11a and CD18 and is involved in monocytes adhesion with ICAM-1 endothelial cells. Mac-1 is composed of the subunits CD11b and CD18 and is induced during inflammation as well. PECAM-1 mediates the migration of monocytes and other immune cells into inflamed tissues through interaction with vascular endothelial cells. CD44 interaction of leukocytes with hyaluronan in the extracellular matrix is induced by inflammation. VLA-4 is another integrin expressed on lymphocytes that plays a role in adhesion through interaction with its adhesion partner on endothelial cells, VCAM-1. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014817
Subclass_of: Immune Response Regulation Pathway
Synonym: Monocyte and its Surface Molecules
Tree Number: T4.8.30.37
database_cross_reference: NCI:C91307
database_cross_reference: NCI_BioC:C91307

Natural Killer Cell-Mediated Cytotoxicity Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stress, such as infection with viruses, bacteria, or parasites or malignant transformation. Although NK cells do not express classical antigen receptors of the immunoglobulin gene family, such as the antibodies produced by B cells or the T cell receptor expressed by T cells, they are equipped with various receptors whose engagement allows them to discriminate between target and nontarget cells. Activating receptors bind ligands on the target cell surface and trigger NK cell activation and target cell lysis. However Inhibitory receptors recognize MHC class I molecules (HLA) and inhibit killing by NK cells by overruling the actions of the activating receptors. This inhibitory signal is lost when the target cells do not express MHC class I and perhaps also in cells infected with virus, which might inhibit MHC class I expression or alter its conformation. The mechanism of NK cell killing is the same as that used by the cytotoxic T cells generated in an adaptive immune response; cytotoxic granules are released onto the surface of the bound target cell, and the effector proteins they contain penetrate the cell membrane and induce programmed cell death.
PMOID: PMO:00014818
Subclass_of: Immune Response Regulation Pathway
Synonym: NK Cell Cytotoxicity
Synonym: Natural killer cell mediated cytotoxicity
Tree Number: T4.8.30.38
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91442
database_cross_reference: NCI_KEGG:C91442

Neutrophil Surface Molecule Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Neutrophils are important phagocytotic leukocytes (white blood cells) that internalize and destroy infectious bacteria by a respiratory burst of reactive oxygen species and by enzymatic digestion. Along with macrophages, neutrophils are crucial phagocytotic cells of the immune system and also contribute to anti-viral defenses, binding to and eliminating free virus or virus-infected cells. The presence of cytoplasmic granules in neutrophils leads to their classification as granulocytes, along with basophils and eosinophils. A lack of neutrophils or their normal function causes a variety of immune disorders and measuring neutrophil cell surface proteins can diagnose abnormal immune function. One such disorder is caused by a lack of normal expression of the adhesion molecules CD11 and CD18 by neutrophils, preventing them from interacting normally with adhesion molecules on endothelial cells and migrating into inflamed sites in tissues. CD11a and CD18 together form the LFA-1 receptor for ICAM-1 on endothelial cells and CD11b/CD18 form Mac-1. Deletion of the CD18 gene in mice produces a significant reduction in leukocyte emigration to sites of inflammation. CD44 is involved in the interaction of neutrophils with endothelial cells and the extracellular matrix during inflammation. The binding of selectins with their carbohydrate ligands also regulates adhesion of neutrophils with endothelial cells, with P- and L-selectins moderating initial interactions and E-selectin moderating subsequent interactions. Genetic disruption of the ability of neutrophils to kill internalized bacteria also impairs normal immune function, along with genetic or acquired lack of the normal number of neutrophils (neutropenia). CD11b binding to a complement component and CD16 binding to IgG Fc contribute to phagocytosis. Inflammatory cytokines activate neutrophils and chemotactic peptides attract them to sites of infection. Inflammatory molecules that activate neutrophils include IL-1, TNF, IL-6, C…
PMOID: PMO:00014819
Subclass_of: Immune Response Regulation Pathway
Synonym: Neutrophil and Its Surface Molecules
Tree Number: T4.8.30.39
database_cross_reference: NCI:C91311
database_cross_reference: NCI_BioC:C91311

NO2-Dependent IL12 Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Macrophages and NK cells help provide innate immunity against infection by intracellular parasites and communicate with each other to regulate this process. When stimulated, macrophages secrete the cytokine IL-12 which is essential for activation of the cytotoxic activity of natural killer (NK) cells. IL-12 stimulates this NK cell response through activation of a JAK/STAT signaling pathway. Binding of IL-12 to its receptor on NK cells causes tyrosine phosphorylation and activation of JAK2 and another JAK kinase, Tyk2. Tyk2 in turn phosphorylates the transcription factor STAT4, which can then translocate to the nucleus to activate genes, including the expression of interferon-gamma. IFN-gamma and IL-12 induce the differentiation of TH1 helper T cells that activate macrophages through interferon-gamma. A key modulator of NK cell activation by IL-12 is nitric oxide, NO, produced from arginine by the inducible nitric oxide synthase NOS2. Inactivation of the NOS2 gene in mice impairs the initial innate response to infection, including the activation of NK cells. This phenotype is similar to that of mice lacking interferon-gamma or IL-12 and a similar effect can be produced by inhibiting NOS2 with L-N6-iminoethyl-lysine (L-NIL) during infection, blocking the activation of NK cells by IL-12. NO production does not affect the activation of JAK2 by IL-12, but is required for Tyk2 activity, the downstream activation of STAT-4 and the production of interferon-gamma by NK cells. The role of NO in Tyk2 activation is not yet known, but does not seem to involve changing the phosphorylation status of Tyk2. Curiously, activation of T cells by IL-12 does not appear to involve NO production, indicating a distinct mechanism is involved in NK cells. NO also plays a role as a feedback inhibitor of IL-12 production by macrophages, helping to prevent over-activation of the Th1 cells by IL-12. NO appears to make an important contribution to the early innate response to infections before spe…
PMOID: PMO:00014820
Subclass_of: Immune Response Regulation Pathway
Synonym: NO2-dependent IL 12 Pathway in NK cells
Tree Number: T4.8.30.40
database_cross_reference: NCI:C39168
database_cross_reference: NCI_BioC:C39168

Ras-Independent Cell-Mediated Cytotoxicity Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK cell-mediated cytotoxicity is activated by glycoproteins on the cell surface (activating receptors) and inhibited by MHC-1 with self-peptide bound. The MHC-1 inhibitory signal through Ig-family or lectin receptors prevents NK cells from killing normal cells. Abnormal MHC-1 expression in infected or tumor cells results in the release of perforin, the lysis of the abnormal cell and the release of cytokines that stimulate the immune response. MAP kinase inhibitors, but not ras inhibitors, are able to block NK cell cytotoxicity, indicating that the pathway can function by a ras-independent manner that involves the MAP kinase pathway. This pathway includes phosphoinositide-3-kinase (PI3K) as a key component, followed by Rac1 and the exchange factor Vav. The tyrosine kinase SYK and LAT may provide an additional pathway for activation of MAP kinases leading to NK cell activation, and also Pyk-2 activation by integrins. The protein tyrosine phosphatase SHP-1 appears to mediate the cytotoxicity inhibitory signal that blocks lysis of normal cells. The balance of these positive and negative signaling pathways regulates the role of NK cells in the immune response. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014821
Subclass_of: Immune Response Regulation Pathway
Synonym: Ras-Independent pathway in NK cell-mediated cytotoxicity
Tree Number: T4.8.30.41
database_cross_reference: NCI:C39165
database_cross_reference: NCI_BioC:C39165

T Cell Receptor and CD3 Complex Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The T cell receptor is a cell-surface receptor that recognizes specific antigen to stimulate the T cell response to that antigen. The T cell receptor complex of transmembrane proteins includes the T cell receptor that recognizes antigen and a set of proteins called CD3 involved in signal transduction. CD3 associated with the T cell receptor includes six polypeptides arranged in three dimers that recruit and activate protein kinases to signal the activation of T cell receptor by bound antigen through recruitment and activation of protein kinases (see T Cell Receptor Signaling Pathway). T cell receptors only recognize antigen on the surface of other cells, not antigen in solution, by requiring antigen to be bound to MHC proteins on the surface of other cells to be recognized. Cytotoxic T cells recognize antigen bound to MHC I on the surface of other cells and helper T cells recognize antigen bound to MHC II on antigen-presenting cells. CD4 (helper T cells) and CD8 (cytotoxic T cells) are cofactors in MHC recognition. Recombination in immature T cells of the genes for the alpha and beta T cell receptor subunits creates a huge variety of variable regions involved in antigen recognition resulting in many antigen specificities in the population of immature T cells. Some T cells called gamma/delta cells express T cell receptor composed of gamma and delta subunits rather than alpha/beta subunits. When the T cell receptor on a cell interacts with antigen in the proper context, that cell is stimulated to become activated and proliferate, in a process known as clonal selection. The recombination of T cell receptor genes and clonal selection of cells that bind specific antigen is very similar to the B cell process that creates immunoglobulins and clonal selection of B cells that bind antigen. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014822
Subclass_of: Immune Response Regulation Pathway
Synonym: T Cell Receptor and CD3 Complex
Synonym: T Cell Receptor and CD3 Complex Pathway
Tree Number: T4.8.30.42
database_cross_reference: NCI:C91304
database_cross_reference: NCI_BioC:C91304

T Cell Receptor Signaling Pathway BioCarta
type: Class
subclass of: Immune Response Regulation Pathway
definition: The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell's transcriptional machinery upon engagement of the receptor. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014823
Subclass_of: Immune Response Regulation Pathway
Synonym: T Cell Receptor Signaling Pathway
Synonym: T cell receptor signaling pathway
Synonym: T lymphocyte receptor signaling pathway
Synonym: T lymphocyte receptor signalling pathway
Synonym: T-cell receptor signaling pathway
Synonym: T-cell receptor signalling pathway
Synonym: T-lymphocyte receptor signaling pathway
Synonym: T-lymphocyte receptor signalling pathway
Synonym: TCR signaling pathway
Tree Number: T4.8.30.43
database_cross_reference: GO:GO:0050852
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39246
database_cross_reference: NCI_BioC:C39246

T Cell Receptor Signaling Pathway KEGG
type: Class
subclass of: Immune Response Regulation Pathway
definition: Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.
PMOID: PMO:00014824
Subclass_of: Immune Response Regulation Pathway
Synonym: T cell receptor signaling pathway
Synonym: TCR Signaling Pathway
Tree Number: T4.8.30.44
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91450
database_cross_reference: NCI_KEGG:C91450

T Helper Cell Surface Molecule Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: T helper cells play an essential role coordinating the activities of other parts of the immune system, including B cells, cytotoxic T cells, macrophages and other cells. The crucial nature of helper T cells in the normal immune response is demonstrated by the severe immune deficiency associated with the HIV-induced helper T cell depletion. To communicate with other cells, helper T cells express a range of cell surface molecules, a few of which are illustrated in this figure. Like all T cells, helper T cells express T cell receptors complexed with the CD3 proteins that are responsible for the recognition and response of the cell to specific antigens (see T Cell Receptor Signaling Pathway). CD4 is commonly used as a marker for helper T cells, in contrast to cytotoxic T cells, which express CD8. CD4 is used by HIV to gain cell entry, as well as the CCR5 chemokine receptor. Thy1 provides a more general cell surface antigen used to identify both T helper and cytotoxic T cells. CD28 provides a costimulatory signal in association with the activation of the T cell receptor complex by an antigen presenting cell that is required for the T cell to become activated (see The Co-Stimulatory Signal During T-cell Activation pathway). Adhesion molecules on the surface of T cells assist in their interaction with other cells. LFA-1 binds to its ligand ICAM-1 in a variety of cells and T cells themselves also express ICAM-1. The CD45 protein tyrosine phosphatase dephosphorylates factors in the pathways involved in B cells and T cells activation. Although CD45 is required for T cell receptor activation, exclusion of CD45 from the local membrane region near the T cell receptor appears important for efficient T cell activation. Helper T cells can be subdivided further into Th1 and Th2 cells, distinguished by their response to different antigens, differing cytokine expression and expression of different chemokine receptors (see Selective expression of chemokine receptors during T-cell polar…
PMOID: PMO:00014825
Subclass_of: Immune Response Regulation Pathway
Synonym: T Helper Cell Surface Molecules
Tree Number: T4.8.30.45
database_cross_reference: NCI:C91306
database_cross_reference: NCI_BioC:C91306

T-Cell Activation Co-Stimulatory Signaling Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: For a T cell to be activated by a specific antigen, the T cell receptor must recognize complexes of MHC-1 with the antigen on the surface of an antigen-presenting cell. T cells and the T cell receptor complex do not respond to antigen in solution, but even for the specific antigen they only respond to antigen-MHC-1 complexes on the cell surface. This interaction is necessary for T cell activation, but it is not sufficient. T cell activation also requires a co-stimulatory signal involving interaction of CD28 on the T cell with CD80 or CD86 (B7 family genes) on the antigen-presenting cell. CD28 activates a signal transduction pathway acting through PI-3K, Lck and Grb-2/ITK to provide its co-stimulatory signal for T cell activation. Another means to control T cell activation is by expressing factors that down-regulate T cell activation. Signaling by activated T cell receptors induces expression of CTLA-4, a receptor that opposes T cell activation. CTLA-4 has a higher affinity than CD28 for B7 proteins, terminating T cell activation. ICOS is a protein related to CD28 that is only expressed on activated T cells, and that provides another important co-stimulatory signal. The requirement for co-stimulatory signals provides additional control mechanisms that prevent inappropriate and hazardous T cell activation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014826
Subclass_of: Immune Response Regulation Pathway
Synonym: The Co-Stimulatory Signal During T-cell Activation
Tree Number: T4.8.30.46
database_cross_reference: NCI:C39041
database_cross_reference: NCI_BioC:C39041

T-Cell Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Regulation of T cell activation is a crucial component of balanced functioning of the immune system. If the T cell response is too great and activation of self-responsive cells or unstimulated cells is not suppressed, then autoimmune disorders or tissue injury can result. Unstimulated T cells are maintained in a quiescent state and the activity of self-reactive T cells is maintained in an anergic state in which IL-2 expression is repressed. IL-2 is a cytokine with a key role in the activation and proliferation of T cells. The maintenance of T cells in the anergic or unstimulated state may not involve just an absence of activation, but an active repression of IL-2 expression, T cell proliferation, and activation. TGF beta may play a role in suppressing T cell activation. Tob is a member of a family of genes with anti-proliferative properties that represses T cell activation. Tob expression is highest in unstimulated and anergic T cells, and is reduced in activated T cells. Tob interacts with the TGF activated transcription factors SMAD2 and SMAD4, increasing their binding to the IL-2 promoter, and helping to repress IL-2 expression. This role of Tob suggests that interference in Tob's function may lead to autoimmune disease. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014827
Subclass_of: Immune Response Regulation Pathway
Synonym: Role of Tob in T-cell activation
Tree Number: T4.8.30.47
database_cross_reference: NCI:C39256
database_cross_reference: NCI_BioC:C39256

T-Cell Antiapoptosis Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014828
Subclass_of: Immune Response Regulation Pathway
Synonym: Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
Tree Number: T4.8.30.48
database_cross_reference: NCI:C39266
database_cross_reference: NCI_BioC:C39266

T-Cell Polarization Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: Chemokine receptors expressed by T helper cells help recruit cells to specific locations based on their chemoattractant ligands. The polarization of T cells into Th1 and Th2 cells is associated with their expression of different subsets of chemokine receptors. Naive CD4 positive cells that have not been exposed to antigen express CXCR4 and CCR7. The most abundant chemokine receptors on Th1 cells involved in the cellular immune response to microbial agents include CXCR3, CCR1, CCR2 and CCR5, while Th2 cells express CCR2, CCR3 and CCR5. An additional class of T cells termed semi-naive cells may be induced by TGF-beta to express yet another class of chemokine receptors, CCR4 and CCR7. Although the expression of chemokine receptors in different cells is preferred in these cases, it is not absolute or exclusive, and there is overlap in expression between Th1 and Th2 cells. Although CCR7 positive cells have been reported to lack effector action, not be polarized, and to home only to lymphoid tissues, other studies have found CCR7 positive Th1 and Th2 cells and have identified CCR7 positive cells in non-lymphoid tissues. CCR4 appears associated with homing of lymphocytes to the skin, and CCR9 is associated with homing to the small intestine, while other chemokines like CXCR3 and CCR5 are associated with homing toward inflamed tissues more broadly. The expression of different chemokine receptors by subsets of T helper cells plays an important role in the migration and homing of these cells in tissues, and targeting of the immune response to specific cells. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014829
Subclass_of: Immune Response Regulation Pathway
Synonym: Selective expression of chemokine receptors during T-cell polarization
Tree Number: T4.8.30.49
database_cross_reference: NCI:C39166
database_cross_reference: NCI_BioC:C39166

T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
type: Class
subclass of: Immune Response Regulation Pathway
PMOID: PMO:00014830
Subclass_of: Immune Response Regulation Pathway
Synonym: TCR signaling in naïve CD4+ T cells
Tree Number: T4.8.30.50
database_cross_reference: NCI:C91553
database_cross_reference: NCI_PID:C91553

Calcium Signaling in the CD4+ TCR Pathway
type: Class
subclass of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
PMOID: PMO:00014831
Subclass_of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
Synonym: Calcium signaling in the CD4+ TCR pathway
Tree Number: T4.8.30.50.1
database_cross_reference: NCI:C91557
database_cross_reference: NCI_PID:C91557

JNK Signaling in the CD4+ TCR Pathway
type: Class
subclass of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
PMOID: PMO:00014832
Subclass_of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
Synonym: JNK signaling in the CD4+ TCR pathway
Tree Number: T4.8.30.50.2
database_cross_reference: NCI:C91629
database_cross_reference: NCI_PID:C91629

Ras Signaling in the CD4+ TCR Pathway
type: Class
subclass of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
PMOID: PMO:00014833
Subclass_of: T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells
Synonym: Ras signaling in the CD4+ TCR pathway
Tree Number: T4.8.30.50.3
database_cross_reference: NCI:C91657
database_cross_reference: NCI_PID:C91657

T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells
type: Class
subclass of: Immune Response Regulation Pathway
PMOID: PMO:00014834
Subclass_of: Immune Response Regulation Pathway
Synonym: TCR signaling in naïve CD8+ T cells
Tree Number: T4.8.30.51
database_cross_reference: NCI:C91554
database_cross_reference: NCI_PID:C91554

Downstream Signaling Pathway in Naive CD8+ T Cells
type: Class
subclass of: T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells
PMOID: PMO:00014835
Subclass_of: T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells
Synonym: Downstream signaling in naïve CD8+ T cells
Tree Number: T4.8.30.51.1
database_cross_reference: NCI:C91573
database_cross_reference: NCI_PID:C91573

TCR Activation Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: T cell activation is initiated by recognition of antigen by the T cell receptor (TCR) in the context of Class II MHC on an antigen-presenting cell. The T cell receptor contains multiple subunits and interacts with several factors to transduce antigen-stimulated T cell activation. One of the key steps that initiates receptor activation is the tyrosine phosphorylation of TCR subunits by the src family protein kinases Lck and Fyn. T cell receptor phosphorylated by Lck and Fyn recruits the ZAP-70 protein kinase to the receptor complex, which becomes activated and stimulates downstream pathways like the Map kinase cascade. The CD45 protein tyrosine phosphatase activates Lck and Fyn by dephosphorylating these proteins and is required for TCR activation. Association of the CD4 coreceptor with Lck may also be involved in Lck activation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014836
Subclass_of: Immune Response Regulation Pathway
Synonym: Lck and Fyn tyrosine kinases in initiation of TCR Activation
Tree Number: T4.8.30.52
database_cross_reference: NCI:C39245
database_cross_reference: NCI_BioC:C39245

Toll-Like Receptor Pathway
type: Class
subclass of: Immune Response Regulation Pathway
definition: The innate immune response responds in a general manner to factors present in invading pathogens. Bacterial factors such as lipopolysaccharides (LPS, endotoxin), bacterial lipoproteins, peptidoglycans, and also CpG nucleic acids activate innate immunity as well as stimulating the antigen-specific immune response and triggering the inflammatory response. Members of the toll-like receptor (TLR) gene family convey signals stimulated by these factors, activating signal transduction pathways that result in transcriptional regulation and stimulate immune function. TLR2 is activated by bacterial lipoproteins, TLR4 is activated by LPS, and TLR9 is activated by CpG DNA; peptidoglycan recognition protein (PGRP) is activated by peptidoglycan (PGN). The downstream signaling pathways used by these receptors are similar to that used by the IL-1 receptor, activating the IL-1 receptor associated kinase (IRAK) through the MyD88 adaptor protein, and signaling through TRAF-6 and protein kinase cascades to activate NF-kB and Jun. NF-kB and c-Jun activate transcription of genes such as the proinflammatory cytokines IL-1 and IL-12. Several reports have suggested that the functional outcomes of signaling via TLR2, TLR4, and PGRP are not equivalent. For example, while the LPS-induced, p38-dependent response was dependent upon PU.1 binding, the PGN-induced, p38 response was not. The intracellular receptor for PGN, PGRP, is conserved from insects to mammals. In insects, PGRP activates prophenoloxidase cascade, a part of the insect antimicrobial defense system. Because mammals do not have the prophenoloxidase cascade, its function in mammals is unknown. However, it was suggested that an identical protein Tag7 was a tumor necrosis factor-like (TNF-like) cytokine. PGRP/Tag7 possesses cytotoxicity and triggers intranucleosomal DNA fragmentation in target cells in the same way as many known members of the TNF family. Fragmentation of DNA is one of the characteristics of apoptosis. The possibility…
PMOID: PMO:00014837
Subclass_of: Immune Response Regulation Pathway
Tree Number: T4.8.30.53
database_cross_reference: NCI:C39257
database_cross_reference: NCI_BioC:C39257

Inhibition of Matrix Metalloproteinases Pathway
type: Class
subclass of: Regulatory Pathway
definition: Cellular transformation is accompanied by many cellular changes, including uncontrolled proliferation, loss of the differentiated cell morphology, and invasion of the extracellular matrix. Degradation of the extracellular matrix is a key component of tumor cell invasion into surrounding tissues. Matrix metalloproteinases (MMPs) are a class of proteases secreted by tumor cells, degrading the proteins of the extracellular matrix and allowing metastasis. Drug inhibitors of MMPs are one strategy to control cancer and block metastasis. In searching for genes that reverse the rounded morphology of transformed cells in culture, RECK was identified (reversion-inducing, cysteine-rich protein with Kazal motifs). RECK is a membrane-anchored inhibitor of matrix metalloproteinases, inhibiting MMP-2, MMP-9, and MT1-MMP. The processing of MMPs to their active form occurs at the plasma membrane, making the localization of RECK at the membrane a key to its potent activity as an inhibitor of MMP activity. Soluble secreted MMP inhibitors have also been identified, TIMPs, which appear to be less active at inhibiting MMPs and even perhaps to be essential for MMP maturation. The inhibition of MMPs by RECK inhibits invasion of tissues, metastasis, and tumor angiogenesis, and is essential for normal development. In addition to playing a role in tissue invasion in cancer, the activity of MMPs in angiogenesis, inflammation, and development is regulated by inhibitors such as RECK and TIMPs. RECK expression is inhibited by ras, suggesting one component by which ras induces transformation. High levels of RECK expression in tumors is correlated with cancer patient survival and overexpression of RECK may offer a therapeutic strategy for the control of cancer. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014838
Subclass_of: Regulatory Pathway
Synonym: Inhibition of Matrix Metalloproteinases
Tree Number: T4.8.31
database_cross_reference: NCI:C39219
database_cross_reference: NCI_BioC:C39219

Integrin Angiogenesis Pathway
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014839
Subclass_of: Regulatory Pathway
Synonym: Integrins in angiogenesis
Tree Number: T4.8.32
database_cross_reference: NCI:C91627
database_cross_reference: NCI_PID:C91627

Osteopontin-Mediated Signaling Pathway
type: Class
subclass of: Integrin Angiogenesis Pathway
PMOID: PMO:00014840
Subclass_of: Integrin Angiogenesis Pathway
Synonym: Osteopontin-mediated events
Tree Number: T4.8.32.1
database_cross_reference: NCI:C91641
database_cross_reference: NCI_PID:C91641

MAP Kinase Downregulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk networks. A closely studied Map kinase cascade originates with tyrosine kinase activation, and activation of Ras. Ras activates Raf, Raf activates the Map kinase kinases Mek1 and Mek2 and these kinases activate downstream Map kinases like Erk1 and Erk2. Erk1 and Erk2 in turn activate transgenes like p35 through the Map kinase activated transcription factor EGR-1. Mek1 plays a central role in many different Map kinase pathways. Factors that activate Mek1 include growth factors like NGF, cytokines, chemokines, and phorbol ester, resulting in cellular proliferation and survival. Mek1 activation may also play a role in differentiation in neuronal tissues. In cultured neuronal PC-12 cells, NGF induces neurite outgrowth via Mek1 and the map kinase pathway. Constitutive activation of Mek1 can transform cells and may play a role in cancer. The crucial role of Mek1 in a variety of pathways including cellular transformation suggests that the cell must tightly regulate its activity. Cdk5 is a kinase that regulates the activity of Mek1. Although Cdk5 is a member of the cyclin-dependent kinase gene family, the activity of Cdk5 does not appear to be regulated by cyclins, but is activated by association with p35. Cdk5 does not act as a checkpoint kinase to regulate cell cycle progression, but acts as a regulatory kinase involved in other post-mitotic processes such as neuronal activity such as neuronal migration during development and neurite outgrowth. Mice lacking Cdk5 exhibit defects in neuronal development. One target of Cdk5 is Mek1. Phosphorylation of Mek1 by Cdk5 represses Mek1 activity and blocks downstream cellular responses. The activation of p35 by Map kinase pathways followed by deactivation of Map kinase signaling by the Cdk5/p35 complex completes the loop of a feedback circuit to terminate Map kinase signaling. (This definit…
PMOID: PMO:00014841
Subclass_of: Regulatory Pathway
Synonym: Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
Tree Number: T4.8.33
database_cross_reference: NCI:C39022
database_cross_reference: NCI_BioC:C39022

Map Kinase Inactivation of SMRT Corepressor Pathway
type: Class
subclass of: Regulatory Pathway
definition: Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is represented in this pathway. The EGF receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by either pathway causes SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014842
Subclass_of: Regulatory Pathway
Synonym: Map Kinase Inactivation of SMRT Corepressor
Tree Number: T4.8.34
database_cross_reference: NCI:C39059
database_cross_reference: NCI_BioC:C39059

MAP Kinase Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and mediate a number of physiological and pathological changes in cell function. There are three major subgroups in the MAPK family: ERK, p38, and JNK/SAPK. ERK is activated mainly by mitogenic stimuli, whereas p38 and JNK/SAPK are activated mainly by stress stimuli or inflammatory cytokines. MAP kinases are part of a three-tiered phosphorylation cascade and MAP kinase phosphorylation on a threonine and tyrosine residue located within the activation loop of kinase subdomain VIII results in activation. However, this process is reversible even in the continued presence of activating stimuli, indicating that protein phosphatases provide an important mechanism for MAP kinase control. Dual specificity phosphatases (DSPs) from the tyrosine phosphatase (PTP) gene superfamily are selective for dephosphorylating the critical phosphothreonine and phosphotyrosine residues within MAP kinases. Ten members of dual specificity phosphatases specifically acting on MAPKs, termed MAPK phosphatases (MKPs), have been reported. They share sequence homology and are highly specific for MAPKs but differ in the substrate specificity, tissue distribution, subcellular localization, and inducibility by extracellular stimuli. MKPs have been shown to play important roles in regulating the function of the MAPK family. DSP gene expression is induced strongly by various growth factors and/or cellular stresses. Expression of some gene family members, including CL100/MKP-1, hVH-2/MKP-2, and PAC1, is dependent at least in part on MAP kinase activation providing negative feedback for the inducing MAP kinase or for regulatory cross talk between parallel MAP kinase pathways. DSPs are localized to different subcellular compartments and certain family members appear highly selective for inactivating distinct MAP kinase isoforms. This enzymatic specificity is due to catalytic activati…
PMOID: PMO:00014843
Subclass_of: Regulatory Pathway
Synonym: Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases
Tree Number: T4.8.35
database_cross_reference: NCI:C39053
database_cross_reference: NCI_BioC:C39053

Mitotic Spindle Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes are not just passengers along for a ride with the spindle, but active participants in the nucleation and stabilization of spindle microtubules in their near vicinity. The ras-like GTPase Ran that regulates nucleocytoplasmic transport through the nuclear pore complex (NPC) during interphase also regulates the formation of the mitotic spindle. Ran plays a similar role in each of these processes, regulating downstream signaling pathways in a differential manner based on whether GDP or GTP is bound. Like other GTPases, the inherent GTPase activity of Ran is regulated by GTPase activating proteins (GAPs) and by exchange factors. An exchange factor that stimulates nucleotide exchange by the Ran GTPase is RCC1, which binds to chromatin in both interphase and mitosis. While RCC1 helps RAN drive transport between the nucleus and cytoplasm during interphase, the localization of RCC1 on chromatin during mitosis localizes Ran-GTP near chromosomes, localizing microtubule formation in these regions. Ran-BP1 and Ran-GAP1 stimulate GTP hydrolysis by Ran, converting it back to Ran-GDP further away from chromosomes. Aster promoting activities (APA) and the importin-alpha and importin-beta proteins involved with Ran in nucleocytoplasmic transport are also involved in mitotic spindle formation. Aster promoting activities stabilize microtubules during spindle formation, but binding of importins to APA neutralizes their activity in forming microtubules. The importins bind to APA when far from the chromosomes, where Ran-GDP predominates, but Ran-GTP near chromosomes causes importins to release APA factors including Tpx2 and NuMa, allowing them to stimulate microtubule formation. Tpx2 interacts with the microtubule motor protein Xklp2 and also activates the Aurora A mitotic kinase, required for spindle formation. In addition to regulating spi…
PMOID: PMO:00014844
Subclass_of: Regulatory Pathway
Synonym: Role of Ran in mitotic spindle regulation
Tree Number: T4.8.36
database_cross_reference: NCI:C39213
database_cross_reference: NCI_BioC:C39213

Obesity and Thermogenesis Pathway
type: Class
subclass of: Regulatory Pathway
definition: Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPAR-gamma is a member of this gene family that is activated by fatty acids and thiazolidinedione drugs that plays a role in insulin sensitivity and adipogenesis. Like PPAR-alpha and other members of this gene family, PPAR-gamma activates transcription in concert with coactivators including Src-1 and Tif2. Although these coactivators act for multiple members of this gene family, coactivators may have specific functions in some settings. Deletion of the Src-1 gene or Tif2 gene in mice reduced the response to steroid hormones and development dependent on these hormones. Some PPAR-gamma ligands induce the specific recruitment of coactivators, and might evoke different functional responses based on the interactions they favor. The natural ligand 15-deoxy prostaglandin J2 stimulated PPAR-gamma interaction with SRC-1, TIF2, TRAP220, and p300, while the synthetic PPAR-gamma ligand troglitazone, an antidiabetic thiazolidinedione drug, did not promote these interactions, indicating that other distinct coactivators may mediate the response to PPAR-gamma when it binds this ligand. In normal rodents, a high-fat diet leads to high levels and free fatty acids and PPAR-gamma activation in white adipose tissue, stimulating fat uptake, adipogenesis and obesity. PPAR-gamma activation in brown adipose tissue depends mainly on Src-1 as a coactivator and Src-1 is essential for PGC-1 alpha to act as a coactivator to stimulate thermogenesis. Regulation of energy use by PGC-1 in other tissues such as muscle may contribute to weight loss associated with cancer and increased metabolism induced by exercise. High-fat feeding and high plasma free fatty acids reduce thermogenesis in brown fat due to the greater requirement of PPAR-gamma for Src-1 than Tif2 for activation in these cells. In white adipose cells, Tif2 predominates as the PPAR-gamma coactivator, stimulating fat …
PMOID: PMO:00014845
Subclass_of: Regulatory Pathway
Synonym: Role of PPAR-gamma Coactivators in Obesity and Thermogenesis
Tree Number: T4.8.37
database_cross_reference: NCI:C39198
database_cross_reference: NCI_BioC:C39198

Oocyte Meiosis Pathway
type: Class
subclass of: Regulatory Pathway
definition: During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle.
PMOID: PMO:00014846
Subclass_of: Regulatory Pathway
Synonym: Oocyte meiosis
Tree Number: T4.8.38
database_cross_reference: NCI:C91472
database_cross_reference: NCI_KEGG:C91472

p53 Pathway for Transcriptional Regulation
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014847
Subclass_of: Regulatory Pathway
Synonym: p53 pathway
Tree Number: T4.8.39
database_cross_reference: NCI:C91571
database_cross_reference: NCI_PID:C91571

p53 Effector Pathway
type: Class
subclass of: p53 Pathway for Transcriptional Regulation
PMOID: PMO:00014848
Subclass_of: p53 Pathway for Transcriptional Regulation
Synonym: Direct p53 effectors
Tree Number: T4.8.39.1
database_cross_reference: NCI:C91572
database_cross_reference: NCI_PID:C91572

PGC1a Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for energy metabolism and energy homeostasis. Inappropriate increases in PGC-1a activity have been linked to a number of pathological conditions including heart failure and diabetes. PGC-1a is highly expressed in metabolically active tissues including brown fat, skeletal muscle and heart. PGC-1a has been implicated in mitochondrial biogenesis in the heart and increased mitochondrial respiration in brown fat. PGC-1a is a coactivator for many factors including, CBP, Scr-1, PPARa, glucocorticoid receptor, thyroid hormone receptor, several orphan receptors, and MEF2. This pathway illustrates two of the cofactor regulatory factors, MEF2 and PPARa, and an example orphan receptor feedback inhibition loop. Glut4 is used as an example of the downstream elements leading to changes in metabolism. Ichida et al discovered the ERRa repression of PGC-1a. Their results suggest a novel mechanism of transcriptional control wherein ERR-a can function as a specific molecular repressor of PGC-1a. This suggests that other co-activators might also have specific repressors, adding another layer of combinatorial complexity in transcriptional regulation. Czubryt et al identified PGC-1a as a key target of the MEF2/HDAC regulatory pathway and demonstrated this pathway's importance in maintenance of cardiac mitochondrial function. The linking of MEF2/HDAC provides a potential explanation for the increase in mitochondrial number observed in response to CaMK signaling. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014849
Subclass_of: Regulatory Pathway
Synonym: Regulation of PGC-1a
Tree Number: T4.8.40
database_cross_reference: NCI:C39188
database_cross_reference: NCI_BioC:C39188

Phosphoinositide Pathway
type: Class
subclass of: Regulatory Pathway
definition: Nine currently identified phosphoinositide 3-kinases (PI 3-K) constitute a subfamily of lipid kinases that catalyze the addition of a phosphate molecule on the 3-position of the inositol ring of phosphoinositides. Phosphatidylinositol (PtdIns), the precursor of all phosphoinositides (PI), constitutes less than 10% of the total lipid in eukaryotic cell membranes. Approximately 5% of cellular PI is phosphorylated at the 4-position (PtdIns-4-P), and another 5% is phosphorylated at both the 4- and 5-positions (PtdIns-4, 5-P2). However, less than 0.25% of the total inositol-containing lipids are phosphorylated at the 3-position, consistent with the idea that these lipids exert specific regulatory functions inside the cell, as opposed to a structural function. Here we have chosen to highlight a group of the phosphoinositide targets of the PI3-Ks and their downstream targets. The downstream effects of these PI-3 targets are indicated, illustrating the important role the PI3Ks have in cell function and survival. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014850
Subclass_of: Regulatory Pathway
Synonym: Phosphoinositides and their downstream targets
Tree Number: T4.8.41
database_cross_reference: NCI:C39204
database_cross_reference: NCI_BioC:C39204

Pitx2 Transcription Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordinated transcriptional control of proliferation in specific developmental cell types is crucial in multiple developmental settings. One of a family of three bicoid-related transcription factors, Pitx2 acts downstream of the extracellular signaling protein Wnt to drive proliferation of cells with specific developmental fates, including cells in the pituitary, cardiac outflow region, and muscle. Wnt binds to Frizzled, a G-protein coupled receptor, activating homologs of the Drosophila Disheveled protein. Activation of Frizzled and Disheveled inhibits the kinase GSK-3 beta, part of a protein complex in the absence of Wnt signaling, causing beta-catenin protein to accumulate in the cytoplasm. Beta-catenin is known to alter the function of transcription factors like TCF/Lef. One result of Wnt signaling is activation of the transcription factor Lef by beta-catenin, inducing Pitx2 expression. Wnt activation also changes Pitx2 from a repressor to an activator by causing transcriptional corepressors like histone deacetylase 1 (HDAC1) bound to Pitx2 to be exchanged for coactivators. With coactivators bound, Pitx2 activates transcription of genes that regulate the cell cycle, such as Cyclin D2. Different coactivators are recruited by Pitx2 and other transcription factors like Myc to the Cyclin D2 promoter, with CBP/p300 recruited first, followed by NLI/Ldb/CLIM, Tip60/TRRAP, and PBP coactivators. Many of these coactivators help to alter histone acetylation and chromatin structure as part of transcriptional activation. The activation of cell cycle genes by Pitx2 ultimately stimulates the proliferation of specific cell types with the confluence of tissue-specific gene expression, growth factor signaling and coactivator recruitment. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014851
Subclass_of: Regulatory Pathway
Synonym: Multi-step Regulation of Transcription by Pitx2
Tree Number: T4.8.42
database_cross_reference: NCI:C39189
database_cross_reference: NCI_BioC:C39189

PML Transcription Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptosis and are characterized by the presence of the protein PML. The activities of PML as a tumor suppressor and apoptosis inducing factor are exerted through the numerous proteins it interacts with in the PML-nuclear bodies including the tumor suppressor p53. DNA damage-induced activation of p53-dependent apoptosis requires PML. PML acts as a coactivator for p53 and increases acetylation of p53 by the transcriptional coactivator CBP. This acetylation of p53 is reversed by the deacetylase SirT1, the human homolog of the yeast gene Sir2, and this deacetylation opposes the transcriptional activation of p53. The tumor suppressor Rb also interacts with the PML nuclear body, increasing transcriptional repression of genes involved in cell cycle progression, suggesting that PML may affect cellular transformation through more than one mechanism. PML interacts directly with Ubc9, which modifies PML through the attachment of the ubiquitin-like peptide Sumo-1. Sumo-1 modification of PML is not necessary for the nuclear bodies to form, but may affect the recruitment of proteins that interact with PML. PML is involved in non-p53 mediated apoptotic pathways, such as DAXX-mediated apoptosis induced by Fas and TNF and regulates the transcriptional repressor activity of Daxx. The sequestration of Daxx by the PML nuclear bodies relieves the repression of other transcription factors like Pax3 by Daxx. Tumor suppression by PML may in general involve the formation of specific regulatory transcription complexes, including those with DAXX, p53 and CBP. Factors that affect the assembly of PML into the PML nuclear bodies affect the proliferation and transformation of cells. Viral early proteins can interact with PML to disrupt the nuclear bodies, allowing increased proliferation of cells and reduced apoptosis, good conditions for DNA virus infecti…
PMOID: PMO:00014852
Subclass_of: Regulatory Pathway
Synonym: Regulation of transcriptional activity by PML
Tree Number: T4.8.43
database_cross_reference: NCI:C39196
database_cross_reference: NCI_BioC:C39196

PPAR-alpha Gene Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: The most recognized mechanism by which peroxisome proliferators regulate gene expression is through a PPAR/RXR heterodimeric complex binding to a peroxisome proliferator-response element (PPRE) (classical mechanism). However, there is the possibility of several variations on this theme: 1) the peroxisome proliferator interacts with PPAR that preexists as a DNA complex with associated corepressors proteins. The interaction with ligand causes release of the corepressor and association with a coactivator, resulting in the classical mechanism. 2) the peroxisome proliferator interacts with PPAR as a soluble member of the nucleus. The binding of ligand results in RXR heterodimerization, DNA binding and coactivator recruitment. 3) in this scenario, PPAR exists in the cytosol, perhaps complexed to heat shock protein 90 and/or other chaperones. Binding of peroxisome proliferator causes a conformational change and translocation into the nucleus. Scenarios 4 and 5 require regulation of gene expression via non-classical mechanisms: 4) PPAR is capable of interacting with, and forming DNA binding heterodimers with, several nuclear receptors including the thyroid hormone receptor. The binding site for this non-RXR heterodimer need not be the classic DR-1 motif found in the PPRE. 5) PPAR may participate in the regulation of gene expression without binding to DNA. By association with transcription factors such as c-jun or p65, PPAR diminishes the ability of AP1 or NFB to bind to their cognate DNA sequences, respectively. Also shown in this scheme are two means to modify the peroxisome proliferator response. Most importantly, growth factor signaling has a pronounced affect on PPAR via post-translational modification. PPAR is a phosphoprotein and its activity is affected by insulin. Several kinase pathways affect PPARa's activity, although the specific kinases and phosphorylation sites have not been conclusively determined. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014853
Subclass_of: Regulatory Pathway
Synonym: Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
Synonym: PPARA Gene Regulation Pathway
Tree Number: T4.8.44
database_cross_reference: NCI:C39197
database_cross_reference: NCI_BioC:C39197

Protein Activation Pathway
type: Class
subclass of: Regulatory Pathway
definition: A sequence of biological or biochemical events that are involved in the manifestation of the activity of a protein.
PMOID: PMO:00014854
Subclass_of: Regulatory Pathway
Synonym: Positive Regulation of Protein Activity Pathway
Tree Number: T4.8.45
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C40420

Extrinsic Prothrombin Activation Pathway
type: Class
subclass of: Protein Activation Pathway
definition: Blood coagulation takes place in 3 essential phases. The first phase is the activation of a prothrombin activator complex. The second phase is the activation of prothrombin. The third stage is clot formation as a result of fibrinogen cleavage by activated thrombin. The prothrombin activation complex is formed by two pathways each of which results in a different form of the prothrombin activator. The extrinsic mechanism of prothrombin activator formation begins with trauma to vascular walls or extravascular tissues. The damaged tissue releases tissue thromboplastin also known as tissue factor (TF). The formation of a clot by this mechanism usually takes as little as 15 seconds. This cascade is initiated by the activation of factor X by TF and factor VII. Activated factor X combined with factor V, factor VII and TF constitutes the prothrombin activator. Calcium (Ca++) is required for each of these steps. The prothrombin activator in the extrinsic pathway is very similar to the activator in the intrinsic pathway. Antithrombin III inhibits the activity of thrombin and also the step leading to the activation of factor X. Antithrombin III is a hundred to a thousand times more effective when bound by heparin. Protein C is activated by thrombin and with the Protein S cofactor provides a strong negative feedback in this phase of clot formation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014855
Subclass_of: Protein Activation Pathway
Tree Number: T4.8.45.1
database_cross_reference: NCI:C39076
database_cross_reference: NCI_BioC:C39076

Intrinsic Prothrombin Activation Pathway
type: Class
subclass of: Protein Activation Pathway
definition: Blood coagulation or clotting takes place in 3 essential phases. The first phase is the activation of a prothrombin activator complex. The second phase is the activation of prothrombin. The third stage is clot formation as a result of fibrinogen cleavage by activated thrombin. The prothrombin activation complex is formed by two pathways each of which results in a different form of the prothrombin activator. The intrinsic mechanism of prothrombin activator formation begins with trauma to the blood or exposure of blood to collagen in a traumatized vessel wall. This usually also results in damage to fragile platelets. The formation of a clot by this mechanism usually takes 1 to 6 minutes. This cascade begins with the activation of factor XII and the release of platelet factor 3 (PF3) from damaged platelets. Activated factor XII cleaves and actives factor XI and prekallikrein (PK). Factor XII is also activated by activated prekallikrein (aPK) in an internal amplification loop. Calcium (Ca++) is required for the initial three steps. The prothrombin activator in the intrinsic pathway is very similar to the activator in the extrinsic pathway. Antithrombin III inhibits the activity of thrombin and also two of the steps in the formation of the activator. Protein C is activated by thrombin and with the Protein S cofactor provides a strong negative feedback in this phase of clot formation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014856
Subclass_of: Protein Activation Pathway
Tree Number: T4.8.45.2
database_cross_reference: NCI:C39132
database_cross_reference: NCI_BioC:C39132

MAP Kinase Activation Pathway
type: Class
subclass of: Protein Activation Pathway
definition: The binding of b-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using b-arrestin as a scaffold, with subsequent activation of a b-arrestin-bound pool of ERK1/2. The receptor-b-arrestin-ERK complexes are localized to endosomal vesicles, and their formation does not result in nuclear translocation of activated ERK1/2 or stimulation of cell proliferation. The function of b-arrestin-bound ERK1/2 is presently unknown. Activation of ERK1/2 by b-arrestin scaffolds may favor the phosphorylation of plasma membrane, cytosolic, or cytoskeletal ERK1/2 substrates, or it may lead to transcriptional activation through the ERK-dependent activation of other kinases. The model depicts b-arrestin scaffolding of the ERK1/2 MAP kinase cascade, based upon data obtained with the protease-activated PAR2 and angiotensin AT1a receptors. A similar mechanism has been proposed for regulation of the JNK3 MAP kinase cascade by AT1a receptors. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014857
Subclass_of: Protein Activation Pathway
Synonym: Role of beta-arrestins in the activation and targeting of MAP kinases
Tree Number: T4.8.45.3
database_cross_reference: NCI:C39002
database_cross_reference: NCI_BioC:C39002

PPAR Pathway
type: Class
subclass of: Protein Activation Pathway
definition: Similar to other nuclear hormone receptors, PPAR acts as a ligand activated transcription factor. Upon binding fatty acids or hypolipidemic drugs, PPARa interacts with RXR and regulates the expression of target genes. These genes are involved in the catabolism of fatty acids. Conversely, PPARg is activated by prostaglandins, leukotrienes, and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPARb is only weakly activated by fatty acids, prostaglandins, and leukotrienes and has no known physiologically relevant ligand. However, data from PPARb null mice suggest PPARb does serve a role in fatty acid metabolism and perhaps in skin proliferation and cancer. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014858
Subclass_of: Protein Activation Pathway
Synonym: Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression
Tree Number: T4.8.45.4
database_cross_reference: NCI:C39199
database_cross_reference: NCI_BioC:C39199

Protein Kinase A Activation Pathway
type: Class
subclass of: Protein Activation Pathway
definition: G-protein coupled receptors (GPCRs) comprise one of the largest gene families of signaling proteins. Residing in the plasma membrane with seven transmembrane domains, GPCRs respond to extracellular stimuli that include catecholamine neurotransmitters, neuropeptides, larger protein hormones, lipids, nucleotides and other biological molecules. When a GPCR binds its extracellular ligand, it interacts with a G-protein to transduce a signal across the membrane into the cellular interior. G-proteins are a heterotrimeric complex containing a Ga subunit with GTPase activity, as well as b and g subunits. Ga can exist in an active state and an inactive state. Ga in the off state has GDP bound and does not activate downstream signaling molecules. When a GPCR is activated by ligand, it stimulates Ga subunits to bind GTP instead of GDP and become active, dissociating from the receptor and from the b/g subunits to activate downstream signaling factors like the enzyme adenylyl cyclase that synthesizes cyclic-AMP (cAMP) from ATP. Ga turns itself back off again with its intrinsic GTPase activity, hydrolyzing GTP to GDP to become inactive. Activated G proteins interact with downstream signaling factors to alter the production of second messenger signaling molecules like inositolphosphates, calcium and cAMP. GPCRs that activate the Gi class of Ga subunits inhibit cAMP production and GPCRs that activate the Gs class of Ga subunits activate cAMP production. cAMP in turn activates the cAMP-dependent protein kinase, protein kinase A (PKA). PKA is a tetramer composed of catalytic subunits and regulatory subunits that repress the catalytic units when they are bound together. The regulatory subunits bind cAMP when it is present and release the catalytic units, releasing their inhibition of the catalytic subunits as well. The catalytic subunits of PKA when they are released and active phosphorylate target substrate proteins on serine and threonine residues, altering the activity of the modifi…
PMOID: PMO:00014859
Subclass_of: Protein Activation Pathway
Synonym: Activation of cAMP-dependent protein kinase, PKA
Tree Number: T4.8.45.5
database_cross_reference: NCI:C39099
database_cross_reference: NCI_BioC:C39099

Protein Kinase C Activation Pathway
type: Class
subclass of: Protein Activation Pathway
definition: G-protein coupled receptors (GPCRs) transduce a variety of signals from the extracellular environment across the plasma membrane. One of the common signaling systems utilized by GPCRs activates protein kinase C (PKC), a ubiquitous family of serine/threonine protein kinases. The pathway leading to PKC activation starts with a class of GPCRs that interact with and activate Gq G-proteins when the receptor has agonist ligand bound. GPCRs that act through Gq include some muscarinic acetylcholine receptors, many peptide receptors, and the 5-HT2 serotonin receptors. Activated Gq with GTP bound activates its downstream target phospholipase C (PLC) to hydrolyze the membrane lipid PIP2, producing IP3 and diacylglycerol (DAG). IP3 is water-soluble and diffuses through the cytoplasm to the ER, where it binds to and opens a calcium channel, releasing calcium stores from inside the ER into the cytoplasm. Calcium alters many cellular processes, in part by binding to regulatory proteins such as calmodulin and calcineurin. The interaction of both DAG and calcium with PKC activates its kinase activity and the phosphorylation of many different protein targets alters their activity. The involvement of PKC in cellular proliferation and the cell cycle is indicated by the activity of tumor promoters like phorbol esters as PKC activators. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014860
Subclass_of: Protein Activation Pathway
Synonym: Activation of PKC through G protein coupled receptor
Tree Number: T4.8.45.6
database_cross_reference: NCI:C39190
database_cross_reference: NCI_BioC:C39190

SRC Tyrosine Kinase Activation Pathway
type: Class
subclass of: Protein Activation Pathway
definition: Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a protein tyrosine kinase. Overexpression of Src leads to tyrosine phosphorylation of multiple protein substrates and cellular transformation. During interphase the Src protein folds back upon itself to stay in the inactive state, with a phosphotyrosine residue in one domain at Tyrosine 529 bound by an SH2 domain in the same protein. Activation of c-Src involves protein-tyrosine phosphatase alpha (PTP-alpha, or RPTP-alpha), a transmembrane protein with a cytoplasmic phosphatase domain. A variety of evidence has indicated that PTP-alpha dephosphorylates c-Src at Tyr529, allowing Src to open up and become activated, and that this activation occurs in association with mitosis. To activate Src, PTP-alpha must first open up the folded Src through binding itself to the phosphorylated Src domain, a process blocked by binding of Grb-2 to PTP-alpha at phosphorylated Tyr789. PTP-alpha phosphorylated at Tyr789 also binds to the Src SH2 domain, causing the Src structure to open at Src Tyr529 to become available for dephosphorylation. During mitosis the mitotic kinase Cdc-2 phosphorylates Src, along with other cellular substrates, and in so doing makes Src more prone to PTP-alpha dephosphorylation and activation. The activity of PTP-alpha toward Src is also regulated by phosphorylation of PTP-alpha by protein kinase C at serines 180 and 204, releasing the inhibition of PTP-alpha by Grb-2. In the normal cell cycle, Src activity is down-regulated after cell division through dephosphorylation by protein phosphatases and phosphorylation by Csk (C-terminal src kinase) and PTP-alpha dephosphorylation returns the cycle to its interphase condition. The regulation of Src activity during mitosis demonstrates how protein phosphorylation can shift the delicate equilibrium of molecular interactions and cellular responses. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014861
Subclass_of: Protein Activation Pathway
Synonym: Activation of Src by Protein-tyrosine phosphatase alpha
Tree Number: T4.8.45.7
database_cross_reference: NCI:C39237
database_cross_reference: NCI_BioC:C39237

SRF Activation Pathway
type: Class
subclass of: Protein Activation Pathway
definition: Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including immediate early genes such as c-fos, fosB, junB, egr-1 and -2, neuronal genes such as nurr1 and nur77, and muscle genes such as actins and myosins. By regulating expression of these genes, SRF controls cell growth and differentiation, neuronal transmission, as well as muscle development and function. SRF can be activated by serum, lysophosphatidic acid (LPA), lipopolysaccharide (LPS), 12-O-tetradecanoylphorbol-13-acetate (TPA), cytokines, tumor necrosis factor-alpha (TNFalpha), agents that increase intracellular Ca2+, T-cell virus1 activator protein, hepatitis B virus activator proteins pX, activated oncogenes and protooncogenes, and extracellular stimuli such as antioxidant and UV light. In serum-starved cells, MAL is predominantly cytoplasmic where it is sequestered by actin monomers. Upon serum stimulation, Rho becomes active and, through its interaction with ROCK and mDia1, causes an accumulation of F-actin and a commensurate decrease in the level of G-actin. As a consequence, MAL is no longer sequestered and is free to translocate to the nucleus where it associates with SRF and activates SRE-mediated gene expression. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014862
Subclass_of: Protein Activation Pathway
Synonym: Role of MAL in Rho-Mediated Activation of SRF
Tree Number: T4.8.45.8
database_cross_reference: NCI:C39145
database_cross_reference: NCI_BioC:C39145

RANBP2-Mediated Sumoylation Transcription Regulation Pathway
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014863
Subclass_of: Regulatory Pathway
Synonym: Sumoylation by RanBP2 regulates transcriptional repression
Tree Number: T4.8.46
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91685
database_cross_reference: NCI_PID:C91685

Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014864
Subclass_of: Regulatory Pathway
Synonym: Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Tree Number: T4.8.47
database_cross_reference: NCI:C91660
database_cross_reference: NCI_PID:C91660

Regulation of Nuclear SMAD2/3 Signaling Pathway
type: Class
subclass of: Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway
PMOID: PMO:00014865
Subclass_of: Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway
Synonym: Regulation of nuclear SMAD2/3 signaling
Tree Number: T4.8.47.1
database_cross_reference: NCI:C91661
database_cross_reference: NCI_PID:C91661

RELA Pathway
type: Class
subclass of: Regulatory Pathway
definition: The rel/NF-kB family of transcription factors regulates the activity of genes involved in the immune response, hematopoiesis, and inflammation. NF-kB is a complex of two proteins, p65 (rel) and p50. NF-kB is held inactive in the cytoplasm by I-kB, until signals initiated by TNF or several other factors lead to the phosphorylation and degradation of I-kB and the subsequent release of NF-kB to bind DNA and activate genes. The activation of transcription by NF-kB requires transcriptional coactivators such as p300 and CBP to interact with the rest of the transcriptional apparatus. These coactivators posses enzyme activity, acting to catalyze the posttranslational acetylation of proteins on lysine groups. Acetylation of histones has been known for some time to occur in transcriptionally active chromatin regions. Histone deacetylase (HDAC) enzymes reverse the acetylation of histones. As with other signals, there an off-switch as well as an on-switch for NF-kB activation. The signal to terminate gene activation by NF-kB involves regulation of NF-kB acetylation. P300 and CBP recruited by NF-kB to the transcriptional complex acetylate RelA. Acetylated NF-kB proteins do not interact with I-kB and so continue stimulating transcription. To turn off NF-kB dependent transcription, the histone deacetylase HDAC3 binds to and deacetylates RelA, which then interacts strongly with I-kB once again and is inactivated. The reformed complex of NF-kB and I-kB is exported from the nucleus to the cytoplasm where it replenishes the pool of inactive NF-kB awaiting the next activation signal. The activity of other proteins may also be regulated by acetylation in a similar manner. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014866
Subclass_of: Regulatory Pathway
Synonym: Acetylation and Deacetylation of RelA in The Nucleus
Tree Number: T4.8.48
database_cross_reference: NCI:C39221
database_cross_reference: NCI_BioC:C39221

Spermatogenesis Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcriptional activation of post-meiotic genes involved in this process such as calspermin and testis angiotensin-converting enzyme. The key role of CREM in sperm formation is demonstrated by the male sterility of mice lacking CREM, the failure of spermatids to develop into mature sperm, and a lack of post-meiotic gene expression in these animals. Prior to meiosis, splice variants of CREM act as antagonists of cAMP-dependent transcriptional activation, but coordinate with spermatogenesis, the potent transcriptional activator CREM tau splice variant is highly expressed. In other tissues CREM activates genes in response to cAMP through phosphorylation and CBP association, but transcriptional activation by CREM in male germ cells is CBP independent. Stimulation of spermatids with follicle-stimulating hormone (FSH) induces cAMP formation, and the association of CREM with the coactivator ACT, although the mechanism regulating the interaction of CREM with ACT is not yet known. A two-hybrid screen looking for ACT interacting factors revealed another surprising component regulating CREM, the kinesin Kif17b. Kinesins are molecular motors that interact with microtubules to transport organelles and other material within the cell. Kif17b is actively exported from the nucleus in a Crm1-dependent manner, so when it is bound to ACT the export of Kif17b excludes CREM-ACT from the nucleus and blocks transcriptional activation by this complex. The mechanism regulating the interaction of Kif17b with ACT to drive CREM activation is not yet known. Although the regulation of transcription by a kinesin is surprising, a functional connection between cytoskeletal elements and transcriptional regulation is not unprecedented, as demonstrated by the transcription factor MIZ-1 that regulates transcription in response to changes in microtubule structure. (Thi…
PMOID: PMO:00014867
Subclass_of: Regulatory Pathway
Synonym: Regulation of Spermatogenesis by CREM
Tree Number: T4.8.49
database_cross_reference: NCI:C39037
database_cross_reference: NCI_BioC:C39037

Stathmin Pathway
type: Class
subclass of: Regulatory Pathway
definition: Stathmin is a ubiquitous, cytosolic 19-kDa protein, that is phosphorylated on up to four sites in response to many regulatory signals within cells. Its molecular characterization indicates a functional organization including an N-terminal regulatory domain that bears the phosphorylation sites linked to a putative alpha-helical binding domain predicted to participate in coiled-coil, protein-protein interactions. In addition to the protein kinases that phosphorylate Stathmin such as CaMK, MAPK, p34cdc2, PKA, a few other proteins have been suggested to interact with stathmin in vivo. One of them was identified as BiP, a member of the hsp70 heat-shock protein family. Another is a previously unidentified, putative serine/threonine kinase, KIS, which might be regulated by stathmin or, more likely, be part of the kinases controlling its phosphorylation state. Finally, proteins CC1 and CC2, predicted to form alpha-helices participating in coiled-coil interacting structures. It has been suggest that the action of antimicrotubule drugs can be affected by stathmin in at least two ways: (a) altered drug binding; and (b) growth arrest at the G2 to M boundary. Mutant p53 breast cancers exhibiting high levels of stathmin may be resistant to antimicrotubule agents. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014868
Subclass_of: Regulatory Pathway
Synonym: Stathmin and breast cancer resistance to antimicrotubule agents
Tree Number: T4.8.50
database_cross_reference: NCI:C39239
database_cross_reference: NCI_BioC:C39239

Sumoylation in Modulation of CtBP-Dependent Gene Response Pathway
type: Class
subclass of: Regulatory Pathway
definition: Covalent attachment of one eukaryotic protein to another is a prominent posttranslational modification and Ubiquitin is the most familiar of the protein modifiers. Recently a new group of ubiquitin-like (Ubl) proteins have come to light. One of the most intriguing of them is SUMO (small ubiquitin-like modifier, 12kDa) also known as Sentrin. SUMO family has been described in vertebrates: SUMO-1 and the closest homologs SUMO-2 and SUMO-3. SUMO have been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, CtBP, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. In the case of the transcription co-repressor CtBP, which can be recruited to the target promoter via interaction with a conserved PxDLS motif in the interacting repressor, CtBP SUMOylation profoundly affected its subcellular localization. SUMOylation occurred at a single Lys residue, Lys428, of CtBP1. Mutating Lys428 into Arg (K428R) shifted CtBP1 from the nucleus to the cytoplasm, while it had little effect on its interaction with the PxDLS motif. The K428R mutation also abolished the ability of CtBP1 to repress the E-cadherin promoter activity. Consistent with the known inhibitory effect of nNOS on the nuclear accumulation of CtBP1, PDZ domain of nNOS inhibits the SUMOylation of CtBP1. The current data indicates that SUMOylation can regulate CtBP1-dependent transcriptional repression. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014869
Subclass_of: Regulatory Pathway
Synonym: SUMOylation as a mechanism to modulate CtBP-dependent gene responses
Tree Number: T4.8.51
database_cross_reference: NCI:C39039
database_cross_reference: NCI_BioC:C39039

Sumoylation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Like ubiquitin, SUMO (small ubiquitin-related modifier) proteins are small protein tags that are conjugated to proteins to modify their function. The ubiquitin system tags proteins for degradation by the proteasome but SUMO conjugation has a range of other functions, stabilizing some proteins and altering their subcellular localization. Sumoylation may also influence ubiquitination and protein stability indirectly. Three different SUMO proteins are conjugated to proteins, SUMO-1, SUMO-2 and SUMO-3. The SUMO-2 and SUMO-3 genes are closely related, with 86% sequence identity while SUMO-1 is less closely related with about 50% sequence identity with SUMO-2 and SUMO-3. These SUMO proteins also have distinct functions, with SUMO-1 conjugated to proteins as a monomer, while SUMO-2 and SUMO-3 are conjugated to proteins as higher molecular weight polymers with SUMO-1 terminating further SUMO addition. SUMO proteins are first activated by adenylation by one enzyme complex (SAE1/SAE2), then transferred to Ubc-9 and finally to the terminal amino group of a lysine side chain in target proteins. The same conjugation system appears to work for all three SUMO proteins. One target of SUMO modification is proteins involved in formation of the PML nuclear bodies, promoting the stability of these structures and perhaps altering their role in transcriptional regulation, cellular proliferation and anti-viral responses. Other targets of SUMO addition include DAXX, p53 and ran-Gap. The transcriptional activation by p53 is increased by SUMO addition. The localization of DAXX to the PML nuclear bodies and the localization of ran-Gap to the nuclear pores are also regulated by SUMO addition. The activity of several transcription factors is altered by sumoylation, including C/EBP proteins, c-Myb, glucocorticoid receptor, androgen receptor, and progesterone receptor. PIAS is a protein that modulates the activity of many different transcription factors perhaps by acting itself as a sumo ligase. …
PMOID: PMO:00014870
Subclass_of: Regulatory Pathway
Synonym: Basic Mechanisms of SUMOylation
Tree Number: T4.8.52
database_cross_reference: NCI:C39242
database_cross_reference: NCI_BioC:C39242

Sumoylation Regulation of Transcriptional Repression Pathway
type: Class
subclass of: Regulatory Pathway
definition: Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptional repression. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014871
Subclass_of: Regulatory Pathway
Synonym: Sumoylation by RanBP2 Regulates Transcriptional Repression
Tree Number: T4.8.53
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39211
database_cross_reference: NCI_BioC:C39211

Telomerase Regulation Pathway
type: Class
subclass of: Regulatory Pathway
PMOID: PMO:00014872
Subclass_of: Regulatory Pathway
Synonym: Regulation of Telomerase
Tree Number: T4.8.54
database_cross_reference: NCI:C91664
database_cross_reference: NCI_PID:C91664

Terc Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Telomerase is an enzyme that replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells that have an unlimited replicative capacity, such as male germ cells and the majority of human cancers, have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential RNA subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase RNA gene (hTERC) are controlled at least in part at the transcriptional level. The hTERC gene is expressed at high levels in cancer cells, and is absent or at low levels in some normal tissues. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014873
Subclass_of: Regulatory Pathway
Synonym: Overview of telomerase RNA component gene hTerc Transcriptional Regulation
Tree Number: T4.8.55
database_cross_reference: NCI:C39248
database_cross_reference: NCI_BioC:C39248

Tert Regulation Pathway
type: Class
subclass of: Regulatory Pathway
definition: Telomerase is an enzyme that replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells that have an unlimited replicative capacity, such as male germ cells and the majority of human cancers, have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential RNA subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase RNA gene (hTERC) are controlled at least in part at the transcriptional level. The hTERT gene is expressed at low levels in cancer cells and is generally undetectable in normal cells. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014874
Subclass_of: Regulatory Pathway
Synonym: Overview of telomerase protein component gene hTert Transcriptional Regulation
Tree Number: T4.8.56
database_cross_reference: NCI:C39249
database_cross_reference: NCI_BioC:C39249

Th2 Cytokine Gene Induction Pathway
type: Class
subclass of: Regulatory Pathway
definition: CD4+ helper T cells differentiate into distinct subtypes, Th1 and Th2. Th2 cells are involved in the response to extracellular helminth parasites and allergic responses and secrete a distinct set of cytokines including IL-4, IL-5 and IL-13. The development and differentiation of T cells is influenced by many factors, including transcription factors such as GATA-3, a transcription factor associated with induction of Th2 cells. Factors that increase cAMP levels in Th2 cells activate p38 kinase, which phosphorylates and activates GATA-3 independently of PKA. Cells expressing GATA-3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. These cytokines are found in a gene cluster together and are regulated coordinately by GATA-3. Binding of GATA-3 in the regulatory regions of these genes alters chromatin structure, increasing accessibility to other transcription factors. Activation of the T cell receptor through interaction with antigen on antigen presenting cells activates NFAT and other transcription factors that cooperate with GATA-3 in inducing Th2 cell differentiation. Dominant negative GATA-3 can repress the secretion of these cytokines and block the airway inflammation that causes asthma. Blocking GATA-3 action such as through antisense treatment has been suggested as a therapeutic strategy to treat asthma. GATA-3 has also been implicated in developmental processes such as the development of the inner ear. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014875
Subclass_of: Regulatory Pathway
Synonym: GATA3 participate in activating the Th2 cytokine genes expression
Tree Number: T4.8.57
database_cross_reference: NCI:C39090
database_cross_reference: NCI_BioC:C39090

Tight Junction Assembly Pathway
type: Class
subclass of: Regulatory Pathway
definition: Epithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. The transmembrane proteins mediate cell adhesion and are thought to constitute the intramembrane and paracellular diffusion barriers. The cytoplasmic 'plaque' contains three major multi-protein complexes consisting largely of scaffolding proteins, the ZO protein complex, the CRB3-Pals1-PATJ complex and the PAR-3-aPKC-PAR-6 complex. The ZO protein complex appears to organize the transmembrane proteins and couple them to other cytoplasmic proteins and to actin microfilaments. Two evolutionarily conserved protein complexes, the CRB3 and PAR complexes are involved in the establishment and maintenance of epithelial cell polarity. Besides these three protein complexes which seem to be constitutively associated at TJs, a number of proteins with different functions has been identified at TJs. These include additional scaffolding proteins like MUPP1 and MAGI-1, adaptor proteins, transcription regulators and RNA processing factors, regulatory proteins like small GTPases and G-proteins, kinases and phosphatases, and heat shock proteins. These are proposed to be involved in junction assembly, barrier regulation, gene transcription, and perhaps other, presently undefined pathways.
PMOID: PMO:00014876
Subclass_of: Regulatory Pathway
Synonym: Tight junction
Tree Number: T4.8.58
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91475
database_cross_reference: NCI_KEGG:C91475

Transport Pathway
type: Class
subclass of: Regulatory Pathway
definition: An elaboration of the sequence of biological or biochemical events that result in the transport of molecules from one physiological space to another.
PMOID: PMO:00014877
Subclass_of: Regulatory Pathway
Tree Number: T4.8.59
database_cross_reference: NCI:C91760

ABC Transporter Pathway
type: Class
subclass of: Transport Pathway
definition: The ATP-binding cassette (ABC) transporters form one of the largest known protein families and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
PMOID: PMO:00014878
Subclass_of: Transport Pathway
Synonym: ABC transporters
Synonym: ATP-Binding Cassette Transporter Pathway
Tree Number: T4.8.59.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91509
database_cross_reference: NCI_KEGG:C91509

Bacterial Secretion System Pathway
type: Class
subclass of: Transport Pathway
definition: Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
PMOID: PMO:00014879
Subclass_of: Transport Pathway
Synonym: Bacterial secretion system
Synonym: Type II Secretion System
Synonym: Type III Secretion System
Synonym: Type IV Secretion System
Tree Number: T4.8.59.2
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38877
database_cross_reference: NCI_KEGG:C38877

Fc Gamma Receptor-Mediated Phagocytosis Pathway
type: Class
subclass of: Transport Pathway
definition: Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsinization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
PMOID: PMO:00014880
Subclass_of: Transport Pathway
Synonym: Fc gamma R-mediated phagocytosis
Tree Number: T4.8.59.3
database_cross_reference: NCI:C91499
database_cross_reference: NCI_KEGG:C91499

Multi-Drug Resistance Factor Pathway
type: Class
subclass of: Transport Pathway
definition: Cancer cells resistant to a diverse set of hydrophobic drugs are known as MDR cells (multidrug-resistant). Large membrane proteins overproduced in MDR cells, belong to a family of transport P-glycoproteins known as ATP-binding cassette transporter proteins (ABC-ATPases). These proteins were initially thought to affect the permeability of cells to drugs, but they were later found to be pumps that remove drugs from cells at the cost of ATP hydrolysis. There are seven major families of ABC(ATP-binding cassette) proteins, two of them are shown on this pathway, MDR/TAP (Multi-Drug Resistance) and MRP (Multi-Drug Resistance Related Proteins). Members of the MDR/TAP subfamily are involved in multi-drug resistance as well as antigen presentation. Additional factors involved in detoxification are the P450 cytochromes (CYPs), glutathione-S-transferase (GST). Lack of MDR3 can cause a form of Progressive Familial Intrahepatic Cholestasis (PFIC), a heterogeneous group of autosomal recessive liver disorders, characterized by early onset of cholestasis that progresses to cirrhosis and liver failure before adulthood. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014881
Subclass_of: Transport Pathway
Synonym: Multi-Drug Resistance Factors
Tree Number: T4.8.59.4
database_cross_reference: NCI:C91308
database_cross_reference: NCI_BioC:C91308

Phagocytosis Pathway
type: Class
subclass of: Transport Pathway
definition: Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
PMOID: PMO:00014882
Subclass_of: Transport Pathway
Synonym: Phagosome
Tree Number: T4.8.59.5
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91809
database_cross_reference: NCI_KEGG:C91809

Protein Cycling Pathway
type: Class
subclass of: Transport Pathway
definition: A representation of the sequence of biological or biochemical events that occur as a protein is cycled between the plasma membrane and endosomal vesicles.
PMOID: PMO:00014883
Subclass_of: Transport Pathway
Synonym: Protein Recycling Pathway
Tree Number: T4.8.59.6
database_cross_reference: NCI:C40421

ErbB3 Receptor Recycling Pathway
type: Class
subclass of: Protein Cycling Pathway
definition: The neuregulins comprise a subfamily of at least four epidermal growth factor (EGF)-like growth factors that influence a variety of cellular events, including proliferation, differentiation, migration, survival, and fate. The most thoroughly examined neuregulin, neu differentiation factor NDF (AKA: neuregulin-1; NRG1; also heregulin, glial growth factor, or acetylcholine receptor-inducing activity), has been shown to play essential roles in the development of cardiac and neural tissues and also has been shown to play a role in the postsynaptic development of the neuromuscular junction. The neuregulins bind to ErbB3 or ErbB4 and can activate the ErbB2 receptor through a heterodimerization mechanism. Heterodimers of ErbB3 and ErbB2, which has no direct ligand, are potent in causing cell transformation. Controlled levels of signaling through ErbB and other growth factor receptors are maintained by keeping a relatively limited amount of receptors at the cell surface. Receptor overexpression can lead to disease states such as the genesis or progression of tumors. Hence, mechanisms must exist for localizing and maintaining a precise concentration of growth factor receptors at the site of signal reception. ErbB2, ErbB3, and ErbB4 are somewhat unique among studied receptor tyrosine kinases in that they exhibit impaired ligand-induced internalization, down-regulation, and degradation. In fact, the rate of degradation is dependent on factors that appear to act independent of ligand binding. Nrdp-1 (Neuregulin receptor degradation protein-1) is one such protein. Ndrp-1 is an E3 ubiquitin ligase that tags ErbB3 for degradation in non-lysosomal compartments. The cycling of ErbB1 is similar to that of EGF receptor and is included for contrast. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014884
Subclass_of: Protein Cycling Pathway
Synonym: Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling
Tree Number: T4.8.59.6.1
database_cross_reference: NCI:C39069
database_cross_reference: NCI_BioC:C39069

GABA Receptor Life Cycle Pathway
type: Class
subclass of: Protein Cycling Pathway
definition: Gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter that acts at synapses through binding to ligand-gated ion channels, the GABA receptors. Clustering of the GABA-A receptor chloride channel alters receptor pharmacology on the cell surface and reduced clustering of the GABA receptor is associated with anxiety. GABA-A interacts with several proteins that modulate its clustering, endocytosis, and recycling or degradation. Plic-1 is a ubiquitin-like protein that binds to GABA-A receptors and causes them to accumulate at inhibitory synapses. Gephyrin interacts with the cytoplasmic domain of GABA-A, and with microtubules, bringing receptors together in plasma microdomains. Curiously, Gephyrin appears to be a bifunctional protein, with a domain involved in molybdenum metabolism. Another protein interacting with the GABA-A receptor is GABARAP, a microtubule-associated protein. Anchoring of the GABA-A receptor to GABARAP helps to cluster the receptor at the synaptic termini and to mediate fast synaptic transmission. GABARAP may mediate interaction of gephyrin with the GABA-A receptor and gephyrin may stabilize clusters by forming multimeric structures. GABARAP and gephyrin may play more of a role in receptor sorting and transport to the cell surface than in anchoring to the cytoplasm, since at inhibitory synapses GABARAP appears to associate with transport vesicles rather than the cell surface. The association of GABARAP with NSF (N-ethyl maleimide sensitive factor), a protein involved in intracellular vesicle transport, supports this hypothesis. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014885
Subclass_of: Protein Cycling Pathway
Synonym: Gamma-aminobutyric Acid Receptor Life Cycle
Tree Number: T4.8.59.6.2
database_cross_reference: NCI:C39089
database_cross_reference: NCI_BioC:C39089

GPCR Desensitization Pathway
type: Class
subclass of: Protein Cycling Pathway
definition: Homologous desensitization of GPCRs results from the binding of b-arrestins (b-arr) to agonist -occupied receptors following phosphorylation of the receptor by GRKs. b-arrestin binding sterically precludes coupling between the receptor and heterotrimeric G proteins, leading to termination of signaling by G proteins effectors. Receptor-bound b-arrestins also act as adapter proteins, binding to components of the clathrin endocytic machinery including clathrin, b2-adaptin (AP-2). Receptor sequestration reflects the dynamin (Dyn)-dependent endocytosis of GPCRs via clathrin-coated pits. Once internalized, GPCRs exhibit two distinct patterns of b-arrestin interaction. Class A GPCRs, for example the b2 adrenergic receptor, rapidly dissociate from b-arrestin upon internalization. These receptors are trafficked to an acidified endosomal compartment, wherein the ligand is dissociated and the receptor dephosphorylated by a GPCR-specific protein phosphatase PP2A isoform, and are subsequently recycled to the plasma membrane. Class B receptors, for example the angiotensin II AT1a receptor, form stable receptor-b-arrestin complexes. These receptors accumulate in endocytic vesicles and are either targeted for degradation or slowly recycled to the membrane via as yet poorly defined routes. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014886
Subclass_of: Protein Cycling Pathway
Synonym: beta-arrestins in GPCR Desensitization
Tree Number: T4.8.59.6.3
database_cross_reference: NCI:C39000
database_cross_reference: NCI_BioC:C39000

Ran Cycling Pathway
type: Class
subclass of: Protein Cycling Pathway
definition: Ran is a member of the Ras family of small GTPases. Ran is an important component of many crucial nucleocytoplasmic transport pathways. The cycling of Ran is controlled by the RanGTP-RanGDP gradient established by the Ran Guanine nucleotide exchange Factor (RanGEF) RCC1 and the Ran GTPase-activating Protein (RanGAP). These two proteins combine to create a Ran gradient where RanGDP is predominantly cytoplasmic. RCC1 binds to chromatin and so RanGTP is found associated with DNA. RCC1 dissociated GDP from Ran and allows GTP to be bound. As Ran leaves the nucleus the two Ran binding proteins, RanBP1 and RanBP2 cooperate with RanGAP to induce GTP hydrolysis of Ran. There are several nuclear import factors that use the Ran gradient as part of their translocation mechanism. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014887
Subclass_of: Protein Cycling Pathway
Synonym: Cycling of Ran in nucleocytoplasmic transport
Tree Number: T4.8.59.6.4
database_cross_reference: NCI:C39214
database_cross_reference: NCI_BioC:C39214

Protein Export Pathway
type: Class
subclass of: Transport Pathway
definition: Protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
PMOID: PMO:00014888
Subclass_of: Transport Pathway
Synonym: Protein Export
Tree Number: T4.8.59.7
database_cross_reference: NCI:C38857
database_cross_reference: NCI_KEGG:C38857

Protein Import into Nucleus Pathway
type: Class
subclass of: Transport Pathway
definition: Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus and cytoplasm. This includes the movement of small molecules and the selective, facilitated transport of large proteins and RNAs. Faithful, continuous NPC assembly is key for maintaining normal physiological function and is closely tied to proper cell division. One of the unexpected developments during the past decade was the realization that the NPC itself probably does not function primarily as a gating mechanism or by directly transporting cargo macromolecules between the nuclear and cytoplasmic compartments. Instead, nuclear trafficking relies on a range of soluble components. Transport factors bind their cargo in one compartment and then move through the NPCs to the other compartment, where the cargo is released. The transport factor then recycles back through the NPC to participate in another round of transport. In many instances, this process is orchestrated by the Ras-superfamily GTPase Ran. Bischoff et al. describe in detail how the nucleotide state of Ran is controlled by its nuclear guanine-nucleotide-exchange factor (RCC1) and cytoplasmic GTPase-activating protein (RanGAP). The nucleotide state of Ran is crucial to defining the interactions between transport factors, their cargoes and nucleoporins, and is fundamental to the sorting mechanism that defines the directionality of transport. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014889
Subclass_of: Transport Pathway
Synonym: Mechanism of Protein Import into the Nucleus
Tree Number: T4.8.59.8
database_cross_reference: NCI:C39171
database_cross_reference: NCI_BioC:C39171

Rab GTPases in Endocytosis Pathway
type: Class
subclass of: Transport Pathway
definition: The eukaryotic cell contains compartments with distinct functions bounded by lipid bilayer membranes. The movement of membrane vesicles between these compartments allows proteins in the secretory pathway to move outward from the endoplasmic reticulum (ER) to the Golgi, trans Golgi network (TGN), secretory vesicles, and the plasma membrane and to be secreted into the extracellular environment. The trafficking of membrane vesicles is also essential for endocytosis and the movement of material from the extracellular environment into the early endosome (EE), late endosome (LE), and lysosome. The movement of vesicles and their contents between these compartments, and their secretion, are essential for a host of cellular functions, including the release of neurotransmitters and hormones. The movement of membrane vesicles between all of these compartments is regulated by members of the Rab family of GTPases, part of the ras superfamily of genes, regulated through binding of GTP and hydrolysis of bound GTP to GDP. At least eleven yeast genes in this family have been identified as Ypts, yeast transport proteins, and over sixty mammalian Rab genes have been identified in this highly conserved gene family. The products of the Rab genes regulate specific steps in vesicle transport. Rab1 is involved in the movement of membranes from the ER through the Golgi. Rab3 regulates secretory vesicle release and Rab27 is also involved in regulated release of secreted proteins. Rab5, 7 and 9 contribute to endocytosis while Rab4 and Rab11 mediate recycling from the endosome back to the plasma membrane. Rab11 is involved in both endocytosis and exocytosis. As with other Ras family GTPases, the activity of Rabs is regulated by guanine-nucleotide exchange factors (GEFs) and GAPs (GTPase activating proteins). Downstream effectors must also interact with Rabs to transmit their signals regulating each step of the membrane trafficking pathways including vesicle formation, movement of vesicles betw…
PMOID: PMO:00014890
Subclass_of: Transport Pathway
Synonym: Rab GTPases Mark Targets in the Endocytotic Machinery
Tree Number: T4.8.59.9
database_cross_reference: NCI:C39207
database_cross_reference: NCI_BioC:C39207

SNARE Proteins Vesicular Transport Pathway
type: Class
subclass of: Transport Pathway
PMOID: PMO:00014891
Subclass_of: Transport Pathway
Synonym: SNARE interactions in vesicular transport
Tree Number: T4.8.59.10
database_cross_reference: NCI:C91429
database_cross_reference: NCI_KEGG:C91429

Synaptic Vesicle Endocytosis Pathway
type: Class
subclass of: Transport Pathway
definition: Reliable neurotransmitter release requires the presence of sufficient numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) is coordinated by a group of proteins called dephosphins. The current set of seven known dephosphins are nerve terminal proteins with little or no structural homology but satisfy two essential criteria: they are essential for SVE and they are rapidly and coordinately dephosphorylated in response to a calcium influx through voltage-dependent calcium channels. The calcium signal is mediated by calmodulin (CaM) and calcineurin. Each dephosphin plays an essential role in overlapping phases or segments of the cycle. The four phases of SVE are nucleation, invagination, fission and uncoating. The nucleation phase initiates with the activation of CaM/Calcineurin and the subsequent dephosphorylation of AP180. AP180 and clathrin are then recruited to the membrane by AP2 and PtdIns(4,5)P2. Nucleation is completed by the addition of epsin and eps15. Invagination proceeds with the formation of the amphiphysin1/2 heterodimer and its addition to the maturing vesicle surface complexes. The final components, dynamin and synaptojanin, are recruited to the budding vesicle by the amphiphysin1/2 heterodimer. Dynamin forms a complete ring around the vesicle neck and completes fission via its PtdIns(4,5)P2 stimulated GTPase activity. After internalization the vesicle is quickly uncoated, in a process believed to be mediated by synaptojanin, and is accompanied by the disassembly of clathrin. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014892
Subclass_of: Transport Pathway
Synonym: Endocytotic role of NDK, Phosphins and Dynamin
Synonym: SVE Pathway
Tree Number: T4.8.59.11
database_cross_reference: NCI:C39161
database_cross_reference: NCI_BioC:C39161

Vesicle Transport Pathway
type: Class
subclass of: Transport Pathway
definition: Eukaryotic cells take up constituents of the extra-cellular environment and regulate the cell-surface level of membrane proteins via a recycling system of membrane vesicles called endosomes. When cells are taking up elements from the cell-surface it is called endocytosis, and when they are delivered to the cell-surface it is called exocytosis. The transferrin receptor (TfR) is often employed as a model protein for studying this process. The transferrin receptor mediates uptake of iron by binding diferrictransferrin (Tf-2Fe++) from the plasma. Endocytosis of the receptor is initiated by the formation of a clathrin-coated pit in the cell membrane, which subsequently forms the primary endosome and then fuses with the early endosome. The lumen of an early endosome has a slightly acidic pH, which enables the ions to be released. The ions move to the cytosol and the receptor-apotransferrin (Tf) complex is sorted for recycling back to the cell membrane in recycling endosomes. At the cell surface the apotransferrin is replaced with diferrictransferrin and the cycle repeats. Whether an endocytosed protein is recycled or not is determined by a sorting process initiated in the early endosome. The early endosome is the first organelle along the endo-lysosomal pathway and it is the major sorting station. Internalized membrane proteins can either be sorted for recycling from the early endosome by a fast route (e.g., TfR) or make it to the late endosome and recycle by a slow route (e.g., angiotensin receptor, AT1R) or be retained in the late endosome and directed to the lysosome for degradation (e.g., epidermal growth factor receptor, EGFR). The early endosome has been suggested to turn into a multi-vesicular late endosome through a maturation process that changes its biochemical composition and morphology. The late endosome is followed by the lysosome, which is the terminal organelle on the endocytic pathway and is devoid of recycling receptors. The lysosome has a very acidic env…
PMOID: PMO:00014893
Subclass_of: Transport Pathway
Synonym: The role of FYVE-finger proteins in vesicle transport
Tree Number: T4.8.59.12
database_cross_reference: NCI:C39056
database_cross_reference: NCI_BioC:C39056

Signaling Pathway
type: Class
subclass of: Biochemical Pathway
definition: An elaboration of the known or inferred interactions involved in a signal transduction pathway.
PMOID: PMO:00014894
Subclass_of: Biochemical Pathway
Synonym: Pathway, Signal
Synonym: Pathways, Signal
Synonym: Signal Pathway
Synonym: Signal Pathways
Synonym: pathway signaling
Synonym: pathways signaling
Synonym: signal pathway
Tree Number: T4.9
database_cross_reference: CHV:0000011337
database_cross_reference: MSH:D015398

Adherens Junction Assembly Pathway
type: Class
subclass of: Signaling Pathway
definition: Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
PMOID: PMO:00014895
Subclass_of: Signaling Pathway
Synonym: Adherens junction
Tree Number: T4.9.1
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91462
database_cross_reference: NCI_KEGG:C91462

Adipocytokine Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin.
PMOID: PMO:00014896
Subclass_of: Signaling Pathway
Synonym: Adipocytokine signaling pathway
Synonym: adipocytokine signaling pathway
Tree Number: T4.9.2
database_cross_reference: GO:GO:0033209
database_cross_reference: GO:GO:0033210
database_cross_reference: GO:GO:0033211
database_cross_reference: NCI:C91486
database_cross_reference: NCI_KEGG:C91486

ADP-Ribosylation Pathway
type: Class
subclass of: Signaling Pathway
definition: ADP-ribosylation factors (ARFs) are 20-kDa guanine nucleotide-binding proteins, members of the Ras GTPase superfamily that were initially recognized and purified because of their ability to stimulate the ADP-ribosyltransferase activity of the cholera toxin A subunit. We now know that they are critical components of several different vesicular trafficking pathways in all eukaryotic cells and activators of specific phospholipase Ds (PLDs). ARF interacts with many proteins and other molecules that regulate its state of activation or are involved in its intracellular function. Arf proteins cycle between GDP-bound, inactive and GTP-bound, active forms, and the cycling is regulated by specific GEPs and GAPs. Members of the Arf GEP family can be grouped into two major subfamilies on the basis of their sequence similarities and functional differences. The high-molecular-weight Arf GEP subfamily includes yeast Sec7, Gea1, and Gea2, and mammalian BIG1/p200, BIG2, and GBF1, which all consist of 1,400-2,000 amino acid residues. Many Arf GAPs are multidomain proteins and have been found to interact with multiple signaling molecules. For instance, ASAP1 has a PH domain, ankyrin (ANK) repeats, proline-rich and Src-homology (SH) 3 domains and has been shown to bind PI, P2, Src, and Crk. PAPa/PAG3, with a similar domain structure, binds phosphoinositides, Src, Pyk, and paxillin. The GITs bind bARK, paxillin and the Rac/Cdc42 exchange factor PIX (also known as Cool). ASAP-related proteins, ARAP1, 2 and 3 have Arf GAP, Rho GAP, Ankyrin repeat, Ras-associating (RA), and five PH domains, and therefore have the potential of integrating four signaling pathways. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014897
Subclass_of: Signaling Pathway
Synonym: ADP-Ribosylation Factor
Tree Number: T4.9.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C38989
database_cross_reference: NCI_BioC:C38989

AHR Signal Transduction Pathway
type: Class
subclass of: Signaling Pathway
definition: The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus and heterodimerizes with the transcription factor ARNT. The Ah receptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and NAD(P)H quinone oxidoreductase. The inactive form of the Ah receptor exists in the cytoplasm as a tetrameric complex composed of the ligand binding subunit, a dimer of the 90-kDa heat shock protein, and X-associated protein 2 (also referred to as AIP or ARA9). (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014898
Subclass_of: Signaling Pathway
Synonym: Ahr Signal Transduction Pathway
Tree Number: T4.9.4
database_cross_reference: NCI:C38972
database_cross_reference: NCI_BioC:C38972

AKT Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activate the kinase PDK1, 3-phosphoinositide-dependent protein kinase-1, which in turn activates the kinase AKT, also known as protein kinase B. Proteins phosphorylated by activated AKT promote cell survival. Phosphorylation of Ikappa-B kinase leads to activation of the transcription factor NF-kB to oppose apoptosis. Bad is a protein in the Bcl-2 gene family that opposes Bcl-2 to induce apoptosis. Phosphorylation of Bad by AKT blocks anti-apoptotic activity to promote cell survival. Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors. AKT promotes cell survival and opposes apoptosis by a variety of routes. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014899
Subclass_of: Signaling Pathway
Tree Number: T4.9.5
database_cross_reference: NCI:C38981
database_cross_reference: NCI_BioC:C38981

Alpha-Synuclein Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014900
Subclass_of: Signaling Pathway
Synonym: Alpha-synuclein signaling
Tree Number: T4.9.6
database_cross_reference: NCI:C91535
database_cross_reference: NCI_PID:C91535

Alternative NF-kappaB Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014901
Subclass_of: Signaling Pathway
Synonym: Alternative NF-kappaB pathway
Tree Number: T4.9.7
database_cross_reference: NCI:C91536
database_cross_reference: NCI_PID:C91536

Androgen-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014902
Subclass_of: Signaling Pathway
Synonym: Androgen-mediated signaling
Tree Number: T4.9.8
database_cross_reference: NCI:C91538
database_cross_reference: NCI_PID:C91538

Androgen Receptor Regulation Pathway
type: Class
subclass of: Androgen-Mediated Signaling Pathway
PMOID: PMO:00014903
Subclass_of: Androgen-Mediated Signaling Pathway
Synonym: Regulation of Androgen receptor activity
Synonym: regulation of androgen receptor activity
Tree Number: T4.9.8.1
database_cross_reference: GO:GO:2000823
database_cross_reference: NCI:C91659
database_cross_reference: NCI_PID:C91659

Coregulation Pathway for Androgen Receptor Activity
type: Class
subclass of: Androgen-Mediated Signaling Pathway
PMOID: PMO:00014904
Subclass_of: Androgen-Mediated Signaling Pathway
Synonym: Coregulation of Androgen receptor activity
Tree Number: T4.9.8.2
database_cross_reference: NCI:C91568
database_cross_reference: NCI_PID:C91568

Nongenotropic Androgen Signaling Pathway
type: Class
subclass of: Androgen-Mediated Signaling Pathway
PMOID: PMO:00014905
Subclass_of: Androgen-Mediated Signaling Pathway
Synonym: Nongenotropic Androgen signaling
Tree Number: T4.9.8.3
database_cross_reference: NCI:C91640
database_cross_reference: NCI_PID:C91640

Angiopoietin-1 Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014906
Subclass_of: Signaling Pathway
Synonym: Angiopoietin receptor Tie2-mediated signaling
Synonym: TEK Signaling Pathway
Tree Number: T4.9.9
database_cross_reference: NCI:C91539
database_cross_reference: NCI_PID:C91539

Angiotensin II Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Ang II binding to AT1-R triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and to the small G protein Rac1 but not Cdc42. In turn, Rac1 activates a small G protein-activated kinase whose identity is still controversial, but which has been suggested to be PAK1. Finally, the JNK cascade, including MEKK1, SEK1, and JNK, is activated, causing induction of the c-Jun gene via binding of ATF2 and c-Jun heterodimer to the junTRE2 site. Ang II is closely involved in cardiac remodeling by stimulating synthesis of extracellular matrix proteins. It was recently found that expression of fibronectin by Ang II is transcriptionally regulated by AP-1 complex in cardiac fibroblasts. The collagenase gene, containing AP-1 sites, is also regulated by AP-1 components, including c-Jun. AP-1 activity is also enhanced in Ang II-induced cardiac hypertrophy. Expression of ANF is regulated by AP-1 components. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014907
Subclass_of: Signaling Pathway
Synonym: Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
Tree Number: T4.9.10
database_cross_reference: NCI:C38995
database_cross_reference: NCI_BioC:C38995

Arf1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014908
Subclass_of: Signaling Pathway
Synonym: Arf1 pathway
Tree Number: T4.9.11
database_cross_reference: NCI:C91540
database_cross_reference: NCI_PID:C91540

Arf6 Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014909
Subclass_of: Signaling Pathway
Synonym: Arf6 signaling events
Tree Number: T4.9.12
database_cross_reference: NCI:C91541
database_cross_reference: NCI_PID:C91541

Arf6 Signaling Pathway
type: Class
subclass of: Arf6 Pathway
PMOID: PMO:00014910
Subclass_of: Arf6 Pathway
Synonym: Arf6 downstream pathway
Tree Number: T4.9.12.1
database_cross_reference: NCI:C91542
database_cross_reference: NCI_PID:C91542

Arf6 Trafficking Pathway
type: Class
subclass of: Arf6 Pathway
PMOID: PMO:00014911
Subclass_of: Arf6 Pathway
Synonym: Arf6 trafficking events
Tree Number: T4.9.12.2
database_cross_reference: NCI:C91543
database_cross_reference: NCI_PID:C91543

ATM Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014912
Subclass_of: Signaling Pathway
Tree Number: T4.9.13
database_cross_reference: NCI:C38996
database_cross_reference: NCI_BioC:C38996

Attenuation of GPCR Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The G-protein coupled receptor (GPCR) family transduces extracellular signals across the plasma membrane, activating cellular responses through a variety of second messenger cascades (see PKA and PKC signaling pathways). These receptors provide rapid responses to a variety of stimuli, and are often rapidly attenuated in their signaling. Failure to attenuate GPCR signaling can have dramatic consequences. One method to attenuate GPCR signaling is by removal of the stimulus from the extracellular fluid. At the synapse, removal of neurotransmitter or peptide signaling molecules is accomplished by either reuptake or degradation. Acetylcholine is removed from synapses through degradation by the enzyme acetylcholinesterase. Inhibition of acetylcholinesterase results in prolonged signaling at the neuromuscular junction, and uncontrollable spasms in humans caused by nerve gas or in insects by some insecticides. Inhibition of acetylcholinesterase is also used therapeutically to treat Alzheimer's disease, compensating for the loss of cholinergic neurons. Transporters for serotonin, dopamine, GABA and noradrenaline remove these neurotransmitters from the synapse to terminate signaling. Antidepressants such as Prozac inhibit reuptake of serotonin and many drugs of abuse such as cocaine act by blocking reuptake of dopamine or adrenaline. Reuptake not only terminates signaling, but can also conserve neurotransmitter through recycling back into the presynaptic cell. The next step in the attenuation of GPCR signaling is receptor desensitization, in which receptors are modified to no longer transduce a signal even if the stimulus is still present. Desensitization of GPCRs occurs through protein kinases that phosphorylate the GPCR to turn off signaling. Downstream protein kinases such as PKA and PKC turned on by GPCR signaling can phosphorylate the activated GPCR and other GPCRs to prevent further signaling. G-protein receptor kinases (GRKs) are a family of kinases that specifically p…
PMOID: PMO:00014913
Subclass_of: Signaling Pathway
Synonym: Attenuation of GPCR Signaling
Tree Number: T4.9.14
database_cross_reference: NCI:C38974
database_cross_reference: NCI_BioC:C38974

Atypical NF-kappaB Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014914
Subclass_of: Signaling Pathway
Synonym: Atypical NF-kappaB pathway
Tree Number: T4.9.15
database_cross_reference: NCI:C91545
database_cross_reference: NCI_PID:C91545

BCR Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Significant progress has been made towards delineation of the intrinsic molecular processes that regulate B lymphocyte immune function. Recent observations have provided a clearer picture of the interactive signaling pathways that emanate from the mature B cell antigen receptor (BCR) complex and the different precursor complexes that are expressed during development. Studies have also revealed that the net functional response to a given antigenic challenge is affected by the combined action of BCR-dependent signaling pathways, as well as those originating from various coreceptors expressed by B cells (e.g. CD19, CD22, FcgRIIb and PIR-B).It is now well established that reversible tyrosine phosphorylation plays an important role in regulating B cell biology. In particular, binding of antigen to the BCR promotes the activation of several protein tyrosine kinases (PTK) that, in conjunction with protein tyrosine phosphatases (PTP), alter the homeostasis of reversible tyrosine phosphorylation in the resting B cell. The net effect is a transient increase in protein tyrosine phosphorylation that facilitates the phosphotyrosine dependent formation of effector protein complexes, promotes targeting of effector proteins to specific microenvironments within the B cell and initiates the catalytic activation of downstream effector proteins. Studies have demonstrated that Src family PTKs are activated initially and serve to phosphorylate CD79a and CD79b thereby creating phosphotyrosine motifs that recruit downstream signaling proteins. In particular, phosphorylation of the BCR complex leads to the recruitment and activation of the PTK Syk, which in turn promotes phosphorylation of PLCg, Shc and Vav. Additionally, the Tec family member Btk is recruited to the plasma membrane where it is involved in activation of PLCg. Initiation of B lymphocyte activation is dependent on the tyrosine phosphorylation-dependent formation of multi-molecular effector protein complexes that activate down…
PMOID: PMO:00014915
Subclass_of: Signaling Pathway
Tree Number: T4.9.16

Beta-Catenin Accumulation Pathway
type: Class
subclass of: Signaling Pathway
definition: Lipopolysaccharide (LPS) from XX bacteria induces a wide range of inflammatory responses, including the response of alveolar macrophages to bacteria in the lungs. CD14 and the Toll-like receptor TLR4 are activated by LPS, initiating a signaling cascade that activates PI3 kinase and increases synthesis of the inositol phosphate PIP3. PIP3 activates the inositol phosphate dependent protein kinase PDK1, which activates AKT (protein kinase B). One of the key actions of AKT is to block apoptosis. AKT phosphorylation of NF-kB promotes the survival and activation of macrophages responding to LPS. Another substrate of AKT is the protein kinase Gsk3-beta. AKT phosphorylates and deactivates Gsk3-beta. Non-phosphorylated Gsk3-beta is active and phosphorylates beta-catenin, leading to its degradation in the ubiquitin dependent proteasome pathway. Stimulation by LPS causes the accumulation of beta-catenin in the nucleus and the activation of genes in concert with the transcription factor LEF1. This pathway is probably not restricted to alveolar pathway, but leads to the activation of beta-catenin dependent genes by LPS in other cells as well. Other pathways regulate this pathway also, such as the modulation of PI3 kinase activity by ceramide and the inhibition of Gsk3-beta activity by the Wnt/frizzled/disheveled (DSH) pathway. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014916
Subclass_of: Signaling Pathway
Synonym: Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
Tree Number: T4.9.17
database_cross_reference: NCI:C39098
database_cross_reference: NCI_BioC:C39098

Bioactive Peptide Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pressure regulating peptide angiotensin. While these three proteins are distinct in their sequence and physiology, and act through different cell surface receptors, they share in a common class of cell surface receptors called G-protein coupled receptors (GPCRs). Other polypeptide ligands of GPCRs include vasopressin, oxytocin, somatostatin, neuropeptide Y, GnRH, luteinizing hormone, follicle stimulating hormone, parathyroid hormone, orexins, urotensin II, endorphins, enkephalins, and many others. GPCRs form a broad and diverse gene family that responds not only to peptide ligands but also small molecule neurotransmitters (acetylcholine, dopamine, serotonin and adrenaline), light, odorants, taste, lipids, nucleotides, and ions. The main signaling mechanism used by GPCRs is to interact with G-protein GTPase proteins coupled to downstream second messenger systems including intracellular calcium release and cAMP production. The intracellular signaling systems used by peptide GPCRs are similar to those used by all GPCRs, and are typically classified according to the G-protein they interact with and the second messenger system that is activated. For Gs-coupled GPCRs, activation of the G-protein Gs by receptor stimulates the downstream activation of adenylate cyclase and the production of cyclic AMP, while Gi-coupled receptors inhibit cAMP production. One of the key results of cAMP production is activation of protein kinase A. Gq-coupled receptors stimulate phospholipase C, releasing IP3 and diacylglycerol. IP3 binds to a receptor in the ER to cause the release of intracellular calcium, and the subsequent activation of protein kinase C, calmodulin-dependent pathways. In addition to these second messenger signaling systems for GPCRs, GPCR pathways exhibit crosstalk with other signaling pathways including tyrosine kinase growth fa…
PMOID: PMO:00014917
Subclass_of: Signaling Pathway
Synonym: Bioactive Peptide Induced Signaling Pathway
Tree Number: T4.9.18
database_cross_reference: NCI:C39006
database_cross_reference: NCI_BioC:C39006

BMP Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014918
Subclass_of: Signaling Pathway
Synonym: BMP receptor signaling
Synonym: BMP receptor signaling pathway
Synonym: BMP signaling pathway
Synonym: BMP signalling pathway
Synonym: Bone Morphogenic Protein Receptor Family Signaling Pathway
Synonym: bone morphogenetic protein signaling pathway
Synonym: bone morphogenetic protein signalling pathway
Tree Number: T4.9.19
database_cross_reference: GO:GO:0030509
database_cross_reference: NCI:C91552
database_cross_reference: NCI_PID:C91552

Calcium-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
PMOID: PMO:00014919
Subclass_of: Signaling Pathway
Synonym: Calcium signaling pathway
Tree Number: T4.9.20
database_cross_reference: NCI:C91460
database_cross_reference: NCI_KEGG:C91460

Canonical NF-kappaB Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014920
Subclass_of: Signaling Pathway
Synonym: Canonical NF-kappaB pathway
Tree Number: T4.9.21
database_cross_reference: NCI:C91558
database_cross_reference: NCI_PID:C91558

CCR3 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response in inflammation is absent in mice lacking CCR3, indicating the key role of this G protein coupled receptor in inflammation and allergic responses. Eotaxin is a chemokine ligand for CCR3 that recruits eosinophils to the site of inflammation and activates them. Other chemokine ligands of CCR3 include eotaxin-2, MCP-3, MCP-4, and RANTES. Multiple signaling pathways activated by CCR3 participate in the inflammatory response of eosinophils. Eotaxin stimulates intracellular calcium release, production of reactive oxygen species, and changes in actin polymerization through a pertussis sensitive pathway. Rho is a G protein that activates ROCK, a protein kinase. Rho and ROCK regulate actin stress fiber formation and are required for eosinophil chemotaxis. Map kinase pathways are also involved in chemotaxis. Another key action of activated eosinophils is the release of reactive oxygen species, causing tissue damage during chronic inflammatory responses. Blocking eosinophil activation and the signaling pathways that lead to chemotaxis, degranulation, and reactive oxygen release may alleviate inflammatory conditions and inflammation-associated tissue damage. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014921
Subclass_of: Signaling Pathway
Synonym: CCR3 signaling in Eosinophils
Tree Number: T4.9.22
database_cross_reference: NCI:C39017
database_cross_reference: NCI_BioC:C39017

CCR5 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection. One mechanism of signaling by these GPCRs is through activation of Gi signaling. These chemokine receptors can also signal through a Gi-independent pertussis toxin-insensitive pathway. This pathway elevates calcium influx into the cell through CRAC channels, ion channels that are activated by calcium release. Elevated calcium from CRAC is required for downstream activation of Pyk2, a focal adhesion-associated protein kinase. Non Gi signaling by these chemokine receptors also involves the Jnk and p38 Map kinase pathways leading to AP-1 activation and activation of genes such as MIP-1 and MCP-1. This pathway may be involved in the role of macrophages in the pathogenesis of AIDS. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014922
Subclass_of: Signaling Pathway
Synonym: Pertussis toxin-insensitive CCR5 Signaling in Macrophage
Tree Number: T4.9.23
database_cross_reference: NCI:C39018
database_cross_reference: NCI_BioC:C39018

CD40/CD40L Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014923
Subclass_of: Signaling Pathway
Synonym: CD40/CD40L signaling
Tree Number: T4.9.24
database_cross_reference: NCI:C91561
database_cross_reference: NCI_PID:C91561

CD40L Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The CD40 receptor was first associated with expression in B cells and the role it plays through its ligand CD40L (CD154) in moderating T cell activation. Broader expression may indicate a broader role for CD40 and CD40L in immune function and disease states such as transplant rejection and HIV infection. Disruption and modulation of CD40 interaction with CD40L may prove therapeutic in the treatment of autoimmune disorders, heart disease, and cancer. As a member of the TNF receptor family, CD40 relies on interaction with TRAF proteins to mediate an intracellular signal in response to CD40L binding. The pathway downstream of TRAFs activates the transcription factor NF-kappaB through a kinase pathway involving map kinases, NIK (NF-kappaB inducing kinase) and I-kappa B kinases. Some CD40 responses like regulation of immunoglobulin expression might be mediated by NF-kappaB transcriptional activation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014924
Subclass_of: Signaling Pathway
Tree Number: T4.9.25
database_cross_reference: NCI:C39019
database_cross_reference: NCI_BioC:C39019

Cell Adhesion Molecule Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell-cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
PMOID: PMO:00014925
Subclass_of: Signaling Pathway
Synonym: CAM Signaling Pathway
Synonym: Cell adhesion molecules (CAMs)
Tree Number: T4.9.26
database_cross_reference: NCI:C91461
database_cross_reference: NCI_KEGG:C91461

Cell to Cell Adhesion Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Interactions between cells, responsible for cell to cell adhesion, can communicate signals into the cellular interior. These signals often involve interactions with cytoskeletal elements to produce changes in cell motility, migration, proliferation and shape. The cadherins are cell surface adhesion molecules that help form tight junctions between cells, such as in formation of epithelial cell layers. E-cadherin inactivation has been implicated in cancer development. In addition to mediating adhesion with other cells, cadherins transduce signals into cells through interactions with the catenins. Catenins probably affect actin cytoskeletal function through interactions with proteins such as actinin and vinculin. Catenins also probably trigger changes in cell shape and motility by signals through the Rho small GTPases. Another important cell adhesion molecule is CD-31, or PECAM-1, involved in the formation of junctions between endothelial cells, cell migration, migration of lymphocytes, and regulation of lymphocyte activation. Src phosphorylates PECAM-1 on tyrosine residues causing SHP-2 association with PECAM-1. Paxillin acts as an adaptor protein between proteins involved in adhesion signaling like FAK and src and cytoskeletal elements. In addition to signals created by adhesion molecules to alter cellular responses, other signaling pathways can alter adhesion through components of the focal adhesion complex. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014926
Subclass_of: Signaling Pathway
Synonym: Cell to Cell Adhesion Signaling
Tree Number: T4.9.27
database_cross_reference: NCI:C39024
database_cross_reference: NCI_BioC:C39024

Ceramide Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
definition: Ceramide is a sphingosine-based lipid-signaling molecule involved in the regulation of cellular differentiation, proliferation, and apoptosis. This diagram represents some of the current understanding of the cascades that couple ceramide to specific signaling pathways. These cascades illustrate that ceramide can be a growth stimulus or proapoptotic signal. The ultimate ceramide action is determined within the context of other stimuli and by the subcellular topology of its production and is cell-type specific. There are 2 forms of sphingomyelinase, acid (acid-sphingomyelinase, A-SMase) and neutral (neutral-sphingomyelinase, N-SMase), that can produce ceramide. TNF-alpha can stimulate either form of sphingomyelinase as can other death receptors. Different domains of TNF-alpha stimulate the different SMases. N-SMase stimulation is enhanced by the receptor for activated-C kinase 1 (RACK1). The activity of each form is dependent on the local intracellular pH. In the illustration the forms are separated to reduce confusion however ceramide produced by either method can stimulate either cascade depending on the presence of specific co-factors and activators. A-SMase has been recognized as one of the required molecules to mediate proapoptotic signaling in cell death induced by a diverse array of stresses such as H2O2, Heat, UV exposure and Radiation. ROS generation in mitochondria activates caspase-3 via cooperation of cytochrome c, Aif and caspase-9 and stimulates or increases ceramide generation through A-SMase in a proapoptotic activation cycle. Caspase-3 further increases its own activation by proteolytically cleaving ceramide inhibited catalase which is an inhibitor of ROS generation. Ceramide-activated protein kinase(CARK) also known as Kinase Suppressor of RAS (KSR) activity is in some cases the switch point in the balance between proapoptotic and antiapoptotic signals and is also cell-type specific. In endothelial cells for example the activation of KSR is required …
PMOID: PMO:00014927
Subclass_of: Signaling Pathway
Synonym: Ceramide Signaling Pathway
Tree Number: T4.9.28
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39026
database_cross_reference: NCI_BioC:C39026

Ceramide Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014928
Subclass_of: Signaling Pathway
Synonym: Ceramide signaling pathway
Synonym: ceramide signaling pathway
Tree Number: T4.9.29
database_cross_reference: GO:GO:0090520
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91563
database_cross_reference: NCI_PID:C91563

Class I PI3K Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014929
Subclass_of: Signaling Pathway
Synonym: Class I PI3K signaling events
Tree Number: T4.9.30
database_cross_reference: NCI:C91565
database_cross_reference: NCI_PID:C91565

PI3K/AKT1 Signaling Pathway
type: Class
subclass of: Class I PI3K Signaling Pathway
PMOID: PMO:00014930
Subclass_of: Class I PI3K Signaling Pathway
Synonym: Class I PI3K signaling events mediated by Akt
Tree Number: T4.9.30.1
database_cross_reference: NCI:C91566
database_cross_reference: NCI_PID:C91566

PI3K/Non-Lipid Kinase Signaling Pathway
type: Class
subclass of: Class I PI3K Signaling Pathway
PMOID: PMO:00014931
Subclass_of: Class I PI3K Signaling Pathway
Synonym: Class IB PI3K non-lipid kinase events
Tree Number: T4.9.30.2
database_cross_reference: NCI:C91567
database_cross_reference: NCI_PID:C91567

Cone Cell Visual Signal Transduction Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014932
Subclass_of: Signaling Pathway
Synonym: Visual signal transduction: Cones
Tree Number: T4.9.31
database_cross_reference: NCI:C91698
database_cross_reference: NCI_PID:C91698

CREB Activation Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinases CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Growth and neurotrophic factors also stimulate CREB phosphorylation at Ser133. Phosphorylation occurs at Ser133 via p44/42 MAP Kinase and p90RSK and also via p38 MAP Kinase and MSK1. CREB mutants exhibit deficiencies in spatial learning tasks, while flies overexpressing or lacking CREB show enhanced or diminished learning, respectively. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014933
Subclass_of: Signaling Pathway
Synonym: Transcription factor CREB and its extracellular signals
Tree Number: T4.9.32
database_cross_reference: NCI:C39036
database_cross_reference: NCI_BioC:C39036

CXCR3-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014934
Subclass_of: Signaling Pathway
Synonym: CXCR3-mediated signaling events
Tree Number: T4.9.33
database_cross_reference: NCI:C91569
database_cross_reference: NCI_PID:C91569

CXCR4 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: CXCR4 is a chemokine receptor in the GPCR gene family, and is expressed by cells in the immune system and the central nervous system. In response to binding its ligand SDF-1 (stromal cell-derived factor-1), CXCR4 triggers the migration and recruitment of immune cells. This ligand-receptor pair may also play a role in development of the nervous system. In addition to acting as a chemokine receptor, CXCR4 is a co-receptor for entry of HIV into T cells and ligands of CXCR4, including SDF-1, may help to block HIV infection. Early in the infection of an individual, HIV viruses often are tropic for the CCR5 coreceptor that provides for macrophage entry, then later in infection are tropic for CXCR4 and T cell entry. Viruses that are tropic for CXCR4 are generally syncytium forming, causing T cells to aggregate and be destroyed at a rapid rate. CXCR4 induces downstream signaling by several different pathways. As a GPCR, CXCR4 binding of SDF-1 activates G-protein mediated signaling, including downstream pathways such as ras, and PI3 kinase. PI3 kinase activated by SDF-1 and CXCR4 plays a role in lymphocyte chemotaxis in response to these signals. One endpoint of CXCR4 signaling is the activation of transcription factors such as AP-1 and chemokine regulated genes. JAK/STAT signaling pathways also appear to play a role in SDF-1/CXCR4 signaling. Delineation of the signaling mechanisms utilized by CXCR4 may assist in determining the role of CXCR4 in HIV infection and in the immune response. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014935
Subclass_of: Signaling Pathway
Synonym: C-X-C chemokine receptor CXCR4 signaling pathway
Synonym: CXCR4 signaling pathway
Tree Number: T4.9.34
database_cross_reference: GO:GO:0038159
database_cross_reference: NCI:C39043
database_cross_reference: NCI_BioC:C39043

CXCR4-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014936
Subclass_of: Signaling Pathway
Synonym: CXCR4-mediated signaling events
Tree Number: T4.9.35
database_cross_reference: NCI:C91570
database_cross_reference: NCI_PID:C91570

Cytokine-Cytokine Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
PMOID: PMO:00014937
Subclass_of: Signaling Pathway
Synonym: Cytokine-cytokine receptor interaction
Tree Number: T4.9.36
database_cross_reference: NCI:C91469
database_cross_reference: NCI_KEGG:C91469

Cytosolic DNA-Sensing Pathway
type: Class
subclass of: Signaling Pathway
definition: Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-kappa B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.
PMOID: PMO:00014938
Subclass_of: Signaling Pathway
Synonym: Cytosolic DNA-sensing pathway
Tree Number: T4.9.37
database_cross_reference: NCI:C91504
database_cross_reference: NCI_KEGG:C91504

D4-GDI Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: D4-GDP dissociation inhibitor (D4-GDI) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kDa mature form of D4-GDI to give a 5 kDa and 23 kDa size fragment. The 23 kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014939
Subclass_of: Signaling Pathway
Tree Number: T4.9.38
database_cross_reference: NCI:C39045
database_cross_reference: NCI_BioC:C39045

E-Cadherin Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014940
Subclass_of: Signaling Pathway
Synonym: E-cadherin signaling events
Tree Number: T4.9.39
database_cross_reference: NCI:C91575
database_cross_reference: NCI_PID:C91575

Adherens Junction Formation Pathway
type: Class
subclass of: E-Cadherin Signaling Pathway
PMOID: PMO:00014941
Subclass_of: E-Cadherin Signaling Pathway
Synonym: E-cadherin signaling in the nascent adherens junction
Tree Number: T4.9.39.1
database_cross_reference: NCI:C91577
database_cross_reference: NCI_PID:C91577

Adherens Junction Stabilization Pathway
type: Class
subclass of: E-Cadherin Signaling Pathway
PMOID: PMO:00014942
Subclass_of: E-Cadherin Signaling Pathway
Synonym: Stabilization and expansion of the E-cadherin adherens junction
Tree Number: T4.9.39.2
database_cross_reference: NCI:C91684
database_cross_reference: NCI_PID:C91684

E-Cadherin Signaling Pathway in Keratinocytes
type: Class
subclass of: E-Cadherin Signaling Pathway
PMOID: PMO:00014943
Subclass_of: E-Cadherin Signaling Pathway
Synonym: E-cadherin signaling in keratinocytes
Tree Number: T4.9.39.3
database_cross_reference: NCI:C91576
database_cross_reference: NCI_PID:C91576

ECM-Receptor Interaction Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
PMOID: PMO:00014944
Subclass_of: Signaling Pathway
Synonym: ECM-receptor interaction
Tree Number: T4.9.40
database_cross_reference: NCI:C91515
database_cross_reference: NCI_KEGG:C91515

EGF Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor. Inhibitors of the EGF receptor are being pursued as potential cancer therapies and EGF may stimulate wound healing. Mutation of the EGF receptor has been associated with cancer in humans. The proliferative effects of EGF are signaled through several pathways. Binding of EGF results in EGF receptor dimerization, autophosphorylation of the receptor, and tyrosine phosphorylation of other proteins. The EGF receptor activates ras and the MAP kinase pathway, ultimately causing phosphorylation of transcription factors such as c-Fos to create AP-1 and ELK-1 that contribute to proliferation. Activation of STAT-1 and STAT-3 transcription factors by JAK kinases in response to EGF contributes to proliferative signaling. Phosphatidylinositol signaling and calcium release induced by EGF activate protein kinase C, another component of EGF signaling. Crosstalk of EGF signaling with other pathways make the EGF receptor a junction point between signaling systems. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014945
Subclass_of: Signaling Pathway
Tree Number: T4.9.41
database_cross_reference: NCI:C39058
database_cross_reference: NCI_BioC:C39058

Endothelin Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014946
Subclass_of: Signaling Pathway
Synonym: Endothelins
Tree Number: T4.9.42
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91580
database_cross_reference: NCI_PID:C91580

EGFR-Dependent Endothelin Signaling Pathway
type: Class
subclass of: Endothelin Pathway
PMOID: PMO:00014947
Subclass_of: Endothelin Pathway
Synonym: EGFR-dependent Endothelin signaling events
Tree Number: T4.9.42.1
database_cross_reference: NCI:C91581
database_cross_reference: NCI_PID:C91581

Ephrin A Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014948
Subclass_of: Signaling Pathway
Synonym: EPHA Signaling Pathway
Synonym: EphrinA-EPHA pathway
Tree Number: T4.9.43
database_cross_reference: NCI:C91582
database_cross_reference: NCI_PID:C91582

Ephrin A Forward Signaling Pathway
type: Class
subclass of: Ephrin A Signaling Pathway
PMOID: PMO:00014949
Subclass_of: Ephrin A Signaling Pathway
Synonym: EPHA forward signaling
Tree Number: T4.9.43.1
database_cross_reference: NCI:C91584
database_cross_reference: NCI_PID:C91584

Ephrin A Reverse Signaling Pathway
type: Class
subclass of: Ephrin A Signaling Pathway
PMOID: PMO:00014950
Subclass_of: Ephrin A Signaling Pathway
Synonym: Ephrin A reverse signaling
Tree Number: T4.9.43.2
database_cross_reference: NCI:C91587
database_cross_reference: NCI_PID:C91587

Ephrin A2 Forward Signaling Pathway
type: Class
subclass of: Ephrin A Signaling Pathway
PMOID: PMO:00014951
Subclass_of: Ephrin A Signaling Pathway
Synonym: EPHA2 forward signaling
Tree Number: T4.9.43.3
database_cross_reference: NCI:C91585
database_cross_reference: NCI_PID:C91585

Ephrin B Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014952
Subclass_of: Signaling Pathway
Synonym: EPHB Signaling Pathway
Synonym: EphrinB-EPHB pathway
Tree Number: T4.9.44
database_cross_reference: NCI:C91583
database_cross_reference: NCI_PID:C91583

Ephrin B Forward Signaling Pathway
type: Class
subclass of: Ephrin B Signaling Pathway
PMOID: PMO:00014953
Subclass_of: Ephrin B Signaling Pathway
Synonym: EPHB forward signaling
Tree Number: T4.9.44.1
database_cross_reference: NCI:C91586
database_cross_reference: NCI_PID:C91586

Ephrin B Reverse Signaling Pathway
type: Class
subclass of: Ephrin B Signaling Pathway
PMOID: PMO:00014954
Subclass_of: Ephrin B Signaling Pathway
Synonym: Ephrin B reverse signaling
Tree Number: T4.9.44.2
database_cross_reference: NCI:C91588
database_cross_reference: NCI_PID:C91588

Epidermal Growth Factor Receptor Family Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014955
Subclass_of: Signaling Pathway
Synonym: ErbB receptor signaling network
Tree Number: T4.9.45
database_cross_reference: NCI:C91590
database_cross_reference: NCI_PID:C91590

Epidermal Growth Factor Receptor Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014956
Subclass_of: Signaling Pathway
Synonym: EGF receptor (ErbB1) signaling pathway
Tree Number: T4.9.46
database_cross_reference: NCI:C91579
database_cross_reference: NCI_PID:C91579

Epidermal Growth Factor Receptor Downstream Signaling Pathway
type: Class
subclass of: Epidermal Growth Factor Receptor Pathway
PMOID: PMO:00014957
Subclass_of: Epidermal Growth Factor Receptor Pathway
Synonym: ErbB1 downstream signaling
Tree Number: T4.9.46.1
database_cross_reference: NCI:C91591
database_cross_reference: NCI_PID:C91591

Internalization Pathway for Epidermal Growth Factor Receptor
type: Class
subclass of: Epidermal Growth Factor Receptor Pathway
PMOID: PMO:00014958
Subclass_of: Epidermal Growth Factor Receptor Pathway
Synonym: Internalization of ErbB1
Tree Number: T4.9.46.2
database_cross_reference: NCI:C91628
database_cross_reference: NCI_PID:C91628

EPO Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes for any number of reasons. The signaling mechanism includes multimerization of the receptor upon ligand binding, activation of MAPK cascade, and phosphorylation and activation of Stat5. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014959
Subclass_of: Signaling Pathway
Synonym: EPO signaling pathway
Synonym: Erythropoietin Signaling Pathway
Tree Number: T4.9.47
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39067
database_cross_reference: NCI:C91589
database_cross_reference: NCI_BioC:C39067
database_cross_reference: NCI_PID:C91589

ERBB Family Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family-epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase.
PMOID: PMO:00014960
Subclass_of: Signaling Pathway
Synonym: EGF receptor family signaling pathway
Synonym: ERBB signaling pathway
Synonym: ERBB signalling pathway
Synonym: ErbB signaling
Synonym: ErbB signaling pathway
Tree Number: T4.9.48
database_cross_reference: GO:GO:0038127
database_cross_reference: NCI:C91514
database_cross_reference: NCI_KEGG:C91514

ERBB2 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with a molecular weight of 185 KDa. Unlike other members of the EGFR family, no ligand for Her2 has been found and it usually associates with members of ERBB1 family to form functional heterodimers. It has been shown that it can form dimers with ERBB (EGFR), ERBB3 and ERBB4 as well as gp130 subunits of IL-6 receptor. In at least some cell types, the association between gp130 and HRBB2 is essential for HRBB2-ERBB3 phosphorylation and subsequent MAP kinase signaling. Although ERBB1 can form homodimers, the signaling for ERBB1 is usually transient and the receptor undergoes internalization after ligand binding and activation. EGFR-HER2 complex increases the signaling capacity of EGFR by increasing the ligand affinity as well as the recycling of the heterodimer. Of all the ERBB heterodimers, ERBB2-ERBB3 heterodimers perhaps elicit the strongest signal. Removing ERBB3 from the cell has a drastic effect on ERBB2 mediated signaling and downstream effectors. The clinical importance of HER2 cannot be overstated. In addition, monoclonal antibody (Herceptin) against this receptor has been shown to be an effective treatment of breast cancer patients who have a high level of HER2 over expression. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014961
Subclass_of: Signaling Pathway
Synonym: ERBB2 signaling pathway
Synonym: ERBB2 signalling pathway
Synonym: HER2 signaling pathway
Synonym: NEU signaling
Synonym: Role of ERBB2 in Signal Transduction and Oncology
Synonym: receptor tyrosine-protein kinase erbB-2 signaling pathway
Tree Number: T4.9.49
database_cross_reference: GO:GO:0038128
database_cross_reference: NCI:C39103
database_cross_reference: NCI_BioC:C39103

ERBB2/ERBB3 Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014962
Subclass_of: Signaling Pathway
Synonym: ERBB2-ERBB3 signaling pathway
Synonym: ERBB2-ERBB3 signalling pathway
Synonym: ErbB2/ErbB3 signaling events
Synonym: HER2-HER3 signaling pathway
Tree Number: T4.9.50
database_cross_reference: GO:GO:0038133
database_cross_reference: NCI:C91592
database_cross_reference: NCI_PID:C91592

ERBB4 Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014963
Subclass_of: Signaling Pathway
Synonym: ERBB4 signaling pathway
Synonym: ERBB4 signalling pathway
Synonym: ErbB4 signaling events
Synonym: HER4 signaling pathway
Synonym: receptor tyrosine-protein kinase erbB-4 signaling pathway
Tree Number: T4.9.51
database_cross_reference: GO:GO:0038130
database_cross_reference: NCI:C91593
database_cross_reference: NCI_PID:C91593

Erk1/Erk2 MAPK Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kinase. Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, and MEK and by their effects on development. Signal amplification and the potential for crosstalk appear to be important features of this regulatory network. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014964
Subclass_of: Signaling Pathway
Synonym: Erk1/Erk2 Mapk Signaling pathway
Tree Number: T4.9.52
database_cross_reference: NCI:C39072
database_cross_reference: NCI_BioC:C39072

Erythropoietin Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014965
Subclass_of: Signaling Pathway
Tree Number: T4.9.53

Fas Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
definition: Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligomerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated and then cleave and activate downstream caspases, and a variety of cellular substrates, leading to cell death. Caspases cleave nuclear lamins, causing the nucleus to break down and lose its normal structure. They also cleave DFF, inducing cleavage and degradation of the genome. Other caspase substrates are involved in cytoskeletal structure, cell cycle regulation and signaling pathways. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of Fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of Fas-mediated apoptosis. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014966
Subclass_of: Signaling Pathway
Synonym: FAS signaling pathway ( CD95 )
Tree Number: T4.9.54
database_cross_reference: NCI:C39077
database_cross_reference: NCI_BioC:C39077

FAS Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014967
Subclass_of: Signaling Pathway
Synonym: FAS signaling pathway (CD95)
Tree Number: T4.9.55
database_cross_reference: NCI:C91594
database_cross_reference: NCI_PID:C91594

FGF Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014968
Subclass_of: Signaling Pathway
Synonym: FGF signaling pathway
Tree Number: T4.9.56
database_cross_reference: NCI:C91596
database_cross_reference: NCI_PID:C91596

Formyl Peptide Receptor 1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Neutrophils respond to bacterial infection by releasing reactive oxygen species that kill bacteria and by expressing chemokines that attract other immune cells to the site of infection. The multisubunit enzyme NADPH oxidase, expressed by neutrophils, produces reactive oxygen species that are rapidly released in what is known as the respiratory burst. Activity of the NADPH oxidase is induced by fMLP receptor ligands, formylated peptides from bacteria. The fMLP receptor is a G-protein coupled receptor, FPR-1, that activates Map kinase pathways and phospholipase C. Phospholipase C activation releases IP3 and calcium, activating protein kinase C and also activating the transcription factor NFAT, which contributes to activation of chemokine genes. One of the components of the NADPH oxidase is p47phox. PKC activation phosphorylates p47phox to activate NADPH oxidase activity. Activation of Map kinase cascades leads to Erk1/Erk2 dependent p47phox phosphorylation as well as activation of the Elk-1 transcription factor and chemokine gene expression. Inhibition of p38 did not affect p47phox phosphorylation, indicating that p38 is not involved in Erk1/2 activation of the NADPH oxidase. Inhibition of p38 did inhibit NADPH oxidase though, indicating that other pathways contribute to activation of this enzyme. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014969
Subclass_of: Signaling Pathway
Synonym: fMLP induced chemokine gene expression in HMC-1 cells
Tree Number: T4.9.57
database_cross_reference: NCI:C39082
database_cross_reference: NCI_BioC:C39082

G-Protein Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behavior; in many cases this includes the regulation of gene transcription. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014970
Subclass_of: Signaling Pathway
Synonym: Signaling Pathway from G-Protein Families
Tree Number: T4.9.58
database_cross_reference: NCI:C39096
database_cross_reference: NCI_BioC:C39096

Gamma-Secretase Mediated ErbB4 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The HER4/erbB4 receptor tyrosine kinase is a member of the EGF1 receptor family. HER4 is a receptor for the neuregulins (NRGs), a family of growth and differentiation factors. HER4 can also bind and be activated by heparin-binding EGF growth factor, betacellulin, and epiregulin, members of the EGF family which, unlike the NRGs, are also ligands for the EGF receptor. HER4 mRNA is expressed in several tissues such as heart, brain, kidney, and skeletal muscle, suggesting that this receptor is involved in the development and maintenance of a variety of organs and cell types. It is likely that the control of expression and function of HER4 is important in normal development as well as in disease. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014971
Subclass_of: Signaling Pathway
Synonym: g-Secretase mediated ErbB4 Signaling Pathway
Tree Number: T4.9.59
database_cross_reference: NCI:C39070
database_cross_reference: NCI_BioC:C39070

Glucocorticoid Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014972
Subclass_of: Signaling Pathway
Synonym: Glucocorticoid receptor signaling
Synonym: glucocorticoid receptor signaling pathway
Synonym: glucocorticoid receptor signalling pathway
Tree Number: T4.9.60
database_cross_reference: GO:GO:0042921
database_cross_reference: NCI:C91602
database_cross_reference: NCI_PID:C91602

Glucocorticoid Receptor Regulatory Network
type: Class
subclass of: Glucocorticoid Receptor Signaling Pathway
PMOID: PMO:00014973
Subclass_of: Glucocorticoid Receptor Signaling Pathway
Synonym: Glucocorticoid receptor regulatory network
Tree Number: T4.9.60.1
database_cross_reference: NCI:C91603
database_cross_reference: NCI_PID:C91603

Rapid Glucocorticoid Signaling Pathway
type: Class
subclass of: Glucocorticoid Receptor Signaling Pathway
PMOID: PMO:00014974
Subclass_of: Glucocorticoid Receptor Signaling Pathway
Synonym: Rapid glucocorticoid signaling
Tree Number: T4.9.60.2
database_cross_reference: NCI:C91656
database_cross_reference: NCI_PID:C91656

Glypican Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014975
Subclass_of: Signaling Pathway
Synonym: Glypican pathway
Tree Number: T4.9.61
database_cross_reference: NCI:C91604
database_cross_reference: NCI_PID:C91604

Glypican 1 Signaling Pathway
type: Class
subclass of: Glypican Signaling Pathway
PMOID: PMO:00014976
Subclass_of: Glypican Signaling Pathway
Synonym: Glypican 1 network
Tree Number: T4.9.61.1
database_cross_reference: NCI:C91605
database_cross_reference: NCI_PID:C91605

Glypican 2 Signaling Pathway
type: Class
subclass of: Glypican Signaling Pathway
PMOID: PMO:00014977
Subclass_of: Glypican Signaling Pathway
Synonym: Glypican 2 network
Tree Number: T4.9.61.2
database_cross_reference: NCI:C91606
database_cross_reference: NCI_PID:C91606

Glypican 3 Signaling Pathway
type: Class
subclass of: Glypican Signaling Pathway
PMOID: PMO:00014978
Subclass_of: Glypican Signaling Pathway
Synonym: Glypican 3 network
Tree Number: T4.9.61.3
database_cross_reference: NCI:C91607
database_cross_reference: NCI_PID:C91607

Gonadotropin-Releasing Hormone Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
PMOID: PMO:00014979
Subclass_of: Signaling Pathway
Synonym: GnRH signaling pathway
Tree Number: T4.9.62
database_cross_reference: NCI:C91480
database_cross_reference: NCI_KEGG:C91480

GPCR Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The binding of b-arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kinases, including c-Src, Hck and c-Fgr (Src-TK), to the receptor-b-arrestin complex. Several signaling events have been reported to involve b-arrestin-dependent Src recruitment. These include the regulation of clathrin-dependent beta2-adrenergic receptor endocytosis by tyrosine phosphorylation of dynamin, Ras-dependent activation of the ERK1/2 MAP kinase cascade and stimulation of cell proliferation by beta2-adrenergic and neurokinin NK1 receptors, and stimulation of chemokine CXCR1 receptor-mediated neutrophil degranulation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014980
Subclass_of: Signaling Pathway
Synonym: G protein coupled receptor protein signaling pathway
Synonym: G protein coupled receptor protein signalling pathway
Synonym: G-protein coupled receptor protein signal transduction
Synonym: G-protein coupled receptor protein signaling pathway
Synonym: G-protein coupled receptor signaling pathway
Synonym: G-protein coupled receptor signalling pathway
Synonym: G-protein-coupled receptor protein signaling pathway
Synonym: G-protein-coupled receptor protein signalling pathway
Synonym: GPCR signaling pathway
Synonym: GPCR signalling pathway
Tree Number: T4.9.63
database_cross_reference: GO:GO:0007186
database_cross_reference: NCI:C39001
database_cross_reference: NCI_BioC:C39001

Growth Hormone Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signaling can result in dwarfism and decreases in growth hormone levels with age have been suggested to play a role in the reduced function of some physiological systems. Growth hormone signals a response in cells through the growth hormone receptor, a member of the cytokine receptor gene family. Growth hormone causes the receptor to dimerize, activating the JAK2 protein kinase. The activity of JAK2 mediates many of the downstream responses to growth hormone through phosphorylation of STAT transcription factors, MAP kinases, other kinase cascades and molecules involved in metabolism like IRS-1. Factors like SOCS and SHP-1 appear to play a role in the down regulation of signaling by growth hormone and cytokines. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014981
Subclass_of: Signaling Pathway
Tree Number: T4.9.64
database_cross_reference: NCI:C39092
database_cross_reference: NCI_BioC:C39092

HDAC Class I Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014982
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by HDAC Class I
Tree Number: T4.9.65
database_cross_reference: NCI:C91674
database_cross_reference: NCI_PID:C91674

HDAC Class II Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014983
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by HDAC Class II
Tree Number: T4.9.66
database_cross_reference: NCI:C91675
database_cross_reference: NCI_PID:C91675

HDAC Class III Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014984
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by HDAC Class III
Tree Number: T4.9.67
database_cross_reference: NCI:C91676
database_cross_reference: NCI_PID:C91676

Hedgehog Family-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014985
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by the Hedgehog family
Tree Number: T4.9.68
database_cross_reference: NCI:C91532
database_cross_reference: NCI_PID:C91532

Hedgehog Signaling Events Mediated by Gli Family Proteins
type: Class
subclass of: Hedgehog Family-Mediated Signaling Pathway
PMOID: PMO:00014986
Subclass_of: Hedgehog Family-Mediated Signaling Pathway
Synonym: Hedgehog signaling events mediated by Gli proteins
Tree Number: T4.9.68.1
database_cross_reference: NCI:C91608
database_cross_reference: NCI_PID:C91608

Hedgehog Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes.
PMOID: PMO:00014987
Subclass_of: Signaling Pathway
Synonym: Hedgehog signaling pathway
Synonym: hedgehog signaling pathway
Synonym: smoothened signaling pathway
Synonym: smoothened signalling pathway
Tree Number: T4.9.69
database_cross_reference: GO:GO:0007224
database_cross_reference: NCI:C91516
database_cross_reference: NCI_KEGG:C91516

Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
definition: The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutated forms of the HGF receptor are associated with oncogenesis and metastasis, making the HGF receptor a potential therapeutic target for cancer drugs. Changes in cell motility, cell shape, adhesion, resistance to apoptosis, and anchorage independent growth all contribute to the role of c-Met in cancer. The HGF receptor is a heterodimer with tyrosine kinase activity and associates with a multiprotein complex involved in downstream signal transduction. The HGF receptor can associate with several different signaling systems, including src, Grb2/SOS, PI3 kinase and Gab1. One of the major substrates of the activated HGF receptor tyrosine kinase is the adaptor protein Gab1. Gab1 interacts with Crk and CrkL, two proteins with SH2 and SH3 protein interaction domains that couple to signaling further downstream. The actions of HGF on paxillin, DOCK180, and Rap1, mediated through GAB1 and other members of this complex, alter cell motility. Regulation of Rho, Rac1, and CDC42 pathways in response to HGF all contribute to changes in cellular motility. Another target of the HGF receptor kinase is the focal adhesion kinase, FAK. The activation of FAK induces the formation of focal adhesions, a preliminary step to increased cell motility and tissue invasion by transformed cells, and paxillin phosphorylation may also alter cell adhesion of Met transformed cells. Src and p130cas are required for the role of FAK in HGF induced cellular transformation. HGF also blocks anoikis, the induction of apoptosis through suspension of cells, by acting on Erk and AKT kinases. This activity may contribute to anchorage independent growth of Met transformed cells. Signaling by integrins also plays a key role in the activation of tissue invasive growth by HGF. The alpha6beta4 integrin acts as a cofactor along with Meta to participate in cell growth and pro…
PMOID: PMO:00014988
Subclass_of: Signaling Pathway
Synonym: HGF receptor signaling pathway
Synonym: HGF receptor signalling pathway
Synonym: Hepatocyte Growth Factor Receptor Signaling Pathway
Synonym: Met signaling pathway
Synonym: Signaling of Hepatocyte Growth Factor Receptor
Synonym: hepatocyte growth factor receptor signaling pathway
Tree Number: T4.9.70
database_cross_reference: GO:GO:0048012
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39152
database_cross_reference: NCI_BioC:C39152

Hepatocyte Growth Factor Receptor Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014989
Subclass_of: Signaling Pathway
Synonym: HGF receptor signaling pathway
Synonym: HGF receptor signalling pathway
Synonym: Hepatocyte Growth Factor Receptor Signaling Pathway
Synonym: Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta
Synonym: Met signaling pathway
Synonym: Signaling of Hepatocyte Growth Factor Receptor
Synonym: hepatocyte growth factor receptor signaling pathway
Tree Number: T4.9.71
database_cross_reference: GO:GO:0048012
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39152
database_cross_reference: NCI_BioC:C39152

HIF-2-Alpha Transcription Factor Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014990
Subclass_of: Signaling Pathway
Synonym: HIF-2-alpha transcription factor network
Tree Number: T4.9.72
database_cross_reference: NCI:C91611
database_cross_reference: NCI_PID:C91611

IFN Alpha Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Interferon alpha plays a role in viral infections. Signaling takes place through an IFN receptor complex consisting of two alpha chains (type I receptor) complexed with Jak1 and Tyk2. These kinases phosphorylate Stat1 and Stat2 respectively. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014991
Subclass_of: Signaling Pathway
Synonym: IFN alpha signaling pathway
Tree Number: T4.9.73
database_cross_reference: NCI:C39111
database_cross_reference: NCI_BioC:C39111

IFN Gamma Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Interferon gamma is secreted from CD4+ Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. It plays a role in activating lymphocytes to enhance anti-microbial and anti-tumor effects. In addition it plays a role in regulating the proliferation, differentiation, and response of lymphocyte subsets. Signaling takes place through an IFN Receptor complex consisting of two alpha chains (type I receptor) and two beta chains (type 2 receptor). Upon phosphorylation by Jak1, Stat1 (alpha) transduces the signal into transcriptional events. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014992
Subclass_of: Signaling Pathway
Synonym: IFN gamma signaling pathway
Tree Number: T4.9.74
database_cross_reference: NCI:C39112
database_cross_reference: NCI_BioC:C39112

IGF-1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many different cell types and blocks apoptosis. In vivo IGF-1 acts as an intermediate of many growth hormone responses, and may stimulate the growth of some types of cancer. IGF-1 also provides a mitogenic signal to act as a growth factor for many tissue culture cells. One component of IGF-1 mitogenic signaling is association of the receptor tyrosine kinase with Shc, Grb2, and Sos-1 to activate ras and the Map kinase cascade (raf, Mek, Erk). An endpoint of the Map kinase pathway is modification of transcription factor activity, such as activation of ELK transcription factors. Serum response factor (SRF) and AP-1 contribute to mitogenic signaling by many factors. Phosphorylation of IRS-1 and PI3 kinase activation are also involved in IGF-1 signaling, similar to insulin signaling. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014993
Subclass_of: Signaling Pathway
Tree Number: T4.9.75
database_cross_reference: NCI:C39114
database_cross_reference: NCI_BioC:C39114

IGF1 Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014994
Subclass_of: Signaling Pathway
Synonym: IGF1 pathway
Synonym: Insulin-Like Growth Factor 1 Signaling Pathway
Synonym: Somatomedin C Signaling Pathway
Tree Number: T4.9.76
database_cross_reference: NCI:C91614
database_cross_reference: NCI_PID:C91614

IL1-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014995
Subclass_of: Signaling Pathway
Synonym: IL1-mediated signaling events
Tree Number: T4.9.77
database_cross_reference: NCI:C91617
database_cross_reference: NCI_PID:C91617

IL12 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic cells and macrophages in peripheral tissues act as antigen presenting cells and secrete IL-12 as one component of the antigen response, Th1 differentiation. The role of IL-12 in cellular immunity is largely mediated by the STAT-4 transcription factor. STAT-4 is essential for IL-12 activity and the phenotype of mice lacking STAT-4 is very similar to the phenotype of mice lacking the IL-12 receptor or IL-12. The role of IL-12 in Th1 differentiation may not be to induce the Th1 cell fate, but to stimulate growth of cells determined for the Th1 cell fate by the T-bet transcription factor. Several signaling pathways contribute to IL-12 activation of STAT-4 to regulate cell-mediated immune responses. The JAK kinases such as JAK2 and TYK2 interact with the activated IL-12 receptor and tyrosine phosphorylate the IL-12 receptor and STAT-4. IL-12 also activates a map kinase pathway activating the map kinase kinase MKK6 and p38. Phosphorylation of STAT-4 on serine 721 by p38 contributes to the full transcriptional activation of genes by STAT-4. Some of the events downstream of IL-12 appear to include genes activated indirectly by STAT-4, such as genes activated by the transcription factor ERM. ERM is in the Ets family of transcription factors, is activated by IL-12 and activates IL-12 inducible genes such as Interferon-gamma that are not activated by STAT-4 itself. Interferon-gamma transcription in T cells is also activated by other signals such as from the T cell receptor. Other proteins activated transcriptionally downstream of IL-12 and STAT-4 include the chemokine receptor CCR5 and IL-18 and its receptor. Some viruses, including HIV, repress cell-mediated immunity by blocking IL-12 signaling. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014996
Subclass_of: Signaling Pathway
Synonym: IL12 and Stat4 Dependent Signaling Pathway in Th1 Development
Tree Number: T4.9.78
database_cross_reference: NCI:C39117
database_cross_reference: NCI_BioC:C39117

IL12-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00014997
Subclass_of: Signaling Pathway
Synonym: IL12-mediated signaling events
Synonym: Interleukin-12-Mediated Signaling
Tree Number: T4.9.79
database_cross_reference: NCI:C91615
database_cross_reference: NCI_PID:C91615

IL12/STAT4 Signaling Pathway
type: Class
subclass of: IL12-Mediated Signaling Pathway
PMOID: PMO:00014998
Subclass_of: IL12-Mediated Signaling Pathway
Synonym: IL12 signaling mediated by STAT4
Tree Number: T4.9.79.1
database_cross_reference: NCI:C91616
database_cross_reference: NCI_PID:C91616

IL17 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor for IL-17 is widely expressed throughout the body, including fibroblasts and epithelial cells. Inflammatory responses involving IL-17 probably contribute to arthritis, asthma, skin immune reactions, and autoimmune disorders. Fibroblasts and other cells stimulated by IL-17 are induced themselves to secrete inflammatory and hematopoietic cytokines, including IL-6, IL-8, G-CSF, and Stem Cell Factor (SCF). These cytokines in turn provoke a range of activities, including the stimulation of neutrophil proliferation and differentiation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00014999
Subclass_of: Signaling Pathway
Synonym: IL 17 Signaling Pathway
Tree Number: T4.9.80
database_cross_reference: NCI:C39118
database_cross_reference: NCI_BioC:C39118

IL18 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: IL-18 is a pro-inflammatory cytokine similar in structure and mechanism of action to IL-1 beta. Formation of active IL-18 by macrophages requires cleavage of an inactive precursor by caspase-1 protease, also termed the IL-1 converting enzyme (ICE). One of the key biological responses induced by IL-18 is that, in combination with IL-12, it stimulates Th1 cell differentiation and involvement in immune responses. IL-18 was originally known as interferon-gamma-inducing factor, named after its induction of interferon-gamma production. Up-regulation of Fas ligand in Th1 cells by IL-18 may increase apoptosis of Fas receptor expressing cells that interact with the activated Th1 cells. This induction of apoptosis may allow IL-18 to have anti-tumor activity and may also play a role in chronic inflammatory and autoimmune conditions. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015000
Subclass_of: Signaling Pathway
Synonym: IL 18 Signaling Pathway
Tree Number: T4.9.81
database_cross_reference: NCI:C39119
database_cross_reference: NCI_BioC:C39119

IL1R Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Interleukin-1 (IL-1) is a pro-inflammatory cytokine that signals primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include induction of fever, expression of vascular adhesion molecules, and roles in arthritis and septic shock. The inflammatory activities of IL-1 are partially derived by transcriptionally inducing expression of cytokines such as TNF-alpha and interferons, as well as inducing the expression of other inflammation-related genes. There are two forms of IL-1 encoded by distinct genes, IL-1 alpha and IL-1 beta. IL-1 beta is produced as a 269 amino acid precursor that is cleaved by IL-1beta converting enzyme (ICE) to the active IL-1 beta form that is secreted. IL-1 signaling is opposed by the naturally occurring peptide IL-1 receptor antagonist which is a therapeutic agent for the treatment of arthritis. The type 1 IL-1 receptor protein binds IL-1 beta but requires the IL-1 receptor accessory protein (IL-1RAcP) to transduce a signal. IL-1 binding causes activation of two kinases, IRAK-1 and IRAK-2, associated with the IL-1 receptor complex. IRAK-1 (IL-1 Receptor Associated Kinase) activates and recruits TRAF6 to the IL-1 receptor complex. TRAF6 activates two pathways, one leading to NF-kB activation and another leading to c-jun activation. The TRAF associated protein ECSIT leads to c-Jun activation through the Map kinase/JNK signaling system. TRAF6 also signals through the TAB1/TAK1 kinases to trigger the degradation of I-kB, and activation of NF-kB. The IL-1 signaling cascade represents a highly conserved response to pathogens through evolution, with homologs in insects and even in plants. The signal transduction cascade utilized by IL-1 receptor is similar to that of TNF, resulting in NF-kB activation, and is most similar to that of the Toll-like receptors that also participate in inflammatory signaling responses to pathogen components like endotoxin (see Toll-like receptor pathway). (This definition may be outdated - see the Des…
PMOID: PMO:00015001
Subclass_of: Signaling Pathway
Synonym: Signal transduction through IL1R
Tree Number: T4.9.82
database_cross_reference: NCI:C39120
database_cross_reference: NCI_BioC:C39120

IL2 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Interleukin 2 (IL-2) is a potent cytokine that can lead to cellular activation and proliferation. IL-2 receptors are found on activated B-cells, LPS treated monocytes, and many T-cells. The receptor is formed from three chains, alpha (CD25), beta (CD122), and gamma (CD132). Primary signaling is through the JAK/Stat pathway and MAPKs. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015002
Subclass_of: Signaling Pathway
Synonym: IL 2 signaling pathway
Tree Number: T4.9.83
database_cross_reference: NCI:C39122
database_cross_reference: NCI_BioC:C39122

IL2-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015003
Subclass_of: Signaling Pathway
Synonym: IL2-mediated signaling events
Synonym: Interleukin-2-Mediated Signaling
Tree Number: T4.9.84
database_cross_reference: NCI:C91620
database_cross_reference: NCI_PID:C91620

IL2/PI3K Signaling Pathway
type: Class
subclass of: IL2-Mediated Signaling Pathway
PMOID: PMO:00015004
Subclass_of: IL2-Mediated Signaling Pathway
Synonym: IL2 signaling events mediated by PI3K
Tree Number: T4.9.84.1
database_cross_reference: NCI:C91621
database_cross_reference: NCI_PID:C91621

IL2/STAT5 Signaling Pathway
type: Class
subclass of: IL2-Mediated Signaling Pathway
PMOID: PMO:00015005
Subclass_of: IL2-Mediated Signaling Pathway
Synonym: IL2 signaling events mediated by STAT5
Tree Number: T4.9.84.2
database_cross_reference: NCI:C91622
database_cross_reference: NCI_PID:C91622

IL22 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C. One of the actions of IL-22 appears to be the induction of acute phase inflammatory response in hepatocytes, acting through activation of STATs and transcriptional regulation. A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains. The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor. The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses. The IL-22 soluble receptor may act as an anti-inflammatory agent. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015006
Subclass_of: Signaling Pathway
Synonym: IL22 Soluble Receptor Signaling Pathway
Tree Number: T4.9.85
database_cross_reference: NCI:C39121
database_cross_reference: NCI_BioC:C39121

IL23-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015007
Subclass_of: Signaling Pathway
Synonym: IL23-mediated signaling events
Tree Number: T4.9.86
database_cross_reference: NCI:C91618
database_cross_reference: NCI_PID:C91618

IL27-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015008
Subclass_of: Signaling Pathway
Synonym: IL27-mediated signaling events
Tree Number: T4.9.87
database_cross_reference: NCI:C91619
database_cross_reference: NCI_PID:C91619

IL3 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific alpha chain (70 kD, CD123) and a common beta chain (shared with IL-5 and GM-CSF). Signaling is believed to be primarily through Stat5 and the MAPK pathways. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015009
Subclass_of: Signaling Pathway
Synonym: IL 3 signaling pathway
Tree Number: T4.9.88
database_cross_reference: NCI:C39124
database_cross_reference: NCI_BioC:C39124

IL4 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Interleukin 4 (IL-4) is a cytokine that can lead to development of Th2 cells. The 140 kD IL-4 Receptor (CD124) is found on many cell types, even those of non-hematopoietic origin. The receptor is formed from two chains: IL-4R-alpha and the IL-2R gamma chain (CD132). Primary signaling is through the JAK/Stat6 pathway and MAPKs. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015010
Subclass_of: Signaling Pathway
Synonym: IL 4 signaling pathway
Tree Number: T4.9.89
database_cross_reference: NCI:C39125
database_cross_reference: NCI_BioC:C39125

IL4-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015011
Subclass_of: Signaling Pathway
Synonym: IL4-mediated signaling events
Tree Number: T4.9.90
database_cross_reference: NCI:C91623
database_cross_reference: NCI_PID:C91623

IL5 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: IL-5 is an inflammatory signaling molecule that primarily stimulates eosinophil proliferation, maturation, and activation. Eosinophils are leukocytes involved in inflammatory responses that defend against parasites and cause some aspects of asthma, allergic reactions, and perhaps autoimmune disorders. The action of IL-5 begins with an immune response in tissues, such as activation of macrophages and T cells that secrete IL-1, IL-4, and IL-6. The immune response can lead to IL-5 secretion by T cells, eosinophils, and mast cells. Secreted IL-5 stimulates production and maturation of eosinophils in bone marrow that migrate to tissues in response to eotaxin and release factors that damage tissues, causing some of the undesirable consequences of inflammation. The receptor for IL-5 is a heterodimer of an alpha subunit that is required for IL-5 selective binding and a beta subunit that is also part of the IL-3 and GM-CSF receptors. Binding of IL-5 to the IL-5 receptor at the cell surface activates JAK/STAT signaling pathways that regulate transcription, proliferation, and differentiation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015012
Subclass_of: Signaling Pathway
Synonym: IL 5 Signaling Pathway
Tree Number: T4.9.91
database_cross_reference: NCI:C39126
database_cross_reference: NCI_BioC:C39126

IL6 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Interleukin-6 (IL-6) is a cytokine that provokes a broad range of cellular and physiological responses. In addition to playing a role in inflammation and hematopoiesis, IL-6 is involved in other processes such as neuronal differentiation and bone loss. To produce these effects IL-6 signals through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and gp130, a receptor subunit shared in common with other cytokines in the IL-6 family. Binding of IL-6 to its receptor initiates cellular events including activation of JAK kinases and activation of ras-mediated signaling. Activated JAK kinases phosphorylate and activate STAT transcription factors, particularly STAT3, that move into the nucleus to activate transcription of genes containing STAT3 response elements. The ras-mediated pathway, acting through Shc, Grb-2 and Sos-1 upstream and activating Map kinases downstream, activates transcription factors such as ELK-1 and NF-IL-6 (C/EBP-beta) that can act through their own cognate response elements in the genome. These factors and other transcription factors like AP-1 and SRF (serum response factor) that respond to many different signaling pathways come together to regulate a variety of complex promoters and enhancers that respond to IL-6 and other signaling factors. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015013
Subclass_of: Signaling Pathway
Synonym: IL 6 signaling pathway
Tree Number: T4.9.92
database_cross_reference: NCI:C39127
database_cross_reference: NCI_BioC:C39127

IL6-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015014
Subclass_of: Signaling Pathway
Synonym: IL6-mediated signaling events
Tree Number: T4.9.93
database_cross_reference: NCI:C91624
database_cross_reference: NCI_PID:C91624

IL7 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T cells. Some humans with SCID (severe combined immunodeficiency disease) also have mutation of their IL-7 receptor gene leading to an absence of T cells and greatly impaired B cell production. The IL-7 receptor includes two polypeptides, a gamma chain and an alpha chain. The alpha-chain is unique to the IL-7 receptor while several other cytokines use the same gamma receptor chain as IL-7, including IL-2, IL-4, IL-9, IL-15 and IL-21. Binding of IL-7 to the alpha chain leads to dimerization of the alpha and gamma chains. JAK3 associated with the gamma chain tyrosine phosphorylates the alpha chain after dimerization. The importance of JAK3 in IL-7 signaling is supported by the similarity of the immune defects in JAK3 knockout mice and IL-7 knockout mice. The phosphorylated alpha chain serves as the site for recruiting other signaling molecules to the complex to be phosphorylated and activated, including STAT5, src kinases, PI3 kinase, Pyk2, and Bcl2 proteins. Some targets of IL-7 signaling contribute to cellular survival, including Bcl2 and Pyk2. Other targets contribute to cellular proliferation, including PI3 kinase, src family kinases (lck and fyn) and STAT5. The transcription factor STAT5 contributes to activation of multiple different downstream genes in B and T cells and may contribute to VDJ recombination through alteration of chromatin structure. The cell survival and cell proliferation signals induced by IL-7 combine to induce normal B and T cell development. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015015
Subclass_of: Signaling Pathway
Synonym: IL-7 Signal Transduction
Tree Number: T4.9.94
database_cross_reference: NCI:C39128
database_cross_reference: NCI_BioC:C39128

Insulin Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015016
Subclass_of: Signaling Pathway
Tree Number: T4.9.95
database_cross_reference: NCI:C91625
database_cross_reference: NCI_PID:C91625

Insulin-Mediated Glucose Transport Pathway
type: Class
subclass of: Insulin Pathway
PMOID: PMO:00015017
Subclass_of: Insulin Pathway
Synonym: Insulin-mediated glucose transport
Tree Number: T4.9.95.1
database_cross_reference: NCI:C91626
database_cross_reference: NCI_PID:C91626

Insulin Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The appropriate signaling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a complex with the insulin receptor (IR) and b chains to form the active signaling complex. Through recruitment of adaptor molecules and the activation of RAS, the activated IR can cause transcriptional activation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015018
Subclass_of: Signaling Pathway
Tree Number: T4.9.96
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39130
database_cross_reference: NCI_BioC:C39130

Insulin/Insulin Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
PMOID: PMO:00015019
Subclass_of: Signaling Pathway
Synonym: Insulin signaling pathway
Tree Number: T4.9.97
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91489
database_cross_reference: NCI_KEGG:C91489

Integrin Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals in response to the extracellular matrix including cellular shape, mobility, and progression through the cell cycle. Integrins do not themselves possess a kinase domain or enzymatic activity but rely on association with other signaling molecules to transmit signals. Interactions between the extracellular matrix and the actin cytoskeleton commonly take place at focal adhesions on the cell surface that contain localized concentrations of integrins, signaling molecules, and cytoskeletal elements. Talin forms a direct interaction with the integrin cytoplasmic domain, and interacts with cytoskeletal elements (actin) and signaling factors. Paxillin and CAS also localize in focal adhesions and may serve as a scaffold for other integrin signaling components like FAK and src. Interaction of FAK, CAS and src may be required for integrin regulation of cell cycle progression. The CrkL adaptor protein may regulate downstream integrin signaling. Growth factor signaling pathways and the caveolin receptor exhibit important cross talk with integrin receptors in cellular responses like activation of map kinase, proliferation and motility. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015020
Subclass_of: Signaling Pathway
Tree Number: T4.9.98
database_cross_reference: NCI:C39131
database_cross_reference: NCI_BioC:C39131

Interferon Signaling Modulation Pathway
type: Class
subclass of: Signaling Pathway
definition: Signaling by interferon-gamma stimulates anti-viral responses and tumor suppression through the heterodimeric interferon-gamma receptor. Signaling is initiated by binding of interferon-gamma to its receptor, activating the receptor-associated JAK2 tyrosine kinase to phosphorylate STAT transcription factors that activate interferon responsive genes. Molecular chaperones that modulate or alter protein folding interact with different components of the interferon signaling pathway. One chaperone that modulates interferon signaling is hTid-1, a member of the DnaJ family of chaperones and a co-chaperone for the heat shock protein Hsp70, another molecular chaperone. hTid-1 was found in a two-hybrid screen to bind to JAK2 and also to interact with the interferon-gamma receptor. In addition, hTid-1 and JAK2 also interact with Hsp70. Overexpression of hTid-1 represses transcriptional activation by interferon-gamma and Hsp70 dissociates from these proteins when interferon is added to cells, suggesting that Hsp70 holds Jak2 in an inactive conformation prior to ligand activation, and is released in the presence of agonist to allow the activation of Jak-2 and downstream pathways. hTid-1 and Hsp-70 interact with other signaling proteins as well. One of these is Tax, a protein encoded by the HTLV-1 virus that binds to hTid-1. hTid-1 also represses NF-kB activation by blocking the phosphorylation and inactivation of I-kappaB by the IkappaB kinase beta. Hsp70 plays a significant role in protein unfolding for entry into mitochondria and also interacts with tumor suppressor gene products to produce their anti-proliferative activity. One of the actions of interferon is to induce apoptosis of infected target cells, in part through a mitochondrial dependent mechanism. An interaction between interferon signaling and Hsp70 may alter this mitochondrial apoptosis pathway, perhaps playing a role in interferon-mediated apoptosis of infected or transformed cells. The HTLV-1 Tax protein that inte…
PMOID: PMO:00015021
Subclass_of: Signaling Pathway
Synonym: Chaperones modulate interferon Signaling Pathway
Tree Number: T4.9.99
database_cross_reference: NCI:C39253
database_cross_reference: NCI_BioC:C39253

Interferon-Gamma Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015022
Subclass_of: Signaling Pathway
Synonym: IFN-gamma pathway
Tree Number: T4.9.100
database_cross_reference: NCI:C91613
database_cross_reference: NCI_PID:C91613

Ion Channel and Phorbal Esters Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Molecules transmitting signals into cells often act through receptors in the plasma membrane that stimulate production of second messengers. When activated by a plasma membrane receptor, the enzyme phospholipase C (PLCg) hydrolyzes the membrane lipid phosphatidylinositol (PIP2) into the second messengers diacylglycerol (DAG) and IP3. IP3 releases calcium from intracellular stores into the cytoplasm where calcium alters many cellular activities, including activating protein kinase C. DAG also activates protein kinase C. Biologists often study signaling by artificially manipulating pathways using molecules like ionomycin and phorbol esters as research tools. Ionomycin is a molecule that carries calcium through the plasma membrane to increase the calcium concentration in the cytoplasm and activate protein kinase C without activating phospholipase C. Phorbol esters are molecules that mimic the action of DAG in the activation of protein kinase C, and were originally identified as tumor-promoting agents. The combination of ionomycin and phorbol esters is often used experimentally to study the effect of calcium and DAG signaling in cellular responses like T cell activation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015023
Subclass_of: Signaling Pathway
Tree Number: T4.9.101
database_cross_reference: NCI:C39133
database_cross_reference: NCI_BioC:C39133

Jak-STAT Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
PMOID: PMO:00015024
Subclass_of: Signaling Pathway
Synonym: Jak-STAT signaling pathway
Tree Number: T4.9.102
database_cross_reference: NCI:C91519
database_cross_reference: NCI_KEGG:C91519

LKB1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015025
Subclass_of: Signaling Pathway
Synonym: LKB1 signaling events
Synonym: STK11 Signaling Pathway
Tree Number: T4.9.103
database_cross_reference: NCI:C91631
database_cross_reference: NCI_PID:C91631

Lysophosphatidic Acid Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015026
Subclass_of: Signaling Pathway
Synonym: LPA receptor mediated events
Tree Number: T4.9.104
database_cross_reference: NCI:C91632
database_cross_reference: NCI_PID:C91632

Lysophosphatidic Acid Receptor 4 Signaling Pathway
type: Class
subclass of: Lysophosphatidic Acid Receptor Signaling Pathway
PMOID: PMO:00015027
Subclass_of: Lysophosphatidic Acid Receptor Signaling Pathway
Synonym: LPA4-mediated signaling events
Tree Number: T4.9.104.1
database_cross_reference: NCI:C91633
database_cross_reference: NCI_PID:C91633

Macrophage Stimulating 1 Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: MSP, macrophage-stimulating protein, acts through the transmembrane receptor kinase RON (Stk in mice) to play a role in inflammation and the response to tissue injury. MSP is secreted by the liver into the blood as pro-MSP, an inactive precursor form. MSP is related to clotting factors that are activated by proteolytic cleavage and pro-MSP is itself also activated by cleavage to MSP. Binding of activated MSP heterodimer to RON expressed on macrophages, monocytes and keratinocytes stimulates activation of the RON kinase and second messenger pathways, including PI-3 kinase. Macrophages respond to MSP with changes in cell shape and motility and keratinocytes respond by proliferating. Tissue injury leads to pro-MSP cleavage and activation, and macrophages and keratinocytes that respond to MSP are key cells in tissue injury response, supporting a role for MSP and RON in the response to tissue injury. The interaction of MSP and macrophages at sites of inflammation such as infection also depends on chemotactic factors such as MCP1 and inflammatory cytokines such as IL-1 and TNF that attract and activate immune cells in the affected tissue. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015028
Subclass_of: Signaling Pathway
Synonym: Msp/Ron Receptor Signaling Pathway
Tree Number: T4.9.105
database_cross_reference: NCI:C39157
database_cross_reference: NCI_BioC:C39157

MAPK Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
PMOID: PMO:00015029
Subclass_of: Signaling Pathway
Tree Number: T4.9.106
database_cross_reference: NCI:C38834
database_cross_reference: NCI_KEGG:C38834

MAPKinase Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major groupings and numerous related proteins which constitute interrelated signal transduction cascades activated by stimuli such as growth factors, stress, cytokines and inflammation. The four major groupings are the Erk, JNK or SAPK, p38, and the Big MAPK or ERK5 cascades. Signals from cell surface receptors such as GPCRs and growth factor receptors are transduced, directly or via small G proteins such as ras and rac, to multiple tiers of protein kinases that amplify these signals and/or regulate each other. In some cascades the first activation tier involves the MAPKKKKs, MAP kinase kinase kinase kinases or MAP4K proteins. The next tier are the serine/threonine MAPKKKs, MAP kinase kinase kinase or MAP3Ks such as RAF, TAK, ASK, and MEKK1. This level has the greatest amount of cross-communication currently known. The serine/threonine/tyrosine MAPKKs, MAP Kinase kinases or MAP2Ks, such as the MKK and MEK kinases, are one step up from the MAP kinase cascade, phosphorylating and activating these kinases. The focal tier, the MAPKs or MAP kinases includes JNK1, p38, and ERKs, and are the kinases that give each cascade its name. The endpoints of these cascades include the MAPK activated protein kinases (MAPKAPK) and some of the numerous transcription factors that regulate genes involved in apoptosis, inflammation, cell growth and differentiation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015030
Subclass_of: Signaling Pathway
Tree Number: T4.9.107
database_cross_reference: NCI:C39146
database_cross_reference: NCI_BioC:C39146

Mast/Stem Cell Growth Factor Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015031
Subclass_of: Signaling Pathway
Synonym: KIT Signaling Pathway
Synonym: Kit signaling pathway
Synonym: Kit signalling pathway
Synonym: SCF signaling pathway
Synonym: Signaling events mediated by Stem cell factor receptor (c-Kit)
Synonym: stem cell factor receptor signaling pathway
Synonym: stem cell factor signaling pathway
Tree Number: T4.9.108
database_cross_reference: GO:GO:0038109
database_cross_reference: NCI:C91679
database_cross_reference: NCI_PID:C91679

Mitochondria in Apoptotic Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase pathway. Smac/DIABLO is released from mitochondria and inhibits IAP proteins that normally interact with caspase-9 to inhibit apoptosis. Apoptosis regulation by Bcl-2 family proteins occurs as family members form complexes that enter the mitochondrial membrane, regulating the release of cytochrome c and other proteins. TNF family receptors that cause apoptosis directly activate the caspase cascade, but can also activate Bid, a Bcl-2 family member, which activates mitochondria-mediated apoptosis. Bax, another Bcl-2 family member, is activated by this pathway to localize to the mitochondrial membrane and increase its permeability, releasing cytochrome c and other mitochondrial proteins. Bcl-2 and Bcl-xL prevent pore formation, blocking apoptosis. AIF (apoptosis inducing factor) is another mitochondrial factor that is released into the cytoplasm to induce apoptosis. AIF-induced apoptosis is important during development but is not caspase dependent. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015032
Subclass_of: Signaling Pathway
Synonym: Role of Mitochondria in Apoptotic Signaling
Tree Number: T4.9.109
database_cross_reference: NCI:C39154
database_cross_reference: NCI_BioC:C39154

mTOR Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
definition: mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate translation. The drug rapamycin acts on mammalian cells through the mTOR protein kinase, also known as FRAP. When bound to the immunophilin binding protein FKBP12, rapamycin inhibits mTOR kinase activity and has immunosuppressant activity. Rapamycin and the mTOR inhibitor CCI-779 are being tested as anti-cancer agents, acting to block mitogenic signaling. Recently, mTOR was also found to act as an ATP sensor to regulate cell growth. Upstream activation of PI 3 kinase activity that leads to oncogenic transformation can be blocked by inhibition of mTOR by rapamycin. Growth factor receptors first stimulate PI 3 kinase, and through inositol phosphates activate PDK-1 and AKT (protein kinase B). AKT phosphorylates mTOR. The phosphorylation of p70S6K and 4EBP by mTOR and the phosphorylation downstream of RPS6 and EIF-4B stimulate translational initiation and contribute to cell growth. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015033
Subclass_of: Signaling Pathway
Synonym: mTOR Signaling Pathway
Tree Number: T4.9.110
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39159
database_cross_reference: NCI_BioC:C39159

mTOR Signaling Pathway KEGG
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015034
Subclass_of: Signaling Pathway
Synonym: mTOR signaling pathway
Tree Number: T4.9.111
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91431
database_cross_reference: NCI_KEGG:C91431

mTOR Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015035
Subclass_of: Signaling Pathway
Synonym: mTOR signaling pathway
Tree Number: T4.9.112
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91634
database_cross_reference: NCI_PID:C91634

N-Cadherin Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015036
Subclass_of: Signaling Pathway
Synonym: N-cadherin signaling events
Tree Number: T4.9.113
database_cross_reference: NCI:C91635
database_cross_reference: NCI_PID:C91635

Nectin Adhesion Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015037
Subclass_of: Signaling Pathway
Synonym: Nectin adhesion pathway
Tree Number: T4.9.114
database_cross_reference: NCI:C91636
database_cross_reference: NCI_PID:C91636

Nerve Growth Factor Pathway
type: Class
subclass of: Signaling Pathway
definition: Nerve growth factor (NGF) is one of a family of neurotrophins that induce the survival and proliferation of neurons. In cell culture NGF induces the formation of neurite projections and in vivo may stimulate the innervation of tissues. NGF plays a role in the repair, regeneration, and protection of neurons, and as such could serve as a therapeutic agent in neurodegenerative conditions such as Alzheimer's disease. One potential method of NGF application would be through gene therapy or through implantation of cells that have been genetically modified ex vivo. NGF has also been suggested to play a role in other physiological systems and tissues such as the immune system. NGF has two receptors, TrkA and the p75(NTR). NGF may signal its neuroprotective actions through the tyrosine kinase TrkA receptor and trigger apoptosis in some cells through the p75 receptor. High-affinity binding of NGF requires both TrkA and p75(NTR). Binding of NGF to the TrkA receptor causes activation of the receptor tyrosine kinase and downstream signaling cascades. One of the downstream signaling pathways of NGF activates phospholipase C, releasing DAG and IP3 and activating associated downstream pathways such as protein kinase C. Another NGF-activated pathway is the ras-mediated activation of the map kinase pathway. This pathway is initiated through recruitment and activation of Shc, which leads to ras activation through Grb-2 and Sos-1. The Map kinase cascade includes raf, Mek and Erk. The downstream effectors of the ras pathway include activation of fos and jun to form AP-1, activating genes through this transcription factor. Other transcription factors involved in NGF responses include Egr and CREB. The Egr family of transcription factors, as well as the Mek/Erk pathway, contribute to NGF-induced neurite formation. The CREB family of transcription factors are involved in NGF-induced survival of sympathetic neurons. Further understanding of NGF signaling may be applied to the modulation of …
PMOID: PMO:00015038
Subclass_of: Signaling Pathway
Synonym: Nerve growth factor pathway (NGF)
Tree Number: T4.9.115
database_cross_reference: NCI:C39164
database_cross_reference: NCI_BioC:C39164

Neuroactive Ligand-Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015039
Subclass_of: Signaling Pathway
Synonym: Neuroactive ligand-receptor interaction
Tree Number: T4.9.116
database_cross_reference: NCI:C91438
database_cross_reference: NCI_KEGG:C91438

Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015040
Subclass_of: Signaling Pathway
Synonym: High Affinity Nerve Growth Factor Receptor Signaling Pathway
Synonym: Neurotrophic factor-mediated Trk receptor signaling
Tree Number: T4.9.117
database_cross_reference: NCI:C91638
database_cross_reference: NCI_PID:C91638

NTRK1/MAPK Signaling Pathway
type: Class
subclass of: Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
PMOID: PMO:00015041
Subclass_of: Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
Synonym: Trk receptor signaling mediated by the MAPK pathway
Tree Number: T4.9.117.1
database_cross_reference: NCI:C91695
database_cross_reference: NCI_PID:C91695

NTRK1/PI3K/PLC-Gamma Signaling Pathway
type: Class
subclass of: Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
PMOID: PMO:00015042
Subclass_of: Neurotrophic Factor-Mediated NTRK1 Signaling Pathway
Synonym: Trk receptor signaling mediated by PI3K and PLC-gamma
Tree Number: T4.9.117.2
database_cross_reference: NCI:C91694
database_cross_reference: NCI_PID:C91694

NFKB Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Nuclear factor kB (NF-kB) is a nuclear transcription factor that regulates expression of a large number of genes that are critical for the regulation of apoptosis, viral replication, tumorigenesis, inflammation, and various autoimmune diseases. The activation of NF-kB is thought to be part of a stress response as it is activated by a variety of stimuli that include growth factors, cytokines, lymphokines, UV, pharmacological agents, and stress. In its inactive form, NF-kB is sequestered in the cytoplasm, bound by members of the IkB family of inhibitor proteins, which include IkBa, IkBb, IkBg, and IkBe. The various stimuli that activate NF-kB cause phosphorylation of IkB, which is followed by its ubiquitination and subsequent degradation. This results in the exposure of the nuclear localization signals (NLS) on NF-kB subunits and the subsequent translocation of the molecule to the nucleus. In the nucleus, NF-kB binds with a consensus sequence (5'GGGACTTTCC-3') of various genes and thus activates their transcription. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins; IKK1/IKKa, IKK2/IKKb, and IKK3/IKKg. These enzymes phosphorylate IkB leading to its ubiquitination and degradation. Tumor necrosis factor (TNF) which is the best-studied activator binds to its receptor and recruits a protein called TNF receptor death domain (TRADD). TRADD binds to the TNF receptor-associated factor 2 (TRAF-2) that recruits NF-kB-inducible kinase (NIK). Both IKK1 and IKK2 have canonical sequences that can be phosphorylated by the MAP kinase NIK/MEKK1 and both kinases can independently phosphorylate IkBa or IkBb. TRAF-2 also interacts with A20, a zinc finger protein whose expression is induced by agents that activate NF-kB. A20 functions to block TRAF2-mediated NF-kB activation. A20 also inhibits TNF and IL-1 induced activation of NF-kB suggesting that it may act as a general inhibitor of NF-kB activation. (This definition may be outdated - see the D…
PMOID: PMO:00015043
Subclass_of: Signaling Pathway
Synonym: NF-kB Signaling Pathway
Tree Number: T4.9.118
database_cross_reference: NCI:C39163
database_cross_reference: NCI_BioC:C39163

Nitric Oxide Pathway
type: Class
subclass of: Signaling Pathway
definition: Nitric oxide (NO) has a number of important physiological actions in the cardiovascular system. In the heart, NO plays a role in keeping the vessels open via vasodilation and prevention of platelet aggregation. It also plays an important role in regulating the force and rate of contraction. In vivo NO is released by shear stress of ligands that increase intracellular Ca2+ in endothelial cells. The increased intracellular Ca2+ activates nitric oxide synthase III (NOSIII) by promoting the binding of Ca/Calmodulin to the enzyme. NOSIII, which is resident in the Golgi complex, is transported together with caveolin-1 to the caveolae at the plasma membrane via vesicles. Shear stress signals via a potassium channel and the cytoskeleton, which results in tyrosine phosphorylation of specific proteins, activation of phosphatidylinositol 3-kinase, and subsequently in activation of Akt kinase. Akt activation by shear stress, but also by VEGF, activates NOSIII by serine phosphorylation, which increases the affinity of NOSIII for calmodulin. After agonist binding at the plasma membrane, NOSIII-activating receptors translocate to caveolae. VEGF receptor signals via its tyrosine kinase domain. Furthermore, agonist receptors activate calcium channels of the endoplasmic reticulum (ER) via phospholipase C and inositol 1,4,5-trisphosphate. This calcium flux induces binding of calmodulin to NOSIII, whereas the NOSIII-caveolin-1 interaction is disrupted. At the same time, NOSIII is translocated into the cytosol. On binding of calmodulin, NOSIII generates NO, is enhanced by the interaction with Hsp90. Once activated, NOSIII catabolizes L-arginine to NO, which diffuses out of the cell. NO stimulates guanylate (G-) cyclase and increases cGMP levels. cGMP activates cGMP-dependent protein kinase (PKG), cGMP-inhibited phosphodiesterase (PDEIII), and cGMP-stimulated phosphodiesterase (PDEII). PKG may reduce the force and rate of contraction, possibly by phosphorylating troponin I or by phosphor…
PMOID: PMO:00015044
Subclass_of: Signaling Pathway
Synonym: Actions of Nitric Oxide in the Heart
Tree Number: T4.9.119
database_cross_reference: NCI:C39167
database_cross_reference: NCI_BioC:C39167

Nitric Oxide Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Glutamatergic-mediated nitric oxide (NO) production occurs via the N-methyl-D-aspartic acid (NMDA) postsynaptic density protein 95 (PSD95)-neuronal nitric oxide synthase (NOS1) ternary complex. The increased intracellular Ca2+ stimulates the interaction of nNOS and calmodulin (CaM) and the translocation of nNOS from the plasma membrane to the cytoplasm. The dephosphorylation of nNOS by Calcineurin catalyzes the conversion of arginine to citrulline and nitric oxide (NO), which turns on guanylate cyclase and the various cGMP regulated signaling pathways. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015045
Subclass_of: Signaling Pathway
Tree Number: T4.9.120
database_cross_reference: NCI:C39169
database_cross_reference: NCI_BioC:C39169

NOD-Like Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-kappa-B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway.
PMOID: PMO:00015046
Subclass_of: Signaling Pathway
Synonym: NOD-like receptor signaling pathway
Tree Number: T4.9.121
database_cross_reference: GO:GO:0035872
database_cross_reference: NCI:C91506
database_cross_reference: NCI_KEGG:C91506

Notch and Wnt Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Presenilin-1 (PS1) is associated with gamma secretase activity that cleaves amyloid precursor protein (APP) and is implicated in Alzheimer's disease. Presenilin-1 is also a component in gamma-secretase activity involved in signaling by the transmembrane protein Notch. Active gamma secretase requires PS-1 N-terminal fragment and a C-terminal fragment and is unique in catalyzing proteolysis within the transmembrane region of proteins. Other proteins such as nicastrin may also be components of the gamma-secretase. Binding of the ligand Delta by Notch appears to trigger two proteolytic cleavages of Notch. The first step cleaves an extracellular domain and is catalyzed by a metalloprotease termed alpha-secretase or TACE. The second cleavage step appears to occur within the transmembrane domain of Notch, and releases a Notch intracellular domain (NICD). Once released, NICD moves into the nucleus where it is involved in transcriptional regulation through CSL family transcription factors (CBF1, Su(H), Lag-1) or other transcriptional regulators such as LEF-1. Presenilin is also involved in the Wnt/frizzled signaling pathway through beta-catenin. Beta-catenin is a cytoskeletal component that enters the nucleus to act as a transcriptional cofactor. Binding of WNT to Frizzled causes disheveled (DSH) to inhibit Glycogen synthase kinase 3 beta (GSK-3b) activity. Phosphorylation of Beta-catenin induces the ubiquitination and proteolytic degradation of beta-catenin by the proteasome. Non-phosphorylated beta-catenin is stable and enters the nucleus to regulate transcription with TCF. The beta-catenin/TCF complex activates genes that promote cellular survival, proliferation and differentiation during development. Presenilin stimulates beta-catenin turnover, reducing its transcriptional activation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015047
Subclass_of: Signaling Pathway
Synonym: Presenilin action in Notch and Wnt signaling
Tree Number: T4.9.122
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39202
database_cross_reference: NCI_BioC:C39202

Notch Proteolysis and Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Notch is a large cell-surface receptor that is activated by contact with membrane-bound ligands on neighboring cells. The ligands that activate Notch include Delta and Serrate, and Lag-2 is a Notch ligand in C. elegans. Activation of Notch by binding with its ligand on the surface of neighboring cells is involved in several developmental pathways, helping to determine cell fate. Much of the early insight into Notch signaling was derived from genetic studies in Drosophila and C. elegans models. Three different proteolytic steps process the 300 kD precursor of mature Notch. One protease is a furin-like enzyme that cleaves Notch constitutively adjacent to the amino acid sequence RQRR in the extracellular domain. Another proteolytic step in Notch processing is carried out by TACE, also known as ADAM17. Binding of extracellular ligand to Notch also induces cleavage at the transmembrane region by a gamma-secretase activity that is dependent on presenilin-1. The exact identity of the polypeptide that catalyzes the gamma-secretase enzyme activity has been debated. Labeling of presenilin with irreversible gamma-secretase transition state inhibitors indicates that is itself in fact the site of protease activity. It has also been argued that the gamma secretase is not presenilin-1 itself, but another polypeptide that requires Notch for its activity and is distinct from Presenilin-1. Cleavage of Notch in the extracellular domain releases the Notch intracellular domain (BIOCARTAD) which migrates into the nucleus where it associates with CSL transcription factors and acts as a transcriptional coactivator. The proteolytic processing of Notch resembles in several ways the proteolytic processing of amyloid precursor protein (APP) that is implicated in plaque formation in Alzheimer's disease, with TACE and Presenilin-1 implicated in proteolytic processing of both Notch and APP. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015048
Subclass_of: Signaling Pathway
Synonym: N signaling pathway
Synonym: N signalling pathway
Synonym: Notch Signaling Pathway
Synonym: Notch receptor signaling pathway
Synonym: Notch receptor signalling pathway
Synonym: Notch signaling pathway
Synonym: Notch signalling pathway
Synonym: Notch-receptor signaling pathway
Synonym: Notch-receptor signalling pathway
Synonym: Proteolysis and Signaling Pathway of Notch
Tree Number: T4.9.123
database_cross_reference: GO:GO:0007219
database_cross_reference: NCI:C39170
database_cross_reference: NCI:C91520
database_cross_reference: NCI_BioC:C39170
database_cross_reference: NCI_KEGG:C91520

Notch Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
PMOID: PMO:00015049
Subclass_of: Signaling Pathway
Synonym: N signaling pathway
Synonym: N signalling pathway
Synonym: Notch Proteolysis and Signaling Pathway
Synonym: Notch receptor signaling pathway
Synonym: Notch receptor signalling pathway
Synonym: Notch signaling pathway
Synonym: Notch signalling pathway
Synonym: Notch-receptor signaling pathway
Synonym: Notch-receptor signalling pathway
Synonym: Proteolysis and Signaling Pathway of Notch
Tree Number: T4.9.124
database_cross_reference: GO:GO:0007219
database_cross_reference: NCI:C39170
database_cross_reference: NCI:C91520
database_cross_reference: NCI_BioC:C39170
database_cross_reference: NCI_KEGG:C91520

Olfactory Transduction Pathway
type: Class
subclass of: Signaling Pathway
definition: Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP. Longer exposure to odorants can stimulate particulate guanylyl cyclase in cilia to produce cGMP and activate PKG, leading to a further increase in amount and duration of intracellular cAMP levels, which may serve to convert inactive forms of protein kinase A (PKA2) to active forms (PKA*). As part of a feedback loop, PKA can inhibit the activation of particulate guanylyl cyclase.
PMOID: PMO:00015050
Subclass_of: Signaling Pathway
Synonym: Olfactory transduction
Synonym: olfactory transduction
Tree Number: T4.9.125
database_cross_reference: NCI:C91530
database_cross_reference: NCI_KEGG:C91530
database_cross_reference: NCI_NCI-GLOSS:CDR0000462728

OX40 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Two key features of the immune system are the clonal expansion of B cells and T cells in response to antigens, and the potentiation of future immune responses by long-lived memory cells. CD4-expressing T cells require costimulatory signals along with antigen stimulation to mount an effective immune response. CD28 has been widely characterized as a costimulatory receptor for CD4+ T cells. OX40, also called CD134, is another transmembrane receptor protein expressed by CD4 T cells that provides a costimulatory signal for T cell activation by antigen. The OX40L ligand for OX40 is expressed as a transmembrane protein by antigen-presenting cells, and is required for function of antigen-presenting cells. The T cell costimulatory signal provided by the OX40/OX40L interaction increases the clonal amplification of antigen-specific T cells and the survival of memory T cells that respond to this antigen. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015051
Subclass_of: Signaling Pathway
Tree Number: T4.9.126
database_cross_reference: NCI:C39175
database_cross_reference: NCI_BioC:C39175

p38 MAPK Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
definition: p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, and Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/5. The p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, Max/Myc complex, MEF-2, ELK-1, and indirectly CREB via activation of MSK1. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015052
Subclass_of: Signaling Pathway
Synonym: p38 MAPK Signaling Pathway
Tree Number: T4.9.127
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39178
database_cross_reference: NCI_BioC:C39178

p38 MAPK Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015053
Subclass_of: Signaling Pathway
Synonym: p38 MAPK signaling pathway
Tree Number: T4.9.128
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91642
database_cross_reference: NCI_PID:C91642

p38 MAPK/MAPKAP Signaling Pathway
type: Class
subclass of: p38 MAPK Signaling Pathway PID
PMOID: PMO:00015054
Subclass_of: p38 MAPK Signaling Pathway PID
Synonym: p38 signaling mediated by MAPKAP kinases
Tree Number: T4.9.128.1
database_cross_reference: NCI:C91643
database_cross_reference: NCI_PID:C91643

p38-alpha and p38-beta Signaling Pathway
type: Class
subclass of: p38 MAPK Signaling Pathway PID
PMOID: PMO:00015055
Subclass_of: p38 MAPK Signaling Pathway PID
Synonym: Signaling mediated by p38-alpha and p38-beta
Tree Number: T4.9.128.2
database_cross_reference: NCI:C91682
database_cross_reference: NCI_PID:C91682

p38-gamma and p38-delta Signaling Pathway
type: Class
subclass of: p38 MAPK Signaling Pathway PID
PMOID: PMO:00015056
Subclass_of: p38 MAPK Signaling Pathway PID
Synonym: Signaling mediated by p38-gamma and p38-delta
Tree Number: T4.9.128.3
database_cross_reference: NCI:C91683
database_cross_reference: NCI_PID:C91683

Regulation of p38-alpha and p38-beta Pathway
type: Class
subclass of: p38 MAPK Signaling Pathway PID
PMOID: PMO:00015057
Subclass_of: p38 MAPK Signaling Pathway PID
Synonym: Regulation of p38-alpha and p38-beta
Tree Number: T4.9.128.4
database_cross_reference: NCI:C91662
database_cross_reference: NCI_PID:C91662

Pain Repression Pathway
type: Class
subclass of: Signaling Pathway
definition: The molecular events that lead to the perception of pain are a key research field in medicine and drug discovery. The opioid receptors modulate pain signaling in response to endogenous peptide ligands and opiate drugs such as morphine. The kappa opioid receptor plays a key role in the profound analgesia of opiates and is activated by the endogenous peptide ligand dynorphin, encoded by the prodynorphin gene. Production of prodynorphin is transcriptionally regulated by a downstream regulatory element (DRE) in the prodynorphin gene. A transcription factor called DREAM (DRE antagonistic modulator) binds to the DRE and represses prodynorphin transcription when bound. DREAM binds calcium with 4 EF-hand motifs and the binding of DREAM to DNA is repressed in the presence of calcium. Many transcription factors are regulated by calcium indirectly through calcium sensitive kinases and phosphatases, but DREAM is unique to date in being a transcription factor that directly binds calcium and is regulated by calcium binding. DREAM may also regulate other genes such as c-fos. DREAM is expressed in spinal cord neurons in regions involved in pain signaling. The regulation of prodynorphin expression by DREAM also leads to the hypothesis that DREAM is involved in pain signaling. Transgenic mice lacking the DREAM gene were unusually pain insensitive and had elevated spinal levels of dynorphin and tonic activation of the kappa opioid receptor, supporting this hypothesis. Other functions of DREAM may exist such as regulation of presenilins and potassium channel activity in the heart. DREAM is also known as calsenilin and KChIP3 through its association with these other proteins. These processes were not affected in mice lacking the DREAM gene however. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015058
Subclass_of: Signaling Pathway
Synonym: Repression of Pain Sensation by the Transcriptional Regulator DREAM
Tree Number: T4.9.129
database_cross_reference: NCI:C39052
database_cross_reference: NCI_BioC:C39052

PDGF Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Platelet Derived Growth Factor (PDGF) plays a critical role in cellular proliferation and development. The biologically active form is a dimer formed from the A and B chains. PDGF is active to a differing degree depending on which dimer is formed (AA, AB, or BB). The PDGF Receptor (PDGFR) is also a dimer and can form from the combination of the alpha and beta chains in any order (alpha-alpha, alpha-beta, beta-beta). The PDGFR dimer is only formed after ligand binding so the alpha/beta composition of the receptor can be influenced by the form of PDGF that is present. Upon binding of ligand the PDGFR is tyrosine phosphorylated and leads to the phosphorylation of several other cellular proteins. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015059
Subclass_of: Signaling Pathway
Tree Number: T4.9.130
database_cross_reference: NCI:C39184
database_cross_reference: NCI_BioC:C39184

PDGFR-alpha Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015060
Subclass_of: Signaling Pathway
Synonym: Alpha-Type Platelet-Derived Growth Factor Receptor Signaling Pathway
Synonym: PDGFR-alpha signaling pathway
Tree Number: T4.9.131
database_cross_reference: GO:GO:0035790
database_cross_reference: NCI:C91647
database_cross_reference: NCI_PID:C91647

PDGFR-beta Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015061
Subclass_of: Signaling Pathway
Synonym: Beta-Type Platelet-Derived Growth Factor Receptor Signaling Pathway
Synonym: PDGF receptor-beta signaling pathway
Synonym: PDGFR-beta signaling pathway
Synonym: betaPDGF receptor signaling pathway
Synonym: platelet-derived growth factor receptor-beta signaling pathway
Synonym: platelet-derived growth factor receptor-beta signalling pathway
Tree Number: T4.9.132
database_cross_reference: GO:GO:0035791
database_cross_reference: NCI:C91648
database_cross_reference: NCI_PID:C91648

Pelp1 Estrogen Receptor Pathway
type: Class
subclass of: Signaling Pathway
definition: Proline-, glutamic acid-, leucine-rich protein 1 (Pelp1 or modulator of nongenomic activity of estrogen, MNAR) is a recently discovered transmitter of estrogen signals. The receptors for estrogen (ER), progestin (PR), androgen (AR) and others are steroid hormone receptors, which are part of a large family of ligand-inducible transcription factors. It has been established that estrogen has at least two courses of action termed classical or genomic and nongenomic. The classical activation cascade is well known. The nongenomic or nontranscriptional activation cascade for the estrogen receptor was determined based on the rapid response times observed for the activation of the MAPK cascade and other cell proliferation effects. The mechanism was believed to involve a membrane bound ER but attempts to isolate such a protein have not been successful. A second possibility would involve a scaffold protein that interacts with ER. Pelp1 appears to fit the second scenario. Pelp1 was first isolated as a coactivator of transcription for ER-alpha. It was observed that Pelp1 was expressed at levels 3-5 times normal in breast tumors. Several breast cancer cell lines have been shown to express Pelp1. Like many nuclear hormone receptors Pelp1 also interacts with Cbp and p300. More recently it has been demonstrated that Pelp1 mediates the interaction of ER and Src leading to the activation of the Mitogen Activated Protein Kinases Erk1 and Erk2. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015062
Subclass_of: Signaling Pathway
Synonym: Pelp1 Modulation of Estrogen Receptor Activity
Tree Number: T4.9.133
database_cross_reference: NCI:C39186
database_cross_reference: NCI_BioC:C39186

Phosphatidylinositol Signaling System Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015063
Subclass_of: Signaling Pathway
Synonym: Phosphatidylinositol Signaling System
Tree Number: T4.9.134
database_cross_reference: NCI:C38850
database_cross_reference: NCI_KEGG:C38850

Phospholipase C Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Phospholipase C comes in multiple forms and plays a key role in the signal transduction process for many receptors. Its main function is to hydrolyze phosphatidylinositol diphosphate into diacylglycerol (DG) and inositol triphosphate (IP3). DG is necessary for further activation of Protein Kinase C while IP3 leads to the release of intracellular calcium. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015064
Subclass_of: Signaling Pathway
Tree Number: T4.9.135
database_cross_reference: NCI:C39194
database_cross_reference: NCI_BioC:C39194

Phospholipase C-Epsilon Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Proposed model for b2-AR- and prostanoid-receptor-mediated PLC and calcium signaling. Receptors coupling to Gs stimulate AC, resulting in elevated cAMP levels and activation of Epac1. Epac1 then catalyses GTP-loading on Rap2B, which leads to PLC-e activation. The proposed pathway may involve additional signaling components to attain PLC stimulation. The action of cAMP seems to be independent of PKA; instead, the cAMP-activated Rap-GEF Epac seems to serve as a cAMP effector, inducing GTP loading and, hence, activation of Rap2B, which then leads to specific activation of PLC-e, which has been shown to interact with Rap GTPases. It is an attractive hypothesis, therefore, that the Rap-dependent PLC and calcium signaling pathway reported here is not restricted to Gs-and AC-coupled receptors, such as the b2-AR and the prostanoid receptor, but could be used by other receptors as well. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015065
Subclass_of: Signaling Pathway
Synonym: Phospholipase C-epsilon pathway
Tree Number: T4.9.136
database_cross_reference: NCI:C39193
database_cross_reference: NCI_BioC:C39193

Phospholipid Associated Cell Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Phospholipase C (PLC) d1 is a member of the PLC family that produces two second messengers, diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) by hydrolyzing the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). DAG in combination with Ca++ is necessary for further activation of Protein Kinase C, while IP3 diffuses into the cytoplasm and mediates the release of intracellular calcium. PLC d1 has a pleckstrin homology (PH) domain that binds to PIP2 in the membrane with an affinity of 1.7 mM. It has selectivity for PIP2 over other phosphatidylinositol lipids and provides a specific probe for activation of PIP2 metabolism to DG and IP3. Activation of PLC d1 results in its translocation from the membrane to the cytoplasm. PLC d1 activity is feedback-inhibited by IP3, which has an 8-fold higher affinity for PLC d1 than does PIP2. The members of the PLC family play a key role in the signal transduction cascade for many receptors. At basal Ca++ levels PLC d1 has been shown to be activated by the adrenoreceptor a1B, adrenoreceptor a1D, a-thromboxane receptor and oxytocin receptor. The G protein involved is the GTP-binding protein known as tissue transglutaminase (Gah or TGII). Gah is a bifunctional enzyme, having GTPase and transglutaminase (TGase) activity and is present in the plasma membrane, cytosol, and nucleus. Exchange of GDP to GTP by Gah is facilitated by activation of the receptors. However, a bimodal regulation of PLC d1 activity has been observed depending on Ca++ levels and occupancy of the guanine nucleotide binding site of Gah. In addition, the GTPase activating protein RhoGAP interacts with and stimulates PLC d1. The complex regulation of PLC d1 activity enables the protein to modulate intracellular signaling. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015066
Subclass_of: Signaling Pathway
Synonym: Phospholipase C d1 in phospholipid associated cell signaling
Tree Number: T4.9.137
database_cross_reference: NCI:C39192
database_cross_reference: NCI_BioC:C39192

Phospholipid Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Sphingosine-1-phosphate (S1P) is an example of a lipid messenger with both intracellular and extracellular functions. Intracellularly S1P regulates proliferation and survival; extracellularly S1P is a ligand for EDG1 (also known as S1P1). Activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine, increases cellular levels of S1P. Inhibitors of SPHK block formation of S1P and inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (PDGF) and PMA. In a study using endothelial cells it was demonstrated that S1P induces activation of alpha-v and B3 integrins via RhoA. S1P also activates Akt via Gi and PI3K. The activated Akt phosphorylates the Edg1 receptor on threonine 236 leading to the activation of Rac1 and subsequent signals leading to actin assembly, chemotaxis and lamellipodia formation. Edg1 stimulation also leads to the activation of the ERK signaling cascade resulting in anti-apoptotic reversal, proliferation and cell survival. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015067
Subclass_of: Signaling Pathway
Synonym: Phospholipids as signaling intermediaries
Tree Number: T4.9.138
database_cross_reference: NCI:C39055
database_cross_reference: NCI_BioC:C39055

Phototransduction Pathway
type: Class
subclass of: Signaling Pathway
definition: Phototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons by the photoreceptive pigments, the rhodopsins, which consist of a membrane embedded chromophore, 11-cis-retinal, and a G-protein-coupled receptor, opsin. The photon isomerizes 11-cis-retinal to all-trans-retinal which induces a structural change that activates the opsin. This triggers hydrolysis of cGMP by activating a transducin-phosphodiesterase 6 (PDE6) cascade, which results in closure of the cGMP-gated cation channels (CNG) in the plasma membrane and membrane hyperpolarization. The hyperpolarization of the membrane potential of the photoreceptor cell modulates the release of neurotransmitters to downstream cells. Recovery from light involves the deactivation of the light-activated intermediates: photolyzed rhodopsin is phosphorylated by rhodopsin kinase (RK) and subsequently capped off by arrestin; GTP-binding transducin alpha subunit deactivates through a process that is stimulated by RGS9.
PMOID: PMO:00015068
Subclass_of: Signaling Pathway
Synonym: Phototransduction
Tree Number: T4.9.139
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91805
database_cross_reference: NCI_KEGG:C91805

Plasma Membrane Estrogen Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015069
Subclass_of: Signaling Pathway
Synonym: Plasma membrane estrogen receptor signaling
Tree Number: T4.9.140
database_cross_reference: NCI:C91649
database_cross_reference: NCI_PID:C91649

PPAR Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
PMOID: PMO:00015070
Subclass_of: Signaling Pathway
Synonym: PPAR signaling pathway
Synonym: Peroxisome Proliferator-Activated Receptor Signaling Pathway
Synonym: peroxisome proliferator activated receptor signaling pathway
Synonym: peroxisome proliferator activated receptor signalling pathway
Synonym: peroxisome proliferator-activated receptor signaling pathway
Tree Number: T4.9.141
database_cross_reference: GO:GO:0035357
database_cross_reference: NCI:C91497
database_cross_reference: NCI_KEGG:C91497

Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015071
Subclass_of: Signaling Pathway
Synonym: Signaling events regulated by Ret tyrosine kinase
Tree Number: T4.9.142
database_cross_reference: NCI:C91681
database_cross_reference: NCI_PID:C91681

PTP4A Family Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015072
Subclass_of: Signaling Pathway
Synonym: PRL Signaling Pathway
Synonym: Signaling events mediated by PRL
Tree Number: T4.9.143
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91677
database_cross_reference: NCI_PID:C91677

PTPN1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015073
Subclass_of: Signaling Pathway
Synonym: PTP1B Signaling Pathway
Synonym: Signaling events mediated by PTP1B
Tree Number: T4.9.144
database_cross_reference: NCI:C91678
database_cross_reference: NCI_PID:C91678

Pyk2 and Map Kinase Pathway
type: Class
subclass of: Signaling Pathway
definition: This pathway is a compilation of Pyk2 effort cascades; in specific cell types the receptor and effectors will vary. Binding of a transmembrane receptor triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatives the JNK cascade, starting with PAK followed by MEKK1, SEK1, and JNK. JNK activation causes induction of c-Jun gene binding. Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38. The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015074
Subclass_of: Signaling Pathway
Synonym: Links between Pyk2 and Map Kinases
Tree Number: T4.9.145
database_cross_reference: NCI:C39206
database_cross_reference: NCI_BioC:C39206

Rac1 Cell Motility Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Rac-1 is a small G-protein in the Rho family that regulates cell motility in response to extracellular signals. Several changes in cytoskeletal structure and other aspects of cell structure are involved in cell motility. Rac-1 is activated by GEF factors, and repressed by GAPs. GEFs are guanine nucleotide exchange factors, including Trio and Vav. Sos-1 is involved in Ras signaling and also acts as a GEF for Rac to transduce signals between Ras and Rac. SWAP-70 is a Rac GEF that binds IP3 and transduces signals from tyrosine kinases to Rac to modulate the cytoskeleton and cause membrane ruffling. GAPs are GTPase- activating proteins. Rac stimulates the formation of actin-based structures such as filopodia and lamellipodia, while GAPs such as chimerin oppose the formation of these Rac dependent structures. Several different factors downstream of Rac act on cytoskeletal structure and other aspects of cell motility. Pak1 provides a direct link from Rac to cell motility through phosphorylation of the myosin light chain. Pak1 also phosphorylates and activates LIM kinase, which phosphorylates cofilin as one target. Cofilin stimulates actin depolymerization and changes in cell structure, and phosphorylation of cofilin by LIM kinase represses its activity. In neurons, Rac acts through the protein kinase cdk5 and p35 to phosphorylate and down regulate Pak1, increasing neuronal migration. Rac-1 also interacts with several other factors to regulate a variety of processes. Interaction of Por1 with Rac-1 is involved in membrane ruffling. WAVE is a member of the WASP family of proteins that regulate actin organization and that is involved in Rac signaling to cause membrane ruffling. Interaction of Rac-1 with MEKK1 integrates Rac signaling with pathways signaling through map kinases. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015075
Subclass_of: Signaling Pathway
Synonym: Rac 1 cell motility signaling pathway
Tree Number: T4.9.146
database_cross_reference: NCI:C39208
database_cross_reference: NCI_BioC:C39208

Ras Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Ras activates many signaling cascades. Here we illustrate some of the well-characterized cascades in a generic compilation of effector molecules. The effectors mediate Ras stimulation to a diverse set of cellular signals. Many of these signals are interpreted differently depending on the cell type or microenvironment receiving the stimulus. Not all of these effectors are activated in any given cell type. The primary method of activation is to promote the translocation of the molecule to the plasma membrane where additional interactions lead to the activation of the molecule. RalGDS is a Guanine Exchange Factor (GEF) for Ral but also has other independent functions. RalGDS activates RalA/B-related small GTPases. RalBP1 is a GTPase activating protein that leads to the inhibition of the Rac and CDC42 GTPases. Ral can also interact with phospholipase D1 (PLD1) that can also be activated by RhoA. Ras stimulation of the lipid kinase activity of PI3K occurs through an interaction with the p110 catalytic subunit. PI3K phosphorylates the D3 position of phosphatidylinositides. In this example Pip2 is converted to PIP3. PIP3 stimulates the AKT/PKB kinase and several of the Rac-GEFs such as Sos1 AND Vav. AKT activation inhibits apoptosis by inhibiting the actions of Bad, Caspase 9, and AFX. AKT further hinders apoptosis by phosphorylating the IkB repressor of NFkB. Stimulus of Rac causes, among other things, the activation of NFkB. Ras also stimulates the mitogen-activated kinases ERK1/2 via the Raf1 cascade. The Erk kinases translocate to the nucleus where they phosphorylate various transcription factors such as ELK1. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015076
Subclass_of: Signaling Pathway
Tree Number: T4.9.147
database_cross_reference: NCI:C39217
database_cross_reference: NCI_BioC:C39217

RB Checkpoint Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Cell cycle checkpoint controls at the G1 to S transition and the G2 to M transition prevent the cell cycle from progressing when DNA is damaged. The ATM protein kinase detects DNA damage and, in response to this, activates DNA repair factors and inhibits cell cycle progression. Two of the proteins that ATM phosphorylates in response to DNA damage are the tumor suppressor p53 and the checkpoint kinase chk1. In turn, the tumor suppressor p53 interacts with p21 to block the activity of cdk2 (cyclin dependent kinase 2) preventing passage from G1 to S phase and harmful replication of damaged DNA. One of the targets of cdk2 is the Rb gene product, another tumor suppressor. When dephosphorylated, Rb interacts with E2F transcription factors and prevents transcription of genes required for progression through the cell cycle. When phosphorylated by cell cycle dependent kinases like cdk2 and cdk4, Rb no longer interacts with E2F and the cell cycle proceeds through the G1-S checkpoint. DNA damage also regulates the G2-M phase transition by acting on the cell cycle regulator cdc2. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015077
Subclass_of: Signaling Pathway
Synonym: RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
Tree Number: T4.9.148
database_cross_reference: NCI:C39218
database_cross_reference: NCI_BioC:C39218

Reelin Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
definition: Reelin is an extracellular protein secreted by neurons. Reeler mice with a defective Reelin gene exhibit neuronal abnormalities in development. Mice that are heterozygous for the Reelin knockout have neuroanatomical and behavioral traits similar to those of schizophrenia patients, suggesting that mice with a deficiency in Reelin may provide a useful model for schizophrenia. Reelin protein may be involved in cognitive function in adults as well as playing a role in the developmental organization of neurons in the cortex. Multiple cell surface receptors transduce Reelin signaling into neurons. One class of Reelin receptor includes the VLDL receptor and the ApoER2. The intracellular adaptor Dab1 binds to the VLDL receptor and ApoER2 receptor through an NPxY motif and is involved in transmission of Reelin signals through these lipoprotein receptors. Mutation of the mDab1 gene in mice creates a phenotype identical to Reeler mice, supporting the role of this cytoplasmic factor in signaling downstream from Reelin. Another class of receptor for Reelin is the cadherin-related neuronal receptors, CNR receptors. Reelin signaling through several different CNR receptors activates the Fyn tyrosine kinases. Reelin stimulates phosphorylation of Dab1 and Dab1 appears to link Reelin signaling with tyrosine kinases. Disruption of the p35 and Cdk5 genes in mice indicates that cdk5 is also involved in the role of Reelin in neuronal development. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015078
Subclass_of: Signaling Pathway
Synonym: Reelin Signaling Pathway
Tree Number: T4.9.149
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39220
database_cross_reference: NCI_BioC:C39220

Reelin Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015079
Subclass_of: Signaling Pathway
Synonym: Reelin signaling pathway
Tree Number: T4.9.150
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91658
database_cross_reference: NCI_PID:C91658

Retinoic Acid Receptor Family-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015080
Subclass_of: Signaling Pathway
Synonym: Retinoic acid receptors-mediated signaling
Tree Number: T4.9.151
database_cross_reference: NCI:C91665
database_cross_reference: NCI_PID:C91665

RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway
type: Class
subclass of: Retinoic Acid Receptor Family-Mediated Signaling Pathway
PMOID: PMO:00015081
Subclass_of: Retinoic Acid Receptor Family-Mediated Signaling Pathway
Synonym: RXR and RAR heterodimerization with other nuclear receptor
Tree Number: T4.9.151.1
database_cross_reference: NCI:C91666
database_cross_reference: NCI_PID:C91666

Rho Cell Motility Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: RhoA is a small G-protein in the Rho family that regulates cell morphology via actin cytoskeleton reorganization in response to extracellular signals. The majority of RhoA activations are due to disruption of intramolecular autoinhibitory interactions. Changes in cytoskeletal structure and other aspects of cell structure are involved in cell morphology. RhoA is activated by GEF factors, and repressed by GAPs. GEFs are guanine nucleotide exchange factors. GAPs are GTPase-activating proteins. The RhoGAP ARHGAP1 also acts as a GAP for Rac and CDC42. Active RhoA increases the stability of actin-based structures such as stress fibers and focal adhesions. Several different factors downstream of RhoA act on cytoskeletal structures to affect stability of these structures. Rock1 provides a direct link from RhoA to cell morphology through phosphorylation of the myosin light chain. Rock1 also phosphorylates and activates LIM kinase, which phosphorylates cofilin. Cofilin stimulates actin depolymerization and changes in cell structure, and phosphorylation of cofilin by LIM kinase represses this activity. According to Nimnual et al. Rho activity is reduced as a result of Rac-induced redox-dependent inhibition. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015082
Subclass_of: Signaling Pathway
Synonym: Rho cell motility signaling pathway
Tree Number: T4.9.152
database_cross_reference: NCI:C39223
database_cross_reference: NCI_BioC:C39223

RIG-I-Like Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
PMOID: PMO:00015083
Subclass_of: Signaling Pathway
Synonym: RIG-I-like receptor signaling pathway
Tree Number: T4.9.153
database_cross_reference: NCI:C91507
database_cross_reference: NCI_KEGG:C91507

Rod Cell Visual Signal Transduction Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015084
Subclass_of: Signaling Pathway
Synonym: Visual signal transduction: Rods
Tree Number: T4.9.154
database_cross_reference: NCI:C91699
database_cross_reference: NCI_PID:C91699

SODD/TNFR1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The tumor necrosis factor (TNF) receptor superfamily contains several members with homologous cytoplasmic domains known as death domains (DD). The intracellular DD are important in initiating apoptosis and other signaling pathways following ligand binding by the receptors. In the absence of ligand, DD-containing receptors are maintained in an inactive state. TNFR1 contains a cytoplasmic DD required for signaling pathways associated with apoptosis and NF-kB activation. Jiang et al. identified a widely expressed 60 kDa protein, named SODD (silencer of death domains), associated with the DD of TNFR1 and DR3. Overexpression of SODD suppresses TNF-induced cell death and NF-kB activation demonstrating its role as a negative regulatory protein for these signaling pathways. TNF-induced receptor trimerization aggregates the DD of TNFR1 and recruits the adapter protein TRADD. This in turn promotes the recruitment of the DD-containing cytoplasmic proteins FADD, TRAF2, and RIP to form an active TNFR1 signaling complex. In contrast, SODD acts as a silencer of TNFR1 signaling and does not interact with TRADD, FADD, or RIP. It is associated with the DD of TNFR1 and maintains TNFR1 in an inactive, monomeric state. TNF-induced aggregation of TNFR1 promotes the disruption of the SODD-TNFR1 complex. SODD does not interact with the DD of other TNF receptor superfamily members such as Fas, DR4, DR5, or TNFR2. SODD association with TNFR1 may represent a general model for the prevention of spontaneous TNF signaling by other DD-containing receptors. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015085
Subclass_of: Signaling Pathway
Tree Number: T4.9.155
database_cross_reference: NCI:C39234
database_cross_reference: NCI_BioC:C39234

Sonic Hedgehog Pathway
type: Class
subclass of: Signaling Pathway
definition: Sonic Hedgehog (Shh) is one of a family of three secreted proteins, including Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh), that play distinct and crucial roles in development. The morphogenic signal Shh provides in the developing CNS induces proliferation of neuronal precursor cells in the developing cerebellum and other tissues. Proliferative signaling by Shh is involved in the development of cancer, including specific brain and skin cancers such as basal cell carcinomas, while activation of Shh signaling in neurons may also provide a means to induce neuronal regeneration. Mitogenic Shh signaling does not appear to involve Map kinase pathways, but may involve induction of Cyclin D1 expression to maintain Rb in the hyperphosphorylated state and allow progression through the G1 phase of the cell cycle. Activation of myc may be one mechanism by which Shh induces cell cycle progression. Activation of Shh proliferative signaling occurs through binding to a receptor complex including Patched (Ptc-1) and Smoothened, a G-protein coupled receptor. Patched is an integral membrane protein with twelve transmembrane domains that acts as an inhibitor of Smoothened activation. Patched has been classified as a tumor suppressor due to its inhibition of Smoothened and the presence of inactivated Ptc-1 mutations in some cancers. One possibility is that Ptc-1, which resembles transmembrane channels, may not directly associate with Smoothened but may repress Smoothened signaling by transporting an endogenous Smoothened inhibitor across the plasma membrane into the cytoplasm. Small non-peptide agonists and antagonists of the Shh pathway have been identified and appear to act at the level of the Smoothened receptor, providing pharmacological tools to study Shh signaling. The pathway downstream of the Smoothened receptor has remained somewhat unclear, but involves the Gli family of transcriptional activators, including Gli-1, Gli-2, and Gli-3, homologs of the drosophila gene cubitis i…
PMOID: PMO:00015086
Subclass_of: Signaling Pathway
Synonym: Sonic Hedgehog (Shh) Pathway
Tree Number: T4.9.156
database_cross_reference: NCI:C39231
database_cross_reference: NCI_BioC:C39231

Sphingosine 1-Phosphate Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015087
Subclass_of: Signaling Pathway
Synonym: S1P receptor signaling pathway
Synonym: S1P signaling pathway
Synonym: S1P-activated G-protein coupled receptor signaling pathway
Synonym: S1P-activated GPCR signaling pathway
Synonym: S1P-stimulated signal transduction pathway
Synonym: Sphingosine 1-phosphate (S1P) pathway
Synonym: sphingosine-1-phosphate signal transduction
Synonym: sphingosine-1-phosphate signaling pathway
Tree Number: T4.9.157
database_cross_reference: GO:GO:0003376
database_cross_reference: NCI:C91667
database_cross_reference: NCI_PID:C91667

Sphingosine 1-Phosphate Receptor 1 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
PMOID: PMO:00015088
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG1 Signaling Pathway
Synonym: S1P1 pathway
Tree Number: T4.9.157.1
database_cross_reference: NCI:C91668
database_cross_reference: NCI_PID:C91668

Sphingosine 1-Phosphate Receptor 2 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
PMOID: PMO:00015089
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG2 Signaling Pathway
Synonym: S1P2 pathway
Tree Number: T4.9.157.2
database_cross_reference: NCI:C91669
database_cross_reference: NCI_PID:C91669

Sphingosine 1-Phosphate Receptor 3 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
PMOID: PMO:00015090
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG3 Signaling Pathway
Synonym: S1P3 pathway
Tree Number: T4.9.157.3
database_cross_reference: NCI:C91670
database_cross_reference: NCI_PID:C91670

Sphingosine 1-Phosphate Receptor 4 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
PMOID: PMO:00015091
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG4 Signaling Pathway
Synonym: S1P4 pathway
Tree Number: T4.9.157.4
database_cross_reference: NCI:C91671
database_cross_reference: NCI_PID:C91671

Sphingosine 1-Phosphate Receptor 5 Signaling Pathway
type: Class
subclass of: Sphingosine 1-Phosphate Signaling Pathway
PMOID: PMO:00015092
Subclass_of: Sphingosine 1-Phosphate Signaling Pathway
Synonym: EDG5 Signaling Pathway
Synonym: S1P5 pathway
Tree Number: T4.9.157.5
database_cross_reference: NCI:C91672
database_cross_reference: NCI_PID:C91672

Sprouty Regulation of Tyrosine Kinase Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors, including EGF and FGF. One mechanism by which Sprouty proteins inhibit signaling is through binding to Grb-2, a signaling intermediary between the tyrosine kinase growth factors and the Ras/map kinase pathway. Binding of Sprouty to Grb-2 prevents Grb-2 and Sos-1 from interacting with downstream signaling factors that activate Ras and map kinases, including Ras, Raf-1, Mek1, Erk1/2, and downstream transcription factors. The action of Sprouty as an inhibitor of this pathway requires Sprouty phosphorylation and membrane localization at the site of the factors it interacts with. The inhibition of growth factor signaling by Sprouty is specific to the Ras pathway since the PI3 Kinase pathway responsible for cell survival signals from growth factor receptors is not inhibited by Sprouty. Tyrosine kinase activity of growth factor receptors is also not affected. The mechanism by which Sprouty inhibits Ras activation may be by blocking the nucleotide exchange activity of Sos. Sprouty expression is induced by growth factor receptor activation of Ras signaling, provided a self-regulatory feedback inhibition mechanism that regulates growth factor signaling through Ras. In addition to blocking the Ras pathway, Sprouty also induces protein tyrosine phosphatase 1B activity. Activation of PTP1B by Sprouty is responsible for the inhibition of cellular migration that Sprouty causes, but is not involved in regulation of cellular proliferation. While blocking receptor tyrosine kinase signaling, at least one member of the Sprouty family, Sprouty-2, also acts by one mechanism to stimulate EGF receptor signaling. Cbl targets the EGF receptor for tagging with ubiquitin and proteolytic destruction. Sprouty-2 binds to Cbl and blocks the ubiquitination and destruction of the EGF receptor, increasing EGF signaling. (This definition may be outdated…
PMOID: PMO:00015093
Subclass_of: Signaling Pathway
Synonym: Sprouty regulation of tyrosine kinase signals
Tree Number: T4.9.158
database_cross_reference: NCI:C39236
database_cross_reference: NCI_BioC:C39236

Stat3 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: STATs, Signal Transducers and Activators of Transcription, are transcription factors that are phosphorylated by JAK kinases in response to cytokine activation to dimerize and move into the nucleus to activate transcription of cytokine-responsive genes. There are at least 3 JAK kinases and at least six STATs, with different cytokines inducing different patterns of JAK and STAT activation. Cytokines that activate STAT3 include growth hormone, IL-6 family cytokines, and G-CSF. STAT3, as well as STAT5, induces progression through the cell cycle, prevents apoptosis, and may be associated with cancer development in some cases. STAT3 plays an important role in normal development, particularly hematopoiesis. The importance of STAT3 is underscored by the failure of mice lacking STAT3 to survive embryogenesis. Crosstalk from pathways other than JAK kinases also leads to phosphorylation and activation of STAT3 as indicated by a role of mTOR (mammalian target of rapamycin, or p70 S6 kinase) and mitogen-activated protein kinase (MAP kinase) pathways in STAT3 activation and signaling. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015094
Subclass_of: Signaling Pathway
Tree Number: T4.9.159
database_cross_reference: NCI:C39238
database_cross_reference: NCI_BioC:C39238

Stress Fiber Formation Pathway
type: Class
subclass of: Signaling Pathway
definition: The A-kinase anchor protein 13 (AKAP13, also known as AKAP-LBC) is one of a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP13 is a splice variant of the oncogene Lbc. Alternative splicing of the AKAP13 gene results in at least 3 transcript variants encoding different isoforms containing a Dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. These splice variants contain a fragment that was originally identified as Ht31 (See Carr et al 1991) which acts as a scaffolding protein to regulate the Rho signaling pathway and as protein kinase A-anchoring protein creating a coordination of these two signaling pathways. Diviani et al. found that in HEK293 cells LPA induced stimulation preferentially activates AKAP13 via G-alpha12. As yet targets for the anchored PKA have not been identified. AKAP13 and Rho do not appear to be phosphorylated by PKA. Diviani et al also found that the Lbc oncogene and protooncogene splice variant show higher activation and stress fiber localization. This appears to be a result of the presence of N terminal inhibitory sequences. A similar model of regulation has been proposed for Dbl and Vav. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015095
Subclass_of: Signaling Pathway
Synonym: Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation
Tree Number: T4.9.160
database_cross_reference: NCI:C38978
database_cross_reference: NCI_BioC:C38978

Syndecan-Mediated Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015096
Subclass_of: Signaling Pathway
Synonym: Proteogylcan syndecan-mediated signaling events
Tree Number: T4.9.161
database_cross_reference: NCI:C91655
database_cross_reference: NCI_PID:C91655

Syndecan-1-Mediated Signaling Pathway
type: Class
subclass of: Syndecan-Mediated Signaling Pathway
PMOID: PMO:00015097
Subclass_of: Syndecan-Mediated Signaling Pathway
Synonym: Syndecan-1-mediated signaling events
Tree Number: T4.9.161.1
database_cross_reference: NCI:C91686
database_cross_reference: NCI_PID:C91686

Syndecan-2-Mediated Signaling Pathway
type: Class
subclass of: Syndecan-Mediated Signaling Pathway
PMOID: PMO:00015098
Subclass_of: Syndecan-Mediated Signaling Pathway
Synonym: Syndecan-2-mediated signaling events
Tree Number: T4.9.161.2
database_cross_reference: NCI:C91687
database_cross_reference: NCI_PID:C91687

Syndecan-3-Mediated Signaling Pathway
type: Class
subclass of: Syndecan-Mediated Signaling Pathway
PMOID: PMO:00015099
Subclass_of: Syndecan-Mediated Signaling Pathway
Synonym: Syndecan-3-mediated signaling events
Tree Number: T4.9.161.3
database_cross_reference: NCI:C91688
database_cross_reference: NCI_PID:C91688

Syndecan-4-Mediated Signaling Pathway
type: Class
subclass of: Syndecan-Mediated Signaling Pathway
PMOID: PMO:00015100
Subclass_of: Syndecan-Mediated Signaling Pathway
Synonym: Syndecan-4-mediated signaling events
Tree Number: T4.9.161.4
database_cross_reference: NCI:C91689
database_cross_reference: NCI_PID:C91689

Taste Transduction Pathway
type: Class
subclass of: Signaling Pathway
definition: All taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na+ through the amiloride-sensitive Na+ channel (ENaC). Acids depolarize taste cells by a variety of mechanisms, including influx of protons (H+) through ENaC and a proton-gated cation channel (MDEG). Two putative umami receptors have been identified: a truncated variant of the metabotropic glutamate receptor mGluR4 and the heterodimer, T1R1 + T1R3. Umami receptors are coupled to a signaling pathway involving activation of PLCbeta2, production of IP3 and diacylglycerol, release of Ca2+ from intracellular stores and activation of a transient receptor potential channel, TRPM5. Bitter compounds, such as denatonium and PROP, activate particular T2R/TRB isoforms, which activate gustducin heterotrimers. Activated alpha-gustducin stimulates PDE to hydrolyze cAMP, whereas betagamma subunits activate PLCbeta2 to generate IP3, which leads to release of Ca2+ from internal stores. Artificial sweeteners activate GPCRs (T1R heterodimers) apparently linked via PLC to IP3 production and release of Ca2+ from intracellular stores. Sugars apparently activate GPCRs linked via AC to cAMP production which, in turn, may inhibit basolateral K+ channels through phosphorylation by cAMP-activated protein kinase A (PKA).
PMOID: PMO:00015101
Subclass_of: Signaling Pathway
Synonym: Taste transduction
Tree Number: T4.9.162
database_cross_reference: NCI:C91453
database_cross_reference: NCI_KEGG:C91453

TGF Beta Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
definition: TGF-beta regulates growth and proliferation of cells, blocking growth of many cell types. The TGF-beta receptor includes type 1 and type 2 subunits that are serine-threonine kinases and that signal through the SMAD family of transcriptional regulators. Defects in TGF-beta signaling, including mutation in SMADs, have been associated with cancer in humans. Prior to activation, receptor regulated SMADs are anchored to the cell membrane by factors like SARA (SMAD Anchor for Receptor Activation) that brings the SMADs into proximity of the TGF receptor kinases. Binding of TGF induces phosphorylation and activation of the TGF-beta R1 receptor by the TGF-beta R2 receptor. The activated TGF-beta R1 phosphorylates SMAD2 and SMAD3, which bind to the SMAD4 mediator to move into the nucleus and form complexes that regulate transcription. SMADs regulate transcription in several ways, including binding to DNA, interacting with other transcription factors, and interacting with transcription corepressors and coactivators like p300 and CBP. SMAD-7 represses signaling by other SMADs to down-regulate the system. Other signaling pathways, like the MAP kinase-ERK cascade activated by TGF-beta signaling, modulate SMAD activation. SnoN also regulates TGF-beta signaling, by binding to SMADs to block transcriptional activation. TGF-beta signaling causes degradation of SnoN, releasing SMADs to regulate transcription, and also activates expression of SnoN, to down-regulate SMAD signaling at later times. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015102
Subclass_of: Signaling Pathway
Synonym: TGF beta signaling pathway
Tree Number: T4.9.163
database_cross_reference: NCI:C39251
database_cross_reference: NCI_BioC:C39251

TGF-Beta Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015103
Subclass_of: Signaling Pathway
Synonym: TGF-beta receptor signaling
Synonym: TGF-beta receptor signaling pathway
Synonym: TGF-beta receptor signalling pathway
Synonym: TGFbeta receptor signaling pathway
Synonym: TGFbeta receptor signalling pathway
Synonym: Tumor Growth Factor-Beta Receptor Signaling Pathway
Synonym: transforming growth factor beta receptor signaling pathway
Synonym: transforming growth factor beta receptor signalling pathway
Tree Number: T4.9.164
database_cross_reference: GO:GO:0007179
database_cross_reference: NCI:C91690
database_cross_reference: NCI_PID:C91690

TGF-beta Signaling Pathway KEGG
type: Class
subclass of: Signaling Pathway
definition: The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads (R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
PMOID: PMO:00015104
Subclass_of: Signaling Pathway
Synonym: TGF-beta signaling pathway
Tree Number: T4.9.165
database_cross_reference: NCI:C91522
database_cross_reference: NCI_KEGG:C91522

Thrombin/Protease-Activated Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Thrombin is an extracellular protease that is involved in the clotting of blood and inflammation through its action on platelets and endothelial cells in the vasculature and that plays a role in thrombosis and myocardial infarction. The protease activated receptors PAR1 and PAR4 are cellular targets of thrombin signaling and members of the G-protein coupled receptor gene family. Both of these receptors are cleaved in their N-terminus by thrombin, unmasking a portion of the receptor sequence that acts itself as a tethered peptide ligand that activates the receptor. The tethered ligand that activates PAR1 is SFLLRN and the tethered ligand that activates PAR4 is GYPGQV. Other members of the family include PAR2 which is activated by trypsin rather than thrombin and PAR3 which seems to play a role in the activation of other PARs but does not itself transduce a signal directly. Addition of peptide agonist exogenously in solution can also activate PAR1, PAR2 and PAR4. PAR1 activation may be involved in the dilation of arteries during inflammation through the action of thrombin on endothelial cells and in platelet activation by thrombin during clotting. PAR1 and PAR2 activation cause bronchodilation in airway and may protect against asthma. PAR 4 activation by thrombin activates platelets during clotting and mice lacking PAR4 have impaired clotting and platelets that do not respond to thrombin signaling. The action of thrombin on PAR1 and PAR4 on platelets and endothelial cells may also contribute to vascular permeability and inflammation. Activated PARs appear to couple primarily through Gq-mediated stimulation of inositol phosphate metabolism and intracellular calcium levels to activate platelets. PAR1 and PAR4 also appear to couple to multiple G-proteins and transduce signals through more than one G-protein mediated pathway in some circumstances. Signaling by PAR1 and PAR4 through Galpha12 pathways couples to Rho signaling and changes in cytoskeletal structure and cell s…
PMOID: PMO:00015105
Subclass_of: Signaling Pathway
Synonym: Thrombin signaling and protease-activated receptors
Tree Number: T4.9.166
database_cross_reference: NCI:C39278
database_cross_reference: NCI_BioC:C39278

Thromboxane A2 Receptor Family Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015106
Subclass_of: Signaling Pathway
Synonym: Thromboxane A2 receptor signaling
Tree Number: T4.9.167
database_cross_reference: NCI:C91691
database_cross_reference: NCI_PID:C91691

TNF Receptor Family Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015107
Subclass_of: Signaling Pathway
Synonym: TNF receptor signaling pathway
Synonym: Tumor Necrosis Factor Receptor Signaling Pathway
Tree Number: T4.9.168
database_cross_reference: NCI:C91692
database_cross_reference: NCI_PID:C91692

TNF Stress Related Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: TNF acts on several different signaling pathways through two cell surface receptors, TNFR1 and TNFR2 to regulate apoptotic pathways, NF-kB activation of inflammation, and activate stress-activated protein kinases (SAPKs). Interaction of TNFR1 with TRADD leads to activation of NF-kB and apoptosis pathways, while interaction with TRAF2 has generally been thought to be involved in stress kinase and NF-kB activation but is not required for TNF to induce apoptosis. Activation of NF-kB is mediated by TRAF2 through the NIK kinase and also by RIP but the observation that TNF activates NF-kB in mice lacking TRAF2 indicates that TRAF-2 does not play an essential role in this process. Stress-activated protein kinases, also called JNKs, are a family of map kinases activated by cellular stress and inflammatory signals. Binding of TNF to the TNFR1 receptor activates the germinal center kinase (GCK) through the TNF adaptor Traf2, activating the map kinase MEKK1. Both GCK and MEKK1 interact with Traf2, and GCK is required for MEKK1 activation by TNF, but GCK kinase activity does not appear to be required for MEKK1 activation. Instead, GCK activates MEKK1 by causing MEKK1 oligomerization and autophosphorylation. Tank increases the affinity of Traf2 for GCK to increase Map kinase activation by TNF. Once activated, MEKK1 stands at the top of a map kinase pathway leading to transcriptional regulation, including JNK phosphorylation of c-Jun to stimulate transcriptional activation by AP-1, a heterodimer of c-jun and fos or ATF proteins. The activation of the p38 Map kinase also contributes to AP-1 activation leading to the transcriptional activation of many stress and growth related genes. RIP has been suggested as a component of the p38 pathway in addition to playing a role in NF-kB activation. MEKK1 knockout mice support the role of MEKK1 in JNK activation in some cells but did not support MEKK1 dependent activation of NF-kB. Alternative redundant mechanisms may obscure the role of MEK…
PMOID: PMO:00015108
Subclass_of: Signaling Pathway
Synonym: TNF/Stress Related Signaling
Tree Number: T4.9.169
database_cross_reference: NCI:C39241
database_cross_reference: NCI_BioC:C39241

TNFR1 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: TNFR1 (p55, CD120a) is the receptor for TNF-alpha and also will bind TNF-beta. Upon binding TNF-alpha a TNFR1+ cell is triggered to undergo apoptosis. This critical regulatory process is accomplished by activating the proteolytic caspase cascade that results in the degradation of many critical cellular proteins. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015109
Subclass_of: Signaling Pathway
Tree Number: T4.9.170
database_cross_reference: NCI:C39254
database_cross_reference: NCI_BioC:C39254

TNFR2 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: TNFR2 is the receptor for the 171 amino acid 19 kD TNF-beta (a.k.a. lymphotoxin). TNF-beta is produced by activated lymphocytes and can be cytotoxic to many tumor and other cells. In neutrophils, endothelial cells and osteoclasts TNF-beta can lead to activation while in many other cell types it can lead to increased expression of MHC and adhesion molecules. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015110
Subclass_of: Signaling Pathway
Tree Number: T4.9.171
database_cross_reference: NCI:C39255
database_cross_reference: NCI_BioC:C39255

Toll-Like Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-kappa B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-kappa B and MAPK.
PMOID: PMO:00015111
Subclass_of: Signaling Pathway
Synonym: TLR signaling pathway
Synonym: Toll-like receptor signaling pathway
Synonym: toll-like receptor signaling pathway
Synonym: toll-like receptor signalling pathway
Tree Number: T4.9.172
database_cross_reference: GO:GO:0002224
database_cross_reference: NCI:C91505
database_cross_reference: NCI_KEGG:C91505

TPO Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several major pathways including MAPK (ERK and JNK), Protein Kinase C, and JAK/Stat. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015112
Subclass_of: Signaling Pathway
Tree Number: T4.9.173
database_cross_reference: NCI:C39258
database_cross_reference: NCI_BioC:C39258

TRAIL Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015113
Subclass_of: Signaling Pathway
Synonym: TRAIL signaling pathway
Tree Number: T4.9.174
database_cross_reference: NCI:C91693
database_cross_reference: NCI_PID:C91693

Trka Receptor Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine kinase receptors that also includes TrkB and TrkC. Some NGF responses are also mediated or modified by p75LNTR, a low affinity neurotrophin receptor. Binding of NGF to TrkA stimulates neuronal survival, and also proliferation. Pathways coupled to these responses are linked to TrkA through association of signaling factors with specific amino acids in the TrkA cytoplasmic domain. Cell survival through inhibition of apoptosis is signaled through activation of PI3-kinase and AKT. Ras-mediated signaling and phospholipase C both activate the MAP kinase pathway to stimulate proliferation. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015114
Subclass_of: Signaling Pathway
Tree Number: T4.9.175
database_cross_reference: NCI:C39259
database_cross_reference: NCI_BioC:C39259

Tubby Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: The tubby gene product is expressed in the brain and has been implicated by mouse genetics in obesity and other disorders such as blindness. Structural analysis predicts that this gene acts as a transcription factor, binding to DNA to regulate gene expression. More recently, it was reported that tubby binds to phosphoinositides in the plasma membrane, helping to localize this factor in the membrane region in the absence of pathway activation. Tubby also interacts with Gq-alpha g-protein subunits, localizing tubby to regions of g-protein activation. Activation of phosphatase C activity and hydrolysis of membrane phosphoinositides leads to release of tubby from the plasma membrane, allowing tubby to enter the nucleus to bind DNA and regulate transcription. Some G-protein coupled receptors such as 5-HT2c may signal in part through tubby in addition to calcium-mediated pathways and protein-kinase signaling pathways. The identity of genes regulated by tubby and the mechanism by which tubby affects obesity remain to be explored. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015115
Subclass_of: Signaling Pathway
Synonym: G-Protein Signaling Through Tubby Proteins
Tree Number: T4.9.176
database_cross_reference: NCI:C39261
database_cross_reference: NCI_BioC:C39261

VEGF Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma-PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3'-kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
PMOID: PMO:00015116
Subclass_of: Signaling Pathway
Synonym: VEGF signaling pathway
Tree Number: T4.9.177
database_cross_reference: NCI:C91524
database_cross_reference: NCI_KEGG:C91524

VEGFR1 and VEGFR2 Signaling
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015117
Subclass_of: Signaling Pathway
Synonym: Signaling events mediated by VEGFR1 and VEGFR2
Tree Number: T4.9.178
database_cross_reference: NCI:C91680
database_cross_reference: NCI_PID:C91680

VEGFR1 Signaling Pathway
type: Class
subclass of: VEGFR1 and VEGFR2 Signaling
PMOID: PMO:00015118
Subclass_of: VEGFR1 and VEGFR2 Signaling
Synonym: FLT1 Signaling Pathway
Synonym: FLT1 signaling pathway
Synonym: VEGFR-1 signaling pathway
Synonym: VEGFR1 signaling pathway
Synonym: VEGFR1 specific signals
Synonym: Vascular Endothelial Growth Factor Receptor 1 Signaling Pathway
Synonym: vascular endothelial growth factor receptor-1 signaling pathway
Tree Number: T4.9.178.1
database_cross_reference: GO:GO:0036323
database_cross_reference: NCI:C91696
database_cross_reference: NCI_PID:C91696

VEGFR3 Lymphatic Signaling Pathway
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015119
Subclass_of: Signaling Pathway
Synonym: FLT4 Signaling Pathway
Synonym: FLT4 signaling pathway
Synonym: VEGFR-3 signaling pathway
Synonym: VEGFR3 signaling in lymphatic endothelium
Synonym: VEGFR3 signaling pathway
Synonym: Vascular Endothelial Growth Factor Receptor 3 Signaling Pathway
Synonym: vascular endothelial growth factor receptor-3 signaling pathway
Tree Number: T4.9.179
database_cross_reference: GO:GO:0036325
database_cross_reference: NCI:C91697
database_cross_reference: NCI_PID:C91697

Visual Signal Transduction Pathway
type: Class
subclass of: Signaling Pathway
definition: The signal transduction cascade responsible for sensing light in vertebrates is one of the best studied signal transduction processes, and is initiated by rhodopsin in rod cells, a member of the G-protein coupled receptor gene family. Rhodopsin remains the only GPCR whose structure has been resolved at high resolution. Rhodopsin in the discs of rod cells contains a bound 11-cis retinal chromophore, a small molecule derived from Vitamin A that acts as the light sensitive portion of the receptor molecule, absorbing light to initiate the signal transduction cascade. When light strikes 11-cis retinal and is absorbed, it isomerizes to all-trans retinal, changing the shape of the molecule and the receptor it is bound to. This change in rhodopsin's shape alters its interaction with transducin, the member of the G-protein gene family that is specific in its role in visual signal transduction. Activation of transducin causes its alpha subunit to dissociate from the trimer and exchange bound GDP for GTP, activating in turn a membrane-bound cyclic-GMP specific phosphodiesterase that hydrolyzes cGMP. In the resting rod cell, high levels of cGMP associate with a cyclic-GMP gated sodium channel in the plasma membrane, keeping the channels open and the membrane of the resting rod cells depolarized. This is distinct from synaptic generation of action potentials, in which stimulation induces opening of sodium channels and depolarization. When cGMP gated channels in rod cells open, both sodium and calcium ions enter the cell, hyperpolarizing the membrane and initiating the electrochemical impulse responsible for conveying the signal from the sensory neuron to the CNS. The rod cell in the resting state releases high levels of the inhibitory neurotransmitter glutamate, while the release of glutamate is repressed by the hyperpolarization in the presence of light to trigger a downstream action potential by ganglion cells that convey signals to the brain. The calcium which enters the cell…
PMOID: PMO:00015120
Subclass_of: Signaling Pathway
Synonym: Visual Signal Transduction
Tree Number: T4.9.180
database_cross_reference: NCI:C39222
database_cross_reference: NCI_BioC:C39222

WNT Signaling Pathway BioCarta
type: Class
subclass of: Signaling Pathway
definition: Wnt family members are secreted glycoproteins that bind to cell surface receptors such as Frizzled. Wnt members can play a role in the expression of many genes by interacting with multiple disparate signaling pathways. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015121
Subclass_of: Signaling Pathway
Synonym: Pathway, Wnt
Synonym: Pathway, Wnt Signaling
Synonym: Pathways, Wnt
Synonym: Pathways, Wnt Signaling
Synonym: Signaling Pathway, Wnt
Synonym: Signaling Pathways, Wnt
Synonym: WNT Signaling Pathway
Synonym: Wg signaling pathway
Synonym: Wg signalling pathway
Synonym: Wingless signaling pathway
Tree Number: T4.9.181
database_cross_reference: GO:GO:0016055
database_cross_reference: MSH:D060449
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C39270
database_cross_reference: NCI_BioC:C39270

Wnt Signaling Pathway KEGG
type: Class
subclass of: Signaling Pathway
definition: Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
PMOID: PMO:00015122
Subclass_of: Signaling Pathway
Synonym: Wnt signaling pathway
Tree Number: T4.9.182
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91531
database_cross_reference: NCI_KEGG:C91531

Wnt Signaling Pathway PID
type: Class
subclass of: Signaling Pathway
PMOID: PMO:00015123
Subclass_of: Signaling Pathway
Synonym: Wnt signaling network
Tree Number: T4.9.183
database_cross_reference: NCI:C91555
database_cross_reference: NCI_PID:C91555

Canonical Wnt Signaling Pathway
type: Class
subclass of: Wnt Signaling Pathway PID
PMOID: PMO:00015124
Subclass_of: Wnt Signaling Pathway PID
Synonym: Canonical Wnt signaling pathway
Synonym: Wnt receptor signaling pathway through beta-catenin
Synonym: Wnt receptor signaling pathway via beta-catenin
Synonym: Wnt receptor signalling pathway through beta-catenin
Synonym: canonical Wnt receptor signaling pathway
Synonym: canonical Wnt signaling pathway
Synonym: canonical Wnt-activated signaling pathway
Tree Number: T4.9.183.1
database_cross_reference: GO:GO:0060070
database_cross_reference: NCI:C91559
database_cross_reference: NCI_PID:C91559

Noncanonical Wnt Signaling Pathway
type: Class
subclass of: Wnt Signaling Pathway PID
PMOID: PMO:00015125
Subclass_of: Wnt Signaling Pathway PID
Synonym: Noncanonical Wnt signaling pathway
Tree Number: T4.9.183.2
database_cross_reference: NCI:C91639
database_cross_reference: NCI_PID:C91639

Presenilin Action in Notch and Wnt Signaling Pathways
type: Class
subclass of: Wnt Signaling Pathway PID
PMOID: PMO:00015126
Subclass_of: Wnt Signaling Pathway PID
Synonym: Presenilin action in Notch and Wnt signaling
Tree Number: T4.9.183.3
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C91654
database_cross_reference: NCI_PID:C91654

Wnt/LRP6 Signaling Pathway
type: Class
subclass of: Signaling Pathway
definition: Wnt glycoproteins play a role in diverse processes during embryonic patterning in metazoa through interaction with frizzled-type seven-transmembrane-domain receptors (Frz) to stabilize b-catenin. LDL-receptor-related protein 6 (LRP6), a Wnt co-receptor, is required for this interaction. Dikkopf (dkk) proteins are both positive and negative modulators of this signaling. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015127
Subclass_of: Signaling Pathway
Synonym: Wnt/LRP6 Signaling
Tree Number: T4.9.184
database_cross_reference: NCI:C39269
database_cross_reference: NCI_BioC:C39269

Wound Repair Pathway
type: Class
subclass of: Signaling Pathway
definition: This pathway illustrates the opposing effects that Proepithelin (PEPI) and the elastase digest fragments, the epithelins (EPIa-g), have on epithelial growth and neutrophil activation. PEPI (also known as progranulin, PC-cell derived growth factor, and acrogranin) is comprised of seven full and one half EPI motif separated by a linker. NMR studies indicate that EPIs are compact globular structures leading to the current suggestion of a string of beads. The epithelins are highly homologous 6kDa peptides with significant conservation in plants, insects, worms and mammals. The EPIs stimulate epithelial cell secretion of IL-8, which in turn stimulates neutrophils to secrete elastase. PEPI also inhibits the inhibition of secretory leukocyte protease inhibitor (SLPI) and stimulates the growth of epithelial cells leading to wound closure. SLPI is secreted by epithelial cell, neutrophils and macrophages. SLPI inhibits elastase and cathepsinG and the inhibition of SLPI from free radicals produced by neutrophils in the blood stream as part of the balance between wound repair and wound cleaning. SLPI binds to PEPI and prevents elastase from cleaving the various linker regions between the EPIs. SLPI also binds and blocks the protease activities of elastase. Unchecked elastase leads to impaired wound healing. In summary PEPI and SLPI, normally prevalent epithelial cells, protect the epithelia from roving neutrophils. Injury causes a reduction in SLPI leading to the cleavage of PEPI into the individual EPIs. The individual EPIs activate the neutrophils and generate the wound cleaning response. As the level of SLPI returns the amount of PEPI is restored and the switch from inflammation to repair occurs. (This definition may be outdated - see the DesignNote.)
PMOID: PMO:00015128
Subclass_of: Signaling Pathway
Synonym: Proepithelin Conversion to Epithelin and Wound Repair Control
Tree Number: T4.9.185
database_cross_reference: NCI:C39187
database_cross_reference: NCI_BioC:C39187

Biologic Function
type: Class
subclass of: Thing
PMOID: PMO:00015129
Subclass_of: owl:Thing
Tree Number: T5

Physiologic Function
type: Class
subclass of: Biologic Function
PMOID: PMO:00015130
Subclass_of: Biologic Function
Tree Number: T5.1

Organism Function
type: Class
subclass of: Physiologic Function
PMOID: PMO:00015131
Subclass_of: Physiologic Function
Tree Number: T5.1.1

Organ or Tissue Function
type: Class
subclass of: Physiologic Function
PMOID: PMO:00015132
Subclass_of: Physiologic Function
Tree Number: T5.1.2

Cell Function
type: Class
subclass of: Physiologic Function
PMOID: PMO:00015133
Subclass_of: Physiologic Function
Synonym: CELL PHYSIOL
Synonym: Cell Physiological Phenomena
Synonym: Cell Physiological Phenomenon
Synonym: Cell Physiology
Synonym: Cell Process
Synonym: Cell physiology
Synonym: Cellular Function
Synonym: Cellular Physiology
Synonym: Cellular Process
Synonym: PHYSIOL CELL
Tree Number: T5.1.3
database_cross_reference: AOD:0000002339
database_cross_reference: CHV:0000002597
database_cross_reference: LCH_NW:sh85021662
database_cross_reference: MSH:D002468
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C16405
database_cross_reference: NCI:C17710
database_cross_reference: NCI:C20480

Molecular Function
type: Class
subclass of: Physiologic Function
PMOID: PMO:00015134
Subclass_of: Physiologic Function
Synonym: molecular function
Synonym: molecular_function
Tree Number: T5.1.4
database_cross_reference: GO:GO:0003674

Genetic Function
type: Class
subclass of: Molecular Function
PMOID: PMO:00015135
Subclass_of: Molecular Function
Tree Number: T5.1.4.1

Pathologic Function
type: Class
subclass of: Biologic Function
PMOID: PMO:00015136
Subclass_of: Biologic Function
Tree Number: T5.2

Cell or Molecular Dysfunction
type: Class
subclass of: Pathologic Function
PMOID: PMO:00015140
Subclass_of: Pathologic Function
Tree Number: T5.2.2

Chemical and Drug
type: Class
subclass of: Thing
PMOID: PMO:00015141
Subclass_of: owl:Thing
Tree Number: T6

Inorganic Chemicals
type: Class
subclass of: Chemical and Drug
PMOID: PMO:00015142
Subclass_of: Chemical and Drug
Synonym: Chemicals, Inorganic
Synonym: Inorganic Chemical
Synonym: Inorganic Chemicals [Chemical/Ingredient]
Synonym: Inorganic chemical
Synonym: Inorganic chemical (substance)
Synonym: Inorganic chemical compound
Synonym: Inorganic chemical compound, NOS
Synonym: Inorganic chemical, NOS
Synonym: Inorganic compound
Synonym: Inorganic compounds
Tree Number: T6.1
database_cross_reference: AOD:0000019569
database_cross_reference: CHV:0000006749
database_cross_reference: LCH_NW:sh86005967
database_cross_reference: MSH:D007287
database_cross_reference: NCI:C579
database_cross_reference: NDFRT:N0000008257
database_cross_reference: RCD:Xa4Hs
database_cross_reference: SNM:E-5010
database_cross_reference: SNM:U000129
database_cross_reference: SNMI:C-10090
database_cross_reference: SNOMEDCT_US:58295004

Acids
type: Class
subclass of: Inorganic Chemicals
PMOID: PMO:00015143
Subclass_of: Inorganic Chemicals
Synonym: ACID
Synonym: Acid
Synonym: Acid (substance)
Synonym: Acid, NOS
Synonym: Acidic
Synonym: Acids [Chemical/Ingredient]
Synonym: acid
Synonym: acid substances
Synonym: acidity
Synonym: acids
Tree Number: T6.1.1
database_cross_reference: AOD:0000000749
database_cross_reference: CCPSS:0034137
database_cross_reference: CHV:0000000638
database_cross_reference: CSP:0030-0942
database_cross_reference: LCH:U000037
database_cross_reference: LCH_NW:sh85000532
database_cross_reference: LNC:LP20964-0
database_cross_reference: LNC:LP28790-1
database_cross_reference: MEDCIN:250653
database_cross_reference: MSH:D000143
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C48057
database_cross_reference: NCI_NCI-GLOSS:CDR0000642987
database_cross_reference: NCI_NCI-GLOSS:CDR0000642991
database_cross_reference: NDFRT:N0000007626
database_cross_reference: PSY:00550
database_cross_reference: RCD:X794A
database_cross_reference: SNM:E-5002
database_cross_reference: SNMI:C-10040
database_cross_reference: SNOMEDCT_US:34957004

Acids, Noncarboxylic
type: Class
subclass of: Acids
PMOID: PMO:00015144
Subclass_of: Acids
Synonym: Acids, Noncarboxylic [Chemical/Ingredient]
Synonym: Noncarboxylic Acids
Tree Number: T6.1.1.1
database_cross_reference: MSH:D000148
database_cross_reference: NDFRT:N0000007630

Boric Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Boron Compounds
PMOID: PMO:00015145
Subclass_of: Acids, Noncarboxylic
Subclass_of: Boron Compounds
Synonym: Acids, Boric
Synonym: Boric Acids [Chemical/Ingredient]
Tree Number: T6.1.1.1.1
Tree Number: T6.1.4.2
Tree Number: T6.2.11.2
database_cross_reference: MSH:D001888
database_cross_reference: NDFRT:N0000008066

Borinic Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Boron Compounds
PMOID: PMO:00015146
Subclass_of: Acids, Noncarboxylic
Subclass_of: Boron Compounds
Synonym: Acids, Borinic
Synonym: Borinic Acids [Chemical/Ingredient]
Tree Number: T6.1.1.1.2
Tree Number: T6.1.4.3
Tree Number: T6.2.11.3
database_cross_reference: MSH:D001889
database_cross_reference: NDFRT:N0000166857

Boronic Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Boron Compounds
PMOID: PMO:00015147
Subclass_of: Acids, Noncarboxylic
Subclass_of: Boron Compounds
Synonym: Acids, Boronic
Synonym: Boronic Acids [Chemical/Ingredient]
Tree Number: T6.1.1.1.3
Tree Number: T6.1.4.4
Tree Number: T6.2.11.4
database_cross_reference: MSH:D001897
database_cross_reference: NDFRT:N0000011463

Bortezomib
type: Class
subclass of: Boronic Acids
subclass of: PMO:00018308
PMOID: PMO:00015148
Subclass_of: Boronic Acids
Subclass_of: Pyrazines
Synonym: Act Bortezomib
Synonym: BORTEZOMIB
Synonym: Bortezomib (product)
Synonym: Bortezomib (substance)
Synonym: Bortezomib [Chemical/Ingredient]
Synonym: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
Synonym: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
Synonym: PMS-bortezomib
Synonym: [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid
Synonym: [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
Tree Number: T6.1.4.4.1
Tree Number: T6.2.11.4.1
Tree Number: T6.3.5.18.2
database_cross_reference: ATC:L01XX32
database_cross_reference: CHV:0000055829
database_cross_reference: DRUGBANK:DB00188
database_cross_reference: MEDCIN:258083
database_cross_reference: MMSL:17263
database_cross_reference: MMSL:d04871
database_cross_reference: MSH:D000069286
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:69G8BD63PP
database_cross_reference: NCI:C1851
database_cross_reference: NCI_DCP:31947
database_cross_reference: NCI_FDA:69G8BD63PP
database_cross_reference: NCI_NCI-GLOSS:CDR0000269133
database_cross_reference: NDDF:009985
database_cross_reference: NDFRT:N0000010079
database_cross_reference: NDFRT:N0000148811
database_cross_reference: PDQ:CDR0000043560
database_cross_reference: RXNORM:358258
database_cross_reference: SNOMEDCT_US:398907002
database_cross_reference: SNOMEDCT_US:407097007
database_cross_reference: VANDF:4021393

Carbonic Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Carbon Compounds, Inorganic
PMOID: PMO:00015149
Subclass_of: Acids, Noncarboxylic
Subclass_of: Carbon Compounds, Inorganic
Synonym: Acid, Carbonic
Synonym: Carbonic Acid [Chemical/Ingredient]
Synonym: Carbonic acid
Synonym: Carbonic acid (substance)
Synonym: carbonic acid
Tree Number: T6.1.1.1.4
Tree Number: T6.1.16.4
database_cross_reference: CHV:0000002400
database_cross_reference: LCH_NW:sh89006832
database_cross_reference: MSH:D002255
database_cross_reference: NDFRT:N0000008133
database_cross_reference: SNM:F-10190
database_cross_reference: SNMI:C-10523
database_cross_reference: SNOMEDCT_US:37938000

Hydrochloric Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Chlorine Compounds
PMOID: PMO:00015150
Subclass_of: Acids, Noncarboxylic
Subclass_of: Chlorine Compounds
Synonym: Acid, Hydrochloric
Synonym: Acid, Muriatic
Synonym: Chloride, Hydrogen
Synonym: HCL
Synonym: HCl
Synonym: HYDROCHLORIC ACID
Synonym: Hydrochloric Acid (HCL)
Synonym: Hydrochloric Acid [Chemical/Ingredient]
Synonym: Hydrochloric acid
Synonym: Hydrochloric acid (product)
Tree Number: T6.1.1.1.5
Tree Number: T6.1.20.4
database_cross_reference: ALT:HAMCP
database_cross_reference: AOD:0000019572
database_cross_reference: ATC:A09AB03
database_cross_reference: ATC:B05XA13
database_cross_reference: CHV:0000006346
database_cross_reference: CSP:1371-6102
database_cross_reference: LCH:U002273
database_cross_reference: LCH_NW:sh85063381
database_cross_reference: MEDCIN:41265
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D006851
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: MTHSPL:QTT17582CB
database_cross_reference: NCI:C76716
database_cross_reference: NCI_FDA:QTT17582CB
database_cross_reference: NDDF:001112
database_cross_reference: NDFRT:N0000006448
database_cross_reference: NDFRT:N0000146547
database_cross_reference: RCD:X90Ed
database_cross_reference: RXNORM:5486
database_cross_reference: SNM:E-5022
database_cross_reference: SNMI:C-10220
database_cross_reference: SNOMEDCT_US:27763000
database_cross_reference: SNOMEDCT_US:420502008
database_cross_reference: VANDF:4018214

Hydrogen Cyanide
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Nitrogen Compounds
PMOID: PMO:00015151
Subclass_of: Acids, Noncarboxylic
Subclass_of: Nitrogen Compounds
Synonym: Acid, Hydrocyanic
Synonym: Cyanhydric acid
Synonym: Cyanide, Hydrogen
Synonym: HYDROGEN CYANIDE
Synonym: Hydrocyanic Acid
Synonym: Hydrocyanic acid
Synonym: Hydrocyanic acid (substance)
Synonym: Hydrogen Cyanide [Chemical/Ingredient]
Synonym: Hydrogen cyanide
Synonym: Prussic acid
Tree Number: T6.1.1.1.6
Tree Number: T6.1.33.5
database_cross_reference: CHV:0000006352
database_cross_reference: LCH:U002275
database_cross_reference: LCH_NW:sh85063385
database_cross_reference: MSH:D006856
database_cross_reference: MTH:U001989
database_cross_reference: MTHSPL:2WTB3V159F
database_cross_reference: NCI:C77470
database_cross_reference: NCI_FDA:2WTB3V159F
database_cross_reference: NDFRT:N0000008281
database_cross_reference: RCD:XaD1S
database_cross_reference: RXNORM:1367183
database_cross_reference: SNM:E-5054
database_cross_reference: SNMI:C-10540
database_cross_reference: SNOMEDCT_US:54841005

Hydrofluoric Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Fluorine Compounds
PMOID: PMO:00015152
Subclass_of: Acids, Noncarboxylic
Subclass_of: Fluorine Compounds
Synonym: Acid, Fluohydric
Synonym: Acid, Fluorhydric
Synonym: Acid, Hydrofluoric
Synonym: Alpha-Pro
Synonym: Denti-Care Topical Fluoride Foam Bubble Gum
Synonym: Denti-Care Topical Fluoride Foam Grape
Synonym: Denti-Care Topical Fluoride Foam Orange
Synonym: Denti-Care Topical Fluoride Foam Raspberry
Synonym: Denti-Care Topical Sodium Fluoride Strawberry
Synonym: Fluohydric Acid
Tree Number: T6.1.1.1.7
Tree Number: T6.1.25.1
database_cross_reference: CHV:0000006353
database_cross_reference: CSP:0030-0942
database_cross_reference: DRUGBANK:DB11072
database_cross_reference: LCH:U002276
database_cross_reference: LCH_NW:sh85063411
database_cross_reference: LNC:LP34850-5
database_cross_reference: LNC:MTHU017657
database_cross_reference: MMSL:4846
database_cross_reference: MSH:D006858
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:RGL5YE86CZ
database_cross_reference: NCI:C82286
database_cross_reference: NCI_FDA:RGL5YE86CZ
database_cross_reference: NDDF:003889
database_cross_reference: NDFRT:N0000006470
database_cross_reference: NDFRT:N0000146794
database_cross_reference: RCD:XaD6A
database_cross_reference: RCD:XaD6B
database_cross_reference: RXNORM:5496
database_cross_reference: SNM:E-5023
database_cross_reference: SNMI:C-10230
database_cross_reference: SNOMEDCT_US:311993005
database_cross_reference: SNOMEDCT_US:42757007
database_cross_reference: VANDF:4018471

Hydrogen Sulfide
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Gases
subclass of: Sulfur Compounds
PMOID: PMO:00015153
Subclass_of: Acids, Noncarboxylic
Subclass_of: Gases
Subclass_of: Sulfur Compounds
Synonym: Hydrogen Sulfide [Chemical/Ingredient]
Synonym: Hydrogen sulfide
Synonym: Hydrogen sulfide (H2S)
Synonym: Hydrogen sulfide (substance)
Synonym: Hydrogen sulphide
Synonym: Sulfide, Hydrogen
Synonym: Sulfur hydride
Synonym: Sulphur hydride
Synonym: hydrogen sulfide
Synonym: hydrogen sulphide
Tree Number: T6.1.1.1.8
Tree Number: T6.1.13.1
Tree Number: T6.1.8.8
database_cross_reference: CHV:0000006357
database_cross_reference: CSP:2837-1786
database_cross_reference: LCH_NW:sh85063433
database_cross_reference: LNC:LP15644-5
database_cross_reference: LNC:MTHU011758
database_cross_reference: MSH:D006862
database_cross_reference: MTH:U001990
database_cross_reference: NDFRT:N0000008233
database_cross_reference: RCD:XaD1V
database_cross_reference: RCDAE:XaD1V
database_cross_reference: SNM:E-5082
database_cross_reference: SNMI:C-10812
database_cross_reference: SNOMEDCT_US:27390006

Hypochlorous Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Oxides
subclass of: Reactive Oxygen Species
subclass of: Chlorine Compounds
PMOID: PMO:00015154
Subclass_of: Acids, Noncarboxylic
Subclass_of: Chlorine Compounds
Subclass_of: Oxides
Subclass_of: Reactive Oxygen Species
Synonym: HYPOCHLOROUS ACID
Synonym: Hypochlorous Acid [Chemical/Ingredient]
Synonym: Hypochlorous acid
Synonym: Hypochlorous acid (substance)
Synonym: hypochlorous acid
Tree Number: T6.1.1.1.9
Tree Number: T6.1.18.1.4
Tree Number: T6.1.20.5
Tree Number: T6.1.7.2.1
database_cross_reference: CHV:0000006469
database_cross_reference: MSH:D006997
database_cross_reference: MTHSPL:712K4CDC10
database_cross_reference: NDDF:013504
database_cross_reference: NDFRT:N0000007498
database_cross_reference: NDFRT:N0000188990
database_cross_reference: RXNORM:1483316
database_cross_reference: SNMI:C-10410
database_cross_reference: SNOMEDCT_US:35690007
database_cross_reference: VANDF:4032746

Nitrous Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Nitrogen Compounds
PMOID: PMO:00015155
Subclass_of: Acids, Noncarboxylic
Subclass_of: Nitrogen Compounds
Synonym: Acid, Nitrous
Synonym: Nitrous Acid [Chemical/Ingredient]
Synonym: Nitrous acid
Synonym: Nitrous acid (substance)
Synonym: nitrous acid
Tree Number: T6.1.1.1.10
Tree Number: T6.1.33.7
database_cross_reference: AOD:0000019600
database_cross_reference: CSP:2083-3379
database_cross_reference: LCH:U003252
database_cross_reference: LCH_NW:sh85092096
database_cross_reference: MSH:D009608
database_cross_reference: NDFRT:N0000008205
database_cross_reference: SNM:E-5079
database_cross_reference: SNMI:C-10730
database_cross_reference: SNOMEDCT_US:30749004

Perchlorates
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Chlorine Compounds
PMOID: PMO:00015156
Subclass_of: Acids, Noncarboxylic
Subclass_of: Chlorine Compounds
Synonym: Perchlorates [Chemical/Ingredient]
Tree Number: T6.1.1.1.11
Tree Number: T6.1.20.6
database_cross_reference: MSH:D010472
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000189416

Periodic Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Iodine Compounds
PMOID: PMO:00015157
Subclass_of: Acids, Noncarboxylic
Subclass_of: Iodine Compounds
Synonym: Acid, Paraperiodic
Synonym: Acid, Periodic
Synonym: Paraperiodic Acid
Synonym: Periodic Acid [Chemical/Ingredient]
Synonym: Periodic acid
Synonym: Periodic acid (H5IO6)
Synonym: paraperiodic acid
Synonym: periodic acid
Tree Number: T6.1.1.1.12
Tree Number: T6.1.27.4
database_cross_reference: AOD:0000019596
database_cross_reference: CHV:0000009500
database_cross_reference: CSP:0030-0942
database_cross_reference: LCH_NW:sh89006199
database_cross_reference: MSH:D010504
database_cross_reference: NDFRT:N0000166200

Silicic Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Silicon Dioxide
PMOID: PMO:00015158
Subclass_of: Acids, Noncarboxylic
Subclass_of: Silicon Dioxide
Synonym: Gel, Hydrated Silica
Synonym: HYDRATED SILICA
Synonym: Hydrate, Silica
Synonym: Hydrate, Silicate
Synonym: Hydrated Silica
Synonym: Hydrated Silica Gel
Synonym: Hydrated silica
Synonym: Silica Gel, Hydrated
Synonym: Silica Hydrate
Synonym: Silicate Hydrate
Tree Number: T6.1.1.1.13
Tree Number: T6.1.29.2.3
database_cross_reference: LCH:U004314
database_cross_reference: LCH_NW:sh85122508
database_cross_reference: MSH:D012824
database_cross_reference: MTHSPL:Y6O7T4G8P9
database_cross_reference: NDDF:007387
database_cross_reference: NDDF:010496
database_cross_reference: NDFRT:N0000007598
database_cross_reference: RXNORM:1311243

Sulfur Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Sulfur Compounds
PMOID: PMO:00015159
Subclass_of: Acids, Noncarboxylic
Subclass_of: Sulfur Compounds
Synonym: Acids, Sulfur
Synonym: Sulfur Acids [Chemical/Ingredient]
Synonym: Sulfur acids
Synonym: acid sulfur
Synonym: sulfur acid
Synonym: sulfur acids
Tree Number: T6.1.1.1.14
Tree Number: T6.1.13.3
Tree Number: T6.2.32.11
database_cross_reference: CHV:0000011875
database_cross_reference: LCH_NW:sh2007003784
database_cross_reference: MSH:D013456
database_cross_reference: NDFRT:N0000008248

Sulfinic Acids
type: Class
subclass of: Sulfur Acids
PMOID: PMO:00015160
Subclass_of: Sulfur Acids
Synonym: Acids, Sulfinic
Synonym: Sulfinic Acids [Chemical/Ingredient]
Tree Number: T6.1.13.3.1
Tree Number: T6.2.32.11.2
database_cross_reference: MSH:D013441
database_cross_reference: NDFRT:N0000166476

Sulfonic Acids
type: Class
subclass of: Sulfur Acids
PMOID: PMO:00015161
Subclass_of: Sulfur Acids
Synonym: Acids, Sulfonic
Synonym: Sulfonic Acids [Chemical/Ingredient]
Synonym: acid sulfonic
Synonym: sulfonic acid
Tree Number: T6.1.13.3.2
Tree Number: T6.2.32.11.3
database_cross_reference: AOD:0000019953
database_cross_reference: CHV:0000011870
database_cross_reference: MSH:D013451
database_cross_reference: NDDF:007190
database_cross_reference: NDFRT:N0000008245

Sulfuric Acids
type: Class
subclass of: Sulfur Acids
PMOID: PMO:00015163
Subclass_of: Sulfur Acids
Synonym: Acids, Sulfuric
Synonym: Sulfuric Acids [Chemical/Ingredient]
Synonym: Sulfuric acid
Tree Number: T6.1.13.3.3
Tree Number: T6.2.32.11.4
database_cross_reference: LCH_NW:sh85130391
database_cross_reference: MSH:D013464
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008059

Nitric Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Nitrogen Compounds
PMOID: PMO:00015165
Subclass_of: Acids, Noncarboxylic
Subclass_of: Nitrogen Compounds
Synonym: Acid, Nitric
Synonym: Aqua fortis / nitric acid
Synonym: Hydrogen Nitrate
Synonym: NITRIC ACID
Synonym: Nitric Acid [Chemical/Ingredient]
Synonym: Nitric acid
Synonym: Nitric acid (substance)
Synonym: acid nitric
Synonym: aqua fortis/nitric acid
Synonym: nitric acid
Tree Number: T6.1.1.1.15
Tree Number: T6.1.33.9
database_cross_reference: ALT:HAAEZ
database_cross_reference: CHV:0000014505
database_cross_reference: LCH:U005843
database_cross_reference: LCH_NW:sh85092048
database_cross_reference: MSH:D017942
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:411VRN1TV4
database_cross_reference: NCI:C28202
database_cross_reference: NCI_FDA:411VRN1TV4
database_cross_reference: NCI_NCI-GLOSS:CDR0000044136
database_cross_reference: NDDF:005607
database_cross_reference: NDFRT:N0000008166
database_cross_reference: RCD:X90Ej
database_cross_reference: RXNORM:1311391
database_cross_reference: SNM:E-5024
database_cross_reference: SNMI:C-10240
database_cross_reference: SNOMEDCT_US:59442008

Phosphorus Acids
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Phosphorus Compounds
PMOID: PMO:00015166
Subclass_of: Acids, Noncarboxylic
Subclass_of: Phosphorus Compounds
Synonym: Acids, Phosphorus
Synonym: Phosphorus Acids [Chemical/Ingredient]
Synonym: phosphorus acid
Tree Number: T6.1.1.1.16
Tree Number: T6.1.15.4
database_cross_reference: CSP:0030-0942
database_cross_reference: MSH:D017976
database_cross_reference: NDFRT:N0000007696

Phosphinic Acids
type: Class
subclass of: Phosphorus Acids
subclass of: PMO:00017291
PMOID: PMO:00015167
Subclass_of: Organophosphorus Compounds
Subclass_of: Phosphorus Acids
Synonym: Acids, Hypophosphorous
Synonym: Acids, Phosphinic
Synonym: Hypophosphorous Acids
Synonym: Phosphinic Acids [Chemical/Ingredient]
Synonym: Phosphinic acid
Tree Number: T6.1.15.4.1
Tree Number: T6.2.29.3
database_cross_reference: LCH_NW:sh2005008190
database_cross_reference: MSH:D010721
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166429

Phosphoric Acids
type: Class
subclass of: Phosphorus Acids
PMOID: PMO:00015168
Subclass_of: Phosphorus Acids
Synonym: Acids, Phosphoric
Synonym: Phosphoric Acids [Chemical/Ingredient]
Synonym: acid phosphoric
Synonym: phosphoric acid
Tree Number: T6.1.15.4.2
database_cross_reference: AOD:0000019623
database_cross_reference: CHV:0000009675
database_cross_reference: MSH:D010756
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000006915

Struvite
type: Class
subclass of: Magnesium Compounds
PMOID: PMO:00015170
Subclass_of: Magnesium Compounds
Synonym: Struvate
Synonym: Struvate (substance)
Synonym: Struvite (substance)
Synonym: Struvite [Chemical/Ingredient]
Synonym: struvite
Tree Number: T6.1.28.1
database_cross_reference: CHV:0000014871
database_cross_reference: MSH:D000069877
database_cross_reference: NDFRT:N0000192949
database_cross_reference: RCD:XC0ux
database_cross_reference: SNOMEDCT_US:264928008

Acidulated Phosphate Fluoride
type: Class
subclass of: Sodium Fluoride
subclass of: PMO:00024406
PMOID: PMO:00015171
Subclass_of: Cariostatic Agents
Subclass_of: Sodium Fluoride
Synonym: ACIDULATED PHOSPHATE FLUORIDE
Synonym: Acid Phosphate Fluoride
Synonym: Acidulated Phosphate Fluoride [Chemical/Ingredient]
Synonym: Acidulated phosphate fluoride
Synonym: Acidulated phosphate fluoride (substance)
Synonym: Fluoride, Acid Phosphate
Synonym: Fluoride, Acidulated Phosphate
Synonym: Phosphate Fluoride, Acidulated
Synonym: Phosphoric acid, mixt. with sodium fluoride (NaF)
Synonym: acidulated fluoride phosphate
Tree Number: T6.1.31.3.1
Tree Number: T6.14.4.1
database_cross_reference: MEDCIN:250631
database_cross_reference: MMSL:10398
database_cross_reference: MSH:D000149
database_cross_reference: NDFRT:N0000006411
database_cross_reference: NDFRT:N0000148064
database_cross_reference: RXNORM:236
database_cross_reference: SNMI:C-B70C2
database_cross_reference: SNOMEDCT_US:55495002
database_cross_reference: VANDF:4019988

Calcium Phosphates
type: Class
subclass of: Calcium Compounds
PMOID: PMO:00015172
Subclass_of: Calcium Compounds
Synonym: Calcium Phosphates [Chemical/Ingredient]
Synonym: Calcium phosphates
Synonym: Calcium/Phosphate
Synonym: Phosphates, Calcium
Synonym: calcium phosphates
Synonym: phosphates calcium
Tree Number: T6.1.24.5
database_cross_reference: CHV:0000002306
database_cross_reference: DRUGBANK:DB11348
database_cross_reference: LNC:LP28906-3
database_cross_reference: LNC:MTHU006836
database_cross_reference: MSH:D002130
database_cross_reference: NDFRT:N0000007989

Apatites
type: Class
subclass of: Calcium Phosphates
subclass of: Minerals
PMOID: PMO:00015173
Subclass_of: Calcium Phosphates
Subclass_of: Minerals
Synonym: Apatite
Synonym: Apatites [Chemical/Ingredient]
Synonym: apatite
Tree Number: T6.1.11.1
Tree Number: T6.1.24.5.1
database_cross_reference: CHV:0000001365
database_cross_reference: CSP:0532-2130
database_cross_reference: DRUGBANK:DB09484
database_cross_reference: LCH:U000323
database_cross_reference: LCH_NW:sh85005932
database_cross_reference: MSH:D001031
database_cross_reference: NDFRT:N0000166283
database_cross_reference: RCD:X80N1
database_cross_reference: SNOMEDCT_US:259546007

Hydroxyapatites
type: Class
subclass of: Apatites
PMOID: PMO:00015174
Subclass_of: Apatites
Synonym: Derivatives, Hydroxyapatite
Synonym: Hydroxyapatite Derivatives
Synonym: Hydroxyapatites [Chemical/Ingredient]
Tree Number: T6.1.11.1.1
database_cross_reference: MSH:D006882
database_cross_reference: NDFRT:N0000166284

Calcium Pyrophosphate
type: Class
subclass of: Calcium Phosphates
PMOID: PMO:00015176
Subclass_of: Calcium Phosphates
Synonym: CALCIUM PYROPHOSPHATE
Synonym: Calcium Diphosphate
Synonym: Calcium Pyrophosphate [Chemical/Ingredient]
Synonym: Calcium pyrophosphate
Synonym: Calcium pyrophosphate (substance)
Synonym: Diphosphate, Calcium
Synonym: Diphosphoric acid, calcium salt
Synonym: Pyrophosphate, Calcium
Synonym: calcium diphosphate
Synonym: calcium pyrophosphate
Tree Number: T6.1.24.5.2
database_cross_reference: CHV:0000002307
database_cross_reference: MSH:D002131
database_cross_reference: MTHSPL:X69NU20D19
database_cross_reference: NCI:C75639
database_cross_reference: NCI_FDA:X69NU20D19
database_cross_reference: NDDF:010438
database_cross_reference: NDFRT:N0000166212
database_cross_reference: RCD:XaDpH
database_cross_reference: RXNORM:1362901
database_cross_reference: SNOMEDCT_US:312258005

Technetium Tc 99m Pyrophosphate
type: Class
subclass of: Technetium Compounds
PMOID: PMO:00015179
Subclass_of: Technetium Compounds
Synonym: 99mTc Pyrophosphate
Synonym: 99mTc-Pyrophosphate
Synonym: Diphosphoric Acid, Technetium Salt
Synonym: Kit for the Preparation of Technetium Tc99m Pyrophosphate
Synonym: TC PYRO
Synonym: TC PYROPHOSPHATE 099M
Synonym: TECHNETIUM TC PYROPHOSPHATE 099M
Synonym: TECHNETIUM TC-99M PYROPHOSPHATE
Synonym: Tc 99m Pyrophosphate
Synonym: Tc 99m-Pyrophosphate
Tree Number: T6.1.17.3
database_cross_reference: DRUGBANK:DB09165
database_cross_reference: MSH:D016698
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5L76I61H2B
database_cross_reference: NCI:C90869
database_cross_reference: NCI_FDA:5L76I61H2B
database_cross_reference: NDFRT:N0000166195
database_cross_reference: RXNORM:1488368
database_cross_reference: SNM:E-5278

Tin Polyphosphates
type: Class
subclass of: Tin Compounds
PMOID: PMO:00015180
Subclass_of: Tin Compounds
Synonym: Polyphosphates, Tin
Synonym: Tin Polyphosphates [Chemical/Ingredient]
Tree Number: T6.1.40.2
database_cross_reference: MSH:D014003
database_cross_reference: NDFRT:N0000166217

Phosphoramides
type: Class
subclass of: PMO:00017291
PMOID: PMO:00015181
Subclass_of: Organophosphorus Compounds
Synonym: Phosphoramides [Chemical/Ingredient]
Tree Number: T6.2.29.7
database_cross_reference: MSH:D063088
database_cross_reference: NDFRT:N0000185716

Phosphotungstic Acid
type: Class
subclass of: Tungsten Compounds
PMOID: PMO:00015182
Subclass_of: Tungsten Compounds
Synonym: Acid, Phosphotungstic
Synonym: Phosphotungstic Acid [Chemical/Ingredient]
Synonym: Tungsten hydroxide oxide phosphate
Tree Number: T6.1.41.1
database_cross_reference: MSH:D010772
database_cross_reference: NDFRT:N0000166201

Phosphorous Acids
type: Class
subclass of: Phosphorus Acids
PMOID: PMO:00015183
Subclass_of: Phosphorus Acids
Synonym: Acids, Phosphorous
Synonym: Phosphorous Acids [Chemical/Ingredient]
Tree Number: T6.1.15.4.3
database_cross_reference: MSH:D010757
database_cross_reference: NDFRT:N0000166426

Hydrobromic Acid
type: Class
subclass of: Acids, Noncarboxylic
subclass of: Bromine Compounds
PMOID: PMO:00015184
Subclass_of: Acids, Noncarboxylic
Subclass_of: Bromine Compounds
Synonym: Acid, Hydrobromic
Synonym: Bromide, Hydrogen
Synonym: HYDROBROMIC ACID
Synonym: Hydrobromic Acid [Chemical/Ingredient]
Synonym: Hydrobromic acid
Synonym: Hydrobromic acid (substance)
Synonym: Hydrogen Bromide
Synonym: Hydrogen bromide
Synonym: hydrobromic acid
Tree Number: T6.1.1.1.17
Tree Number: T6.1.19.2
database_cross_reference: LCH:U005118
database_cross_reference: LCH_NW:sh85063370
database_cross_reference: MSH:D018054
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:3IY7CNP8XJ
database_cross_reference: NDDF:010263
database_cross_reference: NDFRT:N0000166202
database_cross_reference: RXNORM:1426869
database_cross_reference: SNM:E-5021
database_cross_reference: SNMI:C-10210
database_cross_reference: SNOMEDCT_US:84274008

Lewis Acids
type: Class
subclass of: Acids
subclass of: Organic Chemicals
PMOID: PMO:00015185
Subclass_of: Acids
Subclass_of: Organic Chemicals
Synonym: Acids, Lewis
Synonym: Lewis Acids [Chemical/Ingredient]
Synonym: Lewis acid
Synonym: Lewis acid (substance)
Synonym: Lewis acids
Tree Number: T6.1.1.2
Tree Number: T6.2.42
database_cross_reference: LCH_NW:sh89004433
database_cross_reference: MSH:D058116
database_cross_reference: NDFRT:N0000182057
database_cross_reference: SNMI:C-10043
database_cross_reference: SNOMEDCT_US:49426007

Alkalies
type: Class
subclass of: Inorganic Chemicals
PMOID: PMO:00015186
Subclass_of: Inorganic Chemicals
Synonym: Alkali
Synonym: Alkali (substance)
Synonym: Alkali, NOS
Synonym: Alkalies [Chemical/Ingredient]
Synonym: Alkalis
Synonym: alkali
Synonym: alkalies
Synonym: alkalis
Synonym: alkalising
Synonym: base
Tree Number: T6.1.2
database_cross_reference: AOD:0000028722
database_cross_reference: CHV:0000000897
database_cross_reference: LCH:U000144
database_cross_reference: LCH_NW:sh85003591
database_cross_reference: MSH:D000468
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI_NCI-GLOSS:CDR0000643003
database_cross_reference: NCI_NCI-GLOSS:CDR0000689975
database_cross_reference: NDFRT:N0000008132
database_cross_reference: RCD:X794B
database_cross_reference: SNM:E-5003
database_cross_reference: SNMI:C-10055
database_cross_reference: SNOMEDCT_US:63813000

Carbonates
type: Class
subclass of: Carbonic Acid
subclass of: Alkalies
PMOID: PMO:00015187
Subclass_of: Alkalies
Subclass_of: Carbonic Acid
Synonym: Carbonate
Synonym: Carbonate (substance)
Synonym: Carbonates [Chemical/Ingredient]
Synonym: carbonate
Synonym: carbonated
Synonym: carbonates
Tree Number: T6.1.16.4.1
Tree Number: T6.1.2.1
database_cross_reference: CHV:0000002399
database_cross_reference: CSP:0558-7159
database_cross_reference: LCH:U000789
database_cross_reference: LCH_NW:sh85020136
database_cross_reference: LNC:LP15472-1
database_cross_reference: LNC:MTHU004921
database_cross_reference: MSH:D002254
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007504
database_cross_reference: RCD:X8071
database_cross_reference: SNOMEDCT_US:259094000

Lithium Carbonate
type: Class
subclass of: Carbonates
subclass of: Lithium Compounds
PMOID: PMO:00015188
Subclass_of: Carbonates
Subclass_of: Lithium Compounds
Synonym: Carbonate, Dilithium
Synonym: Carbonate, Lithium
Synonym: Carbonic acid, dilithium salt
Synonym: Dilithium Carbonate
Synonym: LITHIUM CARBONATE
Synonym: Lithium Carbonate [Chemical/Ingredient]
Synonym: Lithium carbonate
Synonym: Lithium carbonate (product)
Synonym: Lithium carbonate (substance)
Synonym: Lithium carbonate preparation
Tree Number: T6.1.2.1.1
Tree Number: T6.1.44.1
database_cross_reference: CHV:0000015502
database_cross_reference: DRUGBANK:DB01356
database_cross_reference: MEDCIN:41360
database_cross_reference: MMSL:1990
database_cross_reference: MMSL:4986
database_cross_reference: MSH:D016651
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2BMD2GNA4V
database_cross_reference: NCI:C1318
database_cross_reference: NCI_DTP:NSC0016895
database_cross_reference: NCI_FDA:2BMD2GNA4V
database_cross_reference: NDDF:001533
database_cross_reference: NDFRT:N0000006445
database_cross_reference: NDFRT:N0000146351
database_cross_reference: PDQ:CDR0000039491
database_cross_reference: PSY:28610
database_cross_reference: RCD:d61..
database_cross_reference: RXNORM:42351
database_cross_reference: SNM:E-7960
database_cross_reference: SNMI:C-63C11
database_cross_reference: SNOMEDCT_US:16977003
database_cross_reference: SNOMEDCT_US:387095003
database_cross_reference: USPMG:MTHU000812
database_cross_reference: VANDF:4018007

Hydroxides
type: Class
subclass of: Alkalies
PMOID: PMO:00015189
Subclass_of: Alkalies
Synonym: Hydroxides [Chemical/Ingredient]
Synonym: hydroxides
Tree Number: T6.1.2.2
database_cross_reference: AOD:0000019573
database_cross_reference: CHV:0000006371
database_cross_reference: LCH:U002290
database_cross_reference: LCH_NW:sh85063504
database_cross_reference: MSH:D006878
database_cross_reference: MTH:U001992
database_cross_reference: NDFRT:N0000007982

Aluminum Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Aluminum Compounds
PMOID: PMO:00015190
Subclass_of: Aluminum Compounds
Subclass_of: Hydroxides
Synonym: ALUMINUM (AS HYDROXIDE)
Synonym: ALUMINUM HYDROXIDE
Synonym: Al(OH)3
Synonym: Alum Adjuvant
Synonym: Alumina, Hydrated
Synonym: Aluminium hydroxide
Synonym: Aluminium hydroxide (in vac)
Synonym: Aluminium hydroxide (in vaccine)
Synonym: Aluminium hydroxide - chemical
Synonym: Aluminium hydroxide [antacid]
Tree Number: T6.1.2.2.1
Tree Number: T6.1.21.2
database_cross_reference: ATC:A02AB01
database_cross_reference: CHV:0000000957
database_cross_reference: DRUGBANK:DB06723
database_cross_reference: LCH:U000170
database_cross_reference: LCH_NW:sh85004013
database_cross_reference: MEDCIN:40852
database_cross_reference: MMSL:4159
database_cross_reference: MMSL:7537
database_cross_reference: MMSL:d00978
database_cross_reference: MSH:D000536
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5QB0T2IUN0
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C39707
database_cross_reference: NCI_DTP:NSC0664400
database_cross_reference: NCI_FDA:5QB0T2IUN0
database_cross_reference: NDDF:001123
database_cross_reference: NDFRT:N0000006641
database_cross_reference: NDFRT:N0000146330
database_cross_reference: NDFRT:N0000146920
database_cross_reference: PDQ:CDR0000042000
database_cross_reference: RCD:X794W
database_cross_reference: RCD:XM0l1
database_cross_reference: RCD:a11..
database_cross_reference: RCD:ij1..
database_cross_reference: RCD:x02L7
database_cross_reference: RCDAE:X794W
database_cross_reference: RCDAE:XM0l1
database_cross_reference: RCDAE:a11..
database_cross_reference: RCDAE:ij1..
database_cross_reference: RCDAE:x02L7
database_cross_reference: RXNORM:612
database_cross_reference: SNM:E-8213
database_cross_reference: SNMI:C-84212
database_cross_reference: SNOMEDCT_US:255628000
database_cross_reference: SNOMEDCT_US:273944007
database_cross_reference: SNOMEDCT_US:316932002
database_cross_reference: SNOMEDCT_US:329185005
database_cross_reference: SNOMEDCT_US:80399002
database_cross_reference: VANDF:4017984
database_cross_reference: VANDF:4018607

Calcium Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Calcium Compounds
PMOID: PMO:00015191
Subclass_of: Calcium Compounds
Subclass_of: Hydroxides
Synonym: CALCIUM HYDROXIDE
Synonym: Ca(OH) - Calcium hydroxide
Synonym: Ca(OH) - calcium hydroxide
Synonym: Calcium Hydroxide [Chemical/Ingredient]
Synonym: Calcium hydroxide
Synonym: Calcium hydroxide (Ca(OH)2)
Synonym: Calcium hydroxide (substance)
Synonym: Hydroxide, Calcium
Synonym: LIME WATER
Synonym: Lime water
Tree Number: T6.1.2.2.2
Tree Number: T6.1.24.4
database_cross_reference: CHV:0000002301
database_cross_reference: LCH_NW:sh90004203
database_cross_reference: MEDCIN:199190
database_cross_reference: MMSL:72391
database_cross_reference: MMSL:7477
database_cross_reference: MSH:D002126
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:PF5DZW74VN
database_cross_reference: NCI:C77032
database_cross_reference: NCI_FDA:PF5DZW74VN
database_cross_reference: NDDF:001118
database_cross_reference: NDFRT:N0000006550
database_cross_reference: NDFRT:N0000147560
database_cross_reference: NDFRT:N0000147684
database_cross_reference: RCD:Xa6Yw
database_cross_reference: RXNORM:1910
database_cross_reference: SNM:E-8012
database_cross_reference: SNM:E-8052
database_cross_reference: SNMI:C-A7060
database_cross_reference: SNOMEDCT_US:7325009
database_cross_reference: VANDF:4019429
database_cross_reference: VANDF:4019587

Lye
type: Class
subclass of: Hydroxides
PMOID: PMO:00015192
Subclass_of: Hydroxides
Synonym: Lixivium
Synonym: Lye (substance)
Synonym: Lye [Chemical/Ingredient]
Synonym: lye
Synonym: lyes
Tree Number: T6.1.2.2.3
database_cross_reference: CHV:0000007587
database_cross_reference: LCH:U002753
database_cross_reference: LCH_NW:sh85079104
database_cross_reference: MSH:D008191
database_cross_reference: NDFRT:N0000166220
database_cross_reference: RCD:XaD1C
database_cross_reference: SNM:E-5030
database_cross_reference: SNMI:C-10300
database_cross_reference: SNOMEDCT_US:311721007
database_cross_reference: SNOMEDCT_US:61504000

Magnesium Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Magnesium Compounds
PMOID: PMO:00015193
Subclass_of: Hydroxides
Subclass_of: Magnesium Compounds
Synonym: Hydrate, Magnesium
Synonym: Hydroxide, Magnesium
Synonym: MAGNESIUM HYDROXIDE
Synonym: Magnesium Hydrate
Synonym: Magnesium Hydroxide [Chemical/Ingredient]
Synonym: Magnesium dihydroxide
Synonym: Magnesium hydrate
Synonym: Magnesium hydrate (substance)
Synonym: Magnesium hydroxide
Synonym: Magnesium hydroxide (Mg(OH)2)
Tree Number: T6.1.2.2.4
Tree Number: T6.1.28.2
database_cross_reference: ATC:A02AA04
database_cross_reference: ATC:G04BX01
database_cross_reference: CHV:0000007663
database_cross_reference: DRUGBANK:DB09104
database_cross_reference: MEDCIN:40864
database_cross_reference: MMSL:5013
database_cross_reference: MMSL:5579
database_cross_reference: MMSL:d00982
database_cross_reference: MSH:D008276
database_cross_reference: MTHSPL:NBZ3QY004S
database_cross_reference: NCI:C29262
database_cross_reference: NCI_DCP:1278
database_cross_reference: NCI_FDA:NBZ3QY004S
database_cross_reference: NDDF:001119
database_cross_reference: NDDF:001186
database_cross_reference: NDFRT:N0000006344
database_cross_reference: NDFRT:N0000146067
database_cross_reference: RCD:ae2..
database_cross_reference: RCD:x007O
database_cross_reference: RXNORM:6581
database_cross_reference: SNM:E-8215
database_cross_reference: SNM:E-8222
database_cross_reference: SNMI:C-84232
database_cross_reference: SNMI:C-84270
database_cross_reference: SNOMEDCT_US:25550008
database_cross_reference: SNOMEDCT_US:317584009
database_cross_reference: SNOMEDCT_US:387337001
database_cross_reference: SNOMEDCT_US:60468008
database_cross_reference: VANDF:4017693

Sodium Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Sodium Compounds
PMOID: PMO:00015194
Subclass_of: Hydroxides
Subclass_of: Sodium Compounds
Synonym: Caustic Soda
Synonym: Caustic alkali of sodium
Synonym: Hydroxide, Sodium
Synonym: SODIUM HYDROXIDE
Synonym: SOdium Hydroxide
Synonym: Soda, Caustic
Synonym: Sodium Hydroxide [Chemical/Ingredient]
Synonym: Sodium hydroxide
Synonym: Sodium hydroxide (Na(OH))
Synonym: Sodium hydroxide (substance)
Tree Number: T6.1.2.2.5
Tree Number: T6.1.31.5
database_cross_reference: AOD:0000019576
database_cross_reference: CHV:0000011492
database_cross_reference: DRUGBANK:DB11151
database_cross_reference: LCH:U004376
database_cross_reference: LCH_NW:sh85124265
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D012972
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:55X04QC32I
database_cross_reference: NCI:C74373
database_cross_reference: NCI_FDA:55X04QC32I
database_cross_reference: NDDF:001962
database_cross_reference: NDFRT:N0000007231
database_cross_reference: NDFRT:N0000146255
database_cross_reference: RCD:Xa0UK
database_cross_reference: RXNORM:9880
database_cross_reference: SNM:E-5031
database_cross_reference: SNMI:C-10310
database_cross_reference: SNOMEDCT_US:23423003
database_cross_reference: VANDF:4017904

Water
type: Class
subclass of: Hydroxides
subclass of: Oxides
PMOID: PMO:00015195
Subclass_of: Hydroxides
Subclass_of: Oxides
Synonym: Dihydrogen oxide
Synonym: H2O - Water
Synonym: Hydrogen Oxide
Synonym: WATER
Synonym: Water (substance)
Synonym: Water [Chemical/Ingredient]
Synonym: Water product
Synonym: Water product (product)
Synonym: Water product (substance)
Synonym: Watering
Tree Number: T6.1.18.1.12
Tree Number: T6.1.2.2.6
database_cross_reference: AOD:0000001140
database_cross_reference: CHV:0000013112
database_cross_reference: CSP:3156-9415
database_cross_reference: DRUGBANK:DB09145
database_cross_reference: LCH:U005007
database_cross_reference: LCH_NW:sh85145447
database_cross_reference: LNC:LA14387-7
database_cross_reference: LNC:LA16273-7
database_cross_reference: LNC:LP35030-3
database_cross_reference: LNC:LP7719-0
database_cross_reference: LNC:LP99666-7
database_cross_reference: LNC:MTHU001475
database_cross_reference: LNC:MTHU036072
database_cross_reference: MEDLINEPLUS:1435
database_cross_reference: MSH:D014867
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:059QF0KO0R
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C65147
database_cross_reference: NCI_CRCH:C65147
database_cross_reference: NCI_FDA:059QF0KO0R
database_cross_reference: NDDF:000738
database_cross_reference: NDFRT:N0000006428
database_cross_reference: NDFRT:N0000147042
database_cross_reference: RCD:XM0ll
database_cross_reference: RCD:x00C7
database_cross_reference: RXNORM:11295
database_cross_reference: SNM:E-5015
database_cross_reference: SNMI:C-10120
database_cross_reference: SNOMEDCT_US:11713004
database_cross_reference: SNOMEDCT_US:346712003
database_cross_reference: VANDF:4018738

Hydroxyl Radical
type: Class
subclass of: Hydroxides
subclass of: Reactive Oxygen Species
PMOID: PMO:00015202
Subclass_of: Hydroxides
Subclass_of: Reactive Oxygen Species
Synonym: Hydroxyl
Synonym: Hydroxyl Radical [Chemical/Ingredient]
Synonym: OH
Synonym: hydroxyl
Synonym: hydroxyl radical
Tree Number: T6.1.2.2.7
Tree Number: T6.1.7.2.3
database_cross_reference: CHV:0000014191
database_cross_reference: CSP:4003-0025
database_cross_reference: MSH:D017665
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C1130
database_cross_reference: NDFRT:N0000166219

Ammonium Hydroxide
type: Class
subclass of: Hydroxides
subclass of: Ammonium Compounds
PMOID: PMO:00015203
Subclass_of: Ammonium Compounds
Subclass_of: Hydroxides
Synonym: AMMONIUM HYDROXIDE
Synonym: Ammonia water
Synonym: Ammonium Hydroxide [Chemical/Ingredient]
Synonym: Ammonium hydroxide
Synonym: Ammonium hydroxide (substance)
Synonym: Hydroxide, Ammonium
Synonym: ammonia water
Synonym: ammonium hydroxide
Tree Number: T6.1.2.2.8
Tree Number: T6.1.33.11.5
database_cross_reference: CHV:0000013480
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D064753
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NDDF:008846
database_cross_reference: NDFRT:N0000005888
database_cross_reference: NDFRT:N0000022628
database_cross_reference: RXNORM:1362884
database_cross_reference: SNM:E-5073
database_cross_reference: SNMI:C-10761
database_cross_reference: SNOMEDCT_US:76198002
database_cross_reference: VANDF:4020005

Lewis Bases
type: Class
subclass of: Alkalies
subclass of: Organic Chemicals
PMOID: PMO:00015204
Subclass_of: Alkalies
Subclass_of: Organic Chemicals
Synonym: Bases, Lewis
Synonym: Lewis Bases [Chemical/Ingredient]
Synonym: Lewis base
Tree Number: T6.1.2.3
Tree Number: T6.2.41
database_cross_reference: AOD:0000019568
database_cross_reference: MSH:D058115
database_cross_reference: NDFRT:N0000182067

Arsenicals
type: Class
subclass of: Inorganic Chemicals
subclass of: PMO:00017252
PMOID: PMO:00015205
Subclass_of: Inorganic Chemicals
Subclass_of: Organometallic Compounds
Synonym: ARSENIC CPDS
Synonym: Arsenic Compound
Synonym: Arsenic Compounds
Synonym: Arsenic compound
Synonym: Arsenic compound (substance)
Synonym: Arsenic compound, NOS
Synonym: Arsenic compounds
Synonym: Arsenicals [Chemical/Ingredient]
Synonym: Compounds, Arsenic
Synonym: arsenic compounds
Tree Number: T6.1.3
Tree Number: T6.2.28.5
database_cross_reference: CHV:0000001443
database_cross_reference: LCH_NW:sh85007453
database_cross_reference: MSH:D001152
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C45557
database_cross_reference: NDFRT:N0000008120
database_cross_reference: SNMI:C-11510
database_cross_reference: SNOMEDCT_US:23217006

Arsenates
type: Class
subclass of: Arsenicals
PMOID: PMO:00015206
Subclass_of: Arsenicals
Synonym: Arsenates [Chemical/Ingredient]
Tree Number: T6.1.3.1
Tree Number: T6.2.28.5.3
database_cross_reference: LCH:U000360
database_cross_reference: LCH_NW:sh85007448
database_cross_reference: MSH:D001149
database_cross_reference: NDFRT:N0000166776

Arsenites
type: Class
subclass of: Arsenicals
PMOID: PMO:00015207
Subclass_of: Arsenicals
Synonym: Arsenites [Chemical/Ingredient]
Tree Number: T6.1.3.2
Tree Number: T6.2.28.5.10
database_cross_reference: MSH:D018053
database_cross_reference: NDFRT:N0000166773

Boron Compounds
type: Class
subclass of: Inorganic Chemicals
subclass of: Organic Chemicals
PMOID: PMO:00015208
Subclass_of: Inorganic Chemicals
Subclass_of: Organic Chemicals
Synonym: BORON CPDS
Synonym: Boron Compounds [Chemical/Ingredient]
Synonym: Boron compound
Synonym: Boron compound (substance)
Synonym: Boron compound, NOS
Synonym: Boron compounds
Synonym: Compounds, Boron
Tree Number: T6.1.4
Tree Number: T6.2.11
database_cross_reference: LCH_NW:sh89002772
database_cross_reference: MSH:D001896
database_cross_reference: NDFRT:N0000008253
database_cross_reference: SNMI:C-10910
database_cross_reference: SNOMEDCT_US:11555005

Boranes
type: Class
subclass of: Boron Compounds
PMOID: PMO:00015209
Subclass_of: Boron Compounds
Synonym: Borane
Synonym: Boranes [Chemical/Ingredient]
Synonym: Boron Hydrides
Synonym: Hydrides, Boron
Synonym: borane
Tree Number: T6.1.4.1
Tree Number: T6.2.11.1
database_cross_reference: CSP:1852-7336
database_cross_reference: LCH:U000645
database_cross_reference: LCH_NW:sh90001883
database_cross_reference: MSH:D001880
database_cross_reference: NDFRT:N0000166854

Borohydrides
type: Class
subclass of: Boranes
PMOID: PMO:00015210
Subclass_of: Boranes
Synonym: Borohydrides [Chemical/Ingredient]
Synonym: borohydride
Tree Number: T6.1.4.1.1
Tree Number: T6.2.11.1.1
database_cross_reference: CSP:1852-7336
database_cross_reference: MSH:D001894
database_cross_reference: NDFRT:N0000166855

Borates
type: Class
subclass of: Boric Acids
PMOID: PMO:00015211
Subclass_of: Boric Acids
Synonym: Borate
Synonym: Borate product
Synonym: Borate product (product)
Synonym: Borate product (substance)
Synonym: Borate salt
Synonym: Borate salt (substance)
Synonym: Borates [Chemical/Ingredient]
Synonym: borate
Synonym: borated
Synonym: borates
Tree Number: T6.1.4.2.1
Tree Number: T6.2.11.2.1
database_cross_reference: CHV:0000002091
database_cross_reference: LCH:U000646
database_cross_reference: LCH_NW:sh85015805
database_cross_reference: LNC:LP14927-5
database_cross_reference: LNC:MTHU001846
database_cross_reference: MSH:D001881
database_cross_reference: NDFRT:N0000007027
database_cross_reference: RCD:x01Jw
database_cross_reference: SNM:E-5092
database_cross_reference: SNMI:C-10920
database_cross_reference: SNOMEDCT_US:34074001
database_cross_reference: SNOMEDCT_US:350267000

Electrolytes
type: Class
subclass of: Inorganic Chemicals
PMOID: PMO:00015212
Subclass_of: Inorganic Chemicals
Synonym: ELECTROLYTE
Synonym: ELECTROLYTES
Synonym: Electrolyte
Synonym: Electrolyte (substance)
Synonym: Electrolyte, NOS
Synonym: Electrolytes [Chemical/Ingredient]
Synonym: electrolyte
Synonym: electrolytes
Synonym: electrolytes (medication)
Tree Number: T6.1.5
database_cross_reference: ATC:B05BB01
database_cross_reference: CCPSS:0031473
database_cross_reference: CHV:0000004340
database_cross_reference: CSP:1627-0882
database_cross_reference: GS:44438
database_cross_reference: GS:44529
database_cross_reference: GS:44534
database_cross_reference: GS:44535
database_cross_reference: GS:44606
database_cross_reference: GS:79077
database_cross_reference: GS:79078
database_cross_reference: LCH:U001534
database_cross_reference: LCH_NW:sh85042157
database_cross_reference: LNC:LP19403-2
database_cross_reference: LNC:MTHU008531
database_cross_reference: MEDCIN:41197
database_cross_reference: MEDLINEPLUS:4224
database_cross_reference: MMSL:10465
database_cross_reference: MMSL:20358
database_cross_reference: MSH:D004573
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C464
database_cross_reference: NCI_NCI-GLOSS:CDR0000044338
database_cross_reference: NDFRT:N0000008272
database_cross_reference: NDFRT:N0000020495
database_cross_reference: PSY:16540
database_cross_reference: RCD:X80Cx
database_cross_reference: SNMI:C-10010
database_cross_reference: SNOMEDCT_US:86355000
database_cross_reference: VANDF:4022490

Polyelectrolytes
type: Class
subclass of: Electrolytes
subclass of: PMO:00018792
PMOID: PMO:00015213
Subclass_of: Electrolytes
Subclass_of: Polymers
Synonym: Polyelectrolytes [Chemical/Ingredient]
Tree Number: T6.1.5.1
Tree Number: T6.5.2.1
database_cross_reference: MSH:D000071228
database_cross_reference: NDFRT:N0000193173

Ions
type: Class
subclass of: Electrolytes
PMOID: PMO:00015214
Subclass_of: Electrolytes
Synonym: Ion
Synonym: Ion (substance)
Synonym: Ion, NOS
Synonym: Ions [Chemical/Ingredient]
Synonym: charged particles
Synonym: ion
Synonym: ions
Tree Number: T6.1.5.2
database_cross_reference: AOD:0000001096
database_cross_reference: AOD:0000021453
database_cross_reference: CHV:0000006908
database_cross_reference: CSP:1626-5132
database_cross_reference: LCH:U002504
database_cross_reference: LCH_NW:sh85067842
database_cross_reference: MSH:D007477
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C597
database_cross_reference: NCI_NCI-GLOSS:CDR0000643017
database_cross_reference: NDFRT:N0000008197
database_cross_reference: PSY:26580
database_cross_reference: RCD:XM0Eo
database_cross_reference: SNM:F-10020
database_cross_reference: SNMI:C-10001
database_cross_reference: SNOMEDCT_US:48006008

Anions
type: Class
subclass of: Ions
PMOID: PMO:00015215
Subclass_of: Ions
Synonym: Anion
Synonym: Anion (substance)
Synonym: Anions [Chemical/Ingredient]
Synonym: anion
Synonym: anions
Synonym: negatively charged particle
Tree Number: T6.1.5.2.1
database_cross_reference: AOD:0000001097
database_cross_reference: AOD:0000021455
database_cross_reference: CHV:0000001210
database_cross_reference: CSP:1626-7005
database_cross_reference: LCH:U000256
database_cross_reference: LCH_NW:sh85005295
database_cross_reference: MSH:D000838
database_cross_reference: NDFRT:N0000007541
database_cross_reference: RCD:Xa4gK
database_cross_reference: SNMI:C-10003
database_cross_reference: SNOMEDCT_US:47707009

Bromates
type: Class
subclass of: Bromine Compounds
PMOID: PMO:00015216
Subclass_of: Bromine Compounds
Synonym: Bromate
Synonym: Bromates [Chemical/Ingredient]
Synonym: bromate
Tree Number: T6.1.19.1
database_cross_reference: CHV:0000002168
database_cross_reference: LCH:U000682
database_cross_reference: LCH_NW:sh85017042
database_cross_reference: MMSL:9917
database_cross_reference: MSH:D001959
database_cross_reference: NDFRT:N0000166197
database_cross_reference: RXNORM:1748

Bromides
type: Class
subclass of: Hydrobromic Acid
PMOID: PMO:00015217
Subclass_of: Hydrobromic Acid
Synonym: Bromide
Synonym: Bromide salt
Synonym: Bromide salt (substance)
Synonym: Bromide salt, NOS
Synonym: Bromide, NOS
Synonym: Bromides [Chemical/Ingredient]
Synonym: br
Synonym: bromide
Synonym: bromide (Br)
Synonym: bromide salts
Tree Number: T6.1.19.2.1
database_cross_reference: ATC:N05CM11
database_cross_reference: CHV:0000002172
database_cross_reference: LCH:U000684
database_cross_reference: LCH_NW:sh85017050
database_cross_reference: LNC:LP14091-0
database_cross_reference: LNC:MTHU005164
database_cross_reference: MMSL:46577
database_cross_reference: MSH:D001965
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:001426
database_cross_reference: NDFRT:N0000166198
database_cross_reference: PSY:06990
database_cross_reference: RCD:X794y
database_cross_reference: SNM:E-5107
database_cross_reference: SNMI:C-11320
database_cross_reference: SNOMEDCT_US:16624005

Chlorates
type: Class
subclass of: Chlorine Compounds
PMOID: PMO:00015219
Subclass_of: Chlorine Compounds
Synonym: Chlorate
Synonym: Chlorates [Chemical/Ingredient]
Synonym: chlorate
Synonym: chlorates
Tree Number: T6.1.20.2
database_cross_reference: CHV:0000002816
database_cross_reference: LCH:U000967
database_cross_reference: LCH_NW:sh85024526
database_cross_reference: LNC:LP18050-2
database_cross_reference: LNC:MTHU003042
database_cross_reference: MSH:D002704
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166286

Chlorides
type: Class
subclass of: Hydrochloric Acid
PMOID: PMO:00015220
Subclass_of: Hydrochloric Acid
Synonym: Chloride
Synonym: Chloride salt
Synonym: Chloride salt (substance)
Synonym: Chloride salt, NOS
Synonym: Chloride, NOS
Synonym: Chlorides [Chemical/Ingredient]
Synonym: chloride salt
Synonym: chlorides
Tree Number: T6.1.20.4.1
database_cross_reference: AOD:0000002431
database_cross_reference: CHV:0000002823
database_cross_reference: LCH:U000971
database_cross_reference: LCH_NW:sh85024536
database_cross_reference: MSH:D002712
database_cross_reference: MTH:U000240
database_cross_reference: MTH:U001804
database_cross_reference: NDFRT:N0000007711
database_cross_reference: RCD:X80D1
database_cross_reference: SNM:E-5105
database_cross_reference: SNMI:C-11220
database_cross_reference: SNOMEDCT_US:50213009

Chromates
type: Class
subclass of: Chromium Compounds
PMOID: PMO:00015221
Subclass_of: Chromium Compounds
Synonym: CHROMATES
Synonym: Chromate
Synonym: Chromates [Chemical/Ingredient]
Synonym: chromate
Synonym: chromated
Synonym: chromates
Tree Number: T6.1.22.1
database_cross_reference: CHV:0000002924
database_cross_reference: LNC:LP30820-2
database_cross_reference: LNC:MTHU015325
database_cross_reference: MSH:D002840
database_cross_reference: NDFRT:N0000007919
database_cross_reference: NDFRT:N0000176169
database_cross_reference: VANDF:4027809

Cyanides
type: Class
subclass of: Hydrogen Cyanide
PMOID: PMO:00015222
Subclass_of: Hydrogen Cyanide
Synonym: Cyanide
Synonym: Cyanide (substance)
Synonym: Cyanides [Chemical/Ingredient]
Synonym: cyanide
Synonym: cyanides
Tree Number: T6.1.33.5.1
database_cross_reference: AOD:0000019601
database_cross_reference: CHV:0000003514
database_cross_reference: CSP:0774-4855
database_cross_reference: LCH:U001226
database_cross_reference: LCH_NW:sh85035028
database_cross_reference: LNC:LP16815-0
database_cross_reference: LNC:MTHU009326
database_cross_reference: MSH:D003486
database_cross_reference: MTH:U001836
database_cross_reference: NDFRT:N0000008185
database_cross_reference: RCD:X807f
database_cross_reference: SNOMEDCT_US:259102005

Ferricyanides
type: Class
subclass of: Ferric Compounds
PMOID: PMO:00015223
Subclass_of: Ferric Compounds
Synonym: Ferricyanides [Chemical/Ingredient]
Synonym: ferricyanide
Tree Number: T6.1.49.1.1
database_cross_reference: AOD:0000019606
database_cross_reference: CHV:0000004973
database_cross_reference: MSH:D005292
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007756

Ferrocyanides
type: Class
subclass of: Ferrous Compounds
PMOID: PMO:00015225
Subclass_of: Ferrous Compounds
Synonym: Ferrocyanides [Chemical/Ingredient]
Tree Number: T6.1.49.2.1
database_cross_reference: LCH:U001763
database_cross_reference: LCH_NW:sh85047876
database_cross_reference: MSH:D005295
database_cross_reference: NDFRT:N0000011441

Fluorides
type: Class
subclass of: Hydrofluoric Acid
PMOID: PMO:00015226
Subclass_of: Hydrofluoric Acid
Synonym: F-
Synonym: FLUORIDE
Synonym: FLUORIDE ION
Synonym: Fluoride
Synonym: Fluoride (substance)
Synonym: Fluoride Ion
Synonym: Fluoride ion
Synonym: Fluoride preparation
Synonym: Fluoride product
Synonym: Fluoride product (product)
Tree Number: T6.1.25.1.1
database_cross_reference: AOD:0000019580
database_cross_reference: CHV:0000005120
database_cross_reference: DRUGBANK:DB09325
database_cross_reference: DRUGBANK:DB09484
database_cross_reference: DRUGBANK:DB11257
database_cross_reference: LCH:U001828
database_cross_reference: LCH_NW:sh85049419
database_cross_reference: LNC:LP16818-4
database_cross_reference: LNC:MTHU003484
database_cross_reference: MMSL:4741
database_cross_reference: MMSL:d00428
database_cross_reference: MSH:D005459
database_cross_reference: MTH:U001930
database_cross_reference: NCI:C28149
database_cross_reference: NCI_CRCH:C28149
database_cross_reference: NCI_FDA:Q80VPU408O
database_cross_reference: NCI_NCI-GLOSS:CDR0000044670
database_cross_reference: NDDF:001102
database_cross_reference: NDFRT:N0000007067
database_cross_reference: NDFRT:N0000146047
database_cross_reference: RCD:Xa4gR
database_cross_reference: RCD:x01QE
database_cross_reference: SNM:E-5101
database_cross_reference: SNM:F-10280
database_cross_reference: SNMI:C-11111
database_cross_reference: SNOMEDCT_US:260778008
database_cross_reference: SNOMEDCT_US:290007002
database_cross_reference: SNOMEDCT_US:350594000
database_cross_reference: SNOMEDCT_US:372639009
database_cross_reference: SNOMEDCT_US:387415009
database_cross_reference: SNOMEDCT_US:73550007
database_cross_reference: USPMG:MTHU001738
database_cross_reference: VANDF:4017671

Iodates
type: Class
subclass of: Iodine Compounds
PMOID: PMO:00015227
Subclass_of: Iodine Compounds
Synonym: Iodates [Chemical/Ingredient]
Synonym: iodate
Synonym: iodates
Tree Number: T6.1.27.1
database_cross_reference: CHV:0000006896
database_cross_reference: LCH:U002495
database_cross_reference: LCH_NW:sh85067767
database_cross_reference: MSH:D007452
database_cross_reference: NDFRT:N0000166190

Iodides
type: Class
subclass of: Iodine Compounds
PMOID: PMO:00015228
Subclass_of: Iodine Compounds
Synonym: I - Iodide
Synonym: I-
Synonym: Iodide
Synonym: Iodide salt
Synonym: Iodide salt (substance)
Synonym: Iodide salt, NOS
Synonym: Iodide, NOS
Synonym: Iodides [Chemical/Ingredient]
Synonym: Iodine-
Synonym: iodide
Tree Number: T6.1.27.2
database_cross_reference: AOD:0000019582
database_cross_reference: CHV:0000006898
database_cross_reference: DRUGBANK:DB12754
database_cross_reference: LCH:U002496
database_cross_reference: LCH_NW:sh85067768
database_cross_reference: LNC:LP36777-8
database_cross_reference: LNC:MTHU020182
database_cross_reference: MMSL:5877
database_cross_reference: MMSL:7443
database_cross_reference: MSH:D007454
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C68255
database_cross_reference: NCI_CRCH:C68255
database_cross_reference: NDFRT:N0000007779
database_cross_reference: RCD:X80RF
database_cross_reference: SNMI:C-11420
database_cross_reference: SNOMEDCT_US:42146005

Nitrates
type: Class
subclass of: Nitric Acid
subclass of: Organic Chemicals
PMOID: PMO:00015229
Subclass_of: Nitric Acid
Subclass_of: Organic Chemicals
Synonym: Nitrate
Synonym: Nitrate salt
Synonym: Nitrate salt (substance)
Synonym: Nitrate salt, NOS
Synonym: Nitrates [Chemical/Ingredient]
Synonym: nitrate salts
Synonym: nitrates
Tree Number: T6.1.33.9.1
Tree Number: T6.2.22
database_cross_reference: AOD:0000018481
database_cross_reference: CHV:0000008730
database_cross_reference: LCH:U003239
database_cross_reference: LCH_NW:sh85092042
database_cross_reference: LNC:LP14269-2
database_cross_reference: LNC:MTHU003455
database_cross_reference: MSH:D009566
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C80487
database_cross_reference: NDDF:000693
database_cross_reference: NDFRT:N0000007647
database_cross_reference: RCD:Xa0ib
database_cross_reference: SNM:E-5078
database_cross_reference: SNMI:C-10740
database_cross_reference: SNOMEDCT_US:89119000

Nitrites
type: Class
subclass of: Nitrous Acid
subclass of: Organic Chemicals
PMOID: PMO:00015230
Subclass_of: Nitrous Acid
Subclass_of: Organic Chemicals
Synonym: Nitrite
Synonym: Nitrite salt
Synonym: Nitrite salt (substance)
Synonym: Nitrite salt, NOS
Synonym: Nitrites [Chemical/Ingredient]
Synonym: nitrite
Synonym: nitrites
Tree Number: T6.1.33.7.1
Tree Number: T6.2.24
database_cross_reference: AOD:0000018483
database_cross_reference: CHV:0000008735
database_cross_reference: CSP:2073-7856
database_cross_reference: DRUGBANK:DB12529
database_cross_reference: LCH:U003243
database_cross_reference: LCH_NW:sh85092056
database_cross_reference: MSH:D009573
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007649
database_cross_reference: SNM:E-5077
database_cross_reference: SNMI:C-10731
database_cross_reference: SNOMEDCT_US:31528005

Oxides
type: Class
subclass of: Oxygen Compounds
PMOID: PMO:00015231
Subclass_of: Oxygen Compounds
Synonym: Oxides (substance)
Synonym: Oxides [Chemical/Ingredient]
Synonym: oxide
Synonym: oxides
Tree Number: T6.1.18.1
database_cross_reference: AOD:0000019609
database_cross_reference: CHV:0000009146
database_cross_reference: CSP:2165-9372
database_cross_reference: LCH:U003422
database_cross_reference: LCH_NW:sh85096314
database_cross_reference: MSH:D010087
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007842
database_cross_reference: RCD:XM0Ee
database_cross_reference: SNOMEDCT_US:272156001

Peroxides
type: Class
subclass of: Oxides
subclass of: Free Radicals
subclass of: Reactive Oxygen Species
PMOID: PMO:00015232
Subclass_of: Free Radicals
Subclass_of: Oxides
Subclass_of: Reactive Oxygen Species
Synonym: PEROXIDE
Synonym: Peroxide
Synonym: Peroxide (substance)
Synonym: Peroxides [Chemical/Ingredient]
Synonym: peroxide
Synonym: peroxides
Tree Number: T6.1.18.1.8
Tree Number: T6.1.7.2.2
Tree Number: T6.2.15.1
database_cross_reference: AOD:0000019631
database_cross_reference: CCPSS:0044542
database_cross_reference: CHV:0000009537
database_cross_reference: CSP:2251-5333
database_cross_reference: LCH:U003576
database_cross_reference: LCH_NW:sh85100033
database_cross_reference: MSH:D010545
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000008023
database_cross_reference: SNOMEDCT_US:418339008

Hydrogen Peroxide
type: Class
subclass of: Peroxides
PMOID: PMO:00015233
Subclass_of: Peroxides
Synonym: 3% Hydrogen Peroxide Well at Walgreens
Synonym: Aplicare Hydrogen Peroxide
Synonym: Blossom HP 3
Synonym: CURAD Hydrogen Peroxide
Synonym: DOP Hydrogen Peroxide 3%
Synonym: Dihydrogen Dioxide
Synonym: Dihydrogen Peroxide
Synonym: Dio Whitening
Synonym: Dynarex HP 3
Synonym: ECOLAB Hydrogen Peroxide
Tree Number: T6.2.15.1.1
database_cross_reference: ATC:A01AB02
database_cross_reference: ATC:D08AX01
database_cross_reference: ATC:S02AA06
database_cross_reference: CHV:0000006356
database_cross_reference: CSP:2251-6269
database_cross_reference: DRUGBANK:DB11091
database_cross_reference: LCH:U002279
database_cross_reference: LCH_NW:sh85063431
database_cross_reference: MEDCIN:309056
database_cross_reference: MEDCIN:41345
database_cross_reference: MMSL:35389
database_cross_reference: MMSL:35390
database_cross_reference: MMSL:4847
database_cross_reference: MMSL:5359
database_cross_reference: MSH:D006861
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:BBX060AN9V
database_cross_reference: NCI:C28156
database_cross_reference: NCI_DCP:00829
database_cross_reference: NCI_FDA:BBX060AN9V
database_cross_reference: NCI_NCI-GLOSS:CDR0000044113
database_cross_reference: NDDF:003157
database_cross_reference: NDFRT:N0000006490
database_cross_reference: NDFRT:N0000147686
database_cross_reference: RCD:XM0lZ
database_cross_reference: RCD:le4..
database_cross_reference: RCD:mib..
database_cross_reference: RCD:x02Mb
database_cross_reference: RXNORM:5499
database_cross_reference: SNM:E-7116
database_cross_reference: SNMI:C-96010
database_cross_reference: SNOMEDCT_US:273956008
database_cross_reference: SNOMEDCT_US:31231007
database_cross_reference: SNOMEDCT_US:331301001
database_cross_reference: SNOMEDCT_US:333301006
database_cross_reference: SNOMEDCT_US:387171003
database_cross_reference: VANDF:4019590

Lipid Peroxides
type: Class
subclass of: Peroxides
subclass of: PMO:00021062
PMOID: PMO:00015234
Subclass_of: Lipids
Subclass_of: Peroxides
Synonym: Acid Hydroperoxides, Fatty
Synonym: Fatty Acid Hydroperoxides
Synonym: HO2R
Synonym: Hydroperoxide, Lipid
Synonym: Hydroperoxides, Fatty Acid
Synonym: LOOH
Synonym: LPO
Synonym: Lipid Hydroperoxide
Synonym: Lipid Peroxides [Chemical/Ingredient]
Synonym: Lipoperoxides
Tree Number: T6.2.15.1.2
Tree Number: T6.9.7
database_cross_reference: CHV:0000007453
database_cross_reference: CSP:1744-1137
database_cross_reference: MSH:D008054
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C124072
database_cross_reference: NDFRT:N0000168561

Prostaglandin Endoperoxides
type: Class
subclass of: Peroxides
PMOID: PMO:00015235
Subclass_of: Peroxides
Synonym: Endoperoxides, Prostaglandin
Synonym: PG ENDOPEROXIDES
Synonym: Prostaglandin Endoperoxides [Chemical/Ingredient]
Synonym: prostaglandin endoperoxide
Tree Number: T6.2.15.1.3
database_cross_reference: AOD:0000020053
database_cross_reference: MSH:D011449
database_cross_reference: NDFRT:N0000171026

Superoxides
type: Class
subclass of: Peroxides
PMOID: PMO:00015240
Subclass_of: Peroxides
Synonym: Superoxide
Synonym: Superoxide Anion
Synonym: Superoxide Radical
Synonym: Superoxides [Chemical/Ingredient]
Synonym: superoxide
Synonym: superoxide anion
Synonym: superoxide radical
Tree Number: T6.2.15.1.4
database_cross_reference: AOD:0000001291
database_cross_reference: AOD:0000001292
database_cross_reference: CHV:0000011894
database_cross_reference: CSP:2166-1558
database_cross_reference: LCH:U004530
database_cross_reference: LCH_NW:sh85130640
database_cross_reference: MSH:D013481
database_cross_reference: NCI:C852
database_cross_reference: NDFRT:N0000166189

tert-Butylhydroperoxide
type: Class
subclass of: Peroxides
PMOID: PMO:00015241
Subclass_of: Peroxides
Synonym: BUTYL HYDROPEROXIDE T
Synonym: Hydroperoxide, 1,1-dimethylethyl
Synonym: Hydroperoxide, t-Butyl
Synonym: Hydroperoxide, tert-Butyl
Synonym: t Butyl Hydroperoxide
Synonym: t Butylhydroperoxide
Synonym: t-Butyl Hydroperoxide
Synonym: t-Butylhydroperoxide
Synonym: tert Butyl Hydroperoxide
Synonym: tert Butylhydroperoxide
Tree Number: T6.2.15.1.5
database_cross_reference: MSH:D020122
database_cross_reference: NDFRT:N0000166626

Artemisinins
type: Class
subclass of: Peroxides
PMOID: PMO:00015242
Subclass_of: Peroxides
Synonym: Artemisinin
Synonym: Artemisinins [Chemical/Ingredient]
Synonym: artemisinins
Tree Number: T6.2.15.1.6
database_cross_reference: CHV:0000054942
database_cross_reference: DRUGBANK:DB13132
database_cross_reference: LCH_NW:sh2007003203
database_cross_reference: MSH:D037621
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166625

Tetraoxanes
type: Class
subclass of: Peroxides
PMOID: PMO:00015243
Subclass_of: Peroxides
Tree Number: T6.2.15.1.7

Sulfides
type: Class
subclass of: Hydrogen Sulfide
subclass of: Sulfur Compounds
PMOID: PMO:00015246
Subclass_of: Hydrogen Sulfide
Subclass_of: Sulfur Compounds
Synonym: Sulfide
Synonym: Sulfide (substance)
Synonym: Sulfides [Chemical/Ingredient]
Synonym: Sulphide
Synonym: sulfide
Synonym: sulfides
Synonym: sulphide
Synonym: sulphides
Tree Number: T6.1.13.1.1
Tree Number: T6.2.32.7
database_cross_reference: AOD:0000019638
database_cross_reference: CHV:0000011862
database_cross_reference: CSP:2837-0331
database_cross_reference: LCH_NW:sh85130342
database_cross_reference: LNC:LP17951-2
database_cross_reference: LNC:MTHU007719
database_cross_reference: MSH:D013440
database_cross_reference: NDFRT:N0000008042
database_cross_reference: SNOMEDCT_US:116252005

Disulfides
type: Class
subclass of: Sulfides
PMOID: PMO:00015247
Subclass_of: Sulfides
Synonym: Disulfides [Chemical/Ingredient]
Synonym: disulfide
Synonym: disulfides
Tree Number: T6.2.32.7.1
database_cross_reference: CHV:0000004041
database_cross_reference: MSH:D004220
database_cross_reference: NDFRT:N0000007877

Cystine
type: Class
subclass of: PMO:00021283
subclass of: PMO:00021298
PMOID: PMO:00015248
Subclass_of: Amino Acids, Diamino
Subclass_of: Amino Acids, Dicarboxylic
Synonym: (2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoic acid)
Synonym: (R,R)-3,3'-dithiobis(2-aminopropanoic acid)
Synonym: (R-(R*,R*))-3,3'-Dithiobis(2-Aminopropanoic Acid)
Synonym: 1-Cystine
Synonym: 3,3'-Dithiobis(2-Aminopropanoic Acid)
Synonym: 3,3'-Dithiobis(2-Aminopropanoic Acid), (R-(R*,R*))-
Synonym: 3,3'-Dithiodialanine
Synonym: Alanine, 3,3'-Dithiobis-
Synonym: Alanine, 3,3'-Dithiodi-
Synonym: Beta,Beta'-Diamino-Beta,Beta'-Dicarboxydiethyl Disulfide
Tree Number: T6.10.1.5.5
Tree Number: T6.10.1.6.4
database_cross_reference: AOD:0000020257
database_cross_reference: CHV:0000003555
database_cross_reference: CSP:2842-7411
database_cross_reference: DRUGBANK:DB00138
database_cross_reference: LNC:LP14976-2
database_cross_reference: LNC:MTHU004102
database_cross_reference: MEDCIN:199253
database_cross_reference: MMSL:4525
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D003553
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:48TCX9A1VT
database_cross_reference: NCI:C29610
database_cross_reference: NCI_DCP:02778
database_cross_reference: NCI_FDA:48TCX9A1VT
database_cross_reference: NDDF:005113
database_cross_reference: NDFRT:N0000006059
database_cross_reference: NDFRT:N0000147293
database_cross_reference: RCD:X807F
database_cross_reference: RCD:XaDdK
database_cross_reference: RXNORM:3036
database_cross_reference: SNM:F-14390
database_cross_reference: SNMI:F-64190
database_cross_reference: SNOMEDCT_US:312174006
database_cross_reference: SNOMEDCT_US:37927000
database_cross_reference: VANDF:4019019

Sulfites
type: Class
subclass of: Sulfur Compounds
PMOID: PMO:00015249
Subclass_of: Sulfur Compounds
Synonym: INORG SULFITES
Synonym: Inorganic Sulfites
Synonym: SULFITES INORG
Synonym: Sulfite
Synonym: Sulfite salt
Synonym: Sulfite salt (substance)
Synonym: Sulfite salt, NOS
Synonym: Sulfites [Chemical/Ingredient]
Synonym: Sulfites, Inorganic
Synonym: Sulphite
Tree Number: T6.1.13.2
database_cross_reference: AOD:0000018504
database_cross_reference: CHV:0000011865
database_cross_reference: CSP:2838-5315
database_cross_reference: LNC:LP99342-5
database_cross_reference: LNC:MTHU035518
database_cross_reference: MSH:D013447
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:006300
database_cross_reference: NDFRT:N0000008046
database_cross_reference: RCD:X80MA
database_cross_reference: RCDAE:X80MA
database_cross_reference: SNM:E-5087
database_cross_reference: SNMI:C-10831
database_cross_reference: SNOMEDCT_US:51963001

Dithionite
type: Class
subclass of: Sulfites
PMOID: PMO:00015250
Subclass_of: Sulfites
Synonym: Dithionite [Chemical/Ingredient]
Synonym: Hyposulfite
Tree Number: T6.1.13.2.1
database_cross_reference: MSH:D004227
database_cross_reference: NDFRT:N0000166207

Vanadates
type: Class
subclass of: Vanadium Compounds
PMOID: PMO:00015251
Subclass_of: Vanadium Compounds
Synonym: Vanadate
Synonym: Vanadates [Chemical/Ingredient]
Synonym: vanadate
Tree Number: T6.1.38.1
database_cross_reference: CHV:0000012889
database_cross_reference: CSP:1852-9180
database_cross_reference: LCH:U004893
database_cross_reference: LCH_NW:sh85142004
database_cross_reference: MSH:D014638
database_cross_reference: NDFRT:N0000166279

Cations
type: Class
subclass of: Ions
PMOID: PMO:00015253
Subclass_of: Ions
Synonym: Cation
Synonym: Cation (substance)
Synonym: Cations [Chemical/Ingredient]
Synonym: cation
Synonym: cations
Synonym: positively charged particle
Tree Number: T6.1.5.2.2
database_cross_reference: AOD:0000001098
database_cross_reference: AOD:0000021457
database_cross_reference: CHV:0000002541
database_cross_reference: CSP:1627-0751
database_cross_reference: LCH:U000850
database_cross_reference: LCH_NW:sh85021247
database_cross_reference: MSH:D002412
database_cross_reference: NDFRT:N0000166191
database_cross_reference: RCD:Xa4gJ
database_cross_reference: SNMI:C-10002
database_cross_reference: SNOMEDCT_US:31046007

Protons
type: Class
subclass of: Hydrogen
PMOID: PMO:00015256
Subclass_of: Hydrogen
Synonym: H+
Synonym: H+ element
Synonym: H^+^
Synonym: Hydrogen Ion
Synonym: Hydrogen Ions
Synonym: Hydrogen ion
Synonym: Ion, Hydrogen
Synonym: Ions, Hydrogen
Synonym: Proton
Tree Number: T6.1.6.5.2
Tree Number: T6.1.8.7.2
database_cross_reference: AOD:0000001091
database_cross_reference: CHV:0000010262
database_cross_reference: CSP:4007-0059
database_cross_reference: LCH:U003885
database_cross_reference: LCH_NW:sh85107796
database_cross_reference: LNC:LA4665-1
database_cross_reference: LNC:LP33343-2
database_cross_reference: LNC:MTHU016661
database_cross_reference: MSH:D011522
database_cross_reference: MTH:U002198
database_cross_reference: NCI:C17024
database_cross_reference: NCI_NCI-GLOSS:CDR0000044715
database_cross_reference: NDFRT:N0000166194
database_cross_reference: RCD:X79Of
database_cross_reference: SNM:E-9334
database_cross_reference: SNM:F-10300
database_cross_reference: SNMI:C-10005
database_cross_reference: SNOMEDCT_US:123228009
database_cross_reference: SNOMEDCT_US:89177007

Elements
type: Class
subclass of: Inorganic Chemicals
PMOID: PMO:00015257
Subclass_of: Inorganic Chemicals
Synonym: Chemical Elements
Synonym: Chemical element
Synonym: Chemical element (substance)
Synonym: Chemical element, NOS
Synonym: Chemical elements
Synonym: Element
Synonym: Element, NOS
Synonym: Element, chemical
Synonym: Elements [Chemical/Ingredient]
Synonym: chemical elements
Tree Number: T6.1.6
database_cross_reference: AOD:0000019447
database_cross_reference: CHV:0000004360
database_cross_reference: CSP:0631-2320
database_cross_reference: LCH:U005508
database_cross_reference: LCH_NW:sh85022897
database_cross_reference: MSH:D004602
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C1940
database_cross_reference: NCI_NCI-GLOSS:CDR0000613508
database_cross_reference: NDFRT:N0000007912
database_cross_reference: PSY:08550
database_cross_reference: RCD:XM0EY
database_cross_reference: SNM:E-5001
database_cross_reference: SNMI:C-10000
database_cross_reference: SNOMEDCT_US:57795002

Carbon
type: Class
subclass of: Elements
PMOID: PMO:00015258
Subclass_of: Elements
Synonym: C element
Synonym: Carbon (substance)
Synonym: Carbon [Chemical/Ingredient]
Synonym: Carbon, NOS
Synonym: Elemental Carbon
Synonym: carbon
Synonym: carbons
Tree Number: T6.1.6.1
database_cross_reference: AOD:0000001960
database_cross_reference: CHV:0000002391
database_cross_reference: CSP:0552-0356
database_cross_reference: CSP:4007-0020
database_cross_reference: DRUGBANK:DB09278
database_cross_reference: LCH:U000784
database_cross_reference: LCH_NW:sh85020090
database_cross_reference: MSH:D002244
database_cross_reference: NCI:C63798
database_cross_reference: NDFRT:N0000007500
database_cross_reference: PSY:07520
database_cross_reference: RCD:Xa1gj
database_cross_reference: SNM:E-5050
database_cross_reference: SNMI:C-10500
database_cross_reference: SNOMEDCT_US:87453002

Carbon Isotopes
type: Class
subclass of: Carbon
subclass of: Isotopes
PMOID: PMO:00015259
Subclass_of: Carbon
Subclass_of: Isotopes
Synonym: Carbon Isotopes [Chemical/Ingredient]
Synonym: Carbon isotope
Synonym: Carbon isotope (substance)
Synonym: Carbon--Isotopes
Synonym: Isotopes, Carbon
Tree Number: T6.1.6.1.1
Tree Number: T6.1.9.2
database_cross_reference: LCH_NW:sh85020091
database_cross_reference: MSH:D002247
database_cross_reference: NDFRT:N0000166117
database_cross_reference: SNMI:C-10501
database_cross_reference: SNOMEDCT_US:31947001

Carbon Radioisotopes
type: Class
subclass of: Carbon Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015260
Subclass_of: Carbon Isotopes
Subclass_of: Radioisotopes
Synonym: Carbon Radioisotopes [Chemical/Ingredient]
Synonym: Carbon radioisotope
Synonym: Carbon radioisotope (substance)
Synonym: Carbon radioisotope, NOS
Synonym: Radioisotopes, Carbon
Tree Number: T6.1.9.17.5
Tree Number: T6.1.9.2.1
database_cross_reference: MSH:D002250
database_cross_reference: NDFRT:N0000166118
database_cross_reference: SNM:E-5052
database_cross_reference: SNMI:C-105A0
database_cross_reference: SNOMEDCT_US:90355009

Charcoal
type: Class
subclass of: Carbon
PMOID: PMO:00015261
Subclass_of: Carbon
Synonym: CHARCOAL
Synonym: Charcoal [Chemical/Ingredient]
Synonym: charcoal
Tree Number: T6.1.6.1.2
database_cross_reference: CHV:0000002721
database_cross_reference: CSP:4007-0027
database_cross_reference: DRUGBANK:DB09278
database_cross_reference: LCH:U000926
database_cross_reference: LCH_NW:sh85022633
database_cross_reference: LNC:LA12905-8
database_cross_reference: LNC:LP65027-2
database_cross_reference: LNC:MTHU026680
database_cross_reference: MMSL:4402
database_cross_reference: MMSL:6014
database_cross_reference: MMSL:d01028
database_cross_reference: MSH:D002606
database_cross_reference: NDFRT:N0000005865
database_cross_reference: NDFRT:N0000147348
database_cross_reference: RXNORM:2296
database_cross_reference: VANDF:4019088

Graphite
type: Class
subclass of: Carbon
subclass of: Minerals
PMOID: PMO:00015262
Subclass_of: Carbon
Subclass_of: Minerals
Tree Number: T6.1.11.4
Tree Number: T6.1.6.1.3

Diamond
type: Class
subclass of: Carbon
PMOID: PMO:00015263
Subclass_of: Carbon
Synonym: DIAMOND
Synonym: Diamond (substance)
Synonym: Diamond [Chemical/Ingredient]
Synonym: Diamonds
Synonym: diamond
Synonym: diamonds
Tree Number: T6.1.6.1.4
database_cross_reference: CHV:0000013863
database_cross_reference: LCH_NW:sh85037566
database_cross_reference: MSH:D018130
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:6GRV67N0U2
database_cross_reference: NDFRT:N0000166169
database_cross_reference: RXNORM:1362686
database_cross_reference: SNMI:C-10504
database_cross_reference: SNOMEDCT_US:1726000

Fullerenes
type: Class
subclass of: Carbon
PMOID: PMO:00015265
Subclass_of: Carbon
Synonym: Buckminsterfullerene
Synonym: Buckminsterfullerenes
Synonym: Buckyball
Synonym: Buckyballs
Synonym: Fullerene
Synonym: Fullerene (substance)
Synonym: Fullerenes [Chemical/Ingredient]
Synonym: buckminsterfullerene
Synonym: buckyballs
Synonym: fullerene
Tree Number: T6.1.6.1.5
database_cross_reference: CHV:0000028025
database_cross_reference: LCH_NW:sh91005662
database_cross_reference: MSH:D037741
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C62382
database_cross_reference: NDFRT:N0000166167
database_cross_reference: SNMI:C-10505
database_cross_reference: SNOMEDCT_US:77433007

Elements, Radioactive
type: Class
subclass of: Elements
subclass of: Radioisotopes
PMOID: PMO:00015267
Subclass_of: Elements
Subclass_of: Radioisotopes
Synonym: Elements, Radioactive [Chemical/Ingredient]
Synonym: Elements, radioactive
Synonym: Radioactive Element
Synonym: Radioactive Elements
Tree Number: T6.1.6.2
Tree Number: T6.1.9.17.11
database_cross_reference: MSH:D004603
database_cross_reference: NCI:C465
database_cross_reference: NDFRT:N0000007913

Transactinide Series Elements
type: Class
subclass of: Elements, Radioactive
PMOID: PMO:00015268
Subclass_of: Elements, Radioactive
Tree Number: T6.1.6.2.1

Astatine
type: Class
subclass of: Elements, Radioactive
subclass of: Halogens
PMOID: PMO:00015269
Subclass_of: Elements, Radioactive
Subclass_of: Halogens
Synonym: Astatine [Chemical/Ingredient]
Synonym: astatine
Tree Number: T6.1.6.2.2
Tree Number: T6.1.6.4.1
database_cross_reference: AOD:0000019492
database_cross_reference: LCH:U000402
database_cross_reference: LCH_NW:sh85008844
database_cross_reference: MSH:D001246
database_cross_reference: NDFRT:N0000166178

Bismuth
type: Class
subclass of: Elements, Radioactive
subclass of: Metals, Heavy
PMOID: PMO:00015270
Subclass_of: Elements, Radioactive
Subclass_of: Metals, Heavy
Synonym: BISMUTH
Synonym: Bi
Synonym: Bi - Bismuth
Synonym: Bi element
Synonym: Bismuth (substance)
Synonym: Bismuth Metallicum
Synonym: Bismuth [Chemical/Ingredient]
Synonym: Bismuth, NOS
Synonym: bismuth
Tree Number: T6.1.10.6.6
Tree Number: T6.1.6.12.6
Tree Number: T6.1.6.2.3
database_cross_reference: AOD:0000019481
database_cross_reference: CHV:0000001935
database_cross_reference: CSP:1852-9415
database_cross_reference: DRUGBANK:DB01294
database_cross_reference: LCH:U000593
database_cross_reference: LCH_NW:sh85014436
database_cross_reference: LNC:LP16806-9
database_cross_reference: LNC:MTHU006824
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D001729
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:U015TT5I8H
database_cross_reference: NCI:C95193
database_cross_reference: NCI_FDA:U015TT5I8H
database_cross_reference: NDDF:001158
database_cross_reference: NDFRT:N0000007888
database_cross_reference: NDFRT:N0000148861
database_cross_reference: RCD:X794w
database_cross_reference: RXNORM:1599
database_cross_reference: SNMI:C-12500
database_cross_reference: SNOMEDCT_US:23172004
database_cross_reference: VANDF:4021482

Francium
type: Class
subclass of: Elements, Radioactive
subclass of: Metals, Alkali
subclass of: Metals, Heavy
PMOID: PMO:00015271
Subclass_of: Elements, Radioactive
Subclass_of: Metals, Alkali
Subclass_of: Metals, Heavy
Synonym: Francium [Chemical/Ingredient]
Synonym: francium
Tree Number: T6.1.10.3.2
Tree Number: T6.1.10.6.16
Tree Number: T6.1.6.12.16
Tree Number: T6.1.6.2.4
Tree Number: T6.1.6.6.2
database_cross_reference: AOD:0000019457
database_cross_reference: LCH:U001875
database_cross_reference: LCH_NW:sh85051541
database_cross_reference: MSH:D005605
database_cross_reference: NDFRT:N0000166246

Actinoid Series Elements
type: Class
subclass of: Elements, Radioactive
subclass of: Metals
PMOID: PMO:00015272
Subclass_of: Elements, Radioactive
Subclass_of: Metals
Synonym: Actinide Metals
Synonym: Actinides
Synonym: Actinoid Metals
Synonym: Actinoid Series Elements [Chemical/Ingredient]
Synonym: Actinoids
Synonym: Elements, Actinoid Series
Synonym: Metals, Actinide
Synonym: Metals, Actinoid
Synonym: actinide
Tree Number: T6.1.10.2
Tree Number: T6.1.6.2.5
database_cross_reference: CSP:2540-7596
database_cross_reference: MSH:D008671
database_cross_reference: NDFRT:N0000166223

Actinium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015273
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Ac element
Synonym: Actinium
Synonym: Actinium (substance)
Synonym: Actinium [Chemical/Ingredient]
Synonym: Actinium, NOS
Synonym: actinium
Tree Number: T6.1.10.2.1
Tree Number: T6.1.10.6.1
Tree Number: T6.1.6.12.1
database_cross_reference: CSP:2540-7596
database_cross_reference: DRUGBANK:DB00776
database_cross_reference: DRUGBANK:DB12860
database_cross_reference: LCH:U000049
database_cross_reference: LCH_NW:sh85000706
database_cross_reference: MSH:D000186
database_cross_reference: NDFRT:N0000166262
database_cross_reference: SNMI:C-11900
database_cross_reference: SNOMEDCT_US:1396009

Americium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015274
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: AMERICIUM
Synonym: Am
Synonym: Am element
Synonym: Americium (substance)
Synonym: Americium [Chemical/Ingredient]
Synonym: Americium, NOS
Synonym: Americum, NOS
Synonym: americium
Tree Number: T6.1.10.2.2
Tree Number: T6.1.10.6.2
Tree Number: T6.1.6.12.2
database_cross_reference: AOD:0000019554
database_cross_reference: CSP:2540-7689
database_cross_reference: LCH:U000186
database_cross_reference: LCH_NW:sh85004443
database_cross_reference: MSH:D000576
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C229
database_cross_reference: NCI_FDA:VW92PHU2UY
database_cross_reference: NDFRT:N0000166269
database_cross_reference: SNMI:C-17900
database_cross_reference: SNOMEDCT_US:88781006

Berkelium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015275
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Berkelium [Chemical/Ingredient]
Synonym: berkelium
Tree Number: T6.1.10.2.3
Tree Number: T6.1.10.6.5
Tree Number: T6.1.6.12.5
database_cross_reference: AOD:0000019556
database_cross_reference: DRUGBANK:DB12993
database_cross_reference: LCH_NW:sh2012004283
database_cross_reference: MSH:D001603
database_cross_reference: NDFRT:N0000166263

Californium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015276
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Californium (substance)
Synonym: Californium [Chemical/Ingredient]
Synonym: Californium, NOS
Synonym: californium
Tree Number: T6.1.10.2.4
Tree Number: T6.1.10.6.8
Tree Number: T6.1.6.12.8
database_cross_reference: AOD:0000019557
database_cross_reference: CSP:2540-7596
database_cross_reference: LCH_NW:sh89004338
database_cross_reference: MSH:D002142
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166252
database_cross_reference: SNMI:C-12400
database_cross_reference: SNOMEDCT_US:12292006

Curium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015277
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Curium (substance)
Synonym: Curium [Chemical/Ingredient]
Synonym: curium
Tree Number: T6.1.10.2.5
Tree Number: T6.1.10.6.13
Tree Number: T6.1.6.12.13
database_cross_reference: AOD:0000019555
database_cross_reference: LCH:U001223
database_cross_reference: LCH_NW:sh85034863
database_cross_reference: MSH:D003476
database_cross_reference: NDFRT:N0000166259
database_cross_reference: SNOMEDCT_US:416918003

Einsteinium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015278
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Einsteinium [Chemical/Ingredient]
Synonym: einsteinium
Tree Number: T6.1.10.2.6
Tree Number: T6.1.10.6.14
Tree Number: T6.1.6.12.14
database_cross_reference: AOD:0000019558
database_cross_reference: MSH:D004540
database_cross_reference: NDFRT:N0000166242

Fermium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015279
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Fermium [Chemical/Ingredient]
Synonym: fermium
Tree Number: T6.1.10.2.7
Tree Number: T6.1.10.6.15
Tree Number: T6.1.6.12.15
database_cross_reference: AOD:0000019559
database_cross_reference: LCH_NW:sh2012003995
database_cross_reference: MSH:D005286
database_cross_reference: NDFRT:N0000166271

Lawrencium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015280
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Lawrencium [Chemical/Ingredient]
Synonym: lawrencium
Tree Number: T6.1.10.2.8
Tree Number: T6.1.10.6.24
Tree Number: T6.1.6.12.24
Tree Number: T6.1.6.14.9
database_cross_reference: AOD:0000019562
database_cross_reference: DRUGBANK:DB12599
database_cross_reference: LCH:U002636
database_cross_reference: LCH_NW:sh85075345
database_cross_reference: MSH:D007852
database_cross_reference: NDFRT:N0000166245

Mendelevium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015281
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Mendelevium [Chemical/Ingredient]
Synonym: mendelevium
Tree Number: T6.1.10.2.9
Tree Number: T6.1.10.6.27
Tree Number: T6.1.6.12.27
database_cross_reference: AOD:0000019560
database_cross_reference: LCH_NW:sh2012003626
database_cross_reference: MSH:D008573
database_cross_reference: NDFRT:N0000166253

Neptunium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015282
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Neptunium [Chemical/Ingredient]
Synonym: neptunium
Tree Number: T6.1.10.2.10
Tree Number: T6.1.10.6.30
Tree Number: T6.1.6.12.30
database_cross_reference: AOD:0000019552
database_cross_reference: LCH:U003159
database_cross_reference: LCH_NW:sh85090879
database_cross_reference: MSH:D009405
database_cross_reference: NDFRT:N0000166248

Nobelium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015283
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Nobelium [Chemical/Ingredient]
Synonym: nobelium
Tree Number: T6.1.10.2.11
Tree Number: T6.1.10.6.33
Tree Number: T6.1.6.12.33
database_cross_reference: AOD:0000019561
database_cross_reference: LCH_NW:sh2012003649
database_cross_reference: MSH:D009614
database_cross_reference: NDFRT:N0000166258

Plutonium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015284
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: PLUTONIUM
Synonym: Plutonium (substance)
Synonym: Plutonium [Chemical/Ingredient]
Synonym: Plutonium, NOS
Synonym: Pu element
Synonym: plutonium
Tree Number: T6.1.10.2.12
Tree Number: T6.1.10.6.37
Tree Number: T6.1.6.12.37
database_cross_reference: AOD:0000019553
database_cross_reference: CHV:0000009859
database_cross_reference: CSP:2540-7947
database_cross_reference: LCH:U003726
database_cross_reference: LCH_NW:sh85103582
database_cross_reference: LNC:LP19200-2
database_cross_reference: LNC:MTHU007565
database_cross_reference: MSH:D011005
database_cross_reference: MTHSPL:53023GN24M
database_cross_reference: NDFRT:N0000166260
database_cross_reference: RCD:Xa9gB
database_cross_reference: RXNORM:1600135
database_cross_reference: SNMI:C-16100
database_cross_reference: SNOMEDCT_US:38327007

Protactinium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015285
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: Protactinium [Chemical/Ingredient]
Synonym: protactinium
Tree Number: T6.1.10.2.13
Tree Number: T6.1.10.6.38
Tree Number: T6.1.6.12.38
database_cross_reference: AOD:0000019549
database_cross_reference: LCH:U003872
database_cross_reference: LCH_NW:sh85107634
database_cross_reference: MSH:D011478
database_cross_reference: NDFRT:N0000166274

Thorium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015286
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: THORIUM
Synonym: Th - Thorium
Synonym: Thorium (substance)
Synonym: Thorium [Chemical/Ingredient]
Synonym: Thorium, NOS
Synonym: thorium
Tree Number: T6.1.10.2.14
Tree Number: T6.1.10.6.49
Tree Number: T6.1.6.12.49
database_cross_reference: AOD:0000019547
database_cross_reference: CHV:0000012215
database_cross_reference: LCH:U004664
database_cross_reference: LCH_NW:sh85134957
database_cross_reference: LNC:LP18154-2
database_cross_reference: LNC:MTHU003501
database_cross_reference: MSH:D013910
database_cross_reference: MTHSPL:60YU5MIG9W
database_cross_reference: NDFRT:N0000166249
database_cross_reference: RCD:Xa1gh
database_cross_reference: RXNORM:1534769
database_cross_reference: SNMI:C-15700
database_cross_reference: SNOMEDCT_US:7269004

Uranium
type: Class
subclass of: Actinoid Series Elements
subclass of: Metals, Heavy
PMOID: PMO:00015287
Subclass_of: Actinoid Series Elements
Subclass_of: Metals, Heavy
Synonym: U element
Synonym: URANIUM
Synonym: Uranium (substance)
Synonym: Uranium U-238
Synonym: Uranium [Chemical/Ingredient]
Synonym: Uranium, NOS
Synonym: Uranium, Natural
Synonym: uranium
Tree Number: T6.1.10.2.15
Tree Number: T6.1.10.6.52
Tree Number: T6.1.6.12.52
database_cross_reference: AOD:0000019548
database_cross_reference: CHV:0000012748
database_cross_reference: CSP:2540-8649
database_cross_reference: LCH:U004848
database_cross_reference: LCH_NW:sh85141276
database_cross_reference: LNC:LP16841-6
database_cross_reference: LNC:MTHU009462
database_cross_reference: MSH:D014501
database_cross_reference: MTH:U002336
database_cross_reference: MTHSPL:4OC371KSTK
database_cross_reference: NCI:C86020
database_cross_reference: NCI_FDA:4OC371KSTK
database_cross_reference: NDDF:006174
database_cross_reference: NDFRT:N0000166268
database_cross_reference: RXNORM:10999
database_cross_reference: SNMI:C-14000
database_cross_reference: SNOMEDCT_US:40584000

Polonium
type: Class
subclass of: Elements, Radioactive
subclass of: Chalcogens
subclass of: Metalloids
PMOID: PMO:00015288
Subclass_of: Chalcogens
Subclass_of: Elements, Radioactive
Subclass_of: Metalloids
Synonym: Polonium [Chemical/Ingredient]
Synonym: polonium
Tree Number: T6.1.6.11.2
Tree Number: T6.1.6.15.5
Tree Number: T6.1.6.2.6
database_cross_reference: AOD:0000019486
database_cross_reference: CHV:0000009900
database_cross_reference: LCH:U003749
database_cross_reference: LCH_NW:sh85104579
database_cross_reference: MSH:D011059
database_cross_reference: NDFRT:N0000166179

Promethium
type: Class
subclass of: Elements, Radioactive
PMOID: PMO:00015289
Subclass_of: Elements, Radioactive
Synonym: Promethium [Chemical/Ingredient]
Synonym: promethium
Tree Number: T6.1.6.2.7
database_cross_reference: AOD:0000019533
database_cross_reference: CHV:0000010180
database_cross_reference: LCH:U003855
database_cross_reference: LCH_NW:sh85107404
database_cross_reference: MSH:D011399
database_cross_reference: NDFRT:N0000166235

Radium
type: Class
subclass of: Elements, Radioactive
subclass of: Metals, Alkaline Earth
subclass of: Metals, Heavy
PMOID: PMO:00015290
Subclass_of: Elements, Radioactive
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Heavy
Synonym: Ra
Synonym: Radium (substance)
Synonym: Radium [Chemical/Ingredient]
Synonym: Radium, NOS
Synonym: radium
Tree Number: T6.1.10.4.3
Tree Number: T6.1.10.6.39
Tree Number: T6.1.6.12.39
Tree Number: T6.1.6.2.8
Tree Number: T6.1.6.7.5
database_cross_reference: AOD:0000019462
database_cross_reference: CHV:0000010556
database_cross_reference: LCH:U004036
database_cross_reference: LCH_NW:sh85110804
database_cross_reference: MSH:D011883
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C2391
database_cross_reference: NDFRT:N0000166243
database_cross_reference: RXNORM:1546450
database_cross_reference: SNMI:C-13600
database_cross_reference: SNOMEDCT_US:73469000

Radon
type: Class
subclass of: Elements, Radioactive
subclass of: Noble Gases
PMOID: PMO:00015291
Subclass_of: Elements, Radioactive
Subclass_of: Noble Gases
Synonym: RADON
Synonym: Radon (substance)
Synonym: Radon [Chemical/Ingredient]
Synonym: Radon, NOS
Synonym: Rn
Synonym: Rn element
Synonym: radon
Tree Number: T6.1.6.2.9
Tree Number: T6.1.6.3.5
Tree Number: T6.1.8.6.5
database_cross_reference: AOD:0000013602
database_cross_reference: CHV:0000010559
database_cross_reference: CSP:2548-0292
database_cross_reference: LCH:U004038
database_cross_reference: LCH_NW:sh85110814
database_cross_reference: MEDLINEPLUS:1443
database_cross_reference: MSH:D011886
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C800
database_cross_reference: NCI_FDA:Q74S4N8N1G
database_cross_reference: NCI_NCI-GLOSS:CDR0000046554
database_cross_reference: NDFRT:N0000166180
database_cross_reference: SNM:E-5204
database_cross_reference: SNMI:C-13650
database_cross_reference: SNOMEDCT_US:72927002

Technetium
type: Class
subclass of: Elements, Radioactive
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015293
Subclass_of: Elements, Radioactive
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: TC
Synonym: TECHNETIUM
Synonym: Tc element
Synonym: Technetium (substance)
Synonym: Technetium [Chemical/Ingredient]
Synonym: Technetium, NOS
Synonym: technetium
Tree Number: T6.1.10.6.47
Tree Number: T6.1.6.12.47
Tree Number: T6.1.6.14.25
Tree Number: T6.1.6.2.10
database_cross_reference: AOD:0000019512
database_cross_reference: CHV:0000012058
database_cross_reference: CSP:2550-0895
database_cross_reference: LCH:U004594
database_cross_reference: LCH_NW:sh85133086
database_cross_reference: LNC:LP57566-9
database_cross_reference: MSH:D013667
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000007138
database_cross_reference: NDFRT:N0000020228
database_cross_reference: SNMI:C-16300
database_cross_reference: SNOMEDCT_US:71789007
database_cross_reference: VANDF:4022222

Noble Gases
type: Class
subclass of: Elements
subclass of: Gases
PMOID: PMO:00015294
Subclass_of: Elements
Subclass_of: Gases
Synonym: 170-175 INERT GASES
Synonym: Elements, Group 18
Synonym: Gases, Inert
Synonym: Gases, Noble
Synonym: Gases, Rare
Synonym: Group 18 Elements
Synonym: INERT GASES
Synonym: Inert Gases
Synonym: Inert gas
Synonym: Inert gas (substance)
Tree Number: T6.1.6.3
Tree Number: T6.1.8.6
database_cross_reference: AOD:0000019495
database_cross_reference: CSP:1243-0936
database_cross_reference: LCH:U001919
database_cross_reference: LCH_NW:sh85053403
database_cross_reference: MSH:D005741
database_cross_reference: NDFRT:N0000007950
database_cross_reference: SNM:E-6680
database_cross_reference: SNM:U000150
database_cross_reference: SNMI:C-17000
database_cross_reference: SNOMEDCT_US:39769000

Argon
type: Class
subclass of: Noble Gases
PMOID: PMO:00015295
Subclass_of: Noble Gases
Synonym: 174 ARGON
Synonym: ARGON
Synonym: Ar element
Synonym: Argon (substance)
Synonym: Argon [Chemical/Ingredient]
Synonym: Argon, NOS
Synonym: argon
Tree Number: T6.1.6.3.1
Tree Number: T6.1.8.6.1
database_cross_reference: AOD:0000019498
database_cross_reference: CHV:0000001429
database_cross_reference: CSP:1243-1123
database_cross_reference: LCH:U000350
database_cross_reference: LCH_NW:sh85007108
database_cross_reference: LNC:LP101945-6
database_cross_reference: LNC:MTHU052448
database_cross_reference: MSH:D001128
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:67XQY1V3KH
database_cross_reference: NDFRT:N0000166175
database_cross_reference: RXNORM:1368133
database_cross_reference: SNMI:C-17400
database_cross_reference: SNOMEDCT_US:52503005

Helium
type: Class
subclass of: Noble Gases
PMOID: PMO:00015296
Subclass_of: Noble Gases
Synonym: 171 HELIUM
Synonym: Carbon Monox, Helium, Oxygen, Nitrogen L.D.M.
Synonym: Co-HE-O2-N2 Mixture
Synonym: Compressed Gas Oxidizing, N.O.S.
Synonym: Compressed Gas, N.O.S.
Synonym: Gaseous Inh Mixture 20% Oxygen 80% Helium
Synonym: HELIUM
Synonym: He
Synonym: He - Helium
Synonym: He element
Tree Number: T6.1.6.3.2
Tree Number: T6.1.8.6.2
database_cross_reference: AOD:0000019496
database_cross_reference: ATC:V03AN03
database_cross_reference: CHV:0000005922
database_cross_reference: CSP:1243-2996
database_cross_reference: DRUGBANK:DB09155
database_cross_reference: LCH:U002120
database_cross_reference: LCH_NW:sh85060043
database_cross_reference: LNC:LP101902-7
database_cross_reference: LNC:LP35985-8
database_cross_reference: LNC:MTHU052447
database_cross_reference: MMSL:d06862
database_cross_reference: MSH:D006371
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:206GF3GB41
database_cross_reference: NCI:C85242
database_cross_reference: NCI_FDA:206GF3GB41
database_cross_reference: NDDF:000716
database_cross_reference: NDFRT:N0000007123
database_cross_reference: NDFRT:N0000147379
database_cross_reference: PSY:22620
database_cross_reference: RCD:X799U
database_cross_reference: RXNORM:5140
database_cross_reference: SNMI:C-17100
database_cross_reference: SNOMEDCT_US:90317004
database_cross_reference: VANDF:4019128

Krypton
type: Class
subclass of: Noble Gases
PMOID: PMO:00015297
Subclass_of: Noble Gases
Synonym: 173 KRYPTON
Synonym: KRYPTON
Synonym: Krypton (substance)
Synonym: Krypton [Chemical/Ingredient]
Synonym: Krypton, NOS
Synonym: krypton
Tree Number: T6.1.6.3.3
Tree Number: T6.1.8.6.3
database_cross_reference: AOD:0000019499
database_cross_reference: CSP:1243-0936
database_cross_reference: LCH:U002592
database_cross_reference: LCH_NW:sh85073327
database_cross_reference: MSH:D007726
database_cross_reference: NDFRT:N0000166173
database_cross_reference: SNMI:C-17300
database_cross_reference: SNOMEDCT_US:12375004

Neon
type: Class
subclass of: Noble Gases
PMOID: PMO:00015298
Subclass_of: Noble Gases
Synonym: 175 NEON
Synonym: Co-NE-O2-N2 Mixture
Synonym: Lung Diffusion Test Mix No Ne Co
Synonym: NEON
Synonym: Ne element
Synonym: Neon (substance)
Synonym: Neon [Chemical/Ingredient]
Synonym: Neon, NOS
Synonym: neon
Tree Number: T6.1.6.3.4
Tree Number: T6.1.8.6.4
database_cross_reference: AOD:0000019497
database_cross_reference: CHV:0000008556
database_cross_reference: CSP:1243-6742
database_cross_reference: DRUGBANK:DB11589
database_cross_reference: LCH:U003150
database_cross_reference: LCH_NW:sh85090790
database_cross_reference: MSH:D009356
database_cross_reference: MTH:NOCODE
database_cross_reference: NDDF:000717
database_cross_reference: NDFRT:N0000166174
database_cross_reference: RXNORM:7301
database_cross_reference: SNMI:C-17500
database_cross_reference: SNOMEDCT_US:12112000

Xenon
type: Class
subclass of: Noble Gases
PMOID: PMO:00015299
Subclass_of: Noble Gases
Synonym: 172 XENON
Synonym: XENON
Synonym: Xe
Synonym: Xe - Xenon
Synonym: Xe element
Synonym: Xenon (substance)
Synonym: Xenon [Chemical/Ingredient]
Synonym: Xenon, NOS
Synonym: xenon
Synonym: xenon xe
Tree Number: T6.1.6.3.6
Tree Number: T6.1.8.6.6
database_cross_reference: AOD:0000007200
database_cross_reference: ATC:N01AX15
database_cross_reference: CHV:0000013231
database_cross_reference: CSP:1243-8625
database_cross_reference: DRUGBANK:DB09315
database_cross_reference: LCH:U005059
database_cross_reference: LCH_NW:sh85148790
database_cross_reference: LNC:LP188442-0
database_cross_reference: LNC:LP34323-3
database_cross_reference: LNC:MTHU052554
database_cross_reference: MMSL:192699
database_cross_reference: MSH:D014978
database_cross_reference: MTH:NOCODE
database_cross_reference: NCI:C85247
database_cross_reference: NCI_FDA:3H3U766W84
database_cross_reference: NDDF:000718
database_cross_reference: NDFRT:N0000007405
database_cross_reference: NDFRT:N0000147400
database_cross_reference: RCD:X90Er
database_cross_reference: RXNORM:11363
database_cross_reference: SNMI:C-17200
database_cross_reference: SNOMEDCT_US:83598005
database_cross_reference: VANDF:4019155

Xenon Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015300
Subclass_of: Isotopes
Synonym: Isotopes, Xenon
Synonym: Xenon Isotopes [Chemical/Ingredient]
Synonym: Xenon isotope
Synonym: Xenon isotope (substance)
Synonym: Xenon--Isotopes
Tree Number: T6.1.9.21
database_cross_reference: LCH_NW:sh85148791
database_cross_reference: MSH:D014979
database_cross_reference: NDFRT:N0000166129
database_cross_reference: SNMI:C-17201
database_cross_reference: SNOMEDCT_US:16745008

Xenon Radioisotopes
type: Class
subclass of: Xenon Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015301
Subclass_of: Radioisotopes
Subclass_of: Xenon Isotopes
Synonym: Radioisotopes, Xenon
Synonym: Xenon Radioisotopes [Chemical/Ingredient]
Synonym: Xenon radioisotope
Synonym: Xenon radioisotope (substance)
Synonym: Xenon radioisotope, NOS
Tree Number: T6.1.9.17.36
Tree Number: T6.1.9.21.1
database_cross_reference: MSH:D014980
database_cross_reference: NDFRT:N0000166130
database_cross_reference: SNMI:C-172A0
database_cross_reference: SNOMEDCT_US:44776005

Halogens
type: Class
subclass of: Elements
PMOID: PMO:00015302
Subclass_of: Elements
Synonym: Elements, Group 17
Synonym: Group 17 Elements
Synonym: Halogen
Synonym: Halogen (substance)
Synonym: Halogen, NOS
Synonym: Halogens [Chemical/Ingredient]
Synonym: halogen
Synonym: halogen elements
Synonym: halogens
Tree Number: T6.1.6.4
database_cross_reference: AOD:0000019488
database_cross_reference: CHV:0000005781
database_cross_reference: CSP:4000-0196
database_cross_reference: LCH:U002072
database_cross_reference: MSH:D006219
database_cross_reference: NDFRT:N0000007573
database_cross_reference: SNMI:C-11000
database_cross_reference: SNOMEDCT_US:28227002

Bromine
type: Class
subclass of: Halogens
PMOID: PMO:00015303
Subclass_of: Halogens
Synonym: BROMINE
Synonym: Br - Bromine
Synonym: Br element
Synonym: Br- element
Synonym: Bromine (substance)
Synonym: Bromine [Chemical/Ingredient]
Synonym: Bromine, NOS
Synonym: bromine
Tree Number: T6.1.6.4.2
database_cross_reference: AOD:0000019491
database_cross_reference: CHV:0000002173
database_cross_reference: CSP:1374-2377
database_cross_reference: LCH:U000685
database_cross_reference: LCH_NW:sh85017053
database_cross_reference: LNC:MTHU017569
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D001966
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:SBV4XY874G
database_cross_reference: NDFRT:N0000166170
database_cross_reference: RCD:Xa4kF
database_cross_reference: RXNORM:1311476
database_cross_reference: SNM:F-10100
database_cross_reference: SNMI:C-11300
database_cross_reference: SNOMEDCT_US:85378003

Chlorine
type: Class
subclass of: Halogens
subclass of: Gases
PMOID: PMO:00015304
Subclass_of: Gases
Subclass_of: Halogens
Synonym: CHLORINE
Synonym: Chlorine (substance)
Synonym: Chlorine [Chemical/Ingredient]
Synonym: Chlorine gas
Synonym: Chlorine, NOS
Synonym: Cl
Synonym: Cl - Chlorine
Synonym: Cl element
Synonym: chlorine
Synonym: chlorine gas
Tree Number: T6.1.6.4.3
Tree Number: T6.1.8.5
database_cross_reference: AOD:0000019490
database_cross_reference: AOD:0000028717
database_cross_reference: CHV:0000002824
database_cross_reference: CSP:1374-2714
database_cross_reference: CSP:4007-0028
database_cross_reference: DRUGBANK:DB11109
database_cross_reference: LCH:U000972
database_cross_reference: LCH_NW:sh85024541
database_cross_reference: LNC:LP18922-2
database_cross_reference: LNC:MTHU006887
database_cross_reference: MSH:D002713
database_cross_reference: MTH:U001805
database_cross_reference: MTHSPL:4R7X1O2820
database_cross_reference: NCI:C28140
database_cross_reference: NCI_NCI-GLOSS:CDR0000044424
database_cross_reference: NDFRT:N0000166171
database_cross_reference: NDFRT:N0000171756
database_cross_reference: RCD:X79Au
database_cross_reference: RXNORM:1310122
database_cross_reference: SNMI:C-11200
database_cross_reference: SNOMEDCT_US:29276003
database_cross_reference: VANDF:4025220

Fluorine
type: Class
subclass of: Halogens
PMOID: PMO:00015305
Subclass_of: Halogens
Synonym: F
Synonym: F - Fluorine
Synonym: F element
Synonym: FLUORINE
Synonym: Fluorine (substance)
Synonym: Fluorine [Chemical/Ingredient]
Synonym: Fluorine, NOS
Synonym: fluorine
Synonym: fluorines
Tree Number: T6.1.6.4.4
database_cross_reference: AOD:0000019489
database_cross_reference: CHV:0000005122
database_cross_reference: CSP:1374-2951
database_cross_reference: CSP:4007-0046
database_cross_reference: LCH:U001829
database_cross_reference: LCH_NW:sh85049424
database_cross_reference: MSH:D005461
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:284SYP0193
database_cross_reference: NCI:C502
database_cross_reference: NDFRT:N0000010504
database_cross_reference: NDFRT:N0000023134
database_cross_reference: RCD:Ub09Y
database_cross_reference: RXNORM:1310123
database_cross_reference: SNMI:C-11100
database_cross_reference: SNOMEDCT_US:35883004
database_cross_reference: VANDF:4017805

Iodine
type: Class
subclass of: Halogens
PMOID: PMO:00015306
Subclass_of: Halogens
Synonym: Alphadine Scrub Foam Antimicrobial Foam
Synonym: Alphadine Scrub Topical Microbiocidal Skin Cleanser
Synonym: Basic Foley Cath Kit Iodophor Pvp Pad 1%
Synonym: Blood Culture Prep Kit
Synonym: CVS Iodine
Synonym: Chela Potassium Plus
Synonym: Colloidal Iodine Ophthalmic
Synonym: Diodine
Synonym: Foam Care Pvp Iodophor Surg Hand Scrub 0.75%
Synonym: GNP Idoinde Tincture 2% Mild
Tree Number: T6.1.6.4.5
database_cross_reference: AOD:0000007536
database_cross_reference: ATC:D08AG03
database_cross_reference: CHV:0000006899
database_cross_reference: CSP:1374-3188
database_cross_reference: DRUGBANK:DB00898
database_cross_reference: DRUGBANK:DB05382
database_cross_reference: DRUGBANK:DB06715
database_cross_reference: DRUGBANK:DB06812
database_cross_reference: DRUGBANK:DB11119
database_cross_reference: LCH:U002497
database_cross_reference: LCH_NW:sh85067769
database_cross_reference: LNC:LP15157-8
database_cross_reference: LNC:MTHU009375
database_cross_reference: MEDCIN:198714
database_cross_reference: MEDCIN:199206
database_cross_reference: MMSL:4900
database_cross_reference: MMSL:d05776
database_cross_reference: MSH:D007455
database_cross_reference: MTH:U002017
database_cross_reference: MTHSPL:9679TC07X4
database_cross_reference: NCI:C594
database_cross_reference: NCI_DCP:04675
database_cross_reference: NCI_DTP:NSC0042355
database_cross_reference: NCI_FDA:9679TC07X4
database_cross_reference: NCI_NCI-GLOSS:CDR0000044548
database_cross_reference: NDDF:000852
database_cross_reference: NDDF:003150
database_cross_reference: NDDF:007599
database_cross_reference: NDFRT:N0000007196
database_cross_reference: NDFRT:N0000146037
database_cross_reference: RCD:XM0lG
database_cross_reference: RCD:fa2..
database_cross_reference: RXNORM:5933
database_cross_reference: SNM:F-10310
database_cross_reference: SNMI:C-11400
database_cross_reference: SNOMEDCT_US:325330005
database_cross_reference: SNOMEDCT_US:44588005
database_cross_reference: VANDF:4017659

Iodine Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015307
Subclass_of: Isotopes
Synonym: Iodine Isotopes [Chemical/Ingredient]
Synonym: Iodine isotope
Synonym: Iodine isotope (substance)
Synonym: Iodine--Isotopes
Synonym: Isotopes, Iodine
Tree Number: T6.1.9.10
database_cross_reference: LCH_NW:sh85067771
database_cross_reference: MSH:D007456
database_cross_reference: NDFRT:N0000166139
database_cross_reference: SNMI:C-11401
database_cross_reference: SNOMEDCT_US:67719005

Iodine Radioisotopes
type: Class
subclass of: Iodine Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015308
Subclass_of: Iodine Isotopes
Subclass_of: Radioisotopes
Synonym: Iodine Radioisotopes [Chemical/Ingredient]
Synonym: Iodine radioesotope, NOS
Synonym: Iodine radioisotope
Synonym: Iodine radioisotope (substance)
Synonym: Iodine radioisotope, NOS
Synonym: Radioisotopes, Iodine
Tree Number: T6.1.9.10.1
Tree Number: T6.1.9.17.16
database_cross_reference: MSH:D007457
database_cross_reference: NDFRT:N0000166140
database_cross_reference: SNM:E-510X
database_cross_reference: SNMI:C-114A0
database_cross_reference: SNOMEDCT_US:14399003

Hydrogen
type: Class
subclass of: Elements
subclass of: Gases
PMOID: PMO:00015309
Subclass_of: Elements
Subclass_of: Gases
Synonym: H - Hydrogen
Synonym: H element
Synonym: H2 - Hydrogen
Synonym: HYDROGEN
Synonym: Hydrogen (substance)
Synonym: Hydrogen [Chemical/Ingredient]
Synonym: Hydrogen, NOS
Synonym: hydrogen
Synonym: hydrogen (H)
Tree Number: T6.1.6.5
Tree Number: T6.1.8.7
database_cross_reference: AOD:0000001304
database_cross_reference: CHV:0000006354
database_cross_reference: CSP:1473-8637
database_cross_reference: CSP:4007-0059
database_cross_reference: LCH:U002277
database_cross_reference: LCH_NW:sh85063416
database_cross_reference: LNC:LP15643-7
database_cross_reference: MSH:D006859
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7YNJ3PO35Z
database_cross_reference: NDFRT:N0000166166
database_cross_reference: PSY:23650
database_cross_reference: RCD:X80At
database_cross_reference: RXNORM:5497
database_cross_reference: SNM:E-5011
database_cross_reference: SNMI:C-10100
database_cross_reference: SNOMEDCT_US:2141009

Deuterium
type: Class
subclass of: Hydrogen
subclass of: Isotopes
PMOID: PMO:00015310
Subclass_of: Hydrogen
Subclass_of: Isotopes
Synonym: 2 H
Synonym: 2H
Synonym: Deuterium (substance)
Synonym: Deuterium [Chemical/Ingredient]
Synonym: Deuterium gas
Synonym: H2 isotope
Synonym: Heavy hydrogen
Synonym: ^2^H
Synonym: deuterium
Synonym: h 2
Tree Number: T6.1.6.5.1
Tree Number: T6.1.8.7.1
Tree Number: T6.1.9.7
database_cross_reference: AOD:0000019449
database_cross_reference: CHV:0000003818
database_cross_reference: CSP:1647-6878
database_cross_reference: LCH:U001361
database_cross_reference: LCH_NW:sh85037316
database_cross_reference: MSH:D003903
database_cross_reference: MTH:NOCODE
database_cross_reference: NDFRT:N0000166156
database_cross_reference: SNM:E-5014
database_cross_reference: SNMI:C-10102
database_cross_reference: SNOMEDCT_US:91137000

Tritium
type: Class
subclass of: Hydrogen
subclass of: Radioisotopes
PMOID: PMO:00015311
Subclass_of: Hydrogen
Subclass_of: Radioisotopes
Synonym: 3 H
Synonym: 3 h
Synonym: 3H
Synonym: H3 radionuclide
Synonym: Hydrogen 3
Synonym: Hydrogen-3
Synonym: Tritium (substance)
Synonym: Tritium [Chemical/Ingredient]
Synonym: ^3^H
Synonym: h 3
Tree Number: T6.1.6.5.3
Tree Number: T6.1.8.7.3
Tree Number: T6.1.9.17.35
database_cross_reference: AOD:0000019450
database_cross_reference: CHV:0000012588
database_cross_reference: CSP:2543-6275
database_cross_reference: LCH:U004789
database_cross_reference: LCH_NW:sh85137936
database_cross_reference: LNC:LP29127-5
database_cross_reference: LNC:MTHU013330
database_cross_reference: MSH:D014316
database_cross_reference: NDFRT:N0000166155
database_cross_reference: SNM:E-5012
database_cross_reference: SNMI:C-10103
database_cross_reference: SNOMEDCT_US:16082008

Metals, Alkali
type: Class
subclass of: Elements
subclass of: Metals
PMOID: PMO:00015312
Subclass_of: Elements
Subclass_of: Metals
Synonym: Alkali Metals
Synonym: Alkali metals
Synonym: Elements, Group 1
Synonym: Group 1 Elements
Synonym: Metals, Alkali [Chemical/Ingredient]
Synonym: alkali metal
Synonym: alkali metals
Tree Number: T6.1.10.3
Tree Number: T6.1.6.6
database_cross_reference: AOD:0000019453
database_cross_reference: CSP:1852-5946
database_cross_reference: LCH_NW:sh85003587
database_cross_reference: MSH:D008672
database_cross_reference: NDFRT:N0000007991

Cesium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Heavy
PMOID: PMO:00015313
Subclass_of: Metals, Alkali
Subclass_of: Metals, Heavy
Synonym: CESIUM
Synonym: Caesium
Synonym: Cesium (substance)
Synonym: Cesium [Chemical/Ingredient]
Synonym: Cesium, NOS
Synonym: Cs element
Synonym: caesium
Synonym: cesium
Synonym: cesium (Cs)
Tree Number: T6.1.10.3.1
Tree Number: T6.1.10.6.9
Tree Number: T6.1.6.12.9
Tree Number: T6.1.6.6.1
database_cross_reference: AOD:0000019456
database_cross_reference: CHV:0000002704
database_cross_reference: CSP:1852-6049
database_cross_reference: LCH:U000918
database_cross_reference: LCH_NW:sh85022200
database_cross_reference: LNC:LP16811-9
database_cross_reference: LNC:MTHU014149
database_cross_reference: MSH:D002586
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:1KSV9V4Y4I
database_cross_reference: NDDF:014059
database_cross_reference: NDFRT:N0000166264
database_cross_reference: RXNORM:1310121
database_cross_reference: SNM:F-10220
database_cross_reference: SNMI:C-14200
database_cross_reference: SNOMEDCT_US:5040002

Cesium Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015314
Subclass_of: Isotopes
Synonym: Caesium isotope
Synonym: Cesium Isotopes [Chemical/Ingredient]
Synonym: Cesium isotope
Synonym: Cesium isotope (substance)
Synonym: Cesium isotope [dup] (substance)
Synonym: Cesium--Isotopes
Synonym: Isotopes, Cesium
Tree Number: T6.1.9.4
database_cross_reference: LCH_NW:sh85022201
database_cross_reference: MSH:D002587
database_cross_reference: NDFRT:N0000166121
database_cross_reference: SNMI:C-14201
database_cross_reference: SNOMEDCT_US:276174007
database_cross_reference: SNOMEDCT_US:53532001

Cesium Radioisotopes
type: Class
subclass of: Cesium Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015315
Subclass_of: Cesium Isotopes
Subclass_of: Radioisotopes
Synonym: Caesium radioisotope
Synonym: Cesium Radioisotopes [Chemical/Ingredient]
Synonym: Cesium radioisotope
Synonym: Cesium radioisotope (substance)
Synonym: Cesium radioisotope [dup] (substance)
Synonym: Cesium radioisotope, NOS
Synonym: Radioisotopes, Cesium
Tree Number: T6.1.9.17.7
Tree Number: T6.1.9.4.1
database_cross_reference: MSH:D002588
database_cross_reference: NDFRT:N0000166122
database_cross_reference: SNM:E-5220
database_cross_reference: SNMI:C-142A0
database_cross_reference: SNOMEDCT_US:276175008
database_cross_reference: SNOMEDCT_US:69703007

Lithium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Light
PMOID: PMO:00015316
Subclass_of: Metals, Alkali
Subclass_of: Metals, Light
Synonym: LITHIUM
Synonym: Li
Synonym: Li - Lithium
Synonym: Li element
Synonym: Li+ element
Synonym: Lithium (product)
Synonym: Lithium (substance)
Synonym: Lithium Metallicum
Synonym: Lithium [Chemical/Ingredient]
Synonym: Lithium product
Tree Number: T6.1.10.3.3
Tree Number: T6.1.10.7.3
Tree Number: T6.1.6.13.3
Tree Number: T6.1.6.6.3
database_cross_reference: AOD:0000019454
database_cross_reference: ATC:N05AN01
database_cross_reference: CHV:0000007490
database_cross_reference: CSP:1852-6098
database_cross_reference: DRUGBANK:DB01356
database_cross_reference: LCH:U002722
database_cross_reference: LCH_NW:sh85077577
database_cross_reference: LNC:LP16175-9
database_cross_reference: LNC:MTHU004197
database_cross_reference: MEDCIN:199593
database_cross_reference: MMSL:d00061
database_cross_reference: MSH:D008094
database_cross_reference: MTH:U002050
database_cross_reference: MTHSPL:9FN79X2M3F
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C1318
database_cross_reference: NCI:C95186
database_cross_reference: NCI_FDA:9FN79X2M3F
database_cross_reference: NCI_NCI-GLOSS:CDR0000476347
database_cross_reference: NDDF:001532
database_cross_reference: NDFRT:N0000147892
database_cross_reference: NDFRT:N0000166224
database_cross_reference: PDQ:CDR0000039491
database_cross_reference: PSY:28590
database_cross_reference: RCD:XM0lB
database_cross_reference: RCD:d6...
database_cross_reference: RXNORM:6448
database_cross_reference: SNM:F-10380
database_cross_reference: SNMI:C-15400
database_cross_reference: SNOMEDCT_US:321719003
database_cross_reference: SNOMEDCT_US:85899009
database_cross_reference: USPMG:MTHU000811
database_cross_reference: VANDF:4019803

Potassium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Light
PMOID: PMO:00015317
Subclass_of: Metals, Alkali
Subclass_of: Metals, Light
Synonym: Alphaligo
Synonym: Aminosyn 3.5% M
Synonym: Aqua-S Supplement
Synonym: B 6 Plus
Synonym: Bseltzer
Synonym: Buffered Vitamin C Powder With Ca Mg and K
Synonym: Buffered Vitamin C Pwr W Cal-mag-potassium
Synonym: C-1000 Plus Zinc & Potassium
Synonym: C.R.D.-force
Synonym: Cal & Mag Hvp Chel Plus C Potass & Zinc Tab
Tree Number: T6.1.10.3.4
Tree Number: T6.1.10.7.5
Tree Number: T6.1.6.13.5
Tree Number: T6.1.6.6.4
database_cross_reference: AOD:0000002435
database_cross_reference: CCPSS:1006930
database_cross_reference: CCPSS:1013246
database_cross_reference: CHV:0000010004
database_cross_reference: CSP:2390-5099
database_cross_reference: CSP:4007-0102
database_cross_reference: DRUGBANK:DB01345
database_cross_reference: LCH:U003782
database_cross_reference: LCH_NW:sh85105593
database_cross_reference: LNC:LP15098-4
database_cross_reference: LNC:LP32134-6
database_cross_reference: LNC:MTHU003561
database_cross_reference: MEDCIN:41250
database_cross_reference: MMSL:5321
database_cross_reference: MSH:D011188
database_cross_reference: MTH:U000145
database_cross_reference: MTH:U000315
database_cross_reference: MTH:U002180
database_cross_reference: MTHSPL:RWP5GA015D
database_cross_reference: NCI:C765
database_cross_reference: NCI_DCP:31091
database_cross_reference: NCI_NCI-GLOSS:CDR0000044344
database_cross_reference: NDDF:000763
database_cross_reference: NDFRT:N0000005839
database_cross_reference: NDFRT:N0000146069
database_cross_reference: PSY:39750
database_cross_reference: RCD:X80D4
database_cross_reference: RCD:x01Pg
database_cross_reference: RXNORM:8588
database_cross_reference: SNM:F-10530
database_cross_reference: SNMI:C-13500
database_cross_reference: SNOMEDCT_US:350560002
database_cross_reference: SNOMEDCT_US:88480006
database_cross_reference: USPMG:MTHU001685
database_cross_reference: VANDF:4017695

Potassium Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015318
Subclass_of: Isotopes
Synonym: Isotopes, Potassium
Synonym: Potassium Isotopes [Chemical/Ingredient]
Synonym: Potassium isotope
Synonym: Potassium isotope (substance)
Synonym: Potassium--Isotopes
Tree Number: T6.1.9.16
database_cross_reference: LCH_NW:sh85105594
database_cross_reference: MSH:D011194
database_cross_reference: NDFRT:N0000166147
database_cross_reference: SNMI:C-13501
database_cross_reference: SNOMEDCT_US:14146003

Potassium Radioisotopes
type: Class
subclass of: Potassium Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015319
Subclass_of: Potassium Isotopes
Subclass_of: Radioisotopes
Synonym: Potassium Radioisotopes [Chemical/Ingredient]
Synonym: Potassium radioisotope
Synonym: Potassium radioisotope (substance)
Synonym: Potassium radioisotope, NOS
Synonym: Radioisotopes, Potassium
Tree Number: T6.1.9.16.1
Tree Number: T6.1.9.17.25
database_cross_reference: MSH:D011197
database_cross_reference: NDFRT:N0000166148
database_cross_reference: SNM:E-5193
database_cross_reference: SNMI:C-135A0
database_cross_reference: SNOMEDCT_US:56167000

Rubidium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Heavy
PMOID: PMO:00015320
Subclass_of: Metals, Alkali
Subclass_of: Metals, Heavy
Synonym: RUBIDIUM
Synonym: Rb
Synonym: Rb element
Synonym: Rubidium (substance)
Synonym: Rubidium Metallicum
Synonym: Rubidium [Chemical/Ingredient]
Synonym: Rubidium, NOS
Synonym: rubidium
Synonym: rubidium (Rb)
Tree Number: T6.1.10.3.5
Tree Number: T6.1.10.6.42
Tree Number: T6.1.6.12.42
Tree Number: T6.1.6.6.5
database_cross_reference: AOD:0000019455
database_cross_reference: CHV:0000010963
database_cross_reference: CSP:1852-6152
database_cross_reference: LCH:U004171
database_cross_reference: LCH_NW:sh85115684
database_cross_reference: LNC:LP16833-3
database_cross_reference: LNC:MTHU014145
database_cross_reference: MSH:D012413
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:MLT4718TJW
database_cross_reference: NCI:C95191
database_cross_reference: NCI_FDA:MLT4718TJW
database_cross_reference: NDFRT:N0000005885
database_cross_reference: RXNORM:1311489
database_cross_reference: SNM:F-10540
database_cross_reference: SNMI:C-15900
database_cross_reference: SNOMEDCT_US:51304003

Sodium
type: Class
subclass of: Metals, Alkali
subclass of: Metals, Light
PMOID: PMO:00015321
Subclass_of: Metals, Alkali
Subclass_of: Metals, Light
Synonym: Na
Synonym: Na - Sodium
Synonym: Na element
Synonym: SODIUM
Synonym: Sodium (NOS)
Synonym: Sodium (substance)
Synonym: Sodium [Chemical/Ingredient]
Synonym: Sodium, NOS
Synonym: na sodium
Synonym: sodium
Tree Number: T6.1.10.3.6
Tree Number: T6.1.10.7.6
Tree Number: T6.1.6.13.6
Tree Number: T6.1.6.6.6
database_cross_reference: AOD:0000005817
database_cross_reference: AOD:0000028710
database_cross_reference: CCPSS:0024754
database_cross_reference: CHV:0000011478
database_cross_reference: CSP:2730-2702
database_cross_reference: CSP:4007-0114
database_cross_reference: LCH:U004374
database_cross_reference: LCH_NW:sh85124249
database_cross_reference: LNC:LP15099-2
database_cross_reference: LNC:LP32156-9
database_cross_reference: LNC:MTHU003686
database_cross_reference: MEDLINEPLUS:3666
database_cross_reference: MMSL:5467
database_cross_reference: MSH:D012964
database_cross_reference: MTH:U003358
database_cross_reference: MTHSPL:9NEZ333N27
database_cross_reference: MTHSPL:NOCODE
database_cross_reference: NCI:C830
database_cross_reference: NCI_DCP:31090
database_cross_reference: NCI_NCI-GLOSS:CDR0000044731
database_cross_reference: NDDF:000755
database_cross_reference: NDFRT:N0000007201
database_cross_reference: NDFRT:N0000146496
database_cross_reference: PSY:48590
database_cross_reference: RCD:X80D5
database_cross_reference: RXNORM:9853
database_cross_reference: SNM:F-10580
database_cross_reference: SNMI:C-15500
database_cross_reference: SNOMEDCT_US:39972003
database_cross_reference: USPMG:MTHU001768
database_cross_reference: VANDF:4018159

Sodium Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015322
Subclass_of: Isotopes
Synonym: Isotopes, Sodium
Synonym: Sodium Isotopes [Chemical/Ingredient]
Synonym: Sodium isotope
Synonym: Sodium isotope (substance)
Tree Number: T6.1.9.18
database_cross_reference: MSH:D012975
database_cross_reference: NDFRT:N0000166131
database_cross_reference: SNMI:C-15501
database_cross_reference: SNOMEDCT_US:31936008

Sodium Radioisotopes
type: Class
subclass of: Sodium Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015323
Subclass_of: Radioisotopes
Subclass_of: Sodium Isotopes
Synonym: Radioisotopes, Sodium
Synonym: Sodium Radioisotopes [Chemical/Ingredient]
Synonym: Sodium radioisotope
Synonym: Sodium radioisotope (substance)
Synonym: Sodium radioisotope, NOS
Tree Number: T6.1.9.17.30
Tree Number: T6.1.9.18.1
database_cross_reference: MSH:D012979
database_cross_reference: NDFRT:N0000166132
database_cross_reference: SNM:E-5244
database_cross_reference: SNMI:C-155A0
database_cross_reference: SNOMEDCT_US:76527008

Metals, Alkaline Earth
type: Class
subclass of: Elements
subclass of: Metals
PMOID: PMO:00015324
Subclass_of: Elements
Subclass_of: Metals
Synonym: Alkaline Earth Metals
Synonym: Alkaline earth metals
Synonym: Earth Metals, Alkaline
Synonym: Elements, Group 2
Synonym: Group 2 Elements
Synonym: Metals, Alkaline Earth [Chemical/Ingredient]
Synonym: alkaline earth metal
Synonym: alkaline earth metals
Tree Number: T6.1.10.4
Tree Number: T6.1.6.7
database_cross_reference: AOD:0000019458
database_cross_reference: CSP:1852-6255
database_cross_reference: LCH:U000145
database_cross_reference: LCH_NW:sh85003595
database_cross_reference: MSH:D008673
database_cross_reference: NDFRT:N0000007992

Barium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: Metals, Heavy
PMOID: PMO:00015325
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Heavy
Synonym: BARIUM
Synonym: Ba
Synonym: Ba - Barium
Synonym: Ba element
Synonym: Barium (product)
Synonym: Barium (substance)
Synonym: Barium [Chemical/Ingredient]
Synonym: Barium, NOS
Synonym: ba
Synonym: barium
Tree Number: T6.1.10.4.1
Tree Number: T6.1.10.6.4
Tree Number: T6.1.6.12.4
Tree Number: T6.1.6.7.1
database_cross_reference: AOD:0000019461
database_cross_reference: CHV:0000001701
database_cross_reference: CSP:1852-6358
database_cross_reference: DRUGBANK:DB12481
database_cross_reference: LCH:U000499
database_cross_reference: LCH_NW:sh85011853
database_cross_reference: LNC:LP16803-6
database_cross_reference: LNC:MTHU006093
database_cross_reference: MSH:D001464
database_cross_reference: MTH:U001727
database_cross_reference: MTHSPL:24GP945V5T
database_cross_reference: NCI:C61475
database_cross_reference: NCI_FDA:24GP945V5T
database_cross_reference: NDFRT:N0000166273
database_cross_reference: PSY:05420
database_cross_reference: RCD:X808b
database_cross_reference: RXNORM:1311067
database_cross_reference: SNM:F-10080
database_cross_reference: SNMI:C-12200
database_cross_reference: SNOMEDCT_US:39290007
database_cross_reference: SNOMEDCT_US:426728000
database_cross_reference: UMD:-1929

Beryllium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: Metals, Light
PMOID: PMO:00015326
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Light
Synonym: BERYLLIUM
Synonym: Be
Synonym: Be - Beryllium
Synonym: Be element
Synonym: Beryllium (substance)
Synonym: Beryllium Metal
Synonym: Beryllium Powder
Synonym: Beryllium [Chemical/Ingredient]
Synonym: Beryllium, NOS
Synonym: beryllium
Tree Number: T6.1.10.7.2
Tree Number: T6.1.6.13.2
Tree Number: T6.1.6.7.2
database_cross_reference: AOD:0000019459
database_cross_reference: CHV:0000001816
database_cross_reference: CSP:1852-6461
database_cross_reference: LCH:U000545
database_cross_reference: LCH_NW:sh85013403
database_cross_reference: LNC:LP16805-1
database_cross_reference: LNC:MTHU005565
database_cross_reference: MSH:D001608
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:OW5102UV6N
database_cross_reference: NCI:C44338
database_cross_reference: NCI_FDA:OW5102UV6N
database_cross_reference: NDFRT:N0000166277
database_cross_reference: RCD:X794s
database_cross_reference: RXNORM:1310252
database_cross_reference: SNMI:C-12300
database_cross_reference: SNOMEDCT_US:88014003

Calcium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: PMO:00021947
PMOID: PMO:00015327
Subclass_of: Blood Coagulation Factors
Subclass_of: Metals, Alkaline Earth
Synonym: 7030 Calcium Gold
Synonym: 7030 Calcium Premium
Synonym: A D Calcium Tab
Synonym: A-D Calcium Cap
Synonym: A.R.T.H. Away Formula
Synonym: Act Etidrocal
Synonym: Acti-cal/mag 2:1 + Zinc and D Caplet
Synonym: Acti-megascorb Crystals Pwr
Synonym: Actical Plus Calcium-magnesium-vitamin D3-silicon Chewable
Synonym: Active Calcium Plus Magnesium, Vitamin D and Silicon
Tree Number: T6.1.10.4.2
Tree Number: T6.1.6.7.3
Tree Number: T6.13.4.2
database_cross_reference: AOD:0000001937
database_cross_reference: AOD:0000028712
database_cross_reference: CHV:0000002292
database_cross_reference: CSP:0530-2463
database_cross_reference: CSP:4007-0018
database_cross_reference: DRUGBANK:DB01373
database_cross_reference: LCH:U000740
database_cross_reference: LCH_NW:sh85018768
database_cross_reference: LNC:LP15257-6
database_cross_reference: LNC:LP32547-9
database_cross_reference: LNC:LP70404-6
database_cross_reference: LNC:MTHU001930
database_cross_reference: MEDCIN:41226
database_cross_reference: MMSL:4325
database_cross_reference: MMSL:6778
database_cross_reference: MSH:D002118
database_cross_reference: MTH:U000229
database_cross_reference: MTH:U001774
database_cross_reference: MTHSPL:SY7Q814VUP
database_cross_reference: NCI:C331
database_cross_reference: NCI_DCP:30724
database_cross_reference: NCI_FDA:SY7Q814VUP
database_cross_reference: NCI_NCI-GLOSS:CDR0000045632
database_cross_reference: NDDF:000771
database_cross_reference: NDFRT:N0000006512
database_cross_reference: NDFRT:N0000146031
database_cross_reference: PSY:07240
database_cross_reference: RCD:X80Cy
database_cross_reference: RCD:Xa4k9
database_cross_reference: RXNORM:1895
database_cross_reference: SNM:F-10120
database_cross_reference: SNM:F-53040
database_cross_reference: SNMI:C-14300
database_cross_reference: SNMI:F-D7340
database_cross_reference: SNOMEDCT_US:290128009
database_cross_reference: SNOMEDCT_US:5540006
database_cross_reference: SNOMEDCT_US:80161001
database_cross_reference: VANDF:4017652

Calcium Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015328
Subclass_of: Isotopes
Synonym: Calcium Isotopes [Chemical/Ingredient]
Synonym: Calcium isotope
Synonym: Calcium isotope (substance)
Synonym: Calcium--Isotopes
Synonym: Isotopes, Calcium
Tree Number: T6.1.9.1
database_cross_reference: LCH_NW:sh85018770
database_cross_reference: MSH:D002127
database_cross_reference: NDFRT:N0000166115
database_cross_reference: SNMI:C-14301
database_cross_reference: SNOMEDCT_US:64974009

Calcium Radioisotopes
type: Class
subclass of: Calcium Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015329
Subclass_of: Calcium Isotopes
Subclass_of: Radioisotopes
Synonym: Calcium Radioisotopes [Chemical/Ingredient]
Synonym: Calcium radioisotope
Synonym: Calcium radioisotope (substance)
Synonym: Calcium radioisotope, NOS
Synonym: Radioisotopes, Calcium
Tree Number: T6.1.9.1.1
Tree Number: T6.1.9.17.4
database_cross_reference: MSH:D002132
database_cross_reference: NDFRT:N0000166116
database_cross_reference: SNM:E-5222
database_cross_reference: SNMI:C-143A0
database_cross_reference: SNOMEDCT_US:33137005

Magnesium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: Metals, Light
PMOID: PMO:00015330
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Light
Synonym: Acetabolan III Vitamin and Mineral Supplement
Synonym: Acetabolan-II Vitamin and Mineral Supplement
Synonym: Acti Mag 250 Caplet
Synonym: Acti-cal/mag 2:1 + Zinc and D Caplet
Synonym: Actical Plus Calcium-magnesium-vitamin D3-silicon Chewable
Synonym: Active Calcium Plus Magnesium, Vitamin D and Silicon
Synonym: Actyform
Synonym: Alphaligo
Synonym: Aminosyn 3.5% M
Synonym: Armax
Tree Number: T6.1.10.7.4
Tree Number: T6.1.6.13.4
Tree Number: T6.1.6.7.4
database_cross_reference: AOD:0000005765
database_cross_reference: AOD:0000028711
database_cross_reference: CCPSS:0046813
database_cross_reference: CHV:0000007660
database_cross_reference: CSP:1852-6512
database_cross_reference: CSP:4007-0080
database_cross_reference: DRUGBANK:DB01378
database_cross_reference: LCH:U002778
database_cross_reference: LCH_NW:sh85079651
database_cross_reference: LNC:LP14343-5
database_cross_reference: LNC:MTHU002163
database_cross_reference: MEDCIN:199598
database_cross_reference: MEDLINEPLUS:4298
database_cross_reference: MMSL:5005
database_cross_reference: MMSL:5535
database_cross_reference: MSH:D008274
database_cross_reference: MTH:U002057
database_cross_reference: MTHSPL:I38ZP9992A
database_cross_reference: NCI:C29239
database_cross_reference: NCI_DCP:03072
database_cross_reference: NCI_NCI-GLOSS:CDR0000373087
database_cross_reference: NDDF:000784
database_cross_reference: NDDF:004557
database_cross_reference: NDDF:004558
database_cross_reference: NDDF:004559
database_cross_reference: NDDF:004560
database_cross_reference: NDFRT:N0000006335
database_cross_reference: NDFRT:N0000146038
database_cross_reference: PSY:29110
database_cross_reference: RCD:X80D2
database_cross_reference: RXNORM:6574
database_cross_reference: SNM:F-10400
database_cross_reference: SNMI:C-14800
database_cross_reference: SNOMEDCT_US:72717003
database_cross_reference: USPMG:MTHU001746
database_cross_reference: VANDF:4017660

Strontium
type: Class
subclass of: Metals, Alkaline Earth
subclass of: Metals, Heavy
PMOID: PMO:00015331
Subclass_of: Metals, Alkaline Earth
Subclass_of: Metals, Heavy
Synonym: STRONTIUM
Synonym: Sr
Synonym: Sr - Strontium
Synonym: Strontium (substance)
Synonym: Strontium [Chemical/Ingredient]
Synonym: Strontium preparation
Synonym: Strontium preparation (product)
Synonym: Strontium, NOS
Synonym: strontium
Tree Number: T6.1.10.4.4
Tree Number: T6.1.10.6.45
Tree Number: T6.1.6.12.45
Tree Number: T6.1.6.7.6
database_cross_reference: AOD:0000019460
database_cross_reference: CHV:0000011785
database_cross_reference: CSP:1852-6564
database_cross_reference: LCH:U004499
database_cross_reference: LCH_NW:sh85129178
database_cross_reference: LNC:LP16835-8
database_cross_reference: LNC:MTHU003499
database_cross_reference: MSH:D013324
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:YZS2RPE8LE
database_cross_reference: NCI:C846
database_cross_reference: NCI_FDA:YZS2RPE8LE
database_cross_reference: NCI_NCI-GLOSS:CDR0000045913
database_cross_reference: NDDF:010549
database_cross_reference: NDFRT:N0000007902
database_cross_reference: RCD:X808l
database_cross_reference: RXNORM:10122
database_cross_reference: SNM:F-10590
database_cross_reference: SNMI:C-15800
database_cross_reference: SNOMEDCT_US:415633000
database_cross_reference: SNOMEDCT_US:43136004

Strontium Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015332
Subclass_of: Isotopes
Synonym: Isotopes, Strontium
Synonym: Strontium Isotopes [Chemical/Ingredient]
Synonym: Strontium isotope
Synonym: Strontium isotope (substance)
Synonym: Strontium--Isotopes
Tree Number: T6.1.9.19
database_cross_reference: LCH_NW:sh85129179
database_cross_reference: MSH:D013325
database_cross_reference: NDFRT:N0000166127
database_cross_reference: SNMI:C-15801
database_cross_reference: SNOMEDCT_US:44234001

Strontium Radioisotopes
type: Class
subclass of: Strontium Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015333
Subclass_of: Radioisotopes
Subclass_of: Strontium Isotopes
Synonym: Radioisotopes, Strontium
Synonym: Strontium Radioisotopes [Chemical/Ingredient]
Synonym: Strontium radioisotope
Synonym: Strontium radioisotope (substance)
Synonym: Strontium radioisotope, NOS
Tree Number: T6.1.9.17.31
Tree Number: T6.1.9.19.1
database_cross_reference: MSH:D013326
database_cross_reference: NDFRT:N0000166128
database_cross_reference: SNM:E-5271
database_cross_reference: SNMI:C-158A0
database_cross_reference: SNOMEDCT_US:54179002

Metals, Rare Earth
type: Class
subclass of: Elements
subclass of: Metals
PMOID: PMO:00015334
Subclass_of: Elements
Subclass_of: Metals
Synonym: Earth Metals, Rare
Synonym: Earths, Rare
Synonym: Metals, Rare Earth [Chemical/Ingredient]
Synonym: Rare Earth Metals
Synonym: Rare earth metal compounds
Synonym: Rare earth metals
Synonym: rare earth
Synonym: rare earth element
Synonym: rare earth elements
Synonym: rare earths
Tree Number: T6.1.10.5
Tree Number: T6.1.6.8
database_cross_reference: AOD:0000019526
database_cross_reference: CHV:0000008006
database_cross_reference: CSP:1853-0057
database_cross_reference: LCH:U004048
database_cross_reference: LCH:U005771
database_cross_reference: LCH:U005772
database_cross_reference: LCH_NW:sh85111458
database_cross_reference: MSH:D008674
database_cross_reference: NDFRT:N0000007993

Scandium
type: Class
subclass of: Metals, Rare Earth
subclass of: Transition Elements
PMOID: PMO:00015335
Subclass_of: Metals, Rare Earth
Subclass_of: Transition Elements
Synonym: SCANDIUM
Synonym: Scandium [Chemical/Ingredient]
Synonym: scandium
Tree Number: T6.1.10.5.1
Tree Number: T6.1.6.14.22
Tree Number: T6.1.6.8.1
database_cross_reference: AOD:0000019527
database_cross_reference: LCH:U004221
database_cross_reference: LCH_NW:sh85117977
database_cross_reference: LNC:LP28503-8
database_cross_reference: LNC:MTHU014130
database_cross_reference: MSH:D012538
database_cross_reference: MTHSPL:YUJ4U1EW7R
database_cross_reference: NDFRT:N0000166225
database_cross_reference: RXNORM:1311273

Yttrium
type: Class
subclass of: Metals, Rare Earth
subclass of: Transition Elements
PMOID: PMO:00015336
Subclass_of: Metals, Rare Earth
Subclass_of: Transition Elements
Synonym: Y
Synonym: YTTRIUM
Synonym: Yttrium (substance)
Synonym: Yttrium [Chemical/Ingredient]
Synonym: Yttrium, NOS
Synonym: yttrium
Tree Number: T6.1.10.5.2
Tree Number: T6.1.6.14.29
Tree Number: T6.1.6.8.2
database_cross_reference: AOD:0000019528
database_cross_reference: CHV:0000013265
database_cross_reference: CSP:2551-4006
database_cross_reference: LCH:U005080
database_cross_reference: LCH_NW:sh85149410
database_cross_reference: MSH:D015019
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:58784XQC3Y
database_cross_reference: NCI:C28199
database_cross_reference: NCI_NCI-GLOSS:CDR0000044261
database_cross_reference: NDFRT:N0000166239
database_cross_reference: RXNORM:1534770
database_cross_reference: SNMI:C-16200
database_cross_reference: SNOMEDCT_US:63754004

Yttrium Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015337
Subclass_of: Isotopes
Synonym: Isotopes, Yttrium
Synonym: Yttrium Isotopes [Chemical/Ingredient]
Synonym: Yttrium isotope
Synonym: Yttrium isotope (substance)
Synonym: Yttrium--Isotopes
Tree Number: T6.1.9.22
database_cross_reference: LCH_NW:sh85149411
database_cross_reference: MSH:D015020
database_cross_reference: NDFRT:N0000166111
database_cross_reference: SNMI:C-16201
database_cross_reference: SNOMEDCT_US:50491009

Yttrium Radioisotopes
type: Class
subclass of: Yttrium Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015338
Subclass_of: Radioisotopes
Subclass_of: Yttrium Isotopes
Synonym: Radioisotopes, Yttrium
Synonym: Yttrium Radioisotopes [Chemical/Ingredient]
Synonym: Yttrium radioisotope
Synonym: Yttrium radioisotope (substance)
Synonym: Yttrium radioisotope, NOS
Tree Number: T6.1.9.17.37
Tree Number: T6.1.9.22.1
database_cross_reference: MSH:D015021
database_cross_reference: NDFRT:N0000166112
database_cross_reference: SNMI:C-162A0
database_cross_reference: SNOMEDCT_US:68117004

Lanthanoid Series Elements
type: Class
subclass of: Metals, Rare Earth
PMOID: PMO:00015339
Subclass_of: Metals, Rare Earth
Synonym: Elements, Lanthanoid Series
Synonym: Lanthanides
Synonym: Lanthanoid Series Elements [Chemical/Ingredient]
Synonym: Lanthanoids
Synonym: lanthanide
Tree Number: T6.1.10.5.3
Tree Number: T6.1.6.8.3
database_cross_reference: CSP:1853-0057
database_cross_reference: MSH:D028581
database_cross_reference: NDFRT:N0000011410

Cerium Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015341
Subclass_of: Isotopes
Synonym: Cerium Isotopes [Chemical/Ingredient]
Synonym: Cerium--Isotopes
Synonym: Isotopes, Cerium
Tree Number: T6.1.9.3
database_cross_reference: LCH_NW:sh85022139
database_cross_reference: MSH:D002564
database_cross_reference: NDFRT:N0000166109

Cerium Radioisotopes
type: Class
subclass of: Cerium Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015342
Subclass_of: Cerium Isotopes
Subclass_of: Radioisotopes
Synonym: Cerium Radioisotopes [Chemical/Ingredient]
Synonym: Radioisotopes, Cerium
Tree Number: T6.1.9.17.6
Tree Number: T6.1.9.3.1
database_cross_reference: MSH:D002565
database_cross_reference: NDFRT:N0000166110

Lutetium
type: Class
subclass of: Transition Elements
PMOID: PMO:00015349
Subclass_of: Transition Elements
Synonym: LUTETIUM
Synonym: Lutetium (substance)
Synonym: Lutetium [Chemical/Ingredient]
Synonym: lutetium
Tree Number: T6.1.6.14.10
database_cross_reference: AOD:0000019543
database_cross_reference: CHV:0000007583
database_cross_reference: LCH:U002751
database_cross_reference: LCH_NW:sh85078994
database_cross_reference: MSH:D008187
database_cross_reference: MTHSPL:5H0DOZ21UJ
database_cross_reference: NDFRT:N0000166227
database_cross_reference: RXNORM:1534772
database_cross_reference: SNOMEDCT_US:447191008

Nitrogen
type: Class
subclass of: Elements
subclass of: Gases
PMOID: PMO:00015356
Subclass_of: Elements
Subclass_of: Gases
Synonym: Air USP
Synonym: Carbon Dioxide Mixture
Synonym: Carbon Monox, Helium, Oxygen, Nitrogen L.D.M.
Synonym: Co-HE-O2-N2 Mixture
Synonym: Co-NE-O2-N2 Mixture
Synonym: Compressed Gas N.O.S.
Synonym: Gaseous Nitrogen 99.0%
Synonym: Helium Oxygen Nitrogen mixture
Synonym: Hyperbaric Chamber Mix
Synonym: Liquid Nitrogen Nf
Tree Number: T6.1.6.9
Tree Number: T6.1.8.9
database_cross_reference: AOD:0000001947
database_cross_reference: ATC:V03AN04
database_cross_reference: CHV:0000008740
database_cross_reference: CSP:2076-7824
database_cross_reference: DRUGBANK:DB09152
database_cross_reference: LCH:U003246
database_cross_reference: LCH_NW:sh85092062
database_cross_reference: LNC:LP15746-8
database_cross_reference: LNC:MTHU006085
database_cross_reference: MSH:D009584
database_cross_reference: MTH:U002109
database_cross_reference: MTHSPL:N762921K75
database_cross_reference: NCI:C61863
database_cross_reference: NCI_FDA:N762921K75
database_cross_reference: NDDF:002515
database_cross_reference: NDFRT:N0000006654
database_cross_reference: NDFRT:N0000147408
database_cross_reference: PSY:34070
database_cross_reference: RCD:X799L
database_cross_reference: RXNORM:7456
database_cross_reference: SNM:F-10440
database_cross_reference: SNMI:C-10700
database_cross_reference: SNOMEDCT_US:36012007
database_cross_reference: VANDF:4019163

Nitrogen Isotopes
type: Class
subclass of: Nitrogen
subclass of: Isotopes
PMOID: PMO:00015357
Subclass_of: Isotopes
Subclass_of: Nitrogen
Synonym: Isotopes, Nitrogen
Synonym: Nitrogen Isotopes [Chemical/Ingredient]
Synonym: Nitrogen isotope
Synonym: Nitrogen isotope (substance)
Synonym: Nitrogen--Isotopes
Tree Number: T6.1.6.9.1
Tree Number: T6.1.8.9.1
Tree Number: T6.1.9.13
database_cross_reference: LCH_NW:sh85092064
database_cross_reference: MSH:D009587
database_cross_reference: NDFRT:N0000166145
database_cross_reference: SNMI:C-10701
database_cross_reference: SNOMEDCT_US:86575005

Nitrogen Radioisotopes
type: Class
subclass of: Nitrogen Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015358
Subclass_of: Nitrogen Isotopes
Subclass_of: Radioisotopes
Synonym: Nitrogen Radioisotopes [Chemical/Ingredient]
Synonym: Nitrogen radioisotope
Synonym: Nitrogen radioisotope (substance)
Synonym: Nitrogen radioisotope, NOS
Synonym: Radioisotopes, Nitrogen
Tree Number: T6.1.9.13.1
Tree Number: T6.1.9.17.22
database_cross_reference: MSH:D009590
database_cross_reference: NDFRT:N0000166146
database_cross_reference: SNM:E-5071
database_cross_reference: SNMI:C-107A0
database_cross_reference: SNOMEDCT_US:86710005

Phosphorus
type: Class
subclass of: Elements
PMOID: PMO:00015359
Subclass_of: Elements
Synonym: P
Synonym: P element
Synonym: PHOSPHORUS
Synonym: Phosphoric
Synonym: Phosphorous
Synonym: Phosphorous (NOS)
Synonym: Phosphorus (substance)
Synonym: Phosphorus [Chemical/Ingredient]
Synonym: Phosphorus, NOS
Synonym: mineral supplements phosphorus preparations
Tree Number: T6.1.6.10
database_cross_reference: AOD:0000001941
database_cross_reference: CHV:0000009676
database_cross_reference: CSP:2301-3551
database_cross_reference: LCH:U003643
database_cross_reference: LCH_NW:sh85101119
database_cross_reference: LNC:MTHU014112
database_cross_reference: MEDCIN:41245
database_cross_reference: MEDLINEPLUS:4298
database_cross_reference: MMSL:5295
database_cross_reference: MSH:D010758
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:27YLU75U4W
database_cross_reference: NCI:C28375
database_cross_reference: NCI:C47934
database_cross_reference: NCI_DCP:31089
database_cross_reference: NCI_NCI-GLOSS:CDR0000044340
database_cross_reference: NCI_NCI-GLOSS:CDR0000044356
database_cross_reference: NDDF:000863
database_cross_reference: NDFRT:N0000006920
database_cross_reference: NDFRT:N0000146063
database_cross_reference: PSY:38370
database_cross_reference: RCD:X796m
database_cross_reference: RXNORM:8263
database_cross_reference: SNM:F-10510
database_cross_reference: SNMI:C-10600
database_cross_reference: SNOMEDCT_US:30820000
database_cross_reference: VANDF:4017689

Phosphorus Isotopes
type: Class
subclass of: Phosphorus
subclass of: Isotopes
PMOID: PMO:00015360
Subclass_of: Isotopes
Subclass_of: Phosphorus
Synonym: Isotopes, Phosphorus
Synonym: Phosphorus Isotopes [Chemical/Ingredient]
Synonym: Phosphorus isotope
Synonym: Phosphorus isotope (substance)
Synonym: Phosphorus--Isotopes
Tree Number: T6.1.6.10.1
Tree Number: T6.1.9.15
database_cross_reference: LCH_NW:sh85101120
database_cross_reference: MSH:D010759
database_cross_reference: NDFRT:N0000166125
database_cross_reference: SNMI:C-10601
database_cross_reference: SNOMEDCT_US:7156005

Phosphorus Radioisotopes
type: Class
subclass of: Phosphorus Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015361
Subclass_of: Phosphorus Isotopes
Subclass_of: Radioisotopes
Synonym: Phosphorus Radioisotopes [Chemical/Ingredient]
Synonym: Phosphorus radioisotope
Synonym: Phosphorus radioisotope (substance)
Synonym: Phosphorus radioisotope, NOS
Synonym: Radioisotopes, Phosphorus
Tree Number: T6.1.9.15.1
Tree Number: T6.1.9.17.24
database_cross_reference: MSH:D010761
database_cross_reference: NDFRT:N0000166126
database_cross_reference: SNM:E-5097
database_cross_reference: SNMI:C-106A0
database_cross_reference: SNOMEDCT_US:77923008

Chalcogens
type: Class
subclass of: Elements
PMOID: PMO:00015362
Subclass_of: Elements
Synonym: Chalcogens [Chemical/Ingredient]
Synonym: Elements, Group 16
Synonym: Group 16 Elements
Tree Number: T6.1.6.11
database_cross_reference: LCH_NW:sh2002008811
database_cross_reference: MSH:D018011
database_cross_reference: NDFRT:N0000007935

Oxygen
type: Class
subclass of: Chalcogens
subclass of: Gases
PMOID: PMO:00015363
Subclass_of: Chalcogens
Subclass_of: Gases
Synonym: Air Compressed Medical Air
Synonym: Air USP
Synonym: Alnox Gas
Synonym: Carbon Dioxide 1% W Oxygen
Synonym: Carbon Dioxide 12.1% W Oxygen
Synonym: Carbon Dioxide 23.1% W Oxygen
Synonym: Carbon Dioxide 7.1% W Oxygen
Synonym: Carbon Dioxide Mixture
Synonym: Carbon Dioxide Oxygen Mix
Synonym: Carbon Dioxide Oxygen Mixture 5/95
Tree Number: T6.1.6.11.1
Tree Number: T6.1.8.11
database_cross_reference: AOD:0000001289
database_cross_reference: ATC:V03AN01
database_cross_reference: CHV:0000009153
database_cross_reference: CSP:2189-1281
database_cross_reference: DRUGBANK:DB09140
database_cross_reference: LCH:U003425
database_cross_reference: LCH_NW:sh85096329
database_cross_reference: LNC:LP14536-4
database_cross_reference: LNC:LP99292-2
database_cross_reference: LNC:MTHU002757
database_cross_reference: MMSL:d06860
database_cross_reference: MSH:D010100
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000131
database_cross_reference: MTH:U000187
database_cross_reference: MTHSPL:S88TT14065
database_cross_reference: NCI:C722
database_cross_reference: NCI_FDA:S88TT14065
database_cross_reference: NCI_NCI-GLOSS:CDR0000538149
database_cross_reference: NDDF:000826
database_cross_reference: NDFRT:N0000006405
database_cross_reference: NDFRT:N0000147362
database_cross_reference: PSY:36090
database_cross_reference: RCD:XM0l9
database_cross_reference: RXNORM:7806
database_cross_reference: SNM:F-10470
database_cross_reference: SNMI:C-10110
database_cross_reference: SNOMEDCT_US:24099007
database_cross_reference: VANDF:4019105

Oxygen Isotopes
type: Class
subclass of: Oxygen
subclass of: Isotopes
PMOID: PMO:00015364
Subclass_of: Isotopes
Subclass_of: Oxygen
Synonym: Isotopes, Oxygen
Synonym: Oxygen Isotopes [Chemical/Ingredient]
Synonym: Oxygen isotope
Synonym: Oxygen isotope (substance)
Synonym: Oxygen--Isotopes
Tree Number: T6.1.8.11.1
Tree Number: T6.1.9.14
database_cross_reference: LCH_NW:sh85096331
database_cross_reference: MSH:D010103
database_cross_reference: NDFRT:N0000166113
database_cross_reference: SNOMEDCT_US:722230006

Oxygen Radioisotopes
type: Class
subclass of: Oxygen Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015365
Subclass_of: Oxygen Isotopes
Subclass_of: Radioisotopes
Synonym: Oxygen Radioisotopes [Chemical/Ingredient]
Synonym: Oxygen radioisotope
Synonym: Oxygen radioisotope (substance)
Synonym: Radioisotopes, Oxygen
Tree Number: T6.1.9.14.1
Tree Number: T6.1.9.17.23
database_cross_reference: MSH:D010104
database_cross_reference: NDFRT:N0000166114
database_cross_reference: SNM:E-5018
database_cross_reference: SNMI:C-10111
database_cross_reference: SNOMEDCT_US:6038004

Selenium
type: Class
subclass of: Chalcogens
subclass of: Minerals
PMOID: PMO:00015366
Subclass_of: Chalcogens
Subclass_of: Minerals
Synonym: A.R.T.H. Away Formula
Synonym: B-Traxim Se
Synonym: Cell-wise
Synonym: Cell-wise Natural Source
Synonym: Complete Multivitamins and Minerals Tablets Timed Release
Synonym: Enviroflex - Tab
Synonym: Formula 14 Dietary Supplement
Synonym: Formula CF
Synonym: Formula Im-vitamins and Minerals Tab
Synonym: Formula Inf
Tree Number: T6.1.11.5
Tree Number: T6.1.6.11.3
database_cross_reference: AOD:0000019484
database_cross_reference: CHV:0000011166
database_cross_reference: CSP:1852-9448
database_cross_reference: DRUGBANK:DB11127
database_cross_reference: DRUGBANK:DB11135
database_cross_reference: LCH:U004254
database_cross_reference: LCH_NW:sh85119688
database_cross_reference: LNC:LP14283-3
database_cross_reference: LNC:MTHU007657
database_cross_reference: MEDCIN:250039
database_cross_reference: MEDLINEPLUS:4298
database_cross_reference: MMSL:10641
database_cross_reference: MMSL:5450
database_cross_reference: MMSL:d00484
database_cross_reference: MSH:D012643
database_cross_reference: MTH:U002234
database_cross_reference: MTHSPL:H6241UJ22B
database_cross_reference: NCI:C825
database_cross_reference: NCI_DCP:00930
database_cross_reference: NCI_FDA:H6241UJ22B
database_cross_reference: NCI_NCI-GLOSS:CDR0000045113
database_cross_reference: NDDF:000864
database_cross_reference: NDFRT:N0000006104
database_cross_reference: NDFRT:N0000148196
database_cross_reference: PDQ:CDR0000038725
database_cross_reference: RCD:X7987
database_cross_reference: RCD:x01Fn
database_cross_reference: RXNORM:9641
database_cross_reference: SNMI:C-11600
database_cross_reference: SNOMEDCT_US:22038003
database_cross_reference: SNOMEDCT_US:350057002
database_cross_reference: USPMG:MTHU001145
database_cross_reference: VANDF:4020392

Sulfur
type: Class
subclass of: Chalcogens
PMOID: PMO:00015367
Subclass_of: Chalcogens
Synonym: 5s Blemish Treatment
Synonym: Acne Aid Gel
Synonym: Acne Blemish Cream(sulfur Cream)
Synonym: Acne Clearning Treatment Face
Synonym: Acne LotionSulfur Sulfur
Synonym: Acne Treatment Sulfur Wash Rodan and Field
Synonym: Acne Treatment maximum strength CVS
Synonym: Acnefree Therapeutic Sulfur Mask
Synonym: Acnomel Skin Tone Cream
Synonym: Actinac Pwr
Tree Number: T6.1.6.11.4
database_cross_reference: AOD:0000019483
database_cross_reference: ATC:D10AB02
database_cross_reference: CHV:0000011874
database_cross_reference: CSP:4000-0342
database_cross_reference: DRUGBANK:DB09353
database_cross_reference: LCH_NW:sh85130365
database_cross_reference: MEDCIN:40705
database_cross_reference: MMSL:5415
database_cross_reference: MMSL:5534
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D013455
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:70FD1KFU70
database_cross_reference: NDDF:002558
database_cross_reference: NDDF:002997
database_cross_reference: NDFRT:N0000007000
database_cross_reference: NDFRT:N0000147169
database_cross_reference: RCD:Xa4kH
database_cross_reference: RCD:m63..
database_cross_reference: RCDAE:Xa4kH
database_cross_reference: RCDAE:m63..
database_cross_reference: RXNORM:10223
database_cross_reference: SNM:F-10610
database_cross_reference: SNMI:C-10800
database_cross_reference: SNOMEDCT_US:332304007
database_cross_reference: SNOMEDCT_US:43735007
database_cross_reference: VANDF:4018870

Sulfur Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015368
Subclass_of: Isotopes
Synonym: Isotopes, Sulfur
Synonym: Sulfur Isotopes [Chemical/Ingredient]
Synonym: Sulfur isotope
Synonym: Sulfur isotope (substance)
Synonym: Sulfur--Isotopes
Synonym: Sulphur isotope
Tree Number: T6.1.9.20
database_cross_reference: LCH_NW:sh85130366
database_cross_reference: MSH:D013460
database_cross_reference: NDFRT:N0000166133
database_cross_reference: SNMI:C-10801
database_cross_reference: SNOMEDCT_US:7985000

Sulfur Radioisotopes
type: Class
subclass of: Sulfur Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015369
Subclass_of: Radioisotopes
Subclass_of: Sulfur Isotopes
Synonym: Radioisotopes, Sulfur
Synonym: Sulfur Radioisotopes [Chemical/Ingredient]
Synonym: Sulfur radioisotope
Synonym: Sulfur radioisotope (substance)
Synonym: Sulfur radioisotope, NOS
Synonym: Sulphur radioisotope
Tree Number: T6.1.9.17.32
Tree Number: T6.1.9.20.1
database_cross_reference: MSH:D013462
database_cross_reference: NDFRT:N0000166134
database_cross_reference: SNM:E-5081
database_cross_reference: SNMI:C-108A0
database_cross_reference: SNOMEDCT_US:88287006

Tellurium
type: Class
subclass of: Chalcogens
subclass of: Metalloids
PMOID: PMO:00015370
Subclass_of: Chalcogens
Subclass_of: Metalloids
Synonym: TELLURIUM
Synonym: Te
Synonym: Te element
Synonym: Tellurium (substance)
Synonym: Tellurium Metallicum
Synonym: Tellurium [Chemical/Ingredient]
Synonym: Tellurium metallicum / tellurium
Synonym: Tellurium, NOS
Synonym: te
Synonym: tellurium
Tree Number: T6.1.6.11.5
Tree Number: T6.1.6.15.7
database_cross_reference: ALT:HATAL
database_cross_reference: AOD:0000019485
database_cross_reference: CHV:0000012080
database_cross_reference: CSP:1852-9515
database_cross_reference: LCH:U004601
database_cross_reference: LCH_NW:sh85133642
database_cross_reference: LNC:LP16836-6
database_cross_reference: LNC:MTHU003500
database_cross_reference: MSH:D013691
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:NQA0O090ZJ
database_cross_reference: NCI:C95192
database_cross_reference: NCI_FDA:NQA0O090ZJ
database_cross_reference: NDFRT:N0000166176
database_cross_reference: RXNORM:1311384
database_cross_reference: SNMI:C-11700
database_cross_reference: SNOMEDCT_US:41577000

Metals, Heavy
type: Class
subclass of: Elements
subclass of: Metals
PMOID: PMO:00015371
Subclass_of: Elements
Subclass_of: Metals
Synonym: Heavy Metals
Synonym: Heavy metal
Synonym: Heavy metal (substance)
Synonym: Heavy metal, NOS
Synonym: Heavy metals
Synonym: Metals, Heavy [Chemical/Ingredient]
Synonym: heavy metal
Synonym: heavy metals
Tree Number: T6.1.10.6
Tree Number: T6.1.6.12
database_cross_reference: CHV:0000031162
database_cross_reference: CSP:1852-7783
database_cross_reference: LCH_NW:sh85059851
database_cross_reference: LNC:LP14257-7
database_cross_reference: LNC:MTHU011486
database_cross_reference: MSH:D019216
database_cross_reference: NDFRT:N0000008098
database_cross_reference: RCD:X79AM
database_cross_reference: SNM:E-5290
database_cross_reference: SNMI:C-11820
database_cross_reference: SNOMEDCT_US:22907001

Antimony
type: Class
subclass of: Metals, Heavy
subclass of: Metalloids
PMOID: PMO:00015372
Subclass_of: Metalloids
Subclass_of: Metals, Heavy
Synonym: ANTIMONY
Synonym: Antimony (product)
Synonym: Antimony (substance)
Synonym: Antimony Metallicum
Synonym: Antimony [Chemical/Ingredient]
Synonym: Antimony, NOS
Synonym: Sb
Synonym: Sb - Antimony
Synonym: Sb element
Synonym: antimony
Tree Number: T6.1.10.6.3
Tree Number: T6.1.6.12.3
Tree Number: T6.1.6.15.1
database_cross_reference: AOD:0000019480
database_cross_reference: CHV:0000001309
database_cross_reference: CSP:1852-9349
database_cross_reference: DRUGBANK:DB13110
database_cross_reference: LCH:U000299
database_cross_reference: LCH_NW:sh85005702
database_cross_reference: LNC:LP16801-0
database_cross_reference: LNC:MTHU002647
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D000965
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:9IT35J3UV3
database_cross_reference: NCI:C95187
database_cross_reference: NCI_FDA:9IT35J3UV3
database_cross_reference: NDDF:006221
database_cross_reference: NDFRT:N0000166272
database_cross_reference: RCD:X808Z
database_cross_reference: RXNORM:1311407
database_cross_reference: SNMI:C-12100
database_cross_reference: SNOMEDCT_US:421045002
database_cross_reference: SNOMEDCT_US:42449005

Cadmium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015373
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: CADMIUM
Synonym: Cadmium (substance)
Synonym: Cadmium Metal
Synonym: Cadmium [Chemical/Ingredient]
Synonym: Cadmium, NOS
Synonym: Cd
Synonym: Cd - Cadmium
Synonym: Cd element
Synonym: cadmium
Synonym: cadmium (Cd)
Tree Number: T6.1.10.6.7
Tree Number: T6.1.6.12.7
Tree Number: T6.1.6.14.1
database_cross_reference: AOD:0000019465
database_cross_reference: CHV:0000002279
database_cross_reference: CSP:1852-7850
database_cross_reference: LCH:U000735
database_cross_reference: LCH_NW:sh85018635
database_cross_reference: LNC:LP16810-1
database_cross_reference: LNC:MTHU003442
database_cross_reference: MSH:D002104
database_cross_reference: MTH:U001771
database_cross_reference: MTHSPL:00BH33GNGH
database_cross_reference: NCI:C44348
database_cross_reference: NCI_FDA:00BH33GNGH
database_cross_reference: NCI_NCI-GLOSS:CDR0000344348
database_cross_reference: NDFRT:N0000166266
database_cross_reference: RCD:X7952
database_cross_reference: RXNORM:1362694
database_cross_reference: SNM:E-5152
database_cross_reference: SNMI:C-12600
database_cross_reference: SNOMEDCT_US:66586000

Chromium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015374
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Accelerator
Synonym: Actichrom
Synonym: Advanced 2000 Capsules
Synonym: Bio-chrome
Synonym: Biosculpt
Synonym: CHROMIUM
Synonym: Calcium Complex High Grade
Synonym: Calcium With Mg Zn Mn Cu CR Si and Vit. C & D
Synonym: Carbaway
Synonym: Chela-chromium 200
Tree Number: T6.1.10.6.10
Tree Number: T6.1.6.12.10
Tree Number: T6.1.6.14.2
database_cross_reference: AOD:0000019504
database_cross_reference: CHV:0000002935
database_cross_reference: CSP:1852-7917
database_cross_reference: DRUGBANK:DB09129
database_cross_reference: DRUGBANK:DB11136
database_cross_reference: LCH:U001009
database_cross_reference: LCH_NW:sh85025350
database_cross_reference: LNC:LP16812-7
database_cross_reference: LNC:MTHU005181
database_cross_reference: MDR:10008797
database_cross_reference: MEDCIN:250035
database_cross_reference: MMSL:4440
database_cross_reference: MMSL:8627
database_cross_reference: MSH:D002857
database_cross_reference: MTH:U001814
database_cross_reference: MTHSPL:0R0008Q3JB
database_cross_reference: NCI:C370
database_cross_reference: NDDF:000861
database_cross_reference: NDFRT:N0000006135
database_cross_reference: NDFRT:N0000146088
database_cross_reference: RCD:X80RB
database_cross_reference: RXNORM:2496
database_cross_reference: SNM:F-10260
database_cross_reference: SNMI:C-12900
database_cross_reference: SNOMEDCT_US:111070004
database_cross_reference: VANDF:4017719

Chromium Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015375
Subclass_of: Isotopes
Synonym: Chromium Isotopes [Chemical/Ingredient]
Synonym: Chromium isotope
Synonym: Chromium isotope (substance)
Synonym: Chromium--Isotopes
Synonym: Isotopes, Chromium
Tree Number: T6.1.9.5
database_cross_reference: LCH_NW:sh85025351
database_cross_reference: MSH:D002859
database_cross_reference: NDFRT:N0000166141
database_cross_reference: SNMI:C-12901
database_cross_reference: SNOMEDCT_US:67266008

Chromium Radioisotopes
type: Class
subclass of: Chromium Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015376
Subclass_of: Chromium Isotopes
Subclass_of: Radioisotopes
Synonym: Chromium Radioisotopes [Chemical/Ingredient]
Synonym: Chromium radioisotope
Synonym: Chromium radioisotope (substance)
Synonym: Chromium radioisotope, NOS
Synonym: Radioisotopes, Chromium
Tree Number: T6.1.9.17.8
Tree Number: T6.1.9.5.1
database_cross_reference: MSH:D002860
database_cross_reference: NDFRT:N0000166142
database_cross_reference: SNM:E-5164
database_cross_reference: SNMI:C-129A0
database_cross_reference: SNOMEDCT_US:111071000

Cobalt
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015377
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: COBALT
Synonym: Co
Synonym: Co - Cobalt
Synonym: Co element
Synonym: Cobalt (substance)
Synonym: Cobalt [Chemical/Ingredient]
Synonym: Cobalt, NOS
Synonym: Cobaltum metallicum / cobalt
Synonym: cobalt
Synonym: cobalt (Co)
Tree Number: T6.1.10.6.11
Tree Number: T6.1.6.12.11
Tree Number: T6.1.6.14.3
database_cross_reference: ALT:HACEO
database_cross_reference: AOD:0000019506
database_cross_reference: AOD:0000028720
database_cross_reference: CHV:0000003094
database_cross_reference: CSP:1852-7984
database_cross_reference: LCH:U001066
database_cross_reference: LCH_NW:sh85027513
database_cross_reference: LNC:LP14368-2
database_cross_reference: LNC:MTHU005182
database_cross_reference: MSH:D003035
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:3G0H8C9362
database_cross_reference: NCI:C382
database_cross_reference: NCI_FDA:3G0H8C9362
database_cross_reference: NDDF:004707
database_cross_reference: NDFRT:N0000006610
database_cross_reference: NDFRT:N0000022936
database_cross_reference: PSY:09920
database_cross_reference: RCD:X79A6
database_cross_reference: RXNORM:1310300
database_cross_reference: SNM:E-5228
database_cross_reference: SNM:F-10250
database_cross_reference: SNMI:C-14400
database_cross_reference: SNOMEDCT_US:54808007
database_cross_reference: VANDF:4020826

Cobalt Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015378
Subclass_of: Isotopes
Synonym: Cobalt Isotopes [Chemical/Ingredient]
Synonym: Cobalt isotope
Synonym: Cobalt isotope (substance)
Synonym: Cobalt--Isotopes
Synonym: Isotopes, Cobalt
Tree Number: T6.1.9.6
database_cross_reference: LCH_NW:sh85027514
database_cross_reference: MSH:D003036
database_cross_reference: NDFRT:N0000166123
database_cross_reference: SNMI:C-14401
database_cross_reference: SNOMEDCT_US:1603001

Cobalt Radioisotopes
type: Class
subclass of: Cobalt Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015379
Subclass_of: Cobalt Isotopes
Subclass_of: Radioisotopes
Synonym: Cobalt Radioisotopes [Chemical/Ingredient]
Synonym: Cobalt radioisotope
Synonym: Cobalt radioisotope (substance)
Synonym: Cobalt radioisotope, NOS
Synonym: Radioisotopes, Cobalt
Tree Number: T6.1.9.17.9
Tree Number: T6.1.9.6.1
database_cross_reference: MSH:D003037
database_cross_reference: NDFRT:N0000166124
database_cross_reference: SNM:E-5229
database_cross_reference: SNMI:C-144A0
database_cross_reference: SNOMEDCT_US:78870008

Copper
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015380
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: A.R.T.H. Away Formula
Synonym: Actyform
Synonym: B & J Formula Dietary Supplement
Synonym: C.A.G. Tab
Synonym: COPPER
Synonym: Cal Mag Plus - Tab
Synonym: Calcium Plus
Synonym: Calcium With Mg Zn Mn Cu CR Si and Vit. C & D
Synonym: Calplus
Synonym: Carti-aide Tab
Tree Number: T6.1.10.6.12
Tree Number: T6.1.6.12.12
Tree Number: T6.1.6.14.4
database_cross_reference: AOD:0000005761
database_cross_reference: AOD:0000028721
database_cross_reference: CHV:0000003343
database_cross_reference: CHV:0000055213
database_cross_reference: CSP:1852-8118
database_cross_reference: DRUGBANK:DB09130
database_cross_reference: DRUGBANK:DB09131
database_cross_reference: LCH:U001157
database_cross_reference: LCH_NW:sh85032278
database_cross_reference: LNC:LP16814-3
database_cross_reference: LNC:MTHU003471
database_cross_reference: MEDCIN:250030
database_cross_reference: MEDLINEPLUS:4298
database_cross_reference: MMSL:127948
database_cross_reference: MMSL:4501
database_cross_reference: MMSL:NOCODE
database_cross_reference: MMSL:d07505
database_cross_reference: MSH:D003300
database_cross_reference: MTH:U001827
database_cross_reference: MTHSPL:789U1901C5
database_cross_reference: NCI:C391
database_cross_reference: NCI_DCP:03574
database_cross_reference: NCI_FDA:789U1901C5
database_cross_reference: NDDF:000853
database_cross_reference: NDFRT:N0000005747
database_cross_reference: NDFRT:N0000146034
database_cross_reference: PSY:11800
database_cross_reference: RCD:X795J
database_cross_reference: RXNORM:2837
database_cross_reference: SNM:F-10270
database_cross_reference: SNMI:C-12700
database_cross_reference: SNOMEDCT_US:422528000
database_cross_reference: SNOMEDCT_US:66925006
database_cross_reference: VANDF:4017655

Gallium
type: Class
subclass of: Metals, Heavy
PMOID: PMO:00015381
Subclass_of: Metals, Heavy
Synonym: GALLIUM
Synonym: Ga
Synonym: Ga element
Synonym: Gallium (substance)
Synonym: Gallium [Chemical/Ingredient]
Synonym: Gallium, NOS
Synonym: ga
Synonym: gallium
Synonym: gallium(Ga)
Tree Number: T6.1.10.6.17
Tree Number: T6.1.6.12.17
database_cross_reference: AOD:0000019470
database_cross_reference: CHV:0000005325
database_cross_reference: CSP:1852-8185
database_cross_reference: DRUGBANK:DB06784
database_cross_reference: LCH:U001904
database_cross_reference: LCH_NW:sh85052848
database_cross_reference: LNC:LP16820-0
database_cross_reference: LNC:MTHU002891
database_cross_reference: MSH:D005708
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:CH46OC8YV4
database_cross_reference: NCI:C66798
database_cross_reference: NCI_FDA:CH46OC8YV4
database_cross_reference: NDDF:004829
database_cross_reference: NDFRT:N0000007939
database_cross_reference: RXNORM:1310124
database_cross_reference: SNMI:C-13100
database_cross_reference: SNOMEDCT_US:62543003

Gallium Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015382
Subclass_of: Isotopes
Synonym: Gallium Isotopes [Chemical/Ingredient]
Synonym: Gallium isotope
Synonym: Gallium isotope (substance)
Synonym: Gallium--Isotopes
Synonym: Isotopes, Gallium
Tree Number: T6.1.9.8
database_cross_reference: LCH_NW:sh85052850
database_cross_reference: MSH:D005709
database_cross_reference: NDFRT:N0000166143
database_cross_reference: SNMI:C-13101
database_cross_reference: SNOMEDCT_US:4231000

Gallium Radioisotopes
type: Class
subclass of: Gallium Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015383
Subclass_of: Gallium Isotopes
Subclass_of: Radioisotopes
Synonym: Gallium Radioisotopes [Chemical/Ingredient]
Synonym: Gallium radioisotope
Synonym: Gallium radioisotope (substance)
Synonym: Gallium radioisotope, NOS
Synonym: Radioisotopes, Gallium
Tree Number: T6.1.9.17.13
Tree Number: T6.1.9.8.1
database_cross_reference: MSH:D005710
database_cross_reference: NDFRT:N0000166144
database_cross_reference: SNM:E-5174
database_cross_reference: SNMI:C-131A0
database_cross_reference: SNOMEDCT_US:26095004

Germanium
type: Class
subclass of: Metals, Heavy
subclass of: Metalloids
PMOID: PMO:00015384
Subclass_of: Metalloids
Subclass_of: Metals, Heavy
Synonym: GERMANIUM
Synonym: Ge
Synonym: Ge element
Synonym: Germanium (substance)
Synonym: Germanium Metallicum
Synonym: Germanium [Chemical/Ingredient]
Synonym: Germanium, NOS
Synonym: ge
Synonym: germanium
Synonym: germanium (Ge)
Tree Number: T6.1.10.6.18
Tree Number: T6.1.6.12.18
Tree Number: T6.1.6.15.4
database_cross_reference: AOD:0000019475
database_cross_reference: CHV:0000005473
database_cross_reference: CSP:1852-8218
database_cross_reference: LCH:U001952
database_cross_reference: LCH_NW:sh85054449
database_cross_reference: LNC:LP16821-8
database_cross_reference: LNC:MTHU022374
database_cross_reference: MEDCIN:250038
database_cross_reference: MSH:D005857
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:00072J7XWS
database_cross_reference: NCI:C95170
database_cross_reference: NCI_FDA:00072J7XWS
database_cross_reference: NDFRT:N0000166255
database_cross_reference: NDFRT:N0000176163
database_cross_reference: RXNORM:4784
database_cross_reference: SNMI:C-12800
database_cross_reference: SNOMEDCT_US:79061004
database_cross_reference: VANDF:4027690

Gold
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015385
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Assay of gold
Synonym: Au
Synonym: Au - Gold
Synonym: Au element
Synonym: GOLD
Synonym: Gold (substance)
Synonym: Gold [Chemical/Ingredient]
Synonym: Gold, NOS
Synonym: Golds
Synonym: gold
Tree Number: T6.1.10.6.19
Tree Number: T6.1.6.12.19
Tree Number: T6.1.6.14.5
database_cross_reference: AOD:0000019524
database_cross_reference: CHV:0000005645
database_cross_reference: CSP:1852-8252
database_cross_reference: HCPCS:G6035
database_cross_reference: LCH:U002018
database_cross_reference: LCH:U002021
database_cross_reference: LCH_NW:sh85055692
database_cross_reference: LNC:LP16822-6
database_cross_reference: LNC:MTHU005003
database_cross_reference: MEDCIN:40222
database_cross_reference: MMSL:8796
database_cross_reference: MSH:D006046
database_cross_reference: MTH:U001966
database_cross_reference: MTHSPL:79Y1949PYO
database_cross_reference: NCI:C2392
database_cross_reference: NCI_FDA:79Y1949PYO
database_cross_reference: NDFRT:N0000005996
database_cross_reference: NDFRT:N0000022608
database_cross_reference: RCD:X795i
database_cross_reference: RXNORM:1311190
database_cross_reference: SNM:F-10290
database_cross_reference: SNMI:C-14600
database_cross_reference: SNOMEDCT_US:2309006
database_cross_reference: VANDF:4019622

Gold Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015386
Subclass_of: Isotopes
Synonym: Gold Isotopes [Chemical/Ingredient]
Synonym: Gold isotope
Synonym: Gold isotope (substance)
Synonym: Gold--Isotopes
Synonym: Isotopes, Gold
Tree Number: T6.1.9.9
database_cross_reference: LCH_NW:sh85055695
database_cross_reference: MSH:D006049
database_cross_reference: NDFRT:N0000166135
database_cross_reference: SNMI:C-14601
database_cross_reference: SNOMEDCT_US:5670008

Gold Radioisotopes
type: Class
subclass of: Gold Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015387
Subclass_of: Gold Isotopes
Subclass_of: Radioisotopes
Synonym: Gold Radioisotopes [Chemical/Ingredient]
Synonym: Gold radioisotope
Synonym: Gold radioisotope (substance)
Synonym: Gold radioisotope, NOS
Synonym: Radioisotopes, Gold
Tree Number: T6.1.9.17.14
Tree Number: T6.1.9.9.1
database_cross_reference: MSH:D006050
database_cross_reference: NDFRT:N0000166136
database_cross_reference: SNM:E-5232
database_cross_reference: SNMI:C-146A0
database_cross_reference: SNOMEDCT_US:14330001

Gold Colloid, Radioactive
type: Class
subclass of: Gold Colloid
PMOID: PMO:00015388
Subclass_of: Gold Colloid
Synonym: Colloid, Radioactive Gold
Synonym: Gold Colloid, Radioactive [Chemical/Ingredient]
Synonym: Gold, Radio-Colloidal
Synonym: Radio Colloidal Gold
Synonym: Radio-Colloidal Gold
Synonym: Radioactive Gold Colloid
Tree Number: T6.1.26.3.1
database_cross_reference: MSH:D006048
database_cross_reference: NDFRT:N0000166160

Hafnium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015389
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: HAFNIUM
Synonym: Hafnium (substance)
Synonym: Hafnium [Chemical/Ingredient]
Synonym: Hafnium, NOS
Synonym: Hf
Synonym: hafnium
Tree Number: T6.1.10.6.20
Tree Number: T6.1.6.12.20
Tree Number: T6.1.6.14.6
database_cross_reference: AOD:0000019517
database_cross_reference: LCH:U002064
database_cross_reference: LCH_NW:sh85058238
database_cross_reference: MSH:D006195
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:X71938L1DO
database_cross_reference: NCI:C99317
database_cross_reference: NCI_FDA:X71938L1DO
database_cross_reference: NDFRT:N0000166251
database_cross_reference: RXNORM:1534767
database_cross_reference: SNMI:C-14700
database_cross_reference: SNOMEDCT_US:50672002

Indium
type: Class
subclass of: Metals, Heavy
PMOID: PMO:00015390
Subclass_of: Metals, Heavy
Synonym: INDIUM
Synonym: In
Synonym: In element
Synonym: Indium (substance)
Synonym: Indium [Chemical/Ingredient]
Synonym: Indium, NOS
Synonym: in
Synonym: indium
Tree Number: T6.1.10.6.21
Tree Number: T6.1.6.12.21
database_cross_reference: AOD:0000019471
database_cross_reference: CHV:0000006663
database_cross_reference: CSP:1852-8319
database_cross_reference: DRUGBANK:DB11659
database_cross_reference: LCH:U002408
database_cross_reference: LCH_NW:sh85065672
database_cross_reference: LNC:LP16824-2
database_cross_reference: LNC:MTHU022378
database_cross_reference: MSH:D007204
database_cross_reference: MTH:U002006
database_cross_reference: MTHSPL:045A6V3VFX
database_cross_reference: NCI:C66827
database_cross_reference: NCI_FDA:045A6V3VFX
database_cross_reference: NDFRT:N0000166265
database_cross_reference: RXNORM:1362699
database_cross_reference: SNMI:C-14500
database_cross_reference: SNOMEDCT_US:14401009

Iridium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015391
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: IRIDIUM
Synonym: Ir
Synonym: Ir element
Synonym: Iridium (substance)
Synonym: Iridium Metallicum
Synonym: Iridium [Chemical/Ingredient]
Synonym: Iridium, NOS
Synonym: iridium
Tree Number: T6.1.10.6.22
Tree Number: T6.1.6.12.22
Tree Number: T6.1.6.14.7
database_cross_reference: AOD:0000019522
database_cross_reference: CHV:0000006920
database_cross_reference: CSP:2544-4705
database_cross_reference: LCH:U002510
database_cross_reference: LCH_NW:sh85068067
database_cross_reference: MSH:D007495
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:44448S9773
database_cross_reference: NCI:C95183
database_cross_reference: NCI_FDA:44448S9773
database_cross_reference: NDFRT:N0000166270
database_cross_reference: RXNORM:1311131
database_cross_reference: SNMI:C-15100
database_cross_reference: SNOMEDCT_US:32926003

Iron
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015392
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Actyform
Synonym: Alsimine W Vitamins A D
Synonym: Appedrine
Synonym: Ascofer Cap 275mg
Synonym: Aurovela 24 Fe
Synonym: Aurovela Fe 1/20
Synonym: Bev 29 Tab
Synonym: BioFerr 90
Synonym: Bugs Bunny Chew Multi Vit Plus Iron
Synonym: C-Nate DHA
Tree Number: T6.1.10.6.23
Tree Number: T6.1.6.12.23
Tree Number: T6.1.6.14.8
database_cross_reference: AOD:0000001943
database_cross_reference: AOD:0000028719
database_cross_reference: CCPSS:1007469
database_cross_reference: CHV:0000006926
database_cross_reference: CHV:0000027969
database_cross_reference: CSP:1629-5100
database_cross_reference: DRUGBANK:DB01592
database_cross_reference: LCH:U002512
database_cross_reference: LCH_NW:sh85068131
database_cross_reference: LNC:LP15677-5
database_cross_reference: LNC:MTHU004837
database_cross_reference: MEDCIN:41222
database_cross_reference: MEDLINEPLUS:5542
database_cross_reference: MMSL:6958
database_cross_reference: MMSL:7441
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D007501
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:E1UOL152H7
database_cross_reference: NCI:C598
database_cross_reference: NCI_DCP:01419
database_cross_reference: NCI_FDA:E1UOL152H7
database_cross_reference: NCI_NCI-GLOSS:CDR0000446805
database_cross_reference: NDDF:000828
database_cross_reference: NDFRT:N0000006237
database_cross_reference: NDFRT:N0000146032
database_cross_reference: PDQ:CDR0000042183
database_cross_reference: PSY:26640
database_cross_reference: RCD:X795v
database_cross_reference: RCD:i1z..
database_cross_reference: RXNORM:90176
database_cross_reference: SNM:E-8473
database_cross_reference: SNM:F-10360
database_cross_reference: SNMI:C-13000
database_cross_reference: SNMI:C-A6210
database_cross_reference: SNOMEDCT_US:30729008
database_cross_reference: SNOMEDCT_US:350552003
database_cross_reference: SNOMEDCT_US:373755001
database_cross_reference: SNOMEDCT_US:3829006
database_cross_reference: VANDF:4017653

Iron Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015393
Subclass_of: Isotopes
Synonym: Iron Isotopes [Chemical/Ingredient]
Synonym: Iron isotope
Synonym: Iron isotope (substance)
Synonym: Iron--Isotopes
Synonym: Isotopes, Iron
Tree Number: T6.1.9.11
database_cross_reference: LCH_NW:sh85068140
database_cross_reference: MSH:D007503
database_cross_reference: NDFRT:N0000166107
database_cross_reference: SNMI:C-13001
database_cross_reference: SNOMEDCT_US:90567005

Iron Radioisotopes
type: Class
subclass of: Iron Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015394
Subclass_of: Iron Isotopes
Subclass_of: Radioisotopes
Synonym: Iron Radioisotopes [Chemical/Ingredient]
Synonym: Iron radioisotope
Synonym: Iron radioisotope (substance)
Synonym: Iron radioisotope, NOS
Synonym: Radioisotopes, Iron
Tree Number: T6.1.9.11.1
Tree Number: T6.1.9.17.18
database_cross_reference: MSH:D007504
database_cross_reference: NDFRT:N0000166108
database_cross_reference: SNM:E-5168
database_cross_reference: SNMI:C-130A0
database_cross_reference: SNOMEDCT_US:69770009

Lead
type: Class
subclass of: Metals, Heavy
PMOID: PMO:00015395
Subclass_of: Metals, Heavy
Synonym: ???lead
Synonym: LEAD
Synonym: Lead (Metal)
Synonym: Lead (substance)
Synonym: Lead Metal
Synonym: Lead [Chemical/Ingredient]
Synonym: Lead analyte
Synonym: Lead analyte (substance)
Synonym: Lead, NOS
Synonym: Metallic Lead
Tree Number: T6.1.10.6.25
Tree Number: T6.1.6.12.25
database_cross_reference: AOD:0000019477
database_cross_reference: AOD:0000028716
database_cross_reference: CHV:0000007256
database_cross_reference: CSP:1852-8386
database_cross_reference: LCH:U002637
database_cross_reference: LCH_NW:sh85075435
database_cross_reference: LNC:LP14259-3
database_cross_reference: LNC:MTHU001584
database_cross_reference: LNC:MTHU022407
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D007854
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U002035
database_cross_reference: MTHSPL:2P299V784P
database_cross_reference: NCI:C44396
database_cross_reference: NCI_FDA:2P299V784P
database_cross_reference: NDDF:006305
database_cross_reference: NDFRT:N0000007826
database_cross_reference: PSY:27910
database_cross_reference: RCD:X79A9
database_cross_reference: RCD:Xa4kA
database_cross_reference: RXNORM:6260
database_cross_reference: SNM:F-10370
database_cross_reference: SNMI:C-13200
database_cross_reference: SNOMEDCT_US:290129001
database_cross_reference: SNOMEDCT_US:88488004

Manganese
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015396
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: 4 Trace Elements Injection, USP
Synonym: A.R.T.H. Away Formula
Synonym: Acti-MN + B1 + C Caplet
Synonym: Adrenergy Tablets
Synonym: Advanced 2000 Capsules
Synonym: Alphaligo
Synonym: Armax
Synonym: B & J Formula Dietary Supplement
Synonym: Bio-plex Tab 0.95mg
Synonym: C.H.V. Formula
Tree Number: T6.1.10.6.26
Tree Number: T6.1.6.12.26
Tree Number: T6.1.6.14.11
database_cross_reference: AOD:0000019505
database_cross_reference: AOD:0000028718
database_cross_reference: CHV:0000007724
database_cross_reference: CSP:1852-8510
database_cross_reference: DRUGBANK:DB06757
database_cross_reference: LCH:U002807
database_cross_reference: LCH_NW:sh85080479
database_cross_reference: LNC:LP16827-5
database_cross_reference: LNC:MTHU004292
database_cross_reference: MEDCIN:199599
database_cross_reference: MMSL:7425
database_cross_reference: MSH:D008345
database_cross_reference: MTH:U002061
database_cross_reference: MTHSPL:42Z2K6ZL8P
database_cross_reference: NCI:C624
database_cross_reference: NCI_DCP:01874
database_cross_reference: NDDF:000856
database_cross_reference: NDFRT:N0000007194
database_cross_reference: NDFRT:N0000146073
database_cross_reference: RCD:X79AB
database_cross_reference: RXNORM:6623
database_cross_reference: SNM:F-10410
database_cross_reference: SNMI:C-14900
database_cross_reference: SNOMEDCT_US:421451000
database_cross_reference: SNOMEDCT_US:87869004
database_cross_reference: USPMG:MTHU001749
database_cross_reference: VANDF:4017703

Mercury
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015397
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Hg
Synonym: Hg - Mercury
Synonym: Hg element
Synonym: Hydrargyrum
Synonym: Liquid Silver
Synonym: MERCURY
Synonym: Mercury (Metal)
Synonym: Mercury (substance)
Synonym: Mercury [Chemical/Ingredient]
Synonym: Mercury, NOS
Tree Number: T6.1.10.6.28
Tree Number: T6.1.6.12.28
Tree Number: T6.1.6.14.12
database_cross_reference: AOD:0000019466
database_cross_reference: CHV:0000007978
database_cross_reference: CSP:1852-8644
database_cross_reference: LCH:U002913
database_cross_reference: LCH_NW:sh85083794
database_cross_reference: LNC:LP14344-3
database_cross_reference: LNC:MTHU002897
database_cross_reference: MEDLINEPLUS:1436
database_cross_reference: MMSL:NOCODE
database_cross_reference: MSH:D008628
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:FXS1BY2PGL
database_cross_reference: NCI:C66842
database_cross_reference: NCI_FDA:FXS1BY2PGL
database_cross_reference: NCI_NCI-GLOSS:CDR0000285976
database_cross_reference: NDDF:003130
database_cross_reference: NDFRT:N0000166254
database_cross_reference: NDFRT:N0000176083
database_cross_reference: PSY:30930
database_cross_reference: RCD:X7963
database_cross_reference: RXNORM:6769
database_cross_reference: SNM:F-10390
database_cross_reference: SNMI:C-13300
database_cross_reference: SNOMEDCT_US:45262002
database_cross_reference: VANDF:4025953

Mercury Isotopes
type: Class
subclass of: Isotopes
PMOID: PMO:00015398
Subclass_of: Isotopes
Synonym: Isotopes, Mercury
Synonym: Mercury Isotopes [Chemical/Ingredient]
Synonym: Mercury isotope
Synonym: Mercury isotope (substance)
Synonym: Mercury--Isotopes
Tree Number: T6.1.9.12
database_cross_reference: LCH_NW:sh85083797
database_cross_reference: MSH:D008629
database_cross_reference: NDFRT:N0000166119
database_cross_reference: SNMI:C-13301
database_cross_reference: SNOMEDCT_US:14195003

Mercury Radioisotopes
type: Class
subclass of: Mercury Isotopes
subclass of: Radioisotopes
PMOID: PMO:00015399
Subclass_of: Mercury Isotopes
Subclass_of: Radioisotopes
Synonym: Mercury Radioisotopes [Chemical/Ingredient]
Synonym: Mercury radioisotope
Synonym: Mercury radioisotope (substance)
Synonym: Mercury radioisotope, NOS
Synonym: Radioisotopes, Mercury
Tree Number: T6.1.9.12.1
Tree Number: T6.1.9.17.21
database_cross_reference: MSH:D008631
database_cross_reference: NDFRT:N0000166120
database_cross_reference: SNM:E-5184
database_cross_reference: SNMI:C-133A0
database_cross_reference: SNOMEDCT_US:2441001

Molybdenum
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015400
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Formula Im-vitamins and Minerals Tab
Synonym: Iron 25mg With Vit B-cmplx, Vit C, Cu & Mo
Synonym: MOLYBDENUM
Synonym: Mineralex
Synonym: Mo
Synonym: Mo - Molybdenum
Synonym: Mo element
Synonym: Molybdenum (substance)
Synonym: Molybdenum [Chemical/Ingredient]
Synonym: Molybdenum, NOS
Tree Number: T6.1.10.6.29
Tree Number: T6.1.6.12.29
Tree Number: T6.1.6.14.13
database_cross_reference: AOD:0000019511
database_cross_reference: CHV:0000008220
database_cross_reference: CSP:1852-8711
database_cross_reference: DRUGBANK:DB11137
database_cross_reference: LCH:U003010
database_cross_reference: LCH_NW:sh85086637
database_cross_reference: LNC:LP16828-3
database_cross_reference: LNC:MTHU008687
database_cross_reference: MEDCIN:250033
database_cross_reference: MMSL:5128
database_cross_reference: MSH:D008982
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:81AH48963U
database_cross_reference: NCI:C666
database_cross_reference: NCI_DCP:01901
database_cross_reference: NCI_FDA:81AH48963U
database_cross_reference: NDDF:000865
database_cross_reference: NDFRT:N0000005881
database_cross_reference: NDFRT:N0000148158
database_cross_reference: PDQ:CDR0000038724
database_cross_reference: RCD:X80Ly
database_cross_reference: RXNORM:7024
database_cross_reference: SNM:F-10420
database_cross_reference: SNMI:C-15000
database_cross_reference: SNOMEDCT_US:71128006
database_cross_reference: VANDF:4020277

Nickel
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015401
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: Metallic Nickel
Synonym: NICKEL
Synonym: Ni
Synonym: Ni - Nickel
Synonym: Ni element
Synonym: Nickel (substance)
Synonym: Nickel [Chemical/Ingredient]
Synonym: Nickel, NOS
Synonym: ni
Synonym: nickel
Tree Number: T6.1.10.6.31
Tree Number: T6.1.6.12.31
Tree Number: T6.1.6.14.14
database_cross_reference: AOD:0000019507
database_cross_reference: CHV:0000008704
database_cross_reference: CSP:1852-8778
database_cross_reference: LCH:U003229
database_cross_reference: LCH_NW:sh85091772
database_cross_reference: LNC:LP16829-1
database_cross_reference: LNC:MTHU003538
database_cross_reference: MSH:D009532
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7OV03QG267
database_cross_reference: NCI:C690
database_cross_reference: NCI_FDA:7OV03QG267
database_cross_reference: NDDF:006308
database_cross_reference: NDFRT:N0000006488
database_cross_reference: NDFRT:N0000022900
database_cross_reference: RCD:X79AE
database_cross_reference: RXNORM:1311629
database_cross_reference: SNM:F-10430
database_cross_reference: SNMI:C-13400
database_cross_reference: SNOMEDCT_US:33396006
database_cross_reference: VANDF:4020727

Niobium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015402
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: NIOBIUM
Synonym: Niobium [Chemical/Ingredient]
Synonym: niobium
Tree Number: T6.1.10.6.32
Tree Number: T6.1.6.12.32
Tree Number: T6.1.6.14.15
database_cross_reference: AOD:0000019510
database_cross_reference: CHV:0000008724
database_cross_reference: DRUGBANK:DB13031
database_cross_reference: LCH:U003235
database_cross_reference: LCH_NW:sh85091993
database_cross_reference: LNC:LP188755-5
database_cross_reference: LNC:MTHU049026
database_cross_reference: MSH:D009556
database_cross_reference: MTHSPL:05175J654G
database_cross_reference: NDFRT:N0000166256
database_cross_reference: RXNORM:1426867

Osmium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015403
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: OSMIUM
Synonym: Os
Synonym: Os - Osmium
Synonym: Os element
Synonym: Osmium (substance)
Synonym: Osmium Metallicum
Synonym: Osmium [Chemical/Ingredient]
Synonym: Osmium metallicum / osmium
Synonym: Osmium, NOS
Synonym: osmium
Tree Number: T6.1.10.6.34
Tree Number: T6.1.6.12.34
Tree Number: T6.1.6.14.16
database_cross_reference: ALT:HAOAR
database_cross_reference: AOD:0000019521
database_cross_reference: CHV:0000009059
database_cross_reference: CSP:1852-8831
database_cross_reference: LCH:U003397
database_cross_reference: LCH_NW:sh85095926
database_cross_reference: LNC:LP19176-4
database_cross_reference: LNC:MTHU006112
database_cross_reference: MSH:D009992
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:2E7M255OPY
database_cross_reference: NCI:C95182
database_cross_reference: NCI_FDA:2E7M255OPY
database_cross_reference: NDFRT:N0000166267
database_cross_reference: RCD:X796R
database_cross_reference: RXNORM:1311130
database_cross_reference: SNMI:C-15200
database_cross_reference: SNOMEDCT_US:72578004

Palladium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015404
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: PALLADIUM
Synonym: Palladium (substance)
Synonym: Palladium Metallicum
Synonym: Palladium [Chemical/Ingredient]
Synonym: Palladium metallicum / palladium
Synonym: Palladium, NOS
Synonym: Pd
Synonym: Pd - Palladium
Synonym: Pd element
Synonym: palladium
Tree Number: T6.1.10.6.35
Tree Number: T6.1.6.12.35
Tree Number: T6.1.6.14.17
database_cross_reference: ALT:HAPAB
database_cross_reference: AOD:0000019515
database_cross_reference: CHV:0000009196
database_cross_reference: CSP:1852-8845
database_cross_reference: LCH:U003446
database_cross_reference: LCH_NW:sh85097207
database_cross_reference: LNC:LP65754-1
database_cross_reference: LNC:MTHU026991
database_cross_reference: MSH:D010165
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:5TWQ1V240M
database_cross_reference: NCI:C95184
database_cross_reference: NCI_FDA:5TWQ1V240M
database_cross_reference: NDDF:016321
database_cross_reference: NDFRT:N0000166240
database_cross_reference: RCD:Xa4kD
database_cross_reference: RXNORM:1311279
database_cross_reference: SNMI:C-16000
database_cross_reference: SNOMEDCT_US:48714008

Platinum
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015405
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: PLATINUM
Synonym: Platinum (substance)
Synonym: Platinum Black
Synonym: Platinum [Chemical/Ingredient]
Synonym: Platinum, NOS
Synonym: Pt
Synonym: Pt - Platinum
Synonym: Pt element
Synonym: platinum
Synonym: platinum (Pt)
Tree Number: T6.1.10.6.36
Tree Number: T6.1.6.12.36
Tree Number: T6.1.6.14.18
database_cross_reference: AOD:0000019523
database_cross_reference: CHV:0000009840
database_cross_reference: CSP:1852-8912
database_cross_reference: DRUGBANK:DB12257
database_cross_reference: LCH:U003717
database_cross_reference: LCH_NW:sh85103305
database_cross_reference: LNC:LP14931-7
database_cross_reference: LNC:MTHU002192
database_cross_reference: MSH:D010984
database_cross_reference: MTH:NOCODE
database_cross_reference: MTH:U000086
database_cross_reference: MTHSPL:49DFR088MY
database_cross_reference: NCI:C376
database_cross_reference: NCI:C756
database_cross_reference: NCI_FDA:49DFR088MY
database_cross_reference: NCI_NCI-GLOSS:CDR0000045841
database_cross_reference: NDFRT:N0000166244
database_cross_reference: RCD:X79AG
database_cross_reference: RXNORM:1311280
database_cross_reference: SNMI:C-15300
database_cross_reference: SNOMEDCT_US:84847000

Rhenium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015406
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: RHENIUM
Synonym: Rhenium (substance)
Synonym: Rhenium [Chemical/Ingredient]
Synonym: rhenium
Tree Number: T6.1.10.6.40
Tree Number: T6.1.6.12.40
Tree Number: T6.1.6.14.19
database_cross_reference: AOD:0000019520
database_cross_reference: CHV:0000010839
database_cross_reference: LCH:U004116
database_cross_reference: LCH_NW:sh85113607
database_cross_reference: MSH:D012211
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:7YHU292INY
database_cross_reference: NDFRT:N0000166247
database_cross_reference: RXNORM:1667763
database_cross_reference: SNOMEDCT_US:396000007

Rhodium
type: Class
subclass of: Metals, Heavy
subclass of: Transition Elements
PMOID: PMO:00015407
Subclass_of: Metals, Heavy
Subclass_of: Transition Elements
Synonym: RHODIUM
Synonym: Rh
Synonym: Rh element
Synonym: Rhodium (substance)
Synonym: Rhodium Metallicum
Synonym: Rhodium [Chemical/Ingredient]
Synonym: Rhodium metallicum / rhodium
Synonym: Rhodium, NOS
Synonym: rhodium
Synonym: rhodium metallicum/rhodium
Tree Number: T6.1.10.6.41
Tree Number: T6.1.6.12.41
Tree Number: T6.1.6.14.20
database_cross_reference: ALT:HARAR
database_cross_reference: AOD:0000019514
database_cross_reference: CSP:1852-8954
database_cross_reference: LCH:U004129
database_cross_reference: LCH_NW:sh85113755
database_cross_reference: MSH:D012238
database_cross_reference: MTH:NOCODE
database_cross_reference: MTHSPL:DMK383DSAC
database_cross_reference: NCI:C95190
database_cross_reference: NCI_FDA:DMK383DSAC
database_cross_reference: NDFRT:N0000166250
database_cross_reference: RXNORM:1311402
database_cross_reference: SNMI:C-16700
database_cross_reference: SNOMEDCT_US:59801003